Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 14 Feb 2018 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). Contact: Stephan Schurer stephan dot schurer at gmail dot com Created by: Saurabh Mehta, Nooshin Nabizadeh, Amar Koleti, Dusica Vidovic, Yu Asiyah Lin, Hande McGinty, Stephan Schurer* Release date: December 28, 2015 This file contains the axoims for chebi import contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 1.1.1 Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. Really of interest to developers only BFO OWL specification label Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 Person:Alan Ruttenberg Really of interest to developers only BFO CLIF specification label editor preferred term example of usage has curation status definition definition editor note alternative term definition source curator note imported from elucidation has associated axiom(nl) has associated axiom(fol) An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context. temporal interpretation https://github.com/oborel/obo-relations/wiki/ROAndTime S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T. RO:0002174 uberon dubious_for_taxon 1 1 dubious_for_taxon this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost dubious_for_taxon logical macro assertion on an object property An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class. UBPROP:0000001 uberon external_definition 1 external_definition This annotation property may be replaced with an annotation property from an external ontology such as IAO external_definition A textual description of an axiom loss in this ontology compared to an external ontology. UBPROP:0000002 uberon axiom_lost_from_external_ontology 1 axiom_lost_from_external_ontology This annotation property may be replaced with an annotation property from an external ontology such as IAO axiom_lost_from_external_ontology Notes on the homology status of this class. UBPROP:0000003 uberon homology_notes 1 homology_notes This annotation property may be replaced with an annotation property from an external ontology such as IAO homology_notes UBPROP:0000007 uberon has_relational_adjective 1 has_relational_adjective Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. has_relational_adjective UBPROP:0000008 uberon taxon_notes 1 taxon_notes taxon_notes uberon fma_set_term 1 FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term fma_set_term has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_namespace has_related_synonym in_subset shorthand uberon foaf-depicted_by 1 foaf-depicted_by depicted_by BrendaTissueOBO develops_from derives from/develops from BrendaTissueOBO part_of part of BrendaTissueOBO related_to related to has functional parent is conjugate acid of is conjugate base of is enantiomer of is tautomer of map to pfam domain is part of has amino acid residue is mutated form of some evidence is considered for Star Score between 2.5 and 3.5 adopted from TISSUES database (tissues.jensenlab.org/). is expressed in tissue with at least some evidence from TISSUES weak evidence is considered for Star Score between zero and 2.4 adopted from TISSUES database (tissues.jensenlab.org/). is expressed in tissue with at least weak evidence from TISSUES is gene template of has associated gene from DISEASE is associated tissue of weak evidence is considered for Star Score between zero and 2.4 adopted from DISEASES database (http://diseases.jensenlab.org/) has associated disease with at least weak evidence from DISEASES some evidence is considered for Star Score between 2.5 and 3.5 adopted from DISEASES database (http://diseases.jensenlab.org/) has associated disease with at least some evidence from DISEASES strong evidence is considered for Star Score between 3.6 and 5 adopted from DISEASES database (http://diseases.jensenlab.org/) has associated disease with strong evidence from DISEASES strong evidence is considered for Star Score between 3.6 and 5 adopted from TISSUES database (tissues.jensenlab.org/). is expressed in tissue with strong evidence from TISSUES has associated tissue has gating mechanism transports molecular entity has topology binds molecular entity has quaternary organization has quality has gene template has target development level is target development level of weak evidence is considered for Star Score between zero and 2.4 adopted from TISSUES database (tissues.jensenlab.org/). is expression location of gene with at least weak evidence from TISSUES some evidence is considered for Star Score between 2.5 and 3.5 adopted from TISSUES database (tissues.jensenlab.org/). is expression location of gene with at least some evidence from TISSUES strong evidence is considered for Star Score between 3.6 and 5 adopted from TISSUES database (tissues.jensenlab.org/). is expression location of gene with strong evidence from TISSUES is transported by has associated disease from DISEASES weak evidence is considered for Star Score between zero and 2.4 adopted from DISEASES database (http://diseases.jensenlab.org/) has associated gene with at least weak evidence from DISEASE some evidence is considered for Star Score between 2.5 and 3.5 adopted from DISEASES database (http://diseases.jensenlab.org/) has associated gene with at least some evidence from DISEASE strong evidence is considered for Star Score between 3.6 and 5 adopted from DISEASES database (http://diseases.jensenlab.org/) has associated gene with strong evidence from DISEASE derives from organ has amino acid position BFO:0000019 quality Quality the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] quality BFO:0000023 role Role John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] role BTO:0000000 A structured controlled vocabulary for the source of an enzyme. It comprises terms of tissues, cell lines, cell types and cell cultures from uni- and multicellular organisms. BrendaTissueOBO BTO:0000000 tissues, cell types and enzyme sources BTO:0000003 BrendaTissueOBO BTO:0000003 intestinal cell line BTO:0000006 A benign tumor cell of bone. BrendaTissueOBO BTO:0000006 osteoblastoma cell BTO:0000007 Established from a human primary embryonal kidney transformed by adenovirus type 5. BrendaTissueOBO 293 cell A-293 cell A293 cell HEK cell HEK293 cell human embryonal kidney cell human embryonic kidney cell BTO:0000007 HEK-293 cell BTO:0000011 L1 is a continuous substrain of 3T3 Swiss albino developed through clonal isolation. Cells undergo a pre-adipose to adipose like conversion as they progress from a rapidly dividing to a confluent and contact inhibited state. A high serum content in the medium enhances fat accumulation. BrendaTissueOBO NIH3T3-L1 cell BTO:0000011 3T3-L1 cell BTO:0000017 Human epidermoid carcinoma established from the solid tumor of an 85-year-old woman; cells were reported to have large numbers of EGF binding sites; cell line was used as indicator cell line for anti-TGF binding. BrendaTissueOBO A431 cell BTO:0000017 A-431 cell BTO:0000019 Rat embryonic thoracic aorta smooth muscle cell line. The cells exhibit an increase in activity of the enzymes myokinase and creatine phosphokinase (CPK) as the culture reaches stationary phase. Muscle type CPK is synthesized after cell division has ceased. BrendaTissueOBO BTO:0000019 A7r5 cell BTO:0000021 BrendaTissueOBO BTO:0000021 head muscle BTO:0000024 The fourth compartment of the ruminant stomach that follows the omasum and has a true digestive function. BrendaTissueOBO fourth stomach BTO:0000024 abomasum BTO:0000031 BrendaTissueOBO BTO:0000031 fruit peduncle BTO:0000032 A cell of an adenocarcinoma of the colon is a malignant neoplastic epithelial lesion, arising from the colonic mucosa. BrendaTissueOBO adenocarcinoma cell, colon colon adenocarcinoma cell BTO:0000032 colonic adenocarcinoma cell BTO:0000035 Adenocarcinoma cell related to the colon and/or rectum. BrendaTissueOBO adenocarcinoma cell, colorectal BTO:0000035 colorectal adenocarcinoma cell BTO:0000036 A cell of any of a group of common stomach cancers, usually located in the antrum; it may present as a bulky mass with central ulceration invading the wall, a mass that narrows the antral lumen, a polypoid lesion, or a tumor that spreads superficially over the mucosal surface. It is common in Japan, Chile, Iceland, and Finland but the incidence is decreasing in North America and elsewhere. There may be links to certain dietary substances such as nitrosamines and benzpyrene. BrendaTissueOBO adenocarcinoma cell of the stomach gastric carcinoma cell BTO:0000036 gastric adenocarcinoma cell BTO:0000037 Carcinoma cell of the renal parenchyma usually occurring in middle age or later and composed of tubular cells in varying arrangements; symptoms depend on extent of invasion. BrendaTissueOBO CCRCC cell Grawitz`s tumor cell adenocarcinoma cell of kidney clear cell carcinoma cell clear cell renal cell carcinoma cell hypernephroid carcinoma cell hypernephroma cell kidney adenocarcinoma cell renal adenocarcinoma cell BTO:0000037 renal cell carcinoma cell BTO:0000041 The part of the vertebrate brain that is continuous posteriorly with the spinal cord and that contains the centers controlling involuntary vital functions. BrendaTissueOBO metepencephalon BTO:0000041 medulla oblongata BTO:0000042 Any of a kingdom (Animalia) of living things including many-celled organisms and often many of the single-celled ones (as protozoans) that typically differ from plants in having cells without cellulose walls, in lacking chlorophyll and the capacity for photosynthesis, in requiring more complex food materials (as proteins), in being organized to a greater degree of complexity, and in having the capacity for spontaneous movement and rapid motor responses to stimulation. BrendaTissueOBO Tier animalia metazoa BTO:0000042 animal BTO:0000045 The outer portion of the adrenal glands that produces several steroid hormones, including cortisol and aldosterone. BrendaTissueOBO cortex glandulae suprarenalis cortex of adrenal gland cortex of suprarenal gland suprarenal cortex BTO:0000045 adrenal cortex BTO:0000046 Mouse adrenal cortex tumor. Mouse, LAF1 male; Tissue: adrenal cortex; Tumor: adrenal tumor. BrendaTissueOBO Y1 cell BTO:0000046 Y-1 cell BTO:0000047 Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine. BrendaTissueOBO adrenal adrenal capsule atrabiliary capsule epinephros glandula suprarenalis suprarenal capsule suprarenal gland BTO:0000047 adrenal gland BTO:0000050 The middle of the three layers of the adrenal cortex that consists of radially arranged columnar epithelial cells. BrendaTissueOBO BTO:0000050 zona fasciculata BTO:0000054 The posterior oviduct opens into the large white albumen gland which adds a layer of albumen to the zygote before it reaches the egg capsule gland. BrendaTissueOBO BTO:0000054 albumen gland BTO:0000062 Any of the bodies representing the morphologic (leishmanial) stage in the life cycle of all trypanosomatid protozoa resembling the typical adult form of members of the genus Leishmania, in which the oval or round cell has a nucleus, kinetoplast, and basal body but lacks a free-flowing flagellum, the flagellum being either very short or entirely absent. BrendaTissueOBO Leishman-Donovan body aflagellate form leishmanial form micromastigote spheromastigote BTO:0000062 amastigote BTO:0000065 A thin, tough, membranous sac that encloses the embryo or fetus of a mammal, bird, or reptile. It is filled with a serous fluid in which the embryo is suspended. BrendaTissueOBO BTO:0000065 amnion BTO:0000067 BrendaTissueOBO renal cell line BTO:0000067 kidney cell line BTO:0000068 Fluid within the amniotic cavity produced by the amnion during the early embryonic period, and later by the lungs and kidneys; at first crystal clear, it later becomes cloudy. It protects the embryo and fetus from injury. The amount at term normally varies from 500 to 1500 mL. BrendaTissueOBO acqua amnii liquor amnii BTO:0000068 amniotic fluid BTO:0000069 Human amnion cell line with HeLa markers. BrendaTissueOBO BTO:0000069 WISH cell BTO:0000075 Excretory gland situated in the basal article of the antennal peduncle. BrendaTissueOBO BTO:0000075 antennal gland BTO:0000077 BrendaTissueOBO BTO:0000077 posterior midgut BTO:0000078 The small, non-neural, interstitial cells of mesodermal origin that form part of the supporting structure of the central nervous system. They are of various forms and may have slender branched processes. They are migratory and act as phagocytes to waste products of nerve tissue. BrendaTissueOBO Hortega cell microglial cell microgliocyte BTO:0000078 microglia BTO:0000079 The male reproductive organ enclosing and containing the pollen grains. BrendaTissueOBO BTO:0000079 anther BTO:0000080 BrendaTissueOBO BTO:0000080 male reproductive gland BTO:0000081 In women, the organs that are directly involved in producing eggs and in conceiving and carrying babies. In men, the organs directly involved in creating, storing, and delivering sperm to fertilize an egg. BrendaTissueOBO Geschlechtsorgan animal reproductive system genital system genitalia organa genitalia reproductive tissue BTO:0000081 reproductive system BTO:0000084 A narrow blind tube usually about three or four inches (7.6 to 10.2 centimeters) long that extends from the cecum in the lower right-hand part of the abdomen, has much lymphoid wall tissue, normally communicates with the cavity of the cecum, and represents an atrophied terminal part of the cecum. BrendaTissueOBO appendix BTO:0000084 vermiform appendix BTO:0000089 1: The fluid that circulates in the heart, arteries, capillaries, and veins of a vertebrate animal carrying nourishment and oxygen to and bringing away waste products from all parts of the body. 2: A comparable fluid of an invertebrate. BrendaTissueOBO whole blood BTO:0000089 blood BTO:0000090 Any of a class (Ascidiacea) of solitary or colonial sessile tunicates that have an oral and an atrial siphon. BrendaTissueOBO sea squirt BTO:0000090 ascidian BTO:0000091 Accumulation of serous fluid in the spaces between tissues and organs in the cavity of the abdomen. BrendaTissueOBO ascites fluid ascitic fluid BTO:0000091 ascites BTO:0000092 Any of a genus (Trypanosoma) of parasitic flagellate protozoans that infest the blood of various vertebrates including humans, are usually transmitted by the bite of an insect, and include some that cause serious disease (as sleeping sickness). BrendaTissueOBO trypanid form trypanosomatid form BTO:0000092 trypanosomoid form BTO:0000095 Mouse embryonal carcinoma, initiated from a testicular teratocarcinoma of a strain 129 mouse. BrendaTissueOBO F9 EC cell F9 cell F9 embryonal carcinoma cell F9-EC cell BTO:0000095 F-9 cell BTO:0000096 BrendaTissueOBO BTO:0000096 urinary bladder cell line BTO:0000099 A star-shaped cell, especially a neuroglial cell of nervous tissue. BrendaTissueOBO BTO:0000099 astrocyte BTO:0000100 A tumor cell composed of astrocytes; it is the most common type of primary brain tumor and is also found throughout the central nervous system. One classification groups astrocytomas according to their histologic appearance and distinguishes pilocytic, protoplasmic, gemistocytic, and fibrillary types. Another classification groups them in order of increasing malignancy as Grade I, Grade II, Grade III, and Grade IV types. BrendaTissueOBO astrocytic glioma cell astroglial neoplasm cell astroglial tumor cell astroglioma cell BTO:0000100 astrocytoma cell BTO:0000101 BrendaTissueOBO BTO:0000101 astrocytoma cell line BTO:0000102 A semisolid gelatinous mass of coagulated blood that consists of red blood cells, white blood cells, and platelets entrapped in a fibrin network. BrendaTissueOBO thrombus BTO:0000102 blood clot BTO:0000104 Lymphoma means any neoplastic disorder of the lymphoid tissue. BrendaTissueOBO lymphadenoma cell line BTO:0000104 lymphoma cell line BTO:0000106 BrendaTissueOBO head ganglion BTO:0000106 cranial ganglion BTO:0000108 Pseudostratified epithelium lining the olfactory region of the nasal cavity, and containing the receptors for the sense of smell. BrendaTissueOBO nasal cavity olfactory epithelium nasal epithelium olfactory mucosa olfactory sensory epithelium BTO:0000108 olfactory epithelium BTO:0000109 An irregularly shaped bacterium (as a rhizobium) found especially in root nodules of legumes. BrendaTissueOBO BTO:0000109 bacteroid BTO:0000110 BrendaTissueOBO BTO:0000110 amniotic cell line BTO:0000113 Any of three sympathetic ganglia on each side of the neck. BrendaTissueOBO BTO:0000113 cervical ganglion BTO:0000120 Syrian hamster kidney BHK-21 is a subclone (clone 13) of the parental line established from the kidneys of five unsexed, one-day-old hamsters in 1961; cells can be used for virus replication studies. BrendaTissueOBO BHK 21 cell BHK-21/C13 cell baby hamster kidney cell BTO:0000120 BHK-21 cell BTO:0000121 A fluid secreted by the liver and poured into the small intestine via the bile ducts. Important constituents are conjugated bile salts, cholesterol, phospholipid, bilirubin diglucuronide, and electrolytes. Bile is alkaline due to its bicarbonate content, is golden brown to greenish yellow in color, and has a bitter taste. Bile secreted by the liver is concentrated in the gallbladder. BrendaTissueOBO fel gall BTO:0000121 bile BTO:0000122 Any of the ducts that convey bile in and from the liver. BrendaTissueOBO biliary duct gall duct BTO:0000122 bile duct BTO:0000123 A membranous sac in animals that serves as the receptacle of a liquid or contains gas. BrendaTissueOBO BTO:0000123 bladder BTO:0000124 Haploid cells produced by meiosis in the anthers of angiosperms; four microspores are produced from a single microsporocyte. BrendaTissueOBO BTO:0000124 microspore BTO:0000128 The usually spherical structure produced by cleavage of a zygote, consisting of a single layer of cells (blastoderm) surrounding a fluid-filled cavity (blastocoele). BrendaTissueOBO blastosphere BTO:0000128 blastula BTO:0000129 Mammalian granulocyte with large heterochromatic basophilic granules that contain histamine bound to a protein and heparin-like mucopolysaccharide matrix. They are not phagocytic. Very similar to mast cells though it is not clear whether they have common lineage. BrendaTissueOBO basophil granulocyte basophilic leucocyte basophilic leukocyte BTO:0000129 basophil BTO:0000130 A granulocyte that is the chief phagocytic white blood cell of the blood. BrendaTissueOBO neutrophil granulocyte neutrophilic leucocyte neutrophilic leukocyte BTO:0000130 neutrophil BTO:0000131 The fluid portion of the blood in which the particulate components are suspended. BrendaTissueOBO plasma BTO:0000131 blood plasma BTO:0000132 A minute, nonnucleated, disklike cytoplasmic body found in the blood plasma of mammals that is derived from a megakaryocyte and functions to promote blood clotting. BrendaTissueOBO platelet thrombocyte BTO:0000132 blood platelet BTO:0000134 When living in the mammalian bloodstream T. brucei has neither a functional Krebs cycle nor oxidative phosphorylation nor does it store any carbohydrates. In the bloodstream form. Its metabolism is restricted to the glycolytic pathway alone. BrendaTissueOBO BTO:0000134 bloodstream form BTO:0000135 The great arterial trunk that carries blood from the heart to be distributed by branch arteries through the body. BrendaTissueOBO trunk of aortic tree trunk of systemic arterial tree BTO:0000135 aorta BTO:0000139 The portion of an animal body that consists of ectoderm and mesoderm, forms the external body surface, and encloses the body cavity. BrendaTissueOBO Koerperwand BTO:0000139 body wall BTO:0000140 The hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral, component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate (85 per cent) and calcium carbonate (10 per cent), which imparts the quality of rigidity to bone. BrendaTissueOBO osseous tissue BTO:0000140 bone BTO:0000141 The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells. BrendaTissueOBO medulla of bone medulla ossea medulla ossium BTO:0000141 bone marrow BTO:0000142 1: The portion of the vertebrate central nervous system that constitutes the organ of thought and neural coordination, includes all the higher nervous centers receiving stimuli from the sense organs and interpreting and correlating them to formulate the motor impulses, is made up of neurons and supporting and nutritive structures, is enclosed within the skull, and is continuous with the spinal cord through the foramen magnum. Also named encephalon. 2: A nervous center in invertebrates comparable in position and function to the vertebrate brain. BrendaTissueOBO encephalon BTO:0000142 brain BTO:0000143 The substantia nigra is located in the mesencephalon (mid brain) region of the brain. It is part of the basal ganglia. BrendaTissueOBO BTO:0000143 substantia nigra BTO:0000146 The part of the brain composed of the mesencephalon, pons, and medulla oblongata and connecting the spinal cord with the forebrain and cerebrum. BrendaTissueOBO brainstem truncus encephalicus BTO:0000146 brain stem BTO:0000149 The fore or ventral part of the body between the neck and the abdomen. BrendaTissueOBO BTO:0000149 breast BTO:0000150 Breast cancer is an uncontrolled growth of malignant breast tissue. Most breast cancers begin in the milk ducts: these are called intraductal cancers. A few, like lobular cancer, start in the milk sacs or lobes. BrendaTissueOBO breast adenocarcinoma cell breast carcinoma cell breast epithelial cancer cell breast tumor cell mammary adenocarcinoma cell mammary cancer cell mammary carcinoma cell mammary tumor cell BTO:0000150 breast cancer cell BTO:0000151 A muscle that, upon contraction, tends to straighten a limb. The antagonist of a flexor muscle. BrendaTissueOBO BTO:0000151 extensor BTO:0000155 A technique by which cells and fluid from bronchioles and lung alveoli are removed for diagnosis of disease or evaluation of treatment. A bronchoscope is wedged into a bronchus and sterile saline is pumped in and then removed along with the fluid and cells to be analyzed. BrendaTissueOBO BAL cell bronchioalveolar lavage bronchioalveolar lavage fluid bronchoalveolar lavage fluid BTO:0000155 bronchoalveolar lavage BTO:0000156 A mammalian heat-producing tissue occurring especially in human newborns and in hibernators. BrendaTissueOBO brown fat BTO:0000156 brown adipose tissue BTO:0000159 A resting stage of a plant (as the lily, onion, hyacinth, or tulip) that is usually formed underground and consists of a short stem base bearing one or more buds enclosed in overlapping membranous or fleshy leaves. BrendaTissueOBO BTO:0000159 bulb BTO:0000160 Sheath of parenchyma or sclerenchyma cells surrounding the vascular bundles in leaves. BrendaTissueOBO BTO:0000160 bundle sheath BTO:0000161 BrendaTissueOBO BTO:0000161 lung fibroblast cell line BTO:0000166 The first part of the large intestine, forming a dilated pouch into which open the ileum, colon, and appendix vermiformis. BrendaTissueOBO blind intestine blindgut caecum intestinum caecum intestinum crassum caecum intestinum crassum cecum BTO:0000166 cecum BTO:0000167 BrendaTissueOBO BTO:0000167 adenocarcinoma cell line BTO:0000169 The usually green outer whorl of a flower consisting of sepals. BrendaTissueOBO BTO:0000169 calyx BTO:0000170 A thin formative layer between the xylem and phloem of most vascular plants that gives rise to new cells and is responsible for secondary growth; A lateral meristem in vascular plants, including the vascular cambium and cork cambium, that forms parallel rows of cells resulting in secondary tissues. BrendaTissueOBO BTO:0000170 cambium BTO:0000171 The H226Br cell line is a variant of the NCI-H226 cell line derived from a brain metastasis in a nu/nu mouse. Marion 2014-03-03T20:51:18Z BrendaTissueOBO H-226Br cell H226Br cell BTO:0000171 NCI-H226Br cell BTO:0000173 A simple fruit that develops from a compound ovary with two or more carpels; capsules dehisce in many ways, example: cotton. BrendaTissueOBO plant capsule BTO:0000173 fruit capsule BTO:0000174 An anatomical structure that exists only before the organism is fully formed. In mammals, for example, a structure that exists only prior to the birth of the organism. This structure may be normal or abnormal. BrendaTissueOBO embryonale Struktur BTO:0000174 embryonic structure BTO:0000176 A cell of malignant new growth made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. BrendaTissueOBO basal cell epithelioma cell epithelial cancer cell epithelial carcinoma cell malignant epithelioma cell BTO:0000176 carcinoma cell BTO:0000177 Ovarian adenocarcinoma cell line. BrendaTissueOBO BG1 cell BTO:0000177 BG-1 cell BTO:0000178 A benign epithelial tumor cell in which the cells form recognizable glandular structures or in which the cells are clearly derived from glandular epithelium. BrendaTissueOBO BTO:0000178 adenoma cell BTO:0000180 A cancer cell of the uterine cervix (the neck of the uterus). BrendaTissueOBO carcinoma cell, cervical cervical cancer cell cervix cancer cell cervix carcinoma cell uterine cervix carcinoma cell BTO:0000180 cervical carcinoma cell BTO:0000183 BrendaTissueOBO BTO:0000183 pancreatic cell line BTO:0000184 A cell ot a type of thyroid gland carcinoma that contains amyloid deposits and parafollicular cells and secretes calcitonin. It occurs in both an autosomal dominant form as a component of multiple endocrine neoplasia, types II and III, and in a nonfamilial form. BrendaTissueOBO MTC cell medullary carcinoma cell of thyroid gland thyroid carcinoma cell, medullary BTO:0000184 medullary thyroid carcinoma cell BTO:0000188 BrendaTissueOBO BTO:0000188 colonic cell line BTO:0000189 A cell of a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells that are intensely hematoxyphilic. Metastasis to the hilum and to mediastinal lymph nodes is common. BrendaTissueOBO SCLC cell small cell carcinoma cell small cell lung carcinoma cell BTO:0000189 small cell lung cancer cell BTO:0000191 A cell of a carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. BrendaTissueOBO carcinoma molle cell carcinoma spongiosum cell cerebriform cancer cell cerebriform carcinoma cell encephaloid cancer cell soft cancer cell BTO:0000191 medullary carcinoma cell BTO:0000192 A cell of a disease in which cancer (malignant) cells are found in the tissues of the nasopharynx. BrendaTissueOBO carcinoma cell, nasopharynx nasopharyngeal cancer cell nasopharynx cancer cell nasopharynx carcinoma cell BTO:0000192 nasopharyngeal carcinoma cell BTO:0000193 Cancer cell of the rectum. BrendaTissueOBO carcinoma cell, rectal rectal carcinoma cell BTO:0000193 rectal cancer cell BTO:0000194 Ovarian carcinoma cell which resembles typical carcinoma of the endometrium and may be seen with a synchronous endometrial carcinoma. When they appear together, both tend to be of low stage. BrendaTissueOBO BTO:0000194 endometrioid carcinoma cell BTO:0000196 Cancer cell of the thyroid gland. BrendaTissueOBO carcinoma cell, thyroid thyroid carcinoma cell BTO:0000196 thyroid cancer cell BTO:0000199 The principal muscle tissue of the vertebrate heart made up of striated fibers that appear to be separated from each other under the electron microscope but that function in long-term rhythmic contraction as if in protoplasmic continuity. BrendaTissueOBO heart muscle muscle of heart BTO:0000199 cardiac muscle BTO:0000201 BrendaTissueOBO BTO:0000201 pheochromocytoma cell line BTO:0000202 A bodily structure that receives a stimulus (as heat or sound waves) and is affected in such a manner as to initiate a wave of excitation in associated sensory nerve fibers which convey specific impulses to the central nervous system where they are interpreted as corresponding sensations: RECEPTOR. BrendaTissueOBO Sinnesorgan BTO:0000202 sense organ BTO:0000203 A system of organs subserving the function of respiration and in air-breathing vertebrates consisting typically of the lungs and their nervous and circulatory supply and the channels by which these are continuous with the outer air. BrendaTissueOBO Atmungssystem apparatus respiratorius respiratory tract BTO:0000203 respiratory system BTO:0000204 A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control. BrendaTissueOBO BTO:0000204 carotid body BTO:0000205 A plexus made up of intermingled nerve fibers. BrendaTissueOBO BTO:0000205 nerve plexus BTO:0000206 A specialized, fibrous connective tissue, forming most of the temporary skeleton of the embryo, providing a model in which most of the bones develop, and constituting an important part of the growth mechanism of the organism. It exists in several types, the most important of which are hyaline cartilage, elastic cartilage, and fibrocartilage. Also used as a general term to designate a mass of such tissue in a particular site in the body. BrendaTissueOBO BTO:0000206 cartilage BTO:0000207 Cartilage pertaining to the tibia. BrendaTissueOBO BTO:0000207 tibial cartilage BTO:0000208 Simple, dry, indehiscent fruit with a single seed that is fused to the ovary wall, example: wheat. BrendaTissueOBO grain BTO:0000208 caryopsis BTO:0000211 One of the centrally-located portions of the brain affected by Huntington's Disease. Speech and swallowing problems arise when this region and another region called the putamen are affected. BrendaTissueOBO caudatum nucleus caudatus BTO:0000211 caudate nucleus BTO:0000216 BrendaTissueOBO BTO:0000216 culture condition BTO:0000218 The BALB/3T3 clone A31 is one of several cell lines (see BALB/3T12) developed in 1968 from disaggregated 14- to 17-day-old BALB/c mouse embryos. BrendaTissueOBO BALB/3T3 clone A31 BALB/c 3T3 cell BALBc/3T3 cell BTO:0000218 BALB/3T3 cell BTO:0000219 The ventral part of the shell of a turtle or tortoise. XPMUser 2013-02-28T12:04:31Z BrendaTissueOBO BTO:0000219 plastron BTO:0000222 An embryonic cell that becomes a cell of muscle fiber. BrendaTissueOBO sarcoblast BTO:0000222 myoblast BTO:0000223 A malignant tumor cell of the testis composed of teratoma and embryonal carcinoma. BrendaTissueOBO BTO:0000223 teratocarcinoma cell BTO:0000224 BrendaTissueOBO BTO:0000224 liver cell line BTO:0000225 CEM is a camptothecin (CPT) resistant derivative of the human T cell leukemia cell line CCRF-CEM. The cell line was selected and subcloned in 1991 for resistance to CPT. Established from an 4-year-old caucasian female. BrendaTissueOBO BTO:0000225 CEM cell BTO:0000227 The central nervous system is that part of the nervous system that consists of the brain and spinal cord. The central nervous system (CNS) is one of the two major divisions of the nervous system. The other is the peripheral nervous system (PNS) which is outside the brain and spinal cord. BrendaTissueOBO CNS cerebrospinal axis neuraxis BTO:0000227 central nervous system BTO:0000228 Mouse neuroblastoma cell line. BrendaTissueOBO C1300 cell BTO:0000228 C-1300 cell BTO:0000232 A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe. BrendaTissueOBO BTO:0000232 cerebellum BTO:0000233 The surface layer of gray matter of the cerebrum that functions chiefly in coordination of sensory and motor information. BrendaTissueOBO brain cortex cortex of cerebral hemisphere pallium of the brain BTO:0000233 cerebral cortex BTO:0000234 Any of the tubular branching vessels that carry blood from the capillaries toward the heart. BrendaTissueOBO venous vessel BTO:0000234 vein BTO:0000235 Any of four deeply placed masses of gray matter (as the amygdala) in each cerebral hemisphere. Location: The basal ganglion is located deep within the cerebral hemispheres in the telencephalon region of the brain. It consists of the corpus stratium, subthalamic nucleus and the substantia nigra. BrendaTissueOBO basal nucleus BTO:0000235 basal ganglion BTO:0000236 Whitish nerve tissue, especially of the brain and spinal cord, consisting chiefly of myelinated nerve fibers. BrendaTissueOBO white matter BTO:0000236 cerebral white matter BTO:0000238 Endothelial cell of or involving the cerebrum and the blood vessels supplying it. BrendaTissueOBO BTO:0000238 cerebrovascular endothelial cell BTO:0000243 A canal in a female mammal that leads from the uterus to the external orifice of the genital canal. BrendaTissueOBO BTO:0000243 vagina BTO:0000247 The terminal bud (0.1 - 1.0 mm) of a plant, which consists of the apical meristem (0.05 - 0.1 mm) and the immediate surrounding leaf primordia and developing leaves and adjacent stem tissue. BrendaTissueOBO shoot apex BTO:0000247 shoot tip BTO:0000250 Chondrosarcoma is a malignant tumor derived from cartilage cells or their precursors, but lacking direct osteoid formation; it occurs predominantly in the pelvis, femur, and shoulder girdle in middle-aged to older adults. It may be primary, arising from cartilage cells, or secondary to a pre-existing benign lesion. BrendaTissueOBO BTO:0000250 chondrosarcoma cell BTO:0000251 A vascular fetal membrane composed of the fused chorion and adjacent wall of the allantois that in the hen's egg is used as a living culture medium for viruses and for tissues. BrendaTissueOBO chorioallantoic membrane BTO:0000251 chorioallantois BTO:0000254 BrendaTissueOBO BTO:0000254 female reproductive gland BTO:0000255 BrendaTissueOBO BTO:0000255 brain cell line BTO:0000256 BrendaTissueOBO BTO:0000256 myoblast cell line BTO:0000257 BrendaTissueOBO BTO:0000257 uterine cancer cell BTO:0000258 The choroid plexus is tissue located in the spaces inside the brain called ventricles. The choroid plexus makes the fluid that fills the ventricles and surrounds the brain and spinal cord. BrendaTissueOBO BTO:0000258 choroid plexus BTO:0000259 A type of amine precursor uptake and decarboxylation cells that stain readily with chromium salts, their cytoplasmic granules taking on a characteristic brown color; they are found especially in cells of the adrenal medulla and in paraganglia of the coccygeal gland and carotid gland, along the sympathetic nerves, and in various organs. They contain chromaffin granules. BrendaTissueOBO pheochrome cell pheochromocytes BTO:0000259 chromaffin cell BTO:0000260 Tissue that includes the group of muscles that act on the eye lens to produce accommodation and the arterial circle of the iris. The inner ciliary epithelium is continuous with the pigmented retinal epithelium, the outer ciliary epithelium secretes the aqueous humour. BrendaTissueOBO BTO:0000260 ciliary body BTO:0000262 One of the small bulbs (as in garlic) developed in the axils of the scales of a large bulb. BrendaTissueOBO BTO:0000262 clove BTO:0000264 BrendaTissueOBO BTO:0000264 bone marrow cell line BTO:0000265 BrendaTissueOBO BTO:0000265 coagulating gland BTO:0000266 The central axis/core of the ear (distal end of the lateral branch/ear shoot) upon which the kernels (caryopses) are borne. The cob is similar to the central spike of the tassel (male inflorescence) in that it produces multiple rows of paired spikelets (polystichous phyllotaxy). BrendaTissueOBO corn cob corn ear corncob maize cob BTO:0000266 Zea mays. cob BTO:0000269 The part of the large intestine that extends from the cecum to the rectum. BrendaTissueOBO BTO:0000269 colon BTO:0000273 The ink gland and ink sac are specializations of the rectal gland. BrendaTissueOBO BTO:0000273 ink gland BTO:0000275 BrendaTissueOBO BTO:0000275 colonocyte BTO:0000279 Cancer that forms in tissues of the testis. Testicular cancer usually occurs in young or middle-aged men. Two main types of testicular cancer are seminomas (cancers that grow slowly and are sensitive to radiation therapy) and nonseminomas (different cell types that grow more quickly than seminomas). BrendaTissueOBO testicular carcinoma cell BTO:0000279 testicular cancer cell BTO:0000280 A mass of ovule-bearing or pollen-bearing scales or bracts in trees of the pine family or in cycads that are arranged usually on a somewhat elongated axis. BrendaTissueOBO BTO:0000280 cone BTO:0000282 The upper or anterior division of the animal body that contains the brain, the chief sense organs, and the mouth. BrendaTissueOBO BTO:0000282 head BTO:0000284 BrendaTissueOBO Gestalt BTO:0000284 organism form BTO:0000286 The transparent part of the coat of the eyeball that covers the iris and pupil and admits light to the interior. BrendaTissueOBO BTO:0000286 cornea BTO:0000287 Posterior epithelium of cornea: the mesothelial layer covering the posterior surface of the posterior limiting lamina of the cornea; it was once believed to extend to the anterior surface of the stroma of the iris. BrendaTissueOBO anterior endothelium of cornea corneal endothelium endothelium anterius corneae endothelium camerae anterioris bulbi endothelium corneale epithelium posterius corneae BTO:0000287 corneal epithelium BTO:0000289 Subset of T-lymphocytes (mostly CD8+) responsible for lysing target cells and for killing virus-infected cells. BrendaTissueOBO CTL cytolytic T-cell cytolytic T-lymphocyte cytotoxic T-cell killer T-cell killer T-lymphocyte BTO:0000289 cytotoxic T-lymphocyte BTO:0000290 Either of two arteries that arise one from the left and one from the right side of the aorta immediately above the semilunar valves and supply the tissues of the heart itself. BrendaTissueOBO BTO:0000290 coronary artery BTO:0000291 One of a pair of separate or fused bodies in many insects that are sometimes closely associated with the corpora cardiaca and that secrete hormones (as juvenile hormone). BrendaTissueOBO corpora allata BTO:0000291 corpus allatum BTO:0000293 This lobe is located at the back of the head and is involved in vision and reading. BrendaTissueOBO occipital cortex BTO:0000293 occipital lobe BTO:0000297 BrendaTissueOBO BTO:0000297 carcinoma cell line BTO:0000298 African green monkey kidney derived from CV-1, a simian cell line (cercopithecus aethiops), by transformation with an origin-defective mutant of SV-40; cells were described to support the growth of SV-40 viruses. BrendaTissueOBO COS7 cell BTO:0000298 COS-7 cell BTO:0000299 Each seed of a cotton plant is surrounded with downy fiber, white or creamy in color and easily spun. The fibers flatten and twist naturally as they dry. BrendaTissueOBO cotton fiber BTO:0000299 cotton fibre BTO:0000303 A disease that affects many species of plants and is caused by a bacterium (Agrobacterium tumefaciens) which forms tumorous enlargements just below the ground on the stem. BrendaTissueOBO BTO:0000303 crown gall BTO:0000304 Human, Caucasian, pancreas, carcinoma cell line. Established from a pancreatic carcinoma of ductal origin from a 56-year-old Caucasian male. Cells possess the type B phenotype for G6PD. BrendaTissueOBO BTO:0000304 PANC-1 cell BTO:0000305 A crypt is a deep pit that protrudes down into the connective tissue surrounding the small intestine. The epithelium at the base of the crypt is the site of stem cell proliferation and the differentiated cells move upwards and are shed 3-5 days later at the tips of the villi. BrendaTissueOBO BTO:0000305 crypt BTO:0000306 BrendaTissueOBO BTO:0000306 teratocarcinoma cell line BTO:0000312 A neuron with a motor function; an efferent neuron conveying motor impulses. BrendaTissueOBO motor neuron BTO:0000312 motoneuron BTO:0000313 The outer cellular layer of the body of invertebrates which secretes the cuticular exoskeleton. BrendaTissueOBO hypoderm BTO:0000313 hypodermis BTO:0000314 1: Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. 2: The epithelium of the ectoderm, from which the central nervous system is developed. BrendaTissueOBO sensory epithelium BTO:0000314 neuroepithelium BTO:0000315 The outer of the three germ layers of the embryo (the other two being mesoderm and endoderm). Ectoderm gives rise to epidermis and neural tissue. BrendaTissueOBO BTO:0000315 ectoderm BTO:0000318 Normal kidney cell line. The CV-1 cell line was derived from the kidney of a male adult African green monkey by F.C. Jensen, et al in March, 1964 for use in Rous sarcoma virus transformation studies. BrendaTissueOBO CV 1 cell CV1 cell BTO:0000318 CV-1 cell BTO:0000320 A body resembling a cyst: as a 1: capsule formed about a minute organism going into a resting or spore stage; also: this capsule with its contents. 2: a resistant cover about a parasite produced by the parasite or the host. BrendaTissueOBO BTO:0000320 cyst BTO:0000331 Mouse connective tissue fibroblast, established from the normal subcutaneous areolar and adipose tissue of a male C3H/An mouse; used as target in TNF detection assays. BrendaTissueOBO L cell L-cell L929 cell NCTC clone 929 BTO:0000331 L-929 cell BTO:0000339 The soft sensitive tissue that fills the central cavity of a tooth. BrendaTissueOBO dental pulp cell BTO:0000339 dental pulp BTO:0000345 A gland, such as the liver or pancreas, that secretes into the alimentary canal substances necessary for digestion. BrendaTissueOBO BTO:0000345 digestive gland BTO:0000346 BrendaTissueOBO digestive fluid BTO:0000346 digestive juice BTO:0000347 The second compartment of the stomach of a ruminant in which folds of the mucous membrane form hexagonal cells. BrendaTissueOBO BTO:0000347 reticulum BTO:0000353 BrendaTissueOBO BTO:0000353 lung cell line BTO:0000356 BrendaTissueOBO breast carcinoma cell line BTO:0000356 breast cancer cell line BTO:0000362 Cancer cell of the organ responsible for temporarily holding urine after it leaves the kidneys. BrendaTissueOBO bladder cancer cell bladder carcinoma cell bladder tumour cell urinary bladder carcinoma cell BTO:0000362 urinary bladder cancer cell BTO:0000364 A thin somewhat translucent layer of cells lying superficial to the stratum granulosum and under the stratum corneum especially in thickened parts of the epidermis. BrendaTissueOBO BTO:0000364 stratum lucidum BTO:0000365 The first part of the small intestine extending from the pylorus to the jejunum. BrendaTissueOBO anterior intestine proximal intestine upper intestine BTO:0000365 duodenum BTO:0000368 The organ of hearing. BrendaTissueOBO auditory apparatus auditory system auris BTO:0000368 ear BTO:0000371 The yellow spheroidal mass of stored food that forms the inner portion of the egg of a bird or reptile and is surrounded by the white. BrendaTissueOBO yolk BTO:0000371 egg yolk BTO:0000372 Cancer cell of the skeleton. Cancers that begin in bone are rare but it is not unusual for cancers to spread (metastasize) to bone from other parts of the body. This is not called bone cancer, but is named for the organ or tissue in which the cancer begins. BrendaTissueOBO bone tumor cell BTO:0000372 bone cancer cell BTO:0000373 Mouse cancer cell. BrendaTissueOBO EAT cell Ehrlich ascites tumor cell BTO:0000373 Ehrlich ascites carcinoma cell BTO:0000374 BrendaTissueOBO BTO:0000374 bone cell line BTO:0000375 BrendaTissueOBO KC BTO:0000375 keratinocyte cell line BTO:0000376 A specialized tract of tissue (as in the electric eel) in which electricity is generated. BrendaTissueOBO BTO:0000376 electric organ BTO:0000379 An animal in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems; especially: the developing human individual from the time of implantation to the end of the eighth week after conception. BrendaTissueOBO BTO:0000379 embryo BTO:0000381 BrendaTissueOBO BTO:0000381 embryonic blood BTO:0000383 BrendaTissueOBO RCC cell line hypernephroma cell line kidney adenocarcinoma cell line renal cell adenocarcinoma cell line BTO:0000383 renal cell carcinoma cell line BTO:0000385 BrendaTissueOBO BTO:0000385 bone cancer cell line BTO:0000387 A thin serous membrane lining the cavities of the heart. BrendaTissueOBO BTO:0000387 endocardium BTO:0000390 A triploid nutritive tissue resulting from the fusion of a haploid sperm nucleus with the two haploid polar nuclei in the ovule of angiosperms. BrendaTissueOBO BTO:0000390 endosperm BTO:0000391 Human colon adenocarcinoma established from a colorectal adenocarcinoma. BrendaTissueOBO BTO:0000391 DLD-1 cell BTO:0000392 A terminally differentiated cell of the B lymphocyte lineage that produces antibodies; plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern. BrendaTissueOBO plasmacyte plasmocyte BTO:0000392 plasma cell BTO:0000393 An epithelium of mesodermal origin composed of a single layer of thin flattened cells that lines internal body cavities. BrendaTissueOBO BTO:0000393 endothelium BTO:0000394 Simple squamous epithelium which lines the lumen side of the blood vessel. BrendaTissueOBO aortic endothelium BTO:0000394 aorta endothelium BTO:0000395 Any cell of the walls of the pulmonary alveoli; the term is often limited to alveolar epithelial cells (type I and type II alveolar cells) and alveolar macrophages. BrendaTissueOBO pneumocyte pneumonocyte BTO:0000395 alveolar cell BTO:0000397 1: One of the hard bony appendages that are borne on the jaws or in many of the lower vertebrates on other bones in the walls of the mouth or pharynx and serve especially for the prehension and mastication of food and as weapons of offense and defense. 2: Any of various usually hard and sharp processes especially about the mouth of an invertebrate. BrendaTissueOBO BTO:0000397 tooth BTO:0000399 A white blood cell or other granulocyte with cytoplasmic inclusions readily stained by eosin. BrendaTissueOBO eosinocyte eosinophil granulocyte eosinophilic leucocyte eosinophilic leukocyte BTO:0000399 eosinophil BTO:0000400 BrendaTissueOBO BTO:0000400 sarcoma cell line BTO:0000403 BrendaTissueOBO BTO:0000403 mastocytoma cell line BTO:0000405 A male organ of copulation that in male mammals including humans usually functions as the channel by which urine leaves the body. BrendaTissueOBO phallus BTO:0000405 penis BTO:0000406 Human Hodgkin's lymphoma, established from the pleural effusion of a 37-year-old woman with Hodgkin's lymphoma (stage IVB, nodular sclerosis, refractory, terminal) in 1978. BrendaTissueOBO L428 cell BTO:0000406 L-428 cell BTO:0000407 Cell line of a malignant neoplasm of the bone-forming tissues. BrendaTissueOBO osteoblastic sarcoma cell line osteogenic sarcoma cell line BTO:0000407 osteosarcoma cell line BTO:0000408 A system of ductules emerging posteriorly from the testis that holds sperm during maturation and that forms a tangled mass before uniting into a single coiled duct which is continuous with the vas deferens. BrendaTissueOBO Epididymus Nebenhoden BTO:0000408 epididymis BTO:0000409 Any of the bodies representing the morphologic (crithidial) stage in the life cycle of certain trypanosomatid protozoa resembling the typical adult form of members of the genus Crithidia, in which the kinetoplast and basal body are located anterior to the central vesicular nucleus of the slender elongate cell and the flagellum is attached to the body up to the anterior end by a short undulating membrane before becoming free-flowing. BrendaTissueOBO BTO:0000409 epimastigote BTO:0000412 The disk or plate of cartilage interposed between the epiphysis and the shaft of the bone during the period of growth; by its growth the bone increases in length. BrendaTissueOBO cartilago epiphysialis epiphyseal cartilage epiphyseal disk epiphyseal growth disk growth plate physis BTO:0000412 epiphyseal growth plate BTO:0000414 Cell that cover the surface of the body and line its cavities. BrendaTissueOBO BTO:0000414 epithelial cell BTO:0000415 A neoplasm cell of epithelial origin, ranging from benign (adenoma and papilloma) to malignant (carcinoma). BrendaTissueOBO BTO:0000415 epithelioma cell BTO:0000416 A membranous cellular tissue that covers a free surface or lines a tube or cavity of an animal body and serves especially to enclose and protect the other parts of the body, to produce secretions and excretions, and to function in assimilation. BrendaTissueOBO BTO:0000416 epithelium BTO:0000419 Epithelium of the respiratory portion of the bronchial tree. BrendaTissueOBO airway epithelium BTO:0000419 respiratory epithelium BTO:0000421 The tissue which binds together and is the support of the various structures of the body. It is made up of fibroblasts, fibroglia, collagen fibrils, and elastic fibrils. It is derived from the mesoderm and in a broad sense includes the collagenous, elastic, mucous, reticular, osseous, and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to concentration of fibers as loose (areolar) and dense, the latter having more abundant fibers than the former. BrendaTissueOBO Bindegewebe BTO:0000421 connective tissue BTO:0000424 Any of the hemoglobin-containing cells that carry oxygen to the tissues and are responsible for the red color of vertebrate blood. BrendaTissueOBO RBC red blood cell red blood corpuscle BTO:0000424 erythrocyte BTO:0000426 Cancer cell of the blood-forming tissues in which large numbers of immature, abnormal red blood cells are found in the blood and bone marrow. BrendaTissueOBO BTO:0000426 erythroleukemia cell BTO:0000427 BrendaTissueOBO BTO:0000427 pituitary gland cell line BTO:0000431 A gland that discharges its secretion through a duct opening on an internal or external surface of the body, as a lacrimal gland. BrendaTissueOBO BTO:0000431 excretory gland BTO:0000432 A pair of neurohemal organs located on the walls of the aorta just behind the brain. The corpora cardiaca release their store of PTTH only after they receive a signal from neurosecretory cells in the brain. BrendaTissueOBO corpora cardiaca BTO:0000432 corpus cardiacum BTO:0000439 An organ of sight; especially: a nearly spherical hollow organ that is lined with a sensitive retina, is lodged in a bony orbit in the skull, is the vertebrate organ of sight, and is normally paired. BrendaTissueOBO visual apparatus visual system BTO:0000439 eye BTO:0000442 A fatty tissue especially of nearly mature insect larvae that serves as a food reserve. BrendaTissueOBO BTO:0000442 fat body BTO:0000443 One of the fat-laden cells making up adipose tissue. BrendaTissueOBO fat cell lipocyte BTO:0000443 adipocyte BTO:0000444 An accumulation of adipose tissue (fat cells) enclosed in fibrous tissue. BrendaTissueOBO BTO:0000444 fat pad BTO:0000447 Any of the light horny epidermal outgrowths that form the external covering of the body of birds and that consist of a shaft bearing on each side a series of barbs which bear barbules which in turn bear barbicels commonly ending in hooked hamuli and interlocking with the barbules of an adjacent barb to link the barbs into a continuous vane. BrendaTissueOBO BTO:0000447 feather BTO:0000449 An unborn or unhatched vertebrate especially after attaining the basic structural plan of its kind; specifically: a developing human from usually three months after conception to birth. BrendaTissueOBO embryo late growth stage embryo late stage BTO:0000449 fetus BTO:0000450 An elongated tapering thick-walled plant cell void at maturity that imparts elasticity, flexibility, and tensile strength. BrendaTissueOBO BTO:0000450 American Cotton (Gossypium hirsutum). fiber BTO:0000452 A connective-tissue cell of mesenchymal origin that secretes proteins and especially molecular collagen from which the extracellular fibrillar matrix of connective tissue forms. BrendaTissueOBO BTO:0000452 fibroblast BTO:0000453 BrendaTissueOBO FCL BTO:0000453 fibroblast cell line BTO:0000457 Chinese hamster ovary cells, subclone from parental CHO cell line that was initiated from an ovary biopsy of an adult Chinese hamster in 1957. BrendaTissueOBO BTO:0000457 CHO-K1 cell BTO:0000459 Fibrosarcoma is a malignant tumour derived from connective tissue fibroblast. BrendaTissueOBO fibroblastic sarcoma cell BTO:0000459 fibrosarcoma cell BTO:0000460 BrendaTissueOBO BTO:0000460 fibrosarcoma cell line BTO:0000461 Mouse Swiss Albino fibrosarcoma cell line. BrendaTissueOBO BTO:0000461 HSDM1C1 cell BTO:0000463 Part of the stamen in a flower that supports the anther. A chainlike series of cells, as in many algae. BrendaTissueOBO BTO:0000463 filament BTO:0000464 A flagellate protozoan or alga. BrendaTissueOBO BTO:0000464 flagellate BTO:0000467 BrendaTissueOBO BTO:0000467 flight muscle BTO:0000468 1. A small or reduced flower, especially one of the grasses and composite plants, such as a daisy. 2. Any of the tight, branched clusters of flower buds that together form a head of cauliflower or broccoli. BrendaTissueOBO BTO:0000468 floret BTO:0000469 The reproductive structure of the anthophyta or angiosperms. BrendaTissueOBO BTO:0000469 flower BTO:0000472 Mouse mammary carcinoma cell line. BrendaTissueOBO BTO:0000472 FM3A cell BTO:0000473 Any membrane that functions for the protection or nourishment of respiration or excretion of a developing fetus. BrendaTissueOBO BTO:0000473 fetal membrane BTO:0000474 A vascular fetal membrane of reptiles, birds, and mammals that is formed as a pouch from the hindgut and that in placental mammals is intimately associated with the chorion in formation of the placenta. BrendaTissueOBO BTO:0000474 allantois BTO:0000476 1: The terminal part of the vertebrate leg upon which an individual stands. 2: An invertebrate organ of locomotion or attachment; especially: a ventral muscular surface or process of a mollusk. BrendaTissueOBO BTO:0000476 foot BTO:0000480 Any of the first three stomachs of a ruminant, i.e., the rumen, reticulum, or omasum. BrendaTissueOBO BTO:0000480 forestomach BTO:0000483 A large leaf (especially of a palm or fern) usually with many divisions. BrendaTissueOBO BTO:0000483 frond BTO:0000484 Front part of the brain, involved in planning, organizing, problem solving, selective attention, personality and a variety of higher cognitive functions including behavior and emotions. BrendaTissueOBO frontal cortex BTO:0000484 frontal lobe BTO:0000486 The mature ovary or ovaries of a seed-bearing plant, together with accessory parts, containing the seeds and occurring in a wide variety of forms. BrendaTissueOBO BTO:0000486 fruit BTO:0000491 The matter, such as urine or sweat, that is excreted from the blood, tissues, or organs. BrendaTissueOBO BTO:0000491 excretion BTO:0000493 A small, pear-shaped muscular sac, located under the right lobe of the liver, in which bile secreted by the liver is stored until needed by the body for digestion. BrendaTissueOBO gallbladder BTO:0000493 gall bladder BTO:0000495 The individual or generation of a plant exhibiting alternation of generations that bears sex organs. BrendaTissueOBO BTO:0000495 gametophyte BTO:0000497 A group of nerve cell bodies located outside the central nervous system. The term is occasionally applied to certain nuclear groups within the brain or spinal cord, such as the basal ganglia. BrendaTissueOBO neural ganglion BTO:0000497 ganglion BTO:0000498 Gastric cancer is a cancer of the stomach. BrendaTissueOBO stomach cancer cell stomach carcinoma cell BTO:0000498 gastric cancer cell BTO:0000501 A thin watery acid digestive fluid secreted by glands in the mucous membrane of the stomach. BrendaTissueOBO succus gastricus BTO:0000501 gastric juice BTO:0000504 The liquid secretion of the exocrine pancreas, which is discharged into the duodenum. BrendaTissueOBO succus pancreaticus BTO:0000504 pancreatic juice BTO:0000510 The caudal portion of the embryonic alimentary canal in vertebrates. BrendaTissueOBO BTO:0000510 hindgut BTO:0000514 A small mass of living substance capable of developing into an organism or one of its parts. BrendaTissueOBO BTO:0000514 germ BTO:0000518 A paired respiratory organ in fishes consisting of gill filaments on the gill arch in the posterior portion of the head and usually providing the primary exchange of gases between the blood and the surrounding water. BrendaTissueOBO branchia branchial tissue BTO:0000518 gill BTO:0000519 The tissue that surrounds the necks of teeth and covers the alveolar parts of the jaws; broadly: the alveolar portion of a jaw with its enveloping soft tissues. BrendaTissueOBO gum BTO:0000519 gingiva BTO:0000520 1: The muscular enlargement of the alimentary canal of birds that has usually thick muscular walls and a tough horny lining for grinding the food and when the crop is present follows it and the proventriculus. 2: A thickened part of the alimentary canal in some animals (as an insect or an earthworm) that is similar in function to the crop of a bird. BrendaTissueOBO BTO:0000520 gizzard BTO:0000522 A cell, group of cells, or organ of endothelial origin that selectively removes materials from the blood, concentrates or alters them, and secretes them for further use in the body or for elimination from the body. BrendaTissueOBO Druese glandula BTO:0000522 gland BTO:0000524 The delicate network of branched cells and fibers that supports the tissue of the central nervous system. BrendaTissueOBO neuroglia BTO:0000524 glia BTO:0000526 A tumor cell originating in the neuroglia of the brain or spinal cord. BrendaTissueOBO neurogliocytoma cell neuroglioma cell neurospongioma cell BTO:0000526 glioma cell BTO:0000527 Glioblastoma is a general term for malignant forms of astrocytoma. BrendaTissueOBO BTO:0000527 glioblastoma cell BTO:0000529 The glial cell strain, C6, was cloned from a rat glial tumor induced by N-nitrosomethylurea by Benda et al after a series of alternate culture and animal passages. Tissue: brain; glial cell; glioma. Morphology: fibroblast. BrendaTissueOBO C6 cell rat glioblastoma C6 cell BTO:0000529 C6 glioma cell BTO:0000534 A reproductive gland (as an ovary or testis) that produces gametes. BrendaTissueOBO BTO:0000534 gonad BTO:0000535 1. A gamete (as an egg or sperm cell) or one of its antecedent cells. 2. A mature male or female germ cell usually possessing a haploid chromosome set and capable of initiating formation of a new diploid individual by fusion with a gamete of the opposite sex. BrendaTissueOBO gamete BTO:0000535 germ cell BTO:0000536 The Gracilis is the most superficial muscle on the medial side of the thigh. It is thin and flattened, broad above, narrow and tapering below. It arises by a thin aponeurosis from the anterior margins of the lower half of the symphysis pubis and the upper half of the pubic arch. The fibers run vertically downward, and end in a rounded tendon, which passes behind the medial condyle of the femur, curves around the medial condyle of the tibia, where it becomes flattened, and is inserted into the upper part of the medial surface of the body of the tibia, below the condyle. BrendaTissueOBO gracilis BTO:0000536 gracilis muscle BTO:0000538 Pleomorphic cells of the pulmonary alveolar epithelium that secrete surfactant and are distinguished by abundant cytoplasm containing numerous lipid-rich multilamellar bodies. BrendaTissueOBO T2 cell alveolar T2 cell alveolar cell type 2 alveolar type 2 cell alveolar type II cell granular pneumonocyte great alveolar cell large alveolar cell type 2 pneumocyte BTO:0000538 alveolar cell type II BTO:0000539 A polymorphonuclear white blood cell with granule-containingcytoplasm. In humans the granulocytes are also classified as polymorphonuclear leucocytes and are subdivided according to the staining properties of the granules into eosinophils, basophils and neutrophils, some invertebrate blood cells are also referred to, not very helpfully, as granulocytes. BrendaTissueOBO BTO:0000539 granulocyte BTO:0000542 One of the estrogen-secreting cells of the epithelial lining of a graafian follicle or its follicular precursor. BrendaTissueOBO ovarian granulosa cell BTO:0000542 granulosa cell BTO:0000545 1: The alimentary canal or a portion thereof, especially the intestine or stomach. 2: The embryonic digestive tube, consisting of the foregut, the midgut, and the hindgut. BrendaTissueOBO BTO:0000545 gut BTO:0000546 BrendaTissueOBO BTO:0000546 gut mucosa BTO:0000551 Cancer cell of the major organ of respiration the lung. BrendaTissueOBO lung carcinoma cell BTO:0000551 lung cancer cell BTO:0000552 HaCaT is a spontaneously immortalized human keratinocyte cell line. BrendaTissueOBO BTO:0000552 HaCaT cell BTO:0000553 Blood circulating throughout the body. BrendaTissueOBO BTO:0000553 peripheral blood BTO:0000554 The tubular epithelial sheath that surrounds the lower part of the hair shaft and encloses at the bottom a vascular papilla supplying the growing basal part of the hair with nourishment. BrendaTissueOBO BTO:0000554 hair follicle BTO:0000556 A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. BrendaTissueOBO BTO:0000556 germ layer BTO:0000562 1: A hollow muscular organ of vertebrate animals that by its rhythmic contraction acts as a force pump maintaining the circulation of the blood. 2: A structure in an invertebrate animal functionally analogous to the vertebrate heart. BrendaTissueOBO Herz BTO:0000562 heart BTO:0000566 BrendaTissueOBO BTO:0000566 pancreatic islet cancer cell BTO:0000567 Human cervix carcinoma established from the epitheloid cervix carcinoma of a 31-year-old black woman in 1951. Later diagnosis changed to adenocarcinoma, first aneuploid, continuously cultured human cell line. BrendaTissueOBO HELA cell BTO:0000567 HeLa cell BTO:0000568 Human cervix carcinoma cell line is a subclone of its parent HELA derived in 1955. BrendaTissueOBO HeLa S3 cell BTO:0000568 HeLa-S3 cell BTO:0000569 The spozoites move to the liver, enter liver cells and replicate asexually through schizogony. This is the exoerythrocytic stage. BrendaTissueOBO BTO:0000569 exoerythrocytic stage BTO:0000573 Any of the tubular branching muscular- and elastic-walled vessels that carry blood from the heart through the body. BrendaTissueOBO arterial vessel BTO:0000573 artery BTO:0000574 A blood cell. BrendaTissueOBO blood cell haematopoietic cell haemopoietic cell hemopoietic cell BTO:0000574 hematopoietic cell BTO:0000578 BrendaTissueOBO HCC cell line hepatocarcinoma cell line hepatocellular carcinoma cell line BTO:0000578 hepatoma cell line BTO:0000579 A cell of a cancerous growth in any part of the eye. BrendaTissueOBO BTO:0000579 eye cancer cell BTO:0000580 The major forms of blood cancer are lymphoma, leukemia and multiple myeloma. They affect the way a body makes blood and provides immunity from other diseases. BrendaTissueOBO BTO:0000580 blood cancer cell BTO:0000583 BrendaTissueOBO BTO:0000583 bone marrow cancer cell BTO:0000584 Pancreatic cancer is a disease in which malignant (cancer) cells are found in the tissues of the pancreas. BrendaTissueOBO exocrine cancer cell pancreatic adenocarcinoma cell pancreatic carcinoma cell BTO:0000584 pancreatic cancer cell BTO:0000586 A malignant tumour arising from the inner wall of the large intestine. BrendaTissueOBO carcinoma cell, colon colon cancer cell colon carcinoma cell colonic carcinoma cell BTO:0000586 colonic cancer cell BTO:0000589 Meristem (as procambium) derived from the apical meristem. BrendaTissueOBO BTO:0000589 primary meristem BTO:0000590 Alzheimer is a disease marked by the loss of cognitive ability, generally over a period of 10 to 15 years, and associated with the development of abnormal tissues and protein deposits in the cerebral cortex. BrendaTissueOBO Alzheimer specific cell type BTO:0000590 Alzheimer disease specific cell type BTO:0000592 Adrenal gland cancers are rare cancers occuring in the endocrine tissue of the adrenals. They are characterized by overproduction of adrenal gland hormones. BrendaTissueOBO adrenal gland tumor cell BTO:0000592 adrenal gland cancer cell BTO:0000594 Malignant (cancer) cells are found in the tissues of the liver. BrendaTissueOBO BTO:0000594 liver cancer cell BTO:0000596 Mouse embryonal carcinoma cell line, established from the teratocarcinoma induced in a C3H/He strain mouse. BrendaTissueOBO P19 cell BTO:0000596 P-19 cell BTO:0000600 A large transparent thick-walled cell that is found in the filaments of some blue-green algae and is the site of nitrogen fixation. BrendaTissueOBO BTO:0000600 heterocyst BTO:0000601 A curved elongated ridge that extends over the floor of the descending horn of each lateral ventricle of the brain and consists of gray matter covered on the ventricular surface with white matter; The hippocampus is a part of the temporal lobe, which has a well established role in learning, memory and emotion. BrendaTissueOBO hippocampus major major hippocampus BTO:0000601 hippocampus BTO:0000604 A cell of a cancer that begins in cells that line certain internal organs and that have glandular (secretory) properties. BrendaTissueOBO BTO:0000604 adenocarcinoma cell BTO:0000605 A sweet viscid material elaborated out of the nectar of flowers in the honey sac of various bees. BrendaTissueOBO BTO:0000605 honey BTO:0000608 Primary carcinoma of the liver cells. It ranges from a well-differentiated tumour difficult to distinguish from normal hepatocytes to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic or may form giant cells. Several classification schemes have been suggested. Hepatocellular carcinoma is very rare in the united states and western europe, but it is one of the most common cancers in eastern asia and sub-saharan africa. The cases are preponderantly male and, racially, whites have the lowest rates. BrendaTissueOBO HCC cell hepatic cancer cell hepatic carcinoma cell hepatocarcinoma cell hepatocellular adenocarcinoma cell hepatocellular carcinoma cell liver adenocarcinoma cell BTO:0000608 hepatoma cell BTO:0000614 The ventral part of the diencephalon that forms the floor and part of the lateral wall of the third ventricle. Anatomically, it includes the preoptic area, optic tract, optic chiasm, mammillary bodies, tuber cinereum, infundibulum, and neurohypophysis, but for physiological purposes the neurohypophysis is considered a distinct structure. The hypothalamus may be divided into five regions or areas (area hypothalamica rostralis, area hypothalamica dorsalis, area hypothalamica intermedia, area hypothalamica lateralis and area hypothalamica posterior) or into three longitudinal zones (periventricular zone, medial zone, and lateral zone). The hypothalamic nuclei constitute that part of the corticodiencephalic mechanism that activates, controls and integrates the peripheral autonomic mechanisms, endocrine activity, and many somatic functions, e.g., a general regulation of water balance, body temperature, sleep, and food intake, and the development of secondary sex characteristics. The hypothalamus secretes vasopressin and oxytocin, which are stored in the pituitary, as well as many releasing factors (hypophysiotropic hormones), by means of which it exerts control over functions of the adenohypophysis. BrendaTissueOBO BTO:0000614 hypothalamus BTO:0000615 The great band of commissural fibers uniting the cerebral hemispheres of higher mammals including humans. BrendaTissueOBO BTO:0000615 corpus callosum BTO:0000619 BrendaTissueOBO BTO:0000619 ileal mucosa BTO:0000620 The last division of the small intestine extending between the jejunum and large intestine. BrendaTissueOBO distal intestine intestinum ileum lower intestine posterior intestine BTO:0000620 ileum BTO:0000628 A flower cluster with a definite arrangement. BrendaTissueOBO flower cluster BTO:0000628 inflorescence BTO:0000629 The black protective secretion of a cephalopod; The ink is composed mostly of melanin and has been used as the artists pigment, sepia. BrendaTissueOBO BTO:0000629 ink BTO:0000630 The essential organ of hearing and equilibrium that is located in the temporal bone, is innervated by the auditory nerve, and includes the vestibule, the semicircular canals, and the cochlea. BrendaTissueOBO auris interna internal ear BTO:0000630 inner ear BTO:0000632 A cell of a usually benign tumor of the insulin-secreting cells of the pancreas. BrendaTissueOBO BTO:0000632 insulinoma cell BTO:0000634 Something that covers or encloses; especially: an enveloping layer (as a skin, membrane, or husk) of an organism or one of its parts. BrendaTissueOBO Hautsystem dermal system dermoid system integumental system integumentary system tegument BTO:0000634 integument BTO:0000638 Interrenal cells in elasmobranchs and bony fishes represent the equivalent of the mammalian adrenal cortex. The interrenal cells' appearance varies greatly in response to stress and reproduction. These cells produce corticosteroids with cortisol being the most quantitatively important. BrendaTissueOBO BTO:0000638 interrenal cell BTO:0000639 The short intersegmental muscle is located between the prothorax and the mesothorax. BrendaTissueOBO BTO:0000639 intersegmental muscle BTO:0000642 The surface lining of the intestines where the cells absorb nutrients. BrendaTissueOBO BTO:0000642 intestinal mucosa BTO:0000643 BrendaTissueOBO intestinal smooth muscle BTO:0000643 intestinal muscle BTO:0000645 The S-shaped part of the colon which lies in the pelvis, extending from the pelvic brim to the third segment of the sacrum, and continuous above with the descending (or iliac) colon and below with the rectum. BrendaTissueOBO pelvic colon sigmoid colon sigmoid flexure BTO:0000645 colon sigmoideum BTO:0000648 The tubular part of the alimentary canal that extends from the stomach to the anus. BrendaTissueOBO bowel BTO:0000648 intestine BTO:0000651 The part of the intestine that lies between the stomach and colon, consists of duodenum, jejunum, and ileum, secretes digestive enzymes, and is the chief site of the absorption of digested nutrients. The proximal portion of the intestine. BrendaTissueOBO intestinum tenue BTO:0000651 small intestine BTO:0000653 The circular pigmented membrane behind the cornea, perforated by the pupil; the most anterior portion of the vascular tunic of the eye, it is made up of a flat bar of circular muscular fibers surrounding the pupil, a thin layer of smooth muscle fibers by which the pupil is dilated, thus regulating the amount of light entering the eye, and posteriorly two layers of pigmented epithelial cells. BrendaTissueOBO BTO:0000653 iris BTO:0000657 The section of the small intestine that comprises the first two fifths beyond the duodenum and that is larger, thicker-walled, and more vascular and has more circular folds than the ileum. BrendaTissueOBO intestinum jejunum mid intestine middle intestine BTO:0000657 jejunum BTO:0000658 The most common form of endometrial carcinoma, containing tumor cells differentiated into glandular tissue with little or no stroma. BrendaTissueOBO endometrial adenocarcinoma cell endometrial carcinoma cell endometrioid adenocarcinoma cell BTO:0000658 uterine adenocarcinoma cell BTO:0000659 The extractable fluid contents of cells or tissues. BrendaTissueOBO BTO:0000659 juice BTO:0000662 The upper part of the throat behind the nose. An opening on each side of the nasopharynx leads into the ear. BrendaTissueOBO Nasenrachenraum BTO:0000662 nasopharynx BTO:0000664 Human chronic myeloid leukemia in blast crisis established from the pleural effusion of a 53-year-old woman with chronic myeloid leukemia (CML) in blast crisis in 1970. BrendaTissueOBO K-562/S cell K562 cell K562s cell K562wt cell BTO:0000664 K-562 cell BTO:0000667 Skin cell, of the keratinized layer of epidermis: its characteristic intermediate filament protein is cytokeratin. A cell of the stratum spinosum of the epidermis. BrendaTissueOBO malpighian cell BTO:0000667 keratinocyte BTO:0000668 The inner softer part of a seed, fruit stone, or nut. BrendaTissueOBO BTO:0000668 kernel BTO:0000669 BrendaTissueOBO BTO:0000669 embryonic cell line BTO:0000671 1: One of a pair of vertebrate organs situated in the body cavity near the spinal column that excrete waste products of metabolism, in humans are bean-shaped organs about 4 1/2 inches (11 1/2 centimeters) long lying behind the peritoneum in a mass of fatty tissue, and consist chiefly of nephrons by which urine is secreted, collected, and discharged into a main cavity whence it is conveyed by the ureter to the bladder. 2: Any of various excretory organs of invertebrate animals. BrendaTissueOBO BTO:0000671 kidney BTO:0000677 BrendaTissueOBO BTO:0000677 plant tumor tissue BTO:0000680 A cell of benign or cancerous growth originating from kidney tissue (for example renal cell carcinoma, hypernephroma). BrendaTissueOBO kidney carcinoma cell kidney tumor cell renal cancer cell renal carcinoma cell renal tumor cell BTO:0000680 kidney cancer cell BTO:0000690 BrendaTissueOBO brain tumor cell line BTO:0000690 brain cancer cell line BTO:0000702 Mouse lymphocytic leukemia established from the methylcholanthrene-induced tumor in a DBA strain mouse (subline 212, 8-month-old female) in 1949; the cells were propagated by heterotransplantation into DBA/2 mice; an in-vitro suspension culture was first reported in 1966; cells are used for cytotoxicity studies. BrendaTissueOBO L1210 cell BTO:0000702 L-1210 cell BTO:0000706 The more terminal division of the vertebrate intestine that is wider and shorter than the small intestine, typically divided into cecum, colon, and rectum, and concerned especially with the resorption of water and the formation of feces. BrendaTissueOBO intestinum crassum large bowel BTO:0000706 large intestine BTO:0000707 1: The immature, wingless, and often wormlike feeding form that hatches from the egg of many insects, alters chiefly in size while passing through several molts, and is finally transformed into a pupa or chrysalis from which the adult emerges. 2: The early form of an animal (as a frog or sea urchin) that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. BrendaTissueOBO BTO:0000707 larva BTO:0000709 One of the two cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids; called also prespermatid. BrendaTissueOBO prespermatid BTO:0000709 secondary spermatocyte BTO:0000711 BrendaTissueOBO neuroglioma cell line BTO:0000711 glioma cell line BTO:0000713 A lateral outgrowth from a plant stem that is typically a flattened expanded variably shaped greenish organ, constitutes a unit of the foliage, and functions primarily in food manufacture by photosynthesis. BrendaTissueOBO BTO:0000713 leaf BTO:0000716 BrendaTissueOBO BTO:0000716 pancreatic beta cell line BTO:0000717 1: The conical sac of serous membrane that encloses the heart and the roots of the great blood vessels of vertebrates. 2: A cavity or space that contains the heart of an invertebrate and in arthropods is a part of the hemocoel. BrendaTissueOBO pericardial sac BTO:0000717 pericardium BTO:0000720 BrendaTissueOBO BTO:0000720 plant form BTO:0000722 BrendaTissueOBO BTO:0000722 leg muscle BTO:0000725 A blood cell progenitor or mother cell representing a slightly later stage than the blast cell; it has the capacity for both replication and differentiation, and has pluripotentiality, giving rise to precursors of various different blood cell lines, such as the proerythrocyte and myeloblast, which cannot self-replicate and must differentiate into more mature daughter cells. BrendaTissueOBO CFU-S HSC HSC cell blutbildende Stammzelle colony forming unit spleen hematopoietic precursor cell hematopoietic progenitor cell hemopoietic progenitor cell hemopoietic stem cell progenitor cell BTO:0000725 hematopoietic stem cell BTO:0000729 A cell of a benign or malignant tumor arising especially from the mucosa of the gastrointestinal tract. BrendaTissueOBO BTO:0000729 carcinoid cell BTO:0000731 Lymphocytic leukemia cell that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor, fatigue, appetite loss, bleeding, thrombocytopenia, granulocytopenia, bone and joint pain, and enlargement of the lymph nodes, liver, and spleen, and that occurs chiefly during childhood. BrendaTissueOBO ALL cell acute lymphocytic leukemia cell BTO:0000731 acute lymphoblastic leukemia cell BTO:0000734 A bone-marrow cell: especially: a motile cell with cytoplasmic granules that gives rise to the blood granulocytes and occurs abnormally in the circulating blood (as in myelogenous leukemia). BrendaTissueOBO BTO:0000734 myelocyte BTO:0000735 The individual or generation of a plant exhibiting alternation of generations that bears asexual spores. BrendaTissueOBO BTO:0000735 sporophyte BTO:0000737 BrendaTissueOBO BTO:0000737 leukemia cell line BTO:0000739 Lymphocytic leukemia cell line characterized by an abnormal increase in the number of lymphoblasts. BrendaTissueOBO BTO:0000739 lymphoblastic leukemia cell line BTO:0000740 A cell line of leukemia characterized by proliferation of myeloid tissue (as of the bone marrow and spleen) and an abnormal increase in the number of granulocytes, myelocytes, and myeloblasts in the circulating blood. BrendaTissueOBO granulocytic leukemia cell line myelocytic leukemia cell line myelogenous leukemia cell line BTO:0000740 myeloid leukemia cell line BTO:0000741 BrendaTissueOBO BTO:0000741 lymphocytic leukemia cell line BTO:0000743 BrendaTissueOBO pre-B-cell line BTO:0000743 pre-B-lymphocyte cell line BTO:0000744 Leukemia cell of either of two types marked by an abnormal increase in the number of white blood cells (as lymphocytes) which accumulate in bone marrow, lymphoid tissue (as of the lymph nodes and spleen), and circulating blood. BrendaTissueOBO leukemia cell, lymphocytic lymphatic leukemia cell lymphoid leukemia cell BTO:0000744 lymphocytic leukemia cell BTO:0000746 BrendaTissueOBO proadipocyte cell line BTO:0000746 preadipocyte cell line BTO:0000747 A spore that develops within a sporangium. BrendaTissueOBO BTO:0000747 sporangiospore BTO:0000749 Any of a large class (Sporozoa) of strictly parasitic protozoans that have a complicated life cycle usually involving both asexual and sexual generations often in different hosts and include important pathogens (as malaria parasites and babesias). BrendaTissueOBO sporozoa BTO:0000749 sporozoan form BTO:0000751 Any of the blood cells that are colorless, lack hemoglobin, contain a nucleus, and include the lymphocytes, monocytes, neutrophils, eosinophils, and basophils. BrendaTissueOBO PMN cell PMNC immune cell leucocyte polymorphonuclear cell white blood cell BTO:0000751 leukocyte BTO:0000753 Tissue that is particularly rich in lymphocytes (and accessory cells such as macrophages and reticular cells), particularly the lymph nodes, spleen, thymus, Peyer's patches, pharyngeal tonsils, adenoids, and (in birds) the Bursa of Fabricius. BrendaTissueOBO lymphoid organ lymphoid system BTO:0000753 lymphoid tissue BTO:0000754 Hyaline eosinophilic concentrically-laminated inclusions found in the substantia nigra and locus ceruleus of patients with Parkinsonism and Lewy body dementia. BrendaTissueOBO BTO:0000754 lewy body BTO:0000755 Interstitial cells of the testis, which secrete testosterone. BrendaTissueOBO interstitial cells of Leydig BTO:0000755 Leydig cell BTO:0000756 BrendaTissueOBO BTO:0000756 pituitary gland tumor cell line BTO:0000759 1: A large very vascular glandular organ of vertebrates that secretes bile and causes important changes in many of the substances contained in the blood (as by converting sugars into glycogen which it stores up until required and by forming urea). 2: Any of various large compound glands associated with the digestive tract of invertebrate animals and probably concerned with the secretion of digestive enzymes. BrendaTissueOBO BTO:0000759 liver BTO:0000762 BrendaTissueOBO lung carcinoma cell line BTO:0000762 lung cancer cell line BTO:0000763 One of the usually paired compound saccular thoracic organs that constitute the basic respiratory organ of air-breathing vertebrates. BrendaTissueOBO lung parenchyma parenchyma of lung BTO:0000763 lung BTO:0000764 BrendaTissueOBO BTO:0000764 lung fibroblast BTO:0000765 An externally secreting gland, such as a salivary gland or sweat gland that releases its secretions directly or through a duct. BrendaTissueOBO BTO:0000765 exocrine gland BTO:0000766 BrendaTissueOBO BTO:0000766 blood vessel endothelium BTO:0000771 Neuroglial cells of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together. Originally, the term was used for the astrocytes alone. BrendaTissueOBO macroglial cell BTO:0000771 macroglia BTO:0000772 Often referred to as a blast cell. Unlike other usages of the suffix -blast a lymphoblast is a further differentiation of a lymphocyte, T- or B-, occasioned by an antigenic stimulus. The lymphoblast usually develops by enlargement of a lymphocyte, active re-entry to the S phase of the cell cycle, mitogenesis and production of much m-RNA and ribosomes. BrendaTissueOBO BTO:0000772 lymphoblast BTO:0000773 Human cell line from tissue infected with Epstein-Barr virus, resembling a lymphoblast. BrendaTissueOBO lymphoblastoid cell BTO:0000773 lymphoblastoid cell line BTO:0000774 A cell of any of several diseases of lymph nodes marked by the formation of tumorous masses composed of mature or immature lymphocytes. BrendaTissueOBO BTO:0000774 lymphoblastoma cell BTO:0000775 Any of the colorless weakly motile cells originating from stem cells and differentiating in lymphoid tissue (as of the thymus or bone marrow) that are the typical cellular elements of lymph, include the cellular mediators of immunity, and constitute 20 to 30 percent of the white blood cells of normal human blood. BrendaTissueOBO BTO:0000775 lymphocyte BTO:0000776 Any of the lymphocytes that have antibody molecules on the surface and comprise the antibody-secreting plasma cells when mature. BrendaTissueOBO B cell B lymphocyte B-cell BTO:0000776 B-lymphocyte BTO:0000778 An artery that conveys venous blood from the heart to the lungs. BrendaTissueOBO BTO:0000778 pulmonary artery BTO:0000779 Either of two arteries arising from the aorta and passing between the two layers of the mesentery to the intestine. 1. One that arises just above the bifurcation of the abdominal aorta into the common iliac arteries and supplies the left half of the transverse colon, the descending colon, the sigmoid colon, and most of the rectum - called also inferior mesenteric artery. 2. A large artery that arises from the aorta just below the celiac artery at the level of the first lumbar vertebra and supplies the greater part of the small intestine, the cecum, the ascending colon, and the right half of the transverse colon - called also superior mesenteric artery. BrendaTissueOBO BTO:0000779 mesenteric artery BTO:0000781 The endodermally-derived epithelium of the intestine varies considerably, but the absorptive epithelium of small intestine is usually implied. BrendaTissueOBO BTO:0000781 intestinal epithelium BTO:0000782 Any of several lymphocytes (as a helper T cell) that differentiate in the thymus, possess highly specific cell-surface antigen receptors, and include some that control the initiation or suppression of cell-mediated and humoral immunity (as by the regulation of T and B cell maturation and proliferation) and others that lyse antigen-bearing cells. BrendaTissueOBO T cell T lymphocyte T-cell BTO:0000782 T-lymphocyte BTO:0000783 One of the cells that compose the bulk of the islets of Langerhans and secrete insulin. BrendaTissueOBO beta cell insulin cell insulin-secreting cell islet beta cell pancreatic islet beta cell BTO:0000783 pancreatic beta cell BTO:0000784 Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph. BrendaTissueOBO lymph gland BTO:0000784 lymph node BTO:0000785 A tumor cell of lymphoid tissue. BrendaTissueOBO lymph node cancer cell lymph node carcinoma cell lymphadenoma cell BTO:0000785 lymphoma cell BTO:0000787 BrendaTissueOBO BTO:0000787 gastric cancer cell line BTO:0000790 BrendaTissueOBO pharynx carcinoma cell line BTO:0000790 pharyngeal cancer cell line BTO:0000791 Mouse AKR/J thymic lymphoma cell line. BrendaTissueOBO BW5147 cell BTO:0000791 BW-5147 cell BTO:0000792 BrendaTissueOBO urinary bladder carcinoma cell line BTO:0000792 urinary bladder cancer cell line BTO:0000793 Human neuroblastoma clonal subline of the neuroepithelioma cell line SK-N-SH that had been established in 1970 from the bone marrow biopsy of a 4-year-old girl with metastatic neuroblastoma. BrendaTissueOBO SHSY-5Y cell SK-N-SH-SY5Y cell SK-SH-SY5Y cell SY5Y cell BTO:0000793 SH-SY5Y cell BTO:0000794 BrendaTissueOBO BTO:0000794 pancreatic cancer cell line BTO:0000795 Mouse T cell lymphoma, established from an 8-month-old female DBA/2 mouse with T cell lymphoma in 1985. BrendaTissueOBO L5178Y cell BTO:0000795 L-5178-Y cell BTO:0000797 BrendaTissueOBO colon cancer cell line colon carcinoma cell line colonic carcinoma cell line BTO:0000797 colonic cancer cell line BTO:0000798 Human placenta choriocarcinoma cell line. BrendaTissueOBO BEWO cell BTO:0000798 BeWo cell BTO:0000800 A germ layer lying remote from the surface of the embryo that gives rise to internal tissues such as gut. BrendaTissueOBO hypoblast BTO:0000800 endoderm BTO:0000801 Relatively long-lived phagocytic cell of mammalian tissues, derived from blood monocyte. Macrophages from different sites have distinctly different properties. Main types are peritoneal and alveolar macrophages, tissue macrophages (histiocytes), Kupffer cells of the liver, and osteoclasts. In response to foreign materials may become stimulated or activated. Macrophages play an important role in killing of some bacteria, protozoa, and tumour cells, release substances that stimulate other cells of the immune system, and are involved in antigen presentation. May further differentiate within chronic inflammatory lesions to epithelioid cells or may fuse to form foreign body giant cells or Langhans giant cells. BrendaTissueOBO macrophagocyte monocyte-derived macrophage BTO:0000801 macrophage BTO:0000802 Macrophage found in lung and that can be obtained by lung lavage, responsible for clearance of inhaled particles and lung surfactant. Metabolism slightly different from peritoneal macrophages (more oxidative metabolism), often have multivesicular bodies that may represent residual undigested lung surfactant. BrendaTissueOBO alveolar phagocyte dust cell BTO:0000802 alveolar macrophage BTO:0000803 A type of cell in the pancreatic islets that secretes somatostatin. BrendaTissueOBO BTO:0000803 pancreatic delta cell BTO:0000804 Mouse monocytes-macrophages, established from a tumor in a female BALB/c mouse in 1968; cells were described to synthesize lysozyme and interleukin-1 and to have receptors for immunoglobulin and complement. BrendaTissueOBO J774A.1 cell BTO:0000804 J-774A.1 cell BTO:0000807 BrendaTissueOBO BTO:0000807 chorionic cell line BTO:0000809 BrendaTissueOBO germ cell tumor cell BTO:0000809 germ cell cancer cell BTO:0000810 Any of a group of long blind vessels opening into the posterior part of the alimentary canal in most insects and some other arthropods and functioning primarily as excretory organs. BrendaTissueOBO malphigian tube tuba Malpighii BTO:0000810 malpighian tubule BTO:0000811 BrendaTissueOBO ovarian cancer cell line ovarian carcinoma cell line BTO:0000811 ovary cancer cell line BTO:0000813 Marsupial - potoroo, kidney cell line. BrendaTissueOBO Pt K1 cell BTO:0000813 Pt-K1 cell BTO:0000816 BrendaTissueOBO BTO:0000816 breast cell line BTO:0000817 The specialized accessory gland of the skin of female mammals that secretes milk. In the human female, it is a compound tubuloalveolar gland composed of 15 to 25 lobes arranged radially about the nipple and separated by connective and adipose tissue, each lobe having its own excretory (lactiferous) duct opening on the nipple. The lobes are subdivided into lobules, with the alveolar ducts and alveoli being the secretory portion of the gland. BrendaTissueOBO Brustdruese glandula mammaria lactiferous gland mamma BTO:0000817 mammary gland BTO:0000819 BrendaTissueOBO pharynx cell line BTO:0000819 pharyngeal cell line BTO:0000820 Mouse mammary gland cell line. C127I cells are suitable hosts for transformation with bovine papilloma virus DNA plasmids. BrendaTissueOBO BTO:0000820 C127I cell BTO:0000823 Brownish-gray nerve tissue, especially of the brain and spinal cord, composed of nerve cell bodies and their dendrites and some supportive tissue. BrendaTissueOBO cerebral grey matter gray matter grey matter BTO:0000823 cerebral gray matter BTO:0000827 BrendaTissueOBO BTO:0000827 mantle muscle BTO:0000829 1: A soft highly vascular modified connective tissue that occupies the cavities and cancellous part of most bones. 2: The substance of the spinal cord. BrendaTissueOBO BTO:0000829 marrow BTO:0000830 A large cell that occurs especially in connective tissue and has basophilic granules containing substances (as histamine and heparin) which mediate allergic reactions. BrendaTissueOBO labrocyte mastocyte BTO:0000830 mast cell BTO:0000833 Rat basophilic leukemia (RBL) cell line, obtained by Eccleston et al. and was maintained by serial passage in neonatal Wistar rats. Four cell lines (named RBL I-IV) were started from this tumor between 1973 and 1975. The subline RBL-IV HR+ was derived from RBL-IV, further subcloning established the cell line RBL-2H3. Cells are described to release histamine as an IgE-mediated reaction. BrendaTissueOBO RBL2H3 cell BTO:0000833 RBL-2H3 cell BTO:0000838 A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth. BrendaTissueOBO BTO:0000838 meconium BTO:0000839 Middle of the three germ layers, gives rise to the musculoskeletal, blood, vascular and urinogenital systems, to connective tissue (including that of dermis) and contributes to some glands. BrendaTissueOBO BTO:0000839 mesoderm BTO:0000841 Either of a pair of arteries that arise from the hypogastric arteries of the mammalian fetus and pass through the umbilical cord to the placenta to which they carry the deoxygenated blood from the fetus. BrendaTissueOBO BTO:0000841 umbilical artery BTO:0000842 The female gametophyte produced by a megaspore. BrendaTissueOBO embryo sac female gametophyte BTO:0000842 megagametophyte BTO:0000843 A large cell that has a lobulated nucleus, is found especially in the bone marrow, and is the source of blood platelets. BrendaTissueOBO megacaryocyte megalocaryocyte megalokaryocyte BTO:0000843 megakaryocyte BTO:0000846 BrendaTissueOBO BTO:0000846 erythroleukemia cell line BTO:0000847 An epidermal cell that produces melanin. BrendaTissueOBO BTO:0000847 melanocyte BTO:0000848 A cell of a form of skin cancer that arises in melanocytes, the cells that produce pigment. Melanoma usually begins in a mole. BrendaTissueOBO BTO:0000848 melanoma cell BTO:0000849 BrendaTissueOBO BTO:0000849 melanoma cell line BTO:0000851 BrendaTissueOBO BTO:0000851 adrenal cortex cell line BTO:0000852 A formative plant tissue usually made up of small cells capable of dividing indefinitely and giving rise to similar cells or to cells that differentiate to produce the definitive tissues and organs. BrendaTissueOBO BTO:0000852 meristem BTO:0000853 Cell found within the glomerular lobules of mammalian kidney, where they serve as structural supports, may regulate blood flow, are phagocytic, and may act as accessory cells, presenting antigen in immune responses. BrendaTissueOBO glomerular mesangial cell BTO:0000853 mesangial cell BTO:0000854 Diploid cell resulting from the fusion of male and female gametes at fertilization. BrendaTissueOBO fertilized egg stage BTO:0000854 zygote BTO:0000855 A clear, watery, sometimes faintly yellowish fluid derived from body tissues that contains white blood cells and circulates throughout the lymphatic system, returning to the venous bloodstream through the thoracic duct. Lymph acts to remove bacteria and certain proteins from the tissues, transport fat from the small intestine, and supply mature lymphocytes to the blood. BrendaTissueOBO BTO:0000855 lymph BTO:0000858 The photosynthetic parenchyma between the epidermal layers of a foliage leaf. BrendaTissueOBO BTO:0000858 mesophyll BTO:0000862 A chamber of the heart which receives blood from a corresponding atrium and from which blood is forced into the arteries. BrendaTissueOBO cardiac ventricle BTO:0000862 heart ventricle BTO:0000870 Any of the paired nerves which leave the spinal cord of a craniate vertebrate, supply muscles of the trunk and limbs, and connect with the nerves of the sympathetic nervous system, which arise by a short motor ventral root and a short sensory dorsal root, and of which there are 31 pairs in humans classified according to the part of the spinal cord from which they arise into 8 cervical pairs, 12 thoracic pairs, 5 lumbar pairs, 5 sacral pairs, and one coccygeal pair. BrendaTissueOBO BTO:0000870 spinal nerve BTO:0000871 Mouse, BALB/cd, kidney, adenocarcinoma cell line. Derived from the original Renal-2a BALB/cd renal adenocarcinoma. Cells produce the unique kidney specific esterase ES-2 and have been used in somatic cell hybridisation studies because of their azaguanine resistant properties. BrendaTissueOBO BTO:0000871 RAG cell BTO:0000873 Human T cell leukemia established from the peripheral blood of a 19-year-old man with acute lymphoblastic leukemia (ALL) in relapse in 1971; sister cell line of MOLT-3. BrendaTissueOBO MOLT4 cell BTO:0000873 MOLT-4 cell BTO:0000874 Either of a pair of endocrine glands located in the prothorax of certain insects and regulating molting. BrendaTissueOBO Y-organ prothoracic gland BTO:0000874 molting gland BTO:0000876 A mononuclear phagocytic leukocyte, 13 to 25 mm in diameter, with an ovoid or kidney-shaped nucleus, containing lacy, linear chromatin and abundant gray-blue cytoplasm filled with fine reddish and azurophilic granules. Formed in the bone marrow from promonocytes, monocytes are transported to tissues such as the lung and liver, where they develop into macrophages. BrendaTissueOBO mononuclear leukocyte nongranular leukocyte BTO:0000876 monocyte BTO:0000878 A cell having only one nucleus, especially: MONOCYTE. BrendaTissueOBO BTO:0000878 mononuclear cell BTO:0000879 An internal cavity in each cerebral hemisphere that consists of a central body and three cornua including an anterior one curving forward and outward, a posterior one curving backward, and an inferior one curving downward. BrendaTissueOBO lateral ventricle of brain BTO:0000879 lateral ventricle BTO:0000886 A membrane lining all body passages that communicate with the air, such as the respiratory and alimentary tracts, and having cells and associated glands that secrete mucus. BrendaTissueOBO mucous membrane tunica mucosa BTO:0000886 mucosa BTO:0000887 A body tissue consisting of long cells that contract when stimulated and produce motion. BrendaTissueOBO BTO:0000887 muscle BTO:0000888 An elongated contractile cell that forms the muscles of the body. BrendaTissueOBO muscle cell muscle fiber myocyte BTO:0000888 muscle fibre BTO:0000889 BrendaTissueOBO Burkitt's lymphoma cell line BTO:0000889 Burkitt lymphoma cell line BTO:0000891 Human embryonal carcinoma (teratocarcinoma). NTERA-2 was cloned from cell line TERA-2 which was derived from a metastatic teratocarcinoma of a 22-year-old Caucasian male. BrendaTissueOBO NT-2 cell NT2 cell BTO:0000891 NTERA-2 cell BTO:0000894 A soft white somewhat fatty material that forms a thick myelin sheath about the protoplasmic core of a myelinated nerve fiber. BrendaTissueOBO BTO:0000894 myelin BTO:0000895 The multilamellar myelin membrane is a specialised lipid-rich domain of the glial cell plasma membrane. BrendaTissueOBO BTO:0000895 myelin membrane BTO:0000896 Cluster of electrically coupled neurons in the abdominal ganglion of Aplysia that are homogeneous, easily dissected out and release peptides that stimulate egg laying. BrendaTissueOBO BTO:0000896 bag cell neuron BTO:0000898 A primary tumor cell of the bone marrow. BrendaTissueOBO BTO:0000898 myeloma cell BTO:0000899 BrendaTissueOBO BTO:0000899 myeloma cell line BTO:0000901 The middle and thickest layer of the heart wall, composed of cardiac muscle. BrendaTissueOBO BTO:0000901 myocardium BTO:0000902 One of the tubular conductive vessels in the xylem of vascular plants. Marion 2013-11-07T09:22:23Z BrendaTissueOBO plant trachea plant tracheid trachea tracheid BTO:0000902 plant vessel BTO:0000903 In the heart, the atrium is an upper chamber found on both sides of the heart. The left atrium receives red, oxygenated blood from the lungs by way of the pulmonary veins. The right atrium receives dark red blood from the other parts of the body. BrendaTissueOBO atrial tissue cardiac atrium BTO:0000903 atrium BTO:0000906 BrendaTissueOBO BTO:0000906 myeloid cell line BTO:0000907 The smooth muscle coat of the uterus, which forms the main mass of the organ. BrendaTissueOBO uterine myometrium uterine smooth muscle BTO:0000907 myometrium BTO:0000908 Cell containing glucosinolates (mustard oil glucosides) and myrosinases, enzymes hydrolyzing the glucosinolates. Occur in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae. BrendaTissueOBO BTO:0000908 myrosin cell BTO:0000912 The mucosa, or mucous membrane, is a type of tissue that lines the nasal cavity. Mucous membranes are usually moist tissues that are bathed by secretions such as in the nose. BrendaTissueOBO nasal cavity epithelium BTO:0000912 nasal mucosa BTO:0000913 Focal accumulations of edema fluid in the mucosa of the nose, with hyperplasia of the associated submucosal connective tissue. BrendaTissueOBO BTO:0000913 nasal polyp BTO:0000914 A large granular lymphocyte capable of killing a tumor or microbial cell without prior exposure to the target cell and without having it presented with or marked by a histocompatibility antigen. BrendaTissueOBO NK cell BTO:0000914 natural killer cell BTO:0000916 Human lymphoblastoid cell line. BrendaTissueOBO BTO:0000916 NC37 cell BTO:0000917 A needle-shaped leaf (as of a conifer). BrendaTissueOBO BTO:0000917 needle BTO:0000925 Any of the filamentous bands of nervous tissue that connect parts of the nervous system with the other organs, conduct nervous impulses, and are made up of axons and dendrites together with protective and supportive structures. BrendaTissueOBO BTO:0000925 nerve BTO:0000926 The one of the three major branches or divisions of the trigeminal nerve that supply sensory fibers to the lacrimal gland, eyelids, ciliary muscle, nose, forehead, and adjoining parts. BrendaTissueOBO ophthalmic division BTO:0000926 ophthalmic nerve BTO:0000929 Layer of nerve cells in the retina, embryologically part of the brain. The incoming light passes through nerve-fibres and intermediary nerve cells of the neural retina, before encountering the light-sensitive rods and cones at the interface between neural retina and the pigmented retinal epithelium. BrendaTissueOBO BTO:0000929 neural retina BTO:0000930 Any embryonic cell which develops into a nerve cell or neuron; an immature nerve cell. BrendaTissueOBO BTO:0000930 neuroblast BTO:0000931 Malignant tumour cell derived from primitive ganglion cells. Mainly a tumour of childhood. Commonest sites are adrenal medulla and retroperitoneal tissue. The cells may partially differentiate into cells having the appearance of immature neurons. BrendaTissueOBO NBL cell BTO:0000931 neuroblastoma cell BTO:0000932 BrendaTissueOBO NBL cell line BTO:0000932 neuroblastoma cell line BTO:0000933 Mouse neuroblastoma 6-thioguanine resistant mutant of cell line N18 that was established from a mouse of strain A/Jax with neuroblastoma C1300; cells were described to form cAMP in response to prostaglandin E1 and to be aneuploid (modal chromosome number of 81). BrendaTissueOBO BTO:0000933 N18TG2 cell BTO:0000934 Human neuroblastoma, established from an abdominal mass (diagnosed as neuroblastoma) of a 1-year-old caucasian boy in 1967. BrendaTissueOBO BTO:0000934 IMR-32 cell BTO:0000935 Human neuroblastoma cell line. BrendaTissueOBO LAN5 cell BTO:0000935 LAN-5 cell BTO:0000936 Intracellular knot or clump of neurofibrils seen in the cerebral cortex in Alzheimer's disease. BrendaTissueOBO neurofilament tangle BTO:0000936 neurofibrillary tangle BTO:0000938 A grayish or reddish granular cell with specialized processes that is the fundamental functional unit of nervous tissue. BrendaTissueOBO nerve cell neuronal cell BTO:0000938 neuron BTO:0000939 One of the innermost cells of the deeper epidermis of the skin. BrendaTissueOBO BTO:0000939 basal cell BTO:0000942 Neuroblastoma glioma hybrid cell line. BrendaTissueOBO NG 108-15 cell NG108-15 cell BTO:0000942 NG-108-15 cell BTO:0000944 Very widely used mouse fibroblast cell line; 3T3 cells have been derived from different mouse strains and it is therefore important to define the particular cell line. NIH strain were from the National Institute of Health in the USA; Mouse embryonic fibroblast cell line, established from disaggregated Swiss albino mouse embryos in 1962. BrendaTissueOBO 3T3 cell 3T3 fibroblast 3T3-Swiss albino cell NIH 3T3 cell NIH/3T3 cell NIH3T3 cell BTO:0000944 NIH-3T3 cell BTO:0000946 Testis; metastatic site: lung malignant pluripotent embryonal carcinoma cell line. The NTERA-2 cl.D1 cell line is a pluripotent human testicular embryonal carcinoma cell line derived by cloning the NTERA-2 cell line. BrendaTissueOBO NTERA-2 cl.D1 cell BTO:0000946 NT2/D1 cell BTO:0000947 BrendaTissueOBO BTO:0000947 neuronal cell line BTO:0000948 Human ovary; metastatic site: ascites adenocarcinoma cell line; established from a 64-year-old caucasian female. BrendaTissueOBO SK-OV-3 cell SKOV3 cell BTO:0000948 SKOV-3 cell BTO:0000950 Novikoff hepatoma has been induced by feeding 4-dimethylaminoazobenzene to a male rat. BrendaTissueOBO BTO:0000950 Novikoff hepatoma cell BTO:0000954 Any of various immature insects; especially: a larva of an insect (as a grasshopper, true bug, or mayfly) with incomplete metamorphosis that differs from the imago especially in size and in its incompletely developed wings and genitalia. BrendaTissueOBO BTO:0000954 nymph BTO:0000956 BrendaTissueOBO BTO:0000956 gut epithelium BTO:0000957 The back of the neck. BrendaTissueOBO BTO:0000957 nape BTO:0000958 An undifferentiated germ cell of a male, originating in a seminiferous tubule and dividing into two primary spermatocytes. BrendaTissueOBO spermatophore spermatospore spermospore BTO:0000958 spermatogonium BTO:0000959 A muscular tube that in humans is about nine inches (23 centimeters) long and passes from the pharynx down the neck between the trachea and the spinal column and behind the left bronchus where it pierces the diaphragm slightly to the left of the middle line and joins the cardiac end of the stomach. BrendaTissueOBO gullet oesophagus BTO:0000959 esophagus BTO:0000961 A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes). BrendaTissueOBO bulbus olfactorius BTO:0000961 olfactory bulb BTO:0000964 The immature reproductive cell prior to fertilization; it is derived from an oogonium, and is called a primary oocyte prior to completion of the first maturation division, and a secondary oocyte between the first and second maturation division. BrendaTissueOBO BTO:0000964 oocyte BTO:0000966 The optic nerve is the nerve that connects the eye to the brain and carries the impulses formed by the retina to the visual cortex of the brain. BrendaTissueOBO BTO:0000966 optic nerve BTO:0000968 A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities. BrendaTissueOBO BTO:0000968 osteoclast BTO:0000970 A cell of a sarcoma derived from bone or containing bone tissue. BrendaTissueOBO osteoblastic sarcoma cell osteogenic sarcoma cell BTO:0000970 osteosarcoma cell BTO:0000971 Human osteogenic sarcoma, established from the primary osteogenic sarcoma of an 11-year-old Caucasian woman in 1973. BrendaTissueOBO SAOS2 cell BTO:0000971 SAOS-2 cell BTO:0000973 The mucous membrane lining the respiratory tract. BrendaTissueOBO BTO:0000973 respiratory mucosa BTO:0000975 One of the typically paired essential female reproductive organs that produce eggs and in vertebrates female sex hormones. BrendaTissueOBO BTO:0000975 ovary BTO:0000977 BrendaTissueOBO BTO:0000977 ovary cell line BTO:0000980 Either of a pair of slender ducts through which ova pass from the ovaries to the uterus in the female reproductive system of humans and higher mammals. BrendaTissueOBO fallopian tube salpinx tuba uterina tuba uterinae uterine tube BTO:0000980 oviduct BTO:0000981 A hermaphrodite gonad (as in some scale insects). BrendaTissueOBO BTO:0000981 ovotestis BTO:0000988 A large lobulated gland of vertebrates that secretes digestive enzymes and the hormones insulin and glucagon. BrendaTissueOBO BTO:0000988 pancreas BTO:0000989 An end organ mediating the sensation of taste and lying chiefly in the epithelium of the tongue. BrendaTissueOBO BTO:0000989 taste bud BTO:0000991 Irregular microscopic structures scattered throughout the pancreas and comprising its endocrine part (the endocrine pancreas). In humans, they are composed of at least four types of cells: the alpha cells, which secrete glucagon; the beta cells, which are the most abundant and secrete insulin; the delta cells, which secrete somatostatin; and the PP cells, which secrete pancreatic polypeptide. Degeneration of the beta cells, whose secretion (insulin) is important in carbohydrate metabolism, is the major cause of type I diabetes mellitus. BrendaTissueOBO island of Langerhans island of pancreas islet of Langerhans BTO:0000991 pancreatic islet BTO:0000994 Rat basophilic leukemia; this rat basophilic leukemia (RBL) cell line was established from chlorethylamine-treated rats. BrendaTissueOBO BTO:0000994 RBL-1 cell BTO:0000996 A cell from which gametes develop by meiotic division, especially a spermatocyte or an oocyte. BrendaTissueOBO BTO:0000996 gametocyte BTO:0000997 Any of usually four small endocrine glands that are adjacent to or embedded in the thyroid gland and produce parathyroid hormone. BrendaTissueOBO parathyroid BTO:0000997 parathyroid gland BTO:0001001 The upper central lobe of the cerebral hemisphere, separated from the temporal lobe below by the lateral sulcus, but continuous at the posterior end of that sulcus, and separated from the frontal lobe by the central sulcus. Behind, it is continuous with the occipital lobe on the lateral surface, but separated from it by the parietooccipital sulcus on the medial surface. BrendaTissueOBO parietal cortex BTO:0001001 parietal lobe BTO:0001005 Marion 2010-01-28T05:56:47Z BrendaTissueOBO BTO:0001005 amnion epithelial cell BTO:0001006 The inferior portion of the trunk of the body, bounded anteriorly and laterally by the two hip bones and posteriorly by the sacrum and coccyx. The pelvis is divided by a plane passing through the terminal lines into the pelvis major superiorly and the pelvis minor inferiorly. BrendaTissueOBO BTO:0001006 pelvis BTO:0001008 BrendaTissueOBO peripheral blood mononuclear cell cell line BTO:0001008 PBMC cell line BTO:0001009 Rat adrenal pheochromocytoma established from a transplantable rat adrenal pheochromocytoma in 1976; cells were described to synthesize catecholamines (dopamine, norepinephrine); in response to nerve growth factor (NGF) a neuronal phenotype could be induced reversibly. BrendaTissueOBO PC12 cell pheochromocytoma 12 cell BTO:0001009 PC-12 cell BTO:0001011 Large neurons in the cerebellar cortex that have piriform cell bodies in the Purkinje layer (the stratum purkinjense cerebelli) and large branching dendrite trees going through the outer (molecular) layer towards the surface. BrendaTissueOBO Purkinje cell Purkinje neuron BTO:0001011 cerebellar Purkinje cell BTO:0001018 BrendaTissueOBO BTO:0001018 basophilic leukemia cell line BTO:0001019 BrendaTissueOBO prostate cell line BTO:0001019 prostate gland cell line BTO:0001020 The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket. BrendaTissueOBO alveolar periosteum alveolodental ligament alveolodental membrane desmodontium odontoperiosteum paradentium peridental membrane peridontal membrane peridontium BTO:0001020 periodontal ligament BTO:0001022 The dense fibrous membrane covering the surface of bones except at the joints and serving as an attachment for muscles and tendons. BrendaTissueOBO BTO:0001022 periosteum BTO:0001023 A malignant tumor cell of the ovary. BrendaTissueOBO ovarian cancer cell ovarian carcinoma cell ovary carcinoma cell BTO:0001023 ovary cancer cell BTO:0001025 A mixture of monocytes and lymphocytes; blood leucocytes from which granulocytes have been separated and removed. BrendaTissueOBO PBM cell PBMC PBMC cell BTO:0001025 peripheral blood mononuclear cell BTO:0001027 The peripheral nerves include the 12 cranial nerves, the spinal nerves and roots, and what are called the autonomic nerves that are concerned specifically with the regulation of the heart muscle, the muscles in blood vessel walls, and glands. BrendaTissueOBO BTO:0001027 peripheral nerve BTO:0001028 The peripheral nervous system (PNS) connects the central nervous system (CNS) to sensory organs (such as the eye and ear), other organs of the body, muscles, blood vessels and glands. BrendaTissueOBO PNS BTO:0001028 peripheral nervous system BTO:0001033 BrendaTissueOBO CaP cell CaP cell line PCa cell PCa cell line prostate carcinoma cell line prostate gland cancer cell line prostate tumor cell line BTO:0001033 prostate cancer cell line BTO:0001035 BrendaTissueOBO BTO:0001035 hematopoietic cell line BTO:0001036 The other light-sensitive cell type of the retina, that, unlike retinal rods, is differentially sensitive to particular wavelengths of light, and is important for colour vision. There are three types of cones, each type sensitive to red, green or blue. Present in large numbers in the fovea. BrendaTissueOBO cone cell BTO:0001036 retinal cone BTO:0001037 1: A peripheral nerve cell, as an olfactory cell, located at a sensory receiving surface and being the primary receptor of a sensory impulse. 2: A nerve cell, as a spinal ganglion cell, transmitting sensory impulses. BrendaTissueOBO sensory neuron BTO:0001037 sensory cell BTO:0001039 Seminiferous tubules are made up of Sertoli cells and germ cells and they are surrounded by peritubular and myoid cells. BrendaTissueOBO BTO:0001039 peritubular cell BTO:0001042 The one of the four basal ganglia in each cerebral hemisphere that is part of the limbic system and consists of an almond-shaped mass of gray matter in the anterior extremity of the temporal lobe. BrendaTissueOBO amygdaloid body amygdaloid complex amygdaloid nuclear complex amygdaloid nuclear group amygdaloid nucleus archistriatum corpus amygdaloideum nucleus amygdalae BTO:0001042 amygdala BTO:0001043 Fully developed and mature: GROWN-UP. BrendaTissueOBO adult stage BTO:0001043 adult BTO:0001044 A cell, as a white blood cell, that engulfs and consumes foreign material, as microorganisms, and debris. BrendaTissueOBO BTO:0001044 phagocyte BTO:0001045 BrendaTissueOBO T-cell line BTO:0001045 T-lymphocyte cell line BTO:0001049 The part of the vertebrate alimentary canal between the cavity of the mouth and the esophagus. The pharynx of Nematodes is an efficient pump and forces food into the intestines. BrendaTissueOBO BTO:0001049 pharynx BTO:0001054 Pheochromocytoma is a rare tumor that arises from tissue in the adrenal gland. The tumor increases production of adrenaline and noradrenaline, which raises blood pressure and heart rate. BrendaTissueOBO BTO:0001054 pheochromocytoma cell BTO:0001056 A malignant neoplasm of blood-forming tissues; marked by proliferation of myelocytes and their presence in the blood. BrendaTissueOBO granulocytic leukemia cell myelocytic leukemia cell BTO:0001056 myeloid leukemia cell BTO:0001057 A dorsal tubular structure in the vertebrate embryo formed by longitudinal folding of the neural plate and differentiating into the brain and spinal cord. BrendaTissueOBO BTO:0001057 neural tube BTO:0001058 A complex tissue in the vascular system of higher plants that consists mainly of sieve tubes and elongated parenchyma cells usually with fibers and that functions in translocation and in support and storage. BrendaTissueOBO BTO:0001058 phloem BTO:0001060 A specialized cell type in a multicellular organism that is sensitive to light. This definition excludes single-celled organisms, but includes non-eye receptors, such as snake infra-red detectors or photosensitive pineal gland cells. BrendaTissueOBO photoreceptor cell BTO:0001060 photoreceptor BTO:0001061 Human prostate carcinoma cell line; established from the bone marrow metastasis isolated post-mortem from a 62-year-old Caucasian man with grade IV prostate cancer, poorly differentiated adenocarcinoma, after androgen suppression therapy; described to form tumors in nude mice, to grow in soft agar, and to be unresponsive to androgen treatment. BrendaTissueOBO PC3 cell BTO:0001061 PC-3 cell BTO:0001063 A general motor and sensory nerve on each side of the body that arises chiefly from the fourth cervical nerve, passes down through the thorax to the diaphragm, and supplies or gives off branches supplying especially the pericardium, pleura, and diaphragm. BrendaTissueOBO diaphragmatic nerve nervus phrenicus phrenic BTO:0001063 phrenic nerve BTO:0001065 Human prostate epithelial carcinoma cell line. BrendaTissueOBO BTO:0001065 Tsu-Pr1 cell BTO:0001067 A small, cone-shaped organ in the brain of most vertebrates that secretes the hormone melatonin. BrendaTissueOBO epiphysis cerebri pineal body pineal organ BTO:0001067 pineal gland BTO:0001072 Either of the fifth pair of cranial nerves, having sensory and motor functions in the face, teeth, mouth, and nasal cavity. BrendaTissueOBO cranial nerve V fifth cranial nerve nervus trigeminus trigeminus BTO:0001072 trigeminal nerve BTO:0001073 A small oval endocrine organ that is attached to the infundibulum of the brain, consists of an epithelial anterior lobe joined by an intermediate part to a posterior lobe of nervous origin, and produces various internal secretions directly or indirectly impinging on most basic body functions. BrendaTissueOBO glandula pituitaria hypophysis cerebri pituitary pituitary body pituitary gland BTO:0001073 hypophysis BTO:0001076 A benign tumor of the pituitary, the master gland that controls other glands and influences numerous body functions including growth. Although the tumor itself is not cancerous, it may affect pituitary function, and therefore may need to be removed. BrendaTissueOBO pituitary adenoma cell pituitary tumor cell BTO:0001076 pituitary gland tumor cell BTO:0001077 Mouse pituitary tumor cell line. Morphology: small rounded cells. BrendaTissueOBO AtT 20 cell AtT20 cell BTO:0001077 AtT-20 cell BTO:0001078 The vascular organ in mammals except monotremes and marsupials that unites the fetus to the maternal uterus and mediates its metabolic exchanges through a more or less intimate association of uterine mucosal with chorionic and usually allantoic tissues; also: an analogous organ in another animal. BrendaTissueOBO BTO:0001078 placenta BTO:0001079 A thin layer of ectoderm that forms the wall of many mammalian blastulas and functions in the nutrition and implantation of the embryo. BrendaTissueOBO trophoderm BTO:0001079 trophoblast BTO:0001085 The vessels of the body, especially the blood vessels. BrendaTissueOBO Gefaesssystem BTO:0001085 vascular system BTO:0001086 Totipotent cell cultured from early embryo. Have the advantage that following modification in vitrothey can be used to produce chimeric embryos and thus transgenic animals. BrendaTissueOBO ES cell BTO:0001086 embryonic stem cell BTO:0001088 BrendaTissueOBO BTO:0001088 gastric cell line BTO:0001090 The natural opening through which food passes into the body of an animal and which in vertebrates is typically bounded externally by the lips and internally by the pharynx and encloses the tongue, gums, and teeth. BrendaTissueOBO buccal cavity cavitas oris cavum oris mouth cavity oral cavity oral fissure oral vestibule rima oris vestibule of mouth vestibulum oris BTO:0001090 mouth BTO:0001092 Human stomach carcinoma cell line, established from a 55 years old mongoloid male. BrendaTissueOBO KATO III cell BTO:0001092 KATO-III cell BTO:0001093 Mouse, BALB/cxNZB F1, lymphoblastic lymphoma cell line. Morphology: Lymphoblast Mouse B cell lymphoma. BrendaTissueOBO BTO:0001093 WEHI-231 cell BTO:0001096 Any of the cells responsible for the production of immunity mediated by cells or antibodies and including lymphocytes, lymphoblasts, and plasma cells. Cells derived from stem cells of the lymphoid lineage: large and small lymphocytes, plasma cells. BrendaTissueOBO BTO:0001096 lymphoid cell BTO:0001097 The structure into which a haploid microspore develops; contains a halpoid tube nucleus and two haploid sperm nuclei at maturity. BrendaTissueOBO male generative cell pollen grain BTO:0001097 pollen BTO:0001099 The modified blastula of a placental mammal. BrendaTissueOBO BTO:0001099 blastocyst BTO:0001101 A broad mass of chiefly transverse nerve fibers conspicuous on the ventral surface of the brain of man and lower mammals at the anterior end of the medulla oblongata. BrendaTissueOBO BTO:0001101 pons BTO:0001102 Any of the vessels through which blood circulates in the body. BrendaTissueOBO BTO:0001102 blood vessel BTO:0001103 A usually voluntary muscle made up of elongated, multinucleated, transversely striated muscle fibers, having principally bony attachments. BrendaTissueOBO skeletal muscle system somatic muscle striated muscle BTO:0001103 skeletal muscle BTO:0001104 Any of several nerves that arise in pairs from the brainstem and reach the periphery through openings in the skull. There are 12 such pairs in mammals, birds, and reptiles and usually 10 pairs in amphibians and fish. BrendaTissueOBO BTO:0001104 cranial nerve BTO:0001106 A type of acute lymphoblastic leukaemia, ALL, a cancer of the lymphocyte-forming cells called lymphoblasts. BrendaTissueOBO T-ALL cell T-cell leukemia cell acute T-lymphocytic leukemia cell acute lymphoblastic leukemia cell, T-cell type BTO:0001106 T-cell acute lymphoblastic leukemia cell BTO:0001110 1: An inactive stage just before the pupa in the development of certain insects. 2:The form of an insect in this stage. BrendaTissueOBO BTO:0001110 prepupa BTO:0001111 Any of the small glands at the base of the glans penis that secrete smegma. BrendaTissueOBO gland of Tyson BTO:0001111 preputial gland BTO:0001113 A fold of skin that covers the glans of the penis. BrendaTissueOBO foreskin BTO:0001113 prepuce BTO:0001116 Immediately next to the growing inflorescence tip is the floral primordium, which is a bump of cells representing the very youngest stage of a flower. BrendaTissueOBO BTO:0001116 floral primordium BTO:0001119 The part of the primary meristem of a plant that forms cambium and primary vascular tissues. BrendaTissueOBO BTO:0001119 procambium BTO:0001120 BrendaTissueOBO BTO:0001120 epithelial cell line BTO:0001122 African trypanosomes have a digenetic life cycle, which includes growth in the bloodstream and tissue spaces of a mammalian host and several distinct developmental stages, including the procyclic form, in an insect host, Glossina spp., tsetse fly. BrendaTissueOBO BTO:0001122 procyclic form BTO:0001123 BrendaTissueOBO BTO:0001123 peripheral ganglion BTO:0001124 Any of the bodies representing the morphological leptomonad stage in the life cycle of certain trypanosomatid protozoa resembling the typical adult form of members of the genus Leptomonas, in which the elongate or pear-shaped cell has a central nucleus and at the anterior end a kinetoplast and a basal body from which arises a single long, slender flagellum. BrendaTissueOBO BTO:0001124 promastigote BTO:0001129 A firm partly muscular partly glandular body that is situated about the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. BrendaTissueOBO prostate BTO:0001129 prostate gland BTO:0001130 A malignant tumour cell of glandular origin in the prostate. Over 95% are adenocarcinomas. BrendaTissueOBO prostate cancer cell prostate carcinoma cell prostate tumor cell prostate tumour cell BTO:0001130 prostate gland cancer cell BTO:0001131 Baby hamster kidney cell line. BrendaTissueOBO BTO:0001131 BHK cell BTO:0001134 The primary usually filamentous thalloid stage of the gametophyte in mosses and in some liverworts comparable to the prothallium in ferns. BrendaTissueOBO BTO:0001134 protonema BTO:0001136 1: The glandular or true stomach of a bird that is situated between the crop and gizzard. 2: A muscular dilatation of the foregut in most mandibulate insects that is armed internally with chitinous teeth or plates for triturating food. 3: The thin-walled sac in front of the gizzard of an earthworm. BrendaTissueOBO BTO:0001136 proventriculus BTO:0001138 An organized embryonic structure morphologically similar to a zygotic embryo but initiated from somatic non-zygotic cells. Under in vitro conditions, somatic embryos go through developmental processes similar to embryos of zygotic origin. BrendaTissueOBO somatic embryoid BTO:0001138 somatic embryo BTO:0001142 The soft, succulent part of a fruit usually composed of mesocarp. BrendaTissueOBO fruit pulp BTO:0001142 pulp BTO:0001143 An intermediate usually quiescent stage of a metamorphic insect as a bee, moth, or beetle that occurs between the larva and the imago, is usually enclosed in a cocoon or protective covering, and undergoes internal changes by which larval structures are replaced by those typical of the imago. BrendaTissueOBO BTO:0001143 pupa BTO:0001152 The lower part of the axis of a plant embryo or seedling. BrendaTissueOBO BTO:0001152 radicle BTO:0001156 The point on a stem at which leaves and buds are attached. BrendaTissueOBO stem node BTO:0001156 node BTO:0001157 An evagination of the terminal portion of the intestine of Elasmobranchii. Function formerly thought to be related to digestion or excretion, but now considered to secrete high concentrations of excess sodium chloride. Found also in the coelacanth Latimeria chalumnae. BrendaTissueOBO BTO:0001157 rectal gland BTO:0001158 The terminal part of the intestine from the sigmoid flexure to the anus. BrendaTissueOBO intestinum rectum BTO:0001158 rectum BTO:0001160 Marrow of developing bone, of the ribs, vertebrae, and many of the smaller bones; it is the site of production of erythrocytes and granular leukocytes. BrendaTissueOBO medulla ossium rubra red marrow BTO:0001160 red bone marrow BTO:0001164 The earliest cytologically identifiable precursor in the thrombocytic series, a large cell that matures to form a promegakaryocyte. BrendaTissueOBO megacaryoblast BTO:0001164 megakaryoblast BTO:0001165 A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters. BrendaTissueOBO BTO:0001165 renal artery BTO:0001166 Cortex of kidney. BrendaTissueOBO kidney cortex BTO:0001166 renal cortex BTO:0001168 1: The inner lining of the fourth stomach of calves and other young ruminants. 2: A dried extract made from the stomach lining of a ruminant, used in cheesemaking to curdle milk. BrendaTissueOBO BTO:0001168 rennet BTO:0001169 Preadipocyte cell line. BrendaTissueOBO 3T3-442A cell F442A cell BTO:0001169 3T3-F442A cell BTO:0001170 A cell that is not actively in the process of dividing. BrendaTissueOBO BTO:0001170 resting cell BTO:0001173 An immature red blood cell that appears especially during regeneration of lost blood and has a fine basophilic reticulum formed of ribosomal remains. BrendaTissueOBO BTO:0001173 reticulocyte BTO:0001175 The sensory membrane that lines the eye, is composed of several layers including one containing the rods and cones, and functions as the immediate instrument of vision by receiving the image formed by the lens and converting it into chemical and nervous signals which reach the brain by way of the optic nerve. BrendaTissueOBO Netzhaut BTO:0001175 retina BTO:0001176 The main type of cell found in the inside lining of blood vessels, lymph vessels, and the heart. BrendaTissueOBO BTO:0001176 endothelial cell BTO:0001177 The pigment cell layer that nourishes the retinal cells, located just outside the retina and attached to the choroid. BrendaTissueOBO epithelium, retinal pigment BTO:0001177 retinal pigment epithelium BTO:0001178 A malignant congenital blastoma, occurring in both hereditary and sporadic forms, composed of tumor cells arising from the retinoblasts, appearing in one or both eyes in children under 5 years of age, and usually diagnosed initially by a bright white or yellow pupillary reflex -leukokoria. BrendaTissueOBO glioma retinae cell BTO:0001178 retinoblastoma cell BTO:0001180 A plant cell committed to develop into a cell type that differs from the surrounding tissue. BrendaTissueOBO BTO:0001180 idioblast BTO:0001181 A somewhat elongate usually horizontal subterranean plant stem that is often thickened by deposits of reserve food material, produces shoots above and roots below, and is distinguished from a true root in possessing buds, nodes, and usually scalelike leaves. BrendaTissueOBO BTO:0001181 rhizome BTO:0001182 The main root of a plant is called the primary root; others are called secondary roots. BrendaTissueOBO tap root taproot BTO:0001182 primary root BTO:0001188 The usually underground part of a seed plant body that originates usually from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support, and differs from a stem especially in lacking nodes, buds, and leaves. BrendaTissueOBO BTO:0001188 root BTO:0001190 Gall-like structures on the roots of legumes that contain symbiotic nitrogen-fixing bacteria. BrendaTissueOBO nodule root tubercle BTO:0001190 root nodule BTO:0001191 The root tip is the tip of the root and contains the root cap and the apical meristem -the actively growing region. BrendaTissueOBO BTO:0001191 root tip BTO:0001193 Murine mammary tumor line from a female mus musculus. BrendaTissueOBO C127cell BTO:0001193 C-127 cell BTO:0001194 The large first compartment of the stomach of a ruminant in which cellulose is broken down by the action of symbiotic microorganisms. BrendaTissueOBO paunch BTO:0001194 rumen BTO:0001196 Insect - fall armyworm, Spodoptera frugiperda, cell line. This cell line was derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae (species Spodoptera frugiperda, family Sciaridae, order Lepidoptera); cells are susceptible to Baculovirus infection. BrendaTissueOBO IPLB-SF-21-AE cell Sf21 cell Sf21AE cell BTO:0001196 SF-21 cell BTO:0001200 BrendaTissueOBO BTO:0001200 aorta thoracica smooth muscle cell line BTO:0001201 A cluster of leaves in crowded circles or spirals arising basally from a crown, as in the dandelion, or apically from an axis with greatly shortened internodes, as in many tropical palms. BrendaTissueOBO BTO:0001201 rosette BTO:0001202 A slightly alkaline secretion of water, mucin, protein, salts, and often a starch-splitting enzyme, as ptyalin, that is secreted into the mouth by salivary glands, lubricates ingested food, and often begins the breakdown of starches. BrendaTissueOBO BTO:0001202 saliva BTO:0001203 The glands of the oral cavity whose combined secretion constitutes the saliva. BrendaTissueOBO BTO:0001203 salivary gland BTO:0001207 A malignant neoplasm cell arising in tissue of mesodermal origin, as connective tissue, bone, cartilage, or striated muscle. BrendaTissueOBO BTO:0001207 sarcoma cell BTO:0001208 The modified upper part of the trachea of air-breathing vertebrates that in humans, most other mammals, and a few lower forms contains the vocal cords. BrendaTissueOBO Kehlkopf BTO:0001208 larynx BTO:0001209 BrendaTissueOBO BTO:0001209 umbilical cord cell line BTO:0001211 XPMUser 2011-02-23T09:07:03Z BrendaTissueOBO BTO:0001211 breast epithelial cell BTO:0001214 BrendaTissueOBO BTO:0001214 Yoshida sarcoma cell BTO:0001218 Either of a pair of large triangular bones lying one in each dorsal lateral scapula: part of the thorax, being the principal bone of the corresponding half of the shoulder girdle, and articulating with the corresponding clavicle or coracoid. BrendaTissueOBO scapula bone shoulder blade BTO:0001218 scapula BTO:0001220 Named after the German physiologist Theodor Schwann. Schwann cells are a variety of glial cell that keep peripheral nerve fibres (both myelinated and unmyelinated) alive. BrendaTissueOBO neurolemmocyte BTO:0001220 Schwann cell BTO:0001221 The largest nerve of the body: origin, sacral plexus-L4-S3; it leaves the pelvis through the greater sciatic foramen; branches, divides into the tibial and common peroneal nerves, usually in lower third of thigh; distribution-see individual branches, in this table; modality, general sensory and motor. BrendaTissueOBO nervus ischiadicus nervus sciaticus BTO:0001221 sciatic nerve BTO:0001225 Human gastric adenocarcinoma, established from the poorly differentiated adenocarcinoma of the stomach (medullary type) of a 62-year-old woman. BrendaTissueOBO MKN45 cell BTO:0001225 MKN-45 cell BTO:0001228 The embryonic product of the germination of a seed. The young shoot and root axis. BrendaTissueOBO BTO:0001228 seedling BTO:0001229 Normal lung fibroblast cell line from a human female. The human diploid fibroblast strain IMR-90 was derived by W.W. Nichols and associates from the lungs of a 16-week female fetus. BrendaTissueOBO BTO:0001229 IMR-90 cell BTO:0001230 A viscid whitish fluid of the male reproductive tract consisting of spermatozoa suspended in secretions of accessory glands. BrendaTissueOBO seminal fluid sperm BTO:0001230 semen BTO:0001231 A ganglion on the sensory root of the fifth cranial nerve, situated in a cleft within the dura mater (trigeminal cave) on the anterior surface of the petrous portion of the temporal bone, and giving off the ophthalmic and maxillary and part of the mandibular nerve; it contains the cells of origin of most of the sensory fibers of the trigeminal nerve. BrendaTissueOBO Gasser's ganglion ganglion of trigeminal nerve ganglion trigeminale gasserian ganglion semilunar ganglion BTO:0001231 trigeminal ganglion BTO:0001232 The fluid portion of the semen, in which the spermatozoa are suspended. BrendaTissueOBO prostate fluid prostatic fluid seminal fluid BTO:0001232 seminal plasma BTO:0001233 The early developmental stage that, through embryological development, ultimately becomes an adult individual. In plants, that portion of a seed that will form the growing seedling following germination, it has a radicle, apical meristem, and embryonic leaf or leaves. BrendaTissueOBO embryo plant germ BTO:0001233 plant embryo BTO:0001234 Either of a pair of glandular pouches that lie one on either side of the male reproductive tract and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct. BrendaTissueOBO glandula seminalis glandula vesiculosa seminal gland vesicula seminalis BTO:0001234 seminal vesicle BTO:0001235 One of two or three twisted, curved tubules in each lobule of the testis in which spermatozoa develop. BrendaTissueOBO BTO:0001235 seminiferous tubule BTO:0001238 Any of the elongated, striated cells of the seminiferous tubules of the testis, to which spermatids attach for nourishment during spermatogenesis. BrendaTissueOBO BTO:0001238 Sertoli cell BTO:0001240 Insect - fall armyworm (Spodoptera frugiperda) cell line, cloned from the parent cell line, IPLB-SF-21-AE, derived from pupal ovarian tissue of the fall armyworm (species Spodoptera frugiperda, family Sciaridae, order Lepidoptera); cells are susceptible to infection with MNPV and other Baculoviruses; cells can be used with Baculovirus expression vectors. It was derived from SF-21. BrendaTissueOBO Sf9 cell BTO:0001240 SF-9 cell BTO:0001242 BrendaTissueOBO BTO:0001242 fetal cell line BTO:0001243 A sending out of new growth or the growth sent out: as a stem or branch with its leaves and appendages especially when not yet mature. BrendaTissueOBO BTO:0001243 shoot BTO:0001244 The organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra. BrendaTissueOBO BTO:0001244 urinary tract BTO:0001247 Found in phloem tissue, sieve tubes lack a nucleus, and are thought to be responsible for the translocation of material across the phloem tissue. BrendaTissueOBO BTO:0001247 sieve tube BTO:0001248 Human ductal breast carcinoma ductal cell line. Morphology: epithelial-likeSpecies: human female 54 years old; Tissue: breast; Tumor: carcinoma, ductal; Derived from: T47, originally derived from pleural effusion. BrendaTissueOBO T47-D cell T47D cell BTO:0001248 T-47D cell BTO:0001249 A narrow elongated two-valved usually many-seeded capsule that is characteristic of the mustard family, opens by sutures at either margin, and has two parietal placentas. BrendaTissueOBO BTO:0001249 silique BTO:0001252 The shin bone: the inner and larger bone of the leg below the knee; it articulates with the femur and head of the fibula above and with the talus below. BrendaTissueOBO BTO:0001252 tibia BTO:0001253 The integument of an animal (as a fur-bearing mammal or a bird) separated from the body usually with its hair or feathers. BrendaTissueOBO BTO:0001253 skin BTO:0001254 The fluid excreted from the sweat glands of the skin. BrendaTissueOBO skin exudate BTO:0001254 sweat BTO:0001255 BrendaTissueOBO BTO:0001255 skin fibroblast BTO:0001257 A muscle that when contracted acts to bend a joint or limb in the body. BrendaTissueOBO BTO:0001257 flexor BTO:0001260 Muscle tissue that lacks cross striations, that is made up of elongated spindle-shaped cells having a central nucleus, and that is found in vertebrate visceral structures (as the stomach and bladder) as thin sheets performing functions not subject to conscious control by the mind and in all or most of the musculature of invertebrates other than arthropods. BrendaTissueOBO BTO:0001260 smooth muscle BTO:0001262 BrendaTissueOBO Weichteil BTO:0001262 soft body part BTO:0001264 A ganglion on the dorsal root of each spinal nerve that is one of a series of ganglia lodging cell bodies of sensory neurons. BrendaTissueOBO dorsal root ganglion ganglion sensorium nervi spinalis ganglion spinale BTO:0001264 spinal ganglion BTO:0001268 One of the cells of the body that compose the tissues, organs, and parts of that individual other than the germ cells. BrendaTissueOBO BTO:0001268 somatic cell BTO:0001271 A cancer cell of the white blood cells. Leukaemias are grouped by how quickly the disease develops (acute or chronic) as well as by the type of blood cell that is affected. BrendaTissueOBO BTO:0001271 leukemia cell BTO:0001272 The posterior, filiform part of spermatozoa, which provides sperm motility. BrendaTissueOBO sperm tail BTO:0001272 sperm flagellum BTO:0001273 A sac for sperm storage in the female reproductive tract of various lower animals and especially insects. BrendaTissueOBO receptaculum seminis seminal receptacle spermathecum BTO:0001273 spermatheca BTO:0001274 One of the haploid cells that are formed by division of the secondary spermatocytes and that differentiate into spermatozoa. BrendaTissueOBO spermatoblast BTO:0001274 spermatid BTO:0001275 A cell giving rise to sperm cells; especially: a cell that is derived from a spermatogonium and ultimately gives rise to four haploid spermatids. BrendaTissueOBO BTO:0001275 spermatocyte BTO:0001276 The slender tube formed by the pollen grain that penetrates an ovule and releases the male gametes. BrendaTissueOBO BTO:0001276 pollen tube BTO:0001277 A motile male gamete of an animal usually with rounded or elongate head and a long posterior flagellum. BrendaTissueOBO male gamete mature sperm cell sperm cell spermatozoan zoosperm BTO:0001277 spermatozoon BTO:0001278 An elongated inflorescence similar to a raceme but having the flowers sessile on the main axis. BrendaTissueOBO BTO:0001278 spike BTO:0001279 The cord of nervous tissue that extends from the brain lengthwise along the back in the vertebral canal, gives off the pairs of spinal nerves, carries impulses to and from the brain, and serves as a center for initiating and coordinating many reflex acts. BrendaTissueOBO medulla spinalis spinal medulla BTO:0001279 spinal cord BTO:0001281 A highly vascular ductless organ that is located in the left abdominal region near the stomach or intestine of most vertebrates and is concerned with final destruction of red blood cells, filtration and storage of blood, and production of lymphocytes. BrendaTissueOBO BTO:0001281 spleen BTO:0001282 Human fibrosarcoma cell line; established from the biopsy from a fibrosarcoma of a 35-year-old Caucasian man in 1972; patient did not receive any chemo- or radiotherapy. BrendaTissueOBO BTO:0001282 HT-1080 cell BTO:0001284 The bone that extends from the pelvis to the knee, being the longest and largest bone in the body; its head articulates with the acetabulum of the hip bone, and distally, the femur, along with the patella and tibia, forms the knee joint. BrendaTissueOBO femoral bone os femorale os femoris thigh bone BTO:0001284 femur BTO:0001285 A stalk or similar structure bearing sporangia in plants and fungi. BrendaTissueOBO BTO:0001285 sporangiophore BTO:0001286 The two most common forms of skin cancer are basal cell carcinoma and squamous cell carcinoma. Together, these two are also referred to as nonmelanoma skin cancer. Melanoma is generally the most serious form of skin cancer because it tends to spread (metastasize) throughout the body quickly. BrendaTissueOBO skin carcinoma cell BTO:0001286 skin cancer cell BTO:0001287 A structure in which spores are produced. BrendaTissueOBO BTO:0001287 sporangium BTO:0001289 Carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization and often by preservation of intercellular bridges. Initially local and superficial, the lesion may later invade and metastasize. BrendaTissueOBO SCC cell epidermoid carcinoma cell prickle cell carcinoma cell BTO:0001289 squamous cell carcinoma cell BTO:0001292 A usually motile infective form of some sporozoans that is a product of sporogony and initiates an asexual cycle in the new host. BrendaTissueOBO BTO:0001292 sporozoite BTO:0001293 A sporozoan zygote undergoing sporogenous development. BrendaTissueOBO BTO:0001293 sporulated oocyst BTO:0001294 BrendaTissueOBO BTO:0001294 sporulating cell BTO:0001295 1: The skull of a vertebrate. 2: The portion of the skull enclosing the brain; the braincase. BrendaTissueOBO skeletal system of head skull BTO:0001295 cranium BTO:0001296 A young shoot (as from a seed or root). BrendaTissueOBO BTO:0001296 sprout BTO:0001297 Matter ejected from the lungs, bronchi, and trachea, through the mouth. BrendaTissueOBO expectoration BTO:0001297 sputum BTO:0001300 The main trunk of a plant; specifically: a primary plant axis that develops buds and shoots instead of roots. BrendaTissueOBO axis culm stalk BTO:0001300 stem BTO:0001302 A compound ventral bone or cartilage of most vertebrates other than fishes that connects the ribs or the shoulder girdle or both and in humans consists of the manubrium, gladiolus, and xiphoid process. BrendaTissueOBO breastbone BTO:0001302 sternum BTO:0001307 A dilatation of the alimentary canal of a vertebrate communicating anteriorly with the esophagus and posteriorly with the duodenum. BrendaTissueOBO gaster BTO:0001307 stomach BTO:0001308 The mucous coat of the stomach. BrendaTissueOBO Magenschleimhaut stomach mucosa tunica mucosa gastris BTO:0001308 gastric mucosa BTO:0001311 Either of a pair of masses of nervous tissue within the brain that contain two large nuclei of gray matter separated by sheets of white matter. BrendaTissueOBO striate body striated body striatum BTO:0001311 corpus striatum BTO:0001321 Human prostate carcinoma, established from the left supraclavicular lymph node metastasis from a 50-year-old man with prostate carcinoma in 1977; cells were described to be androgen-sensitive. BrendaTissueOBO LNCAP cell BTO:0001321 LNCaP cell BTO:0001325 The uppermost ganglion on the sympathetic trunk, lying behind the internal carotid artery and in front of the second and third cervical vertebrae; it gives rise to postganglionic fibers to the heart via cervical cardiac nerves, to the pharyngeal plexus and thence to the larynx and pharynx, and to the head via the external and internal carotid plexuses. BrendaTissueOBO ganglion cervicale superius BTO:0001325 superior cervical ganglion BTO:0001329 A tumor cell that secretes gastrin; most are islet cell tumors of non-beta cells in the pancreas, but some are found at sites such as the antrum of the stomach, the hilus of the spleen, or regional lymph nodes. This is the usual cause of Zollinger-Ellison syndrome. BrendaTissueOBO BTO:0001329 gastrinoma cell BTO:0001330 BrendaTissueOBO BTO:0001330 hepatoma ascites cell BTO:0001331 A simple tubular gland of the skin that secretes perspiration, is widely distributed in nearly all parts of the human skin, and consists typically of an epithelial tube extending spirally from a minute pore on the surface of the skin into the dermis or subcutaneous tissues where it ends in a convoluted tuft. BrendaTissueOBO glandula sudorifera sudoriferous gland sudoriparous gland BTO:0001331 sweat gland BTO:0001332 Human prostate carcinoma, established from the tumor tissue removed from the metastatic central nervous system lesion of a 69-year-old man with prostate carcinoma in 1975. BrendaTissueOBO DU145 cell BTO:0001332 DU-145 cell BTO:0001333 Any of the aggregations of cell bodies of primarily adrenergic neurons of the sympathetic nervous system, including the ganglia of the sympathetic trunks, the intermediate ganglia, the prevertebral ganglia, and some ganglionic cells in the autonomic plexuses. BrendaTissueOBO ganglion sympatheticum ganglion sympathicum BTO:0001333 sympathetic ganglion BTO:0001335 Syncytial layer that forms the outermost fetal layer in the placenta and is thus the interface with maternal tissue. Has invasive capacity - though in a regulated manner. BrendaTissueOBO syncytial trophoblast BTO:0001335 syncytiotrophoblast BTO:0001338 Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow. BrendaTissueOBO BTO:0001338 synovial tissue BTO:0001339 A transparent viscid lubricating fluid secreted by a membrane of an articulation, bursa, or tendon sheath. BrendaTissueOBO synovial fluid BTO:0001339 synovia BTO:0001340 Either of the two primary divisions of the trachea that lead respectively into the right and the left lung. BrendaTissueOBO bronchial tissue BTO:0001340 bronchus BTO:0001343 A muscle on the back of the forearm that extends the fingers and wrist. BrendaTissueOBO BTO:0001343 extensor digitorum communis BTO:0001345 Human urinary bladder carcinoma, established from the primary tumor of an 81-year-old Caucasian woman with urinary bladder carcinoma (transitional cell carcinoma, grade III) in 1970; described to produce a variety of cytokines (e.g. G-CSF, IL-6 and SCF) and to carry a p53 mutation. BrendaTissueOBO T24 cell BTO:0001345 T-24 cell BTO:0001346 Oval, quickly multiplying trophozoite of Toxoplasma gondii, found in all tissues except non-nucleated erythrocytes during the acute stage of toxoplasmosis. BrendaTissueOBO endocoite BTO:0001346 tachyzoite BTO:0001347 A larval amphibian; specifically: a frog or toad larva that has a rounded body with a long tail bordered by fins and external gills soon replaced by internal gills and that undergoes a metamorphosis to the adult. BrendaTissueOBO BTO:0001347 tadpole BTO:0001355 One of the two parietal lobes of the brain located behind the frontal lobe at the top of the brain. Parietal Lobe, Right - Damage to this area can cause visuo-spatial deficits (for example, the patient may have difficulty finding their way around new, or even familiar, places). Parietal Lobe, Left - Damage to this area may disrupt a patient's ability to understand spoken and/or written language. The parietal lobes contain the primary sensory cortex which controls sensation (touch, pressure). Behind the primary sensory cortex is a large association area that controls fine sensation (judgment of texture, weight, size, shape). BrendaTissueOBO temporal cortex BTO:0001355 temporal lobe BTO:0001356 A tough cord or band of dense white fibrous connective tissue that unites a muscle with some other part (as a bone) and transmits the force which the muscle exerts. BrendaTissueOBO BTO:0001356 tendon BTO:0001359 BrendaTissueOBO BTO:0001359 medulloblastoma cell line BTO:0001360 1: The part of the mucous membrane lining the uterus that in higher placental mammals undergoes special modifications in preparation for and during pregnancy and is cast off at parturition. 2: The part of the mucous membrane of the uterus cast off in the process of menstruation. BrendaTissueOBO uterine decidua BTO:0001360 decidua BTO:0001363 A typically paired male reproductive gland that produces sperm and that in most mammals is contained within the scrotum at sexual maturity. BrendaTissueOBO male gonad orchis testicle testiculus BTO:0001363 testis BTO:0001365 The largest subdivision of the diencephalon that consists chiefly of an ovoid mass of nuclei in each lateral wall of the third ventricle and functions in the integration of sensory information. BrendaTissueOBO dorsal thalamus thalamus dorsalis BTO:0001365 thalamus BTO:0001367 BrendaTissueOBO BTO:0001367 thigh muscle BTO:0001368 1: The part of the mammalian body between the neck and the abdomen; also: its cavity in which the heart and lungs lie. 2: The middle of the three chief divisions of the body of an insect; also: the corresponding part of a crustacean or an arachnid. BrendaTissueOBO chest BTO:0001368 thorax BTO:0001374 A glandular structure of largely lymphoid tissue that functions especially in the development of the body's immune system, is present in the young of most vertebrates typically in the upper anterior chest or at the base of the neck, and tends to atrophy in the adult. BrendaTissueOBO BTO:0001374 thymus BTO:0001377 BrendaTissueOBO thymic lymphoma cell line BTO:0001377 thymus lymphoma cell line BTO:0001379 A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin. BrendaTissueOBO thyroid BTO:0001379 thyroid gland BTO:0001385 A fleshy movable process of the floor of the mouths of most vertebrates that bears sensory end organs and small glands and functions especially in taking and swallowing food and in humans as a speech organ. BrendaTissueOBO BTO:0001385 tongue BTO:0001387 The human palatine tonsils and the nasopharyngeal tonsil are lymphoepithelial tissues located in strategic areas of the oropharynx and nasopharynx, although most commonly, the term tonsils refers to the palatine tonsils that can be seen in the back of the throat. BrendaTissueOBO Mandel BTO:0001387 tonsil BTO:0001388 1: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. It is kept patent by a series of about twenty transverse horseshoe-shaped cartilages. Called also windpipe. 2: One of a system of minute tubes ramifying throughout the body of a terrestrial arthropod and delivering air to the tissues. Called also tracheal tubule. BrendaTissueOBO tracheal tubule windpipe BTO:0001388 trachea BTO:0001391 BrendaTissueOBO BTO:0001391 tracheal smooth muscle BTO:0001393 The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop. BrendaTissueOBO BTO:0001393 mesenchyme BTO:0001395 A filamentous outgrowth; especially: an epidermal hair structure on a plant. BrendaTissueOBO BTO:0001395 trichome BTO:0001397 A protozoan, especially of the class Sporozoa, in the active stage of its life cycle. BrendaTissueOBO BTO:0001397 trophozoite BTO:0001398 Any of the bodies representing the morphologic (trypanosomal) stage in the life cycle of certain trypanosomatid protozoa, resembling the typical adult form of members of the genus Trypanosoma, in which the slender elongate cell has a kinetoplast and basal body located at the posterior end and a flagellum running anteriorly along an undulating membrane to become a free-flowing structure. BrendaTissueOBO BTO:0001398 trypomastigote BTO:0001400 A short fleshy usually underground stem bearing minute scale leaves each of which bears a bud in its axil and is potentially able to produce a new plant. BrendaTissueOBO BTO:0001400 tuber BTO:0001402 A pair of dorsolateral mesodermal ridges in the vertebrate embryo out of which the urogenital organs are developed. BrendaTissueOBO BTO:0001402 urogenital ridge BTO:0001403 An early metazoan embryo in which the ectoderm, mesoderm, and endoderm are established either by invagination of the blastula (as in fish and amphibians) to form a multilayered cellular cup with a blastopore opening into the archenteron or by differentiation of the blastodisc (as in reptiles, birds, and mammals) and inward cellular migration. BrendaTissueOBO BTO:0001403 gastrula BTO:0001407 A cell of any of a diverse group of tumors containing neurosecretory cells that cause endocrine dysfunction, most are carcinoids or carcinomas. They occur most often in the gastrointestinal tract, in bronchial and tracheal mucous membranes, and in teratoid ovarian tumors. BrendaTissueOBO NET cell neuroendocrine carcinoma cell BTO:0001407 neuroendocrine tumor cell BTO:0001409 The tube that carries urine from the kidney to the bladder. BrendaTissueOBO BTO:0001409 ureter BTO:0001410 Rat pituitary tumor, derived in 1965 from a pituitary tumor induced in a female Wistar/Furth rat ollowing repeated transplantation with the MtT/W5 tumor (originally induced in a female F/Fu rat by cranial X-irradiation). BrendaTissueOBO BTO:0001410 GH3 cell BTO:0001412 Human histiocytic lymphoma established from the pleural effusion of a 37-year-old man with generalized diffuse histiocytic lymphoma in 1974. Cells were described to express markers and properties of monocytes; Human leukemic monocyte lymphoma cell line. BrendaTissueOBO U937 cell BTO:0001412 U-937 cell BTO:0001415 A cord arising from the navel that connects the fetus with the placenta. BrendaTissueOBO yolk stalk BTO:0001415 umbilical cord BTO:0001418 A membranous sac in many vertebrates that serves for the temporary retention of urine and discharges by the urethra. BrendaTissueOBO vesica BTO:0001418 urinary bladder BTO:0001419 Waste material that is secreted by the kidney in vertebrates, is rich in end products of protein metabolism together with salts and pigments, and forms a clear amber and usually slightly acid fluid in mammals but is semisolid in birds and reptiles. BrendaTissueOBO BTO:0001419 urine BTO:0001421 A constricted portion of an organ or part; especially: the narrow outer end of the uterus. BrendaTissueOBO cervix cervix of uterus neck of uterus BTO:0001421 uterine cervix BTO:0001422 The mucous membrane lining the uterus. BrendaTissueOBO endometrium uterine mucous membrane BTO:0001422 uterine endometrium BTO:0001424 An organ of the female mammal for containing and usually for nourishing the young during development previous to birth. BrendaTissueOBO womb BTO:0001424 uterus BTO:0001426 The tube through which urine leaves the body. It empties urine from the bladder. BrendaTissueOBO BTO:0001426 urethra BTO:0001427 A spermatic duct especially of a higher vertebrate that in the human male is a thick-walled tube about two feet (0.61 meters) long that begins at and is continuous with the tail of the epididymis and eventually joins the duct of the seminal vesicle to form the ejaculatory duct. BrendaTissueOBO deferent duct ductus deferens BTO:0001427 vas deferens BTO:0001431 BrendaTissueOBO BTO:0001431 vascular smooth muscle BTO:0001433 Any cell of the monocyte-macrophage lineage, including macrophages, monocytes, and their precursors in the monocytic series. BrendaTissueOBO BTO:0001433 mononuclear phagocyte BTO:0001434 1: Growing or having the power of growing. 2: Of, relating to, or engaged in nutritive and growth functions as contrasted with reproductive functions. BrendaTissueOBO vegetative BTO:0001434 vegetative cell BTO:0001437 BrendaTissueOBO BTO:0001437 embryonic carcinoma cell line BTO:0001438 Any of the large veins by which in air-breathing vertebrates the blood is returned to the right atrium of the heart. BrendaTissueOBO BTO:0001438 vena cava BTO:0001439 Poisonous matter normally secreted by some animals (as snakes, scorpions, or bees) and transmitted to prey or an enemy chiefly by biting or stinging; broadly: material that is poisonous. BrendaTissueOBO BTO:0001439 venom BTO:0001440 The venom gland of snakes is in actual fact a modified salivary gland and is linked to the groove in the fangs by a duct; A bee has a poison gland in her abdomen. BrendaTissueOBO poison gland BTO:0001440 venom gland BTO:0001441 Any of the immature blood cells that develop in the bone marrow, such as those involved in hematopoiesis. BrendaTissueOBO myeloid cell BTO:0001441 marrow cell BTO:0001444 The Vero cell line was initiated from the kidney of a normal adult African green monkey on March 27, 1962, by Y. Yasumura and Y. Kawakita at the Chiba University in Chiba, Japan. BrendaTissueOBO BTO:0001444 Vero cell BTO:0001445 The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node. BrendaTissueOBO end bud tailbud BTO:0001445 tail bud BTO:0001450 The cytoplasmic, noncellular membrane surrounding the eggs of various animals, especially the membrane enveloping the yolk of telolecithal eggs. BrendaTissueOBO yolk sac membrane BTO:0001450 vitelline membrane BTO:0001453 The outer largely longitudinally arranged musculature of the bladder wall. BrendaTissueOBO detrusor muscle BTO:0001453 detrusor BTO:0001454 Thymoma is a disease in which cancer (malignant) cells are found in the tissues of the thymus. Thymoma is usually a slow-growing tumor that does not spread beyond the thymus. BrendaTissueOBO BTO:0001454 thymoma cell BTO:0001455 Thymic carcinoma is a disease in which cancer (malignant) cells are found in the tissues of the thymus. Thymic carcinoma is difficult to treat and generally spreads to other parts of the body. People with thymoma often have other diseases of the immune system, most commonly myasthenia gravis, a disease in which the muscles become weak. BrendaTissueOBO BTO:0001455 thymic carcinoma cell BTO:0001456 The adipose tissue comprising the bulk of the body fat. BrendaTissueOBO BTO:0001456 white adipose tissue BTO:0001457 The laterally projecting region of each side of the lower or posterior part of the mammalian trunk formed by the lateral parts of the pelvis and upper part of the femur together with the fleshy parts covering them. BrendaTissueOBO BTO:0001457 hip BTO:0001460 BrendaTissueOBO BTO:0001460 thymic cancer cell BTO:0001461 The main part of a plant. BrendaTissueOBO Pflanzenkoerper BTO:0001461 whole plant BTO:0001462 BrendaTissueOBO BTO:0001462 bladder wall BTO:0001464 The entire dorsal mesothoracic disc (wing, notal, and pleural parts), in the larval stage of Drosophila. BrendaTissueOBO wing imaginal disc BTO:0001464 wing disc BTO:0001470 Cell of epidermis in animals. BrendaTissueOBO BTO:0001470 epidermal cell BTO:0001471 A membranous sac that is attached to an embryo and encloses food yolk, that is continuous in most forms through the yolk stalk with the intestinal cavity of the embryo, that being abundantly supplied with blood vessels is throughout embryonic life and in some forms later the chief organ of nutrition, and that in placental mammals is nearly vestigial and functions chiefly prior to the elaboration of the placenta. BrendaTissueOBO BTO:0001471 yolk sac BTO:0001473 A cell produced during cleavage of a fertilized egg. BrendaTissueOBO cleavage cell segmentation sphere BTO:0001473 blastomere BTO:0001474 BrendaTissueOBO BTO:0001474 yolk sac erythroid cell BTO:0001481 Any of a kingdom (Plantae) of living things typically lacking locomotive movement or obvious nervous or sensory organs and possessing cellulose cell walls. BrendaTissueOBO Pflanze plantae viridiplantae BTO:0001481 plant BTO:0001483 Human, colon, adenocarcinoma cell line. BrendaTissueOBO BTO:0001483 WiDr cell BTO:0001484 The nervous system is essentially a biological information highway, and is responsible for controlling all the biological processes and movement in the body, and can also receive information and interpret it via electrical signals which are used in this nervous system. It consists of the Central Nervous System (CNS), essentially the processing area and the Peripheral Nervous System which detects and sends electrical impulses that are used in the nervous system. BrendaTissueOBO Nervensystem BTO:0001484 nervous system BTO:0001485 The bodily system that is composed of skeletal, smooth, and cardiac muscle tissue and functions in movement of the body or of materials through the body, maintenance of posture, and heat production. BrendaTissueOBO Muskelsystem muscle system musculature musculature system BTO:0001485 muscular system BTO:0001487 Connective tissue in which fat is stored and which has the cells distended by droplets of fat. BTO:0000441 BrendaTissueOBO adipose bodyfat fat fat tissue BTO:0001487 adipose tissue BTO:0001488 Any of various glands producing hormonal secretions that pass directly into the bloodstream. The endocrine glands include the thyroid, parathyroids, anterior and posterior pituitary, pancreas, adrenals, pineal, and gonads. BrendaTissueOBO ductless gland BTO:0001488 endocrine gland BTO:0001489 The main part of an animal body especially as distinguished from limbs and head. BrendaTissueOBO Koerper BTO:0001489 whole body BTO:0001491 An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper. BrendaTissueOBO Organsystem splanchnic tissue visceral tissue BTO:0001491 viscus BTO:0001492 1. One of the projecting paired appendages (as wings) of an animal body used especially for movement and grasping but sometimes modified into sensory or sexual organs. 2. A leg or arm of a human being. BrendaTissueOBO Extremitaet BTO:0001492 limb BTO:0001498 The convoluted portion of the vertebrate nephron that lies between Bowman's capsule and the loop of Henle and functions especially in the resorption of sugar, sodium and chloride ions, and water from the glomerular filtrate. BrendaTissueOBO proximal convoluted tubule proximal tubule BTO:0001498 renal proximal tubule BTO:0001500 A leaf, stipule, or stem modified into a slender spirally coiling sensitive organ serving to attach a climbing plant to its support. BrendaTissueOBO BTO:0001500 tendril BTO:0001501 1: A slender threadlike outgrowth of the epidermis of an animal; especially: one of the usually pigmented filaments that form the characteristic coat of a mammal. 2: The hairy covering of an animal or a body part; especially: the coating of hairs on a human head. BrendaTissueOBO BTO:0001501 hair BTO:0001509 A vein that passes through the umbilical cord to the fetus and returns the oxygenated and nutrient blood from the placenta to the fetus. BrendaTissueOBO BTO:0001509 umbilical vein BTO:0001510 BrendaTissueOBO BTO:0001510 rectal cell line BTO:0001514 BrendaTissueOBO BTO:0001514 biliary epithelial cell BTO:0001516 Mouse pro B cell line. IL-3 dependent murine pro B cell line established from peripheral blood; apparently derived from BALB/c mouse. BrendaTissueOBO BTO:0001516 BA/F3 cell BTO:0001518 BrendaTissueOBO B-cell lymphoma cell line BTO:0001518 B-lymphoma cell line BTO:0001519 BrendaTissueOBO BTO:0001519 endothelial cell line BTO:0001520 BrendaTissueOBO BTO:0001520 umbilical vein endothelial cell line BTO:0001521 BrendaTissueOBO BTO:0001521 pancreatic adenocarcinoma cell line BTO:0001522 BrendaTissueOBO B-cell line BTO:0001522 B-lymphocyte cell line BTO:0001526 BrendaTissueOBO BTO:0001526 renal medulla cell line BTO:0001528 BrendaTissueOBO BTO:0001528 B-lymphoblast BTO:0001530 BrendaTissueOBO BTO:0001530 glioblastoma cell line BTO:0001531 BrendaTissueOBO BTO:0001531 glial cell line BTO:0001532 BrendaTissueOBO rectal tumor cell line BTO:0001532 rectal cancer cell line BTO:0001533 BrendaTissueOBO BTO:0001533 gastrointestinal cancer cell BTO:0001534 Human colon adenocarcinoma, established from the colon tumor of a 81-year-old Caucasian woman with colon adenocarcinoma. BrendaTissueOBO SW948 cell BTO:0001534 SW-948 cell BTO:0001538 African green monkey kidney cell line; established from CV-1 Simian cells (cercopithecus aethiops) which were transformed by an origin-defective mutant of SV-40; cells are host cells for the propagation of pure populations of recombinant SV virus. BrendaTissueOBO COS1 cell BTO:0001538 COS-1 cell BTO:0001539 The tissue characteristic of an organ, as distinguished from associated connective or supporting tissues. Marion 2013-11-07T09:33:34Z BrendaTissueOBO BTO:0001539 parenchyma BTO:0001541 1. The primordial kidney; a vestigial excretory structure or its rudiments developing in the embryo at four weeks, before the mesonephros. Although nonfunctional, its duct is later used by the mesonephros, which arises caudal to it. 2. The definitive excretory organ of primitive fishes. BrendaTissueOBO anterior kidney archinephron embryonic kidney head kidney pronephron BTO:0001541 pronephros BTO:0001542 The excretory organ of the embryo, arising caudal to the pronephros or pronephric rudiments and using its duct; it consists of a long tube in the lower part of the body cavity, running parallel with the vertebral axis and joined at right angles by a row of twisting tubes. BrendaTissueOBO corpus Wolffi mesonephric kidney mesonephros middle kidney wolffian body BTO:0001542 mesonephron BTO:0001543 The primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; Either member of the final and most caudal pair of the three successive pairs of vertebrate renal organs that functions as a permanent adult kidney in reptiles, birds, and mammals but is not present at all in lower forms. BrendaTissueOBO definite kidney definitive kidney hind kidney metanephros BTO:0001543 metanephron BTO:0001544 Neoplasia of myeloid stem cells, commonest in middle-aged or elderly people, characterized by excessive numbers of circulating leucocytes, most commonly neutrophils (or precursors), but occasionally eosinophils or basophils. BrendaTissueOBO CML cell cronic myelogenous leukemia cell BTO:0001544 chronic myeloid leukemia cell BTO:0001545 Adult acute myeloid leukemia (AML) is a disease in which cancer (malignant) cells are found in the blood and bone marrow. More common in adults, the proliferating cells are of the myeloid hematopoietic series and the cells appearing in the blood are primitive granulocytes or monocytes. BrendaTissueOBO AML cell acute myeloblastic leukemia cell acute myelogenous leukemia cell BTO:0001545 acute myeloid leukemia cell BTO:0001546 Cell of a neoplastic disease of middle or old age, characterized by excessive numbers of circulating lymphocytes of normal, mature appearance, usually B-lymphocytes; presumably a neoplastic transformation of lymphoid stem cells. BrendaTissueOBO CLL cell BTO:0001546 chronic lymphocytic leukemia cell BTO:0001547 One of the modified leaves comprising a calyx. BrendaTissueOBO BTO:0001547 sepal BTO:0001551 BrendaTissueOBO BTO:0001551 free-living state BTO:0001553 Human Caucasian colon adenocarcinoma cell line. BrendaTissueOBO LS 174T cell LS174T cell BTO:0001553 LS-174T cell BTO:0001555 Marion 2010-01-28T06:07:46Z BrendaTissueOBO endometrial carcinoma cell line BTO:0001555 endometrial cancer cell line BTO:0001557 Human glioblastoma cell line. BrendaTissueOBO SF767 cell BTO:0001557 SF-767 cell BTO:0001558 A segmental mass of mesoderm in the vertebrate embryo, occurring in pairs along the notochord and developing into muscles and vertebrae. BrendaTissueOBO BTO:0001558 somite BTO:0001560 BrendaTissueOBO BTO:0001560 testicular cancer cell line BTO:0001561 Human Burkitt's lymphoma cell line; established from the Burkitt's lymphoma (left orbital biopsy) of a 16-year-old African boy in 1967; cells were described to be EBV-positive and to express mRNA for proto-oncogene bcl-2. BrendaTissueOBO BTO:0001561 DAUDI cell BTO:0001572 A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints. BrendaTissueOBO hyaline cartilage BTO:0001572 articular cartilage BTO:0001573 Cancer cell of the central information processing center of the body. Tumors in the brain can be malignant or benign, and can occur at any age. Only malignant tumors are cancerous. Primary brain tumors cancer initially forms in the brain tissue. Secondary brain tumors cancers are cancers that have spread to the brain tissue (metastasized) from elsewhere in the body. Secondary brain cancer is named for the organ or tissue in which the cancer begins, such as lung cancer with secondary brain metastasis. BrendaTissueOBO brain tumor cell intracranial tumor cell BTO:0001573 brain cancer cell BTO:0001575 BrendaTissueOBO BTO:0001575 choriocarcinoma cell line BTO:0001577 Tumor cell or cancer cell of the esophagus. BrendaTissueOBO BTO:0001577 esophageal cancer cell BTO:0001579 Any of six small voluntary muscles that pass between the eyeball and the orbit and control the movement of the eyeball in relation to the orbit. BrendaTissueOBO extra-ocular muscle extrinsic muscle of eyeball BTO:0001579 extraocular muscle BTO:0001580 Either of the paired ducts in the human male that are formed by the junction of the duct from the seminal vesicle with the vas deferens, pass through the prostate, and open into or close to the prostatic utricle. BrendaTissueOBO ductus ejaculatorius BTO:0001580 ejaculatory duct BTO:0001581 BrendaTissueOBO ES cell line BTO:0001581 embryonic stem cell line BTO:0001583 Human brain glioblastoma multiforme cell line, established from a 61 years old caucasian male. BrendaTissueOBO T-98 cell T98 cell T98G cell BTO:0001583 T-98G cell BTO:0001584 Homo sapiens (human); skin; malignant melanoma cell line; established from a 31 year old caucasian male. BrendaTissueOBO BTO:0001584 G-361 cell BTO:0001586 BrendaTissueOBO BTO:0001586 lymphoid cell line BTO:0001591 Human ovary ascites teratocarcinoma cell line. The line was established from cells taken from ascitic fluid. BrendaTissueOBO BTO:0001591 PA-1 cell BTO:0001593 A cell from which bone develops; a bone-forming cell. BrendaTissueOBO BTO:0001593 osteoblast BTO:0001596 Homo sapiens (human) bone, osteosarcoma cell line; established from a 14 year old caucasian male. BrendaTissueOBO MG63 cell BTO:0001596 MG-63 cell BTO:0001597 A young tree; specifically: one not over four inches in diameter at breast height. BrendaTissueOBO BTO:0001597 sapling BTO:0001598 A macrophage of the spleen. BrendaTissueOBO BTO:0001598 splenocyte BTO:0001600 A layer of more or less solid substance which covers the free surface of an epithelial cell. BrendaTissueOBO cuticula BTO:0001600 cuticle BTO:0001605 A trabeculum of loose fibers found at the iridocorneal angle between the anterior chamber of the eye and the venous sinus of the sclera; the aqueous humor filters through the spaces between the fibers into the sinus and passes into the bloodstream. The reticulum is divided into a corneoscleral part and a uveal part; An area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber. The tissue is spongy and lined by trabeculocytes; it allows fluid to drain into a set of tubes called Schlemm's canal flowing into the blood system. BrendaTissueOBO Hueck's ligament ligamentum pectinatum anguli iridocornealis pectinate ligament pectinate ligament of iris trabecular meshwork BTO:0001605 reticulum trabeculare BTO:0001607 The air bladder of a fish. BrendaTissueOBO air bladder BTO:0001607 swim bladder BTO:0001610 BrendaTissueOBO BTO:0001610 thyroid cancer cell line BTO:0001611 Cell line derived from anaplastic thyroid carcinoma. BrendaTissueOBO SW1736 cell BTO:0001611 SW-1736 cell BTO:0001612 BrendaTissueOBO BTO:0001612 colorectal adenoma cell BTO:0001613 The colon and rectum considered as a unit. BrendaTissueOBO BTO:0001613 colorectum BTO:0001614 BrendaTissueOBO BTO:0001614 colorectal cell line BTO:0001615 BrendaTissueOBO CRC cell colorectal carcinoma cell BTO:0001615 colorectal cancer cell BTO:0001616 BrendaTissueOBO CRC cell line BTO:0001616 colorectal cancer cell line BTO:0001619 BrendaTissueOBO BTO:0001619 skin fibroblast cell line BTO:0001620 Human, Caucasian, bone marrow, neuroblastoma cell line. Species: human, Caucasian female 4 years old; Tissue: bone marrow; Tumor: neuroblastoma. BrendaTissueOBO BTO:0001620 SK-N-SH cell BTO:0001622 A cell of a tumor arising from fibroblasts, divided into fibromas and fibrosarcomas. BrendaTissueOBO BTO:0001622 fibroblastoma cell BTO:0001625 Cancer or tumor cell of the larynx or any of its parts: the glottis, epiglottis, laryngeal cartilages, laryngeal muscles, and vocal cords. BrendaTissueOBO BTO:0001625 laryngeal cancer cell BTO:0001626 The intrinsic muscles of the larynx are the aryepiglottic(us), arytenoid(eus), cricoarytenoid(eus), cricothyroid(eus), thyroarytenoid(eus), thyroepiglottic(us) and vocal(is). BrendaTissueOBO BTO:0001626 laryngeal muscle BTO:0001629 The ventricles are the two lower chambers of the heart. The left ventricle is the chamber that receives blood from the left atrium and pumps it out under high pressure to the body via the aorta. BrendaTissueOBO BTO:0001629 left ventricle BTO:0001631 A malignant tumor cell of smooth muscle origin. Smooth muscle is the major structural component of most hollow internal organs and the walls of blood vessels. Can occur almost anywhere in the body but is most frequent in the uterus and gastrointestinal tract. Complete surgical excision, if possible, is the treatment of choice. BrendaTissueOBO BTO:0001631 leiomyosarcoma cell BTO:0001639 Any small part of the embryo or adult metazoon more or less resembling the bud of a plant and presumed to have potential for growth and differentiation. BrendaTissueOBO BTO:0001639 bud BTO:0001646 An outgrowth of the mesonephric duct that gives rise to all but the nephrons of the permanent kidney. BrendaTissueOBO diverticulum metanephric bud BTO:0001646 ureteric bud BTO:0001655 In conifers, the reproductive parts are housed within the cones. A conifer has two kinds of cones, the pollen, or male, cone is the small and soft. A pollen cone has many tiny sporangia that produce pollen grains. The wind usually delivers the pollen grains from the pollen cone to the seed cone, this is the yellow haze often seen in the spring in coniferous forest areas. BrendaTissueOBO pollen cone BTO:0001655 male cone BTO:0001656 1. The pair of closely united ventral longitudinal nerves with their segmental ganglia that is characteristic of many elongate invertebrates (as earthworms). 2. The dorsal tubular cord of nervous tissue above the notochord of a chordate that comprises or develops into the central nervous system. BrendaTissueOBO BTO:0001656 nerve cord BTO:0001657 The region at the base of a leaf, flower, fruit, or other plant part, where the formation of a cork layer results in the separation of that part from the plant body. BrendaTissueOBO abscission layer separation layer BTO:0001657 abscission zone BTO:0001658 Existing or growing in the air rather than in the ground or in water. BrendaTissueOBO aerial body aerial tissue BTO:0001658 aerial part BTO:0001660 BrendaTissueOBO ASM cell airway smooth muscle airway smooth muscle cell BTO:0001660 respiratory smooth muscle BTO:0001664 BrendaTissueOBO BTO:0001664 hepatoblastoma cell line BTO:0001666 A malignant intrahepatic tumor occurring in infants and young children and consisting chiefly of embryonic hepatic tissue. BrendaTissueOBO BTO:0001666 hepatoblastoma cell BTO:0001668 BrendaTissueOBO BTO:0001668 mast cell line BTO:0001676 A cell line which originated from a pheochromocytoma in rat adrenal medulla. BrendaTissueOBO PC12D cell BTO:0001676 PC-12D cell BTO:0001677 Insect - fruitfly (Drosophila melanogaster) cell line, established from the late embryo of a Drosophila melanogaster (fruitfly) in 1972; originally the cells were diploid with 5-10% XY, currently the cell line has only XX cells that are now 60-80% tetraploid. BrendaTissueOBO S-2 cell S2 cell SCHNEIDER S2 Cell SL-2 cell SL2 cell Schneider cell Schneider's Line S2 cell BTO:0001677 SCHNEIDER-2 cell BTO:0001683 BrendaTissueOBO anterior pituitary gland tumor cell anterior pituitary tumor cell BTO:0001683 adenohypophysis tumor cell BTO:0001685 BrendaTissueOBO aorta smooth muscle aortic vascular smooth muscle BTO:0001685 aortic smooth muscle BTO:0001686 The point of contact between elements of an animal skeleton with the parts that surround and support it. BrendaTissueOBO articular joint BTO:0001686 joint BTO:0001690 A cell of a group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. BrendaTissueOBO B-lymphoma cell BTO:0001690 B-cell lymphoma cell BTO:0001691 The organ, resting on the basilar membrane in the cochlear duct, that contains the special sensory receptors for hearing; it consists of neuroepithelial hair cells and several types of supporting cells, including the inner and outer pillar cells, inner and outer phalangeal cells, border cells, and Hensen's cells. BrendaTissueOBO Corti's organ basilar papilla organ of Corti organum spirale spiral organ of Corti BTO:0001691 spiral organ BTO:0001700 Bone substance made up of thin intersecting lamellae, usually found internal to compact bone. BrendaTissueOBO cancellated bone spongy bone substantia spongiosa ossium substantia trabecularis ossium trabecular bone trabecular substance BTO:0001700 cancellous bone BTO:0001705 The largest papilla of the tongue, 8 to 12 in number, arranged in the form of a V anterior to the sulcus terminalis of the tongue. BrendaTissueOBO circumvallate papilla papilla vallatae BTO:0001705 vallate papilla BTO:0001709 BrendaTissueOBO colon epithelium BTO:0001709 colonic epithelium BTO:0001711 A pigment cell that contains melanin, especially as found in the skin of amphibians and reptiles. BrendaTissueOBO BTO:0001711 melanophore BTO:0001713 The back; especially : the entire dorsal surface of an animal. BrendaTissueOBO back BTO:0001713 dorsum BTO:0001716 The hard exterior covering of an egg. BrendaTissueOBO egg shell BTO:0001716 eggshell BTO:0001718 Embryoid bodies are structures resembling embryos, occurring in several types of germ cell tumors. BrendaTissueOBO BTO:0001718 embryoid body BTO:0001719 1. A sharp, curved, horny structure at the end of a toe of a mammal, reptile, or bird. 2. A chela or similar pincerlike structure on the end of a limb of a crustacean or other arthropod. 3. A limb terminating in such a structure. BrendaTissueOBO BTO:0001719 claw BTO:0001734 BrendaTissueOBO BTO:0001734 gut juice BTO:0001739 A thin plate of cells that is an extension of the adenohypophysis on the ventral or anterior aspect of the infundibulum. BrendaTissueOBO BTO:0001739 pars tuberalis BTO:0001741 A tooth adapted for cutting or gnawing, located at the front of the mouth along the apex of the dental arch. BrendaTissueOBO BTO:0001741 incisor BTO:0001742 BrendaTissueOBO BTO:0001742 jejunal mucosa BTO:0001744 Any of several large veins of the neck that drain blood from the head. BrendaTissueOBO vena jugularis BTO:0001744 jugular vein BTO:0001748 1: The lower jaw of a vertebrate animal. 2: Either the upper or lower part of the beak in birds. BrendaTissueOBO inferior maxillary bone lower jaw bone mandibula BTO:0001748 mandible BTO:0001756 A cell of a slow-growing tumor of the meninges, occurring most often in adults. BrendaTissueOBO BTO:0001756 meningioma cell BTO:0001757 A cell of a malignant, highly radiosensitive cerebellar tumor composed of undifferentiated neuroglial cells. BrendaTissueOBO BTO:0001757 medulloblastoma cell BTO:0001758 A small simple eye, found in many invertebrates, usually consisting of a few sensory cells and a single lens. BrendaTissueOBO BTO:0001758 ocellus BTO:0001760 A developmental stage of a muscle fiber composed of a syncytium formed by fusion of myoblasts. BrendaTissueOBO BTO:0001760 myotube BTO:0001762 A newborn child; especially: a child less than a month old. BrendaTissueOBO BTO:0001762 neonate BTO:0001764 The part of the ectoderm in a vertebrate embryo that lies on either side of the neural tube and develops into the cranial, spinal, and autonomic ganglia. BrendaTissueOBO BTO:0001764 neural crest BTO:0001766 An embryo at an early stage of development in which neurulation begins. BrendaTissueOBO BTO:0001766 neurula BTO:0001770 The ciliary epithelium produces the aqueous humor of the eye. BrendaTissueOBO ciliary body epithelium BTO:0001770 ciliary epithelium BTO:0001772 The specialized structures subserving the function of the sense of smell, including the olfactory region of the nasal mucosa containing the bipolar cells of origin of the olfactory nerves, together with the olfactory glands. BrendaTissueOBO olfactory neuroepithelium organ olfactus organum olfactorium BTO:0001772 olfactory organ BTO:0001773 Zygote, specifically a sporozoan zygote undergoing sporogenous development. BrendaTissueOBO BTO:0001773 oocyst BTO:0001774 Cancer within the mouth. BrendaTissueOBO BTO:0001774 oral cancer cell BTO:0001779 The roof of the mouth separating the mouth from the nasal cavity. BrendaTissueOBO BTO:0001779 palate BTO:0001780 Cells of the gastric glands which secrete hydrochloric acid and intrinsic factor. BrendaTissueOBO parietal cell BTO:0001780 oxyntic cell BTO:0001785 One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of a vertebrate embryo, consist typically of a curved segmented bar or rod on each side meeting the contralateral bar or rod at the ventral end, and correspond to the gill arches of fishes and amphibians. BrendaTissueOBO pharyngeal arch visceral arch BTO:0001785 branchial arch BTO:0001786 BrendaTissueOBO BTO:0001786 pheromone gland BTO:0001791 The delicate serous membrane that lines each half of the thorax of mammals and is folded back over the surface of the lung of the same side. BrendaTissueOBO pleural tissue BTO:0001791 pleura BTO:0001792 A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver. BrendaTissueOBO BTO:0001792 portal vein BTO:0001793 The dorsal part of the midbrain including the corpora quadrigemina. BrendaTissueOBO neuraxis tectum tectum BTO:0001793 tectum mesencephali BTO:0001799 A vein that carries oxygenated blood from the lungs to the left atrium of the heart. BrendaTissueOBO BTO:0001799 pulmonary vein BTO:0001800 Cells of the innermost nuclear layer of the retina, the ganglion cell layer, which project axons through the optic nerve to the brain. They are quite variable in size and in the shapes of their dendritic arbors, which are generally confined to the inner plexiform layer. BrendaTissueOBO BTO:0001800 retinal ganglion cell BTO:0001801 BrendaTissueOBO BTO:0001801 skeletal muscle cancer cell BTO:0001802 Malignant tumour (sarcoma) derived from striated muscle. BrendaTissueOBO BTO:0001802 rhabdomyosarcoma cell BTO:0001803 Corpora allata with Corpora cardiaca form the retrocerebral complex, a neurosecretory organ. BrendaTissueOBO BTO:0001803 retrocerebral complex BTO:0001806 The visceral mass consists of the gonad, digestive gland, heart, and excretory organs. BrendaTissueOBO BTO:0001806 visceral mass BTO:0001808 Either of two main superficial veins of the leg, one larger than the other, that begin at the foot. BrendaTissueOBO BTO:0001808 saphenous vein BTO:0001809 The part of the integument of the human head usually covered with hair in both sexes or the part of an animal (as a wolf or fox) corresponding to the human scalp. BrendaTissueOBO BTO:0001809 scalp BTO:0001811 Specialised epithelium lining the seminiferous tubules containing developing and mature spermatozoa and sertoli cells. BrendaTissueOBO BTO:0001811 seminiferous epithelium BTO:0001814 The outer end of a leaf; the end that is opposite the petiole. BrendaTissueOBO leaf apex BTO:0001814 leaf tip BTO:0001819 The upper part of the spiral ligament of the scala media that contains numerous small blood vessels; A layer of vascular tissue consisting of epithelial cells, mesothelial cells, and probably some neuroectoderm; it covers the outer wall of the cochlear duct and is thought to secrete the endolymph. BrendaTissueOBO stria vascularis ductus cochlearis vascular stria of cochlear duct BTO:0001819 stria vascularis BTO:0001820 An ependymal derivative located at the junction of the third ventricle and the cerebral aqueduct, secreting somatostatin. BrendaTissueOBO BTO:0001820 subcommissural organ BTO:0001822 A small group of neurons situated immediately dorsal to the optic chiasma in the anterior hypothalamus. BrendaTissueOBO SCN BTO:0001822 suprachiasmatic nucleus BTO:0001823 The dense connective-tissue membrane that secretes synovial fluid and that lines the ligamentous surfaces of articular capsules, tendon sheaths where free movement is necessary, and bursae. BrendaTissueOBO synovial membrane BTO:0001823 synovium BTO:0001824 A cell of a malignant neoplasm arising in the synovial membrane of the joints and also in synovial cells of tendons and bursae. BrendaTissueOBO malignant synovioma cell synoviosarcoma cell BTO:0001824 synovial sarcoma cell BTO:0001825 A disease in which certain cells of the lymph system (called T-lymphocytes) become cancerous. BrendaTissueOBO BTO:0001825 T-cell lymphoma cell BTO:0001827 A fin at the posterior part of the body of a fish, crustacean, whale, or other aquatic animal. BrendaTissueOBO caudal fin tailfin BTO:0001827 tail fin BTO:0001829 The dark-brown vascular coat of the eye between the sclera and the retina. BrendaTissueOBO chorioid choroid coat choroid membrane BTO:0001829 choroid BTO:0001830 The terminal male inflorescence of some plants and especially Indian corn. BrendaTissueOBO BTO:0001830 tassel BTO:0001832 One of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord, and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera, and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. BrendaTissueOBO sympathetic part of autonomic division of nervous system BTO:0001832 sympathetic nervous system BTO:0001833 One of the two divisions of the vertebrate autonomic nervous sytem. Parasympathetic nerves emerge cranially as pre-ganglionic fibres from oculomotor, facial, glossopharyngeal and vagus, and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic acetylcholine receptors. The parasympathetic system innervates, for example, salivary glands, thoracic and abdominal viscera, bladder and genitalia. BrendaTissueOBO parasympathetic part of autonomic division of nervous system BTO:0001833 parasympathetic nervous system BTO:0001834 Either of the pair of ganglionated longitudinal cords of the sympathetic nervous system of which one is situated on each side of the spinal column. BrendaTissueOBO sympathetic trunk BTO:0001834 sympathetic chain BTO:0001836 BrendaTissueOBO BTO:0001836 thymic epithelium BTO:0001842 The pallial cavity's nerve knots are called pleural ganglia. They innerve primarily the mantle or a snail. BrendaTissueOBO BTO:0001842 pleural ganglion BTO:0001844 The hard, calcareous substance covering the exposed portion of a tooth. BrendaTissueOBO enamel BTO:0001844 tooth enamel BTO:0001847 BrendaTissueOBO BTO:0001847 umbilical smooth muscle BTO:0001849 BrendaTissueOBO BTO:0001849 urinary bladder smooth muscle BTO:0001853 The innermost lining of a blood vessel. BrendaTissueOBO BTO:0001853 vascular endothelium BTO:0001854 BrendaTissueOBO BTO:0001854 vascular endothelial cell BTO:0001855 One of the paired, internal tubes leading from the venom glands to the paired openings near the tip of the aculeus. BrendaTissueOBO BTO:0001855 venom duct BTO:0001859 A horny projection on the skin usually of the extremities produced by proliferation of the skin papillae and caused by a papillomavirus. BrendaTissueOBO verruca vulgaris BTO:0001859 wart BTO:0001862 A nucleus forming the floor of the caudal part of the anterior prolongation of the lateral ventricle of the brain. BrendaTissueOBO accumbens nucleus colliculus of caudate nucleus nucleus accumbens septi BTO:0001862 nucleus accumbens BTO:0001863 A worm's body wall has two kinds of muscles that it uses to crawl. Circular muscles surround the worm's body and can make the body shrink or spread out. Longitudinal muscles run the length of the body and can shorten or lengthen the worm. Setae (bristles) prevent the worm from slipping. BrendaTissueOBO wall muscle BTO:0001863 body wall muscle BTO:0001864 Human caucasian pancreas adenocarcinoma cell line, established from a 62 years old caucasian female. BrendaTissueOBO As-PC1 cell AsPC1 cell BTO:0001864 AsPC-1 cell BTO:0001868 The most posterior promontory of each cerebral hemisphere; the apex of the occipital lobe. BrendaTissueOBO polus occipitalis cerebri BTO:0001868 occipital pole BTO:0001869 A small area of gray matter behind the olfactory trigone that is noted for receiving dopaminergic neurons from the substantia nigra and the reticular formation which have been implicated in schizoaffective disorders. BrendaTissueOBO BTO:0001869 olfactory tubercle BTO:0001873 Cuboidal epithelium covering the lens. BrendaTissueOBO ocular lens epithelium BTO:0001873 lens epithelium BTO:0001876 BrendaTissueOBO BTO:0001876 thyroid cell line BTO:0001882 BrendaTissueOBO ovarian adenocarcinoma cell line BTO:0001882 ovary adenocarcinoma cell line BTO:0001883 BrendaTissueOBO acute myelocytic leukemia cell line acute myelogenous leukemia cell line BTO:0001883 acute myeloid leukemia cell line BTO:0001886 The rudiment or commencement of a part or organ. BrendaTissueOBO BTO:0001886 primordium BTO:0001890 Human colon carcinoma cell line. RKO is a poorly differentiated colon carcinoma cell line developed by Michael Brattain. The RKO cell line is the parental cell line (isogenic) of RKO-E6 and RKO-A545-1. BrendaTissueOBO BTO:0001890 RKO cell BTO:0001893 The early trophozoite in the erythrocytic stage of the life cycle of hemosporian protozoa, which after Romanovsky staining has blue cytoplasm surrounding a clear zone with a red nucleus at one side, giving the cell the appearance of a signet ring. BrendaTissueOBO ring form signet ring BTO:0001893 ring stage BTO:0001906 The united head and thorax of an arachnid or higher crustacean. BrendaTissueOBO BTO:0001906 cephalothorax BTO:0001909 Mus musculus (mouse) brain; neuroblast; neuroblastoma cell line. The N1E-115 cell line was established in 1971 by T. Amano, E. Richelson, and M. Nirenberg by cloning the C-1300 spontaneous mouse neuroblastoma tumor, C-1300. BrendaTissueOBO NIE-115 cell BTO:0001909 N1E-115 cell BTO:0001910 Homo sapiens lung papillary adenocarcinoma cell line. The NCI-H441 cell line was derived in 1982 from the pericardial fluid of a patient with papillary adenocarcinoma of the lung. BrendaTissueOBO H-441 cell BTO:0001910 NCI-H441 cell BTO:0001911 BrendaTissueOBO BTO:0001911 lung adenocarcinoma cell line BTO:0001912 BrendaTissueOBO BTO:0001912 breast adenocarcinoma cell line BTO:0001913 BrendaTissueOBO BTO:0001913 colonic adenocarcinoma cell line BTO:0001914 BrendaTissueOBO BTO:0001914 colorectal adenocarcinoma cell line BTO:0001918 Colon carcinoma cell line. BrendaTissueOBO LIM 1863 cell BTO:0001918 LIM1863 cell BTO:0001921 An eye (as of an insect) made up of many separate visual units. BrendaTissueOBO Facettenauge Komplexauge zusammengesetztes Auge BTO:0001921 compound eye BTO:0001926 BrendaTissueOBO BTO:0001926 hybridoma cell line BTO:0001938 Human osteosarcoma cell line. BrendaTissueOBO U2 osteosarcoma cell U2OS cell BTO:0001938 U2-OS cell BTO:0001944 Human acute lymphoblastic leukemia cell line. BrendaTissueOBO BTO:0001944 H9 cell BTO:0001946 An atypical fibroblast combining the ultrastructural features of a fibroblast and a smooth muscle cell; it has a highly irregular nucleus, a large amount of rough endoplasmic reticulum, and a dense collection of myofilaments. BrendaTissueOBO smooth muscle-like cell BTO:0001946 myofibroblast BTO:0001948 Human, blood, leukemia, T cell line, clone E6.1. BrendaTissueOBO JURKAT E-61 cell BTO:0001948 JURKAT E-6.1 cell BTO:0001949 A convenient source of human endothelial cells are those that line the large vein in the umbilical cord which is usually discarded together with the placenta after childbirth. The cells can be removed as a fairly pure suspension by mild enzymatic treatment of the vein followed by some mechanical distraction and will grow relatively easily in culture, retaining their differentiated characteristics for several passages. BrendaTissueOBO HUVEC human umbilical vein endothelial cell BTO:0001949 HUVEC cell BTO:0001952 Human T cell leukemia cell line; established from the peripheral blood of a 14-year-old Japanese boy with ALL and thymoma at diagnosis in 1973. BrendaTissueOBO BTO:0001952 HPB-ALL cell BTO:0001953 Modified ependymal cell of the median eminence, having a body that lies near the third ventricle and sending out processes that extend to the capillary plexus of the portal circulation. Its function is unknown, but it may transport hormones from the cerebrospinal fluid into the portal circulation or from hypothalamic neurons to the cerebrospinal fluid. BrendaTissueOBO BTO:0001953 tanycyte BTO:0001957 Mouse embryo/fetus calvaria fibroblasts; established from the calvaria of an embryo/fetus C57BL/6 mouse; described to differentiate to osteoblasts and to produce collagen. BrendaTissueOBO BTO:0001957 MC3T3-E1 cell BTO:0001958 BrendaTissueOBO BTO:0001958 embryonic fibroblast cell line BTO:0001959 Human T cell leukemia; established from the peripheral blood of a 4-year-old girl with T cell acute lymphoblastic leukemia (T-ALL) in second relapse in 1977; cell lines BE-13 (DSM ACC 396) and PEER show identical DNA fingerprints and hence share common origin, presumably due to cross-ontamination; however, their diploid and tetraploid karyotypes indicative of earlier and later passage numbers, respectively, suggest that BE-13 is derived from PEER, rather than vice-versa. BrendaTissueOBO BTO:0001959 PEER cell BTO:0001963 BrendaTissueOBO BTO:0001963 aorta cell line BTO:0001964 BrendaTissueOBO BTO:0001964 aorta smooth muscle cell line BTO:0001966 BrendaTissueOBO BTO:0001966 cervical cell line BTO:0001967 BrendaTissueOBO cervical carcinoma cell line cervix cancer cell BTO:0001967 cervical cancer cell line BTO:0001973 BrendaTissueOBO BTO:0001973 vascular endothelial cell line BTO:0001974 Vascular endothelial cell line from human placenta. BrendaTissueOBO BTO:0001974 HPEC cell BTO:0001975 BrendaTissueOBO BTO:0001975 placental cell line BTO:0001976 Mus musculus (mouse) brain neuroblastoma cell line. Clone Neuro-2a was established by R.J. Klebe and F.H. Ruddle from a spontaneous tumor of a strain A albino mouse. BrendaTissueOBO N-2a cell N2a cell N2alpha cell NB-2a cell NB2a cell NEURO-2A cell Nb2a cell Neuro2A cell BTO:0001976 Neuro-2a cell BTO:0001979 A gland that secretes a slimy, chemically inert material. BrendaTissueOBO glandula mucosa muciparous gland BTO:0001979 mucous gland BTO:0001981 Fatty lubricant matter secreted by sebaceous glands of the skin. BrendaTissueOBO BTO:0001981 sebum BTO:0001996 BrendaTissueOBO BTO:0001996 endometrial cell line BTO:0001997 A small branch of an artery (a vessel that carries blood high in oxygen away from the heart to the body) leading to a capillary. The oxygenated hemoglobin (oxyhemoglobin) makes the blood in arteries and arterioles look bright red. BrendaTissueOBO BTO:0001997 arteriole BTO:0002008 An antigen-presenting cell is a cell that displays foreign antigen complex with major histocompatibility complex on its surface. BrendaTissueOBO APC cell accessory cell BTO:0002008 culture condition:antigen-presenting cell BTO:0002014 Mouse, C57BL/6, melanoma cell line. BrendaTissueOBO B16F10 cell BTO:0002014 B16-F10 cell BTO:0002018 A column of erectile tissue on either side (right and left), the two fusing to form the body of the clitoris. BrendaTissueOBO cavernous body of clitoris clitoral corpus cavernosum corpus cavernosum BTO:0002018 corpus cavernosum clitoridis BTO:0002022 BrendaTissueOBO BEC cell bronchial epithelium cell line BTO:0002022 bronchial epithelial cell line BTO:0002024 BrendaTissueOBO SCC cell line BTO:0002024 squamous cell carcinoma cell line BTO:0002029 A cell of a benign tumor made up of muscular elements. BrendaTissueOBO BTO:0002029 myoma cell BTO:0002030 BrendaTissueOBO NK cell line BTO:0002030 natural killer cell line BTO:0002035 Human glioma cell line. Morphology: glial; Species: human; Tumor: glioma. BrendaTissueOBO U-251 cell U-251MG cell U251 cell U251MG cell BTO:0002035 U-251 MG cell BTO:0002038 A cell that is characteristic of adult bone and is isolated in a lacuna of the bone substance. BrendaTissueOBO BTO:0002038 osteocyte BTO:0002042 A special type of cell that is a key regulator of the immune system, acting as a professional antigen-presenting cell, APC, capable of activating naive T cells and stimulating the growth and differentiation of B cells. Dendritic cells are found, for example, in the lymph nodes and spleen. As an APC, a dendritic cell can retain antigen for long periods on its surface, present the antigen to a T or B cell and so influence their behavior. BrendaTissueOBO interdigitating cell reticular cell veiled cell BTO:0002042 dendritic cell BTO:0002043 Human urinary bladder carcinoma (derivative of T-24); described as being spontaneously immortalized from the umbilical cord vein of a new-born Japanese boy in 1984; cells were described to have a high proliferative potential in the absence of any growth factors; however, DNA fingerprinting at DSMZ showed clearly that this cell line is in reality a derivative of human urinary bladder carcinoma cell line T-24. BrendaTissueOBO ECV 304 cell ECV304 cell BTO:0002043 ECV-304 cell BTO:0002045 A capillary tube; especially: any of the smallest blood vessels connecting arterioles with venules and forming networks throughout the body. BrendaTissueOBO BTO:0002045 capillary BTO:0002050 One of the cell's in the inner layer of the periosteum that forms osseous tissue. BrendaTissueOBO BTO:0002050 osteogenic cell BTO:0002051 A mesenchymal cell that differentiates into an osteoblast. BrendaTissueOBO osteoprogenitor cell BTO:0002051 preosteoblast BTO:0002052 BrendaTissueOBO BTO:0002052 osteogenic cell line BTO:0002057 A type of bronchogenic carcinoma made up of cuboidal or columnar cells in a discrete mass, usually at the periphery of the lungs. Most such tumors form glandular structures containing mucin, although a minority are solid and without mucin. Growth is slow, but there may be early invasion of blood and lymph vessels, giving rise to metastases while the primary lesion is still asymptomatic. BrendaTissueOBO pulmonary adenocarcinoma cell BTO:0002057 lung adenocarcinoma cell BTO:0002058 A general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma. BrendaTissueOBO NSCLC cell non-small cell carcinoma cell non-small cell lung carcinoma cell BTO:0002058 non-small cell lung cancer cell BTO:0002061 Any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma. BrendaTissueOBO BTO:0002061 bronchogenic carcinoma cell BTO:0002064 Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. BrendaTissueOBO BTO:0002064 stromal cell BTO:0002075 The epithelium which lines the subdural and subarachnoid spaces, the perilymphatic spaces in the inner ear, and the chamber of the eye. BrendaTissueOBO BTO:0002075 mesenchymal epithelium BTO:0002085 One of he various spaces in the eyeball. BrendaTissueOBO chamber of eye BTO:0002085 chamber of the eye BTO:0002086 That portion of the aqueous-containing space between the cornea and the lens which is bounded in front by the iris, and behind by the lens and ciliary zonule. BrendaTissueOBO camera oculi posterior camera posterior bulbi BTO:0002086 posterior chamber of the eye BTO:0002096 The portion of the passages of the respiratory system extending from the nares to the pharynx. It is divided into left and right halves by the nasal septum; its floor is the hard palate, which separates it from the oral cavity; and its lateral walls contain the nasal conchae and nasal meatus. BrendaTissueOBO cavitas nasalis cavitas nasi BTO:0002096 nasal cavity BTO:0002097 The space enclosed by the walls of the pharynx. BrendaTissueOBO cavitas pharyngis BTO:0002097 pharyngeal cavity BTO:0002098 The major portion of the middle ear (auris media), consisting of a narrow air-filled cavity in the temporal bone that contains the auditory ossicles. It communicates with the mastoid air cells and the mastoid antrum via the aditus and with the nasopharynx via the auditory tube. The middle ear and the tympanic cavity were formerly regarded as being synonymous. BrendaTissueOBO cavitas tympani cavitas tympanica tympanic cavity BTO:0002098 tympanum BTO:0002101 A malignant proliferation of plasma cells in bone marrow causing numerous tumors and characterized by the presence of abnormal proteins in the blood. BrendaTissueOBO plasma cell myeloma cell BTO:0002101 multiple myeloma cell BTO:0002107 The layer of areolar tissue situated beneath the mucous membrane. The layer of loose connective tissue between the lamina muscularis mucosae and the tunica muscularis in most parts of the digestive, respiratory, urinary, and genital tracts. BrendaTissueOBO submucous layer tela submucosa BTO:0002107 submucosa BTO:0002119 A small or secondary spike, specifically one of the small few-flowered bracted spikes that make up the compound inflorescence of a grass or sedge. BrendaTissueOBO BTO:0002119 spikelet BTO:0002120 The pyloric ceca (or digestive glands) and the cardiac stomach produce digestive enzymes in starfishes. Digested material is absorbed through the pyloric ceca for transport to the rest of the body. Each pyloric cecum extends the length of each arm. BrendaTissueOBO pyloric caecum BTO:0002120 pyloric cecum BTO:0002123 The primitive endoderm is the lower layer of the blastocyst that gives rise to fetal membranes. BrendaTissueOBO BTO:0002123 primitive endoderm BTO:0002126 Human caucasian glioblastoma-astrocytoma cell line; established from a 61-years-old caucasian male. BrendaTissueOBO U-373 MG cell U-373 cell U373MG cell BTO:0002126 U-373MG cell BTO:0002130 Human metastatic melanoma cell line. BrendaTissueOBO BTO:0002130 SK-MEL cell BTO:0002144 Lymphocytic leukemia cell line that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor, fatigue, appetite loss, bleeding, thrombocytopenia, granulocytopenia, bone and joint pain, and enlargement of the lymph nodes, liver, and spleen, and that occurs chiefly during childhood. BrendaTissueOBO ALL cell line BTO:0002144 acute lymphoblastic leukemia cell line BTO:0002146 Human thyroid anaplastic carcinoma cell line, established from the thyroid gland (right lobe) of a 70-year-old woman with thyroid anaplastic carcinoma in 1988; described as being tumorigenic in heterotransplanted nude mice. mgr 2010-09-28T04:03:16Z BrendaTissueOBO BTO:0002146 CAL-62 cell BTO:0002148 A thin membranous, sometimes alveolated sac in the dorsal portion of the abdominal cavity. Contains a varying mixture of gases, not identical to the composition of air. May be one, two or three chambered. May be connected to the gut by a tube, the ductus pneumaticus (then called physostomous) or unconnected (then called physoclistous). May function as one or more of:- hydrostatic organ, sound producing organ, sound receptor, respiratory organ. Found in Actinopterygii. Often lacking in bottom fishes. BrendaTissueOBO BTO:0002148 gas bladder BTO:0002157 Refers to skeletal elements which are formed in cartilage and which later ossify. Also called replacement bone because it gradually replaces the pre-existing cartilage. BrendaTissueOBO cartilaginous bone replacement bone BTO:0002157 endochondral bone BTO:0002158 A cell having a thickened cell wall and a small lumen. Hulle cells are associated with species of Aspergillus. They are associated with the cleistothecia of all ascogenous species of the Aspergillus nidulans group, abundantly occurring around it. BrendaTissueOBO hulle cell BTO:0002158 huelle cell BTO:0002178 Human Mammary Epithelial Cells (HMEpC) are derived from normal adult mammary glands. BrendaTissueOBO HMEC cell human mammary epithelial cell BTO:0002178 HMEpC cell BTO:0002180 The 184A1N4 and 184B5 cell lines are nontumorigenic cell lines derived from primary cultures of HMECs that were immortalized with benzo(a)pyrene. BrendaTissueOBO BTO:0002180 184B5 cell BTO:0002191 A bundle of nerve fibers (axons) having a common origin, termination, and function. BrendaTissueOBO fiber tract nerve fiber tract BTO:0002191 fibre tract BTO:0002195 BrendaTissueOBO VSMC cell line BTO:0002195 vascular smooth muscle cell line BTO:0002202 BrendaTissueOBO BTO:0002202 lung squamous cell carcinoma cell line BTO:0002204 The small cone-shaped process suspended in the mouth from the middle of the posterior border of the soft palate. XPMUser 2013-02-28T04:12:45Z BrendaTissueOBO uvula uvula palatina BTO:0002204 palatine uvula BTO:0002205 BrendaTissueOBO large cell carcinoma cell line BTO:0002205 large cell lung cancer cell line BTO:0002206 BrendaTissueOBO BTO:0002206 small cell lung cancer cell line BTO:0002207 BrendaTissueOBO H-460 cell H460 cell BTO:0002207 NCI-H460 cell BTO:0002219 A malignant adrenal cortical tumor that can cause endocrine disorders such as Cushing's syndrome or adrenogenital syndrome. BrendaTissueOBO ACC cell adrenal cortex cancer cell adrenal cortical carcinoma cell adrenocortical tumor cell carcinoma of adrenal cortex BTO:0002219 adrenocortical carcinoma cell BTO:0002222 A small modified leaf in a flower cluster. BrendaTissueOBO BTO:0002222 bract BTO:0002236 The somatic granulosa cells surrounding the oocyte are termed cumulus cells. BrendaTissueOBO cumulus cell BTO:0002236 ovarian cumulus cell BTO:0002240 A layer of the outer living cortical cells of plants that takes over the functions of the epidermis in roots lacking secondary thickening. BrendaTissueOBO plant hypodermis BTO:0002240 exodermis BTO:0002244 BrendaTissueOBO flower axis flower stem BTO:0002244 flower stalk BTO:0002245 BrendaTissueOBO BTO:0002245 foreskin fibroblast cell line BTO:0002246 The smaller and more medial part of the lentiform nucleus of the brain, separated from the putamen by the lateral medullary lamina. In official anatomic nomenclature, it is divided by the medial medullary lamina into two parts, lateral and medial, both of which have extensive connections with the corpus striatum, thalamus, and mesencephalon. The paleostriatum is the phylogenetically older part of the corpus striatum represented by the globus pallidus. BrendaTissueOBO pale body paleostriatum pallidum BTO:0002246 globus pallidus BTO:0002252 A biconvex mass of gray matter on the medial side of the junction of the internal capsule and the crus cerebri; its chief connections are with the globus pallidus. BrendaTissueOBO Luys' body nucleus of Luys nucleus subthalamicus BTO:0002252 subthalamic nucleus BTO:0002263 1. A hollow digestive organ, especially the stomach of certain insects or the gizzard of a bird. 2. The digestive cavity in the body of a sponge. BrendaTissueOBO BTO:0002263 ventriculus BTO:0002264 BrendaTissueOBO BTO:0002264 dried cell BTO:0002267 BrendaTissueOBO BTO:0002267 rhabdomyosarcoma cell line BTO:0002269 Human choriocarcinoma cell line; established from a human gestational choriocarcinoma which was taken at autopsy from a cerebral metastasis; serial sister cell line of cell line BEWO. BrendaTissueOBO JEG3 cell BTO:0002269 JEG-3 cell BTO:0002272 A protozoan cell that arises from the schizogony of a parent sporozoan and may enter either the asexual or sexual phase of the life cycle. BrendaTissueOBO BTO:0002272 merozoite BTO:0002278 BrendaTissueOBO BTO:0002278 macrophage cell line BTO:0002279 Mouse macrophage cell line. BrendaTissueOBO J774 cell BTO:0002279 J-774 cell BTO:0002282 Potorous tridactylis (potoroo) normal kidney cell line. BrendaTissueOBO NBL-5 cell Pt K2 cell PtK2 cell BTO:0002282 Pt-K2 cell BTO:0002285 BrendaTissueOBO primary granulosa cell line BTO:0002285 granulosa cell line BTO:0002290 BrendaTissueOBO BTO:0002290 primary cell line BTO:0002292 Long, slender, threadlike, whiplike extension of certain cells or unicellular organisms used mainly for movements (others for signal transduction). In bacteria, the flagella are helical filaments made up of the protein, flagellin, and rotate like screws. In eukaryotes, such as in cells of animals, plants and protists, they are made up of microtubules surrounded by the plasma membrane and enable the cells to move in a whip-like fashion. Some flagella are not used for movement but in sensation and signal transduction by various cell types, e.g. rod photoreceptor cells of the eye, olfactory receptor neurons of the nose, kinocilium in cochlea of the ear. XPMUser 2013-02-28T07:40:27Z BrendaTissueOBO BTO:0002292 flagellum BTO:0002295 A modified epithelial cell of the capsular epithelium of the renal glomerulus, having a small perikaryon and a number of primary and secondary footlike radiating processes (pedicels) that interdigitate with those of other podocytes and embrace the basal lamina of glomerular capillaries. BrendaTissueOBO renal glomerular podocyte BTO:0002295 podocyte BTO:0002299 A part of each pyramid of the medulla oblongata, between the ventrolateral and dorsolateral sulci; it is formed by an irregular mass of gray substance (nucleus olivaris caudalis) located just beneath its surface and is linked by fiber systems to the pons and cerebellum. BrendaTissueOBO inferior olive olivary body olivary nucleus BTO:0002299 oliva BTO:0002305 The anterior organ of a tapeworm used for attachment to host tissues. BrendaTissueOBO holdfast BTO:0002305 scolex BTO:0002308 A specialized type of epithelium that has contractile qualities. BrendaTissueOBO BTO:0002308 myoepithelium BTO:0002309 Modified smooth muscle cells, contractile in nature, believed to be of ectodermal origin, located around the secretory units of certain glands (salivary, mammary, sweat, and lacrimal glands) between the gland cells and basement membrane, having long dendritic interweaving cytoplasmic processes, and containing myofilaments. It is assumed that contraction of these cells functions to help express secretion from the gland. BrendaTissueOBO BTO:0002309 myoepithelial cell BTO:0002312 Having reached full natural growth or development: a mature cell. BrendaTissueOBO BTO:0002312 mature cell BTO:0002313 Not fully grown or developed. BrendaTissueOBO BTO:0002313 immature cell BTO:0002314 1. Glial cells that cluster about a neuron. 2. Free nuclei that accumulate around cells in certain diseases. 3. Elongated cells that are closely associated with a muscle fiber; they either are flattened against the fiber or occupy shallow depressions in its surface. BrendaTissueOBO BTO:0002314 satellite cell BTO:0002315 Cells that serve to provide support and protection and perhaps contribute to the nutrition of principal or other cells of certain organs; such cells are found in the labyrinth of the inner ear, organ of Corti, olfactory epithelium, taste buds, and seminiferous tubules (Sertoli's cells). BrendaTissueOBO sustentacular cell BTO:0002315 supporting cell BTO:0002316 Any cell having a star-shaped appearance produced by numerous processes that extend in different directions, such as the Kupffer cells in the liver, astrocytes, and granule cells in the granular layers of the cerebral and cerebellar cortices. BrendaTissueOBO BTO:0002316 stellate cell BTO:0002320 Cardiac muscle fibers contain one or sometimes two nuclei and myofibrils and are separated from one another by an intercalated disk; although striated, cardiac muscle fibers branch to form an interlacing network. BrendaTissueOBO cardiac muscle cell cardiac myocyte cardiomyocyte BTO:0002320 cardiac muscle fiber BTO:0002322 BrendaTissueOBO BTO:0002322 cell property BTO:0002323 An ordinary, or simple, sweat gland; they are of the merocrine type, unbranched, coiled, tubular glands that are distributed over almost all of the body surface, and promote cooling by evaporation of their secretion. BrendaTissueOBO eccrine gland BTO:0002323 eccrine sweat gland BTO:0002324 One in which the secretory cells maintain their integrity throughout the secretory cycle. BrendaTissueOBO BTO:0002324 merocrine gland BTO:0002327 The outermost rows of cells in a cross section of the stem. BrendaTissueOBO BTO:0002327 stem cortex BTO:0002328 The pair of closely united ventral longitudinal nerves with their segmental ganglia that is characteristic of many elongate invertebrates (as earthworms). BrendaTissueOBO ventral cord BTO:0002328 ventral nerve cord BTO:0002330 A highly vascular layer of connective tissue under the basement membrane lining a layer of epithelium. BrendaTissueOBO tunica propria BTO:0002330 lamina propria BTO:0002334 BrendaTissueOBO RPE cell RPE cell line BTO:0002334 retinal pigment epithelium cell line BTO:0002342 A small, comma-shaped form of Toxoplasma gondii, found in clusters enclosed by an irregular wall (pseudocyst) in the tissues, chiefly muscles and the brain, in chronic (latent) toxoplasmosis; considered to be the slow-growing form. BrendaTissueOBO BTO:0002342 bradyzoite BTO:0002343 Any of the seven bones of the tarsus. The seven bones constituting the articulation between the foot and the leg-the talus, calcaneus, and navicular, in the proximal row; and the cuboid and the lateral, intermediate, and medial cuneiform bones, in the distal row. BrendaTissueOBO bony tarsus ossa tarsalia ossa tarsi tarsal tarsus osseus BTO:0002343 tarsal bone BTO:0002347 Any of the five bones extending from the tarsus to the phalanges of the toes, being numbered in the same sequence from the most medial to the most lateral. BrendaTissueOBO metatarsal ossa metatarsalia ossa metatarsi BTO:0002347 metatarsal bone BTO:0002348 1. Any of the five digits of the foot. 2. The anterior part of a horse's hoof. BrendaTissueOBO digitipedis hindlimb digit BTO:0002348 toe BTO:0002349 The first digit of the foot. BrendaTissueOBO digitus primus (I) pedis great toe BTO:0002349 hallux BTO:0002353 The fifth, and smallest, digit of the foot. BrendaTissueOBO digitus quintus (V) pedis little toe BTO:0002353 digitum minimus pedis BTO:0002354 The highest of the tarsal bones and the one that articulates with the tibia and fibula to form the ankle joint. BrendaTissueOBO ankle ankle bone astragaloid bone astragalus os tarsi tibiale BTO:0002354 talus BTO:0002355 The irregular quadrangular bone at the back of the tarsus. BrendaTissueOBO calcaneum calcaneus heel bone os calcis os tarsi fibulare BTO:0002355 calcaneal bone BTO:0002362 The main excretory duct of the pancreas, which usually unites with the common bile duct before entering the duodenum at the major duodenal papilla. BrendaTissueOBO canal of Wirsung duct of Wirsung hepaticopancreatic duct BTO:0002362 pancreatic duct BTO:0002363 Carcinoma that arises from the pancreatic ducts. It accounts for the majority of cancers derived from the pancreas. BrendaTissueOBO PDC cell duct cell carcinoma cell of the pancreas duct-cell carcinoma cell of the pancreas ductal carcinoma of the pancreas pancreas duct-cell carcinoma cell pancreatic duct cell carcinoma cell BTO:0002363 pancreatic ductal carcinoma cell BTO:0002368 Rat Fischer cell line; established from a female rat embryo /whole fetus. Mother clone of 3Y1 series, fibroblast-like. BrendaTissueOBO 3Y1 cell BTO:0002368 3Y1-B clone 1 cell BTO:0002372 A rare type of neuroepithelial tumor, usually found in the brain or retina, composed of primitive neuroepithelial cells lining the tubular spaces. BrendaTissueOBO neurocytoma cell neuroepithelial tumor cell BTO:0002372 neuroepithelioma cell BTO:0002380 BrendaTissueOBO BTO:0002380 gastric adenocarcinoma cell line BTO:0002383 Well differentiated human gastric adenocarcinoma cell line. BrendaTissueOBO MKN74 cell BTO:0002383 MKN-74 cell BTO:0002392 Human gastric cancer cell line. BrendaTissueOBO SGC7901 cell BTO:0002392 SGC-7901 cell BTO:0002397 Normal prostatic epithelium is composed of basal and luminal cells. BrendaTissueOBO prostate epithelium prostatic epithelium BTO:0002397 prostate gland epithelium BTO:0002398 BrendaTissueOBO BTO:0002398 prostate epithelium cell line BTO:0002399 Human normal prostate epithelium cell line immortalized with SV40. BrendaTissueOBO PNT2 cell BTO:0002399 PNT-2 cell BTO:0002404 Human breast cancer cell line; established from a 55 year-old human female. BrendaTissueOBO YMB1 cell BTO:0002404 YMB-1 cell BTO:0002405 Human eosinophilic leukaemia cell line. BrendaTissueOBO BTO:0002405 EoL-1 cell BTO:0002406 A form of granulocytic leukemia cell line characterized by abnormal numbers of or a predomination of eosinophilic granulocytes in the tissues and blood. BrendaTissueOBO BTO:0002406 eosinophilic leukemia cell line BTO:0002410 A poorly differentiated, highly malignant, epithelial neoplasm containing numerous very large, multinucleated tumor cells, such as occurs in the lungs. BrendaTissueOBO BTO:0002410 giant cell carcinoma cell BTO:0002414 Cloned PG cell subline. BrendaTissueOBO PGCL3 cell BTO:0002414 PG-CL3 cell BTO:0002417 A T-cell that participates in an immune response by recognizing a foreign antigen and secreting lymphokines to activate T cell and B cell proliferation, that usually carries CD4 molecular markers on its cell surface, and that is reduced to 20 percent or less of normal numbers in AIDS. Marion 2010-01-28T08:36:32Z BrendaTissueOBO CD4 cell T helper cell T4 cell helper T cell helper T lymphocyte helper T-cell helper cell helper lymphocyte BTO:0002417 helper T-lymphocyte BTO:0002420 A cell of leukemia characterized by the proliferation of monocytes and monoblasts in the blood. BrendaTissueOBO histiocytic leukaemia cell histiocytic leukemia cell monoblastic leukaemia cell monoblastic leukemia cell BTO:0002420 monocytic leukemia cell BTO:0002424 BrendaTissueOBO BTO:0002424 mesothelioma cell line BTO:0002425 Human mesothelioma cell line; established from the pleural effusion of a 62-year-old Caucasian man with mesothelioma (malignant biphasic) who did not have any prior therapy. BrendaTissueOBO 211H cell MSTO-211 H cell BTO:0002425 MSTO-211H cell BTO:0002426 Chinese hamster ovary cells expressing polyoma LT antigen. BrendaTissueOBO BTO:0002426 CHOP cell BTO:0002435 BrendaTissueOBO BTO:0002435 colorectal mucosa BTO:0002436 That part of the enteric plexus within the tunica muscularis. BrendaTissueOBO Auerbach's plexus plexus myentericus BTO:0002436 myenteric plexus BTO:0002439 BrendaTissueOBO BTO:0002439 genital mucosa BTO:0002449 BrendaTissueOBO BTO:0002449 hypothalamic nucleus BTO:0002477 XPMUser 2011-02-23T10:21:01Z BrendaTissueOBO caecal epithelium BTO:0002477 cecal epithelium BTO:0002480 Organisms as Riftia pachyptila end with a deep red fan-like structure (plume) which extends into the water and which absorbs H2S and O2 for the bacteria, and also absorbs CO2 for use as synthetic raw material. An animal structure having a main shaft bearing many hairs or filamentous parts; especially: a full bushy tail. BrendaTissueOBO BTO:0002480 plume BTO:0002482 A basophil of the adenohypophysis whose granules secrete follicle-stimulating hormone and luteinizing hormone. Called also delta basophil, delta cell, and gonadotrope or gonadotropic cell. BrendaTissueOBO delta basophil delta cell gonadotrope cell gonadotropic BTO:0002482 gonadotrophic cell BTO:0002484 An elongated epithelial cell. BrendaTissueOBO columnar epithelial cell BTO:0002484 columnar cell BTO:0002485 The ear-shaped appendage of either atrium of the heart. BrendaTissueOBO atrial auricula auricula atrialis BTO:0002485 atrial appendage BTO:0002502 Pertaining or relating to protozoa of the order Kinetoplastida. BrendaTissueOBO BTO:0002502 kinetoplastid BTO:0002503 Any individual of the Protozoa. BrendaTissueOBO protozoal form BTO:0002503 protozoan form BTO:0002504 BrendaTissueOBO BTO:0002504 T-lymphoblastic leukemia cell line BTO:0002505 An aggressive (rapidly progressing) type of non-Hodgkins lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver. BrendaTissueOBO ALCL cell BTO:0002505 anaplastic large cell lymphoma cell BTO:0002506 Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. BrendaTissueOBO BTO:0002506 enteric nervous system BTO:0002507 The enteric, parasympathetic, and sympathetic nervous systems taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the central nervous system, especially the hypothalamus and the solitary nucleus, which receive information relayed from VISCERAL AFFERENTS; these and related central and sensory structures are sometimes (but not here) considered to be part of the autonomic nervous system itself. BrendaTissueOBO BTO:0002507 autonomic nervous system BTO:0002513 A malignant primary bone tumour that arises most commonly in the first three decades of life. BrendaTissueOBO ETB cell EWS cell Ewing sarcoma cell Ewing tumor cell Ewing's sarcoma of bone Ewing's tumor of bone BTO:0002513 Ewing's sarcoma cell BTO:0002515 BrendaTissueOBO brain cortical cell line cerebral cortex cell line BTO:0002515 brain cortex cell line BTO:0002517 BrendaTissueOBO BTO:0002517 follicular lymphoma cell line BTO:0002552 Homo sapiens (human) lung carcinoma cell line, non-small cell lung cancer; derived from metastatic site: lymph node. BrendaTissueOBO H-1299 cell H1299 cell BTO:0002552 NCI-H1299 cell BTO:0002553 BrendaTissueOBO NSCLC cell line non small cell lung cancer cell line BTO:0002553 non-small cell lung cancer cell line BTO:0002572 Mouse embryonic fibroblast cell line. BrendaTissueOBO BTO:0002572 MEF cell BTO:0002573 Human embryonal carcinoma (teratocarcinoma). NTERA-2 was cloned from cell line TERA-2 which was derived from a metastatic teratocarcinoma of a 22-year-old Caucasian male. BrendaTissueOBO BTO:0002573 TERA-2 cell BTO:0002575 Human ovary carcinoma cell line. BrendaTissueOBO IGROV1 cell BTO:0002575 IGROV-1 cell BTO:0002576 The UMR-106 cell line is a clonal derivative of a transplantable rat osteosarcoma that had been induced by injection of radiophosphorous (32P). BrendaTissueOBO BTO:0002576 UMR-106 cell BTO:0002580 BrendaTissueOBO chronic myelogenous leukemia cell line BTO:0002580 chronic myeloid leukemia cell line BTO:0002581 Human chronic myeloid leukemia in megakaryocytic blast crisis established from the bone marrow of a 55-year-old man with chronic myeloid leukemia (CML) in megakaryocytic blast crisis in 1983. BrendaTissueOBO BTO:0002581 MEG-01 cell BTO:0002584 Hela cells containing human papilloma viral (HPV) DNA sequences. BrendaTissueOBO WRL 68 cell WRL68 cell BTO:0002584 WRL-68 cell BTO:0002587 Pluripotent adrenocortical carcinoma cell line. BrendaTissueOBO H-295 cell H295 cell BTO:0002587 NCI-H295 cell BTO:0002589 Human hepatocarcinoma cell line. BrendaTissueOBO H7721 cell BTO:0002589 H-7721 cell BTO:0002590 Human ovarian carcinoma cell line. BrendaTissueOBO BTO:0002590 HEY cell BTO:0002595 BrendaTissueOBO BTO:0002595 leiomyosarcoma cell line BTO:0002597 Human gastric adenocarcinoma cell line established from a 72-year-old male. BrendaTissueOBO NUGC3 cell BTO:0002597 NUGC-3 cell BTO:0002600 BrendaTissueOBO BTO:0002600 astrocyte cell line BTO:0002605 Human rhabdomyosarcoma cell line. In the original publication and in the ATCC catalogue this cell line is described as medulloblastoma; recent studies and the characterization carried out at the DSMZ indicated that TE-671 are muscle cells, most likely identical to the rhabdomyosarcoma cell line RD (also known as TE32 or 130T). BrendaTissueOBO TE671 cell BTO:0002605 TE-671 cell BTO:0002606 As glia they build the delicate network of branched cells and fibers that supports the tissue of the central nervous system. Marion 2010-01-28T08:55:00Z BrendaTissueOBO glia cell neuroglia cell neuroglial cell BTO:0002606 glial cell BTO:0002608 A specialized part of the olfactory system located anteriorly in the nasal cavity within the nasal septum. Chemosensitive cells of the vomeronasal organ project via the vomeronasal nerve to the accessory olfactory bulb. The primary function of this organ appears to be in sensing pheromones which regulate reproductive and other social behaviors. While the structure has been thought absent in higher primate adults, data now suggests it may be present in adult humans. BrendaTissueOBO Jacobson's organ organum vomeronasale BTO:0002608 vomeronasal organ BTO:0002610 A temporary cytoplasmic extrusion by means of which an ameba or other ameboid organism or cell moves about or engulfs food. BrendaTissueOBO BTO:0002610 pseudopodium BTO:0002612 A slender filamentous pseudopodium with a pointed end, branched or unbranched, consisting mostly of ectoplasm. BrendaTissueOBO BTO:0002612 filopodium BTO:0002617 Pathological nodule in the thyroid gland, often filled with colloid; some are indicative of adenoma or carcinoma. BrendaTissueOBO BTO:0002617 thyroid nodule BTO:0002626 A small vein, especially one joining capillaries to larger veins. BrendaTissueOBO BTO:0002626 venule BTO:0002627 BrendaTissueOBO BTO:0002627 T-lymphoblastoma cell BTO:0002628 BrendaTissueOBO BTO:0002628 B-lymphoblastoma cell BTO:0002629 BrendaTissueOBO T-cell lymphoblastoid cell line BTO:0002629 T-lymphoblastoid cell line BTO:0002632 BrendaTissueOBO BTO:0002632 larval cell line BTO:0002637 BrendaTissueOBO airway epithelium cell line BTO:0002637 respiratory epithelium cell line BTO:0002639 Mouse neuroblastoma cell line established from a A/Jax mouse strain with neuroblastoma C1300. Cells were described to be aneuploid and to contain high specific activity of choline acetyltransferase. BrendaTissueOBO NS-20Y cell NS20-Y cell BTO:0002639 NS20Y cell BTO:0002651 An area in the rhinencephalon, pear-shaped in some species but not in humans; it includes the lateral olfactory process or gyrus, the limen insulae, the uncus, and part of the parahippocampal gyrus; subdivided into the prepiriform area, the periamygdaloid area, and the entorhinal area. BrendaTissueOBO piriform cortex piriform lobe pyriform area pyriform lobe BTO:0002651 piriform area BTO:0002655 The final juvenile stage. It is the only time in a lobster's life that it can swim forward. BrendaTissueOBO postlarva stage BTO:0002655 postlarva BTO:0002658 BrendaTissueOBO BTO:0002658 collecting duct cell line BTO:0002659 BrendaTissueOBO embryonic cerebral cortex cell line BTO:0002659 embryonic brain cortex cell line BTO:0002660 The inflorescence stalk is the main stem of the inflorescence that connects to the plant. BrendaTissueOBO inflorescence stem BTO:0002660 inflorescence stalk BTO:0002664 Immortilized embryonic brain cortex cell line overexpressing the human tau protein. BrendaTissueOBO BTO:0002664 HTAU cell BTO:0002666 Adult stem cells are undifferentiated cells that reproduce daily to provide certain specialized cells. Until recently it was thought that each of these cells could produce just one particular type of cell. This is called differentiation. However in the past few years, evidence has been gathered of stem cells that can transform into several different forms. BrendaTissueOBO adulte Stammzelle multipotent adult progenitor cell somatic stem cell BTO:0002666 adult stem cell BTO:0002669 Stem cells found in the peripheral blood rather than the bone marrow; their numbers can be artificially increased by exposure to hematopoietic growth factors so that they can be extracted before myeloablative chemotherapy and later infused as an autologous bone marrow transplantation. BrendaTissueOBO PBPC peripheral blood progenitor cell periphere Blutstammzelle BTO:0002669 peripheral blood stem cell BTO:0002678 Either of the testicular veins. BrendaTissueOBO spermatic vein vena tesicularis BTO:0002678 testicular vein BTO:0002681 BrendaTissueOBO BTO:0002681 renal vein BTO:0002682 The venous trunk for the lower extremities and for the pelvic and abdominal viscera; it begins at the level of the fifth lumbar vertebra by union of the common iliac veins, passes upward on the right of the aorta, and empties into the right atrium of the heart. BrendaTissueOBO vena cava inferior BTO:0002682 inferior vena cava BTO:0002688 A cell of the vascular system. BrendaTissueOBO BTO:0002688 vascular cell BTO:0002690 A thin usually resistant layer of microorganisms (as bacteria) that form on and coat various surfaces (as of water pipes and catheters). BrendaTissueOBO BTO:0002690 biofilm BTO:0002694 A benign tumor derived from smooth muscle, most commonly of the uterus. BrendaTissueOBO fibroid cell fibroid tumor cell BTO:0002694 leiomyoma cell BTO:0002708 Immortalized female rat hypothalamus gonadotropin-releasing hormone (GnRH) neurons. BrendaTissueOBO BTO:0002708 GT1-7 cell BTO:0002709 Head and neck squamous cell carcinoma. BrendaTissueOBO HNSCC cell neck squamous cell carcinoma cell line BTO:0002709 head and neck squamous cell carcinoma cell line BTO:0002715 Human neck squamous cell carcinoma cell line. BrendaTissueOBO SCC-38 cell SCC38 cell UMSCC-38 cell UMSCC38 cell BTO:0002715 UM-SCC-38 cell BTO:0002719 Primary effusion lymphoma (PEL) is a peculiar type of B cell non-Hodgkin lymphoma (NHL) that has been recently recognized as an individual clinico-pathologic category based on the consistent infection of the tumor clone by human herpesvirus type-8 (HHV-8) and the distinctiveness of its clinical and biologic features. Although immunogenotypic studies have confirmed that PEL belongs in all cases to the B cell lineage, the overwhelming majority of cases exhibit a non-B, non-T (ie indeterminate) phenotype, lacking expression of surface immunoglobulins and common B cell associated antigens. BrendaTissueOBO BCBL cell PEL cell line body cavity based lymphoma cell line body cavity-based lymphoma cell BTO:0002719 primary effusion lymphoma cell line BTO:0002729 BrendaTissueOBO OSC cell BTO:0002729 ovarian serous carcinoma cell BTO:0002730 Uterine serous carcinoma is an uncommon form of endometrial cancer that typically arises in postmenopausal women. BrendaTissueOBO UPSC cell USC cell uterine papillary serous carcinoma cell uterine serous adenocarcinoma cell BTO:0002730 uterine serous carcinoma cell BTO:0002731 Cell that will give rise to erythrocytes. BrendaTissueOBO BTO:0002731 erythroid cell BTO:0002733 BrendaTissueOBO BTO:0002733 embryonic kidney cell line BTO:0002738 Typical barnacles, common name of the sedentary crustacean marine animals constituting the subclass Cirripedia, attach to the substrate by means of an exceedingly adhesive cement, produced by a cement gland, and secrete a shell, or carapace, of calcareous (limestone) plates, around themselves. BrendaTissueOBO cementary gland BTO:0002738 cement gland BTO:0002745 Human pancreas adenocarcinoma cell line; established from the tumor of a 56-year-old Caucasian man with pancreas adenocarcinoma in 1975. BrendaTissueOBO BTO:0002745 CAPAN-2 cell BTO:0002747 Hamster pancreatic cancer cell line. BrendaTissueOBO BTO:0002747 PC-1 cell BTO:0002767 Rat pituitary tumor cell line; established from a pituitary tumor of a 7-month-old female Wistar/Furth rat. Cell line GH4 was subcloned in order to obtain a cell line secreting high amounts of growth hormones. BrendaTissueOBO GH4C1 cell BTO:0002767 GH4-C1 cell BTO:0002768 BrendaTissueOBO BTO:0002768 mammary epithelial cell line BTO:0002773 Cancer of the salivary gland is a malignant tumor of the tissues that produce saliva. BrendaTissueOBO salivary gland tumor cell salivary gland tumour cell BTO:0002773 salivary gland cancer cell BTO:0002774 A plaque consisting of tangles of amyloid protein in nervous tissue (a pathological mark of Alzheimer's disease). BrendaTissueOBO BTO:0002774 amyloid plaque BTO:0002775 The ANA-1 immortalized murine macrophage cell line was established by infecting the normal bone marrow of C57BL/6 mice with the murine recombinant 52 retrovirus (expressing the v-raf and v-myc oncogenes). BrendaTissueOBO BTO:0002775 ANA-1 cell BTO:0002781 One of the large veins which return blood from the intestines. BrendaTissueOBO BTO:0002781 mesenteric vein BTO:0002790 BrendaTissueOBO phloem parenchyma BTO:0002790 phloem parenchyma cell BTO:0002807 The prefrontal cortex is the anterior part of the frontal lobes of the brain, lying in front of the motor and premotor areas. BrendaTissueOBO prefrontal association complex BTO:0002807 prefrontal cortex BTO:0002808 Mouse melanoma cell line. BrendaTissueOBO B16/BL6 cell BTO:0002808 B16-BL6 cell BTO:0002813 The fetal ligament attached to the inferior end of the epididymis and testis and, at its other end, to the bottom of the scrotum; it is present during, and is thought to guide, the descent of the testis into the scrotum and then atrophies. BrendaTissueOBO Hunter's gubernaculum BTO:0002813 gubernaculum testis BTO:0002817 BrendaTissueOBO BTO:0002817 esophageal cancer cell line BTO:0002820 A rare slow-growing type of brain tumor that begins in cells called oligodendrocytes, which provide support and nourishment for cells that transmit nerve impulses. BrendaTissueOBO oligodendroglial tumor cell line BTO:0002820 oligodendroglioma cell line BTO:0002845 Channel conveying the milk secreted by the lobes of the breast to and through the nipples. BrendaTissueOBO ductus lactiferi galactophorous tubule lactiferous duct lactiferous tubule BTO:0002845 mammary duct BTO:0002850 Lutein cell derived from the theca interna. BrendaTissueOBO paraluteal cell paralutein cell theca-lutein cell BTO:0002850 theca cell BTO:0002858 That part of the brain substance underlying the cerebral cortex. BrendaTissueOBO subcortex BTO:0002858 cerebral subcortex BTO:0002860 The mucous coat (membrane) lining the oral cavity. BrendaTissueOBO tunica mucosa oris BTO:0002860 oral mucosa BTO:0002861 Squamous cell carcinoma is the most common type of esophageal cancer, accounting for 95% of all esophageal cancers worldwide. BrendaTissueOBO ESCC cell BTO:0002861 esophageal squamous cell carcinoma cell BTO:0002868 BrendaTissueOBO BTO:0002868 bladder transitional cell carcinoma cell line BTO:0002869 BrendaTissueOBO BTO:0002869 transitional cell carcinoma cell line BTO:0002871 BrendaTissueOBO BTO:0002871 embryonic brain cell line BTO:0002872 BrendaTissueOBO BTO:0002872 embryonic hippocampal cell line BTO:0002874 This line was derived from the a 5-bromo-2'-deoxyuridine resistant strain of the Fischer rat fibroblast 3T3 like cell line, Rat1. Rat2 lacks detectable nuclear thymidine kinase, is highly transfectable by exogenous DNA and is phenotypically normal. BrendaTissueOBO Rat2 cell BTO:0002874 Rat-2 cell BTO:0002878 BrendaTissueOBO B lymphoblastoid cell BTO:0002878 B-lymphoblastoid cell BTO:0002881 Neural stem cells are the multipotent stem cells that generate nerve cells. However, since the early 1990s, neural stem cells have been isolated from the adult brain as well as fetal brain tissues. Stem cells in the adult brain are found in the areas called the subventricular zone and the ventricle zone. Another location of brain stem cells occurs in the hippocampus, a special structure of the cerebral cortex related to memory function. Stem cells isolated from these areas are able to divide and to give rise to nerve cells and neuron-supporting cell types in culture. BrendaTissueOBO Nerven-Stammzelle neural precursor cell neural progenitor cell neural stem progenitor cell neurale Stammzelle neuronal precursor cell neuronal stem cell BTO:0002881 neural stem cell BTO:0002882 Mouse bone marrow cell line; established from long-term bone marrow cultures of C3H/HeJ mice infected with the Friend murine leukemia virus. BrendaTissueOBO BTO:0002882 32D cell BTO:0002883 Mouse bone marrow cell line. BrendaTissueOBO 32D CL3 cell 32D.cl3 cell 32D/cl3 cell 32Dcl3 cell BTO:0002883 32D clone3 cell BTO:0002886 BrendaTissueOBO kidney epithelium cell line BTO:0002886 renal epithelium cell line BTO:0002887 Mouse, C3H/An; tissue: areolar and adipose; derived from NCTC clone 929. BrendaTissueOBO A9 cell BTO:0002887 A-9 cell BTO:0002891 BrendaTissueOBO BTO:0002891 neural stem cell line BTO:0002896 Murine embryonic stem cell line. BrendaTissueOBO HM-1 cell BTO:0002896 HM-1 ES cell BTO:0002901 BrendaTissueOBO BTO:0002901 neural crest cell line BTO:0002904 BrendaTissueOBO non-Hodgkin's lymphoma cell line non-Hodgkins lymphoma cell BTO:0002904 non-Hodgkin lymphoma cell line BTO:0002906 A subline of the PLC/PRF/5 cell line. BrendaTissueOBO NPLC cell BTO:0002906 NPLC/PRF/5 cell BTO:0002912 BrendaTissueOBO BTO:0002912 neuroepithelioma cell line BTO:0002913 BrendaTissueOBO BTO:0002913 epithelioma cell line BTO:0002914 Human neuroblastoma cell line; established from the supraorbital metastasis of a neuroblastoma of a 14-year-old girl in 1971; although described in the original paper as neuroblastoma, SK-N-MC is now widely regarded as having originated from the morphologically similar Askin's tumor related to Ewing's sarcoma. BrendaTissueOBO BTO:0002914 SK-N-MC cell BTO:0002919 BrendaTissueOBO BTO:0002919 retinoblastoma cell line BTO:0002920 Human retinoblastoma cell line; established from the primary tumor (right eye) of a 2-year-old Caucasian girl in 1971. BrendaTissueOBO Y79 cell BTO:0002920 Y-79 cell BTO:0002922 A normal cell of the bronchial epithelium. BrendaTissueOBO BTO:0002922 bronchial epithelial cell BTO:0002923 Epithelial cells were isolated from normal human bronchial epithelium obtained from autopsy of non-cancerous individuals. BrendaTissueOBO B2B cell BEAS 2B cell BEAS2B cell BTO:0002923 BEAS-2B cell BTO:0002928 BrendaTissueOBO adulte Stammzelllinie BTO:0002928 adult stem cell line BTO:0002938 Rat nervous tissue oligodendroglioma cell line. 33B is a N-Ethyl-N-nitrosourea-induced neural tumour cell line derived from 17th in vivo passage of TR33B. BrendaTissueOBO BTO:0002938 33B cell BTO:0002951 Human melanoma cell line. BrendaTissueOBO 624 mel cell 624mel cell BTO:0002951 624 cell BTO:0002965 Human melanoma cell line. BrendaTissueOBO M10 cell BTO:0002965 M10 melanoma cell BTO:0002967 Human cell line established from a metastatic melanoma. BrendaTissueOBO SK-MEL37 cell BTO:0002967 SK-MEL-37 cell BTO:0002974 Human embryonic kidney cell line, expressing EBNA. BrendaTissueOBO 293 EBNA cell 293-EBNA cell 293/EBNA cell EBNA-293 cell HEK 293 EBNA cell HEK-293E cell HEK293EBNA cell BTO:0002974 HEK-293-EBNA cell BTO:0002975 Human skin melanoma cell line, established from a 43 years adult caucasian male. BrendaTissueOBO A2058 cell BTO:0002975 A-2058 cell BTO:0002979 Material that is secreted as a result of the activity of a gland; this activity may range from separating a specific substance of the blood to the elaboration of a new chemical substance. BrendaTissueOBO BTO:0002979 secretion BTO:0002990 A peptic ulcer of the gastric mucosa. BrendaTissueOBO BTO:0002990 gastric ulcer BTO:0002991 Epithelium composed of secretory cells. BrendaTissueOBO BTO:0002991 glandular epithelium BTO:0002999 Human prostate carcinoma cell line; derived from a human prostate carcinoma xenograft (CWR22R) that was serially propagated in nude mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft. BrendaTissueOBO 22Rv1 cell CWR22-Rv1 cell CWR22R-V1 cell CWR22Rv1 cell BTO:0002999 22Rv-1 cell BTO:0003000 Human Burkitt lymphoma cell line; established from the maxilla tumor lymph node of a 9-year-old black girl with Burkitt lymphoma in 1964; cells were described to be EBV-positive. BrendaTissueOBO EB1 cell BTO:0003000 EB-1 cell BTO:0003001 Human lung squamous cell carcinoma cell line; established from a 68 year old male. BrendaTissueOBO EBC1 cell BTO:0003001 EBC-1 cell BTO:0003009 Non-small cell lung cancer cell line. BrendaTissueOBO H-1703 cell H1703 cell BTO:0003009 NCI-H1703 cell BTO:0003015 An irregular yellowish depression on the retina, about 3 degrees wide, lateral to and slightly below the optic disk; it is the site of absorption of short wavelengths of light, and it is thought that its variation in size, shape, and coloring may be related to variant types of color vision. BrendaTissueOBO macula flava retinae macula retinae BTO:0003015 macula lutea BTO:0003016 Non-small cell lung cancer cell line. BrendaTissueOBO SW1573 cell BTO:0003016 SW-1573 cell BTO:0003019 Small cell lung cancer cell line. BrendaTissueOBO H-345 cell H345 cell BTO:0003019 NCI-H345 cell BTO:0003021 Small cell lung cancer cell line. BrendaTissueOBO H-187 cell H187 cell BTO:0003021 NCI-H187 cell BTO:0003023 Small cell lung cancer cell line. BrendaTissueOBO H-510 cell H510 cell BTO:0003023 NCI-H510 cell BTO:0003029 Non-small cell lung cancer cell line. BrendaTissueOBO SK LU 1 cell SK-LU-1 cell SKLU1 cell BTO:0003029 SKLU-1 cell BTO:0003031 HCA-7 cell line was originally derived from human colonic carcinoma. BrendaTissueOBO BTO:0003031 HCA-7 cell BTO:0003034 Human embryonic lung fibroblast cell line. BrendaTissueOBO hELF cell BTO:0003034 HELF cell BTO:0003036 BrendaTissueOBO BTO:0003036 hippocampal cell line BTO:0003037 Mouse hippocampal cell line. BrendaTissueOBO HT22 cell BTO:0003037 HT-22 cell BTO:0003038 This is a substrain of HEC-1-A. Marion 2010-01-29T10:24:37Z BrendaTissueOBO HEC-1B cell HEC1B cell BTO:0003038 HEC-1-B cell BTO:0003039 A group of hypodermal cells in worms that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail. BrendaTissueOBO seam cell seam hypodermal cell BTO:0003039 hypodermal seam cell BTO:0003040 BrendaTissueOBO endometrial adenocarcinoma cell line BTO:0003040 uterine adenocarcinoma cell line BTO:0003041 The cell line Ishikawa was established from an endometrial adenocarcinoma from a 39-year-old Asian woman. BrendaTissueOBO BTO:0003041 Ishikawa cell BTO:0003045 A tumor growing from a nerve or made up largely of nerve cells and nerve fibers. BrendaTissueOBO nerve cancer cell nerve tumor cell BTO:0003045 neuroma cell BTO:0003047 A tumor of a neurilemma, the most common type of neurogenic tumor, usually isolated and encapsulated. Most are benign but occasionally they become malignant. BrendaTissueOBO Schwannoma cell BTO:0003047 neurilemoma cell BTO:0003053 NCI-N87 is a gastric carcinoma cell line derived in 1976 by A. Gazdar and associates at the National Cancer Institute from a liver metastasis of a well differentiated carcinoma of the stomach taken prior to cytotoxic therapy. The tumor was passaged as a xenograft in athymic nude mice for three passages before the cell line was established. BrendaTissueOBO BTO:0003053 NCI-N87 cell BTO:0003064 Mueller cells are astrocyte-like radial glial cells that extend vertically throughout the retina, although their nuclei are usually in the middle of the inner nuclear layer. BrendaTissueOBO Muller cell BTO:0003064 Mueller cell BTO:0003068 Human prostate normal cell line, immortalised with SV40. The primary culture was obtained from the prostate of a 35 year old male at post mortem. BrendaTissueOBO PNT1A cell BTO:0003068 PNT-1A cell BTO:0003070 The hybridoma line S2 has been obtained by fusion of the myeloma P3x63 Ag6.653 and spleen cells from (C57 BL/6 x BALB/c) F1 female mice after a single injection of lymphoblastoid cells. BrendaTissueOBO BTO:0003070 S2 cell BTO:0003082 BrendaTissueOBO uterus epithelium BTO:0003082 uterine epithelium BTO:0003083 BrendaTissueOBO BTO:0003083 uterine wall BTO:0003093 A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. XPMUser 2011-02-23T06:37:01Z BrendaTissueOBO cardiac fibroblast BTO:0003093 cardiofibroblast BTO:0003096 The internal organs in the male that are concerned with reproduction, including the testis, epididymis, ductus deferens, seminal vesicle, ejaculatory duct, prostate, and bulbourethral gland. BrendaTissueOBO organa genitalia masculina interna BTO:0003096 internal male genital organ BTO:0003097 The external genitalia in the male, comprising the penis, scrotum, and urethra. BrendaTissueOBO organa genitalia masculina externa BTO:0003097 external male genital organ BTO:0003098 The pouch that contains the testes and their accessory organs. It is composed of skin, the tunica dartos, the spermatic, cremasteric, and infundibuliform fasciae, and the tunica vaginalis testis. BrendaTissueOBO BTO:0003098 scrotum BTO:0003099 The various organs in the female that are concerned with reproduction, including the ovaries, uterine tubes, uterus, and vagina. BrendaTissueOBO organa genitalia feminina interna BTO:0003099 internal female genital organ BTO:0003100 The external genitalia of the female, comprising the pudendum femininum, clitoris, and urethra. BrendaTissueOBO organa genitalia feminina externa BTO:0003100 external female genital organ BTO:0003101 That portion of the female genitalia comprising the mons pubis, labia majora, labia minora, vestibule of the vagina, bulb of the vestibule, greater and lesser vestibular glands, and vaginal orifice. Commonly used to denote the entire external female genitalia. BrendaTissueOBO puboperineal region pudendum pudendum femininum pudendum muliebre vulva BTO:0003101 female pudendum BTO:0003108 Human lung bronchus carcinoma cell line, derived from a bronchogenic carcinoma of a 45-year-old male. Marion 2014-09-05T10:41:55Z BrendaTissueOBO BTO:0003108 ChaGo-K-1 cell BTO:0003110 HPV18 positive human uterine cervix carcinoma cell line; established from stage IIB squamous cell cervical carcinoma explants from Mexican female at the National University of Mexico. BrendaTissueOBO BTO:0003110 CALO cell BTO:0003119 The preputial glands of female animals are sometimes called clitoral glands. BrendaTissueOBO preputial gland of female BTO:0003119 clitoral gland BTO:0003120 A buildup of cholesterol and fatty material within a blood vessel due to the effects of atherosclerosis. A fatty deposit in the intima (inner lining) of an artery, resulting from atherosclerosis. BrendaTissueOBO arterial plaque atheroma cell BTO:0003120 atherosclerotic plaque BTO:0003123 BrendaTissueOBO MVEC cell BTO:0003123 microvascular endothelial cell BTO:0003124 BrendaTissueOBO BTO:0003124 microvascular endothelial cell line BTO:0003135 A thick, transparent, noncellular layer or envelope of uniform thickness surrounding an oocyte. Under the light microscope it appears as a radially striated layer; under the electron microscope this can be seen to be microvillous. BrendaTissueOBO oolemma pellucid zone striated membrane zona radiata zona striata BTO:0003135 zona pellucida BTO:0003139 Head and neck squamous cell carcinoma (HNSCC) cell line. BrendaTissueOBO SCC-12 cell SCC12 cell UMSCC-12 cell BTO:0003139 UM-SCC-12 cell BTO:0003147 Distinct from adult leaves, being characterized by particular anatomical traits namely, wax and trichome distribution, presence or absence of epidermal cell types, cell wall shape and biochemistry. The first juvenile leaves are e.g. the embryonic leaves found in the grass kernel (caryopsis). BrendaTissueOBO BTO:0003147 juvenile leaf BTO:0003150 BrendaTissueOBO BTO:0003150 pulmonary artery endothelial cell line BTO:0003151 Human pulmonary artery endothelial cell line. BrendaTissueOBO human pulmonary artery endothelial cell BTO:0003151 HPAEC cell BTO:0003152 Cancer that forms in follicular cells in the thyroid and grows in small finger-like shapes. It grows slowly, is more common in women than in men, and often occurs before age 45. It is the most common type of thyroid cancer. BrendaTissueOBO papillary thyroid carcinoma cell BTO:0003152 papillary thyroid cancer cell BTO:0003165 BrendaTissueOBO BTO:0003165 cervical adenocarcinoma cell BTO:0003167 Human fibroblast osteosarcoma cell line lacking the thymidine kinase (TK) gene. BrendaTissueOBO 143BTK cell BTO:0003167 143B cell BTO:0003172 Human colon carcinoma cell line. BrendaTissueOBO KM12 cell BTO:0003172 KM-12 cell BTO:0003173 An endostyle is a longitudinal ciliated groove on the ventral wall of the pharynx which produces mucus to gather food particles. It is found in urochordates and cephalochordates, and in the larvae of lampreys. It aids in transporting food to the esophagus. The endostyle in larval lampreys (ammocetes) metamorphoses into the thyroid gland in adults, and is regarded as being homologous to the thyroid gland in vertebrates. BrendaTissueOBO hypopharyngeal groove BTO:0003173 endostyle BTO:0003178 A muscle having two heads: as a: the large flexor muscle of the front of the upper arm b: the large flexor muscle of the back of the upper leg. BrendaTissueOBO BTO:0003178 biceps BTO:0003179 Any of three muscles at the back of the thigh that function to flex and rotate the leg and extend the thigh. BrendaTissueOBO BTO:0003179 hamstring muscle BTO:0003190 Human hepatocellular carcinoma cell line. BrendaTissueOBO SNU354 cell BTO:0003190 SNU-354 cell BTO:0003191 Human hepatocellular carcinoma cell line. BrendaTissueOBO SNU387 cell BTO:0003191 SNU-387 cell BTO:0003192 BrendaTissueOBO kidney cancer cell line BTO:0003192 renal cancer cell line BTO:0003204 Human renal cancer cell line, established from a 49-years-old male. BrendaTissueOBO BTO:0003204 Caki-1 cell BTO:0003209 Cells to a more primitive or undifferentiated form of thyroid cancer. BrendaTissueOBO BTO:0003209 anaplastic thyroid cancer cell line BTO:0003210 BrendaTissueOBO BTO:0003210 papillary thyroid cancer cell line BTO:0003212 BrendaTissueOBO T-cell lymphoma cell line BTO:0003212 T-lymphoma cell line BTO:0003215 Human prostate cancer cell line. BrendaTissueOBO BTO:0003215 VCaP cell BTO:0003216 Melan-a cells are an immortal pigmented mouse cell line, cultured from epidermal melanoblasts from embryos of inbred C57BL mice. BrendaTissueOBO BTO:0003216 melan-a cell BTO:0003218 Human glioma cell line. BrendaTissueOBO U-343 cell U-343-MG-A cell U343 MG-A cell U343 cell U343-MG-A cell BTO:0003218 U-343 MG-A cell BTO:0003219 Human gastric cancer cell line. BrendaTissueOBO TMK1 cell BTO:0003219 TMK-1 cell BTO:0003221 BrendaTissueOBO BTO:0003221 corneal cell line BTO:0003227 Human hepatocellular carcinoma cell line. BrendaTissueOBO SMMC7721 cell BTO:0003227 SMMC-7721 cell BTO:0003230 Human non-Hodgkin B cell lymphoma cell line. BrendaTissueOBO BTO:0003230 RL cell BTO:0003231 Human glioma cell line. BrendaTissueOBO SHG44 cell BTO:0003231 SHG-44 cell BTO:0003233 Human squamous cell carcinoma cell line of the hypopharynx. BrendaTissueOBO BTO:0003233 FaDu cell BTO:0003234 Rat hepatoma cell line. BrendaTissueOBO FTO2B cell BTO:0003234 FTO-2B cell BTO:0003246 BrendaTissueOBO BTO:0003246 aortic endothelial cell line BTO:0003250 BrendaTissueOBO colon epithelial cell line colonic epithelial cell line BTO:0003250 colonic epithelium cell line BTO:0003252 BrendaTissueOBO BTO:0003252 uterine leiomyoma cell line BTO:0003253 Eker rat uterine leiomyoma-derived cell line. BrendaTissueOBO ELT3 cell BTO:0003253 ELT-3 cell BTO:0003267 Human pancreatic cancer cell line. BrendaTissueOBO HS 766T cell HS766T cell Hs766T cell BTO:0003267 HS-766T cell BTO:0003280 A permanently attached or established cell: not free to move about. BrendaTissueOBO BTO:0003280 sessile cell BTO:0003281 A plankton-like cell. That means the passively floating or weakly swimming usually minute animal and plant life of a body of water. BrendaTissueOBO BTO:0003281 planktonic cell BTO:0003283 The EBV negative SCM1 cell line was originally derived from the gastric specimen of a patient with poorly differentiated tubular adenocarcinoma of the stomach. BrendaTissueOBO SCM1 cell BTO:0003283 SC-M1 cell BTO:0003298 A special adult stem cell, which is a multipotent stem cell, that can be found in bone marrow and can produce all cell types of bone, cartilage, fat, blood, and connective tissues. BrendaTissueOBO MSC cell mesenchymale Stammzelle multipotent mesenchymal stromal cell multipotent stromal cell BTO:0003298 mesenchymal stem cell BTO:0003305 The outer branch of the legs in certain Crustacea. Marion 2010-01-29T11:02:36Z BrendaTissueOBO BTO:0003305 epipodite BTO:0003306 Rat prostate cancer cell line. BrendaTissueOBO MatLyLu cell BTO:0003306 Mat-Ly-Lu cell BTO:0003307 Rat myoblast cell line. BrendaTissueOBO BTO:0003307 L6E9 cell BTO:0003316 Human colorectal cancer cell line. BrendaTissueOBO JB6 clone 41 cell JB6Cl41 cell BTO:0003316 JB6 Cl41 cell BTO:0003317 Rat insulinoma cell line, derived from parental strain INS-1. BrendaTissueOBO INS1E beta cell BTO:0003317 INS-1E cell BTO:0003318 Subline of INS-1 rat insulinoma cell line with optimized glucose-sensitive insulin secretion. BrendaTissueOBO 832/13 INS-1 cell 832/13 cell INS 823/13 cell INS-1 (823/13) cell INS-1 (clone 823-13) cell INS1 832/13 cell INS823/13 cell BTO:0003318 INS-1 823/13 cell BTO:0003320 Human erythroleukemia cell line; established from a 30 years old caucasian male. BrendaTissueOBO HEL (TIB-180) cell HEL 92.1.7 cell HEL TIB 180 cell HEL.92.1.7 cell HEL92.1.7 cell BTO:0003320 HEL-92.1.7 cell BTO:0003321 Human corneal epithelial cell line. BrendaTissueOBO BTO:0003321 HCE cell BTO:0003336 BrendaTissueOBO pulmonary artery smooth muscle BTO:0003336 pulmonary artery smooth muscle cell BTO:0003340 Human lung adenocarcinoma cell line. BrendaTissueOBO BTO:0003340 CL-3 cell BTO:0003349 BrendaTissueOBO BTO:0003349 microglial cell line BTO:0003357 Adult retinal pigment epithelial cell line. BrendaTissueOBO Adult retinal pigment epithelium cell BTO:0003357 ARPE cell BTO:0003358 In anatomy, the area where the upper thigh meets the trunk. More precisely, the fold or depression marking the juncture of the lower abdomen and the inner part of the thigh. BrendaTissueOBO iliac region inguen inguinal region BTO:0003358 groin BTO:0003359 A new or thickened layer of arterial intima formed especially on a prosthesis or in atherosclerosis by migration and proliferation of cells from the media. BrendaTissueOBO BTO:0003359 neointima BTO:0003360 The structure outside the embryonic body; e.g., those membranes involved with the embryos protection and nutrition which are discarded at birth without being incorporated in its body. BrendaTissueOBO extra-embryonic structure extra-embryonic tissue extraembryonic structure BTO:0003360 extraembryonic tissue BTO:0003361 The anterior visceral endoderm (AVE) is an extra-embryonic tissue required for specifying anterior pattern in the mouse embryo. BrendaTissueOBO AVE BTO:0003361 anterior visceral endoderm BTO:0003365 After germination, the grain of barley is called green malt. BrendaTissueOBO green malt BTO:0003365 germinated grain BTO:0003372 A structure, as in liverworts and mosses, on which gametangia are borne. BrendaTissueOBO BTO:0003372 gametophore BTO:0003383 Three membranous semicircular tubes contained in the bony labyrinth of the inner ear. They are concerned with equilibrium and the interpretation of the bodys position in space. The three canals are set anterior, posterior, and lateral, at right angles to each other and are situated superior and posterior to the vestibule. BrendaTissueOBO ductus semicirculares BTO:0003383 semicircular canal BTO:0003393 In neuroscience, granule cells refer to tiny neurons (a type of cell) that are around 10 micrometres in diameter. Granule cells are found within the granular layer of the cerebellum, layer 4 of cerebral cortex, the dentate gyrus of the hippocampus, and in the olfactory bulb. BrendaTissueOBO BTO:0003393 granule cell BTO:0003396 The massive gray matter filling the basilar pons. The nuclei are of fairly homogeneous architecture and project to the cortex of the contralateral cerebellar hemisphere by way of the middle cerebellar peduncle. The pontine nuclei form a major way-station in the impulse conduction from the cerebral cortex of one hemisphere to the posterior lobe of the opposite cerebellum. BrendaTissueOBO nuclei pontis pontine gray matter BTO:0003396 pontine nucleus BTO:0003418 Biceps of the femur. BrendaTissueOBO biceps femoris muscle BTO:0003418 biceps femoris BTO:0003422 Immortalized mesencephalic-derived AF5 cell line. The characterized AF5 rat neural-derived cell line displays GABAergic properties during culture in vitro. BrendaTissueOBO BTO:0003422 AF5 cell BTO:0003423 BrendaTissueOBO BTO:0003423 lacrimal gland acinar cell BTO:0003428 Mouse insulinoma cell line. BrendaTissueOBO beta TC6 cell BTO:0003428 beta-TC6 cell BTO:0003433 The mucous secreting gland associated with the epithelium lining the uterus. These glands develop and secrete each menstrual cycle and are thought to provide initial blastocyst nutrition prior to implantation. BrendaTissueOBO BTO:0003433 endometrial gland BTO:0003434 A term, in the series used to describe developmental stages of the parasitic flagellates, denoting the barleycorn form of the flagellate in the genus Crithidia characterised by a collarlike extension surrounding the anterior and through which the single flagellum emerges. BrendaTissueOBO choanoflagellate collared flagellate BTO:0003434 choanomastigote BTO:0003438 Human melanoma cell line, derived from lymph node metastasis. BrendaTissueOBO WM9 cell BTO:0003438 WM-9 cell BTO:0003445 Cholesterol plaques on the inner wall of the carotid artery can lead to stroke. BrendaTissueOBO atherosclerotic carotid plaque carotid plaque BTO:0003445 carotid atherosclerotic plaque BTO:0003449 Murine non-transformed normal liver cell line. BrendaTissueOBO AML 12 cell AML12 cell BTO:0003449 AML-12 cell BTO:0003452 BrendaTissueOBO lipocyte cell line BTO:0003452 adipocyte cell line BTO:0003453 The calcified tissue below the enamel, enclosing the cavity of the tooth containing the pulp chamber and root canals. BrendaTissueOBO BTO:0003453 dentin BTO:0003461 Human urinary bladder carcinoma cell line; established from a transurethral resection of invasive, moderately pleomorphic (grade 3) bladder transitional cell carcinoma of a 58-year-old Caucasian woman who had not received chemo- or radiotherapy. BrendaTissueOBO HT1376 cell BTO:0003461 HT-1376 cell BTO:0003467 Human melanoma cell line. BrendaTissueOBO HS-294 cell Hs 294T cell Hs294 cell Hs294T cell BTO:0003467 HS-294T cell BTO:0003472 Either of the 10th pair of cranial nerves that arise from the medulla and supply chiefly the viscera especially with autonomic sensory and motor fibers. BrendaTissueOBO cranial nerve X nervus vagus pneuomgastric nerve tenth cranial nerve vagus BTO:0003472 vagus nerve BTO:0003478 Human gastric cancer cell line. BrendaTissueOBO SNU638 cell BTO:0003478 SNU-638 cell BTO:0003483 BrendaTissueOBO BTO:0003483 sebaceous gland cell line BTO:0003487 Visceral endoderm, a population of extraembyonic endoderm, is an extraembryonic tissue that functions in a regulatory capacity but does not contribute directly to the formation of any adult organs. BrendaTissueOBO BTO:0003487 visceral endoderm BTO:0003499 Human ovarian carcinoma cell line from clear cell adenocarcinoma. BrendaTissueOBO BTO:0003499 OVTOKO cell BTO:0003505 2-5% of all chronic lymphoproliferative disorders in the West, and 5-6% in the Chinese population. Large granular lymphocytes (LGLs) with the nucleus of a small lymphocyte but abundant cytoplasm and fine or coarse azurophilic granules; ultrastructural examination may reveal characteristic parallel tubular arrays; the LGLs are often >2x109/L. BrendaTissueOBO T-LGL cell T-cell large granular lymphocytic leukemia cell Tgamma lymphoproliferative disorder cell large granular lymphocytosis cell BTO:0003505 T-cell chronic lymphocytic leukemia cell BTO:0003508 Human malignant melanoma cell line; established from an involved lymph node of an 18-year-old Caucasian woman with malignant melanoma in 1971. BrendaTissueOBO RPMI7951 cell BTO:0003508 RPMI-7951 cell BTO:0003536 Human non-small cell lung cancer adenocarcinoma cell line. This line was derived from a lung cancer obtained from a 60 years old caucasian male patient prior to therapy. BrendaTissueOBO H-522 cell H522 cell BTO:0003536 NCI-H522 cell BTO:0003542 The LAN-1 clone, a cell line derived from a human neuroblastoma, possesses muscarinic receptors. BrendaTissueOBO LAN1 cell BTO:0003542 LAN-1 cell BTO:0003556 Murine septal cholinergic neuronal cell line. BrendaTissueOBO SN56 cell BTO:0003556 SN-56 cell BTO:0003558 Human mantle cell lymphoma (B cell non-Hodgkin's lymphoma) cell line. BrendaTissueOBO BTO:0003558 REC-1 cell BTO:0003566 Mouse pituitary tumor cell line. BrendaTissueOBO BTO:0003566 alphaT3-1 cell BTO:0003568 BrendaTissueOBO BTO:0003568 mammary gland cell line BTO:0003585 Human large cell immunoblastic lymphoma cell line, derived from a pleural effusion of a 11 years old caucasian boy. BrendaTissueOBO SR NHL cell BTO:0003585 SR cell BTO:0003595 1: A joint in the middle part of the human leg that is the articulation between the femur, tibia, and patella; also: the part of the leg that includes this joint. 2a: The joint in the hind leg of a four-footed vertebrate that corresponds to the human knee. 2b: The carpal joint of the foreleg of a four-footed vertebrate. 2c: The tarsal joint of a bird. 2d: The joint between the femur and tibia of an insect. BrendaTissueOBO BTO:0003595 knee BTO:0003600 A unique, relatively rare intestinal epithelial cell type specialized for transepithelial transport of macromolecules, particles, and microorganisms. M cells in many species, including humans can be identified by morphological features such as their flattened apical surfaces and intraepithelial pockets containing lymphoid cells. BrendaTissueOBO M-cell BTO:0003600 M cell BTO:0003604 The functional tissue of the kidney, consisting of the nephrons. Marion 2010-01-29T11:24:56Z BrendaTissueOBO kidney parenchyma BTO:0003604 renal parenchyma BTO:0003605 Human astrocytoma cell line. BrendaTissueOBO 1321 N1 cell 1321N1 cell BTO:0003605 1321-N1 cell BTO:0003617 A term most commonly used to describe the fluid drained from the peritoneal cavity some time after the injection of an irritant solution. For example: a standard method for obtaining neutrophil leucocytes is to inject intraperitoneally saline with glycogen (to activate complement) and drain off the leucocyte rich peritoneal exudate some hours later. BrendaTissueOBO BTO:0003617 peritoneal exudate BTO:0003620 Bone marrow culture-derived mast cells. BrendaTissueOBO bone marrow mononuclear cell bone marrow-derived mast cell BTO:0003620 BMMC cell BTO:0003623 BrendaTissueOBO BTO:0003623 uterine fluid BTO:0003627 A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart). BrendaTissueOBO annulus anulus anulus fibrosus fibrous ring BTO:0003627 annulus fibrosus BTO:0003629 The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised. BrendaTissueOBO annulus fibrosus of intervertebral disc fibrous ring of intervertebral disc BTO:0003629 annulus fibrosus disci intervertebralis BTO:0003632 The fluid of the uterine cervix and the vagina. BrendaTissueOBO BTO:0003632 cervicovaginal fluid BTO:0003640 BrendaTissueOBO BTO:0003640 esophageal cell line BTO:0003642 Murine hepatocarcinoma cell line. BrendaTissueOBO BTO:0003642 Hca-F cell BTO:0003646 Carcinoma arising in a benign mixed tumour of a salivary gland, characterised by rapid enlargement and pain. BrendaTissueOBO carcinoma ex pleomorphic adenoma BTO:0003646 pleomorphic adenoma cell BTO:0003649 A portion of the forebrain of vertebrates. It is found behind the olfactory bulb and in front of the piriform cortex (laterally) and olfactory tubercle (medially) in a region often referred to as the olfactory peduncle or retrobulbar area. The peduncle contains the anterior olfactory nucleus (AON) as well as two other much smaller regions, the tenia tecta (or dorsal hippocampal rudiment) and the dorsal peduncular cortex. BrendaTissueOBO AON anterior olfactory cortex BTO:0003649 anterior olfactory nucleus BTO:0003650 BrendaTissueOBO BTO:0003650 optic ganglion BTO:0003651 A fusiform cell, such as those in the deeper layers of the cerebral cortex. BrendaTissueOBO BTO:0003651 spindle cell BTO:0003659 Cell specialised for secretion, usually epithelial. Those that secrete proteins characteristically have well developed rough endoplasmic reticulum, whereas conspicuous smooth endoplasmic reticulum is typical of cells that secrete lipid or lipid derived products (e.g. Steroids). BrendaTissueOBO BTO:0003659 secretory cell BTO:0003660 The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform. BrendaTissueOBO BTO:0003660 laryngeal cartilage BTO:0003661 BrendaTissueOBO ovarian epithelium BTO:0003661 ovary epithelium BTO:0003666 Any of approximately 25,000 hair cells in the organ of Corti, specialized as transducers of sound waves into nerve impulses and sensitive to low sound levels, easily damaged by loud noise (over 85 decibels), and probably involved in encoding information about the loudness of sounds. So called because they are nearer to the outside of the cochlea than are the inner hair cells. BrendaTissueOBO BTO:0003666 outer hair cell BTO:0003667 Any of approximately 3,500 hair cells, situated in the organ of Corti, specialized as transducers of sound waves into nerve impulses and believed to encode information about the frequency of sound. So called because they are further from the outside of the cochlea than are the outer hair cells. BrendaTissueOBO BTO:0003667 inner hair cell BTO:0003671 The area in the center of a lymph node containing aggregations of actively proliferating lymphocytes. BrendaTissueOBO BTO:0003671 germinal center BTO:0003673 The modified part of a somite of a vertebrate embryo that develops into a segmental excretory tubule of the primitive kidney. BrendaTissueOBO intermediate cell mass BTO:0003673 nephrotome BTO:0003674 The joint that connects the lower jaw to the skull. BrendaTissueOBO TMJ BTO:0003674 temporomandibular joint BTO:0003676 Lymphocytic leukemia characterized by an abnormal increase in the number of lymphoblasts. BrendaTissueOBO BTO:0003676 lymphoblastic leukemia cell BTO:0003680 Human Caucasian peripheral blood hairy cell leukaemia B-lymphoblast cell line. BrendaTissueOBO Mo B cell BTO:0003680 Mo-B cell BTO:0003681 A form of chronic leukemia marked by splenomegaly and the large, mononuclear, villus-covered cells called hairy cells in the bone marrow, spleen, liver, and peripheral blood. BrendaTissueOBO BTO:0003681 hairy cell leukemia cell line BTO:0003684 A component of the epithalamus, being the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone. BrendaTissueOBO pineal peduncle BTO:0003684 habenula BTO:0003693 BrendaTissueOBO NK-LGL cell BTO:0003693 natural killer large granular lymphocytic leukemia cell BTO:0003694 BrendaTissueOBO BTO:0003694 CNS cell line BTO:0003695 A CNS catecholaminergic cell line. BrendaTissueOBO BTO:0003695 CAD cell BTO:0003696 Human osteosarcoma-derived U2OS cell line. BrendaTissueOBO BTO:0003696 ATRkd cell BTO:0003709 Epithelial cells derived from the peripheral zone of a histologically normal adult human prostate were transfected with a single copy of the human papilloma virus 18 to establish the cell line. BrendaTissueOBO RWPE1 cell BTO:0003709 RWPE-1 cell BTO:0003716 Scrapie-infected mouse neuroblastoma N2a cell line. BrendaTissueOBO BTO:0003716 ScN2a cell BTO:0003718 The blood vessels or arrangement of blood vessels in an organ or part. BrendaTissueOBO BTO:0003718 vasculature BTO:0003724 Human urinary bladder transitional cell carcinoma established from the transitional cell carcinoma histological grade G2 excised from a female patient with untreated primary urinary bladder carcinoma in 1973. BrendaTissueOBO RT 112 cell RT112 cell BTO:0003724 RT-112 cell BTO:0003726 Small cell lung cancer cell line; established in 1977; derived from a non-encapsulated primary lung tumor from the apical portion of the upper lobe of the left lung. This cell line is an unusual undifferentiated large cell variant of small cell lung carcinoma. BrendaTissueOBO BTO:0003726 SHP-77 cell BTO:0003728 Human melanoma cell line. BrendaTissueOBO TXM13 cell BTO:0003728 TXM-13 cell BTO:0003736 An epithelial cell lining the thyroid follicle. BrendaTissueOBO thyrocyte thyroid follicular cell BTO:0003736 thyroid epithelial cell BTO:0003744 Cell line of a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh. Most frequent in middle-aged and older adults (age 40 and above), liposarcomas are the most common of all soft-tissue sarcomas. BrendaTissueOBO BTO:0003744 liposarcoma cell line BTO:0003745 A malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh. Most frequent in middle-aged and older adults (age 40 and above), liposarcomas are the most common of all soft-tissue sarcomas. BrendaTissueOBO BTO:0003745 liposarcoma cell BTO:0003751 Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue. BrendaTissueOBO BTO:0003751 submucosal gland BTO:0003761 Human glioblastoma cell line; established from the surgical resection of a left parieto-occipital glioblastoma from a 47-year-old man in 1980. BrendaTissueOBO SNB19 cell BTO:0003761 SNB-19 cell BTO:0003769 Human kidney carcinoma cell line; established from the kidney carcinoma of a 52-year-old man in 1973. BrendaTissueOBO A498 cell BTO:0003769 A-498 cell BTO:0003773 BrendaTissueOBO BTO:0003773 oropharyngeal squamous cell carcinoma cell BTO:0003776 BrendaTissueOBO BTO:0003776 urinary bladder squamous cell carcinoma cell line BTO:0003777 Human urinary bladder squamous cell carcinoma cell line; established from a 58 years old black men. BrendaTissueOBO BTO:0003777 SCaBER cell BTO:0003797 Trichome that consists of one cell. BrendaTissueOBO BTO:0003797 unicellular trichome BTO:0003798 Trichome that consists of several cells. BrendaTissueOBO BTO:0003798 multicellular trichome BTO:0003800 Normal rat thyroid cell line. BrendaTissueOBO PCCL3 cell PCCl3 cell BTO:0003800 PCCL-3 cell BTO:0003802 The larger and usually female gamete of a heterogamous organism. BrendaTissueOBO BTO:0003802 macrogamete BTO:0003803 BrendaTissueOBO BTO:0003803 serous adenocarcinoma cell line BTO:0003834 A fertilized egg, embryo, or fetus. BrendaTissueOBO BTO:0003834 conceptus BTO:0003835 Four accumulations of gray substance embedded in the white substance of the cerebellum, comprising the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii. BrendaTissueOBO BTO:0003835 cerebellar nucleus BTO:0003840 System pertaining to blood vessels in the brain. BrendaTissueOBO BTO:0003840 cerebrovascular system BTO:0003848 A type of cancer that most often develops in the salivary glands of the head and neck. It may arise in other sites such as the skin, lacrimal gland, trachea, breast, cervix and prostate. BrendaTissueOBO adenoid cystic cancer cell BTO:0003848 adenoid cystic carcinoma cell BTO:0003849 A type of cancer that contains two types of cells: squamous cells (thin, flat cells that line certain organs) and gland-like cells. BrendaTissueOBO adenosquamous cell carcinoma cell BTO:0003849 adenosquamous carcinoma cell BTO:0003858 BrendaTissueOBO BTO:0003858 chondrocyte cell line BTO:0003860 Human chondrocyte cell line. BrendaTissueOBO BTO:0003860 T/C-28a2 cell BTO:0003863 Human brain grade IV astrocytoma cell line; established from a 68-years-old caucasian female. BrendaTissueOBO BTO:0003863 CCF-STTG1 cell BTO:0003865 A group of APUD cells found scattered along the walls of the gastrointestinal tract; their secretions affect motility, secretion of pancreatic enzymes and bile, and growth of the gastrointestinal tract epithelium, and are regulators of other endocrine substances in the intestines. BrendaTissueOBO basal granular cell BTO:0003865 enteroendocrine cell BTO:0003866 A group of apparently unrelated cells that secrete most of the body's hormones, with the exception of steroids. BrendaTissueOBO BTO:0003866 APUD cell BTO:0003870 The respiratory system of insects that consists of internal airfilled tubes. BrendaTissueOBO tracheal system BTO:0003870 insect tracheal system BTO:0003871 More than 95% of uterine cancers arise in the endometrium. Endometrial cancer develops when the cells that make up the endometrium become abnormal and grow uncontrollably. BrendaTissueOBO endometrial cancer cell endometrial carcinoma cell uterine endometrial carcinoma cell BTO:0003871 uterine endometrial cancer cell BTO:0003874 BrendaTissueOBO follicular thyroid carcinoma cell line BTO:0003874 follicular thyroid cancer cell line BTO:0003877 Human osteosarcoma cell line. BrendaTissueOBO G292 cell BTO:0003877 G-292 cell BTO:0003878 Human gastric cancer cell line. BrendaTissueOBO BGC823 cell BTO:0003878 BGC-823 cell BTO:0003883 BrendaTissueOBO BTO:0003883 pancreatic ductal adenocarcinoma cell line BTO:0003894 BrendaTissueOBO BTO:0003894 skin carcinoma cell line BTO:0003898 GT1 cells belong to an immortalized line of mouse hypothalamic GnRH secreting neurons that exhibit a pulsatile secretion of GnRH. BrendaTissueOBO BTO:0003898 GT1 cell BTO:0003899 Immortalized GnRH secreting mouse neuronal cell line. BrendaTissueOBO BTO:0003899 GT1-1 cell BTO:0003900 Normal breast epithelial cell line. BrendaTissueOBO MCF10F cell BTO:0003900 MCF-10F cell BTO:0003904 Homo sapiens bone osteosarcoma cell line; established from a 13-years-old caucasian female. BrendaTissueOBO BTO:0003904 HOS cell BTO:0003906 The epithelium of the urinary tract. The lining of the ureters, bladder, and urethra. BrendaTissueOBO urothelium BTO:0003906 uroepithelium BTO:0003907 BrendaTissueOBO urothelial cell line BTO:0003907 uroepithelial cell line BTO:0003912 Renal inner medullary collecting duct (IMCD) cell line. BrendaTissueOBO BTO:0003912 IMCD cell BTO:0003914 Pleomorphic cells having an oval nucleus and long, branching cytoplasmic processes that interlace with processes of adjacent cells, interspersed between the circular and longitudinal muscle layers of the gastrointestinal tract and in the smooth muscle of the esophagus; they are thought to act as pacemakers. BrendaTissueOBO ICC cell BTO:0003914 interstitial cell of Cajal BTO:0003917 Human cervix carcinoma cell line resistant to vinblastine; a multidrug-resistant (mdr) subclone derived from KB-3-1. BrendaTissueOBO BTO:0003917 KB-V1 cell BTO:0003927 A tailless encysted late larva of a trematode parasite that is usually the form which is infective for the definitive host. BrendaTissueOBO BTO:0003927 metacercaria BTO:0003929 Multiple myeloma cell line. BrendaTissueOBO MM-1R cell MM.1R cell MM1.R cell BTO:0003929 MM1-R cell BTO:0003936 BrendaTissueOBO LSCC cell BTO:0003936 laryngeal squamous cell carcinoma cell BTO:0003941 This cell line was originally described as a spindle shaped variant of the parental MDA-MB-435 strain isolated from the pleural effusion of a 31 year old female with metastatic, ductal adenocarcinoma of the breast. However, recent studies have reported that this line is cross-contaminated with is the M14 melanoma line. BrendaTissueOBO MDA-MB-435 S cell MDA-MB-435-S cell BTO:0003941 MDA-MB-435S cell BTO:0003945 The MN9D murine dopaminergic cell line was generated by fusion of rostral mesencephalic neurons from embryonic C57BL/6J (embryonic day 14) mice with N18TG2 neuroblastoma cells. BrendaTissueOBO MN9D cell BTO:0003945 MN-9D cell BTO:0003946 Mouse macula densa-derived cell line. BrendaTissueOBO MMDD-1 cell BTO:0003946 MMDD1 cell BTO:0003953 An embryonic blastomere or cell layer not yet differentiated into mesoderm and endoderm but destined to give rise to both. BrendaTissueOBO mesendoderm BTO:0003953 endomesoderm BTO:0003954 The system of nerve cells that uses dopamine as its neurotransmitter. BrendaTissueOBO BTO:0003954 dopaminergic system BTO:0003957 Murine microglial cell line. BrendaTissueOBO N9 cell BTO:0003957 N-9 cell BTO:0003960 BrendaTissueOBO BTO:0003960 nasopharyngeal carcinoma cell line BTO:0003963 Gray matter located in the dorsomedial part of the medulla oblongata associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of autonomic nervous system regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of homeostasis. The solitary nucleus is also notable for the large number of neurotransmitters which are found therein. BrendaTissueOBO Geschmackskern nucleus tractus solitarii solitary nucleus BTO:0003963 nucleus solitarius BTO:0003975 A part of the brain situated in the medial aspect of the cortex. It is extended from the corpus callosum below to the cingulate sulcus above, at least anteriorly. BrendaTissueOBO BTO:0003975 cingulate cortex BTO:0003994 A hoofed foot especially of a horse. BrendaTissueOBO BTO:0003994 hoof BTO:0004007 Porcine aortic endothelial cell line. BrendaTissueOBO PAEC cell BTO:0004007 porcine aortic endothelial cell BTO:0004012 Rat osteosarcoma cell line. BrendaTissueOBO BTO:0004012 ROS cell BTO:0004032 A dopaminergic neuron is a neuron that releases dopamine from its synapses. Dopaminergic neurons are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus. They are believed to be the primary neuron used in the reward system of the ventral tegmental area and the substantia nigra pars compacta. BrendaTissueOBO BTO:0004032 dopaminergic neuron BTO:0004038 An abnormal growth of tissue in animals or plants. Neoplasms can be benign or malignant. XPMUser 2013-03-15T12:16:35Z BrendaTissueOBO colonic tumor cell BTO:0004038 colonic neoplasm cell BTO:0004041 Adipose tissue located inside the peritoneal cavity, packed in between internal organs and torso. An excess of visceral fat is known as central obesity, or belly fat, the pot belly or beer belly effect, in which the abdomen protrudes excessively. BrendaTissueOBO abdominal fat intra-abdominal fat organ fat visceral adipose tissue visceral fat BTO:0004041 abdominal adipose tissue BTO:0004042 Adipose tissue which is found underneath the skin. BrendaTissueOBO subcutaneous fat BTO:0004042 subcutaneous adipose tissue BTO:0004044 An unipolar nerve cell found in the retina, in the olfactory bulb, and in close connection with the Purkinje cells of the cerebellum. BrendaTissueOBO BTO:0004044 amacrine cell BTO:0004046 The mucous membrane apical to the attached gingiva. BrendaTissueOBO BTO:0004046 alveolar mucosa BTO:0004050 Human liver cancer cell line. BrendaTissueOBO BEL7402 cell BTO:0004050 BEL-7402 cell BTO:0004051 A type of neuron which has two extensions. Bipolar cells are specialized sensory neurons for the transmission of special senses. As such, they are part of the sensory pathways for smell, sight, taste, hearing and vestibular functions. BrendaTissueOBO BTO:0004051 bipolar cell BTO:0004052 Bone marrow stem cells are the most primitive cells in the marrow. From them all the various types of blood cells are descended. BrendaTissueOBO BMSC cell Knochenmark-Stammzelle Knochenmarkstammzelle BTO:0004052 bone marrow stem cell BTO:0004053 Blood from the umbilical cord of a newborn baby. This blood contains high concentrations of stem cells. BrendaTissueOBO cord blood BTO:0004053 umbilical cord blood BTO:0004055 A cell line derived from the african green monkey and used for transfection and cloning. The cells are simian fibroblasts (cv 1 cells) transformed by sv40 that is deficient in the origin of replication region. They express large t antigen constitutively and if transfected with a vector containing a normal sv40 origin have all the other early viral genes necessary to generate multiple copies of the vector and thus to give very high levels of expression. BrendaTissueOBO BTO:0004055 COS cell BTO:0004057 Juice produced by squeezing or crushing fruit. BrendaTissueOBO BTO:0004057 fruit juice BTO:0004059 Human normal colon fibroblast cell line established from a black 2.5-months-old human female. BrendaTissueOBO BTO:0004059 CCD-18Co cell BTO:0004078 BrendaTissueOBO BTO:0004078 non-small cell lung adenocarcinoma cell line BTO:0004082 Non-small cell lung adenocarcinoma cell line. BrendaTissueOBO HCC827 cell BTO:0004082 HCC-827 cell BTO:0004086 BrendaTissueOBO mammary tumor cell line BTO:0004086 mammary gland tumor cell line BTO:0004094 Cancer that occurs in the cells on the surface of the ovary. BrendaTissueOBO EOC cell ovarian epithelial cancer cell BTO:0004094 epithelial ovarian cancer cell BTO:0004097 Cell with empty-appearing cytoplasm; seen normally in the sweat glands, the parathyroid glands, the collecting tubules of the kidneys, and the epididymis; they also appear in some types of cancer. BrendaTissueOBO BTO:0004097 epididymal clear cell BTO:0004101 A bundle of thin leaves of pines. BrendaTissueOBO plant fascicle BTO:0004101 fascicle BTO:0004103 The first stage of leaf development; a small lateral protuburance formed by an apical shoot meristem that will expand to form a leaf. XPMUser 2011-02-24T10:17:00Z BrendaTissueOBO primordial leaf BTO:0004103 leaf primordium BTO:0004111 A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant. BrendaTissueOBO GIST cell BTO:0004111 gastrointestinal stromal tumor cell BTO:0004114 BrendaTissueOBO BTO:0004114 adrenocortical carcinoma cell line BTO:0004124 Human urinary bladder carcinoma cell line, established from a 44 years old caucasian male. BrendaTissueOBO HT 1197 cell HT1197 cell BTO:0004124 HT-1197 cell BTO:0004129 BrendaTissueOBO ovarian epithelial cell line BTO:0004129 ovary epithelium cell line BTO:0004137 A Philadelphia chromosome-positive cell line established from peripheral blood of a patient with chronic myelogenous leukemia in blast crisis. BrendaTissueOBO KCL22 cell BTO:0004137 KCL-22 cell BTO:0004139 Growth factor-dependent human mast cell line. BrendaTissueOBO LAD 2 cell LAD2 cell BTO:0004139 LAD-2 cell BTO:0004147 That portion of the spine comprising the lumbar vertebrae. BrendaTissueOBO BTO:0004147 lumbar spine BTO:0004148 That portion of the spine comprising the cervical vertebrae. The neck area of the spine. BrendaTissueOBO BTO:0004148 cervical spine BTO:0004152 Human melanoma cell line. BrendaTissueOBO UACC 62 cell UACC62 cell BTO:0004152 UACC-62 cell BTO:0004170 Clone of MHCC97 with low metastatic potential. BrendaTissueOBO MHCC 97-L cell MHCC97Lcell BTO:0004170 MHCC97-L cell BTO:0004171 Human T cell leukemia cell line; established from the bone marrow of a 2-year-old girl with T-ALL (T cell acute lymphoblastic leukemia, FAB L2) at relapse in 1983. BrendaTissueOBO BTO:0004171 MOLT-13 cell BTO:0004176 Human acute myeloid leukemia cell line; established in 1999 from the peripheral blood of a 77-year-old Japanese woman at relapse of acute myeloid leukemia (AML M0) after failed chemotherapy. BrendaTissueOBO MOLM16 cell BTO:0004176 MOLM-16 cell BTO:0004178 A normal stem or progenitor cell undergoes a mutation, giving rise to an entity that is functionally defined as a leukemic stem cell. The mutated stem cells differentiate into the hematopoietic lineage carrying the defect/s or can remain as immature progenitor cells, the blast cells. BrendaTissueOBO LSC cell BTO:0004178 leukemic stem cell BTO:0004180 Human pluripotent embryonal carcinoma, teratocarcinoma cell line; established in 1985 from a mediastinal mixed germ cell tumor of an adult Japanese male. This pluripotent stem cell line is capable of somatic and extraembryonic differentiation. BrendaTissueOBO BTO:0004180 NCCIT cell BTO:0004185 Neurons in the olfactory epithelium with proteins that bind, and thus detect, odorants. Olfactory receptor neurons are bipolar. Unlike other neurons, they can be generated from precursor cells in adults. BrendaTissueOBO olfactory neuron olfactory sensory neuron BTO:0004185 olfactory receptor neuron BTO:0004190 A group of cells or a body part (as the sinus node of the heart) that serves to establish and maintain a rhythmic activity. BrendaTissueOBO Reizbildungszentrum BTO:0004190 pacemaker cell BTO:0004203 Rat intestinal epithelial cell line. BrendaTissueOBO BTO:0004203 RIE-1 cell BTO:0004210 A type of cancer of the testicles. Seminomas may spread to the lung, bone, liver, or brain. BrendaTissueOBO BTO:0004210 seminoma cell BTO:0004212 A hair-like unicellular external process of the body wall or any derivative of the latter, a hair, a bristle. BrendaTissueOBO bristle BTO:0004212 seta BTO:0004213 Human glioblastoma cell line. BrendaTissueOBO SF295 cell BTO:0004213 SF-295 cell BTO:0004217 Neuroblastoma cell line derived in 1978 from a bone marrow metastasis from a 2 years old caucasian female child with poorly differentiated embryonal neuroblastoma. BrendaTissueOBO BTO:0004217 SK-N-DZ cell BTO:0004223 BrendaTissueOBO SCCC cell squamous cell cervical carcinoma cell BTO:0004223 cervical squamous cell carcinoma cell BTO:0004229 BrendaTissueOBO BTO:0004229 testicular cell line BTO:0004230 Mouse testicular Sertoli cell line. BrendaTissueOBO TM4 cell BTO:0004230 TM-4 cell BTO:0004232 A transformed human kidney 293 cell line stably expressing an SV40 temperature-sensitive T antigen. BrendaTissueOBO tsA201 cell BTO:0004232 tsA-201 cell BTO:0004235 The portion of the uterus to which the intramural section of the uterine tube enters on either the right or left. BrendaTissueOBO cornu uteri BTO:0004235 uterine horn BTO:0004237 BrendaTissueOBO uterine smooth muscle cell line BTO:0004237 myometrial cell line BTO:0004238 The cells of the connective tissue of the ovary and testis (Leydig cells), which furnish the internal secretion of those structures. BrendaTissueOBO BTO:0004238 interstitial cell BTO:0004242 The female system is unusual in that it is separated into two structures: the ovaries and the vitellaria, often known as the vitelline glands or yolk glands. The cells of the vitellaria form yolk and eggshell components. BrendaTissueOBO vitelline gland yolk gland BTO:0004242 vitellarium BTO:0004249 That portion of the cingulate cortex which is located within the frontal lobe (the remainder being in the parietal lobe). It is believed to be involved in the processing of attention. BrendaTissueOBO ACC cell BTO:0004249 anterior cingulate cortex BTO:0004253 The new vegetative growth of Pinus taeda plants in the center surrounded by young male cones. This young growth is called a candle and will expand into stem and needles. BrendaTissueOBO candle BTO:0004253 plant candle BTO:0004254 Cancer stem cells are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are tumorigenic. BrendaTissueOBO CSC cell Krebsstammzelle BTO:0004254 cancer stem cell BTO:0004255 The Ewing's family of tumors includes Ewing's tumor of bone, extraosseus Ewing's sarcoma, primitive neuroectodermal tumors, and Askin's tumor. All of these tumors are derived from the same primordial stem cell, the primitive nerve cell. BrendaTissueOBO EFT cell BTO:0004255 Ewing's family tumor cell BTO:0004256 In limbs of vertebrate animals. A long cylindrical bone that contains marrow. Marion 2010-01-29T03:14:18Z BrendaTissueOBO os longum BTO:0004256 long bone BTO:0004270 Hepatic progenitor cells can be isolated from fetal liver and extrahepatic tissues. BrendaTissueOBO HPC cell adulte Leberstammzelle hepatic oval cell hepatic progenitor cell BTO:0004270 adult liver stem cell BTO:0004271 A cell occurring in the peripheral part of the vitreous body that may be responsible for production of hyaluronic acid and possibly of collagen. BrendaTissueOBO vitreous cell BTO:0004271 hyalocyte BTO:0004281 HTLV-1-infected human T-cell line; established from patients with T-cell leukemia. BrendaTissueOBO C81 cell BTO:0004281 C-81 cell BTO:0004282 TSA is an aggressive and poorly immunogenic cell line established from a moderately differentiated mammary adenocarcinoma that arose spontaneously in a multiparous BALB/c mouse. BrendaTissueOBO BTO:0004282 TSA cell BTO:0004286 A rare type of leukemia in which basophils predominate; both acute and chronic varieties have been observed. BrendaTissueOBO BTO:0004286 basophilic leukemia cell BTO:0004296 BrendaTissueOBO BTO:0004296 umbilical vein endothelial cell BTO:0004324 BrendaTissueOBO BTO:0004324 osteoblast cell line BTO:0004326 Human continuous glioblastoma cell line. BrendaTissueOBO BTO:0004326 ADF cell BTO:0004328 Human medulloblastoma cell line. BrendaTissueOBO BTO:0004328 DAOY cell BTO:0004339 Derived from the mouse hypothalamic cell line GT1, infected with mouse scrapie prions. BrendaTissueOBO BTO:0004339 ScGT1 cell BTO:0004351 A narrow strip of cell groups on the dorsomedial surface of the thalamus. It includes the lateral dorsal nucleus, lateral posterior nucleus, and the PULVINAR. BrendaTissueOBO BTO:0004351 lateral posterior nucleus BTO:0004352 Large mass of nuclei forming the most caudal portion of the thalamus and overhanging the geniculate bodies and the dorsolateral surface of the midbrain. It is divided into four parts: the lateral, medial, inferior, and oral pulvinar nuclei. BrendaTissueOBO BTO:0004352 pulvinar BTO:0004358 A small mass of tissue that is embedded in the musculature of the right atrium of higher vertebrates and that originates the impulses stimulating the heartbeat. BrendaTissueOBO sinoatrial node BTO:0004358 sinus node BTO:0004364 The junction between the stomach and the esophagus; the place where the esophagus connects to the stomach. BrendaTissueOBO BTO:0004364 gastroesophageal junction BTO:0004365 BrendaTissueOBO gastro-esophageal cancer cell gastro-oesophageal cancer cell gastroesophageal carcinoma cell gastroesophageal junction carcinoma cell BTO:0004365 gastroesophageal cancer cell BTO:0004368 Any of four nuclei in the medulla oblongata on each side of the floor of the fourth ventricle of the brain in which fibers of the vestibular nerve terminate. BrendaTissueOBO BTO:0004368 vestibular nucleus BTO:0004371 The one of the four vestibular nuclei on each side of the medulla oblongata that sends ascending fibers to the oculomotor and trochlear nuclei in the cerebrum on the opposite side of the brain and sends descending fibers down both sides of the spinal cord to synapse with motor neurons of the ventral roots. BrendaTissueOBO BTO:0004371 medial vestibular nucleus BTO:0004378 BrendaTissueOBO vascular wall BTO:0004378 blood vessel wall BTO:0004385 Any of four longitudinal veins of the vertebrate embryo running anteriorly and posteriorly along each side of the spinal column with the pair on each side meeting at and discharging blood to the heart through the corresponding duct of Cuvier. BrendaTissueOBO Cuvierian vein cardinal sinus BTO:0004385 cardinal vein BTO:0004395 A blood vessel as a capillary, arteriole, or venule of the microcirculatory system. Marion 2010-01-29T03:21:57Z BrendaTissueOBO BTO:0004395 microvessel BTO:0004398 Marion 2010-02-01T09:41:16Z BrendaTissueOBO BTO:0004398 meningioma cell line BTO:0004410 The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells and dendritic cells. Marion 2010-02-01T11:01:31Z BrendaTissueOBO BTO:0004410 culture condition:CD8+ cell BTO:0004414 Murine embryonic stem cell line. Marion 2010-02-01T11:56:40Z BrendaTissueOBO BTO:0004414 KH2 cell BTO:0004416 Spontaneous T cell lymphoma. Marion 2010-02-01T01:24:28Z BrendaTissueOBO Dalton's lymphoma cell BTO:0004416 Daltons lymphoma cell BTO:0004422 The space enclosed by the pleura, which is a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity. Marion 2010-02-01T02:05:38Z BrendaTissueOBO BTO:0004422 pleural cavity BTO:0004423 The presence of pus in a body cavity, especially the pleural cavity. Marion 2010-02-01T02:06:20Z BrendaTissueOBO empyema BTO:0004423 empyema fluid BTO:0004438 Human squamous cell carcinoma cell line. Marion 2010-02-02T03:08:47Z BrendaTissueOBO hSCC cell human SCC cell BTO:0004438 HSCC cell BTO:0004439 Marion 2010-02-02T03:17:50Z BrendaTissueOBO BTO:0004439 hypopharyngeal carcinoma cell line BTO:0004446 The S9 cell line and the C38 cell line were derived from the IB3-1 cell line. Marion 2010-02-02T03:35:11Z BrendaTissueOBO JHU-53 cell BTO:0004446 S9 cell BTO:0004462 Imatinib resistant subline of K562. Marion 2010-02-02T04:01:32Z BrendaTissueOBO K562R cell BTO:0004462 K-562R cell BTO:0004467 Murine pituitary gonadotrope cell line. Marion 2010-02-04T09:45:37Z BrendaTissueOBO BTO:0004467 LbetaT2 cell BTO:0004470 Hepatocellular carcinoma cell line. Marion 2010-02-04T10:03:31Z BrendaTissueOBO BTO:0004470 LM6 cell BTO:0004472 Mantle cell lymphoma is one of the rarest of the non-Hodgkin's lymphomas, comprising about 6% of NHL cases. It is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. Marion 2010-02-04T10:18:47Z BrendaTissueOBO MCL cell BTO:0004472 mantle cell lymphoma cell BTO:0004475 Murine erythroleukemia cell line. Marion 2010-02-04T10:43:43Z BrendaTissueOBO BTO:0004475 MEL cell BTO:0004479 Human acute myelocytic leukemia cell line. Marion 2010-02-04T11:07:29Z BrendaTissueOBO BTO:0004479 MV4-11 cell BTO:0004482 Marion 2010-02-04T12:00:49Z BrendaTissueOBO OSE cell BTO:0004482 ovarian surface epithelial cell line BTO:0004483 Marion 2010-02-04T12:03:36Z BrendaTissueOBO BTO:0004483 ovarian surface epithelium BTO:0004489 Esophageal cancer cell line. Marion 2010-02-04T05:19:45Z BrendaTissueOBO OE21 cell BTO:0004489 OE-21 cell BTO:0004493 Marion 2010-02-04T05:39:24Z BrendaTissueOBO gastric epithelial cell line BTO:0004493 gastric epithelium cell line BTO:0004494 Normal rat gastric epithelial cell line. Marion 2010-02-04T05:39:49Z BrendaTissueOBO BTO:0004494 RGM-1 cell BTO:0004496 Precursors of an osteoclast. Marion 2010-02-04T05:56:25Z BrendaTissueOBO BTO:0004496 preosteoclast BTO:0004499 Prostatic intraepithelial neoplasia (PIN) is a microscopic lesion in the prostate which is thought to be a precursor to prostate cancer. Marion 2010-02-08T12:08:40Z BrendaTissueOBO PIN cell PIN cell line prostate intraepithelial neoplasia cell line prostatic intraepithelial neoplasia cell line BTO:0004499 prostate gland intraepithelial neoplasia cell line BTO:0004500 Mouse embryonic stem cell line; established from a 3.5 day blastocyst produced by crossing two 129 substrains, 129S1/SvImJ and 129X1/SvJ. Marion 2010-02-08T12:27:38Z BrendaTissueOBO R1 ES cell BTO:0004500 R1 cell BTO:0004502 Cambium that produces secondary phloem on its outer side and secondary xylem on its inner side. Marion 2010-02-08T12:48:00Z BrendaTissueOBO BTO:0004502 vascular cambium BTO:0004508 A tumor developing from endothelial tissue. mgr 2010-02-08T04:41:49Z BrendaTissueOBO BTO:0004508 endothelioma cell BTO:0004513 mgr 2010-02-11T09:38:15Z BrendaTissueOBO BTO:0004513 Sertoli cell line BTO:0004518 Simple or branched, tubular gland extending into the lamina propria-submucosa, secreting mucus, lipids, glycogen, protein. mgr 2010-02-11T10:19:34Z BrendaTissueOBO BTO:0004518 uterine gland BTO:0004520 Regulatory T cells are a specialized subpopulation of T cells that act to suppress activation of the immune system and thereby maintain immune system homeostasis and tolerance to self-antigens. mgr 2010-02-11T10:28:02Z BrendaTissueOBO T suppressor cell Treg cell Ts cell regulatory T-cell suppressor T-cell suppressor T-lymphocyte BTO:0004520 regulatory T-lymphocyte BTO:0004522 mgr 2010-02-11T08:07:47Z BrendaTissueOBO BTO:0004522 Leydig cell line BTO:0004523 Mouse Leydig cell line. mgr 2010-02-11T08:09:27Z BrendaTissueOBO TM3 cell BTO:0004523 TM-3 cell BTO:0004524 Epithelium covering the embryonic genital ridges and the gonads that develop from them. mgr 2010-02-11T08:34:59Z BrendaTissueOBO surface epithelium BTO:0004524 germinal epithelium BTO:0004528 Specialized area of vascular endothelium found in lymphoid organs, which express a variety of cell-adhesion molecules and is involved in lymphocyte extravasation. mgr 2010-02-13T05:53:27Z BrendaTissueOBO HEV cell BTO:0004528 high endothelial venule BTO:0004537 The cortical collecting ducts receive filtrate from multiple initial collecting tubules and descend into the renal medulla to form medullary collecting ducts. mgr 2010-02-16T10:29:18Z BrendaTissueOBO CCD cell BTO:0004537 cortical collecting duct cell BTO:0004539 With respect to the renal corpuscle, the connecting tubule is the most proximal part of the collecting duct system. It is adjacent to the distal convoluted tubule, the most distal segment of the renal tubule. Connecting tubules from several adjacent nephrons merge to form cortical collecting tubules, and these may join to form cortical collecting ducts. Connecting tubules of some juxtamedullary nephrons may arch upward, forming an arcade. The connecting tubule derives from the metanephric blastema, but the rest of the system derives from the ureteric bud. Because of this, some sources group the connecting tubule as part of the nephron, rather than grouping it with the collecting duct system. mgr 2010-02-16T10:31:31Z BrendaTissueOBO BTO:0004539 connecting tubule BTO:0004546 mgr 2010-02-16T11:03:49Z BrendaTissueOBO HSCC cell BTO:0004546 hypopharyngeal squamous cell carcinoma cell line BTO:0004547 mgr 2010-02-16T11:05:49Z BrendaTissueOBO BTO:0004547 hypopharyngeal squamous cell carcinoma cell BTO:0004560 Histologically, the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin. mgr 2010-02-16T08:05:49Z BrendaTissueOBO medulla of thymus thymus medulla BTO:0004560 thymic medulla BTO:0004561 Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin. mgr 2010-02-16T08:07:21Z BrendaTissueOBO BTO:0004561 thymic stromal cell BTO:0004569 The ovarian fluid surrounds eggs from female fish. mgr 2010-02-17T10:23:59Z BrendaTissueOBO BTO:0004569 ovarian fluid BTO:0004574 mgr 2010-04-11T11:11:39Z BrendaTissueOBO DMEC cell BTO:0004574 dermal microvascular endothelial cell BTO:0004580 Mouse pheochromocytoma cell line. mgr 2010-04-12T10:32:38Z BrendaTissueOBO BTO:0004580 862L cell BTO:0004585 A subtype of acute myelogenous leukemia (AML), a cancer of the blood and bone marrow. In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes. mgr 2010-04-12T10:58:54Z BrendaTissueOBO APL cell acute progranulocytic leukemia cell BTO:0004585 acute promyelocytic leukemia cell BTO:0004586 A young fish; especially: a newly hatched salmon when still attached to the yolk sac. mgr 2010-04-12T11:02:54Z BrendaTissueOBO BTO:0004586 alevin BTO:0004592 The intercellular substance of bone tissue consisting of collagen fibers, ground substance, and inorganic bone salts. mgr 2010-04-12T07:56:37Z BrendaTissueOBO BTO:0004592 bone matrix BTO:0004602 Human aortic endothelial cell line. mgr 2010-04-13T09:34:08Z BrendaTissueOBO HAEC cell BTO:0004602 human aortic endothelial cell BTO:0004605 Human neuronal glioblastoma (grade III) cell line. XPMUser 2011-02-25T08:22:30Z BrendaTissueOBO U-118 MG cell U-118 cell BTO:0004605 U-118MG cell BTO:0004607 Cell line was derived by cloning the parental cell line MDCK. mgr 2010-04-13T10:58:41Z BrendaTissueOBO MDCK II cell MDCK.2 cell MDCK2 cell BTO:0004607 MDCK-2 cell BTO:0004608 The long U-shaped part of the renal tubule, extending through the medulla from the end of the proximal convoluted tubule. It begins with a descending limb comprising the proximal straight tubule and the thin tubule, followed by the ascending limb the distal straight tubule, and ending at the distal convoluted tubule. mgr 2010-04-13T11:09:09Z BrendaTissueOBO loop of Henle BTO:0004608 Henles loop BTO:0004617 A gelatinous substance of various plants (as legumes or seaweeds) that contains protein and polysaccharides and is similar to plant gums . XPMUser 2011-03-07T08:23:33Z BrendaTissueOBO BTO:0004617 mucilage BTO:0004621 Human acute myeloid leukemia cell line; established from the peripheral blood of a 77-year-old man with acute myeloid leukemia. mgr 2010-04-13T09:22:50Z BrendaTissueOBO OCI AML5 cell OCI-AML-5 cell OCI/AML-5 cell BTO:0004621 OCI-AML5 cell BTO:0004628 One of the four valves in the heart, this valve is situated at exit of the left ventricle of the heart where the aorta begins. The aortic valve lets blood from the left ventricle be pumped up into the aorta but prevents blood once it is in the aorta from returning to the heart. mgr 2010-04-14T09:22:13Z BrendaTissueOBO BTO:0004628 aortic valve BTO:0004630 mgr 2010-04-14T09:45:07Z BrendaTissueOBO BTO:0004630 middle midgut BTO:0004640 Farber disease dermal fibroblast cell line. XPMUser 2013-03-15T12:57:07Z BrendaTissueOBO GM20017 cell BTO:0004640 FD-2 cell BTO:0004641 mgr 2010-04-16T09:16:55Z BrendaTissueOBO BTO:0004641 tracheal cell line BTO:0004649 An external membranous process of an aquatic animal as a fish used in propelling or guiding the body. mgr 2010-05-05T08:09:22Z BrendaTissueOBO BTO:0004649 fin BTO:0004650 The unpaired fin located on the back of both bony fish and sharks. It may be single and soft-rayed, as in trout, or double with the anterior dorsal fin supported by fin spines, as in perch. In some species, e.g. eels, the dorsal fin is confluent with the tail fin. mgr 2010-05-05T08:09:41Z BrendaTissueOBO BTO:0004650 dorsal fin BTO:0004653 In fish, one of the pair of fins that are situated one on each side of the fish just behind the gills. Normally they are used for balancing and braking, but in some species, e.g. Exocoetidae, flying fish, the extra-large fins are used for jumping and for gliding over the water surface. mgr 2010-05-05T08:10:42Z BrendaTissueOBO BTO:0004653 pectoral fin BTO:0004659 Exoskeleton or shell, including those of mollusks, turtles, insects and crustaceans. mgr 2010-05-05T09:24:54Z BrendaTissueOBO shell BTO:0004659 exoskeleton BTO:0004669 Any of the five terminating members of the hand, a digit of the forelimb. mgr 2010-05-10T12:30:15Z BrendaTissueOBO digit forelimb digit BTO:0004669 finger BTO:0004672 The non-growing portion of a hair which protrudes from the skin, i.e., from the follicle. mgr 2010-05-10T12:51:05Z BrendaTissueOBO scapus pili BTO:0004672 hair shaft BTO:0004676 Either of two large bundles of nerve fibers passing from the pons forward and outward to form the main connection between the cerebral hemispheres and the spinal cord. mgr 2010-05-12T01:08:56Z BrendaTissueOBO BTO:0004676 cerebral peduncle BTO:0004684 A small opening on the side of the head in some gastropods through which the penis is protruded. mgr 2010-05-14T09:29:04Z BrendaTissueOBO genital orifice BTO:0004684 genital pore BTO:0004687 The bony socket of the eye. mgr 2010-05-14T09:56:53Z BrendaTissueOBO BTO:0004687 orbit BTO:0004689 External gills are the gills of an animal, most typically an amphibian, that are exposed to the environment, rather than set inside the pharynx and covered by gill slits, as they are in most fishes. mgr 2010-05-14T10:12:08Z BrendaTissueOBO BTO:0004689 external gill BTO:0004692 A system of interconnected blood vessels that returns blood to the heart from the tissue and capillary bed through progressively larger vessels. mgr 2010-05-14T10:46:00Z BrendaTissueOBO BTO:0004692 venous system BTO:0004694 The enlarged anterior part of the rectum, sometimes produced into a large rectal caecum. mgr 2010-05-14T11:49:59Z BrendaTissueOBO BTO:0004694 rectal sac BTO:0004696 In human anatomy, the external carotid artery is a major artery of the head and neck. It arises from the common carotid artery when it bifurcates into the external and internal carotid artery. mgr 2010-05-14T01:56:27Z BrendaTissueOBO BTO:0004696 external carotid artery BTO:0004699 mgr 2010-05-16T09:08:26Z BrendaTissueOBO BTO:0004699 posterior pharynx BTO:0004716 A null cell is a large granular lymphocyte without surface markers or membrane-associated proteins from B lymphocytes or T lymphocytes. Members of null cells are natural killer cells, antigen dependent cytotoxic cells and the lymphokine activated killer cells. mgr 2010-05-18T11:33:17Z BrendaTissueOBO BTO:0004716 null cell BTO:0004717 A type of white blood cell that contains granules with enzymes that can kill tumor cells or microbial cells. mgr 2010-05-18T11:40:56Z BrendaTissueOBO BTO:0004717 large granular lymphocyte BTO:0004719 The H-shaped excretory cell is the largest cell in Caenorabditis elegans. mgr 2010-05-18T12:40:54Z BrendaTissueOBO excretory canal cell BTO:0004719 excretory canal BTO:0004720 A nonendothelial cell enclosed within the basement membrane of retinal capillaries. mgr 2010-07-22T10:21:53Z BrendaTissueOBO BTO:0004720 mural cell BTO:0004721 The most common division of dendritic cells is myeloid versus plasmacytoid. The myeloid dendritic cells are developed from myeloid precursors and are most similar to monocytes. They are made up of at least two subsets: 1. the more common mDC-1, which is a major stimulator of T cells and 2. the extremely rare mDC-2, which may have a function in fighting wound infection. They secrete IL-12. mgr 2010-07-23T09:04:22Z BrendaTissueOBO mDC cell BTO:0004721 myeloid dendritic cell BTO:0004725 mgr 2010-08-20T08:25:19Z BrendaTissueOBO BTO:0004725 embryonic fibroblast BTO:0004726 mgr 2010-08-20T08:29:57Z BrendaTissueOBO BTO:0004726 embryonic brain BTO:0004729 Peripheral blood lymphocytes are mature lymphocytes that circulate in the blood, rather than localising to organs, such as the spleen or lymph nodes. They comprise T cells, NK cells and B cells. mgr 2010-08-20T09:27:43Z BrendaTissueOBO PBL cell BTO:0004729 peripheral blood lymphocyte BTO:0004730 One of the two stem cells derived from hematopoietic stem cells, the other being the lymphoid progenitor cell. Derived from these myeloid progenitor cells are the erythroid progenitor cells and the myeloid cells. mgr 2010-08-20T09:34:28Z BrendaTissueOBO BTO:0004730 myeloid progenitor cell BTO:0004731 One of the two stem cells derived from hematopoietic stem cells, the other being the myeloid progenitor cell. Derived from these myeloid progenitor cells are the erythroid progenitor cells and the myeloid cells. mgr 2010-08-20T09:36:51Z BrendaTissueOBO BTO:0004731 lymphoid progenitor cell BTO:0004736 Human papillary thyroid carcinoma derived cell line. mgr 2010-09-29T08:47:36Z BrendaTissueOBO BCPAP cell BTO:0004736 B-CPAP cell BTO:0004738 This line was derived from a pancreatic duct adenocarcinoma (liver metastasis) from a patient with cystic fibrosis. mgr 2010-09-29T08:55:53Z BrendaTissueOBO CF-PAC-1 cell CFPAC cell CFPAC1 cell BTO:0004738 CFPAC-1 cell BTO:0004744 Hair cells are the sensory receptors of both the auditory system and the vestibular system in all vertebrates. In mammals, the auditory hair cells are located within the organ of Corti on a thin basilar membrane in the cochlea of the inner ear. mgr 2010-09-29T09:36:28Z BrendaTissueOBO BTO:0004744 hair cell BTO:0004757 mgr 2010-09-30T10:33:17Z BrendaTissueOBO BTO:0004757 arterial endothelium BTO:0004760 Human bone marrow erythroleukemia cell line. The TF-1 cell line has been established in October 1987 from a heparinized bone marrow aspiration sample from a 35 year old Japanese male with severe pancytopenia. mgr 2010-09-30T10:40:21Z BrendaTissueOBO BTO:0004760 TF-1 cell BTO:0004765 Acute myeloid leukemia cell line. mgr 2010-10-02T10:22:54Z BrendaTissueOBO BTO:0004765 UKE-1 cell BTO:0004766 Acute myeloid leukemia cell line. Human essential thrombocythemia cell line; established from the peripheral blood of a 71-year-old woman with essential thrombocythemia at megakaryoblastic leukemic transformation. mgr 2010-10-02T10:24:42Z BrendaTissueOBO BTO:0004766 SET-2 cell BTO:0004771 Papillary thyroid tumor cell line. mgr 2010-10-02T11:01:58Z BrendaTissueOBO BTO:0004771 NPA cell BTO:0004772 Follicular thyroid tumor cell line. mgr 2010-10-02T11:03:05Z BrendaTissueOBO BTO:0004772 WRO cell BTO:0004774 Tanaka et al have reported that a culture of mouse blastocysts or early postimplantation trophoblasts in the presence of FGF-4 permits the isolation of permanent trophoblast stem cell lines. mgr 2010-10-02T11:14:22Z BrendaTissueOBO TS cell BTO:0004774 trophoblast stem cell BTO:0004778 A special type of inhibitory cells representing approximately 90% of the neurons within the corpus striatum of the basal ganglia. They play a key role in initiating and controlling movements of the body, limbs and eyes. mgr 2010-10-04T08:55:16Z BrendaTissueOBO MSN medium-sized densely spiny neuron spiny projection neuron BTO:0004778 medium spiny neuron BTO:0004779 A malignant tumor that begins in the muscle, fat, fibrous tissue, blood vessels, or other "soft" supporting tissues of the body. Soft tissue sarcomas do not originate in bone or cartilage. mgr 2010-10-04T08:59:10Z BrendaTissueOBO BTO:0004779 soft tissue sarcoma cell BTO:0004782 Human neuroblastoma cell line. mgr 2010-10-04T09:13:35Z BrendaTissueOBO BE(2)C cell SK-N-BE(2)-C cell BTO:0004782 SK-N-BE(2)C cell BTO:0004785 Ewing sarcoma family of tumors (ESFT) belong to the group of neoplasms commonly referred to as small, round, blue-cell tumors of childhood. mgr 2010-10-04T09:40:39Z BrendaTissueOBO ESFT cell line BTO:0004785 Ewing's sarcoma family tumor cell line BTO:0004787 Ewing's sarcoma family tumor cell line. mgr 2010-10-04T09:52:54Z BrendaTissueOBO BTO:0004787 SK-N-LO cell BTO:0004796 Human bladder transitional cell carcinoma cell line. mgr 2010-10-05T09:27:24Z BrendaTissueOBO BTO:0004796 253J cell BTO:0004798 Male accessory glands in humans are the seminal vesicles, prostate gland, and the bulbourethral glands. In insects, male accessory glands produce products that mix with the sperm to protect and preserve them. mgr 2010-10-05T09:32:58Z BrendaTissueOBO male accessory gland BTO:0004798 accessory sex gland BTO:0004799 A prostate cancer cell line, that proliferates under androgen-depleted conditions after emerging from long-term, androgen- depleted culture of the androgen-sensitive prostate cancer cell line LNCaP. mgr 2010-10-05T09:39:11Z BrendaTissueOBO BTO:0004799 AILNCaP cell BTO:0004800 The amnioserosa is an extraembryonic, epithelial tissue that covers the dorsal side of the Drosophila embryo. mgr 2010-10-05T09:52:00Z BrendaTissueOBO amnion-serosa BTO:0004800 amnioserosa BTO:0004814 Chicken B cell line; established in 1985 from a bursal lymphoma, which was induced by infection of a 1 day old chicken with Rous-associated virus type 1 (RAV-1), an avian leukosis retrovirus carrying no cell-derived oncogene. mgr 2010-10-05T11:47:40Z BrendaTissueOBO DT 40 cell DT-40B cell DT40 cell DT40B cell BTO:0004814 DT-40 cell BTO:0004830 mgr 2010-10-05T05:04:25Z BrendaTissueOBO BTO:0004830 epidermal cell line BTO:0004850 The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells. mgr 2010-10-08T12:44:00Z BrendaTissueOBO BTO:0004850 bone marrow cell BTO:0004857 A motile zygote in various protozoans (as the malaria parasite). XPMUser 2011-02-25T09:46:12Z BrendaTissueOBO BTO:0004857 ookinete BTO:0004858 Human anaplastic thyroid carcinoma cell line. mgr 2010-10-11T02:12:47Z BrendaTissueOBO BTO:0004858 ACT-1 cell BTO:0004859 Human thyroid follicular epithelial cell line. mgr 2010-10-11T02:42:52Z BrendaTissueOBO NTHY-Ori-3-1 cell Nthy ori 3.1 cell Nthy-ori 3.1 cell BTO:0004859 Nthy-ori 3-1 cell BTO:0004860 Human glioblastoma cell line. mgr 2010-10-11T02:49:33Z BrendaTissueOBO BTO:0004860 GaMG cell BTO:0004868 An aggressive (rapidly progressing) type of non-Hodgkins lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver. mgr 2010-10-11T03:55:47Z BrendaTissueOBO ALCL cell line BTO:0004868 anaplastic large cell lymphoma cell line BTO:0004876 The reproductive tract in the hermaphroditic nematode has two equivalent gonad arms. As it grows longer, that portion lying closer to the gonopore (vulva or cloaca) is termed the proximal arm, while the distal arm lies further away with the extreme end named the distal tip. mgr 2010-10-12T10:33:18Z BrendaTissueOBO BTO:0004876 distal tip BTO:0004901 Cell pertaining to or composed of nonconducting cells of the nervous system, e.g. neuroglial cells. mgr 2010-10-14T11:19:48Z BrendaTissueOBO nonneuronal cell BTO:0004901 non-neuronal cell BTO:0004909 The cerebellar cortex is divided into three layers. At the bottom lies the thick granular layer. In the middle lies the Purkinje layer, a narrow zone that contains only the cell bodies of Purkinje cells. At the top lies the molecular layer. mgr 2010-10-14T12:52:12Z BrendaTissueOBO Purkinje cell layer BTO:0004909 Purkinje layer BTO:0004911 Committed, erythroid stem cells derived from myeloid stem cells. The progenitor cells develop in two phases: erythroid burst-forming units (bfu-e) followed by erythroid colony-forming units (cfu-e). Bfu-e differentiate into cfu-e on stimulation by erythropoietin, and then further differentiate into erythroblasts when stimulated by other factors. marion 2010-10-25T05:15:19Z BrendaTissueOBO BTO:0004911 erythroid progenitor cell BTO:0004915 Human mammary gland ductal carcinoma cell line; derived from malignant ascites fluid from a 47-year-old premenopausal Black woman with infiltrating ductal carcinoma. Marion Gremse 2010-10-27T10:23:56Z BrendaTissueOBO ZR75-30 cell BTO:0004915 ZR-75-30 cell BTO:0004958 The yeast genomic DNA from the strain F9 was transferred to the established mouse fibroblast cell line L A-9 by fusion with yeast spheroplasts followed by selection with G418 to select for cells which had taken up yeast DNA. Seventeen independent cell lines, called F9-1 to F9-17, were grown up from colonies on separate plates. Marion Gremse 2010-10-28T12:29:08Z BrendaTissueOBO BTO:0004958 F9-12 cell BTO:0004972 Human Hodgkin lymphoma cell line, established from the pleural effusion of a 37-year-old man with Hodgkin lymphoma (mixed cellularity progressing to lymphocyte depletion; stage IV at relapse) in 1974. Marion Gremse 2010-10-28T01:34:23Z BrendaTissueOBO KMH2 cell BTO:0004972 KM-H2 cell BTO:0004973 A disease of the lymph nodes named after the English physician Thomas Hodgkin. Marion Gremse 2010-10-28T01:35:51Z BrendaTissueOBO BTO:0004973 Hodgkin lymphoma cell line BTO:0004974 A disease of the lymph nodes named after the English physician Thomas Hodgkin. Marion Gremse 2010-10-28T01:37:17Z BrendaTissueOBO BTO:0004974 Hodgkin lymphoma cell BTO:0004977 Fluid obtained by irrigation or washout of the nasal cavity and nasal mucosa. XPMUser 2011-02-25T09:53:31Z BrendaTissueOBO nasal lavage BTO:0004977 nasal lavage fluid BTO:0004978 Carotid branch of glossopharyngeal nerve. XPMUser 2011-02-26T10:41:33Z BrendaTissueOBO BTO:0004978 carotid sinus nerve BTO:0004979 The glossopharyngeal nerve is the ninth (IX) of twelve pairs of cranial nerves. It exits the brainstem out from the sides of the upper medulla, just rostral (closer to the nose) to the vagus nerve. XPMUser 2011-02-26T10:43:43Z BrendaTissueOBO cranial nerve IX BTO:0004979 glossopharyngeal nerve BTO:0004980 Ocular melanoma consisting of overgrowth of uveal melanocytes. XPMUser 2011-02-26T11:12:21Z BrendaTissueOBO BTO:0004980 uveal melanoma cell BTO:0004986 Gastric carcinoma cell line; derived in 1987 by J. Park and associates from ascites of a patient with poorly differentiated carcinoma of the stomach. XPMUser 2011-02-26T04:43:45Z BrendaTissueOBO BTO:0004986 SNU-5 cell BTO:0004991 Human transitional cell carcinoma of the renal pelvis. XPMUser 2011-02-26T05:04:41Z BrendaTissueOBO BTO:0004991 UM-UC-14 cell BTO:0004997 A variety of glial cell that keep unmyelinated peripheral nerve fibres alive. XPMUser 2011-02-26T05:35:28Z BrendaTissueOBO nonmyelinating Schwann cell BTO:0004997 non-myelinating Schwann cell BTO:0005033 Highly tumorigenic and metastatic human melanoma cell line. XPMUser 2012-08-31T03:43:15Z BrendaTissueOBO BTO:0005033 MV3 cell BTO:0005034 XPMUser 2011-03-05T10:43:04Z BrendaTissueOBO BTO:0005034 DT-40 3KO cell BTO:0005043 Human melanoma cell line. XPMUser 2011-03-05T11:45:26Z BrendaTissueOBO M1 cell BTO:0005043 M1 melanoma cell BTO:0005049 XPMUser 2011-03-05T08:56:21Z BrendaTissueOBO BTO:0005049 prostate adenocarcinoma cell line BTO:0005053 For example the midgut epithelium of Wirenia argentea Odhner Mollusca, Solenogastres) is composed of two cell types: dorsal ciliary cells and digestive cells. XPMUser 2011-03-05T09:11:07Z BrendaTissueOBO BTO:0005053 midgut epithelium BTO:0005059 TZM-bl cells are HeLa-cell derivatives that express high levels of CD4 and both co-receptors CXCR4 and CCR5, and are stably transduced carrying a LTR-driven firefly luciferase as well as a LTR-driven beta-galactosidase cassette. XPMUser 2011-03-05T09:51:34Z BrendaTissueOBO BTO:0005059 TZM-bl cell BTO:0005060 Human melanoma cell line. XPMUser 2011-03-05T09:56:22Z BrendaTissueOBO UACC 903 cell UACC903 cell BTO:0005060 UACC-903 cell BTO:0005065 An immortal line of fibroblast like cells established from whole trypsinised embryos of Swiss mice (not an inbred stock) under conditions that favour establishment of cells with low saturation density in culture. XPMUser 2011-03-07T02:01:59Z BrendaTissueOBO Swiss 3T3 cell Swiss/3T3 cell Swiss3T3 cell BTO:0005065 Swiss-3T3 cell BTO:0005067 1. Murine cutaneous squamous cell carcinoma cell line. 2. Murine keratinocyte cell line. XPMUser 2011-03-07T02:37:15Z BrendaTissueOBO PAM 212 cell BTO:0005067 PAM212 cell BTO:0005068 Human intestinal epithelial cell line. XPMUser 2011-03-07T02:56:04Z BrendaTissueOBO BTO:0005068 SK-CO15 cell BTO:0005071 Human prostate cancer cell line. XPMUser 2011-03-07T04:47:27Z BrendaTissueOBO BTO:0005071 PC3-MM2 cell BTO:0005078 The underside of the foot. XPMUser 2011-03-07T07:37:10Z BrendaTissueOBO BTO:0005078 foot sole BTO:0005084 Either of two pairs of folds of mucous membrane projecting into the larynx. XPMUser 2011-03-07T08:43:12Z BrendaTissueOBO Stimmband Stimmlippe plica vocalis vocal band vocal chord vocal cord BTO:0005084 vocal fold BTO:0005085 The artery that serves blood to the penis. It subdivides into three arteries, the bulbourethral artery, the dorsal artery of the penis and the cavernosal artery. XPMUser 2011-03-08T08:35:13Z BrendaTissueOBO penile artery BTO:0005085 common penile artery BTO:0005089 A dense membrane composed of fibrous connective tissue that closely wraps (invests) all cartilage, except the cartilage in joints which is covered by a synovial membrane. XPMUser 2011-03-08T09:08:36Z BrendaTissueOBO BTO:0005089 perichondrium BTO:0005093 Each component of the collecting duct system contains two cell types, intercalated cells and a segment-specific cell type. XPMUser 2011-03-08T09:40:36Z BrendaTissueOBO BTO:0005093 intercalated cell BTO:0005094 The basal part of a grass leaf that encircles the stem. XPMUser 2011-03-08T09:45:57Z BrendaTissueOBO BTO:0005094 leaf sheath BTO:0005096 Epithelial stem cells in the lining of the digestive tract occur in deep crypts and give rise to several cell types: absorptive cells, goblet cells, paneth cells, and enteroendocrine cells. XPMUser 2011-03-21T08:23:48Z BrendaTissueOBO BTO:0005096 epithelial stem cell BTO:0005097 Skin stem cells occur in the basal layer of the epidermis and at the base of hair follicles. XPMUser 2011-03-21T08:25:47Z BrendaTissueOBO BTO:0005097 skin stem cell BTO:0005098 The epidermal stem cells give rise to keratinocytes, which migrate to the surface of the skin and form a protective layer. XPMUser 2011-03-21T08:26:55Z BrendaTissueOBO BTO:0005098 epidermal stem cell BTO:0005112 This cell line was derived in 1996 from a heterogeneous 32 week primary tumor in the prostate of a PB-Tag C57BL/6 (TRAMP) mouse. XPMUser 2011-05-05T10:17:21Z BrendaTissueOBO BTO:0005112 TRAMP-C1 cell BTO:0005117 XPMUser 2011-05-05T11:09:05Z BrendaTissueOBO BTO:0005117 retinal ganglion cell line BTO:0005118 Murine retinal ganglion cell line. XPMUser 2011-05-05T11:09:36Z BrendaTissueOBO BTO:0005118 RGC-5 cell BTO:0005120 A neuroectodermal tumor is a tumor of the central or peripheral nervous system. XPMUser 2011-05-05T12:29:28Z BrendaTissueOBO BTO:0005120 neuroectodermal tumor cell BTO:0005124 The platysma is a superficial muscle that overlaps the sternocleidomastoid. XPMUser 2011-05-06T10:32:35Z BrendaTissueOBO neck platysma muscle platysma BTO:0005124 platysma muscle BTO:0005125 In human anatomy is a paired muscle in the superficial layers of the anterior portion of the neck. It acts to flex and rotate the head. XPMUser 2011-05-06T10:33:36Z BrendaTissueOBO sternocleidomastoid sternocleidomastoideus BTO:0005125 sternocleidomastoid muscle BTO:0005136 Mouse embryonic stem cell line. XPMUser 2011-05-11T10:03:05Z BrendaTissueOBO E-14 cell E14 cell BTO:0005136 ES-E14 cell BTO:0005151 One of the hornlike projections of gray matter into the white matter of the spinal cord. The anterior horn contains efferent fibers innervating skeletal muscle tissue. XPMUser 2011-08-27T02:55:27Z BrendaTissueOBO anterior column ventral column ventral horn BTO:0005151 anterior horn BTO:0005155 The CEM-VBL100 cell line is a multidrug-resistant variant of the derivative of the CCRF-CEM cell line. XPMUser 2011-08-27T03:22:14Z BrendaTissueOBO CEM-VLB100 cell CEM/VLB 100 CEM/VLB100 cell BTO:0005155 CEM-VBL100 cell BTO:0005180 A fleshy mass of thickened conjunctiva that grows over part of the cornea usually from the inner side of the eyeball and causes a disturbance of vision. XPMUser 2011-08-30T01:02:10Z BrendaTissueOBO BTO:0005180 pterygium BTO:0005182 This cell line was initiated in October of 1992 from a patient with early onset ovarian cancer. The patient was of French-Canadian descent with an unknown family history of ovarian cancer. XPMUser 2011-08-30T01:15:33Z BrendaTissueOBO BTO:0005182 TOV-112D cell BTO:0005189 The kidney of the channel catfish is completely separated into the head and trunk kidneys. The head kidney is involved in endocrine and hemopoietic functions and the trunk kidney functions primarily as part of the excretory system. XPMUser 2011-09-01T11:31:28Z BrendaTissueOBO BTO:0005189 head kidney BTO:0005194 Primary roots usually <2 mm diameter that have the function of water and nutrient uptake. They are often heavily branched and support mycorrhizas. These roots may be short lived, but are replaced by the plant in an ongoing process of root 'turnover'. XPMUser 2011-09-01T08:33:48Z BrendaTissueOBO BTO:0005194 fine root BTO:0005198 Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin e.g. adipose-derived stem cell. XPMUser 2011-09-01T09:15:43Z BrendaTissueOBO BTO:0005198 adipose-derived stem cell BTO:0005202 A small bulb that develops from an aerial bud. Bulbils are easily detached and function as a means of vegetative propagation. They may form from lateral buds, as in the lesser celandine (Ranunculus ficaria), or develop in place of flowers, as in many species of Allium. Certain forms of apomixis give rise to bulbils, as seen in the lesser bulbous saxifrage (Saxifraga cernua). The term is also applied to various outgrowths formed by lower plants that become detached and develop into new plants. For example, the fern Asplenium bulbiferum produces bulbils on the upper surface of its fronds and Lycopodium selago has bulbils in the axils of the uppermost leaves. XPMUser 2011-09-02T08:00:18Z BrendaTissueOBO BTO:0005202 bulbil BTO:0005205 Any of the arteries supplying blood to the cerebral cortex. XPMUser 2011-09-02T10:00:15Z BrendaTissueOBO BTO:0005205 cerebral artery BTO:0005206 The middle cerebral artery (MCA) is one of the three major paired arteries that supplies blood to the cerebrum. XPMUser 2011-09-02T10:01:04Z BrendaTissueOBO BTO:0005206 middle cerebral artery BTO:0005224 Human fetal osteoblast cell line. XPMUser 2011-09-03T08:47:31Z BrendaTissueOBO hFOB1.19 cell BTO:0005224 hFOB 1.19 cell BTO:0005238 Human embryonic kidney cell line stably expressing the tetracycline (Tet) repressor. XPMUser 2011-09-24T11:06:39Z BrendaTissueOBO T-REx HEK-293 cell BTO:0005238 T-REx 293 cell BTO:0005248 A subline of the M-07 human megakaryoblastic leukemia cell line. XPMUser 2011-10-01T10:14:39Z BrendaTissueOBO M-O7E cell M07E cell MO7E cell BTO:0005248 M-07E cell BTO:0005250 Human nasopharyngeal carcinoma cell line. XPMUser 2011-10-01T10:36:48Z BrendaTissueOBO CNE2 cell BTO:0005250 CNE-2 cell BTO:0005259 XPMUser 2011-10-03T09:15:20Z BrendaTissueOBO BTO:0005259 oropharyngeal carcinoma cell line BTO:0005261 XPMUser 2011-10-03T09:25:46Z BrendaTissueOBO BTO:0005261 B-lymphoblast cell line BTO:0005264 Mucoepidermoid carcinoma (MEC) is the most common primary salivary gland-type tumour of the lung. It arises from the excretory ducts of the bronchial mucosa. XPMUser 2011-10-05T08:46:31Z BrendaTissueOBO BTO:0005264 mucoepidermoid carcinoma cell BTO:0005277 CAG cell line; established from a bone marrow aspirate of a patient with myeloma. XPMUser 2012-02-06T11:24:05Z BrendaTissueOBO BTO:0005277 CAG cell BTO:0005288 Normal human fetal liver cell line. XPMUser 2012-02-08T08:54:24Z BrendaTissueOBO BTO:0005288 CL-48 cell BTO:0005305 The ears are female inflorescences, tightly covered over by several layers of leaves, and so closed-in by them to the stem that they do not show themselves easily until the emergence of the pale yellow silks from the leaf whorl at the end of the ear, e.g. by Zea mays. XPMUser 2012-02-13T11:04:02Z BrendaTissueOBO BTO:0005305 corn ear BTO:0005332 RWLeu4 is a chronic myelogenous leukemia cell line. XPMUser 2012-03-21T10:48:49Z BrendaTissueOBO RWLeu4 cell BTO:0005332 RWLeu-4 cell BTO:0005351 The optic vesicle after invaginating to form a 2-layered cup from which the retina and pigmented layer of the eye will develop. XPMUser 2012-03-23T09:36:35Z BrendaTissueOBO eyecup ophtalmic cup BTO:0005351 optic cup BTO:0005364 Human glioma cell line. XPMUser 2012-08-31T10:23:54Z BrendaTissueOBO D-54 MG cell D54MG cell BTO:0005364 D-54MG cell BTO:0005375 XPMUser 2012-09-01T08:01:46Z BrendaTissueOBO BTO:0005375 oral cell line BTO:0005397 The SHEP human neuroblastoma cell line was subcloned from SK-N-SH. XPMUser 2012-09-03T09:54:09Z BrendaTissueOBO SHEP cell BTO:0005397 SH-EP cell BTO:0005401 The murine placenta consists of two main fetally derived compartments: the labyrinthine zone and the junctional zone. XPMUser 2012-09-04T11:39:36Z BrendaTissueOBO BTO:0005401 junctional zone BTO:0005403 The junctional zone of the mouse placenta consists of two main trophoblast populations, spongiotrophoblasts and glycogen cells (GCs), but the development and function of both cell types are unknown. XPMUser 2012-09-04T11:41:51Z BrendaTissueOBO BTO:0005403 glycogen cell BTO:0005405 The locomotory and feeding organ, found in the larval veliger stage of bivalves. XPMUser 2012-09-04T11:53:38Z BrendaTissueOBO BTO:0005405 velum BTO:0005415 XPMUser 2012-09-20T11:38:47Z BrendaTissueOBO BTO:0005415 gastroduodenal mucosa BTO:0005425 Human lung squamous cell carcinoma cell line. XPMUser 2013-03-15T06:48:39Z BrendaTissueOBO H2170 cell BTO:0005425 NCI-H2170 cell BTO:0005426 Human neuroblastoma brain (Stage III) cell line, isolated from a 16 month old male. XPMUser 2013-03-18T04:58:01Z BrendaTissueOBO NB69 cell BTO:0005426 NB-69 cell BTO:0005436 A branched indeterminate inflorescence in which the branches are racemes, so that each flower has its own stalk attached to the branch. Oats and sorghum have panicles. XPMUser 2013-04-18T11:08:50Z BrendaTissueOBO BTO:0005436 panicle BTO:0005438 Human epithelial ovarian cancer cell line. XPMUser 2013-04-22T10:09:12Z BrendaTissueOBO BTO:0005438 HO-8910 cell BTO:0005441 Lateral roots extend horizontally from the primary root (radicle) and serve to anchor the plant securely into the soil. This branching of roots also contributes to water uptake, and facilitates the extraction of nutrients required for the growth and development of the plant. XPMUser 2013-04-23T11:36:51Z BrendaTissueOBO BTO:0005441 lateral root BTO:0005445 Epithelium of the rectum. XPMUser 2013-04-26T10:08:43Z BrendaTissueOBO rectum epithelium BTO:0005445 rectal epithelium BTO:0005452 Aedes albopictus, mosquito, Asian tiger larval cell line. XPMUser 2013-09-04T11:48:08Z BrendaTissueOBO BTO:0005452 C6/36 cell BTO:0005453 CD4, cluster of differentiation 4, is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. In humans CD4+ T helper cells are white blood cells that are an essential part of the human immune system. XPMUser 2013-09-06T09:18:55Z BrendaTissueOBO BTO:0005453 culture condition:CD4+ cell BTO:0005454 Either of the columns of erectile tissue forming the body of the clitoris or penis. XPMUser 2013-09-06T09:39:31Z BrendaTissueOBO BTO:0005454 corpus cavernosum BTO:0005463 Huh-7.5.1 cells were derived from the Huh-7.5 GFP-HCV replicon cell line I/5A-GFP-6. XPMUser 2013-09-08T09:56:13Z BrendaTissueOBO BTO:0005463 Huh-7.5.1 cell BTO:0005491 Acute myelogenous leukemia-derived cell line. XPMUser 2013-09-11T09:00:47Z BrendaTissueOBO M0-91 cell M091 cell MO91 cell BTO:0005491 MO-91 cell BTO:0005492 Human lymphoblastic T-lymphocyte cell line, carrying the human T-cell leukemia virus type I. XPMUser 2013-09-11T09:05:17Z BrendaTissueOBO MT2 cell BTO:0005492 MT-2 cell BTO:0005493 Mink fetal lung cell line, derived from trypsinised lungs of several foetuses of Aleutian mink. XPMUser 2013-09-11T09:11:37Z BrendaTissueOBO Mv 1 Lu cell Mv.1.Lu cell NBL-7 cell BTO:0005493 Mv1Lu cell BTO:0005499 Human small cell lung cancer cell line. XPMUser 2013-09-11T09:42:44Z BrendaTissueOBO BTO:0005499 NYH cell BTO:0005500 Human pancreatic neuroendocrine tumor cell line. XPMUser 2013-09-12T12:17:54Z BrendaTissueOBO QGP1 cell BTO:0005500 QGP-1 cell BTO:0005514 In Caenorhabditis elegans, specialized contractile myoepithelial cells of the somatic gonad, the gonadal sheath cells, are closely apposed to oocytes and are required for normal meiotic maturation and ovulation. Marion 2013-10-16T12:51:49Z BrendaTissueOBO BTO:0005514 gonadal sheath cell BTO:0005518 A cell line derived from human lung adenocarcinoma. Marion 2013-10-16T14:34:08Z BrendaTissueOBO PC9 cell BTO:0005518 PC-9 cell BTO:0005525 A cell or organ in its initial stage of development. Marion 2013-11-06T10:48:14Z BrendaTissueOBO BTO:0005525 plant primordium BTO:0005545 Marion 2014-02-21T16:49:05Z BrendaTissueOBO kidney epithelial cell BTO:0005545 renal epithelial cell BTO:0005552 Vertebral end plates are the top and bottom portions of the vertebral bodies that interface with the vertebral discs. The vertebral end plate is composed of a layer of thickened cancellous bone. Marion 2014-02-26T14:51:05Z BrendaTissueOBO BTO:0005552 vertebral endplate BTO:0005560 Mouse embryonic fibroblast cell line oncogenically transformed with both E1A and ras, and containing wild-type p53. Marion 2014-02-26T15:50:57Z BrendaTissueOBO C8 cell BTO:0005560 C8-MEF cell BTO:0005561 Mouse embryonic fibroblast cell line oncogenically transformed with both E1A and ras, and containing p53-/-. Marion 2014-02-26T15:53:01Z BrendaTissueOBO C9 cell BTO:0005561 C9-MEF cell BTO:0005565 The embryonic tracheal system or the fruitfly is an epithelial tubular network established from defined sets of ectodermal precursor cells. Marion 2014-03-01T18:31:56Z BrendaTissueOBO larval tracheal system BTO:0005565 embryonic tracheal system BTO:0005576 A passage about one and one half inches (4 cm) long that lies parallel to and a half inch above the inguinal ligament. In the male it is the passage through which the testis descends into the scrotum and in which the spermatic cord lies - called also spermatic canal. In the female the passage is accommodating the round ligament. Marion 2014-03-02T20:47:38Z BrendaTissueOBO BTO:0005576 inguinal canal BTO:0005577 Marion 2014-03-02T21:08:31Z BrendaTissueOBO BTO:0005577 lung disease specific cell type BTO:0005578 Lymphangioleiomyomatosis is a rare lung disease that results in a proliferation of disorderly smooth muscle growth (leiomyoma) throughout the lungs, in the bronchioles, alveolar septa, perivascular spaces, and lymphatics, resulting in the obstruction of small airways (leading to pulmonary cyst formation and pneumothorax) and lymphatics (leading to chylous pleural effusion). Marion 2014-03-02T21:08:53Z BrendaTissueOBO LAM cell BTO:0005578 lymphangioleiomyomatosis disease specific cell type BTO:0005583 Marion 2014-03-05T19:34:41Z BrendaTissueOBO BTO:0005583 promonocytic leukemia cell line BTO:0005586 Marion 2014-03-05T19:59:16Z BrendaTissueOBO BTO:0005586 polar cell BTO:0005587 Marion 2014-03-05T19:59:34Z BrendaTissueOBO BTO:0005587 stalk cell BTO:0005588 A peg cell is a non-ciliated epithelial cell within the uterine tube. It is also called an intercalary cell or secretory cell. It is one of the two epithelial cells of the fallopian tube, along with ciliated simple columnar epithelial cells. Marion 2014-03-06T09:37:10Z BrendaTissueOBO intercalary oviduct cell non-ciliated oviduct cell secretory oviduct cell BTO:0005588 peg cell BTO:0005590 Marion 2014-03-06T10:42:29Z BrendaTissueOBO BTO:0005590 cervical adenocarcinoma cell line BTO:0005593 Because of the overlap between the mesocortical and the mesolimbic dopaminergic systems, they are often collectively referred to as the mesocorticolimbic system. Marion 2014-03-06T11:03:41Z BrendaTissueOBO mesocorticolimbic dopamine system BTO:0005593 mesocorticolimbic dopaminergic system BTO:0005598 Any of various flattened cells that surround seminiferous tubules. Marion 2014-03-07T10:08:57Z BrendaTissueOBO myoid cell BTO:0005598 peritubular contractile cell BTO:0005612 Highly metastatic murine melanoma overexpressing PKC delta BL6 (BL6T) and wild type (BL6) cell line. Marion 2014-03-11T17:26:29Z BrendaTissueOBO BL6 cell BTO:0005612 BL-6 cell BTO:0005630 The ganglion on the roots of the cranial nerves, containing the cell bodies of sensory neurons; The spinal ganglion. Marion 2014-04-02T10:52:35Z BrendaTissueOBO BTO:0005630 sensory ganglion BTO:0005669 NCI-H295A cells are an adherent subline of human adrenocortical carcinoma NCI-H295 cells that express all adrenal steroidogenic enzymes in a physiologically appropriate, hormonal responsive fashion. Marion 2014-09-05T08:38:16Z BrendaTissueOBO H295A cell BTO:0005669 NCI-H295A cell BTO:0005671 A steroidogenic human ovarian granulosa-like tumor cell line, from a patient with invasive ovarian granulosa cell carcinoma. Marion 2014-09-05T10:19:11Z BrendaTissueOBO BTO:0005671 KGN cell BTO:0005672 LNCaP and its derivative cell lines, which include C4-2 and the related C4-2B and CL1, are used as models of prostate cancer. Marion 2014-09-05T10:26:51Z BrendaTissueOBO C4-2 cell LNCaP-C4-2 cell BTO:0005672 LNCaP-C4-2 cell BTO:0005681 A modified root for storage of food or water, such as carrots and beets. Marion 2014-09-10T14:00:43Z BrendaTissueOBO BTO:0005681 storage root BTO:0005688 The tissue that produces all aerial parts of the plant, which include the stem as well as lateral structures, such as leaves and flowers. Marion 2014-10-21T10:32:19Z BrendaTissueOBO BTO:0005688 shoot meristem BTO:0005693 A cord of nerve tissue that is formed by union of the superior and middle trunks of the brachial plexus and that forms one of the two roots of the median nerve. Marion 2015-04-14T10:18:09Z BrendaTissueOBO lateral cord BTO:0005693 lateral nerve cord BTO:0005725 Marion 2015-04-20T09:57:36Z BrendaTissueOBO Huh7-Lunet cell Lunet cell BTO:0005725 HuH-7-Lunet cell BTO:0005729 A sensory nerve cell or sense organ, as of smell or taste, that responds to chemical stimuli. Marion 2015-04-27T09:44:25Z BrendaTissueOBO BTO:0005729 chemoreceptor cell BTO:0005736 Terminally differentiated hepatic cells derived from a human hepatic progenitor cell line that retains many characteristics of primary human hepatocytes. Marion 2015-04-27T10:07:58Z BrendaTissueOBO HepaRG cell BTO:0005736 Hepa-RG cell BTO:0005739 A type of plant cell specialized for the short-distance high-volume transport of materials. Transfer cells have numerous knobs and ridges on the inner surface of the primary cell wall. These greatly increase the surface area of the plasma membrane, which follows the contours of the protuberances. The expanded plasma membrane can accommodate a large number of transport proteins, which are responsible for transporting materials in or out of the cell. Transfer cells are found mainly in salt-secreting glands and in regions where photosynthate (sugar) is loaded or unloaded into sieve elements of phloem. Marion 2015-04-27T11:26:58Z BrendaTissueOBO BTO:0005739 transfer cell BTO:0005744 The pre-flowering stage of a plant. Marion 2015-04-27T11:57:29Z BrendaTissueOBO pre-flowering stage BTO:0005744 vegetative stage BTO:0005754 Marion 2015-09-13T14:00:56Z BrendaTissueOBO BTO:0005754 choroid plexus cancer cell BTO:0005755 Choroid plexus papillomas are an uncommon, benign neuroepithelial intraventricular tumour which can occur in both the paediatric and adult population. Marion 2015-09-13T14:01:16Z BrendaTissueOBO CPP cell BTO:0005755 choroid plexus papilloma cell BTO:0005772 Highly metastatic human ovarian cancer cell line. Marion 2015-09-28T09:29:59Z BrendaTissueOBO BTO:0005772 HO-8910PM BTO:0005784 A multinucleate mass of protoplasm produced by the merging of cells. Marion 2015-09-30T16:54:44Z BrendaTissueOBO symplasm BTO:0005784 syncytium BTO:0005788 Human neuroblastoma cell line, established from brain bone marrow tissue from a 4 years old caucasian white with neuroblastoma. Marion 2015-10-01T09:14:25Z BrendaTissueOBO BTO:0005788 SH-EP1 cell BTO:0005799 A pituitary adenoma made up predominantly of corticotrophs. Excessive corticotropin secretion may cause Cushings disease or Nelsons syndrome. Marion 2015-10-16T13:51:44Z BrendaTissueOBO ACTH-secreting adenoma cell adrenocorticotropic hormone-secreting adenoma cell corticotrop adenoma cell corticotropinoma cell BTO:0005799 corticotroph adenoma cell BTO:0005810 The bodily system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymph nodes, special deposits of lymphoid tissue (as in the gastrointestinal tract and bone marrow), macrophages, lymphocytes including the B cells and T cells, and antibodies. Marion 2015-10-20T16:30:07Z BrendaTissueOBO BTO:0005810 immune system CHEBI:10415 A polypeptide consisting of 31 amino acid residues in the sequence Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu. It is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system and results from processing of the precursor protein proopiomelanocortin (POMC). ChemIDplus:60617-12-1 CiteXplore:21044625 CiteXplore:21187108 CiteXplore:21775068 CiteXplore:22014186 CiteXplore:22080997 CiteXplore:22101356 CiteXplore:22574561 CiteXplore:22578170 CiteXplore:22626645 KEGG COMPOUND:C02210 Wikipedia:Beta-endorphin L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-threonyl-L-seryl-L-glutaminyl-L-lysyl-L-seryl-L-glutaminyl-L-threonyl-L-prolyl-L-leucyl-L-valyl-L-threonyl-L-leucyl-L-phenylalanyl-L-lysyl-L-asparaginyl-L-alanyl-L-isoleucyl-L-isoleucyl-L-lysyl-L-asparaginyl-L-alanyl-L-tyrosyl-L-lysyl-L-lysylglycyl-L-glutamine beta-Endorphin chebi_ontology CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C158H253N41O44S/c1-17-84(9)126(153(237)184-102(44-29-34-65-163)137(221)188-112(74-120(168)210)142(226)173-86(11)131(215)185-110(73-94-48-52-96(206)53-49-94)146(230)179-99(41-26-31-62-160)135(219)177-98(40-25-30-61-159)134(218)172-78-124(214)175-106(158(242)243)56-59-119(167)209)195-154(238)127(85(10)18-2)194-132(216)87(12)174-143(227)113(75-121(169)211)187-136(220)100(42-27-32-63-161)180-147(231)111(72-92-38-23-20-24-39-92)186-144(228)107(68-81(3)4)190-155(239)129(89(14)203)197-152(236)125(83(7)8)193-148(232)108(69-82(5)6)189-151(235)116-45-35-66-199(116)157(241)130(90(15)204)198-140(224)104(55-58-118(166)208)182-149(233)114(79-200)191-138(222)101(43-28-33-64-162)178-139(223)103(54-57-117(165)207)181-150(234)115(80-201)192-156(240)128(88(13)202)196-141(225)105(60-67-244-16)183-145(229)109(71-91-36-21-19-22-37-91)176-123(213)77-170-122(212)76-171-133(217)97(164)70-93-46-50-95(205)51-47-93/h19-24,36-39,46-53,81-90,97-116,125-130,200-206H,17-18,25-35,40-45,54-80,159-164H2,1-16H3,(H2,165,207)(H2,166,208)(H2,167,209)(H2,168,210)(H2,169,211)(H,170,212)(H,171,217)(H,172,218)(H,173,226)(H,174,227)(H,175,214)(H,176,213)(H,177,219)(H,178,223)(H,179,230)(H,180,231)(H,181,234)(H,182,233)(H,183,229)(H,184,237)(H,185,215)(H,186,228)(H,187,220)(H,188,221)(H,189,235)(H,190,239)(H,191,222)(H,192,240)(H,193,232)(H,194,216)(H,195,238)(H,196,225)(H,197,236)(H,198,224)(H,242,243)/t84-,85-,86-,87-,88+,89+,90+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,125-,126-,127-,128-,129-,130-/m0/s1 Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu C158H253N41O44S WOPZMFQRCBYPJU-NTXHZHDSSA-N CHEBI:10415 Beta-endorphin beta-endorphin CHEBI:10415 CHEBI:116390 1-chloro-2-[2-(2-methoxy-4-methylphenoxy)ethoxy]-4-methylbenzene CHEBI:133068 An eight-membered oligopeptide comprising Arg, Pro, Pro, Gly, Phe, Ser, Pro and Phe residues joined in sequence. It is an analogue of bradykinin lacking the Arg residue at position 9. CAS:15958-92-6 PMID:23318500 PMID:23742018 Reaxys:10326223 Reaxys:4228002 L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanine chebi_ontology 0 1-8-Bradykinin 9-De-arg-bradykinin 9-Des-arg-BK 9-de-L-Argininebradykinin 903.460 904.025 Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe Bradykinin, des-arg(9) C(=N)(NCCC[C@@H](C(=O)N1[C@H](C(N2[C@H](C(=O)NCC(N[C@H](C(N[C@H](C(=O)N3[C@H](C(=O)N[C@H](C(O)=O)CC=4C=CC=CC4)CCC3)CO)=O)CC=5C=CC=CC5)=O)CCC2)=O)CCC1)N)N C44H61N11O10 Des-arg(9)-bradykinin InChI=1S/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)/t29-,30-,31-,32-,33-,34-,35-/m0/s1 L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe RPPGFSPF VCEHWDBVPZFHAG-POFDKVPJSA-N CHEBI:133068 [des-Arg(9)]-bradykinin CHEBI:133068 CHEBI:15355 Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter. CHEBI:12686 CHEBI:13715 CHEBI:22197 CHEBI:2416 CHEBI:40559 ChemIDplus:1764436 ChemIDplus:51-84-3 CiteXplore:11228162 CiteXplore:11348607 CiteXplore:14698651 CiteXplore:14764638 CiteXplore:15008956 CiteXplore:15013569 CiteXplore:15014918 CiteXplore:15210062 CiteXplore:15231705 CiteXplore:15288882 CiteXplore:15361288 CiteXplore:15556286 CiteXplore:15675987 CiteXplore:15894309 CiteXplore:16275899 CiteXplore:16362770 CiteXplore:17011181 CiteXplore:17284361 CiteXplore:18050502 CiteXplore:18407448 CiteXplore:19255787 CiteXplore:20963497 CiteXplore:21130809 CiteXplore:21246223 CiteXplore:21545631 CiteXplore:21601579 CiteXplore:8331294 CiteXplore:8500722 DrugBank:DB03128 Gmelin:326108 HMDB:HMDB00895 KEGG COMPOUND:51-84-3 KEGG COMPOUND:C01996 MetaCyc:ACETYLCHOLINE PDBeChem:ACH Wikipedia:Acetylcholine 2-acetyloxy-N,N,N-trimethylethanaminium ACETYLCHOLINE Acetylcholine acetylcholine chebi_ontology InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 2-(acetyloxy)-N,N,N-trimethylethanaminium 2-acetoxyethyl(trimethyl)ammonium 2-acetyloxyethyl(trimethyl)ammonium 2-acetyloxyethyl(trimethyl)azanium ACh Acetyl choline ion Acetylcholine cation Acetylcholinium: acetyl-Choline Azetylcholin C7H16NO2 CC(=O)OCC[N+](C)(C)C Choline acetate (ester) O-Acetylcholine OIPILFWXSMYKGL-UHFFFAOYSA-N [2-(acetyloxy)ethyl]trimethylazanium choline acetate CHEBI:15355 Acetylcholine acetylcholine CHEBI:15355 CHEBI:15422 An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways. CHEBI:10789 CHEBI:10841 CHEBI:13236 CHEBI:22249 CHEBI:2359 CHEBI:40938 Beilstein:73010 ChemIDplus:56-65-5 CiteXplore:11157473 CiteXplore:11743516 CiteXplore:12137852 CiteXplore:14696970 CiteXplore:14707763 CiteXplore:15013648 CiteXplore:15129319 CiteXplore:15490415 CiteXplore:15882454 CiteXplore:15993662 CiteXplore:16439602 CiteXplore:2737369 CiteXplore:3338588 CiteXplore:7683296 CiteXplore:7836519 CiteXplore:8882021 DrugBank:DB00171 Gmelin:34857 HMDB:HMDB00538 KEGG COMPOUND:56-65-5 KEGG COMPOUND:C00002 KEGG DRUG:D08646 KNApSAcK:C00001491 MetaCyc:ATP PDBeChem:ATP Patent:US3079379 Reaxys:73010 Wikipedia:Adenosine triphosphate Wikipedia:Adenosine_triphosphate ATP adenosine 5'-(tetrahydrogen triphosphate) chebi_ontology ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O [[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid [[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid 5'-(Tetrahydrogen triphosphate) Adenosine 5'-ATP ADENOSINE-5'-TRIPHOSPHATE Adenosine 5'-triphosphate Adenosine 5'-triphosphorate Adenosine 5'-triphosphoric acid Adenosine triphosphate Adenylpyrophosphorate Adenylpyrophosphoric acid Adephos Adetol Adynol Atipi Atriphos C10H16N5O13P3 Cardenosine Fosfobion Glucobasin H4atp Myotriphos Phosphobion Striadyne Triadenyl Triphosphaden Triphosphoric acid adenosine ester ZKHQWZAMYRWXGA-KQYNXXCUSA-N adenosine 5'-(tetrahydrogen triphosphate) CHEBI:15422 ATP CHEBI:15422 CHEBI:15428 The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain. CHEBI:10792 CHEBI:14344 CHEBI:24368 CHEBI:42964 CHEBI:5460 Beilstein:635782 ChemIDplus:56-40-6 CiteXplore:10930630 CiteXplore:11019925 CiteXplore:11159884 CiteXplore:11174716 CiteXplore:11542461 CiteXplore:11569574 CiteXplore:11806864 CiteXplore:12097436 CiteXplore:12297216 CiteXplore:12631515 CiteXplore:12754315 CiteXplore:12770151 CiteXplore:12834252 CiteXplore:12921899 CiteXplore:14622583 CiteXplore:14992292 CiteXplore:15331688 CiteXplore:15388434 CiteXplore:15710237 CiteXplore:15780050 CiteXplore:15911239 CiteXplore:16105183 CiteXplore:16151895 CiteXplore:16214212 CiteXplore:16390611 CiteXplore:16417482 CiteXplore:16444815 CiteXplore:16453318 CiteXplore:16664855 CiteXplore:16686720 CiteXplore:16901953 CiteXplore:16918424 CiteXplore:16986325 CiteXplore:16998855 CiteXplore:17154252 CiteXplore:17383967 CiteXplore:17582620 CiteXplore:17970719 CiteXplore:18079355 CiteXplore:18396796 CiteXplore:18440992 CiteXplore:18593588 CiteXplore:18816054 CiteXplore:18840508 CiteXplore:19028609 CiteXplore:19120667 CiteXplore:19212411 CiteXplore:19259987 CiteXplore:19449910 CiteXplore:19526731 CiteXplore:19544666 CiteXplore:19738917 CiteXplore:19916621 CiteXplore:19924257 CiteXplore:2026685 CiteXplore:21751272 CiteXplore:22044190 CiteXplore:22079563 CiteXplore:22234938 CiteXplore:22264337 CiteXplore:22293292 CiteXplore:22401276 CiteXplore:22411374 CiteXplore:22434786 CiteXplore:24023812 CiteXplore:6198473 CiteXplore:6321058 CiteXplore:6696735 CiteXplore:8456092 CiteXplore:8888048 CiteXplore:9639330 DrugBank:DB00145 ECMDB:ECMDB00123 Gmelin:1808 HMDB:HMDB00123 KEGG COMPOUND:56-40-6 KEGG COMPOUND:C00037 KEGG DRUG:D00011 KNApSAcK:C00001361 MetaCyc:GLY NIST Chemistry WebBook:56-40-6 PDBeChem:GLY Reaxys:635782 Wikipedia:Glycine YMDB:YMDB00016 GLYCINE Glycine aminoacetic acid glycine chebi_ontology 2-Aminoacetate 2-aminoacetic acid 2-aminoethanoic acid Aciport Amino-Acetate Amino-Acetic acid Aminoacetate Aminoacetic acid Aminoessigsaeure Aminoethanoate C2H5NO2 DHMQDGOQFOQNFH-UHFFFAOYSA-N G Glicoamin Gly Glycin Glycocoll Glycolixir Glycosthene Glykokoll Glyzin Gyn-Hydralin H2N-CH2-COOH Hgly InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) Leimzucker NCC(O)=O Padil aminoethanoic acid CHEBI:15428 Glycine glycine CHEBI:15428 CHEBI:15552 CHEBI:10912 CHEBI:245 CHEBI:26331 Beilstein:1690090 CAS:35121-78-9 DrugBank:DB01240 Drug_Central:1034 KEGG:C01312 KEGG:D00106 LIPID_MAPS_instance:LMFA03010087 (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoic acid Prostaglandin I2 chebi_ontology (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate (5Z,9alpha,11alpha,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid 0 352.225 352.46508 C20H32O5 Epoprostenol Flolan InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 KAQKFAOMNZTLHT-OZUDYXHBSA-N PGI2 PGX Prostacyclin Vasocyclin [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)CCCCC)[C@@]1([H])C\C(O2)=C\CCCC(O)=O prostaglandin X CHEBI:15552 prostaglandin I2 CHEBI:15552 CHEBI:15553 A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor. CHEBI:10913 CHEBI:26327 CHEBI:8516 Beilstein:2225571 CAS:551-11-1 Drug_Central:912 HMDB:HMDB01139 KEGG:C00639 KEGG:D00081 LIPID_MAPS_instance:LMFA03010002 MetaCyc:5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY PMID:11438482 PMID:23807981 Reaxys:2225571 Wikipedia:Dinoprost (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid Prostaglandin F2alpha chebi_ontology (+)-Prostaglandin F2a (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate 0 354.241 354.48100 7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid 9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid 9a,11a-PGF2 Amoglandin C20H34O5 CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O Cyclosin Dinoprost Enzaprost Enzaprost F InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 PGF2a PGF2alpha PXGPLTODNUVGFL-YNNPMVKQSA-N Panacelan Prostaglandin F2a Prostin F 2 alpha Protamodin U 14583 dinoprost dinoprosta dinoprostum l-PGF2-alpha l-Prostaglandin F2-alpha CHEBI:15553 prostaglandin F2alpha CHEBI:15553 CHEBI:15555 A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- stereoisomer). CHEBI:10916 CHEBI:246 CHEBI:26321 CHEBI:45044 ChemIDplus:41598-07-6 CiteXplore:11423836 CiteXplore:12148545 CiteXplore:1373750 CiteXplore:15843042 CiteXplore:16289250 CiteXplore:20671299 CiteXplore:24298012 CiteXplore:24447364 CiteXplore:24456221 CiteXplore:2526527 CiteXplore:2723663 CiteXplore:2835791 CiteXplore:3002327 CiteXplore:3139758 CiteXplore:3462506 CiteXplore:3511806 CiteXplore:380688 CiteXplore:3862115 CiteXplore:3890960 CiteXplore:6430299 CiteXplore:6809826 CiteXplore:7712673 CiteXplore:7979442 CiteXplore:806102 CiteXplore:8182221 CiteXplore:8757220 CiteXplore:9836493 DrugBank:DB02056 HMDB:HMDB01403 KEGG COMPOUND:41598-07-6 KEGG COMPOUND:C00696 LIPID MAPS:LMFA03010004 MetaCyc:5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O PDBeChem:PG2 Reaxys:2170623 Wikipedia:Prostaglandin D2 Wikipedia:Prostaglandin_D2 (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic acid Prostaglandin D2 chebi_ontology (5Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3-oxocyclopentyl]hept-5-enoic acid (5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoate (5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoic acid (5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoate (5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid (5Z,13E,15S)-9a,15-dihydroxy-11-oxoprosta-5,13-dien-1-oate (5Z,13E,15S)-9a,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic acid (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate (5Z,9-alpha,13E,15S)-9,15-dihydroxy-11-oxo-Prosta-5,13-dien-1-oate (5Z,9-alpha,13E,15S)-9,15-dihydroxy-11-oxo-Prosta-5,13-dien-1-oic acid (5Z,9alpha,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oate (5Z,9alpha,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid (5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate (5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 11-Dehydroprostaglandin F2-alpha 11-Dehydroprostaglandin F2alpha 9S,15S-Dihydroxy-11-oxo-5Z,13E-prostadienoate 9S,15S-Dihydroxy-11-oxo-5Z,13E-prostadienoic acid BHMBVRSPMRCCGG-OUTUXVNYSA-N C20H32O5 PGD2 CHEBI:15555 PGD2 prostaglandin D2 CHEBI:15555 CHEBI:15558 An optically active form of 15-HETE having 15(S)-configuration.. CHEBI:10824 CHEBI:147 CHEBI:18507 Beilstein:2470466 CAS:54845-95-3 HMDB:HMDB03876 KEGG:C04742 KEGG:D08931 LIPID_MAPS_instance:LMFA03060001 PMID:11212240 PMID:15613483 PMID:15964853 PMID:18494609 PMID:22068350 Reaxys:6125815 (5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid 15(S)-HETE chebi_ontology (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate (15S)-15-hydroxy-5,8,11-cis-13-trans-eicosatetraenoate (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid (15S)-hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid (5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoic acid (5Z,8Z,11Z,13E,15S)-15-hydroxy-5,8,11,13-eicosatetraenoic acid (5Z,8Z,11Z,13E,15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid 0 15(S)-hydroxyeicosatetraenoic acid 15S-HETE 320.235 320.46628 C20H32O3 CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1 JSFATNQSLKRBCI-VAEKSGALSA-N icomucret CHEBI:15558 15(S)-HETE CHEBI:15558 CHEBI:15632 An icosatetraenoic acid in which the double bonds are located at the 6-7, 8-9, 11-12, and 14-15 positions and have E, Z, Z, and Z geometry, respectively, and in which the pro-S hydrogen is substituted by a hydroperoxy group. CHEBI:10924 CHEBI:18601 CHEBI:20573 CHEBI:2061 CHEBI:60942 CAS:71774-08-8 HMDB:HMDB11135 KEGG:C05356 LIPID_MAPS_instance:LMFA03060012 Reaxys:5282501 (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid 5(S)-HPETE chebi_ontology (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate (5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid (S)-5-HPETE 0 336.230 336.46568 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate 5S-HpETE C20H32O4 CCCCC\C=C/C\C=C/C\C=C/C=C/[C@H](CCCC(O)=O)OO InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1 JNUUNUQHXIOFDA-JGKLHWIESA-N CHEBI:15632 5(S)-HPETE CHEBI:15632 CHEBI:15646 The 20-hydroxy derivative of leukotriene B4. CHEBI:10932 CHEBI:1293 CHEBI:19796 HMDB:HMDB01509 KEGG:C04853 LIPID_MAPS_instance:LMFA03020018 PMID:3000366 PMID:8382231 PMID:8609415 (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid 20-Hydroxy-leukotriene B4 chebi_ontology (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoate 0 20-OH-LTB4 20-OH-Leukotriene B4 20-hydroxy-LTB4 352.225 352.46508 C20H32O5 InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1 OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O PTJFJXLGRSTECQ-PSPARDEHSA-N CHEBI:15646 20-hydroxy-leukotriene B4 CHEBI:15646 CHEBI:15647 A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. CHEBI:10933 CHEBI:25024 CHEBI:6421 CAS:71160-24-2 HMDB:HMDB01085 KEGG:C02165 LIPID_MAPS_instance:LMFA03020001 PMID:20400503 PMID:20529300 PMID:6271967 Reaxys:4235309 Wikipedia:Leukotriene_B4 (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid Leukotriene B4 chebi_ontology (5S,12R,6Z,8E,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoic acid (S-(R*,S*-(E,Z,E,Z)))-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid 0 336.230 336.46568 5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid 5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-icosatetraenoic acid 5,12-Dihete 5,12-Hete 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid C20H32O4 CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 LTB4 VNYSSYRCGWBHLG-AMOLWHMGSA-N CHEBI:15647 leukotriene B4 CHEBI:15647 CHEBI:15650 CHEBI:10936 CHEBI:18612 CHEBI:25027 CHEBI:261 CHEBI:6424 CAS:75715-89-8 KEGG:C05952 LIPID_MAPS_instance:LMFA03020002 PMID:19291727 (5S,6R,7E,9E,11Z,14Z)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid Leukotriene E4 S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine chebi_ontology (5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-6-((2-Amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,14-tetraenoate (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate 0 439.239 439.60900 5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid C23H37NO5S CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(O)=O)[C@@H](O)CCCC(O)=O InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 LTE4 OTZRAYGBFWZKMX-FRFVZSDQSA-N CHEBI:15650 leukotriene E4 CHEBI:15650 CHEBI:15713 A pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. CHEBI:13510 CHEBI:27233 CHEBI:9850 Beilstein:71520 ChemIDplus:63-39-8 CiteXplore:10927039 CiteXplore:14719996 CiteXplore:15837087 CiteXplore:6734601 DrugBank:DB04005 Gmelin:307896 HMDB:HMDB00285 KEGG COMPOUND:63-39-8 KEGG COMPOUND:C00075 MetaCyc:UTP PDBeChem:UTP Wikipedia:Uridine triphosphate UTP uridine 5'-(tetrahydrogen triphosphate) chebi_ontology ({[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O [[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid [[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid 5'-UTP C9H15N2O15P3 H4utp PGAVKCOVUIYSFO-XVFCMESISA-N Uridine 5'-triphosphate Uridine mono(tetrahydrogen triphosphate) Uridine triphosphate Uteplex uridine 5'-triphosphoric acid CHEBI:15713 UTP CHEBI:15713 CHEBI:15729 An optically active form of ornithine having L-configuration. CHEBI:13148 CHEBI:21367 CHEBI:6280 Beilstein:1722298 CAS:70-26-8 DrugBank:DB00129 Drug_Central:3401 Gmelin:327282 HMDB:HMDB00214 KEGG:C00077 KEGG:D08302 KNApSAcK:C00001384 MetaCyc:ORNITHINE PDBeChem:ORN PMID:15576628 PMID:17190852 PMID:18676473 PMID:19083482 PMID:19173225 PMID:22033378 PMID:22133808 PMID:22387109 PMID:22735334 Reaxys:1722298 Wikipedia:Ornithine (2S)-2,5-diaminopentanoic acid L-Ornithine L-ornithine chebi_ontology (S)-2,5-Diaminopentanoate (S)-2,5-Diaminopentanoic acid (S)-2,5-diaminovaleric acid (S)-alpha,delta-diaminovaleric acid (S)-ornithine 0 132.090 132.16106 AHLPHDHHMVZTML-BYPYZUCNSA-N C5H12N2O2 InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1 NCCC[C@H](N)C(O)=O CHEBI:15729 L-ornithine CHEBI:15729 CHEBI:15741 An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle. CHEBI:22943 CHEBI:26807 CHEBI:45639 CHEBI:9304 Beilstein:1754069 ChemIDplus:110-15-6 CiteXplore:11067816 CiteXplore:1126459 CiteXplore:11803021 CiteXplore:12097436 CiteXplore:14687733 CiteXplore:15059451 CiteXplore:16143825 CiteXplore:17439666 CiteXplore:18953024 CiteXplore:19212411 CiteXplore:20669995 CiteXplore:21848266 CiteXplore:22932811 CiteXplore:24027187 CiteXplore:3659829 CiteXplore:6882030 CiteXplore:7582870 CiteXplore:7729054 CiteXplore:8013094 CiteXplore:8087979 CiteXplore:8412012 CiteXplore:9693263 DrugBank:DB00139 ECMDB:ECMDB00254 Gmelin:2785 HMDB:HMDB00254 KEGG COMPOUND:110-15-6 KEGG COMPOUND:C00042 KNApSAcK:C00001205 LIPID MAPS:LMFA01170043 MetaCyc:SUC NIST Chemistry WebBook:110-15-6 PDBeChem:SIN Reaxys:1754069 Wikipedia:Succinic acid Wikipedia:Succinic_acid YMDB:YMDB00338 SUCCINIC ACID Succinic acid butanedioic acid succinic acid chebi_ontology InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8) 1,2-Ethanedicarboxylate 1,2-ethanedicarboxylic acid 1,4-Butanedioate 1,4-Butanedioic acid Bernsteinsaeure Butandisaeure Butanedionic acid C4H6O4 Dihydrofumarate Dihydrofumaric acid E363 Ethylenesuccinic acid HOOC-CH2-CH2-COOH KDYFGRWQOYBRFD-UHFFFAOYSA-N Katasuccin OC(=O)CCC(O)=O Succinate Wormwood acid acide butanedioique acide succinique acidum succinicum amber acid asuccin butanedioic acid spirit of amber CHEBI:15741 Succinic acid succinic acid CHEBI:15741 CHEBI:15746 A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism. CHEBI:15098 CHEBI:26734 CHEBI:45583 CHEBI:9219 Beilstein:1750791 CAS:71-44-3 DrugBank:DB00127 Gmelin:454653 HMDB:HMDB01256 KEGG:C00750 KNApSAcK:C00001432 MetaCyc:SPERMINE PDBeChem:SPM PMID:10873205 PMID:10930630 PMID:11341774 PMID:11543598 PMID:11805860 PMID:15145762 PMID:15308338 PMID:15500473 PMID:15972654 PMID:16146631 PMID:16253230 PMID:16664713 PMID:19275753 PMID:19593412 PMID:19962967 PMID:22735334 PMID:23289636 PMID:23418509 PMID:23506248 PMID:23820617 PMID:23887925 PMID:7521253 PMID:7721849 PMID:8524182 PMID:8832899 PMID:9151701 Reaxys:1750791 Wikipedia:Spermine N,N'-bis(3-aminopropyl)butane-1,4-diamine SPERMINE Spermine chebi_ontology 0 202.216 202.34040 4,9-diaza-1,12-dodecanediamine 4,9-diazadodecane-1,12-diamine C10H26N4 InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 N,N'-Bis(3-aminopropyl)-1,4-butanediamine NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N CHEBI:15746 spermine CHEBI:15746 CHEBI:15760 A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine. CHEBI:15276 CHEBI:27174 CHEBI:9799 Beilstein:1099914 CAS:51-67-2 Drug_Central:2784 Gmelin:82946 HMDB:HMDB00306 KEGG:C00483 KNApSAcK:C00001435 LINCS:LSM-19016 MetaCyc:TYRAMINE PDBeChem:AEF PMID:11919655 PMID:12183041 PMID:12811595 PMID:15000446 PMID:15848803 PMID:18422653 PMID:18970430 PMID:19137318 PMID:19189084 PMID:21570963 PMID:21628600 PMID:21651557 PMID:21679153 PMID:21850574 PMID:21909937 PMID:22735334 PMID:3137238 Reaxys:1099914 Wikipedia:Tyramine 4-(2-aminoethyl)phenol Tyramine chebi_ontology 0 137.084 137.17900 2-(p-Hydroxyphenyl)ethylamine 4-Hydroxy-beta-phenylethylamine 4-Hydroxyphenylethylamine 4-hydroxyphenethylamine C8H11NO DZGWFCGJZKJUFP-UHFFFAOYSA-N InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 NCCc1ccc(O)cc1 Tyramin beta-(4-Hydroxyphenyl)ethylamine p-(2-Aminoethyl)phenol p-(2-aminoethyl)phenol p-hydroxyphenethylamine p-hydroxyphenylethylamine p-tyramine CHEBI:15760 tyramine CHEBI:15760 CHEBI:16015 An optically active form of glutamic acid having L-configuration. CHEBI:21304 CHEBI:42825 CHEBI:6224 Beilstein:1723801 ChemIDplus:56-86-0 CiteXplore:10052870 CiteXplore:10736365 CiteXplore:10736373 CiteXplore:11304775 CiteXplore:12073073 CiteXplore:12097436 CiteXplore:12297216 CiteXplore:12869660 CiteXplore:14749132 CiteXplore:14992292 CiteXplore:15135231 CiteXplore:15592994 CiteXplore:15596234 CiteXplore:15739367 CiteXplore:15911239 CiteXplore:15930465 CiteXplore:15939876 CiteXplore:16400059 CiteXplore:16719819 CiteXplore:16892196 CiteXplore:17202478 CiteXplore:18502700 CiteXplore:1851687 CiteXplore:19212411 CiteXplore:19581495 CiteXplore:20300169 CiteXplore:22219301 CiteXplore:22411374 CiteXplore:22735334 CiteXplore:2453224 CiteXplore:3162516 CiteXplore:6696735 CiteXplore:7901400 CiteXplore:8579834 CiteXplore:9004939 CiteXplore:9465528 DrugBank:DB00142 Gmelin:3502 HMDB:HMDB00148 KEGG COMPOUND:56-86-0 KEGG COMPOUND:C00025 KEGG DRUG:D00007 KNApSAcK:C00001358 MetaCyc:GLT NIST Chemistry WebBook:56-86-0 PDBeChem:GLU_LFOH Reaxys:1723801 Wikipedia:E Wikipedia:L-Glutamic_Acid (2S)-2-aminopentanedioic acid L-Glutamic acid L-glutamic acid chebi_ontology InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1 (2S)-2-Aminopentanedioate (2S)-2-Aminopentanedioic acid (S)-(+)-Glutamate (S)-(+)-Glutamic acid (S)-2-Aminopentanedioate (S)-2-aminopentanedioic acid (S)-Glutamate (S)-glutamic acid 1-Amino-propane-1,3-dicarboxylate 1-Amino-propane-1,3-dicarboxylic acid 1-Aminopropane-1,3-dicarboxylate 1-Aminopropane-1,3-dicarboxylic acid 2-Aminoglutarate 2-Aminoglutaric acid 2-Aminopentanedioate 2-Aminopentanedioic acid Aciglut Aminoglutarate Aminoglutaric acid C5H9NO4 E GLUTAMIC ACID Glt Glu Glusate Glut Glutacid Glutamate Glutamicol Glutamidex Glutaminate Glutaminic acid Glutaminol Glutaton L-(+)-Glutamate L-(+)-Glutamic acid L-Glu L-Glutamate L-Glutaminate L-Glutaminic acid L-Glutaminsaeure L-a-Aminoglutarate L-a-Aminoglutaric acid L-alpha-Aminoglutarate L-alpha-Aminoglutaric acid N[C@@H](CCC(O)=O)C(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N a-Aminoglutarate a-Aminoglutaric acid a-Glutamate a-Glutamic acid acide glutamique acido glutamico acidum glutamicum alpha-Aminoglutarate alpha-Aminoglutaric acid alpha-Glutamate alpha-Glutamic acid glutamic acid CHEBI:16015 L-glutamic acid CHEBI:16015 CHEBI:16044 CHEBI:14937 CHEBI:29983 CHEBI:43924 CHEBI:8535 KEGG:C03023 PDBeChem:MET_LL RESID:AA0013 L-methionine residue chebi_ontology -Met- 0 131.040 131.19710 C5H9NOS L-methionine L-methionyl M Met Protein L-methionine CHEBI:16044 L-methionine residue CHEBI:16189 A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid. CHEBI:15135 CHEBI:45687 CHEBI:9335 Beilstein:3648446 ChemIDplus:14808-79-8 CiteXplore:10386253 CiteXplore:10561778 CiteXplore:10783877 CiteXplore:10796145 CiteXplore:10796146 CiteXplore:10917625 CiteXplore:10959410 CiteXplore:11114076 CiteXplore:11200094 CiteXplore:11235060 CiteXplore:11279786 CiteXplore:11452993 CiteXplore:11581495 CiteXplore:11599227 CiteXplore:11798107 CiteXplore:12166931 CiteXplore:12420348 CiteXplore:12440375 CiteXplore:12519550 CiteXplore:12653630 CiteXplore:12653631 CiteXplore:12653633 CiteXplore:12653636 CiteXplore:12668033 CiteXplore:12735485 CiteXplore:12804383 CiteXplore:12878436 CiteXplore:12915942 CiteXplore:13679662 CiteXplore:14583910 CiteXplore:14583911 CiteXplore:14597181 CiteXplore:14609305 CiteXplore:14690476 CiteXplore:1472758 CiteXplore:15093386 CiteXplore:15152354 CiteXplore:1516727 CiteXplore:15613519 CiteXplore:15715602 CiteXplore:15749066 CiteXplore:15984785 CiteXplore:16026302 CiteXplore:16072037 CiteXplore:16186560 CiteXplore:16345535 CiteXplore:16347366 CiteXplore:16348007 CiteXplore:16406662 CiteXplore:16475944 CiteXplore:16483812 CiteXplore:16534979 CiteXplore:16656509 CiteXplore:16709175 CiteXplore:16709181 CiteXplore:16709182 CiteXplore:16709184 CiteXplore:16709185 CiteXplore:16709187 CiteXplore:16709188 CiteXplore:16742508 CiteXplore:16742518 CiteXplore:16917509 CiteXplore:17120760 CiteXplore:17168807 CiteXplore:17420092 CiteXplore:17439666 CiteXplore:17460664 CiteXplore:17515291 CiteXplore:17636771 CiteXplore:17692016 CiteXplore:17709180 CiteXplore:17714467 CiteXplore:18398178 CiteXplore:18815700 CiteXplore:18846414 CiteXplore:19047345 CiteXplore:19244483 CiteXplore:1939488 CiteXplore:19544990 CiteXplore:19628332 CiteXplore:19812358 CiteXplore:2094230 CiteXplore:24246267 CiteXplore:7823020 CiteXplore:7829123 CiteXplore:8038262 CiteXplore:8201096 CiteXplore:8805242 CiteXplore:8878010 CiteXplore:8943798 CiteXplore:9172804 CiteXplore:9251237 CiteXplore:9422978 CiteXplore:9449976 CiteXplore:9573551 Gmelin:2120 HMDB:HMDB01448 KEGG COMPOUND:C00059 KEGG DRUG:D05963 MetaCyc:NH42SO4 MetaCyc:SULFATE NIST Chemistry WebBook:14808-79-8 PDBeChem:SO4 Reaxys:3648446 Wikipedia:Sulfate Sulfate sulfate tetraoxidosulfate(2-) tetraoxosulfate(2-) tetraoxosulfate(VI) chebi_ontology InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 O4S QAOWNCQODCNURD-UHFFFAOYSA-L SO4(2-) SULFATE ION Sulfate (ion 2-) Sulfate anion Sulfate anion(2-) Sulfate dianion Sulfate ion Sulfate ion (SO42-) Sulfate(2-) Sulfuric acid ion(2-) [O-]S([O-])(=O)=O [SO4](2-) sulphate sulphate ion CHEBI:16189 Sulfate sulfate CHEBI:16189 CHEBI:16325 A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action. CHEBI:1711 CHEBI:20238 CHEBI:20239 Beilstein:3217757 CAS:434-13-9 HMDB:HMDB00761 KEGG:C03990 LINCS:LSM-5371 LIPID_MAPS_instance:LMST04010003 MetaCyc:CPD-7235 PDBeChem:4OA PMID:23639599 PMID:24270587 PMID:24332653 PMID:24399466 PMID:7068113 Reaxys:3217757 Wikipedia:Lithocholic_acid 3alpha-hydroxy-5beta-cholan-24-oic acid Lithocholic acid chebi_ontology (3alpha,5beta)-3-hydroxycholan-24-oic acid 0 376.298 376.57260 3alpha-Hydroxy-5beta-cholanate 3alpha-Hydroxy-5beta-cholanic acid 3alpha-hydroxy-5beta-cholanic acid 3alpha-hydroxy-5beta-cholanoic acid 5beta-cholanic acid-3alpha-ol C24H40O3 InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1 SMEROWZSTRWXGI-HVATVPOCSA-N [H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])(CC[C@@]34[H])[C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@H](O)C2 CHEBI:16325 lithocholic acid CHEBI:16325 CHEBI:16335 A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond. CHEBI:13734 CHEBI:22237 CHEBI:2472 CHEBI:40558 CHEBI:40825 CHEBI:40906 Beilstein:93029 ChemIDplus:58-61-7 CiteXplore:11213237 CiteXplore:11820865 CiteXplore:11978011 CiteXplore:12927681 CiteXplore:15028034 CiteXplore:15116424 CiteXplore:15455468 CiteXplore:15882454 CiteXplore:16177183 CiteXplore:16177794 CiteXplore:16178799 CiteXplore:16181820 CiteXplore:16181825 CiteXplore:16183671 CiteXplore:16917093 CiteXplore:17190852 CiteXplore:18000974 CiteXplore:19309105 CiteXplore:21330412 CiteXplore:21848266 CiteXplore:23857558 CiteXplore:323854 CiteXplore:6656991 CiteXplore:7056808 CiteXplore:7686877 CiteXplore:9869364 DrugBank:DB00640 ECMDB:ECMDB00050 Gmelin:53385 HMDB:HMDB00050 KEGG COMPOUND:58-61-7 KEGG COMPOUND:C00212 KEGG DRUG:D00045 KNApSAcK:C00007444 MetaCyc:ADENOSINE NIST Chemistry WebBook:58-61-7 PDBeChem:ADN Reaxys:93029 Wikipedia:Adenosine YMDB:YMDB00058 ADENOSINE Adenosine adenosine chebi_ontology (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-methylol-tetrahydrofuran-3,4-diol (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose 1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 6-Amino-9-beta-D-ribofuranosyl-9H-purine 6-Amino-9beta-D-ribofuranosyl-9H-purine 6-Amino-9beta-delta-ribofuranosyl-9H-purine 9-beta-D-Arabinofuranosyladenine 9-beta-D-Ribofuranosidoadenine 9-beta-D-Ribofuranosyl-9H-purin-6-amine 9-beta-D-Ribofuranosyladenine 9-beta-D-ribofuranosyl-9H-purin-6-amine 9-beta-delta-Arabinofuranosyladenine 9-beta-delta-Ribofuranosidoadenine 9-beta-delta-Ribofuranosyl-9H-purin-6-amine 9-beta-delta-Ribofuranosyladenine 9beta-D-Ribofuranosyladenine 9beta-D-ribofuranosyl-9H-Purin-6-amine 9beta-delta-Ribofuranosyladenine 9beta-delta-ribofuranosyl-9H-Purin-6-amine Ade-Rib Adenine Deoxyribonucleoside Adenine nucleoside Adenine riboside Adenine-9beta-D-Ribofuranoside Adenine-9beta-delta-Ribofuranoside Adenocard Adenocor Adenoscan Adenosin Adenyldeoxyriboside Ado Boniton C10H13N5O4 Deoxyadenosine Desoxyadenosine Myocol Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O Nucleocardyl OIRDTQYFTABQOQ-KQYNXXCUSA-N Sandesin b-D-Adenosine beta-Adenosine beta-D-Adenosine beta-delta-Adenosine CHEBI:16335 Adenosine adenosine CHEBI:16335 CHEBI:16349 The L-enantiomer of citrulline. CHEBI:13092 CHEBI:21257 CHEBI:41489 CHEBI:6203 Beilstein:1725416 Beilstein:6055157 CAS:372-75-8 DrugBank:DB00155 Drug_Central:3103 ECMDB:ECMDB00904 Gmelin:774677 HMDB:HMDB00904 KEGG:C00327 KEGG:D07706 KNApSAcK:C00001348 MetaCyc:L-CITRULLINE PDBeChem:CIR PMID:11862757 PMID:17190852 PMID:18022291 PMID:19173225 PMID:21067832 PMID:21915076 PMID:21955999 PMID:22119809 PMID:22345866 PMID:22348173 PMID:22387109 PMID:22388927 PMID:22402328 PMID:22402472 PMID:22512552 Reaxys:1725416 Wikipedia:Citrulline YMDB:YMDB00060 (2S)-2-amino-5-(carbamoylamino)pentanoic acid L-Citrulline L-citrulline N(5)-carbamoyl-L-ornithine chebi_ontology (S)-2-Amino-5-ureidopentanoic acid 0 175.096 175.18584 2-Amino-5-ureidovaleric acid C6H13N3O3 CITRULLINE Cit Citrulline InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 L-2-Amino-5-ureidovaleric acid N(5)-(aminocarbonyl)-L-ornithine N(delta)-carbamylornithine N5-(Aminocarbonyl)ornithine N5-carbamoylornithine N[C@@H](CCCNC(N)=O)C(O)=O RHGKLRLOHDJJDR-BYPYZUCNSA-N alpha-amino-delta-ureidovaleric acid delta-ureidonorvaline CHEBI:16349 L-citrulline CHEBI:16349 CHEBI:16359 A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12. CHEBI:1694 CHEBI:20223 CHEBI:23210 CHEBI:41494 Beilstein:2822009 CAS:81-25-4 DrugBank:DB02659 Drug_Central:3096 HMDB:HMDB00619 KEGG:C00695 LINCS:LSM-5541 LIPID_MAPS_instance:LMST04010001 MetaCyc:CHOLATE PDBeChem:CHD PMID:22770225 Reaxys:2822009 Wikipedia:Cholic_Acid 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid CHOLIC ACID Cholic acid chebi_ontology (3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxycholan-24-oic acid 0 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanic acid 408.288 408.57140 BHQCQFFYRZLCQQ-OELDTZBJSA-N C24H40O5 Cholsaeure InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1 [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])C[C@H](O)[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@H](O)C2)[C@H](C)CCC(O)=O CHEBI:16359 cholic acid CHEBI:16359 CHEBI:16467 An L-alpha-amino acid that is the L-isomer of arginine. CHEBI:13077 CHEBI:21235 CHEBI:42927 CHEBI:6185 Beilstein:1725413 CAS:74-79-3 DrugBank:DB00125 Drug_Central:1549 ECMDB:ECMDB00517 Gmelin:83283 HMDB:HMDB00517 KEGG:C00062 KEGG:D02982 KNApSAcK:C00001340 MetaCyc:ARG PDBeChem:ARG PDBeChem:GND PMID:10848923 PMID:11139824 PMID:11300497 PMID:11898853 PMID:12812828 PMID:15016745 PMID:15465805 PMID:16056256 PMID:16416365 PMID:17168727 PMID:17439666 PMID:19030957 PMID:21600268 PMID:21814794 PMID:22179117 PMID:22243793 PMID:22251130 PMID:22361732 PMID:22425811 PMID:22428068 PMID:22439203 PMID:22553931 PMID:22619480 PMID:22626826 PMID:22652429 PMID:22667467 PMID:22709481 PMID:8070089 Reaxys:1725413 Wikipedia:L-arginine YMDB:YMDB00592 L-Arginine L-arginine chebi_ontology (2S)-2-amino-5-(carbamimidamido)pentanoic acid (2S)-2-amino-5-guanidinopentanoic acid (S)-2-Amino-5-guanidinovaleric acid (S)-2-amino-5-guanidinopentanoic acid 0 174.112 174.20100 Arg C6H14N4O2 InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1 L-(+)-arginine L-Arg L-Arginin N[C@@H](CCCNC(N)=N)C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-N R arginine CHEBI:16467 L-arginine CHEBI:16467 CHEBI:16670 Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc. Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc. CHEBI:14753 CHEBI:25906 CHEBI:7990 KEGG COMPOUND:C00012 KEGG:C00012 Peptide peptides chebi_ontology (C2H2NOR)nC2H3NOR 0 Peptid peptido peptidos CHEBI:16670 Peptide peptide CHEBI:16670 CHEBI:16755 A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively. CHEBI:23094 CHEBI:3588 CHEBI:3593 Beilstein:3219887 ChemIDplus:474-25-9 CiteXplore:10542066 CiteXplore:10597755 CiteXplore:10656538 CiteXplore:10766400 CiteXplore:10781781 CiteXplore:10889168 CiteXplore:11248487 CiteXplore:11316487 CiteXplore:11530998 CiteXplore:11907135 CiteXplore:11957790 CiteXplore:12576301 CiteXplore:12632357 CiteXplore:12846445 CiteXplore:14582467 CiteXplore:15040040 CiteXplore:15185309 CiteXplore:16037564 CiteXplore:16548228 CiteXplore:22664055 CiteXplore:24448653 CiteXplore:24464484 CiteXplore:2621422 CiteXplore:7601437 CiteXplore:8618139 CiteXplore:8742915 CiteXplore:9051880 CiteXplore:9425933 CiteXplore:9664985 DrugBank:DB06777 HMDB:HMDB00518 KEGG COMPOUND:474-25-9 KEGG COMPOUND:C02528 KEGG DRUG:D00163 LIPID MAPS:LMST04010032 PDBeChem:JN3 Reaxys:3219887 Wikipedia:Chenodeoxycholic acid Wikipedia:Chenodiol 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid Chenodeoxycholic acid chebi_ontology (4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7-bis(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@H](O)C2)[C@H](C)CCC(O)=O (+)-chenodeoxycholate (+)-chenodeoxycholic acid (3a,5b,7a)-3,7-dihydroxy-cholan-24-oate (3a,5b,7a)-3,7-dihydroxy-cholan-24-oic acid 3a,7a-Dihydroxy-5b,14a,17b-cholanate 3a,7a-Dihydroxy-5b,14a,17b-cholanic acid 3a,7a-Dihydroxy-5b-cholan-24-oate 3a,7a-Dihydroxy-5b-cholan-24-oic acid 3a,7a-Dihydroxy-5b-cholanate 3a,7a-Dihydroxy-5b-cholanic acid 3alpha,7alpha-Dihydroxy-5beta-cholanic acid 7a-Hydroxy-desoxycholsaeure 7alpha-hydroxylithocholic acid C24H40O4 CDCA Chenix Chenodeoxycholate Chenodesoxycholsaeure Chenodiol RUDATBOHQWOJDD-BSWAIDMHSA-N anthropodeoxycholic acid anthropodesoxycholic acid chenic acid gallodesoxycholic acid CHEBI:16755 Chenodeoxycholic acid chenodeoxycholic acid CHEBI:16755 CHEBI:16761 A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase. CHEBI:13222 CHEBI:22244 CHEBI:2342 CHEBI:40553 Beilstein:67722 COMe:MOL000173 ChemIDplus:58-64-0 CiteXplore:1399831 CiteXplore:1515641 CiteXplore:15654516 CiteXplore:15763887 CiteXplore:15869601 CiteXplore:15882454 CiteXplore:15886810 CiteXplore:15945611 CiteXplore:15993662 CiteXplore:16295522 CiteXplore:16307036 CiteXplore:16371119 CiteXplore:16761747 CiteXplore:17010792 CiteXplore:24023812 CiteXplore:8719843 DrugBank:DB03431 Gmelin:88452 HMDB:HMDB01341 KEGG COMPOUND:20398-34-9 KEGG COMPOUND:58-64-0 KEGG COMPOUND:C00008 KEGG GLYCAN:G11113 KNApSAcK:C00019353 MetaCyc:ADP PDBeChem:ADP Reaxys:67722 Wikipedia:ADP ADP adenosine 5'-(trihydrogen diphosphate) chebi_ontology InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid 5'-adenylphosphoric acid ADENOSINE-5'-DIPHOSPHATE Adenosindiphosphorsaeure Adenosine 5'-diphosphate Adenosine 5'-pyrophosphate Adenosine diphosphate Adenosine pyrophosphate Adenosine-5'-diphosphate Adenosine-5-diphosphate Adenosine-diphosphate C10H15N5O10P2 H3adp XTWYTFMLZFPYCI-KQYNXXCUSA-N adenosine 5'-(trihydrogen diphosphate) CHEBI:16761 ADP CHEBI:16761 CHEBI:16765 An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position. CHEBI:15274 CHEBI:27161 CHEBI:46157 CHEBI:9767 Beilstein:125513 CAS:61-54-1 DrugBank:DB08653 Gmelin:603448 HMDB:HMDB00303 KEGG:C00398 KNApSAcK:C00001434 MetaCyc:TRYPTAMINE PDBeChem:TSS PMID:16126914 PMID:22770225 PMID:24345948 PMID:24558969 Reaxys:125513 Wikipedia:Tryptamine 2-(1H-indol-3-yl)ethanamine Tryptamine chebi_ontology 0 160.100 160.21570 1H-indole-3-ethanamine 2-(1H-INDOL-3-YL)ETHANAMINE 2-(3-indolyl)ethylamine 3-(2-Aminoethyl)indole APJYDQYYACXCRM-UHFFFAOYSA-N C10H12N2 InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2 NCCc1c[nH]c2ccccc12 CHEBI:16765 tryptamine CHEBI:16765 CHEBI:16796 A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans. CHEBI:14577 CHEBI:25180 CHEBI:6730 Beilstein:205542 ChemIDplus:73-31-4 CiteXplore:10960829 CiteXplore:11339508 CiteXplore:11462772 CiteXplore:11510949 CiteXplore:11721091 CiteXplore:12142740 CiteXplore:12395907 CiteXplore:12767050 CiteXplore:12853293 CiteXplore:14767300 CiteXplore:15206778 CiteXplore:15681810 CiteXplore:15683468 CiteXplore:15992934 CiteXplore:16030176 CiteXplore:16150115 CiteXplore:16207290 CiteXplore:16217125 CiteXplore:16217126 CiteXplore:16258371 CiteXplore:16441547 CiteXplore:16441550 CiteXplore:16573644 CiteXplore:16678784 CiteXplore:18187545 CiteXplore:18212404 CiteXplore:18485664 CiteXplore:288858 CiteXplore:7773197 CiteXplore:9449169 DrugBank:DB01065 HMDB:HMDB01389 KEGG COMPOUND:73-31-4 KEGG COMPOUND:C01598 KEGG DRUG:D08170 MetaCyc:N-ACETYL-5-METHOXY-TRYPTAMINE NIST Chemistry WebBook:73-31-4 PDBeChem:ML1 Reaxys:205542 Wikipedia:Melatonin Melatonin N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide melatonin chebi_ontology InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) 5-methoxy-N-acetyltryptamine C13H16N2O2 COc1ccc2[nH]cc(CCNC(C)=O)c2c1 Circadin DRLFMBDRBRZALE-UHFFFAOYSA-N MT6 Melatol Melatonin (synth.) standard-grade Melatonin (synth.) ultra-pure Melovine N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide N-Acetyl-5-methoxy-tryptamine N-Acetyl-5-methoxy-tryptamine Melatonine N-Acetyl-5-methoxytryptamine N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide N-[2-(5-methoxyindol-3-yl)ethyl]acetamide Regulin melatonine {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide {N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide CHEBI:16796 Melatonin melatonin CHEBI:16796 CHEBI:16828 The L-enantiomer of tryptophan. CHEBI:13178 CHEBI:184633 CHEBI:21407 CHEBI:45988 CHEBI:46086 CHEBI:46125 CHEBI:46225 CHEBI:6310 Beilstein:86197 CAS:73-22-3 DrugBank:DB00150 Drug_Central:2780 ECMDB:ECMDB00929 Gmelin:51434 HMDB:HMDB00929 KEGG:C00078 KEGG:D00020 KNApSAcK:C00001396 MetaCyc:TRP PDBeChem:TRP PMID:11395471 PMID:11750787 PMID:11888576 PMID:12766158 PMID:12830226 PMID:12871129 PMID:15206750 PMID:16740930 PMID:16934873 PMID:17127472 PMID:17177562 PMID:17430113 PMID:17585690 PMID:17690425 PMID:17826001 PMID:18234569 PMID:18419734 PMID:18949702 PMID:19896323 PMID:21856896 PMID:22071091 PMID:22162421 PMID:22299628 PMID:22386992 PMID:22402312 PMID:22415302 PMID:22415306 PMID:2917974 Reaxys:86197 Wikipedia:Tryptophan YMDB:YMDB00126 L-Tryptophan L-tryptophan chebi_ontology (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid (S)-alpha-Amino-beta-(3-indolyl)-propionic acid (S)-alpha-amino-1H-indole-3-propanoic acid (S)-tryptophan 0 204.090 204.22526 C11H12N2O2 InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 L-(-)-tryptophan L-beta-3-indolylalanine N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O QIVBCDIJIAJPQS-VIFPVBQESA-N TRYPTOPHAN Trp Tryptophan W tryptophan CHEBI:16828 L-tryptophan CHEBI:16828 A sphingoid 1-phosphate that is the monophosphorylated derivative of sphinganine. CHEBI:15100 CHEBI:23767 CHEBI:9222 Beilstein:6780476 ChemIDplus:19794-97-9 CiteXplore:20671299 HMDB:HMDB01383 KEGG COMPOUND:19794-97-9 KEGG COMPOUND:C01120 KNApSAcK:C00007541 LIPID MAPS:LMSP01050002 MetaCyc:CPD-649 Reaxys:6780476 Sphinganine 1-phosphate sphinganine 1-(dihydrogen phosphate) chebi_ontology (2S,3R)-2-amino-3-hydroxyoctadecyl dihydrogen phosphate InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1 {[(2S,3R)-2-amino-3-hydroxyoctadecyl]oxy}phosphonic acid 2-Amino-3-hydroxyoctadecyl dihydrogen phosphate C18H40NO5P CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)COP(O)(O)=O Dihydrosphingosine 1-phosphate YHEDRJPUIRMZMP-ZWKOTPCHSA-N dihydrosphingosine-1-phosphate CHEBI:16893 Dihydrosphingosine-1-phosphate sphinganine 1-phosphate CHEBI:16893 CHEBI:16977 The L-enantiomer of alanine. CHEBI:13069 CHEBI:21216 CHEBI:40734 CHEBI:40735 CHEBI:46308 CHEBI:6171 Beilstein:1720248 CAS:56-41-7 DrugBank:DB00160 Drug_Central:4255 ECMDB:ECMDB00161 Gmelin:49628 HMDB:HMDB00161 KEGG:C00041 KEGG:D00012 KNApSAcK:C00001332 MetaCyc:ALPHA-ALANINE PDBeChem:ALA_LFOH PMID:18235971 PMID:22735334 PMID:3275662 Reaxys:1720248 Wikipedia:Alanine YMDB:YMDB00154 L-Alanine L-alanine chebi_ontology (2S)-2-aminopropanoic acid (S)-2-aminopropanoic acid (S)-alanine 0 89.048 89.09322 A ALANINE Ala C3H7NO2 C[C@H](N)C(O)=O InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 L-2-Aminopropionic acid L-Alanin L-alpha-Alanine L-alpha-alanine QNAYBMKLOCPYGJ-REOHCLBHSA-N CHEBI:16977 L-alanine CHEBI:16977 CHEBI:16978 A leukotriene that contains cysteine in their structure. CHEBI:14504 CHEBI:25025 CHEBI:6422 ChemIDplus:72025-60-6 CiteXplore:10064732 CiteXplore:12895596 CiteXplore:15243994 CiteXplore:15537867 CiteXplore:1652771 CiteXplore:2007712 CiteXplore:20671299 CiteXplore:2411760 CiteXplore:24244016 CiteXplore:2509375 CiteXplore:2512259 CiteXplore:2558123 CiteXplore:2633615 CiteXplore:3153930 CiteXplore:3418380 CiteXplore:3421265 CiteXplore:6440558 CiteXplore:7714683 CiteXplore:8415814 CiteXplore:8434868 CiteXplore:8608646 CiteXplore:8938552 CiteXplore:8939179 CiteXplore:9042024 CiteXplore:9051719 CiteXplore:9384524 CiteXplore:9642160 HMDB:HMDB01198 KEGG COMPOUND:72025-60-6 KEGG COMPOUND:C02166 LIPID MAPS:LMFA03020003 MetaCyc:LEUKOTRIENE-C4 Reaxys:4732117 Wikipedia:Leukotriene C4 Wikipedia:Leukotriene_C4 L-gamma-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl]-L-cysteinylglycine Leukotriene C4 chebi_ontology (5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-[(4S)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)glycine (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine 5S-Hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoate 5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 L-gamma-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinyl-glycine [R-[R*,S*-(E,E,Z,Z)]]-N-[S-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-N-L-gamma-glutamyl-L-cysteinyl]-Glycine 5S,6R-LTC4 5S,6R-Ltc 5S,6R-Ltc(sub 4) C30H47N3O9S GWNVDXQDILPJIG-NXOLIXFESA-N LTC LTC (sub 4) LTC4 Leucotriene C4 Leukotriene C Leukotriene C1 CHEBI:16978 LTC4 leukotriene C4 CHEBI:16978 CHEBI:17115 The L-enantiomer of serine. CHEBI:13167 CHEBI:21387 CHEBI:45440 CHEBI:45451 CHEBI:45590 CHEBI:45597 CHEBI:45677 CHEBI:6301 Beilstein:1721404 CAS:56-45-1 DrugBank:DB00133 Drug_Central:4127 ECMDB:ECMDB00187 Gmelin:2570 HMDB:HMDB00187 KEGG:C00065 KEGG:D00016 KNApSAcK:C00001393 MetaCyc:SER PDBeChem:SER PMID:1650428 PMID:17439666 PMID:19062365 PMID:21956576 PMID:22265470 PMID:22393170 PMID:22547037 PMID:22566084 PMID:22566694 Reaxys:1721404 Wikipedia:L-serine YMDB:YMDB00112 L-Serine L-serine chebi_ontology (2S)-2-amino-3-hydroxypropanoic acid (S)-(-)-serine (S)-2-amino-3-hydroxypropanoic acid (S)-alpha-Amino-beta-hydroxypropionic acid (S)-serine 0 105.043 105.09262 C3H7NO3 InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 L-(-)-serine L-2-Amino-3-hydroxypropionic acid L-3-Hydroxy-2-aminopropionic acid L-3-Hydroxy-alanine L-Ser L-Serin MTCFGRXMJLQNBG-REOHCLBHSA-N N[C@@H](CO)C(O)=O S SERINE Ser Serine beta-Hydroxy-L-alanine beta-Hydroxyalanine CHEBI:17115 L-serine CHEBI:17115 CHEBI:17351 An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry. CHEBI:25047 CHEBI:42395 CHEBI:6479 Beilstein:1727101 CAS:60-33-3 Drug_Central:3323 Gmelin:57557 HMDB:HMDB00673 KEGG:C01595 KNApSAcK:C00001224 LIPID_MAPS_instance:LMFA01030120 MetaCyc:LINOLEIC_ACID PDBeChem:EIC PMID:11113630 PMID:11304127 PMID:11322990 PMID:14667063 PMID:14993245 PMID:15115315 PMID:15642793 PMID:15969511 PMID:16254037 PMID:16563718 PMID:17647039 PMID:18044828 PMID:18990554 PMID:19628674 PMID:19936816 PMID:23900039 PMID:24081493 PMID:6205897 Reaxys:1727101 Wikipedia:Linoleic_acid (9Z,12Z)-octadeca-9,12-dienoic acid LINOLEIC ACID Linoleic acid chebi_ontology (9Z,12Z)-Octadecadienoic acid (Z,Z)-9,12-octadecadienoic acid 0 280.240 280.44550 9-cis,12-cis-Octadecadienoic acid 9Z,12Z-octadecadienoic acid C18:2 9c, 12c omega6 todos cis-9,12-octadienoico C18:2, n-6,9 all-cis C18H32O2 CCCCC\C=C/C\C=C/CCCCCCCC(O)=O InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9- LA OYHQOLUKZRVURQ-HZJYTTRNSA-N acide cis-linoleique acide linoleique acido linoleico all-cis-9,12-octadecadienoic acid cis,cis-9,12-octadecadienoic acid cis,cis-linoleic acid cis-Delta(9,12)-octadecadienoic acid linolic acid CHEBI:17351 linoleic acid CHEBI:17351 The carbon oxoanion resulting from the removal of a proton from carbonic acid. CHEBI:13363 CHEBI:22863 CHEBI:40961 CHEBI:5589 Beilstein:3903504 ChemIDplus:71-52-3 CiteXplore:17215880 CiteXplore:17505962 CiteXplore:4208463 Gmelin:49249 HMDB:HMDB00595 KEGG COMPOUND:C00288 MetaCyc:HCO3 PDBeChem:BCT Wikipedia:Bicarbonate Hydrogencarbonate hydrogen(trioxidocarbonate)(1-) hydrogencarbonate hydrogencarbonate(1-) hydrogentrioxocarbonate(1-) hydrogentrioxocarbonate(IV) hydroxidodioxidocarbonate(1-) chebi_ontology Acid carbonate BICARBONATE ION BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Bicarbonate (HCO3-) Bicarbonate anion Bicarbonate ion Bicarbonate ion (HCO31-) Bicarbonate ions CHO3 Carbonate Carbonate (HCO31-) Carbonate ion (HCO31-) Carbonic acid HCO3(-) HCO3- Hydrocarbonate(1-) Hydrogen carbonate (HCO3-) Hydrogen carbonate anion Hydrogen carbonate ion Hydrogen carbonate ion (HCO3-) Hydrogentrioxocarbonate InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 Monohydrogen carbonate OC([O-])=O [CO2(OH)](-) bicarbonate hydrogen carbonate CHEBI:17544 Hydrogencarbonate hydrogencarbonate CHEBI:17544 CHEBI:17659 A pyrimidine ribonucleoside 5'-diphosphate that has formula C9H14N2O12P2. CHEBI:13445 CHEBI:27230 CHEBI:46402 CHEBI:9802 Beilstein:64707 ChemIDplus:58-98-0 CiteXplore:11023036 CiteXplore:12351530 CiteXplore:1257952 CiteXplore:14558596 CiteXplore:15170365 CiteXplore:19212411 CiteXplore:9460170 DrugBank:DB03435 HMDB:HMDB00295 KEGG COMPOUND:58-98-0 KEGG COMPOUND:C00015 KEGG GLYCAN:G10619 KNApSAcK:C00007313 MetaCyc:UDP PDBeChem:UDP Wikipedia:UDP Wikipedia:Uridine_Diphosphate UDP uridine 5'-(trihydrogen diphosphate) chebi_ontology InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O [({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid [[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid [[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid 5'-UDP C9H14N2O12P2 URIDINE-5'-DIPHOSPHATE Uridine 5'-diphosphate Uridine 5'-pyrophosphate Uridine 5'-pyrophosphorate Uridine 5'-pyrophosphoric acid Uridine diphosphate Uridine pyrophosphate XCCTYIAWTASOJW-XVFCMESISA-N uridine 5'-(trihydrogen diphosphate) CHEBI:17659 UDP CHEBI:17659 CHEBI:17996 A halide anion formed when chlorine picks up an electron to form an an anion. CHEBI:13291 CHEBI:13970 CHEBI:3616 CHEBI:3731 CHEBI:48804 Beilstein:3587171 ChemIDplus:16887-00-6 CiteXplore:15300163 CiteXplore:16078037 CiteXplore:17539703 CiteXplore:17562499 CiteXplore:17729441 CiteXplore:24246267 CiteXplore:7539703 Gmelin:14910 HMDB:HMDB00492 KEGG COMPOUND:16887-00-6 KEGG COMPOUND:C00115 KEGG COMPOUND:C00698 MetaCyc:CPD-4521 NIST Chemistry WebBook:16887-00-6 PDBeChem:CL UM-BBD:c0884 Wikipedia:Chlorine Chloride chloride chloride(1-) chebi_ontology Bertholite CHLORIDE ION Chloor Chlor Chlore Chloride ion Chloride(1-) Chlorine anion Chlorine gas Cl Cl(-) Cl- Cl2 Diatomic chlorine Dichlorine InChI=1S/ClH/h1H/p-1 Molecular chlorine VEXZGXHMUGYJMC-UHFFFAOYSA-M [Cl-] CHEBI:17996 Chloride chloride CHEBI:17996 CHEBI:18019 An L-alpha-amino acid; the L-isomer of lysine. CHEBI:13135 CHEBI:21351 CHEBI:43950 CHEBI:6264 Beilstein:1722531 CAS:56-87-1 DrugBank:DB00123 Drug_Central:1622 ECMDB:ECMDB00182 Gmelin:364182 HMDB:HMDB00182 KEGG:C00047 KEGG:D02304 KNApSAcK:C00001378 MetaCyc:LYS PMID:10930630 PMID:16901854 PMID:17051348 PMID:17979222 PMID:22019452 PMID:22064742 PMID:22575419 PMID:22735334 PMID:23167968 PMID:23325920 PMID:23722415 PMID:24064214 PMID:24831709 PMID:25108762 PMID:8070089 PMID:8587651 Reaxys:1722531 Wikipedia:Lysine YMDB:YMDB00330 (2S)-2,6-diaminohexanoic acid L-Lysine L-lysine chebi_ontology (S)-2,6-diaminohexanoic acid (S)-alpha,epsilon-diaminocaproic acid (S)-lysine 0 146.106 146.18764 6-ammonio-L-norleucine C6H14N2O2 InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1 K KDXKERNSBIXSRK-YFKPBYRVSA-N L-2,6-Diaminocaproic acid L-Lysin Lys Lysine acid NCCCC[C@H](N)C(O)=O lysina lysine lysinum CHEBI:18019 L-lysine CHEBI:18019 CHEBI:18050 An optically active form of glutamine having L-configuration. CHEBI:13110 CHEBI:21308 CHEBI:42812 CHEBI:42814 CHEBI:42899 CHEBI:42943 CHEBI:6227 Beilstein:1723797 CAS:56-85-9 DrugBank:DB00130 Drug_Central:1311 ECMDB:ECMDB00641 Gmelin:3509 HMDB:HMDB00641 KEGG:C00064 KEGG:D00015 KNApSAcK:C00001359 LINCS:LSM-4741 MetaCyc:GLN PDBeChem:GLN PMID:11139387 PMID:15204730 PMID:22055478 PMID:22206385 PMID:22451274 PMID:22453904 PMID:22575040 PMID:22770225 Reaxys:1723797 Wikipedia:Glutamine YMDB:YMDB00002 L-Glutamine L-glutamine chebi_ontology (2S)-2,5-diamino-5-oxopentanoic acid (2S)-2-amino-4-carbamoylbutanoic acid (S)-2,5-diamino-5-oxopentanoic acid 0 146.069 146.14458 C5H10N2O3 GLUTAMINE Glutamic acid 5-amide Glutamic acid amide InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 L-(+)-glutamine L-2-Aminoglutaramic acid L-2-aminoglutaramic acid L-Glutamin L-Glutaminsaeure-5-amid L-glutamic acid gamma-amide Levoglutamide N[C@@H](CCC(N)=O)C(O)=O Q ZDXPYRJPNDTMRX-VKHMYHEASA-N CHEBI:18050 L-glutamine CHEBI:18050 CHEBI:18059 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids. 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids. CHEBI:14517 CHEBI:25054 CHEBI:6486 KEGG COMPOUND:C01356 KEGG:C01356 Lipid lipid lipids chebi_ontology . CHEBI:18059 Lipid lipid CHEBI:18059 CHEBI:18066 A UDP-sugar having D-glucose as the sugar component. CHEBI:13498 CHEBI:13505 CHEBI:22103 CHEBI:27234 CHEBI:9845 CHEBI:9895 CAS:133-89-1 KEGG:C00029 UDP-D-glucose uridine 5'-[3-D-glucopyranosyl dihydrogen diphosphate] chebi_ontology 0 566.055 566.30186 C15H24N2O17P2 HSCJRCZFDFQWRP-RDKQLNKOSA-N InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 OC[C@H]1OC(OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O UDP-Glc UDP-glucose UDPglucose Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-glucopyranosyl ester Uridine 5'-(trihydrogen diphosphate), mono-alpha-d-glucopyranosyl ester Uridine diphosphate glucose uridinediphosphoglucose CHEBI:18066 UDP-D-glucose CHEBI:18066 CHEBI:18243 Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group. CHEBI:11695 CHEBI:11930 CHEBI:14203 CHEBI:1764 CHEBI:23886 CHEBI:43686 ChemIDplus:51-61-6 CiteXplore:10489384 CiteXplore:10494443 CiteXplore:10629745 CiteXplore:11149432 CiteXplore:11477488 CiteXplore:11805404 CiteXplore:12622787 CiteXplore:12649306 CiteXplore:12834252 CiteXplore:14561867 CiteXplore:15080725 CiteXplore:16146016 CiteXplore:16317894 CiteXplore:16412483 CiteXplore:16449954 CiteXplore:16601073 CiteXplore:16757377 CiteXplore:16806124 CiteXplore:16818870 CiteXplore:17031479 CiteXplore:17237217 CiteXplore:20669995 CiteXplore:6085021 CiteXplore:7059264 CiteXplore:7161364 CiteXplore:8884658 CiteXplore:9360553 CiteXplore:9422813 CiteXplore:9849813 CiteXplore:9858756 DrugBank:DB00988 HMDB:HMDB00073 KEGG COMPOUND:62-31-7 KEGG COMPOUND:C03758 KEGG DRUG:D07870 KNApSAcK:C00001408 MetaCyc:DOPAMINE PDBeChem:LDP Reaxys:1072822 Wikipedia:Dopamine 4-(2-aminoethyl)benzene-1,2-diol Dopamine chebi_ontology InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 2-(3,4-Dihydroxyphenyl)ethylamine 2-(3,4-dihydroxyphenyl)ethylamine 3,4-Dihydroxyphenethylamine 3,4-Dihydroxyphenylethylamine 3-Hydroxytyramine 4-(2-Aminoethyl)-1,2-benzenediol 4-(2-Aminoethyl)-Pyrocatechol 4-(2-Aminoethyl)benzene-1,2-diol 4-(2-aminoethyl)-1,2-benzenediol 4-(2-aminoethyl)catechol 4-(2-aminoethyl)pyrocatechol 4-(2-azanylethyl)benzene-1,2-diol C8H11NO2 Deoxyepinephrine Dopamin Dopaminum Dopastat Dophamine Dynatra Hydroxytyramin Hydroxytyramine Intropin L-DOPAMINE NCCc1ccc(O)c(O)c1 Oxytyramine Revivan VYFYYTLLBUKUHU-UHFFFAOYSA-N a-(3,4-Dihydroxyphenyl)-b-aminoethane alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane dopamina dopamine dopaminum CHEBI:18243 Dopamine dopamine CHEBI:18243 CHEBI:18295 A 1H-imidazol-4-yl group substituted at position C-4 by a 2-aminoethyl group. CHEBI:14401 CHEBI:24596 CHEBI:43187 CHEBI:817 Beilstein:2012 ChemIDplus:51-45-6 CiteXplore:10511481 CiteXplore:11084298 CiteXplore:11272150 CiteXplore:11603849 CiteXplore:15334189 CiteXplore:15555433 CiteXplore:15610369 CiteXplore:15626750 CiteXplore:15649269 CiteXplore:15725248 CiteXplore:15869544 CiteXplore:16354198 CiteXplore:16365391 CiteXplore:16399866 CiteXplore:16433856 CiteXplore:16689187 CiteXplore:16760908 CiteXplore:19212411 CiteXplore:19309105 CiteXplore:19547708 CiteXplore:19843401 CiteXplore:2013627 CiteXplore:22770225 CiteXplore:24101735 CiteXplore:6839633 CiteXplore:7164933 CiteXplore:9303324 Gmelin:2968 HMDB:HMDB00870 KEGG COMPOUND:51-45-6 KEGG COMPOUND:C00388 KEGG DRUG:D08040 KNApSAcK:C00001414 MetaCyc:HISTAMINE NIST Chemistry WebBook:51-45-6 PDBeChem:HSM Reaxys:2012 Wikipedia:Histamine 2-(1H-imidazol-4-yl)ethanamine HISTAMINE Histamine chebi_ontology InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) 1H-Imidazole-4-ethanamine 2-(1H-Imidazol-4-yl)ethanamine 2-(1H-Imidazol-4-yl)ethylamine 2-(1H-imidazol-4-yl)ethan-1-amine 2-(1H-imidazol-5-yl)ethanamine 2-(1H-imidazol-5-yl)ethylamine 2-(4-Imidazolyl)ethanamine 2-(4-Imidazolyl)ethylamine 2-Imidazol-4-yl-Ethylamine 2-Imidazol-4-ylethylamine 4-(2-Aminoethyl)-1H-imidazole 4-(2-Aminoethyl)imidazole 4-Imidazoleethylamine 5-Imidazoleethylamine C5H9N3 Eramin Ergamine Ergotidine Free histamine HSM L-Histamin base L-Histamine NCCc1c[nH]cn1 NTYJJOPFIAHURM-UHFFFAOYSA-N Theramine b-Imidazolyl-4-ethylamine beta-Aminoethylglyoxaline beta-Aminoethylimidazole beta-Aminothethylglyoxaline beta-Imidazolyl-4-ethylamine CHEBI:18295 Histamine histamine CHEBI:18295 CHEBI:18303 A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine. CHEBI:14801 CHEBI:26041 CHEBI:8137 CiteXplore:10540156 CiteXplore:15533308 CiteXplore:19687511 CiteXplore:23543734 CiteXplore:3106116 CiteXplore:3196084 CiteXplore:4153523 CiteXplore:8204602 CiteXplore:8626656 CiteXplore:9677350 DrugBank:DB00144 HMDB:HMDB14291 KEGG COMPOUND:C02737 MetaCyc:L-1-PHOSPHATIDYL-SERINE Patent:EP2322184 Patent:HK1046237 Patent:US2011098249 Wikipedia:Phosphatidylserine chebi_ontology C8H12NO10PR2 N[C@@H](COP(O)(=O)OCC(COC([*])=O)OC([*])=O)C(O)=O PS Phosphatidylserine Ptd-L-Ser phosphatidyl-L-serines CHEBI:18303 phosphatidyl-L-serine CHEBI:18303 CHEBI:18357 The R-enantiomer of noradrenaline. CHEBI:1 CHEBI:14668 CHEBI:25592 CHEBI:258884 CHEBI:43725 Beilstein:2804840 Beilstein:4231961 CAS:51-41-2 DrugBank:DB00368 Drug_Central:1960 HMDB:HMDB00216 KEGG:C00547 KEGG:D00076 KNApSAcK:C00001424 PDBeChem:LNR PDBeChem:LT4 Reaxys:2804840 Wikipedia:Norepinephrine 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol chebi_ontology (-)-arterenol (-)-noradrenaline (-)-norepinephrine (R)-(-)-norepinephrine (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol (R)-norepinephrine 0 169.074 169.17780 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol Arterenol C8H11NO3 InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 L-NOREPINEPHRINE L-Noradrenaline NC[C@H](O)c1ccc(O)c(O)c1 Noradrenaline Norepinephrine SFLSHLFXELFNJZ-QMMMGPOBSA-N norepinefrina norepinephrine norepinephrinum CHEBI:18357 (R)-noradrenaline CHEBI:18357 CHEBI:18397 A phenylethylamine having the phenyl substituent at the 2-position. CHEBI:14782 CHEBI:25965 CHEBI:8063 Beilstein:507488 ChemIDplus:64-04-0 CiteXplore:12205654 CiteXplore:20390105 CiteXplore:21191624 CiteXplore:21690383 CiteXplore:23225177 CiteXplore:23564683 CiteXplore:7360842 CiteXplore:7906896 CiteXplore:7918350 DrugBank:DB04325 ECMDB:ECMDB02654 Gmelin:50120 HMDB:HMDB12275 KEGG COMPOUND:64-04-0 KEGG COMPOUND:C05332 KNApSAcK:C00001426 MetaCyc:PHENYLETHYLAMINE NIST Chemistry WebBook:64-04-0 PDBeChem:PEA Reaxys:507488 Wikipedia:2-phenylethylamine 2-Phenylethylamine 2-phenylethanamine chebi_ontology (2-Aminoethyl)benzene (2-Aminoethyl)polystyrene 1-Amino-2-phenylethane 1-Phenethylamine 1-Phenyl-2-amino-athan 1-Phenyl-2-amino-athan (GERMAN) 1-Phenyl-2-amino-athan [German] 1-Phenyl-2-aminoethane 1tnj 1utm 1uto 2-Amino-1-phenylethane 2-Amino-fenylethan 2-Amino-fenylethan [Czech] 2-Fenylethylamin 2-Fenylethylamin [Czech] 2-Phenethylamine 2-Phenyl-Ethanamine 2-Phenylethanamine (ACD/Name 4.0) 2-Phenylethylamine (ACD/Name 4.0) 2-phenylethan-1-amine 2-phenylethanamine BHHGXPLMPWCGHP-UHFFFAOYSA-N Benzeneethanamine hydrochloride C8H11N InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2 NCCc1ccccc1 Omega-phenylethylamine PEA Phenethylamine Phenethylamine hydrochloride Phenylethylamine Polystyrene A-NH2 b-Aminoethylbenzene b-Phenethylamine b-Phenylaethylamin b-Phenylaethylamin (german) b-Phenylethylamine benzeneethanamine beta Phenethylamine beta-Phenylaethylamin beta-Phenylaethylamin (german) beta-Phenylaethylamin [german] beta-Phenylethylamine beta-aminoethylbenzene beta-phenethylamine CHEBI:18397 2-phenylethylamine Beta-phenylethylamine CHEBI:18397 CHEBI:18420 A magnesium cation that has formula Mg. CHEBI:13379 CHEBI:25112 CHEBI:49736 CHEBI:6635 ChemIDplus:22537-22-0 CiteXplore:14734878 CiteXplore:14756024 CiteXplore:14770022 CiteXplore:14979638 CiteXplore:15059297 CiteXplore:15116072 CiteXplore:15167956 CiteXplore:15243474 CiteXplore:15262910 CiteXplore:15310301 CiteXplore:15323205 CiteXplore:15552844 CiteXplore:15584394 CiteXplore:15585675 CiteXplore:15967566 CiteXplore:15999464 CiteXplore:16052852 CiteXplore:16244393 CiteXplore:16419627 CiteXplore:16548140 CiteXplore:16732795 CiteXplore:22546835 CiteXplore:24023812 Gmelin:6857 HMDB:HMDB00547 KEGG COMPOUND:C00305 MetaCyc:13-HYDROXY-MAGNESIUM-PROTOPORP NIST Chemistry WebBook:22537-22-0 PDBeChem:MG Wikipedia:Magnesium magnesium cation magnesium(2+) magnesium(2+) ion magnesium(II) cation chebi_ontology InChI=1S/Mg/q+2 JLVVSXFLKOJNIY-UHFFFAOYSA-N MAGNESIUM ION Magnesium ions Mg Mg(2+) Mg2+ [Mg++] magnesium magnesium, doubly charged positive ion magnesium, ion (Mg(2+)) CHEBI:18420 magnesium(2+) CHEBI:18420 CHEBI:20067 A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics. Beilstein:773861 ChemIDplus:300-85-6 CiteXplore:10855969 CiteXplore:11043913 CiteXplore:1126459 CiteXplore:11571605 CiteXplore:11701757 CiteXplore:12067838 CiteXplore:12098531 CiteXplore:12149510 CiteXplore:15363641 CiteXplore:16540841 CiteXplore:17190852 CiteXplore:17579249 CiteXplore:18502700 CiteXplore:2026685 CiteXplore:24029555 CiteXplore:3884391 CiteXplore:6061736 CiteXplore:7051864 CiteXplore:8412012 CiteXplore:8579834 CiteXplore:8969283 CiteXplore:9357925 CiteXplore:9693263 HMDB:HMDB00357 LIPID MAPS:LMFA01050005 MetaCyc:CPD-335 Reaxys:773861 Wikipedia:3-Hydroxybutyric acid Wikipedia:3-hydroxybutyrate 3-hydroxybutanoic acid 3-hydroxybutyric acid chebi_ontology InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7) (1)-3-Hydroxybutyric acid 3 HBA 3-Hydroxy-butanoate 3-Hydroxy-butanoic acid 3-Hydroxy-butyrate 3-Hydroxy-butyric acid 3-Hydroxybutanoate 3-Hydroxybuttersaeure 3-Hydroxybutyrate 3-OH-butyric acid 3-hydroxybutanoic acid BHBA Biopol C4H8O3 CC(O)CC(O)=O DL-3-Hydroxybutyrate DL-b-Hydroxybutyric acid DL-beta-Hydroxybutyric acid WHBMMWSBFZVSSR-UHFFFAOYSA-N b-Hydroxy-N-butyrate b-Hydroxy-N-butyric acid b-Hydroxybutanoate b-Hydroxybutanoic acid b-Hydroxybutyrate b-Hydroxybutyric acid beta-Hydroxy-N-butyrate beta-Hydroxy-n-butyric acid beta-Hydroxybutanoate beta-Hydroxybuttersaeure beta-Hydroxybutyrate beta-hydroxy-n-butyric acid beta-hydroxybutanoic acid beta-hydroxybutyric acid CHEBI:20067 3-hydroxybutyric acid Beta-D-hydroxybutyric acid CHEBI:20067 CHEBI:22563 A monoatomic or polyatomic species having one or more elementary charges of the electron. Anion anion chebi_ontology . Anionen aniones anions CHEBI:22563 Anion anion CHEBI:22563 Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. molecular entity chebi_ontology . entidad molecular entidades moleculares entite moleculaire molecular entities molekulare Entitaet CHEBI:23367 Molecular entity molecular entity CHEBI:23367 A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. chemical entity chebi_ontology . grouped_by_chemistry CHEBI:24431 Chemical entity chemical entity CHEBI:24431 CHEBI:24432 A role played by the molecular entity or part thereof within a biological context. chebi_ontology biological function CHEBI:24432 biological role Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u. chebi_ontology CHEBI:24636 proton CHEBI:24636 A molecular entity having a net electric charge. Ion ion chebi_ontology . Ionen iones ions CHEBI:24870 Ion ion CHEBI:24870 CHEBI:2700 An N-(polyunsaturated fatty acyl)ethanolamine resulting from the formal condensation of carboxy group of arachidonic acid with amino group of ethanolamine. CHEBI:88116 Beilstein:7079463 ChemIDplus:94421-68-8 CiteXplore:15047233 CiteXplore:15797258 CiteXplore:15997233 CiteXplore:16118355 CiteXplore:16957004 CiteXplore:18691603 CiteXplore:19330032 CiteXplore:19817812 CiteXplore:8814296 HMDB:HMDB04080 KEGG COMPOUND:94421-68-8 KEGG COMPOUND:C11695 LIPID MAPS:LMFA08040001 MetaCyc:CPD-7598 Reaxys:7079463 Wikipedia:Anandamide (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide Anandamide chebi_ontology (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide (all-Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15- N-(2-Hydroxyethyl)-5,8,11,14-Eicosatetraenamide (all-Z) 5,8,11,14-Eicosatetraenoylethanolamide AEA Anandamide (20.4, N-6) Anandamide(20:4, N-6) Arachidonic acid N-(hydroxyethyl)amide Arachidonylethanolamide C(CCC)C/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCO)=O C22H37NO2 LGEQQWMQCRIYKG-DOFZRALJSA-N N-(2-Hydroxyethyl)anachidonamide N-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-ethanolamine N-(5Z,8Z,11Z,14Z-eicosatetraenoyl) ethanolamine N-(5Z,8Z,11Z,14Z-icosatetraenoyl)-ethanolamide N-arachidonoyl ethanolamine N-arachidonoyl-2-hydroxyethylamide N-arachidonoylethanolamine arachidonoyl ethanolamide CHEBI:2700 Anandamide anandamide CHEBI:2700 CHEBI:27385 A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups. CHEBI:23015 CHEBI:3400 Beilstein:1098295 CAS:56-23-5 Drug_Central:3067 Gmelin:2347 HMDB:HMDB31330 KEGG:C07561 LINCS:LSM-37019 PMID:24395137 PMID:24726765 Reaxys:1098295 UM-BBD_compID:c0486 Wikipedia:Carbon_Tetrachloride Tetrachloromethane tetrachloromethane chebi_ontology 0 151.875 153.82300 CCl4 Carbon tetrachloride ClC(Cl)(Cl)Cl InChI=1S/CCl4/c2-1(3,4)5 Kohlenstofftetrachlorid Tetra Tetrachlorkohlenstoff Tetrachlormethan VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloridocarbon CHEBI:27385 tetrachloromethane CHEBI:27385 CHEBI:27432 A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect. CHEBI:10298 CHEBI:22462 CHEBI:43891 Beilstein:1727693 CAS:463-40-1 DrugBank:DB00132 Drug_Central:4618 Gmelin:57558 HMDB:HMDB01388 KEGG:C06427 KNApSAcK:C00007247 LIPID_MAPS_instance:LMFA01030152 MetaCyc:LINOLENIC_ACID PDBeChem:LNL PMID:10232625 PMID:11304127 PMID:19269799 PMID:24320056 PMID:24639012 PMID:24855655 Reaxys:1727693 Wikipedia:Alpha-Linolenic_acid (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid ALPHA-LINOLENIC ACID alpha-Linolenic acid alpha-linolenic acid chebi_ontology (9,12,15)-linolenic acid (9Z,12Z,15Z)-Octadecatrienoic acid (Z,Z,Z)-9,12,15-octadecatrienoic acid 0 278.225 278.42960 9,12,15-Octadecatrienoic acid 9-cis,12-cis,15-cis-octadecatrienoic acid ALA C18H30O2 CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9- all-cis-9,12,15-octadecatrienoic acid cis,cis,cis-9,12,15-octadecatrienoic acid cis-Delta(9,12,15)-octadecatrienoic acid linolenic acid CHEBI:27432 alpha-linolenic acid CHEBI:27432 CHEBI:27485 A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer). CHEBI:26332 CHEBI:8521 CAS:60203-57-8 HMDB:HMDB02710 KEGG:C05957 LIPID_MAPS_instance:LMFA03010019 PMID:12213491 Reaxys:8353080 (5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid Prostaglandin J2 chebi_ontology 0 334.214 334.44980 9-Deoxy-delta-9-pgd2 9-Deoxy-delta-9-prostaglandin D2 C20H30O4 CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 PGJ2 UQOQENZZLBSFKO-POPPZSFYSA-N CHEBI:27485 prostaglandin J2 CHEBI:27485 CHEBI:28209 A HETE having a (5S)-hydroxy group and (6E)-, (8Z)-, (11Z)- and (14Z)-double bonds. CHEBI:20581 CHEBI:2068 Beilstein:4691533 CAS:70608-72-9 HMDB:HMDB11134 KEGG:C04805 KNApSAcK:C00000423 LIPID_MAPS_instance:LMFA03060002 PMID:10987416 PMID:3460103 PMID:3592413 Reaxys:4691533 Wikipedia:5-Hydroxyeicosatetraenoic_acid (5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid 5(S)-HETE chebi_ontology (5S,6E,8Z,11Z,14Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid (S)-(E,Z,Z,Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid 0 320.235 320.46628 5(S)-hydroxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid 5(S)-hydroxyeicosatetraenoic acid 5-Hydroxyeicosatetraenoate 5S-HETE 6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (S-(E,Z,Z,Z))- C20H32O3 CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1 KGIJOOYOSFUGPC-JGKLHWIESA-N CHEBI:28209 5(S)-HETE CHEBI:28209 CHEBI:28666 A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R). CHEBI:25026 CHEBI:6423 CAS:73836-78-9 HMDB:HMDB03080 KEGG:C05951 LIPID_MAPS_instance:LMFA03020006 PMID:23825762 PMID:9160411 Reaxys:4726738 Wikipedia:Leukotriene_D4 Leukotriene D4 S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteinylglycine chebi_ontology (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine 0 496.261 496.66000 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid C25H40N2O6S CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 LTD4 YEESKJGWJFYOOK-IJHYULJSSA-N CHEBI:28666 leukotriene D4 CHEBI:28666 CHEBI:28790 A primary amino compound that is the 5-hydroxy derivative of tryptamine. CHEBI:1420 CHEBI:26652 CHEBI:49894 Beilstein:143524 ChemIDplus:50-67-9 CiteXplore:10367709 CiteXplore:12834252 CiteXplore:12912814 CiteXplore:16047543 CiteXplore:16289360 CiteXplore:16366421 CiteXplore:16412483 CiteXplore:16435178 CiteXplore:16515859 CiteXplore:16516555 CiteXplore:16580588 CiteXplore:16652315 CiteXplore:16842443 CiteXplore:16884454 CiteXplore:1691117 CiteXplore:16939882 CiteXplore:18593914 CiteXplore:21939218 CiteXplore:22770225 CiteXplore:24136337 CiteXplore:2459577 CiteXplore:2580417 CiteXplore:8884658 CiteXplore:9849813 CiteXplore:9931050 Gmelin:1861995 HMDB:HMDB00259 KEGG COMPOUND:50-67-9 KEGG COMPOUND:C00780 KNApSAcK:C00001429 MetaCyc:SEROTONIN PDBeChem:SRO Reaxys:143524 Wikipedia:Serotonin 3-(2-aminoethyl)-1H-indol-5-ol SEROTONIN Serotonin chebi_ontology InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 3-(2-Aminoethyl)-1H-indol-5-ol 3-(2-Aminoethyl)indol-5-ol 3-(2-azanylethyl)-1H-indol-5-ol 3-(b-Aminoethyl)-5-hydroxyindole 5-HT 5-HTA 5-Hydroxy-3-(b-aminoethyl)indole 5-Hydroxyltryptamine 5-Hydroxytriptamine 5-Hydroxytryptamine 5-hydroxy-tryptamine Antemoqua Antemovis C10H12N2O DS substance Enteramin Enteramine Hippophaine NCCc1c[nH]c2ccc(O)cc12 QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonine thrombocytin thrombotonin CHEBI:28790 serotonin CHEBI:28790 CHEBI:28834 A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively. CHEBI:1687 CHEBI:23616 CHEBI:42317 Beilstein:3219882 CAS:83-44-3 DrugBank:DB03619 Drug_Central:4988 Gmelin:670078 KEGG:C04483 KNApSAcK:C00030117 LINCS:LSM-5529 LIPID_MAPS_instance:LMST04010040 PDBeChem:DXC 3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid Deoxycholic acid chebi_ontology (3ALPHA,5ALPHA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID (3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid 0 392.293 392.57200 3alpha,12alpha-Dihydroxy-5beta-cholanic acid 7alpha-deoxycholic acid C24H40O4 Desoxycholsaeure InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1 KXGVEGMKQFWNSR-LLQZFEROSA-N [H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2 desoxycholic acid CHEBI:28834 deoxycholic acid CHEBI:28834 CHEBI:28918 The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response. CHEBI:1942 CHEBI:23928 Beilstein:2368277 ChemIDplus:51-43-4 CiteXplore:10349032 CiteXplore:10556286 CiteXplore:11642745 CiteXplore:12121816 CiteXplore:12649306 CiteXplore:12834252 CiteXplore:12851650 CiteXplore:1347802 CiteXplore:15123562 CiteXplore:15300253 CiteXplore:15579180 CiteXplore:16705573 CiteXplore:16777916 CiteXplore:16840834 CiteXplore:18325983 CiteXplore:2159374 CiteXplore:21963816 CiteXplore:22115931 CiteXplore:22405854 CiteXplore:22425731 CiteXplore:22429969 CiteXplore:22569014 CiteXplore:22623754 CiteXplore:22826982 CiteXplore:22895980 CiteXplore:22898765 CiteXplore:22905594 CiteXplore:22940899 CiteXplore:23066296 CiteXplore:23130169 CiteXplore:23164182 CiteXplore:23185846 CiteXplore:3122251 CiteXplore:7704967 CiteXplore:7769131 CiteXplore:9269942 CiteXplore:9327880 CiteXplore:9384611 CiteXplore:9626157 CiteXplore:9931050 DrugBank:DB00668 HMDB:HMDB00068 KEGG COMPOUND:51-43-4 KEGG COMPOUND:C00788 KEGG DRUG:D00095 KNApSAcK:C00029643 MetaCyc:L-EPINEPHRINE NIST Chemistry WebBook:51-43-4 Reaxys:2368277 Wikipedia:Epinephrine 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol (R)-Adrenaline chebi_ontology (-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol (-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol (-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol (-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol (-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol (R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol 4-[(1R)-1-hydroxy-2-methylamino-ethyl]benzene-1,2-diol 4-[(1R)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1 (-)-(R)-epinephrine (-)-Epinephrine (-)-adrenaline (R)-(-)-Adnephrine (R)-(-)-Adrenaline (R)-(-)-Epinephrine (R)-(-)-Epirenamine (R)-(-)-adrenaline (R)-Epinephrine 4-[(1R)-1-hydroxy-2-methylamino-ethyl]pyrocatechol Adnephrine Adrenal Adrenalin Adrenine Adrin Ana-Kit Bosmin Bronkaid Mist C9H13NO3 CNC[C@H](O)c1ccc(O)c(O)c1 Chelafrin Epifrin Epiglaufrin Epinefrina Epinephran Epinephrin Epipen Epipen JR Epirenan Eppy Exadrin Glauposine Hemisine Hemostasin Hemostatin Hypernephrin Isoptoepinal L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol L-Adrenaline L-Epinephrine L-Epirenamine L-Methylaminoethanolcatechol Levorenen Levorenin Levorenine Levoreninum Lyodrin Methylarterenol Mucidrina Nephridine Nieraline Paranephrin Primatene Primatene Mist R-(-)-Epinephrine Renaglandin Renaleptine Renalina Renoform Renostypticin Renostyptin Scurenaline Simplene Styptirenal Supracapsulin Supranephrane Suprarenaline Suprarenin Surrenine Sus-phrine Takamina UCTWMZQNUQWSLP-VIFPVBQESA-N Vasoconstrictine Vasotonin adrenaline epinefrina epinephrine epinephrinum levoepinephrine CHEBI:28918 (R)-adrenaline CHEBI:28918 CHEBI:29101 A monoatomic monocation obtained from sodium. CHEBI:26717 CHEBI:49766 CHEBI:9175 ChemIDplus:17341-25-2 CiteXplore:10378074 CiteXplore:16572107 CiteXplore:16580612 CiteXplore:17066056 CiteXplore:22546835 CiteXplore:24023812 Gmelin:15196 HMDB:HMDB00588 KEGG COMPOUND:C01330 NIST Chemistry WebBook:17341-25-2 PDBeChem:NA Wikipedia:Sodium sodium cation sodium(1+) sodium(1+) ion sodium(I) cation chebi_ontology FKNQFGJONOIPTF-UHFFFAOYSA-N InChI=1S/Na/q+1 Na Na(+) Na+ SODIUM ION [Na+] sodium CHEBI:29101 sodium(1+) CHEBI:29101 CHEBI:29103 A monoatomic monocation obtained from potassium. CHEBI:26219 CHEBI:49685 CHEBI:8345 CiteXplore:11401244 CiteXplore:17883675 CiteXplore:1893277 CiteXplore:24023812 CiteXplore:297449 CiteXplore:9263178 Gmelin:15203 HMDB:HMDB00586 KEGG COMPOUND:C00238 KEGG DRUG:D08403 MetaCyc:K%2b NIST Chemistry WebBook:24203-36-9 PDBeChem:K Wikipedia:Potassium Potassium(1+) potassium cation potassium(1+) potassium(1+) ion potassium(I) cation chebi_ontology InChI=1S/K/q+1 K K(+) K+ Kalium NPYPAHLBTDXSSS-UHFFFAOYSA-N POTASSIUM ION Potassium (K+) Potassium (ion) Potassium cation Potassium ion (K+) Potassium ion (K1+) Potassium ion(+) Potassium ion(1+) Potassium monocation Potassium(+) Potassium(1+) ion [K+] potassium CHEBI:29103 potassium(1+) CHEBI:29103 CHEBI:29105 CHEBI:10113 CHEBI:27368 CHEBI:49972 CHEBI:49982 CAS:23713-49-7 Gmelin:6869 KEGG:C00038 PDBeChem:ZN zinc(2+) zinc(2+) ion zinc(II) cation chebi_ontology +2 63.929 65.39000 InChI=1S/Zn/q+2 PTFCDOFLOPIGGS-UHFFFAOYSA-N ZINC ION Zn Zn(2+) Zn(II) Zn2+ [Zn++] dietary zinc zinc cation zinc, ion (Zn2+) CHEBI:29105 zinc(2+) CHEBI:29105 CHEBI:29108 A calcium cation that has formula Ca. CHEBI:22988 CHEBI:3308 CHEBI:48760 ChemIDplus:14127-61-8 CiteXplore:11683549 CiteXplore:15671236 CiteXplore:15860827 CiteXplore:15885294 CiteXplore:16034903 CiteXplore:16244393 CiteXplore:16481635 CiteXplore:16704554 CiteXplore:16718844 CiteXplore:22546835 CiteXplore:24023812 CiteXplore:297449 CiteXplore:9278463 Gmelin:6850 HMDB:HMDB00464 KEGG COMPOUND:C00076 MetaCyc:CA%2b2 NIST Chemistry WebBook:14127-61-8 PDBeChem:CA Wikipedia:Calcium calcium(2+) calcium(2+) ion calcium(II) cation chebi_ontology BHPQYMZQTOCNFJ-UHFFFAOYSA-N CALCIUM ION Ca Ca(2+) Ca2+ Calcium element InChI=1S/Ca/q+2 [Ca++] calcium calcium, doubly charged positive ion CHEBI:29108 calcium(2+) CHEBI:29108 CHEBI:29947 CHEBI:13347 CHEBI:29946 CHEBI:42772 PDBeChem:GLY_LL RESID:AA0008 glycine residue chebi_ontology -Gly- -HN-CH2-CO- 0 57.021 57.05136 C2H3NO G glycine glycyl CHEBI:29947 glycine residue CHEBI:29972 RESID:AA0006 L-glutamic acid residue chebi_ontology -Glu- 0 129.043 129.11402 C5H7NO3 E Glu L-glutamic acid L-glutamic residue L-glutamyl CHEBI:29972 L-glutamic acid residue CHEBI:29997 RESID:AA0014 L-phenylalanine residue chebi_ontology -Phe- 0 147.068 147.17390 C9H9NO F L-phenylalanine L-phenylalanyl Phe CHEBI:29997 L-phenylalanine residue CHEBI:29999 A serine residue that has L configuration. RESID:AA0016 L-serine residue chebi_ontology -Ser- 0 87.032 87.07734 C3H5NO2 L-serine L-seryl S Ser CHEBI:29999 L-serine residue CHEBI:30006 RESID:AA0011 L-leucine residue chebi_ontology -Leu- 0 113.084 113.15768 C6H11NO L L-leucine L-leucyl Leu CHEBI:30006 L-leucine residue CHEBI:30009 RESID:AA0010 L-isoleucine residue chebi_ontology -Ile- 0 113.084 113.15768 C6H11NO I Ile L-isoleucine L-isoleucyl CHEBI:30009 L-isoleucine residue CHEBI:30011 RESID:AA0007 L-glutamine residue chebi_ontology -Gln- 0 128.059 128.12930 C5H8N2O2 Gln Glu(NH2) L-glutamine L-glutaminyl Q CHEBI:30011 L-glutamine residue CHEBI:30013 RESID:AA0017 L-threonine residue chebi_ontology -Thr- 0 101.048 101.10392 C4H7NO2 L-threonine L-threonyl T Thr CHEBI:30013 L-threonine residue CHEBI:30015 RESID:AA0020 L-valine residue chebi_ontology -Val- 0 99.068 99.13110 C5H9NO L-valine L-valyl V Val CHEBI:30015 L-valine residue CHEBI:30623 A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of oxalic acid. CHEBI:14702 CHEBI:25729 CHEBI:44820 Beilstein:1905970 ChEBI:C00209 ChemIDplus:338-70-5 Gmelin:2207 PDBeChem:OXL Reaxys:1905970 UM-BBD:c0017 ethanedioate chebi_ontology C2O4 InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 MUBZPKHOEPUJKR-UHFFFAOYSA-L OXALATE ION [O-]C(=O)C([O-])=O ethanedioic acid, ion(2-) ox oxalate CHEBI:30623 oxalate(2-) CHEBI:30623 CHEBI:30736 trichloromethyl chebi_ontology -CCl3 0 116.907 118.36880 CCl3 CHEBI:30736 trichloromethyl group CHEBI:30736 CHEBI:3165 A linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation. ChemIDplus:58-82-2 CiteXplore:11975815 CiteXplore:13446366 CiteXplore:18127230 CiteXplore:19212411 HMDB:HMDB04246 KEGG COMPOUND:C00306 L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine Bradykinin chebi_ontology (2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{[(2S)-1-{[(2S)-1-[(2S)-2-amino-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]carbonyl}pyrrolidin-2-yl]formamido}acetamido)-3-phenylpropanamido]-3-hydroxypropanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-carbamimidamidopentanoic acid InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1 L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-Arginine N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O BK C50H73N15O11 Callidin I Kallidin 9 Kallidin I L-bradykinin QXZGBUJJYSLZLT-FDISYFBBSA-N CHEBI:3165 Bradykinin bradykinin CHEBI:3165 CHEBI:32952 A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. CHEBI:13814 CHEBI:22474 CHEBI:2641 KEGG COMPOUND:C00706 KEGG:C00706 Amine amines chebi_ontology . Amin N[*] Substituted amine an amine CHEBI:32952 Amine amine CHEBI:32952 CHEBI:3306 A 32-membered heterodetic cyclic peptide comprising the sequence Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 cyclised by a disulfide bridge between the two Cys residues at positions 1 and 7. CAS:47931-85-1 CAS:9007-12-9 DrugBank:DB00017 Drug_Central:2989 KEGG:C06865 KEGG:D00249 Reaxys:8186880 Wikipedia:Calcitonin Calcitonin N-{[(4R,7S,10S,13S,16S,19S,22R)-22-amino-16-(2-amino-2-oxoethyl)-7-[(1R)-1-hydroxyethyl]-10,19-bis(hydroxymethyl)-13-isobutyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosan-4-yl]carbonyl}-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-L-prolinamide chebi_ontology 0 3429.713 3431.85300 BBBFJLBPOGFECG-VJVYQDLKSA-N C145H240N44O48S2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(N)=O Calcitonin, salmon Cibacalcin InChI=1S/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)/t71-,72-,73-,74-,75-,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,110+,111+,112+,113+,114+,115+/m1/s1 Salmon calcitonin Salmon calcitonin-(1-32) Salmotonin Thyrocalcitonin (salmon) calcitonin cyclo-[Cys-Ser-Asn-Leu-Ser-Thr-Cys]-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 CHEBI:3306 calcitonin CHEBI:3306 CHEBI:33569 A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted. Beilstein:2210994 ChemIDplus:138-65-8 Gmelin:863925 NIST Chemistry WebBook:138-65-8 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol chebi_ontology InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 C8H11NO3 NCC(O)c1ccc(O)c(O)c1 SFLSHLFXELFNJZ-UHFFFAOYSA-N noradrenalina norepinephrine CHEBI:33569 Noradrenaline noradrenaline CHEBI:33569 CHEBI:33575 A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. CHEBI:13428 CHEBI:13627 CHEBI:23027 CiteXplore:17147560 CiteXplore:18433345 Wikipedia:Carboxylic_acid carboxylic acid carboxylic acids chebi_ontology CHO2R Carbonsaeure Carbonsaeuren Karbonsaeure OC([*])=O RC(=O)OH acide carboxylique acides carboxyliques acido carboxilico acidos carboxilicos CHEBI:33575 Carboxylic acid carboxylic acid CHEBI:33575 CHEBI:33700 chebi_ontology canonical amino-acid residue canonical amino-acid residues common amino acid residues proteinogenic amino-acid residues standard amino acid residues standard amino-acid residues CHEBI:33700 proteinogenic amino-acid residue CHEBI:33709 A carboxylic acid containing one or more amino groups. A carboxylic acid containing one or more amino groups. CHEBI:13815 CHEBI:22477 Wikipedia:Amino_acid chebi_ontology . Aminocarbonsaeure Aminokarbonsaeure Aminosaeure amino acids CHEBI:33709 Amino acid amino acid CHEBI:33709 CHEBI:33838 An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents. CHEBI:13661 CHEBI:25611 CHEBI:7647 KEGG COMPOUND:C00801 Nucleoside nucleosides chebi_ontology C5H9O4R OC[C@H]1O[C@@H]([*])[C@H](O)[C@@H]1O a nucleoside nucleosides CHEBI:33838 Nucleoside nucleoside CHEBI:33838 CHEBI:34144 A HETE having a (12R)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds. CiteXplore:2495992 CiteXplore:2517876 CiteXplore:3026490 CiteXplore:9044430 KEGG COMPOUND:C14822 KNApSAcK:C00000424 LIPID MAPS:LMFA03060008 Reaxys:4234647 Reaxys:82337-46-0 (5Z,8Z,10E,12R,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid 12(R)-HETE chebi_ontology (5Z,8Z,10E,12R,14Z)-12-hydroxy-5,8,10,14-eicosatetraenoic acid (5Z,8Z,10E,12R,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid (5Z,8Z,10E,14Z)-(12R)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid (5Z,8Z,10E,14Z)-(12R)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid 12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid 12(R)-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m1/s1 12(R)-hydroxyeicosatetraenoic acid 12R-HETE C20H32O3 CCCCC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O ZNHVWPKMFKADKW-ZYBDYUKJSA-N CHEBI:34144 12(R)-HETE 12R-HETE CHEBI:34144 CHEBI:34146 A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds. Beilstein:2656104 CAS:54397-83-0 KEGG:C14777 KNApSAcK:C00000424 LIPID_MAPS_instance:LMFA03060007 PMID:10952974 PMID:11158968 PMID:11726629 PMID:11756509 PMID:12697425 PMID:15105833 PMID:17963719 PMID:2517876 PMID:25449650 PMID:3026490 PMID:7492988 PMID:7511046 PMID:7540838 PMID:7593207 PMID:7683691 PMID:7688315 Reaxys:2656104 (5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid 12(S)-HETE chebi_ontology (12S)-12-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid (5Z,8Z,10E,12S,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid (5Z,8Z,10E,14Z)-(12S)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid (5Z,8Z,10E,14Z)-(12S)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid 0 12(S)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid 12(S)-hydroxy-5,8,14(Z),10(E)-eicosatetraenoic acid 12(S)-hydroxyeicosatetraenoic acid 12S-HETE 320.235 320.46628 C20H32O3 CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 ZNHVWPKMFKADKW-LQWMCKPYSA-N CHEBI:34146 12(S)-HETE CHEBI:34146 CHEBI:34972 KEGG COMPOUND:1393-25-5 KEGG COMPOUND:17034-35-4 KEGG COMPOUND:C13523 KEGG DRUG:D02021 Secretin chebi_ontology CC(C)CC(NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(C)NC(=O)C([*])NC(=O)C(C[*])NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)Cc1ncc[nH]1)C(C)O)C(C)O)C(=O)NC(C(C)C)C(N)=O C130H220N44O41 Vitrum CHEBI:34972 Secretin CHEBI:34972 CHEBI:36005 Any C22 polyunsaturated fatty acid containing six double bonds. docosahexaenoic acid chebi_ontology C22H32O2 DHA docosahexaenoic acids CHEBI:36005 Docosahexaenoic acid docosahexaenoic acid CHEBI:36005 CHEBI:36914 chebi_ontology . inorganic ions CHEBI:36914 Inorganic ion inorganic ion CHEBI:36914 CHEBI:36916 A monoatomic or polyatomic species having one or more elementary charges of the proton. CHEBI:23058 CHEBI:3473 KEGG COMPOUND:C01373 Cation cation chebi_ontology . Kation Kationen cationes cations CHEBI:36916 Cation cation CHEBI:36916 CHEBI:36976 A nucleotide is a nucleoside phosphate. It is a phosphate ester that has a nucleoside moiety and has at least one phosphate moiety attached to the C-5 carbon of the ribose or deoxyribose moiety. A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid. CHEBI:13215 CHEBI:13663 CHEBI:7656 KEGG COMPOUND:C00215 KEGG:C00215 Nucleotide chebi_ontology a nucleotide nucleotides CHEBI:36976 Nucleotide nucleotide CHEBI:36976 CHEBI:37098 An 8-carbon, beta-hydroxy fatty acid which may be a marker for primary defects of beta-hydroxy fatty acid metabolism. Repeating unit of poly(3-hydroxyoctanoic acid), a biopolymer used by numerous bacterial species as carbon and energy reserves. Beilstein:1760767 ChemIDplus:14292-27-4 CiteXplore:18422622 CiteXplore:19047387 CiteXplore:3168281 LIPID MAPS:LMFA01050021 3-hydroxyoctanoic acid chebi_ontology InChI=1S/C8H16O3/c1-2-3-4-5-7(9)6-8(10)11/h7,9H,2-6H2,1H3,(H,10,11) 3-OH octanoic acid 3-OH-caprylic acid 3-hydroxy-octanoic acid 3-hydroxycaprylic acid 3HO C8H16O3 CCCCCC(O)CC(O)=O NDPLAKGOSZHTPH-UHFFFAOYSA-N beta-OH-caprylic acid beta-OH-octanoic acid beta-hydroxycaprylic acid beta-hydroxyoctanoic acid CHEBI:37098 3-hydroxyoctanoic acid CHEBI:37098 CHEBI:37550 A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1 CHEBI:26742 CHEBI:9225 Beilstein:5877213 ChemIDplus:26993-30-6 CiteXplore:10544002 CiteXplore:11278407 CiteXplore:11324700 CiteXplore:11331099 CiteXplore:11418470 CiteXplore:11427538 CiteXplore:11470796 CiteXplore:11739995 CiteXplore:12039947 CiteXplore:12062172 CiteXplore:12069819 CiteXplore:12069820 CiteXplore:12069830 CiteXplore:12401202 CiteXplore:12509810 CiteXplore:12586615 CiteXplore:12648236 CiteXplore:12730100 CiteXplore:12742827 CiteXplore:12746430 CiteXplore:12778803 CiteXplore:12796504 CiteXplore:12833634 CiteXplore:12963123 CiteXplore:12963813 CiteXplore:14500646 CiteXplore:14991774 CiteXplore:15044318 CiteXplore:15143482 CiteXplore:15158755 CiteXplore:15258919 CiteXplore:15292266 CiteXplore:15317688 CiteXplore:15326035 CiteXplore:15354862 CiteXplore:15476260 CiteXplore:15567060 CiteXplore:15696050 CiteXplore:15728255 CiteXplore:15734735 CiteXplore:15761190 CiteXplore:15778280 CiteXplore:15992170 CiteXplore:16046448 CiteXplore:16129068 CiteXplore:16148028 CiteXplore:16162874 CiteXplore:16219683 CiteXplore:16243846 CiteXplore:16322129 CiteXplore:16339142 CiteXplore:16434032 CiteXplore:16458188 CiteXplore:16554657 CiteXplore:16673266 CiteXplore:16913663 CiteXplore:16940153 CiteXplore:16956968 CiteXplore:17098744 CiteXplore:17158356 CiteXplore:17220911 CiteXplore:17308123 CiteXplore:17361098 CiteXplore:17374154 CiteXplore:17391120 CiteXplore:17409372 CiteXplore:17517398 CiteXplore:17561264 CiteXplore:17904858 CiteXplore:18155002 CiteXplore:18387885 CiteXplore:18502612 CiteXplore:18541717 CiteXplore:18787560 CiteXplore:18973762 CiteXplore:19081473 CiteXplore:19082500 CiteXplore:19268560 CiteXplore:19293152 CiteXplore:19350109 CiteXplore:19423865 CiteXplore:19556602 CiteXplore:19620297 CiteXplore:19636535 CiteXplore:19662499 CiteXplore:19808013 CiteXplore:19815502 CiteXplore:20671299 CiteXplore:8657285 CiteXplore:9526097 CiteXplore:9668339 HMDB:HMDB00277 KEGG COMPOUND:26993-30-6 KEGG COMPOUND:C06124 LIPID MAPS:LMSP01050001 Reaxys:5877213 Wikipedia:Sphingosine 1-phosphate Wikipedia:Sphingosine-1-phosphate (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate Sphingosine 1-phosphate chebi_ontology (2S,3R,4E)-1-(dihydrogen phosphate)2-amino-4-Octadecene-1,3-diol (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate) InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1 {[(4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acid (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid C18-Sphingosine 1-phosphate C18H38NO5P CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O D-Erythro-Sphingosine-1-phosphate D-erythro-sphingosine 1-phosphate DUYSYHSSBDVJSM-KRWOKUGFSA-N S1P Sphing-4-enine 1-phosphate Sphingosine 1-phosphic acid sphingosine-1-phosphate CHEBI:37550 Sphingosine 1-phosphate sphingosine 1-phosphate CHEBI:37550 CHEBI:46858 CHEBI:29975 CHEBI:46207 PDBeChem:TYR_LL RESID:AA0019 L-tyrosine residue chebi_ontology 0 163.063 163.17330 C9H9NO2 L-tyrosine L-tyrosine acid residue L-tyrosyl Tyr Y CHEBI:46858 L-tyrosine residue CHEBI:4727 CAS:74913-18-1 CAS:80448-90-4 HMDB:HMDB12935 KEGG:C01574 PMID:1716470 Wikipedia:dynorphin_A (2S)-6-amino-2-{[(2S)-1-[(2R)-2-[(2S)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-(2-{2-[(2R)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-3-methylpentanamido]-5-[(azaniumylmethanimidoyl)amino]pentanoyl]pyrrolidin-2-yl]formamido}-N-[(1S)-1-carbamoyl-3-methylbutyl]hexanamide Dynorphin A chebi_ontology +1 1474.912 1475.808 C69H116N23O13 CCC(C)[C@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC=1C=CC=CC1)NC(=O)CNC(=O)CNC(=O)[C@H](N)CC=2C=CC(O)=CC2)C(=O)N[C@H](CCCNC([NH3+])=N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N Dynorphin Dynorphin A 1-17 InChI=1S/C69H115N23O13/c1-7-41(6)56(65(104)88-49(22-15-31-81-69(77)78)66(105)92-32-16-23-53(92)64(103)87-46(19-11-12-28-70)60(99)89-50(57(72)96)33-39(2)3)91-61(100)48(21-14-30-80-68(75)76)85-59(98)47(20-13-29-79-67(73)74)86-62(101)51(34-40(4)5)90-63(102)52(36-42-17-9-8-10-18-42)84-55(95)38-82-54(94)37-83-58(97)45(71)35-43-24-26-44(93)27-25-43/h8-10,17-18,24-27,39-41,45-53,56,93H,7,11-16,19-23,28-38,70-71H2,1-6H3,(H2,72,96)(H,82,94)(H,83,97)(H,84,95)(H,85,98)(H,86,101)(H,87,103)(H,88,104)(H,89,99)(H,90,102)(H,91,100)(H4,73,74,79)(H4,75,76,80)(H4,77,78,81)/p+1/t41?,45-,46+,47-,48-,49-,50+,51-,52-,53+,56+/m1/s1 Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln ZIHYAUCIMOSJIH-QGLXRRFISA-O CHEBI:4727 Dynorphin A CHEBI:4727 CHEBI:48432 ChemIDplus:11128-99-7 CiteXplore:12609766 CiteXplore:1422942 CiteXplore:16075377 CiteXplore:16481883 CiteXplore:16601568 CiteXplore:16672146 CiteXplore:17147923 CiteXplore:18562510 HMDB:HMDB01035 Wikipedia:Angiotensin II chebi_ontology (3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid . 1-8-angiotensin I 1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide Angiotensin 2 Angiotensin II (human) Angiotensin II (mouse) Angiotonin Asp-arg-val-TYR-ile-his-pro-phe Human angiotensin II Hypertensin Ile(5)-angiotensin II ang II angiotensina II angiotensinum II CHEBI:48432 Angiotensin II angiotensin II CHEBI:48432 CHEBI:49713 An alkali metal cation that has formula Li. CHEBI:30143 CHEBI:49711 ChemIDplus:17341-24-1 CiteXplore:16244392 CiteXplore:17288494 CiteXplore:17316163 CiteXplore:17688381 CiteXplore:20453535 CiteXplore:22546835 CiteXplore:24023812 CiteXplore:5256500 CiteXplore:8110911 DrugBank:DB01356 Gmelin:15205 HMDB:HMDB05949 KEGG COMPOUND:7439-93-2 MetaCyc:LI%2b NIST Chemistry WebBook:17341-24-1 PDBeChem:LI lithium(1+) lithium(1+) ion lithium(I) cation chebi_ontology HBBGRARXTFLTSG-UHFFFAOYSA-N InChI=1S/Li/q+1 LITHIUM ION Li Li(+) Li(+) cation Li(+) ion Lithium atom Lithium element Lithium, ion (Li1+) [Li+] lithium lithium cation lithium, ion CHEBI:49713 lithium(1+) CHEBI:49713 CHEBI:50277 A farnesyl phosphate that has formula C15H28O7P2. CHEBI:14231 CHEBI:24016 Beilstein:1892961 DrugBank:DB07780 NIST Chemistry WebBook:13058-04-3 3,7,11-trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate farnesyl diphosphate chebi_ontology InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18) C15H28O7P2 CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-UHFFFAOYSA-N farnesyl diphosphates CHEBI:50277 Farnesyl diphosphate farnesyl diphosphate CHEBI:50277 CHEBI:50347 CHEBI:29956 CHEBI:40859 PDBeChem:ASN_LL RESID:AA0003 L-asparagine residue chebi_ontology -Asn- 0 114.043 114.10272 ASPARAGINE Asn Asp(NH2) C4H6N2O2 L-asparagine L-asparaginyl N CHEBI:50347 L-asparagine residue CHEBI:52392 An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol. CHEBI:34261 CHEBI:52365 ChemIDplus:53847-30-6 CiteXplore:12878451 CiteXplore:15543349 CiteXplore:16278487 CiteXplore:16515464 CiteXplore:16678907 CiteXplore:18771906 CiteXplore:21177788 CiteXplore:21359215 HMDB:HMDB04666 KEGG COMPOUND:53847-30-6 KEGG COMPOUND:C13856 LIPID MAPS:LMGL01010023 MetaCyc:CPD-12600 Reaxys:8167264 Wikipedia:2-Arachidonoylglycerol 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate 2-Arachidonoylglycerol chebi_ontology (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid InChI=1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15- 1-Monoacylglyceride 1-Monoacylglycerol 2-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-rac-glycerol 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol 2-AG 2-Ara-Gl 2-Arachidonoyl-glycerol 2-Arachidonyl glycerol 2-Arachidonyl-glycerol 2-Monoarachidonoylglycerolbeta-monoacylglycerol C23H38O4 MAG(0:0/20:4) MAG(0:0/20:4n6) MAG(0:0/20:4w6) MAG(20:4) MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0) MG(0:0/20:4) MG(0:0/20:4n6) MG(0:0/20:4w6) MG(20:4) RCRCTBLIHCHWDZ-DOFZRALJSA-N [H]C(CO)(CO)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC b-Monoacylglycerol beta-Monoacylglycerol CHEBI:52392 2-arachidonoylglycerol CHEBI:52392 CHEBI:52449 An oxoicosatetraenoic acid having a 5-oxo group; and (6E)-, (8Z), (11Z)- and (14Z)-double bonds. CHEBI:120616 CHEBI:34460 CHEBI:52287 CHEBI:60950 HMDB:HMDB10217 KEGG:C14732 LIPID_MAPS_instance:LMFA03060011 PMID:15893379 PMID:16159627 PMID:19450703 PMID:3599023 PMID:8906847 Reaxys:6213921 (6E,8Z,11Z,14Z)-5-oxoicosa-6,8,11,14-tetraenoic acid chebi_ontology (6E,8Z,11Z,14Z)-5-Oxoicosa-6,8,11,14-tetraenoic acid 0 318.219 318.45040 5-Oxo-icosa-6,8,11,14-tetraenoic acid 5-OxoETE 5-Oxoeicosatetraenoic acid 5-Oxoicosatetraenoic acid 5-keto-ETE 5-ketoeicosatetraenoic acid 5-oxo, 6t,8c,11c,14c-20:4 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid C20H30O3 CCCCC\C=C/C\C=C/C\C=C/C=C/C(=O)CCCC(O)=O InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+ MEASLHGILYBXFO-XTDASVJISA-N eicosa-5,8,12,14-tetraenoic acid CHEBI:52449 5-oxo-ETE CHEBI:52449 CHEBI:53461 chebi_ontology CHEBI:53461 Neuropeptide S neuropeptide S 1 CHEBI:53461 CHEBI:5391 A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence. ChemIDplus:16941-32-5 ChemIDplus:9007-92-5 CiteXplore:21940356 CiteXplore:22014161 CiteXplore:22154917 CiteXplore:22166985 CiteXplore:22167521 CiteXplore:22214853 CiteXplore:22227186 CiteXplore:22286080 CiteXplore:22294753 CiteXplore:22318544 CiteXplore:22334714 CiteXplore:22399501 CiteXplore:22438981 CiteXplore:22454291 DrugBank:DB00040 KEGG COMPOUND:9007-92-5 KEGG COMPOUND:C01501 KEGG DRUG:D00116 Reaxys:13191924 Wikipedia:Glucagon L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine Glucagon chebi_ontology CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 C153H225N43O49S Glucagone HSQGTFTSDYSKYLDSRRAQDFVQWLMNT MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon glucagonum CHEBI:5391 Glucagon glucagon CHEBI:5391 CHEBI:58961 Biologically active derivative of anandamide Beilstein:7652004 CiteXplore:21359215 HMDB:HMDB05096 SUBMITTER:LMFA08020003 N-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]glycine N-Arachidonoylglycine chebi_ontology 2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamido]acetic acid InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15- C22H35NO3 CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCC(O)=O N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycine N-Arachidonyl-L-glycine N-Arachidonylglycine N-arachidonoyl glycine NAGly YLEARPUNMCCKMP-DOFZRALJSA-N CHEBI:58961 N-arachidonoylglycine CHEBI:58961 A phosphatidic acid in which the phosphatidyl acyl groups are both oleoyl. Beilstein:1917928 CAS:14268-17-8 LIPID_MAPS_instance:LMGP10010031 PMID:1602135 3-(phosphonooxy)propane-1,2-diyl (9Z,9'Z)bis-octadec-9-enoate chebi_ontology 0 1,2-Dioleoyl-sn-glycero-3-phosphate 1,2-dioleoylglycerol-3-phosphate 700.504 700.96590 C39H73O8P CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC DOPA Dioleoylphosphatidic acid InChI=1S/C39H73O8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,37H,3-16,21-36H2,1-2H3,(H2,42,43,44)/b19-17-,20-18- MHUWZNTUIIFHAS-CLFAGFIQSA-N PA(18:1(9Z)/18:1(9Z))[U] PA(18:1/18:1)[U] CHEBI:60427 dioleoyl phosphatidic acid CHEBI:60427 CHEBI:6102 CAS:342-10-9 KEGG:C01505 Kallidin chebi_ontology 0 1187.656 1188.383 C56H85N17O12 FYSKZKQBTVLYEQ-FSLKYBNLSA-N InChI=1S/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 Lysyl-bradykinin Lysylbradykinin NCCCC[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O CHEBI:6102 Kallidin CHEBI:6102 CHEBI:63977 A trienoic fatty acid that consists of (5Z,8E,10E)-heptadeca-5,8,10-trienoic acid bearing an additional 12S-hydroxy substituent. CiteXplore:20671299 HMDB:HMDB12535 KEGG COMPOUND:54397-84-1 LIPID MAPS:LMFA03050002 MetaCyc:1-KETO-2-METHYLVALERATE Reaxys:8340574 (5Z,8E,10E,12S)-12-hydroxyheptadeca-5,8,10-trienoic acid chebi_ontology 12(S)-Hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoate 12(S)-Hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoic acid 12(S)-Hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoic acid anion InChI=1S/C17H28O3/c1-2-3-10-13-16(18)14-11-8-6-4-5-7-9-12-15-17(19)20/h5-8,11,14,16,18H,2-4,9-10,12-13,15H2,1H3,(H,19,20)/b7-5-,8-6+,14-11+/t16-/m0/s1 12-HHTrE 12-Hydroxyheptadecatrienoate 12-Hydroxyheptadecatrienoic acid 12S-HHT 12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid C17H28O3 CCCCC[C@H](O)\C=C\C=C\C\C=C/CCCC(O)=O HHT Hydroxyheptadecatrienate Hydroxyheptadecatrienoate Hydroxyheptadecatrienoic acid Hydroxyheptadecatrienoic acid anion KUKJHGXXZWHSBG-WBGSEQOASA-N CHEBI:63977 12-hydroxyheptadecatrienoic acid 12S-HHTrE CHEBI:63977 CHEBI:6498 A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds. CiteXplore:12920210 CiteXplore:15320881 CiteXplore:16005201 CiteXplore:16141446 CiteXplore:16550298 CiteXplore:16613568 CiteXplore:1910866 CiteXplore:20435922 CiteXplore:20802423 CiteXplore:20833483 CiteXplore:20950211 CiteXplore:20959513 CiteXplore:21263017 CiteXplore:21359215 CiteXplore:2713393 CiteXplore:8422907 CiteXplore:8690917 HMDB:HMDB04385 KEGG COMPOUND:89663-86-5 KEGG COMPOUND:C06314 LIPID MAPS:LMFA03040001 Reaxys:4698639 (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid Lipoxin A4 lipoxin A4 chebi_ontology (5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyeicosa-7,9,11,13-tetraenoic acid (7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoate (7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoic acid 5(S),6(R),15(S)-trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid 5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoate 5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid 5S,6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1 5S,6R-LipoxinA4 5S,6S-Lipoxin A4 6R-LXA4 C20H32O5 IXAQOQZEOGMIQS-SSQFXEBMSA-N LXA4 CHEBI:6498 LXA4 lipoxin A4 CHEBI:6498 CHEBI:65312 A corticotropin-releasing hormone from human/rat composed of Ser, Glu, Glu, Pro, Pro, Ile, Ser, Leu, Asp, Leu, Val, Phe, His, Leu, Leu, Arg, Glu, Val, Leu, Glu, Met, Ala, Arg, Ala, Glu, Gln, Leu, Ala, Gln, Gln, Ala, His, Ser, Asn, Arg, Lys, Leu, Met, Glu, Ile and Ile-NH2 residues joined in sequence. KEGG:C16079 PMID:21883143 PMID:21959975 PMID:22000570 PMID:22137972 PMID:22198557 PMID:22386641 PMID:22494987 PMID:22533365 PMID:22698524 PMID:22703673 PMID:22734038 PMID:22735860 PMID:22763913 Reaxys:10331364 Wikipedia:Corticotropin-releasing_hormone L-seryl-L-alpha-glutamyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-isoleucyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-valyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-alpha-glutamyl-L-valyl-L-leucyl-L-alpha-glutamyl-L-methionyl-L-alanyl-L-arginyl-L-alanyl-L-alpha-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-L-leucyl-L-methionyl-L-alpha-glutamyl-L-isoleucyl-L-isoleucinamide chebi_ontology 0 4752.521 4755.47800 C209H346N60O62S2 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)C)C(C)C)[C@@H](C)CC)C(N)=O CRH Corticoliberin Corticotropin releasing hormone InChI=1S/C209H346N60O62S2/c1-31-108(22)163(166(216)291)265-204(329)165(110(24)33-3)266-185(310)130(59-68-158(285)286)244-183(308)132(71-79-333-30)247-188(313)135(81-100(6)7)251-177(302)119(46-37-38-72-210)238-175(300)121(48-40-74-226-208(219)220)240-195(320)144(90-153(215)276)257-198(323)146(95-271)261-194(319)142(88-116-92-223-97-228-116)249-170(295)114(28)231-173(298)123(52-61-150(212)273)241-178(303)124(53-62-151(213)274)235-169(294)113(27)233-186(311)134(80-99(4)5)250-182(307)125(54-63-152(214)275)242-179(304)126(55-64-154(277)278)236-168(293)112(26)230-172(297)120(47-39-73-225-207(217)218)234-167(292)111(25)232-174(299)131(70-78-332-29)246-180(305)128(57-66-156(281)282)245-189(314)139(85-104(14)15)259-201(326)161(106(18)19)263-184(309)129(58-67-157(283)284)243-176(301)122(49-41-75-227-209(221)222)239-187(312)136(82-101(8)9)252-190(315)137(83-102(10)11)253-193(318)143(89-117-93-224-98-229-117)256-192(317)141(87-115-44-35-34-36-45-115)260-202(327)162(107(20)21)264-197(322)140(86-105(16)17)254-196(321)145(91-160(289)290)258-191(316)138(84-103(12)13)255-199(324)147(96-272)262-203(328)164(109(23)32-2)267-200(325)148-50-42-76-268(148)206(331)149-51-43-77-269(149)205(330)133(60-69-159(287)288)248-181(306)127(56-65-155(279)280)237-171(296)118(211)94-270/h34-36,44-45,92-93,97-114,118-149,161-165,270-272H,31-33,37-43,46-91,94-96,210-211H2,1-30H3,(H2,212,273)(H2,213,274)(H2,214,275)(H2,215,276)(H2,216,291)(H,223,228)(H,224,229)(H,230,297)(H,231,298)(H,232,299)(H,233,311)(H,234,292)(H,235,294)(H,236,293)(H,237,296)(H,238,300)(H,239,312)(H,240,320)(H,241,303)(H,242,304)(H,243,301)(H,244,308)(H,245,314)(H,246,305)(H,247,313)(H,248,306)(H,249,295)(H,250,307)(H,251,302)(H,252,315)(H,253,318)(H,254,321)(H,255,324)(H,256,317)(H,257,323)(H,258,316)(H,259,326)(H,260,327)(H,261,319)(H,262,328)(H,263,309)(H,264,322)(H,265,329)(H,266,310)(H,267,325)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H4,217,218,225)(H4,219,220,226)(H4,221,222,227)/t108-,109-,110-,111-,112-,113-,114-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,161-,162-,163-,164-,165-/m0/s1 KLVRDXBAMSPYKH-RKYZNNDCSA-N SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2 Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2 corticotropin-releasing factor (human) corticotropin-releasing factor (human/rat) human/rat CRF CHEBI:65312 corticotropin-releasing hormone (human) CHEBI:65312 CHEBI:6603 CAS:50-57-7 KEGG:C07105 KEGG:D00366 Lypressin chebi_ontology 0 1055.432 1056.222 8-L-Lysine vasopressin BJFIDCADFRDPIO-UHFFFAOYSA-N C46H65N13O12S2 DIAPID (TN) InChI=1S/C46H65N13O12S2/c47-17-5-4-9-29(40(65)52-22-38(51)63)54-45(70)35-10-6-18-59(35)46(71)34-24-73-72-23-28(48)39(64)55-31(20-26-11-13-27(60)14-12-26)43(68)56-32(19-25-7-2-1-3-8-25)42(67)53-30(15-16-36(49)61)41(66)57-33(21-37(50)62)44(69)58-34/h1-3,7-8,11-14,28-35,60H,4-6,9-10,15-24,47-48H2,(H2,49,61)(H2,50,62)(H2,51,63)(H,52,65)(H,53,67)(H,54,70)(H,55,64)(H,56,68)(H,57,66)(H,58,69) LVP NCCCCC(NC(=O)C1CCCN1C(=O)C1CSSCC(N)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(Cc2ccccc2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N1)C(=O)NCC(N)=O CHEBI:6603 Lypressin CHEBI:6603 CHEBI:67119 A UDP-D-galactose in which the anomeric centre of the galactose moiety has alpha-configuration. ChemIDplus:2956-16-3 KEGG COMPOUND:2956-16-3 KEGG COMPOUND:C00052 KEGG GLYCAN:G10609 KNApSAcK:C00007390 PDBeChem:GDU Reaxys:102009 uridine 5'-[3-(alpha-D-galactopyranosyl) dihydrogen diphosphate] chebi_ontology InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8+,9-,10+,11-,12-,13-,14-/m1/s1 OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@H]1O C15H24N2O17P2 HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-D-galactopyranose UDP-alpha-D-galactopyranose UDP-galactose Udp galactose Uridine diphosphate galactose Uridine diphosphogalactose Uridine pyrophosphogalactose Uridinediphosphogalactose CHEBI:67119 UDP-alpha-D-galactose UDP-galactose CHEBI:67119 CHEBI:72795 A leukotriene that is the 12S-isomer of leukotriene B4. CAS:83709-73-3 HMDB:HMDB05089 LIPID_MAPS_instance:LMFA03020015 Reaxys:4696045 (5S,6Z,8E,10E,12S,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid chebi_ontology 0 12(S)-Leukotriene B4 12-epi-LTB4 12S-LTB4 336.230 336.46570 5S,12S-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid C20H32O4 CCCCC\C=C/C[C@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19+/m0/s1 VNYSSYRCGWBHLG-CBBLYLIKSA-N CHEBI:72795 12-epi-leukotriene B4 CHEBI:72795 CHEBI:73688 A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage. CAS:3106-85-2 KEGG:C12270 Wikipedia:N-Acetylaspartylglutamic_acid N-acetyl-L-alpha-aspartyl-L-glutamic acid chebi_ontology 0 304.091 304.25330 C11H16N2O8 CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1 N-Ac-D-E N-Acetyl-1-aspartylglutamic acid N-acetyl-L-Asp-L-Glu NAAG OPVPGKGADVGKTG-BQBZGAKWSA-N isospaglumic acid CHEBI:73688 Ac-Asp-Glu CHEBI:73688 CHEBI:7542 A polypeptide that has formula C78H121N21O20. ChemIDplus:39379-15-2 KEGG COMPOUND:39379-15-2 KEGG COMPOUND:55508-42-4 KEGG COMPOUND:C01836 5-oxo-L-prolyl-L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-asparaginyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH Neurotensin chebi_ontology CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(C)C)NC(=O)C1CCC(=O)N1)C(=O)NC(CC(C)C)C(O)=O InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86) C78H121N21O20 PCJGZPGTCUMMOT-UHFFFAOYSA-N CHEBI:7542 Neurotensin neurotensin CHEBI:7542 CHEBI:75431 A 28-membered appetite-stimulating polypeptide consisting of Gly, Ser, Ser, Phe, Leu, Ser, Pro, Glu, His, Gln, Arg, Val, Gln, Gln, Arg, Lys, Glu, Ser, Lys, Lys, Pro, Pro, Ala, Lys, Leu, Gln, Pro and Arg residues joined in sequence. ChemIDplus:304853-26-7 CiteXplore:23159561 CiteXplore:23178701 CiteXplore:23278489 CiteXplore:23307791 CiteXplore:23316086 CiteXplore:23317782 CiteXplore:23359315 CiteXplore:23428971 CiteXplore:23481295 CiteXplore:23524619 CiteXplore:23624808 CiteXplore:23631903 CiteXplore:23652386 CiteXplore:23652399 CiteXplore:23652420 CiteXplore:23698230 CiteXplore:23704134 CiteXplore:23778458 CiteXplore:23804489 CiteXplore:23808302 CiteXplore:23843943 CiteXplore:23847595 CiteXplore:23965296 CiteXplore:23982275 CiteXplore:23989358 KEGG COMPOUND:C16025 Reaxys:10148432 Wikipedia:Ghrelin glycyl-L-seryl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-alpha-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine chebi_ontology CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg InChI=1S/C141H235N47O41/c1-73(2)62-92(123(213)175-90(42-48-107(150)196)135(225)185-58-22-37-102(185)132(222)176-91(138(228)229)34-21-57-160-141(155)156)177-116(206)79(28-11-15-51-142)164-112(202)76(7)162-130(220)100-35-24-60-187(100)137(227)103-38-25-61-188(103)134(224)89(31-14-18-54-145)174-115(205)81(30-13-17-53-144)168-128(218)97(69-190)181-121(211)87(43-49-109(198)199)170-113(203)80(29-12-16-52-143)165-114(204)82(32-19-55-158-139(151)152)166-117(207)84(39-45-104(147)193)169-119(209)86(41-47-106(149)195)173-133(223)111(75(5)6)184-122(212)83(33-20-56-159-140(153)154)167-118(208)85(40-46-105(148)194)171-126(216)95(65-78-67-157-72-161-78)180-120(210)88(44-50-110(200)201)172-131(221)101-36-23-59-186(101)136(226)99(71-192)183-124(214)93(63-74(3)4)178-125(215)94(64-77-26-9-8-10-27-77)179-129(219)98(70-191)182-127(217)96(68-189)163-108(197)66-146/h8-10,26-27,67,72-76,79-103,111,189-192H,11-25,28-66,68-71,142-146H2,1-7H3,(H2,147,193)(H2,148,194)(H2,149,195)(H2,150,196)(H,157,161)(H,162,220)(H,163,197)(H,164,202)(H,165,204)(H,166,207)(H,167,208)(H,168,218)(H,169,209)(H,170,203)(H,171,216)(H,172,221)(H,173,223)(H,174,205)(H,175,213)(H,176,222)(H,177,206)(H,178,215)(H,179,219)(H,180,210)(H,181,211)(H,182,217)(H,183,214)(H,184,212)(H,198,199)(H,200,201)(H,228,229)(H4,151,152,158)(H4,153,154,159)(H4,155,156,160)/t76-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,111-/m0/s1 BGHSOEHUOOAYMY-JTZMCQEISA-N C141H235N47O41 GSSFLSPEHQRVQQRKESKKPPAKLQPR Gastric MLTRP Ghrelin (human) Human ghrelin Motilin-related peptide CHEBI:75431 Ghrelin ghrelin CHEBI:75431 CHEBI:75441 One of the primary forms of gastrin that is a 17-membered peptide consisting of Glp, Gly, Pro, Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe-NH2 residues joined in sequence. ChemIDplus:60748-06-3 CiteXplore:21030667 CiteXplore:21175799 CiteXplore:21389862 CiteXplore:22037174 CiteXplore:22138052 CiteXplore:22696910 CiteXplore:22784345 CiteXplore:23117263 CiteXplore:23311704 CiteXplore:23349211 CiteXplore:23658576 CiteXplore:23886209 CiteXplore:23930120 KEGG COMPOUND:60748-06-3 KEGG COMPOUND:C16113 Patent:CA2698980 Patent:WO2009033729 Patent:WO2009039995 Reaxys:11842134 Reaxys:8188172 Wikipedia:Little_gastrin 5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide chebi_ontology CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 InChI=1S/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-/m0/s1 C97H124N20O31S G 17 GKDWRERMBNGKCZ-RNXBIMIWSA-N Gastrin heptadecapeptide Heptadecapeptide gastrin Little gastrin Little gastrin I CHEBI:75441 Gastrin-17 gastrin-17 CHEBI:75441 CHEBI:7872 A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour. Beilstein:3586108 CAS:50-56-6 DrugBank:DB00107 Drug_Central:2042 HMDB:HMDB02865 KEGG:C00746 KEGG:D00089 PMID:11134819 PMID:13305558 PMID:15815422 PMID:18593851 PMID:18988842 PMID:19104313 PMID:19369205 PMID:19482229 PMID:24706799 PMID:25209411 Patent:US2938891 Patent:US3076797 Wikipedia:Oxytocin 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide Oxytocin chebi_ontology (1-Hemicystine)oxytocin 0 1006.436 1007.18982 3-Isoleucine-8-leucine vasopressin C43H66N12O12S2 Endopituitrina InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1 L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide OT OXT Ocytocin Orasthin Pitocin Piton S Syntocinon XNOPRXBHLZRZKH-DSZYJQQASA-N [H][C@]1(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)[C@@H](C)CC oxitocina oxytocin oxytocine oxytocinum CHEBI:7872 oxytocin CHEBI:7872 CHEBI:80127 CAS:12676-15-2 KEGG:C15849 chebi_ontology Angiotensin II, 1-des-asn-2-arg CHEBI:80127 Angiotensin IV CHEBI:80127 CHEBI:80131 KEGG:C15855 chebi_ontology CHEBI:80131 Apelin-13 CHEBI:80131 CHEBI:80132 KEGG:C15856 chebi_ontology CHEBI:80132 Apelin-36 CHEBI:80132 CHEBI:80139 KEGG:C15865 chebi_ontology NMB CHEBI:80139 Neuromedin B CHEBI:80139 CHEBI:80156 KEGG:C15890 chebi_ontology CHEBI:80156 Endomorphin-1 CHEBI:80156 CHEBI:80161 KEGG COMPOUND:C15901 chebi_ontology CHEBI:80161 Galanin CHEBI:80161 CHEBI:80201 KEGG COMPOUND:C15949 chebi_ontology CHEBI:80201 Neuropeptide Y CHEBI:80201 CHEBI:80238 KEGG:C16008 chebi_ontology 0 1259.677 1260.44350 C59H89N17O14 CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O GKCWYHPGFSRBQV-WRBAKOPXSA-N Ile-Ser-bradykinin InChI=1S/C59H89N17O14/c1-3-34(2)47(60)53(85)72-41(32-77)50(82)69-37(19-10-24-65-58(61)62)54(86)76-28-14-23-45(76)56(88)75-27-12-21-43(75)51(83)67-31-46(79)68-39(29-35-15-6-4-7-16-35)48(80)73-42(33-78)55(87)74-26-13-22-44(74)52(84)71-40(30-36-17-8-5-9-18-36)49(81)70-38(57(89)90)20-11-25-66-59(63)64/h4-9,15-18,34,37-45,47,77-78H,3,10-14,19-33,60H2,1-2H3,(H,67,83)(H,68,79)(H,69,82)(H,70,81)(H,71,84)(H,72,85)(H,73,80)(H,89,90)(H4,61,62,65)(H4,63,64,66)/t34-,37-,38-,39-,40-,41-,42-,43-,44-,45-,47-/m0/s1 CHEBI:80238 T-kinin CHEBI:80238 CHEBI:80240 KEGG COMPOUND:123626-67-5 KEGG COMPOUND:C16010 chebi_ontology CHEBI:80240 Endothelin-1 CHEBI:80240 CHEBI:80242 KEGG:C16012 chebi_ontology CHEBI:80242 Endothelin-2 CHEBI:80242 CHEBI:80243 KEGG COMPOUND:125692-40-2 KEGG COMPOUND:C16013 chebi_ontology CHEBI:80243 Endothelin-3 CHEBI:80243 CHEBI:80244 KEGG:C16016 chebi_ontology CHEBI:80244 Urotensin II CHEBI:80244 CHEBI:80254 KEGG COMPOUND:67382-96-1 KEGG COMPOUND:C16030 chebi_ontology MCH CHEBI:80254 Melanin-concentrating hormone CHEBI:80254 CHEBI:80256 KEGG:C16032 chebi_ontology CHEBI:80256 Neuropeptide W-30 CHEBI:80256 CHEBI:80257 KEGG:C16033 chebi_ontology CHEBI:80257 Neuropeptide W-23 CHEBI:80257 CHEBI:80258 KEGG:C16034 chebi_ontology CHEBI:80258 Neuropeptide B-29 CHEBI:80258 CHEBI:80259 KEGG COMPOUND:C16035 chebi_ontology CHEBI:80259 Neuropeptide B-23 CHEBI:80259 CHEBI:80261 KEGG COMPOUND:C16039 chebi_ontology CHEBI:80261 Alpha-Neoendorphin alpha-Neoendorphin CHEBI:80261 CHEBI:80262 KEGG:C16040 chebi_ontology CHEBI:80262 beta-Neoendorphin CHEBI:80262 CHEBI:80263 KEGG:C16041 chebi_ontology CHEBI:80263 Leu-enkephalin CHEBI:80263 CHEBI:80266 A seventenn-membered polypeptide consisting of Phe, Gly, Gly, Phe, Thr, Gly, Ala, Arg, Lys, Ser, Ala, Arg, Lys, Leu, Ala, Asn and Gln residue joined in sequence. CAS:170713-75-4 KEGG:C16044 PMID:25677778 PMID:25724763 Reaxys:24158864 Reaxys:9753661 L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-alanyl-L-asparaginyl-L-glutamine chebi_ontology 0 1807.981 1809.040 C([C@@H](N)CC=1C=CC=CC1)(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(N[C@H](C(=O)N[C@H](C(N[C@H](C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)N)CC(=O)N)C)=O)CC(C)C)=O)CCCCN)CCCNC(=N)N)=O)C)CO)CCCCN)CCCNC(=N)N)C)[C@@H](C)O)CC=2C=CC=CC2 C79H129N27O22 FGGFTGARKSARKLANQ InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1 L-Phe-Gly-Gly-L-Phe-L-Thr-Gly-L-Ala-L-Arg-L-Lys-L-Ser-L-Ala-L-Arg-L-Lys-L-Leu-L-Ala-L-Asn-L-Gln Nociceptin (1-17) Orphanin FQ PULGYDLMFSFVBL-SMFNREODSA-N Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln PheGlyGlyPheThrGlyAlaArgLysSerAlaArgLysLeuAlaAsnGln CHEBI:80266 nociceptin CHEBI:80266 CHEBI:80269 KEGG COMPOUND:C16047 chebi_ontology CHEBI:80269 Motilin CHEBI:80269 CHEBI:80271 KEGG COMPOUND:C16049 chebi_ontology GLP-2 CHEBI:80271 Glucagon-like peptide 2 CHEBI:80271 CHEBI:80274 KEGG:C16052 chebi_ontology PTHrP (1-36) CHEBI:80274 Parathyroid hormone-related peptide (1-36) CHEBI:80274 CHEBI:80275 KEGG:C16053 chebi_ontology TIP39 CHEBI:80275 Tuberoinfundibular peptide of 39 residues CHEBI:80275 CHEBI:80290 KEGG:C16068 chebi_ontology CHEBI:80290 Humanin CHEBI:80290 CHEBI:80295 KEGG:C16080 chebi_ontology CHEBI:80295 Urocortin I CHEBI:80295 CHEBI:80296 KEGG:C16081 chebi_ontology CHEBI:80296 Urocortin II CHEBI:80296 CHEBI:80297 KEGG:C16082 chebi_ontology CHEBI:80297 Urocortin III CHEBI:80297 CHEBI:80298 KEGG:C16084 chebi_ontology GnRH-II Gonadoliberin-II CHEBI:80298 Gonadotropin-releasing hormone II CHEBI:80298 CHEBI:80302 KEGG:C16088 chebi_ontology PACAP-38 CHEBI:80302 Pituitary adenylate cyclase-activating peptide-38 CHEBI:80302 CHEBI:80303 KEGG:C16089 chebi_ontology PACAP-27 CHEBI:80303 Pituitary adenylate cyclase-activating peptide-27 CHEBI:80303 CHEBI:80305 KEGG:C16091 chebi_ontology CHEBI:80305 Kisspeptin-14 CHEBI:80305 CHEBI:80306 KEGG:C16092 chebi_ontology CHEBI:80306 Kisspeptin-13 CHEBI:80306 CHEBI:80307 KEGG COMPOUND:C16093 chebi_ontology CHEBI:80307 Kisspeptin-10 CHEBI:80307 CHEBI:80308 KEGG:C16094 chebi_ontology CHEBI:80308 Substance P CHEBI:80308 CHEBI:80309 KEGG:C16095 chebi_ontology CHEBI:80309 Neuropeptide K CHEBI:80309 CHEBI:80310 KEGG:C16096 chebi_ontology CHEBI:80310 Neuropeptide gamma CHEBI:80310 CHEBI:80311 A polypeptide that has formula C50H80N14O14S. KEGG COMPOUND:C16097 chebi_ontology CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)O)C(C)C)C(N)=O InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28?,31-,32-,33-,34-,35-,36-,37-,40-,41-/m0/s1 C50H80N14O14S HEAUFJZALFKPBA-YRVBCFNBSA-N Neuromedin L Substance K CHEBI:80311 Neurokinin A CHEBI:80311 CHEBI:80312 KEGG:C16098 chebi_ontology 0 1209.531 1210.42400 C55H79N13O14S2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(N)=O InChI=1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1 NHXYSAFTNPANFK-HDMCBQFHSA-N Neuromedin K Tachykinin-3 CHEBI:80312 Neurokinin B CHEBI:80312 CHEBI:80319 CAS:205599-75-3 KEGG:C16105 chebi_ontology CHEBI:80319 Orexin A CHEBI:80319 CHEBI:80320 CAS:205599-76-4 KEGG:C16106 chebi_ontology CHEBI:80320 Orexin B CHEBI:80320 CHEBI:80324 KEGG:C16110 chebi_ontology RFRP-3 CHEBI:80324 RFamide-related peptide 3 CHEBI:80324 CHEBI:80326 KEGG COMPOUND:C16112 chebi_ontology CHEBI:80326 Neuropeptide FF CHEBI:80326 CHEBI:80327 KEGG:C16114 chebi_ontology CCK-8 CHEBI:80327 Cholecystokinin-8 CHEBI:80327 CHEBI:80328 KEGG COMPOUND:C16115 chebi_ontology GRP CHEBI:80328 Gastrin-releasing peptide CHEBI:80328 CHEBI:80329 KEGG:C16117 chebi_ontology CHEBI:80329 Pancreatic polypeptide CHEBI:80329 CHEBI:80330 KEGG:C16118 chebi_ontology CHEBI:80330 Peptide YY CHEBI:80330 CHEBI:80331 CAS:37221-79-7 KEGG:C16119 chebi_ontology VIP CHEBI:80331 Vasoactive intestinal peptide CHEBI:80331 CHEBI:80336 KEGG:C16124 chebi_ontology INSL 3 Relaxin-like factor CHEBI:80336 Insulin-like 3 CHEBI:80336 CHEBI:80337 KEGG:C16125 chebi_ontology Calcitonin-related polypeptide alpha alpha-CGRP CHEBI:80337 Calcitonin gene-related peptide 1 CHEBI:80337 CHEBI:80338 KEGG:C16126 chebi_ontology Calcitonin-related polypeptide beta beta-CGRP CHEBI:80338 Calcitonin gene-related peptide 2 CHEBI:80338 CHEBI:80339 KEGG COMPOUND:148498-78-6 KEGG COMPOUND:C16127 chebi_ontology CHEBI:80339 Adrenomedullin CHEBI:80339 CHEBI:80340 KEGG:C16128 chebi_ontology CHEBI:80340 Adrenomedullin 2 CHEBI:80340 CHEBI:80342 KEGG:C16130 chebi_ontology Islet amyloid polypeptide CHEBI:80342 Amylin CHEBI:80342 CHEBI:80345 KEGG:C16133 chebi_ontology CCK-33 CHEBI:80345 Cholecystokinin-33 CHEBI:80345 CHEBI:80347 CAS:83335-41-5 KEGG:C16135 chebi_ontology Rimorphin CHEBI:80347 Dynorphin B CHEBI:80347 CHEBI:80349 KEGG:C16137 chebi_ontology gamma-MSH gamma-Melanocyte-stimulating hormone CHEBI:80349 gamma-Melanotropin CHEBI:80349 CHEBI:81559 A resolvin that is (6Z,8E,10E,14Z,16E)-icosa-6,8,10,14,16-pentaenoic acid which is substituted at positions 5, 12 and 18 by hydroxy groups (the 5S,12R,18R stereoisomer). HMDB:HMDB10410 KEGG:C18171 LIPID_MAPS_instance:LMFA03070019 MetaCyc:CPD66-57 PMID:15753205 PMID:16112645 PMID:16373400 PMID:16757471 PMID:17131464 PMID:17339491 PMID:17982093 PMID:18190790 PMID:18292578 PMID:18480426 PMID:19368495 PMID:20119897 PMID:20708601 PMID:22257864 PMID:22297737 PMID:22336459 PMID:22951188 PMID:24344649 PMID:25637017 PMID:25681756 PMID:25792445 PMID:26438363 Reaxys:11884203 (5S,6Z,8E,10E,12R,14Z,16E,18R)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid chebi_ontology (5S,12R,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoic acid (5S,12R,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-icosapentaenoic acid (6Z,8E,10E,14Z,16E)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid 0 350.209 350.450 5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-EPA 5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid AOPOCGPBAIARAV-OTBJXLELSA-N C(\[C@H](CCCC(O)=O)O)=C\C=C\C=C\[C@@H](C\C=C/C=C/[C@@H](CC)O)O C20H30O5 InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)/b4-3+,9-5-,11-8+,12-6+,13-7-/t17-,18+,19-/m1/s1 ResolvinE1 RvE1 CHEBI:81559 resolvin E1 CHEBI:81559 CHEBI:81564 A resolvin that is docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid which is substituted by hydroxy groups at the 7, 8, and 17 positions (the 7S,8R,17S-stereoisomer). HMDB:HMDB03733 KEGG:C18178 LIPID_MAPS_instance:LMFA04000006 MetaCyc:CPD66-64 PMID:17090225 PMID:17244615 PMID:21359215 PMID:26462421 PMID:26531230 PMID:26597784 PMID:26630551 PMID:26702138 PMID:26808633 PMID:26843331 PMID:26878867 PMID:26969756 PMID:27009328 PMID:27056390 PMID:27098797 PMID:27133431 PMID:27145782 Reaxys:20871109 (4Z,7S,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid chebi_ontology 0 376.225 376.487 7S,8,17S-Trihydroxy-docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoate 7S,8,17S-Trihydroxy-docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid 7S,8R,17S-Trihydroxydocosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid C(\CCC(O)=O)=C\C[C@@H]([C@@H](\C=C\C=C\C=C/C=C/[C@H](C/C=C\CC)O)O)O C22H32O5 InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20+,21-/m0/s1 OIWTWACQMDFHJG-CCFUIAGSSA-N RvD1 CHEBI:81564 resolvin D1 CHEBI:81564 CHEBI:81568 CAS:9002-67-9 KEGG:C18183 chebi_ontology ICSH Interstitial cell stimulating hormone LH CHEBI:81568 Luteinizing hormone CHEBI:81568 CHEBI:81664 KEGG:C18313 chebi_ontology CHEBI:81664 LL-37 CHEBI:81664 CHEBI:89666 CAS:12687-51-3 HMDB:HMDB01036 PMID:10778144 PMID:11295571 PMID:11751722 PMID:12428219 PMID:12584663 PMID:12609766 PMID:14996614 PMID:15529593 PMID:15748538 PMID:15894523 PMID:16149578 PMID:16842210 PMID:17094048 PMID:17210474 PMID:190880 PMID:2197067 PMID:3284361 PMID:3893156 PMID:6088844 PMID:6183092 PMID:6316802 PMID:6324655 PMID:7850406 PMID:8170622 PMID:8574286 PMID:8923799 PMID:9370053 PMID:9537002 PMID:9655649 PMID:9857379 Wikipedia:Angiotensin_III (2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid chebi_ontology 0 930.508 931.093 C46H66N12O9 Des-Asp-1-Angiotensin II InChI=1S/C46H66N12O9/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51)/t27-,32-,33-,34-,35-,36-,37-,38-/m0/s1 O=C(N1[C@@H](CCC1)C(=O)N[C@@H](CC2=CC=CC=C2)C(O)=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)CC3=CC=C(O)C=C3)[C@H](CC)C)CC=4NC=NC4 QMMRCKSBBNJCMR-KMZPNFOHSA-N CHEBI:89666 Angiotensin III CHEBI:89666 CHEBI:9574 KEGG COMPOUND:9002-04-4 KEGG COMPOUND:C00752 KEGG DRUG:D00090 Thrombin chebi_ontology CHEBI:9574 Thrombin CHEBI:9574 CHEBI:9937 A family of cyclic nonapeptide hormones found in most mammals. Synthesised in the hypothalamus and stored in the post-pituitary, vasopressins play a key role in homeostasis, particularly in regulating the body's water content. Together with the similar neuropeptide oxytocin, they are believed to influence social cognition and behaviour. CAS:11000-17-2 KEGG:C00840 KEGG:D00101 PMID:18988842 PMID:20445498 Vasopressin chebi_ontology ADH AVP Antidiuretic hormone C46H65N15O12S2.C46H65N13O12S2 Inyectable de vasopresina Solute injectable de vasopressine VP Vasopressini injectio arginine vasopressin argipressin beta-Hypophamine CHEBI:9937 vasopressin CHEBI:9937 DOID:0001816 A malignant Vascular tumor that results_in rapidly proliferating, extensively infiltrating anaplastic cells derives_from blood vessels and derived_from the lining of irregular blood-filled spaces. DOID:267 DOID:4508 MESH:D006394 NCI:C3088 NCI:C9275 SNOMEDCT_US_2016_03_01:33176006 SNOMEDCT_US_2016_03_01:39000009 SNOMEDCT_US_2016_03_01:403977003 UMLS_CUI:C0018923 UMLS_CUI:C0854893 hemangiosarcoma disease_ontology DOID:0001816 angiosarcoma DOID:0002116 laronhughes 2010-06-30T02:44:30Z ICD10CM:H11.0 ICD10CM:H11.00 ICD10CM:H11.009 ICD9CM:372.4 ICD9CM:372.40 MESH:D011625 SNOMEDCT_US_2016_03_01:155165000 SNOMEDCT_US_2016_03_01:193879003 SNOMEDCT_US_2016_03_01:193884009 SNOMEDCT_US_2016_03_01:77489003 UMLS_CUI:C0033999 surfer's eye disease_ontology DOID:0002116 pterygium DOID:0014667 A disease that involving errors in metabolic processes of building or degradation of molecules. ICD10CM:E88.9 ICD9CM:277.9 MESH:D008659 NCI:C3235 SNOMEDCT_US_2016_03_01:154733004 SNOMEDCT_US_2016_03_01:190961002 SNOMEDCT_US_2016_03_01:267456000 SNOMEDCT_US_2016_03_01:30390004 SNOMEDCT_US_2016_03_01:75934005 UMLS_CUI:C0025517 metabolic disease disease_ontology DOID:0014667 disease of metabolism DOID:0050012 A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash. Chikungunya fever disease_ontology DOID:0050012 chikungunya DOID:0050013 An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism. disease_ontology DOID:0050013 carbohydrate metabolism disease DOID:0050025 An ehrlichiosis that results_in infection located_in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted_by lone start tick (Amblyomma americanum ). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash. DOID:0050021 DOID:0050022 human granulocytic ehrlichiosis disease_ontology HGE DOID:0050025 human granulocytic anaplasmosis DOID:0050026 An ehrlichiosis that results_in infection located_in monocyte or located_in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash. DOID:14091 disease_ontology Ehrlichiosis chafeensis DOID:0050026 human monocytic ehrlichiosis DOID:0050032 An acquired metabolic disease that is characterized by abnormal mineral metabolism. disease_ontology DOID:0050032 mineral metabolism disease DOID:0050035 A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash. DOID:0050034 DOID:0050036 Rickettsia africae spotted fever south african tick-bite fever disease_ontology DOID:0050035 African tick-bite fever DOID:0050043 A spotted fever that has_material_basis_in Rickettsia conorii subsp israelensis, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities. disease_ontology Israeli spotted fever DOID:0050043 Israeli tick typhus DOID:0050073 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage. disease_ontology DOID:0050073 invasive aspergillosis DOID:0050083 disease_ontology DOID:0050083 Keshan disease DOID:0050096 A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules. dermatophytosis of beard disease_ontology DOID:0050096 tinea barbae DOID:0050117 A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. DOID:10115 DOID:11078 DOID:1304 DOID:1321 DOID:2040 DOID:2288 DOID:3099 DOID:4120 DOID:4620 DOID:5256 DOID:945 DOID:95 DOID:9532 DOID:9696 ICD9CM:079.0 UMLS_CUI:C0001485 infectious disease disease_ontology DOID:0050117 disease by infectious agent DOID:0050118 A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis. DOID:10840 ICD10CM:A83.5 ICD9CM:062.5 MESH:D004670 SNOMEDCT_US_2016_03_01:186588007 SNOMEDCT_US_2016_03_01:266103004 SNOMEDCT_US_2016_03_01:416442006 SNOMEDCT_US_2016_03_01:417075004 SNOMEDCT_US_2016_03_01:418531007 SNOMEDCT_US_2016_03_01:69627004 UMLS_CUI:C0014053 California Encephalitis California virus encephalitis Neuroinvasive California encephalitis virus infection disease_ontology DOID:0050118 La Crosse encephalitis DOID:0050127 A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip. DOID:2052 DOID:9564 ICD10CM:J01 ICD10CM:J01.9 ICD10CM:J01.90 ICD9CM:461 ICD9CM:461.9 SNOMEDCT_US_2016_03_01:155498004 SNOMEDCT_US_2016_03_01:155501004 SNOMEDCT_US_2016_03_01:15805002 SNOMEDCT_US_2016_03_01:195649005 SNOMEDCT_US_2016_03_01:195653007 SNOMEDCT_US_2016_03_01:266378004 UMLS_CUI:C0149512 disease_ontology DOID:0050127 sinusitis DOID:0050129 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions. disease_ontology DOID:0050129 secretory diarrhea DOID:0050133 A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host. DOID:13370 ICD10CM:B36.9 MESH:D010854 SNOMEDCT_US_2016_03_01:154408001 SNOMEDCT_US_2016_03_01:187002008 SNOMEDCT_US_2016_03_01:187476003 SNOMEDCT_US_2016_03_01:266218008 SNOMEDCT_US_2016_03_01:276206000 SNOMEDCT_US_2016_03_01:402135006 SNOMEDCT_US_2016_03_01:47382004 UMLS_CUI:C0031898 UMLS_CUI:C2980104 Steroid-modified tinea infection piedra disease_ontology DOID:0050133 Adding a UMLS CUI for piedra C2980104. superficial mycosis DOID:0050134 A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions. disease_ontology DOID:0050134 cutaneous mycosis DOID:0050136 A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs. disease_ontology DOID:0050136 systemic mycosis DOID:0050138 disease_ontology DOID:0050138 podoconiosis DOID:0050148 An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe. DOID:11795 DOID:9390 ICD10CM:J04 ICD10CM:J04.2 ICD10CM:J37.1 ICD9CM:464 ICD9CM:464.2 ICD9CM:476.1 SNOMEDCT_US_2016_03_01:155505008 SNOMEDCT_US_2016_03_01:155508005 SNOMEDCT_US_2016_03_01:195679003 SNOMEDCT_US_2016_03_01:195694004 SNOMEDCT_US_2016_03_01:195697006 SNOMEDCT_US_2016_03_01:195703007 SNOMEDCT_US_2016_03_01:276443001 SNOMEDCT_US_2016_03_01:64375000 SNOMEDCT_US_2016_03_01:83271005 UMLS_CUI:C0155811 UMLS_CUI:C0155837 disease_ontology DOID:0050148 laryngotracheitis DOID:0050152 A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough. ICD10CM:J69.0 MESH:D011015 SNOMEDCT_US_2016_03_01:422588002 SNOMEDCT_US_2016_03_01:47839005 UMLS_CUI:C0032290 disease_ontology DOID:0050152 aspiration pneumonia DOID:0050155 A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell). disease_ontology DOID:0050155 sensory system disease DOID:0050156 An idiopathic interstitial pneumonia which is a distinctive type of chronic fibrosing interstitial pneumonia with thick scarring in the lung creating a honeycomb appearance. The main symptoms start insidiously as shortness of breath on exertion, cough, and diminished stamina. Other common complaints include weight loss and fatigue. The level of oxygen in the blood decreases, and the skin may take on a bluish tinge (called cyanosis) and the ends of the fingers may become thick or club-shape. In most people, symptoms worsen over a period ranging from about 6 months to several years. EFO:0000768 ICD10CM:J84.112 ICD9CM:516.31 MESH:D054990 NCI:C35715 NCI:C35716 OMIM:178500 SNOMEDCT_US_2016_03_01:196125002 SNOMEDCT_US_2016_03_01:233721005 SNOMEDCT_US_2016_03_01:237121003 SNOMEDCT_US_2016_03_01:28168000 SNOMEDCT_US_2016_03_01:426437004 UMLS_CUI:C1800706 FIBROCYSTIC PULMONARY DYSPLASIA IDIOPATHIC PULMONARY FIBROSIS, FAMILIAL cryptogenic fibrosing alveolitis disease_ontology DOID:0050156 OMIM mapping confirmed by DO. [SN]. idiopathic pulmonary fibrosis DOID:0050161 A respiratory system disease which involves the lower respiratory tract. ICD9CM:478.1 ICD9CM:478.19 SNOMEDCT_US_2016_03_01:195823002 SNOMEDCT_US_2016_03_01:266346007 UMLS_CUI:C0029581 disease_ontology DOID:0050161 lower respiratory tract disease DOID:0050167 An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. OMIM:240300 Autoimmune Polyglandular Syndrome I Whitaker syndrom autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy disease_ontology DOID:0050167 autoimmune polyendocrine syndrome type 1 DOID:0050168 An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene. Schmidt syndrome disease_ontology DOID:0050168 autoimmune polyendocrine syndrome type 2 DOID:0050175 A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis. DOID:0050176 DOID:10251 DOID:10252 ICD10CM:A84.1 ICD9CM:063.2 MESH:D004675 SNOMEDCT_US_2016_03_01:16901001 UMLS_CUI:C0014054 Central European encephalitis Far Eastern TBE Russian spring-summer encephalitis Siberian tick-borne encephalitis Taiga encephalitis Western European tick-borne encephalitis west-Siberian encephalitis disease_ontology DOID:0050175 tick-borne encephalitis DOID:0050177 A genetic disease that is the result of one or more abnormal alleles and may be dominant (a single copy of the abnormal allele is sufficient to give rise to the disease), semi-dominant, or recessive (requiring both copies of the gene to have an abnormal allele). disease_ontology DOID:0050177 monogenic disease DOID:0050194 A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations. disease_ontology DOID:0050194 Argentine hemorrhagic fever DOID:0050214 A neuromuscular junction disease that is characterized by an abnormality of acetylcholine (ACh) release at the neuromuscular junction which results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal. ICD10CM:G70.80 ICD9CM:358.3 MESH:D015624 NCI:C3155 SNOMEDCT_US_2016_03_01:230688006 SNOMEDCT_US_2016_03_01:56989000 UMLS_CUI:C0022972 Eaton-Lambert syndrome LEMS Lambert-Eaton syndrome disease_ontology DOID:0050214 Lambert-Eaton myasthenic syndrome DOID:0050268 A myiasis that involves parasitic infestation of Oestrus ovis larvae in the eye causing severe irritation, edema, and pain. disease_ontology DOID:0050268 ophthalmomyiasis DOID:0050292 A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract. disease_ontology DOID:0050292 primary systemic mycosis DOID:0050328 A hypothyroidism that is present at birth. DOID:11631 DOID:11632 ICD10CM:E00.1 ICD10CM:E03.1 ICD9CM:243 MESH:D003409 NCI:C26734 NCI:C98921 OMIM:218700 OMIM:225250 OMIM:274400 OMIM:274500 OMIM:274700 OMIM:274900 OMIM:275100 OMIM:275200 OMIM:607200 OMIM:609893 OMIM:614450 SNOMEDCT_US_2016_03_01:154660000 SNOMEDCT_US_2016_03_01:154661001 SNOMEDCT_US_2016_03_01:190268003 SNOMEDCT_US_2016_03_01:190273009 SNOMEDCT_US_2016_03_01:217710005 SNOMEDCT_US_2016_03_01:267376007 SNOMEDCT_US_2016_03_01:267465007 SNOMEDCT_US_2016_03_01:3614006 SNOMEDCT_US_2016_03_01:75065003 UMLS_CUI:C0010308 UMLS_CUI:C0342200 cretinism disease_ontology DOID:0050328 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital hypothyroidism DOID:0050331 An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes. OMIM:149730 LEVY-HOLLISTER SYNDROME lacrimoauriculodentodigital syndrome disease_ontology DOID:0050331 OMIM mapping confirmed by DO. [SN]. LADD syndrome DOID:0050332 OMIM:600791 disease_ontology DOID:0050332 OMIM mapping confirmed by DO. [SN]. enlarged vestibular aqueduct DOID:0050335 A retinal disease characterized by the slower than usual adaptation of the eyes to changing light conditions; can have material basis in mutations in the RGS9 or the R9AP genes. MESH:C564243 OMIM:608415 ORDO:75374 SNOMEDCT_US_2016_03_01:711163009 UMLS_CUI:C1842073 prolonged electroretinal response suppression disease_ontology DOID:0050335 bradyopsia DOID:0050336 disease_ontology DOID:0050336 hypophosphatemia DOID:0050338 A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread. disease_ontology DOID:0050338 primary bacterial infectious disease DOID:0050339 A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder. disease_ontology DOID:0050339 commensal bacterial infectious disease DOID:0050424 An autosomal dominant disease that is has material basis in mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer. MESH:D011125 NCI:C3339 OMIM:175100 OMIM:608456 SNOMEDCT_US_2016_03_01:154609001 SNOMEDCT_US_2016_03_01:188828009 SNOMEDCT_US_2016_03_01:269636003 SNOMEDCT_US_2016_03_01:423471004 SNOMEDCT_US_2016_03_01:70921007 SNOMEDCT_US_2016_03_01:72900001 UMLS_CUI:C0032580 UMLS_CUI:C2713442 UMLS_CUI:C2713443 adenomatous polyposis of the colon disease_ontology DOID:0050424 OMIM mapping confirmed by DO. [SN]. familial adenomatous polyposis DOID:0050425 A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them. EFO:0004270 ICD10CM:G25.81 ICD9CM:333.94 MESH:D012148 NCI:C84501 OMIM:102300 OMIM:610438 OMIM:610439 OMIM:611185 OMIM:611242 OMIM:612853 OMIM:615197 SNOMEDCT_US_2016_03_01:32914008 SNOMEDCT_US_2016_03_01:393579008 UMLS_CUI:C0035258 WED Willis-Ekbom disease Wittmaack-Ekbom syndrome disease_ontology DOID:0050425 Xref MGI. restless legs syndrome DOID:0050426 EFO:0004276 ICD10CM:L51.1 ICD10CM:L51.2 ICD9CM:695.13 ICD9CM:695.15 MESH:D013262 NCI:C79484 NCI:C79777 SNOMEDCT_US_2016_03_01:156362004 SNOMEDCT_US_2016_03_01:200919006 SNOMEDCT_US_2016_03_01:23067006 SNOMEDCT_US_2016_03_01:238819008 SNOMEDCT_US_2016_03_01:267848009 SNOMEDCT_US_2016_03_01:403609001 SNOMEDCT_US_2016_03_01:73442001 UMLS_CUI:C0014518 UMLS_CUI:C0038325 UMLS_CUI:C1274933 UMLS_CUI:C3658301 UMLS_CUI:C3658302 disease_ontology DOID:0050426 Stevens-Johnson syndrome DOID:0050427 An autosomal recessive disease that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair. ICD10CM:Q82.1 MESH:D014983 NCI:C3452 SNOMEDCT_US_2016_03_01:44600005 UMLS_CUI:C0043346 disease_ontology DOID:0050427 OMIM mapping confirmed by DO. [SN]. xeroderma pigmentosum DOID:0050428 A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles. MESH:D015776 NCI:C3147 OMIM:600962 OMIM:613000 OMIM:615735 ORDO:2337 SNOMEDCT_US_2016_03_01:205584004 SNOMEDCT_US_2016_03_01:28596004 SNOMEDCT_US_2016_03_01:400123002 SNOMEDCT_US_2016_03_01:81206005 UMLS_CUI:C0022584 UMLS_CUI:C3489771 Thost-Unna Syndrome Unna-Thost Syndrome diffuse nonepidermolytic palmomplantar keratoderma tylosis disease_ontology DOID:0050428 Xref MGI. OMIM mapping confirmed by DO. [SN]. nonepidermolytic palmoplantar keratoderma DOID:0050430 An autosomal dominant disease characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis. ICD10CM:E31.22 ICD9CM:258.02 MESH:D018813 NCI:C3226 OMIM:171400 ORDO:247698 SNOMEDCT_US_2016_03_01:61808009 UMLS_CUI:C0025268 MEN2A Sipple syndrome multiple endocrine neoplasia II disease_ontology DOID:0050430 OMIM mapping confirmed by DO. [SN]. multiple endocrine neoplasia type 2A DOID:0050431 An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle. MESH:D019571 NCI:C84571 OMIM:PS107970 ORDO:217656 ORDO:247 SNOMEDCT_US_2016_03_01:253528005 SNOMEDCT_US_2016_03_01:281170005 UMLS_CUI:C0349788 ARVC ARVC cardiomyopathy ARVD arrhythmogenic right ventricular dysplasia arrhythmogenic right ventricular dysplasia/cardiomyopathy disease_ontology DOID:0050431 Xref MGI. OMIM mapping confirmed by DO. [SN]. arrhythmogenic right ventricular cardiomyopathy DOID:0050432 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development. ICD10CM:F84.5 MESH:D020817 NCI:C97159 OMIM:300494 OMIM:300497 OMIM:608631 OMIM:608638 OMIM:608781 OMIM:609954 ORDO:1162 SNOMEDCT_US_2016_03_01:154879004 SNOMEDCT_US_2016_03_01:192586006 SNOMEDCT_US_2016_03_01:23560001 UMLS_CUI:C0236792 disease_ontology DOID:0050432 Xref MGI. OMIM mapping confirmed by DO. [SN]. Asperger syndrome DOID:0050434 A long QT syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly. MESH:D050030 NCI:C84559 OMIM:170390 ORDO:37553 SNOMEDCT_US_2016_03_01:422348008 UMLS_CUI:C1563715 ANDERSEN CARDIODYSRHYTHMIC PERIODIC PARALYSIS ATS Andersen syndrome LQT7 Long QT syndrome 7 Potassium-Sensitive Cardiodysrhythmic Type disease_ontology DOID:0050434 OMIM mapping confirmed by DO. [SN]. Andersen-Tawil syndrome DOID:0050437 MESH:D052120 NCI:C84735 OMIM:300257 SNOMEDCT_US_2016_03_01:419097006 UMLS_CUI:C0878677 ANTOPOL DISEASE PSEUDOGLYCOGENOSIS II disease_ontology DOID:0050437 OMIM mapping confirmed by DO. [SN]. Danon disease DOID:0050439 A syndrome characterized by a combination of hearing loss and visual impairment. MESH:D052245 NCI:C85217 OMIM:PS276900 ORDO:886 SNOMEDCT_US_2016_03_01:57838006 SNOMEDCT_US_2016_03_01:73119000 UMLS_CUI:C0271097 UMLS_CUI:C1568248 UMLS_CUI:C1568249 UMLS_CUI:C2931205 disease_ontology DOID:0050439 Xref MGI. OMIM mapping confirmed by DO. [LS]. Usher syndrome DOID:0050450 MESH:D053579 NCI:C84730 OMIM:263800 SNOMEDCT_US_2016_03_01:3188003 SNOMEDCT_US_2016_03_01:707756004 UMLS_CUI:C0268450 HYPOMAGNESEMIA-HYPOKALEMIA, PRIMARY RENOTUBULAR, WITH HYPOCALCIURIA disease_ontology DOID:0050450 OMIM mapping confirmed by DO. [SN]. Gitelman syndrome DOID:0050451 A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. ICD10CM:I49.8 MESH:D053840 NCI:C71059 SNOMEDCT_US_2016_03_01:418818005 UMLS_CUI:C1142166 UMLS_CUI:C1721096 UMLS_CUI:C1955837 disease_ontology DOID:0050451 OMIM mapping confirmed by DO. [SN]. Brugada syndrome DOID:0050452 MESH:D054078 NCI:C84890 OMIM:610377 SNOMEDCT_US_2016_03_01:124327008 SNOMEDCT_US_2016_03_01:234538002 UMLS_CUI:C0342731 UMLS_CUI:C0398691 UMLS_CUI:C1959626 Mevalonate Kinase Deficiency disease_ontology DOID:0050452 OMIM mapping confirmed by DO. [SN]. mevalonic aciduria DOID:0050453 A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation. ICD10CM:Q04.3 ICD10CM:Q04.8 MESH:D054082 NCI:C103921 OMIM:300067 OMIM:300215 OMIM:607432 OMIM:611603 OMIM:614019 OMIM:615191 ORDO:102009 SNOMEDCT_US_2016_03_01:204036008 SNOMEDCT_US_2016_03_01:23024003 UMLS_CUI:C0266463 UMLS_CUI:C0266483 disease_ontology DOID:0050453 Xref MGI. OMIM mapping confirmed by DO. [SN]. lissencephaly DOID:0050454 A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain. MESH:D054091 OMIM:300049 OMIM:608097 OMIM:608098 OMIM:612881 OMIM:615544 ORDO:98892 SNOMEDCT_US_2016_03_01:448227009 UMLS_CUI:C1848213 UMLS_CUI:C1868720 periventricular heterotopia disease_ontology DOID:0050454 Xref MGI. OMIM mapping confirmed by DO. [SN]. periventricular nodular heterotopia DOID:0050459 MESH:D054559 NCI:C113750 SNOMEDCT_US_2016_03_01:20165001 UMLS_CUI:C0085681 disease_ontology DOID:0050459 hyperphosphatemia DOID:0050460 DOID:6684 ICD10CM:Q93.3 MESH:D054877 NCI:C35528 OMIM:194190 SNOMEDCT_US_2016_03_01:17122004 UMLS_CUI:C0796117 UMLS_CUI:C1956097 4p deletion syndrome PITT SYNDROME Pitt-Rogers-Danks Syndrome chromosome 4p16.3 deletion syndrome disease_ontology DOID:0050460 OMIM mapping confirmed by DO. [LS]. Wolf-Hirschhorn syndrome DOID:0050462 An autosomal recessive disease that is characterized at birth or prenatally by malformations and deformities affecting the majority of the skeleton and other areas of the body with autosomal recessive inheritance of the FGFR2 gene. MESH:D054882 OMIM:201750 OMIM:207410 SNOMEDCT_US_2016_03_01:62964007 UMLS_CUI:C1860042 UMLS_CUI:C2350233 UMLS_CUI:C2936791 trapezoidocephaly-synostosis syndrome disease_ontology DOID:0050462 OMIM mapping confirmed by DO. [SN]. Antley-Bixler syndrome DOID:0050466 MESH:D055947 NCI:C75006 OMIM:609192 OMIM:610168 OMIM:613795 OMIM:614816 ORDO:60030 SNOMEDCT_US_2016_03_01:446263001 UMLS_CUI:C1836635 UMLS_CUI:C2697932 disease_ontology DOID:0050466 Xref MGI. OMIM mapping confirmed by DO. [SN]. Loeys-Dietz syndrome DOID:0050469 A syndrome characterized by craniofacial dysmorphology, cardiac defects, mild mental retardation, and high birth weight followed by a failure to thrive and developmental delays. MESH:D056685 NCI:C84652 OMIM:218040 SNOMEDCT_US_2016_03_01:205803001 SNOMEDCT_US_2016_03_01:309776008 UMLS_CUI:C0587248 FCS SYNDROME Faciocutaneoskeletal Syndrome disease_ontology DOID:0050469 OMIM mapping confirmed by DO. [SN]. Costello syndrome DOID:0050470 MESH:D056731 NCI:C84676 OMIM:246200 SNOMEDCT_US_2016_03_01:111307005 SNOMEDCT_US_2016_03_01:33559001 UMLS_CUI:C0265344 UMLS_CUI:C0271695 Leprechaunism disease_ontology DOID:0050470 OMIM mapping confirmed by DO. [SN]. Donohue syndrome DOID:0050471 An autosomal dominant disease characterized by myxomas, spotty pigmentation of the skin and endocrine overactivity. MESH:D056733 NCI:C4705 OMIM:160980 OMIM:605244 OMIM:608837 ORDO:1359 SNOMEDCT_US_2016_03_01:239132009 UMLS_CUI:C0406810 UMLS_CUI:C1854540 UMLS_CUI:C2607929 Carney Complex, Type 1 Carney Complex, Type 2 Carney Syndrome Carney complex variant LAMB Syndrome NAME Syndrome disease_ontology DOID:0050471 Xref MGI. OMIM mapping confirmed by DO. [SN]. Carney complex DOID:0050472 ICD10CM:Q84.1 MESH:D056734 NCI:C84894 OMIM:158000 SNOMEDCT_US_2016_03_01:205596006 SNOMEDCT_US_2016_03_01:276482004 SNOMEDCT_US_2016_03_01:69488000 UMLS_CUI:C0546966 disease_ontology DOID:0050472 OMIM mapping confirmed by DO. [SN]. monilethrix DOID:0050477 MESH:D056929 NCI:C84827 OMIM:177200 SNOMEDCT_US_2016_03_01:190901004 SNOMEDCT_US_2016_03_01:237493003 SNOMEDCT_US_2016_03_01:707749005 SNOMEDCT_US_2016_03_01:71275003 UMLS_CUI:C0221043 Liddle's syndrome Pseudoaldosteronism disease_ontology DOID:0050477 OMIM mapping confirmed by DO. [SN]. Liddle syndrome DOID:0050481 A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash. DOID:0050028 DOID:0050029 DOID:0050030 DOID:0050057 DOID:0050058 Rat-Flea Typhus Rickettsia felis spotted fever Urban Typhus of Malaya cat flea rickettsiosis fleaborne typhus murine typhus toulon typhus urban typhus disease_ontology Shop typhus DOID:0050481 endemic typhus DOID:0050486 ICD10CM:R21 ICD9CM:782.1 MESH:D005076 NCI:C111884 NCI:C39594 SNOMEDCT_US_2016_03_01:112625008 SNOMEDCT_US_2016_03_01:139684003 SNOMEDCT_US_2016_03_01:158230006 SNOMEDCT_US_2016_03_01:158231005 SNOMEDCT_US_2016_03_01:158234002 SNOMEDCT_US_2016_03_01:1806006 SNOMEDCT_US_2016_03_01:206860008 SNOMEDCT_US_2016_03_01:206861007 SNOMEDCT_US_2016_03_01:206864004 SNOMEDCT_US_2016_03_01:267183006 SNOMEDCT_US_2016_03_01:271807003 UMLS_CUI:C0015230 Rash exanthema disease_ontology DOID:0050486 exanthem DOID:0050515 A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis. disease_ontology DOID:0050515 paralytic poliomyelitis DOID:0050524 A genetic disease that has_material_basis_in mutations in the MODY genes disrupting insulin production. ICD10CM:E11.8 KEGG:04950 OMIM:125850 OMIM:125851 OMIM:137920 OMIM:600496 OMIM:606391 OMIM:606392 OMIM:606394 OMIM:609812 OMIM:610508 OMIM:612225 OMIM:613370 OMIM:613375 OMIM:616329 OMIM:616511 ORDO:552 MODY Mason-type diabetes disease_ontology DOID:0050524 Xref MGI. OMIM mapping confirmed by DO. [SN]. maturity-onset diabetes of the young DOID:0050532 NEVUS, KERATINOCYTIC, NONEPIDERMOLYTIC PIGMENTED MOLES disease_ontology DOID:0050532 OMIM mapping confirmed by DO. [SN]. epidermal nevus true DOID:0050534 A night blindness that is characterized by hemeralopia with a moderate loss of visual acuity and caused by defective photoreceptor-to-bipolar cell signaling with common ERG findings of reduced or absent b-waves and generally normal a-waves. ICD10CM:H53.63 ICD9CM:368.61 MESH:C537743 OMIM:PS310500 ORDO:215 SNOMEDCT_US_2016_03_01:193687000 SNOMEDCT_US_2016_03_01:193688005 SNOMEDCT_US_2016_03_01:193689002 SNOMEDCT_US_2016_03_01:89208008 UMLS_CUI:C1306122 congenital essential nyctalopia disease_ontology DOID:0050534 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital stationary night blindness DOID:0050535 A retinal vascular disease characterized by the prevention of blood vessel formation at the edges of the retina and the hemorrhage of the blood vessels in the retina. ICD10CM:H35.00 ICD9CM:362.10 OMIM:133780 OMIM:305390 OMIM:601813 OMIM:605750 OMIM:613310 ORDO:891 SNOMEDCT_US_2016_03_01:193355009 SNOMEDCT_US_2016_03_01:31411005 SNOMEDCT_US_2016_03_01:42873008 UMLS_CUI:C0004608 FEVR familial exudative vitreoretinopathy disease_ontology DOID:0050535 Xref MGI. OMIM mapping confirmed by DO. [SN]. exudative vitreoretinopathy DOID:0050544 An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body. OMIM:613752 OMIM:614300 ORDO:289290 hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency disease_ontology DOID:0050544 Xref MGI. OMIM mapping confirmed by DO. [SN]. hypermethioninemia DOID:0050545 A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen. OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 ORDO:450 heterotaxia situs ambiguus disease_ontology DOID:0050545 Xref MGI. OMIM mapping confirmed by DO. [SN]. visceral heterotaxy DOID:0050548 A neuropathy characterized by congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages. OMIM:162400 OMIM:201300 OMIM:256800 OMIM:256860 OMIM:310470 OMIM:608088 OMIM:608654 OMIM:613115 OMIM:613640 OMIM:613708 OMIM:614116 OMIM:614213 OMIM:614653 OMIM:615548 OMIM:615632 OMIM:616488 congenital insensitivity to pain familial dysautonomia, type II hereditary sensory and autonomic neuropathy disease_ontology DOID:0050548 Xref MGI. OMIM mapping confirmed by DO. [SN]. hereditary sensory neuropathy DOID:0050557 A muscular dystrophy that is characterized by diminished muscle tone (hypotonia), progressive muscle weakness and degeneration (atrophy), abnormally fixed joints, spinal rigidity, and delays in reaching motor milestones such as sitting or standing unassisted. ICD9CM:359.0 OMIM:254100 ORDO:97242 SNOMEDCT_US_2016_03_01:111501005 SNOMEDCT_US_2016_03_01:193221009 SNOMEDCT_US_2016_03_01:193224001 UMLS_CUI:C2937300 disease_ontology DOID:0050557 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital muscular dystrophy DOID:0050558 OMIM:254090 ULLRICH DISEASE Ullrich scleroatonic muscular dystrophy disease_ontology DOID:0050558 OMIM mapping confirmed by DO. [SN]. Ullrich congenital muscular dystrophy DOID:0050563 An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms. nonsyndromic hearing loss nonsyndromic hereditary hearing loss disease_ontology DOID:0050563 nonsyndromic deafness DOID:0050564 A nonsyndromic deafness characterized by an autosomal dominant inheritance mode. ICD10CM:H90.3 OMIM:PS124900 ORDO:90635 autosomal dominant deafness disease_ontology DOID:0050564 OMIM mapping confirmed by DO. [SN]. autosomal dominant nonsyndromic deafness DOID:0050566 A nonsyndromic deafness characterized by an X-linked inheritance mode. ICD10CM:H90.3 OMIM:300030 OMIM:300066 OMIM:300614 OMIM:300914 OMIM:304400 OMIM:304500 ORDO:90625 X-linked deafness disease_ontology DOID:0050566 OMIM mapping confirmed by DO. [SN]. X-linked nonsyndromic deafness DOID:0050567 OMIM:119530 OMIM:600625 OMIM:600757 OMIM:602966 OMIM:608371 OMIM:608864 OMIM:608874 OMIM:610361 OMIM:612858 OMIM:613705 OMIM:613857 OMIM:615892 disease_ontology DOID:0050567 Xref MGI. OMIM mapping confirmed by DO. [SN]. orofacial cleft DOID:0050569 An autosomal recessive disease characterized by intrauterine growth retardation and postnatal dwarfism with microcephaly and intellectual disability. ICD10CM:Q87.1 OMIM:210600 OMIM:606744 OMIM:613676 OMIM:613823 OMIM:614728 OMIM:614851 OMIM:615807 ORDO:808 Harper's syndrome Virchow-Seckel dwarfism bird-headed dwarfism microcephalic primordial dwarfism disease_ontology DOID:0050569 Xref MGI. OMIM mapping confirmed by DO. [SN]. Seckel syndrome DOID:0050572 A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells. ICD10CM:H35.5 OMIM:120970 OMIM:300085 OMIM:300476 OMIM:304020 OMIM:600624 OMIM:600977 OMIM:601777 OMIM:602093 OMIM:603649 OMIM:604116 OMIM:605549 OMIM:607476 OMIM:608194 OMIM:610283 OMIM:610381 OMIM:612657 OMIM:612775 OMIM:613660 OMIM:614500 OMIM:615163 OMIM:615374 OMIM:615860 OMIM:615973 ORDO:1872 cone-rod dystrophy 5 cone-rod retinal dystrophy disease_ontology DOID:0050572 Xref MGI. OMIM mapping confirmed by DO. [SN]. cone-rod dystrophy DOID:0050576 An autosomal recessive genetic disease characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. ICD10CM:Q61.5 OMIM:266900 OMIM:606995 OMIM:606996 OMIM:609254 OMIM:610189 OMIM:613615 ORDO:3156 Loken Senior syndrome renal-retinal syndrome disease_ontology DOID:0050576 Xref MGI. OMIM mapping confirmed by DO. [SN]. Senior-Loken syndrome DOID:0050577 OMIM:218330 OMIM:613610 Levin syndrome cranioectodermal dysplasia disease_ontology DOID:0050577 OMIM mapping confirmed by DO. [SN]. Sensenbrenner syndrome DOID:0050578 A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings. OMIM:613587 disease_ontology DOID:0050578 OMIM mapping confirmed by DO. [SN]. occult macular dystrophy DOID:0050580 A lymphedema commonly located_in legs, caused_by congenital abnormalities in the lymphatic system. ICD9CM:757.0 OMIM:153100 OMIM:153200 OMIM:247440 OMIM:611944 OMIM:613480 OMIM:615907 ORDO:79452 SNOMEDCT_US_2016_03_01:205542007 SNOMEDCT_US_2016_03_01:205543002 SNOMEDCT_US_2016_03_01:205546005 SNOMEDCT_US_2016_03_01:75127007 UMLS_CUI:C1313885 Milroy's disease Nonne-Milroy lymphedema disease_ontology DOID:0050580 Xref MGI. OMIM mapping confirmed by DO. [SN]. hereditary lymphedema DOID:0050581 A bone development disease characterized by short fingers and toes. OMIM:112440 OMIM:112450 OMIM:112500 OMIM:112600 OMIM:112700 OMIM:112800 OMIM:112910 OMIM:113000 OMIM:113100 OMIM:113200 OMIM:113300 OMIM:301940 OMIM:607004 OMIM:611377 OMIM:613382 OMIM:615072 ORDO:294937 disease_ontology DOID:0050581 Xref MGI. OMIM mapping confirmed by DO. [SN]. brachydactyly DOID:0050585 OMIM:269700 OMIM:608594 OMIM:612526 OMIM:613327 Beradinelli-Seip syndrome disease_ontology DOID:0050585 OMIM mapping confirmed by DO. [SN]. congenital generalized lipodystrophy DOID:0050589 An intestinal disease characterized by inflammation located_in all parts of digestive tract. EFO:0003767 KEGG:05321 MESH:D015212 NCI:C3138 OMIM:PS266600 SNOMEDCT_US_2016_03_01:155759008 SNOMEDCT_US_2016_03_01:196974002 SNOMEDCT_US_2016_03_01:24526004 SNOMEDCT_US_2016_03_01:266516008 UMLS_CUI:C0021390 disease_ontology DOID:0050589 Xref MGI. OMIM mapping confirmed by DO. [SN]. inflammatory bowel disease DOID:0050591 A tooth disease characterized by failure to develop on or more missing teeth. ICD10CM:K00.0 ICD9CM:520.0 MESH:D000848 OMIM:106600 OMIM:150400 OMIM:313500 OMIM:602639 OMIM:604625 OMIM:610926 ORDO:2227 ORDO:99798 SNOMEDCT_US_2016_03_01:16958000 SNOMEDCT_US_2016_03_01:196265005 SNOMEDCT_US_2016_03_01:196266006 SNOMEDCT_US_2016_03_01:196269004 SNOMEDCT_US_2016_03_01:234951001 SNOMEDCT_US_2016_03_01:26624006 UMLS_CUI:C0399352 familial tooth agenesis hypodontia oligodontia selective tooth agenesis disease_ontology DOID:0050591 Xref MGI. tooth agenesis DOID:0050592 ICD10CM:Q77.2 OMIM:PS208500 ORDO:474 Jeune syndrome short-rib thoracic dysplasia with or without polydactyly thoracic pelvic phalangeal dystrophy disease_ontology DOID:0050592 OMIM mapping confirmed by DO. [SN]. asphyxiating thoracic dystrophy DOID:0050597 A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia. DOID:13692 DOID:13721 DOID:3468 ICD10CM:B65.1 ICD10CM:B65.2 ICD9CM:120.1 ICD9CM:120.2 MESH:D012554 MESH:D012555 NCI:C35001 NCI:C35002 NCI:C35364 OMIM:181460 ORDO:1247 SNOMEDCT_US_2016_03_01:187114003 SNOMEDCT_US_2016_03_01:268058007 SNOMEDCT_US_2016_03_01:52179003 SNOMEDCT_US_2016_03_01:6421008 SNOMEDCT_US_2016_03_01:750009 UMLS_CUI:C0036329 UMLS_CUI:C0036330 UMLS_CUI:C0276932 Katayama fever Schistosoma japonicum infection Schistosoma mansoni infectious disease schistosomiasis japonica disease_ontology DOID:0050597 Xref MGI. intestinal schistosomiasis DOID:0050598 A tuberculosis that occurs at body sites other than the lung. disease_ontology DOID:0050598 extrapulmonary tuberculosis DOID:0050599 An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas. disease_ontology DOID:0050599 abdominal tuberculosis DOID:0050600 An autosomal recessive disease that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB). OMIM:600501 albinism, block lock, cell migration disorder of the neurocytes of the gut, and deafness disease_ontology DOID:0050600 OMIM mapping confirmed by DO. [SN]. ABCD syndrome DOID:0050602 OMIM:231550 Achalasia-Addisonianism-Alacrimia syndrome Allgrove Syndrome disease_ontology DOID:0050602 OMIM mapping confirmed by DO. [SN]. triple-A syndrome DOID:0050608 Askin tumor disease_ontology DOID:0050608 Askin's tumor DOID:0050615 An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract. disease_ontology DOID:0050615 respiratory system cancer DOID:0050619 A respiratory system cancer that is located_in the paranasal sinuses. DOID:1354 DOID:2442 DOID:2765 DOID:2767 DOID:4689 MESH:D010255 NCI:C6014 NCI:C6017 NCI:C6018 NCI:C6019 NCI:C8193 UMLS_CUI:C0280334 UMLS_CUI:C0854995 UMLS_CUI:C1335336 UMLS_CUI:C1335337 UMLS_CUI:C1335340 Epidermoid carcinoma of the paranasal sinus Mucoepidermoid carcinoma of Accessory sinus adenoid cystic carcinoma of Accessory sinus paranasal sinus adenocarcinoma paranasal sinus adenoid cystic carcinoma paranasal sinus mucoepidermoid carcinoma paranasal sinus squamous cell carcinoma disease_ontology adenoid cystic carcinoma of paranasal sinus squamous cell carcinoma of paranasal sinus DOID:0050619 paranasal sinus cancer DOID:0050621 An organ system benign neoplasm that is located_in the respiratory system which extends from the nasal sinuses to the diaphragm. disease_ontology DOID:0050621 respiratory system benign neoplasm DOID:0050622 An organ system benign neoplasm that is located_in reproductive system organs. disease_ontology DOID:0050622 reproductive organ benign neoplasm DOID:0050624 An organ system benign neoplasm located_in gastrointestinal tract organs. disease_ontology DOID:0050624 gastrointestinal system benign neoplasm DOID:0050628 A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning. OMIM:PS604348 ORDO:164736 familial advanced sleep-phase syndrome disease_ontology DOID:0050628 Xref MGI. advanced sleep phase syndrome DOID:0050630 OMIM:300600 FORSIUS-ERIKSSON TYPE OCULAR ALBINISM Forsius-Eriksson syndrome disease_ontology DOID:0050630 Aland Island eye disease DOID:0050632 An autosomal recessive disease characterized by abnormal pigmentation of the skin, hair and eyes. ICD10CM:E70.3 OMIM:203100 OMIM:203200 OMIM:203290 OMIM:606574 OMIM:606952 OMIM:614473 OMIM:615312 ORDO:55 disease_ontology DOID:0050632 Xref MGI. OMIM mapping confirmed by DO. [SN]. oculocutaneous albinism DOID:0050633 OMIM:300500 disease_ontology DOID:0050633 ocular albinism DOID:0050634 OMIM:203655 ALOPECIA UNIVERSALIS CONGENITA disease_ontology DOID:0050634 alopecia universalis DOID:0050639 An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis. OMIM:105250 OMIM:613955 ORDO:137807 PCA familial primary localized cutaneous amyloidosis disease_ontology DOID:0050639 Xref MGI. OMIM mapping confirmed by DO. [SN]. primary cutaneous amyloidosis DOID:0050646 A muscle tissue disease characterized by congenital joint contractures of hand and feet. OMIM:108120 OMIM:108145 OMIM:108200 OMIM:114300 OMIM:121050 OMIM:121070 OMIM:158300 OMIM:178110 OMIM:187370 OMIM:193700 OMIM:601680 OMIM:609128 OMIM:614335 OMIM:615065 ORDO:1147 ORDO:97120 Arthrogryposis Multiplex Congenita Freeman-Sheldon syndrome Freeman-Sheldon syndrome variant Sheldon-Hall syndrome disease_ontology DOID:0050646 Xref MGI. OMIM mapping confirmed by DO. [SN]. distal arthrogryposis DOID:0050647 An X-linked disease that is characterized by profound congenital sensorineural hearing impairment, early-onset hypotonia, delayed motor development, mild to moderate intellectual disability, ataxia, and increased risk of infection and has_material_basis_in mutations of the PRPS1 gene. ICD10CM:E79.8 MESH:C535388 OMIM:301835 ORDO:1187 UMLS_CUI:C0796028 ARTS Lethal ataxia with deafness and optic atrophy MRXS18 MRXSARTS fatal X-linked ataxia with deafness and loss of vision syndromic X-linked mental retardation 18 syndromic X-linked mental retardation Arts type disease_ontology DOID:0050647 OMIM mapping confirmed by DO. [SN]. Arts syndrome DOID:0050650 An atrial fibrillation that has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes. OMIM:607554 OMIM:608583 OMIM:608988 OMIM:611493 OMIM:611494 OMIM:612201 OMIM:612240 OMIM:613055 OMIM:613980 OMIM:614022 OMIM:614049 OMIM:614050 OMIM:615377 OMIM:615378 OMIM:615770 ORDO:334 ATFB disease_ontology DOID:0050650 Xref MGI. familial atrial fibrillation DOID:0050657 OMIM:153480 BANNAYAN-ZONANA SYNDROME RILEY-SMITH SYNDROME RUVALCABA-MYHRE-SMITH SYNDROME disease_ontology DOID:0050657 OMIM mapping confirmed by DO. [SN]. Bannayan-Riley-Ruvalcaba syndrome DOID:0050660 OMIM:123790 disease_ontology DOID:0050660 OMIM mapping confirmed by DO. [SN]. Beare-Stevenson cutis gyrata syndrome DOID:0050661 A macular degeneration that it is characterized by the disruption of cells in a small area near the center of the retina, the macula and may cause progressive vision loss. ICD10CM:H35.5 OMIM:153700 OMIM:153840 OMIM:608161 OMIM:616151 OMIM:616152 ORDO:1243 ORDO:99000 Best disease Best macular dystrophy juvenile-onset vitelliform macular dystrophy disease_ontology DOID:0050661 Xref MGI. OMIM mapping confirmed by DO. [SN]. vitelliform macular dystrophy DOID:0050662 OMIM:611809 autosomal recessive bestrophinopathy disease_ontology DOID:0050662 OMIM mapping confirmed by DO. [SN]. bestrophinopathy DOID:0050665 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction. disease_ontology DOID:0050665 fetal alcohol syndrome DOID:0050667 A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure. ARND static encephalopathy disease_ontology DOID:0050667 alcohol-related neurodevelopmental disorder DOID:0050670 A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing. hypotonic cerebral palsy disease_ontology DOID:0050670 ataxic cerebral palsy DOID:0050675 OMIM:612292 BIRK-BAREL MENTAL RETARDATION DYSMORPHISM SYNDROME disease_ontology DOID:0050675 OMIM mapping confirmed by DO. [SN]. Birk-Barel syndrome DOID:0050676 OMIM:135150 disease_ontology DOID:0050676 OMIM mapping confirmed by DO. [SN]. Birt-Hogg-Dube syndrome DOID:0050678 An autosomal dominant disease characterized by familial granulomatous arthritis, uveitis and skin granulomas. It has material basis in mutations in the NOD2/CARD15 genes. NCI:C116794 OMIM:186580 SNOMEDCT:699861000 ARTHROCUTANEOUVEAL GRANULOMATOSIS Jabs syndrome disease_ontology DOID:0050678 OMIM mapping confirmed by DO. [SN]. Blau syndrome DOID:0050685 A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells. snadendla 2011-06-13T01:25:14Z DOID:7137 NCI:C4099 SNOMEDCT_US_2016_03_01:189557009 SNOMEDCT_US_2016_03_01:5958006 UMLS_CUI:C0334239 Small cell carcinoma - intermediate cell Small cell carcinoma, intermediate cell (morphologic abnormality) intermediate cell small cell carcinoma disease_ontology DOID:0050685 small cell carcinoma DOID:0050686 A cancer that is classified based on the organ it starts in. snadendla 2011-06-13T03:28:33Z MESH:D009371 disease_ontology DOID:0050686 organ system cancer DOID:0050687 A cancer that is classified by the type of cell from which it is derived. snadendla 2011-06-13T03:28:50Z disease_ontology DOID:0050687 cell type cancer DOID:0050689 snadendla 2011-06-17T03:55:47Z OMIM:610713 disease_ontology DOID:0050689 OMIM mapping confirmed by DO. [SN]. brachydactyly-syndactyly syndrome DOID:0050696 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy. lschriml 2011-12-01T01:01:25Z disease_ontology DOID:0050696 fetal alcohol spectrum disorder DOID:0050699 A renal tubular transport disease that is characterized by tubular proteinuria, hypercalciuria, calcium nephrolithiasis, nephrocalcinosis and chronic kidney failure and has_material_basis_in X-linked recessive inheritance of mutations in the CLCN5 gene or OCRL1 gene. lschriml 2015-03-12T14:32:47Z MESH:C538212 MESH:C564487 MESH:D057973 NCI:C123260 OMIM:300009 OMIM:300555 ORDO:1652 SNOMEDCT_US_2016_03_01:444645005 UMLS_CUI:C0878681 UMLS_CUI:C1845167 UMLS_CUI:C1848336 Dent disease 1 Dent disease 2 Dent's disease disease_ontology DOID:0050699 Dent disease DOID:0050700 A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. lschriml 2012-01-03T02:54:11Z ICD10CM:I42 ICD10CM:I42.9 ICD10CM:I51.5 ICD9CM:425 ICD9CM:425.9 MESH:D009202 NCI:C34830 NCI:C53654 SNOMEDCT_US_2016_03_01:155351008 SNOMEDCT_US_2016_03_01:155353006 SNOMEDCT_US_2016_03_01:195035002 SNOMEDCT_US_2016_03_01:195037005 SNOMEDCT_US_2016_03_01:20072003 SNOMEDCT_US_2016_03_01:266244008 SNOMEDCT_US_2016_03_01:266301006 SNOMEDCT_US_2016_03_01:57809008 SNOMEDCT_US_2016_03_01:85898001 SNOMEDCT_US_2016_03_01:89461002 SNOMEDCT_US_2016_03_01:89600009 UMLS_CUI:C0033141 UMLS_CUI:C0036529 UMLS_CUI:C0878544 Cardiomyopathies disease_ontology DOID:0050700 MESH:D009202 added from NeuroDevNet [WAK]. cardiomyopathy DOID:0050701 An epilepsy syndrome that is a group of clinical entities showing a cluster of electro-clinical characteristics, classified according to age at onset, cognitive and developmental antecedents and consequences, motor and sensory examinations, EEG features, provoking or triggering factors, and patterns of seizure occurrence with respect to sleep. lschriml 2012-04-11T11:42:46Z electro-clinical syndrome disease_ontology DOID:0050701 electroclinical syndrome DOID:0050702 An electroclinical syndrome with onset in the neonatal period less than 44 weeks of gestational age. lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050702 neonatal period electroclinical syndrome DOID:0050703 An electroclinical syndrome with onset in infancy occurring between birth and one year of age. lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050703 infancy electroclinical syndrome DOID:0050704 An electroclinical syndrome with onset in childhood between one and 12 years of age. lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050704 childhood electroclinical syndrome DOID:0050705 An electroclinical syndrome with onset in adolescence and adulthood. lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050705 adolescence-adult electroclinical syndrome DOID:0050706 lschriml 2012-04-11T11:48:18Z disease_ontology DOID:0050706 variable age at onset electroclinical syndrome DOID:0050709 A neonatoal period electroclinical syndrome that is characterized by tonic spasms and partial seizures. lschriml 2012-05-10T10:02:58Z OMIM:300088 OMIM:300607 OMIM:300672 OMIM:308350 OMIM:609304 OMIM:612164 OMIM:613402 OMIM:613477 OMIM:613720 OMIM:613721 OMIM:613722 OMIM:614558 OMIM:614959 OMIM:615006 OMIM:615338 OMIM:615473 OMIM:615476 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 15 Early Infantile Epileptic Encephalopathy Early Infantile Epileptic Encephalopathy with Burst-Suppression disease_ontology DOID:0050709 Ohtahara syndrome DOID:0050711 An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus. lschriml 2012-05-22T11:47:25Z OMIM:604290 disease_ontology DOID:0050711 aceruloplasminemia DOID:0050725 A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels. lschriml 2012-06-13T03:09:31Z OMIM:276600 Oculocutaneous tyrosinemia Richner-Hanhart syndrome disease_ontology DOID:0050725 tyrosinemia type II DOID:0050728 A carbohydrate metabolism disorder that is characterized by abnormal accumulation or depletion of liver glycogen. lschriml 2012-07-13T10:42:54Z disease_ontology DOID:0050728 glycogen metabolism disorder DOID:0050735 A monogenic disease that has_material_basis_in muations in genes on the X chromosome. lschriml 2012-07-24T12:47:31Z disease_ontology DOID:0050735 X-linked disease DOID:0050736 An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease. lschriml 2012-07-24T12:51:47Z disease_ontology DOID:0050736 autosomal dominant disease DOID:0050737 An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop. lschriml 2012-07-24T12:51:47Z disease_ontology DOID:0050737 autosomal recessive disease DOID:0050739 A monogenic disease that is has material basis in a mutation in a single gene on one of the non-sex chromosomes. lschriml 2012-07-24T04:45:53Z disease_ontology DOID:0050739 autosomal genetic disease DOID:0050741 lschriml 2012-09-05T11:48:42Z EFO:0003829 KEGG:05034 MESH:D010610 NCI:C3325 OMIM:103780 SNOMEDCT_US_2016_03_01:126685009 SNOMEDCT_US_2016_03_01:95001001 UMLS_CUI:C0031347 alcoholism disease_ontology DOID:0050741 alcohol dependence DOID:0050742 lschriml 2012-09-05T11:48:42Z EFO:0003768 ICD10CM:F17 ICD10CM:F17.2 ICD10CM:F17.20 MESH:D014029 NCI:C54203 OMIM:188890 SNOMEDCT_US_2016_03_01:56294008 UMLS_CUI:C0028043 tobacco use disorder disease_ontology DOID:0050742 nicotine dependence DOID:0050743 A non-Hodgkin lymphoma that has_material_basis_in mature T lymphocytes and natural killer cells. lschriml 2012-09-18T01:56:52Z NK-T cell lymphoma mature T-cell and natural killer cell lymphoma disease_ontology DOID:0050743 mature T-cell and NK-cell lymphoma DOID:0050744 A non-Hodgkin lymphoma involving aberrant T-cells. lschriml 2012-09-18T01:57:40Z disease_ontology DOID:0050744 anaplastic large cell lymphoma DOID:0050745 A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body. lschriml 2012-09-18T01:58:25Z disease_ontology DOID:0050745 diffuse large B-cell lymphoma DOID:0050746 A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. lschriml 2012-09-18T02:00:45Z MESH:D020522 disease_ontology DOID:0050746 mantle cell lymphoma DOID:0050749 A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus. lschriml 2012-09-18T02:01:49Z disease_ontology DOID:0050749 peripheral T-cell lymphoma DOID:0050753 A cerebellar disease characterized by ataxia originating in the cerebellum. lschriml 2013-01-16T01:07:02Z disease_ontology DOID:0050753 cerebellar ataxia DOID:0050757 A mitochondrial metabolism disease that is characterized by hearing loss that begins early in life, problems with movement, impaired vision, and behavior problems. lschriml 2013-01-16T01:20:50Z OMIM:304700 Deafness Dystonia Optic Atrophy Syndrome Deafness Dystonia Optic Neuronopathy Syndrome (DDON) Dystonia Deafness Syndrome Mohr-Tranebjaerg Syndrome disease_ontology DOID:0050757 deafness dystonia syndrome DOID:0050758 A lactic acidosis that has_material_basis_in high levels of acid. lschriml 2013-01-16T01:23:37Z disease_ontology DOID:0050758 metabolic acidosis DOID:0050765 lschriml 2013-01-17T12:54:19Z disease_ontology DOID:0050765 neuroacanthocytosis DOID:0050766 A neuroacanthocytosis that has_material_basis_in homozygous or compound heterozygous mutation in the VPS13A gene, which encodes chorein, on chromosome 9q21; it is characterized by progressive neurodegeneration and red cell acanthocytosis, with onset in the third to fifth decade of life. lschriml 2013-01-17T12:54:19Z ICD10CM:E78.6 OMIM:200150 ORDO:2388 UMLS_CUI:C0393576 Levine-Critchley syndrome choreoacanthocytosis disease_ontology DOID:0050766 chorea-acanthocytosis DOID:0050770 lschriml 2013-02-21T11:36:13Z OMIM:174050 disease_ontology DOID:0050770 polycystic liver disease DOID:0050771 lschriml 2013-02-21T11:40:58Z OMIM:171300 disease_ontology DOID:0050771 phaeochromocytoma DOID:0050773 lschriml 2013-02-21T11:51:57Z MESH:D010235 NCI:C3308 OMIM:115310 OMIM:168000 OMIM:601650 OMIM:605373 OMIM:614165 SNOMEDCT_US_2016_03_01:127027008 SNOMEDCT_US_2016_03_01:189743009 SNOMEDCT_US_2016_03_01:253029009 SNOMEDCT_US_2016_03_01:302833002 SNOMEDCT_US_2016_03_01:72787006 SNOMEDCT_US_2016_03_01:803009 UMLS_CUI:C0030421 chemodectoma disease_ontology DOID:0050773 Xref MGI. paraganglioma DOID:0050776 A non-syndromic intellectual disability characterized by a X-linked inheritance pattern. lschriml 2013-02-21T12:06:40Z OMIM:300046 OMIM:300047 OMIM:300062 OMIM:300114 OMIM:300115 OMIM:300143 OMIM:300210 OMIM:300271 OMIM:300324 OMIM:300355 OMIM:300372 OMIM:300387 OMIM:300428 OMIM:300433 OMIM:300436 OMIM:300454 OMIM:300498 OMIM:300504 OMIM:300505 OMIM:300518 OMIM:300558 OMIM:300577 OMIM:300659 OMIM:300716 OMIM:300802 OMIM:300803 OMIM:300844 OMIM:300848 OMIM:300849 OMIM:300850 OMIM:300851 OMIM:300852 OMIM:300912 OMIM:300919 OMIM:300923 OMIM:309530 OMIM:309549 ORDO:777 non-specific X-linked mental retardation disease_ontology DOID:0050776 Xref MGI. non-syndromic X-linked intellectual disability DOID:0050777 A ciliopathy that is characterized by congenital malformation of the brainstem and agenesis or hypoplasia of the cerebellar vermis leading to an abnormal respiratory pattern, nystagmus, hypotonia, ataxia, and delay in achieving motor milestones. lschriml 2013-04-04T11:25:32Z OMIM:213300 OMIM:300804 OMIM:608091 OMIM:608629 OMIM:609583 OMIM:610188 OMIM:610688 OMIM:611560 OMIM:612285 OMIM:612291 OMIM:614173 OMIM:614424 OMIM:614464 OMIM:614465 OMIM:614615 OMIM:614815 OMIM:614970 OMIM:615636 OMIM:615665 OMIM:616654 ORDO:475 JBTS disease_ontology DOID:0050777 Xref MGI. Joubert syndrome DOID:0050778 A ciliopathy that is characterized by renal cystic dysplasia, occipital encephalocele, polydactyly (post axial), hepatic developmental defects, and pulmonary hypoplasia. lschriml 2013-04-04T11:28:16Z ICD9CM:753.1 ICD9CM:753.10 OMIM:249000 OMIM:267010 OMIM:603194 OMIM:607361 OMIM:611134 OMIM:611561 OMIM:612284 OMIM:613885 OMIM:614175 OMIM:614209 OMIM:615397 ORDO:564 SNOMEDCT_US_2016_03_01:204954005 SNOMEDCT_US_2016_03_01:204966004 SNOMEDCT_US_2016_03_01:236440007 SNOMEDCT_US_2016_03_01:82525005 UMLS_CUI:C0311245 Meckel-Gruber syndrome disease_ontology DOID:0050778 Xref MGI. Meckel syndrome DOID:0050782 A syndrome that is haracterized by the development of a one or more tumors (gastrinoma) in the pancreas, duodenum, or both that secrete excessive levels of gastrin, a hormone that stimulates production of acid by the stomach. lschriml 2013-10-23T12:51:49Z ICD10CM:E16.4 MESH:D015043 NCI:C3453 SNOMEDCT_US_2016_03_01:154694003 SNOMEDCT_US_2016_03_01:190443003 SNOMEDCT_US_2016_03_01:267477002 SNOMEDCT_US_2016_03_01:53132006 UMLS_CUI:C0043515 disease_ontology DOID:0050782 Zollinger-Ellison syndrome DOID:0050783 A multiple sclerosis that is characterised by a worsening of disability, rather than by relapses followed by recovery, which progressively worsens until a steady progression of disability replaces the cycles of attacks. lschriml 2013-11-07T11:22:49Z MESH:D020528 SNOMEDCT_US_2016_03_01:425500002 UMLS_CUI:C0751965 SPMS Secondary-progressive MS disease_ontology DOID:0050783 secondary progressive multiple sclerosis DOID:0050785 A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset. lschriml 2013-11-07T11:32:37Z MESH:D020528 SNOMEDCT_US_2016_03_01:230374002 UMLS_CUI:C0393666 PRMS Progressive-relapsing MS disease_ontology DOID:0050785 progressive relapsing multiple sclerosis DOID:0050787 An autosomal dominant disease that is characterized by predisposition to hamartomatous benign polyps in the gastrointestinal tract, specifically in the stomach, small intestine, colon, and rectum. lschriml 2013-11-12T11:25:28Z OMIM:174900 disease_ontology DOID:0050787 juvenile polyposis syndrome DOID:0050788 An autosomal dominant disease that is characterized by ankylosis of the proximal interphalangeal joints, carpal and tarsal bone fusion, and conductive deafness. lschriml 2013-11-12T11:43:22Z KEGG:H00484 OMIM:185800 Cushing's symphalangism disease_ontology DOID:0050788 proximal symphalangism DOID:0050789 An autosomal dominant disease that is characterized by fusion of the carpals, tarsals, and phalanges, short first metacarpals causing brachydactyly; and humeroradial fusion. lschriml 2013-11-12T11:50:00Z OMIM:186570 disease_ontology DOID:0050789 tarsal-carpal coalition syndrome DOID:0050791 A pseudohermaphroditism that is characterized by the persistence of Mullerian duct derivatives (i.e. uterus, cervix, fallopian tubes and upper two thirds of vagina) in a phenotypically and karyotypically male. lschriml 2013-11-12T12:26:49Z MESH:C536665 NCI:C120188 OMIM:261550 SNOMEDCT_US_2016_03_01:702358005 UMLS_CUI:C1849930 persistent Muellerian duct syndrome disease_ontology DOID:0050791 persistent Mullerian duct syndrome DOID:0050792 An autosomal dominant disease that is characterized by multiple bluish cutaneous or mucosal venous lesions. lschriml 2013-11-12T12:38:33Z OMIM:600195 disease_ontology DOID:0050792 multiple cutaneous and mucosal venous malformations DOID:0050793 A heart conduction disease that is characterized by heart arrhythmia defined as a short QT interval on an EKG (less than 300 ms) that does not significantly change with heart rate, tall and peaked T waves, and a structurally normal heart. lschriml 2013-11-12T12:59:42Z OMIM:609620 OMIM:609621 OMIM:609622 disease_ontology DOID:0050793 short QT syndrome DOID:0050794 A dysostosis that is characterized by premature joint ankylosis and has_material_basis_in autosomal dominant inhertitance. lschriml 2013-11-12T01:08:42Z OMIM:186500 OMIM:610017 OMIM:612961 disease_ontology DOID:0050794 multiple synostoses syndrome DOID:0050795 A retinal disease that is characterized by the loss of cone cells, the photoreceptors responsible for both central and color vision. lschriml 2013-11-12T01:19:22Z OMIM:180020 OMIM:610024 OMIM:610356 OMIM:610478 OMIM:613093 retinal cone dystrophy disease_ontology DOID:0050795 cone dystrophy DOID:0050801 lschriml 2013-11-21T12:48:07Z OMIM:109200 OMIM:300710 OMIM:612421 alopecia androgenetica, male pattern baldness androgenetic alopecia disease_ontology DOID:0050801 androgenic alopecia DOID:0050811 A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency. lschriml 2013-12-04T12:52:02Z ICD10CM:E25 ICD10CM:E25.9 ICD9CM:255.2 OMIM:201710 OMIM:201810 OMIM:201910 OMIM:202010 OMIM:202110 ORDO:418 SNOMEDCT_US_2016_03_01:154706003 SNOMEDCT_US_2016_03_01:190510000 SNOMEDCT_US_2016_03_01:190519004 SNOMEDCT_US_2016_03_01:267395000 UMLS_CUI:C0701163 adrenal hyperplasia 1 congenital lipoid adrenal hyperplasia lipoid CAH disease_ontology DOID:0050811 Xref MGI. congenital adrenal hyperplasia DOID:0050815 An eye and adnexa disease that is located_in the adnexa of the eye. lschriml 2013-12-05T12:55:42Z disease_ontology DOID:0050815 eye adnexa disease DOID:0050816 An autosomal recessive disease that is characterized by inverted facial expressions in association with a severe and early-onset form of dysfunctional urinary voiding. lschriml 2013-12-05T01:10:52Z OMIM:236730 OMIM:615112 Ochoa syndrome hydronephrosis with peculiar facial expression disease_ontology DOID:0050816 urofacial syndrome DOID:0050820 A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart. lschriml 2014-02-12T01:35:05Z ICD10CM:I44.3 ICD10CM:I44.30 ICD9CM:426.10 MESH:D054537 NCI:C26703 SNOMEDCT_US_2016_03_01:195040005 SNOMEDCT_US_2016_03_01:195043007 SNOMEDCT_US_2016_03_01:233917008 SNOMEDCT_US_2016_03_01:58547007 UMLS_CUI:C0004245 AV block disease_ontology DOID:0050820 atrioventricular block DOID:0050824 A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm. lschriml 2014-02-12T01:47:54Z SA node sinuatrial node disease_ontology DOID:0050824 sinoatrial node disease DOID:0050825 A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart. lschriml 2014-02-12T01:53:42Z disease_ontology DOID:0050825 endocardium disease DOID:0050826 lschriml 2014-02-12T02:55:24Z DOID:13834 ICD10CM:I07 ICD10CM:I07.9 ICD9CM:397.0 SNOMEDCT_US_2016_03_01:155289000 SNOMEDCT_US_2016_03_01:194745002 SNOMEDCT_US_2016_03_01:266282000 SNOMEDCT_US_2016_03_01:49699002 UMLS_CUI:C0264776 RH. tricuspid valve disease Rheumatic disease of tricuspid valve (disorder) Rheumatic tricuspid valve disease NOS (disorder) Tricuspid disease disease of tricuspid valve rheumatic tricuspid valve disease disease_ontology DOID:0050826 tricuspid valve disease DOID:0050828 A vascular disease that is located_in an artery. lschriml 2014-02-12T03:08:35Z disease_ontology DOID:0050828 artery disease DOID:0050829 A cardiovascular system disease that is located_in the fibrous sac surrounding the heart. lschriml 2014-02-18T12:20:15Z disease_ontology DOID:0050829 pericardium disease DOID:0050830 An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs. lschriml 2014-02-18T12:41:09Z disease_ontology DOID:0050830 peripheral artery disease DOID:0050834 A syndrome that is acterized by a pattern of congenital anomalies including choanal atresia and malformations of the heart, inner ear, and retina. lschriml 2014-03-18T11:58:38Z ICD10:Q89.8 MESH:D058747 NCI:C75100 OMIM:214800 ORDO:138 SNOMEDCT_US_2016_03_01:394529000 SNOMEDCT_US_2016_03_01:47535005 UMLS_CUI:C0265354 UMLS_CUI:C2936502 CHARGE association disease_ontology DOID:0050834 CHARGE syndrome DOID:0050835 A dystonia that affects most or all of the body. lschriml 2014-03-18T01:13:36Z DOID:11910 DOID:11911 DOID:11912 DOID:14164 DOID:5159 DOID:531 ICD10CM:G24.1 ICD10CM:G24.2 ICD9CM:333.6 ICD9CM:333.8 MESH:D004422 MESH:D020821 NCI:C34564 NCI:C35437 NCI:C35438 NCI:C35527 SNOMEDCT_US_2016_03_01:155008004 SNOMEDCT_US_2016_03_01:192852006 SNOMEDCT_US_2016_03_01:192853001 SNOMEDCT_US_2016_03_01:192858005 SNOMEDCT_US_2016_03_01:192859002 SNOMEDCT_US_2016_03_01:192862004 SNOMEDCT_US_2016_03_01:22451001 SNOMEDCT_US_2016_03_01:230318005 SNOMEDCT_US_2016_03_01:230321007 SNOMEDCT_US_2016_03_01:267584007 SNOMEDCT_US_2016_03_01:431034009 SNOMEDCT_US_2016_03_01:55776008 SNOMEDCT_US_2016_03_01:57937000 UMLS_CUI:C0013423 UMLS_CUI:C0154674 UMLS_CUI:C0154675 UMLS_CUI:C0393598 UMLS_CUI:C0393601 UMLS_CUI:C0752207 Idiopathic torsion dystonia dystonia deformans progressiva dystonia musculorum deformans familial dystonia fragments of torsion dystonia idiopathic familial dystonia idiopathic non-familial dystonia symptomatic torsion dystonia disease_ontology Dystonia 12 DOID:0050835 MESH:C538001 added from NeuroDevNet [WAK]. generalized dystonia DOID:0050836 A dystonia that is localized to a specific part of the body. lschriml 2014-03-18T01:13:36Z disease_ontology DOID:0050836 focal dystonia DOID:0050840 A focal dystonia that is characterized by simultaneous contraction of the agonist and antagonist muscles that control the position of the head contracting during dystonic movement which causes the neck to involuntarily turn to the left, right, upwards, and/or downwards. lschriml 2014-03-18T01:30:33Z spasmodic torticollis disease_ontology DOID:0050840 cervical dystonia DOID:0050847 A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep. lschriml 2014-03-20T03:57:22Z disease_ontology DOID:0050847 sleep apnea DOID:0050848 A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep. lschriml 2014-03-20T03:57:22Z ICD10CM:G47.3 ICD10CM:G47.30 ICD9CM:780.57 MESH:D012891 NCI:C26884 OMIM:107650 SNOMEDCT_US_2016_03_01:155614007 SNOMEDCT_US_2016_03_01:194441007 SNOMEDCT_US_2016_03_01:196166002 SNOMEDCT_US_2016_03_01:206750008 SNOMEDCT_US_2016_03_01:230493001 SNOMEDCT_US_2016_03_01:313246000 SNOMEDCT_US_2016_03_01:73430006 UMLS_CUI:C0020529 UMLS_CUI:C0037315 UMLS_CUI:C0338495 obstructive sleep apnea syndrome disease_ontology DOID:0050848 Xref MGI. obstructive sleep apnea DOID:0050852 lschriml 2014-04-15T03:46:27Z disease_ontology DOID:0050852 limb ischemia DOID:0050854 lschriml 2014-04-15T03:53:41Z disease_ontology DOID:0050854 Muckle-Wells syndrome DOID:0050856 lschriml 2014-04-15T04:03:08Z disease_ontology DOID:0050856 oppositional defiant disorder DOID:0050860 lschriml 2014-05-05T03:14:49Z disease_ontology DOID:0050860 colorectal adenoma DOID:0050871 lschriml 2014-06-25T05:14:03Z disease_ontology DOID:0050871 fibroma DOID:0050877 A pancreas disease that is characterized by the failure of the pancreas to develop prior to birth. lschriml 2014-07-09T03:35:41Z OMIM:260370 partial pancreatic agenesis disease_ontology DOID:0050877 pancreatic agenesis DOID:0050880 A syndrome that is characterized by developmental delay, intellectual disability, muscle weakness (hypotonia), epilepsy, distinctive facial features and congenital malformations of the heart, urogenital tract and the central nervous system, and has_physical_basis_in either a chromosome 17 (17q21.31) microdeletion or a mutation in the KANSL1-gene. lschriml 2014-08-06T12:57:12Z OMIM:610443 ORDO:96169 17q21.31 microdeletion syndrome KANSL1-related intellectual disability syndrome KdVS Koolen-De Vries syndrome disease_ontology DOID:0050880 Koolen de Vries syndrome DOID:0050882 An autosomal dominant cerebellar ataxia that is characterized by the early-onset of cerebellar signs and eye movement abnormalities with a very slow disease progression, and has material basis in mutation in the SPTBN2 gene. lschriml 2014-08-06T03:51:03Z OMIM:600224 disease_ontology DOID:0050882 spinocerebellar ataxia type 5 DOID:0050888 An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms. lschriml 2014-08-14T10:55:32Z OMIM:300486 OMIM:300860 OMIM:309583 disease_ontology DOID:0050888 syndromic intellectual disability DOID:0050889 An intellectual disability that is characterized by the absence of associated medical and behavioral signs and symptoms. lschriml 2014-08-14T10:57:36Z OMIM:613192 OMIM:614202 disease_ontology DOID:0050889 non-syndromic intellectual disability DOID:0050890 A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. lschriml 2014-08-14T03:29:17Z alpha Synucleinopathies disease_ontology Synucleinopathies DOID:0050890 synucleinopathy DOID:0050891 An adrenal adenoma that is a benign tumor of the adrenal cortex. lschriml 2014-09-04T01:54:59Z adrenocortical adenoma disease_ontology DOID:0050891 adrenal cortical adenoma DOID:0050894 A cell type benign neoplasm that has_material_basis_in odontogenic epithelium. lschriml 2014-09-11T02:44:50Z disease_ontology DOID:0050894 ameloblastoma DOID:0050902 An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor. lschriml 2014-10-06T14:36:37Z DOID:0060105 DOID:168 DOID:3858 DOID:4981 MESH:D008527 MESH:D018242 NCI:C27294 NCI:C3222 NCI:C3716 OMIM:155255 SNOMEDCT_US_2016_03_01:189921005 SNOMEDCT_US_2016_03_01:189925001 SNOMEDCT_US_2016_03_01:189933000 SNOMEDCT_US_2016_03_01:39781001 SNOMEDCT_US_2016_03_01:443333004 SNOMEDCT_US_2016_03_01:55045006 SNOMEDCT_US_2016_03_01:699028006 SNOMEDCT_US_2016_03_01:83217000 UMLS_CUI:C0025149 UMLS_CUI:C0206663 UMLS_CUI:C1334410 CNS PNET CPNET brain medulloblastoma infratentorial primitive neuroectodermal tumor localized primitive neuroectodermal tumor disease_ontology DOID:0050902 OMIM mapping confirmed by DO. [SN]. medulloblastoma DOID:0050904 A salivary gland cancer that has_material_basis_in epithelial cells. lschriml 2014-10-08T16:52:58Z disease_ontology DOID:0050904 salivary gland carcinoma DOID:0050908 A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets. lschriml 2014-10-13T12:51:33Z ICD9:238.7 MESH:D009190 OMIM:614286 UMLS_CUI:C2713368 disease_ontology DOID:0050908 myelodysplastic syndrome DOID:0050909 A non-Hodgkin lymphoma that has_material_basis_in mucosal tissue involved in antibody production. lschriml 2014-10-13T14:17:40Z mucosa-associated lymphoid tissue lymphoma disease_ontology DOID:0050909 MALT lymphoma DOID:0050913 A large intestine cancer that has_material_basis_in epithelial cells of glandular origin. lschriml 2014-10-13T15:00:10Z disease_ontology DOID:0050913 large intestine adenocarcinoma DOID:0050922 A gastrointestinal system cancer that has_material_basis_in epithelial cells. lschriml 2014-10-21T11:56:36Z disease_ontology DOID:0050922 gastrointestinal carcinoma DOID:0050936 An adrenal medulla cancer that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin. lschriml 2014-10-22T10:25:45Z disease_ontology DOID:0050936 extra-adrenal pheochromocytoma DOID:0050948 A rickets characterized by low levels of serum phosphate and elevated levels of ALP and phosphaturia and that has_material_basis_in autosomal dominant inheritance. lschriml 2015-10-01T12:10:30Z OMIM:193100 disease_ontology DOID:0050948 autosomal dominant hypophosphatemic rickets DOID:0050950 A hereditary ataxia that has_material_basis_in autosomal recessive inheritance. lschriml 2015-10-05T14:21:08Z disease_ontology DOID:0050950 autosomal recessive cerebellar ataxia DOID:0050951 A neurodegenerative disease that is characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements. lschriml 2015-10-05T14:38:17Z disease_ontology DOID:0050951 hereditary ataxia DOID:0050952 lschriml 2015-10-05T14:39:34Z disease_ontology DOID:0050952 spastic ataxia DOID:0050955 lschriml 2015-10-05T16:07:27Z OMIM:183090 disease_ontology DOID:0050955 spinocerebellar ataxia type 2 DOID:0050958 lschriml 2015-10-05T16:07:27Z OMIM:164500 disease_ontology DOID:0050958 spinocerebellar ataxia type 7 DOID:0050961 lschriml 2015-10-05T16:12:39Z OMIM:604432 disease_ontology DOID:0050961 spinocerebellar ataxia type 11 DOID:0050963 lschriml 2015-10-05T16:12:39Z OMIM:605259 disease_ontology DOID:0050963 spinocerebellar ataxia type 13 DOID:0050964 lschriml 2015-10-05T16:12:39Z OMIM:605361 disease_ontology DOID:0050964 spinocerebellar ataxia type 14 DOID:0050970 lschriml 2015-10-06T16:11:07Z OMIM:607346 disease_ontology DOID:0050970 spinocerebellar ataxia type 19/22 DOID:0050973 lschriml 2015-10-06T16:11:07Z OMIM:610245 disease_ontology DOID:0050973 spinocerebellar ataxia type 23 DOID:0050980 lschriml 2015-10-06T16:11:07Z OMIM:117210 disease_ontology DOID:0050980 spinocerebellar ataxia type 31 DOID:0050989 lschriml 2015-10-06T16:26:26Z OMIM:160120 disease_ontology DOID:0050989 episodic ataxia type 1 DOID:0050999 lschriml 2015-10-07T14:43:23Z OMIM:613728 SCAR10 disease_ontology DOID:0050999 autosomal recessive spinocerebellar ataxia 10 DOID:0060001 A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol. disease_ontology DOID:0060001 withdrawal disorder DOID:0060005 A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system. disease_ontology DOID:0060005 autoimmune disease of endocrine system DOID:0060013 A severe combined immunodeficiency that is a X-linked SCID that has material basis in mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells. DOID:5811 MESH:D053632 NCI:C4682 OMIM:300400 SNOMEDCT_US_2016_03_01:203592006 SNOMEDCT_US_2016_03_01:234569003 UMLS_CUI:C1279481 SCID-X1 X-Linked Severe Combined Immunodeficiency XSCID thymic epithelial hypoplasia disease_ontology DOID:0060013 OMIM mapping confirmed by DO. [LS]. gamma chain deficiency DOID:0060014 A severe combined immunodeficiency that is an autosomal recessive disease with T and B lymphocyte dysfunction, due to a large deletion at one allelle and a point mutation at the other. The point mutation resulted in the alteration of intervening sequence 13 donor splice site. The population of T lymphocytes is diminished and unresponsive to mitogen stimulation. The level of B lymphocyte numbers, serum immunoglobulin decreased with age. disease_ontology DOID:0060014 CD45 deficiency DOID:0060015 A severe combined immunodeficiency that results from defective IL7R expression causes T-B+NK+ SCID. Loss of IL-7R function leads to the loss of an antiapoptotic signal, resulting in a loss of T-cell selection in thymus. IL-7R disease_ontology DOID:0060015 interleukin-7 receptor alpha deficiency DOID:0060020 A severe combined immunodeficiency that is the most severe form of SCID and has material basis in mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions. DOID:1226 MESH:C538361 NCI:C27070 OMIM:267500 SNOMEDCT_US_2016_03_01:111584000 UMLS_CUI:C0272167 De Vaal disease disease_ontology aleukocytosis DOID:0060020 OMIM mapping confirmed by DO. [SN]. reticular dysgenesis DOID:0060021 A combined T cell and B cell immunodeficiency that has material basis in a mutation in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay. OMIM:606593 LIG4 Syndrome disease_ontology DOID:0060021 OMIM mapping confirmed by DO. [SN]. DNA ligase IV deficiency DOID:0060028 An agammaglobulinemia that is a condition where there is co-occurrence of deficient cell-mediated immunity and benign thymoma. thymoma with hypogammaglobulinemia disease_ontology DOID:0060028 Good syndrome DOID:0060031 A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract. disease_ontology DOID:0060031 autoimmune disease of gastrointestinal tract DOID:0060032 An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system. disease_ontology DOID:0060032 autoimmune disease of musculoskeletal system DOID:0060033 An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system. disease_ontology DOID:0060033 autoimmune disease of peripheral nervous system DOID:0060036 A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause. disease_ontology DOID:0060036 intrinsic cardiomyopathy DOID:0060037 A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. disease_ontology DOID:0060037 developmental disorder of mental health DOID:0060038 A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination. disease_ontology DOID:0060038 specific developmental disorder DOID:0060040 A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors. DOID:1208 ICD9CM:299.80 UMLS_CUI:C0154451 pervasive development disorder disease_ontology DOID:0060040 pervasive developmental disorder DOID:0060041 A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior. disease_ontology DOID:0060041 autism spectrum disorder DOID:0060042 An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism. PDD NOS disease_ontology DOID:0060042 atypical autism DOID:0060043 A disease of mental health that involves the impairment in normal sexual functioning. disease_ontology DOID:0060043 sexual disorder DOID:0060045 A factitious disorder that involves a care giver's deliberate exaggeration, fabrication, and/or induce physical, psychological, behavioral, and/or mental health problems in others. disease_ontology DOID:0060045 Munchausen by proxy DOID:0060046 A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language. disease_ontology DOID:0060046 aphasia DOID:0060047 A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition. disease_ontology DOID:0060047 writing disorder DOID:0060049 A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract. disease_ontology DOID:0060049 autoimmune disease of urogenital tract DOID:0060050 A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood. disease_ontology DOID:0060050 autoimmune disease of blood DOID:0060053 A neuropathy that is located_in nerves of the peripheral nervous system. disease_ontology DOID:0060053 obsolete peripheral neuropathy true DOID:0060055 An autosomal dominant disease characterized by abnormal development of the face, skin and genitals. Clinical expressions of the disease include cleft lip, with or without cleft palate, contractures of the lower extremities, abnormal external genitalia, syndactyly of fingers and/or toes, and a pyramidal skin fold over the hallux nail. It has material basis in mutations in the IRF6 gene on chromosome 1. emitraka 2015-02-04T14:16:39Z MESH:C562509 NCI:C118786 OMIM:119500 OMIM:263650 ORDO:1300 ORDO:294963 SNOMEDCT_US_2016_03_01:205820002 SNOMEDCT_US_2016_03_01:66783006 UMLS_CUI:C0265259 facio-genito-popliteal syndrome popliteal web syndrome disease_ontology DOID:0060055 NT MGI. popliteal pterygium syndrome DOID:0060056 An immune system disease that has material basis in abnormal immune responses. disease_ontology DOID:0060056 hypersensitivity reaction disease DOID:0060058 A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs. DOID:1033 DOID:353 ICD10CM:C85.9 MESH:D008223 NCI:C3208 NCI:C7065 SNOMEDCT_US_2016_03_01:115244002 SNOMEDCT_US_2016_03_01:118600007 SNOMEDCT_US_2016_03_01:134218000 SNOMEDCT_US_2016_03_01:188676008 SNOMEDCT_US_2016_03_01:188694002 SNOMEDCT_US_2016_03_01:188695001 SNOMEDCT_US_2016_03_01:188704004 SNOMEDCT_US_2016_03_01:189959002 SNOMEDCT_US_2016_03_01:189965002 SNOMEDCT_US_2016_03_01:21964009 SNOMEDCT_US_2016_03_01:269627002 SNOMEDCT_US_2016_03_01:414628006 UMLS_CUI:C0024299 UMLS_CUI:C0598798 lymphoid cancer disease_ontology DOID:0060058 lymphoma DOID:0060060 A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma. OMIM:605027 disease_ontology DOID:0060060 OMIM mapping confirmed by DO. [LS]. non-Hodgkin lymphoma DOID:0060061 A non-Hodgkin's lymphoma that has material basis in a mutation of T cells. MESH:D016410 cutaneous T-cell lymphoma disease_ontology DOID:0060061 cutaneous T cell lymphoma DOID:0060064 ASAT disease_ontology DOID:0060064 OMIM mapping confirmed by DO. [LS]. sideroblastic anemia with spinocerebellar ataxia DOID:0060067 A mitochondrial metabolism disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction. OMIM:557000 Pearson Marrow-Pancreas Syndrome disease_ontology DOID:0060067 OMIM mapping confirmed by DO. [LS]. Pearson syndrome DOID:0060071 A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer. lschriml 2011-05-11T12:18:41Z disease_ontology DOID:0060071 pre-malignant neoplasm DOID:0060072 A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize. lschriml 2011-05-11T12:18:41Z disease_ontology DOID:0060072 benign neoplasm DOID:0060073 An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue. lschriml 2011-05-11T01:05:14Z disease_ontology DOID:0060073 lymphatic system cancer DOID:0060074 lschriml 2011-06-08T12:19:28Z disease_ontology DOID:0060074 ductal carcinoma in situ DOID:0060075 lschriml 2011-06-08T12:23:02Z disease_ontology DOID:0060075 estrogen-receptor positive breast cancer DOID:0060082 lschriml 2011-06-08T01:02:29Z disease_ontology DOID:0060082 breast benign neoplasm DOID:0060083 An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system. lschriml 2011-06-08T01:11:18Z disease_ontology DOID:0060083 immune system cancer DOID:0060084 A benign neoplasm that is classified by the type of cell or tissue from which it is derived. lschriml 2011-07-14T11:59:48Z disease_ontology DOID:0060084 cell type benign neoplasm DOID:0060085 A benign neoplasm that is classified by the organ system from which it is arising from. lschriml 2011-07-14T12:12:23Z disease_ontology DOID:0060085 organ system benign neoplasm DOID:0060086 lschriml 2011-07-14T12:20:52Z disease_ontology DOID:0060086 female reproductive organ benign neoplasm DOID:0060087 lschriml 2011-07-14T12:20:52Z disease_ontology DOID:0060087 male reproductive organ benign neoplasm DOID:0060089 An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. lschriml 2011-07-14T01:45:15Z disease_ontology DOID:0060089 endocrine organ benign neoplasm DOID:0060090 lschriml 2011-07-14T01:45:15Z disease_ontology DOID:0060090 central nervous system organ benign neoplasm DOID:0060091 An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system. lschriml 2011-07-14T01:45:15Z disease_ontology DOID:0060091 cardiovascular organ benign neoplasm DOID:0060094 A connective tissue benign neoplasm that is located_in bone. lschriml 2011-07-15T01:34:59Z disease_ontology DOID:0060094 bone benign neoplasm DOID:0060095 lschriml 2011-07-15T01:42:11Z DOID:0060113 disease_ontology DOID:0060095 uterine benign neoplasm DOID:0060097 An organ system benign neoplam that is located_in the thoracic cavity. lschriml 2011-07-15T01:55:57Z disease_ontology DOID:0060097 thoracic benign neoplasm DOID:0060099 An organ system benign neoplasm that is located_in the muscular and skeletal organs. lschriml 2011-07-15T02:28:52Z disease_ontology DOID:0060099 musculoskeletal system benign neoplasm DOID:0060100 An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs. lschriml 2011-07-15T02:30:51Z DOID:0060124 skeletal system cancer disease_ontology DOID:0060100 musculoskeletal system cancer DOID:0060101 A cell type benign neoplasm that has_material_basis_in glial cells. lschriml 2011-07-19T01:27:04Z disease_ontology DOID:0060101 benign glioma DOID:0060109 lschriml 2011-07-25T11:50:50Z disease_ontology DOID:0060109 vulvar benign neoplasm DOID:0060115 An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system. lschriml 2011-07-25T12:47:43Z disease_ontology DOID:0060115 nervous system benign neoplasm DOID:0060116 A nervous system cancer that is located_in the sensory system. lschriml 2011-07-25T01:51:56Z disease_ontology DOID:0060116 sensory system cancer DOID:0060118 A disease of anatomical entity that is located_in the thoracic cavity. lschriml 2011-07-25T02:23:47Z disease_ontology DOID:0060118 thoracic disease DOID:0060119 A gastrointestinal system cancer that is located_in the pharynx. lschriml 2011-07-27T01:26:34Z MESH:D010610 NCI:C3325 SNOMEDCT_US_2016_03_01:126685009 SNOMEDCT_US_2016_03_01:95001001 UMLS_CUI:C0031347 pharyngeal neoplasm pharynx neoplasm disease_ontology pharyngeal cancer DOID:0060119 pharynx cancer DOID:0060121 An organ system benign neoplasm located_in the integumentary system organs. lschriml 2011-07-27T01:49:44Z disease_ontology DOID:0060121 integumentary system benign neoplasm DOID:0060122 An organ system cancer that is located_in the skin, hair and nails. lschriml 2011-07-27T02:31:34Z disease_ontology DOID:0060122 integumentary system cancer DOID:0060123 A musculoskeletal system benign neoplasm that is located_in connective tissue. lschriml 2011-07-27T02:35:57Z DOID:177 MESH:D012983 NCI:C3377 SNOMEDCT_US_2016_03_01:126600002 SNOMEDCT_US_2016_03_01:387837005 UMLS_CUI:C0037579 neoplasm of soft tissue neoplasm of soft tissues soft tissue benign neoplasm tumor of the soft tissue disease_ontology DOID:0060123 connective tissue benign neoplasm DOID:0060131 An agnosia that is a deficiency in understanding, processing, or describing emotions. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060131 alexithymia DOID:0060135 An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060135 apraxia DOID:0060140 An agnosia that is a loss of the ability to perceive any auditory information but whose hearing is intact. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060140 cortical deafness DOID:0060142 An agnosia that is a loss of the ability to perceive a whole object while perceiving only parts of details. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060142 form agnosia DOID:0060145 An agnosia that is a loss of the ability to perceive and process pain. lschriml 2011-08-22T12:04:56Z analgesia disease_ontology DOID:0060145 pain agnosia DOID:0060151 An agnosia that is a loss of the ability to recognize or identify objects by touch alone. lschriml 2011-08-22T12:04:56Z disease_ontology DOID:0060151 tactile agnosia DOID:0060158 A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption. lschriml 2011-08-24T02:53:03Z disease_ontology DOID:0060158 acquired metabolic disease DOID:0060159 An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids. lschriml 2011-08-26T11:17:14Z organic acid metabolism disorder organic aciduria disease_ontology DOID:0060159 organic acidemia DOID:0060161 A spinal muscular dystrophy that has_material_basis_in an X-linked recessive expansion of CAG triplet repeats (glutamine) in exon 1 of AR gene encoding the androgen receptor. lschriml 2011-08-29T01:31:03Z MESH:D055534 NCI:C85233 OMIM:313200 SNOMEDCT_US_2016_03_01:230253001 UMLS_CUI:C1839259 Kennedy disease SBMA Spinobulbar Muscular Atrophy X-Linked Bulbo-Spinal Atrophy X-linked Spinal and Bulbar Muscular Atrophy spinal bulbar muscular atrophy disease_ontology DOID:0060161 Kennedy's disease DOID:0060162 An autosomal dominant cerebellar ataxia that has_material_basis_in expansion of CAG triplet repeats (glutamine) encoding a polyglutamine tract in the atrophin-1 protein. lschriml 2011-08-29T01:41:48Z MESH:D020191 NCI:C122653 NCI:C7636 OMIM:125370 SNOMEDCT_US_2016_03_01:192844008 SNOMEDCT_US_2016_03_01:267581004 SNOMEDCT_US_2016_03_01:68116008 SNOMEDCT_US_2016_03_01:702422004 SNOMEDCT_US_2016_03_01:89480000 UMLS_CUI:C0751776 UMLS_CUI:C0751777 UMLS_CUI:C0751778 UMLS_CUI:C0751779 UMLS_CUI:C0751780 UMLS_CUI:C0751781 UMLS_CUI:C0751782 DRPLA Haw River Syndrome Naito-Oyanagi disease disease_ontology DOID:0060162 dentatorubral-pallidoluysian atrophy DOID:0060163 A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image). lschriml 2011-09-07T01:38:34Z body dysmorphia dysmorphic syndrome dysmorphophobia disease_ontology DOID:0060163 body dysmorphic disorder DOID:0060164 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress. lschriml 2011-09-07T01:42:46Z disease_ontology DOID:0060164 pain disorder DOID:0060165 A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior. lschriml 2011-09-07T02:46:02Z disease_ontology DOID:0060165 Kleine-Levin syndrome DOID:0060167 A mental depression that involves presentation of depressive symptoms only during a specific season of the year. lschriml 2011-09-09T02:53:18Z winter depression disease_ontology DOID:0060167 seasonal affective disorder DOID:0060169 An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months. lschriml 2011-10-28T02:55:02Z OMIM:601764 OMIM:605751 OMIM:607745 OMIM:612627 ORDO:306 BFIC BFIE benign familial infantile convulsion benign familial infantile seizures disease_ontology DOID:0060169 Xref MGI. benign familial infantile epilepsy DOID:0060172 An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures. lschriml 2011-11-08T10:42:18Z disease_ontology DOID:0060172 juvenile absence epilepsy DOID:0060173 An autosomal dominant disease that is characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form that has_material_basis_in mutations in a transcript variant of CACNA1C on chromosome 12p13.33. lschriml 2011-11-08T12:52:33Z DOID:0110649 ICD10CM:G72.3 OMIM:601005 ORDO:65283 ORDO:768 disease_ontology DOID:0060173 Timothy syndrome DOID:0060175 A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid. lschriml 2011-11-08T02:02:12Z 4-hydroxybutyric aciduria SSADH gamma-hydroxybutyric aciduria disease_ontology DOID:0060175 succinic semialdehyde dehydrogenase deficiency DOID:0060176 An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway. lschriml 2011-11-08T02:02:12Z disease_ontology DOID:0060176 gamma-amino butyric acid metabolism disorder DOID:0060178 A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness. lschriml 2011-11-08T02:54:32Z ICD10CM:G43.8 ICD9CM:346.8 OMIM:141500 OMIM:300125 OMIM:602481 OMIM:607516 OMIM:609634 ORDO:569 SNOMEDCT_US_2016_03_01:193037008 SNOMEDCT_US_2016_03_01:193040008 SNOMEDCT_US_2016_03_01:194493009 UMLS_CUI:C0477373 disease_ontology DOID:0060178 Xref MGI. familial hemiplegic migraine DOID:0060180 An inflammatory bowel disease that involves inflammation located_in colon. emitraka 2014-09-12T14:31:45Z EFO:0003872 ICD10CM:K52.9 MESH:D003092 NCI:C26723 OMIM:191390 SNOMEDCT:64226004 SNOMEDCT_US_2016_03_01:64226004 UMLS_CUI:C0009319 disease_ontology DOID:0060180 colitis DOID:0060181 A colitis caused_by inadequate blood supply to the colon. emitraka 2014-09-12T14:36:51Z ICD10CM:K55.9 MESH:D017091 SNOMEDCT:30588004 SNOMEDCT_US_2016_03_01:30588004 UMLS_CUI:C0162529 disease_ontology DOID:0060181 ischemic colitis DOID:0060182 A colitis that can only be diagnosed_by the examination of colon tissue under a microscope. emitraka 2014-09-12T14:49:18Z MESH:D046728 NCI:C38504 ORDO:58220 SNOMEDCT:235753003 SNOMEDCT_US_2016_03_01:235753003 UMLS_CUI:C0400821 disease_ontology DOID:0060182 microscopic colitis DOID:0060184 A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria). emitraka 2014-09-12T14:58:50Z ICD10CM:K52.89 MESH:D046730 MedDRA:10025268 NCI:C27147 ORDO:65279 SNOMEDCT_US_2016_03_01:31437008 UMLS_CUI:C0400822 disease_ontology DOID:0060184 The peak incidence of lymphocytic colitis is in persons over age 50; the disease affects women and men equally. lymphocytic colitis DOID:0060185 A colitis characterized by an overgrowth of Clostridium difficile bacteria. emitraka 2014-09-12T15:01:17Z ICD10CM:A04.7 MESH:D004761 MedDRA:10009657 SNOMEDCT:423590009 SNOMEDCT_US_2016_03_01:155783000 SNOMEDCT_US_2016_03_01:197019008 SNOMEDCT_US_2016_03_01:197033008 SNOMEDCT_US_2016_03_01:197124009 SNOMEDCT_US_2016_03_01:235752008 SNOMEDCT_US_2016_03_01:266525002 SNOMEDCT_US_2016_03_01:397683000 SNOMEDCT_US_2016_03_01:397696004 SNOMEDCT_US_2016_03_01:51180003 UMLS_CUI:C0014358 UMLS_CUI:C0085819 UMLS_CUI:C1257843 UMLS_CUI:C1257844 UMLS_CUI:C1257845 Pseudomembranous colitis disease_ontology DOID:0060185 Clostridium difficile colitis DOID:0060189 An inflammatory bowel disease characterized by inflammation located_in ileum, has_symptom diarrhea, has_symptom abdominal pain, often in the right lower quadrant, has_symptom weight loss. emitraka 2014-09-15T11:40:07Z CSP:1248-5305 ICD10CM:K52.9 MESH:D007079 MedDRA:10021312 NCI:C84782 NDFRT:N0000001662 SNOMEDCT:52457000 SNOMEDCT_US_2016_03_01:52457000 UMLS_CUI:C0020877 Crohn's ileitis disease_ontology DOID:0060189 ileitis DOID:0060193 The most common type of familial ALS that has material basis in mutation in the SOD1 gene on chromosome 21. emitraka 2014-09-16T13:04:32Z ICD10CM:G12.2 OMIM:105400 ALS1 amyotrophic lateral sclerosis 1 disease_ontology DOID:0060193 amyotrophic lateral sclerosis type 1 DOID:0060195 An amyotrophic lateral sclerosis that has material basis in mutation in loci on chromosome 18. emitraka 2014-09-16T13:18:38Z OMIM:606640 amyotrophic lateral sclerosis 3 disease_ontology ALS3 DOID:0060195 amyotrophic lateral sclerosis type 3 DOID:0060196 An amyotrophic lateral sclerosis with juvenile onset that has material basis in mutation in the SETX gene on chromosome 9. emitraka 2014-09-16T13:49:59Z ICD10CM:G12.2 OMIM:602433 ORDO:357043 ALS 4 amyotrophic lateral sclerosis 4 amyotrophic lateral sclerosis 4, juvenile dHMN with upper motor neuron signs distal hereditary motor neuropathy with pyramidal features distal hereditary motor neuropathy with upper motor neuron signs disease_ontology DOID:0060196 amyotrophic lateral sclerosis type 4 DOID:0060200 An amyotrophic lateral sclerosis that has material basis in mutation in the ANG gene on chromosome 14. emitraka 2014-09-16T14:33:09Z OMIM:611895 ALS9 amyotrophic lateral sclerosis 9 disease_ontology DOID:0060200 amyotrophic lateral sclerosis type 9 DOID:0060220 An urticaria induced by external physical influences. emitraka 2014-11-21T15:51:38Z disease_ontology DOID:0060220 WD correction. physical urticaria DOID:0060221 A syndrome characterized by the presence of multiple enchondromas (benign growths of cartilage) associated with multiple hemangiomas. emitraka 2014-11-26T11:16:24Z ICD10CM:Q78.4 OMIM:614569 ORDO:163634 disease_ontology DOID:0060221 WD former synonym. Maffucci syndrome DOID:0060224 A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain. emitraka 2015-01-16T14:55:21Z HP:0005110 ICD10CM:I48 ICD9CM:427.31 MESH:D001281 NCI:C50466 SNOMEDCT_US_2016_03_01:155364009 SNOMEDCT_US_2016_03_01:266306001 SNOMEDCT_US_2016_03_01:49436004 UMLS_CUI:C0004238 A-fib disease_ontology DOID:0060224 atrial fibrillation DOID:0060229 A syndrome characterized by distinctive facial features including hypertelorism, large eyelid openings, ptosis, high-arched eyebrows, a broad nasal bridge and tip of the nose, a long space between the nose and the upper lip, full cheeks and a pointed chin; structural abnormalities of the brain might also be present. emitraka 2015-01-16T16:52:25Z ICD10CM:Q87.0 OMIM:243310 OMIM:614583 disease_ontology DOID:0060229 Xref MGI. Baraitser-Winter syndrome DOID:0060230 A basal ganglia disease characterized by the presence of abnormal calcium deposits of unknown cause in the brain; has symptom dementia, psychosis, mood swings and loss of acquired motor skills. emitraka 2015-01-22T13:09:08Z HP:0002135 MESH:C536275 OMIM:114100 OMIM:213600 OMIM:606656 OMIM:615007 OMIM:615483 SNOMEDCT_US_2016_03_01:110997000 UMLS_CUI:C0393590 Fahr disease disease_ontology DOID:0060230 NT MGI. basal ganglia calcification DOID:0060233 A syndrome characterized by unusually sparse, brittle, curly hair, macrocephaly, a prominent forehead and bi-temporal narrowing, intellectual disability, failure to thrive, congenital heart defects, short stature and skin abnormalities; it is that has material basis in mutation in the BRAF, MAP2K1, MAP2kK2 and KRAS genes. emitraka 2015-01-23T15:37:07Z ICD10CM:Q87.8 OMIM:115150 OMIM:615278 OMIM:615279 OMIM:615280 ORDO:1340 CFC syndrome cardio-facial-cutaneous syndrome disease_ontology DOID:0060233 NT MGI. cardiofaciocutaneous syndrome DOID:0060237 An autosomal recessive disease characterized by severe intellectual disability, microcephaly, congenital cataract, microcornea, microphthalmia, agenesis or hypoplasia of the corpus callosum and hypogenitalism. emitraka 2015-01-27T14:32:30Z MESH:C536681 OMIM:PS600118 ORDO:2510 UMLS_CUI:C1838625 WARBM Warburg-Sjo-Fledelius syndrome micro syndrome disease_ontology DOID:0060237 NT MGI. Warburg micro syndrome DOID:0060242 A syndactyly characterized by an increased number of digits; often a result of a mutation in the HOX D13 gene. emitraka 2015-01-27T16:57:56Z MESH:C538153 NCI:C75003 OMIM:186000 OMIM:608180 OMIM:610234 ORDO:295195 UMLS_CUI:C2699746 syndactyly type 2 disease_ontology DOID:0060242 NT MGI. synpolydactyly DOID:0060243 An articulation disorder characterized by involuntary sound repetition and disruption or blocking of speech. emitraka 2015-01-28T16:04:54Z ICD10CM:F80.81 MESH:D013342 NCI:C35043 OMIM:184450 OMIM:609261 OMIM:614655 OMIM:614668 SNOMEDCT_US_2016_03_01:154935003 SNOMEDCT_US_2016_03_01:191987007 SNOMEDCT_US_2016_03_01:192632007 SNOMEDCT_US_2016_03_01:229631007 SNOMEDCT_US_2016_03_01:231512003 SNOMEDCT_US_2016_03_01:231513008 SNOMEDCT_US_2016_03_01:29916003 SNOMEDCT_US_2016_03_01:39423001 SNOMEDCT_US_2016_03_01:416163003 UMLS_CUI:C0038131 UMLS_CUI:C0038506 UMLS_CUI:C0454542 UMLS_CUI:C0751527 UMLS_CUI:C0751528 UMLS_CUI:C0751529 UMLS_CUI:C3489627 familial persistent stuttering stammering disease_ontology DOID:0060243 NT MGI. stuttering DOID:0060249 A bone structure disease characterized by an appreciable lateral deviation in the normally straight vertical line of the spine. emitraka 2015-01-29T15:44:16Z HP:0002650 ICD10CM:M41 ICD10CM:M41.9 MESH:D012600 NCI:C78603 SNOMEDCT:20944008 SNOMEDCT:298382003 SNOMEDCT_US_2016_03_01:298382003 SNOMEDCT_US_2016_03_01:36773001 UMLS_CUI:C0036439 disease_ontology DOID:0060249 NT MGI add. scoliosis DOID:0060250 A scoliosis with no known cause. emitraka 2015-01-29T15:52:18Z OMIM:181800 OMIM:607354 OMIM:608765 OMIM:612238 OMIM:612239 disease_ontology DOID:0060250 NT MGI. idiopathic scoliosis DOID:0060254 A syndrome characterized by mild to moderate short stature due to growth delays after birth, distinctive craniofacial abnormalities, skeletal malformations and genital abnormalities. emitraka 2015-01-29T16:42:52Z ICD10CM:Q87.1 MESH:C562492 NCI:C85048 ORDO:97360 SNOMEDCT_US_2016_03_01:76520005 UMLS_CUI:C0265205 Robinow dwarfism acral dysostosis with facial and genital abnormalities fetal face syndrome disease_ontology DOID:0060254 NT MGI. Robinow syndrome DOID:0060255 A muscle tissue disease characterized by muscles unusually sensitive to movement or pressure; the proximal muscles are most affected, especially the thighs. emitraka 2015-01-29T16:51:43Z OMIM:600332 OMIM:606072 ORDO:97238 UMLS_CUI:C1853698 disease_ontology DOID:0060255 NT MGI. rippling muscle disease 2 DOID:0060256 A pigmentation disease characterized by a reticulate pattern of abnormally dark skin coloring, particularly in the body's folds and creases. emitraka 2015-01-30T11:04:57Z MESH:C562924 OMIM:179850 OMIM:615327 OMIM:615674 OMIM:615696 ORDO:79145 SNOMEDCT_US_2016_03_01:239133004 UMLS_CUI:C0406811 UMLS_CUI:C3714534 dark dot disease reticular pigment anomaly of flexures disease_ontology DOID:0060256 NT MGI. Dowling-Degos disease DOID:0060259 A physical disorder characterized by pancreatic fibrosis, renal dysplasia and hepatic dysgenesis; it is usual fatal soon after birth. emitraka 2015-01-30T16:33:37Z OMIM:208540 OMIM:615415 ORDO:294415 Ivemark's syndrome disease_ontology DOID:0060259 renal-hepatic-pancreatic dysplasia DOID:0060260 An eye disease characterized by the drooping or falling of the upper or lower eyelid. emitraka 2015-01-30T16:46:53Z HP:0000508 ICD10CM:H02.4 ICD10CM:H02.40 ICD10CM:H02.409 ICD9CM:374.3 ICD9CM:374.30 MESH:D001763 NCI:C27298 SNOMEDCT_US_2016_03_01:11934000 SNOMEDCT_US_2016_03_01:155179008 SNOMEDCT_US_2016_03_01:193942002 SNOMEDCT_US_2016_03_01:193943007 SNOMEDCT_US_2016_03_01:193945000 SNOMEDCT_US_2016_03_01:204197004 UMLS_CUI:C0005745 blepharoptosis drooping eyelid disease_ontology DOID:0060260 NT MGI add. ptosis DOID:0060262 A gastrointestinal system disease that is located_in the gallbladder. emitraka 2015-02-02T15:48:08Z DOID:0000000 ICD10CM:K82.9 ICD9CM:575.9 MESH:D005705 NCI:C34631 OMIM:609918 OMIM:609919 OMIM:611465 SNOMEDCT_US_2016_03_01:155807008 SNOMEDCT_US_2016_03_01:155826000 SNOMEDCT_US_2016_03_01:155829007 SNOMEDCT_US_2016_03_01:266535008 SNOMEDCT_US_2016_03_01:266542008 SNOMEDCT_US_2016_03_01:266543003 SNOMEDCT_US_2016_03_01:39621005 UMLS_CUI:C0016977 disease_ontology DOID:0060262 Xref MGI. gallbladder disease DOID:0060263 emitraka 2015-02-04T14:12:00Z HP:0002132 ICD10CM:Q04.6 MESH:D065708 OMIM:175780 OMIM:614483 ORDO:2940 SNOMEDCT_US_2016_03_01:204071008 SNOMEDCT_US_2016_03_01:38353004 SNOMEDCT_US_2016_03_01:698837003 UMLS_CUI:C0302892 UMLS_CUI:C1867983 UMLS_CUI:C3698507 disease_ontology DOID:0060263 NT MGI. porencephaly DOID:0060264 emitraka 2015-02-04T14:23:25Z MESH:C580383 SNOMEDCT_US_2016_03_01:45163000 UMLS_CUI:C0266468 PCH disease_ontology DOID:0060264 NT MGI add. pontocerebellar hypoplasia DOID:0060281 An epilepsy characterized by seizures triggered by visual stimuli that form patterns in space or time, such as flashing lights. emitraka 2015-02-04T16:15:55Z ICD10CM:G40.8 OMIM:132100 OMIM:609572 OMIM:609573 ORDO:166409 photogenic epilepsy photoparoxysmal response disease_ontology DOID:0060281 NT MGI. photosensitive epilepsy DOID:0060282 emitraka 2015-02-04T16:21:06Z MESH:D054514 OMIM:221900 OMIM:611308 ORDO:91495 SNOMEDCT_US_2016_03_01:314270008 SNOMEDCT_US_2016_03_01:44647001 SNOMEDCT_US_2016_03_01:69927002 UMLS_CUI:C0266568 disease_ontology DOID:0060282 NT MGI. persistent hyperplastic primary vitreous DOID:0060287 emitraka 2015-02-04T17:04:28Z HP:0007720 ICD10CM:Q13.4 OMIM:121400 OMIM:217300 ORDO:53691 flat cornea disease_ontology DOID:0060287 NT MGI. cornea plana DOID:0060288 emitraka 2015-02-05T09:58:47Z MESH:C537746 MESH:C567664 OMIM:164745 OMIM:258315 ORDO:2733 UMLS_CUI:C1850318 UMLS_CUI:C2750355 disease_ontology DOID:0060288 NT MGI. omodysplasia DOID:0060305 A corneal disease characterized by a bilaterally enlarged corneal diameter without an increase in intraocular pressure. It has material basis in mutation in the CHRDL1 gene. emitraka 2015-02-10T12:29:54Z HP:0007660 MESH:C562829 OMIM:249300 OMIM:309300 ORDO:91489 SNOMEDCT_US_2016_03_01:204118005 SNOMEDCT_US_2016_03_01:204119002 SNOMEDCT_US_2016_03_01:268158009 SNOMEDCT_US_2016_03_01:388840007 SNOMEDCT_US_2016_03_01:39978004 UMLS_CUI:C0344530 anterior megalophthalmos congenital anterior megalophthalmia disease_ontology DOID:0060305 NT MGI. megalocornea DOID:0060308 A non-syndromic intellectual disability characterized by an autosomal recessive inheritance pattern. emitraka 2015-02-11T10:32:11Z OMIM:249500 OMIM:607417 OMIM:608443 OMIM:611090 OMIM:611091 OMIM:611092 OMIM:611093 OMIM:611095 OMIM:611096 OMIM:611097 OMIM:611107 OMIM:614020 OMIM:614208 OMIM:614249 OMIM:614329 OMIM:614333 OMIM:614340 OMIM:614341 OMIM:614342 OMIM:614343 OMIM:614344 OMIM:614345 OMIM:614346 OMIM:614347 OMIM:614499 OMIM:615493 OMIM:615516 OMIM:615541 OMIM:615599 OMIM:615637 OMIM:615802 OMIM:615817 OMIM:615942 ORDO:88616 autosomal recessive mental retardation autosomal recessive non-syndromic mental retardation disease_ontology DOID:0060308 NT MGI. autosomal recessive non-syndromic intellectual disability DOID:0060309 A syndromic intellectual characterized by an X-linked inheritance pattern. emitraka 2015-02-11T16:14:46Z OMIM:PS309510 syndromic X-linked mental retardation disease_ontology DOID:0060309 NT MGI. syndromic X-linked intellectual disability DOID:0060313 A tracheal disease characterized by flaccidity of the tracheal support cartilage. emitraka 2015-02-20T16:02:03Z HP:0002779 ICD10CM:Q32.0 MESH:C557675 ORDO:95430 SNOMEDCT_US_2016_03_01:95467005 UMLS_CUI:C0392109 congenital tracheomalacia disease_ontology DOID:0060313 PRISM. tracheomalacia DOID:0060314 A lymph node disease characterized by enlarged, non-painful lymph nodes occurring for more than three to six months for which no other reason can be found. emitraka 2015-02-23T14:33:26Z HP:0008940 PGL disease_ontology DOID:0060314 PRISM. persistent generalized lymphadenopathy DOID:0060318 An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by a translocation between chromosomes 15 and 17. emitraka 2015-02-24T16:50:50Z ICD10CM:C92.4 ICD10CM:C92.40 MESH:D015473 NCI:C3182 OMIM:612376 ORDO:520 SNOMEDCT_US_2016_03_01:110004001 SNOMEDCT_US_2016_03_01:28950004 UMLS_CUI:C0023487 APL acute myeloblastic leukemia type 3 acute myeloid leukemia M3 disease_ontology DOID:0060318 acute promyelocytic leukemia DOID:0060319 A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all. emitraka 2015-02-25T15:12:30Z ICD10CM:I46 ICD9CM:427.5 MESH:D006323 NCI:C50479 NCI:C50483 SNOMEDCT_US_2016_03_01:155372006 SNOMEDCT_US_2016_03_01:195085006 SNOMEDCT_US_2016_03_01:195090009 SNOMEDCT_US_2016_03_01:233926006 SNOMEDCT_US_2016_03_01:251189000 SNOMEDCT_US_2016_03_01:30298009 SNOMEDCT_US_2016_03_01:309810002 SNOMEDCT_US_2016_03_01:397829000 SNOMEDCT_US_2016_03_01:397912004 SNOMEDCT_US_2016_03_01:410429000 SNOMEDCT_US_2016_03_01:410430005 UMLS_CUI:C0018790 UMLS_CUI:C0600228 cardiopulmonary arrest circulatory arrest disease_ontology DOID:0060319 cardiac arrest DOID:0060320 An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal. emitraka 2015-02-25T15:54:50Z HP:0000023 ICD10CM:K40 ICD10CM:K40.90 ICD9CM:550 MESH:D006552 NCI:C34690 NCI:C34691 NCI:C34692 SNOMEDCT_US_2016_03_01:155738001 SNOMEDCT_US_2016_03_01:155741005 SNOMEDCT_US_2016_03_01:155744002 SNOMEDCT_US_2016_03_01:196800008 SNOMEDCT_US_2016_03_01:196822001 SNOMEDCT_US_2016_03_01:196827007 SNOMEDCT_US_2016_03_01:196828002 SNOMEDCT_US_2016_03_01:261478001 SNOMEDCT_US_2016_03_01:261480007 SNOMEDCT_US_2016_03_01:266440002 SNOMEDCT_US_2016_03_01:266508004 SNOMEDCT_US_2016_03_01:266509007 SNOMEDCT_US_2016_03_01:266510002 SNOMEDCT_US_2016_03_01:286968003 SNOMEDCT_US_2016_03_01:286969006 SNOMEDCT_US_2016_03_01:396232000 SNOMEDCT_US_2016_03_01:44297005 SNOMEDCT_US_2016_03_01:65626001 SNOMEDCT_US_2016_03_01:73147001 UMLS_CUI:C0019294 UMLS_CUI:C0019295 UMLS_CUI:C0019296 disease_ontology DOID:0060320 inguinal hernia DOID:0060327 A physical disorder characterized by a defect in the development of the abdominal wall muscles, resulting in the intestines, liver and other organs to remain outside of the abdomen in a sac. emitraka 2015-02-25T17:54:05Z HP:0001539 ICD10CM:Q79.2 ICD9CM:756.72 MESH:D006554 NCI:C98997 OMIM:164750 SNOMEDCT_US_2016_03_01:157007005 SNOMEDCT_US_2016_03_01:18735004 SNOMEDCT_US_2016_03_01:196854005 SNOMEDCT_US_2016_03_01:196872004 SNOMEDCT_US_2016_03_01:205516007 SNOMEDCT_US_2016_03_01:271017007 SNOMEDCT_US_2016_03_01:396347007 SNOMEDCT_US_2016_03_01:49324006 SNOMEDCT_US_2016_03_01:5867007 UMLS_CUI:C0795690 UMLS_CUI:C1306503 omphalocoele disease_ontology DOID:0060327 omphalocele DOID:0060329 A female reproductive system disease characterized by the implantation of the embryo outside the uterine cavity. elvira 2015-02-25T19:27:50Z ICD10CM:O00 ICD10CM:O00.9 ICD9CM:633 ICD9CM:633.9 MESH:D011271 NCI:C34945 SNOMEDCT_US_2016_03_01:156080003 SNOMEDCT_US_2016_03_01:156083001 SNOMEDCT_US_2016_03_01:198630007 SNOMEDCT_US_2016_03_01:34801009 UMLS_CUI:C0032987 eccyesis disease_ontology DOID:0060329 ectopic pregnancy DOID:0060340 A genetic disease associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia. emitraka 2015-05-21T10:41:29Z disease_ontology DOID:0060340 ciliopathy DOID:0060344 An acrodermatitis characterized by a chronically progressive course, leading to widespread atrophy of the skin. It is a clinical manifestation of Lyme borreliosis. emitraka 2015-05-28T14:45:56Z DERMO:0002165 ICD9CM:701.8 SNOMEDCT_US_2016_03_01:201079006 SNOMEDCT_US_2016_03_01:201088002 UMLS_CUI:C0029805 Herxheimer disease primary diffuse atrophy disease_ontology DOID:0060344 acrodermatitis chronica atrophicans DOID:0060345 A bartonellosis that has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella quintana. The disease is characterized by the proliferation of blood vessels, resulting in them forming tumour-like masses in the skin and other organs. emitraka 2015-05-28T16:26:12Z MESH:D016917 NCI:C3477 SNOMEDCT_US_2016_03_01:58213005 UMLS_CUI:C0085434 disease_ontology DOID:0060345 bacillary angiomatosis DOID:0060352 A syndrome characterized by childhood hypotonia, a distinctive facial appearance, speech impediments and developmental disability, as well as epilepsy, congenital and urogenetic defects, microcephaly, corpulence, and psychiatric disorders. It is caused either by a microdeletion in the chromosome region 9q34.3 or by a point mutation in the EHMT1 gene located in that region. elvira 2015-07-14T16:49:09Z MESH:C563043 OMIM:610253 ORDO:261494 UMLS_CUI:C0795833 9q subtelomeric deletion syndrome 9q-syndrome 9q34 deletion syndrome disease_ontology DOID:0060352 Kleefstra syndrome DOID:0060354 A blood platelet disease characterized by thrombocytopathy, thrombocytopenia, mild anemia, asplenia, tubular aggregate myopathy, miosis, headache, and ichthyosis. It has material basis in heterozygous mutation in the STM1 gene on chromosome 11p15. It has an autosomal dominant inheritance pattern. elvira 2015-07-16T16:30:32Z MESH:C566108 OMIM:185070 ORDO:3204 SNOMEDCT_US_2016_03_01:711407000 UMLS_CUI:C1861451 thrombocytopathy, asplenia and miosis disease_ontology DOID:0060354 Stormorken syndrome DOID:0060358 An inherited metabolic disorder characterized by the body's inability to break down proteins and fats to produce energy. It is a disorder of fatty acid, amino acid, and choline metabolism and has an autosomal recessive inheritance pattern. It has material basis in mutations in the ETFA, ETFB and ETFDH genes. It presents three clinical phenotypes: a neonatal-onset form with congenital anomalies (type I), a neonatal-onset form without congenital anomalies (type II), and a late-onset form (type III). The neonatal-onset forms are usually fatal. elvira 2015-08-20T16:23:47Z ICD10CM:E71.313 MESH:D054069 NCI:C84907 NCI:C99102 OMIM:231680 ORDO:26791 SNOMEDCT_US_2016_03_01:22886006 UMLS_CUI:C0268596 UMLS_CUI:C1856401 UMLS_CUI:C1856403 UMLS_CUI:C1856405 MAD deficiency MADD electron transfer flavoprotein deficiency electron transfer flavoprotein ubiquinone oxidoreductase deficiency glutaric acidemia type 2 glutaric aciduria type 2 disease_ontology DOID:0060358 multiple acyl-CoA dehydrogenase deficiency DOID:0060363 An inherited metabolic disorder characterized_by wide range of phenotypic variability; patients can have severe metabolic and CNS abnormalities, while others possess hyperglycerolemia and glyceroluria with no other apparent phenotype. It has material basis in mutation in the GK gene on chromosome Xp21. elvira 2015-09-17T15:45:20Z OMIM:307030 ORDO:408 SNOMEDCT_US_2016_03_01:297256008 UMLS_CUI:C0574108 disease_ontology DOID:0060363 glycerol kinase deficiency DOID:0060365 A syndrome characterized_by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids, and with alopecia. elvira 2015-09-17T16:20:00Z OMIM:616367 MFDA disease_ontology DOID:0060365 mandibulofacial dysostosis with alopecia DOID:0060366 A lymphatic system disease characterized by he presence of intestinal lymphangiectasia, mental retardation, and characteristic facial anomalies. It is inherited in an autosomal recessive pattern. Most individuals with Hennekam syndrome have characteristic facial abnormalities, such as a flat face with accompanying puffy eyelids and hypertelorism; the nasal bridge is typically flat and the ears are typically small. Congenital extremity and genital lymphedema is present in most patients. elvira 2015-09-17T16:36:59Z MESH:C537255 OMIM:235510 OMIM:616006 ORDO:2136 SNOMEDCT_US_2016_03_01:234146006 UMLS_CUI:C0340834 Hennekam lymphangiectasia-lymphedema syndrome lymphedem-lymphangiectasia-intellectual disability syndrome disease_ontology DOID:0060366 Hennekam syndrome DOID:0060372 A Parkinson's disease that has_material_basis_in mutation in the FBXO7 gene on chromosome 22q12.3. elvira 2015-09-17T17:13:37Z OMIM:260300 ORDO:171695 Parkinsonian-pyramidal syndrome pallidopyramidal syndrome disease_ontology DOID:0060372 autosomal recessive early-onset Parkinson disease 15 DOID:0060379 elvira 2015-09-21T15:24:28Z disease_ontology DOID:0060379 acrofacial dysostosis DOID:0060388 elvira 2015-09-28T15:48:41Z disease_ontology DOID:0060388 chromosomal deletion syndrome DOID:0060390 elvira 2015-09-28T16:08:42Z ICD10CM:Q93.5 MESH:C567182 OMIM:609625 ORDO:96148 chromosome 10q26 deletion syndrome distal monosomy 10q monosomy 10qter telomeric deletion 10q terminal chromosome 10q26 deletion syndrome disease_ontology DOID:0060390 distal 10q deletion syndrome DOID:0060391 elvira 2015-09-28T16:14:46Z ICD10CM:Q93.5 OMIM:613884 ORDO:1587 deletion 13q14 disease_ontology DOID:0060391 chromosome 13q14 deletion syndrome DOID:0060394 elvira 2015-09-28T16:23:21Z ICD10CM:Q93.5 MESH:C567439 OMIM:612001 ORDO:199318 15q13.3 microdeletion syndrome disease_ontology DOID:0060394 chromosome 15q13.3 microdeletion syndrome DOID:0060403 elvira 2015-09-28T16:52:05Z ICD10CM:Q85.0 OMIM:613675 ORDO:97685 17q11 microdeletion syndrome NF1 microdeletion syndrome Van Asperen syndrome neurofibromatosis type 1 microdeletion syndrome disease_ontology DOID:0060403 chromosome 17q11.2 deletion syndrome, 1.4Mb DOID:0060407 elvira 2015-09-28T17:05:53Z ICD10CM:Q93.5 MESH:C536580 OMIM:601808 ORDO:1600 18q- syndrome deletion 18q monosomy 18q disease_ontology DOID:0060407 chromosome 18q deletion syndrome DOID:0060410 elvira 2015-09-28T17:14:10Z MESH:C535362 NCI:C74983 OMIM:607872 ORDO:1606 SNOMEDCT_US_2016_03_01:699306003 UMLS_CUI:C1842870 1p36 deletion syndrome deletion 1p36 monosomy 1p36 disease_ontology subtelomeric 1p36 deletion DOID:0060410 chromosome 1p36 deletion syndrome DOID:0060413 elvira 2015-09-28T17:28:28Z OMIM:611867 ORDO:261330 distal 22q11.2 microdeletion syndrome disease_ontology DOID:0060413 chromosome 22q11.2 deletion syndrome, distal DOID:0060415 elvira 2015-09-28T17:32:44Z ICD10CM:Q93.5 OMIM:612513 ORDO:261349 2p15p16.1 microdeletion syndrome disease_ontology 2p15-p16.1 microdeletion syndrome DOID:0060415 chromosome 2p16.1-p15 deletion syndrome DOID:0060417 elvira 2015-09-28T17:38:32Z ICD10CM:Q93.5 OMIM:613792 ORDO:1620 chromosome 3pter-P25 deletion syndrome distal monosomy 3p disease_ontology DOID:0060417 3p- syndrome DOID:0060420 elvira 2015-09-28T17:49:18Z OMIM:613509 ORDO:238750 4q21 microdeletion syndrome monosomy 4q21 disease_ontology DOID:0060420 chromosome 4q21 deletion syndrome DOID:0060422 elvira 2015-09-28T17:55:16Z ICD10CM:Q93.5 OMIM:612582 ORDO:96125 6p subtelomeric deletion syndrome 6p25 microdeletion syndrome distal monosomy 6p disease_ontology DOID:0060422 chromosome 6pter-p24 deletion syndrome DOID:0060427 elvira 2015-09-29T16:13:28Z ICD10CM:Q99.8 OMIM:300679 ORDO:261476 Xp21 microdeletion syndrome complex glycerol kinase deficiency monosomy Xp21 disease_ontology DOID:0060427 chromosome Xp21 deletion syndrome DOID:0060442 elvira 2015-10-16T16:39:25Z disease_ontology DOID:0060442 stromal dystrophy DOID:0060443 elvira 2015-10-16T16:39:25Z endothelial dystrophy disease_ontology DOID:0060443 corneal endothelial dystrophy DOID:0060446 elvira 2015-10-16T17:13:34Z ICD10CM:H18.5 MESH:C567587 OMIM:300779 ORDO:293621 XECD disease_ontology DOID:0060446 X-linked endothelial corneal dystrophy DOID:0060448 elvira 2015-10-16T17:20:34Z MESH:C563256 OMIM:121850 ORDO:98970 SNOMEDCT_US_2016_03_01:417183007 UMLS_CUI:C1562113 FCD Francois-Neetens speckled corneal dystrophy disease_ontology DOID:0060448 Fleck corneal dystrophy DOID:0060456 elvira 2015-10-16T18:01:14Z MESH:C535475 OMIM:121800 ORDO:98967 SNOMEDCT_US_2016_03_01:39662004 SNOMEDCT_US_2016_03_01:419395007 SNOMEDCT_US_2016_03_01:420212002 UMLS_CUI:C0271287 SCCD Schnyder crystalline corneal dystrophy corneal dystrophy crystalline of Schnyder crystalline stromal dystrophy hereditary crystalline stromal dystrophy of Schnyder disease_ontology DOID:0060456 Schnyder corneal dystrophy DOID:0060457 elvira 2015-10-16T18:05:26Z ICD10CM:H18.5 MESH:C562745 OMIM:122000 OMIM:609140 OMIM:609141 ORDO:98973 PPCD Schlichting dystrophy hereditary polymorphus posterior corneal dystrophy disease_ontology DOID:0060457 posterior polymorphous corneal dystrophy DOID:0060466 A gingival overgrowth characterized by benign, slowly progressive, nonhemorrhagic, fibrous enlargement of the oral masticatory mucosa. elvira 2015-11-04T16:47:21Z MESH:C562884 OMIM:135300 OMIM:605544 OMIM:609955 OMIM:611010 ORDO:2024 SNOMEDCT_US_2016_03_01:109620006 UMLS_CUI:C0399440 hereditary gingival fibromatosis hereditary gingival hyperplasia disease_ontology DOID:0060466 gingival fibromatosis DOID:0060467 elvira 2015-11-11T21:29:39Z ICD10CM:Q74.0 OMIM:143050 OMIM:236400 ORDO:3265 UMLS_CUI:C0431800 disease_ontology humero-radial fusion DOID:0060467 humeroradial synostosis DOID:0060473 A syndrome characterized by multiple congenital anomalies and mental retardation. Other characteristics include a peculiar facial gestalt, short stature, skeletal and visceral abnormalities, cardiac anomalies, and immunological defects. elvira 2015-11-18T16:21:35Z MESH:C537705 OMIM:147920 OMIM:300867 ORDO:2322 SNOMEDCT_US_2016_03_01:205805008 SNOMEDCT_US_2016_03_01:313426007 UMLS_CUI:C0796004 KMS Kabuki make up syndrome Niikawa-Kuroki syndrome disease_ontology DOID:0060473 Kabuki syndrome DOID:0060479 A syndrome characterized by exocrine pancreatic insufficiency, bone marrow failure and skeletal abnormalities. ICD10CM:D61.0 MESH:C537330 OMIM:260400 Shwachman syndrome Shwachman-Bodian-Diamond syndrome pancreatic insufficiency and bone marrow dysfunction Shwachman-Diamond syndrome DOID:0060481 A syndrome characterized by intellectual disability, specific facial gestalt and Hirschsprung's disease (HSCR). It has material basis in homozygous mutation in the KIAA1279 gene on chromosome 10q21.1. MESH:C537279 OMIM:609460 ORDO:66629 UMLS_CUI:C1836123 Goldberg-Shprintzen megacolon syndrome Goldberg-Shprintzen syndrome DOID:0060482 A syndrome characterized by microcornea, microphthalmia, anterior-segment dysgenesis, cataract, coloboma of various parts of the eye, abnormalities of the retinal pigment epithelium, and rod-cone dystrophy and a particular cleft ear lobule. ICD10CM:Q87.8 MESH:C567416 OMIM:612109 ORDO:157962 oculoauricular syndrome DOID:0060484 A syndrome characterize by seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance. It has material basis in homozygous or compound heterozygous mutation in the KCNJ10 gene on chromosome 1q23. MESH:C557674 OMIM:612780 ORDO:199343 UMLS_CUI:C2748572 SeSAME syndrome epilepsy, ataxia, sensorineural deafness and tubulopathy seizures, sensorineural deafness, ataxia, mental retardation and electrolyte imbalance EAST syndrome DOID:0060485 A syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows, medially flaring and sparse in the middle part, hypertelorism, deep set but large eyes, large and uplifted ear lobes, with a central depression, saddle nose with prominent rounded nasal tip, prominent columella, open mouth, with M-shaped upper lip, frequent smiling, and a prominent but narrow and triangular pointed chin), moderate-to-severe intellectual deficiency, epilepsy and variable congenital malformations including Hirschsprung disease, genitourinary anomalies (in particular hypospadias in males), congenital heart defects, agenesis of the corpus callosum and eye anomalies. It has material basis in de novo heterozygous mutation in the ZEB2 gene on chromosome 2q22. MESH:C536990 NCI:C74999 OMIM:235730 ORDO:2152 SNOMEDCT_US_2016_03_01:703535000 UMLS_CUI:C1856113 Hirschsprung disease mental retardation syndrome microcephaly, mental retardation, and distinct facial featrues, with or without Hirschprung disease Mowat-Wilson syndrome DOID:0060488 A syndrome characterized by intellectual disability and developmental delay, breathing problems, recurrent seizures (epilepsy), and distinctive facial features. It has material basis in heterozygous de novo mutations in the TCF4 gene in chromosome 18q21. MESH:C537403 OMIM:610954 ORDO:2896 SNOMEDCT_US_2016_03_01:702344008 UMLS_CUI:C1970431 Pitt-Hopkins syndrome DOID:0060495 A food allergy triggered by Crustacea or Mollusca. DOID:0060495 shellfish allergy DOID:0060532 A hypersensitivity reaction type I disease triggered by latex. DOID:0060532 latex allergy DOID:0060558 A syndrome characterized by congenital nonprogressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. ICD10CM:Q68.8 OMIM:PS253310 ORDO:294965 lethal congenital contracture syndrome DOID:0060611 OMIM:PS605552 DOID:0060611 abdominal obesity-metabolic syndrome DOID:0060668 A congenital nervous system abnormality characterized by failure of the anterior neuropore to close resulting in partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp. ICD10CM:00.0 OMIM:206500 ORDO:1048 DOID:0060668 anencephaly DOID:0060786 A leukodystrophy characterized by T2 hyperintensity and T1 iso- or hyperintensity of affected white matter in the central nervous system. OMIM:PS312080 HLD DOID:0060786 hypomyelinating leukodystrophy DOID:0060894 ORDO:391411 DOID:0060894 early-onset Parkinson disease DOID:0070003 A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from precursor cells called blast cells. disease_ontology DOID:0070003 blastoma DOID:0070004 A bone marrow cancer that is formed of any one of the bone marrow cells belonging to the granulocytic (neutrophil, eosinophil, basophil), monocytic/macrophage, erythroid, megakaryocytic and mast cell lineages. myeloma disease_ontology DOID:0070004 myeloid neoplasm DOID:0080000 A musculoskeletal system disease that affects the muscles. disease_ontology DOID:0080000 muscular disease DOID:0080001 A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. DOID:1290 ICD10CM:M89.9 MESH:D001847 SNOMEDCT_US_2016_03_01:156814002 SNOMEDCT_US_2016_03_01:203524000 SNOMEDCT_US_2016_03_01:268126004 SNOMEDCT_US_2016_03_01:274145000 SNOMEDCT_US_2016_03_01:308147009 SNOMEDCT_US_2016_03_01:76069003 UMLS_CUI:C0005940 disease_ontology skeletal disease DOID:0080001 bone disease DOID:0080005 A bone disease that results_in formation or resorption abnormalities located_in bone. disease_ontology DOID:0080005 bone remodeling disease DOID:0080006 A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage. disease_ontology DOID:0080006 bone development disease DOID:0080007 A bone structure disease that results_in change or damage of structure located_in bone. disease_ontology DOID:0080007 bone deterioration disease DOID:0080008 A bone disease that results_in an interruption of blood supply located_in bone. disease_ontology DOID:0080008 ischemic bone disease DOID:0080010 A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure. disease_ontology DOID:0080010 bone structure disease DOID:0080011 A bone remodeling disease that results in an abnormal decrease of bone density or mass. MESH:D001862 disease_ontology DOID:0080011 bone resorption disease DOID:0080014 A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes. disease_ontology DOID:0080014 chromosomal disease DOID:0080015 A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment. disease_ontology DOID:0080015 physical disorder DOID:0080016 disease_ontology DOID:0080016 spina bifida DOID:0080019 An osteochondrodysplasia that results_in thinning and the tendency to fracture located_in bone. OMIM:215050 Bakwin-Krida syndrome Pyle's disease Pyle-Cohn syndrome disease_ontology DOID:0080019 metaphyseal dysplasia DOID:0080031 A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue. disease_ontology DOID:0080031 fibrous dysplasia DOID:0080033 An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs. OMIM:122860 OMIM:123000 OMIM:218300 OMIM:218400 OMIM:614099 OMIM:614378 ORDO:1522 disease_ontology DOID:0080033 Xref MGI. craniometaphyseal dysplasia DOID:0080038 An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges. disease_ontology DOID:0080038 pycnodysostosis DOID:0080041 An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism. disease_ontology DOID:0080041 hypochondroplasia DOID:0080046 OMIM:108300 OMIM:184840 OMIM:604841 disease_ontology DOID:0080046 OMIM mapping confirmed by DO. [SN]. Stickler syndrome DOID:0080049 An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb Dwarfism. disease_ontology DOID:0080049 acromesomelic dysplasia DOID:0080053 An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face. OMIM:103580 Albright hereditary osteodystrophy pseudohypoparathyroidism type 1a disease_ontology DOID:0080053 Albright's hereditary osteodystrophy DOID:0080074 lschriml 2015-10-19T14:41:42Z OMIM:301410 OMIM:601634 disease_ontology DOID:0080074 neural tube defect DOID:0080079 lschriml 2015-11-09T15:13:08Z OMIM:161050 twenty-nail dystrophy disease_ontology DOID:0080079 nonsyndromic congenital nail disorder 1 DOID:0080108 A myopathy that is characterized by an increased urinary excretion of myoglobin. OMIM:160010 OMIM:268200 OMIM:550500 DOID:0080108 myoglobinuria DOID:0080109 A connective tissue benign neoplasm that is characterized by the development of benign tumors in the skin, striated muscles, bones, and in exceptional cases, visceral organs. OMIM:228550 OMIM:615293 ORDO:2591 infantile myofibromatosis DOID:0080110 A genetic disease that is characterized by permanently bent fingers (camptodactyly), short stature, rocker-bottom or club feet, joints that are bent in a fixed position (contractures), union or webbing of the skin between the fingers (syndactyly), and/or webbing of the neck, inside bend of the elbows, back of the knees and armpits. OMIM:178110 OMIM:253290 OMIM:265000 OMIM:312150 DOID:0080110 multiple pterygium syndrome DOID:0080132 OMIM:212350 mitochondrial DNA depletion syndrome 10 Sengers syndrome DOID:0090070 A hypogonadism characterized by a impaired signalling by gonadotrpin relasing hormone. ICD10CM:E23.0 OMIM:PS147950 ORDO:432 ORDO:478 congenital idiopathic hypogonadotropic hypogonadism isolated congenital gonadotropin deficiency doid DOID:0090070 hypogonadotropic hypogonadism DOID:0110734 A neurodegenerative disease characterized by progressive iron accumulation in the basal ganglia and other regions of the brain, resulting in extrapyramidal movements, such as parkinsonism and dystonia. ICD10CM:G23.0 MESH:C538421 OMIM:PS234200 ORDO:385 UMLS_CUI:C2931845 NBIA DOID:0110734 neurodegeneration with brain iron accumulation DOID:100 An intestinal disease that involves intestinal infection that has material basis in viruses, bacteria, fungi and parasites. DOID:10960 DOID:12509 DOID:5270 ICD10CM:A00-A09 ICD9CM:001-009.99 SNOMEDCT_US_2016_03_01:127322007 SNOMEDCT_US_2016_03_01:186086003 SNOMEDCT_US_2016_03_01:186171006 SNOMEDCT_US_2016_03_01:187266003 SNOMEDCT_US_2016_03_01:266071000 SNOMEDCT_US_2016_03_01:266172005 SNOMEDCT_US_2016_03_01:266180003 UMLS_CUI:C0178238 bacterial enteritis disease_ontology DOID:100 Updating outdated UMLS CUI. intestinal infectious disease DOID:10003 DOID:11053 DOID:12112 DOID:12114 ICD10CM:H90.5 ICD10CM:H91.9 ICD9CM:389.1 ICD9CM:389.10 ICD9CM:389.14 MESH:D006313 MESH:D006316 MESH:D006319 NCI:C26739 NCI:C34662 NCI:C34663 OMIM:304400 SNOMEDCT_US_2016_03_01:155256000 SNOMEDCT_US_2016_03_01:194421002 SNOMEDCT_US_2016_03_01:194427003 SNOMEDCT_US_2016_03_01:232326009 SNOMEDCT_US_2016_03_01:267770004 SNOMEDCT_US_2016_03_01:48758008 SNOMEDCT_US_2016_03_01:60700002 SNOMEDCT_US_2016_03_01:68467004 UMLS_CUI:C0018776 UMLS_CUI:C0018780 UMLS_CUI:C0018784 High Frequency Hearing Loss High frequency deafness Perceptive deafness Perceptive hearing loss Perceptive hearing loss or deafness Sensorineural Deafness Sensory hearing loss central hearing loss high-frequency hearing loss disease_ontology DOID:10003 OMIM mapping confirmed by DO. [LS]. sensorineural hearing loss DOID:10016 An autosomal dominant disease characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities. ICD10CM:E31.23 ICD9CM:258.03 MESH:D018814 NCI:C3227 OMIM:162300 ORDO:247709 SNOMEDCT_US_2016_03_01:61530001 UMLS_CUI:C0025269 MEN type IIB MEN2B Multiple endocrine neoplasia, type 3 Wagenmann-Froboese syndrome mucosal neuroma syndrome multiple endocrine neoplasia type 2b disease_ontology DOID:10016 OMIM mapping confirmed by DO. [SN]. multiple endocrine neoplasia type 2B DOID:10017 An autosomal dominant disease that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas. ICD10CM:E31.21 ICD9CM:258.01 MESH:D018761 NCI:C3225 OMIM:131100 ORDO:652 SNOMEDCT_US_2016_03_01:190566000 SNOMEDCT_US_2016_03_01:30664006 UMLS_CUI:C0025267 MEN type I Wermer syndrome Wermer's syndrome multiple endocrine neoplasia type 1 disease_ontology DOID:10017 OMIM mapping confirmed by DO. [SN]. multiple endocrine neoplasia type 1 DOID:10021 A small intestine cancer that is located_in the beginning section of the small intestine. DOID:6072 ICD10CM:C17.0 ICD9CM:152.0 MESH:D004379 NCI:C4803 NCI:C9328 SNOMEDCT_US_2016_03_01:154555009 SNOMEDCT_US_2016_03_01:254570009 SNOMEDCT_US_2016_03_01:269615000 SNOMEDCT_US_2016_03_01:363403002 UMLS_CUI:C0153426 UMLS_CUI:C0541912 Duodenal cancer cancer of duodenum duodenal neoplasm disease_ontology DOID:10021 duodenum cancer DOID:10024 A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon. DOID:10025 ICD10CM:G43.1 ICD10CM:G43.109 ICD9CM:346.0 MESH:D020325 NCI:C117005 OMIM:609179 OMIM:609670 SNOMEDCT_US_2016_03_01:155047002 SNOMEDCT_US_2016_03_01:4473006 UMLS_CUI:C0154723 classic migraine disease_ontology DOID:10024 Xref MGI. migraine with aura DOID:10027 A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction. ICD10CM:A52.11 ICD9CM:094.0 MESH:D013606 NCI:C35057 SNOMEDCT_US_2016_03_01:154384001 SNOMEDCT_US_2016_03_01:186885003 SNOMEDCT_US_2016_03_01:266134000 SNOMEDCT_US_2016_03_01:266210001 SNOMEDCT_US_2016_03_01:2844004 SNOMEDCT_US_2016_03_01:315826004 SNOMEDCT_US_2016_03_01:316841006 SNOMEDCT_US_2016_03_01:51928006 UMLS_CUI:C0039223 Posterior spinal sclerosis Tabes dorsalis - neurosyphilis disease_ontology DOID:10027 tabes dorsalis DOID:1003 ICD10CM:N70-N77 ICD10CM:N73.9 ICD9CM:614-616.99 ICD9CM:614.9 MESH:D000292 NCI:C3889 SNOMEDCT_US_2016_03_01:155967009 SNOMEDCT_US_2016_03_01:155968004 SNOMEDCT_US_2016_03_01:155974004 SNOMEDCT_US_2016_03_01:155986001 SNOMEDCT_US_2016_03_01:198130006 SNOMEDCT_US_2016_03_01:198131005 SNOMEDCT_US_2016_03_01:198178006 SNOMEDCT_US_2016_03_01:198244005 SNOMEDCT_US_2016_03_01:198570007 SNOMEDCT_US_2016_03_01:266584000 SNOMEDCT_US_2016_03_01:266648001 SNOMEDCT_US_2016_03_01:266651008 SNOMEDCT_US_2016_03_01:37518008 UMLS_CUI:C0242172 PID disease_ontology DOID:1003 pelvic inflammatory disease DOID:10033 ICD10CM:H52.52 ICD9CM:367.51 SNOMEDCT_US_2016_03_01:232141000 SNOMEDCT_US_2016_03_01:255335004 SNOMEDCT_US_2016_03_01:68158006 UMLS_CUI:C0235238 Ciliary muscle paresis Cycloplegic paralysis of accommodation Paresis of accommodation disease_ontology DOID:10033 cycloplegia DOID:10034 ICD10CM:H52.5 ICD9CM:367.5 SNOMEDCT_US_2016_03_01:155137002 SNOMEDCT_US_2016_03_01:193631008 SNOMEDCT_US_2016_03_01:54552008 UMLS_CUI:C0152198 disease_ontology DOID:10034 eye accommodation disease DOID:10080 A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected. ICD10CM:B70.1 ICD9CM:123.5 MESH:D013031 NCI:C35030 SNOMEDCT_US_2016_03_01:187152002 SNOMEDCT_US_2016_03_01:31659000 UMLS_CUI:C0037753 Infection by Sparganum Sparganosis [larval diphyllobothriasis] disease_ontology DOID:10080 sparganosis DOID:10095 A central nervous system disease that is located_in the skull and is characterized by a collection of pus (infected material) inside the skull. ICD9CM:324.0 NCI:C34734 SNOMEDCT_US_2016_03_01:192738001 SNOMEDCT_US_2016_03_01:192746000 SNOMEDCT_US_2016_03_01:27614006 UMLS_CUI:C0021874 disease_ontology DOID:10095 intracranial abscess DOID:10112 A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances. ICD10CM:B56 ICD10CM:B56.9 ICD9CM:086.5 KEGG:05143 MESH:D014353 NCI:C84541 SNOMEDCT_US_2016_03_01:186818008 SNOMEDCT_US_2016_03_01:187512007 SNOMEDCT_US_2016_03_01:27031003 SNOMEDCT_US_2016_03_01:78940002 UMLS_CUI:C0041228 African sleeping sickness African trypanosomiasis disease_ontology DOID:10112 sleeping sickness DOID:10113 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans. ICD10CM:B57.2 ICD9CM:086 ICD9CM:086.9 MESH:D014352 SNOMEDCT_US_2016_03_01:154375001 SNOMEDCT_US_2016_03_01:186819000 SNOMEDCT_US_2016_03_01:266205000 SNOMEDCT_US_2016_03_01:78940002 UMLS_CUI:C0041227 disease_ontology DOID:10113 trypanosomiasis DOID:10123 ICD9CM:709.09 UMLS_CUI:C0375489 disease_ontology DOID:10123 pigmentation disease DOID:10124 DOID:2284 ICD10CM:H18.9 ICD9CM:371.9 MESH:D003316 NCI:C26731 SNOMEDCT_US_2016_03_01:15250008 SNOMEDCT_US_2016_03_01:155160005 SNOMEDCT_US_2016_03_01:193794007 SNOMEDCT_US_2016_03_01:193856004 SNOMEDCT_US_2016_03_01:267733008 UMLS_CUI:C0010034 disease_ontology DOID:10124 corneal disease DOID:10126 A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape. ICD10CM:H18.6 ICD10CM:H18.60 ICD9CM:371.6 ICD9CM:371.60 MESH:D007640 NCI:C26806 OMIM:148300 OMIM:608586 OMIM:608932 OMIM:609271 OMIM:614622 OMIM:614623 OMIM:614628 OMIM:614629 ORDO:156071 SNOMEDCT_US_2016_03_01:155160005 SNOMEDCT_US_2016_03_01:193843006 SNOMEDCT_US_2016_03_01:193846003 SNOMEDCT_US_2016_03_01:267733008 SNOMEDCT_US_2016_03_01:65636009 UMLS_CUI:C0022578 conical cornea disease_ontology DOID:10126 Xref MGI. keratoconus DOID:10127 ICD9CM:434 ICD9CM:434.9 SNOMEDCT_US_2016_03_01:155400001 SNOMEDCT_US_2016_03_01:155403004 SNOMEDCT_US_2016_03_01:195188006 SNOMEDCT_US_2016_03_01:20059004 SNOMEDCT_US_2016_03_01:266255008 SNOMEDCT_US_2016_03_01:286956007 UMLS_CUI:C0028790 disease_ontology DOID:10127 cerebral artery occlusion DOID:10132 ICD9CM:302.79 UMLS_CUI:C0033951 disease_ontology DOID:10132 psychosexual disorder DOID:10140 ICD10CM:H04.12 MESH:D015352 NCI:C34553 SNOMEDCT_US_2016_03_01:155182003 SNOMEDCT_US_2016_03_01:193980001 SNOMEDCT_US_2016_03_01:46152009 UMLS_CUI:C0013238 Tear film insufficiency disease_ontology DOID:10140 dry eye syndrome DOID:10141 ICD10CM:H53.14 MESH:D001248 SNOMEDCT_US_2016_03_01:193645002 SNOMEDCT_US_2016_03_01:46640001 SNOMEDCT_US_2016_03_01:70323002 UMLS_CUI:C0004095 Accommodative strain disease_ontology DOID:10141 asthenopia DOID:10154 An intestinal cancer that is located_in the small intestine. ICD10CM:C17 ICD10CM:C17.9 ICD9CM:152.9 NCI:C7523 SNOMEDCT_US_2016_03_01:154555009 SNOMEDCT_US_2016_03_01:187755009 SNOMEDCT_US_2016_03_01:269615000 SNOMEDCT_US_2016_03_01:363509000 SNOMEDCT_US_2016_03_01:94048009 UMLS_CUI:C0153425 disease_ontology DOID:10154 small intestine cancer DOID:10155 A gastrointestinal system cancer that is located_in the intestine. ICD10CM:C26.0 ICD9CM:159.0 MESH:D007414 NCI:C4572 SNOMEDCT_US_2016_03_01:187819006 SNOMEDCT_US_2016_03_01:190089002 SNOMEDCT_US_2016_03_01:363508008 SNOMEDCT_US_2016_03_01:93838000 UMLS_CUI:C0346627 malignant intestinal tumors malignant neoplasm of intestine disease_ontology DOID:10155 intestinal cancer DOID:1019 A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow. DOID:1018 DOID:1020 DOID:10281 DOID:10282 DOID:10692 DOID:10860 DOID:1164 DOID:11788 DOID:11959 DOID:12011 DOID:13673 DOID:13674 DOID:13675 DOID:13678 DOID:13684 DOID:13737 DOID:14003 DOID:14100 DOID:14166 DOID:2249 DOID:2250 DOID:5858 DOID:9456 ICD9CM:730.01 ICD9CM:730.1 ICD9CM:730.10 ICD9CM:730.11 SNOMEDCT_US_2016_03_01:156791003 SNOMEDCT_US_2016_03_01:156800002 SNOMEDCT_US_2016_03_01:203181001 SNOMEDCT_US_2016_03_01:203183003 SNOMEDCT_US_2016_03_01:203205002 SNOMEDCT_US_2016_03_01:40970001 UMLS_CUI:C0008707 UMLS_CUI:C0158372 UMLS_CUI:C0158381 disease_ontology DOID:1019 osteomyelitis DOID:10211 EFO:0004799 ICD9CM:574.5 SNOMEDCT_US_2016_03_01:197397004 SNOMEDCT_US_2016_03_01:266475002 UMLS_CUI:C0006739 disease_ontology DOID:10211 cholelithiasis DOID:1024 A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage. EFO:0001054 ICD10CM:A30 ICD10CM:A30.9 ICD9CM:030 ICD9CM:030.9 MESH:D007918 NCI:C84824 OMIM:246300 OMIM:607572 OMIM:609888 OMIM:610988 OMIM:613223 OMIM:613407 ORDO:548 SNOMEDCT_US_2016_03_01:154298007 SNOMEDCT_US_2016_03_01:186339006 SNOMEDCT_US_2016_03_01:187316006 SNOMEDCT_US_2016_03_01:266184007 SNOMEDCT_US_2016_03_01:81004002 UMLS_CUI:C0023343 disease_ontology DOID:1024 Xref MGI. leprosy DOID:10241 DOID:12242 DOID:12243 ICD10CM:D56 ICD10CM:D56.9 ICD9CM:282.4 ICD9CM:282.40 MESH:D013789 NCI:C35069 OMIM:604131 SNOMEDCT_US_2016_03_01:154796005 SNOMEDCT_US_2016_03_01:191182000 SNOMEDCT_US_2016_03_01:191192008 SNOMEDCT_US_2016_03_01:191193003 SNOMEDCT_US_2016_03_01:267521001 SNOMEDCT_US_2016_03_01:267557006 SNOMEDCT_US_2016_03_01:40108008 SNOMEDCT_US_2016_03_01:84188003 UMLS_CUI:C0039730 Sickle-cell thalassemia with crisis Sickle-cell thalassemia without crisis thalassemia Hb-S disease with crisis thalassemia Hb-S disease without crisis disease_ontology DOID:10241 OMIM mapping confirmed by DO. [LS]. thalassemia DOID:10242 A primary bacterial infectious disease that results_in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash. DOID:0050023 ICD10CM:A77.4 ICD10CM:A77.40 ICD9CM:082.4 ICD9CM:082.40 MESH:D016873 SNOMEDCT_US_2016_03_01:77361002 UMLS_CUI:C0085399 human ehrlichiosis disease_ontology DOID:10242 ehrlichiosis DOID:10264 A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face. ICD10CM:B26 ICD10CM:B26.9 ICD9CM:072 MESH:D009107 NCI:C29888 SNOMEDCT_US_2016_03_01:154352008 SNOMEDCT_US_2016_03_01:186651001 SNOMEDCT_US_2016_03_01:186652008 SNOMEDCT_US_2016_03_01:240526004 SNOMEDCT_US_2016_03_01:36989005 UMLS_CUI:C0026780 disease_ontology DOID:10264 mumps DOID:10273 A cardiovascular system disease that involves the heart's electrical conduction system. ICD9CM:426.6 SNOMEDCT_US_2016_03_01:195053008 SNOMEDCT_US_2016_03_01:195056000 UMLS_CUI:C0029630 heart rhythm disease disease_ontology DOID:10273 heart conduction disease DOID:10283 A male reproductive organ cancer that is located_in the prostate. DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 SNOMEDCT_US_2016_03_01:126906006 SNOMEDCT_US_2016_03_01:363448003 SNOMEDCT_US_2016_03_01:399068003 SNOMEDCT_US_2016_03_01:93974005 UMLS_CUI:C0033578 UMLS_CUI:C0376358 NGP - new growth of prostate hereditary prostate cancer malignant tumor of the prostate prostate cancer, familial prostate neoplasm prostatic cancer prostatic neoplasm tumor of the prostate disease_ontology DOID:10283 Xref MGI. OMIM mapping confirmed by DO. [SN]. prostate cancer DOID:10286 A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. EFO:0001663 KEGG:05215 NCI:C4863 SNOMEDCT_US_2016_03_01:154531004 SNOMEDCT_US_2016_03_01:254900004 SNOMEDCT_US_2016_03_01:363448003 UMLS_CUI:C0600139 cancer of prostate carcinoma OF PROSTATE carcinoma of prostate carcinoma of prostate (disorder) disease_ontology DOID:10286 prostate carcinoma DOID:1029 ICD10CM:G72.3 MESH:D010245 NCI:C84709 SNOMEDCT_US_2016_03_01:155099000 SNOMEDCT_US_2016_03_01:193241004 SNOMEDCT_US_2016_03_01:267607008 SNOMEDCT_US_2016_03_01:267714003 SNOMEDCT_US_2016_03_01:54696002 UMLS_CUI:C0030443 disease_ontology DOID:1029 familial periodic paralysis DOID:10300 ICD10CM:I73.0 MESH:D011928 OMIM:179600 SNOMEDCT_US_2016_03_01:123266007 SNOMEDCT_US_2016_03_01:195295006 SNOMEDCT_US_2016_03_01:22954002 UMLS_CUI:C0034734 Raynaud's disease Raynaud's disease (disorder) Raynaud's syndrome Raynaud's syndrome (disorder) Raynaud's syndrome (disorder) [Ambiguous] Raynaud's syndrome NOS (disorder) disease_ontology DOID:10300 OMIM mapping confirmed by DO. [SN]. Raynaud disease DOID:10314 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves. DOID:14058 ICD10CM:I33.9 ICD9CM:421.9 MESH:D004696 NCI:C34582 NCI:C35432 SNOMEDCT_US_2016_03_01:194935007 SNOMEDCT_US_2016_03_01:56819008 SNOMEDCT_US_2016_03_01:91357005 UMLS_CUI:C0014118 UMLS_CUI:C0375268 disease_ontology DOID:10314 endocarditis DOID:10316 An interstitial lung disease that is caused by the inhalation of dust. ICD10CM:J64 ICD9CM:505 MESH:D011009 NCI:C26861 SNOMEDCT_US_2016_03_01:155587002 SNOMEDCT_US_2016_03_01:155591007 SNOMEDCT_US_2016_03_01:196004000 SNOMEDCT_US_2016_03_01:196016006 SNOMEDCT_US_2016_03_01:266401007 SNOMEDCT_US_2016_03_01:40122008 UMLS_CUI:C0032273 disease_ontology DOID:10316 pneumoconiosis DOID:10323 ICD10CM:J66.0 MESH:D002095 NCI:C84605 SNOMEDCT_US_2016_03_01:155589004 SNOMEDCT_US_2016_03_01:233689004 SNOMEDCT_US_2016_03_01:266400008 SNOMEDCT_US_2016_03_01:85761009 UMLS_CUI:C0006542 Flax-dressers' disease Stripper's asthma cotton mill fever disease_ontology DOID:10323 byssinosis DOID:10348 ICD10CM:H02.52 ICD9CM:374.46 MESH:D016569 UMLS_CUI:C0005744 disease_ontology DOID:10348 blepharophimosis DOID:10350 ICD10CM:N60.0 MESH:D047688 NCI:C5315 SNOMEDCT_US_2016_03_01:270538000 SNOMEDCT_US_2016_03_01:399294002 SNOMEDCT_US_2016_03_01:56726003 UMLS_CUI:C0006144 Cyst of the breast disease_ontology DOID:10350 breast cyst DOID:1037 A leukemia that has_material_basis_in lymphoblasts (immature white blood cells). ICD10CM:C91 ICD10CM:C91.9 ICD10CM:C91.90 ICD9CM:204 ICD9CM:204.9 MESH:D007945 NCI:C7539 SNOMEDCT_US_2016_03_01:154587007 SNOMEDCT_US_2016_03_01:188725004 SNOMEDCT_US_2016_03_01:188731001 SNOMEDCT_US_2016_03_01:190033006 SNOMEDCT_US_2016_03_01:269631008 SNOMEDCT_US_2016_03_01:32280000 SNOMEDCT_US_2016_03_01:93170002 UMLS_CUI:C0023448 disease_ontology DOID:1037 lymphoblastic leukemia DOID:10375 ICD10CM:H53.03 ICD9CM:368.01 MESH:D000550 SNOMEDCT_US_2016_03_01:35600002 UMLS_CUI:C0750903 Strabismic amblyopia disease_ontology DOID:10375 suppression amblyopia DOID:10376 CSP:1114-9655 ICD10CM:H53.00 ICD9CM:368.00 MESH:D000550 NCI:C118764 SNOMEDCT_US_2016_03_01:111517004 SNOMEDCT_US_2016_03_01:155145007 SNOMEDCT_US_2016_03_01:193637007 SNOMEDCT_US_2016_03_01:267627009 SNOMEDCT_US_2016_03_01:267726008 SNOMEDCT_US_2016_03_01:387742006 UMLS_CUI:C0002418 disease_ontology DOID:10376 amblyopia DOID:10378 ICD10CM:H53.01 ICD9CM:368.02 SNOMEDCT_US_2016_03_01:193638002 SNOMEDCT_US_2016_03_01:21457000 UMLS_CUI:C0152189 Deprivation amblyopia disease_ontology DOID:10378 disuse amblyopia DOID:104 A disease by infectious agent that results_in infection, has_material_basis_in Bacteria. ICD10CM:A49 ICD10CM:A49.9 MESH:D001424 MESH:D016905 MESH:D016908 NCI:C2890 SNOMEDCT_US_2016_03_01:154318005 SNOMEDCT_US_2016_03_01:186470002 SNOMEDCT_US_2016_03_01:187347000 SNOMEDCT_US_2016_03_01:266182006 SNOMEDCT_US_2016_03_01:266187000 SNOMEDCT_US_2016_03_01:301811001 SNOMEDCT_US_2016_03_01:87628006 UMLS_CUI:C0004623 disease_ontology DOID:104 bacterial infectious disease DOID:1040 A lymphoblastic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. EFO:0000095 ICD10CM:C91.1 ICD10CM:C91.10 ICD9CM:204.1 MESH:D015451 NCI:C3163 OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559 ORDO:67038 SNOMEDCT_US_2016_03_01:154589005 SNOMEDCT_US_2016_03_01:277473004 SNOMEDCT_US_2016_03_01:51092000 SNOMEDCT_US_2016_03_01:92814006 UMLS_CUI:C0023434 B-cell chronic lymphocytic leukemia CLL chronic lymphatic leukemia lymphoplasmacytic leukemia disease_ontology B-cell chronic lymphoid leukemia DOID:1040 Xref MGI. chronic lymphocytic leukemia DOID:10426 A physical disorder that has_material_basis_in abnormal segmentation of the vertebra during fetal development which results_in fusion located_in cervical vertebra. DOID:14747 ICD10CM:Q76.1 ICD9CM:756.16 MESH:D007714 NCI:C98967 OMIM:118100 OMIM:214300 OMIM:613702 ORDO:2345 SNOMEDCT_US_2016_03_01:129581007 SNOMEDCT_US_2016_03_01:157003009 SNOMEDCT_US_2016_03_01:205441002 SNOMEDCT_US_2016_03_01:268349005 SNOMEDCT_US_2016_03_01:388981000 SNOMEDCT_US_2016_03_01:5601008 UMLS_CUI:C0022738 Klippel-Feil and Turner syndrome Klippel-Feil deformity, deafness and facial asymmetry autosomal dominant Klippel-Feil syndrome congenital dystrophia brevicollis congenital synostosis of cervical vertebrae disease_ontology DOID:10426 Xref MGI. OMIM mapping confirmed by DO. [SN]. Klippel-Feil syndrome DOID:10456 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur. DOID:10454 DOID:13751 ICD10CM:J35.01 ICD9CM:474.00 MESH:D014069 NCI:C116006 SNOMEDCT_US_2016_03_01:155530006 SNOMEDCT_US_2016_03_01:195665006 SNOMEDCT_US_2016_03_01:195794009 SNOMEDCT_US_2016_03_01:90176007 SNOMEDCT_US_2016_03_01:90979004 UMLS_CUI:C0040425 UMLS_CUI:C0149517 Throat infection - tonsillitis chronic tonsillitis disease_ontology DOID:10456 tonsillitis DOID:10457 A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough. ICD10CM:A48.1 ICD9CM:482.84 MESH:D007877 SNOMEDCT_US_2016_03_01:154315008 SNOMEDCT_US_2016_03_01:195889001 SNOMEDCT_US_2016_03_01:266186009 SNOMEDCT_US_2016_03_01:269574000 SNOMEDCT_US_2016_03_01:312403005 SNOMEDCT_US_2016_03_01:74881002 UMLS_CUI:C0023241 (Legionella) or (Legionnaire's disease) Infection by Legionella pneumophilia (disorder) Legionella pneumonia (disorder) disease_ontology DOID:10457 Legionnaires' disease DOID:10458 A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea. MESH:D007876 SNOMEDCT_US_2016_03_01:26726000 UMLS_CUI:C0023240 Legionella infection (disorder) disease_ontology DOID:10458 legionellosis DOID:10459 An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus. ICD10CM:J00 ICD9CM:460 MESH:D003139 NCI:C34500 NCI:C78599 SNOMEDCT_US_2016_03_01:155497009 SNOMEDCT_US_2016_03_01:195648002 SNOMEDCT_US_2016_03_01:232341009 SNOMEDCT_US_2016_03_01:232342002 SNOMEDCT_US_2016_03_01:266377009 SNOMEDCT_US_2016_03_01:54150009 SNOMEDCT_US_2016_03_01:82272006 UMLS_CUI:C0009443 Acute viral rhinopharyngitis Nasopharyngitis - acute Nasopharyngitis, acute acute Nasopharyngitis acute coryza acute nasopharyngitis [common cold] acute rhinitis rhino-sinusitis disease_ontology DOID:10459 common cold DOID:10471 ICD10CM:M76.5 ICD10CM:M76.50 ICD9CM:726.64 SNOMEDCT_US_2016_03_01:156662006 SNOMEDCT_US_2016_03_01:268089006 SNOMEDCT_US_2016_03_01:37785001 UMLS_CUI:C0158317 Patellar tendonitis (disorder) disease_ontology DOID:10471 patellar tendinitis DOID:10480 ICD10CM:Q79.1 MESH:D003965 NCI:C98912 SNOMEDCT_US_2016_03_01:157006001 SNOMEDCT_US_2016_03_01:268351009 SNOMEDCT_US_2016_03_01:34168003 UMLS_CUI:C0011981 disease_ontology DOID:10480 diaphragmatic eventration DOID:10481 A muscular disease that is located_in the diaphragm. ICD10CM:J98.6 ICD9CM:519.4 SNOMEDCT_US_2016_03_01:196182001 SNOMEDCT_US_2016_03_01:48475001 UMLS_CUI:C0152097 disease_ontology DOID:10481 diaphragm disease DOID:10487 A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel. ICD10CM:Q43.1 MESH:D006627 NCI:C34700 OMIM:142623 OMIM:600155 OMIM:600156 OMIM:606874 OMIM:606875 OMIM:608462 OMIM:611644 OMIM:613711 OMIM:613712 ORDO:388 SNOMEDCT_US_2016_03_01:156957008 SNOMEDCT_US_2016_03_01:204738000 SNOMEDCT_US_2016_03_01:204739008 SNOMEDCT_US_2016_03_01:204742002 SNOMEDCT_US_2016_03_01:204744001 SNOMEDCT_US_2016_03_01:360436002 SNOMEDCT_US_2016_03_01:367495003 SNOMEDCT_US_2016_03_01:6687001 UMLS_CUI:C0019569 Hirschsprung disease aganglionic megacolon congenital megacolon macrocolon pelvirectal achalasia total intestinal aganglionosis disease_ontology DOID:10487 Xref MGI. OMIM mapping confirmed by DO. [SN]. Hirschsprung's disease DOID:10488 ICD10CM:Q42.3 MESH:D001006 NCI:C84784 OMIM:207500 OMIM:301800 SNOMEDCT_US_2016_03_01:14118000 SNOMEDCT_US_2016_03_01:156956004 SNOMEDCT_US_2016_03_01:204712000 SNOMEDCT_US_2016_03_01:204731006 SNOMEDCT_US_2016_03_01:204733009 UMLS_CUI:C0003466 Congenital atresia of anus Congenital or infantile occlusion of anus Imperforate anus anal atresia disease_ontology DOID:10488 OMIM mapping confirmed by DO. [SN]. imperforate anus DOID:10493 ICD9CM:255.4 NCI:C26691 SNOMEDCT_US_2016_03_01:154707007 SNOMEDCT_US_2016_03_01:190527008 SNOMEDCT_US_2016_03_01:267398003 SNOMEDCT_US_2016_03_01:267483004 SNOMEDCT_US_2016_03_01:386584007 SNOMEDCT_US_2016_03_01:68588005 UMLS_CUI:C0405580 Adrenal Cortical Insufficiency Corticoadrenal insufficiency disease_ontology DOID:10493 adrenal cortical hypofunction DOID:10507 A pericarditis characterized by inflammation, occurring after injury, located_in pericardium. ICD10CM:I24.1 ICD9CM:411.0 SNOMEDCT_US_2016_03_01:66189004 UMLS_CUI:C0152107 Dressler syndrome Postmyocardial infarction syndrome Postmyocardial infarction syndrome (disorder) disease_ontology DOID:10507 Dressler's syndrome DOID:10534 A gastrointestinal system cancer that is located_in the stomach. DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD10CM:C16.9 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:137215 OMIM:613659 SNOMEDCT_US_2016_03_01:126824007 SNOMEDCT_US_2016_03_01:154450001 SNOMEDCT_US_2016_03_01:154451002 SNOMEDCT_US_2016_03_01:154452009 SNOMEDCT_US_2016_03_01:154453004 SNOMEDCT_US_2016_03_01:187731004 SNOMEDCT_US_2016_03_01:187742008 SNOMEDCT_US_2016_03_01:187743003 SNOMEDCT_US_2016_03_01:187744009 SNOMEDCT_US_2016_03_01:187750004 SNOMEDCT_US_2016_03_01:255080008 SNOMEDCT_US_2016_03_01:269458007 SNOMEDCT_US_2016_03_01:269459004 SNOMEDCT_US_2016_03_01:269460009 SNOMEDCT_US_2016_03_01:269529007 SNOMEDCT_US_2016_03_01:269530002 SNOMEDCT_US_2016_03_01:269531003 SNOMEDCT_US_2016_03_01:269532005 SNOMEDCT_US_2016_03_01:363349007 SNOMEDCT_US_2016_03_01:93717002 SNOMEDCT_US_2016_03_01:93818001 SNOMEDCT_US_2016_03_01:93867004 SNOMEDCT_US_2016_03_01:94074003 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423 Ca body - stomach Ca lesser curvature - stomach (disorder) ca greater curvature of stomach gastric neoplasm malignant neoplasm of body of stomach malignant neoplasm of lesser curve of stomach unspecified (disorder) malignant tumor of body of stomach (disorder) malignant tumor of greater curve of stomach (disorder) malignant tumor of lesser curve of stomach (disorder) disease_ontology DOID:10534 OMIM mapping confirmed by DO. [SN]. stomach cancer DOID:10540 MESH:C535648 NCI:C4636 SNOMEDCT_US_2016_03_01:276811008 UMLS_CUI:C0349532 Lymphoma of the stomach disease_ontology DOID:10540 gastric lymphoma DOID:10548 ICD10CM:C16.0 ICD9CM:151.0 SNOMEDCT_US_2016_03_01:154447004 SNOMEDCT_US_2016_03_01:187732006 SNOMEDCT_US_2016_03_01:187735008 SNOMEDCT_US_2016_03_01:269526000 SNOMEDCT_US_2016_03_01:93738008 UMLS_CUI:C0153417 Ca cardia - stomach malignant neoplasm of cardia of stomach disease_ontology DOID:10548 cardia cancer DOID:1056 ICD10CM:E72.03 MESH:D009800 NCI:C84940 OMIM:309000 SNOMEDCT_US_2016_03_01:79385002 UMLS_CUI:C0028860 Lowe syndrome lowe oculocerebrorenal syndrome oculocerebrorenal syndrome of Lowe disease_ontology DOID:1056 OMIM mapping confirmed by DO. [SN]. oculocerebrorenal syndrome DOID:10573 A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone. ICD9CM:268.2 NCI:C26838 SNOMEDCT_US_2016_03_01:154728003 SNOMEDCT_US_2016_03_01:190639009 SNOMEDCT_US_2016_03_01:190642003 SNOMEDCT_US_2016_03_01:4598005 UMLS_CUI:C0029442 disease_ontology DOID:10573 osteomalacia DOID:10575 ICD10CM:E83.5 ICD10CM:E83.50 ICD9CM:275.4 ICD9CM:275.40 MESH:D002128 SNOMEDCT_US_2016_03_01:190863003 SNOMEDCT_US_2016_03_01:190874007 SNOMEDCT_US_2016_03_01:267442002 SNOMEDCT_US_2016_03_01:71638002 UMLS_CUI:C0006705 disease_ontology DOID:10575 calcium metabolism disease DOID:10579 A cerebral degeneration characterized by dysfunction of the white matter of the brain. ICD9CM:330.0 NCI:C61253 SNOMEDCT_US_2016_03_01:192781003 SNOMEDCT_US_2016_03_01:192785007 SNOMEDCT_US_2016_03_01:5101009 UMLS_CUI:C0023520 disease_ontology DOID:10579 leukodystrophy DOID:10581 A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system. ICD10CM:E75.25 ICD10CM:E75.29 MESH:D007966 NCI:C61251 OMIM:249900 OMIM:250100 ORDO:512 SNOMEDCT_US_2016_03_01:192784006 SNOMEDCT_US_2016_03_01:3621006 SNOMEDCT_US_2016_03_01:396338004 SNOMEDCT_US_2016_03_01:44359008 UMLS_CUI:C0023522 MLD Scholz cerebral sclerosis arylsulfatase A deficiency deficiency of cerebroside-sulfatase sulfatide lipoidosis disease_ontology DOID:10581 Xref MGI. OMIM mapping confirmed by DO. [SN]. metachromatic leukodystrophy DOID:10584 A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss. DOID:14742 ICD10CM:H35.52 MESH:C538365 MESH:D012174 NCI:C85045 OMIM:268000 ORDO:791 SNOMEDCT_US_2016_03_01:155113002 SNOMEDCT_US_2016_03_01:28835009 UMLS_CUI:C0035334 UMLS_CUI:C0220701 pericentral pigmentary retinopathy retinitis pigmentosa type 53 retinitis pigmentosa type 59 retinitis pigmentosa-1 disease_ontology DOID:10584 Xref MGI. OMIM mapping confirmed by DO. [LS]. retinitis pigmentosa DOID:10587 ICD10CM:E75.23 MESH:D007965 NCI:C61254 OMIM:245200 SNOMEDCT_US_2016_03_01:189979005 SNOMEDCT_US_2016_03_01:192782005 SNOMEDCT_US_2016_03_01:5710006 UMLS_CUI:C0023521 Diffuse globoid body sclerosis GLOBOID CELL LEUKOENCEPHALOPATHY Galactosylceramide beta-galactosidase deficiency (disorder) Krabbe's disease Krabbe's leukodystrophy beta galactocerebrosidase deficiency globoid cell leukodystrophy disease_ontology DOID:10587 OMIM mapping confirmed by DO. [SN]. Krabbe disease DOID:10588 A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death. DOID:13451 ICD10CM:E71.52 ICD10CM:E71.529 ICD10CM:G37.0 ICD9CM:341.1 MESH:D000326 MESH:D002549 NCI:C61252 NCI:C84670 OMIM:202370 OMIM:300100 SNOMEDCT_US_2016_03_01:155059003 SNOMEDCT_US_2016_03_01:192932009 SNOMEDCT_US_2016_03_01:267702006 SNOMEDCT_US_2016_03_01:44875002 SNOMEDCT_US_2016_03_01:49692006 SNOMEDCT_US_2016_03_01:65389002 UMLS_CUI:C0007795 UMLS_CUI:C0162309 ALD Bronze Schilder disease Encephalitis periaxialis concentrica Encephalitis periaxialis, Schilder's SUDANOPHILIC CEREBRAL SCLEROSIS Schilder disease Siemerling-Creutzfeldt Disease X-linked adrenoleukodystrophy diffuse sclerosis disease_ontology Schilder's disease diffuse cerebral sclerosis of Schilder DOID:10588 MESH:D000326w added from NeuroDevNet [WAK]. adrenoleukodystrophy DOID:1059 A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills. NCI:C84392 SNOMEDCT_US_2016_03_01:154978008 SNOMEDCT_US_2016_03_01:154979000 SNOMEDCT_US_2016_03_01:1855002 SNOMEDCT_US_2016_03_01:192157003 SNOMEDCT_US_2016_03_01:192557008 SNOMEDCT_US_2016_03_01:268732001 SNOMEDCT_US_2016_03_01:91138005 UMLS_CUI:C0025362 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 15 disease_ontology mental retardation DOID:1059 OMIM mapping submitted by NeuroDevNet. [LS]. intellectual disability DOID:10591 A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy. DOID:12684 ICD10CM:O14 ICD10CM:O14.9 ICD10CM:O14.90 MESH:D011225 NCI:C34943 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 SNOMEDCT_US_2016_03_01:15394000 SNOMEDCT_US_2016_03_01:156106005 SNOMEDCT_US_2016_03_01:156109003 SNOMEDCT_US_2016_03_01:198972006 SNOMEDCT_US_2016_03_01:198979002 SNOMEDCT_US_2016_03_01:199011002 SNOMEDCT_US_2016_03_01:237280005 SNOMEDCT_US_2016_03_01:267306006 SNOMEDCT_US_2016_03_01:288201007 SNOMEDCT_US_2016_03_01:398254007 SNOMEDCT_US_2016_03_01:46764007 SNOMEDCT_US_2016_03_01:6758009 UMLS_CUI:C0032914 gestational hypertension hypertension induced by pregnancy pre-eclamptic toxaemia preeclampsia preeclampsia/eclampsia pregnancy associated hypertension pregnancy toxemia proteinuric hypertension of pregnancy toxaemia of pregnancy disease_ontology DOID:10591 Xref MGI. OMIM mapping confirmed by DO. [SN]. pre-eclampsia DOID:10595 A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm. ICD10CM:G60.0 ICD9CM:356.1 MESH:D002607 NCI:C75467 OMIM:PS118220 SNOMEDCT_US_2016_03_01:128202008 SNOMEDCT_US_2016_03_01:193158000 SNOMEDCT_US_2016_03_01:193162006 SNOMEDCT_US_2016_03_01:50548001 UMLS_CUI:C0007959 CMT - Charcot-Marie-Tooth disease Charcot Marie Tooth muscular atrophy Peroneal muscular atrophy disease_ontology DOID:10595 Charcot-Marie-Tooth disease DOID:10600 A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year. ICD10CM:F95.1 ICD9CM:307.22 MESH:D013981 NCI:C116768 SNOMEDCT_US_2016_03_01:192623005 UMLS_CUI:C0008701 chronic motor or vocal tic disorder disease_ontology DOID:10600 chronic tic disorder DOID:10602 MESH:D045602 NCI:C86917 SNOMEDCT_US_2016_03_01:197489007 SNOMEDCT_US_2016_03_01:266481005 SNOMEDCT_US_2016_03_01:27868004 SNOMEDCT_US_2016_03_01:66187002 UMLS_CUI:C0038238 Fatty stool (finding) disease_ontology DOID:10602 steatorrhea DOID:10603 ICD10CM:R73.09 MESH:D018149 NCI:C34646 SNOMEDCT_US_2016_03_01:154720005 SNOMEDCT_US_2016_03_01:190752008 SNOMEDCT_US_2016_03_01:267426009 SNOMEDCT_US_2016_03_01:9414007 UMLS_CUI:C0271650 Glucose: [intolerance] or [malabsorption] Malabsorption of glucose (disorder) disease_ontology DOID:10603 glucose intolerance DOID:10605 MESH:D012778 NCI:C99059 SNOMEDCT_US_2016_03_01:204768009 SNOMEDCT_US_2016_03_01:235724004 SNOMEDCT_US_2016_03_01:26629001 UMLS_CUI:C0036992 acquired short bowel syndrome short gut syndrome disease_ontology DOID:10605 short bowel syndrome DOID:10608 An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite. EFO:0001060 ICD10CM:K90.0 ICD9CM:579.0 MESH:D002446 NCI:C26714 OMIM:212750 OMIM:607202 OMIM:609753 OMIM:609754 OMIM:609755 OMIM:611598 OMIM:612005 OMIM:612006 OMIM:612007 OMIM:612008 OMIM:612009 OMIM:612011 ORDO:555 SNOMEDCT_US_2016_03_01:155842007 SNOMEDCT_US_2016_03_01:197477005 SNOMEDCT_US_2016_03_01:197481005 SNOMEDCT_US_2016_03_01:23829007 SNOMEDCT_US_2016_03_01:266478000 SNOMEDCT_US_2016_03_01:396331005 UMLS_CUI:C0007570 celiac sprue coeliac disease idiopathic steatorrhea disease_ontology DOID:10608 Xref MGI. OMIM mapping confirmed by DO. [SN]. celiac disease DOID:10609 A bone remodeling disease that has_material_basis_in impaired mineralization or calcification of bones before epiphyseal closure due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium which results_in softening and deformity located_in bone. DOID:11672 ICD10CM:E55.0 ICD9CM:268.0 MESH:D012279 NCI:C26878 OMIM:264700 OMIM:277440 OMIM:600081 OMIM:600785 ORDO:289157 SNOMEDCT_US_2016_03_01:154728003 SNOMEDCT_US_2016_03_01:190639009 SNOMEDCT_US_2016_03_01:190640006 SNOMEDCT_US_2016_03_01:41345002 SNOMEDCT_US_2016_03_01:68295002 UMLS_CUI:C0035579 UMLS_CUI:C0221468 active rickets vitamin D hydroxylation-deficient rickets vitamin D-dependent rickets disease_ontology DOID:10609 Xref MGI. rickets DOID:10611 MESH:D011504 OMIM:226300 SNOMEDCT_US_2016_03_01:22542007 SNOMEDCT_US_2016_03_01:66972006 UMLS_CUI:C0033680 Enteropathy, exudative Exudative enteropathy (disorder) Protein-losing enteropathy (disorder) disease_ontology DOID:10611 OMIM mapping confirmed by DO. [SN]. protein-losing enteropathy DOID:10629 An eye disease where one or both eyeballs are abnormally small. DOID:10650 ICD10CM:Q11.2 ICD9CM:743.1 ICD9CM:743.10 ICD9CM:743.11 MESH:D008850 NCI:C98989 OMIM:206900 OMIM:300166 OMIM:309801 OMIM:600165 OMIM:601186 OMIM:607932 OMIM:609549 OMIM:610093 OMIM:610125 OMIM:611038 OMIM:611040 OMIM:611897 OMIM:613094 OMIM:613704 OMIM:615972 ORDO:35612 SNOMEDCT_US_2016_03_01:156902006 SNOMEDCT_US_2016_03_01:204104003 SNOMEDCT_US_2016_03_01:204107005 SNOMEDCT_US_2016_03_01:204108000 SNOMEDCT_US_2016_03_01:204110003 SNOMEDCT_US_2016_03_01:268310007 SNOMEDCT_US_2016_03_01:61142002 UMLS_CUI:C0026010 microphthalmos nanophthalmia nanophthalmos simple microphthalmos disease_ontology DOID:10629 Xref MGI. OMIM mapping confirmed by DO. [SN]. microphthalmia DOID:1063 ICD10CM:N12 MESH:D009395 NCI:C26834 SNOMEDCT_US_2016_03_01:264536006 SNOMEDCT_US_2016_03_01:28689008 UMLS_CUI:C0027707 renal tubulo-interstitial disease disease_ontology DOID:1063 interstitial nephritis DOID:10632 An autosomal recessive disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1). MESH:D014929 NCI:C35133 SNOMEDCT_US_2016_03_01:70694009 UMLS_CUI:C0043207 DIDMOAD Diabetes mellitus AND insipidus with optic atrophy AND deafness (disorder) WFS disease_ontology DOID:10632 OMIM mapping confirmed by DO. [LS]. Wolfram syndrome DOID:1064 A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and has material basis in mutations in the CTNS gene, located on chromosome 17. ICD10CM:E72.04 MESH:D003554 NCI:C2976 OMIM:219750 OMIM:219800 OMIM:219900 ORDO:213 SNOMEDCT_US_2016_03_01:111398009 SNOMEDCT_US_2016_03_01:190681003 SNOMEDCT_US_2016_03_01:190683000 SNOMEDCT_US_2016_03_01:367374009 SNOMEDCT_US_2016_03_01:62332007 UMLS_CUI:C2931187 cystine storage disease disease_ontology DOID:1064 cystinosis DOID:10652 A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. EFO:0000249 ICD10CM:G30 ICD10CM:G30.9 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 OMIM:104300 OMIM:502500 OMIM:604154 SNOMEDCT_US_2016_03_01:154998003 SNOMEDCT_US_2016_03_01:267688001 SNOMEDCT_US_2016_03_01:26929004 SNOMEDCT_US_2016_03_01:73768007 UMLS_CUI:C0002395 AD Alzheimer disease Alzheimers dementia disease_ontology Alzheimer disease, familial DOID:10652 Xref MGI. OMIM mapping confirmed by DO. [SN]. Alzheimer's disease DOID:1067 A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage. EFO:0004190 ICD10CM:H40.1 ICD10CM:H40.10 ICD10CM:H40.13 ICD9CM:365.1 ICD9CM:365.10 ICD9CM:365.13 MESH:D005902 NCI:C34641 OMIM:137750 OMIM:177700 OMIM:601682 OMIM:602429 OMIM:603383 OMIM:606689 OMIM:608695 OMIM:608696 OMIM:609745 OMIM:609887 OMIM:610535 OMIM:611274 OMIM:611276 OMIM:613100 SNOMEDCT_US_2016_03_01:111513000 SNOMEDCT_US_2016_03_01:193538009 SNOMEDCT_US_2016_03_01:193539001 SNOMEDCT_US_2016_03_01:193543002 SNOMEDCT_US_2016_03_01:46168003 SNOMEDCT_US_2016_03_01:84494001 UMLS_CUI:C0017612 Wide-angle glaucoma glaucoma simplex open angle glaucoma pigmentary glaucoma disease_ontology DOID:1067 Xref MGI. open-angle glaucoma DOID:10686 ICD10CM:N64.89 ICD9CM:611.5 MESH:C535998 NCI:C3515 SNOMEDCT_US_2016_03_01:155966000 SNOMEDCT_US_2016_03_01:266647006 SNOMEDCT_US_2016_03_01:42385006 UMLS_CUI:C0152243 Galactocele disease_ontology DOID:10686 lactocele DOID:10690 MESH:D008413 NCI:C53662 SNOMEDCT_US_2016_03_01:155952005 SNOMEDCT_US_2016_03_01:155955007 SNOMEDCT_US_2016_03_01:198099006 SNOMEDCT_US_2016_03_01:266641007 SNOMEDCT_US_2016_03_01:266644004 SNOMEDCT_US_2016_03_01:45198002 UMLS_CUI:C0024894 Inflammatory breast disease Inflammatory disease of breast breast inflammation disease_ontology DOID:10690 mastitis DOID:1070 ICD10CM:H40.11 ICD9CM:365.11 MESH:C562750 NCI:C35394 OMIM:137760 SNOMEDCT_US_2016_03_01:155122001 SNOMEDCT_US_2016_03_01:77075001 UMLS_CUI:C0339573 chronic simple glaucoma disease_ontology DOID:1070 OMIM mapping confirmed by DO. [SN]. primary open angle glaucoma DOID:10718 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting. ICD10CM:A07.1 ICD9CM:007.1 MESH:D005873 SNOMEDCT_US_2016_03_01:10679007 SNOMEDCT_US_2016_03_01:154275004 SNOMEDCT_US_2016_03_01:186124000 SNOMEDCT_US_2016_03_01:266075009 SNOMEDCT_US_2016_03_01:266176008 SNOMEDCT_US_2016_03_01:58265007 UMLS_CUI:C0017536 Infection by Giardia lamblia beaver feaver disease_ontology DOID:10718 giardiasis DOID:1073 MESH:D006977 NCI:C3121 SNOMEDCT_US_2016_03_01:194775007 SNOMEDCT_US_2016_03_01:28119000 UMLS_CUI:C0020544 disease_ontology DOID:1073 renal hypertension DOID:1074 A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. ICD10CM:N19 ICD9CM:586 MESH:D051437 NCI:C4376 SNOMEDCT_US_2016_03_01:156092003 SNOMEDCT_US_2016_03_01:197656003 SNOMEDCT_US_2016_03_01:198524000 SNOMEDCT_US_2016_03_01:266553002 SNOMEDCT_US_2016_03_01:266616000 SNOMEDCT_US_2016_03_01:42399005 UMLS_CUI:C0035078 renal failure disease_ontology DOID:1074 PRISM. kidney failure DOID:10747 ICD9CM:204.2 SNOMEDCT_US_2016_03_01:154590001 SNOMEDCT_US_2016_03_01:188726003 SNOMEDCT_US_2016_03_01:190035004 SNOMEDCT_US_2016_03_01:33560006 SNOMEDCT_US_2016_03_01:95274002 UMLS_CUI:C0152271 subacute lymphoid leukemia disease_ontology DOID:10747 lymphoid leukemia DOID:10754 A otitis which involves inflammation of the middle ear. ICD10CM:H66.9 ICD10CM:H66.90 ICD9CM:382.9 MESH:D010033 NCI:C34885 SNOMEDCT_US_2016_03_01:155222006 SNOMEDCT_US_2016_03_01:194291009 SNOMEDCT_US_2016_03_01:267669008 SNOMEDCT_US_2016_03_01:65363002 UMLS_CUI:C0029882 disease_ontology DOID:10754 otitis media DOID:10762 ICD10CM:K76.6 ICD9CM:572.3 MESH:D006975 NCI:C3119 SNOMEDCT_US_2016_03_01:155821005 SNOMEDCT_US_2016_03_01:34742003 UMLS_CUI:C0020541 disease_ontology DOID:10762 portal hypertension DOID:10763 An artery disease characterized by chronic elevated blood pressure in the arteries. EFO:0000537 ICD10CM:I10 ICD10CM:I10-I15 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 SNOMEDCT_US_2016_03_01:155295004 SNOMEDCT_US_2016_03_01:155302005 SNOMEDCT_US_2016_03_01:194756002 SNOMEDCT_US_2016_03_01:194757006 SNOMEDCT_US_2016_03_01:194760004 SNOMEDCT_US_2016_03_01:194794002 SNOMEDCT_US_2016_03_01:195537001 SNOMEDCT_US_2016_03_01:266287006 SNOMEDCT_US_2016_03_01:38341003 UMLS_CUI:C0020538 HTN High blood pressure (& [essential hypertension]) hyperpiesia vascular hypertensive disorder disease_ontology hypertensive disease DOID:10763 hypertension DOID:10780 ICD10CM:D75.0 ICD9CM:289.6 MESH:C536842 NCI:C26955 OMIM:PS133100 SNOMEDCT_US_2016_03_01:154840005 SNOMEDCT_US_2016_03_01:17342003 SNOMEDCT_US_2016_03_01:267571003 UMLS_CUI:C0152264 Familiar Polycythemia familial erythrocytosis disease_ontology DOID:10780 primary polycythemia DOID:10782 ICD10CM:I88.0 ICD9CM:289.2 MESH:D008640 NCI:C26830 SNOMEDCT_US_2016_03_01:154837005 SNOMEDCT_US_2016_03_01:191376006 SNOMEDCT_US_2016_03_01:191378007 SNOMEDCT_US_2016_03_01:267548000 SNOMEDCT_US_2016_03_01:44897000 UMLS_CUI:C0025469 Mesenteric adenitis Mesenteric lymphadenitis Mesenteric lymphadenitis (disorder) disease_ontology DOID:10782 mesenteric lymphadenitis DOID:1080 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea. ICD10CM:B74 ICD10CM:B74.9 ICD9CM:125.9 MESH:D005368 NCI:C34611 SNOMEDCT_US_2016_03_01:105706003 SNOMEDCT_US_2016_03_01:187161002 SNOMEDCT_US_2016_03_01:187532008 SNOMEDCT_US_2016_03_01:50342004 UMLS_CUI:C0016085 disease due to superfamily Filarioidea (disorder) disease_ontology DOID:1080 filariasis DOID:10808 DOID:10807 DOID:10809 DOID:12047 DOID:12057 DOID:12068 DOID:12069 DOID:12806 DOID:13124 DOID:13125 DOID:241 DOID:242 ICD10CM:K25 ICD9CM:531 MESH:D013276 NCI:C3388 SNOMEDCT_US_2016_03_01:155681009 SNOMEDCT_US_2016_03_01:155690002 SNOMEDCT_US_2016_03_01:196627009 SNOMEDCT_US_2016_03_01:196642007 SNOMEDCT_US_2016_03_01:196649003 SNOMEDCT_US_2016_03_01:196650003 SNOMEDCT_US_2016_03_01:266436006 SNOMEDCT_US_2016_03_01:397825006 SNOMEDCT_US_2016_03_01:6034002 UMLS_CUI:C0038358 acute gastric ulcer with haemorrhage and perforation acute gastric ulcer with hemorrhage AND obstruction (disorder) acute gastric ulcer with hemorrhage AND perforation acute gastric ulcer with hemorrhage AND perforation (disorder) acute gastric ulcer with hemorrhage AND perforation [dup] (disorder) acute gastric ulcer with hemorrhage AND with perforation but without obstruction acute gastric ulcer with hemorrhage AND with perforation but without obstruction (disorder) acute gastric ulcer with hemorrhage and obstruction acute gastric ulcer with hemorrhage and perforation acute gastric ulcer with hemorrhage and perforation, with obstruction acute gastric ulcer with hemorrhage and perforation, without mention of obstruction acute gastric ulcer with hemorrhage, with obstruction acute gastric ulcer with hemorrhage, with perforation AND with obstruction (disorder) acute gastric ulcer with perforation acute gastric ulcer with perforation AND obstruction acute gastric ulcer with perforation AND obstruction (disorder) acute gastric ulcer with perforation, with obstruction acute gastric ulcer without hemorrhage and without perforation acute gastric ulcer without hemorrhage, without perforation AND without obstruction acute gastric ulcer without hemorrhage, without perforation AND without obstruction (disorder) acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction bleeding acute gastric ulcer chronic gastric ulcer without hemorrhage AND without perforation chronic gastric ulcer without hemorrhage AND without perforation but with obstruction chronic gastric ulcer without hemorrhage AND without perforation but with obstruction (disorder) chronic gastric ulcer without mention of hemorrhage or perforation, with obstruction disease_ontology DOID:10808 gastric ulcer DOID:10811 A respiratory system cancer that is located_in the nasal cavity. ICD10CM:C30.0 ICD9CM:160.0 NCI:C4918 SNOMEDCT_US_2016_03_01:187832001 SNOMEDCT_US_2016_03_01:363422006 SNOMEDCT_US_2016_03_01:93917007 UMLS_CUI:C0728864 malignant neoplasm of nasal cavities malignant tumor of the nasal cavity disease_ontology DOID:10811 nasal cavity cancer DOID:10816 A duodenum cancer that derives_from epithelial cells of glandular origin. NCI:C7889 SNOMEDCT_US_2016_03_01:408644002 UMLS_CUI:C0278804 Duodenal adenocarcinoma adenocarcinoma of duodenum (disorder) disease_ontology adenocarcinoma of duodenum DOID:10816 duodenum adenocarcinoma DOID:10825 A hypertension with no known cause. It is the most common type of hypertension. ICD10CM:I10 ICD9CM:401 ICD9CM:401.9 MESH:C562386 NCI:C3478 OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014 ORDO:243761 SNOMEDCT_US_2016_03_01:155296003 SNOMEDCT_US_2016_03_01:194757006 SNOMEDCT_US_2016_03_01:194760004 SNOMEDCT_US_2016_03_01:266228004 SNOMEDCT_US_2016_03_01:59621000 UMLS_CUI:C0085580 idiopathic hypertension primary hypertension disease_ontology DOID:10825 Xref MGI. OMIM mapping confirmed by DO. [SN]. essential hypertension DOID:10842 A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness. ICD10CM:A83.4 ICD9CM:062.4 SNOMEDCT_US_2016_03_01:66454007 UMLS_CUI:C0153066 Australian X disease Australian encephalitis disease_ontology DOID:10842 Murray Valley encephalitis DOID:10843 A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness. ICD10CM:A83.1 ICD9CM:062.1 MESH:D020241 NCI:C85227 SNOMEDCT_US_2016_03_01:47523006 UMLS_CUI:C0153064 disease_ontology WEE DOID:10843 Western equine encephalitis DOID:10845 A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis. ICD10CM:A83.3 ICD9CM:062.3 MESH:D004674 SNOMEDCT_US_2016_03_01:10429004 SNOMEDCT_US_2016_03_01:417192005 SNOMEDCT_US_2016_03_01:417607009 UMLS_CUI:C0014060 Neuroinvasive St. Louis encephalitis virus infection disease_ontology DOID:10845 St. Louis encephalitis DOID:1085 ICD10CM:Q91.3 ICD9CM:758.2 MESH:C580500 NCI:C101362 SNOMEDCT_US_2016_03_01:157022000 SNOMEDCT_US_2016_03_01:205626006 SNOMEDCT_US_2016_03_01:254265001 SNOMEDCT_US_2016_03_01:51500006 UMLS_CUI:C0152096 Complete trisomy 18 syndrome (disorder) E3 Trisomy trisomy 18 disease_ontology DOID:1085 OMIM mapping confirmed by DO. [LS]. Edwards syndrome DOID:10854 DOID:12898 ICD9CM:527.8 UMLS_CUI:C0029773 Non-neoplastic Salivary gland disease Salivary gland disease disease_ontology DOID:10854 salivary gland disease DOID:10863 ICD10CM:H49 ICD10CM:H49.9 ICD9CM:378.5 ICD9CM:378.50 SNOMEDCT_US_2016_03_01:12942001 SNOMEDCT_US_2016_03_01:194117002 SNOMEDCT_US_2016_03_01:194120005 SNOMEDCT_US_2016_03_01:400942002 UMLS_CUI:C0152221 Incomitant dissociation Paralytic strabismus disease_ontology DOID:10863 paralytic squint DOID:10871 A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision. EFO:0001365 ICD10CM:H35.30 ICD9CM:362.50 MESH:D008268 NCI:C84391 OMIM:PS603075 SNOMEDCT_US_2016_03_01:155112007 SNOMEDCT_US_2016_03_01:18222007 SNOMEDCT_US_2016_03_01:193384000 SNOMEDCT_US_2016_03_01:193385004 SNOMEDCT_US_2016_03_01:267718000 SNOMEDCT_US_2016_03_01:302891003 UMLS_CUI:C0242383 Senile macular degeneration Senile macular retinal degeneration age-related macular degeneration disease_ontology DOID:10871 OMIM mapping confirmed by DO. [SN]. age related macular degeneration DOID:10873 ICD10CM:H35.32 ICD9CM:362.52 SNOMEDCT_US_2016_03_01:11290001 SNOMEDCT_US_2016_03_01:16018000 SNOMEDCT_US_2016_03_01:414173003 UMLS_CUI:C0271084 Exudative senile macular degeneration of retina Neovascular age-related macular degeneration Senile macular degeneration, wet Wet senile macular retinal degeneration disease_ontology DOID:10873 Kuhnt-Junius degeneration DOID:1088 MESH:D008588 SNOMEDCT_US_2016_03_01:156890007 SNOMEDCT_US_2016_03_01:171131006 SNOMEDCT_US_2016_03_01:253121009 SNOMEDCT_US_2016_03_01:268308005 SNOMEDCT_US_2016_03_01:32941003 UMLS_CUI:C0025299 disease_ontology DOID:1088 meningocele DOID:10892 A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum. ICD10CM:Q54 ICD10CM:Q54.9 MESH:D007021 NCI:C40341 OMIM:146450 OMIM:300633 OMIM:300758 OMIM:300856 ORDO:440 SNOMEDCT_US_2016_03_01:416010008 UMLS_CUI:C0848558 familial hypospadias disease_ontology DOID:10892 Xref MGI. OMIM mapping confirmed by DO. [SN]. hypospadias DOID:10907 ICD10CM:Q02 ICD9CM:742.1 MESH:D008831 NCI:C85874 OMIM:251200 OMIM:604321 OMIM:604804 OMIM:608393 OMIM:608716 OMIM:612703 SNOMEDCT_US_2016_03_01:156893009 SNOMEDCT_US_2016_03_01:1829003 SNOMEDCT_US_2016_03_01:204030002 SNOMEDCT_US_2016_03_01:204031003 UMLS_CUI:C0025958 Microcephalus microencephaly disease_ontology DOID:10907 OMIM mapping confirmed by DO. [SN]. microcephaly DOID:10908 A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head. ICD10CM:G91 ICD10CM:G91.9 MESH:D006849 NCI:C3111 OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219 ORDO:2182 ORDO:2185 SNOMEDCT_US_2016_03_01:154995000 SNOMEDCT_US_2016_03_01:154997008 SNOMEDCT_US_2016_03_01:192807008 SNOMEDCT_US_2016_03_01:230745008 SNOMEDCT_US_2016_03_01:267687006 UMLS_CUI:C0020255 hydrocephalus, X-linked hydrocephalus, nonsyndromic, autosomal recessive disease_ontology DOID:10908 Xref MGI. OMIM mapping confirmed by DO. [SN]. hydrocephalus DOID:1091 MESH:D014076 SNOMEDCT_US_2016_03_01:155631000 SNOMEDCT_US_2016_03_01:234947003 SNOMEDCT_US_2016_03_01:266485001 SNOMEDCT_US_2016_03_01:367503003 SNOMEDCT_US_2016_03_01:72722003 UMLS_CUI:C0040435 dental disorder disease_ontology DOID:1091 tooth disease DOID:10914 A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information. DOID:4544 ICD10CM:R41.3 ICD9CM:294.0 MESH:D000647 NCI:C2867 SNOMEDCT_US_2016_03_01:162199006 SNOMEDCT_US_2016_03_01:247606008 SNOMEDCT_US_2016_03_01:3298001 SNOMEDCT_US_2016_03_01:386807006 SNOMEDCT_US_2016_03_01:48167000 SNOMEDCT_US_2016_03_01:78461004 UMLS_CUI:C0002622 UMLS_CUI:C0002625 Amnestic syndrome Korsakoff's psychosis or syndrome amnesia disease_ontology DOID:10914 amnestic disorder DOID:10915 MESH:D020915 NCI:C35764 NCI:C84803 OMIM:277730 SNOMEDCT_US_2016_03_01:154854002 SNOMEDCT_US_2016_03_01:191470004 SNOMEDCT_US_2016_03_01:191472007 SNOMEDCT_US_2016_03_01:268745002 SNOMEDCT_US_2016_03_01:69482004 UMLS_CUI:C0349464 Korsakoff Syndrome Korsakoff's psychosis (disorder) Korsakoff's syndrome Korsakov psychosis Korsakov's psychosis disease_ontology DOID:10915 OMIM mapping confirmed by DO. [LS]. Wernicke-Korsakoff syndrome DOID:10919 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex. ICD9CM:302.50 SNOMEDCT_US_2016_03_01:191782007 UMLS_CUI:C0040630 disease_ontology DOID:10919 transsexualism DOID:10923 DOID:12924 DOID:13024 ICD10CM:D57 ICD10CM:D57.1 ICD10CM:D57.2 ICD10CM:D57.20 ICD9CM:282.6 ICD9CM:282.60 ICD9CM:282.63 MESH:D000755 MESH:D006450 NCI:C34383 NCI:C34676 OMIM:603903 SNOMEDCT_US_2016_03_01:127040003 SNOMEDCT_US_2016_03_01:154798006 SNOMEDCT_US_2016_03_01:191194009 SNOMEDCT_US_2016_03_01:191195005 SNOMEDCT_US_2016_03_01:191199004 SNOMEDCT_US_2016_03_01:276267006 SNOMEDCT_US_2016_03_01:35434009 SNOMEDCT_US_2016_03_01:417357006 SNOMEDCT_US_2016_03_01:80046004 UMLS_CUI:C0002895 UMLS_CUI:C0019034 Hb SC disease Hb-S/Hb-C disease Hb-SS disease without crisis Hemoglobin S disease without crisis (disorder) Sickle-cell/Hb-C disease without crisis drepanocytosis hemoglobin SC disease disease_ontology DOID:10923 OMIM mapping confirmed by DO. [LS]. sickle cell anemia DOID:10933 An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions). ICD10CM:F42 ICD9CM:300.3 MESH:D009771 NCI:C88411 SNOMEDCT_US_2016_03_01:191736004 SNOMEDCT_US_2016_03_01:191739006 SNOMEDCT_US_2016_03_01:192406007 SNOMEDCT_US_2016_03_01:192411009 SNOMEDCT_US_2016_03_01:71478004 UMLS_CUI:C0028768 Anancastic neurosis obsessive compulsive disorder disease_ontology DOID:10933 obsessive-compulsive disorder DOID:10937 A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others. ICD10CM:F63.9 ICD9CM:312.30 MESH:D007174 NCI:C34723 SNOMEDCT_US_2016_03_01:192095006 SNOMEDCT_US_2016_03_01:192098008 SNOMEDCT_US_2016_03_01:66347000 UMLS_CUI:C0021122 disease_ontology DOID:10937 impulse control disorder DOID:10939 A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. ICD10CM:F60.2 ICD9CM:301.7 MESH:D000987 NCI:C88413 SNOMEDCT_US_2016_03_01:191769004 SNOMEDCT_US_2016_03_01:191777000 SNOMEDCT_US_2016_03_01:192487000 SNOMEDCT_US_2016_03_01:26665006 SNOMEDCT_US_2016_03_01:268759009 UMLS_CUI:C0003431 Asocial personality Dissocial personality disorder Psychopath.personality Psychopathic personality Psychopathic personality disorder sociopathic personality disease_ontology DOID:10939 antisocial personality disorder DOID:1094 A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone" and symptoms starting before seven years of age. DOID:1093 EFO:0003888 ICD9CM:314.8 MESH:D001289 NCI:C35092 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 OMIM:613003 UMLS_CUI:C0041671 UMLS_CUI:C0154629 ADHD attention deficit disorder hyperkinetic disorder disease_ontology DOID:1094 Xref MGI. attention deficit hyperactivity disorder DOID:10941 EFO:0003870 MESH:D002532 NCI:C34458 SNOMEDCT_US_2016_03_01:128609009 SNOMEDCT_US_2016_03_01:42994005 UMLS_CUI:C0007766 brain aneurysm disease_ontology DOID:10941 intracranial aneurysm DOID:10944 ICD10CM:K14 ICD10CM:K14.9 ICD9CM:529.9 MESH:D014060 SNOMEDCT_US_2016_03_01:155533008 SNOMEDCT_US_2016_03_01:155665004 SNOMEDCT_US_2016_03_01:155667007 SNOMEDCT_US_2016_03_01:196595001 SNOMEDCT_US_2016_03_01:266496009 SNOMEDCT_US_2016_03_01:69244009 UMLS_CUI:C0040409 disease_ontology DOID:10944 tongue disease DOID:10952 A kidney disease that is characterized by an inflammation of the kidneys. ICD10CM:N05 ICD10CM:N08 MESH:D009393 NCI:C26833 SNOMEDCT_US_2016_03_01:155853001 SNOMEDCT_US_2016_03_01:266615001 SNOMEDCT_US_2016_03_01:274107001 SNOMEDCT_US_2016_03_01:52845002 UMLS_CUI:C0027697 disease_ontology DOID:10952 nephritis DOID:10955 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis. DOID:0050008 ICD10CM:B78 ICD10CM:B78.9 ICD9CM:127.2 MESH:D013322 SNOMEDCT_US_2016_03_01:1214006 SNOMEDCT_US_2016_03_01:187177001 SNOMEDCT_US_2016_03_01:187537002 UMLS_CUI:C0038463 Infection by Strongyloides (disorder) disseminated strongyloidiasis disease_ontology DOID:10955 strongyloidiasis DOID:10969 ICD9CM:343.4 MESH:D006429 SNOMEDCT_US_2016_03_01:155024003 SNOMEDCT_US_2016_03_01:155025002 SNOMEDCT_US_2016_03_01:155026001 SNOMEDCT_US_2016_03_01:1593000 SNOMEDCT_US_2016_03_01:192952005 SNOMEDCT_US_2016_03_01:192955007 SNOMEDCT_US_2016_03_01:267696006 UMLS_CUI:C0392550 Infantile hemiplegia Postnatal infantile hemiplegia disease_ontology DOID:10969 hemiplegia DOID:10976 EFO:0004254 ICD10CM:N03.2 MESH:D015433 NCI:C34645 SNOMEDCT_US_2016_03_01:197710000 SNOMEDCT_US_2016_03_01:77182004 UMLS_CUI:C0017665 membranous nephropathy disease_ontology DOID:10976 membranous glomerulonephritis DOID:10997 ICD10CM:H25.09 SNOMEDCT_US_2016_03_01:193584004 SNOMEDCT_US_2016_03_01:52421005 UMLS_CUI:C0271163 Incipient cataract Incipient senile cataract Water clefts disease_ontology DOID:10997 immature cataract DOID:110 ICD10CM:H25-H28 ICD10CM:H27.9 MESH:D007905 NCI:C26812 SNOMEDCT_US_2016_03_01:10810001 SNOMEDCT_US_2016_03_01:194158009 SNOMEDCT_US_2016_03_01:194613002 UMLS_CUI:C0023308 disease_ontology DOID:110 lens disease DOID:1100 MESH:D010049 NCI:C26841 SNOMEDCT_US_2016_03_01:5552004 UMLS_CUI:C0029928 disease_ontology DOID:1100 ovarian disease DOID:11030 ICD10CM:H18.20 ICD9CM:371.2 ICD9CM:371.20 MESH:D015715 NCI:C50508 SNOMEDCT_US_2016_03_01:155158008 SNOMEDCT_US_2016_03_01:193811006 SNOMEDCT_US_2016_03_01:193812004 SNOMEDCT_US_2016_03_01:193817005 SNOMEDCT_US_2016_03_01:27194006 UMLS_CUI:C0010037 Corneal oedema disease_ontology DOID:11030 corneal edema DOID:11031 ICD10CM:H18.1 ICD9CM:371.23 NCI:C26970 SNOMEDCT_US_2016_03_01:193815002 SNOMEDCT_US_2016_03_01:57207003 UMLS_CUI:C0155111 disease_ontology DOID:11031 bullous keratopathy DOID:11044 ICD10CM:Q79.3 ICD9CM:756.73 MESH:D020139 NCI:C84725 OMIM:230750 SNOMEDCT_US_2016_03_01:72951007 UMLS_CUI:C0265706 disease_ontology DOID:11044 OMIM mapping confirmed by DO. [SN]. gastroschisis DOID:11049 ICD10CM:P24.0 ICD10CM:P24.00 ICD10CM:P24.01 MESH:D008471 NCI:C87093 SNOMEDCT_US_2016_03_01:14608006 SNOMEDCT_US_2016_03_01:157110000 SNOMEDCT_US_2016_03_01:206292002 SNOMEDCT_US_2016_03_01:278927005 SNOMEDCT_US_2016_03_01:85779008 UMLS_CUI:C0025048 Neonatal aspiration of meconium meconium aspiration disease_ontology DOID:11049 meconium aspiration syndrome DOID:11054 An urinary system cancer that results_in malignant growth located_in the urinary bladder. DOID:5428 ICD10CM:C67 ICD10CM:C67.9 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 SNOMEDCT_US_2016_03_01:126885006 SNOMEDCT_US_2016_03_01:154540000 SNOMEDCT_US_2016_03_01:188248005 SNOMEDCT_US_2016_03_01:269607003 SNOMEDCT_US_2016_03_01:363455001 SNOMEDCT_US_2016_03_01:399326009 SNOMEDCT_US_2016_03_01:93689003 UMLS_CUI:C0005684 UMLS_CUI:C0005695 bladder cancer tumor of the bladder disease_ontology DOID:11054 OMIM mapping confirmed by DO. [SN]. urinary bladder cancer DOID:11060 A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix. ICD10CM:O44 MESH:D010923 NCI:C26858 SNOMEDCT_US_2016_03_01:157059004 SNOMEDCT_US_2016_03_01:198930005 SNOMEDCT_US_2016_03_01:36813001 UMLS_CUI:C0032046 disease_ontology DOID:11060 placenta praevia DOID:1107 A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. EFO:0002916 NCI:C3513 SNOMEDCT_US_2016_03_01:154441003 SNOMEDCT_US_2016_03_01:255079005 SNOMEDCT_US_2016_03_01:372138000 SNOMEDCT_US_2016_03_01:93785002 UMLS_CUI:C0152018 cancer of esophagus cancer of oesophagus carcinoma OF ESOPHAGUS carcinoma of esophagus (disorder) carcinoma of oesophagus disease_ontology DOID:1107 esophageal carcinoma DOID:11077 A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue. DOID:0050060 ICD10CM:A23 ICD10CM:A23.9 ICD9CM:023 ICD9CM:023.9 MESH:D002006 NCI:C84602 SNOMEDCT_US_2016_03_01:111804008 SNOMEDCT_US_2016_03_01:154296006 SNOMEDCT_US_2016_03_01:186310006 SNOMEDCT_US_2016_03_01:187304000 SNOMEDCT_US_2016_03_01:75702008 UMLS_CUI:C0006309 Maltese fever undulant fever disease_ontology Bang's disease Gibraltar fever Malta fever Mediterranean fever DOID:11077 brucellosis DOID:11080 A parasitic ectoparasitic infectious disease that is caused by parasitic dipterous fly larvae (maggots) feeding on the host's necrotic or living tissue. ICD10CM:B87 ICD10CM:B87.9 ICD9CM:134.0 MESH:D009198 SNOMEDCT_US_2016_03_01:154423006 SNOMEDCT_US_2016_03_01:187224004 SNOMEDCT_US_2016_03_01:187547004 SNOMEDCT_US_2016_03_01:266225001 SNOMEDCT_US_2016_03_01:60412004 UMLS_CUI:C0027030 Infestation by fly larvae (disorder) Infestation by maggots Maggot infestation Myiasis, unspecified Myiasis, unspecified (disorder) disease_ontology DOID:11080 myiasis DOID:11102 A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella. ICD10CM:A44 ICD10CM:A44.9 ICD9CM:088.0 MESH:D001474 NCI:C84586 SNOMEDCT_US_2016_03_01:17116008 SNOMEDCT_US_2016_03_01:186824002 SNOMEDCT_US_2016_03_01:187340003 SNOMEDCT_US_2016_03_01:240454008 SNOMEDCT_US_2016_03_01:240623002 SNOMEDCT_US_2016_03_01:266123003 UMLS_CUI:C0004771 Bartonella infectious disease Rochalimaea infection (disorder) bartonelliasis disease_ontology DOID:11102 bartonellosis DOID:11104 A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite. ICD10CM:A77 ICD10CM:A77.9 ICD9CM:082.0 SNOMEDCT_US_2016_03_01:186771002 SNOMEDCT_US_2016_03_01:186773004 SNOMEDCT_US_2016_03_01:187385002 UMLS_CUI:C0038041 Spotted fever group rickettsial disease (disorder) disease_ontology DOID:11104 spotted fever DOID:11105 A fundus dystrophy that is characterized by discrete uniform white dots over the entire fundus with greatest density in the midperiphery and no macular involvement. ICD10CM:H35.52 ICD9CM:362.74 MESH:C562733 OMIM:136880 SNOMEDCT_US_2016_03_01:68222009 UMLS_CUI:C0311338 Pigmentary retinal dystrophy retinitis punctata albescens disease_ontology DOID:11105 OMIM mapping confirmed by DO. [SN]. fundus albipunctatus DOID:11111 ICD10CM:N13.30 ICD9CM:591 MESH:D006869 NCI:C26796 SNOMEDCT_US_2016_03_01:155866001 SNOMEDCT_US_2016_03_01:197791000 SNOMEDCT_US_2016_03_01:43064006 UMLS_CUI:C0020295 disease_ontology DOID:11111 hydronephrosis DOID:11119 A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year. EFO:0004895 ICD10CM:F95.2 ICD9CM:307.23 MESH:D005879 NCI:C35078 OMIM:137580 SNOMEDCT_US_2016_03_01:154936002 SNOMEDCT_US_2016_03_01:192624004 SNOMEDCT_US_2016_03_01:268778009 SNOMEDCT_US_2016_03_01:39098006 SNOMEDCT_US_2016_03_01:5158005 UMLS_CUI:C0040517 Guinon's disease Psychogenic tics Tourette syndrome motor-verbal tic disorder disease_ontology DOID:11119 OMIM mapping confirmed by DO. [SN]. Gilles de la Tourette syndrome DOID:11121 ICD10CM:K04.0 ICD9CM:522.0 MESH:D011671 NCI:C52595 SNOMEDCT_US_2016_03_01:155638006 SNOMEDCT_US_2016_03_01:196331007 SNOMEDCT_US_2016_03_01:32620007 UMLS_CUI:C0034103 disease_ontology DOID:11121 pulpitis DOID:11130 ICD10CM:I15 ICD10CM:I15.9 ICD9CM:405 ICD9CM:405.9 NCI:C3657 SNOMEDCT_US_2016_03_01:155300002 SNOMEDCT_US_2016_03_01:194789002 SNOMEDCT_US_2016_03_01:194792003 SNOMEDCT_US_2016_03_01:31992008 UMLS_CUI:C0155616 disease_ontology DOID:11130 secondary hypertension DOID:11132 disease_ontology DOID:11132 prostatic hypertrophy DOID:1115 A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from embryonic mesoderm. DOID:3936 ICD10CM:C49 ICD9CM:171 ICD9CM:171.9 SNOMEDCT_US_2016_03_01:187985009 SNOMEDCT_US_2016_03_01:93765001 UMLS_CUI:C0153519 connective and soft tissue neoplasm tumor of soft tissue and skeleton disease_ontology DOID:1115 sarcoma DOID:11151 MESH:D041761 NCI:C34443 SNOMEDCT_US_2016_03_01:197376000 SNOMEDCT_US_2016_03_01:235919008 SNOMEDCT_US_2016_03_01:266541001 SNOMEDCT_US_2016_03_01:44900007 UMLS_CUI:C0947622 disease_ontology DOID:11151 cholecystolithiasis DOID:11153 ICD10CM:L74.0 ICD10CM:L74.2 ICD9CM:705.1 MESH:D008883 SNOMEDCT_US_2016_03_01:156415007 SNOMEDCT_US_2016_03_01:201190003 SNOMEDCT_US_2016_03_01:201194007 SNOMEDCT_US_2016_03_01:201197000 SNOMEDCT_US_2016_03_01:267813002 SNOMEDCT_US_2016_03_01:44279002 SNOMEDCT_US_2016_03_01:72658003 UMLS_CUI:C0162423 Miliaria crystallina Prickly heat - miliaria Sudamina disease_ontology DOID:11153 miliaria rubra DOID:11155 ICD10CM:L74.4 MESH:D007007 NCI:C34718 SNOMEDCT_US_2016_03_01:201189007 SNOMEDCT_US_2016_03_01:45004005 UMLS_CUI:C0020620 Hypohidrosis (disorder) Oligohidrosis disease_ontology DOID:11155 hypohidrosis DOID:11156 ICD10CM:L74.4 ICD9CM:705.0 MESH:D007007 NCI:C34385 OMIM:206600 SNOMEDCT_US_2016_03_01:14662005 SNOMEDCT_US_2016_03_01:156414006 SNOMEDCT_US_2016_03_01:201189007 SNOMEDCT_US_2016_03_01:39659002 UMLS_CUI:C0003028 Adiaphoresis absence of sweating disease_ontology DOID:11156 OMIM mapping confirmed by DO. [SN]. anhidrosis DOID:1116 A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop). DOID:11333 DOID:11751 KEGG:05133 MESH:D001885 MESH:D014917 SNOMEDCT_US_2016_03_01:26484003 UMLS_CUI:C0006015 WC - Whooping cough bordetella infection whooping cough disease_ontology DOID:1116 pertussis DOID:11162 A lung disease characterized by inadequate gas exchange by the respiratory system. DOID:11391 DOID:11392 DOID:11393 ICD10CM:J96.0 ICD9CM:518.81 NCI:C27043 SNOMEDCT_US_2016_03_01:65710008 UMLS_CUI:C0264490 acute and chronic respiratory failure acute respiratory Failure acute-on-chronic respiratory failure chronic respiratory failure respiratory insufficiency/failure disease_ontology DOID:11162 respiratory failure DOID:11168 A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts. DOID:7877 ICD10CM:A63.0 ICD9CM:078.11 MESH:D003218 NCI:C2960 NCI:C4820 SNOMEDCT_US_2016_03_01:123157002 SNOMEDCT_US_2016_03_01:154361008 SNOMEDCT_US_2016_03_01:154365004 SNOMEDCT_US_2016_03_01:186688003 SNOMEDCT_US_2016_03_01:22020001 SNOMEDCT_US_2016_03_01:240542006 SNOMEDCT_US_2016_03_01:266113007 SNOMEDCT_US_2016_03_01:266198004 SNOMEDCT_US_2016_03_01:302812006 UMLS_CUI:C0009663 UMLS_CUI:C0554632 Anogenital Human papilloma Virus Infectious Disease Anogenital warts Genital warts genital wart virus infectious disease venereal wart disease_ontology Condyloma acuminatum DOID:11168 anogenital venereal wart DOID:11175 ICD10CM:H05.4 ICD10CM:H05.40 ICD9CM:376.5 ICD9CM:376.50 MESH:D015841 NCI:C79552 SNOMEDCT_US_2016_03_01:155200004 SNOMEDCT_US_2016_03_01:194031000 SNOMEDCT_US_2016_03_01:267746003 SNOMEDCT_US_2016_03_01:80093006 UMLS_CUI:C0014306 disease_ontology DOID:11175 enophthalmos DOID:11184 ICD10CM:H10.02 ICD9CM:372.03 UMLS_CUI:C0029668 disease_ontology DOID:11184 acute conjunctivitis DOID:11193 A synostosis that results_in the fusion of two or more digits. ICD10CM:Q70 ICD10CM:Q70.9 ICD9CM:755.1 MESH:D013576 NCI:C87125 OMIM:185900 OMIM:186100 OMIM:186200 OMIM:186300 ORDO:295012 ORDO:90025 ORDO:93402 ORDO:93403 ORDO:93404 ORDO:93406 SNOMEDCT_US_2016_03_01:111313001 SNOMEDCT_US_2016_03_01:156989004 SNOMEDCT_US_2016_03_01:205151006 SNOMEDCT_US_2016_03_01:253975004 SNOMEDCT_US_2016_03_01:268252004 SNOMEDCT_US_2016_03_01:373413006 SNOMEDCT_US_2016_03_01:75352001 UMLS_CUI:C0039075 chromosome 2q35 duplication syndrome symphalangism symphalangy webbing of digits disease_ontology DOID:11193 Xref MGI. syndactyly DOID:11199 A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood. ICD10CM:E20 ICD10CM:E20.9 ICD9CM:252.1 MESH:D007011 NCI:C78350 OMIM:146200 OMIM:307700 ORDO:2238 SNOMEDCT_US_2016_03_01:154697005 SNOMEDCT_US_2016_03_01:190457001 SNOMEDCT_US_2016_03_01:267479004 SNOMEDCT_US_2016_03_01:36976004 UMLS_CUI:C0020626 disease_ontology DOID:11199 Xref MGI. hypoparathyroidism DOID:112 DOID:111 DOID:13536 DOID:14031 ICD10CM:I85.01 ICD9CM:456.0 ICD9CM:456.2 ICD9CM:456.20 NCI:C78282 SNOMEDCT_US_2016_03_01:17709002 SNOMEDCT_US_2016_03_01:195474004 SNOMEDCT_US_2016_03_01:195475003 SNOMEDCT_US_2016_03_01:195479009 SNOMEDCT_US_2016_03_01:195643006 SNOMEDCT_US_2016_03_01:236067006 UMLS_CUI:C0155789 UMLS_CUI:C0155791 UMLS_CUI:C0155792 Bleeding esophageal varices Bleeding esophageal varices (disorder) Bleeding oesophageal varices esophageal varices esophageal varices in disease classified elsewhere, with bleeding esophageal varices with bleeding esophageal varices with bleeding in disease EC (disorder) esophageal varices without bleeding esophageal varices without bleeding (disorder) esophageal varices without mention of bleeding disease_ontology DOID:112 esophageal varix DOID:11200 NCI:C27872 UMLS_CUI:C1333147 disease_ontology DOID:11200 T cell deficiency DOID:11201 An endocrine system disease that is located_in the parathyroid gland. ICD10CM:E21.5 ICD9CM:252 ICD9CM:252.9 MESH:D010279 NCI:C26844 SNOMEDCT_US_2016_03_01:190462000 SNOMEDCT_US_2016_03_01:267478007 SNOMEDCT_US_2016_03_01:73132005 UMLS_CUI:C0030517 disease of parathyroid glands disease_ontology DOID:11201 parathyroid gland disease DOID:11202 DOID:14790 ICD10CM:E21.0 ICD9CM:252.01 MESH:D049950 NCI:C48280 OMIM:600166 ORDO:99878 SNOMEDCT_US_2016_03_01:190452007 SNOMEDCT_US_2016_03_01:237653008 SNOMEDCT_US_2016_03_01:36348003 SNOMEDCT_US_2016_03_01:54920000 UMLS_CUI:C0221002 UMLS_CUI:C0271846 familial benign hypercalcemia (disorder) familial primary hyperparathyroidism primary hyperparathyroidism (disorder) disease_ontology DOID:11202 Xref MGI. primary hyperparathyroidism DOID:11204 A chronic conjunctivitis that is an inflammation of the conjunctiva involing red, itchy, and watery eyes a resulting from an exposure to an allergen or an irritant. MESH:D003233 NCI:C34506 SNOMEDCT_US_2016_03_01:155168003 SNOMEDCT_US_2016_03_01:193868008 SNOMEDCT_US_2016_03_01:20212001 SNOMEDCT_US_2016_03_01:231854006 SNOMEDCT_US_2016_03_01:473460002 UMLS_CUI:C0009766 disease_ontology DOID:11204 allergic conjunctivitis DOID:11206 A substance abuse that involves the recurring use of opioid drugs despite negative consequences. ICD10CM:F11.1 ICD9CM:305.5 SNOMEDCT_US_2016_03_01:5602001 UMLS_CUI:C0029095 disease_ontology DOID:11206 opioid abuse DOID:11213 NCI:C35704 SNOMEDCT_US_2016_03_01:155162002 SNOMEDCT_US_2016_03_01:17482009 SNOMEDCT_US_2016_03_01:240066005 SNOMEDCT_US_2016_03_01:267734002 SNOMEDCT_US_2016_03_01:399047004 SNOMEDCT_US_2016_03_01:399219006 UMLS_CUI:C1313983 Contagious opthalmia Pink eye Pinkeye disease_ontology DOID:11213 acute contagious conjunctivitis DOID:11227 A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis. ICD9CM:077.4 MESH:D003232 NCI:C34505 SNOMEDCT_US_2016_03_01:186677009 SNOMEDCT_US_2016_03_01:31502007 SNOMEDCT_US_2016_03_01:398264003 SNOMEDCT_US_2016_03_01:398273006 UMLS_CUI:C0009765 Apollo disease Epidemic hemorrhagic conjunctivitis disease_ontology viral conjunctivitis DOID:11227 acute hemorrhagic conjunctivitis DOID:1123 MESH:D025242 OMIM:106300 SNOMEDCT_US_2016_03_01:357182002 SNOMEDCT_US_2016_03_01:359173000 SNOMEDCT_US_2016_03_01:372109003 SNOMEDCT_US_2016_03_01:8847002 UMLS_CUI:C0949691 spondarthropathy spondylarthrosis disease_ontology DOID:1123 spondyloarthropathy DOID:11247 ICD10CM:D65 ICD9CM:286.6 MESH:D004211 NCI:C2992 SNOMEDCT_US_2016_03_01:267563002 SNOMEDCT_US_2016_03_01:67406007 UMLS_CUI:C0012739 DIC Defibrination syndrome Diffuse or disseminated intravascular coagulation disease_ontology DOID:11247 disseminated intravascular coagulation DOID:11249 ICD10CM:E56.1 ICD9CM:269.0 MESH:D014813 NCI:C99108 SNOMEDCT_US_2016_03_01:124892003 SNOMEDCT_US_2016_03_01:52675005 UMLS_CUI:C0042880 deficiency of vitamin K deficiency of vitamin K (disorder) vitamin K deficiency vitamin K deficiency (disorder) disease_ontology DOID:11249 vitamin K deficiency hemorrhagic disease DOID:11256 A primary bacterial infectious disease that refers to a group of diseases, located_in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted_by lice, transmitted_by fleas, and transmitted_by mites. DOID:11255 DOID:12353 ICD10CM:A75 ICD10CM:A75.0 ICD10CM:A75.2 ICD10CM:A75.9 ICD9CM:080 ICD9CM:081.0 ICD9CM:081.9 MESH:D014437 MESH:D014438 NCI:C84688 NCI:C84689 SNOMEDCT_US_2016_03_01:154375001 SNOMEDCT_US_2016_03_01:187383009 SNOMEDCT_US_2016_03_01:25668000 SNOMEDCT_US_2016_03_01:266205000 SNOMEDCT_US_2016_03_01:39111003 SNOMEDCT_US_2016_03_01:414263007 SNOMEDCT_US_2016_03_01:83838002 UMLS_CUI:C0041471 UMLS_CUI:C0041472 UMLS_CUI:C0041473 Endemic Typhus fever Exanthematic Typhus fever Flea typhus Louse-borne [epidemic] typhus Murine [endemic] typhus Typhus fever endemic flea-borne typhus epidemic louse-borne typhus disease_ontology Classical typhus (fever) Epidemic (louse-borne) typhus Epidemic louse-borne typhus fever due to Rickettsia prowazekii European typhus Exanthematous typhus Famine fever Flea-borne rickettsiosis Flea-borne typhus Hospital fever Jail fever Louse-borne rickettsiosis Louse-borne typhus Mexican typhus Moscow typhus Murine typhus Petechial fever Prison fever Rat flea typhus Ship fever Shop typhus Typhus exanthematique Urban typhus DOID:11256 typhus DOID:11260 A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis. ICD10CM:A82 ICD10CM:A82.9 ICD9CM:071 MESH:D011818 NCI:C28182 SNOMEDCT_US_2016_03_01:14168008 SNOMEDCT_US_2016_03_01:186644005 SNOMEDCT_US_2016_03_01:187393002 SNOMEDCT_US_2016_03_01:275370001 UMLS_CUI:C0034494 Lyssa disease_ontology DOID:11260 rabies DOID:11262 A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia. ICD10CM:A70 ICD9CM:073 ICD9CM:073.9 MESH:D009956 NCI:C34873 SNOMEDCT_US_2016_03_01:154367007 SNOMEDCT_US_2016_03_01:154369005 SNOMEDCT_US_2016_03_01:186653003 SNOMEDCT_US_2016_03_01:186657002 SNOMEDCT_US_2016_03_01:266200005 SNOMEDCT_US_2016_03_01:75116005 UMLS_CUI:C0029291 psittacosis disease_ontology DOID:11262 ornithosis DOID:11266 A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure. ICD10CM:A98.5 ICD9CM:078.6 MESH:D006480 NCI:C84753 SNOMEDCT_US_2016_03_01:102455002 SNOMEDCT_US_2016_03_01:186701001 SNOMEDCT_US_2016_03_01:364756009 SNOMEDCT_US_2016_03_01:70826003 UMLS_CUI:C0019101 HFRS Hemorrhagic fever, Russian Hemorrhagic nephrosonephritis Puumala virus nephropathy (disorder) disease_ontology DOID:11266 hemorrhagic fever with renal syndrome DOID:11267 ICD10CM:H18.44 ICD9CM:371.45 MESH:C536156 SNOMEDCT_US_2016_03_01:193827004 SNOMEDCT_US_2016_03_01:85149007 UMLS_CUI:C0152455 disease_ontology DOID:11267 keratomalacia DOID:11277 ICD10CM:E05.2 ICD9CM:242.3 NCI:C35171 SNOMEDCT_US_2016_03_01:190250001 SNOMEDCT_US_2016_03_01:190254005 SNOMEDCT_US_2016_03_01:57777000 UMLS_CUI:C0342127 Plummer disease Toxic nodular Goiter Toxic nodular goiter (disorder) Toxic nodular goiter NOS (disorder) Toxic nodular goiter unspecified (disorder) disease_ontology DOID:11277 Plummer's disease DOID:11294 An anomalous configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system. CSP:0571-2717 HP:0100026 ICD10CM:I77.0 NCI:C2882 SNOMEDCT_US_2016_03_01:11071001 SNOMEDCT_US_2016_03_01:14156004 SNOMEDCT_US_2016_03_01:204480002 SNOMEDCT_US_2016_03_01:233982006 SNOMEDCT_US_2016_03_01:403966009 UMLS_CUI:C0334533 Arteriovenous hemangioma (disorder) Cirsoid aneurysm Racemose Angioma Racemose aneurysm (morphologic abnormality) Racemose hemangioma (morphologic abnormality) disease_ontology DOID:11294 arteriovenous malformation DOID:11320 A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems. ICD10CM:A98.2 ICD9CM:065.2 MESH:D007733 SNOMEDCT_US_2016_03_01:23097003 UMLS_CUI:C0022810 disease_ontology DOID:11320 Kyasanur forest disease DOID:11328 A psychotic disorder that involves schizophrenia symptoms over time period of one month. ICD10CM:F20.81 ICD9CM:295.4 MESH:D011618 NCI:C94376 SNOMEDCT_US_2016_03_01:88975006 UMLS_CUI:C0036358 disease_ontology DOID:11328 schizophreniform disorder DOID:11335 A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs. ICD10CM:D80-D89 ICD10CM:D86 ICD10CM:D86.9 ICD9CM:135 MESH:D012507 NCI:C34995 OMIM:181000 OMIM:612387 OMIM:612388 ORDO:797 SNOMEDCT_US_2016_03_01:154425004 SNOMEDCT_US_2016_03_01:31541009 UMLS_CUI:C0036202 Boeck sarcoid lymphogranulomatosis disease_ontology DOID:11335 sarcoidosis DOID:11338 A primary bacterial infectious disease that results_in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli. ICD10CM:A35 ICD9CM:037 MESH:D013742 NCI:C85185 SNOMEDCT_US_2016_03_01:154312006 SNOMEDCT_US_2016_03_01:276202003 SNOMEDCT_US_2016_03_01:76902006 UMLS_CUI:C0039614 Infection due to Clostridium tetani clostridial tetanus disease_ontology DOID:11338 tetanus DOID:1134 DOID:1133 DOID:13280 DOID:13901 DOID:2405 ICD10CM:K06.0 ICD9CM:523.2 ICD9CM:523.20 ICD9CM:523.21 ICD9CM:523.22 ICD9CM:523.23 ICD9CM:523.24 MESH:D005889 NCI:C82068 SNOMEDCT_US_2016_03_01:155645006 SNOMEDCT_US_2016_03_01:196360003 SNOMEDCT_US_2016_03_01:4356008 SNOMEDCT_US_2016_03_01:59898000 UMLS_CUI:C0017572 UMLS_CUI:C0266916 UMLS_CUI:C1456171 UMLS_CUI:C1456172 UMLS_CUI:C1456173 Gingival recession Gingival recession (disorder) Gingival recession NOS (disorder) Gingival recession, localized Gingival recession, unspecified localized gingival recession localized gingival recession (disorder) minimal gingival recession moderate gingival recession severe gingival recession disease_ontology DOID:1134 gingival recession DOID:11353 ICD10CM:N32.3 ICD9CM:596.3 MESH:C562406 OMIM:109820 SNOMEDCT_US_2016_03_01:155888001 SNOMEDCT_US_2016_03_01:156977001 SNOMEDCT_US_2016_03_01:197866008 SNOMEDCT_US_2016_03_01:197869001 SNOMEDCT_US_2016_03_01:21853005 SNOMEDCT_US_2016_03_01:252004007 SNOMEDCT_US_2016_03_01:268335001 UMLS_CUI:C0156273 Diverticulum - bladder Diverticulum of bladder disease_ontology DOID:11353 OMIM mapping confirmed by DO. [SN]. bladder diverticulum DOID:11372 A colonic disease that is characterized by an abnormal dilation of the colon. DOID:1771 ICD10CM:K59.3 MESH:D008531 NCI:C34810 SNOMEDCT_US_2016_03_01:197138002 SNOMEDCT_US_2016_03_01:197144003 SNOMEDCT_US_2016_03_01:33995003 UMLS_CUI:C0025160 Dilatation of colon disease_ontology DOID:11372 megacolon DOID:11379 A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis. ICD10CM:B83.1 ICD9CM:128.1 MESH:D058429 SNOMEDCT_US_2016_03_01:44086001 UMLS_CUI:C0018013 Gnathostomiasis Infectious Disease by Gnathostoma (disorder) disease_ontology DOID:11379 gnathomiasis DOID:11383 ICD10CM:Q53.9 ICD9CM:752.51 MESH:D003456 NCI:C12326 OMIM:219050 SNOMEDCT_US_2016_03_01:156967003 SNOMEDCT_US_2016_03_01:204878001 SNOMEDCT_US_2016_03_01:204879009 SNOMEDCT_US_2016_03_01:204882004 SNOMEDCT_US_2016_03_01:268226005 SNOMEDCT_US_2016_03_01:367721002 SNOMEDCT_US_2016_03_01:37501009 UMLS_CUI:C0010417 Cryptorchism Undescended testicle Undescended testis undescended testicles disease_ontology DOID:11383 OMIM mapping confirmed by DO. [SN]. cryptorchidism DOID:11389 MESH:D013354 SNOMEDCT_US_2016_03_01:37660004 UMLS_CUI:C0038539 Subdural abscess (disorder) disease_ontology DOID:11389 subdural empyema DOID:11394 A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia. ICD10CM:J80 MESH:D012128 NCI:C3353 SNOMEDCT_US_2016_03_01:155627006 SNOMEDCT_US_2016_03_01:196150004 SNOMEDCT_US_2016_03_01:196154008 SNOMEDCT_US_2016_03_01:206281003 SNOMEDCT_US_2016_03_01:266411000 SNOMEDCT_US_2016_03_01:67782005 UMLS_CUI:C0035222 ARDS Non-cardiogenic pulmonary edema Shock lung adult RDS disease_ontology DOID:11394 PRISM. adult respiratory distress syndrome DOID:11396 DOID:13472 ICD10CM:J81 ICD10CM:J81.1 MESH:D011654 NCI:C26868 SNOMEDCT_US_2016_03_01:19242006 SNOMEDCT_US_2016_03_01:196119001 SNOMEDCT_US_2016_03_01:266408001 UMLS_CUI:C0034063 disease_ontology DOID:11396 pulmonary edema DOID:114 A cardiovascular system disease that involves the heart. ICD10CM:I51.9 ICD9CM:429.9 MESH:D006331 NCI:C3079 SNOMEDCT_US_2016_03_01:155263000 SNOMEDCT_US_2016_03_01:194707003 SNOMEDCT_US_2016_03_01:195152001 SNOMEDCT_US_2016_03_01:266275004 SNOMEDCT_US_2016_03_01:266311004 SNOMEDCT_US_2016_03_01:56265001 UMLS_CUI:C0018799 disease_ontology DOID:114 heart disease DOID:11400 ICD10CM:N10-N16 ICD10CM:N12 ICD10CM:N16 ICD9CM:590.80 MESH:D011704 NCI:C34965 SNOMEDCT_US_2016_03_01:197779009 SNOMEDCT_US_2016_03_01:197784003 SNOMEDCT_US_2016_03_01:45816000 UMLS_CUI:C0034186 disease_ontology DOID:11400 pyelonephritis DOID:1142 ICD10CM:H50.15 ICD9CM:378.15 MESH:D005099 SNOMEDCT_US_2016_03_01:194093000 SNOMEDCT_US_2016_03_01:37214009 UMLS_CUI:C0152207 disease_ontology DOID:1142 alternating exotropia DOID:1143 ICD10CM:H50.1 ICD10CM:H50.10 ICD9CM:378.1 ICD9CM:378.10 MESH:D005099 NCI:C34601 SNOMEDCT_US_2016_03_01:155194007 SNOMEDCT_US_2016_03_01:194086004 SNOMEDCT_US_2016_03_01:194098009 SNOMEDCT_US_2016_03_01:399054005 SNOMEDCT_US_2016_03_01:399252000 SNOMEDCT_US_2016_03_01:75400001 UMLS_CUI:C0015310 Divergent Strabismus Divergent concomitant strabismus disease_ontology DOID:1143 exotropia DOID:11465 ICD9CM:337.1 UMLS_CUI:C0154691 autonomic nervous system disorder disease_ontology DOID:11465 autonomic nervous system disease DOID:11476 A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength. EFO:0003882 ICD10CM:M81.0 ICD9CM:733.0 ICD9CM:733.00 MESH:D010024 MESH:D015663 NCI:C3298 OMIM:166710 SNOMEDCT_US_2016_03_01:156825006 SNOMEDCT_US_2016_03_01:203428004 SNOMEDCT_US_2016_03_01:203440004 SNOMEDCT_US_2016_03_01:64859006 UMLS_CUI:C0029456 disease_ontology DOID:11476 Xref MGI. osteoporosis DOID:1148 DOID:14779 ICD10CM:Q69 ICD10CM:Q69.9 ICD9CM:755.0 ICD9CM:755.00 MESH:C562429 MESH:D017689 NCI:C87110 OMIM:174200 OMIM:174500 OMIM:174700 OMIM:603596 SNOMEDCT_US_2016_03_01:156988007 SNOMEDCT_US_2016_03_01:205119005 SNOMEDCT_US_2016_03_01:205120004 SNOMEDCT_US_2016_03_01:205136002 SNOMEDCT_US_2016_03_01:367506006 SNOMEDCT_US_2016_03_01:403562000 SNOMEDCT_US_2016_03_01:74537000 UMLS_CUI:C0152427 UMLS_CUI:C0220697 postaxial polydactyly disease_ontology Supernumerary digit DOID:1148 polydactyly DOID:11482 A pericardial effusion that results from blood in the pericardial sac. ICD9CM:423.0 MESH:D010490 NCI:C111644 SNOMEDCT_US_2016_03_01:155339006 SNOMEDCT_US_2016_03_01:23412002 UMLS_CUI:C0019064 Haemopericardium disease_ontology DOID:11482 hemopericardium DOID:11486 ICD10CM:G90.2 MESH:D006732 NCI:C28155 SNOMEDCT_US_2016_03_01:12731000 SNOMEDCT_US_2016_03_01:192915005 SNOMEDCT_US_2016_03_01:192922002 SNOMEDCT_US_2016_03_01:271730003 UMLS_CUI:C0019937 Bernard Horner syndrome Horner syndrome cervical sympathetic paralysis disease_ontology DOID:11486 Horner's syndrome DOID:11502 DOID:11737 DOID:13947 ICD10CM:Q23.3 ICD9CM:396.3 ICD9CM:746.6 MESH:D008944 NCI:C50852 NCI:C50888 SNOMEDCT_US_2016_03_01:194736003 SNOMEDCT_US_2016_03_01:194977007 SNOMEDCT_US_2016_03_01:233857005 SNOMEDCT_US_2016_03_01:29928006 SNOMEDCT_US_2016_03_01:48724000 UMLS_CUI:C0026266 UMLS_CUI:C0158619 UMLS_CUI:C0264774 Congenital insufficiency of mitral valve (disorder) Mitral valve incompetence congenital mitral insufficiency congenital mitral regurgitation mitral regurgitation disease_ontology DOID:11502 mitral valve insufficiency DOID:11503 MESH:D003929 NCI:C27068 SNOMEDCT_US_2016_03_01:50620007 UMLS_CUI:C0271686 Diabetic autonomic neuropathy (disorder) disease_ontology DOID:11503 diabetic autonomic neuropathy DOID:11504 CSP:2042-2001 CSP:2049-9000 NCI:C27033 SNOMEDCT_US_2016_03_01:277879009 UMLS_CUI:C0259749 disease_ontology DOID:11504 autonomic neuropathy DOID:11506 A otitis media which involves inflammation of the middle ear with infected effusion containing pus. ICD10CM:H66 ICD10CM:H66.4 ICD10CM:H66.40 ICD9CM:382 ICD9CM:382.4 MESH:D010035 SNOMEDCT_US_2016_03_01:155229002 SNOMEDCT_US_2016_03_01:194258000 SNOMEDCT_US_2016_03_01:194280002 SNOMEDCT_US_2016_03_01:194285007 SNOMEDCT_US_2016_03_01:267758003 SNOMEDCT_US_2016_03_01:38394007 SNOMEDCT_US_2016_03_01:39288006 UMLS_CUI:C0029888 Otitis media with effusion - purulent Purulent otitis media disease_ontology DOID:11506 suppurative otitis media DOID:11512 ICD10CM:I82.0 MESH:D006502 SNOMEDCT_US_2016_03_01:195436007 SNOMEDCT_US_2016_03_01:38739001 UMLS_CUI:C0019154 hepatic vein thrombosis disease_ontology DOID:11512 Budd-Chiari syndrome DOID:11516 A heart disease that is caused by high blood pressure. ICD10CM:I11 ICD10CM:I11.9 ICD9CM:402 ICD9CM:402.9 SNOMEDCT_US_2016_03_01:155297007 SNOMEDCT_US_2016_03_01:194769003 SNOMEDCT_US_2016_03_01:194772005 SNOMEDCT_US_2016_03_01:64715009 UMLS_CUI:C0152105 disease_ontology DOID:11516 hypertensive heart disease DOID:11527 ICD10CM:J38.6 ICD9CM:478.74 MESH:D007829 NCI:C79608 SNOMEDCT_US_2016_03_01:195864007 SNOMEDCT_US_2016_03_01:75547007 UMLS_CUI:C0023075 Stenosis of larynx disease_ontology DOID:11527 laryngostenosis DOID:11541 ICD10CM:H18.83 ICD9CM:371.42 SNOMEDCT_US_2016_03_01:155157003 SNOMEDCT_US_2016_03_01:2055003 SNOMEDCT_US_2016_03_01:267732003 UMLS_CUI:C0155119 recurrent erosion of cornea recurrent erosion syndrome disease_ontology DOID:11541 recurrent corneal erosion DOID:11555 A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision. EFO:0003946 ICD10CM:H18.51 MESH:D005642 NCI:C84721 OMIM:136800 OMIM:610158 OMIM:613267 OMIM:613268 OMIM:613269 OMIM:613270 OMIM:613271 OMIM:615523 ORDO:98974 SNOMEDCT_US_2016_03_01:16949007 SNOMEDCT_US_2016_03_01:193839007 SNOMEDCT_US_2016_03_01:393581005 UMLS_CUI:C0016781 FCED Fuchs' corneal dystrophy Fuchs' endothelial corneal dystrophy disease_ontology DOID:11555 Xref MGI. Fuchs' endothelial dystrophy DOID:1156 An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint. DOID:11303 DOID:1155 DOID:12090 DOID:12102 DOID:12945 DOID:13298 DOID:13299 DOID:13301 DOID:13302 DOID:13303 DOID:13304 DOID:14143 DOID:14220 DOID:14513 DOID:1834 DOID:1945 DOID:2486 HP:0000934 ICD9CM:712.1 MESH:D002805 NCI:C34955 OMIM:118600 OMIM:118610 OMIM:600668 ORDO:1416 SNOMEDCT_US_2016_03_01:156881000 SNOMEDCT_US_2016_03_01:201624004 SNOMEDCT_US_2016_03_01:201625003 SNOMEDCT_US_2016_03_01:201636005 SNOMEDCT_US_2016_03_01:239834007 SNOMEDCT_US_2016_03_01:268142006 SNOMEDCT_US_2016_03_01:60782007 UMLS_CUI:C0033802 UMLS_CUI:C0157852 calcium pyrophosphate deposition disease pseudogout disease_ontology DOID:1156 Xref MGI. chondrocalcinosis DOID:1159 ICD9CM:536.8 UMLS_CUI:C0013396 disease_ontology DOID:1159 functional gastric disease DOID:11612 A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight. EFO:0000660 ICD10CM:E28.2 ICD9CM:256.4 MESH:D011085 NCI:C26862 OMIM:184700 SNOMEDCT_US_2016_03_01:154714009 SNOMEDCT_US_2016_03_01:190549002 SNOMEDCT_US_2016_03_01:237055002 SNOMEDCT_US_2016_03_01:237792009 SNOMEDCT_US_2016_03_01:271199009 SNOMEDCT_US_2016_03_01:69878008 UMLS_CUI:C0032460 Multicystic ovaries PCOS Polycystic Ovarian disease Polycystic ovaries Polycystic ovaries (disorder) Polycystic ovary syndrome Stein-Leventhal synd. Stein-Leventhal syndrome polycystic ovary disease_ontology DOID:11612 OMIM mapping confirmed by DO. [SN]. polycystic ovary syndrome DOID:11613 MESH:D017588 SNOMEDCT_US_2016_03_01:237793004 UMLS_CUI:C0206081 hyperandrogenization syndrome disease_ontology DOID:11613 hyperandrogenism DOID:11633 MESH:D018382 NCI:C85191 OMIM:188570 OMIM:274300 SNOMEDCT_US_2016_03_01:111567006 SNOMEDCT_US_2016_03_01:237559000 SNOMEDCT_US_2016_03_01:237560005 SNOMEDCT_US_2016_03_01:50375007 UMLS_CUI:C2940786 Generalized thyroid hormone resistance (disorder) Refetoff syndrome (disorder) Thyroid hormone resistance syndrome (disorder) Thyroid hormone responsiveness defect (disorder) thyroid hormone resistance disease_ontology DOID:11633 OMIM mapping confirmed by DO. [LS]. thyroid hormone resistance syndrome DOID:11634 ICD10CM:E03.9 MESH:D009230 NCI:C34834 OMIM:255900 SNOMEDCT_US_2016_03_01:154660000 SNOMEDCT_US_2016_03_01:190274003 SNOMEDCT_US_2016_03_01:267465007 SNOMEDCT_US_2016_03_01:43153006 UMLS_CUI:C0027145 disease_ontology DOID:11634 OMIM mapping confirmed by DO. [SN]. myxedema DOID:11665 ICD10CM:Q91.7 ICD9CM:758.1 MESH:C536305 NCI:C101223 SNOMEDCT_US_2016_03_01:156995003 SNOMEDCT_US_2016_03_01:157021007 SNOMEDCT_US_2016_03_01:205622008 SNOMEDCT_US_2016_03_01:21111006 SNOMEDCT_US_2016_03_01:254267009 SNOMEDCT_US_2016_03_01:268344000 SNOMEDCT_US_2016_03_01:268357008 UMLS_CUI:C0152095 D1 Trisomy trisomy 13 disease_ontology Patau's syndrome DOID:11665 OMIM mapping confirmed by DO. [LS]. Patau syndrome DOID:11678 A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy. ICD10CM:B73 ICD9CM:125.3 MESH:D009855 NCI:C34861 SNOMEDCT_US_2016_03_01:38539003 UMLS_CUI:C0029001 Infection by Onchocerca volvulus (disorder) Onchocerca volvulus infection volvulosis disease_ontology DOID:11678 onchocerciasis DOID:1168 DOID:3147 ICD10CM:E78.5 MESH:D006949 MESH:D006951 NCI:C34707 NCI:C34709 SNOMEDCT_US_2016_03_01:154739000 SNOMEDCT_US_2016_03_01:154743001 SNOMEDCT_US_2016_03_01:190782002 SNOMEDCT_US_2016_03_01:267499005 SNOMEDCT_US_2016_03_01:3744001 SNOMEDCT_US_2016_03_01:55822004 UMLS_CUI:C0020473 UMLS_CUI:C0020476 familial hyperlipoproteinemia hyperlipemia disease_ontology hyperlipidaemia DOID:1168 familial hyperlipidemia DOID:11695 A vein disease that is characterized by a blood clot that forms within the hepatic portal vein. ICD10CM:I81 ICD9CM:452 NCI:C78565 SNOMEDCT_US_2016_03_01:155455003 SNOMEDCT_US_2016_03_01:17920008 UMLS_CUI:C0155773 disease_ontology DOID:11695 portal vein thrombosis DOID:117 A cardiovascular cancer located_in the heart. DOID:9918 ICD10CM:C38.0 ICD9CM:164.1 MESH:D006338 NCI:C3081 NCI:C3548 SNOMEDCT_US_2016_03_01:126730001 SNOMEDCT_US_2016_03_01:154555009 SNOMEDCT_US_2016_03_01:187886009 SNOMEDCT_US_2016_03_01:269615000 SNOMEDCT_US_2016_03_01:363435002 SNOMEDCT_US_2016_03_01:387842002 SNOMEDCT_US_2016_03_01:93825008 UMLS_CUI:C0018809 UMLS_CUI:C0153500 Cardiac tumor Tumour of heart malignant Cardiac tumor malignant neoplasm of heart disease_ontology DOID:117 heart cancer DOID:11705 ICD9CM:588.8 ICD9CM:588.89 UMLS_CUI:C0029791 disease_ontology DOID:11705 impaired renal function disease DOID:11714 EFO:0004593 ICD10CM:O24.4 MESH:D016640 NCI:C34942 SNOMEDCT_US_2016_03_01:11687002 SNOMEDCT_US_2016_03_01:199232003 SNOMEDCT_US_2016_03_01:237629002 SNOMEDCT_US_2016_03_01:359964007 SNOMEDCT_US_2016_03_01:393568003 UMLS_CUI:C0085207 GDM Gestational diabetes mellitus Maternal gestational diabetes mellitus disease_ontology DOID:11714 gestational diabetes DOID:11721 ICD10CM:E74.09 MESH:D006014 NCI:C118437 OMIM:232800 SNOMEDCT_US_2016_03_01:234406005 SNOMEDCT_US_2016_03_01:89597008 UMLS_CUI:C0017926 Glycogen storage disease, type VII (disorder) Muscle phosphofructokinase deficiency (disorder) glycogen storage disease type VII phosphofructokinase myopathy disease_ontology DOID:11721 OMIM mapping confirmed by DO. [SN]. glycogen storage disease VII DOID:11722 A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_physical_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region. ICD10CM:G71.11 ICD9CM:359.21 MESH:D009223 NCI:C84914 OMIM:160900 SNOMEDCT_US_2016_03_01:155096007 SNOMEDCT_US_2016_03_01:267713009 SNOMEDCT_US_2016_03_01:77956009 UMLS_CUI:C0027126 Dystrophia myotonica Steinert disease congenital myotonic dystrophy myotonic dystrophy of Steinert disease_ontology DOID:11722 OMIM mapping confirmed by DO. [SN]. myotonic dystrophy type 1 DOID:11723 A muscular dystrophy that has_material_basis_in X-linked disease that has material basis in mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy. MESH:D020388 NCI:C75482 OMIM:310200 SNOMEDCT_US_2016_03_01:129619006 SNOMEDCT_US_2016_03_01:155095006 SNOMEDCT_US_2016_03_01:267712004 SNOMEDCT_US_2016_03_01:387732009 SNOMEDCT_US_2016_03_01:76670001 UMLS_CUI:C0013264 Muscular dystrophy, Duchenne disease_ontology DOID:11723 OMIM mapping confirmed by DO. [SN]. Duchenne muscular dystrophy DOID:11724 A muscular dystrophy that is characterized by weakening of the muscles of the hip and shoulders which comprise the limb girdle muscles. ICD10CM:G71.0 MESH:D049288 NCI:C84828 ORDO:263 SNOMEDCT_US_2016_03_01:56096001 SNOMEDCT_US_2016_03_01:93153005 UMLS_CUI:C0686353 Erb's muscular dystrophy Leyden-Mbius muscular dystrophy limb girdle muscular dystrophy disease_ontology DOID:11724 Xref MGI. OMIM mapping confirmed by DO. [SN]. limb-girdle muscular dystrophy DOID:11726 A muscular dystrophy that chiefly affects muscles used for movement (skeletal) and heart (cardiac) muscle. MESH:D020389 NCI:C84685 OMIM:181350 OMIM:300696 OMIM:310300 OMIM:612998 OMIM:612999 OMIM:614302 ORDO:261 ORDO:98853 ORDO:98855 ORDO:98863 SNOMEDCT_US_2016_03_01:111508004 SNOMEDCT_US_2016_03_01:129620000 SNOMEDCT_US_2016_03_01:193233004 UMLS_CUI:C0410189 EDMD disease_ontology DOID:11726 Xref MGI. OMIM mapping confirmed by DO. [SN]. Emery-Dreifuss muscular dystrophy DOID:11729 A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. DOID:12233 ICD10CM:A69.2 ICD10CM:A69.20 ICD9CM:088.81 MESH:D008193 MESH:D020852 NCI:C45161 SNOMEDCT_US_2016_03_01:154376000 SNOMEDCT_US_2016_03_01:23502006 SNOMEDCT_US_2016_03_01:240672009 SNOMEDCT_US_2016_03_01:48982009 UMLS_CUI:C0024198 UMLS_CUI:C0752235 Bannwarth syndrome (disorder) Bannworth's syndrome Lyme borreliosis Neurological Lyme disease lyme neuroborreliosis neuroborreliosis disease_ontology DOID:11729 Lyme disease DOID:1176 A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. DOID:1175 DOID:12322 MESH:D001982 SNOMEDCT_US_2016_03_01:41427001 UMLS_CUI:C0006261 Bronchospasm disease_ontology DOID:1176 bronchial disease DOID:11772 ICD10CM:H44.53 ICD9CM:360.44 SNOMEDCT_US_2016_03_01:1361009 SNOMEDCT_US_2016_03_01:193288000 UMLS_CUI:C0152458 Leucocoria disease_ontology DOID:11772 leukocoria DOID:11782 A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has_symptom blurred vision. CSP:1116-1831 EFO:0004222 HP:0000483 ICD10CM:H52.2 ICD10CM:H52.20 ICD9CM:367.2 ICD9CM:367.20 MESH:D001251 OMIM:603047 SNOMEDCT_US_2016_03_01:155134009 SNOMEDCT_US_2016_03_01:193626006 SNOMEDCT_US_2016_03_01:193627002 SNOMEDCT_US_2016_03_01:82649003 UMLS_CUI:C0004106 disease_ontology DOID:11782 OMIM mapping confirmed by DO. [SN]. astigmatism DOID:118 A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity. MESH:D010490 NCI:C3319 SNOMEDCT_US_2016_03_01:373945007 SNOMEDCT_US_2016_03_01:70370001 UMLS_CUI:C0031039 disease_ontology DOID:118 pericardial effusion DOID:11801 ICD10CM:E46 ICD9CM:263.9 MESH:D011502 NCI:C34952 SNOMEDCT_US_2016_03_01:190608007 SNOMEDCT_US_2016_03_01:238107002 SNOMEDCT_US_2016_03_01:267411007 SNOMEDCT_US_2016_03_01:72608005 UMLS_CUI:C0033677 disease_ontology DOID:11801 protein-energy malnutrition DOID:11816 ICD10CM:H43.81 ICD9CM:379.21 SNOMEDCT_US_2016_03_01:247090008 SNOMEDCT_US_2016_03_01:60189009 UMLS_CUI:C0155366 Vitreous degeneration disease_ontology DOID:11816 vitreous syneresis DOID:11819 A urinary system cancer that is located_in the ureter. ICD10CM:C66 ICD9CM:189.2 MESH:D014516 NCI:C7543 OMIM:191600 SNOMEDCT_US_2016_03_01:154543003 SNOMEDCT_US_2016_03_01:363458004 SNOMEDCT_US_2016_03_01:94121005 UMLS_CUI:C0153619 malignant tumour of ureter malignant ureteral tumor disease_ontology DOID:11819 OMIM mapping confirmed by DO. [SN]. ureter cancer DOID:11829 EFO:0004207 ICD10CM:H44.2 ICD9CM:360.21 MESH:D047728 SNOMEDCT_US_2016_03_01:193276002 SNOMEDCT_US_2016_03_01:193278001 SNOMEDCT_US_2016_03_01:193625005 SNOMEDCT_US_2016_03_01:32022003 UMLS_CUI:C0154778 degenerative progressive high myopia pathological myopia progressive high (degenerative) myopia progressive high myopia disease_ontology DOID:11829 degenerative myopia DOID:11830 A refractive error characterized by the inability to see farther objects clearly. EFO:0003927 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613959 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 SNOMEDCT_US_2016_03_01:155133003 SNOMEDCT_US_2016_03_01:57190000 UMLS_CUI:C0027092 near vision near-sightedness short-sightedness disease_ontology DOID:11830 Xref MGI. myopia DOID:1184 ICD10CM:N04 ICD9CM:581 MESH:D009404 NCI:C34845 OMIM:256300 OMIM:256370 OMIM:600995 OMIM:610725 OMIM:614196 OMIM:614199 OMIM:615008 OMIM:615244 OMIM:615573 OMIM:615861 SNOMEDCT_US_2016_03_01:155851004 SNOMEDCT_US_2016_03_01:197611005 SNOMEDCT_US_2016_03_01:52254009 UMLS_CUI:C0027726 finnish congenital nephrosis disease_ontology DOID:1184 Xref MGI. nephrotic syndrome DOID:11847 ICD10CM:I21 ICD10CM:I22 MESH:D003328 SNOMEDCT_US_2016_03_01:155304006 SNOMEDCT_US_2016_03_01:194796000 SNOMEDCT_US_2016_03_01:266288001 SNOMEDCT_US_2016_03_01:398274000 SNOMEDCT_US_2016_03_01:66514008 UMLS_CUI:C0010072 Coronary artery thrombosis (disorder) disease_ontology DOID:11847 coronary thrombosis DOID:11875 ICD10CM:K12.1 MESH:D013282 SNOMEDCT_US_2016_03_01:196576008 SNOMEDCT_US_2016_03_01:69254008 UMLS_CUI:C0038364 Denture sore mouth disease_ontology DOID:11875 denture stomatitis DOID:1188 A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve. ICD10CM:G58.9 MESH:D020422 SNOMEDCT_US_2016_03_01:128189008 SNOMEDCT_US_2016_03_01:304595001 UMLS_CUI:C0494491 disease_ontology DOID:1188 mononeuropathy DOID:119 A female reproductive system cancer that is located_in the vagina. DOID:1902 ICD10CM:C52 ICD9CM:184.0 MESH:D014625 NCI:C3437 NCI:C7410 SNOMEDCT_US_2016_03_01:126921000 SNOMEDCT_US_2016_03_01:154534007 SNOMEDCT_US_2016_03_01:188210000 SNOMEDCT_US_2016_03_01:363445000 UMLS_CUI:C0042237 UMLS_CUI:C0042258 malignant neoplasm of vagina malignant tumor of vagina (disorder) malignant vaginal tumor neoplasm of vagina (disorder) vagina neoplasm vaginal tumor disease_ontology DOID:119 vaginal cancer DOID:11914 ICD10CM:K31.84 ICD9CM:536.3 MESH:D018589 NCI:C80512 SNOMEDCT_US_2016_03_01:196753007 SNOMEDCT_US_2016_03_01:235675006 SNOMEDCT_US_2016_03_01:77164002 UMLS_CUI:C0152020 Gastroparalysis Gastroparesis syndrome gastric atonia disease_ontology DOID:11914 gastroparesis DOID:1192 A nervous system cancer that is located_in the peripheral nervous system. DOID:3194 MESH:D010524 MESH:D018317 NCI:C3321 NCI:C4972 SNOMEDCT_US_2016_03_01:115242003 SNOMEDCT_US_2016_03_01:126980002 SNOMEDCT_US_2016_03_01:134214003 SNOMEDCT_US_2016_03_01:189946005 SNOMEDCT_US_2016_03_01:189953001 UMLS_CUI:C0031118 UMLS_CUI:C0206727 neoplasm of peripheral nerve (disorder) nerve sheath neoplasm nerve sheath tumors tumor of PNS disease_ontology DOID:1192 peripheral nervous system neoplasm DOID:11934 An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx. MESH:D006258 NCI:C3077 SNOMEDCT_US_2016_03_01:255055008 UMLS_CUI:C0018671 head and neck neoplasm head and neck tumours head/neck neoplasm tumor of head and neck (disorder) disease_ontology DOID:11934 head and neck cancer DOID:11963 DOID:11962 ICD10CM:K20 ICD10CM:K20.9 ICD9CM:530.1 ICD9CM:530.10 MESH:D004941 NCI:C9224 SNOMEDCT_US_2016_03_01:155673008 SNOMEDCT_US_2016_03_01:16761005 SNOMEDCT_US_2016_03_01:196605000 SNOMEDCT_US_2016_03_01:266498005 UMLS_CUI:C0014868 acute esophagitis disease_ontology DOID:11963 esophagitis DOID:11971 A dysostosis that results_in abnormal fusing of adjacent bones. MESH:D013580 UMLS_CUI:C0039093 disease_ontology DOID:11971 synostosis DOID:11983 ICD10CM:Q87.1 ICD9CM:759.81 MESH:D011218 NCI:C75463 OMIM:176270 SNOMEDCT_US_2016_03_01:205794007 SNOMEDCT_US_2016_03_01:89392001 UMLS_CUI:C0032897 Prader Willi syndrome disease_ontology DOID:11983 OMIM mapping confirmed by DO. [SN]. Prader-Willi syndrome DOID:11984 An intrinsic cardiomyopathy that has_material_basis_in autosomal dominant inheritance and that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause. DOID:11986 ICD10CM:I42.1 ICD9CM:425.1 ICD9CM:425.11 KEGG:05410 MESH:D002312 MESH:D024741 NCI:C34449 NCI:C84773 OMIM:PS192600 ORDO:155 SNOMEDCT_US_2016_03_01:15471000 SNOMEDCT_US_2016_03_01:155351008 SNOMEDCT_US_2016_03_01:233873004 SNOMEDCT_US_2016_03_01:266301006 SNOMEDCT_US_2016_03_01:389998005 SNOMEDCT_US_2016_03_01:389999002 SNOMEDCT_US_2016_03_01:45227007 SNOMEDCT_US_2016_03_01:83978005 UMLS_CUI:C0007194 UMLS_CUI:C0949658 familial hypertrophic cardiomyopathy hypertrophic obstructive cardiomyopathy disease_ontology DOID:11984 Xref MGI. OMIM mapping confirmed by DO. [SN]. hypertrophic cardiomyopathy DOID:11996 ICD10CM:N44.0 ICD10CM:N44.00 ICD10CM:N44.02 ICD9CM:608.2 ICD9CM:608.20 MESH:D013086 NCI:C26885 OMIM:187400 SNOMEDCT_US_2016_03_01:155937003 SNOMEDCT_US_2016_03_01:198045001 SNOMEDCT_US_2016_03_01:198046000 SNOMEDCT_US_2016_03_01:198048004 SNOMEDCT_US_2016_03_01:49198006 SNOMEDCT_US_2016_03_01:81996005 UMLS_CUI:C0037856 Torsion of testicle Torsion of testis testicular Torsion disease_ontology DOID:11996 spermatic cord torsion DOID:120 A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva. DOID:1244 DOID:1281 ICD10CM:C57 ICD9CM:184 MESH:D005833 NCI:C3053 NCI:C4913 SNOMEDCT_US_2016_03_01:126907002 SNOMEDCT_US_2016_03_01:188207007 UMLS_CUI:C0017416 UMLS_CUI:C0153585 UMLS_CUI:C0699889 female reproductive cancer malignant Gynecologic tumor malignant neoplasm of female genital organ disease_ontology DOID:120 female reproductive organ cancer DOID:12010 ICD10CM:H47.01 ICD9CM:377.41 MESH:D018917 SNOMEDCT_US_2016_03_01:14357004 UMLS_CUI:C0155305 Ischemic optic neuropathy disease_ontology DOID:12010 anterior ischemic optic neuropathy DOID:12028 An adrenal admenoma characterized by over production of aldosterone. ICD10CM:E26.0 ICD10CM:E26.01 ICD9CM:255.12 MESH:D006929 NCI:C34510 SNOMEDCT_US_2016_03_01:13536004 SNOMEDCT_US_2016_03_01:154709005 SNOMEDCT_US_2016_03_01:190506003 SNOMEDCT_US_2016_03_01:190507007 SNOMEDCT_US_2016_03_01:258117004 SNOMEDCT_US_2016_03_01:267484005 UMLS_CUI:C1384514 Conn syndrome primary aldosteronism primary hyperaldosteronism disease_ontology DOID:12028 Conn's syndrome DOID:1203 ICD9CM:292.8 ICD9CM:292.89 UMLS_CUI:C0154325 disease_ontology DOID:1203 drug-induced mental disorder DOID:12030 ICD10CM:H44.11 ICD9CM:360.12 MESH:D015864 NCI:C84989 SNOMEDCT_US_2016_03_01:75614007 UMLS_CUI:C0030343 Diffuse uveitis disease_ontology DOID:12030 panuveitis DOID:1205 An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods. ICD10CM:T78.40 MESH:D006967 NCI:C3114 SNOMEDCT_US_2016_03_01:106190000 SNOMEDCT_US_2016_03_01:127072000 SNOMEDCT_US_2016_03_01:157754004 SNOMEDCT_US_2016_03_01:157758001 SNOMEDCT_US_2016_03_01:212998004 SNOMEDCT_US_2016_03_01:212999007 SNOMEDCT_US_2016_03_01:21957007 SNOMEDCT_US_2016_03_01:257550005 SNOMEDCT_US_2016_03_01:269284003 SNOMEDCT_US_2016_03_01:269432007 SNOMEDCT_US_2016_03_01:274211000 SNOMEDCT_US_2016_03_01:282092005 SNOMEDCT_US_2016_03_01:418168000 SNOMEDCT_US_2016_03_01:418634005 SNOMEDCT_US_2016_03_01:418925002 SNOMEDCT_US_2016_03_01:421668005 SNOMEDCT_US_2016_03_01:421961002 SNOMEDCT_US_2016_03_01:91232002 UMLS_CUI:C0020517 allergic disease allergy hypersensitivity hypersensitivity reaction type I disease disease_ontology DOID:1205 allergic hypersensitivity disease DOID:12053 An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii. ICD10CM:B45 ICD10CM:B45.9 ICD9CM:117.5 MESH:D003453 NCI:C2967 SNOMEDCT_US_2016_03_01:187090005 SNOMEDCT_US_2016_03_01:187097008 SNOMEDCT_US_2016_03_01:187494009 SNOMEDCT_US_2016_03_01:20850004 SNOMEDCT_US_2016_03_01:42386007 UMLS_CUI:C0010414 Busse-Buschke's disease European cryptococcosis cryptococcal infection torula torulosis disease_ontology cryptococcus neoformans infection DOID:12053 cryptococcosis DOID:1206 A pervasive developmental disease that is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability. ICD10CM:F84.2 MESH:D015518 NCI:C75488 OMIM:312750 OMIM:613454 SNOMEDCT_US_2016_03_01:192583003 SNOMEDCT_US_2016_03_01:68618008 UMLS_CUI:C0035372 Rett's disorder cerebroatrophic hyperammonemia disease_ontology DOID:1206 OMIM mapping confirmed by DO. [SN]. Rett syndrome DOID:12072 ICD9CM:537.81 SNOMEDCT_US_2016_03_01:335002 UMLS_CUI:C0152163 disease_ontology DOID:12072 pylorospasm DOID:12098 ICD10CM:G50.0 ICD9CM:350.1 MESH:D014277 OMIM:190400 SNOMEDCT_US_2016_03_01:155066002 SNOMEDCT_US_2016_03_01:193090007 SNOMEDCT_US_2016_03_01:31681005 SNOMEDCT_US_2016_03_01:322769008 UMLS_CUI:C0040997 Trifacial neuralgia Trigeminal neuralgia Trigeminal neuralgia (disorder) Trigeminal neuralgia NOS (disorder) Trigeminal neuralgia [no drugs here] (disorder) trifocal neuralgia disease_ontology DOID:12098 OMIM mapping confirmed by DO. [LS]. trigeminal neuralgia DOID:121 MESH:D014623 NCI:C26910 SNOMEDCT_US_2016_03_01:156015000 SNOMEDCT_US_2016_03_01:156018003 SNOMEDCT_US_2016_03_01:25658005 SNOMEDCT_US_2016_03_01:266665005 SNOMEDCT_US_2016_03_01:286989007 UMLS_CUI:C0042251 disease_ontology DOID:121 vaginal disease DOID:12120 A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange. ICD10CM:J84.01 ICD9CM:516.0 MESH:D011649 NCI:C85037 OMIM:265120 OMIM:300770 OMIM:610913 OMIM:610921 OMIM:614370 ORDO:264675 SNOMEDCT_US_2016_03_01:10501004 UMLS_CUI:C0034050 disease_ontology DOID:12120 Xref MGI. pulmonary alveolar proteinosis DOID:12129 An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem. ICD10CM:F50.2 MESH:D002032 NCI:C97162 OMIM:607499 OMIM:610269 SNOMEDCT_US_2016_03_01:192013000 SNOMEDCT_US_2016_03_01:192447005 SNOMEDCT_US_2016_03_01:206939001 SNOMEDCT_US_2016_03_01:78004001 UMLS_CUI:C0006370 hyperorexia nervosa disease_ontology DOID:12129 Xref MGI. bulimia nervosa DOID:12132 An autoimmune disease that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels. ICD10CM:M31.3 ICD10CM:M31.30 ICD9CM:446.4 MESH:D014890 NCI:C3444 OMIM:608710 SNOMEDCT_US_2016_03_01:155445002 SNOMEDCT_US_2016_03_01:195353004 SNOMEDCT_US_2016_03_01:23782005 SNOMEDCT_US_2016_03_01:239934006 SNOMEDCT_US_2016_03_01:266323005 SNOMEDCT_US_2016_03_01:390001000 UMLS_CUI:C3495801 Granulomatosis - Wegener's Necrotizing respiratory granulomatosis Wegener granulomatosis Wegener's syndrome (disorder) disease_ontology DOID:12132 Wegener's granulomatosis DOID:12139 A mood disorder that involves the presence of a low mood almost daily over a span of at least two years. ICD10CM:F34.1 ICD9CM:300.4 MESH:D019263 NCI:C34562 SNOMEDCT_US_2016_03_01:192384008 SNOMEDCT_US_2016_03_01:78667006 UMLS_CUI:C0013415 dysthymia disease_ontology DOID:12139 dysthymic disorder DOID:1214 ICD9CM:385.09 SNOMEDCT_US_2016_03_01:111540000 UMLS_CUI:C0155477 disease_ontology DOID:1214 tympanosclerosis DOID:12140 A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis. DOID:0050016 DOID:0050019 DOID:0050020 ICD9CM:086.2 KEGG:05142 SNOMEDCT_US_2016_03_01:186817003 SNOMEDCT_US_2016_03_01:54570006 SNOMEDCT_US_2016_03_01:94371000119107 UMLS_CUI:C0007932 Chagas' disease chagas' disease with digestive system involvement chagas' disease with nervous system involvement chagas' disease with other organ involvement disease_ontology American trypanosomiasis DOID:12140 Chagas disease DOID:12143 ICD9CM:596.54 MESH:D001750 NCI:C79696 SNOMEDCT_US_2016_03_01:155032006 SNOMEDCT_US_2016_03_01:192972000 SNOMEDCT_US_2016_03_01:197883004 SNOMEDCT_US_2016_03_01:23201000 SNOMEDCT_US_2016_03_01:397732007 SNOMEDCT_US_2016_03_01:398064005 UMLS_CUI:C0005697 Neuropathic bladder neurogenic dysfunction of the urinary bladder neurogenic urinary bladder disorder disease_ontology DOID:12143 neurogenic bladder DOID:12144 ICD9CM:596.52 SNOMEDCT_US_2016_03_01:9009001 UMLS_CUI:C0489967 Low bladder compliance hyperactivity of bladder hypertonic bladder hypertonicity of bladder disease_ontology DOID:12144 low compliance bladder DOID:12161 ICD10CM:H35.4 ICD10CM:H35.40 ICD9CM:362.6 ICD9CM:362.60 NCI:C34919 SNOMEDCT_US_2016_03_01:193393004 SNOMEDCT_US_2016_03_01:193394005 SNOMEDCT_US_2016_03_01:193398008 SNOMEDCT_US_2016_03_01:405721006 SNOMEDCT_US_2016_03_01:61536007 SNOMEDCT_US_2016_03_01:95704002 UMLS_CUI:C1320640 peripheral degeneration of retina disease_ontology DOID:12161 peripheral retinal degeneration DOID:12171 MESH:D020425 SNOMEDCT_US_2016_03_01:16644004 UMLS_CUI:C0748226 Radial neuropathy (disorder) disease_ontology DOID:12171 radial neuropathy DOID:12176 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland. ICD10CM:E04.9 ICD9CM:240.9 MESH:D006042 NCI:C26785 SNOMEDCT_US_2016_03_01:190232008 SNOMEDCT_US_2016_03_01:190235005 SNOMEDCT_US_2016_03_01:237568003 SNOMEDCT_US_2016_03_01:267370001 SNOMEDCT_US_2016_03_01:3716002 UMLS_CUI:C0018021 goitre disease_ontology DOID:12176 goiter DOID:12177 A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM). ICD10CM:D83 ICD10CM:D83.9 ICD9CM:279.06 MESH:D017074 OMIM:240500 OMIM:607594 OMIM:613493 OMIM:613494 OMIM:613495 OMIM:613496 OMIM:614699 OMIM:614700 OMIM:615577 OMIM:615767 ORDO:1572 SNOMEDCT_US_2016_03_01:191010004 SNOMEDCT_US_2016_03_01:23238000 UMLS_CUI:C0009447 CVID acquired agammaglobulinemia acquired hypogammaglobulinemia common variable agammaglobulinemia sporadic hypogammaglobulinemia disease_ontology DOID:12177 Xref MGI. OMIM mapping confirmed by DO. [SN]. common variable immunodeficiency DOID:12185 An otitis interna characterized by an abnormal bone growth in the middle ear. EFO:0004213 ICD10CM:H80.8 ICD10CM:H80.80 ICD9CM:387.8 OMIM:166800 OMIM:605727 OMIM:608244 OMIM:608484 OMIM:611571 OMIM:611572 OMIM:612096 OMIM:615589 ORDO:2794 SNOMEDCT_US_2016_03_01:194382008 SNOMEDCT_US_2016_03_01:194691004 UMLS_CUI:C0029696 disease_ontology DOID:12185 Xref MGI. otosclerosis DOID:12196 ICD10CM:H16.10 ICD9CM:370.20 SNOMEDCT_US_2016_03_01:193766004 SNOMEDCT_US_2016_03_01:27019000 UMLS_CUI:C0155074 disease_ontology DOID:12196 superficial keratitis DOID:12197 ICD10CM:H16.14 ICD9CM:370.21 SNOMEDCT_US_2016_03_01:193767008 SNOMEDCT_US_2016_03_01:267634006 SNOMEDCT_US_2016_03_01:416069001 SNOMEDCT_US_2016_03_01:42513006 UMLS_CUI:C0259799 Punctate keratitis Thygeson superficial punctate keratitis Thygeson's superficial punctate keratitis disease_ontology DOID:12197 punctate epithelial keratoconjunctivitis DOID:12205 A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding. DOID:0050142 ICD10CM:A90 ICD9CM:061 MESH:D003715 NCI:C34528 SNOMEDCT_US_2016_03_01:154345006 SNOMEDCT_US_2016_03_01:266194002 SNOMEDCT_US_2016_03_01:38362002 UMLS_CUI:C0011311 Dengue Fever breakbone fever classic dengue disease_ontology classical dengue DOID:12205 dengue disease DOID:12223 ICD9CM:727.2 SNOMEDCT_US_2016_03_01:42812006 UMLS_CUI:C0158332 Specific bursitides often of occupational origin Specific bursitis often of occupational origin (disorder) disease_ontology DOID:12223 specific bursitis often of occupational origin DOID:12236 A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts. DOID:1851 EFO:0004267 ICD10CM:K74.3 ICD10CM:K74.5 ICD9CM:571.6 MESH:D008105 NCI:C27167 NCI:C51225 OMIM:109720 OMIM:613007 OMIM:613008 OMIM:614220 OMIM:614221 ORDO:186 SNOMEDCT_US_2016_03_01:155815006 SNOMEDCT_US_2016_03_01:1761006 SNOMEDCT_US_2016_03_01:197311004 SNOMEDCT_US_2016_03_01:266540000 SNOMEDCT_US_2016_03_01:31712002 UMLS_CUI:C0008312 UMLS_CUI:C0023892 biliary liver cirrhosis cholestatic cirrhosis chronic nonsuppurative destructive cholangitis disease_ontology DOID:12236 Xref MGI. OMIM mapping confirmed by DO. [SN]. primary biliary cirrhosis DOID:12241 A thalassemia characterized by the reduced or absent synthesis of the beta globin chains of hemoglobin. ICD10CM:D56.1 ICD9CM:282.44 MESH:D017086 NCI:C34375 OMIM:187550 OMIM:603902 OMIM:613985 ORDO:848 SNOMEDCT_US_2016_03_01:191190000 SNOMEDCT_US_2016_03_01:65959000 UMLS_CUI:C0005283 disease_ontology DOID:12241 Xref MGI. OMIM mapping confirmed by DO. [SN]. beta thalassemia DOID:12252 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland. ICD10CM:E24 ICD10CM:E24.9 ICD9CM:255.0 MESH:D003480 NCI:C2969 SNOMEDCT_US_2016_03_01:154705004 SNOMEDCT_US_2016_03_01:190505004 SNOMEDCT_US_2016_03_01:47270006 UMLS_CUI:C0010481 Cushing syndrome Suprarenogenic syndrome pituitary basophilism disease_ontology DOID:12252 Cushing's syndrome DOID:1227 ICD10CM:D70 ICD10CM:D70.9 ICD9CM:288.0 ICD9CM:288.00 MESH:D009503 SNOMEDCT_US_2016_03_01:142928004 SNOMEDCT_US_2016_03_01:191336001 SNOMEDCT_US_2016_03_01:303011007 SNOMEDCT_US_2016_03_01:72885007 UMLS_CUI:C0027947 disease_ontology DOID:1227 neutropenia DOID:12270 An eye disease characterized by missing pieces of tissue in structures that form the eye, such as the iris, retina, choroid or optic disc. ICD10CM:Q13.0 MESH:D003103 NCI:C98877 OMIM:120200 OMIM:120300 OMIM:216820 ORDO:194 ORDO:98945 SNOMEDCT_US_2016_03_01:92828000 SNOMEDCT_US_2016_03_01:93390002 UMLS_CUI:C0009363 coloboma of eye coloboma of macula congenital ocular coloboma disease_ontology DOID:12270 Xref MGI. OMIM mapping confirmed by DO. [SN]. coloboma DOID:12294 A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection. ICD10CM:F32.8 ICD9CM:296.82 SNOMEDCT_US_2016_03_01:191659001 SNOMEDCT_US_2016_03_01:192371004 SNOMEDCT_US_2016_03_01:277538003 UMLS_CUI:C0154437 Atypical depression disease_ontology DOID:12294 atypical depressive disorder DOID:12305 ICD10CM:Q82.3 MESH:D007184 NCI:C84787 OMIM:308300 SNOMEDCT_US_2016_03_01:205567005 SNOMEDCT_US_2016_03_01:367520004 SNOMEDCT_US_2016_03_01:806001 UMLS_CUI:C0021171 Incontinentia pigmenti (disorder) Incontinentia pigmenti syndrome (disorder) disease_ontology DOID:12305 OMIM mapping confirmed by DO. [SN]. Bloch-Sulzberger syndrome DOID:12306 A hypersensitivity reaction type II disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes. EFO:0004208 ICD10CM:L80 ICD9CM:709.01 MESH:D014820 NCI:C26915 OMIM:193200 SNOMEDCT_US_2016_03_01:156437000 SNOMEDCT_US_2016_03_01:56727007 UMLS_CUI:C0042900 disease_ontology DOID:12306 OMIM mapping confirmed by DO. [LS]. vitiligo DOID:12326 ICD9CM:416.8 SNOMEDCT_US_2016_03_01:194887007 SNOMEDCT_US_2016_03_01:194889005 UMLS_CUI:C0155673 disease_ontology DOID:12326 chronic pulmonary heart disease DOID:12336 ICD10CM:N46 ICD10CM:N46.9 ICD9CM:606 ICD9CM:606.9 MESH:D007248 SNOMEDCT_US_2016_03_01:155924001 SNOMEDCT_US_2016_03_01:198018002 SNOMEDCT_US_2016_03_01:2904007 UMLS_CUI:C0021364 disease_ontology DOID:12336 male infertility DOID:1234 A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as. ICD10CM:F64.2 ICD9CM:302.6 ICD9CM:302.8 ICD9CM:302.85 ICD9CM:302.89 SNOMEDCT_US_2016_03_01:5095008 UMLS_CUI:C0029825 UMLS_CUI:C0154467 UMLS_CUI:C0236802 disease_ontology DOID:1234 gender identity disorder DOID:12347 An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue. DOID:14708 ICD10CM:Q78.0 ICD9CM:756.51 MESH:D010013 NCI:C26837 NCI:C99003 OMIM:PS166200 ORDO:666 SNOMEDCT_US_2016_03_01:157008000 SNOMEDCT_US_2016_03_01:205492005 SNOMEDCT_US_2016_03_01:205493000 SNOMEDCT_US_2016_03_01:205494006 SNOMEDCT_US_2016_03_01:205498009 SNOMEDCT_US_2016_03_01:254105005 SNOMEDCT_US_2016_03_01:254106006 SNOMEDCT_US_2016_03_01:254107002 SNOMEDCT_US_2016_03_01:254108007 SNOMEDCT_US_2016_03_01:254109004 SNOMEDCT_US_2016_03_01:268352002 SNOMEDCT_US_2016_03_01:3508009 SNOMEDCT_US_2016_03_01:385482004 SNOMEDCT_US_2016_03_01:78314001 UMLS_CUI:C0023931 UMLS_CUI:C0029434 Lobstein's syndrome Osteopsathyrosis Vrolik's disease brittle bone disease disease_ontology Fragilitas ossium DOID:12347 Xref MGI. OMIM mapping confirmed by DO. [SN]. osteogenesis imperfecta DOID:12361 An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland. EFO:0004237 ICD10CM:E05.0 MESH:D006111 NCI:C3071 OMIM:275000 OMIM:300351 OMIM:603388 SNOMEDCT_US_2016_03_01:154655004 SNOMEDCT_US_2016_03_01:190240002 SNOMEDCT_US_2016_03_01:237510004 SNOMEDCT_US_2016_03_01:237823003 SNOMEDCT_US_2016_03_01:267464006 SNOMEDCT_US_2016_03_01:353295004 SNOMEDCT_US_2016_03_01:367367004 SNOMEDCT_US_2016_03_01:367449005 SNOMEDCT_US_2016_03_01:38591003 SNOMEDCT_US_2016_03_01:55807009 UMLS_CUI:C0018213 Grave's disease Graves disease exophthalmic goiter disease_ontology Basedow's disease DOID:12361 Xref MGI. OMIM mapping confirmed by DO. [SN]. Graves' disease DOID:12365 A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. DOID:12552 EFO:0001068 ICD10CM:B54 ICD9CM:084 ICD9CM:084.6 MESH:D008288 NCI:C34797 OMIM:609148 SNOMEDCT_US_2016_03_01:105649009 SNOMEDCT_US_2016_03_01:154374002 SNOMEDCT_US_2016_03_01:186797008 SNOMEDCT_US_2016_03_01:187510004 SNOMEDCT_US_2016_03_01:248437004 SNOMEDCT_US_2016_03_01:61462000 UMLS_CUI:C0024530 induced malaria disease_ontology DOID:12365 Xref MGI. malaria DOID:1237 ICD10CM:H18.4 ICD10CM:H18.40 ICD9CM:371.4 ICD9CM:371.40 SNOMEDCT_US_2016_03_01:111521006 SNOMEDCT_US_2016_03_01:193824006 SNOMEDCT_US_2016_03_01:193830006 UMLS_CUI:C0155118 disease_ontology DOID:1237 corneal degeneration DOID:12375 A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses. ICD10CM:J18.0 ICD9CM:485 MESH:D001996 NCI:C26710 SNOMEDCT_US_2016_03_01:155551009 SNOMEDCT_US_2016_03_01:195914001 SNOMEDCT_US_2016_03_01:266352008 SNOMEDCT_US_2016_03_01:396285007 SNOMEDCT_US_2016_03_01:67814005 UMLS_CUI:C0006285 Chest infection - unspecified bronchopneumonia bronchial pneumonia lobular pneumonia disease_ontology DOID:12375 bronchopneumonia DOID:12377 A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy. ICD10CM:G12.9 ICD9CM:335.1 ICD9CM:335.10 MESH:D009134 NCI:C85075 SNOMEDCT_US_2016_03_01:192885003 SNOMEDCT_US_2016_03_01:192887006 SNOMEDCT_US_2016_03_01:5262007 UMLS_CUI:C0026847 disease_ontology DOID:12377 spinal muscular atrophy DOID:12384 An intestinal infectious disease that involves inflammation of the intestines, especially colon, due to chemical irritants, bacteria, protozoa, or parasitic worms, which results in severe diarrhea with passage of mucus and blood. ICD9CM:009.2 MESH:D004403 SNOMEDCT_US_2016_03_01:111939009 SNOMEDCT_US_2016_03_01:154268000 SNOMEDCT_US_2016_03_01:154279005 SNOMEDCT_US_2016_03_01:186165000 SNOMEDCT_US_2016_03_01:186167008 SNOMEDCT_US_2016_03_01:19213003 SNOMEDCT_US_2016_03_01:236076004 SNOMEDCT_US_2016_03_01:266173000 SNOMEDCT_US_2016_03_01:266180003 UMLS_CUI:C0013369 Infectious diarrhea disease_ontology DOID:12384 dysentery DOID:12385 A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces. DOID:11378 DOID:12950 DOID:2041 DOID:924 DOID:925 ICD10CM:A03 ICD10CM:A03.0 ICD10CM:A03.1 ICD10CM:A03.2 ICD10CM:A03.9 ICD9CM:004 ICD9CM:004.0 ICD9CM:004.1 ICD9CM:004.2 ICD9CM:004.3 ICD9CM:004.9 KEGG:05131 MESH:D004405 SNOMEDCT_US_2016_03_01:111817006 SNOMEDCT_US_2016_03_01:154272001 SNOMEDCT_US_2016_03_01:186104004 SNOMEDCT_US_2016_03_01:186105003 SNOMEDCT_US_2016_03_01:186108001 SNOMEDCT_US_2016_03_01:187272003 SNOMEDCT_US_2016_03_01:266175007 SNOMEDCT_US_2016_03_01:34335000 SNOMEDCT_US_2016_03_01:36188001 SNOMEDCT_US_2016_03_01:55760004 SNOMEDCT_US_2016_03_01:66301008 UMLS_CUI:C0013371 UMLS_CUI:C0302358 UMLS_CUI:C0302359 UMLS_CUI:C0302360 UMLS_CUI:C0302361 Shigella boydii infectious disease Shigella flexneri infectious disease Shigella gastroenteritis Shigella sonnei infectious disease bacillary dysentery disease_ontology DOID:12385 shigellosis DOID:12387 An impaired renal function disease characterized by a complete or partial resistance of the kidneys to vasopressin (ADH). ICD10CM:N25.1 ICD9CM:588.1 MESH:D018500 NCI:C84919 OMIM:125800 OMIM:304800 ORDO:223 SNOMEDCT_US_2016_03_01:111395007 SNOMEDCT_US_2016_03_01:123294004 UMLS_CUI:C0162283 disease_ontology vasopressin-resistant diabetes insipidus DOID:12387 Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS]. nephrogenic diabetes insipidus DOID:12388 MESH:D020790 NCI:C84933 OMIM:125700 OMIM:304900 SNOMEDCT_US_2016_03_01:154699008 SNOMEDCT_US_2016_03_01:15771004 SNOMEDCT_US_2016_03_01:190484000 SNOMEDCT_US_2016_03_01:267393007 SNOMEDCT_US_2016_03_01:45369008 SNOMEDCT_US_2016_03_01:64410003 UMLS_CUI:C0687720 Pituitary diabetes insipidus Vasopressin deficiency central diabetes insipidus vasopressin defective diabetes insipidus disease_ontology DOID:12388 OMIM mapping confirmed by DO. [SN]. neurohypophyseal diabetes insipidus DOID:12397 DOID:14446 ICD9CM:374.00 MESH:D004774 SNOMEDCT_US_2016_03_01:155177005 SNOMEDCT_US_2016_03_01:193928005 SNOMEDCT_US_2016_03_01:246821008 SNOMEDCT_US_2016_03_01:33168009 UMLS_CUI:C0014390 disease_ontology DOID:12397 entropion DOID:12399 An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life. ICD10CM:F63.0 ICD9CM:312.31 MESH:D005715 NCI:C94335 OMIM:606349 SNOMEDCT_US_2016_03_01:18085000 SNOMEDCT_US_2016_03_01:192501004 SNOMEDCT_US_2016_03_01:284524008 UMLS_CUI:C0030662 Compulsive gambling Pathological gambling disease_ontology DOID:12399 OMIM mapping confirmed by DO. [SN]. pathological gambling DOID:1240 A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells. DOID:9145 ICD10CM:C95 ICD10CM:C95.9 ICD10CM:C95.90 ICD9CM:208 ICD9CM:208.9 MESH:D007938 NCI:C3161 SNOMEDCT_US_2016_03_01:154598008 SNOMEDCT_US_2016_03_01:188762002 SNOMEDCT_US_2016_03_01:188767008 SNOMEDCT_US_2016_03_01:190024009 SNOMEDCT_US_2016_03_01:190025005 SNOMEDCT_US_2016_03_01:190029004 SNOMEDCT_US_2016_03_01:190071003 SNOMEDCT_US_2016_03_01:255049003 SNOMEDCT_US_2016_03_01:87163000 SNOMEDCT_US_2016_03_01:93143009 UMLS_CUI:C0023418 disease_ontology DOID:1240 leukemia DOID:12401 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness. DOID:9404 ICD10CM:F60.3 ICD10CM:F63.81 ICD9CM:301.3 ICD9CM:312.34 MESH:D007174 NCI:C94332 SNOMEDCT_US_2016_03_01:191759005 SNOMEDCT_US_2016_03_01:192096007 SNOMEDCT_US_2016_03_01:192488005 SNOMEDCT_US_2016_03_01:231527003 SNOMEDCT_US_2016_03_01:268757006 SNOMEDCT_US_2016_03_01:40987004 UMLS_CUI:C0021776 UMLS_CUI:C0152183 explosive personality disorder disease_ontology DOID:12401 intermittent explosive disorder DOID:1242 ICD10CM:H44.39 ICD9CM:360.29 SNOMEDCT_US_2016_03_01:194638007 UMLS_CUI:C0154780 disease_ontology DOID:1242 globe disease DOID:12449 An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow. ICD10CM:D61.9 ICD9CM:284.9 MESH:D000741 NCI:C2870 OMIM:609135 SNOMEDCT_US_2016_03_01:154807001 SNOMEDCT_US_2016_03_01:191233006 SNOMEDCT_US_2016_03_01:191258001 SNOMEDCT_US_2016_03_01:267560004 SNOMEDCT_US_2016_03_01:304132006 SNOMEDCT_US_2016_03_01:305047005 SNOMEDCT_US_2016_03_01:306058006 SNOMEDCT_US_2016_03_01:79000000 UMLS_CUI:C0002874 disease_ontology DOID:12449 OMIM mapping confirmed by DO. [SN]. aplastic anemia DOID:1245 DOID:1282 ICD10CM:C51 ICD10CM:C51.9 ICD9CM:184.4 MESH:D014846 NCI:C3443 NCI:C7502 SNOMEDCT_US_2016_03_01:126922007 SNOMEDCT_US_2016_03_01:154535008 SNOMEDCT_US_2016_03_01:188214009 SNOMEDCT_US_2016_03_01:269471005 SNOMEDCT_US_2016_03_01:269604005 SNOMEDCT_US_2016_03_01:363367000 SNOMEDCT_US_2016_03_01:94143002 UMLS_CUI:C0042995 UMLS_CUI:C0375071 Ca vulva Vulvar tumor malignant Vulvar tumor malignant neoplasm of vulva unspecified malignant neoplasm of vulva unspecified (disorder) malignant neoplasm of vulva, NOS malignant neoplasm of vulva, unspecified malignant tumor of vulva (disorder) neoplasm of vulva (disorder) vulval cancer vulval neoplasm vulvar neoplasm disease_ontology DOID:1245 vulva cancer DOID:12450 ICD10CM:D61.81 ICD9CM:284.1 MESH:D010198 NCI:C34889 NCI:C80693 SNOMEDCT_US_2016_03_01:127034005 SNOMEDCT_US_2016_03_01:191250008 SNOMEDCT_US_2016_03_01:267528007 UMLS_CUI:C0030312 disease_ontology DOID:12450 pancytopenia DOID:12466 MESH:D006962 NCI:C113335 SNOMEDCT_US_2016_03_01:91478007 UMLS_CUI:C0020503 secondary hyperparathyroidism (disorder) secondary hyperparathyroidism NOS disease_ontology DOID:12466 secondary hyperparathyroidism DOID:1247 DOID:13997 DOID:9474 ICD10CM:D68.9 ICD9CM:286 MESH:D001778 NCI:C2902 SNOMEDCT_US_2016_03_01:127073005 SNOMEDCT_US_2016_03_01:154815003 SNOMEDCT_US_2016_03_01:191303002 SNOMEDCT_US_2016_03_01:267562007 SNOMEDCT_US_2016_03_01:362970003 SNOMEDCT_US_2016_03_01:64779008 UMLS_CUI:C0005779 postpartum coagulation defect postpartum coagulation defect with delivery disease_ontology DOID:1247 blood coagulation disease DOID:12506 A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve). ICD10CM:G51.0 ICD9CM:351.0 MESH:D020330 SNOMEDCT_US_2016_03_01:155070005 SNOMEDCT_US_2016_03_01:193093009 SNOMEDCT_US_2016_03_01:267703001 SNOMEDCT_US_2016_03_01:79359001 UMLS_CUI:C0376175 Bell palsy Bell's (facial) palsy disease_ontology DOID:12506 Bell's palsy DOID:12510 ICD10CM:H35.82 ICD9CM:362.84 SNOMEDCT_US_2016_03_01:193427006 SNOMEDCT_US_2016_03_01:26468004 UMLS_CUI:C0162291 disease_ontology DOID:12510 retinal ischemia DOID:12557 ICD10CM:H50.81 ICD9CM:378.71 MESH:D004370 NCI:C84678 OMIM:126800 OMIM:604356 SNOMEDCT_US_2016_03_01:60318001 UMLS_CUI:C0013261 Duane's syndrome Stilling-Turk-Duane syndrome disease_ontology DOID:12557 OMIM mapping confirmed by DO. [SN]. Duane retraction syndrome DOID:12558 ICD10CM:H49.4 ICD9CM:378.72 MESH:D017246 SNOMEDCT_US_2016_03_01:194034008 SNOMEDCT_US_2016_03_01:194126004 SNOMEDCT_US_2016_03_01:46252003 UMLS_CUI:C0162674 chronic progressive external ophthalmoplegia [Ambiguous] progressive external ophthalmoplegia progressive external ophthalmoplegia (disorder) disease_ontology DOID:12558 chronic progressive external ophthalmoplegia DOID:12568 A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page. Mathematics disorder disorder of arithmetical skills disease_ontology DOID:12568 dyscalculia DOID:12570 ICD9CM:365.51 SNOMEDCT_US_2016_03_01:32893002 UMLS_CUI:C0152137 disease_ontology DOID:12570 phacolytic glaucoma DOID:12571 ICD9CM:365.59 SNOMEDCT_US_2016_03_01:84333006 UMLS_CUI:C0154959 disease_ontology DOID:12571 phacogenic glaucoma DOID:12574 MESH:D015866 NCI:C35111 SNOMEDCT_US_2016_03_01:193451001 SNOMEDCT_US_2016_03_01:43363007 SNOMEDCT_US_2016_03_01:46627006 UMLS_CUI:C0042167 Uveitis, posterior disease_ontology DOID:12574 posterior uveitis DOID:12577 MESH:D014524 NCI:C79804 SNOMEDCT_US_2016_03_01:95588004 UMLS_CUI:C0041972 Obstruction of urethra (disorder) disease_ontology DOID:12577 urethral obstruction DOID:12580 ICD10CM:Q93.4 ICD9CM:758.31 MESH:D003410 NCI:C34518 OMIM:123450 SNOMEDCT_US_2016_03_01:70173007 UMLS_CUI:C0010314 5p deletion syndrome 5p partial monosomy syndrome (disorder) Cri-du-chat syndrome chromosome 5 short arm deletion syndrome chromosome 5p deletion syndrome disease_ontology DOID:12580 OMIM mapping confirmed by DO. [SN]. Cri-Du-Chat syndrome DOID:12581 ICD10CM:M70.2 ICD9CM:726.33 SNOMEDCT_US_2016_03_01:156680002 SNOMEDCT_US_2016_03_01:202930004 SNOMEDCT_US_2016_03_01:270542002 SNOMEDCT_US_2016_03_01:424548006 SNOMEDCT_US_2016_03_01:425940002 SNOMEDCT_US_2016_03_01:63517006 SNOMEDCT_US_2016_03_01:74859007 SNOMEDCT_US_2016_03_01:77299006 UMLS_CUI:C0263962 Bursitis of elbow Bursitis of elbow region Capped elbow Elbow bursitis (& olecranon) Miner's elbow Miners' elbow Shoe boil disease_ontology DOID:12581 olecranon bursitis DOID:12583 A chromosomal disease that has_material_basis_in deletion polymorphisms at chromosome location 22q11 and is characterized by variable developmental problems and schizoid features. ICD10CM:Q93.81 ICD9CM:758.32 MESH:D004062 OMIM:192430 SNOMEDCT_US_2016_03_01:205642004 SNOMEDCT_US_2016_03_01:83092002 UMLS_CUI:C0220704 22q11 Deletion Syndrome Shprintzen syndrome VCF-Velocardiofacial syndrome deletion 22q11.2 syndrome disease_ontology DOID:12583 OMIM mapping confirmed by DO. [LS]. velocardiofacial syndrome DOID:12639 ICD10CM:K31.1 MESH:D011707 NCI:C34966 SNOMEDCT_US_2016_03_01:367403001 UMLS_CUI:C0034194 disease_ontology DOID:12639 pyloric stenosis DOID:12661 ICD10CM:K03.5 ICD9CM:521.6 MESH:D020254 OMIM:157950 SNOMEDCT_US_2016_03_01:14901003 UMLS_CUI:C0155930 Ankylosis of teeth Ankylosis of tooth (disorder) disease_ontology DOID:12661 OMIM mapping confirmed by DO. [LS]. tooth ankylosis DOID:12662 A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis. ICD10CM:B41 ICD10CM:B41.9 ICD9CM:116.1 MESH:D010229 NCI:C34891 SNOMEDCT_US_2016_03_01:187074005 SNOMEDCT_US_2016_03_01:187486002 SNOMEDCT_US_2016_03_01:36866003 SNOMEDCT_US_2016_03_01:59925007 UMLS_CUI:C0030409 Mucocutaneous-lymphangitic paracoccidioidomycosis Mucocutaneous-lymphangitic paracoccidioidomycosis (disorder) Paracoccidioidomycosis (disorder) Paracoccidioidomycosis NOS (disorder) Paracoccidioidomycosis, unspecified (disorder) paracoccidioidal mycosis disease_ontology DOID:12662 paracoccidioidomycosis DOID:12663 A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening. DOID:13067 CSP:1988-4119 ICD10CM:B40 ICD10CM:B40.9 ICD9CM:116 ICD9CM:116.0 MESH:D001759 NCI:C34428 NCI:C34429 SNOMEDCT_US_2016_03_01:10673008 SNOMEDCT_US_2016_03_01:154402000 SNOMEDCT_US_2016_03_01:187064007 SNOMEDCT_US_2016_03_01:187071002 SNOMEDCT_US_2016_03_01:187075006 SNOMEDCT_US_2016_03_01:187484004 SNOMEDCT_US_2016_03_01:191950004 SNOMEDCT_US_2016_03_01:266217003 SNOMEDCT_US_2016_03_01:69996000 UMLS_CUI:C0005716 Blastomyces Dermatitidis Infection Blastomycotic infection Chicago disease Gilchrist's disease Infection by Blastomyces dermatitidis North American blastomycosis disease_ontology DOID:12663 blastomycosis DOID:12678 ICD10CM:E83.52 ICD9CM:275.42 MESH:D006934 NCI:C3112 SNOMEDCT_US_2016_03_01:154752005 SNOMEDCT_US_2016_03_01:166702002 SNOMEDCT_US_2016_03_01:267505006 SNOMEDCT_US_2016_03_01:66931009 UMLS_CUI:C0020437 disease_ontology DOID:12678 hypercalcemia DOID:12679 MESH:D009397 NCI:C84918 SNOMEDCT_US_2016_03_01:154752005 SNOMEDCT_US_2016_03_01:190863003 SNOMEDCT_US_2016_03_01:267505006 SNOMEDCT_US_2016_03_01:48638002 UMLS_CUI:C0027709 disease_ontology DOID:12679 nephrocalcinosis DOID:12698 ICD10CM:N62 MESH:D006177 NCI:C3073 SNOMEDCT_US_2016_03_01:155963008 SNOMEDCT_US_2016_03_01:198112004 SNOMEDCT_US_2016_03_01:266646002 SNOMEDCT_US_2016_03_01:4754008 UMLS_CUI:C0018418 disease_ontology DOID:12698 gynecomastia DOID:127 A cell type benign neoplasm that is a benign tumor of smooth muscle cells. MESH:D007889 NCI:C3157 SNOMEDCT_US_2016_03_01:189787000 SNOMEDCT_US_2016_03_01:189788005 SNOMEDCT_US_2016_03_01:189793008 SNOMEDCT_US_2016_03_01:702978006 UMLS_CUI:C0023267 leiomyomatous neoplasm (morphologic abnormality) leiomyomatous tumor disease_ontology DOID:127 leiomyoma DOID:1270 An autosomal dominant disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins. ICD10CM:I78.0 ICD9CM:448.0 MESH:D013683 NCI:C35064 OMIM:187300 OMIM:600376 OMIM:601101 OMIM:615506 ORDO:774 SNOMEDCT_US_2016_03_01:155449008 SNOMEDCT_US_2016_03_01:21877004 SNOMEDCT_US_2016_03_01:266324004 UMLS_CUI:C0039445 Osler hemorrhagic telangiectasia syndrome Osler-Weber-Rendu disease Rendu-Osler-Weber disease disease_ontology DOID:1270 Xref MGI. OMIM mapping confirmed by DO. [SN]. hereditary hemorrhagic telangiectasia DOID:12700 An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood. DOID:12699 ICD10CM:E22.1 MESH:D002640 MESH:D006966 NCI:C113168 SNOMEDCT_US_2016_03_01:190468001 SNOMEDCT_US_2016_03_01:21170004 SNOMEDCT_US_2016_03_01:237662005 SNOMEDCT_US_2016_03_01:367422005 SNOMEDCT_US_2016_03_01:85039006 UMLS_CUI:C0008043 UMLS_CUI:C0020514 Chiari-Frommel syndrome Pregnancy-related A-G syndrome (disorder) hyperprolactinaemia disease_ontology DOID:12700 hyperprolactinemia DOID:12704 MESH:D001260 NCI:C2887 OMIM:208900 SNOMEDCT_US_2016_03_01:68504005 UMLS_CUI:C0004135 Boder-Sedgwick syndrome Louis Bar syndrome disease_ontology DOID:12704 OMIM mapping confirmed by DO. [SN]. ataxia telangiectasia DOID:12705 DOID:0050555 ICD9CM:334.0 MESH:D005621 NCI:C84718 OMIM:229300 OMIM:601992 SNOMEDCT_US_2016_03_01:10394003 SNOMEDCT_US_2016_03_01:155011003 UMLS_CUI:C0016719 Friedreich ataxia 1 Friedreich's ataxia Friedreich's tabes disease_ontology DOID:12705 Xref MGI. Friedreich ataxia DOID:1271 A vascular disease that is located_in the capillaries. ICD10CM:I78 ICD10CM:I78.9 ICD9CM:448 SNOMEDCT_US_2016_03_01:155446001 SNOMEDCT_US_2016_03_01:155449008 SNOMEDCT_US_2016_03_01:195250004 SNOMEDCT_US_2016_03_01:195380006 SNOMEDCT_US_2016_03_01:195390003 SNOMEDCT_US_2016_03_01:266324004 SNOMEDCT_US_2016_03_01:57223003 SNOMEDCT_US_2016_03_01:58729003 UMLS_CUI:C0155765 disease of capillaries disease_ontology DOID:1271 capillary disease DOID:12712 An autosomal recessive disease that is characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form) resulting from dysfunction of ciliary proteins (ciliopathy). ICD10CM:Q61.5 NCI:C123200 OMIM:256100 OMIM:602088 OMIM:604387 OMIM:606966 OMIM:611498 OMIM:613159 OMIM:613550 OMIM:613820 OMIM:613824 OMIM:614377 OMIM:614844 OMIM:614845 OMIM:615382 OMIM:615862 OMIM:616217 ORDO:655 SNOMEDCT_US_2016_03_01:204958008 SNOMEDCT_US_2016_03_01:204961009 UMLS_CUI:C0687120 medullary cystic disease medullary cystic kidney disease_ontology DOID:12712 Xref MGI. OMIM mapping confirmed by DO. [SN]. nephronophthisis DOID:12714 ICD10CM:Q77.6 ICD9CM:756.55 MESH:D004613 NCI:C84684 OMIM:225500 SNOMEDCT_US_2016_03_01:62501005 UMLS_CUI:C0013903 Chondroectodermal dysplasia Chondroectodermal dysplasia (disorder) Ellis-van Creveld syndrome disease_ontology DOID:12714 OMIM mapping confirmed by DO. [SN]. Ellis-Van Creveld syndrome DOID:12716 A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts. DOID:11395 DOID:13859 ICD10CM:P22.0 MESH:D006819 OMIM:267450 SNOMEDCT_US_2016_03_01:206281003 SNOMEDCT_US_2016_03_01:26168007 SNOMEDCT_US_2016_03_01:46775006 UMLS_CUI:C0020192 HMD - Hyaline membrane disease Neonatal respiratory Distress syndrome hyaline membrane disease pulmonary hyaline membrane disease pulmonary hypoperfusion syndrome of newborn respiratory distress syndrome of newborn disease_ontology DOID:12716 newborn respiratory distress syndrome DOID:1272 MESH:D013684 NCI:C28194 SNOMEDCT_US_2016_03_01:112641009 SNOMEDCT_US_2016_03_01:155449008 SNOMEDCT_US_2016_03_01:247479008 SNOMEDCT_US_2016_03_01:266324004 SNOMEDCT_US_2016_03_01:276328002 UMLS_CUI:C0039446 telangiectasia disease_ontology DOID:1272 telangiectasis DOID:12733 ICD10CM:K03.4 ICD9CM:521.5 MESH:D006936 SNOMEDCT_US_2016_03_01:78537008 UMLS_CUI:C0020441 Cementation hyperplasia disease_ontology DOID:12733 hypercementosis DOID:12753 ICD10CM:H18.72 ICD9CM:371.73 SNOMEDCT_US_2016_03_01:193849005 SNOMEDCT_US_2016_03_01:52476003 UMLS_CUI:C0152440 disease_ontology DOID:12753 corneal staphyloma DOID:12783 A migraine that is characterized by migraine headaches that are not accompanied by an aura. ICD10CM:G43.0 ICD10CM:G43.009 ICD9CM:346.1 MESH:D020326 NCI:C117004 OMIM:607501 SNOMEDCT_US_2016_03_01:193027003 SNOMEDCT_US_2016_03_01:193029000 SNOMEDCT_US_2016_03_01:56097005 UMLS_CUI:C0338480 common migraine disease_ontology DOID:12783 Xref MGI. migraine without aura DOID:12785 ICD9CM:357.2 MESH:D003929 SNOMEDCT_US_2016_03_01:190349003 SNOMEDCT_US_2016_03_01:193182005 SNOMEDCT_US_2016_03_01:49455004 UMLS_CUI:C0271680 Diabetes mellitus with polyneuropathy Diabetic polyneuropathy (disorder) Polyneuropathy in diabetes disease_ontology DOID:12785 diabetic polyneuropathy DOID:1279 ICD9CM:378.9 MESH:D015835 SNOMEDCT_US_2016_03_01:45030009 UMLS_CUI:C0028850 disorder of eye movements eye movement disorder disease_ontology DOID:1279 ocular motility disease DOID:12798 A lysosomal storage disease that involves the accumulation of glycosaminoglycans in the tissues and their excretion in the urine. DOID:14716 ICD10CM:E76.3 ICD9CM:277.5 MESH:D009083 NCI:C61259 OMIM:252700 OMIM:607014 ORDO:79213 SNOMEDCT_US_2016_03_01:11380006 SNOMEDCT_US_2016_03_01:190936000 SNOMEDCT_US_2016_03_01:190942001 SNOMEDCT_US_2016_03_01:267452003 UMLS_CUI:C0026703 disease_ontology DOID:12798 Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS]. mucopolysaccharidosis DOID:12799 A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme iduronate sulfatase. ICD10CM:E76.1 MESH:D016532 NCI:C61260 OMIM:309900 SNOMEDCT_US_2016_03_01:190936000 SNOMEDCT_US_2016_03_01:61413000 SNOMEDCT_US_2016_03_01:70737009 UMLS_CUI:C0026705 Hunter syndrome Hunter's syndrome MPS II - Hunter syndrome Mucopolysaccharidosis, MPS-II (disorder) deficiency of iduronate-2-sulphatase disease_ontology DOID:12799 OMIM mapping submitted by NeuroDevNet. [LS]. mucopolysaccharidosis II DOID:12800 A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase. MESH:D009087 NCI:C61264 OMIM:253200 SNOMEDCT_US_2016_03_01:190936000 SNOMEDCT_US_2016_03_01:52677002 SNOMEDCT_US_2016_03_01:69463008 UMLS_CUI:C0026709 MPS VI - Maroteaux-Lamy syndrome Maroteaux - Lamy syndrome Maroteaux-Lamy syndrome arylsulfatase B deficiency deficiency of N-acetylgalactosamine-4-sulfatase (disorder) disease_ontology DOID:12800 OMIM mapping confirmed by DO. [SN]. mucopolysaccharidosis VI DOID:12804 A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzymes galactose 6-sulfate sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain. DOID:14767 ICD10CM:E76.210 ICD10CM:E76.219 MESH:D009085 NCI:C61263 NCI:C84901 OMIM:253000 OMIM:253010 SNOMEDCT_US_2016_03_01:124449003 SNOMEDCT_US_2016_03_01:130197005 SNOMEDCT_US_2016_03_01:190936000 SNOMEDCT_US_2016_03_01:254074007 SNOMEDCT_US_2016_03_01:378007 SNOMEDCT_US_2016_03_01:7259005 SNOMEDCT_US_2016_03_01:78856008 UMLS_CUI:C0026707 UMLS_CUI:C0086651 Mucopolysaccharidosis, MPS-IV deficiency of N-acetylgalactosamine-6-sulphatase deficiency of chondroitinsulphatase galactosamine-6-sulfatase deficiency MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Morquio A disease Morquio syndrome A Mucopolysaccharidosis type IVB Mucopolysaccharidosis, MPS-IV-A (disorder) Osteochondrodystrophy chondroosteodystrophy mucopolysaccharidosis type IVA disease_ontology DOID:12804 OMIM mapping confirmed by DO. [SN]. mucopolysaccharidosis IV DOID:1283 ICD10CM:K46 ICD10CM:N81.5 ICD9CM:618.6 MESH:D006547 SNOMEDCT_US_2016_03_01:198272003 SNOMEDCT_US_2016_03_01:198275001 SNOMEDCT_US_2016_03_01:270884000 SNOMEDCT_US_2016_03_01:398061002 SNOMEDCT_US_2016_03_01:47671001 UMLS_CUI:C0205792 vaginal enterocele disease_ontology DOID:1283 enterocele DOID:12835 ICD10CM:G82.5 ICD10CM:G82.50 ICD9CM:344.00 MESH:D011782 NCI:C50721 SNOMEDCT_US_2016_03_01:11538006 SNOMEDCT_US_2016_03_01:155030003 UMLS_CUI:C0034372 tetraplegia disease_ontology DOID:12835 quadriplegia DOID:1284 ICD9CM:618.8 ICD9CM:618.89 UMLS_CUI:C0029801 disease_ontology DOID:1284 prolapse of female genital organ DOID:12849 An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years. EFO:0003758 ICD10CM:F84.0 ICD9CM:299.0 MESH:D001321 NCI:C97161 OMIM:209850 OMIM:300425 OMIM:300495 OMIM:300496 OMIM:300830 OMIM:300847 OMIM:300872 OMIM:607373 OMIM:608049 OMIM:608636 OMIM:609378 OMIM:610676 OMIM:610836 OMIM:610908 OMIM:611015 OMIM:611016 OMIM:611913 OMIM:612100 OMIM:613410 OMIM:613436 OMIM:615032 OMIM:615091 ORDO:106 SNOMEDCT_US_2016_03_01:154878007 SNOMEDCT_US_2016_03_01:191688000 SNOMEDCT_US_2016_03_01:191691000 SNOMEDCT_US_2016_03_01:192581001 SNOMEDCT_US_2016_03_01:271450003 SNOMEDCT_US_2016_03_01:34883005 SNOMEDCT_US_2016_03_01:38763009 SNOMEDCT_US_2016_03_01:408856003 SNOMEDCT_US_2016_03_01:408857007 SNOMEDCT_US_2016_03_01:43614003 UMLS_CUI:C0004352 Kanner's syndrome autism autistic disorder of childhood onset childhood autism infantile autism disease_ontology DOID:12849 Xref MGI. OMIM mapping confirmed by DO. [SN]. autistic disorder DOID:1285 MESH:D012002 SNOMEDCT_US_2016_03_01:5964004 UMLS_CUI:C0034882 disease_ontology DOID:1285 rectal disease DOID:12858 A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities. ICD10CM:G10 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 SNOMEDCT_US_2016_03_01:155006000 SNOMEDCT_US_2016_03_01:58756001 UMLS_CUI:C0020179 HD Huntington disease Huntington's chorea disease_ontology DOID:12858 Huntington's disease DOID:12859 A movement disease characterized by brief, semi-directed, irregular movements that not repetitive or rhythmic, but appear to flow from one muscle to the next. ICD10CM:G25.5 OMIM:118700 OMIM:215450 ORDO:1429 chorea hereditary chorea disease_ontology DOID:12859 Xref MGI. choreatic disease DOID:1287 A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. DOID:73 ICD9CM:429.2 MESH:D002318 NCI:C2931 SNOMEDCT_US_2016_03_01:155263000 SNOMEDCT_US_2016_03_01:194707003 SNOMEDCT_US_2016_03_01:195139006 SNOMEDCT_US_2016_03_01:195594006 SNOMEDCT_US_2016_03_01:266275004 SNOMEDCT_US_2016_03_01:266336005 SNOMEDCT_US_2016_03_01:49601007 UMLS_CUI:C0007222 disease of subdivision of hemolymphoid system disease_ontology DOID:1287 cardiovascular system disease DOID:1289 A central nervous system disease that results_in the progressive deterioration of function or structure of neurons. DOID:4874 ICD10CM:G31.9 MESH:D019636 NCI:C27090 SNOMEDCT_US_2016_03_01:362975008 UMLS_CUI:C0524851 UMLS_CUI:C1285162 Neurodegenerative disease degenerative disease disease_ontology DOID:1289 neurodegenerative disease DOID:12897 MESH:D013364 UMLS_CUI:C0038557 disease_ontology DOID:12897 submandibular gland disease DOID:12905 ICD10CM:K11.5 ICD9CM:527.5 MESH:D015494 NCI:C34994 SNOMEDCT_US_2016_03_01:109767003 SNOMEDCT_US_2016_03_01:155656006 SNOMEDCT_US_2016_03_01:196507003 SNOMEDCT_US_2016_03_01:28826002 UMLS_CUI:C0036091 Salivary gland Stone Sialolith Stone of salivary gland or duct disease_ontology DOID:12905 sialolithiasis DOID:12930 An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently. EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 SNOMEDCT_US_2016_03_01:195018001 SNOMEDCT_US_2016_03_01:195021004 SNOMEDCT_US_2016_03_01:389995008 SNOMEDCT_US_2016_03_01:399020009 SNOMEDCT_US_2016_03_01:74368002 UMLS_CUI:C0007193 primary dilated cardiomyopathy disease_ontology Congestive cardiomyopathy Familial dilated cardiomyopathy Idiopathic dilation cardiomyopathy DOID:12930 Xref MGI. OMIM mapping confirmed by DO. [LS]. dilated cardiomyopathy DOID:12932 ICD9CM:425.0 MESH:D004719 NCI:C34585 SNOMEDCT_US_2016_03_01:111507009 SNOMEDCT_US_2016_03_01:123264005 SNOMEDCT_US_2016_03_01:155351008 SNOMEDCT_US_2016_03_01:266301006 SNOMEDCT_US_2016_03_01:30293000 SNOMEDCT_US_2016_03_01:398716006 UMLS_CUI:C0553980 (Becker's disease) or (obscure African cardiomyopathy) African endomyocardial fibrosis Becker's disease Endomyocardial sclerosis Obscure African cardiomyopathy (disorder) disease_ontology DOID:12932 endomyocardial fibrosis DOID:1294 A vulva cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C4866 UMLS_CUI:C0677055 Vulvar carcinoma disease_ontology carcinoma of vulva DOID:1294 vulva carcinoma DOID:12959 ICD10CM:H02.2 ICD10CM:H02.20 ICD9CM:374.2 ICD9CM:374.20 SNOMEDCT_US_2016_03_01:193936001 SNOMEDCT_US_2016_03_01:193937005 SNOMEDCT_US_2016_03_01:193941009 SNOMEDCT_US_2016_03_01:60735000 UMLS_CUI:C0152226 disease_ontology DOID:12959 lagophthalmos DOID:12960 A synostosis that results_in craniosynostosis and syndactyly. DOID:0080004 ICD9CM:755.55 MESH:D000168 NCI:C34348 OMIM:101200 SNOMEDCT_US_2016_03_01:205257004 SNOMEDCT_US_2016_03_01:268262006 SNOMEDCT_US_2016_03_01:63661009 UMLS_CUI:C1510455 Apert syndrome disease_ontology DOID:12960 OMIM mapping confirmed by DO. [SN]. acrocephalosyndactylia DOID:12987 ICD10CM:D70 MESH:D000380 NCI:C2863 SNOMEDCT_US_2016_03_01:142919000 SNOMEDCT_US_2016_03_01:154830007 SNOMEDCT_US_2016_03_01:165508008 SNOMEDCT_US_2016_03_01:17182001 SNOMEDCT_US_2016_03_01:191336001 SNOMEDCT_US_2016_03_01:191350006 SNOMEDCT_US_2016_03_01:310589001 SNOMEDCT_US_2016_03_01:417672002 SNOMEDCT_US_2016_03_01:72885007 UMLS_CUI:C0001824 Granulocytopenic disorder Granulopenia granulocytopenia disease_ontology DOID:12987 agranulocytosis DOID:12995 A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated. EFO:0004216 ICD10CM:F91 ICD10CM:F91.9 ICD9CM:312.9 MESH:D019955 NCI:C89329 SNOMEDCT_US_2016_03_01:154945001 SNOMEDCT_US_2016_03_01:192104004 SNOMEDCT_US_2016_03_01:192106002 SNOMEDCT_US_2016_03_01:192597006 SNOMEDCT_US_2016_03_01:192603009 SNOMEDCT_US_2016_03_01:268782006 SNOMEDCT_US_2016_03_01:268785008 SNOMEDCT_US_2016_03_01:430909002 UMLS_CUI:C0149654 disease_ontology DOID:12995 conduct disorder DOID:13003 ICD10CM:G45.0 ICD9CM:435.3 MESH:D014715 SNOMEDCT_US_2016_03_01:155404005 SNOMEDCT_US_2016_03_01:195196001 SNOMEDCT_US_2016_03_01:195199008 SNOMEDCT_US_2016_03_01:266314007 SNOMEDCT_US_2016_03_01:394517009 SNOMEDCT_US_2016_03_01:64009001 UMLS_CUI:C0042568 Vertebro-basilar insufficiency Vertebrobasilar arterial insufficiency Vertebrobasilar artery syndrome Vertebrobasilar artery syndrome (disorder) Vertebrobasilar insufficiency disease_ontology DOID:13003 vertebrobasilar insufficiency DOID:13014 ICD10CM:B30.0 ICD9CM:077.1 NCI:C34590 SNOMEDCT_US_2016_03_01:60548004 UMLS_CUI:C0014493 EKC Epidemic keratoconjunctivitis disease_ontology DOID:13014 shipyard eye DOID:13025 ICD10CM:H35.1 ICD10CM:H35.10 ICD10CM:H35.17 ICD9CM:362.20 ICD9CM:362.21 MESH:D012178 NCI:C34982 SNOMEDCT_US_2016_03_01:155110004 SNOMEDCT_US_2016_03_01:415297005 SNOMEDCT_US_2016_03_01:74277007 UMLS_CUI:C0035344 Retrolental fibroplasia premature retinopathy disease_ontology DOID:13025 retinopathy of prematurity DOID:13034 A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse. ICD10CM:A68 ICD10CM:A68.9 ICD9CM:087 ICD9CM:087.9 MESH:D012061 SNOMEDCT_US_2016_03_01:186820006 SNOMEDCT_US_2016_03_01:186822003 SNOMEDCT_US_2016_03_01:187374004 SNOMEDCT_US_2016_03_01:420079008 SNOMEDCT_US_2016_03_01:46107006 UMLS_CUI:C0035021 disease_ontology DOID:13034 relapsing fever DOID:13036 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy. ICD10CM:A68.1 ICD9CM:087.1 NCI:C34976 SNOMEDCT_US_2016_03_01:10301003 SNOMEDCT_US_2016_03_01:186821005 UMLS_CUI:C0035022 Relapsing fever, tick-borne Tick-borne relapsing fever (disorder) Tick-borne relapsing fever NOS (disorder) disease_ontology DOID:13036 tick-borne relapsing fever DOID:1307 A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. ICD9CM:290.8 UMLS_CUI:C0154319 disease_ontology DOID:1307 dementia DOID:13087 A syndrome that involves pre-excitation of the ventricles due to an accessory pathway providing an abnormal electrical communication from the atria to the ventricles. ICD10CM:I45.6 ICD9CM:426.81 MESH:D008151 ORDO:844 SNOMEDCT_US_2016_03_01:55475008 UMLS_CUI:C0024054 atrial tachyarrhythmia with short PR interval syndrome of short P-R interval, normal QRS complexes, and supraventricular tachycardias disease_ontology DOID:13087 Lown-Ganong-Levine syndrome DOID:13088 ICD10CM:P91.2 ICD9CM:779.7 MESH:D007969 NCI:C99013 SNOMEDCT_US_2016_03_01:230769007 UMLS_CUI:C0023529 disease_ontology DOID:13088 periventricular leukomalacia DOID:13089 MESH:D020765 UMLS_CUI:C0752138 disease_ontology DOID:13089 intracranial arterial disease DOID:13096 MESH:D018860 OMIM:182410 SNOMEDCT_US_2016_03_01:238776001 UMLS_CUI:C0282492 Idiopathic livedo reticularis with systemic involvement (disorder) disease_ontology DOID:13096 Sneddon syndrome DOID:13099 A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots. ICD10CM:I67.5 ICD9CM:437.5 MESH:D009072 NCI:C84895 OMIM:252350 OMIM:300845 OMIM:607151 OMIM:608796 OMIM:614042 OMIM:615750 ORDO:2573 ORDO:280679 ORDO:401945 SNOMEDCT_US_2016_03_01:69116000 SNOMEDCT_US_2016_03_01:89142007 UMLS_CUI:C0026654 progressive intracranial arterial occlusion disease_ontology DOID:13099 Xref MGI. OMIM mapping confirmed by DO. [SN]. Moyamoya disease DOID:13113 ICD9CM:374.04 SNOMEDCT_US_2016_03_01:67383002 UMLS_CUI:C0155191 disease_ontology DOID:13113 cicatricial entropion DOID:13117 A nail disease characterized by often-tender bacterial or fungal hand infection or foot infection due to either bacteria or fungus (Candida albicans) where the nail and skin meet at the side or the base of a finger or toe nail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia). Puss is usually present, along with gradual thickening and browning discoloration of the nail plate. DOID:11398 DOID:9689 ICD10CM:L03.0 MESH:D010304 NCI:C79702 SNOMEDCT_US_2016_03_01:156305000 SNOMEDCT_US_2016_03_01:200643006 SNOMEDCT_US_2016_03_01:267830000 SNOMEDCT_US_2016_03_01:71906005 UMLS_CUI:C0030578 Infected nailfold Onychia and paronychia of finger Onychia and paronychia of toe fungal nail infection disease_ontology paronychia inflammation DOID:13117 paronychia DOID:13141 ICD10CM:H20.9 MESH:D014605 NCI:C26909 SNOMEDCT_US_2016_03_01:128473001 SNOMEDCT_US_2016_03_01:155116005 SNOMEDCT_US_2016_03_01:193499001 SNOMEDCT_US_2016_03_01:267719008 SNOMEDCT_US_2016_03_01:75614007 UMLS_CUI:C0042164 disease_ontology DOID:13141 uveitis DOID:13148 A cystitis characterized by a sudden onset or severe symptoms. ICD10CM:N30.0 ICD9CM:595.0 NCI:C26934 SNOMEDCT_US_2016_03_01:155883005 SNOMEDCT_US_2016_03_01:197833009 SNOMEDCT_US_2016_03_01:266628008 SNOMEDCT_US_2016_03_01:68226007 UMLS_CUI:C0149523 urinary tract infection disease_ontology DOID:13148 acute cystitis DOID:13189 An arthritis that has_material_basis_in uric acid crystal deposits located_in joint. DOID:14144 EFO:0004274 ICD10CM:M10 ICD10CM:M10.9 ICD9CM:274 ICD9CM:274.0 ICD9CM:274.00 ICD9CM:274.9 MESH:D006073 MESH:D015210 NCI:C34650 SNOMEDCT_US_2016_03_01:147966005 SNOMEDCT_US_2016_03_01:154745008 SNOMEDCT_US_2016_03_01:154746009 SNOMEDCT_US_2016_03_01:170733007 SNOMEDCT_US_2016_03_01:190827003 SNOMEDCT_US_2016_03_01:190828008 SNOMEDCT_US_2016_03_01:190844004 SNOMEDCT_US_2016_03_01:201661008 SNOMEDCT_US_2016_03_01:201662001 SNOMEDCT_US_2016_03_01:201672003 SNOMEDCT_US_2016_03_01:48440001 SNOMEDCT_US_2016_03_01:90560007 UMLS_CUI:C0003868 UMLS_CUI:C0018099 Articular gout Gouty arthropathy gouty arthritis disease_ontology DOID:13189 gout DOID:1319 A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain. DOID:2125 DOID:2126 DOID:3543 DOID:6649 DOID:911 CSP:2006-2736 ICD10CM:C71 ICD10CM:C71.9 ICD9CM:191 ICD9CM:191.9 ICD9CM:239.6 MESH:D001932 NCI:C2907 NCI:C3568 NCI:C4952 NCI:C4954 NCI:C5115 NCI:C7710 SNOMEDCT_US_2016_03_01:126952004 SNOMEDCT_US_2016_03_01:154550004 SNOMEDCT_US_2016_03_01:188279009 SNOMEDCT_US_2016_03_01:188305001 SNOMEDCT_US_2016_03_01:189537005 SNOMEDCT_US_2016_03_01:254935002 SNOMEDCT_US_2016_03_01:269610005 SNOMEDCT_US_2016_03_01:275464006 SNOMEDCT_US_2016_03_01:363356001 SNOMEDCT_US_2016_03_01:428061005 SNOMEDCT_US_2016_03_01:93727008 UMLS_CUI:C0006118 UMLS_CUI:C0153633 UMLS_CUI:C0220624 UMLS_CUI:C0750974 UMLS_CUI:C0750979 UMLS_CUI:C1334557 BT - Brain tumour adult brain tumor adult malignant brain neoplasm brain neoplasm brain neoplasm, adult malignant brain tumour malignant primary brain neoplasm malignant primary brain tumor malignant tumor of Brain malignant tumor of adult brain neoplasm of brain (disorder) neoplasm of unspecified nature of brain neoplasm of unspecified nature of brain (disorder) primary brain neoplasm primary brain tumor primary malignant neoplasm of brain (disorder) tumor of the Brain disease_ontology DOID:1319 brain cancer DOID:13207 ICD9CM:362.02 NCI:C84457 SNOMEDCT_US_2016_03_01:154679002 SNOMEDCT_US_2016_03_01:59276001 UMLS_CUI:C0154830 PDR disease_ontology DOID:13207 proliferative diabetic retinopathy DOID:13208 ICD9CM:362.01 ICD9CM:362.03 NCI:C34408 NCI:C35668 SNOMEDCT_US_2016_03_01:154680004 SNOMEDCT_US_2016_03_01:31411005 SNOMEDCT_US_2016_03_01:390718008 SNOMEDCT_US_2016_03_01:390834004 UMLS_CUI:C0004606 Non proliferative diabetic retinopathy Non-Proliferative Diabetic Retinopathy disease_ontology DOID:13208 background diabetic retinopathy DOID:13209 ICD9CM:426.51 SNOMEDCT_US_2016_03_01:46319007 UMLS_CUI:C0155704 Right bundle branch block with left posterior fascicular block (disorder) disease_ontology DOID:13209 right bundle branch block DOID:13223 A uterine benign neoplasm derived from the smooth muscle layer of the uterus. EFO:0000731 HP:0000131 ICD10CM:D25 ICD10CM:D25.9 ICD9CM:218 ICD9CM:218.9 MESH:D007889 NCI:C3434 OMIM:150699 SNOMEDCT_US_2016_03_01:146801000119103 SNOMEDCT_US_2016_03_01:154616000 SNOMEDCT_US_2016_03_01:189106003 SNOMEDCT_US_2016_03_01:44598004 SNOMEDCT_US_2016_03_01:95315005 UMLS_CUI:C0042133 Plexiform leiomyoma UTERUS FIBROMA leiomyoma of Corpus Uteri uterine leiomyoma disease_ontology DOID:13223 OMIM mapping confirmed by DO. [LS]. uterine fibroid DOID:1324 A respiratory system cancer that is located_in the lung. DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 SNOMEDCT_US_2016_03_01:187860004 SNOMEDCT_US_2016_03_01:187863002 SNOMEDCT_US_2016_03_01:187864008 SNOMEDCT_US_2016_03_01:187867001 SNOMEDCT_US_2016_03_01:187868006 SNOMEDCT_US_2016_03_01:187871003 SNOMEDCT_US_2016_03_01:187874006 SNOMEDCT_US_2016_03_01:269464000 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493 disease_ontology lung neoplasm DOID:1324 lung cancer DOID:13240 ICD10CM:K03.3 ICD9CM:521.4 MESH:D014091 SNOMEDCT_US_2016_03_01:196316003 SNOMEDCT_US_2016_03_01:70931000 UMLS_CUI:C0040451 disease_ontology DOID:13240 tooth resorption DOID:13241 A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis. EFO:0003780 ICD10CM:M35.2 ICD9CM:136.1 MESH:D001528 NCI:C34416 OMIM:109650 SNOMEDCT_US_2016_03_01:154424000 SNOMEDCT_US_2016_03_01:310701003 SNOMEDCT_US_2016_03_01:41225007 UMLS_CUI:C0004943 Adamantiades-Behcet disease Behcet syndrome Behet's syndrome triple symptom complex disease_ontology Behcet's syndrome DOID:13241 OMIM mapping confirmed by DO. [SN]. Behcet's disease DOID:1325 A respiratory system cancer that is located_in the bronchus. ICD10CM:C34 ICD10CM:C34.9 ICD9CM:162.9 SNOMEDCT_US_2016_03_01:187875007 SNOMEDCT_US_2016_03_01:190092003 SNOMEDCT_US_2016_03_01:269465004 UMLS_CUI:C0348343 malignant neoplasm of bronchus and lung, unspecified malignant neoplasm of bronchus or lung NOS (disorder) malignant neoplasm of bronchus or lung, unspecified (disorder) disease_ontology DOID:1325 bronchus cancer DOID:13250 A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea. DOID:0050006 ICD9CM:009.2 MESH:D004403 SNOMEDCT_US_2016_03_01:111939009 SNOMEDCT_US_2016_03_01:154268000 SNOMEDCT_US_2016_03_01:154279005 SNOMEDCT_US_2016_03_01:186165000 SNOMEDCT_US_2016_03_01:186167008 SNOMEDCT_US_2016_03_01:19213003 SNOMEDCT_US_2016_03_01:236076004 SNOMEDCT_US_2016_03_01:266173000 SNOMEDCT_US_2016_03_01:266180003 UMLS_CUI:C0013369 disease_ontology diarrhea of presumed infectious origin diarrhoea DOID:13250 diarrhea DOID:13268 An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins. ICD10CM:E80.20 ICD9CM:277.1 MESH:D011164 NCI:C97096 SNOMEDCT_US_2016_03_01:154768004 SNOMEDCT_US_2016_03_01:190912004 SNOMEDCT_US_2016_03_01:190916001 SNOMEDCT_US_2016_03_01:238052001 SNOMEDCT_US_2016_03_01:274090006 SNOMEDCT_US_2016_03_01:29094004 SNOMEDCT_US_2016_03_01:371628009 SNOMEDCT_US_2016_03_01:418470004 SNOMEDCT_US_2016_03_01:86292002 UMLS_CUI:C0032708 Hematoporphyria Porphyrinopathy disorder of porphyrin and hem metabolism disorder of porphyrin metabolism disease_ontology DOID:13268 porphyria DOID:13270 An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue. ICD10CM:E80.0 MESH:D046351 NCI:C84698 OMIM:177000 OMIM:300752 ORDO:79278 SNOMEDCT_US_2016_03_01:51022005 UMLS_CUI:C0162568 EPP (erythropoietic protoporphyria porphyria) Erythropoietic protoporphyria (disorder) Protoporphyria disease_ontology DOID:13270 Xref MGI. OMIM mapping confirmed by DO. [SN]. erythropoietic protoporphyria DOID:13282 A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting. ICD9CM:014.8 UMLS_CUI:C0152724 tuberculosis of intestine disease_ontology DOID:13282 intestinal tuberculosis DOID:13300 An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column. ICD10CM:M42.0 ICD10CM:M42.00 ICD9CM:732.0 MESH:D012544 NCI:C34999 OMIM:181440 SNOMEDCT_US_2016_03_01:156816000 SNOMEDCT_US_2016_03_01:203361005 SNOMEDCT_US_2016_03_01:203362003 SNOMEDCT_US_2016_03_01:203364002 SNOMEDCT_US_2016_03_01:203415006 SNOMEDCT_US_2016_03_01:53406005 UMLS_CUI:C0036310 Juvenile osteochondritis of the spine Juvenile osteochondrosis of Scheurermann Juvenile osteochondrosis of spine Scheuermann's kyphosis Sherman's Disease Scheuermann disease disease_ontology DOID:13300 OMIM mapping confirmed by DO. [SN]. Scheuermann's disease DOID:13316 MESH:D010188 NCI:C84316 SNOMEDCT_US_2016_03_01:47367009 UMLS_CUI:C0267963 Exocrine pancreatic insufficiency (disorder) disease_ontology DOID:13316 exocrine pancreatic insufficiency DOID:13317 A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin. DOID:9996 ICD10CM:E16.9 MESH:D046768 NCI:C4375 OMIM:256450 OMIM:601820 OMIM:602485 OMIM:606762 OMIM:609968 OMIM:609975 OMIM:610021 SNOMEDCT_US_2016_03_01:190450004 SNOMEDCT_US_2016_03_01:237649006 SNOMEDCT_US_2016_03_01:360337007 SNOMEDCT_US_2016_03_01:42681006 SNOMEDCT_US_2016_03_01:66149005 UMLS_CUI:C0027773 Islet cell hyperplasia nesidioblastosis persistent hyperinsulinemia hypoglycemia of infancy disease_ontology DOID:13317 OMIM mapping confirmed by DO. [SN]. hyperinsulinemic hypoglycemia DOID:13328 ICD9CM:366.41 SNOMEDCT_US_2016_03_01:154678005 SNOMEDCT_US_2016_03_01:155129005 SNOMEDCT_US_2016_03_01:267471001 SNOMEDCT_US_2016_03_01:267722005 SNOMEDCT_US_2016_03_01:43959009 UMLS_CUI:C0011876 Cataract - diabetic disease_ontology DOID:13328 diabetic cataract DOID:13372 A plasma protein metabolism disease that has_material_basis_in defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells. ICD10CM:E88.01 ICD9CM:273.4 MESH:D019896 NCI:C84397 OMIM:613490 SNOMEDCT_US_2016_03_01:154771007 SNOMEDCT_US_2016_03_01:30188007 UMLS_CUI:C0221757 AAT deficiency disease_ontology DOID:13372 OMIM mapping confirmed by DO. [SN]. alpha 1-antitrypsin deficiency DOID:13374 .A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene. ICD10CM:M61.1 ICD10CM:M61.10 ICD9CM:728.11 MESH:D009221 NCI:C3040 OMIM:135100 SNOMEDCT_US_2016_03_01:205527009 SNOMEDCT_US_2016_03_01:240121004 SNOMEDCT_US_2016_03_01:82725007 UMLS_CUI:C0016037 Stone Man Syndrome myositis ossificans progressiva progressive myositis ossificans progressive ossifying myositis disease_ontology DOID:13374 OMIM mapping confirmed by DO. [SN]. fibrodysplasia ossificans progressiva DOID:13378 A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities. EFO:0004246 ICD10CM:M30.3 ICD9CM:446.1 MESH:D009080 NCI:C34825 OMIM:611775 SNOMEDCT_US_2016_03_01:155444003 SNOMEDCT_US_2016_03_01:195348009 SNOMEDCT_US_2016_03_01:195349001 SNOMEDCT_US_2016_03_01:75053002 UMLS_CUI:C0026691 Kawasaki's disease MLNS acute febrile MCLS acute febrile mucocutaneous lymph node syndrome [MCLS] mucocutaneous lymph node syndrome disease_ontology DOID:13378 OMIM mapping confirmed by DO. [SN]. Kawasaki disease DOID:1338 A congenital hemolytic anemia characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood. ICD10CM:D64.4 MESH:D000742 NCI:C84646 OMIM:105600 OMIM:224100 OMIM:224120 OMIM:613673 OMIM:615631 ORDO:85 SNOMEDCT_US_2016_03_01:191272005 SNOMEDCT_US_2016_03_01:52951008 UMLS_CUI:C0002876 congenital dyshaematopoietic anaemia disease_ontology DOID:1338 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital dyserythropoietic anemia DOID:1339 A congenital hypoplastic anemia that is characterized by anemia (low red blood cell counts) with decreased erythroid progenitors in the bone marrow and has_material_basis insufficient levels of red blood cells due to bone marrow dysfunction. ICD10CM:D61.01 MESH:D029503 NCI:C61236 OMIM:105650 OMIM:606129 OMIM:610629 OMIM:612527 OMIM:612528 OMIM:612561 OMIM:612562 OMIM:612563 OMIM:613308 OMIM:613309 OMIM:614900 OMIM:615550 OMIM:615909 ORDO:124 SNOMEDCT_US_2016_03_01:188588001 SNOMEDCT_US_2016_03_01:191235004 SNOMEDCT_US_2016_03_01:191239005 SNOMEDCT_US_2016_03_01:234371002 SNOMEDCT_US_2016_03_01:88854002 UMLS_CUI:C1260899 Blackfan - Diamond syndrome chronic constitutional pure red cell anaemia disease_ontology DOID:1339 Xref MGI. OMIM mapping confirmed by DO. [SN]. Diamond-Blackfan anemia DOID:13399 A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions. ICD10CM:H53.5 ICD10CM:H53.50 ICD9CM:368.5 MESH:D003117 NCI:C3891 SNOMEDCT_US_2016_03_01:155143000 SNOMEDCT_US_2016_03_01:193683001 SNOMEDCT_US_2016_03_01:193685008 SNOMEDCT_US_2016_03_01:53481002 UMLS_CUI:C0242225 BLINDNESS COLOR Colour blindness Colour vision deficiency disease_ontology DOID:13399 color blindness DOID:13413 A brain disease that is characterized by loss of brain function, the occurrence of confusion, altered level of consciousness, and coma that results when the liver is unable to remove toxins from the blood. ICD10CM:K72 ICD9CM:572.2 MESH:D006501 NCI:C79596 SNOMEDCT_US_2016_03_01:123049003 SNOMEDCT_US_2016_03_01:13920009 SNOMEDCT_US_2016_03_01:197332007 SNOMEDCT_US_2016_03_01:449902003 UMLS_CUI:C0019151 Portal-systemic encephalopathy disease_ontology DOID:13413 hepatic encephalopathy DOID:1342 DOID:13639 ICD10CM:D61.0 ICD10CM:D61.01 ICD9CM:284.0 MESH:D029502 SNOMEDCT_US_2016_03_01:154808006 SNOMEDCT_US_2016_03_01:188588001 SNOMEDCT_US_2016_03_01:191235004 SNOMEDCT_US_2016_03_01:191236003 SNOMEDCT_US_2016_03_01:191242004 SNOMEDCT_US_2016_03_01:267523003 SNOMEDCT_US_2016_03_01:28975000 SNOMEDCT_US_2016_03_01:88854002 UMLS_CUI:C0702159 UMLS_CUI:C0949116 congenital aplastic anemia disease_ontology Constitutional aplastic anaemia DOID:1342 congenital hypoplastic anemia DOID:13476 ICD10CM:C32.1 ICD9CM:161.1 NCI:C3545 SNOMEDCT_US_2016_03_01:154482003 SNOMEDCT_US_2016_03_01:187842004 SNOMEDCT_US_2016_03_01:269558005 SNOMEDCT_US_2016_03_01:94080006 UMLS_CUI:C0153484 Ca larynx - supraglottis Ca larynx - supraglottis (disorder) malignant Supraglottic tumor malignant neoplasm of extrinsic larynx malignant neoplasm of supraglottis malignant tumor of supraglottis (disorder) supraglottis disease_ontology DOID:13476 supraglottis cancer DOID:13481 An osteochondrodysplasia that results_in short arms and legs with excess folds of skin. ICD10CM:Q77.1 MESH:D013796 NCI:C85187 OMIM:187600 OMIM:187601 OMIM:273680 ORDO:1860 ORDO:2655 ORDO:93274 ORDO:93275 SNOMEDCT_US_2016_03_01:29352008 UMLS_CUI:C0039743 disease_ontology DOID:13481 Xref MGI. OMIM mapping confirmed by DO. [LS]. thanatophoric dysplasia DOID:13482 MESH:D016715 NCI:C85032 OMIM:176920 SNOMEDCT_US_2016_03_01:23150001 SNOMEDCT_US_2016_03_01:394527003 UMLS_CUI:C0085261 Wiedemann's syndrome disease_ontology DOID:13482 OMIM mapping confirmed by DO. [SN]. Proteus syndrome DOID:13487 A pervasive developmental disorder that is a rare condition characterized by late onset (>3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress. ICD10CM:F84.3 ICD9CM:299.1 NCI:C97164 SNOMEDCT_US_2016_03_01:191694008 SNOMEDCT_US_2016_03_01:192584009 SNOMEDCT_US_2016_03_01:71961003 UMLS_CUI:C0236791 Disintegrative psychosis NOS (disorder) Heller's syndrome Symbiotic psychosis disease_ontology DOID:13487 childhood disintegrative disease DOID:13515 ICD10CM:Q85.1 ICD9CM:759.5 MESH:D014402 NCI:C3424 OMIM:191100 OMIM:613254 SNOMEDCT_US_2016_03_01:157027006 SNOMEDCT_US_2016_03_01:157033002 SNOMEDCT_US_2016_03_01:268359006 SNOMEDCT_US_2016_03_01:7199000 UMLS_CUI:C0041341 Bourneville's disease Epiloia Tuberose sclerosis Tuberous sclerosis Tuberous sclerosis syndrome (disorder) cerebral sclerosis disease_ontology DOID:13515 OMIM mapping confirmed by DO. [LS]. tuberous sclerosis DOID:1352 MESH:D010254 NCI:C26843 SNOMEDCT_US_2016_03_01:195823002 SNOMEDCT_US_2016_03_01:7393007 UMLS_CUI:C0030469 disorder of nasal sinus disease_ontology DOID:1352 paranasal sinus disease DOID:13521 A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has_symptom stiff body, has_symptom muscle spasms, has_symptom difficulty in breathing, and has_symptom exhaustion. ICD10CM:A33 ICD9CM:771.3 NCI:C116814 SNOMEDCT_US_2016_03_01:206338004 SNOMEDCT_US_2016_03_01:206339007 SNOMEDCT_US_2016_03_01:43424001 UMLS_CUI:C0343312 Tetanus neonatorum (disorder) neonatal tetanus disease_ontology DOID:13521 tetanus neonatorum DOID:13533 An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones. ICD10CM:Q78.2 ICD9CM:756.52 MESH:D010022 NCI:C26840 OMIM:166600 OMIM:259700 OMIM:259710 OMIM:259720 OMIM:259730 OMIM:607634 OMIM:611490 OMIM:611497 OMIM:612301 OMIM:615085 ORDO:667 SNOMEDCT_US_2016_03_01:1926006 SNOMEDCT_US_2016_03_01:205500005 SNOMEDCT_US_2016_03_01:205502002 SNOMEDCT_US_2016_03_01:360504006 SNOMEDCT_US_2016_03_01:367489004 SNOMEDCT_US_2016_03_01:63941000 UMLS_CUI:C0029454 Albers-Schonberg disease marble bone disease_ontology DOID:13533 Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS]. osteopetrosis DOID:13543 A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body. ICD10CM:E21.3 ICD9CM:252.0 ICD9CM:252.00 MESH:D006961 NCI:C48259 OMIM:145000 OMIM:145001 OMIM:610071 ORDO:99879 SNOMEDCT_US_2016_03_01:154696001 SNOMEDCT_US_2016_03_01:190451000 SNOMEDCT_US_2016_03_01:66999008 UMLS_CUI:C0020502 disease_ontology DOID:13543 Xref MGI. hyperparathyroidism DOID:13544 ICD10CM:H40.12 ICD9CM:365.12 MESH:D057066 SNOMEDCT_US_2016_03_01:155124000 SNOMEDCT_US_2016_03_01:193567005 SNOMEDCT_US_2016_03_01:50485007 UMLS_CUI:C0152136 Normal tension glaucoma disease_ontology DOID:13544 low tension glaucoma DOID:13550 MESH:D015812 NCI:C34639 SNOMEDCT_US_2016_03_01:193544008 SNOMEDCT_US_2016_03_01:270882001 SNOMEDCT_US_2016_03_01:33647009 SNOMEDCT_US_2016_03_01:392291006 UMLS_CUI:C0017605 ACG - Angle-closure glaucoma Angle Closure Glaucoma Angle-closure glaucoma (disorder) Closed angle glaucoma Narrow cleft glaucoma primary open-angle glaucoma with narrow angles disease_ontology DOID:13550 angle-closure glaucoma DOID:13564 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system. CSP:1988-4002 ICD10CM:B44 ICD10CM:B44.9 ICD9CM:117.3 MESH:D001228 NCI:C2886 SNOMEDCT_US_2016_03_01:154408001 SNOMEDCT_US_2016_03_01:187087004 SNOMEDCT_US_2016_03_01:187492008 SNOMEDCT_US_2016_03_01:266218008 SNOMEDCT_US_2016_03_01:65553006 UMLS_CUI:C0004030 Infection due to Aspergillus disease_ontology DOID:13564 aspergillosis DOID:13580 ICD10CM:K83.1 ICD9CM:576.2 MESH:D002779 NCI:C83006 SNOMEDCT_US_2016_03_01:197446008 SNOMEDCT_US_2016_03_01:197447004 SNOMEDCT_US_2016_03_01:30144000 SNOMEDCT_US_2016_03_01:33688009 UMLS_CUI:C0008370 Obstruction of bile duct bile occlusion disease_ontology DOID:13580 cholestasis DOID:1360 ICD10CM:C31.2 ICD9CM:160.4 NCI:C3542 SNOMEDCT_US_2016_03_01:363427000 SNOMEDCT_US_2016_03_01:93808006 UMLS_CUI:C0153478 malignant neoplasm of frontal sinus malignant tumor of frontal sinus (disorder) malignant tumor of the Frontal sinus disease_ontology DOID:1360 frontal sinus cancer DOID:13622 A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever. DOID:13621 MESH:D002169 SNOMEDCT_US_2016_03_01:86500004 UMLS_CUI:C0006818 (Campylobacter GIT infection (& [diarrhea] or [enteritis]) or (helicobacter gastritis) Campylobacteriosis (disorder) disease_ontology DOID:13622 campylobacteriosis DOID:13628 A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans. ICD10CM:D55.0 MESH:D005236 NCI:C34607 SNOMEDCT_US_2016_03_01:154801000 SNOMEDCT_US_2016_03_01:191172001 SNOMEDCT_US_2016_03_01:267558001 SNOMEDCT_US_2016_03_01:76500009 UMLS_CUI:C0015702 DOID:13628 favism DOID:13636 A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair. ICD10CM:D61.09 MESH:D005199 NCI:C62505 OMIM:227645 OMIM:227646 OMIM:227650 OMIM:300514 OMIM:600901 OMIM:603467 OMIM:605724 OMIM:609053 OMIM:609054 OMIM:610832 OMIM:613390 OMIM:613951 OMIM:614082 OMIM:614083 OMIM:615272 OMIM:616435 OMIM:617243 OMIM:617244 OMIM:617247 ORDO:84 SNOMEDCT_US_2016_03_01:30575002 UMLS_CUI:C0015625 Fanconi pancytopenia Fanconi panmyelopathy Fanconi's anemia disease_ontology DOID:13636 Xref MGI. OMIM mapping confirmed by DO. [SN]. OMIM mapping by NeuroDevNet. [LS]. Fanconi anemia DOID:13709 ICD10CM:F52.4 ICD9CM:302.75 MESH:D061686 NCI:C94349 SNOMEDCT_US_2016_03_01:123302009 SNOMEDCT_US_2016_03_01:154905005 SNOMEDCT_US_2016_03_01:192468006 SNOMEDCT_US_2016_03_01:268762007 SNOMEDCT_US_2016_03_01:44001008 UMLS_CUI:C0033038 disease_ontology DOID:13709 premature ejaculation DOID:13725 ICD10CM:E51.1 ICD10CM:E51.11 ICD9CM:265.0 MESH:D001602 NCI:C34418 SNOMEDCT_US_2016_03_01:154725000 SNOMEDCT_US_2016_03_01:190625009 SNOMEDCT_US_2016_03_01:267491008 SNOMEDCT_US_2016_03_01:35843007 SNOMEDCT_US_2016_03_01:36656008 UMLS_CUI:C0005122 disease_ontology DOID:13725 beriberi DOID:1373 NCI:C4262 SNOMEDCT_US_2016_03_01:189810002 SNOMEDCT_US_2016_03_01:70971005 UMLS_CUI:C0334485 disease_ontology DOID:1373 endometrial stromal nodule DOID:13774 An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands. ICD10CM:E27.1 MESH:D000224 NCI:C26689 OMIM:103230 OMIM:240200 SNOMEDCT_US_2016_03_01:111562000 SNOMEDCT_US_2016_03_01:154707007 SNOMEDCT_US_2016_03_01:267483004 SNOMEDCT_US_2016_03_01:363732003 SNOMEDCT_US_2016_03_01:367376006 SNOMEDCT_US_2016_03_01:373662000 SNOMEDCT_US_2016_03_01:68588005 UMLS_CUI:C0001403 Addison disease Addison disease, chronic adrenal insufficiency HYPOADRENOCORTICISM, FAMILIAL primary adrenocortical insufficiency primary hypoadrenalism disease_ontology DOID:13774 Addison's disease DOID:13777 An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body. MESH:D004819 OMIM:226400 SNOMEDCT_US_2016_03_01:19138001 UMLS_CUI:C0014522 disease_ontology DOID:13777 OMIM mapping confirmed by DO. [SN]. epidermodysplasia verruciformis DOID:13781 ICD10CM:M35.7 ICD9CM:728.5 SNOMEDCT_US_2016_03_01:156723005 SNOMEDCT_US_2016_03_01:85551004 UMLS_CUI:C0152093 benign joint hypermobility hypermobility syndrome (disorder) disease_ontology DOID:13781 hypermobility syndrome DOID:1380 A uterine cancer that is located_in tissues lining the uterus. DOID:5654 EFO:0004230 ICD10CM:C54.1 KEGG:05213 MESH:D016889 NCI:C27815 NCI:C3012 OMIM:608089 SNOMEDCT_US_2016_03_01:123844007 UMLS_CUI:C0007103 UMLS_CUI:C0014170 endometrial Ca endometrial neoplasm malignant endometrial neoplasm malignant neoplasm of endometrium neoplasm of endometrium (disorder) primary malignant neoplasm of endometrium tumor of Endometrium disease_ontology DOID:1380 endometrial cancer DOID:13809 ICD10CM:E78.4 MESH:D006950 OMIM:144250 SNOMEDCT_US_2016_03_01:154742006 SNOMEDCT_US_2016_03_01:190780005 SNOMEDCT_US_2016_03_01:238040008 SNOMEDCT_US_2016_03_01:299465007 SNOMEDCT_US_2016_03_01:48190005 UMLS_CUI:C0020474 familial combined hyperlipidemia (disorder) familial combined hyperlipidemia (disorder) [Ambiguous] familial multiple lipoprotein-type hyperlipidemia (disorder) hyperbetalipoproteinemia with prebetalipoproteinemia mixed hyperlipidaemia mixed hyperlipidemia mixed hyperlipidemia (disorder) type IIb hyperlipoproteinemia disease_ontology DOID:13809 OMIM mapping confirmed by DO. [SN]. familial combined hyperlipidemia DOID:13812 SNOMEDCT_US_2016_03_01:301789000 SNOMEDCT_US_2016_03_01:31107007 SNOMEDCT_US_2016_03_01:361115000 SNOMEDCT_US_2016_03_01:367435001 UMLS_CUI:C0241593 Band of uterus Intrauterine adhesions Intrauterine synechiae disease_ontology DOID:13812 adhesions of uterus DOID:1382 ICD10CM:L74.3 MESH:D008883 NCI:C34820 SNOMEDCT_US_2016_03_01:201196009 SNOMEDCT_US_2016_03_01:201411009 SNOMEDCT_US_2016_03_01:63951004 UMLS_CUI:C0026113 disease_ontology DOID:1382 miliaria DOID:1383 ICD10CM:L74 ICD10CM:L74.9 ICD9CM:705 ICD9CM:705.9 MESH:D013543 SNOMEDCT_US_2016_03_01:156413000 SNOMEDCT_US_2016_03_01:201209003 SNOMEDCT_US_2016_03_01:88232005 UMLS_CUI:C0038986 disease_ontology DOID:1383 sweat gland disease DOID:13832 ICD10CM:Q25.0 ICD9CM:747.0 MESH:D004374 NCI:C84492 OMIM:607411 SNOMEDCT_US_2016_03_01:156928009 SNOMEDCT_US_2016_03_01:83330001 UMLS_CUI:C0013274 Patent ductus Botalli disease_ontology ductus arteriosus, Patent DOID:13832 OMIM mapping confirmed by DO. [SN]. patent ductus arteriosus DOID:13868 ICD10CM:F52.0 ICD9CM:302.71 MESH:D020018 NCI:C94337 SNOMEDCT_US_2016_03_01:112096004 SNOMEDCT_US_2016_03_01:192464008 SNOMEDCT_US_2016_03_01:270903007 SNOMEDCT_US_2016_03_01:78889008 UMLS_CUI:C0020594 Lack or loss of sexual desire disease_ontology DOID:13868 hypoactive sexual desire disorder DOID:13884 ICD10CM:I49.5 MESH:D012804 NCI:C62244 OMIM:163800 OMIM:608567 OMIM:614090 ORDO:166282 SNOMEDCT_US_2016_03_01:155373001 SNOMEDCT_US_2016_03_01:266307005 SNOMEDCT_US_2016_03_01:36083008 UMLS_CUI:C0037052 sinus node infection disease_ontology DOID:13884 Xref MGI. sick sinus syndrome DOID:1389 A peripheral system disease that is characterized by is damage affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, pins-and-needles, and burning pain. ICD10CM:A69.22 ICD10CM:G62.9 MESH:D011115 NCI:C26951 SNOMEDCT_US_2016_03_01:155080009 SNOMEDCT_US_2016_03_01:193166009 SNOMEDCT_US_2016_03_01:193204000 SNOMEDCT_US_2016_03_01:194530007 SNOMEDCT_US_2016_03_01:267706009 SNOMEDCT_US_2016_03_01:307326004 SNOMEDCT_US_2016_03_01:42345000 UMLS_CUI:C0152025 disease_ontology DOID:1389 polyneuropathy DOID:13910 ICD10CM:H53.54 ICD9CM:368.51 MESH:D003117 OMIM:303900 SNOMEDCT_US_2016_03_01:51445007 UMLS_CUI:C0155015 Protan defect Protanopia disease_ontology DOID:13910 red color blindness DOID:13911 A color blindness that is characterized by a congenital cone color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels has_material_basis_in autosomal recessive inheritance. ICD10CM:H53.51 ICD9CM:368.54 MESH:D003117 NCI:C84528 ORDO:49382 SNOMEDCT_US_2016_03_01:56852002 UMLS_CUI:C0152200 ACHM Monochromatism disease_ontology DOID:13911 achromatopsia DOID:13922 An esophagitis characterized by inflammation involving eosinophils located_in esophagus. EFO:0004232 ICD10CM:K20.0 ICD9CM:530.13 MESH:D057765 NCI:C27105 OMIM:610247 OMIM:613412 ORDO:73247 SNOMEDCT_US_2016_03_01:235599003 UMLS_CUI:C0341106 disease_ontology DOID:13922 Xref MGI. OMIM mapping confirmed by DO. [SN]. eosinophilic esophagitis DOID:13934 ICD10CM:G51.0 MESH:D005158 NCI:C26769 SNOMEDCT_US_2016_03_01:155070005 SNOMEDCT_US_2016_03_01:267703001 SNOMEDCT_US_2016_03_01:280816001 SNOMEDCT_US_2016_03_01:46382007 SNOMEDCT_US_2016_03_01:79359001 SNOMEDCT_US_2016_03_01:90039006 UMLS_CUI:C0015469 Facial Palsy disease_ontology DOID:13934 facial paralysis DOID:13938 ICD10CM:N91.2 ICD9CM:626.0 MESH:D000568 NCI:C61443 SNOMEDCT_US_2016_03_01:14302001 SNOMEDCT_US_2016_03_01:156034000 SNOMEDCT_US_2016_03_01:156037007 SNOMEDCT_US_2016_03_01:198414005 UMLS_CUI:C0002453 absence of menstruation amenia disease_ontology DOID:13938 amenorrhea DOID:13941 ICD9CM:386.11 MESH:D065635 OMIM:193007 OMIM:613106 SNOMEDCT_US_2016_03_01:111541001 SNOMEDCT_US_2016_03_01:232285008 SNOMEDCT_US_2016_03_01:267763004 UMLS_CUI:C0155502 benign paroxysmal positional vertigo disease_ontology DOID:13941 Xref MGI. OMIM mapping confirmed by DO. [SN]. benign paroxysmal positional nystagmus DOID:13949 MESH:D018856 NCI:C27189 SNOMEDCT_US_2016_03_01:111409009 SNOMEDCT_US_2016_03_01:197834003 UMLS_CUI:C0282488 ulcerative cystitis disease_ontology DOID:13949 interstitial cystitis DOID:1395 A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria. ICD9CM:120.8 SNOMEDCT_US_2016_03_01:187116001 SNOMEDCT_US_2016_03_01:187121003 UMLS_CUI:C0029827 disease_ontology DOID:1395 schistosomiasis DOID:13976 ICD9CM:530.11 MESH:D004942 SNOMEDCT_US_2016_03_01:155673008 SNOMEDCT_US_2016_03_01:196600005 SNOMEDCT_US_2016_03_01:266498005 SNOMEDCT_US_2016_03_01:54856001 SNOMEDCT_US_2016_03_01:57643001 UMLS_CUI:C0014869 Peptic esophagitis Peptic reflux disease Reflux oesophagitis reflux esophagitis disease_ontology DOID:13976 peptic esophagitis DOID:1398 A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host. DOID:11681 DOID:13509 DOID:1396 DOID:1494 DOID:2114 DOID:2293 DOID:2922 DOID:3564 DOID:4191 DOID:886 DOID:948 DOID:9639 DOID:9644 ICD10CM:H44.12 ICD9CM:360.13 NCI:C34587 SNOMEDCT_US_2016_03_01:193273005 SNOMEDCT_US_2016_03_01:57100005 UMLS_CUI:C0014238 Ectoparasitic disease parasitemia disease_ontology DOID:1398 parasitic infectious disease DOID:1400 ICD10CM:H04 ICD10CM:H04.9 ICD9CM:375 ICD9CM:375.9 MESH:D007766 NCI:C26809 SNOMEDCT_US_2016_03_01:155181005 SNOMEDCT_US_2016_03_01:155185001 SNOMEDCT_US_2016_03_01:194003009 SNOMEDCT_US_2016_03_01:267740009 SNOMEDCT_US_2016_03_01:31053003 UMLS_CUI:C0022904 disease_ontology DOID:1400 lacrimal apparatus disease DOID:14004 An aortic aneurysm that is located_in the thoracic aorta. EFO:0004282 MESH:D017545 NCI:C27001 OMIM:132900 OMIM:607086 OMIM:607087 OMIM:611788 OMIM:613780 OMIM:615436 ORDO:91387 SNOMEDCT_US_2016_03_01:155421001 SNOMEDCT_US_2016_03_01:433068007 UMLS_CUI:C0162872 disease_ontology DOID:14004 Xref MGI. OMIM mapping confirmed by DO. [SN]. thoracic aortic aneurysm DOID:14018 CSP:1754-7677 ICD10CM:K70.3 ICD9CM:571.2 MESH:D008104 NCI:C34782 SNOMEDCT_US_2016_03_01:155811002 SNOMEDCT_US_2016_03_01:197280008 SNOMEDCT_US_2016_03_01:235894003 SNOMEDCT_US_2016_03_01:266467008 SNOMEDCT_US_2016_03_01:420054005 SNOMEDCT_US_2016_03_01:75393009 UMLS_CUI:C0023891 Alcoholic Cirrhosis Alcoholic cirrhosis of liver Laennec's cirrhosis Laennec's cirrhosis, alcoholic Portal cirrhosis disease_ontology DOID:14018 alcoholic liver cirrhosis DOID:14040 An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. ICD10CM:E31.0 MESH:D016884 NCI:C84576 SNOMEDCT_US_2016_03_01:18947001 SNOMEDCT_US_2016_03_01:190567009 SNOMEDCT_US_2016_03_01:190568004 SNOMEDCT_US_2016_03_01:41864002 UMLS_CUI:C0085409 Autoimmune polyglandular failure Lloyd's syndrome autoimmune polyendocrinopathy disease_ontology DOID:14040 autoimmune polyendocrine syndrome DOID:14042 A bipolar disorder that is characterized by at least one manic or mixed episode. ICD9CM:296.50 SNOMEDCT_US_2016_03_01:49468007 UMLS_CUI:C0236773 disease_ontology DOID:14042 bipolar I disorder DOID:1405 ICD10CM:H40.2 ICD10CM:H40.20 ICD9CM:365.2 ICD9CM:365.20 NCI:C34640 SNOMEDCT_US_2016_03_01:155123006 SNOMEDCT_US_2016_03_01:193544008 SNOMEDCT_US_2016_03_01:193545009 SNOMEDCT_US_2016_03_01:193547001 SNOMEDCT_US_2016_03_01:270882001 SNOMEDCT_US_2016_03_01:392288006 SNOMEDCT_US_2016_03_01:42456004 UMLS_CUI:C0017606 primary Angle Closure Glaucoma disease_ontology DOID:1405 primary angle-closure glaucoma DOID:14087 A bone inflammation disease that results_in inflammation located_in epicondyle. DOID:14162 ICD10CM:M77.1 ICD9CM:726.32 MESH:D013716 NCI:C34589 NCI:C35067 SNOMEDCT_US_2016_03_01:156659008 SNOMEDCT_US_2016_03_01:202855006 SNOMEDCT_US_2016_03_01:24133009 SNOMEDCT_US_2016_03_01:268088003 SNOMEDCT_US_2016_03_01:73583000 UMLS_CUI:C0014488 UMLS_CUI:C0039516 Lateral epicondylitis andrel epicondylitis archer's elbow golfer's elbow hockey elbow medial epicondylitis disease_ontology shooter's elbow tennis elbow DOID:14087 epicondylitis DOID:14089 ICD9CM:521.08 MESH:D017213 SNOMEDCT_US_2016_03_01:234975001 SNOMEDCT_US_2016_03_01:30512007 UMLS_CUI:C0162644 Cementum caries Dental caries of root surface Root caries disease_ontology DOID:14089 root caries DOID:14115 A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities. ICD10CM:A48.3 ICD9CM:040.82 MESH:D012772 NCI:C35498 SNOMEDCT_US_2016_03_01:18504008 UMLS_CUI:C0600327 TSS Toxic Shock syndrome Toxic shock syndrome Toxic shock syndrome (disorder) toxic shock disease_ontology DOID:14115 toxic shock syndrome DOID:1412 A urinary system disease which consists of the presence of bacteria in urine. CSP:3045-9976 HP:0012461 MESH:D001437 MedDRA:10004056 SNOMEDCT_US_2016_03_01:61373006 UMLS_CUI:C0004659 disease_ontology DOID:1412 bacteriuria DOID:1414 ICD9CM:256.3 ICD9CM:256.39 SNOMEDCT_US_2016_03_01:190543001 SNOMEDCT_US_2016_03_01:190548005 SNOMEDCT_US_2016_03_01:267399006 UMLS_CUI:C0029697 disease_ontology DOID:1414 ovarian dysfunction DOID:14146 ICD9CM:592.1 MESH:D053039 NCI:C114696 SNOMEDCT_US_2016_03_01:31054009 SNOMEDCT_US_2016_03_01:95573009 UMLS_CUI:C0041952 Ureteric calculus Ureteric stone calculus of ureter disease_ontology DOID:14146 ureterolithiasis DOID:14174 MESH:D018306 NCI:C3791 SNOMEDCT_US_2016_03_01:128858006 SNOMEDCT_US_2016_03_01:302832007 UMLS_CUI:C0206719 Neurolipocytoma disease_ontology DOID:14174 central neurocytoma DOID:14177 ICD9CM:279.04 SNOMEDCT_US_2016_03_01:190983003 SNOMEDCT_US_2016_03_01:267460002 UMLS_CUI:C1457897 Congenital hypogammaglobulinaemia Congenital hypogammaglobulinemia (finding) disease_ontology DOID:14177 congenital hypogammaglobulinemia DOID:14188 ICD10CM:M75.0 ICD9CM:726.0 MESH:D002062 SNOMEDCT_US_2016_03_01:156658000 SNOMEDCT_US_2016_03_01:156664007 SNOMEDCT_US_2016_03_01:202837002 SNOMEDCT_US_2016_03_01:202847004 SNOMEDCT_US_2016_03_01:268087008 SNOMEDCT_US_2016_03_01:399114005 SNOMEDCT_US_2016_03_01:8753005 UMLS_CUI:C0311223 Adhesive capsulitis of shoulder adhesions-capsulitis,shoulder disease_ontology DOID:14188 frozen shoulder DOID:14219 A renal tubular transport disease characterized by excess levels of acid in the blood, due to a failure of the kidneys to appropriately acidify the urine. ICD10CM:N25.89 MESH:D000141 NCI:C28129 OMIM:179830 OMIM:267200 OMIM:602722 SNOMEDCT_US_2016_03_01:1776003 UMLS_CUI:C0001126 disease_ontology DOID:14219 Xref MGI. renal tubular acidosis DOID:14221 EFO:0000195 ICD10CM:E88.81 ICD9CM:277.7 MESH:D024821 NCI:C84442 OMIM:605552 SNOMEDCT_US_2016_03_01:190394009 SNOMEDCT_US_2016_03_01:237602007 UMLS_CUI:C0524620 abdominal obesity-metabolic syndrome 1 dysmetabolic syndrome X disease_ontology DOID:14221 OMIM mapping confirmed by DO. [SN]. metabolic syndrome X DOID:14227 A male infertility disease characterized by the absence of any measurable level of sperm in semen. EFO:0000279 ICD10CM:N46.0 ICD10CM:N46.01 ICD9CM:606.0 MESH:D053713 NCI:C80076 OMIM:102530 OMIM:108420 OMIM:243060 OMIM:258150 OMIM:270960 OMIM:309120 OMIM:415000 OMIM:606766 OMIM:612997 OMIM:613957 OMIM:613958 OMIM:614822 OMIM:615081 OMIM:615413 OMIM:615841 OMIM:615842 ORDO:217034 SNOMEDCT_US_2016_03_01:145008007 SNOMEDCT_US_2016_03_01:155925000 SNOMEDCT_US_2016_03_01:167781002 SNOMEDCT_US_2016_03_01:198010009 SNOMEDCT_US_2016_03_01:425558002 SNOMEDCT_US_2016_03_01:48188009 UMLS_CUI:C0004509 spermatogenic failure disease_ontology DOID:14227 Xref MGI. azoospermia DOID:14228 ICD10CM:N46.1 ICD10CM:N46.11 ICD9CM:606.1 MESH:D009845 NCI:C34860 UMLS_CUI:C0028960 disease_ontology DOID:14228 oligospermia DOID:14247 A suppurative otitis media which is persistent and long-lasting. ICD10CM:H66.3 ICD9CM:382.3 SNOMEDCT_US_2016_03_01:155228005 SNOMEDCT_US_2016_03_01:194284006 SNOMEDCT_US_2016_03_01:232253005 SNOMEDCT_US_2016_03_01:38394007 UMLS_CUI:C0271454 chronic suppurative otitis media disease_ontology DOID:14247 chronic purulent otitis media DOID:14250 A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability. ICD10CM:Q90 ICD10CM:Q90.9 ICD9CM:758.0 MESH:D004314 NCI:C101222 NCI:C2993 OMIM:190685 SNOMEDCT_US_2016_03_01:157019002 SNOMEDCT_US_2016_03_01:205614001 SNOMEDCT_US_2016_03_01:205618003 SNOMEDCT_US_2016_03_01:254263008 SNOMEDCT_US_2016_03_01:41040004 UMLS_CUI:C0013080 Complete trisomy 21 syndrome (disorder) Down's syndrome Down's syndrome - trisomy 21 Downs syndrome G Trisomy trisomy 21 syndrome disease_ontology DOID:14250 OMIM mapping confirmed by DO. [SN]. Down syndrome DOID:14256 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain. ICD10CM:M06.1 MESH:D016706 SNOMEDCT_US_2016_03_01:201449008 SNOMEDCT_US_2016_03_01:201815006 SNOMEDCT_US_2016_03_01:239920006 UMLS_CUI:C0085253 adult onset Still's disease adult-onset Still disease disease_ontology DOID:14256 adult-onset Still's disease DOID:1426 A urinary system disease that is located_in the ureter. MESH:D014515 NCI:C27148 UMLS_CUI:C0041954 disease_ontology DOID:1426 ureteral disease DOID:14261 An X-linked disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in X-linked inheritance and a loss of FMR1 function. ICD10CM:Q99.2 ICD9CM:759.83 MESH:D005600 NCI:C84717 OMIM:300624 SNOMEDCT_US_2016_03_01:390007001 SNOMEDCT_US_2016_03_01:613003 UMLS_CUI:C0016667 FRAGILE X MENTAL RETARDATION SYNDROME MARKER X SYNDROME MARTIN-BELL SYNDROME disease_ontology DOID:14261 OMIM mapping confirmed by DO. [SN]. fragile X syndrome DOID:14264 A neonatal period electroclinical syndrome that is characterized by tonic-clonic seizures in newborns occurring within the first seven days of life and ceasing within the first 15 weeks of life and has_material_basis_in autosomal dominant inheritance of voltage-gated potassium channels or a chromosomal inversion. MESH:D020936 NCI:C84593 OMIM:121200 OMIM:121201 OMIM:269720 ORDO:1949 SNOMEDCT_US_2016_03_01:276724002 SNOMEDCT_US_2016_03_01:38281008 UMLS_CUI:C0270851 benign familial neonatal seizures benign neonatal convulsions disease_ontology DOID:14264 Xref MGI. benign neonatal seizures DOID:14268 EFO:0004268 ICD10CM:K83.0 MESH:D015209 SNOMEDCT_US_2016_03_01:197443000 SNOMEDCT_US_2016_03_01:235917005 SNOMEDCT_US_2016_03_01:4032000 UMLS_CUI:C0008313 fibrosing cholangitis disease_ontology DOID:14268 sclerosing cholangitis DOID:14270 ICD10CM:K83.0 NCI:C35372 SNOMEDCT_US_2016_03_01:26918003 UMLS_CUI:C0311273 Ascending Cholangitis Ascending cholangitis (disorder) disease_ontology DOID:14270 ascending cholangitis DOID:1428 ICD10CM:E16 ICD9CM:251 SNOMEDCT_US_2016_03_01:190427005 SNOMEDCT_US_2016_03_01:190450004 SNOMEDCT_US_2016_03_01:237574003 SNOMEDCT_US_2016_03_01:267385007 UMLS_CUI:C0154189 disease_ontology DOID:1428 endocrine pancreas disease DOID:14284 MESH:D046788 UMLS_CUI:C0877149 disease_ontology DOID:14284 patellofemoral pain syndrome DOID:14291 MESH:D044542 NCI:C84820 OMIM:151100 OMIM:611554 OMIM:613707 SNOMEDCT_US_2016_03_01:111306001 UMLS_CUI:C0175704 Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome Cardiocutaneous syndrome Generalized lentiginosis (disorder) Gorlin syndrome II Lentiginosis profusa syndrome Moynahan syndrome Multiple lentigines syndrome (disorder) Progressive cardiomyopathic lentiginosis disease_ontology LEOPARD syndrome DOID:14291 OMIM mapping confirmed by DO. [SN]. LEOPARD syndrome DOID:1432 ICD10CM:H54 ICD9CM:369 SNOMEDCT_US_2016_03_01:155146008 SNOMEDCT_US_2016_03_01:155150001 SNOMEDCT_US_2016_03_01:193698004 SNOMEDCT_US_2016_03_01:267729001 UMLS_CUI:C0155020 disease_ontology DOID:1432 blindness DOID:14320 An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation. ICD10CM:F41.1 ICD9CM:300.02 NCI:C92622 SNOMEDCT_US_2016_03_01:191706008 SNOMEDCT_US_2016_03_01:192401002 SNOMEDCT_US_2016_03_01:21897009 UMLS_CUI:C0270549 disease_ontology DOID:14320 generalized anxiety disorder DOID:14330 A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. EFO:0002508 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:168600 OMIM:300557 OMIM:556500 OMIM:602404 OMIM:606852 OMIM:613164 ORDO:2828 SNOMEDCT_US_2016_03_01:154999006 SNOMEDCT_US_2016_03_01:155000006 SNOMEDCT_US_2016_03_01:155002003 SNOMEDCT_US_2016_03_01:192825001 SNOMEDCT_US_2016_03_01:192831003 SNOMEDCT_US_2016_03_01:49049000 UMLS_CUI:C0030567 Parkinson disease paralysis agitans disease_ontology DOID:14330 Xref MGI. OMIM mapping confirmed by DO. [SN]. Parkinson's disease DOID:14336 ICD10CM:E28.0 ICD9CM:256.0 NCI:C113344 SNOMEDCT_US_2016_03_01:190533004 SNOMEDCT_US_2016_03_01:37295009 UMLS_CUI:C0154209 hyperestrogenism disease_ontology DOID:14336 estrogen excess DOID:1436 ICD10CM:H18.71 ICD9CM:371.71 SNOMEDCT_US_2016_03_01:14748007 UMLS_CUI:C0155135 disease_ontology DOID:1436 corneal ectasia DOID:1441 A hereditary ataxia that has_material_basis_in autosomal dominant inheritance. DOID:2478 ICD9CM:334.3 MESH:D020754 NCI:C82341 SNOMEDCT_US_2016_03_01:129609000 UMLS_CUI:C0029534 UMLS_CUI:C0087012 spinocerebellar ataxia disease_ontology DOID:1441 autosomal dominant cerebellar ataxia DOID:14418 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection. ICD10CM:B72 ICD9CM:125.7 MESH:D004320 NCI:C84677 SNOMEDCT_US_2016_03_01:396334002 SNOMEDCT_US_2016_03_01:48874008 UMLS_CUI:C0013100 Dracontiasis Infection by Dracunculus medinensis Infection by Dracunculus medinensis (disorder) disease_ontology DOID:14418 dracunculiasis DOID:1442 A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions. ICD10CM:G31.81 MESH:D002549 NCI:C35257 OMIM:203700 SNOMEDCT_US_2016_03_01:20415001 UMLS_CUI:C0205710 ALPERS PROGRESSIVE INFANTILE POLIODYSTROPHY ALPERS-HUTTENLOCHER SYNDROME Alper's syndrome Alpers' disease or gray-matter degeneration MITOCHONDRIAL DNA DEPLETION SYNDROME 4A progressive sclerosing poliodystrophy disease_ontology DOID:1442 OMIM mapping confirmed by DO. [SN]. Alpers syndrome DOID:1443 ICD9CM:331.9 SNOMEDCT_US_2016_03_01:154994001 SNOMEDCT_US_2016_03_01:154998003 SNOMEDCT_US_2016_03_01:192824002 SNOMEDCT_US_2016_03_01:267579001 SNOMEDCT_US_2016_03_01:267686002 SNOMEDCT_US_2016_03_01:267688001 SNOMEDCT_US_2016_03_01:418143002 SNOMEDCT_US_2016_03_01:52522001 SNOMEDCT_US_2016_03_01:73768007 UMLS_CUI:C0154671 Brain degeneration disease_ontology DOID:1443 cerebral degeneration DOID:14443 An urticaria induced by sweating. ICD10CM:L50.5 ICD9CM:708.5 SNOMEDCT_US_2016_03_01:73098005 UMLS_CUI:C0152230 disease_ontology DOID:14443 cholinergic urticaria DOID:14447 A hypogonadism that is characterized by a progressive loss of germ cells on the developing gonads of an embryo. ICD9CM:758.6 MESH:D006059 NCI:C61420 SNOMEDCT_US_2016_03_01:157020008 SNOMEDCT_US_2016_03_01:205681004 SNOMEDCT_US_2016_03_01:205692003 SNOMEDCT_US_2016_03_01:205695001 SNOMEDCT_US_2016_03_01:268356004 SNOMEDCT_US_2016_03_01:38804009 UMLS_CUI:C0018051 Gonadal dysgenesis syndrome disease_ontology DOID:14447 gonadal dysgenesis DOID:14448 A gonadal dysgenesis that is characterized by a normal 46,XY karyotype along with a progressive loss of germ cells on the developing gonads of an embryo. MESH:D006061 NCI:C120198 OMIM:154230 OMIM:233420 OMIM:300018 OMIM:400044 OMIM:607080 OMIM:612965 OMIM:613080 OMIM:613762 OMIM:614279 OMIM:616067 UMLS_CUI:C0018054 46,XY SEX REVERSAL Pure gonadal dysgenesis 46,XY Swyer syndrome disease_ontology DOID:14448 The term 46,XY DSD has replaced the following terms Male pseudohermaphrodite, Undervirilization of an XY male, Undermasculinization of an XY male, Mixed gonadal dysgenesis, Partial gonadal dysgenesis. OMIM mapping confirmed by DO. [SN]. OMIM mapping confirmed by DO. [LS]. 46 XY gonadal dysgenesis DOID:14449 MESH:D006060 SNOMEDCT_US_2016_03_01:205682006 SNOMEDCT_US_2016_03_01:83579008 UMLS_CUI:C0018055 disease_ontology DOID:14449 mixed gonadal dysgenesis DOID:14451 ICD10CM:G72.3 MESH:D020513 NCI:C123429 OMIM:170500 SNOMEDCT_US_2016_03_01:15973007 SNOMEDCT_US_2016_03_01:278513006 SNOMEDCT_US_2016_03_01:304737009 UMLS_CUI:C0238357 familial hyperkalemic periodic paralysis (disorder) familial hyperkalemic periodic paralysis (disorder) [Ambiguous] hyperkalemic periodic paralysis (disorder) disease_ontology DOID:14451 OMIM mapping confirmed by DO. [SN]. hyperkalemic periodic paralysis DOID:14452 ICD10CM:G72.3 MESH:D020514 NCI:C84775 OMIM:170400 OMIM:613345 SNOMEDCT_US_2016_03_01:193241004 SNOMEDCT_US_2016_03_01:240093008 SNOMEDCT_US_2016_03_01:82732003 UMLS_CUI:C0238358 Hypokalemic familial periodic paralysis Hypokalemic periodic paralysis (disorder) Periodic paralysis I familial hypokalemic periodic paralysis (disorder) familial periodic paralysis (& [hypokalaemic]) periodic hypokalemic paralysis disease_ontology DOID:14452 OMIM mapping confirmed by DO. [SN]. hypokalemic periodic paralysis DOID:14464 A nervous system disease that is characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness and is associated with administration of antipsychotic and other central dopaminergic blockers. ICD10CM:G21.0 ICD9CM:333.92 MESH:D009459 NCI:C94829 ORDO:94093 SNOMEDCT_US_2016_03_01:15244003 SNOMEDCT_US_2016_03_01:192826000 SNOMEDCT_US_2016_03_01:68977009 UMLS_CUI:C0027849 disease_ontology DOID:14464 neuroleptic malignant syndrome DOID:14472 A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications. MESH:D018804 NCI:C84747 SNOMEDCT_US_2016_03_01:120639003 UMLS_CUI:C0243025 disease_ontology DOID:14472 hantavirus pulmonary syndrome DOID:14484 A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation. ICD10CM:B42 ICD10CM:B42.9 ICD9CM:117.1 MESH:D013174 SNOMEDCT_US_2016_03_01:154408001 SNOMEDCT_US_2016_03_01:187078008 SNOMEDCT_US_2016_03_01:187488001 SNOMEDCT_US_2016_03_01:266218008 SNOMEDCT_US_2016_03_01:42094007 UMLS_CUI:C0038034 disease_ontology DOID:14484 sporotrichosis DOID:14503 ICD10CM:E75.4 MESH:D009472 NCI:C61257 OMIM:PS256730 ORDO:216 ORDO:79262 SNOMEDCT_US_2016_03_01:42012007 UMLS_CUI:C0027877 hereditary ceroid lipofuscinosis disease_ontology DOID:14503 Xref MGI. OMIM mapping submitted by NeuroDevNet. [LS]. neuronal ceroid lipofuscinosis DOID:14515 A chromosomal deletion syndrome that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes. MESH:D017624 NCI:C3718 OMIM:194072 SNOMEDCT_US_2016_03_01:4135001 UMLS_CUI:C0206115 11p partial monosomy syndrome (disorder) Wilms tumor-Aniridia-Genitourinary Anomalies-Mental Retardation syndrome chromosome 11p13 deletion syndrome disease_ontology DOID:14515 OMIM mapping confirmed by DO. [LS]. WAGR syndrome DOID:14550 MESH:D012391 UMLS_CUI:C0035851 disease_ontology DOID:14550 root resorption DOID:14557 A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling. ICD10CM:I27.0 ICD9CM:416.0 NCI:C97119 OMIM:178600 OMIM:265400 OMIM:615342 OMIM:615343 OMIM:615344 ORDO:422 SNOMEDCT_US_2016_03_01:155328008 SNOMEDCT_US_2016_03_01:26174007 SNOMEDCT_US_2016_03_01:266293003 UMLS_CUI:C0152171 disease_ontology DOID:14557 Xref MGI. OMIM mapping confirmed by DO. [SN]. primary pulmonary hypertension DOID:14566 A disease that is characterized by abnormally rapid cell division. DOID:0000818 cell process disease neoplasm disease_ontology DOID:14566 disease of cellular proliferation DOID:1459 A thyroid gland disease which involves an underproduction of thyroid hormone. DOID:11630 EFO:0004705 ICD10CM:E03.9 ICD9CM:244.9 MESH:D007037 NCI:C26800 SNOMEDCT_US_2016_03_01:154660000 SNOMEDCT_US_2016_03_01:190274003 SNOMEDCT_US_2016_03_01:190290003 SNOMEDCT_US_2016_03_01:237572004 SNOMEDCT_US_2016_03_01:267377003 SNOMEDCT_US_2016_03_01:267465007 SNOMEDCT_US_2016_03_01:40930008 UMLS_CUI:C0020676 Thyroid deficiency Thyroid insufficiency disease_ontology DOID:1459 hypothyroidism DOID:14669 A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency. MESH:C538179 OMIM:101800 OMIM:614613 SNOMEDCT_US_2016_03_01:66758006 UMLS_CUI:C0220659 disease_ontology DOID:14669 OMIM mapping confirmed by DO. [SN]. acrodysostosis DOID:14679 A syndrome that is characterized by the presence of at least three of the following: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities. ICD10CM:Q87.2 MESH:C536534 OMIM:192350 OMIM:276950 SNOMEDCT_US_2016_03_01:205830006 SNOMEDCT_US_2016_03_01:27742002 UMLS_CUI:C0220708 VACTERL/VATER association vater ASSOCIATION vater association (disorder) vater association [dup] (disorder) disease_ontology VATER syndrome DOID:14679 OMIM mapping confirmed by DO. [LS]. VACTERL association DOID:14681 ICD10CM:Q87.1 MESH:D056730 NCI:C85068 OMIM:180860 SNOMEDCT_US_2016_03_01:15069006 UMLS_CUI:C0175693 Silver Russell Dwarfism disease_ontology DOID:14681 OMIM mapping confirmed by DO. [LS]. Silver-Russell syndrome DOID:14687 An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism. ICD10CM:Q77.5 MESH:C536170 OMIM:222600 SNOMEDCT_US_2016_03_01:58561002 UMLS_CUI:C0220726 disease_ontology DOID:14687 OMIM mapping confirmed by DO. [SN]. diastrophic dysplasia DOID:14692 DOID:4366 ICD10CM:E78.72 MESH:D019082 NCI:C85071 OMIM:270400 SNOMEDCT_US_2016_03_01:43929004 UMLS_CUI:C0175694 Rutledge lethal multiple congenital anomaly syndrome Smith-Opitz-Inborn syndrome disease_ontology DOID:14692 OMIM mapping confirmed by DO. [LS]. Smith-Lemli-Opitz syndrome DOID:14693 MESH:D004476 OMIM:129500 SNOMEDCT_US_2016_03_01:54209007 UMLS_CUI:C0162361 Clouston's hidrotic ectodermal dysplasia Clouston's syndrome Hidrotic ectodermal dysplasia syndrome (disorder) hidrotic ectodermal dysplasia disease_ontology DOID:14693 OMIM mapping confirmed by DO. [SN]. Clouston syndrome DOID:14699 ICD10CM:Q87.2 MESH:C536940 NCI:C99038 OMIM:274000 SNOMEDCT_US_2016_03_01:85589009 UMLS_CUI:C0175703 Radial aplasia-thrombocytopenia syndrome (disorder) Thrombocytopenia with absent radii (TAR) syndrome chromosome 1q21.1 deletion syndrome disease_ontology DOID:14699 OMIM mapping confirmed by DO. [LS]. thrombocytopenia-absent radius syndrome DOID:1470 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities. DOID:10614 DOID:2240 DOID:2241 DOID:7580 ICD10CM:F32 ICD10CM:F32.9 ICD10CM:F33 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 MESH:D003865 NCI:C34796 OMIM:608520 OMIM:608691 SNOMEDCT_US_2016_03_01:191599006 SNOMEDCT_US_2016_03_01:191600009 SNOMEDCT_US_2016_03_01:191607007 SNOMEDCT_US_2016_03_01:191608002 SNOMEDCT_US_2016_03_01:191609005 SNOMEDCT_US_2016_03_01:191617002 SNOMEDCT_US_2016_03_01:192366006 SNOMEDCT_US_2016_03_01:268620009 SNOMEDCT_US_2016_03_01:268621008 SNOMEDCT_US_2016_03_01:36923009 SNOMEDCT_US_2016_03_01:66344007 UMLS_CUI:C0024517 UMLS_CUI:C0154409 recurrent major depression single major depressive episode disease_ontology DOID:1470 Xref MGI. major depressive disorder DOID:14705 An acrocephalosyndactylia that has_material_basis_in mutations in the FGFR1 and FGFR2 gene which results_in premature fusion located_in skull. MESH:D000168 NCI:C99100 OMIM:101600 SNOMEDCT_US_2016_03_01:70410008 UMLS_CUI:C0220658 acrocephalosyndactylia type V disease_ontology DOID:14705 OMIM mapping confirmed by DO. [SN]. Pfeiffer syndrome DOID:14711 An X-linked disease characterized by retardation, hyperactivity, hypotonia, broad thumbs, big first toes and a characteristic facial appearance including macrocephaly and has an X-linked recessive inheritance pattern. MESH:C537923 OMIM:300321 OMIM:300406 OMIM:300422 OMIM:300581 OMIM:305450 ORDO:323 ORDO:93932 SNOMEDCT_US_2016_03_01:49984004 UMLS_CUI:C0220769 Keller syndrome Opitz-Kaveggia syndrome disease_ontology DOID:14711 Xref MGI. OMIM mapping confirmed by DO. [SN]. FG syndrome DOID:14717 A myopathy characterized by abnormally located nuclei in skeletal muscle cells. The nuclei are located in the center of the cell, instead of their normal location at the periphery. MESH:D020914 NCI:C84648 OMIM:160150 OMIM:255200 OMIM:310400 OMIM:614408 OMIM:614807 OMIM:615959 ORDO:595 ORDO:596 ORDO:69186 ORDO:69189 SNOMEDCT_US_2016_03_01:193223007 SNOMEDCT_US_2016_03_01:82077006 UMLS_CUI:C0175709 myotubular myopathy disease_ontology DOID:14717 Xref MGI. centronuclear myopathy DOID:14737 MESH:C536456 OMIM:304110 UMLS_CUI:C0220767 craniofrontonasal dysplasia disease_ontology DOID:14737 OMIM mapping confirmed by DO. [SN]. craniofrontonasal syndrome DOID:1474 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium. ICD10CM:K05.2 MESH:D010520 OMIM:170650 OMIM:608526 SNOMEDCT_US_2016_03_01:2624008 SNOMEDCT_US_2016_03_01:449908004 SNOMEDCT_US_2016_03_01:49965002 UMLS_CUI:C0031106 juvenile periodontitis disease_ontology DOID:1474 OMIM mapping confirmed by DO. [SN]. aggressive periodontitis DOID:14744 A syndrome characterized by intellectual disability, focal dystonia of the hands and dysarthria. MESH:C562446 OMIM:309510 OMIM:312780 ORDO:94083 UMLS_CUI:C0220775 X-linked Russell-Silver syndrome disease_ontology DOID:14744 OMIM mapping confirmed by DO. [SN]. OMIM mapping submitted by NeuroDevNet. [LS]. Partington syndrome DOID:14748 An autosomal recessive disease that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life. ICD10CM:Q87.3 MESH:D058495 NCI:C75019 OMIM:117550 OMIM:614753 ORDO:821 SNOMEDCT_US_2016_03_01:75968004 UMLS_CUI:C0175695 cerebral gigantism disease_ontology DOID:14748 Xref MGI. Sotos syndrome DOID:14749 An organic acidemia that involves an accumulation of methylmalonic acid in the blood. DOID:14782 DOID:14802 METHYLMALONIC ACIDEMIA, cblA TYPE METHYLMALONIC ACIDEMIA, cblB TYPE METHYLMALONIC ACIDURIA DUE TO METHYLMALONYL-CoA MUTASE DEFICIENCY METHYLMALONIC ACIDURIA, VITAMIN B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN, cblA TYPE METHYLMALONIC ACIDURIA, VITAMIN B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN, cblB TYPE METHYLMALONIC ACIDURIA, mut TYPE METHYLMALONICACIDURIA DUE TO METHYLMALONIC CoA MUTASE deficiency METHYLMALONICACIDURIA, vitamin B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN--cbl A METHYLMALONICACIDURIA, vitamin B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN--cbl B methylmalonic aciduria methylmalonic aciduria cblB type methylmalonic aciduria mut type methylmalonic aciduria type cblA methylmalonic aciduria type cblB disease_ontology DOID:14749 OMIM mapping confirmed by DO. [SN]. methylmalonic acidemia DOID:1475 ICD10CM:D18.1 ICD9CM:228.1 MESH:D008202 NCI:C8965 SNOMEDCT_US_2016_03_01:154625006 SNOMEDCT_US_2016_03_01:189200000 SNOMEDCT_US_2016_03_01:189875000 SNOMEDCT_US_2016_03_01:253057002 SNOMEDCT_US_2016_03_01:254836000 SNOMEDCT_US_2016_03_01:269646001 SNOMEDCT_US_2016_03_01:400178008 SNOMEDCT_US_2016_03_01:69044001 SNOMEDCT_US_2016_03_01:93168006 UMLS_CUI:C0024221 Congenital lymphangioma benign lymphangioma (morphologic abnormality) disease_ontology DOID:1475 lymphangioma DOID:14753 An organic acidemia that disrupts or prevents normal metabolism of the branched-chain amino acid leucine. ICD10CM:E71.110 MESH:C538167 NCI:C98964 OMIM:243500 SNOMEDCT_US_2016_03_01:87827003 UMLS_CUI:C0268575 Isovaleryl-CoA dehydrogenase deficiency (disorder) isovaleric acid CoA dehydrogenase deficiency isovaleric aciduria disease_ontology DOID:14753 OMIM mapping confirmed by DO. [SN]. isovaleric acidemia DOID:14766 OMIM:191830 hereditary renal aplasia hereditary urogenital adysplasia renal adysplasia renal aplasia disease_ontology DOID:14766 renal agenesis DOID:14791 A retinal disease that is characterized by nystagmus, sluggish or no pupillary responses, and severe vision loss or blindness. MESH:D057130 OMIM:PS204000 ORDO:65 SNOMEDCT_US_2016_03_01:193413001 UMLS_CUI:C0339527 LCA Leber's amaurosis Leber's congenital amaurosis Leber's disease disease_ontology DOID:14791 Xref MGI. OMIM mapping confirmed by DO. [SN]. Leber congenital amaurosis DOID:14793 A monogenic disease that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth). DOID:0050446 DOID:0050447 MESH:D053358 NCI:C84562 OMIM:129490 OMIM:224900 OMIM:300291 OMIM:305100 SNOMEDCT_US_2016_03_01:239007005 SNOMEDCT_US_2016_03_01:4826006 SNOMEDCT_US_2016_03_01:7731005 UMLS_CUI:C0162359 Christ-Siemens-Touraine Syndrome Ectodermal Dysplasia 1, Anhydrotic Hypohidrotic X-linked ectodermal dysplasia (disorder) anhidrotic ectodermal dysplasia 3 disease_ontology DOID:14793 OMIM mapping confirmed by DO. [SN]. hypohidrotic ectodermal dysplasia DOID:1483 MESH:D005882 SNOMEDCT_US_2016_03_01:155642009 SNOMEDCT_US_2016_03_01:18718003 SNOMEDCT_US_2016_03_01:266489007 UMLS_CUI:C0017563 disease_ontology DOID:1483 gingival disease DOID:1485 An autosomal recessive disease that is characterized by the buildup of thick, sticky mucus that can damage many organs. DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD10CM:E84.9 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 SNOMEDCT_US_2016_03_01:154767009 SNOMEDCT_US_2016_03_01:190905008 SNOMEDCT_US_2016_03_01:190911006 SNOMEDCT_US_2016_03_01:85809002 UMLS_CUI:C0010674 CF mucoviscidosis disease_ontology DOID:1485 OMIM mapping confirmed by DO. [SN]. cystic fibrosis DOID:1492 A sensory system disease that is located_in the eye or the adnexa of the eye. ICD10CM:H35.00 ICD9CM:362.10 SNOMEDCT_US_2016_03_01:193355009 SNOMEDCT_US_2016_03_01:31411005 SNOMEDCT_US_2016_03_01:42873008 UMLS_CUI:C0004608 disease_ontology DOID:1492 eye and adnexa disease DOID:1496 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys. DOID:12149 DOID:2783 ICD10CM:B67 ICD10CM:B67.90 ICD9CM:122 MESH:D004443 NCI:C84682 SNOMEDCT_US_2016_03_01:154414008 SNOMEDCT_US_2016_03_01:187143006 SNOMEDCT_US_2016_03_01:74942003 UMLS_CUI:C0013502 Echinococcosis of liver (disorder) Echinococcosis, unspecified, of liver Echinococcosis, unspecified, of liver (disorder) Liver echinococcus unspecified (disorder) echinococcal disease hepatic echinococcosis hydatid disease hydatidosis pulmonary echinococcosis disease_ontology DOID:1496 echinococcosis DOID:1498 A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock. ICD10CM:A00 ICD10CM:A00.0 ICD10CM:A00.9 ICD9CM:001 ICD9CM:001.0 ICD9CM:001.9 MESH:D002771 SNOMEDCT_US_2016_03_01:154269008 SNOMEDCT_US_2016_03_01:186087007 SNOMEDCT_US_2016_03_01:186088002 SNOMEDCT_US_2016_03_01:186089005 SNOMEDCT_US_2016_03_01:187267007 SNOMEDCT_US_2016_03_01:61972007 SNOMEDCT_US_2016_03_01:63650001 UMLS_CUI:C0008354 (Cholera) or (Vibrio cholerae) Cholera - Vibrio cholerae (disorder) Cholera due to Vibrio cholerae disease_ontology DOID:1498 cholera DOID:15 A disease of anatomical entity that is located_in reproductive system organs. DOID:6309 NCI:C27613 UMLS_CUI:C1335037 genital system disease disease_ontology DOID:15 reproductive system disease DOID:150 A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. ICD10CM:F99 ICD10CM:F99-F99 MESH:D001523 NCI:C2893 SNOMEDCT_US_2016_03_01:154843007 SNOMEDCT_US_2016_03_01:154971002 SNOMEDCT_US_2016_03_01:154972009 SNOMEDCT_US_2016_03_01:154980002 SNOMEDCT_US_2016_03_01:192637001 SNOMEDCT_US_2016_03_01:192639003 SNOMEDCT_US_2016_03_01:74732009 UMLS_CUI:C0004936 disease_ontology DOID:150 disease of mental health DOID:1508 An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons. DOID:1507 ICD10CM:B37 ICD10CM:B37.9 ICD9CM:112 ICD9CM:112.9 MESH:D002177 NCI:C26711 SNOMEDCT_US_2016_03_01:154403005 SNOMEDCT_US_2016_03_01:187005005 SNOMEDCT_US_2016_03_01:187024008 SNOMEDCT_US_2016_03_01:187478002 SNOMEDCT_US_2016_03_01:78048006 UMLS_CUI:C0006840 Disseminated candidiasis systemic candidiasis disease_ontology DOID:1508 candidiasis DOID:1510 A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. ICD9CM:301.8 ICD9CM:301.89 SNOMEDCT_US_2016_03_01:191770003 SNOMEDCT_US_2016_03_01:191776009 SNOMEDCT_US_2016_03_01:268635005 SNOMEDCT_US_2016_03_01:268759009 UMLS_CUI:C0029707 character disorder disease_ontology DOID:1510 personality disorder DOID:1518 An intestinal disease located_in the cecum. MESH:D002429 SNOMEDCT_US_2016_03_01:128525008 UMLS_CUI:C0007527 disorder of cecum (disorder) disease_ontology DOID:1518 cecal disease DOID:1519 A cecum cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C3491 SNOMEDCT_US_2016_03_01:154459000 SNOMEDCT_US_2016_03_01:187756005 SNOMEDCT_US_2016_03_01:255081007 SNOMEDCT_US_2016_03_01:269538009 UMLS_CUI:C0149640 Caecum carcinoma Cecal cancer carcinoma of cecum disease_ontology DOID:1519 cecum carcinoma DOID:1520 A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C4910 OMIM:114500 SNOMEDCT_US_2016_03_01:154454005 SNOMEDCT_US_2016_03_01:269533000 UMLS_CUI:C0699790 Colonic carcinoma carcinoma OF colon carcinoma of colon carcinoma of colon (disorder) disease_ontology DOID:1520 OMIM mapping confirmed by DO. [SN]. colon carcinoma DOID:1521 A large intestine cancer that is located_in the cecum. ICD10CM:C18.0 ICD9CM:153.4 MESH:D002430 NCI:C9329 SNOMEDCT_US_2016_03_01:154459000 SNOMEDCT_US_2016_03_01:187756005 SNOMEDCT_US_2016_03_01:269538009 SNOMEDCT_US_2016_03_01:363350007 SNOMEDCT_US_2016_03_01:93736007 UMLS_CUI:C0153437 malignant neoplasm of caecum malignant tumor of the cecum disease_ontology DOID:1521 cecum cancer DOID:1532 A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. DOID:1531 MESH:D010995 NCI:C26859 SNOMEDCT_US_2016_03_01:88075009 UMLS_CUI:C0032226 disorder of pleura non-neoplastic pleural disease disease_ontology DOID:1532 pleural disease DOID:154 A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from two germinal layers of tissue. DOID:1905 MESH:D018198 NCI:C3729 NCI:C6930 SNOMEDCT_US_2016_03_01:189802003 SNOMEDCT_US_2016_03_01:8145008 UMLS_CUI:C0206625 UMLS_CUI:C1368354 malignant mixed cancer malignant mixed neoplasm mixed tumor mixed tumor, malignant (morphologic abnormality) mixed tumor, malignant, NOS (morphologic abnormality) disease_ontology malignant mixed tumor mixed neoplasm DOID:154 mixed cell type cancer DOID:1542 A head and neck cancer that has_material_basis_in epithelial cells and is located_in the upper aerodigestive tract, including the lip, oral cavity (mouth), nasal cavity, paranasal sinuses, pharynx, and larynx. NCI:C6077 UMLS_CUI:C1334927 carcinoma of the neck disease_ontology carcinoma of neck DOID:1542 head and neck carcinoma DOID:1555 A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located_in the upper dermis. ICD9CM:708.8 SNOMEDCT_US_2016_03_01:201267004 SNOMEDCT_US_2016_03_01:201271001 SNOMEDCT_US_2016_03_01:267817001 UMLS_CUI:C0029839 disease_ontology DOID:1555 urticaria DOID:1556 ICD10CM:T78.41 ICD9CM:995.21 MESH:D001183 NCI:C34400 SNOMEDCT_US_2016_03_01:29548007 SNOMEDCT_US_2016_03_01:402413008 UMLS_CUI:C0003907 Arthus Phenomenon Arthus phenomenon Arthus reaction (function) Arthus type urticaria disease_ontology DOID:1556 arthus reaction DOID:1557 MESH:D007105 UMLS_CUI:C0020951 immune complex disease disease_ontology DOID:1557 hypersensitivity reaction type III disease DOID:1558 A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues. CSP:2716-7007 ICD10CM:T78.3 MESH:D000799 NCI:C112175 SNOMEDCT_US_2016_03_01:157756002 SNOMEDCT_US_2016_03_01:269433002 SNOMEDCT_US_2016_03_01:400075008 SNOMEDCT_US_2016_03_01:41291007 SNOMEDCT_US_2016_03_01:82966003 UMLS_CUI:C0002994 Angioneurotic oedema Quincke's edema angioneurotic edema giant urticaria disease_ontology DOID:1558 angioedema DOID:1561 A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. ICD10CM:F09 MESH:D019965 NCI:C34870 SNOMEDCT_US_2016_03_01:106014008 SNOMEDCT_US_2016_03_01:111479008 UMLS_CUI:C0029227 cognitive disease disease_ontology Organic Mental disorder DOID:1561 cognitive disorder DOID:1564 A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body. ICD10CM:B35-B49 ICD10CM:B49 ICD9CM:110-118.99 MESH:D009181 NCI:C3245 SNOMEDCT_US_2016_03_01:154393000 SNOMEDCT_US_2016_03_01:154394006 SNOMEDCT_US_2016_03_01:187110007 SNOMEDCT_US_2016_03_01:187472001 SNOMEDCT_US_2016_03_01:187498007 SNOMEDCT_US_2016_03_01:266214005 SNOMEDCT_US_2016_03_01:3218000 UMLS_CUI:C0026946 mycosis disease_ontology mycoses DOID:1564 fungal infectious disease DOID:1570 ICD10CM:H02.1 ICD10CM:H02.10 ICD10CM:H02.109 ICD9CM:374.1 ICD9CM:374.10 MESH:D004483 SNOMEDCT_US_2016_03_01:127559009 SNOMEDCT_US_2016_03_01:155178000 SNOMEDCT_US_2016_03_01:193934003 SNOMEDCT_US_2016_03_01:193935002 SNOMEDCT_US_2016_03_01:62909004 UMLS_CUI:C0013592 Ectropion of eyelid Everted margin disease_ontology DOID:1570 ectropion DOID:1575 A hypersensitivity reaction type II disease that involves inflammation or pain in the muscles, joints, or fibrous tissue. disease_ontology DOID:1575 rheumatic disease DOID:1579 A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. DOID:3226 ICD10CM:J96-J99 ICD10CM:J98 ICD9CM:510-519.99 ICD9CM:519 SNOMEDCT_US_2016_03_01:155603009 SNOMEDCT_US_2016_03_01:196057004 SNOMEDCT_US_2016_03_01:196184000 SNOMEDCT_US_2016_03_01:196255004 SNOMEDCT_US_2016_03_01:266373008 UMLS_CUI:C0029582 disease_ontology DOID:1579 respiratory system disease DOID:1588 A blood platelet disease characterized by low a platelet count in the blood. ICD10CM:D69.6 ICD9CM:287.5 MESH:D013921 NCI:C3408 OMIM:188000 OMIM:273900 OMIM:300367 OMIM:313900 OMIM:612004 ORDO:852 SNOMEDCT_US_2016_03_01:142969008 SNOMEDCT_US_2016_03_01:154827000 SNOMEDCT_US_2016_03_01:165556002 SNOMEDCT_US_2016_03_01:191326009 SNOMEDCT_US_2016_03_01:302215000 SNOMEDCT_US_2016_03_01:415116008 SNOMEDCT_US_2016_03_01:70786006 UMLS_CUI:C0040034 disease_ontology DOID:1588 Xref MGI. thrombocytopenia DOID:1591 ICD10CM:I15.0 MESH:D006978 NCI:C85044 SNOMEDCT_US_2016_03_01:123799005 SNOMEDCT_US_2016_03_01:194790006 UMLS_CUI:C0020545 Renovascular hypertension (disorder) disease_ontology DOID:1591 renovascular hypertension DOID:1595 A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system. DOID:6340 EFO:0003761 MESH:D003866 NCI:C34532 NCI:C35094 OMIM:608516 SNOMEDCT_US_2016_03_01:154873003 SNOMEDCT_US_2016_03_01:191599006 SNOMEDCT_US_2016_03_01:231498003 SNOMEDCT_US_2016_03_01:300706003 UMLS_CUI:C0011573 UMLS_CUI:C0041696 clinical depression unipolar depression disease_ontology DOID:1595 OMIM mapping confirmed by DO. [LS]. endogenous depression DOID:1596 DOID:14672 ICD10CM:F32.9 ICD10CM:F33.9 MESH:D003863 NCI:C2982 SNOMEDCT_US_2016_03_01:154963001 SNOMEDCT_US_2016_03_01:192372006 SNOMEDCT_US_2016_03_01:307537002 SNOMEDCT_US_2016_03_01:41006004 UMLS_CUI:C0011570 disease_ontology DOID:1596 mental depression DOID:16 A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages. disease_ontology DOID:16 integumentary system disease DOID:1602 DOID:1600 DOID:9941 ICD10CM:I88.1 ICD10CM:I88.9 ICD10CM:L04 ICD10CM:L04.9 ICD9CM:289.1 ICD9CM:683 MESH:D008199 NCI:C26821 NCI:C26966 NCI:C26978 SNOMEDCT_US_2016_03_01:154836001 SNOMEDCT_US_2016_03_01:154838000 SNOMEDCT_US_2016_03_01:156318008 SNOMEDCT_US_2016_03_01:19471005 SNOMEDCT_US_2016_03_01:200696002 SNOMEDCT_US_2016_03_01:274737001 SNOMEDCT_US_2016_03_01:287688007 SNOMEDCT_US_2016_03_01:32035007 SNOMEDCT_US_2016_03_01:41174002 UMLS_CUI:C0024205 UMLS_CUI:C0154304 UMLS_CUI:C0157705 Adenitis Inflammation of lymph node acute adenitis acute lymphadenitis chronic Lymphadenitis chronic adenitis disease_ontology DOID:1602 lymphadenitis DOID:161 A skin disease characterized_by growth of keratin on the skin or mucous membranes. MESH:D007642 NCI:C34747 SNOMEDCT_US_2016_03_01:254666005 UMLS_CUI:C0022593 disease_ontology DOID:161 keratosis DOID:1612 A thoracic cancer that originates in the mammary gland. DOID:1648 DOID:4241 ICD10CM:C50 ICD10CM:C50-C50 ICD9CM:174.8 MESH:D001943 NCI:C2910 NCI:C9335 OMIM:114480 OMIM:600048 OMIM:605365 SNOMEDCT_US_2016_03_01:126926005 SNOMEDCT_US_2016_03_01:154521006 SNOMEDCT_US_2016_03_01:190121004 SNOMEDCT_US_2016_03_01:254837009 SNOMEDCT_US_2016_03_01:269595005 UMLS_CUI:C0006142 UMLS_CUI:C0153555 UMLS_CUI:C1458155 breast tumor malignant neoplasm of breast malignant tumor of the breast mammary cancer mammary tumor primary breast cancer disease_ontology mammary neoplasm DOID:1612 Xref MGI. OMIM mapping confirmed by DO. [SN]. breast cancer DOID:1618 A breast benign neoplasm comprised of fibrous and glandoular tissues located_in breast. DOID:2684 DOID:2693 DOID:7226 ICD10CM:D24 MESH:D018226 NCI:C3744 NCI:C4276 NCI:C5194 SNOMEDCT_US_2016_03_01:189102001 SNOMEDCT_US_2016_03_01:189820007 SNOMEDCT_US_2016_03_01:254845004 SNOMEDCT_US_2016_03_01:254847007 SNOMEDCT_US_2016_03_01:269640007 SNOMEDCT_US_2016_03_01:46212000 SNOMEDCT_US_2016_03_01:65877006 UMLS_CUI:C0178421 UMLS_CUI:C0206650 UMLS_CUI:C0346158 UMLS_CUI:C1333137 Complex Fibroadenoma of breast Fibroadenoma Fibroadenoma of breast (disorder) Juvenile fibroadenoma (morphologic abnormality) cellular Fibroadenoma fibroadenoma juvenile fibroadenoma of breast disease_ontology DOID:1618 breast fibroadenoma DOID:162 A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. ICD10CM:C80 ICD10CM:C80.1 ICD9CM:199 MESH:D009369 NCI:C9305 SNOMEDCT_US_2016_03_01:154432008 SNOMEDCT_US_2016_03_01:154433003 SNOMEDCT_US_2016_03_01:154577008 SNOMEDCT_US_2016_03_01:187597000 SNOMEDCT_US_2016_03_01:188475001 SNOMEDCT_US_2016_03_01:188482002 SNOMEDCT_US_2016_03_01:190150006 SNOMEDCT_US_2016_03_01:269513004 SNOMEDCT_US_2016_03_01:269623003 SNOMEDCT_US_2016_03_01:269626006 SNOMEDCT_US_2016_03_01:269634000 SNOMEDCT_US_2016_03_01:363346000 SNOMEDCT_US_2016_03_01:38807002 UMLS_CUI:C0006826 malignant neoplasm malignant tumor primary cancer disease_ontology DOID:162 Updating out dated UMLS CUI. cancer DOID:1625 NCI:C40382 SNOMEDCT_US_2016_03_01:269640007 UMLS_CUI:C1328385 Ademoma - breast disease_ontology DOID:1625 breast adenoma DOID:1657 A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles. ICD10CM:Q21.0 ICD9CM:745.4 MESH:D006345 NCI:C84506 OMIM:614429 OMIM:614431 OMIM:614432 ORDO:1480 SNOMEDCT_US_2016_03_01:156914003 SNOMEDCT_US_2016_03_01:204309000 SNOMEDCT_US_2016_03_01:204310005 SNOMEDCT_US_2016_03_01:204314001 SNOMEDCT_US_2016_03_01:253549006 SNOMEDCT_US_2016_03_01:270547008 SNOMEDCT_US_2016_03_01:30288003 UMLS_CUI:C0018818 Interventricular septal defect Ventricular septal abnormality disease_ontology DOID:1657 Xref MGI. ventricular septal defect DOID:1659 A brain cancer that is located_in the supratentorial region. DOID:1658 ICD10CM:C71.0 MESH:D015173 NCI:C3397 NCI:C4964 UMLS_CUI:C0038874 UMLS_CUI:C0751589 Brain neoplasm, Supratentorial malignant Supratentorial tumor disease_ontology DOID:1659 supratentorial cancer DOID:1664 A pineal gland neoplasm located_in the brain. MESH:D010871 NCI:C9344 SNOMEDCT_US_2016_03_01:31671006 UMLS_CUI:C0205898 Pineal PNET disease_ontology DOID:1664 pineoblastoma DOID:1673 ICD10CM:J93.1 SNOMEDCT_US_2016_03_01:196103008 SNOMEDCT_US_2016_03_01:196105001 SNOMEDCT_US_2016_03_01:196251008 SNOMEDCT_US_2016_03_01:266367007 UMLS_CUI:C0029850 disease_ontology DOID:1673 pneumothorax DOID:1679 ICD10CM:N30 ICD10CM:N30.9 ICD9CM:595 ICD9CM:595.9 MESH:D003556 NCI:C26738 SNOMEDCT_US_2016_03_01:155882000 SNOMEDCT_US_2016_03_01:155885003 SNOMEDCT_US_2016_03_01:197857009 SNOMEDCT_US_2016_03_01:266629000 SNOMEDCT_US_2016_03_01:38822007 UMLS_CUI:C0010692 disease_ontology DOID:1679 cystitis DOID:1680 ICD10CM:N30.2 ICD9CM:595.2 SNOMEDCT_US_2016_03_01:197839008 SNOMEDCT_US_2016_03_01:197842002 SNOMEDCT_US_2016_03_01:198536006 UMLS_CUI:C0156268 disease_ontology DOID:1680 chronic cystitis DOID:1681 ICD10CM:Q21 ICD10CM:Q21.9 MESH:D006343 NCI:C84482 SNOMEDCT_US_2016_03_01:156916001 SNOMEDCT_US_2016_03_01:204290008 SNOMEDCT_US_2016_03_01:253273004 SNOMEDCT_US_2016_03_01:287081002 SNOMEDCT_US_2016_03_01:396351009 SNOMEDCT_US_2016_03_01:59494005 SNOMEDCT_US_2016_03_01:8352002 UMLS_CUI:C0018816 Cardiac septal defects Cardiac septal defects (disorder) Congenital septal defect of heart (disorder) Septal defect NOS Septal defect NOS (disorder) septal defect disease_ontology DOID:1681 heart septal defect DOID:1682 ICD10CM:Q24.9 ICD9CM:746.9 MESH:D006330 NCI:C34666 SNOMEDCT_US_2016_03_01:13213009 SNOMEDCT_US_2016_03_01:156911006 SNOMEDCT_US_2016_03_01:156926008 SNOMEDCT_US_2016_03_01:204405005 SNOMEDCT_US_2016_03_01:204413006 SNOMEDCT_US_2016_03_01:268315002 SNOMEDCT_US_2016_03_01:268318000 UMLS_CUI:C0018798 Congenital Heart Defects Congenital anomaly of heart Heart Malformation congenital heart defect heart defect disease_ontology Heart-congenital defect DOID:1682 OMIM mapping confirmed by DO. [SN]. congenital heart disease DOID:1686 An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. EFO:0000516 ICD10CM:H40 ICD10CM:H40-H42 ICD10CM:H40.9 ICD9CM:365 ICD9CM:365.9 MESH:D005901 NCI:C26782 SNOMEDCT_US_2016_03_01:155120009 SNOMEDCT_US_2016_03_01:193569008 SNOMEDCT_US_2016_03_01:194631001 SNOMEDCT_US_2016_03_01:23986001 UMLS_CUI:C0017601 disease_ontology DOID:1686 glaucoma DOID:169 An endocrine gland cancer that has_material_basis_in neuroendocrine cells. ICD10CM:D3A.8 ICD9CM:209 ICD9CM:209-209.99 MESH:D018358 NCI:C3809 SNOMEDCT_US_2016_03_01:128928004 SNOMEDCT_US_2016_03_01:255046005 UMLS_CUI:C0206754 neuroendocrine neoplasm disease_ontology DOID:169 neuroendocrine tumor DOID:17 A disease of anatomical entity that occurs in the muscular and/or skeletal system. MESH:D009140 NCI:C107377 SNOMEDCT_US_2016_03_01:156881000 SNOMEDCT_US_2016_03_01:268047003 SNOMEDCT_US_2016_03_01:268142006 SNOMEDCT_US_2016_03_01:274149006 SNOMEDCT_US_2016_03_01:928000 UMLS_CUI:C0026857 disease_ontology DOID:17 musculoskeletal system disease DOID:170 An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system. DOID:10009 ICD10CM:C75.9 ICD9CM:194.9 MESH:D004701 NCI:C3010 NCI:C3575 SNOMEDCT_US_2016_03_01:127015005 SNOMEDCT_US_2016_03_01:190140005 SNOMEDCT_US_2016_03_01:363347009 SNOMEDCT_US_2016_03_01:371982006 SNOMEDCT_US_2016_03_01:387922007 SNOMEDCT_US_2016_03_01:387927001 SNOMEDCT_US_2016_03_01:93780007 UMLS_CUI:C0014132 UMLS_CUI:C0153658 Endocrine tumor endocrine neoplasm malignant Endocrine tumor malignant neoplasm of endocrine gland malignant tumour of endocrine gland neoplasm of endocrine gland (disorder) neoplasm of endocrine system (disorder) disease_ontology DOID:170 endocrine gland cancer DOID:1701 A lipid metabolism disorder that involves defects in steroid metabolism. MESH:D043202 UMLS_CUI:C1257809 disease_ontology DOID:1701 steroid inherited metabolic disorder DOID:1702 ICD10CM:Q80.0 MESH:D016112 NCI:C84778 OMIM:146700 SNOMEDCT_US_2016_03_01:20512000 SNOMEDCT_US_2016_03_01:205551004 SNOMEDCT_US_2016_03_01:254157005 UMLS_CUI:C0079584 Dominant congenital ichthyosiform erythroderma (disorder) disease_ontology DOID:1702 OMIM mapping confirmed by DO. [SN]. ichthyosis vulgaris DOID:171 MESH:D017599 SNOMEDCT_US_2016_03_01:253096008 SNOMEDCT_US_2016_03_01:73676002 UMLS_CUI:C0206093 primitive Neuroectodermal neoplasm disease_ontology DOID:171 neuroectodermal tumor DOID:1712 An aortic valve disease that has_physical_basis_in incomplete opening of the aortic valve. DOID:12034 DOID:1711 ICD10CM:I06.0 ICD10CM:Q23.0 ICD9CM:395.0 ICD9CM:746.3 MESH:D001024 NCI:C50462 OMIM:109730 OMIM:614823 ORDO:402075 SNOMEDCT_US_2016_03_01:155282009 SNOMEDCT_US_2016_03_01:156922005 SNOMEDCT_US_2016_03_01:18546004 SNOMEDCT_US_2016_03_01:390722003 SNOMEDCT_US_2016_03_01:60573004 SNOMEDCT_US_2016_03_01:72011007 UMLS_CUI:C0003507 UMLS_CUI:C0152417 UMLS_CUI:C0155567 AS Aortic stenosis Congenital aortic valve stenosis Rheumatic aortic stenosis rheumatic aortic valve stenosis disease_ontology DOID:1712 Xref MGI. OMIM mapping confirmed by DO. [SN]. aortic valve stenosis DOID:1724 DOID:10297 DOID:11480 DOID:12880 DOID:13836 DOID:1723 DOID:9780 DOID:9781 DOID:9782 DOID:9783 ICD10CM:K26 ICD9CM:532 MESH:D004381 NCI:C26755 SNOMEDCT_US_2016_03_01:155691003 SNOMEDCT_US_2016_03_01:155700000 SNOMEDCT_US_2016_03_01:196651004 SNOMEDCT_US_2016_03_01:196669008 SNOMEDCT_US_2016_03_01:196672001 SNOMEDCT_US_2016_03_01:196679005 SNOMEDCT_US_2016_03_01:196680008 SNOMEDCT_US_2016_03_01:235703009 SNOMEDCT_US_2016_03_01:367474008 SNOMEDCT_US_2016_03_01:39755000 SNOMEDCT_US_2016_03_01:51868009 SNOMEDCT_US_2016_03_01:553009 UMLS_CUI:C0010474 UMLS_CUI:C0013295 Curling Ulcer Curling's ulcers Stress Ulcer disease_ontology DOID:1724 Adding UMLS CUI for Curling Ulcer C0013295. duodenal ulcer DOID:1727 MESH:D012170 NCI:C34981 SNOMEDCT_US_2016_03_01:46085004 UMLS_CUI:C0035328 Occlusion, of retinal vein Retinal vein occlusion disease_ontology DOID:1727 retinal vein occlusion DOID:1729 ICD10CM:H34 ICD10CM:H34.9 ICD9CM:362.3 ICD9CM:362.30 NCI:C34980 SNOMEDCT_US_2016_03_01:155111000 SNOMEDCT_US_2016_03_01:193373007 SNOMEDCT_US_2016_03_01:193380009 SNOMEDCT_US_2016_03_01:267717005 SNOMEDCT_US_2016_03_01:73757007 UMLS_CUI:C0035326 Retinal vasc. occlusion Retinal vascular Occlusion Retinal vascular occlusion (disorder) Retinal vascular occlusion NOS (disorder) Retinal vascular occlusion, unspecified Unspecified retinal vascular occlusion (disorder) disease_ontology DOID:1729 retinal vascular occlusion DOID:1731 A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains. DOID:351 ICD10CM:B39 ICD10CM:B39.9 ICD9CM:115 ICD9CM:115.9 MESH:C538362 MESH:D006660 NCI:C34977 NCI:C77201 SNOMEDCT_US_2016_03_01:12962009 SNOMEDCT_US_2016_03_01:154408001 SNOMEDCT_US_2016_03_01:187055002 SNOMEDCT_US_2016_03_01:187056001 SNOMEDCT_US_2016_03_01:187063001 SNOMEDCT_US_2016_03_01:187482000 SNOMEDCT_US_2016_03_01:266218008 UMLS_CUI:C0019655 UMLS_CUI:C0035288 disease_ontology DOID:1731 histoplasmosis DOID:1742 ICD9CM:292.1 MESH:D011605 SNOMEDCT_US_2016_03_01:154855001 SNOMEDCT_US_2016_03_01:191483003 SNOMEDCT_US_2016_03_01:191498001 UMLS_CUI:C0033937 Drug-induced psychosis Drug-induced psychotic disorder disease_ontology DOID:1742 drug psychosis DOID:1749 A carcinoma that derives_from squamous epithelial cells. DOID:5512 EFO:0000707 MESH:D002294 MESH:D018307 NCI:C2929 SNOMEDCT_US_2016_03_01:154605007 SNOMEDCT_US_2016_03_01:189566008 SNOMEDCT_US_2016_03_01:28899001 SNOMEDCT_US_2016_03_01:402815007 UMLS_CUI:C0007137 UMLS_CUI:C0751688 epidermoid carcinoma malignant squamous cell tumor squamous carcinoma squamous cell Epithelioma squamous cell cancer squamous cell carcinoma (disorder) squamous cell carcinoma (morphologic abnormality) squamous cell carcinoma NOS (morphologic abnormality) disease_ontology DOID:1749 squamous cell carcinoma DOID:1752 An ocular cancer that has_material_basis_in melanocytes and is located_in the eye. eye melanoma intraocular melanoma melanoma of eye disease_ontology DOID:1752 ocular melanoma DOID:1754 A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart. MESH:D008946 NCI:C50654 SNOMEDCT_US_2016_03_01:155277002 SNOMEDCT_US_2016_03_01:194725005 SNOMEDCT_US_2016_03_01:79619009 UMLS_CUI:C0026269 Mitral stenosis disease_ontology DOID:1754 mitral valve stenosis DOID:1756 ICD10CM:G51 ICD10CM:G51.9 ICD9CM:351 ICD9CM:351.9 MESH:D005155 NCI:C27594 SNOMEDCT_US_2016_03_01:155069009 SNOMEDCT_US_2016_03_01:155071009 SNOMEDCT_US_2016_03_01:193097005 SNOMEDCT_US_2016_03_01:230543003 SNOMEDCT_US_2016_03_01:267704007 SNOMEDCT_US_2016_03_01:422426003 SNOMEDCT_US_2016_03_01:90039006 UMLS_CUI:C0015464 disease_ontology DOID:1756 facial nerve disease DOID:176 An organ system cancer that located_in the heart and blood vessels. NCI:C4784 UMLS_CUI:C0497243 Cardiovascular tumors cardiovascular neoplasm disease_ontology DOID:176 cardiovascular cancer DOID:1766 A disease of mental health where symptoms are deliberately produced, feigned or exaggerated in order to falsely demonstrate the presence of an illness. ICD10CM:F68.11 ICD9CM:300.16 SNOMEDCT_US_2016_03_01:31122002 SNOMEDCT_US_2016_03_01:430751001 UMLS_CUI:C0015481 Munchausen syndrome disease_ontology DOID:1766 factitious disorder DOID:1770 ICD10CM:K59.3 MESH:D008532 SNOMEDCT_US_2016_03_01:28536002 UMLS_CUI:C0025162 disease_ontology DOID:1770 toxic megacolon DOID:178 A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. DOID:0000405 DOID:2403 DOID:2869 DOID:324 DOID:325 DOID:45 ICD10CM:I72.9 ICD9CM:442.9 MESH:D000783 MESH:D014652 MESH:D020758 MESH:D020760 NCI:C26693 NCI:C35117 SNOMEDCT_US_2016_03_01:134342004 SNOMEDCT_US_2016_03_01:155425005 SNOMEDCT_US_2016_03_01:155428007 SNOMEDCT_US_2016_03_01:195292009 SNOMEDCT_US_2016_03_01:27550009 SNOMEDCT_US_2016_03_01:362727005 SNOMEDCT_US_2016_03_01:371029002 SNOMEDCT_US_2016_03_01:432119003 SNOMEDCT_US_2016_03_01:85659009 UMLS_CUI:C0002940 UMLS_CUI:C0042373 UMLS_CUI:C0752127 UMLS_CUI:C0752130 vascular tissue disease disease_ontology DOID:178 vascular disease DOID:1781 An endocrine gland cancer located_in the thryoid gland located in the neck below the thyroid cartilage. DOID:10008 ICD10CM:C73 ICD9CM:193 KEGG:05216 MESH:D013964 NCI:C3414 NCI:C7510 SNOMEDCT_US_2016_03_01:127018007 SNOMEDCT_US_2016_03_01:154554008 SNOMEDCT_US_2016_03_01:363478007 SNOMEDCT_US_2016_03_01:94098005 UMLS_CUI:C0007115 UMLS_CUI:C0040136 Thyroid gland neoplasm malignant neoplasm of thyroid gland malignant tumour of thyroid gland neoplasm of thyroid gland thyroid neoplasm disease_ontology DOID:1781 thyroid cancer DOID:1785 An endocrine gland cancer located_in the pituitary gland located at the base of the brain. DOID:5671 ICD10CM:C75.1 MESH:D010911 NCI:C3330 NCI:C4769 SNOMEDCT_US_2016_03_01:127024001 SNOMEDCT_US_2016_03_01:363482009 SNOMEDCT_US_2016_03_01:93964007 UMLS_CUI:C0032019 UMLS_CUI:C0496842 Pituitary gland neoplasm malignant Pituitary neoplasm malignant tumor of pituitary gland (disorder) neoplasm of pituitary gland (disorder) pituitary gland cancer pituitary neoplasm disease_ontology DOID:1785 pituitary cancer DOID:1786 MESH:D000314 NCI:C2860 SNOMEDCT_US_2016_03_01:54292009 UMLS_CUI:C0001630 Adrenal Rest neoplasm disease_ontology DOID:1786 adrenal rest tumor DOID:1787 A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain. MESH:D010493 NCI:C34915 SNOMEDCT_US_2016_03_01:3238004 UMLS_CUI:C0031046 disease_ontology DOID:1787 pericarditis DOID:1790 A cell type cancer that has_material_basis_in mesothelial tissue. DOID:4487 DOID:6965 DOID:7434 MESH:C562839 NCI:C27926 NCI:C4456 NCI:C7865 NCI:C8420 OMIM:156240 SNOMEDCT_US_2016_03_01:62064005 UMLS_CUI:C0278752 UMLS_CUI:C0345967 UMLS_CUI:C0392400 UMLS_CUI:C1332338 Diffuse malignant Mesothelioma advanced malignant mesothelioma asbestos-related malignant mesothelioma malignant tumor of Mesothelium disease_ontology DOID:1790 OMIM mapping confirmed by DO. [SN]. malignant mesothelioma DOID:1793 An endocrine gland cancer located_in the pancreas. DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 OMIM:606856 OMIM:613347 OMIM:613348 OMIM:614320 ORDO:1333 ORDO:217074 SNOMEDCT_US_2016_03_01:126859007 SNOMEDCT_US_2016_03_01:154476001 SNOMEDCT_US_2016_03_01:154477005 SNOMEDCT_US_2016_03_01:154478000 SNOMEDCT_US_2016_03_01:187791002 SNOMEDCT_US_2016_03_01:187792009 SNOMEDCT_US_2016_03_01:187796007 SNOMEDCT_US_2016_03_01:269553001 SNOMEDCT_US_2016_03_01:269554007 SNOMEDCT_US_2016_03_01:269555008 SNOMEDCT_US_2016_03_01:363419009 SNOMEDCT_US_2016_03_01:93715005 SNOMEDCT_US_2016_03_01:93823001 SNOMEDCT_US_2016_03_01:94082003 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463 Ca body of pancreas Ca head of pancreas Ca tail of pancreas malignant neoplasm of body of pancreas malignant neoplasm of head of pancreas malignant neoplasm of tail of pancreas pancreas neoplasm pancreatic neoplasm pancreatic tumor disease_ontology DOID:1793 Xref MGI. pancreatic cancer DOID:1799 A pancreatic cancer that is located_in the pancreatic islet cells. DOID:10165 ICD10CM:C25.4 ICD10CM:D13.7 MESH:D007516 NCI:C27031 SNOMEDCT_US_2016_03_01:126864006 SNOMEDCT_US_2016_03_01:128878003 SNOMEDCT_US_2016_03_01:154609001 SNOMEDCT_US_2016_03_01:188855000 SNOMEDCT_US_2016_03_01:237596009 SNOMEDCT_US_2016_03_01:254611009 SNOMEDCT_US_2016_03_01:261713004 SNOMEDCT_US_2016_03_01:269636003 SNOMEDCT_US_2016_03_01:399528006 SNOMEDCT_US_2016_03_01:76345009 UMLS_CUI:C0242363 UMLS_CUI:C0496784 Islet cell neoplasm Islet cell tumor Islet cell tumour endocrine pancreas cancer malignant pancreatic Endocrine tumor malignant tumor of endocrine pancreas (disorder) pancreatic Endocrine neoplasm disease_ontology DOID:1799 islet cell tumor DOID:18 A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra. DOID:579 NCI:C27599 UMLS_CUI:C1335051 Non-neoplastic urinary tract disease urinary tract disease disease_ontology DOID:18 urinary system disease DOID:1800 A carcinoma that derives_from neuroendocrine cells. MESH:D018278 NCI:C3773 SNOMEDCT_US_2016_03_01:253000007 SNOMEDCT_US_2016_03_01:55937004 UMLS_CUI:C0206695 disease_ontology DOID:1800 neuroendocrine carcinoma DOID:1802 ICD9CM:355.9 SNOMEDCT_US_2016_03_01:193155002 SNOMEDCT_US_2016_03_01:267600005 SNOMEDCT_US_2016_03_01:32595002 UMLS_CUI:C0235880 disease_ontology DOID:1802 mononeuritis DOID:1803 MESH:D009443 NCI:C116381 SNOMEDCT_US_2016_03_01:123254001 SNOMEDCT_US_2016_03_01:128192007 SNOMEDCT_US_2016_03_01:203116001 SNOMEDCT_US_2016_03_01:247378004 SNOMEDCT_US_2016_03_01:84299009 UMLS_CUI:C0027813 peripheral neuritis disease_ontology DOID:1803 neuritis DOID:1811 ICD10CM:G90.5 ICD10CM:M89.0 ICD9CM:337.2 ICD9CM:337.20 ICD9CM:337.21 MESH:D012019 NCI:C85042 OMIM:604335 SNOMEDCT_US_2016_03_01:128079007 SNOMEDCT_US_2016_03_01:156849009 SNOMEDCT_US_2016_03_01:15743005 SNOMEDCT_US_2016_03_01:192921009 SNOMEDCT_US_2016_03_01:203490000 SNOMEDCT_US_2016_03_01:203492008 SNOMEDCT_US_2016_03_01:2103002 SNOMEDCT_US_2016_03_01:393605009 SNOMEDCT_US_2016_03_01:403604006 SNOMEDCT_US_2016_03_01:50642008 UMLS_CUI:C0034931 disease_ontology DOID:1811 OMIM mapping confirmed by DO. [SN]. reflex sympathetic dystrophy DOID:182 A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue. MESH:D002114 NCI:C3672 SNOMEDCT_US_2016_03_01:190863003 SNOMEDCT_US_2016_03_01:237881004 SNOMEDCT_US_2016_03_01:6595006 UMLS_CUI:C0006663 Pathologically calcified structure pathologic calcification disease_ontology DOID:182 calcinosis DOID:1824 MESH:D013226 NCI:C85079 SNOMEDCT_US_2016_03_01:13973009 SNOMEDCT_US_2016_03_01:155039002 SNOMEDCT_US_2016_03_01:192998006 SNOMEDCT_US_2016_03_01:193019007 SNOMEDCT_US_2016_03_01:194499008 SNOMEDCT_US_2016_03_01:230456007 UMLS_CUI:C0038220 (Grand mal status) or (status epilepticus) disease_ontology DOID:1824 status epilepticus DOID:1825 A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years. ICD10CM:G40.A MESH:D004832 NCI:C3023 NCI:C50436 SNOMEDCT_US_2016_03_01:140805008 SNOMEDCT_US_2016_03_01:155037000 SNOMEDCT_US_2016_03_01:163596002 SNOMEDCT_US_2016_03_01:16757004 SNOMEDCT_US_2016_03_01:192980007 SNOMEDCT_US_2016_03_01:192983009 SNOMEDCT_US_2016_03_01:230413002 SNOMEDCT_US_2016_03_01:432241000124101 SNOMEDCT_US_2016_03_01:50866000 SNOMEDCT_US_2016_03_01:79631006 UMLS_CUI:C0014553 petit mal seizure pyknolepsy disease_ontology absence seizure DOID:1825 childhood absence epilepsy DOID:1826 A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. EFO:0000474 ICD10CM:G40.9 ICD10CM:G40.909 ICD9CM:345.9 MESH:D004827 NCI:C3020 SNOMEDCT_US_2016_03_01:128613002 SNOMEDCT_US_2016_03_01:155036009 SNOMEDCT_US_2016_03_01:155045005 SNOMEDCT_US_2016_03_01:193026007 SNOMEDCT_US_2016_03_01:246545002 SNOMEDCT_US_2016_03_01:267593008 SNOMEDCT_US_2016_03_01:267698007 SNOMEDCT_US_2016_03_01:271788002 SNOMEDCT_US_2016_03_01:313307000 SNOMEDCT_US_2016_03_01:84757009 UMLS_CUI:C0014544 epilepsy syndrome epileptic syndrome disease_ontology DOID:1826 epilepsy DOID:1827 An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain. MESH:D004829 NCI:C3021 OMIM:600669 OMIM:604827 OMIM:606972 OMIM:607628 OMIM:607682 OMIM:608762 OMIM:609750 OMIM:611136 OMIM:611934 OMIM:612899 OMIM:613060 OMIM:614847 SNOMEDCT_US_2016_03_01:155038005 SNOMEDCT_US_2016_03_01:155043003 SNOMEDCT_US_2016_03_01:192989008 SNOMEDCT_US_2016_03_01:192994008 SNOMEDCT_US_2016_03_01:19598007 UMLS_CUI:C0014548 Generalised epilepsy disease_ontology DOID:1827 Xref MGI. idiopathic generalized epilepsy DOID:1829 ICD9CM:598.8 UMLS_CUI:C0029752 disease_ontology DOID:1829 urethral stricture DOID:1838 MESH:D007706 NCI:C75486 OMIM:309400 SNOMEDCT_US_2016_03_01:59178007 UMLS_CUI:C0022716 COPPER TRANSPORT DISEASE Menkes kinky-hair syndrome steely hair syndrome disease_ontology DOID:1838 OMIM mapping confirmed by DO. [SN]. Menkes disease DOID:184 A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue. DOID:3348 CSP:2019-1041 MESH:D001859 NCI:C9343 SNOMEDCT_US_2016_03_01:115239009 SNOMEDCT_US_2016_03_01:126537000 SNOMEDCT_US_2016_03_01:240201007 UMLS_CUI:C0005967 CA - bone cancer bone neoplasm bone tumour malignant bone neoplasm malignant bone tumour malignant neoplasm of bone malignant osseous tumor neoplasm of bone osseous tumor disease_ontology DOID:184 bone cancer DOID:1849 A drug dependence that involves the continued use of cannabis despite problems related to use of the substance. ICD10CM:F12.2 ICD9CM:304.3 MESH:D002189 NCI:C34445 SNOMEDCT_US_2016_03_01:191835009 SNOMEDCT_US_2016_03_01:191836005 SNOMEDCT_US_2016_03_01:268766005 SNOMEDCT_US_2016_03_01:85005007 UMLS_CUI:C0006870 disease_ontology DOID:1849 cannabis dependence DOID:1852 MESH:D002780 NCI:C84400 OMIM:147480 OMIM:211600 OMIM:243300 OMIM:601847 OMIM:602347 OMIM:605479 OMIM:614972 OMIM:615878 ORDO:172 ORDO:65682 ORDO:69665 SNOMEDCT_US_2016_03_01:4637005 UMLS_CUI:C0008372 intrahepatic cholestasis of pregnancy disease_ontology DOID:1852 Xref MGI. intrahepatic cholestasis DOID:1856 ICD10CM:M27.8 MESH:D002636 NCI:C84630 OMIM:118400 SNOMEDCT_US_2016_03_01:53432004 SNOMEDCT_US_2016_03_01:76098004 UMLS_CUI:C0008029 disease_ontology DOID:1856 OMIM mapping confirmed by DO. [SN]. cherubism DOID:1858 An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. It has material basis in mutations in the GNAS1 gene. DOID:11345 ICD10CM:Q78.1 ICD9CM:756.54 MESH:D005357 MESH:D005359 NCI:C34610 OMIM:174800 SNOMEDCT_US_2016_03_01:10623005 SNOMEDCT_US_2016_03_01:205508003 SNOMEDCT_US_2016_03_01:36517007 UMLS_CUI:C0016063 UMLS_CUI:C0016065 fibrous Dysplasia of bone fibrous dysplasia of bone (disorder) osteitis fibrosa disseminata polyostotic fibrous dysplasia disease_ontology DOID:1858 OMIM mapping confirmed by DO. [SN]. McCune Albright syndrome DOID:1866 ICD10CM:M27.1 ICD9CM:526.3 MESH:D006101 SNOMEDCT_US_2016_03_01:15350006 UMLS_CUI:C0162375 central giant cell (reparative) granuloma central giant cell granuloma central giant cell reparative granuloma of jaw (disorder) disease_ontology DOID:1866 giant cell reparative granuloma DOID:1875 EFO:0004234 Sexual impotence (finding) erectile dysfunction disease_ontology DOID:1875 impotence DOID:1876 ICD10CM:F52.9 ICD10CM:R37 MESH:D012735 NCI:C3347 SNOMEDCT_US_2016_03_01:225723003 SNOMEDCT_US_2016_03_01:231532002 SNOMEDCT_US_2016_03_01:39894007 SNOMEDCT_US_2016_03_01:56925008 SNOMEDCT_US_2016_03_01:65655009 UMLS_CUI:C0549622 disease_ontology DOID:1876 sexual dysfunction DOID:1883 A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. DOID:12430 DOID:12432 DOID:2049 EFO:0003047 ICD10CM:B19.2 ICD10CM:B19.20 ICD9CM:070.7 MESH:D006526 MESH:D019698 NCI:C3098 SNOMEDCT_US_2016_03_01:123324009 SNOMEDCT_US_2016_03_01:154349000 SNOMEDCT_US_2016_03_01:186634008 SNOMEDCT_US_2016_03_01:186643004 SNOMEDCT_US_2016_03_01:50711007 UMLS_CUI:C0019196 NANBH Viral hepatitis C chronic hepatitis C hepatitis C infection hepatitis nonA nonB disease_ontology DOID:1883 hepatitis C DOID:1891 A cranial nerve disease that is located_in the optic nerve. MESH:D009901 NCI:C79698 SNOMEDCT_US_2016_03_01:194037001 SNOMEDCT_US_2016_03_01:267741008 SNOMEDCT_US_2016_03_01:77157004 UMLS_CUI:C0029132 disorder of the second nerve optic nerve disorder optic neuropathy disease_ontology DOID:1891 optic nerve disease DOID:1909 A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. EFO:0000756 KEGG:05218 MESH:D008545 NCI:C3224 OMIM:155600 SNOMEDCT_US_2016_03_01:154501005 SNOMEDCT_US_2016_03_01:189749008 SNOMEDCT_US_2016_03_01:2092003 SNOMEDCT_US_2016_03_01:269503007 SNOMEDCT_US_2016_03_01:269577007 SNOMEDCT_US_2016_03_01:372244006 UMLS_CUI:C0025202 Naevocarcinoma malignant melanoma disease_ontology DOID:1909 melanoma DOID:1919 ICD10CM:E79.1 MESH:D007926 NCI:C61255 OMIM:300322 SNOMEDCT_US_2016_03_01:10406007 SNOMEDCT_US_2016_03_01:124275001 SNOMEDCT_US_2016_03_01:190917005 SNOMEDCT_US_2016_03_01:190918000 SNOMEDCT_US_2016_03_01:190921003 SNOMEDCT_US_2016_03_01:267451005 SNOMEDCT_US_2016_03_01:68655008 SNOMEDCT_US_2016_03_01:90924007 UMLS_CUI:C0023374 Complete hypoxanthine-guanine phosphoribosyltransferase deficiency HG-PRT deficiency Hypoxanthine-guanine phosphoribosyltransferase deficiency (disorder) Hypoxanthine-guanine phosphoribosyltransferase deficiency (disorder) [Ambiguous] Hypoxanthine-guanine-phosphoribosyltransferase deficiency (& [Lesch - Nyhan syndrome]) Lesch - Nyhan syndrome Lesch-Nyhan syndrome (disorder) X-linked hyperuricemia (disorder) [Ambiguous] deficiency of IMP pyrophosphorylase hypoxanthine guanine phosphoribosyltransferase deficiency disease_ontology DOID:1919 OMIM mapping confirmed by DO. [SN]. Lesch-Nyhan syndrome DOID:192 A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary and testis. DOID:12293 MESH:D018312 NCI:C3794 NCI:C39948 SNOMEDCT_US_2016_03_01:115221000 SNOMEDCT_US_2016_03_01:134323003 SNOMEDCT_US_2016_03_01:189724009 SNOMEDCT_US_2016_03_01:189741006 SNOMEDCT_US_2016_03_01:253028001 SNOMEDCT_US_2016_03_01:71440001 UMLS_CUI:C0206724 UMLS_CUI:C1515289 Sex Cord-Stromal neoplasm Sex Cord-Stromal tumor Sex cord stromal tumour Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality) Specialized gonadal neoplasm (morphologic abnormality) Specialized gonadal neoplasm NOS (morphologic abnormality) Specialized gonadal tumor (qualifier value) malignant testicular sex cord-stromal tumor disease_ontology DOID:192 sex cord-gonadal stromal tumor DOID:1920 An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood. MESH:D033461 NCI:C3961 SNOMEDCT_US_2016_03_01:144021008 SNOMEDCT_US_2016_03_01:166733000 SNOMEDCT_US_2016_03_01:237857006 SNOMEDCT_US_2016_03_01:271198001 SNOMEDCT_US_2016_03_01:35885006 UMLS_CUI:C0740394 (Blood urate raized) or (hyperuricemia) uricacidemia disease_ontology DOID:1920 hyperuricemia DOID:1921 ICD10CM:Q98.0 ICD10CM:Q98.4 ICD9CM:758.7 MESH:D007713 NCI:C34752 SNOMEDCT_US_2016_03_01:157021007 SNOMEDCT_US_2016_03_01:205696000 SNOMEDCT_US_2016_03_01:205701007 SNOMEDCT_US_2016_03_01:205712007 SNOMEDCT_US_2016_03_01:22053006 SNOMEDCT_US_2016_03_01:268357008 SNOMEDCT_US_2016_03_01:405769009 SNOMEDCT_US_2016_03_01:405770005 UMLS_CUI:C0022735 Hypogonadotropic Hypogonadism Klinefelter syndrome XXY syndrome XXY trisomy disease_ontology DOID:1921 No OMIM mapping, confirmed by DO. [LS]. Klinefelter's syndrome DOID:1923 MESH:D012734 UMLS_CUI:C0036875 disorder of sexual differentiation (disorder) sex differentiation disorder disease_ontology DOID:1923 sex differentiation disease DOID:1924 A gonadal disease that is characterized by diminished functional activity of the gonads. MESH:D007006 NCI:C9227 OMIM:241100 OMIM:307300 SNOMEDCT_US_2016_03_01:48130008 UMLS_CUI:C0020619 disease_ontology DOID:1924 hypogonadism DOID:1926 A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver. ICD10CM:E75.22 MESH:D005776 NCI:C61268 OMIM:230800 OMIM:230900 OMIM:231000 OMIM:608013 OMIM:610539 ORDO:355 SNOMEDCT_US_2016_03_01:180485001 SNOMEDCT_US_2016_03_01:190794006 SNOMEDCT_US_2016_03_01:2859005 SNOMEDCT_US_2016_03_01:62201009 UMLS_CUI:C0017205 Gaucher disease acid beta-glucosidase deficiency glocucerebrosidase deficiency glucosylceramide beta-glucosidase deficiency kerasin thesaurismosis lipoid histiocytosis (kerasin type) disease_ontology DOID:1926 Xref MGI. OMIM mapping confirmed by DO. [SN]. Gaucher's disease DOID:1927 ICD10CM:E75.3 MESH:D013106 NCI:C117254 SNOMEDCT_US_2016_03_01:238028008 SNOMEDCT_US_2016_03_01:58459009 UMLS_CUI:C0037899 Sphingolipidosis (disorder) Sphingolipidosis, NOS sphingolipidoses disease_ontology DOID:1927 sphingolipidosis DOID:1928 MESH:D018980 NCI:C85232 OMIM:194050 SNOMEDCT_US_2016_03_01:63247009 UMLS_CUI:C0175702 Fanconi Schlesinger syndrome disease_ontology DOID:1928 OMIM mapping confirmed by DO. [LS]. Williams-Beuren syndrome DOID:193 An organ system cancer that is manifested in the reproductive organs. DOID:1900 NCI:C3674 UMLS_CUI:C0178830 Reproductive tumor malignant reproductive system neoplasm disease_ontology cancer of reproductive system DOID:193 reproductive organ cancer DOID:1932 ICD10CM:Q93.5 MESH:D017204 NCI:C75462 OMIM:105830 SNOMEDCT_US_2016_03_01:76880004 UMLS_CUI:C0162635 happy puppet syndrome puppetlike syndrome disease_ontology DOID:1932 OMIM mapping confirmed by DO. [SN]. Angelman syndrome DOID:1934 A bone development disease that results_in defective ossification of located_in bone. MESH:D004413 NCI:C34560 SNOMEDCT_US_2016_03_01:109420003 UMLS_CUI:C0013393 disease_ontology DOID:1934 dysostosis DOID:1936 EFO:0003914 ICD10CM:I25.1 ICD10CM:I70 ICD9CM:440 MESH:D050197 NCI:C35768 NCI:C35771 SNOMEDCT_US_2016_03_01:155382007 SNOMEDCT_US_2016_03_01:155414001 SNOMEDCT_US_2016_03_01:194848007 SNOMEDCT_US_2016_03_01:195251000 SNOMEDCT_US_2016_03_01:266318005 SNOMEDCT_US_2016_03_01:38716007 UMLS_CUI:C0004153 disease_ontology DOID:1936 atherosclerosis DOID:1943 ICD10CM:L65.0 ICD9CM:704.02 NCI:C112200 SNOMEDCT_US_2016_03_01:201147004 SNOMEDCT_US_2016_03_01:39479004 UMLS_CUI:C0263518 Telogen effluvium (disorder) disease_ontology DOID:1943 telogen effluvium DOID:1947 A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively. DOID:10996 ICD10CM:A59 ICD10CM:A59.9 ICD9CM:131 ICD9CM:131.9 MESH:D014245 NCI:C35720 SNOMEDCT_US_2016_03_01:105648001 SNOMEDCT_US_2016_03_01:187206001 SNOMEDCT_US_2016_03_01:187364002 SNOMEDCT_US_2016_03_01:56335008 UMLS_CUI:C0040921 disease_ontology trichomonas infection DOID:1947 trichomoniasis DOID:1962 MESH:D005184 NCI:C26771 SNOMEDCT_US_2016_03_01:128134005 UMLS_CUI:C0015556 disease_ontology DOID:1962 fallopian tube disease DOID:1967 A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis. MESH:D007890 NCI:C3158 SNOMEDCT_US_2016_03_01:189790006 SNOMEDCT_US_2016_03_01:443719001 SNOMEDCT_US_2016_03_01:51549004 UMLS_CUI:C0023269 Leiomyosarcomas disease_ontology DOID:1967 leiomyosarcoma DOID:1969 A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance. DOID:1968 CSP:0723-4729 ICD10CM:G80 ICD10CM:G80.9 ICD9CM:343.8 MESH:D002547 NCI:C34460 SNOMEDCT_US_2016_03_01:1178005 SNOMEDCT_US_2016_03_01:128188000 SNOMEDCT_US_2016_03_01:155024003 SNOMEDCT_US_2016_03_01:267696006 SNOMEDCT_US_2016_03_01:270488006 UMLS_CUI:C0007789 UMLS_CUI:C0029806 infantile cerebral palsy disease_ontology DOID:1969 cerebral palsy DOID:1984 MESH:D012004 NCI:C3350 SNOMEDCT_US_2016_03_01:126847008 UMLS_CUI:C0034885 Rectal tumor neoplasm of rectum (disorder) rectum neoplasm disease_ontology DOID:1984 rectal neoplasm DOID:1993 A colorectal cancer that is located_in the rectum. DOID:1989 ICD10CM:C20 ICD9CM:154.1 MESH:D012004 NCI:C7418 NCI:C9382 SNOMEDCT_US_2016_03_01:154466004 SNOMEDCT_US_2016_03_01:187761007 SNOMEDCT_US_2016_03_01:254582000 SNOMEDCT_US_2016_03_01:269545009 SNOMEDCT_US_2016_03_01:363351006 SNOMEDCT_US_2016_03_01:93984006 UMLS_CUI:C0007113 UMLS_CUI:C0949022 carcinoma of rectum carcinoma of the rectum malignant Rectal tumor malignant neoplasm of rectum malignant rectum tumor malignant tumor of rectum (disorder) rectal cancer disease_ontology cancer of rectum DOID:1993 rectum cancer DOID:1996 A rectum cancer that derives_from epithelial cells of glandular origin. NCI:C9383 SNOMEDCT_US_2016_03_01:254582000 UMLS_CUI:C0149978 Rectal adenocarcinoma adenocarcinoma of rectum (disorder) disease_ontology adenocarcinoma of rectum DOID:1996 rectum adenocarcinoma DOID:200 MESH:D005870 NCI:C3055 NCI:C7069 SNOMEDCT_US_2016_03_01:115238001 SNOMEDCT_US_2016_03_01:134300001 SNOMEDCT_US_2016_03_01:189890001 SNOMEDCT_US_2016_03_01:189893004 SNOMEDCT_US_2016_03_01:443790001 UMLS_CUI:C0017525 Giant cell neoplasm Giant cell tumor (morphologic abnormality) Giant cell tumor (qualifier value) Giant cell tumor NOS (morphologic abnormality) Giant cell tumors (morphologic abnormality) tumor of the Giant cell disease_ontology Giant cell tumors DOID:200 giant cell tumor DOID:2001 A nervous system benign neoplasm that is characterized as a nerve tissue tumor. MESH:D009463 NCI:C3275 SNOMEDCT_US_2016_03_01:154622009 SNOMEDCT_US_2016_03_01:189950003 SNOMEDCT_US_2016_03_01:25169009 SNOMEDCT_US_2016_03_01:274089002 SNOMEDCT_US_2016_03_01:443892003 UMLS_CUI:C0027858 disease_ontology DOID:2001 neuroma DOID:2006 ICD9CM:362.56 MESH:D019773 SNOMEDCT_US_2016_03_01:133853005 SNOMEDCT_US_2016_03_01:193391002 SNOMEDCT_US_2016_03_01:367649002 SNOMEDCT_US_2016_03_01:53428005 SNOMEDCT_US_2016_03_01:55991001 UMLS_CUI:C0339543 Macular puckering of retina Macular retinal puckering cellophane maculopathy disease_ontology DOID:2006 preretinal fibrosis DOID:2007 ICD10CM:H35.3 ICD9CM:362.5 SNOMEDCT_US_2016_03_01:193384000 SNOMEDCT_US_2016_03_01:193392009 SNOMEDCT_US_2016_03_01:267611002 UMLS_CUI:C0339436 degeneration of macula and posterior pole of retina degeneration of macula or posterior pole disease_ontology DOID:2007 degeneration of macula and posterior pole DOID:201 A musculoskeletal system cancer that is located_in connective tissue. MESH:D009372 SNOMEDCT_US_2016_03_01:126598008 SNOMEDCT_US_2016_03_01:254821003 UMLS_CUI:C0027656 Tumour of connective tissue connective tissue neoplasm neoplasm of connective tissues disease_ontology DOID:201 connective tissue cancer DOID:2018 ICD10CM:E16.1 MESH:D006946 NCI:C113104 SNOMEDCT_US_2016_03_01:124860004 SNOMEDCT_US_2016_03_01:131103005 SNOMEDCT_US_2016_03_01:154694003 SNOMEDCT_US_2016_03_01:267477002 SNOMEDCT_US_2016_03_01:83469008 UMLS_CUI:C0020459 hyperinsulinemia disease_ontology DOID:2018 hyperinsulinism DOID:2021 DOID:2023 ICD10CM:C58 ICD9CM:181 NCI:C3555 SNOMEDCT_US_2016_03_01:188187004 SNOMEDCT_US_2016_03_01:449421003 UMLS_CUI:C0153572 Placental tumors malignant Placental tumor malignant neoplasm of placenta neoplasm of placenta (disorder) placental cancer primary malignant neoplasm of placenta disease_ontology DOID:2021 placenta cancer DOID:2024 NCI:C8893 SNOMEDCT_US_2016_03_01:448401007 UMLS_CUI:C0855173 Choriocarcinoma of the Placenta disease_ontology DOID:2024 placental choriocarcinoma DOID:2025 NCI:C4646 SNOMEDCT_US_2016_03_01:1884006 SNOMEDCT_US_2016_03_01:417057000 SNOMEDCT_US_2016_03_01:417570003 UMLS_CUI:C0349557 Gestational choriocarcinoma (morphologic abnormality) Gestational chorionepithelioma Molar pregnancy with choriocarcinoma (disorder) disease_ontology DOID:2025 gestational choriocarcinoma DOID:203 A hyperostosis that involves formation of new bone on the surface of preexisting bone. ICD10CM:M27.8 ICD9CM:726.91 MESH:D005096 NCI:C3029 SNOMEDCT_US_2016_03_01:156665008 SNOMEDCT_US_2016_03_01:202894007 SNOMEDCT_US_2016_03_01:267997004 SNOMEDCT_US_2016_03_01:268091003 SNOMEDCT_US_2016_03_01:416189003 SNOMEDCT_US_2016_03_01:80400009 UMLS_CUI:C1442903 bone spur bony outgrowth orbital exostosis osteophyte swimmer's exostosis disease_ontology DOID:203 exostosis DOID:2030 A cognitive disorder that involves an excessive, irrational dread of everyday situations. DOID:12884 ICD10CM:F41.9 ICD9CM:300.09 MESH:D001008 NCI:C2878 OMIM:607834 SNOMEDCT_US_2016_03_01:191703000 SNOMEDCT_US_2016_03_01:192405006 SNOMEDCT_US_2016_03_01:197480006 SNOMEDCT_US_2016_03_01:65673007 UMLS_CUI:C0003469 UMLS_CUI:C0154455 anxiety anxiety state disease_ontology DOID:2030 anxiety disorder DOID:2033 A specific developmental disorder that involves specific developmental disorders of speech and language. ICD10CM:F80.9 MESH:D003147 NCI:C2958 SNOMEDCT_US_2016_03_01:278919001 SNOMEDCT_US_2016_03_01:74825008 UMLS_CUI:C0009460 disease_ontology DOID:2033 communication disorder DOID:2034 MESH:D004678 NCI:C98920 SNOMEDCT_US_2016_03_01:58762006 UMLS_CUI:C0014068 disease_ontology DOID:2034 encephalomalacia DOID:204 ICD10CM:M77.9 ICD9CM:726.9 ICD9CM:726.90 MESH:D012216 SNOMEDCT_US_2016_03_01:202890003 SNOMEDCT_US_2016_03_01:23680005 SNOMEDCT_US_2016_03_01:278525009 UMLS_CUI:C0242490 disease_ontology DOID:204 enthesopathy DOID:2043 A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. DOID:12591 DOID:12592 DOID:2042 EFO:0004197 MESH:D006509 MESH:D019694 NCI:C3097 SNOMEDCT_US_2016_03_01:154348008 SNOMEDCT_US_2016_03_01:186625003 SNOMEDCT_US_2016_03_01:266195001 SNOMEDCT_US_2016_03_01:66071002 UMLS_CUI:C0019163 chronic hepatitis B hepatitis B infection disease_ontology Serum hepatitis DOID:2043 hepatitis B DOID:205 A bone remodeling disease that results in an abnormal growth of located_in bone. ICD10CM:M89.3 ICD10CM:M89.30 MESH:D015576 NCI:C34712 SNOMEDCT_US_2016_03_01:13814009 SNOMEDCT_US_2016_03_01:203514008 UMLS_CUI:C0020492 bone hypertrophy hypertrophy of bone hypertrophy of bone (disorder) hypertrophy of bone (morphologic abnormality) disease_ontology DOID:205 hyperostosis DOID:2055 An anxiety disorder which results from a traumatic experience that results in psychological trauma. ICD10CM:F43.1 ICD10CM:F43.10 ICD9CM:309.81 MESH:D013313 NCI:C3389 SNOMEDCT_US_2016_03_01:192415000 SNOMEDCT_US_2016_03_01:47505003 UMLS_CUI:C0038436 traumatic neurosis disease_ontology post-traumatic stress disorder DOID:2055 post-traumatic stress disorder DOID:2064 NCI:C40311 UMLS_CUI:C1520099 disease_ontology DOID:2064 vulvar syringoma DOID:2089 A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces. ICD10CM:K59.0 ICD10CM:K59.00 ICD9CM:564.0 ICD9CM:564.00 MESH:D003248 NCI:C37930 SNOMEDCT_US_2016_03_01:139356000 SNOMEDCT_US_2016_03_01:139358004 SNOMEDCT_US_2016_03_01:139359007 SNOMEDCT_US_2016_03_01:14760008 SNOMEDCT_US_2016_03_01:162080004 SNOMEDCT_US_2016_03_01:162082007 SNOMEDCT_US_2016_03_01:162083002 SNOMEDCT_US_2016_03_01:197123003 SNOMEDCT_US_2016_03_01:363693003 UMLS_CUI:C0009806 disease_ontology DOID:2089 constipation DOID:2095 ICD10CM:C44 NCI:C4810 SNOMEDCT_US_2016_03_01:188083002 SNOMEDCT_US_2016_03_01:255095005 SNOMEDCT_US_2016_03_01:32272007 SNOMEDCT_US_2016_03_01:359719004 UMLS_CUI:C1321904 malignant neoplasm of sweat gland malignant tumor of the Sweat gland disease_ontology DOID:2095 sweat gland cancer DOID:2101 A vulva carcinoma and has_material_basis_in squamous cells and is located_in the epidermis of the vulvar tissue. NCI:C4052 SNOMEDCT_US_2016_03_01:254895003 UMLS_CUI:C0280856 Vulvar Epidermoid carcinoma vulvar squamous cell carcinoma disease_ontology squamous cell carcinoma of vulva DOID:2101 vulva squamous cell carcinoma DOID:2106 A muscle tissue disease that is characterised by slow muscle relaxation associated with hyperexcitation of the muscle fibres. ICD9CM:359.22 MESH:D009224 NCI:C84912 OMIM:160800 OMIM:255700 ORDO:614 UMLS_CUI:C0027127 Congenital myotonia, autosomal dominant form (disorder) Thomsen disease Thomsen's disease disease_ontology DOID:2106 OMIM mapping confirmed by DO. [SN]. myotonia congenita DOID:2115 A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly. DOID:6026 ICD9CM:279.03 SNOMEDCT_US_2016_03_01:190982008 UMLS_CUI:C0154276 B cell (antibody) deficiencies Immunoglobulin heavy chain deficiency (disorder) immunoglobulin heavy chain deletion disease_ontology DOID:2115 B cell deficiency DOID:214 ICD10CM:K03.8 ICD10CM:K03.89 ICD9CM:521.8 ICD9CM:521.89 SNOMEDCT_US_2016_03_01:197505001 UMLS_CUI:C0029770 disease_ontology DOID:214 teeth hard tissue disease DOID:2146 NCI:C8267 SNOMEDCT_US_2016_03_01:423627007 UMLS_CUI:C0280746 sarcoma of Ovary disease_ontology DOID:2146 ovary sarcoma DOID:2151 NCI:C40026 UMLS_CUI:C1518236 disease_ontology DOID:2151 malignant ovarian surface epithelial-stromal neoplasm DOID:2152 An ovarian cancer that is derives_from ovarian surface epithelium. NCI:C4381 SNOMEDCT_US_2016_03_01:237057005 UMLS_CUI:C0341823 Ovarian Surface epithelial-Stromal tumor epithelial tumor of ovary (disorder) disease_ontology epithelial tumor of ovary DOID:2152 ovary epithelial cancer DOID:2154 A kidney cancer that affects the kidneys and typically located_in children. DOID:5177 DOID:5180 MESH:D009396 NCI:C27730 NCI:C3267 NCI:C40407 NCI:C6180 OMIM:194070 SNOMEDCT_US_2016_03_01:25081006 SNOMEDCT_US_2016_03_01:302849000 SNOMEDCT_US_2016_03_01:31470003 UMLS_CUI:C0027708 UMLS_CUI:C1332219 UMLS_CUI:C1333015 adult nephroblastoma adult renal Wilms' tumor childhood renal Wilms' cancer renal Wilms tumor disease_ontology Wilms' tumor childhood renal Wilms tumor DOID:2154 OMIM mapping confirmed by DO. [SN]. nephroblastoma DOID:216 DOID:10785 DOID:10870 DOID:11913 EFO:0003819 ICD10CM:K02 ICD10CM:K02.6 ICD10CM:K02.9 ICD9CM:521.0 ICD9CM:521.00 ICD9CM:521.06 ICD9CM:521.07 MESH:D003731 NCI:C52593 SNOMEDCT_US_2016_03_01:155632007 SNOMEDCT_US_2016_03_01:196307002 SNOMEDCT_US_2016_03_01:80967001 UMLS_CUI:C0011334 UMLS_CUI:C1456144 UMLS_CUI:C1456145 Dental caries extending into pulp Dental caries of smooth surface Dental caries pit and fissure disease_ontology DOID:216 dental caries DOID:2163 DOID:4728 NCI:C27102 SNOMEDCT_US_2016_03_01:195823002 SNOMEDCT_US_2016_03_01:232340005 SNOMEDCT_US_2016_03_01:232359007 UMLS_CUI:C0339820 disease_ontology DOID:2163 nasal cavity disease DOID:217 ICD9CM:521.01 SNOMEDCT_US_2016_03_01:109570002 SNOMEDCT_US_2016_03_01:19437001 SNOMEDCT_US_2016_03_01:196303003 SNOMEDCT_US_2016_03_01:80353004 UMLS_CUI:C0266853 Dental caries limited to enamel primary dental caries simple dental cavity disease_ontology DOID:217 enamel caries DOID:2170 DOID:10769 ICD9CM:616.1 ICD9CM:616.10 MESH:D014627 NCI:C26911 SNOMEDCT_US_2016_03_01:155981006 SNOMEDCT_US_2016_03_01:198212006 SNOMEDCT_US_2016_03_01:198213001 SNOMEDCT_US_2016_03_01:198223005 SNOMEDCT_US_2016_03_01:266655004 SNOMEDCT_US_2016_03_01:30800001 SNOMEDCT_US_2016_03_01:393596009 UMLS_CUI:C0042267 UMLS_CUI:C0042268 disease_ontology DOID:2170 vaginitis DOID:2174 A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye. DOID:9985 ICD9CM:190.8 MESH:D005134 NCI:C3030 SNOMEDCT_US_2016_03_01:126995000 SNOMEDCT_US_2016_03_01:188277006 SNOMEDCT_US_2016_03_01:371486001 UMLS_CUI:C0015414 UMLS_CUI:C0153632 Ocular tumor eye neoplasm malignant eye neoplasm neoplasm of eye neoplasm of eye proper disease_ontology DOID:2174 ocular cancer DOID:2187 A dental enamel hypoplasia characterized by abnormal enamel formation. CSP:0828-0533 ICD10CM:K00.5 MESH:D000567 OMIM:PS104500 ORDO:88661 SNOMEDCT_US_2016_03_01:78494001 UMLS_CUI:C0002452 disease_ontology DOID:2187 Xref MGI. amelogenesis imperfecta DOID:219 A colorectal cancer that is located_in the colon. ICD10CM:C18 ICD10CM:C18.9 ICD9CM:153 ICD9CM:153.9 MESH:D003110 NCI:C9242 SNOMEDCT_US_2016_03_01:154463007 SNOMEDCT_US_2016_03_01:187759003 SNOMEDCT_US_2016_03_01:269461008 SNOMEDCT_US_2016_03_01:269542007 SNOMEDCT_US_2016_03_01:363406005 SNOMEDCT_US_2016_03_01:93761005 UMLS_CUI:C0007102 disease_ontology DOID:219 colon cancer DOID:2213 ICD10CM:D69.9 ICD9CM:287.9 MESH:D006474 SNOMEDCT_US_2016_03_01:191327000 SNOMEDCT_US_2016_03_01:191331006 SNOMEDCT_US_2016_03_01:191437009 SNOMEDCT_US_2016_03_01:268884000 UMLS_CUI:C0019087 Hemorrhagic diathesis Hemorrhagic disease disease_ontology DOID:2213 hemorrhagic disease DOID:2218 MESH:D001791 SNOMEDCT_US_2016_03_01:22716005 UMLS_CUI:C0005818 Thrombocytopathy platelet disorder disease_ontology DOID:2218 blood platelet disease DOID:2224 A myeloproliferative neoplasm that is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage and that results_in the overproduction of platelets. ICD10CM:D47.3 ICD9CM:238.71 MESH:D013920 NCI:C3407 OMIM:187950 OMIM:300331 OMIM:601977 OMIM:614521 ORDO:3318 ORDO:71493 SNOMEDCT_US_2016_03_01:109994006 SNOMEDCT_US_2016_03_01:128844009 SNOMEDCT_US_2016_03_01:189508006 SNOMEDCT_US_2016_03_01:189513005 SNOMEDCT_US_2016_03_01:189514004 SNOMEDCT_US_2016_03_01:191333009 SNOMEDCT_US_2016_03_01:234499005 SNOMEDCT_US_2016_03_01:307652003 SNOMEDCT_US_2016_03_01:65471002 UMLS_CUI:C0040028 Essential thrombocythaemia familial thrombocytosis hemorrhagic thrombocythemia hereditary thrombocythemia primary Thrombocytosis disease_ontology DOID:2224 Xref MGI. OMIM mapping confirmed by DO. [SN]. essential thrombocythemia DOID:2226 A myeloid neoplasm that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood. DOID:6002 ICD10CM:D47.1 NCI:C4345 SNOMEDCT_US_2016_03_01:109993000 SNOMEDCT_US_2016_03_01:115248004 SNOMEDCT_US_2016_03_01:128842008 SNOMEDCT_US_2016_03_01:20921005 UMLS_CUI:C1292778 CMPD CMPD, U chronic myeloproliferative disease disease_ontology DOID:2226 myeloproliferative neoplasm DOID:2234 An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response. MESH:D004828 NCI:C122812 SNOMEDCT_US_2016_03_01:155041001 SNOMEDCT_US_2016_03_01:155044009 SNOMEDCT_US_2016_03_01:193007004 SNOMEDCT_US_2016_03_01:230381009 SNOMEDCT_US_2016_03_01:29753000 SNOMEDCT_US_2016_03_01:67139004 UMLS_CUI:C0014547 localisation-related epilepsy partial epilepsy disease_ontology DOID:2234 focal epilepsy DOID:2237 DOID:12352 DOID:14551 DOID:1706 DOID:1707 DOID:2238 ICD10CM:K73.9 ICD9CM:570 ICD9CM:571.4 ICD9CM:571.40 ICD9CM:571.41 MESH:D006521 NCI:C82978 SNOMEDCT_US_2016_03_01:155808003 SNOMEDCT_US_2016_03_01:155813004 SNOMEDCT_US_2016_03_01:197268000 SNOMEDCT_US_2016_03_01:197278002 SNOMEDCT_US_2016_03_01:197288001 SNOMEDCT_US_2016_03_01:197289009 SNOMEDCT_US_2016_03_01:266536009 SNOMEDCT_US_2016_03_01:266539002 SNOMEDCT_US_2016_03_01:41889008 SNOMEDCT_US_2016_03_01:76783007 UMLS_CUI:C0001308 UMLS_CUI:C0019189 UMLS_CUI:C0149519 acute and subacute liver necrosis acute hepatitis acute/subac. necrosis of liver animal hepatitis chronic hepatitis chronic persistent hepatitis disease_ontology DOID:2237 hepatitis DOID:224 DOID:2315 ICD10CM:G45.9 ICD9CM:435.8 MESH:D002546 NCI:C50781 SNOMEDCT_US_2016_03_01:155404005 SNOMEDCT_US_2016_03_01:195196001 SNOMEDCT_US_2016_03_01:195207009 SNOMEDCT_US_2016_03_01:266257000 SNOMEDCT_US_2016_03_01:266314007 SNOMEDCT_US_2016_03_01:313242003 SNOMEDCT_US_2016_03_01:38609002 UMLS_CUI:C0007787 UMLS_CUI:C0155728 TIA TIA - Transient ischaemic attack TRANSIENT ISCHEMIC ATTACK Transient cerebral ischaemia Transient cerebral ischaemia NOS Transient cerebral ischemia (disorder) [Ambiguous] Transient ischemic attacks (disorder) transient ischemic attack disease_ontology DOID:224 transient cerebral ischemia DOID:2247 An bone structure disease that involves degeneration between vertebra located_in vertebral column. DOID:8708 DOID:8709 DOID:8888 DOID:8905 DOID:9949 ICD10CM:M47 ICD10CM:M47.9 ICD9CM:721.9 MESH:D055009 SNOMEDCT_US_2016_03_01:156622007 SNOMEDCT_US_2016_03_01:156628006 SNOMEDCT_US_2016_03_01:202701004 SNOMEDCT_US_2016_03_01:202704007 SNOMEDCT_US_2016_03_01:267973008 SNOMEDCT_US_2016_03_01:268074002 SNOMEDCT_US_2016_03_01:268075001 SNOMEDCT_US_2016_03_01:8847002 UMLS_CUI:C0038019 Lumbar spondylosis with myelopathy (disorder) Spondylogenic compression of lumbar spinal cord Spondylogenic compression of thoracic spinal cord Spondylosis with myelopathy (disorder) Thoracic or lumbar spondylosis with myelopathy lumbosacral spondylosis without myelopathy spondylosis with myelopathy disease_ontology DOID:2247 spondylosis DOID:225 A disease comprised of a group of signs and symptoms that occur together and characterize a particular abnormality. MESH:D013577 NCI:C28193 SNOMEDCT_US_2016_03_01:64572001 UMLS_CUI:C0039082 disease_ontology DOID:225 syndrome DOID:2256 A bone development disease that results_in defective development of cartilage or bone. DOID:1764 ICD10CM:Q78.9 ICD9CM:756.4 MESH:D010009 NCI:C34466 NCI:C84978 OMIM:215050 SNOMEDCT_US_2016_03_01:105985007 SNOMEDCT_US_2016_03_01:205510001 SNOMEDCT_US_2016_03_01:205539001 SNOMEDCT_US_2016_03_01:240190009 SNOMEDCT_US_2016_03_01:268350005 SNOMEDCT_US_2016_03_01:378007 SNOMEDCT_US_2016_03_01:67988000 UMLS_CUI:C0008449 UMLS_CUI:C0029422 Cartilage Development disorder Congenital anomaly of cartilage (disorder) Osteochondrodysplasia syndrome (disorder) chondrodystrophy disease_ontology DOID:2256 osteochondrodysplasia DOID:227 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself. ICD10CM:M24.6 ICD9CM:718.5 ICD9CM:718.50 MESH:D000844 SNOMEDCT_US_2016_03_01:111227009 SNOMEDCT_US_2016_03_01:156559001 SNOMEDCT_US_2016_03_01:156569007 SNOMEDCT_US_2016_03_01:202297005 SNOMEDCT_US_2016_03_01:202323002 SNOMEDCT_US_2016_03_01:36504009 UMLS_CUI:C0003090 disease_ontology DOID:227 ankylosis DOID:2272 A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge. ICD10CM:B37.3 ICD9CM:112.1 MESH:D002181 NCI:C2914 SNOMEDCT_US_2016_03_01:154404004 SNOMEDCT_US_2016_03_01:187009004 SNOMEDCT_US_2016_03_01:266155003 SNOMEDCT_US_2016_03_01:72605008 UMLS_CUI:C0700345 Candidal vulvovaginitis Candidal vulvovaginitis (disorder) Candidal vulvovaginitis NOS (disorder) Candidal: [vulvovaginitis NOS] or [cervix] Candidiasis of vulva and vagina Monilial vulvovaginitis Vulvovaginal Candidiasis disease_ontology DOID:2272 vulvovaginal candidiasis DOID:2275 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as "sore throat". The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever. DOID:10455 DOID:11586 DOID:11588 DOID:938 DOID:939 ICD10CM:J02 ICD10CM:J02.9 ICD9CM:462 ICD9CM:472 ICD9CM:478.20 MESH:D010608 MESH:D010612 NCI:C26850 NCI:C26851 NCI:C34355 SNOMEDCT_US_2016_03_01:141458004 SNOMEDCT_US_2016_03_01:155502006 SNOMEDCT_US_2016_03_01:155521003 SNOMEDCT_US_2016_03_01:164261009 SNOMEDCT_US_2016_03_01:195654001 SNOMEDCT_US_2016_03_01:195664005 SNOMEDCT_US_2016_03_01:195763009 SNOMEDCT_US_2016_03_01:195784004 SNOMEDCT_US_2016_03_01:195832000 SNOMEDCT_US_2016_03_01:266379007 SNOMEDCT_US_2016_03_01:266383007 SNOMEDCT_US_2016_03_01:27321001 SNOMEDCT_US_2016_03_01:363746003 SNOMEDCT_US_2016_03_01:367427004 SNOMEDCT_US_2016_03_01:37616004 SNOMEDCT_US_2016_03_01:405737000 SNOMEDCT_US_2016_03_01:75860007 UMLS_CUI:C0001344 UMLS_CUI:C0031345 UMLS_CUI:C0031350 UMLS_CUI:C0155824 Inflamed throat Persistent sore throat Pharyngeal disorder Pharyngitis - acute Sore throat - chronic acute pharyngitis acute sore throat chronic pharyn/nasopharyngitis chronic pharyngitis chronic pharyngitis and nasopharyngitis chronic sore throat disease_ontology pharyngeal disease DOID:2275 pharyngitis DOID:2277 An endocrine system disease that is located_in the gonads. MESH:D006058 NCI:C26786 UMLS_CUI:C0018050 disease_ontology DOID:2277 gonadal disease DOID:229 A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes. ICD9CM:629.9 MESH:D005831 SNOMEDCT_US_2016_03_01:156032001 SNOMEDCT_US_2016_03_01:156066005 SNOMEDCT_US_2016_03_01:198486002 SNOMEDCT_US_2016_03_01:244938009 SNOMEDCT_US_2016_03_01:266680004 SNOMEDCT_US_2016_03_01:310789003 SNOMEDCT_US_2016_03_01:38233001 UMLS_CUI:C0017411 disease_ontology DOID:229 female reproductive system disease DOID:2297 A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly. DOID:11348 ICD10CM:A27 ICD10CM:A27.0 ICD10CM:A27.9 ICD9CM:100 ICD9CM:100.0 ICD9CM:100.9 MESH:D007922 MESH:D014895 NCI:C84825 SNOMEDCT_US_2016_03_01:154391003 SNOMEDCT_US_2016_03_01:186953000 SNOMEDCT_US_2016_03_01:186954006 SNOMEDCT_US_2016_03_01:186958009 SNOMEDCT_US_2016_03_01:186959001 SNOMEDCT_US_2016_03_01:187311001 SNOMEDCT_US_2016_03_01:266213004 SNOMEDCT_US_2016_03_01:398067003 SNOMEDCT_US_2016_03_01:398222003 SNOMEDCT_US_2016_03_01:50574007 SNOMEDCT_US_2016_03_01:69092001 SNOMEDCT_US_2016_03_01:77377001 UMLS_CUI:C0023364 UMLS_CUI:C0043102 Fort Bragg fever Leptospirosis icterohaemorrhagica Rat Catcher's Yellows Weil's disease nanukayami fever spirochetal jaundice disease_ontology DOID:2297 leptospirosis DOID:231 A neurodegenerative disease that is located_in the motor neurones. ICD10CM:G12.2 ICD10CM:G12.20 ICD9CM:335.2 MESH:D016472 SNOMEDCT_US_2016_03_01:155015007 SNOMEDCT_US_2016_03_01:192888001 SNOMEDCT_US_2016_03_01:192889009 SNOMEDCT_US_2016_03_01:192890000 SNOMEDCT_US_2016_03_01:37340000 UMLS_CUI:C0085084 disease_ontology DOID:231 motor neuron disease DOID:2316 MESH:D002545 SNOMEDCT_US_2016_03_01:11890005 SNOMEDCT_US_2016_03_01:193049009 SNOMEDCT_US_2016_03_01:389100007 UMLS_CUI:C0007786 Ischaemic encephalopathy Ischemic encephalopathy (disorder) disease_ontology DOID:2316 brain ischemia DOID:2320 MESH:D008173 UMLS_CUI:C0600260 respiratory airway obstruction disease_ontology DOID:2320 obstructive lung disease DOID:2321 ICD10CM:K30 ICD10CM:R10.13 MESH:D004415 NCI:C26756 SNOMEDCT_US_2016_03_01:139299007 SNOMEDCT_US_2016_03_01:155722007 SNOMEDCT_US_2016_03_01:162031009 SNOMEDCT_US_2016_03_01:196752002 SNOMEDCT_US_2016_03_01:249510006 SNOMEDCT_US_2016_03_01:266505001 SNOMEDCT_US_2016_03_01:87548005 UMLS_CUI:C0013395 Dyspepsia, indigestion NOS indigestion disease_ontology DOID:2321 dyspepsia DOID:2326 A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen. DOID:4094 DOID:5269 ICD10CM:K52.9 MESH:D005759 NCI:C34632 SNOMEDCT_US_2016_03_01:154278002 SNOMEDCT_US_2016_03_01:197010007 SNOMEDCT_US_2016_03_01:25374005 SNOMEDCT_US_2016_03_01:266179001 UMLS_CUI:C0017160 cholera morbus infectious colitis, enteritis and gastroenteritis disease_ontology DOID:2326 gastroenteritis DOID:2339 A craniosynostosis that involves premature fusion of certain skull bones. This early fusion prevents the skull from growing normally and affects the shape of the head and face. The disease is associated with mutations in the FGFR2 gene. ICD10CM:Q75.1 MESH:D003394 NCI:C84653 OMIM:123500 SNOMEDCT_US_2016_03_01:28861008 UMLS_CUI:C0010273 Craniofacial Dysostosis disease_ontology Crouzon's disease DOID:2339 OMIM mapping confirmed by DO. [SN]. Crouzon syndrome DOID:234 A colon carcinoma that derives_from epithelial cells of glandular origin. NCI:C4349 SNOMEDCT_US_2016_03_01:255082000 UMLS_CUI:C0338106 Colonic adenocarcinoma adenocarcinoma of colon disease_ontology adenocarcinoma of the colon DOID:234 colon adenocarcinoma DOID:2340 A synostosis that results_in premature fusion located_in skull. ICD10CM:Q75.0 MESH:D003398 NCI:C84655 OMIM:123100 OMIM:182212 OMIM:600593 OMIM:600775 OMIM:604757 OMIM:615314 OMIM:615529 ORDO:1531 SNOMEDCT_US_2016_03_01:205411004 SNOMEDCT_US_2016_03_01:205414007 SNOMEDCT_US_2016_03_01:57219006 UMLS_CUI:C0010278 Premature closure of cranial sutures disease_ontology DOID:2340 Xref MGI. OMIM mapping confirmed by DO. [SN]. OMIM mapping by NeuroDevNet. [LS]. craniosynostosis DOID:2345 An inherited metabolic disorder that involves plasma protein metabolism malfunction. ICD9CM:273.8 SNOMEDCT_US_2016_03_01:190822009 SNOMEDCT_US_2016_03_01:190825006 UMLS_CUI:C0029594 disease_ontology DOID:2345 plasma protein metabolism disease DOID:2348 ICD10CM:I25.1 ICD10CM:I70 ICD9CM:440 MESH:D050197 NCI:C34403 NCI:C35768 NCI:C35771 SNOMEDCT_US_2016_03_01:155382007 SNOMEDCT_US_2016_03_01:155414001 SNOMEDCT_US_2016_03_01:194848007 SNOMEDCT_US_2016_03_01:195121002 SNOMEDCT_US_2016_03_01:195251000 SNOMEDCT_US_2016_03_01:266318005 SNOMEDCT_US_2016_03_01:38716007 SNOMEDCT_US_2016_03_01:39468009 UMLS_CUI:C0004153 UMLS_CUI:C3665365 Arteriosclerotic Cardiovascular disease Arteriosclerotic cardiovascular disease Arteriosclerotic cardiovascular disease, NOS Atherosclerotic Cardiovascular disease Atherosclerotic cardiovascular disease Cardiovascular arteriosclerosis unspecified (disorder) disease_ontology DOID:2348 arteriosclerotic cardiovascular disease DOID:2349 An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries. CSP:0571-2299 ICD10CM:I70 MESH:D001161 NCI:C34398 SNOMEDCT_US_2016_03_01:107671003 SNOMEDCT_US_2016_03_01:155414001 SNOMEDCT_US_2016_03_01:155418003 SNOMEDCT_US_2016_03_01:195251000 SNOMEDCT_US_2016_03_01:195257001 SNOMEDCT_US_2016_03_01:266318005 SNOMEDCT_US_2016_03_01:28960008 SNOMEDCT_US_2016_03_01:72092001 UMLS_CUI:C0003850 Arteriosclerosis (morphologic abnormality) Arteriosclerosis NOS Arteriosclerotic vascular disease (disorder) Arteriosclerotic vascular disease NOS disease_ontology DOID:2349 arteriosclerosis DOID:235 An intestinal benign neoplasm that is located_in the colon. MESH:D003110 NCI:C2953 SNOMEDCT_US_2016_03_01:126838000 UMLS_CUI:C0009375 Colonic Mass Colonic tumor colon neoplasm neoplasm of colon (disorder) disease_ontology DOID:235 colonic benign neoplasm DOID:2351 ICD10CM:E83.1 ICD10CM:E83.10 ICD9CM:275.0 MESH:D019189 SNOMEDCT_US_2016_03_01:154751003 SNOMEDCT_US_2016_03_01:190851008 SNOMEDCT_US_2016_03_01:267504005 SNOMEDCT_US_2016_03_01:30913008 UMLS_CUI:C0012715 Iron disorder disorder of iron metabolism disorder of iron metabolism (disorder) disorder of iron metabolism NOS (disorder) iron disorder disease_ontology DOID:2351 iron metabolism disease DOID:2352 A metal metabolism disorder characterized by the accumulation of iron in various organs of the body. ICD10CM:E83.11 ICD10CM:E83.110 ICD10CM:E83.119 MESH:D006432 NCI:C84481 OMIM:231100 OMIM:235200 OMIM:602390 OMIM:604250 OMIM:606069 OMIM:613313 ORDO:139491 ORDO:139498 ORDO:225123 ORDO:79230 SNOMEDCT_US_2016_03_01:154751003 SNOMEDCT_US_2016_03_01:267504005 SNOMEDCT_US_2016_03_01:399144008 SNOMEDCT_US_2016_03_01:399187006 SNOMEDCT_US_2016_03_01:86781004 UMLS_CUI:C0018995 Haemochromatosis diabetes bronze iron storage disorder disease_ontology DOID:2352 Xref MGI. hemochromatosis DOID:2355 A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells. EFO:0004272 ICD10CM:D64.9 ICD9CM:285.9 MESH:D000740 NCI:C2869 SNOMEDCT_US_2016_03_01:154786001 SNOMEDCT_US_2016_03_01:154812000 SNOMEDCT_US_2016_03_01:191277004 SNOMEDCT_US_2016_03_01:267531008 SNOMEDCT_US_2016_03_01:271737000 SNOMEDCT_US_2016_03_01:64593003 UMLS_CUI:C0002871 anaemia disease_ontology DOID:2355 PRISM. anemia DOID:2367 MESH:D019150 SNOMEDCT_US_2016_03_01:230365004 UMLS_CUI:C0338473 disease_ontology DOID:2367 neuroaxonal dystrophy DOID:2368 ICD10CM:E75.10 MESH:D005733 SNOMEDCT_US_2016_03_01:50967008 UMLS_CUI:C0017083 mucolipidosis type IV disease_ontology DOID:2368 gangliosidosis DOID:2373 A hematopoietic system disease characterized by oval or elliptical red blood cells, slight or absent hemolysis with little or no anemia; splenomegaly is often present. ICD10CM:D58.1 ICD9CM:282.1 MESH:D004612 NCI:C35882 NCI:C36293 OMIM:130600 OMIM:611804 ORDO:288 SNOMEDCT_US_2016_03_01:154801000 SNOMEDCT_US_2016_03_01:178935009 SNOMEDCT_US_2016_03_01:191169008 SNOMEDCT_US_2016_03_01:267558001 SNOMEDCT_US_2016_03_01:58864003 UMLS_CUI:C0013902 Congenital elliptocytosis ovalocytosis disease_ontology DOID:2373 Xref MGI. OMIM mapping confirmed by DO. [SN]. hereditary elliptocytosis DOID:2377 A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. EFO:0003885 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:126200 OMIM:612594 OMIM:612595 OMIM:612596 OMIM:614810 SNOMEDCT_US_2016_03_01:155023009 SNOMEDCT_US_2016_03_01:192928003 SNOMEDCT_US_2016_03_01:192930001 SNOMEDCT_US_2016_03_01:24700007 UMLS_CUI:C0026769 Generalized multiple sclerosis (disorder) insular sclerosis disease_ontology DOID:2377 OMIM mapping confirmed by DO. [LS]. multiple sclerosis DOID:2382 A brain disease that is characterized by hyperbilirubinemia-induced brain dysfunction. ICD10CM:P57 ICD10CM:P57.9 MESH:D007647 NCI:C84799 SNOMEDCT_US_2016_03_01:157135006 SNOMEDCT_US_2016_03_01:206479002 SNOMEDCT_US_2016_03_01:230770008 SNOMEDCT_US_2016_03_01:268880009 SNOMEDCT_US_2016_03_01:50143004 SNOMEDCT_US_2016_03_01:74925009 UMLS_CUI:C0022610 bilirubin encephalopathy disease_ontology DOID:2382 kernicterus DOID:2383 A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant. ICD10CM:P59.9 MESH:D007567 NCI:C99246 SNOMEDCT_US_2016_03_01:111470007 SNOMEDCT_US_2016_03_01:206474007 SNOMEDCT_US_2016_03_01:276549000 SNOMEDCT_US_2016_03_01:299968002 SNOMEDCT_US_2016_03_01:30235009 SNOMEDCT_US_2016_03_01:31482007 SNOMEDCT_US_2016_03_01:387712008 UMLS_CUI:C0022353 neonatal hyperbilirubinemia neonatal icterus disease_ontology DOID:2383 neonatal jaundice DOID:2384 A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1). ICD10CM:E51.2 MESH:D014899 SNOMEDCT_US_2016_03_01:190626005 SNOMEDCT_US_2016_03_01:190627001 SNOMEDCT_US_2016_03_01:21007002 UMLS_CUI:C0043121 Wernicke's disease Wernicke's encephalopathy disease_ontology DOID:2384 Wernicke encephalopathy DOID:2394 A female reproductive organ cancer that is located_in the ovary. DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213517 SNOMEDCT_US_2016_03_01:123843001 SNOMEDCT_US_2016_03_01:154528000 SNOMEDCT_US_2016_03_01:363443007 SNOMEDCT_US_2016_03_01:372117006 SNOMEDCT_US_2016_03_01:93934004 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247 malignant Ovarian tumor malignant tumour of ovary ovarian neoplasm ovary neoplasm primary ovarian cancer tumor of the Ovary disease_ontology DOID:2394 Xref MGI. OMIM mapping confirmed by DO. [SN]. ovarian cancer DOID:2415 DOID:191 DOID:2418 DOID:5901 Magnocellular nevus Magnocellular nevus (morphologic abnormality) Naevus - benign benign melanocytic naevus benign melanocytic naevus of skin benign melanocytic nevus benign melanoma benign nevus of skin cutaneous melanocytic neoplasm melanocytic neoplasm melanocytic neoplasm (disorder) melanocytic neoplasm of skin melanocytic tumor of skin (disorder) melanocytoma disease_ontology DOID:2415 benign skin melanocytic nevus true DOID:2436 MESH:D005918 NCI:C4222 SNOMEDCT_US_2016_03_01:7429002 UMLS_CUI:C0334421 disease_ontology DOID:2436 glomangioma DOID:2444 MESH:D006964 SNOMEDCT_US_2016_03_01:10649000 SNOMEDCT_US_2016_03_01:154698000 SNOMEDCT_US_2016_03_01:267480001 UMLS_CUI:C0020506 disease_ontology DOID:2444 hyperpituitarism DOID:2449 A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb. MESH:D000172 NCI:C84533 SNOMEDCT_US_2016_03_01:154698000 SNOMEDCT_US_2016_03_01:267480001 SNOMEDCT_US_2016_03_01:74107003 UMLS_CUI:C0001206 disease_ontology DOID:2449 acromegaly DOID:2452 ICD10CM:D68.59 MESH:D019851 NCI:C84479 OMIM:188050 OMIM:614486 SNOMEDCT_US_2016_03_01:191302007 SNOMEDCT_US_2016_03_01:234467004 SNOMEDCT_US_2016_03_01:76612001 UMLS_CUI:C0398623 hypercoagulability state disease_ontology DOID:2452 OMIM mapping confirmed by DO. [LS]. thrombophilia DOID:2462 NCI:C35170 SNOMEDCT_US_2016_03_01:57534004 UMLS_CUI:C0154833 retina circulation disorder disease_ontology DOID:2462 retinal vascular disease DOID:2468 A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. EFO:0000677 ICD9CM:298.8 UMLS_CUI:C0029516 mental or behavioural disorder disease_ontology DOID:2468 psychotic disorder DOID:2473 A systemic mycosis that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices. DOID:0050137 ICD9CM:118 SNOMEDCT_US_2016_03_01:187108005 SNOMEDCT_US_2016_03_01:78999002 UMLS_CUI:C0029119 Opportunistic mycoses (disorder) Opportunistic mycosis (disorder) opportunistic systemic mycoses disease_ontology DOID:2473 opportunistic mycosis DOID:2475 ICD10CM:H10.4 ICD10CM:H10.40 ICD9CM:372.1 ICD9CM:372.10 NCI:C35197 SNOMEDCT_US_2016_03_01:155163007 SNOMEDCT_US_2016_03_01:193865006 SNOMEDCT_US_2016_03_01:193869000 SNOMEDCT_US_2016_03_01:73762008 UMLS_CUI:C0155145 Unspecified chronic conjunctivitis (disorder) chronic Conjunctivitis chronic conjunctivitis NOS (disorder) chronic conjunctivitis, unspecified disease_ontology DOID:2475 chronic conjunctivitis DOID:2477 ICD10CM:G60.0 MESH:D015417 NCI:C75467 SNOMEDCT_US_2016_03_01:128202008 SNOMEDCT_US_2016_03_01:155081008 SNOMEDCT_US_2016_03_01:193158000 SNOMEDCT_US_2016_03_01:193160003 SNOMEDCT_US_2016_03_01:193161004 SNOMEDCT_US_2016_03_01:398100001 UMLS_CUI:C0027888 HSMN HSMN - Hereditary sensory and motor neuropathy Hereditary motor and sensory neuropathy neuropathic muscular atrophy disease_ontology DOID:2477 motor peripheral neuropathy DOID:2485 ICD9CM:275.3 MESH:D010760 NCI:C97095 SNOMEDCT_US_2016_03_01:154752005 SNOMEDCT_US_2016_03_01:190858002 SNOMEDCT_US_2016_03_01:190862008 SNOMEDCT_US_2016_03_01:267505006 SNOMEDCT_US_2016_03_01:87049008 UMLS_CUI:C0031707 Phosphorus disorder disorder of phosphorus metabolism disorder of phosphorus metabolism (disorder) disorder of phosphorus metabolism NOS (disorder) phosphorus metabolism disorder disease_ontology DOID:2485 phosphorus metabolism disease DOID:2490 ICD9CM:742 SNOMEDCT_US_2016_03_01:204018008 UMLS_CUI:C0158538 congenital neurologic anomaly disease_ontology DOID:2490 congenital nervous system abnormality DOID:2494 A vascular disease that is characterized as a small vascular malformation of the gut. DOID:12071 ICD9CM:537.83 MESH:D016888 SNOMEDCT_US_2016_03_01:71072006 UMLS_CUI:C0085411 UMLS_CUI:C0156091 angiodysplasia of stomach and duodenum with hemorrhage disease_ontology DOID:2494 angiodysplasia DOID:2497 ICD9CM:521.31 UMLS_CUI:C1456161 disease_ontology DOID:2497 enamel erosion DOID:2498 DOID:11509 DOID:12687 ICD10CM:K03.2 ICD9CM:521.3 ICD9CM:521.34 ICD9CM:521.35 MESH:D014077 SNOMEDCT_US_2016_03_01:155634008 SNOMEDCT_US_2016_03_01:196315004 SNOMEDCT_US_2016_03_01:266486000 SNOMEDCT_US_2016_03_01:82212003 UMLS_CUI:C0040436 UMLS_CUI:C1456164 UMLS_CUI:C1456165 generalized erosion localized erosion disease_ontology DOID:2498 tooth erosion DOID:2508 A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body. DOID:13377 ICD10CM:M31.4 ICD9CM:446.7 MESH:D001015 MESH:D013625 NCI:C34391 NCI:C35062 OMIM:207600 SNOMEDCT_US_2016_03_01:155445002 SNOMEDCT_US_2016_03_01:195361009 SNOMEDCT_US_2016_03_01:266323005 SNOMEDCT_US_2016_03_01:359789008 SNOMEDCT_US_2016_03_01:42153001 UMLS_CUI:C0003490 UMLS_CUI:C0039263 (Aortic arch arteritis) or (Takayasu's disease[& pulseless]) Aortic Arch syndrome Aortic arch arteritis Aortic arch syndrome Idiopathic aortitis (disorder) Takayasu arteritis Takayasu's disease disease_ontology DOID:2508 OMIM mapping confirmed by DO. [SN]. Takayasu's arteritis DOID:2512 MESH:D001478 NCI:C2892 OMIM:109400 SNOMEDCT_US_2016_03_01:188145001 SNOMEDCT_US_2016_03_01:254704004 SNOMEDCT_US_2016_03_01:69408002 UMLS_CUI:C0004779 Gorlin syndrome basal cell nevus syndrome disease_ontology DOID:2512 OMIM mapping confirmed by DO. [SN]. nevoid basal cell carcinoma syndrome DOID:2513 A skin carcinoma affecting basal cells. DOID:4275 DOID:4276 CSP:2000-2719 EFO:0004193 HP:0002671 KEGG:05217 MESH:D002280 MESH:D018295 NCI:C2921 NCI:C3784 NCI:C7586 OMIM:605462 OMIM:613058 OMIM:613059 OMIM:613061 OMIM:613062 OMIM:613063 OMIM:614740 SNOMEDCT_US_2016_03_01:127570002 SNOMEDCT_US_2016_03_01:1338007 SNOMEDCT_US_2016_03_01:154507009 SNOMEDCT_US_2016_03_01:188083002 SNOMEDCT_US_2016_03_01:189572008 SNOMEDCT_US_2016_03_01:189573003 SNOMEDCT_US_2016_03_01:189574009 SNOMEDCT_US_2016_03_01:252995000 SNOMEDCT_US_2016_03_01:254701007 SNOMEDCT_US_2016_03_01:269582000 SNOMEDCT_US_2016_03_01:275265005 SNOMEDCT_US_2016_03_01:30649006 SNOMEDCT_US_2016_03_01:399049001 UMLS_CUI:C0007117 UMLS_CUI:C0206710 UMLS_CUI:C1368295 BASAL CELL carcinoma OF SKIN Basal cell cancer Basal cell carcinoma NOS (morphologic abnormality) Basal cell carcinoma of skin (disorder) Basal cell neoplasm (morphologic abnormality) Basal cell neoplasm NOS (morphologic abnormality) Basal cell tumor Basal cell tumor (morphologic abnormality) Epithelioma basal cell (disorder) Rodent ulcer malignant Basal cell neoplasm malignant basal cell tumor malignant basal cell tumor (morphologic abnormality) disease_ontology DOID:2513 Xref MGI. basal cell carcinoma DOID:2519 MESH:D013733 NCI:C26890 SNOMEDCT_US_2016_03_01:236763001 SNOMEDCT_US_2016_03_01:297228003 SNOMEDCT_US_2016_03_01:64910008 UMLS_CUI:C0039584 disorder of testis testis disorder disease_ontology DOID:2519 testicular disease DOID:2526 A prostate carcinoma that derives_from epithelial cells of glandular origin. NCI:C2919 SNOMEDCT_US_2016_03_01:399490008 UMLS_CUI:C0007112 disease_ontology DOID:2526 prostate adenocarcinoma DOID:2527 MESH:D009401 SNOMEDCT_US_2016_03_01:90708001 UMLS_CUI:C0027720 disease_ontology DOID:2527 nephrosis DOID:2529 DOID:0000815 ICD10CM:D73 ICD10CM:D73.9 ICD9CM:289.50 MESH:D013158 NCI:C35823 SNOMEDCT_US_2016_03_01:154839008 SNOMEDCT_US_2016_03_01:191381002 SNOMEDCT_US_2016_03_01:191385006 SNOMEDCT_US_2016_03_01:267570002 SNOMEDCT_US_2016_03_01:51244008 SNOMEDCT_US_2016_03_01:58381000 UMLS_CUI:C0037997 Dyssplenism Spleen disease disease_ontology DOID:2529 splenic disease DOID:2531 An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes. DOID:1034 DOID:2532 MESH:D019337 NCI:C27134 SNOMEDCT_US_2016_03_01:414388001 SNOMEDCT_US_2016_03_01:414644002 UMLS_CUI:C0376544 Hematologic malignancy Hematologic malignancy (disorder) Hematologic neoplasm (disorder) Hematological tumors blood cancer hematopoietic and lymphoid system tumor hematopoietic cancer hematopoietic neoplasm (morphologic abnormality) hematopoietic tumors malignant hematopoietic neoplasm (morphologic abnormality) disease_ontology DOID:2531 hematologic cancer DOID:2533 ICD10CM:D73.5 MESH:D013159 SNOMEDCT_US_2016_03_01:154839008 SNOMEDCT_US_2016_03_01:22996003 SNOMEDCT_US_2016_03_01:267570002 UMLS_CUI:C0037998 Splenic infarct Splenic infarction Splenic infarction (disorder) disease_ontology DOID:2533 splenic infarction DOID:2536 ICD10CM:G61.81 ICD9CM:357.81 MESH:D020277 NCI:C84636 SNOMEDCT_US_2016_03_01:128209004 SNOMEDCT_US_2016_03_01:444728005 UMLS_CUI:C0393819 disease_ontology DOID:2536 chronic inflammatory demyelinating polyneuritis DOID:2537 ICD9CM:357 ICD9CM:357.9 SNOMEDCT_US_2016_03_01:155060008 SNOMEDCT_US_2016_03_01:193172009 SNOMEDCT_US_2016_03_01:193204000 SNOMEDCT_US_2016_03_01:267601009 SNOMEDCT_US_2016_03_01:267603007 UMLS_CUI:C0154758 disease_ontology DOID:2537 inflammatory and toxic neuropathy DOID:2548 MESH:D020195 NCI:C85041 SNOMEDCT_US_2016_03_01:79745005 UMLS_CUI:C0270857 epilepsy, sensory-induced disease_ontology DOID:2548 reflex epilepsy DOID:255 A cell type benign neoplasm that has_physical_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood. ICD10CM:D18.0 ICD10CM:D18.00 ICD9CM:228.0 ICD9CM:228.00 MESH:D006391 NCI:C3085 SNOMEDCT_US_2016_03_01:154625006 SNOMEDCT_US_2016_03_01:189192007 SNOMEDCT_US_2016_03_01:189193002 SNOMEDCT_US_2016_03_01:189194008 SNOMEDCT_US_2016_03_01:189199003 SNOMEDCT_US_2016_03_01:189863005 SNOMEDCT_US_2016_03_01:2099007 SNOMEDCT_US_2016_03_01:253053003 SNOMEDCT_US_2016_03_01:254822005 SNOMEDCT_US_2016_03_01:269646001 SNOMEDCT_US_2016_03_01:367337005 SNOMEDCT_US_2016_03_01:400210000 SNOMEDCT_US_2016_03_01:93474003 UMLS_CUI:C0018916 disease_ontology DOID:255 hemangioma DOID:2559 A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance. ICD10CM:F11.2 ICD9CM:304.0 ICD9CM:304.00 MESH:D009293 SNOMEDCT_US_2016_03_01:191817000 SNOMEDCT_US_2016_03_01:191818005 SNOMEDCT_US_2016_03_01:192220003 SNOMEDCT_US_2016_03_01:75544000 UMLS_CUI:C0524662 Opioid type dependence disease_ontology DOID:2559 opiate dependence DOID:2560 An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance. MESH:D009021 SNOMEDCT_US_2016_03_01:191817000 SNOMEDCT_US_2016_03_01:231479000 SNOMEDCT_US_2016_03_01:286934009 UMLS_CUI:C0026552 disease_ontology DOID:2560 morphine dependence DOID:2566 DOID:8944 ICD10CM:H18.5 ICD10CM:H18.50 ICD9CM:371.5 ICD9CM:371.50 MESH:D003317 NCI:C34512 NCI:C34513 SNOMEDCT_US_2016_03_01:193831005 SNOMEDCT_US_2016_03_01:193832003 SNOMEDCT_US_2016_03_01:193842001 SNOMEDCT_US_2016_03_01:5587004 SNOMEDCT_US_2016_03_01:77797009 UMLS_CUI:C0010035 UMLS_CUI:C0010036 disease_ontology DOID:2566 corneal dystrophy DOID:2571 A histiocytosis that is characterized by clonal proliferation of Langerhans cells. DOID:10617 DOID:10618 DOID:10620 DOID:10623 DOID:10624 DOID:10625 DOID:2553 DOID:2554 DOID:9582 ICD10CM:C96.0 ICD10CM:C96.5 ICD10CM:C96.6 ICD9CM:202.5 MESH:C538636 MESH:D006646 NCI:C3107 NCI:C3160 NCI:C6920 OMIM:246400 OMIM:604856 SNOMEDCT_US_2016_03_01:110450007 SNOMEDCT_US_2016_03_01:118614007 SNOMEDCT_US_2016_03_01:128809007 SNOMEDCT_US_2016_03_01:128811003 SNOMEDCT_US_2016_03_01:128812005 SNOMEDCT_US_2016_03_01:154583006 SNOMEDCT_US_2016_03_01:154773005 SNOMEDCT_US_2016_03_01:188654004 SNOMEDCT_US_2016_03_01:188655003 SNOMEDCT_US_2016_03_01:188659009 SNOMEDCT_US_2016_03_01:190955000 SNOMEDCT_US_2016_03_01:190956004 SNOMEDCT_US_2016_03_01:190960001 SNOMEDCT_US_2016_03_01:234439008 SNOMEDCT_US_2016_03_01:236957004 SNOMEDCT_US_2016_03_01:267510005 SNOMEDCT_US_2016_03_01:269628007 SNOMEDCT_US_2016_03_01:366059005 SNOMEDCT_US_2016_03_01:39795003 SNOMEDCT_US_2016_03_01:65399007 SNOMEDCT_US_2016_03_01:67574008 UMLS_CUI:C0019621 UMLS_CUI:C0023381 Histiocytosis X Langerhan's cell histiocytosis (disorder) Langerhans cell granulomatosis Letterer-Siwe disease Letterer-Siwe disease involving intra-abdominal lymph nodes Letterer-Siwe disease involving intrapelvic lymph nodes Letterer-Siwe disease involving intrathoracic lymph nodes Letterer-Siwe disease involving lymph nodes of axilla and upper limb Letterer-Siwe disease involving lymph nodes of head, face and neck Letterer-Siwe disease involving lymph nodes of head, face, and neck Letterer-Siwe disease involving lymph nodes of inguinal region and lower limb Letterer-Siwe disease involving lymph nodes of multiple sites Letterer-Siwe disease involving spleen Letterer-Siwe disease of intra-abdominal lymph nodes Letterer-Siwe disease of intra-abdominal lymph nodes (disorder) Letterer-Siwe disease of intrapelvic lymph nodes Letterer-Siwe disease of intrapelvic lymph nodes (disorder) Letterer-Siwe disease of intrathoracic lymph nodes Letterer-Siwe disease of intrathoracic lymph nodes (disorder) Letterer-Siwe disease of lymph nodes of axilla and upper limb (disorder) Letterer-Siwe disease of lymph nodes of axilla and/or upper limb Letterer-Siwe disease of lymph nodes of axilla and/or upper limb (disorder) Letterer-Siwe disease of lymph nodes of head, face and neck (disorder) Letterer-Siwe disease of lymph nodes of head, face and/or neck (disorder) Letterer-Siwe disease of lymph nodes of inguinal region amd/or lower limb Letterer-Siwe disease of lymph nodes of inguinal region and lower limb (disorder) Letterer-Siwe disease of lymph nodes of inguinal region and/or lower limb (disorder) Letterer-Siwe disease of lymph nodes of multiple sites Letterer-Siwe disease of lymph nodes of multiple sites (disorder) Letterer-Siwe disease of spleen Letterer-Siwe disease of spleen (disorder) disease_ontology DOID:2571 OMIM mapping confirmed by DO. [SN]. Langerhans-cell histiocytosis DOID:2575 A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance. ICD9CM:304.11 SNOMEDCT:231472009 UMLS_CUI:C0154482 disease_ontology DOID:2575 barbiturate dependence DOID:2581 ICD10CM:Q77.3 MESH:D002806 NCI:C84632 OMIM:215105 SNOMEDCT_US_2016_03_01:205486004 SNOMEDCT_US_2016_03_01:22932004 SNOMEDCT_US_2016_03_01:278715001 SNOMEDCT_US_2016_03_01:360507004 SNOMEDCT_US_2016_03_01:42778005 UMLS_CUI:C0008445 Chondrodysplasia calcificans congenita Chondrodysplasia punctata congenita (disorder) disease_ontology DOID:2581 DeObs MGI. chondrodysplasia punctata DOID:2583 A B cell deficiency that is caused by a reduction in all types of gamma globulins. DOID:618 ICD10CM:D80.1 ICD9CM:279.00 MESH:D000361 NCI:C26931 OMIM:601495 OMIM:612692 OMIM:613500 OMIM:613501 OMIM:613502 OMIM:613506 OMIM:615214 SNOMEDCT_US_2016_03_01:119249001 SNOMEDCT_US_2016_03_01:119250001 SNOMEDCT_US_2016_03_01:190977001 SNOMEDCT_US_2016_03_01:190978006 SNOMEDCT_US_2016_03_01:267512002 SNOMEDCT_US_2016_03_01:81282009 UMLS_CUI:C0001768 UMLS_CUI:C0086438 IGHM hypogammaglobulinemia mu heavy chain deficiency disease_ontology DOID:2583 OMIM mapping confirmed by DO. [SN]. agammaglobulinemia DOID:2590 ICD10CM:N04 MESH:C535761 NCI:C35337 SNOMEDCT_US_2016_03_01:197602005 SNOMEDCT_US_2016_03_01:48796009 UMLS_CUI:C3501848 Congenital Nephrotic syndrome Congenital nephrotic syndrome disease_ontology DOID:2590 familial nephrotic syndrome DOID:2596 A respiratory system cancer that is located_in the larynx. ICD10CM:C32 ICD10CM:C32.9 ICD9CM:161 ICD9CM:161.9 MESH:D007822 NCI:C7484 SNOMEDCT_US_2016_03_01:154484002 SNOMEDCT_US_2016_03_01:187851007 SNOMEDCT_US_2016_03_01:269560007 SNOMEDCT_US_2016_03_01:363429002 SNOMEDCT_US_2016_03_01:93859007 UMLS_CUI:C0007107 disease_ontology DOID:2596 larynx cancer DOID:26 An endocrine system disease that is located_in the pancreas. ICD10CM:K86.8 ICD9CM:577.8 SNOMEDCT_US_2016_03_01:197566002 UMLS_CUI:C0029771 disease_ontology DOID:26 pancreas disease DOID:2602 A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern. MESH:D002812 NCI:C53459 SNOMEDCT_US_2016_03_01:154611005 SNOMEDCT_US_2016_03_01:187899007 SNOMEDCT_US_2016_03_01:188980001 SNOMEDCT_US_2016_03_01:189885004 SNOMEDCT_US_2016_03_01:269638002 SNOMEDCT_US_2016_03_01:31186001 UMLS_CUI:C0936248 Chondroma (morphologic abnormality) Chondroma NOS (morphologic abnormality) central Chondroma disease_ontology DOID:2602 chondroma DOID:2615 A cell type benign neoplam that is composed_of epithelial tissue on papillae of vascularized connective tissue. DOID:1635 MESH:D010212 NCI:C3713 NCI:C7440 SNOMEDCT_US_2016_03_01:189564006 SNOMEDCT_US_2016_03_01:23730008 SNOMEDCT_US_2016_03_01:711329002 SNOMEDCT_US_2016_03_01:82049002 UMLS_CUI:C0030354 UMLS_CUI:C0205875 papilloma (except papilloma of bladder M-81201) (morphologic abnormality) papillomatosis papillomatosis NOS (morphologic abnormality) papillomatosis, NOS disease_ontology DOID:2615 papilloma DOID:2621 A peripheral nervous system neoplasm that is located_in the autonomic nervous system. NCI:C5112 UMLS_CUI:C1332356 tumor of Autonomic nervous system disease_ontology DOID:2621 autonomic nervous system neoplasm DOID:263 A urinary system cancer that is located_in the kidney. DOID:11834 DOID:3676 ICD10CM:C64 ICD9CM:189.0 MESH:D007680 NCI:C120456 NCI:C3150 NCI:C7548 SNOMEDCT_US_2016_03_01:126880001 SNOMEDCT_US_2016_03_01:154542008 SNOMEDCT_US_2016_03_01:188249002 SNOMEDCT_US_2016_03_01:363518003 SNOMEDCT_US_2016_03_01:93849006 UMLS_CUI:C0022665 UMLS_CUI:C0494158 UMLS_CUI:C0740457 malignant neoplasm of kidney except pelvis malignant tumour of kidney renal cancer disease_ontology DOID:263 kidney cancer DOID:2645 A cell type benign neoplasm that has_material_basis in mesothelium. DOID:2644 ICD10CM:C45 ICD10CM:C45.9 MESH:D008654 NCI:C3234 SNOMEDCT_US_2016_03_01:154491004 SNOMEDCT_US_2016_03_01:187873000 SNOMEDCT_US_2016_03_01:189837000 SNOMEDCT_US_2016_03_01:190110008 SNOMEDCT_US_2016_03_01:62064005 UMLS_CUI:C0025500 benign tumor of Mesothelium disease_ontology DOID:2645 benign mesothelioma DOID:2649 MESH:D002804 NCI:C2945 SNOMEDCT_US_2016_03_01:134337007 SNOMEDCT_US_2016_03_01:189887007 SNOMEDCT_US_2016_03_01:9001003 UMLS_CUI:C0008441 Chondroblastoma of bone disease_ontology DOID:2649 chondroblastoma DOID:2661 A sweat gland neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland. MESH:D009208 NCI:C40392 SNOMEDCT_US_2016_03_01:69291002 UMLS_CUI:C0027070 Myoepithelial adenoma Myoepithelial neoplasm benign myoepithelioma disease_ontology DOID:2661 myoepithelioma DOID:2664 MESH:D013544 NCI:C3398 SNOMEDCT_US_2016_03_01:126490003 SNOMEDCT_US_2016_03_01:12933008 SNOMEDCT_US_2016_03_01:189665000 UMLS_CUI:C0038987 Sweat gland tumor (morphologic abnormality) Sweat gland tumor NOS (morphologic abnormality) neoplasm of sweat gland (disorder) tumor of the Sweat gland disease_ontology DOID:2664 sweat gland neoplasm DOID:2671 A carcinoma that derives_from transitional epithelial cells. DOID:3995 MESH:D002295 NCI:C2930 NCI:C6783 SNOMEDCT_US_2016_03_01:118287003 SNOMEDCT_US_2016_03_01:189576006 SNOMEDCT_US_2016_03_01:27090000 UMLS_CUI:C0007138 UMLS_CUI:C0334265 transitional carcinoma transitional cell tumor urothelial cell carcinoma disease_ontology transitional cell neoplasm DOID:2671 transitional cell carcinoma DOID:2679 NCI:C9505 SNOMEDCT_US_2016_03_01:128788005 SNOMEDCT_US_2016_03_01:87211000119104 UMLS_CUI:C1266177 Dysembryoplastic Neuroepithelial neoplasm Dysembryoplastic neuroepithelial tumor (morphologic abnormality) disease_ontology DOID:2679 dysembryoplastic neuroepithelial tumor DOID:2691 ICD10CM:D21 MESH:D009214 NCI:C4882 SNOMEDCT_US_2016_03_01:66357004 SNOMEDCT_US_2016_03_01:92237006 UMLS_CUI:C0027086 benign neoplasm of the Muscle disease_ontology DOID:2691 myoma DOID:2696 MESH:D007984 NCI:C3188 SNOMEDCT_US_2016_03_01:189739005 SNOMEDCT_US_2016_03_01:45002009 UMLS_CUI:C0023601 Leydig cell neoplasm disease_ontology DOID:2696 Leydig cell tumor DOID:2702 ICD10CM:M12.2 MESH:D013586 NCI:C3401 SNOMEDCT_US_2016_03_01:202903009 SNOMEDCT_US_2016_03_01:703703002 SNOMEDCT_US_2016_03_01:71508003 SNOMEDCT_US_2016_03_01:95412009 UMLS_CUI:C0039106 Diffuse Giant cell tumor of Tenosynovium villous tenosynovitis disease_ontology DOID:2702 pigmented villonodular synovitis DOID:2703 A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling. MESH:D013585 NCI:C50766 SNOMEDCT_US_2016_03_01:14107000 SNOMEDCT_US_2016_03_01:156666009 SNOMEDCT_US_2016_03_01:268092005 SNOMEDCT_US_2016_03_01:416209007 UMLS_CUI:C0039103 disease_ontology DOID:2703 synovitis DOID:2706 NCI:C6531 UMLS_CUI:C1334624 malignant tumor of Synovium disease_ontology DOID:2706 synovium cancer DOID:2710 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building. MESH:D018877 SNOMEDCT_US_2016_03_01:19076009 UMLS_CUI:C0037050 disease_ontology DOID:2710 sick building syndrome DOID:2717 An autosomal recessive disease characterized by sun sensitivity, short stature, predisposition to the development of cancer and genomic instability. MESH:D001816 NCI:C2903 OMIM:210900 ORDO:125 SNOMEDCT_US_2016_03_01:4434006 UMLS_CUI:C0005859 Bloom-Torre-Machacek syndrome Congenital Telangiectatic Erythema syndrome disease_ontology DOID:2717 OMIM mapping confirmed by DO. [SN]. Bloom syndrome DOID:2718 ICD10CM:J94.2 MESH:D006468 SNOMEDCT_US_2016_03_01:16632002 UMLS_CUI:C0019077 disease_ontology DOID:2718 hemopneumothorax DOID:272 A vascular disease that is located_in the liver. NCI:C35442 SNOMEDCT_US_2016_03_01:235878005 UMLS_CUI:C0400923 vascular disorder of liver (disorder) disease_ontology DOID:272 hepatic vascular disease DOID:2722 A dermatitis that selectively affects the hands and feet. CSP:4008-0032 MESH:D000169 NCI:C84532 SNOMEDCT_US_2016_03_01:8197001 UMLS_CUI:C0001197 disease_ontology DOID:2722 acrodermatitis DOID:2723 A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin. DOID:8614 DOID:8917 ICD10CM:L30.9 MESH:D003872 NCI:C2983 SNOMEDCT_US_2016_03_01:156358005 SNOMEDCT_US_2016_03_01:156388001 SNOMEDCT_US_2016_03_01:182782007 SNOMEDCT_US_2016_03_01:200884006 SNOMEDCT_US_2016_03_01:238538009 SNOMEDCT_US_2016_03_01:267847004 SNOMEDCT_US_2016_03_01:267856007 SNOMEDCT_US_2016_03_01:43116000 SNOMEDCT_US_2016_03_01:4979002 SNOMEDCT_US_2016_03_01:703938007 UMLS_CUI:C0011603 eczema skin inflammation disease_ontology DOID:2723 dermatitis DOID:2725 ICD10CM:Q82.5 MESH:D018324 NCI:C6645 SNOMEDCT_US_2016_03_01:205560007 SNOMEDCT_US_2016_03_01:254206003 SNOMEDCT_US_2016_03_01:402867006 SNOMEDCT_US_2016_03_01:56975005 SNOMEDCT_US_2016_03_01:83343001 UMLS_CUI:C0206733 Capillary hemangioma (disorder) Capillary hemangioma (morphologic abnormality) Congenital vascular hamartoma Congenital vascular naevus Infantile hemangioma Juvenile hemangioma Strawberry haemangioma Strawberry nevus Strawberry nevus of skin (disorder) cellular hemangioma of Infancy (Strawberry nevus) disease_ontology DOID:2725 capillary hemangioma DOID:2741 An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism. DOID:2740 MESH:D006932 MESH:D006933 NCI:C84761 SNOMEDCT_US_2016_03_01:143932000 SNOMEDCT_US_2016_03_01:14783006 SNOMEDCT_US_2016_03_01:154770008 SNOMEDCT_US_2016_03_01:166612004 SNOMEDCT_US_2016_03_01:20505009 SNOMEDCT_US_2016_03_01:235904007 SNOMEDCT_US_2016_03_01:267509000 UMLS_CUI:C0020433 UMLS_CUI:C0020435 hereditary hyperbilirubinemia hyperbilirubinemia disease_ontology hyperbilirubinaemia DOID:2741 bilirubin metabolic disorder DOID:2742 DOID:1490 DOID:2011 ICD10CM:H93.9 ICD10CM:H93.90 ICD9CM:388.9 MESH:D004427 NCI:C26757 SNOMEDCT_US_2016_03_01:155253008 SNOMEDCT_US_2016_03_01:155261003 SNOMEDCT_US_2016_03_01:194193002 SNOMEDCT_US_2016_03_01:194410006 SNOMEDCT_US_2016_03_01:25906001 SNOMEDCT_US_2016_03_01:267768008 UMLS_CUI:C0013447 ear and mastoid disease disease_ontology DOID:2742 auditory system disease DOID:2744 ICD10CM:N12 MESH:D011702 NCI:C34964 SNOMEDCT_US_2016_03_01:197780007 SNOMEDCT_US_2016_03_01:27174002 UMLS_CUI:C0034183 disease_ontology DOID:2744 pyelitis DOID:2747 A glycogen metabolism disorder that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types. ICD10CM:E74.0 ICD10CM:E74.00 ICD9CM:271.0 MESH:D006008 NCI:C61272 SNOMEDCT_US_2016_03_01:154738008 SNOMEDCT_US_2016_03_01:190744005 SNOMEDCT_US_2016_03_01:267498002 SNOMEDCT_US_2016_03_01:29633007 UMLS_CUI:C0017919 glycogenosis glycogenoses disease_ontology DOID:2747 glycogen storage disease DOID:2768 A tic disorder that consists of multiple motor and/or phonic tics with duration of at least 4 weeks, but less than 12 months. ICD10CM:F95.0 ICD9CM:307.21 MESH:D013981 NCI:C116767 SNOMEDCT_US_2016_03_01:192622000 SNOMEDCT_US_2016_03_01:56573006 UMLS_CUI:C0040702 disease_ontology DOID:2768 transient tic disorder DOID:2769 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity. ICD10CM:F95 ICD10CM:F95.9 ICD9CM:307.2 ICD9CM:307.20 MESH:D013981 SNOMEDCT_US_2016_03_01:112086008 SNOMEDCT_US_2016_03_01:155005001 SNOMEDCT_US_2016_03_01:191988002 SNOMEDCT_US_2016_03_01:191989005 SNOMEDCT_US_2016_03_01:191991002 SNOMEDCT_US_2016_03_01:192621007 SNOMEDCT_US_2016_03_01:192626002 SNOMEDCT_US_2016_03_01:35042001 SNOMEDCT_US_2016_03_01:386783003 SNOMEDCT_US_2016_03_01:393585001 SNOMEDCT_US_2016_03_01:568005 UMLS_CUI:C0040188 disease_ontology DOID:2769 tic disorder DOID:2772 ICD10CM:L24 ICD10CM:L24.9 MESH:D017453 NCI:C27151 SNOMEDCT_US_2016_03_01:110979008 SNOMEDCT_US_2016_03_01:200850007 UMLS_CUI:C0162823 Irritant Contact Dermatitis Irritant contact dermatitis primary irritant dermatitis (disorder) disease_ontology DOID:2772 irritant dermatitis DOID:2773 ICD10CM:L25 ICD10CM:L25.9 MESH:D003877 NCI:C26743 SNOMEDCT_US_2016_03_01:156338009 SNOMEDCT_US_2016_03_01:156348006 SNOMEDCT_US_2016_03_01:200780008 SNOMEDCT_US_2016_03_01:200883000 SNOMEDCT_US_2016_03_01:200889001 SNOMEDCT_US_2016_03_01:267842005 SNOMEDCT_US_2016_03_01:267846008 SNOMEDCT_US_2016_03_01:40275004 UMLS_CUI:C0011616 Contact dermatitis (disorder) Contact dermatitis NOS Contact dermatitis NOS (disorder) Contact dermatitis/eczema Contact eczema Dermatitis, venenata NOS dermatitis venenata disease_ontology DOID:2773 contact dermatitis DOID:2786 MESH:D002526 SNOMEDCT_US_2016_03_01:155010002 SNOMEDCT_US_2016_03_01:192867005 SNOMEDCT_US_2016_03_01:223176004 SNOMEDCT_US_2016_03_01:224186005 SNOMEDCT_US_2016_03_01:267691001 SNOMEDCT_US_2016_03_01:307361005 SNOMEDCT_US_2016_03_01:49784007 UMLS_CUI:C0007760 disease_ontology DOID:2786 cerebellar disease DOID:2789 A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes. DOID:0060003 DOID:10553 DOID:3734 DOID:3804 DOID:947 ICD10CM:B50-B64 ICD10CM:B64 MESH:D011528 NCI:C34953 SNOMEDCT_US_2016_03_01:187247003 SNOMEDCT_US_2016_03_01:187502000 SNOMEDCT_US_2016_03_01:187517001 SNOMEDCT_US_2016_03_01:240627001 SNOMEDCT_US_2016_03_01:367372008 SNOMEDCT_US_2016_03_01:89933001 SNOMEDCT_US_2016_03_01:95896000 UMLS_CUI:C0033740 mastigophora infectious disease sarcomastigophora infectious disease disease_ontology DOID:2789 parasitic protozoa infectious disease DOID:2797 A pneumonia located_in the lung parenchyma of unknown cause. ICD10CM:J84.11 ICD10CM:J84.112 ICD10CM:J84.114 MESH:D011658 SNOMEDCT_US_2016_03_01:129459004 SNOMEDCT_US_2016_03_01:155624004 SNOMEDCT_US_2016_03_01:196123009 SNOMEDCT_US_2016_03_01:196125002 SNOMEDCT_US_2016_03_01:196126001 SNOMEDCT_US_2016_03_01:233721005 SNOMEDCT_US_2016_03_01:236302005 SNOMEDCT_US_2016_03_01:266410004 SNOMEDCT_US_2016_03_01:45157009 SNOMEDCT_US_2016_03_01:700250006 UMLS_CUI:C0085786 Diffuse idiopathic pulmonary fibrosis Idiopathic fibrosing alveolitis disease_ontology IPF DOID:2797 idiopathic interstitial pneumonia DOID:28 A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. ICD10CM:E34.9 ICD9CM:259.9 MESH:D004700 NCI:C3009 SNOMEDCT_US_2016_03_01:118639003 SNOMEDCT_US_2016_03_01:127345001 SNOMEDCT_US_2016_03_01:154648001 SNOMEDCT_US_2016_03_01:154690007 SNOMEDCT_US_2016_03_01:154718007 SNOMEDCT_US_2016_03_01:190231001 SNOMEDCT_US_2016_03_01:190594008 SNOMEDCT_US_2016_03_01:267462005 SNOMEDCT_US_2016_03_01:267475005 SNOMEDCT_US_2016_03_01:267489000 SNOMEDCT_US_2016_03_01:362969004 SNOMEDCT_US_2016_03_01:67432001 UMLS_CUI:C0014130 disease_ontology DOID:28 endocrine system disease DOID:2815 ICD10CM:C72.50 ICD9CM:192.0 MESH:D003390 NCI:C3571 SNOMEDCT_US_2016_03_01:188307009 SNOMEDCT_US_2016_03_01:188311003 SNOMEDCT_US_2016_03_01:93767009 UMLS_CUI:C0153644 malignant neoplasm of cranial nerve malignant neoplasm of cranial nerves malignant neoplasm of cranial nerves NOS (disorder) malignant tumor of cranial nerve (disorder) malignant tumor of the Cranial nerve disease_ontology DOID:2815 cranial nerve malignant neoplasm DOID:2825 MESH:D009668 SNOMEDCT_US_2016_03_01:89488007 UMLS_CUI:C0028432 disorder of the nose (disorder) nasal disorder disease_ontology DOID:2825 nose disease DOID:2834 ICD10CM:D75.1 ICD9CM:289.0 NCI:C27178 SNOMEDCT_US_2016_03_01:154835002 SNOMEDCT_US_2016_03_01:191374009 SNOMEDCT_US_2016_03_01:44865000 UMLS_CUI:C1318533 Polycythemia, secondary secondary Polycythemia secondary polycythemia secondary polycythemia (disorder) secondary polycythemia NOS (disorder) disease_ontology DOID:2834 acquired polycythemia DOID:2841 A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 EFO:0000270 ICD10CM:J45 ICD10CM:J45.90 ICD10CM:J45.909 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 SNOMEDCT_US_2016_03_01:155574008 SNOMEDCT_US_2016_03_01:155579003 SNOMEDCT_US_2016_03_01:187687003 SNOMEDCT_US_2016_03_01:195967001 SNOMEDCT_US_2016_03_01:195979001 SNOMEDCT_US_2016_03_01:195983001 SNOMEDCT_US_2016_03_01:21341004 SNOMEDCT_US_2016_03_01:266365004 SNOMEDCT_US_2016_03_01:266398009 SNOMEDCT_US_2016_03_01:278517007 UMLS_CUI:C0004096 Exercise induced asthma bronchial hyperreactivity chronic obstructive asthma chronic obstructive asthma with acute exacerbation chronic obstructive asthma with status asthmaticus exercise-induced asthma disease_ontology DOID:2841 Xref MGI. asthma DOID:2842 MESH:D029593 NCI:C84793 OMIM:220400 OMIM:612347 SNOMEDCT_US_2016_03_01:373905003 SNOMEDCT_US_2016_03_01:49518001 UMLS_CUI:C0022387 Jervell and Lange-Nielson syndrome (disorder) disease_ontology DOID:2842 OMIM mapping confirmed by DO. [SN]. Jervell-Lange Nielsen syndrome DOID:2843 An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles). DOID:4069 ICD10CM:I45.81 ICD9CM:426.82 MESH:D008133 MESH:D029597 NCI:C34786 NCI:C85049 SNOMEDCT_US_2016_03_01:20852007 SNOMEDCT_US_2016_03_01:395649008 SNOMEDCT_US_2016_03_01:9651007 UMLS_CUI:C0023976 UMLS_CUI:C0035828 LQT Romano-Ward syndrome Romano-Ward syndrome (disorder) long Q-T syndrome disease_ontology DOID:2843 OMIM mapping confirmed by DO. [SN]. long QT syndrome DOID:2846 A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping. DOID:8891 ICD10CM:F45.8 ICD10CM:G47.63 ICD9CM:327.53 MESH:D002012 MESH:D020186 NCI:C73511 SNOMEDCT_US_2016_03_01:154925009 SNOMEDCT_US_2016_03_01:191983006 SNOMEDCT_US_2016_03_01:192436003 SNOMEDCT_US_2016_03_01:268774006 SNOMEDCT_US_2016_03_01:274950005 SNOMEDCT_US_2016_03_01:367105000 SNOMEDCT_US_2016_03_01:90207007 UMLS_CUI:C0006325 UMLS_CUI:C0393774 Bruxism - teeth grinding Grinding teeth Teeth grinding sleep related bruxism disease_ontology DOID:2846 bruxism DOID:2848 MESH:D003866 NCI:C34812 SNOMEDCT_US_2016_03_01:35489007 UMLS_CUI:C0025193 disease_ontology DOID:2848 melancholia DOID:285 A chronic lymphocytic leukemia that is characterized by over production of B cells (lymphocytes) by the bone marrow where the B cells appear hairy under a microscope. ICD10CM:C91.4 ICD10CM:C91.40 ICD9CM:202.4 MESH:D007943 NCI:C7402 SNOMEDCT_US_2016_03_01:118613001 SNOMEDCT_US_2016_03_01:188644003 SNOMEDCT_US_2016_03_01:188653005 SNOMEDCT_US_2016_03_01:190066005 SNOMEDCT_US_2016_03_01:54087003 SNOMEDCT_US_2016_03_01:85228003 UMLS_CUI:C0023443 disease_ontology DOID:285 hairy cell leukemia DOID:2855 MESH:D006981 UMLS_CUI:C0020551 disease_ontology DOID:2855 hyperthyroxinemia DOID:2861 MESH:D000746 OMIM:206300 OMIM:206400 OMIM:300908 OMIM:613470 ORDO:712 SNOMEDCT_US_2016_03_01:300389006 SNOMEDCT_US_2016_03_01:301317008 SNOMEDCT_US_2016_03_01:82775009 UMLS_CUI:C0002882 HNSHA hereditary nonspherocytic hemolytic anemia disease_ontology DOID:2861 Xref MGI. OMIM mapping by NeuroDevNet. [LS]. congenital nonspherocytic hemolytic anemia DOID:2862 A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH). MESH:D005955 NCI:C98933 SNOMEDCT_US_2016_03_01:124134002 SNOMEDCT_US_2016_03_01:154738008 SNOMEDCT_US_2016_03_01:267498002 SNOMEDCT_US_2016_03_01:62403005 UMLS_CUI:C2939465 Glucose-6-phosphate dehydrogenase deficiency deficiency of G-6PD disease_ontology DOID:2862 glucosephosphate dehydrogenase deficiency DOID:2870 An endometrial carcinoma that derives_from epithelial cells of glandular origin. DOID:5827 DOID:6650 NCI:C6287 NCI:C6290 NCI:C7359 SNOMEDCT_US_2016_03_01:123845008 SNOMEDCT_US_2016_03_01:189649001 SNOMEDCT_US_2016_03_01:189652009 SNOMEDCT_US_2016_03_01:309245001 UMLS_CUI:C0279763 UMLS_CUI:C1153706 UMLS_CUI:C1336905 adenocarcinoma of endometrium (disorder) adenocarcinoma of the Endometrium adenocarcinoma of uterus (disorder) endometrial adenoacanthoma endometrial endometrioid adenocarcinoma endometrial endometrioid adenocarcinoma with squamous differentiation endometrioid adenoma or carcinoma NOS (morphologic abnormality) endometrioid adenomas and carcinomas (morphologic abnormality) endometrioid carcinoma of Endometrium disease_ontology DOID:2870 endometrial adenocarcinoma DOID:2871 A endometrial cancer that is located_in the tissue lining the uterus. DOID:3000 MESH:D016889 MESH:D018269 NCI:C3769 NCI:C7558 SNOMEDCT_US_2016_03_01:154526001 SNOMEDCT_US_2016_03_01:254878006 SNOMEDCT_US_2016_03_01:269600001 SNOMEDCT_US_2016_03_01:30289006 SNOMEDCT_US_2016_03_01:93781006 UMLS_CUI:C0206687 UMLS_CUI:C0476089 carcinoma of the Endometrium endometrioid carcinoma endometrioid carcinoma of female Reproductive system disease_ontology DOID:2871 OMIM mapping confirmed by DO. [SN]. endometrial carcinoma DOID:2889 MESH:D012181 UMLS_CUI:C0035352 disease_ontology DOID:2889 retrocochlear disease DOID:289 A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body. EFO:0001065 ICD10CM:N80 ICD10CM:N80.9 ICD9CM:617 ICD9CM:617.9 MESH:D004715 NCI:C3014 SNOMEDCT_US_2016_03_01:103677003 SNOMEDCT_US_2016_03_01:11871002 SNOMEDCT_US_2016_03_01:129103003 SNOMEDCT_US_2016_03_01:155988000 SNOMEDCT_US_2016_03_01:198246007 SNOMEDCT_US_2016_03_01:198259004 SNOMEDCT_US_2016_03_01:266588002 SNOMEDCT_US_2016_03_01:396224008 UMLS_CUI:C0014175 disease_ontology DOID:289 endometriosis DOID:2891 MESH:D013964 NCI:C3502 SNOMEDCT_US_2016_03_01:154623004 SNOMEDCT_US_2016_03_01:189174004 SNOMEDCT_US_2016_03_01:255033000 SNOMEDCT_US_2016_03_01:255034006 SNOMEDCT_US_2016_03_01:269644003 UMLS_CUI:C0151468 adenoma of thyroid gland disease_ontology DOID:2891 thyroid adenoma DOID:2893 A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C9039 SNOMEDCT_US_2016_03_01:154522004 SNOMEDCT_US_2016_03_01:154525002 SNOMEDCT_US_2016_03_01:188174005 SNOMEDCT_US_2016_03_01:269596006 SNOMEDCT_US_2016_03_01:269599004 SNOMEDCT_US_2016_03_01:285432005 SNOMEDCT_US_2016_03_01:93752005 UMLS_CUI:C0302592 cancer of cervix carcinoma OF CERVIX carcinoma cervix uteri carcinoma of cervix (disorder) carcinoma of the Cervix Uteri disease_ontology DOID:2893 OMIM mapping confirmed by DO. [SN]. cervix carcinoma DOID:2908 ICD10CM:Q75.4 MESH:D008342 NCI:C75018 OMIM:154500 OMIM:248390 OMIM:613717 SNOMEDCT_US_2016_03_01:205416009 SNOMEDCT_US_2016_03_01:205804007 SNOMEDCT_US_2016_03_01:82203000 UMLS_CUI:C0242387 (Mandibulofacial dysostosis) or (Franceschetti syndrome) mandibulofacial dysostosis disease_ontology DOID:2908 OMIM mapping confirmed by DO. [SN]. Treacher Collins syndrome DOID:2914 A disease of anatomical entity that is located_in the immune system. EFO:0000540 ICD10CM:D89.9 ICD9CM:279 ICD9CM:279.9 SNOMEDCT_US_2016_03_01:154782004 SNOMEDCT_US_2016_03_01:191015009 SNOMEDCT_US_2016_03_01:191019003 SNOMEDCT_US_2016_03_01:191035005 UMLS_CUI:C0041806 disease_ontology DOID:2914 immune system disease DOID:2916 ICD10CM:C88.9 MESH:D007160 SNOMEDCT_US_2016_03_01:127071007 SNOMEDCT_US_2016_03_01:134363002 SNOMEDCT_US_2016_03_01:86295000 UMLS_CUI:C0021070 disease_ontology immunoproliferative disease DOID:2916 hypersensitivity reaction type IV disease DOID:2921 A nephritis that causes inflammation of the glomeruli located_in kidney. ICD10CM:N05 ICD10CM:N08 MESH:D005921 NCI:C26784 SNOMEDCT_US_2016_03_01:197648001 SNOMEDCT_US_2016_03_01:36171008 UMLS_CUI:C0017658 disease_ontology DOID:2921 glomerulonephritis DOID:2926 A syndrome that is characterized by large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. ICD10CM:Q87.2 MESH:D007715 NCI:C84801 OMIM:149000 SNOMEDCT_US_2016_03_01:59078009 UMLS_CUI:C0022739 Haemangiectatic hypertrophy Klippel-Trenaunay-Weber syndrome angioosteohypertrophy syndrome disease_ontology DOID:2926 OMIM mapping confirmed by DO. [SN]. Klippel-Trenaunay syndrome DOID:2945 A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia. ICD10CM:J12.81 ICD9CM:079.82 MESH:D045169 NCI:C85064 SNOMEDCT_US_2016_03_01:398447004 UMLS_CUI:C1175175 SARS SARS-CoV infection disease_ontology DOID:2945 severe acute respiratory syndrome DOID:2951 ICD10CM:T75.3 ICD9CM:994.6 MESH:D009041 NCI:C34824 OMIM:158280 SNOMEDCT_US_2016_03_01:157749008 SNOMEDCT_US_2016_03_01:212973000 SNOMEDCT_US_2016_03_01:212974006 SNOMEDCT_US_2016_03_01:269278001 SNOMEDCT_US_2016_03_01:37031009 UMLS_CUI:C0026603 Travel Sickness disease_ontology DOID:2951 OMIM mapping confirmed by DO. [SN]. motion sickness DOID:2952 ICD10CM:H80-H83 ICD10CM:H83.9 ICD10CM:H83.90 MESH:D007759 NCI:C27166 SNOMEDCT_US_2016_03_01:194690003 SNOMEDCT_US_2016_03_01:20425006 SNOMEDCT_US_2016_03_01:232297009 SNOMEDCT_US_2016_03_01:267761002 SNOMEDCT_US_2016_03_01:267763004 SNOMEDCT_US_2016_03_01:286945007 UMLS_CUI:C0022890 UMLS_CUI:C0494559 labyrinthine disease disease_ontology DOID:2952 inner ear disease DOID:2959 NCI:C27579 UMLS_CUI:C1334069 disease_ontology DOID:2959 hyperimmunoglobulin syndrome DOID:2960 MESH:D054463 NCI:C4924 OMIM:601675 UMLS_CUI:C1955934 IBIDS syndrome Tay syndrome sulfur-deficient brittle hair syndrome trichothiodystrophy trichothiodystrophy with congenital ichthyosis disease_ontology DOID:2960 OMIM mapping confirmed by DO. [SN]. photosensitive trichothiodystrophy DOID:2962 An autosomal recessive disease that has material basis in rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. ICD10CM:Q87.1 MESH:D003057 NCI:C9460 OMIM:133540 OMIM:216400 OMIM:216411 ORDO:191 ORDO:90321 ORDO:90322 ORDO:90324 SNOMEDCT_US_2016_03_01:205832003 SNOMEDCT_US_2016_03_01:21086008 UMLS_CUI:C0009207 Neill-Dingwall syndrome disease_ontology Cockayne's syndrome DOID:2962 Xref MGI. OMIM mapping confirmed by DO. [SN]. Cockayne syndrome DOID:2965 ICD10CM:M71.9 MESH:D002062 NCI:C94407 SNOMEDCT_US_2016_03_01:156677003 SNOMEDCT_US_2016_03_01:156686008 SNOMEDCT_US_2016_03_01:202935009 SNOMEDCT_US_2016_03_01:268000007 SNOMEDCT_US_2016_03_01:84017003 UMLS_CUI:C0006444 disease_ontology DOID:2965 bursitis DOID:2975 MESH:D052177 UMLS_CUI:C0022679 KIDNEY CYST renal Cyst disease_ontology DOID:2975 cystic kidney disease DOID:2978 An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates. DOID:9434 ICD9CM:271.8 MESH:D002239 UMLS_CUI:C0007001 UMLS_CUI:C0029777 disorder of carbohydrate transport and metabolism inborn carbohydrate metabolism disorder inborn errors of carbohydrate metabolism disease_ontology DOID:2978 carbohydrate metabolic disorder DOID:2987 A hypersensitivity reaction type II disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has material basis in mutations in the MEFV gene, which encodes the protein pyrin. ICD10CM:E85.0 ICD9CM:277.31 MESH:D010505 NCI:C84707 OMIM:134610 OMIM:249100 ORDO:342 SNOMEDCT_US_2016_03_01:12579009 UMLS_CUI:C0031069 benign paroxysmal peritonitis disease_ontology DOID:2987 Xref MGI. OMIM mapping confirmed by DO. [SN]. familial Mediterranean fever DOID:299 A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue. CSP:2000-0386 MESH:D000230 NCI:C2852 SNOMEDCT_US_2016_03_01:189578007 SNOMEDCT_US_2016_03_01:189582009 SNOMEDCT_US_2016_03_01:35917007 SNOMEDCT_US_2016_03_01:443961001 UMLS_CUI:C0001418 adenocarcinoma NOS (morphologic abnormality) adenocarcinoma, no subtype (morphologic abnormality) adenocarcinomas disease_ontology DOID:299 adenocarcinoma DOID:2994 A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells. DOID:2157 MESH:D009373 NCI:C3708 SNOMEDCT_US_2016_03_01:115233005 SNOMEDCT_US_2016_03_01:189839002 SNOMEDCT_US_2016_03_01:189854008 SNOMEDCT_US_2016_03_01:28307001 SNOMEDCT_US_2016_03_01:302853003 SNOMEDCT_US_2016_03_01:402878003 UMLS_CUI:C0205851 malignant tumor of the germ cell disease_ontology germ cell neoplasm germ cell tumour DOID:2994 germ cell cancer DOID:2997 MESH:D018310 SNOMEDCT_US_2016_03_01:34110004 UMLS_CUI:C0206723 disease_ontology DOID:2997 Sertoli-Leydig cell tumor DOID:2998 A male reproductive system cancer that is located_in the testicles. DOID:12231 DOID:5554 ICD10CM:C62 ICD10CM:C62.9 ICD10CM:C62.90 ICD9CM:186 MESH:D013736 NCI:C3404 NCI:C5053 NCI:C7251 OMIM:273300 SNOMEDCT_US_2016_03_01:126900000 SNOMEDCT_US_2016_03_01:188228003 SNOMEDCT_US_2016_03_01:236778008 SNOMEDCT_US_2016_03_01:269472003 SNOMEDCT_US_2016_03_01:363449006 SNOMEDCT_US_2016_03_01:94087009 UMLS_CUI:C0039590 UMLS_CUI:C0153594 UMLS_CUI:C1333010 childhood neoplasm of the testis neoplasm of testis (disorder) pediatric testicular neoplasm testicular tumor testicular tumor (disorder) testis cancer testis neoplasm disease_ontology DOID:2998 OMIM mapping confirmed by DO. [SN]. testicular cancer DOID:2999 DOID:5333 MESH:D006106 NCI:C3070 NCI:C4205 SNOMEDCT_US_2016_03_01:18861007 SNOMEDCT_US_2016_03_01:189734000 SNOMEDCT_US_2016_03_01:46585005 UMLS_CUI:C0018206 UMLS_CUI:C0334401 Granulosa cell neoplasm Granulosa cell tumor, adult type (morphologic abnormality) Granulosa cell tumour, sarcomatoid malignant granulosa cell neoplasm disease_ontology DOID:2999 granulosa cell tumor DOID:3007 A breast carcinoma that derives_from the lining of milk ducts. MESH:D044584 SNOMEDCT_US_2016_03_01:82711006 UMLS_CUI:C1176475 duct carcinoma, NOS disease_ontology DOID:3007 breast ductal carcinoma DOID:3008 DOID:3005 MESH:D018270 NCI:C4017 NCI:C4194 SNOMEDCT_US_2016_03_01:408643008 SNOMEDCT_US_2016_03_01:58477004 UMLS_CUI:C1134719 UMLS_CUI:C1527349 Infiltrating ductal carcinoma of breast Invasive ductal carcinoma, NST ductal adenocarcinoma disease_ontology DOID:3008 invasive ductal carcinoma DOID:3010 NCI:C27939 UMLS_CUI:C0861352 Lobular Intraepithelial Neoplasia lobular carcinoma in situ disease_ontology DOID:3010 lobular neoplasia DOID:3012 An autosomal dominant disease characterized by increases risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata. MESH:D016864 NCI:C3476 OMIM:151623 OMIM:609265 OMIM:609266 ORDO:524 SNOMEDCT_US_2016_03_01:428850001 UMLS_CUI:C0085390 Li-Fraumeni Familiar cancer Susceptibility syndrome SBLA syndrome sarcoma, breast, leukaemia and adrenal gland syndrome disease_ontology DOID:3012 Xref MGI. OMIM mapping confirmed by DO. [SN]. Li-Fraumeni syndrome DOID:302 A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. MESH:D019966 NCI:C16522 SNOMEDCT_US_2016_03_01:26416006 UMLS_CUI:C0013146 disease_ontology DOID:302 substance abuse DOID:303 A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. MESH:D019966 NCI:C92203 UMLS_CUI:C0236969 disease_ontology DOID:303 substance-related disorder DOID:3039 A cecum carcinoma that derives_from epithelial cells of glandular origin. NCI:C5543 SNOMEDCT_US_2016_03_01:413446001 UMLS_CUI:C1332866 Cecal adenocarcinoma adenocarcinoma of cecum (disorder) disease_ontology adenocarcinoma of cecum DOID:3039 cecum adenocarcinoma DOID:3042 A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign. ICD10CM:L23 ICD10CM:L23.9 MESH:D017449 NCI:C26998 SNOMEDCT_US_2016_03_01:200841005 SNOMEDCT_US_2016_03_01:238575004 UMLS_CUI:C0162820 Allergic Contact Dermatitis Allergic contact dermatitis Allergic contact dermatitis (disorder) disease_ontology DOID:3042 allergic contact dermatitis DOID:3044 A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system. MESH:D005512 SNOMEDCT_US_2016_03_01:157801005 SNOMEDCT_US_2016_03_01:213018006 SNOMEDCT_US_2016_03_01:414285001 SNOMEDCT_US_2016_03_01:52332009 UMLS_CUI:C0016470 food hypersensitivity disease_ontology DOID:3044 food allergy DOID:305 A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. DOID:2428 DOID:6570 CSP:2000-1867 MESH:D002277 MESH:D009375 NCI:C2916 NCI:C3709 SNOMEDCT_US_2016_03_01:118285006 SNOMEDCT_US_2016_03_01:134207000 SNOMEDCT_US_2016_03_01:154433003 SNOMEDCT_US_2016_03_01:188083002 SNOMEDCT_US_2016_03_01:189546004 SNOMEDCT_US_2016_03_01:189549006 SNOMEDCT_US_2016_03_01:189559007 SNOMEDCT_US_2016_03_01:269513004 SNOMEDCT_US_2016_03_01:68453008 SNOMEDCT_US_2016_03_01:71298006 UMLS_CUI:C0007097 UMLS_CUI:C0553707 UMLS_CUI:C1368683 epithelioma malignant Epithelioma disease_ontology DOID:305 carcinoma DOID:3068 An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes. DOID:3075 DOID:3080 MESH:D005909 NCI:C3058 NCI:C39750 NCI:C9094 SNOMEDCT_US_2016_03_01:189917003 SNOMEDCT_US_2016_03_01:269506004 SNOMEDCT_US_2016_03_01:63634009 UMLS_CUI:C0017636 UMLS_CUI:C0278878 UMLS_CUI:C1514422 GBM GBM (Glioblastoma) adult glioblastoma multiforme grade IV adult Astrocytic tumor primary glioblastoma multiforme spongioblastoma multiforme disease_ontology DOID:3068 glioblastoma multiforme DOID:3069 A malignant glioma that is has_material_basis_in astocyte cells, a type of star-shaped glial cell, located_in the cerebrum. DOID:4861 MESH:D001254 NCI:C4951 NCI:C60781 NCI:C6958 SNOMEDCT_US_2016_03_01:189914005 SNOMEDCT_US_2016_03_01:38713004 SNOMEDCT_US_2016_03_01:99131000119108 UMLS_CUI:C0004114 UMLS_CUI:C0750935 Astrocytic tumor astrocytoma of Cerebrum astrocytoma of brain (disorder) astrocytoma, no ICD-O subtype (morphologic abnormality) astroglioma cerebral astrocytoma disease_ontology DOID:3069 astrocytoma DOID:3070 A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine. DOID:2627 KEGG:05214 MESH:D005910 NCI:C3059 NCI:C4822 OMIM:137800 OMIM:607248 OMIM:613028 OMIM:613029 OMIM:613030 OMIM:613031 OMIM:613032 OMIM:613033 ORDO:182067 SNOMEDCT_US_2016_03_01:115240006 SNOMEDCT_US_2016_03_01:189908003 SNOMEDCT_US_2016_03_01:189909006 SNOMEDCT_US_2016_03_01:189926000 SNOMEDCT_US_2016_03_01:269505000 SNOMEDCT_US_2016_03_01:393564001 SNOMEDCT_US_2016_03_01:416500007 SNOMEDCT_US_2016_03_01:74532006 UMLS_CUI:C0017638 UMLS_CUI:C0555198 Gliomas (morphologic abnormality) Neuroglial tumor glial cell tumor glioma glioma (morphologic abnormality) glioma NOS glioma NOS (morphologic abnormality) glioma, NOS glioma, malignant glioma, malignant, no ICD-O subtype malignant Neuroglial tumor malignant glioma (morphologic abnormality) malignant glioma - category disease_ontology DOID:3070 Xref MGI. OMIM mapping confirmed by DO. [SN]. malignant glioma DOID:308 MESH:D004831 SNOMEDCT_US_2016_03_01:192847001 SNOMEDCT_US_2016_03_01:192992007 SNOMEDCT_US_2016_03_01:37356005 UMLS_CUI:C0014550 Epileptic seizures - myoclonic (disorder) Epileptic seizures, myoclonic Myoclonic seizure Myoclonic seizure disorder myoclonia epileptica myoclonic epilepsy disease_ontology DOID:308 early myoclonic encephalopathy DOID:3081 MESH:D018191 NCI:C3724 SNOMEDCT_US_2016_03_01:399882002 SNOMEDCT_US_2016_03_01:40225001 SNOMEDCT_US_2016_03_01:423984004 UMLS_CUI:C0206620 cystic Hygroma disease_ontology DOID:3081 cystic lymphangioma DOID:3082 ICD10CM:J84.9 MESH:D017563 SNOMEDCT_US_2016_03_01:233703007 SNOMEDCT_US_2016_03_01:64667001 UMLS_CUI:C0206062 ILD disease_ontology DOID:3082 interstitial lung disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 SNOMEDCT_US_2016_03_01:13645005 SNOMEDCT_US_2016_03_01:155565006 SNOMEDCT_US_2016_03_01:155569000 SNOMEDCT_US_2016_03_01:155585005 SNOMEDCT_US_2016_03_01:155617000 SNOMEDCT_US_2016_03_01:195935004 SNOMEDCT_US_2016_03_01:195948000 SNOMEDCT_US_2016_03_01:196003006 SNOMEDCT_US_2016_03_01:413846005 UMLS_CUI:C0024117 COLD (chronic obstructive lung disease) COPD chronic obstructive airway disease chronic obstructive lung disease disease_ontology DOID:3083 chronic obstructive pulmonary disease DOID:3086 ICD10CM:K06.1 MESH:D019214 SNOMEDCT_US_2016_03_01:196375006 SNOMEDCT_US_2016_03_01:271083000 SNOMEDCT_US_2016_03_01:54711002 UMLS_CUI:C0376480 Gingival enlargement (disorder) Gingival enlargement NOS Gingival enlargement NOS (disorder) disease_ontology DOID:3086 gingival overgrowth DOID:3093 An organ system cancer located_in the nervous system that affects the central or peripheral nervous system. DOID:1193 DOID:3195 DOID:4695 ICD9CM:192 ICD9CM:192.9 MESH:D009380 NCI:C35562 SNOMEDCT_US_2016_03_01:188306000 UMLS_CUI:C0027665 UMLS_CUI:C0153643 UMLS_CUI:C1334956 malignant neoplasm of nervous system neoplasm of nervous system (disorder) nervous system neoplasm neural neoplasm neural tumor tumor of the nervous system disease_ontology DOID:3093 nervous system cancer DOID:3095 A germ cell cancer that is derives_from a mixture of germs cells and embryonal cells. MESH:D009373 UMLS_CUI:C0027658 disease_ontology germ cell and embryonal neoplasm DOID:3095 germ cell and embryonal cancer DOID:3098 MESH:D018228 NCI:C3746 SNOMEDCT_US_2016_03_01:73506006 UMLS_CUI:C0206652 disease_ontology DOID:3098 small cell sarcoma DOID:3111 An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed. MESH:D003536 NCI:C2971 SNOMEDCT_US_2016_03_01:189681005 SNOMEDCT_US_2016_03_01:21008007 UMLS_CUI:C0010631 cystadenocarcinoma (morphologic abnormality) cystadenocarcinoma NOS (morphologic abnormality) disease_ontology DOID:3111 cystadenocarcinoma DOID:3112 An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue. DOID:5596 MESH:D000231 NCI:C2853 NCI:C7438 SNOMEDCT_US_2016_03_01:189621008 SNOMEDCT_US_2016_03_01:4797003 SNOMEDCT_US_2016_03_01:64524002 UMLS_CUI:C0001420 UMLS_CUI:C1321863 Infiltrating and papillary adenocarcinoma Papillary adenocarcinoma Papillary adenocarcinoma (morphologic abnormality) Papillary adenocarcinoma NOS (morphologic abnormality) infiltrating papillary adenocarcinoma disease_ontology DOID:3112 papillary adenocarcinoma DOID:3113 A carcinoma that is derives_from epithelial cells with finger like projections. MESH:D002291 NCI:C2927 SNOMEDCT_US_2016_03_01:189562005 SNOMEDCT_US_2016_03_01:25910003 UMLS_CUI:C0007133 Papillary carcinoma Papillary carcinoma (morphologic abnormality) Papillary carcinoma NOS (morphologic abnormality) disease_ontology DOID:3113 papillary carcinoma DOID:3116 NCI:C7514 UMLS_CUI:C1334323 renal and ureteral tumor disease_ontology DOID:3116 kidney benign neoplasm DOID:3117 A gastrointestinal system benign neoplasm located_in the hepatobiliary system. NCI:C8614 UMLS_CUI:C0854196 hepatobiliary tumors disease_ontology DOID:3117 hepatobiliary benign neoplasm DOID:3118 A gastrointestinal system disease that is located_in the liver and/or biliary tract. NCI:C3959 UMLS_CUI:C0267792 liver and biliary tract disease disease_ontology DOID:3118 hepatobiliary disease DOID:3119 An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system. DOID:4945 DOID:8377 ICD10CM:C26.9 ICD9CM:239.0 MESH:D004067 MESH:D005770 NCI:C3052 NCI:C4890 SNOMEDCT_US_2016_03_01:126768004 SNOMEDCT_US_2016_03_01:128348002 SNOMEDCT_US_2016_03_01:128415001 SNOMEDCT_US_2016_03_01:189527000 SNOMEDCT_US_2016_03_01:276806006 SNOMEDCT_US_2016_03_01:367543008 SNOMEDCT_US_2016_03_01:428905002 SNOMEDCT_US_2016_03_01:93811007 UMLS_CUI:C0012243 UMLS_CUI:C0017185 UMLS_CUI:C0685938 GI tumor digestive system cancer gastrointestinal tract cancer disease_ontology DOID:3119 gastrointestinal system cancer DOID:3121 A biliary tract cancer that is located_in the gallbladder. DOID:8090 DOID:8157 ICD10CM:C23 ICD9CM:156.0 MESH:D005706 NCI:C3048 NCI:C35676 NCI:C7481 SNOMEDCT_US_2016_03_01:126854002 SNOMEDCT_US_2016_03_01:154472004 SNOMEDCT_US_2016_03_01:187782001 SNOMEDCT_US_2016_03_01:254602009 SNOMEDCT_US_2016_03_01:269550003 SNOMEDCT_US_2016_03_01:363353009 SNOMEDCT_US_2016_03_01:93810008 UMLS_CUI:C0016978 UMLS_CUI:C0153452 UMLS_CUI:C0278806 gallbladder Ca gallbladder neoplasm localized malignant gallbladder neoplasm malignant neoplasm of gallbladder malignant tumor of the gallbladder malignant tumour of gallbladder tumor of the gallbladder disease_ontology DOID:3121 gallbladder cancer DOID:3122 MESH:D017219 SNOMEDCT_US_2016_03_01:196759006 SNOMEDCT_US_2016_03_01:244815007 UMLS_CUI:C0162651 gastric outflow obstruction disease_ontology DOID:3122 gastric outlet obstruction DOID:3133 A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis. MESH:D017094 OMIM:612740 ORDO:100924 SNOMEDCT_US_2016_03_01:55056006 UMLS_CUI:C0162533 hepatic porphyria (disorder) disease_ontology DOID:3133 Xref MGI. acute porphyria DOID:3138 ICD10CM:L83 MESH:D000052 NCI:C26687 OMIM:100600 OMIM:200170 SNOMEDCT_US_2016_03_01:402599005 SNOMEDCT_US_2016_03_01:72129000 UMLS_CUI:C0000889 AN - Acanthosis nigricans Acanthosis nigricans (disorder) Keratosis nigricans keratosis nigricans disease_ontology DOID:3138 OMIM mapping confirmed by DO. [SN]. acanthosis nigricans DOID:314 ICD9CM:727.02 NCI:C3402 SNOMEDCT_US_2016_03_01:128777004 SNOMEDCT_US_2016_03_01:310605004 SNOMEDCT_US_2016_03_01:71508003 SNOMEDCT_US_2016_03_01:95412009 SNOMEDCT_US_2016_03_01:95413004 UMLS_CUI:C1318543 Giant cell tumor of Tenosynovium Giant cell tumor of tendon sheath fibrous histiocytoma of tendon sheath (disorder) disease_ontology DOID:314 tenosynovial giant cell tumor DOID:3146 An inherited metabolic disorder that involves the creation and degradation of lipids. MESH:D008052 UMLS_CUI:C0023772 dyslipidemia fatty acid metabolism disorder disease_ontology DOID:3146 lipid metabolism disorder DOID:3151 A skin carcinoma that has_material_basis_in squamous cells. NCI:C4819 SNOMEDCT_US_2016_03_01:254651007 UMLS_CUI:C0553723 Epidermoid skin carcinoma disease_ontology squamous cell carcinoma of skin DOID:3151 skin squamous cell carcinoma DOID:3153 ICD10CM:E88.2 MESH:D008068 SNOMEDCT_US_2016_03_01:37095002 SNOMEDCT_US_2016_03_01:402693001 UMLS_CUI:C0023801 disease_ontology DOID:3153 lipomatosis DOID:3156 MESH:D010859 NCI:C7582 SNOMEDCT_US_2016_03_01:218358001 SNOMEDCT_US_2016_03_01:254202001 SNOMEDCT_US_2016_03_01:254816001 SNOMEDCT_US_2016_03_01:367520004 SNOMEDCT_US_2016_03_01:48543002 SNOMEDCT_US_2016_03_01:806001 UMLS_CUI:C0022283 Bloch-Siemans syndrome Hypomelanosis of Ito Incontinentia pigmenti achromians syndrome Incontinentia pigmenti syndrome Ito's nevus nevus of Ito disease_ontology DOID:3156 incontinentia pigmenti achromians DOID:3165 MESH:D012878 NCI:C3372 SNOMEDCT_US_2016_03_01:126488004 SNOMEDCT_US_2016_03_01:363230005 UMLS_CUI:C0037286 neoplasm of skin (disorder) neoplasm of skin by site skin neoplasm tumor of the skin disease_ontology DOID:3165 skin benign neoplasm DOID:3178 NCI:C4614 SNOMEDCT_US_2016_03_01:154613008 SNOMEDCT_US_2016_03_01:189051001 SNOMEDCT_US_2016_03_01:255184001 SNOMEDCT_US_2016_03_01:269639005 UMLS_CUI:C0347390 Cutaneous papilloma cutaneous papilloma papilloma of skin papilloma of skin (disorder) skin papilloma NOS disease_ontology DOID:3178 skin papilloma DOID:3179 MESH:D018308 NCI:C3793 SNOMEDCT_US_2016_03_01:104081000119103 UMLS_CUI:C0206721 Inverted papilloma Inverted papilloma, squamous cell disease_ontology DOID:3179 inverted papilloma DOID:3181 DOID:3182 MESH:D009837 NCI:C6960 UMLS_CUI:C0028945 UMLS_CUI:C1335110 oligodendroglial neoplasm oligodendroglial tumor disease_ontology DOID:3181 oligodendroglioma DOID:319 ICD10CM:G95.9 ICD9CM:336.9 MESH:D013118 NCI:C97110 SNOMEDCT_US_2016_03_01:155020007 SNOMEDCT_US_2016_03_01:192908002 SNOMEDCT_US_2016_03_01:192913003 SNOMEDCT_US_2016_03_01:267587000 SNOMEDCT_US_2016_03_01:267695005 SNOMEDCT_US_2016_03_01:48522003 SNOMEDCT_US_2016_03_01:95648003 UMLS_CUI:C0037928 disease_ontology myelopathy DOID:319 spinal cord disease DOID:3192 MESH:D009442 NCI:C3269 SNOMEDCT_US_2016_03_01:189948006 SNOMEDCT_US_2016_03_01:404022001 SNOMEDCT_US_2016_03_01:985004 UMLS_CUI:C0027809 Psammomatous schwannoma schwannoma disease_ontology DOID:3192 neurilemmoma DOID:3193 A peripheral nervous system neoplasm that is located_in the connective tissue surrounding nerves. MESH:D018317 UMLS_CUI:C0751689 neoplasm of the nerve Sheath nerve sheath tumour disease_ontology DOID:3193 peripheral nerve sheath neoplasm DOID:321 A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms. ICD10CM:G04.1 MESH:D015493 OMIM:159580 SNOMEDCT_US_2016_03_01:192733005 SNOMEDCT_US_2016_03_01:45129002 SNOMEDCT_US_2016_03_01:714279000 UMLS_CUI:C0030481 HTLV-associated myelopathy Tropical spastic paralysis Tropical spastic paraplegia disease_ontology DOID:321 OMIM mapping confirmed by DO. [LS]. tropical spastic paraparesis DOID:3210 A hypomyelinating leukodystrophy characterized by impaired myelin formation, nystagmus, spastic quadriplegia, ataxia, and developmental delay that has_material_basis_in mutation in the PLP1 gene on chromosome Xq22. ICD10CM:E75.2 MESH:D020371 NCI:C75487 OMIM:312080 ORDO:702 SNOMEDCT_US_2016_03_01:64855000 UMLS_CUI:C0205711 HLD1 Leukodystrophy, sudanophilic PMD Pelizaeus Merzbacher brain sclerosis Pelizaeus-Merzbacher brain sclerosis diffuse familial brain sclerosis hypomyelinating leukodystrophy 1 sudanophilic leukodystrophy, Paelizeus-Merzbacher type disease_ontology DOID:3210 Pelizaeus-Merzbacher disease DOID:3211 An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function. MESH:D016464 NCI:C61250 SNOMEDCT_US_2016_03_01:23585005 UMLS_CUI:C0085078 disorder of lysosomal enzyme (disorder) inborn lysosomal enzyme disorder lysosomal storage metabolism disorder disease_ontology DOID:3211 lysosomal storage disease DOID:3213 MESH:D003711 NCI:C34527 UMLS_CUI:C0011303 demyelinating disorder disease_ontology DOID:3213 demyelinating disease DOID:3223 MESH:D020918 SNOMEDCT_US_2016_03_01:128200000 UMLS_CUI:C0458219 Complex regional pain syndromes (disorder) disease_ontology DOID:3223 complex regional pain syndrome DOID:3225 ICD10CM:S12.8 MESH:D014133 NCI:C35079 SNOMEDCT_US_2016_03_01:47125007 UMLS_CUI:C0040580 disease_ontology DOID:3225 tracheal disease DOID:3230 MESH:D006610 UMLS_CUI:C0019537 disease_ontology DOID:3230 high pressure neurological syndrome DOID:3247 A skeletal muscle cancer that arise from skeletal muscle progenitors. MESH:D012208 NCI:C3359 SNOMEDCT_US_2016_03_01:134166003 SNOMEDCT_US_2016_03_01:302847003 SNOMEDCT_US_2016_03_01:30924005 UMLS_CUI:C0035412 disease_ontology DOID:3247 rhabdomyosarcoma DOID:326 A vascular disease that is characterized by a restriction in blood supply to tissues. MESH:D007511 MESH:D054058 NCI:C34738 SNOMEDCT_US_2016_03_01:52674009 UMLS_CUI:C0022116 disease_ontology DOID:326 ischemia DOID:3261 MESH:D007589 OMIM:147060 UMLS_CUI:C1968689 UMLS_CUI:C2936739 Job syndrome hyperimmunoglobulin E syndrome disease_ontology DOID:3261 OMIM mapping confirmed by DO. [SN]. Job's syndrome DOID:3262 A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection. MESH:D010585 UMLS_CUI:C0031306 phagocytic dysfunction disease_ontology DOID:3262 phagocyte bactericidal dysfunction DOID:3263 ICD10CM:E70.39 MESH:D016116 NCI:C85009 OMIM:172800 SNOMEDCT_US_2016_03_01:6479008 UMLS_CUI:C0080024 PIEBALD TRAIT Partial albinism (disorder) disease_ontology DOID:3263 OMIM mapping confirmed by DO. [SN]. piebaldism DOID:3265 A phagocyte bactericidal dysfunction characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones may occur along with swollen areas of inflamed tissues known as granulomas that can be widely distributed. ICD10CM:D71 MESH:D006105 NCI:C26788 OMIM:138990 OMIM:233690 OMIM:233700 OMIM:233710 OMIM:306400 OMIM:613960 ORDO:379 SNOMEDCT_US_2016_03_01:11210002 SNOMEDCT_US_2016_03_01:191352003 SNOMEDCT_US_2016_03_01:191354002 SNOMEDCT_US_2016_03_01:387759001 UMLS_CUI:C0018203 Bridges-Good syndrome CGD Congenital dysphagocytosis Quie syndrome disease_ontology DOID:3265 Xref MGI. OMIM mapping confirmed by DO. [SN]. chronic granulomatous disease DOID:3275 A thymus cancer that derives_from epithelial cells located_in the thymus. The tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus. MESH:D013945 NCI:C3411 SNOMEDCT_US_2016_03_01:128856005 SNOMEDCT_US_2016_03_01:189721001 SNOMEDCT_US_2016_03_01:444231005 UMLS_CUI:C0040100 disease_ontology DOID:3275 thymoma DOID:3277 An immune system cancer located_in the thymus. DOID:10143 ICD10CM:C37 ICD9CM:164.0 MESH:D013953 NCI:C4962 SNOMEDCT_US_2016_03_01:363434003 SNOMEDCT_US_2016_03_01:94096009 UMLS_CUI:C0751552 Thymic tumor neoplasm of thymus (disorder) thymic neoplasm disease_ontology DOID:3277 thymus cancer DOID:3298 A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches. MESH:D014615 SNOMEDCT_US_2016_03_01:111852003 UMLS_CUI:C0042214 disease_ontology DOID:3298 vaccinia DOID:3301 A cell type benign neoplasm that is composed_of a mixture of gonadal elements. MESH:D018238 NCI:C3754 OMIM:424500 SNOMEDCT_US_2016_03_01:74751003 UMLS_CUI:C0206661 disease_ontology DOID:3301 OMIM mapping confirmed by DO. [SN]. gonadoblastoma DOID:3305 A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both. MESH:D018243 NCI:C3756 SNOMEDCT_US_2016_03_01:67830002 UMLS_CUI:C0206664 Teratocarcinoma (morphologic abnormality) mixed Embryonal carcinoma and teratoma disease_ontology DOID:3305 teratocarcinoma DOID:3306 A germ cell cancer that occurs in many forms. NCI:C4290 NCI:C9010 SNOMEDCT_US_2016_03_01:189853002 SNOMEDCT_US_2016_03_01:32844007 UMLS_CUI:C0334524 mixed germ cell neoplasm mixed germ cell tumour mixed teratoma and Seminoma mixed teratoma and seminoma disease_ontology DOID:3306 mixed germ cell cancer DOID:3307 A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers. MESH:D013724 NCI:C3403 SNOMEDCT_US_2016_03_01:189844009 SNOMEDCT_US_2016_03_01:189846006 SNOMEDCT_US_2016_03_01:189848007 SNOMEDCT_US_2016_03_01:55818009 UMLS_CUI:C0039538 Teratomas (morphologic abnormality) disease_ontology DOID:3307 teratoma DOID:331 A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system. ICD10CM:G96.9 MESH:D002493 NCI:C2934 SNOMEDCT_US_2016_03_01:138748005 SNOMEDCT_US_2016_03_01:154981003 SNOMEDCT_US_2016_03_01:155049004 SNOMEDCT_US_2016_03_01:155059003 SNOMEDCT_US_2016_03_01:192641002 SNOMEDCT_US_2016_03_01:193076009 SNOMEDCT_US_2016_03_01:194566008 SNOMEDCT_US_2016_03_01:23853001 SNOMEDCT_US_2016_03_01:267144009 SNOMEDCT_US_2016_03_01:267679005 SNOMEDCT_US_2016_03_01:267700003 SNOMEDCT_US_2016_03_01:267702006 SNOMEDCT_US_2016_03_01:275539005 UMLS_CUI:C0007682 disease_ontology DOID:331 central nervous system disease DOID:3310 A dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking. EFO:0000274 ICD10CM:L20 ICD10CM:L20.81 ICD10CM:L20.9 MESH:D003876 OMIM:603165 OMIM:PS603165 SNOMEDCT_US_2016_03_01:156331003 SNOMEDCT_US_2016_03_01:200772001 SNOMEDCT_US_2016_03_01:200775004 SNOMEDCT_US_2016_03_01:200779005 SNOMEDCT_US_2016_03_01:24079001 UMLS_CUI:C0011615 Allergic (intrinsic) eczema (disorder) Atopic dermatitis Atopic dermatitis (disorder) Atopic dermatitis NOS (disorder) Atopic neurodermatitis (disorder) Besnier's prurigo Besnier's prurigo (disorder) allergic dermatitis atopic eczema disease_ontology DOID:3310 Xref MGI. OMIM mapping confirmed by DO. [SN]. atopic dermatitis DOID:3312 A mood disorder that involves alternating periods of mania and depression. DOID:3311 DOID:9554 DOID:9555 EFO:0000289 ICD10CM:F31 ICD10CM:F31.9 ICD9CM:296.40 ICD9CM:296.60 ICD9CM:296.80 MESH:D001714 NCI:C34423 NCI:C34424 NCI:C34805 SNOMEDCT_US_2016_03_01:13746004 SNOMEDCT_US_2016_03_01:154871001 SNOMEDCT_US_2016_03_01:16506000 SNOMEDCT_US_2016_03_01:191627008 SNOMEDCT_US_2016_03_01:191646009 SNOMEDCT_US_2016_03_01:191647000 SNOMEDCT_US_2016_03_01:191654006 SNOMEDCT_US_2016_03_01:192355004 SNOMEDCT_US_2016_03_01:192365005 SNOMEDCT_US_2016_03_01:268749008 SNOMEDCT_US_2016_03_01:68569003 UMLS_CUI:C0005586 UMLS_CUI:C0005587 UMLS_CUI:C0024713 UMLS_CUI:C0236780 Manic Bipolar Affective disorder Manic Depressive disorder Manic bipolar I disorder bipolar depression bipolar disorder manic phase manic depression manic disorder mixed bipolar disorder disease_ontology Depressive-manic psych. DOID:3312 bipolar disorder DOID:3314 A cell type benign neoplasm that from perivascular epithelioid cells. MESH:D018207 NCI:C3734 SNOMEDCT_US_2016_03_01:19929002 UMLS_CUI:C0206633 Angiomyolipoma (morphologic abnormality) disease_ontology DOID:3314 angiomyolipoma DOID:3315 A cell type benign neoplasm that is composed of lipocytes. DOID:3154 DOID:9291 ICD10CM:D17 ICD10CM:D17.9 ICD9CM:214 ICD9CM:214.9 MESH:D008067 MESH:D018205 NCI:C3192 NCI:C4248 NCI:C4502 OMIM:151900 SNOMEDCT_US_2016_03_01:115227001 SNOMEDCT_US_2016_03_01:154612003 SNOMEDCT_US_2016_03_01:189018005 SNOMEDCT_US_2016_03_01:189776008 SNOMEDCT_US_2016_03_01:189785008 SNOMEDCT_US_2016_03_01:254827004 SNOMEDCT_US_2016_03_01:254830006 SNOMEDCT_US_2016_03_01:254831005 SNOMEDCT_US_2016_03_01:46720004 SNOMEDCT_US_2016_03_01:93163002 UMLS_CUI:C0023798 UMLS_CUI:C0206631 UMLS_CUI:C0346118 LIPOMATOSIS, FAMILIAL MULTIPLE Lipomatous neoplasm (morphologic abnormality) Lipomatous tumor benign lipomatous tumor benign tumor of Adipose tissue multiple lipomatosis tumor of adipose tissue (disorder) disease_ontology DOID:3315 OMIM mapping confirmed by DO. [SN]. lipoma DOID:3319 DOID:3682 NCI:C38153 SNOMEDCT_US_2016_03_01:277844007 UMLS_CUI:C0349649 lung lymphangioleiomyomatosis lymphangiomyomatosis pulmonary lymphangioleiomyomatosis disease_ontology DOID:3319 lymphangioleiomyomatosis DOID:332 A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. EFO:0000253 ICD10CM:G12.21 ICD9CM:335.20 KEGG:05014 MESH:D000690 NCI:C34373 OMIM:PS105400 SNOMEDCT_US_2016_03_01:86044005 UMLS_CUI:C0002736 ALS Lou Gehrig's disease motor neuron disease, bulbar disease_ontology DOID:332 amyotrophic lateral sclerosis DOID:3324 A cognitive disorder that involves an excessive, irrational dread of everyday situations. EFO:0004247 ICD10CM:F30-F39 ICD10CM:F39 MESH:D019964 NCI:C92200 SNOMEDCT_US_2016_03_01:192348001 SNOMEDCT_US_2016_03_01:192391006 SNOMEDCT_US_2016_03_01:268713007 SNOMEDCT_US_2016_03_01:46206005 SNOMEDCT_US_2016_03_01:74421008 UMLS_CUI:C0525045 episodic mood disorder disease_ontology DOID:3324 Updating outdated UMLS CUI. mood disorder DOID:3331 MESH:D017034 SNOMEDCT_US_2016_03_01:230394006 UMLS_CUI:C0085541 Frontal lobe epilepsy (disorder) disease_ontology DOID:3331 frontal lobe epilepsy DOID:334 A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood. ICD10CM:F60.4 ICD9CM:301.5 ICD9CM:301.50 MESH:D006677 NCI:C92634 SNOMEDCT_US_2016_03_01:154900000 SNOMEDCT_US_2016_03_01:191764009 SNOMEDCT_US_2016_03_01:191767002 SNOMEDCT_US_2016_03_01:192489002 SNOMEDCT_US_2016_03_01:268758001 SNOMEDCT_US_2016_03_01:55341008 UMLS_CUI:C0019681 disease_ontology DOID:334 histrionic personality disorder DOID:3341 A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone. MESH:D010002 NCI:C34875 SNOMEDCT_US_2016_03_01:190451000 SNOMEDCT_US_2016_03_01:190453002 SNOMEDCT_US_2016_03_01:84727000 UMLS_CUI:C0029405 Osteitis fibrosa cystica generalisata (disorder) Von Recklinghausen's bone disease hyperparathyroid bone disease disease_ontology DOID:3341 osteitis fibrosa DOID:3342 A bone disease that results_in inflammation of the located_in bone. MESH:D010000 SNOMEDCT_US_2016_03_01:156780005 SNOMEDCT_US_2016_03_01:274144001 SNOMEDCT_US_2016_03_01:363172002 SNOMEDCT_US_2016_03_01:44462005 UMLS_CUI:C0029400 Inflammatory disorder of bone bone inflammatory disease osteitis disease_ontology DOID:3342 bone inflammation disease DOID:3343 A lysosomal storage disease that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase). ICD10:E77.1 MESH:D009081 NCI:C61267 OMIM:256550 SNOMEDCT_US_2016_03_01:70528007 UMLS_CUI:C0026697 Mucolipidosis type I sialidosis disease_ontology DOID:3343 OMIM mapping submitted by NeuroDevNet. [LS]. glycoproteinosis DOID:3345 A lipid storage disease that is characterized by the desposition of yellowish cholesterol-rich material in tendons or other body parts. MESH:D014973 SNOMEDCT_US_2016_03_01:63103006 UMLS_CUI:C0043325 xanthelasmatosis disease_ontology DOID:3345 xanthomatosis DOID:3347 A bone cancer that is located_in bone that has_material_basis_in cells of mesenchymal origin. DOID:183 MESH:D012516 MESH:D018213 NCI:C9145 OMIM:259500 SNOMEDCT_US_2016_03_01:189878003 SNOMEDCT_US_2016_03_01:21708004 SNOMEDCT_US_2016_03_01:307576001 SNOMEDCT_US_2016_03_01:408387006 UMLS_CUI:C0029463 UMLS_CUI:C0206639 Osteogenic sarcoma Skeletal sarcoma bone tissue neoplasm osteoid sarcoma disease_ontology DOID:3347 OMIM mapping confirmed by DO. [SN]. osteosarcoma DOID:3350 A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system. DOID:1630 NCI:C6587 NCI:C7059 UMLS_CUI:C1332517 UMLS_CUI:C1334699 benign miscellaneous mesenchymal tumor mesenchymal tumor disease_ontology DOID:3350 mesenchymal cell neoplasm DOID:3355 A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. DOID:156 DOID:3509 MESH:D005354 MESH:D018218 NCI:C3043 NCI:C6605 NCI:C7075 SNOMEDCT_US_2016_03_01:443250000 SNOMEDCT_US_2016_03_01:53654007 UMLS_CUI:C0016057 UMLS_CUI:C0206643 UMLS_CUI:C1336021 Fibrocytic tumor fibrosarcoma of soft tissue fibrous tissue neoplasm disease_ontology DOID:3355 fibrosarcoma DOID:3368 A peripheral primitive neuroectodermal tumor that is located_in bone. DOID:4984 DOID:6392 NCI:C35871 NCI:C4835 NCI:C6623 SNOMEDCT_US_2016_03_01:307608006 UMLS_CUI:C0585474 UMLS_CUI:C1333481 UMLS_CUI:C1334406 Ewing's sarcoma/bone peripheral primitive neuroectodermal tumor bone Ewing sarcoma bone localized Ewing sarcoma bone localized Ewing's sarcoma localized Skeletal Ewing's sarcoma disease_ontology Ewing's sarcoma of bone Skeletal Ewing's tumor bone Ewing's sarcoma DOID:3368 bone Ewing's sarcoma DOID:3369 A bone cancer that has_material_basis in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm. DOID:0050607 DOID:4158 DOID:4390 DOID:4391 DOID:4392 DOID:4980 MESH:C563168 MESH:D012512 MESH:D018241 NCI:C27901 NCI:C27903 NCI:C4817 NCI:C7542 NCI:C7806 NCI:C9341 OMIM:612219 SNOMEDCT_US_2016_03_01:128783001 SNOMEDCT_US_2016_03_01:134210007 SNOMEDCT_US_2016_03_01:253096008 SNOMEDCT_US_2016_03_01:703707001 SNOMEDCT_US_2016_03_01:73506006 SNOMEDCT_US_2016_03_01:73676002 SNOMEDCT_US_2016_03_01:76909002 UMLS_CUI:C0553580 UMLS_CUI:C0684337 UMLS_CUI:C0796547 UMLS_CUI:C0863029 UMLS_CUI:C0877849 UMLS_CUI:C1334408 Ewing's family localized tumor Ewing's sarcoma/peripheral primitive neuroectodermal tumor Ewing's tumor Ewings sarcoma Ewings sarcoma-primitive neuroectodermal tumor PNET of Thoracopulmonary Region localized Ewing sarcoma localized Ewing's sarcoma localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor localized Ewing's tumor localized peripheral primitive neuroectodermal tumor peripheral primitive neuroectodermal tumor disease_ontology DOID:3369 OMIM mapping confirmed by DO. [SN]. Ewing sarcoma DOID:3371 A connective tissue cancer that has_material_basis_in cells derived from transformed cells that produce cartilage. DOID:3370 MESH:D002813 NCI:C2946 NCI:C7155 OMIM:215300 SNOMEDCT_US_2016_03_01:14990007 SNOMEDCT_US_2016_03_01:189886003 SNOMEDCT_US_2016_03_01:443520009 UMLS_CUI:C0008479 UMLS_CUI:C1335473 chondrosarcoma of bone primary chondrosarcoma of the bone disease_ontology DOID:3371 OMIM mapping confirmed by DO. [SN]. chondrosarcoma DOID:338 cranial nerve neoplasm DOID:3382 A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum. MESH:D008080 NCI:C3194 SNOMEDCT_US_2016_03_01:189777004 SNOMEDCT_US_2016_03_01:254829001 SNOMEDCT_US_2016_03_01:49430005 UMLS_CUI:C0023827 disease_ontology DOID:3382 liposarcoma DOID:3388 ICD10CM:K05.6 MESH:D010510 NCI:C63743 SNOMEDCT_US_2016_03_01:13877006 SNOMEDCT_US_2016_03_01:196354003 SNOMEDCT_US_2016_03_01:2556008 UMLS_CUI:C0031090 Periodontal disease Periodontal disease (disorder) disease of supporting structures of teeth, NOS periodontium disorder disease_ontology DOID:3388 periodontal disease DOID:3390 A keratosis characterized by abnormal thickening of the palms and the soles. ICD10CM:L85.2 MESH:D007645 NCI:C34748 SNOMEDCT_US_2016_03_01:205584004 SNOMEDCT_US_2016_03_01:28596004 SNOMEDCT_US_2016_03_01:706885006 UMLS_CUI:C0022596 Keratosis palmaris et plantaris Palmoplantar Keratoderma disease_ontology DOID:3390 palmoplantar keratosis DOID:3393 An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.1 ICD10CM:I25.10 ICD10CM:I25.9 ICD10CM:K76.1 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:608901 OMIM:610938 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 OMIM:614466 SNOMEDCT_US_2016_03_01:155303000 SNOMEDCT_US_2016_03_01:155315001 SNOMEDCT_US_2016_03_01:155316000 SNOMEDCT_US_2016_03_01:155318004 SNOMEDCT_US_2016_03_01:155322009 SNOMEDCT_US_2016_03_01:194795001 SNOMEDCT_US_2016_03_01:194841001 SNOMEDCT_US_2016_03_01:194852007 SNOMEDCT_US_2016_03_01:194878003 SNOMEDCT_US_2016_03_01:195540001 SNOMEDCT_US_2016_03_01:233822007 SNOMEDCT_US_2016_03_01:2610009 SNOMEDCT_US_2016_03_01:266231003 SNOMEDCT_US_2016_03_01:266290000 SNOMEDCT_US_2016_03_01:266291001 SNOMEDCT_US_2016_03_01:271430002 SNOMEDCT_US_2016_03_01:32598000 SNOMEDCT_US_2016_03_01:413838009 SNOMEDCT_US_2016_03_01:413844008 SNOMEDCT_US_2016_03_01:414545008 SNOMEDCT_US_2016_03_01:414795007 SNOMEDCT_US_2016_03_01:41702007 SNOMEDCT_US_2016_03_01:443502000 SNOMEDCT_US_2016_03_01:53741008 SNOMEDCT_US_2016_03_01:84537008 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694 CHD (coronary heart disease) Coronary disease coronary arteriosclerosis coronary heart disease disease_ontology DOID:3393 Xref MGI. coronary artery disease DOID:3401 ICD10CM:E22.2 MESH:D007177 NCI:C3988 SNOMEDCT_US_2016_03_01:389983008 SNOMEDCT_US_2016_03_01:55004003 UMLS_CUI:C0021141 syndrome of Inappropriate Antidiuretic Hormone Secretion syndrome of inappropriate secretion of ADH syndrome of inappropriate secretion of antidiuretic hormone syndrome of inappropriate vasopressin secretion (disorder) disease_ontology DOID:3401 inappropriate ADH syndrome DOID:3405 A lymphatic system disease that is characterized by an excessive number of histiocytes. DOID:3344 MESH:D015614 NCI:C3106 SNOMEDCT_US_2016_03_01:190957008 SNOMEDCT_US_2016_03_01:60657004 SNOMEDCT_US_2016_03_01:65396000 UMLS_CUI:C0019618 Hand Schuller Christian disease chronic Histiocytosis X disease_ontology DOID:3405 histiocytosis DOID:3407 MESH:D002340 NCI:C84476 SNOMEDCT_US_2016_03_01:371160000 UMLS_CUI:C0007273 disorder of carotid artery (disorder) disease_ontology DOID:3407 carotid artery disease DOID:341 A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain. DOID:2868 ICD9CM:443.81 MESH:D001157 MESH:D016481 SNOMEDCT_US_2016_03_01:195624006 SNOMEDCT_US_2016_03_01:2929001 UMLS_CUI:C0003838 UMLS_CUI:C0031115 arterial occlusive disease disease_ontology DOID:341 peripheral vascular disease DOID:3410 MESH:D002341 SNOMEDCT_US_2016_03_01:195181000 SNOMEDCT_US_2016_03_01:86003009 UMLS_CUI:C0007274 Carotid artery thrombosis Carotid artery thrombosis (disorder) disease_ontology DOID:3410 carotid artery thrombosis DOID:342 ICD9CM:442.82 SNOMEDCT_US_2016_03_01:40136003 UMLS_CUI:C0155746 disease_ontology DOID:342 subclavian artery aneurysm DOID:3426 ICD10CM:H81 ICD10CM:H81.9 ICD10CM:H81.90 MESH:D015837 SNOMEDCT_US_2016_03_01:194379003 SNOMEDCT_US_2016_03_01:194695008 SNOMEDCT_US_2016_03_01:20425006 SNOMEDCT_US_2016_03_01:267761002 UMLS_CUI:C0042594 Vertigo, vestibular disorder disease_ontology DOID:3426 vestibular disease DOID:3443 NCI:C7073 UMLS_CUI:C1368019 Paget cell neoplasm Paget's disease Paget's disease of the breast mammary Paget disease disease_ontology DOID:3443 mammary Paget's disease DOID:345 A female reproductive system disease that is located_in the uterus. ICD10CM:N85.9 ICD9CM:621.9 MESH:D014591 NCI:C26907 SNOMEDCT_US_2016_03_01:12337004 SNOMEDCT_US_2016_03_01:156004005 SNOMEDCT_US_2016_03_01:156009000 SNOMEDCT_US_2016_03_01:198335006 SNOMEDCT_US_2016_03_01:237068005 UMLS_CUI:C0042131 disease_ontology DOID:345 uterine disease DOID:3451 A skin cancer that is located_in tissues of the skin and develops from epithelial cells. NCI:C4914 UMLS_CUI:C0699893 carcinoma of skin disease_ontology carcinoma of skin DOID:3451 skin carcinoma DOID:3454 MESH:D020520 UMLS_CUI:C0751955 disease_ontology DOID:3454 brain infarction DOID:3458 A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast. NCI:C5214 UMLS_CUI:C0858252 Mammary adenocarcinoma disease_ontology adenocarcinoma of breast DOID:3458 breast adenocarcinoma DOID:3459 A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. EFO:0000305 NCI:C4872 SNOMEDCT_US_2016_03_01:154513000 SNOMEDCT_US_2016_03_01:254838004 SNOMEDCT_US_2016_03_01:286898006 UMLS_CUI:C0678222 Mammary carcinoma carcinoma of breast disease_ontology DOID:3459 breast carcinoma DOID:3463 A thoracic disease that is located_in the breast. ICD10CM:N60-N65 ICD10CM:N64.9 ICD9CM:610-612.99 ICD9CM:611.9 MESH:D001941 NCI:C26709 SNOMEDCT_US_2016_03_01:155946009 SNOMEDCT_US_2016_03_01:155962003 SNOMEDCT_US_2016_03_01:155966000 SNOMEDCT_US_2016_03_01:198129001 SNOMEDCT_US_2016_03_01:198566004 SNOMEDCT_US_2016_03_01:266647006 SNOMEDCT_US_2016_03_01:79604008 UMLS_CUI:C0006145 disease_ontology DOID:3463 breast disease DOID:3480 MESH:D014603 NCI:C26908 SNOMEDCT_US_2016_03_01:95678007 UMLS_CUI:C0042161 disease_ontology DOID:3480 uveal disease DOID:3481 A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs. ICD10CM:A20.7 ICD9CM:020.2 MESH:D010930 SNOMEDCT_US_2016_03_01:9012003 UMLS_CUI:C0152936 Septicemic plague (disorder) disease_ontology DOID:3481 septicemic plague DOID:3482 A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food. ICD10CM:A20 ICD10CM:A20.9 ICD9CM:020 ICD9CM:020.9 MESH:D010930 NCI:C85015 SNOMEDCT_US_2016_03_01:186290009 SNOMEDCT_US_2016_03_01:187298009 SNOMEDCT_US_2016_03_01:58750007 UMLS_CUI:C0032064 disease_ontology DOID:3482 plague DOID:3490 ICD10CM:Q87.1 MESH:D009634 NCI:C34854 NCI:C75459 OMIM:PS163950 ORDO:648 SNOMEDCT_US_2016_03_01:205684007 SNOMEDCT_US_2016_03_01:205794007 SNOMEDCT_US_2016_03_01:205824006 SNOMEDCT_US_2016_03_01:88327006 UMLS_CUI:C0028326 Turner's phenotype, karyotype normal (disorder) disease_ontology DOID:3490 OMIM mapping confirmed by DO. [SN]. Noonan syndrome DOID:3491 DOID:5448 ICD10CM:Q96 ICD10CM:Q96.0 ICD10CM:Q96.9 MESH:D014424 NCI:C26900 NCI:C34434 NCI:C85210 SNOMEDCT_US_2016_03_01:157020008 SNOMEDCT_US_2016_03_01:205685008 SNOMEDCT_US_2016_03_01:205691005 SNOMEDCT_US_2016_03_01:254279009 SNOMEDCT_US_2016_03_01:268299006 SNOMEDCT_US_2016_03_01:268356004 SNOMEDCT_US_2016_03_01:38804009 UMLS_CUI:C0041408 UMLS_CUI:C1527168 Bonnevie-Ullrich syndrome Gonadal dysgenesis - Turner Karyotype 45, X Monosomy X XO syndrome monosomy X syndrome disease_ontology DOID:3491 No OMIM mapping, confirmed by DO. [LS]. Turner syndrome DOID:3498 A pancreatic adenocarcinoma that derives_from pancreatic duct cells. NCI:C9120 UMLS_CUI:C1335302 ductal adenocarcinoma of the pancreas disease_ontology DOID:3498 pancreatic ductal adenocarcinoma DOID:350 ICD10CM:Q82.2 MESH:D008415 NCI:C84269 OMIM:154800 SNOMEDCT_US_2016_03_01:125541005 SNOMEDCT_US_2016_03_01:397007003 SNOMEDCT_US_2016_03_01:78745000 UMLS_CUI:C0024899 mast cell hyperplasia disease_ontology DOID:350 OMIM mapping confirmed by DO. [LS]. mastocytosis DOID:3512 MESH:D018319 SNOMEDCT_US_2016_03_01:19897006 SNOMEDCT_US_2016_03_01:404037002 UMLS_CUI:C0206729 Neurosarcoma [obs] disease_ontology DOID:3512 neurofibrosarcoma DOID:3516 NCI:C7809 UMLS_CUI:C0278595 disease_ontology DOID:3516 adult fibrosarcoma DOID:3527 MESH:D002539 UMLS_CUI:C0007774 disease_ontology DOID:3527 cerebral arterial disease DOID:3529 ICD10CM:G71.2 MESH:D020512 NCI:C83010 OMIM:117000 SNOMEDCT_US_2016_03_01:43152001 UMLS_CUI:C0751951 central core disease central core disease (disorder) disease_ontology DOID:3529 OMIM mapping confirmed by DO. [SN]. central core myopathy DOID:3540 A cerebral ventricle cancer that is located_in the plexus located_in the ventricles of the brain. MESH:D016545 NCI:C3473 SNOMEDCT_US_2016_03_01:254942002 UMLS_CUI:C0085138 tumor of choroid plexus (disorder) tumor of the Choroid Plexus disease_ontology choroid plexus neoplasm DOID:3540 choroid plexus cancer DOID:3541 A cerebrum cancer that is located_in the cerebral ventricles. DOID:10856 ICD10CM:C71.5 ICD9CM:191.5 MESH:D002551 NCI:C2937 SNOMEDCT_US_2016_03_01:126958000 SNOMEDCT_US_2016_03_01:188294008 SNOMEDCT_US_2016_03_01:363471001 SNOMEDCT_US_2016_03_01:93748005 UMLS_CUI:C0007798 UMLS_CUI:C0346906 Intraventricular tumor of brain cerebral ventricle neoplasm disease_ontology DOID:3541 cerebral ventricle cancer DOID:3565 A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid "cap" cells of the arachnoid villi in the meninges. DOID:1137 DOID:3554 DOID:3567 DOID:4750 ICD10CM:D32.9 MESH:D008577 MESH:D008579 NCI:C3229 NCI:C3230 NCI:C4656 NCI:C6971 NCI:C7048 SNOMEDCT_US_2016_03_01:126965008 SNOMEDCT_US_2016_03_01:127579001 SNOMEDCT_US_2016_03_01:134307003 SNOMEDCT_US_2016_03_01:154621002 SNOMEDCT_US_2016_03_01:189940004 SNOMEDCT_US_2016_03_01:189941000 SNOMEDCT_US_2016_03_01:189945009 SNOMEDCT_US_2016_03_01:269643009 SNOMEDCT_US_2016_03_01:302820008 SNOMEDCT_US_2016_03_01:393566004 UMLS_CUI:C0025284 UMLS_CUI:C0025286 UMLS_CUI:C0349604 UMLS_CUI:C1334698 UMLS_CUI:C1336537 intracranial meningioma meningeal neoplasm meningothelial cell tumor neoplasm of the meninges primary Meningeal tumor supratentorial meningioma disease_ontology DOID:3565 meningioma DOID:3571 A gastrointestinal system cancer that is located_in the liver. DOID:12300 DOID:269 DOID:7330 DOID:915 DOID:919 ICD10CM:C22.0 ICD10CM:C22.9 ICD9CM:155.0 ICD9CM:155.2 MESH:D008113 NCI:C34803 NCI:C7692 SNOMEDCT_US_2016_03_01:126851005 SNOMEDCT_US_2016_03_01:154470007 SNOMEDCT_US_2016_03_01:187768001 SNOMEDCT_US_2016_03_01:187771009 SNOMEDCT_US_2016_03_01:187779006 SNOMEDCT_US_2016_03_01:269548006 SNOMEDCT_US_2016_03_01:363361004 SNOMEDCT_US_2016_03_01:93870000 SNOMEDCT_US_2016_03_01:95214007 UMLS_CUI:C0023903 UMLS_CUI:C0024620 UMLS_CUI:C0345904 UMLS_CUI:C0854795 Ca liver - primary (disorder) Resectable malignant neoplasm of Liver ca liver - primary hepatic cancer hepatic neoplasm malignant hepato-biliary neoplasm malignant neoplasm of liver malignant neoplasm of liver (disorder) malignant neoplasm of liver unspecified (disorder) malignant neoplasm of liver, not specified as primary or secondary malignant neoplasm of liver, primary malignant tumor of liver (disorder) neoplasm of liver (disorder) non-resectable primary hepatic malignant neoplasm primary liver cancer primary malignant neoplasm of Liver primary malignant neoplasm of liver primary malignant neoplasm of liver (disorder) primary malignant neoplasm of liver NOS (disorder) resectable malignant neoplasm of the liver disease_ontology DOID:3571 liver cancer DOID:3577 MESH:D012707 NCI:C39976 SNOMEDCT_US_2016_03_01:128857001 SNOMEDCT_US_2016_03_01:189738002 SNOMEDCT_US_2016_03_01:89089007 UMLS_CUI:C0036769 tubular androblastoma NOS (morphologic abnormality) disease_ontology DOID:3577 Sertoli cell tumor DOID:3587 A pancreatic carcinoma located_in the pancreatic duct. DOID:10023 ICD10CM:C25.3 ICD9CM:157.3 MESH:D021441 SNOMEDCT_US_2016_03_01:187793004 SNOMEDCT_US_2016_03_01:93939009 UMLS_CUI:C0153461 UMLS_CUI:C0887833 malignant neoplasm of duct of Wirsung pancreatic duct cancer disease_ontology DOID:3587 pancreatic ductal carcinoma DOID:3594 ICD10CM:C58 MESH:D002822 NCI:C2948 SNOMEDCT_US_2016_03_01:188188009 SNOMEDCT_US_2016_03_01:189444004 SNOMEDCT_US_2016_03_01:44769000 UMLS_CUI:C0008497 Chorioepithelioma disease_ontology DOID:3594 choriocarcinoma DOID:3602 A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems. MESH:D020258 NCI:C27961 SNOMEDCT_US_2016_03_01:19466003 UMLS_CUI:C0235032 neurotoxicity neurotoxicity syndrome disease_ontology DOID:3602 toxic encephalopathy DOID:3603 A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells. MESH:D018282 NCI:C3776 SNOMEDCT_US_2016_03_01:189692006 SNOMEDCT_US_2016_03_01:79143006 UMLS_CUI:C0206699 Pseudomucinous cystadenocarcinoma mucinous cystadenocarcinoma (morphologic abnormality) mucinous cystadenocarcinoma NOS (morphologic abnormality) disease_ontology DOID:3603 mucinous cystadenocarcinoma DOID:3605 NCI:C5228 SNOMEDCT_US_2016_03_01:314191009 UMLS_CUI:C1096638 cystadenocarcinoma of ovary (disorder) cystadenocarcinoma of the Ovary disease_ontology DOID:3605 ovarian cystadenocarcinoma DOID:3612 ICD10CM:H30.9 MESH:D012173 NCI:C115993 SNOMEDCT_US_2016_03_01:193450000 SNOMEDCT_US_2016_03_01:35426003 SNOMEDCT_US_2016_03_01:399463004 UMLS_CUI:C0035333 disease_ontology DOID:3612 retinitis DOID:3613 MESH:D017825 NCI:C84611 OMIM:271900 SNOMEDCT_US_2016_03_01:80544005 UMLS_CUI:C0206307 CANAVAN-VAN BOGAERT-BERTRAND DISEASE Spongy degeneration of central nervous system disease_ontology DOID:3613 OMIM mapping confirmed by DO. [SN]. Canavan disease DOID:3614 A hypogonadotropic hypogonadism with a defective sense of smell (anosmia or hyposmia). ICD10CM:E23.0 MESH:D017436 NCI:C75479 SNOMEDCT_US_2016_03_01:190559001 SNOMEDCT_US_2016_03_01:33927004 SNOMEDCT_US_2016_03_01:93559003 UMLS_CUI:C0162809 Hypogonadism with anosmia (disorder) Kallman syndrome Kallman's syndrome familial hypogonadism with anosmia disease_ontology DOID:3614 Kallmann syndrome DOID:3616 A lipoma that is a painful subcutaneous nodule, having all other features of a typical lipoma. MESH:D018206 NCI:C3733 SNOMEDCT_US_2016_03_01:189780003 SNOMEDCT_US_2016_03_01:404057003 SNOMEDCT_US_2016_03_01:73219006 UMLS_CUI:C0206632 disease_ontology DOID:3616 angiolipoma DOID:3620 A nervous system cancer that is located_in the central nervous system. DOID:0060093 DOID:1318 EFO:0000326 ICD10CM:C72.9 MESH:D016543 NCI:C4627 NCI:C9293 SNOMEDCT_US_2016_03_01:126951006 SNOMEDCT_US_2016_03_01:190135002 SNOMEDCT_US_2016_03_01:372062007 SNOMEDCT_US_2016_03_01:93744007 UMLS_CUI:C0085136 UMLS_CUI:C0348374 CNS neoplasm central nervous system tumor central nervous system tumors malignant neoplasm of central nervous system, NOS malignant tumor of CNS neoplasm of central nervous system (disorder) disease_ontology DOID:3620 central nervous system cancer DOID:3627 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size. DOID:11138 DOID:7682 DOID:7692 DOID:7703 ICD10CM:I71.1 ICD10CM:I71.3 ICD10CM:I71.5 ICD10CM:I71.8 ICD10CM:I71.9 ICD9CM:441.1 ICD9CM:441.3 ICD9CM:441.5 ICD9CM:441.6 MESH:D001014 MESH:D001019 NCI:C26697 NCI:C27046 NCI:C27198 NCI:C27299 SNOMEDCT_US_2016_03_01:14336007 SNOMEDCT_US_2016_03_01:155419006 SNOMEDCT_US_2016_03_01:155423003 SNOMEDCT_US_2016_03_01:155424009 SNOMEDCT_US_2016_03_01:195258006 SNOMEDCT_US_2016_03_01:195264004 SNOMEDCT_US_2016_03_01:195265003 SNOMEDCT_US_2016_03_01:195269009 SNOMEDCT_US_2016_03_01:195615002 SNOMEDCT_US_2016_03_01:34365005 SNOMEDCT_US_2016_03_01:67362008 SNOMEDCT_US_2016_03_01:73067008 UMLS_CUI:C0003486 UMLS_CUI:C0265010 UMLS_CUI:C0265012 UMLS_CUI:C0741160 UMLS_CUI:C1305122 Aortic aneurysm of unspecified site, ruptured Aortic aneurysm of unspecified site, ruptured (disorder) Ruptured Aortic Aneurysm Ruptured Thoracic Aneurysm Ruptured abdominal Aortic Aneurysm Ruptured abdominal aortic aneurysm (disorder) Ruptured aortic aneurysm (disorder) Ruptured aortic aneurysm NOS Ruptured aortic aneurysm NOS (disorder) Ruptured thoracic aortic aneurysm (disorder) Thoracic aortic aneurysm which has ruptured (disorder) Thoracic aortic aneurysm, ruptured Thoracoabdominal aortic aneurysm, ruptured (disorder) abdominal aortic aneurysm, ruptured ruptured abdominal aortic aneurysm ruptured aortic aneurysm ruptured thoracic aortic aneurysm ruptured thoracoabdominal aortic aneurysm disease_ontology DOID:3627 aortic aneurysm DOID:363 A female reproductive organ cancer that is located_in the uterus. DOID:4363 ICD10CM:C55 ICD9CM:179 MESH:D014594 NCI:C3435 NCI:C3552 SNOMEDCT_US_2016_03_01:126908007 SNOMEDCT_US_2016_03_01:156169001 SNOMEDCT_US_2016_03_01:188173004 SNOMEDCT_US_2016_03_01:269613007 SNOMEDCT_US_2016_03_01:371973000 SNOMEDCT_US_2016_03_01:93718007 SNOMEDCT_US_2016_03_01:94127009 UMLS_CUI:C0042138 UMLS_CUI:C0153567 CA - cancer of uterus Ca uterus NOS Tumour of uterus malignant neoplasm of uterus (disorder) malignant uterine tumor neoplasm of uterus (disorder) uterine tumor uterus neoplasm disease_ontology DOID:363 uterine cancer DOID:3635 A neuromuscular junction disease that is characterized by weakness and easy fatiguability resulting from a genetic defect at the junction where the nerve stimulates muscle activity that result in muscle weakness and may affect nerve cells (presynaptic), muscle cells (postsynaptic) or the space between nerve and muscle cells (synaptic). MESH:D020294 NCI:C84647 OMIM:PS601462 ORDO:590 SNOMEDCT_US_2016_03_01:230672006 UMLS_CUI:C0751882 familial limb-girdle myasthenia disease_ontology DOID:3635 Xref MGI. congenital myasthenic syndrome DOID:365 A urinary system disease that is located_in the bladder. ICD10CM:N32.9 ICD9CM:596.9 MESH:D001745 NCI:C2900 SNOMEDCT_US_2016_03_01:155886002 SNOMEDCT_US_2016_03_01:155890000 SNOMEDCT_US_2016_03_01:197897007 SNOMEDCT_US_2016_03_01:266630005 SNOMEDCT_US_2016_03_01:42643001 UMLS_CUI:C0005686 Urinary Bladder Disease disease_ontology DOID:365 bladder disease DOID:3650 An acquired metabolic disease that has_material_basis_in low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate. ICD10CM:E87.2 MESH:D000140 NCI:C98969 SNOMEDCT_US_2016_03_01:91273001 UMLS_CUI:C0001125 disease_ontology DOID:3650 lactic acidosis DOID:3652 A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity. ICD10CM:G31.82 MESH:D007888 NCI:C84814 OMIM:220111 OMIM:256000 ORDO:506 SNOMEDCT_US_2016_03_01:29570005 UMLS_CUI:C0023264 Infantile necrotizing encephalomyelopathy Leigh syndrome juvenile subacute necrotizing encephalomyelopathy disease_ontology subacute necrotizing encephalomyelopathy DOID:3652 Xref MGI. OMIM mapping confirmed by DO. [SN]. Leigh disease DOID:3659 A lysosomal storage disease characterized by increased sialic acid in the urine. MESH:D029461 NCI:C85067 OMIM:269921 OMIM:604369 SNOMEDCT_US_2016_03_01:238051008 UMLS_CUI:C0342853 disease_ontology DOID:3659 OMIM mapping confirmed by DO. [LS]. OMIM mapping submitted by NeuroDevNet. [LS]. sialuria DOID:366 NCI:C5121 SNOMEDCT_US_2016_03_01:126967000 UMLS_CUI:C0346319 neoplasm of olfactory nerve (disorder) tumor of Olfactory nerve disease_ontology DOID:366 olfactory nerve neoplasm DOID:3664 A hematologic cancer that has_material_basis_in mast cells. ICD10CM:D47.0 NCI:C9295 SNOMEDCT_US_2016_03_01:127581004 SNOMEDCT_US_2016_03_01:190021001 SNOMEDCT_US_2016_03_01:414653009 SNOMEDCT_US_2016_03_01:89796001 UMLS_CUI:C0334664 Mast cell Proliferative disease mast cell tumor mastocytoma disease_ontology DOID:3664 mast cell neoplasm DOID:3669 ICD10CM:I73.9 MESH:D007383 SNOMEDCT_US_2016_03_01:155430009 SNOMEDCT_US_2016_03_01:195312007 SNOMEDCT_US_2016_03_01:63491006 UMLS_CUI:C0021775 Charcot's syndrome Intermittent claudication Intermittent claudication (disorder) Intermittent claudication NOS disease_ontology DOID:3669 intermittent claudication DOID:3672 A childhood kidney neoplasm that is located_in the in the kidney as well as other locations outside the kidneys such as the liver, muscle, heart, lung, soft tissues, skin, the central nervous system. MESH:D018335 NCI:C3808 SNOMEDCT_US_2016_03_01:189812005 SNOMEDCT_US_2016_03_01:83118000 UMLS_CUI:C0206743 Rhabdoid sarcoma malignant rhabdoid tumour disease_ontology rhabdoid tumor DOID:3672 rhabdoid cancer DOID:3674 A embryonal cancer that is located in the kidney. NCI:C8715 UMLS_CUI:C0854917 renal Rhabdoid tumor disease_ontology kidney rhabdoid tumor DOID:3674 kidney rhabdoid cancer DOID:3675 NCI:C6563 UMLS_CUI:C1333003 pediatric renal tumor disease_ontology DOID:3675 childhood kidney neoplasm DOID:368 A supratentorial cancer that is located_in the cerebrum. DOID:912 ICD9CM:191.8 NCI:C4874 SNOMEDCT_US_2016_03_01:126953009 SNOMEDCT_US_2016_03_01:188300006 SNOMEDCT_US_2016_03_01:188304002 UMLS_CUI:C0153642 UMLS_CUI:C1263885 cerebral cancer neoplasm of cerebrum (disorder) tumor of Cerebrum disease_ontology DOID:368 cerebrum cancer DOID:3683 MESH:D008175 NCI:C3200 SNOMEDCT_US_2016_03_01:126713003 UMLS_CUI:C0024121 tumor of the lung disease_ontology DOID:3683 lung benign neoplasm DOID:369 MESH:D018304 NCI:C3789 NCI:C6016 SNOMEDCT_US_2016_03_01:189937004 SNOMEDCT_US_2016_03_01:189938009 SNOMEDCT_US_2016_03_01:422886007 SNOMEDCT_US_2016_03_01:68614005 SNOMEDCT_US_2016_03_01:76060004 UMLS_CUI:C0206717 Asthesioneuroblastoma (morphologic abnormality) Esthesioneuroblastoma (morphologic abnormality) Esthesioneuroepithelioma (morphologic abnormality) Esthesioneuroepithelioma [dup] (morphologic abnormality) Olfactory Esthesioneuroblastoma paranasal sinus Olfactory neuroblastoma disease_ontology DOID:369 olfactory neuroblastoma DOID:3690 ICD10CM:G54.0 MESH:D020516 NCI:C27194 SNOMEDCT_US_2016_03_01:3548001 UMLS_CUI:C0700251 Brachial plexus disorder brachial plexopathy disease_ontology DOID:3690 brachial plexus neuropathy DOID:37 An integumentary system disease that is located_in skin. DOID:1576 DOID:1698 DOID:187 DOID:6486 DOID:8948 ICD9CM:702 MESH:D012871 MESH:D012873 NCI:C27554 NCI:C3371 SNOMEDCT_US_2016_03_01:156292006 SNOMEDCT_US_2016_03_01:156396006 SNOMEDCT_US_2016_03_01:156400006 SNOMEDCT_US_2016_03_01:156445005 SNOMEDCT_US_2016_03_01:199879009 SNOMEDCT_US_2016_03_01:200580005 SNOMEDCT_US_2016_03_01:201095006 SNOMEDCT_US_2016_03_01:201107006 SNOMEDCT_US_2016_03_01:239001006 SNOMEDCT_US_2016_03_01:267806002 SNOMEDCT_US_2016_03_01:267859000 SNOMEDCT_US_2016_03_01:267860005 SNOMEDCT_US_2016_03_01:267873009 SNOMEDCT_US_2016_03_01:5613003 SNOMEDCT_US_2016_03_01:80659006 SNOMEDCT_US_2016_03_01:95320005 UMLS_CUI:C0029574 UMLS_CUI:C0037274 UMLS_CUI:C0037277 Genodermatosis skin and subcutaneous tissue disease disease_ontology DOID:37 skin disease DOID:3702 A cervix carcinoma that derives_from epithelial cells of glandular origin. NCI:C4029 SNOMEDCT_US_2016_03_01:154522004 SNOMEDCT_US_2016_03_01:254887002 SNOMEDCT_US_2016_03_01:269596006 UMLS_CUI:C0279672 adenocarcinoma cervix uteri adenocarcinoma of cervix (disorder) adenocarcinoma of the uterine Cervix disease_ontology DOID:3702 cervical adenocarcinoma DOID:3713 An ovarian carcinoma that derives_from epithelial cells of glandular origin. DOID:7816 NCI:C7700 UMLS_CUI:C0948216 Ovarian adenocarcinoma ovarian adenoacanthoma disease_ontology adenocarcinoma of the ovary DOID:3713 ovary adenocarcinoma DOID:3717 A stomach carcinoma that derives_from epithelial cells of glandular origin. NCI:C4004 SNOMEDCT_US_2016_03_01:408647009 UMLS_CUI:C0278701 adenocarcinoma of stomach (disorder) stomach adenocarcinoma disease_ontology DOID:3717 gastric adenocarcinoma DOID:3721 ICD10CM:C90.3 ICD10CM:C90.30 MESH:D010954 NCI:C6932 NCI:C9349 SNOMEDCT_US_2016_03_01:10639003 SNOMEDCT_US_2016_03_01:109987008 SNOMEDCT_US_2016_03_01:154644004 SNOMEDCT_US_2016_03_01:188719003 SNOMEDCT_US_2016_03_01:188720009 SNOMEDCT_US_2016_03_01:189507001 SNOMEDCT_US_2016_03_01:190016004 SNOMEDCT_US_2016_03_01:190017008 SNOMEDCT_US_2016_03_01:190019006 SNOMEDCT_US_2016_03_01:269652000 SNOMEDCT_US_2016_03_01:274907000 SNOMEDCT_US_2016_03_01:302852008 SNOMEDCT_US_2016_03_01:308122007 SNOMEDCT_US_2016_03_01:415112005 UMLS_CUI:C0032131 Myeloma - solitary Myeloma, solitary Solitary myeloma Solitary plasmacytoma disease_ontology DOID:3721 plasmacytoma DOID:3733 A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks. MESH:D013801 SNOMEDCT_US_2016_03_01:68771000 UMLS_CUI:C0039753 Infection by Theileria (disorder) theileriosis disease_ontology DOID:3733 theileriasis DOID:374 An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods. MESH:D009748 NCI:C26836 SNOMEDCT_US_2016_03_01:191077005 SNOMEDCT_US_2016_03_01:2492009 UMLS_CUI:C3714509 Nutritional disorder disease_ontology DOID:374 nutrition disease DOID:3742 A carcinoma of bladder that is manifested in squamous cells of the bladder. NCI:C4031 SNOMEDCT_US_2016_03_01:255111004 UMLS_CUI:C0279681 Epidermoid carcinoma of the urinary bladder squamous cell carcinoma of bladder (disorder) disease_ontology DOID:3742 bladder squamous cell carcinoma DOID:3744 A cervix carcinoma that has_material_basis_in squamous cells of the cervix. NCI:C4028 SNOMEDCT_US_2016_03_01:254886006 UMLS_CUI:C0279671 squamous cell carcinoma of cervix (disorder) squamous cell carcinoma of the Cervix Uteri disease_ontology DOID:3744 cervical squamous cell carcinoma DOID:3748 An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus. MESH:C562729 NCI:C4024 SNOMEDCT_US_2016_03_01:276804009 UMLS_CUI:C0279626 SCC of esophagus squamous cell carcinoma of esophagus (disorder) disease_ontology squamous cell carcinoma of esophagus DOID:3748 OMIM mapping confirmed by DO. [SN]. esophagus squamous cell carcinoma DOID:3763 MESH:D012734 NCI:C45909 SNOMEDCT_US_2016_03_01:237821001 SNOMEDCT_US_2016_03_01:52572004 UMLS_CUI:C0019269 disease_ontology DOID:3763 hermaphroditism DOID:3765 DOID:11226 ICD10CM:Q56 ICD10CM:Q56.3 ICD9CM:752.7 MESH:D012734 SNOMEDCT_US_2016_03_01:204895009 SNOMEDCT_US_2016_03_01:204897001 SNOMEDCT_US_2016_03_01:268229003 SNOMEDCT_US_2016_03_01:268328009 SNOMEDCT_US_2016_03_01:75164001 UMLS_CUI:C0021193 UMLS_CUI:C0033804 Indeterminate sex and pseudohermaphroditism disease_ontology DOID:3765 pseudohermaphroditism DOID:3770 MESH:D011658 NCI:C26869 SNOMEDCT_US_2016_03_01:155613001 SNOMEDCT_US_2016_03_01:196121006 SNOMEDCT_US_2016_03_01:51615001 UMLS_CUI:C0034069 Fibrosis of lung disease_ontology DOID:3770 pulmonary fibrosis DOID:3781 MESH:D000858 NCI:C34388 SNOMEDCT_US_2016_03_01:34571000 UMLS_CUI:C0003128 disease_ontology DOID:3781 anovulation DOID:3783 MESH:D038921 NCI:C84643 OMIM:303600 SNOMEDCT_US_2016_03_01:15182000 UMLS_CUI:C0265252 Coffin-Lowry syndrome (disorder) disease_ontology DOID:3783 OMIM mapping confirmed by DO. [SN]. Coffin-Lowry syndrome DOID:381 A bone inflammation disease that is located_in joint. DOID:13871 DOID:13960 DOID:1843 DOID:1903 DOID:226 DOID:2317 DOID:2318 DOID:546 DOID:9489 ICD10CM:M00-M02 ICD10CM:M12.9 ICD10CM:M19.90 ICD10CM:M25.9 ICD9CM:711 ICD9CM:716.9 ICD9CM:716.90 ICD9CM:719.9 ICD9CM:719.90 MESH:D007592 NCI:C35760 NCI:C78402 SNOMEDCT_US_2016_03_01:156508002 SNOMEDCT_US_2016_03_01:156514009 SNOMEDCT_US_2016_03_01:156616003 SNOMEDCT_US_2016_03_01:196415003 SNOMEDCT_US_2016_03_01:201455003 SNOMEDCT_US_2016_03_01:202059001 SNOMEDCT_US_2016_03_01:202061005 SNOMEDCT_US_2016_03_01:202073005 SNOMEDCT_US_2016_03_01:202634006 SNOMEDCT_US_2016_03_01:202635007 SNOMEDCT_US_2016_03_01:202645009 SNOMEDCT_US_2016_03_01:202647001 SNOMEDCT_US_2016_03_01:203721006 SNOMEDCT_US_2016_03_01:203747002 SNOMEDCT_US_2016_03_01:227588009 SNOMEDCT_US_2016_03_01:267888004 SNOMEDCT_US_2016_03_01:267904003 SNOMEDCT_US_2016_03_01:268051001 SNOMEDCT_US_2016_03_01:268056006 SNOMEDCT_US_2016_03_01:268070006 SNOMEDCT_US_2016_03_01:363162000 SNOMEDCT_US_2016_03_01:371412008 SNOMEDCT_US_2016_03_01:396233005 SNOMEDCT_US_2016_03_01:396275006 SNOMEDCT_US_2016_03_01:399269003 SNOMEDCT_US_2016_03_01:48548006 SNOMEDCT_US_2016_03_01:80843008 SNOMEDCT_US_2016_03_01:8316001 SNOMEDCT_US_2016_03_01:83486002 UMLS_CUI:C0022408 UMLS_CUI:C0157749 Ankylosis of joint of ankle and/or foot (disorder) Ankylosis of joint of forearm (disorder) Ankylosis of joint of hand (disorder) Ankylosis of joint of lower leg (disorder) Ankylosis of joint of multiple sites (disorder) Ankylosis of joint of shoulder region (disorder) Ankylosis of joint of upper arm (disorder) Ankylosis of multiple joints Infectious arthropathy Joint ankylosis of the ankle and foot Joint ankylosis of the ankle and/or foot (disorder) Joint ankylosis of the forearm Joint ankylosis of the forearm (disorder) Joint ankylosis of the hand Joint ankylosis of the lower leg Joint ankylosis of the lower leg (disorder) Joint ankylosis of the pelvic region and thigh Joint ankylosis of the pelvic region and thigh (disorder) Joint ankylosis of the shoulder region Joint ankylosis of the shoulder region (disorder) Joint ankylosis of the upper arm Joint ankylosis of the upper arm (disorder) ankylosis of ankle and foot joint ankylosis of forearm joint ankylosis of hand joint ankylosis of joint of multiple sites ankylosis of joint of pelvic region and thigh ankylosis of joint of shoulder region ankylosis of lower leg joint ankylosis of upper arm joint disease_ontology DOID:381 arthropathy DOID:3827 A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs. ICD10CM:K44 ICD10CM:K44.9 MESH:D006548 NCI:C34687 OMIM:142340 OMIM:222400 OMIM:610187 ORDO:2140 SNOMEDCT_US_2016_03_01:155748004 SNOMEDCT_US_2016_03_01:155750007 SNOMEDCT_US_2016_03_01:196901006 SNOMEDCT_US_2016_03_01:196911004 SNOMEDCT_US_2016_03_01:196912006 SNOMEDCT_US_2016_03_01:266444006 SNOMEDCT_US_2016_03_01:266511003 SNOMEDCT_US_2016_03_01:39839004 UMLS_CUI:C0019284 Diaphragmatic Hernia disease_ontology DOID:3827 Xref MGI. OMIM mapping confirmed by DO. [SN]. congenital diaphragmatic hernia DOID:3829 MESH:D010911 NCI:C3329 SNOMEDCT_US_2016_03_01:128664001 SNOMEDCT_US_2016_03_01:154621002 SNOMEDCT_US_2016_03_01:189178001 SNOMEDCT_US_2016_03_01:254956000 SNOMEDCT_US_2016_03_01:269643009 SNOMEDCT_US_2016_03_01:367095008 UMLS_CUI:C0032000 adenoma of the Pituitary gland disease_ontology DOID:3829 pituitary adenoma DOID:384 DOID:10392 ICD10CM:I45.6 ICD9CM:426.7 MESH:D014927 NCI:C35132 OMIM:194200 SNOMEDCT_US_2016_03_01:155360000 SNOMEDCT_US_2016_03_01:17869006 SNOMEDCT_US_2016_03_01:195057009 SNOMEDCT_US_2016_03_01:195061003 SNOMEDCT_US_2016_03_01:251115003 SNOMEDCT_US_2016_03_01:266304003 SNOMEDCT_US_2016_03_01:74390002 UMLS_CUI:C0043202 UMLS_CUI:C0392470 Anomalous A-V excitation Wolff-Parkinson-White pattern (finding) anomalous atrioventricular excitation disease_ontology DOID:384 OMIM mapping confirmed by DO. [LS]. OMIM mapping confirmed by DO. [SN]. Wolff-Parkinson-White syndrome DOID:3852 DOID:4133 DOID:4134 DOID:6252 DOID:6253 ICD10CM:Q85.8 MESH:D010580 NCI:C3324 NCI:C4733 NCI:C7755 OMIM:175200 SNOMEDCT_US_2016_03_01:157029009 SNOMEDCT_US_2016_03_01:277161008 SNOMEDCT_US_2016_03_01:53633000 SNOMEDCT_US_2016_03_01:54411001 UMLS_CUI:C0031269 UMLS_CUI:C0265323 UMLS_CUI:C0456487 UMLS_CUI:C1333088 Colonic hamartomatous polyp Peutz Jeghers colon polyp Peutz Jeghers polyp Peutz-Jeghers polyp of small Intestine gastric Peutz-Jeghers polyp peutz-jeghers small bowel hamartoma disease_ontology DOID:3852 OMIM mapping confirmed by DO. [SN]. Peutz-Jeghers syndrome DOID:3855 NCI:C39908 SNOMEDCT_US_2016_03_01:236740006 UMLS_CUI:C0341767 Seminal Vesicle neoplasm tumor of seminal vesicle (disorder) disease_ontology DOID:3855 seminal vesicle tumor DOID:3856 A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum. DOID:10284 ICD10CM:C60-C63 ICD10CM:C63.9 ICD9CM:187.9 MESH:D005834 NCI:C3054 NCI:C8561 SNOMEDCT_US_2016_03_01:126895004 SNOMEDCT_US_2016_03_01:190127000 SNOMEDCT_US_2016_03_01:190130007 SNOMEDCT_US_2016_03_01:363515000 SNOMEDCT_US_2016_03_01:93885006 UMLS_CUI:C0017417 UMLS_CUI:C0153606 male genital cancer male reproductive system neoplasm malignant neoplasm of male genital organ or tract malignant neoplasm of male genital organ, NOS malignant neoplasm of male genital organ, site unspecified malignant neoplasm of male genital organ, unspecified (disorder) malignant neoplasm of male genital organs (disorder) malignant tumor of male Reproductive system malignant tumor of male genital organ malignant tumor of male genital organ (disorder) neoplasm of male genital organ tumor of male Reproductive system disease_ontology male genital neoplasm DOID:3856 male reproductive organ cancer DOID:3869 MESH:D008527 NCI:C3997 UMLS_CUI:C0278510 pediatric Medulloblastoma disease_ontology DOID:3869 childhood medulloblastoma DOID:3876 MESH:D003112 SNOMEDCT_US_2016_03_01:35065006 UMLS_CUI:C0009377 primary chronic pseudo-obstruction of colon (disorder) disease_ontology DOID:3876 colonic pseudo-obstruction DOID:3877 MESH:D003109 UMLS_CUI:C0009374 disease_ontology DOID:3877 functional colonic disease DOID:3878 MESH:D007418 NCI:C34733 SNOMEDCT_US_2016_03_01:235825006 UMLS_CUI:C0021847 Pseudo-obstruction of intestine (disorder) intestinal Pseudo-obstruction intestine pseudoobstruction disease_ontology DOID:3878 intestinal pseudo-obstruction DOID:3883 An autosomal dominant disease that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers. DOID:0050586 DOID:3040 MESH:D003123 NCI:C120083 NCI:C8494 OMIM:120435 OMIM:609310 OMIM:613244 OMIM:614331 OMIM:614337 OMIM:614350 OMIM:614385 ORDO:144 SNOMEDCT_US_2016_03_01:315058005 UMLS_CUI:C0009405 UMLS_CUI:C1333990 COCA 1 HNPCC - hereditary nonpolyposis colon cancer Hereditary Defective Mismatch Repair syndrome hereditary non-polyposis colon cancer type 1 hereditary nonpolyposis colorectal cancer hereditary nonpolyposis colorectal neoplasm disease_ontology DOID:3883 OMIM mapping confirmed by DO. [SN]. Lynch syndrome DOID:3891 A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy. MESH:D010927 SNOMEDCT_US_2016_03_01:156185006 SNOMEDCT_US_2016_03_01:199610002 SNOMEDCT_US_2016_03_01:237292005 SNOMEDCT_US_2016_03_01:267337006 UMLS_CUI:C0032051 disease_ontology DOID:3891 placental insufficiency DOID:3892 An adenoma that is located_in the pancreas and is characterized by overproduction of insulin. DOID:3903 MESH:D007340 MESH:D007516 NCI:C3140 NCI:C65184 NCI:C95598 SNOMEDCT_US_2016_03_01:134154009 SNOMEDCT_US_2016_03_01:189586007 SNOMEDCT_US_2016_03_01:25324008 SNOMEDCT_US_2016_03_01:302822000 SNOMEDCT_US_2016_03_01:76345009 UMLS_CUI:C0021670 UMLS_CUI:C0022134 Insulin-Producing tumor of Islet cells Islet cell adenoma disease_ontology DOID:3892 insulinoma DOID:3904 A bronchus cancer that has_material_basis_in epithelial cells. CSP:2017-6052 MESH:D002283 NCI:C35875 SNOMEDCT_US_2016_03_01:154485001 SNOMEDCT_US_2016_03_01:254622008 SNOMEDCT_US_2016_03_01:269561006 SNOMEDCT_US_2016_03_01:363493006 UMLS_CUI:C0007121 BC - Bronchogenic carcinoma disease_ontology DOID:3904 bronchus carcinoma DOID:3905 A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis. EFO:0001071 ICD10CM:C34.90 NCI:C4878 SNOMEDCT_US_2016_03_01:154485001 SNOMEDCT_US_2016_03_01:187875007 SNOMEDCT_US_2016_03_01:269561006 UMLS_CUI:C0684249 cancer of lung disease_ontology carcinoma of lung DOID:3905 OMIM mapping confirmed by DO. [SN]. lung carcinoma DOID:3907 A non-small cell lung carcinoma that has_material_basis_in the squamous cell. NCI:C3493 SNOMEDCT_US_2016_03_01:254634000 UMLS_CUI:C0149782 Epidermoid cell carcinoma of the lung disease_ontology squamous cell carcinoma of lung DOID:3907 lung squamous cell carcinoma DOID:3908 A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma. EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 SNOMEDCT_US_2016_03_01:254637007 UMLS_CUI:C0007131 NSCLC Non-small cell lung cancer (disorder) disease_ontology DOID:3908 non-small cell lung carcinoma DOID:3910 A non-small cell lung carcinoma that derives_from epithelial cells of glandular origin. DOID:4826 EFO:0000571 MESH:C538231 NCI:C27745 NCI:C3512 SNOMEDCT_US_2016_03_01:254626006 UMLS_CUI:C0152013 UMLS_CUI:C1335060 nonsmall cell adenocarcinoma disease_ontology adenocarcinoma of lung DOID:3910 lung adenocarcinoma DOID:3939 NCI:C4501 SNOMEDCT_US_2016_03_01:254828009 UMLS_CUI:C0346117 malignant lipomatous tumor (disorder) malignant tumor of Adipose tissue disease_ontology DOID:3939 lipomatous cancer DOID:3947 MESH:D000308 NCI:C113208 SNOMEDCT_US_2016_03_01:111561007 SNOMEDCT_US_2016_03_01:190520005 SNOMEDCT_US_2016_03_01:275437005 SNOMEDCT_US_2016_03_01:47270006 UMLS_CUI:C0001622 Adrenocortical hyperfunction hyperadrenalism hypercortisolism disease_ontology DOID:3947 adrenal gland hyperfunction DOID:3948 An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. MESH:D018268 NCI:C9325 OMIM:202300 SNOMEDCT_US_2016_03_01:2227007 SNOMEDCT_US_2016_03_01:255035007 UMLS_CUI:C0206686 Adrenal cortical carcinoma (morphologic abnormality) carcinoma of the Adrenal cortex disease_ontology DOID:3948 adrenocortical carcinoma DOID:3950 An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. SNOMEDCT_US_2015_03_01:255035007 UMLS_CUI:C1370740 carcinoma of the Adrenal gland disease_ontology DOID:3950 adrenal carcinoma DOID:3952 MESH:D000303 SNOMEDCT_US_2016_03_01:129636003 UMLS_CUI:C0001614 disease_ontology DOID:3952 adrenal cortex disease DOID:3953 An endocrine gland cancer located_in the adrenal glands which are located above the kidneys. DOID:11007 ICD10CM:C74 ICD10CM:C74.9 ICD9CM:194.0 MESH:D000310 NCI:C2859 NCI:C9338 SNOMEDCT_US_2016_03_01:127021009 SNOMEDCT_US_2016_03_01:188337000 SNOMEDCT_US_2016_03_01:188338005 SNOMEDCT_US_2016_03_01:363355002 SNOMEDCT_US_2016_03_01:93665005 UMLS_CUI:C0001624 UMLS_CUI:C0750887 adrenal cancer adrenal neoplasm malignant Adrenal tumor malignant neoplasm of adrenal gland neoplasm of adrenal gland (disorder) tumor of the Adrenal gland disease_ontology DOID:3953 adrenal gland cancer DOID:3959 An adrenalcortical carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin. Adrenal cortex adenocarcinoma Adrenal cortical adenocarcinoma disease_ontology DOID:3959 adrenal cortical adenocarcinoma DOID:396 A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils. ICD10CM:I42.3 NCI:C27044 SNOMEDCT_US_2016_03_01:33258008 UMLS_CUI:C0264834 Eosinophilic Endomyocardial disease disease_ontology DOID:396 Loeffler endocarditis DOID:3962 A thyroid carcinoma that has_material_basis_in follicular cells. MESH:D018263 NCI:C8054 OMIM:188470 SNOMEDCT_US_2016_03_01:189642005 SNOMEDCT_US_2016_03_01:255028004 SNOMEDCT_US_2016_03_01:28173006 SNOMEDCT_US_2016_03_01:5257006 UMLS_CUI:C0206682 Follicular adenocarcinoma (morphologic abnormality) Follicular adenocarcinoma, well differentiated (morphologic abnormality) Follicular carcinoma Follicular carcinoma of the Thyroid gland Follicular thyroid carcinoma (disorder) Thyroid adenocarcinoma disease_ontology DOID:3962 OMIM mapping confirmed by DO. [SN]. follicular thyroid carcinoma DOID:3963 A thyroid cancer that has_material_basis_in epithelial cells. EFO:0002892 MESH:D013964 NCI:C4815 UMLS_CUI:C0549473 head and neck cancer, Thyroid disease_ontology DOID:3963 thyroid carcinoma DOID:3969 A thyroid carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer. MESH:C536915 NCI:C4035 OMIM:188550 SNOMEDCT_US_2016_03_01:255029007 SNOMEDCT_US_2016_03_01:4797003 UMLS_CUI:C0238463 Papillary carcinoma of the Thyroid gland disease_ontology DOID:3969 OMIM mapping confirmed by DO. [SN]. papillary thyroid carcinoma DOID:397 ICD10CM:I42.5 MESH:D002313 NCI:C62798 OMIM:115210 OMIM:609578 OMIM:612422 OMIM:615248 ORDO:75249 SNOMEDCT_US_2016_03_01:389996009 SNOMEDCT_US_2016_03_01:415295002 SNOMEDCT_US_2016_03_01:90828009 UMLS_CUI:C0007196 Cardiomyopathy, constrictive Restrictive cardiomyopathy Restrictive cardiomyopathy (disorder) primary restrictive cardiomyopathy (disorder) disease_ontology Familial restrictive cardiomyopathy DOID:397 Xref MGI. OMIM mappings 115210, 612422 added from NeuroDevNet [WAK]. restrictive cardiomyopathy DOID:3973 A follicular thyroid carcinoma that has_material_basis_in parafollicular cells. MESH:C536914 NCI:C3879 SNOMEDCT_US_2016_03_01:128916007 SNOMEDCT_US_2016_03_01:255032005 SNOMEDCT_US_2016_03_01:32913002 UMLS_CUI:C0238462 Medullary carcinoma of the Thyroid gland Medullary thyroid carcinoma (disorder) Ultimobranchial thyroid tumor Ultimobranchial thyroid tumour medullary thyroid carcinoma disease_ontology DOID:3973 thyroid medullary carcinoma DOID:3978 A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium. ICD9CM:425.8 SNOMEDCT_US_2016_03_01:195580005 UMLS_CUI:C0155699 disease_ontology DOID:3978 extrinsic cardiomyopathy DOID:3981 A neurodegeneration with brain iron accumulation that has_material_basis_in autosomal recessive inheritance of mutation in the PANK2 gene on chromosome 20p13. ICD10CM:G23.0 MESH:D006211 NCI:C84988 NCI:C8967 OMIM:234200 SNOMEDCT_US_2016_03_01:2992000 UMLS_CUI:C0018523 Hallervorden-Spatz disease Hallervorden-Spatz syndrome NBIA1 Pigmentary pallidal degeneration (disorder) brain Iron Accumulation type I syndrome neurodegeneration with brain iron accumulation 1 disease_ontology DOID:3981 OMIM mapping confirmed by DO. [SN]. pantothenate kinase-associated neurodegeneration DOID:399 A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes. DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 MESH:D014376 SNOMEDCT_US_2016_03_01:15202009 UMLS_CUI:C0041295 disease_ontology DOID:399 tuberculosis DOID:3996 An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra. ICD10CM:C68.9 ICD9CM:189.9 SNOMEDCT_US_2016_03_01:190132004 SNOMEDCT_US_2016_03_01:448233000 UMLS_CUI:C0348371 disease_ontology DOID:3996 urinary system cancer DOID:4 A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. MESH:D004194 NCI:C2991 SNOMEDCT_US_2016_03_01:64572001 UMLS_CUI:C0012634 disease_ontology DOID:4 disease DOID:4001 EFO:0001075 MESH:C538090 NCI:C4908 UMLS_CUI:C0677886 Ovarian carcinoma disease_ontology DOID:4001 OMIM mapping confirmed by DO. [SN]. ovarian carcinoma DOID:4006 A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder. NCI:C39851 SNOMEDCT_US_2016_03_01:255109008 SNOMEDCT_US_2016_03_01:393562002 UMLS_CUI:C0279680 bladder transitional cell carcinoma transitional cell carcinoma of bladder urinary bladder urothelial carcinoma urothelial bladder carcinoma disease_ontology DOID:4006 bladder urothelial carcinoma DOID:4007 A urinary bladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. EFO:0000292 NCI:C4912 SNOMEDCT_US_2016_03_01:154540000 SNOMEDCT_US_2016_03_01:255108000 SNOMEDCT_US_2016_03_01:269607003 UMLS_CUI:C0699885 carcinoma OF BLADDER carcinoma bladder carcinoma of bladder (disorder) carcinoma of urinary bladder disease_ontology carcinoma of bladder DOID:4007 bladder carcinoma DOID:4022 MESH:D014518 NCI:C123159 OMIM:191650 SNOMEDCT_US_2016_03_01:12818004 UMLS_CUI:C0041960 disease_ontology DOID:4022 OMIM mapping confirmed by DO. [LS]. ureterocele DOID:4029 A stomach disease that is an inflammation of the lining of the stomach. DOID:4032 DOID:8697 DOID:8845 DOID:9190 ICD10CM:K29.7 MESH:D005756 NCI:C26780 SNOMEDCT_US_2016_03_01:155711008 SNOMEDCT_US_2016_03_01:196743006 SNOMEDCT_US_2016_03_01:235653009 SNOMEDCT_US_2016_03_01:266503008 SNOMEDCT_US_2016_03_01:4556007 UMLS_CUI:C0017152 Erosive Gastritis Erosive gastropathy acute gastric mucosal erosion disease_ontology DOID:4029 gastritis DOID:403 A gastrointestinal system disease that is located_in the mouth. MESH:D009059 NCI:C27641 NCI:C3240 SNOMEDCT_US_2016_03_01:118938008 SNOMEDCT_US_2016_03_01:155630004 SNOMEDCT_US_2016_03_01:266484002 UMLS_CUI:C0026636 disease_ontology DOID:403 mouth disease DOID:4037 NCI:C27329 UMLS_CUI:C0877152 disease_ontology DOID:4037 necrotizing gastritis DOID:404 An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting. DOID:9802 MESH:D014385 SNOMEDCT_US_2016_03_01:154286002 SNOMEDCT_US_2016_03_01:186228005 SNOMEDCT_US_2016_03_01:240376003 UMLS_CUI:C0041312 Tuberculosis of gastrointestinal tract Tuberculosis of gastrointestinal tract (disorder) Tuberculosis of gastrointestinal tract NOS (disorder) Tuberculosis of intestines, peritoneum and mesenteric glands (disorder) Tuberculosis of intestines, peritoneum, and mesenteric glands tuberculosis of intestines, peritoneum and mesenteric glands disease_ontology DOID:404 gastrointestinal tuberculosis DOID:4043 NCI:C6516 UMLS_CUI:C1334619 malignant tumor of Skeletal Muscle disease_ontology DOID:4043 skeletal muscle cancer DOID:4045 A musculoskeletal system cancer that is located_in muscle. DOID:4046 ICD10CM:C49 MESH:D009217 MESH:D019042 NCI:C4883 SNOMEDCT_US_2016_03_01:20667008 SNOMEDCT_US_2016_03_01:363495004 SNOMEDCT_US_2016_03_01:93913006 UMLS_CUI:C0027095 UMLS_CUI:C0684743 Myosarcoma (morphologic abnormality) malignant neoplasm of muscle, NOS malignant tumor of muscle (disorder) malignant tumor of the Muscle myosarcoma disease_ontology DOID:4045 muscle cancer DOID:4051 DOID:4382 MESH:D018232 NCI:C3749 NCI:C7958 OMIM:268220 SNOMEDCT_US_2016_03_01:404053004 SNOMEDCT_US_2016_03_01:63449009 UMLS_CUI:C0206655 UMLS_CUI:C0279613 Alveolar Rhabdomyosarcoma Alveolar rhabdomyosarcoma (disorder) Alveolar rhabdomyosarcoma (morphologic abnormality) alveolar childhood rhabdomyosarcoma pediatric Alveolar Rhabdomyosarcoma disease_ontology DOID:4051 OMIM mapping confirmed by DO. [SN]. alveolar rhabdomyosarcoma DOID:4074 A pancreatic carcinoma that derives_from epithelial cells of glandular origin. NCI:C8294 SNOMEDCT_US_2016_03_01:700423003 UMLS_CUI:C0281361 pancreas adenocarcinoma disease_ontology adenocarcinoma of the pancreas DOID:4074 pancreatic adenocarcinoma DOID:4079 A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). DOID:989 MESH:D006349 MESH:D016127 NCI:C45525 SNOMEDCT_US_2016_03_01:195013005 SNOMEDCT_US_2016_03_01:368009 SNOMEDCT_US_2016_03_01:398995000 UMLS_CUI:C0018824 UMLS_CUI:C0079485 Valvular heart disease disease_ontology DOID:4079 heart valve disease DOID:4080 A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal. MESH:D014262 NCI:C50842 NCI:C50843 SNOMEDCT_US_2016_03_01:111287006 SNOMEDCT_US_2016_03_01:155347006 SNOMEDCT_US_2016_03_01:251009000 SNOMEDCT_US_2016_03_01:266298007 UMLS_CUI:C0040961 Tricuspid incompetence Tricuspid regurgitation Tricuspid valve regurgitation (disorder) disease_ontology DOID:4080 tricuspid valve insufficiency DOID:409 DOID:2164 DOID:2165 DOID:46 ICD10CM:K70-K77 ICD10CM:K76.9 ICD9CM:573.9 MESH:D008107 NCI:C3196 SNOMEDCT_US_2016_03_01:155807008 SNOMEDCT_US_2016_03_01:155817003 SNOMEDCT_US_2016_03_01:155822003 SNOMEDCT_US_2016_03_01:197375001 SNOMEDCT_US_2016_03_01:197551000 SNOMEDCT_US_2016_03_01:235856003 SNOMEDCT_US_2016_03_01:266535008 SNOMEDCT_US_2016_03_01:62857009 UMLS_CUI:C0023895 disorder of liver (disorder) hepatic disorder disease_ontology DOID:409 liver disease DOID:4090 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss. DOID:4019 ICD10CM:R48.1 ICD10CM:R48.2 MESH:D000377 MESH:D001072 NCI:C84542 SNOMEDCT_US_2016_03_01:158320000 SNOMEDCT_US_2016_03_01:158322008 SNOMEDCT_US_2016_03_01:192146008 SNOMEDCT_US_2016_03_01:206989009 SNOMEDCT_US_2016_03_01:206991001 SNOMEDCT_US_2016_03_01:250058008 SNOMEDCT_US_2016_03_01:271724003 SNOMEDCT_US_2016_03_01:42341009 SNOMEDCT_US_2016_03_01:68345001 SNOMEDCT_US_2016_03_01:6950007 UMLS_CUI:C0001816 UMLS_CUI:C0003635 Dyspraxia (finding) Dyspraxia syndrome disease_ontology DOID:4090 agnosia DOID:4109 A parasitic ectoparasitic infectious disease that involves parasitic infestation of blood feeding ticks of the families Ixodidae and Argasidae on animals and humans. Ticks are vectors of a number diseases, including Lyme disease, Q fever, Colorado tick fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis and tick-borne meningoencephalitis, as well as anaplasmosis in cattle and canine jaundice. MESH:D013984 UMLS_CUI:C0040196 disease_ontology DOID:4109 tick infestation DOID:4110 A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host. MESH:D004478 UMLS_CUI:C0013578 ectoparasitism disease_ontology DOID:4110 parasitic ectoparasitic infectious disease DOID:4123 An integumentary system disease that is located_in nail. ICD10CM:L60 ICD10CM:L60.9 ICD9CM:703 ICD9CM:703.9 MESH:D009260 SNOMEDCT_US_2016_03_01:156401005 SNOMEDCT_US_2016_03_01:17790008 SNOMEDCT_US_2016_03_01:201127007 SNOMEDCT_US_2016_03_01:267861009 UMLS_CUI:C0027339 disease_ontology DOID:4123 nail disease DOID:4138 MESH:D001649 NCI:C96716 SNOMEDCT_US_2016_03_01:118926004 SNOMEDCT_US_2016_03_01:197455006 UMLS_CUI:C0005395 bile duct disorder NOS (disorder) disorder of bile duct (disorder) disease_ontology DOID:4138 bile duct disease DOID:4143 A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis. DOID:9984 ICD10CM:C69.6 ICD9CM:190.1 MESH:D009918 NCI:C3290 NCI:C3562 SNOMEDCT_US_2016_03_01:127003006 SNOMEDCT_US_2016_03_01:188270008 SNOMEDCT_US_2016_03_01:363462005 SNOMEDCT_US_2016_03_01:93932000 UMLS_CUI:C0029185 UMLS_CUI:C0153626 malignant neoplasm of orbit neoplasm of orbit proper (disorder) orbit cancer orbital tumor disease_ontology DOID:4143 orbital cancer DOID:4154 ICD10CM:K00.5 MESH:D003811 NCI:C84667 OMIM:125490 OMIM:125500 SNOMEDCT_US_2016_03_01:196286005 SNOMEDCT_US_2016_03_01:367461002 SNOMEDCT_US_2016_03_01:45742009 UMLS_CUI:C0011436 disease_ontology DOID:4154 OMIM mapping confirmed by DO. [SN]. dentinogenesis imperfecta DOID:4159 An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells. MESH:D012878 NCI:C2920 SNOMEDCT_US_2016_03_01:188143008 SNOMEDCT_US_2016_03_01:190107001 SNOMEDCT_US_2016_03_01:363511009 SNOMEDCT_US_2016_03_01:372130007 SNOMEDCT_US_2016_03_01:94047004 UMLS_CUI:C0007114 CA - skin cancer malignant neoplasm of skin melanoma and Non-melanoma skin cancer disease_ontology cancer of skin DOID:4159 skin cancer DOID:4160 NCI:C42048 UMLS_CUI:C1511934 disease_ontology DOID:4160 differentiating neuroblastoma DOID:4166 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years. DOID:11095 ICD10CM:A51.0 MESH:D002601 SNOMEDCT_US_2016_03_01:266127002 SNOMEDCT_US_2016_03_01:58433006 UMLS_CUI:C0007939 syphilitic chancre disease_ontology DOID:4166 syphilis DOID:417 An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues. ICD9CM:720 OMIM:109100 UMLS_CUI:C0003089 autoimmune disease disease_ontology DOID:417 Xref MGI. hypersensitivity reaction type II disease DOID:418 A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies. EFO:0000717 ICD10CM:M34.0 ICD10CM:M34.9 ICD9CM:710.1 MESH:D012595 NCI:C72070 SNOMEDCT_US_2016_03_01:128457007 SNOMEDCT_US_2016_03_01:156451000 SNOMEDCT_US_2016_03_01:201440007 SNOMEDCT_US_2016_03_01:268049000 SNOMEDCT_US_2016_03_01:89155008 UMLS_CUI:C0036421 PSS (progressive systemic sclerosis) Scleroderma Scleroderma (& [systemic sclerosis]) Scleroderma syndrome progressive systemic sclerosis systemic sclerosis disease_ontology DOID:418 systemic scleroderma DOID:4183 MESH:D011556 OMIM:612463 SNOMEDCT_US_2016_03_01:190867002 SNOMEDCT_US_2016_03_01:237659007 SNOMEDCT_US_2016_03_01:8084001 UMLS_CUI:C0033835 Normocalcemic pseudohypoparathyroidism (disorder) [Ambiguous] Pseudopseudohypoparathyroidism (disorder) disease_ontology DOID:4183 OMIM mapping confirmed by DO. [SN]. pseudopseudohypoparathyroidism DOID:4184 ICD10CM:E20.1 MESH:D011547 NCI:C99027 OMIM:603233 OMIM:612462 SNOMEDCT_US_2016_03_01:154697005 SNOMEDCT_US_2016_03_01:190867002 SNOMEDCT_US_2016_03_01:267479004 SNOMEDCT_US_2016_03_01:58976002 UMLS_CUI:C0033806 disease_ontology DOID:4184 OMIM mapping confirmed by DO. [SN]. pseudohypoparathyroidism DOID:4186 A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand. MESH:D001184 SNOMEDCT_US_2016_03_01:386701004 SNOMEDCT_US_2016_03_01:8187005 UMLS_CUI:C0003910 Articulation impairment Phonological disorder disease_ontology DOID:4186 articulation disorder DOID:419 A rheumatic disease and collagen disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs. MESH:D012594 NCI:C26746 SNOMEDCT_US_2016_03_01:128457007 SNOMEDCT_US_2016_03_01:156451000 SNOMEDCT_US_2016_03_01:156454008 SNOMEDCT_US_2016_03_01:201440007 SNOMEDCT_US_2016_03_01:201441006 SNOMEDCT_US_2016_03_01:267874003 SNOMEDCT_US_2016_03_01:268049000 SNOMEDCT_US_2016_03_01:287005009 SNOMEDCT_US_2016_03_01:89155008 UMLS_CUI:C0011644 dermatosclerosis disease_ontology DOID:419 scleroderma DOID:4194 MESH:D044882 NCI:C53655 SNOMEDCT_US_2016_03_01:126877002 UMLS_CUI:C1257958 disorder of glucose metabolism (disorder) disease_ontology DOID:4194 glucose metabolism disease DOID:4195 ICD10CM:R73.9 MESH:D006943 NCI:C26797 SNOMEDCT_US_2016_03_01:144187006 SNOMEDCT_US_2016_03_01:154719004 SNOMEDCT_US_2016_03_01:207289007 SNOMEDCT_US_2016_03_01:207643008 SNOMEDCT_US_2016_03_01:237598005 SNOMEDCT_US_2016_03_01:270004003 SNOMEDCT_US_2016_03_01:315299009 SNOMEDCT_US_2016_03_01:390730002 SNOMEDCT_US_2016_03_01:80394007 UMLS_CUI:C0020456 disease_ontology DOID:4195 hyperglycemia DOID:420 ICD10CM:L68 ICD10CM:L68.3 ICD10CM:L68.9 MESH:D006983 NCI:C79597 SNOMEDCT_US_2016_03_01:156409007 SNOMEDCT_US_2016_03_01:201164001 SNOMEDCT_US_2016_03_01:201165000 SNOMEDCT_US_2016_03_01:271607001 SNOMEDCT_US_2016_03_01:29966009 SNOMEDCT_US_2016_03_01:40090008 UMLS_CUI:C0020555 disease_ontology DOID:420 hypertrichosis DOID:421 An integumentary system disease that is located_in hair. MESH:D006201 NCI:C34656 SNOMEDCT_US_2016_03_01:156407009 SNOMEDCT_US_2016_03_01:267862002 SNOMEDCT_US_2016_03_01:279425004 UMLS_CUI:C0018500 disease_ontology DOID:421 hair disease DOID:422 MESH:D020914 NCI:C84648 UMLS_CUI:C0752282 disease_ontology DOID:422 congenital structural myopathy DOID:4223 Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus. ICD10CM:L08.0 ICD9CM:686.0 ICD9CM:686.00 MESH:D011711 SNOMEDCT_US_2016_03_01:156323008 SNOMEDCT_US_2016_03_01:200719000 SNOMEDCT_US_2016_03_01:267838007 SNOMEDCT_US_2016_03_01:70759006 UMLS_CUI:C0034212 disease_ontology DOID:4223 pyoderma DOID:4226 MESH:D018203 NCI:C8973 SNOMEDCT_US_2016_03_01:699356008 SNOMEDCT_US_2016_03_01:70555003 UMLS_CUI:C0206630 ESS Undifferentiated endometrial sarcoma endometrial stromal sarcoma, high grade disease_ontology DOID:4226 endometrial stromal sarcoma DOID:423 A muscular disease in which the muscle fibers do not function resulting in muscular weakness. ICD10CM:G72.9 ICD10CM:M60-M63 ICD10CM:M62.9 ICD9CM:359.9 MESH:D009135 NCI:C101216 SNOMEDCT_US_2016_03_01:129565002 SNOMEDCT_US_2016_03_01:155094005 SNOMEDCT_US_2016_03_01:155099000 SNOMEDCT_US_2016_03_01:203833006 SNOMEDCT_US_2016_03_01:203845002 SNOMEDCT_US_2016_03_01:267711006 SNOMEDCT_US_2016_03_01:267714003 SNOMEDCT_US_2016_03_01:268103006 SNOMEDCT_US_2016_03_01:52794005 SNOMEDCT_US_2016_03_01:75047002 UMLS_CUI:C0026848 disease_ontology DOID:423 myopathy DOID:4230 NCI:C6511 UMLS_CUI:C1334620 malignant tumor of Smooth Muscle disease_ontology DOID:4230 smooth muscle cancer DOID:4231 MESH:D051642 NCI:C35765 SNOMEDCT_US_2016_03_01:128741006 SNOMEDCT_US_2016_03_01:154614002 SNOMEDCT_US_2016_03_01:189773000 SNOMEDCT_US_2016_03_01:302843004 SNOMEDCT_US_2016_03_01:72079004 UMLS_CUI:C1509147 disease_ontology DOID:4231 histiocytoma DOID:4236 A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components. DOID:1971 DOID:2610 DOID:4234 MESH:D002296 MESH:D018199 MESH:D018200 NCI:C34448 NCI:C3730 NCI:C8975 SNOMEDCT_US_2016_03_01:112684005 SNOMEDCT_US_2016_03_01:189808004 SNOMEDCT_US_2016_03_01:63264007 SNOMEDCT_US_2016_03_01:84427001 UMLS_CUI:C0007140 UMLS_CUI:C0206627 UMLS_CUI:C1334603 MMMT Mesodermal mixed tumor (morphologic abnormality) malignant mixed Mullerian tumor malignant mixed mesodermal (mullerian) tumor mesodermal mixed tumor mixed Mesodermal (mullerian) tumor mullerian mixed tumor mullerian mixed tumor (morphologic abnormality) disease_ontology DOID:4236 carcinosarcoma DOID:424 ICD10CM:P28.0 ICD9CM:770.4 SNOMEDCT_US_2016_03_01:123275009 SNOMEDCT_US_2016_03_01:42908004 UMLS_CUI:C0270163 primary atelectasis of newborn primary atelectasis, in perinatal period disease_ontology DOID:424 pulmonary immaturity DOID:4250 ICD10CM:H11.82 ICD9CM:372.81 SNOMEDCT_US_2016_03_01:408663001 UMLS_CUI:C0878693 disease_ontology DOID:4250 conjunctivochalasis DOID:4251 ICD10CM:H10-H11 ICD10CM:H11.9 ICD9CM:372 ICD9CM:372.9 MESH:D003229 NCI:C27605 SNOMEDCT_US_2016_03_01:155161009 SNOMEDCT_US_2016_03_01:155169006 SNOMEDCT_US_2016_03_01:193906005 SNOMEDCT_US_2016_03_01:194583004 SNOMEDCT_US_2016_03_01:267735001 SNOMEDCT_US_2016_03_01:59698003 UMLS_CUI:C0009759 disease_ontology DOID:4251 conjunctival disease DOID:4252 A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes. MESH:D038261 NCI:C84545 OMIM:203450 SNOMEDCT_US_2016_03_01:81854007 UMLS_CUI:C0270726 Alexander's disease disease_ontology DOID:4252 OMIM mapping confirmed by DO. [SN]. Alexander disease DOID:4254 A bone remodeling disease that results_in abnormal elevated bone density or mass. ICD10CM:Q78.2 MESH:D010026 NCI:C41236 SNOMEDCT_US_2016_03_01:49347007 UMLS_CUI:C0029464 disease_ontology DOID:4254 osteosclerosis DOID:4280 DOID:4296 NCI:C62282 SNOMEDCT_US_2016_03_01:128636006 SNOMEDCT_US_2016_03_01:403910009 UMLS_CUI:C1304300 Basal cell carcinoma, nodular (morphologic abnormality) Circumscribed solid basal cell carcinoma skin nodulo-ulcerative basal cell carcinoma skin solid (nodular) Basal cell carcinoma disease_ontology DOID:4280 nodular basal cell carcinoma DOID:4305 A giant cell tumor and bone cancer and bone tissue neoplasm that results_in the presence of multinucleated giant cells (osteoclast-like cell). MESH:D018212 NCI:C121932 SNOMEDCT_US_2016_03_01:189891002 SNOMEDCT_US_2016_03_01:57500000 SNOMEDCT_US_2016_03_01:697970009 UMLS_CUI:C0206638 Giant cell neoplasm of bone Giant cell tumor of bone (morphologic abnormality) Giant cell tumor of bone NOS (morphologic abnormality) disease_ontology giant cell myeloma osteoclastoma DOID:4305 bone giant cell tumor DOID:4306 ICD10CM:M54.1 ICD10CM:M54.10 MESH:D011843 SNOMEDCT_US_2016_03_01:394640000 SNOMEDCT_US_2016_03_01:72274001 UMLS_CUI:C0700594 nerve root disorder nerve root disorder, NOS disease_ontology DOID:4306 radiculopathy DOID:4307 MESH:D011128 NCI:C34934 SNOMEDCT_US_2016_03_01:75572007 UMLS_CUI:C0032586 Polyradiculopathy (disorder) disease_ontology DOID:4307 polyradiculopathy DOID:4308 MESH:D011129 SNOMEDCT_US_2016_03_01:128078004 UMLS_CUI:C0032587 Polyradiculoneuropathy (disorder) disease_ontology DOID:4308 polyradiculoneuropathy DOID:4310 MESH:D018235 NCI:C3751 SNOMEDCT_US_2016_03_01:189799007 SNOMEDCT_US_2016_03_01:75109009 UMLS_CUI:C0206658 Smooth muscle tumor NOS (morphologic abnormality) Smooth muscle tumour of uncertain malignant potential neoplasm of the Smooth Muscle disease_ontology DOID:4310 smooth muscle tumor DOID:4325 A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding. ICD10CM:A98.4 MESH:D019142 NCI:C36171 SNOMEDCT_US_2016_03_01:123323003 SNOMEDCT_US_2016_03_01:186746000 SNOMEDCT_US_2016_03_01:37109004 UMLS_CUI:C0282687 Ebola virus disease disease_ontology DOID:4325 Ebola hemorrhagic fever DOID:4329 MESH:D031249 NCI:C53972 SNOMEDCT_US_2016_03_01:699537002 SNOMEDCT_US_2016_03_01:703711007 UMLS_CUI:C0878675 disease_ontology DOID:4329 Erdheim-Chester disease DOID:4330 MESH:D015616 SNOMEDCT_US_2016_03_01:127069007 UMLS_CUI:C0019624 disease_ontology DOID:4330 non-Langerhans-cell histiocytosis DOID:4331 MESH:D002054 NCI:C62545 SNOMEDCT_US_2016_03_01:111349000 SNOMEDCT_US_2016_03_01:399165002 UMLS_CUI:C0006430 Orodynia Stomatopyrosis disease_ontology DOID:4331 burning mouth syndrome DOID:4347 MESH:D008210 NCI:C78442 SNOMEDCT_US_2016_03_01:12167004 SNOMEDCT_US_2016_03_01:234109007 SNOMEDCT_US_2016_03_01:234110002 UMLS_CUI:C0024248 Lymph cyst disease_ontology DOID:4347 lymphocele DOID:4362 A female reproductive organ cancer that is located_in the cervix. DOID:4361 ICD10CM:C53 ICD10CM:C53.9 ICD9CM:180 ICD9CM:180.9 MESH:D002583 NCI:C2940 NCI:C9311 OMIM:603956 SNOMEDCT_US_2016_03_01:123841004 SNOMEDCT_US_2016_03_01:188174005 SNOMEDCT_US_2016_03_01:188186008 SNOMEDCT_US_2016_03_01:254885005 SNOMEDCT_US_2016_03_01:363354003 SNOMEDCT_US_2016_03_01:93752005 UMLS_CUI:C0007847 UMLS_CUI:C0007873 cervical neoplasm cervix cancer cervix uteri cancer neoplasm of uterine cervix (disorder) tumor of the Cervix Uteri uterine cervical neoplasm disease_ontology DOID:4362 cervical cancer DOID:437 DOID:443 DOID:444 ICD10CM:G70.0 ICD10CM:G70.00 ICD9CM:358.0 ICD9CM:358.00 MESH:D009157 NCI:C60989 OMIM:254200 SNOMEDCT_US_2016_03_01:155092009 SNOMEDCT_US_2016_03_01:193208002 SNOMEDCT_US_2016_03_01:91637004 UMLS_CUI:C0026896 UMLS_CUI:C1260409 disease_ontology DOID:437 OMIM mapping confirmed by DO. [SN]. myasthenia gravis DOID:4378 A food allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms. MESH:D021183 SNOMEDCT_US_2016_03_01:213021008 SNOMEDCT_US_2016_03_01:91935009 UMLS_CUI:C0559470 allergy to peanuts peanut allergic reaction disease_ontology DOID:4378 peanut allergy DOID:4379 MESH:D021184 SNOMEDCT_US_2016_03_01:395654004 SNOMEDCT_US_2016_03_01:91934008 UMLS_CUI:C0577620 allergy to nuts nut allergic reaction disease_ontology DOID:4379 nut allergy DOID:438 MESH:D020274 NCI:C99383 UMLS_CUI:C0751871 disease_ontology autoimmune nervous system disorder DOID:438 autoimmune disease of the nervous system DOID:439 A neuromuscular disease that is characterized by the disfunction of conduction through the neuromuscular junction. MESH:D020511 SNOMEDCT_US_2016_03_01:128213006 UMLS_CUI:C0751950 disease_ontology DOID:439 neuromuscular junction disease DOID:440 A neuropathy that affect the nerves that control the voluntary muscles. ICD10CM:G70.9 ICD9CM:358 ICD9CM:358.9 MESH:D009468 SNOMEDCT_US_2016_03_01:1664005 SNOMEDCT_US_2016_03_01:193218007 SNOMEDCT_US_2016_03_01:255522009 SNOMEDCT_US_2016_03_01:257277002 UMLS_CUI:C0027868 disease_ontology DOID:440 neuromuscular disease DOID:4411 A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice. DOID:12431 MESH:D016751 SNOMEDCT_US_2016_03_01:7111000119109 UMLS_CUI:C0085293 disease_ontology DOID:4411 hepatitis E DOID:4415 MESH:D018219 NCI:C3739 SNOMEDCT_US_2016_03_01:189769003 SNOMEDCT_US_2016_03_01:189770002 SNOMEDCT_US_2016_03_01:25889007 UMLS_CUI:C0206644 Fibroxanthoma NOS (morphologic abnormality) benign fibrous histiocytoma (morphologic abnormality) fibrous Histiocytoma fibrous histiocytoma NOS (morphologic abnormality) disease_ontology DOID:4415 fibrous histiocytoma DOID:4430 MESH:D013005 NCI:C3379 SNOMEDCT_US_2016_03_01:128642005 SNOMEDCT_US_2016_03_01:253006001 UMLS_CUI:C0037661 Somatostatin cell neoplasm Somatostatin cell tumour disease_ontology DOID:4430 somatostatinoma DOID:4447 MESH:D008269 NCI:C34794 OMIM:153880 SNOMEDCT_US_2016_03_01:193387007 UMLS_CUI:C0024440 disease_ontology DOID:4447 OMIM mapping confirmed by DO. [SN]. cystoid macular edema DOID:4448 A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss. MESH:D008268 MESH:D057135 NCI:C123330 ORDO:279 SNOMEDCT_US_2016_03_01:302891003 SNOMEDCT_US_2016_03_01:422338006 UMLS_CUI:C0024437 Macular degeneration of retina disease_ontology DOID:4448 Xref MGI. macular degeneration DOID:4449 MESH:D008269 NCI:C35468 SNOMEDCT_US_2016_03_01:37231002 UMLS_CUI:C0271051 macular edema disease_ontology DOID:4449 macular retinal edema DOID:445 ICD10CM:E26.81 ICD9CM:255.13 MESH:D001477 NCI:C34412 OMIM:PS601678 SNOMEDCT_US_2016_03_01:190506003 SNOMEDCT_US_2016_03_01:707742001 SNOMEDCT_US_2016_03_01:71275003 UMLS_CUI:C0004775 Aldosteronism with hyperplasia of the adrenal cortex Bartter's syndrome disease_ontology DOID:445 Bartter disease DOID:4450 A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney. EFO:0000681 MESH:D002292 NCI:C9385 OMIM:300854 SNOMEDCT_US_2016_03_01:254915003 SNOMEDCT_US_2016_03_01:41607009 SNOMEDCT_US_2016_03_01:702391001 UMLS_CUI:C0007134 RCC adenocarcinoma of kidney hypernephroma disease_ontology DOID:4450 Xref MGI. renal cell carcinoma DOID:4451 A kidney cancer that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products). NCI:C9384 SNOMEDCT_US_2016_03_01:254915003 UMLS_CUI:C1378703 carcinoma of kidney kidney carcinoma disease_ontology DOID:4451 renal carcinoma DOID:446 An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands. ICD10CM:E26 ICD10CM:E26.9 ICD9CM:255.1 ICD9CM:255.10 MESH:D006929 NCI:C113213 OMIM:605635 OMIM:613677 ORDO:235936 SNOMEDCT_US_2016_03_01:154709005 SNOMEDCT_US_2016_03_01:190506003 SNOMEDCT_US_2016_03_01:190509005 SNOMEDCT_US_2016_03_01:267484005 SNOMEDCT_US_2016_03_01:88213004 UMLS_CUI:C0020428 disease_ontology DOID:446 Xref MGI. hyperaldosteronism DOID:4467 A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope. MESH:D002292 NCI:C4033 SNOMEDCT_US_2016_03_01:188251003 SNOMEDCT_US_2016_03_01:254915003 SNOMEDCT_US_2016_03_01:41607009 UMLS_CUI:C0279702 Clear cell carcinoma of kidney (disorder) clear cell kidney carcinoma conventional (Clear cell) renal cell carcinoma conventional renal cell carcinoma disease_ontology Clear-cell metastatic renal cell carcinoma DOID:4467 MESH:C538445 added from NeuroDevNet [WAK]. renal clear cell carcinoma DOID:447 MESH:D015499 UMLS_CUI:C0035091 inborn renal tubular transport disorder disease_ontology DOID:447 renal tubular transport disease DOID:4471 A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells. MESH:D002292 NCI:C4146 SNOMEDCT_US_2016_03_01:128667008 UMLS_CUI:C1266042 Chromophobe carcinoma of kidney chromophobe adenocarcinoma kidney chromophobe renal cell carcinoma, chromophobe cell disease_ontology DOID:4471 chromophobe renal cell carcinoma DOID:4479 MESH:D011546 NCI:C85034 SNOMEDCT_US_2016_03_01:77098009 UMLS_CUI:C0033805 disease_ontology DOID:4479 pseudohypoaldosteronism DOID:4480 An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone. ICD10CM:Q77.4 MESH:D000130 NCI:C34345 OMIM:100800 SNOMEDCT_US_2016_03_01:190584003 SNOMEDCT_US_2016_03_01:205467007 SNOMEDCT_US_2016_03_01:248299001 SNOMEDCT_US_2016_03_01:268273004 SNOMEDCT_US_2016_03_01:268350005 SNOMEDCT_US_2016_03_01:86268005 UMLS_CUI:C0001080 Achondroplastic physique Chondrodystrophia osteosclerosis congenita disease_ontology DOID:4480 OMIM mapping confirmed by DO. [SN]. achondroplasia DOID:4481 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites. DOID:12089 DOID:14030 DOID:8241 DOID:8242 EFO:0003956 NCI:C34987 OMIM:607154 SNOMEDCT_US_2016_03_01:38103000 UMLS_CUI:C0002103 Non-seasonal allergic rhinitis Perenial allergic rhinitis atopic rhinitis hay fever pollenosis seasonal allergic rhinitis disease_ontology DOID:4481 allergic rhinitis DOID:4483 A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip. MESH:D012220 NCI:C34986 SNOMEDCT_US_2016_03_01:70076002 UMLS_CUI:C0035455 disease_ontology runny nose DOID:4483 rhinitis DOID:4486 NCI:C4282 SNOMEDCT_US_2016_03_01:30383009 UMLS_CUI:C0334515 Mesothelioma, biphasic, malignant (morphologic abnormality) mixed Mesothelioma disease_ontology DOID:4486 malignant biphasic mesothelioma DOID:450 A muscular dystrophy that is characterized by progressive muscle wasting and weakness. ICD10CM:G71.1 ICD9CM:359.2 MESH:D020967 NCI:C84913 SNOMEDCT_US_2016_03_01:155096007 SNOMEDCT_US_2016_03_01:193237003 SNOMEDCT_US_2016_03_01:193240003 SNOMEDCT_US_2016_03_01:267713009 UMLS_CUI:C0553604 disease_ontology DOID:450 myotonic disease DOID:4500 MESH:D007008 NCI:C34939 UMLS_CUI:C1514284 disease_ontology hypopotassemia potassium deficiency disorder DOID:4500 hypokalemia DOID:4515 A thyroid cancer that is located_in the supporting cells of the thyroid. NCI:C6041 UMLS_CUI:C1336756 sarcoma of the Thyroid gland disease_ontology DOID:4515 thyroid sarcoma DOID:452 A gastrointestinal benign neoplasm that is a located_in the salivary glands. MESH:D008949 NCI:C35691 NCI:C8602 OMIM:181030 SNOMEDCT_US_2016_03_01:8360001 UMLS_CUI:C0026277 Pleomorphic adenoma Pleomorphic adenoma (morphologic abnormality) mixed tumor of the Salivary gland disease_ontology DOID:452 pleomorphic adenoma DOID:4531 A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells. MESH:D018277 NCI:C3772 SNOMEDCT_US_2016_03_01:4079000 UMLS_CUI:C0206694 MEC Mucoepidermoid carcinoma (morphologic abnormality) disease_ontology DOID:4531 mucoepidermoid carcinoma DOID:4535 A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles. MESH:D007039 NCI:C34720 OMIM:PS605389 ORDO:55654 SNOMEDCT_US_2016_03_01:53602002 SNOMEDCT_US_2016_03_01:56558005 UMLS_CUI:C0020678 disease_ontology DOID:4535 Xref MGI. hypotrichosis DOID:4540 A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper. ICD10CM:R48.8 MESH:D000381 SNOMEDCT_US_2016_03_01:158321001 SNOMEDCT_US_2016_03_01:206990000 SNOMEDCT_US_2016_03_01:27206009 UMLS_CUI:C0001825 disease_ontology DOID:4540 dysgraphia DOID:4551 MESH:D001005 NCI:C2877 SNOMEDCT_US_2016_03_01:126849006 UMLS_CUI:C0003463 anal neoplasm anal tumors neoplasm of anus disease_ontology DOID:4551 anus neoplasm DOID:4552 A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm. MESH:D018287 NCI:C3780 SNOMEDCT_US_2016_03_01:189551005 SNOMEDCT_US_2016_03_01:22687000 UMLS_CUI:C0206704 disease_ontology DOID:4552 large cell carcinoma DOID:4556 NCI:C4450 SNOMEDCT_US_2016_03_01:254629004 UMLS_CUI:C0345958 large cell carcinoma of lung (disorder) large cell lung carcinoma disease_ontology DOID:4556 lung large cell carcinoma DOID:4606 A biliary tract cancer that is located_in the bile duct. DOID:10019 ICD10CM:C24.0 ICD9CM:156.1 MESH:D001650 NCI:C2898 NCI:C7483 SNOMEDCT_US_2016_03_01:154473009 SNOMEDCT_US_2016_03_01:187787007 SNOMEDCT_US_2016_03_01:363416002 SNOMEDCT_US_2016_03_01:93790004 UMLS_CUI:C0005396 UMLS_CUI:C0153453 Ca extrahepatic bile ducts bile duct tumor malignant neoplasm of the extrahepatic bile duct disease_ontology DOID:4606 bile duct cancer DOID:4607 A gastrointestinal system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct. DOID:8092 ICD10CM:C24.9 ICD9CM:156.9 MESH:D001661 SNOMEDCT_US_2016_03_01:126853008 SNOMEDCT_US_2016_03_01:363415003 SNOMEDCT_US_2016_03_01:93688006 UMLS_CUI:C0005426 UMLS_CUI:C0750952 malignant tumour of biliary tract disease_ontology DOID:4607 biliary tract cancer DOID:461 DOID:2692 MESH:D009379 MESH:D019042 NCI:C4063 SNOMEDCT_US_2016_03_01:115228006 SNOMEDCT_US_2016_03_01:126616000 SNOMEDCT_US_2016_03_01:134329004 SNOMEDCT_US_2016_03_01:189786009 SNOMEDCT_US_2016_03_01:189801005 UMLS_CUI:C0027664 UMLS_CUI:C0282606 Myomatous neoplasm Myomatous tumor muscle neoplasm muscle tissue neoplasm neoplasm of muscle (disorder) disease_ontology DOID:461 muscle benign neoplasm DOID:4610 A gastrointestinal system benign neoplasm that is located_in the intestine. MESH:D007414 NCI:C3141 SNOMEDCT_US_2016_03_01:126769007 UMLS_CUI:C0021841 intestinal tumors intestine growth neoplasm of intestinal tract disease_ontology DOID:4610 intestinal benign neoplasm DOID:4621 A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies. ICD10CM:Q04.2 MESH:D016142 NCI:C74988 ORDO:2162 SNOMEDCT_US_2016_03_01:30915001 SNOMEDCT_US_2016_03_01:44519006 UMLS_CUI:C0079541 Holoprosencephaly sequence (disorder) disease_ontology DOID:4621 Xref MGI. OMIM mapping confirmed by DO. [SN]. holoprosencephaly DOID:4624 A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet. ICD10CM:Q78.4 MESH:D004687 NCI:C3213 OMIM:166000 ORDO:296 SNOMEDCT_US_2016_03_01:205470006 SNOMEDCT_US_2016_03_01:234135008 SNOMEDCT_US_2016_03_01:46041001 UMLS_CUI:C0024454 DYSCHONDROPLASIA ENCHONDROMATOSIS, MULTIPLE Enchondromatosis with haemangiomata Kast's syndrome OSTEOCHONDROMATOSIS disease_ontology DOID:4624 OMIM mapping confirmed by DO. [SN]. Ollier disease DOID:4626 ICD10CM:Q04.3 MESH:D006832 NCI:C98949 SNOMEDCT_US_2016_03_01:30023002 UMLS_CUI:C0020225 disease_ontology DOID:4626 hydranencephaly DOID:4639 NCI:C27135 SNOMEDCT_US_2016_03_01:48573006 UMLS_CUI:C0392051 Suppurative lymphadenopathy (disorder) disease_ontology DOID:4639 suppurative lymphadenitis DOID:4645 DOID:770 ICD10CM:C69.2 ICD9CM:190.5 MESH:D019572 NCI:C3216 NCI:C4800 SNOMEDCT_US_2016_03_01:127002001 SNOMEDCT_US_2016_03_01:363465007 SNOMEDCT_US_2016_03_01:93987004 UMLS_CUI:C0024622 UMLS_CUI:C0524801 Retinal tumor malignant Retinal neoplasm malignant neoplasm of retina malignant tumor of retina (disorder) neoplasm of retina disease_ontology DOID:4645 retinal cancer DOID:4664 ICD10CM:H16.12 ICD9CM:370.23 SNOMEDCT_US_2016_03_01:51286002 UMLS_CUI:C0155077 disease_ontology DOID:4664 filamentary keratitis DOID:4674 A sex differentiation disease that is characterized by the partial or complete inability of the cell to respond to androgens in individuals with a karyotype of 46,XY resulting in female physical traits but male genetic makeup. DOID:4672 ICD10CM:E34.5 ICD10CM:E34.50 ICD10CM:E34.51 ICD9CM:259.5 ICD9CM:259.51 MESH:D013734 NCI:C120191 NCI:C27226 OMIM:300068 SNOMEDCT_US_2016_03_01:12313004 SNOMEDCT_US_2016_03_01:154713003 SNOMEDCT_US_2016_03_01:190562003 SNOMEDCT_US_2016_03_01:237802009 SNOMEDCT_US_2016_03_01:267486007 SNOMEDCT_US_2016_03_01:368851000119102 SNOMEDCT_US_2016_03_01:52832001 UMLS_CUI:C0039585 UMLS_CUI:C0936016 Androgen resistance syndrome (disorder) Androgen-Insensitivity Syndrome Feminisation - testicular Goldberg - Maxwell syndrome Goldberg-Maxwell syndrome testicular Feminization syndrome testicular feminization testicular feminization (disorder) disease_ontology DOID:4674 OMIM mapping confirmed by DO. [SN]. androgen insensitivity syndrome DOID:4676 ICD10CM:N19 MESH:D014511 SNOMEDCT_US_2016_03_01:197656003 SNOMEDCT_US_2016_03_01:266616000 SNOMEDCT_US_2016_03_01:44730006 UMLS_CUI:C0041948 UREMIA OF renal ORIGIN disease_ontology DOID:4676 uremia DOID:4677 A corneal disease that is characterized by inflammation of the cornea. ICD10CM:H16 ICD10CM:H16.9 ICD9CM:370 ICD9CM:370.9 MESH:D007634 NCI:C26805 SNOMEDCT_US_2016_03_01:155151002 SNOMEDCT_US_2016_03_01:155155006 SNOMEDCT_US_2016_03_01:193757003 SNOMEDCT_US_2016_03_01:193793001 SNOMEDCT_US_2016_03_01:267730006 SNOMEDCT_US_2016_03_01:5888003 UMLS_CUI:C0022568 disease_ontology DOID:4677 keratitis DOID:4680 NCI:C5164 UMLS_CUI:C1334708 Metaplastic carcinoma of the breast disease_ontology metaplastic carcinoma of breast DOID:4680 breast metaplastic carcinoma DOID:4692 A globe disease that is characterized by inflammation of the inside of the eye. MESH:D009877 NCI:C34586 SNOMEDCT_US_2016_03_01:123052006 SNOMEDCT_US_2016_03_01:128295000 SNOMEDCT_US_2016_03_01:1847009 SNOMEDCT_US_2016_03_01:82255004 UMLS_CUI:C0014236 disease_ontology DOID:4692 endophthalmitis DOID:47 ICD10CM:N42.9 ICD9CM:602.9 MESH:D011469 NCI:C26865 SNOMEDCT_US_2016_03_01:197979000 SNOMEDCT_US_2016_03_01:30281009 UMLS_CUI:C0033575 disease_ontology DOID:47 prostate disease DOID:4706 A brain cancer that is located_in the infratentorial region. DOID:4789 ICD10CM:C71.7 MESH:D015192 NCI:C3139 NCI:C4966 UMLS_CUI:C0021432 UMLS_CUI:C0751593 brain neoplasm, Infratentorial malignant Infratentorial tumors disease_ontology DOID:4706 infratentorial cancer DOID:471 NCI:C4905 SNOMEDCT_US_2016_03_01:189195009 SNOMEDCT_US_2016_03_01:254773009 SNOMEDCT_US_2016_03_01:93471006 UMLS_CUI:C0687140 Angioma of the skin Angiomatous naevus of skin hemangioma of skin (disorder) disease_ontology DOID:471 skin hemangioma DOID:4723 MESH:D019585 SNOMEDCT_US_2016_03_01:433691000124104 UMLS_CUI:C0524812 disease_ontology DOID:4723 intracranial hypotension DOID:4724 MESH:D001929 SNOMEDCT_US_2016_03_01:2032001 SNOMEDCT_US_2016_03_01:85974009 UMLS_CUI:C1527311 intracranial swelling wet brain disease_ontology DOID:4724 brain edema DOID:4737 A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. DOID:10133 DOID:144 ICD10CM:F45 ICD10CM:F45.0 ICD10CM:F45.9 ICD9CM:300.8 ICD9CM:300.81 ICD9CM:306.8 MESH:D013001 NCI:C34956 SNOMEDCT_US_2016_03_01:154892001 SNOMEDCT_US_2016_03_01:191743005 SNOMEDCT_US_2016_03_01:192035008 SNOMEDCT_US_2016_03_01:192430009 SNOMEDCT_US_2016_03_01:192431008 SNOMEDCT_US_2016_03_01:192437007 SNOMEDCT_US_2016_03_01:31297008 SNOMEDCT_US_2016_03_01:397795007 SNOMEDCT_US_2016_03_01:397826007 SNOMEDCT_US_2016_03_01:397923000 SNOMEDCT_US_2016_03_01:60368009 SNOMEDCT_US_2016_03_01:9514005 UMLS_CUI:C0029824 UMLS_CUI:C0037650 UMLS_CUI:C0520482 physiological malfunction arising from mental factor psychophysiologic disorder psychosomatic disorder disease_ontology DOID:4737 somatoform disorder DOID:4752 DOID:11510 MESH:D012791 MESH:D019578 NCI:C84909 NCI:C85066 OMIM:146500 SNOMEDCT_US_2016_03_01:16576004 SNOMEDCT_US_2016_03_01:230297002 UMLS_CUI:C0037019 UMLS_CUI:C0393571 Multiple system atrophy (disorder) Shy-Drager syndrome disease_ontology DOID:4752 OMIM mapping confirmed by DO. [LS]. multiple system atrophy DOID:4757 NCI:C6358 SNOMEDCT_US_2016_03_01:702406000 UMLS_CUI:C3840076 Sex Cord-Stromal tumor of testis disease_ontology DOID:4757 sex cord-stromal neoplasm DOID:48 A reproductive system disease that affects male reproductive organs. ICD10CM:N50.9 ICD9CM:600-608.99 ICD9CM:608.9 MESH:D005832 SNOMEDCT_US_2016_03_01:155905004 SNOMEDCT_US_2016_03_01:155933004 SNOMEDCT_US_2016_03_01:155945008 SNOMEDCT_US_2016_03_01:198089001 SNOMEDCT_US_2016_03_01:198553004 SNOMEDCT_US_2016_03_01:64557000 UMLS_CUI:C0017412 disease_ontology DOID:48 male reproductive system disease DOID:480 MESH:D009069 NCI:C116757 SNOMEDCT_US_2016_03_01:60342002 UMLS_CUI:C0026650 disease_ontology DOID:480 movement disease DOID:4810 A xanthomatosis that is characterized by a deficiency in the production of the bile acid, chenodeoxycholic acid that has_material_basis_in autosomal recessive inheritance and results in cholestanol deposition in the brain and other tissues and with elevated levels of cholesterol in plasma. MESH:D019294 NCI:C84628 OMIM:213700 SNOMEDCT_US_2016_03_01:63246000 UMLS_CUI:C0238052 Cholestanol storage disease (disorder) disease_ontology DOID:4810 OMIM mapping confirmed by DO. [SN]. cerebrotendinous xanthomatosis DOID:4829 NCI:C9133 UMLS_CUI:C0279557 Adenosquamous lung carcinoma disease_ontology DOID:4829 adenosquamous cell lung carcinoma DOID:4830 A squamous cell carcinoma that contains squamous cells and gland-like cells. MESH:D018196 NCI:C3727 SNOMEDCT_US_2016_03_01:403902008 SNOMEDCT_US_2016_03_01:59367005 UMLS_CUI:C0206623 Adenosquamous carcinoma (morphologic abnormality) Adenosquamous cell carcinoma (disorder) mixed adenocarcinoma and squamous carcinoma disease_ontology DOID:4830 adenosquamous carcinoma DOID:4838 A carcinoma that derives_from myoepithelial cells. NCI:C7596 SNOMEDCT_US_2016_03_01:128884000 SNOMEDCT_US_2016_03_01:24292006 UMLS_CUI:C0334699 disease_ontology DOID:4838 myoepithelial carcinoma DOID:4843 MESH:D018315 NCI:C3795 SNOMEDCT_US_2016_03_01:189910001 SNOMEDCT_US_2016_03_01:4553004 UMLS_CUI:C0206725 Subependymal astrocytoma Subependymal astrocytoma NOS WHO grade I Ependymal tumor mixed subependymoma-ependymoma disease_ontology DOID:4843 subependymal glioma DOID:4844 MESH:D004806 NCI:C3017 SNOMEDCT_US_2016_03_01:189913004 SNOMEDCT_US_2016_03_01:253066003 SNOMEDCT_US_2016_03_01:443643007 SNOMEDCT_US_2016_03_01:57706008 UMLS_CUI:C0014474 WHO grade II Ependymal tumor epithelial ependymoma disease_ontology DOID:4844 benign ependymoma DOID:4890 A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years. DOID:0050326 MESH:D020190 NCI:C84796 OMIM:254770 OMIM:607631 OMIM:608816 OMIM:611364 OMIM:614280 ORDO:862 SNOMEDCT_US_2016_03_01:6204001 UMLS_CUI:C0270853 Janz syndrome disease_ontology DOID:4890 Xref MGI. OMIM mapping confirmed by DO. [SN]. juvenile myoclonic epilepsy DOID:4896 A bile duct carcinoma that derives_from epithelial cells of glandular origin. NCI:C27813 SNOMEDCT_US_2016_03_01:70179006 UMLS_CUI:C1370800 disease_ontology DOID:4896 bile duct adenocarcinoma DOID:4897 A bile duct cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. MESH:D001650 NCI:C27814 SNOMEDCT_US_2016_03_01:70179006 UMLS_CUI:C0740277 disease_ontology DOID:4897 bile duct carcinoma DOID:4905 A pancreas cancer that derives_from epithelial cells located_in the pancreas. EFO:0002618 MESH:C562463 NCI:C3850 OMIM:260350 SNOMEDCT_US_2016_03_01:154475002 SNOMEDCT_US_2016_03_01:255089009 SNOMEDCT_US_2016_03_01:372142002 SNOMEDCT_US_2016_03_01:93938001 UMLS_CUI:C0235974 Exocrine pancreas carcinoma carcinoma of pancreas carcinoma of pancreas (disorder) disease_ontology Pancreatic carcinoma, familial exocrine cancer DOID:4905 OMIM mapping confirmed by DO. [SN]. pancreatic carcinoma DOID:4906 A small intestine carcinoma that derives_from epithelial cells of glandular origin. NCI:C7888 SNOMEDCT_US_2016_03_01:424440001 UMLS_CUI:C0278803 small intestinal adenocarcinoma disease_ontology adenocarcinoma of small Intestine DOID:4906 small intestine adenocarcinoma DOID:4907 A small intestine cancer that develops from epithelial cells and is located_in the small intestine. NCI:C7724 UMLS_CUI:C0238196 small intestinal carcinoma disease_ontology cancer of the small bowel small bowel cancer DOID:4907 small intestine carcinoma DOID:4914 An esophageal carcinoma that derives_from epithelial cells of glandular origin. MESH:C562730 NCI:C4025 SNOMEDCT_US_2016_03_01:276803003 UMLS_CUI:C0279628 Oesophageal adenocarcinoma NOS adenocarcinoma of esophagus (disorder) disease_ontology adenocarcinoma of esophagus DOID:4914 esophagus adenocarcinoma DOID:4919 DOID:12343 ICD10CM:C65 ICD9CM:189.1 NCI:C6142 NCI:C7525 SNOMEDCT_US_2016_03_01:188254006 SNOMEDCT_US_2016_03_01:363457009 SNOMEDCT_US_2016_03_01:93985007 UMLS_CUI:C0153618 UMLS_CUI:C1335749 carcinoma of kidney Pelvis malignant neoplasm of renal pelvis malignant neoplasm of renal pelvis NOS (disorder) malignant renal Pelvis neoplasm malignant tumor of renal pelvis (disorder) renal pelvis cancer disease_ontology DOID:4919 renal pelvis carcinoma DOID:4926 MESH:D002282 NCI:C2923 SNOMEDCT_US_2016_03_01:112677002 SNOMEDCT_US_2016_03_01:307595008 SNOMEDCT_US_2016_03_01:36310008 SNOMEDCT_US_2016_03_01:373627005 UMLS_CUI:C0007120 Alveolar adenocarcinoma (morphologic abnormality) Bronchioalveolar lung carcinoma Bronchiolo-alveolar adenocarcinoma (morphologic abnormality) Bronchioloalveolar adenocarcinoma Bronchioloalveolar carcinoma (disorder) disease_ontology DOID:4926 bronchiolo-alveolar adenocarcinoma DOID:4929 An adenocarcinoma that derives_from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma. MESH:D000230 NCI:C65192 SNOMEDCT_US_2016_03_01:4631006 UMLS_CUI:C0205645 tubular adenocarcinoma (morphologic abnormality) tubular carcinoma disease_ontology DOID:4929 tubular adenocarcinoma DOID:4931 A nasal cavity cancer that_has_material_basis_in epithelial cells. NCI:C9336 UMLS_CUI:C1377785 cancer of nasal cavity disease_ontology carcinoma of nasal cavity DOID:4931 nasal cavity carcinoma DOID:4933 An apocrine sweat gland cancer that derives_from epithelial cells of glandular origin. DOID:5571 SNOMEDCT_US_2016_03_01:57141000 UMLS_CUI:C0334346 Apocrine adenocarcinoma (morphologic abnormality) Apocrine carcinoma apocrine gland carcinoma carcinoma of the Apocrine gland disease_ontology DOID:4933 apocrine adenocarcinoma DOID:4934 NCI:C6800 UMLS_CUI:C1334561 malignant Apocrine tumor disease_ontology DOID:4934 apocrine sweat gland cancer DOID:4939 An ureter cancer that is located_in the ureter. NCI:C8993 UMLS_CUI:C0600079 ureteral carcinoma disease_ontology DOID:4939 ureter carcinoma DOID:4943 MESH:D065311 NCI:C4123 SNOMEDCT_US_2016_03_01:51642000 UMLS_CUI:C0334276 disease_ontology DOID:4943 adenocarcinoma in situ DOID:4947 A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells. DOID:5249 ICD10CM:C22.1 MESH:D018281 NCI:C4436 NCI:C8265 SNOMEDCT_US_2016_03_01:312104005 SNOMEDCT_US_2016_03_01:70179006 UMLS_CUI:C0206698 UMLS_CUI:C0280725 adult primary Cholangiocarcinoma adult primary cholangiocellular carcinoma cholangiosarcoma disease_ontology DOID:4947 cholangiocarcinoma DOID:4948 A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. NCI:C3844 SNOMEDCT_US_2016_03_01:187782001 SNOMEDCT_US_2016_03_01:255085003 SNOMEDCT_US_2016_03_01:372140005 SNOMEDCT_US_2016_03_01:93810008 UMLS_CUI:C0235782 cancer of the gallbladder carcinoma gallbladder carcinoma of gallbladder (disorder) disease_ontology DOID:4948 gallbladder carcinoma DOID:4952 A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems. ICD10CM:G14 MESH:D016262 SNOMEDCT_US_2016_03_01:31097004 SNOMEDCT_US_2016_03_01:367094007 UMLS_CUI:C0080040 Postpolio syndrome disease_ontology DOID:4952 postpoliomyelitis syndrome DOID:4953 A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis. ICD10CM:A80 ICD10CM:A80.9 ICD9CM:045 ICD9CM:045.9 MESH:D011051 NCI:C35550 SNOMEDCT_US_2016_03_01:154320008 SNOMEDCT_US_2016_03_01:186475007 SNOMEDCT_US_2016_03_01:186481004 SNOMEDCT_US_2016_03_01:187390004 SNOMEDCT_US_2016_03_01:266189002 SNOMEDCT_US_2016_03_01:367318001 SNOMEDCT_US_2016_03_01:398102009 SNOMEDCT_US_2016_03_01:398256009 SNOMEDCT_US_2016_03_01:54839009 UMLS_CUI:C0032371 disease_ontology DOID:4953 poliomyelitis DOID:496 NCI:C4754 SNOMEDCT_US_2016_03_01:128769003 SNOMEDCT_US_2016_03_01:134304005 SNOMEDCT_US_2016_03_01:403967000 UMLS_CUI:C1304508 SCH spindle cell angioendothelioma spindle cell hemangioendothelioma [dup] (morphologic abnormality) spindle cell hemangioma (disorder) disease_ontology DOID:496 spindle cell hemangioma DOID:4960 A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow. DOID:2356 DOID:2761 EFO:0004251 ICD10CM:D47.1 MESH:D009196 SNOMEDCT_US_2016_03_01:128925001 SNOMEDCT_US_2016_03_01:188772004 SNOMEDCT_US_2016_03_01:20921005 SNOMEDCT_US_2016_03_01:414794006 SNOMEDCT_US_2016_03_01:425333006 UMLS_CUI:C0027022 bone Marrow tumor bone marrow neoplasm malignant bone Marrow tumor malignant neoplasm of bone marrow disease_ontology DOID:4960 bone marrow cancer DOID:4961 MESH:D001855 NCI:C34433 SNOMEDCT_US_2016_03_01:127035006 UMLS_CUI:C0005956 bone marrow disorder disease_ontology DOID:4961 bone marrow disease DOID:4970 An agnosia that results in the loss of the ability to consciously recognize familiar faces. ICD10CM:R48.3 MESH:D020238 NCI:C85031 SNOMEDCT_US_2016_03_01:18358003 UMLS_CUI:C0234512 disease_ontology DOID:4970 prosopagnosia DOID:4971 A myeloid neoplasm that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue. DOID:5737 ICD10CM:D47.4 ICD10CM:D75.81 ICD9CM:238.76 ICD9CM:289.83 MESH:D055728 NCI:C2862 NCI:C3248 OMIM:254450 SNOMEDCT_US_2016_03_01:128843003 SNOMEDCT_US_2016_03_01:154841009 SNOMEDCT_US_2016_03_01:188773009 SNOMEDCT_US_2016_03_01:22265001 SNOMEDCT_US_2016_03_01:267572005 SNOMEDCT_US_2016_03_01:307651005 SNOMEDCT_US_2016_03_01:52967002 SNOMEDCT_US_2016_03_01:78956007 UMLS_CUI:C0001815 UMLS_CUI:C0026987 Agnogenic myeloid metaplasia Aleukemic myelosis Megakaryocytic myelosclerosis bone Marrow Fibrosis myelosclerosis primary myelofibrosis disease_ontology DOID:4971 OMIM mapping confirmed by DO. [SN]. myelofibrosis DOID:4976 MESH:D004604 NCI:C34569 SNOMEDCT_US_2016_03_01:155485008 SNOMEDCT_US_2016_03_01:240820001 SNOMEDCT_US_2016_03_01:266334008 UMLS_CUI:C0013882 Elephantiasis NOS disease_ontology DOID:4976 elephantiasis DOID:4977 MESH:D008209 NCI:C3207 SNOMEDCT_US_2016_03_01:155485008 SNOMEDCT_US_2016_03_01:195486001 SNOMEDCT_US_2016_03_01:234097001 SNOMEDCT_US_2016_03_01:266334008 SNOMEDCT_US_2016_03_01:30213001 UMLS_CUI:C0024236 Lymphatic edema (morphologic abnormality) Lymphoedema NOS disease_ontology DOID:4977 lymphedema DOID:4988 MESH:D019512 SNOMEDCT_US_2016_03_01:445507008 UMLS_CUI:C0376670 disease_ontology DOID:4988 alcoholic pancreatitis DOID:4989 EFO:0000278 ICD10CM:K85.9 MESH:D010195 NCI:C3306 SNOMEDCT_US_2016_03_01:197461009 SNOMEDCT_US_2016_03_01:393591004 SNOMEDCT_US_2016_03_01:75694006 UMLS_CUI:C0030305 disease_ontology DOID:4989 pancreatitis DOID:4990 A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms. ICD10CM:G25.0 MESH:D020329 OMIM:190300 OMIM:602134 OMIM:611456 OMIM:614782 ORDO:862 SNOMEDCT_US_2016_03_01:192839001 SNOMEDCT_US_2016_03_01:609558009 SNOMEDCT_US_2016_03_01:632009 UMLS_CUI:C0270736 benign essential tremor essential hereditary tremor shaky hand syndrome disease_ontology DOID:4990 Xref MGI. essential tremor DOID:4998 An autosomal dominant disease that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose. MESH:D015826 NCI:C75118 OMIM:150230 SNOMEDCT_US_2016_03_01:239017000 SNOMEDCT_US_2016_03_01:41069008 UMLS_CUI:C0023003 Langer-Giedion syndrome Trichorhinophalangeal dysplasia type II disease_ontology DOID:4998 OMIM mapping confirmed by DO. [SN]. trichorhinophalangeal syndrome type II DOID:50 An endocrine system disease that is located_in the thyroid. ICD10CM:E00-E07 ICD10CM:E07.9 ICD9CM:240-246.99 ICD9CM:246.9 MESH:D013959 NCI:C26893 SNOMEDCT_US_2016_03_01:14304000 SNOMEDCT_US_2016_03_01:154649009 SNOMEDCT_US_2016_03_01:190232008 SNOMEDCT_US_2016_03_01:190311002 SNOMEDCT_US_2016_03_01:191036006 UMLS_CUI:C0040128 disease_ontology DOID:50 thyroid gland disease DOID:5032 An endocrine gland located_in the pineal gland located in the brain. DOID:1662 DOID:4859 ICD10CM:C75.3 ICD9CM:194.4 MESH:D010871 NCI:C3328 NCI:C3573 NCI:C6965 SNOMEDCT_US_2016_03_01:127026004 SNOMEDCT_US_2016_03_01:359619007 SNOMEDCT_US_2016_03_01:363483004 SNOMEDCT_US_2016_03_01:47598005 SNOMEDCT_US_2016_03_01:93962006 UMLS_CUI:C0031941 UMLS_CUI:C0153655 UMLS_CUI:C1412004 Pinealoma Pineocytic tumor malignant Pineal Region tumor malignant tumor of pineal gland neoplasm of pineal gland neoplasm of the Pineal Region pineal body neoplasm tumor of the pineal region disease_ontology DOID:5032 pineal gland cancer DOID:5041 A gastrointestinal system cancer that is located_in the esophagus. DOID:10291 DOID:10292 DOID:10448 DOID:1102 DOID:1104 ICD10CM:C15.3 ICD10CM:C15.4 ICD10CM:C15.5 ICD9CM:150.2 ICD9CM:150.3 ICD9CM:150.4 ICD9CM:150.5 ICD9CM:150.8 MESH:D004938 NCI:C3028 NCI:C3533 NCI:C3534 NCI:C3535 NCI:C4764 OMIM:133239 SNOMEDCT_US_2016_03_01:126817006 SNOMEDCT_US_2016_03_01:154443000 SNOMEDCT_US_2016_03_01:154444006 SNOMEDCT_US_2016_03_01:187724003 SNOMEDCT_US_2016_03_01:187725002 SNOMEDCT_US_2016_03_01:187726001 SNOMEDCT_US_2016_03_01:187727005 SNOMEDCT_US_2016_03_01:187729008 SNOMEDCT_US_2016_03_01:269523008 SNOMEDCT_US_2016_03_01:269524002 SNOMEDCT_US_2016_03_01:93656003 SNOMEDCT_US_2016_03_01:93877002 SNOMEDCT_US_2016_03_01:93895004 SNOMEDCT_US_2016_03_01:94119000 UMLS_CUI:C0014859 UMLS_CUI:C0153413 UMLS_CUI:C0153414 UMLS_CUI:C0153415 UMLS_CUI:C0153416 UMLS_CUI:C0496775 Ca lower third oesophagus Ca middle third oesophagus esophagus cancer malignant neoplasm of distal third of esophagus malignant neoplasm of lower third of oesophagus malignant neoplasm of middle third of oesophagus malignant neoplasm of proximal third of esophagus malignant neoplasm of upper third esophagus malignant tumor of Distal Third of esophagus malignant tumor of Proximal Third of esophagus malignant tumor of abdominal esophagus malignant tumor of the middle Third of the esophagus disease_ontology DOID:5041 esophageal cancer DOID:5052 A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain. DOID:0050062 DOID:0050064 ICD10CM:A24.9 ICD9CM:025 MESH:D008554 SNOMEDCT_US_2016_03_01:187306003 SNOMEDCT_US_2016_03_01:34458001 SNOMEDCT_US_2016_03_01:428111003 UMLS_CUI:C0025229 Nightcliff gardener's disease Pseudoglanders Whitmore's disease acute and fulminating melioidosis subacute and chronic melioidosis disease_ontology DOID:5052 melioidosis DOID:5062 A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences. MESH:D010623 SNOMEDCT_US_2016_03_01:7071007 UMLS_CUI:C0031391 PCP abuse Phencyclidine abuse disease_ontology DOID:5062 phencyclidine abuse DOID:507 A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred. ICD9CM:309 ICD9CM:309.9 SNOMEDCT_US_2016_03_01:17226007 SNOMEDCT_US_2016_03_01:192068001 SNOMEDCT_US_2016_03_01:268781004 SNOMEDCT_US_2016_03_01:367487002 SNOMEDCT_US_2016_03_01:63608001 UMLS_CUI:C0040701 adjustment disease adjustment reaction disease_ontology DOID:507 adjustment disorder DOID:5076 MESH:D005910 NCI:C3903 SNOMEDCT_US_2016_03_01:22217002 SNOMEDCT_US_2016_03_01:443937008 UMLS_CUI:C0259783 mixed Neuroglial tumor mixed glioma (morphologic abnormality) mixed gliomas disease_ontology DOID:5076 mixed glioma DOID:5077 MESH:D001254 NCI:C3696 SNOMEDCT_US_2016_03_01:1586004 SNOMEDCT_US_2016_03_01:449799008 UMLS_CUI:C0205768 SEGA Subependymal giant cell astrocytoma (morphologic abnormality) disease_ontology DOID:5077 subependymal giant cell astrocytoma DOID:5078 A cell type benign neoplasm that has_material_basis_in glial-type cells. DOID:5606 DOID:5607 MESH:D018303 NCI:C27362 NCI:C27363 NCI:C3788 SNOMEDCT_US_2016_03_01:87191000119100 SNOMEDCT_US_2016_03_01:89880005 UMLS_CUI:C0206716 UMLS_CUI:C1332202 UMLS_CUI:C1332969 CNS ganglioglioma adult ganglioglioma childhood ganglioglioma disease_ontology DOID:5078 ganglioglioma DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 SNOMEDCT_US_2016_03_01:155809006 SNOMEDCT_US_2016_03_01:197309008 SNOMEDCT_US_2016_03_01:19943007 SNOMEDCT_US_2016_03_01:235891006 SNOMEDCT_US_2016_03_01:266537000 UMLS_CUI:C0023890 Cirrhosis cirrhosis of liver disease_ontology DOID:5082 liver cirrhosis DOID:5093 An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall. DOID:3937 ICD10CM:C76.1 ICD9CM:195.1 MESH:D013899 NCI:C3406 NCI:C3576 SNOMEDCT_US_2016_03_01:188361007 SNOMEDCT_US_2016_03_01:188365003 SNOMEDCT_US_2016_03_01:255058005 UMLS_CUI:C0039981 UMLS_CUI:C0153661 Thoracic tumor thorax cancer thorax neoplasm tumor of thorax disease_ontology DOID:5093 thoracic cancer DOID:5100 NCI:C27065 SNOMEDCT_US_2016_03_01:155260002 SNOMEDCT_US_2016_03_01:194327004 SNOMEDCT_US_2016_03_01:232250008 SNOMEDCT_US_2016_03_01:300195001 SNOMEDCT_US_2016_03_01:68996008 UMLS_CUI:C0271428 disease_ontology DOID:5100 middle ear disease DOID:5113 MESH:D003677 UMLS_CUI:C0011156 disease_ontology DOID:5113 nutritional deficiency disease DOID:5154 A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment. MESH:D001890 SNOMEDCT_US_2016_03_01:76851008 UMLS_CUI:C0006023 Enzootic encephalomyelitis disease_ontology DOID:5154 borna disease DOID:5160 MESH:D001162 SNOMEDCT_US_2016_03_01:361133006 SNOMEDCT_US_2016_03_01:60625000 UMLS_CUI:C0003851 Arteriosclerosis obliterans (disorder) Arteriosclerosis obliterans (disorder) [Ambiguous] disease_ontology DOID:5160 arteriosclerosis obliterans DOID:5165 An uterine corpus cancer that is located_in the muscles of the uterus or located_in other tissues that support the uterus. NCI:C6339 SNOMEDCT_US_2016_03_01:254877001 UMLS_CUI:C0338113 sarcoma of Corpus Uteri sarcoma of uterus (disorder) disease_ontology DOID:5165 uterine corpus sarcoma DOID:5166 MESH:D036821 SNOMEDCT_US_2016_03_01:446887007 SNOMEDCT_US_2016_03_01:68738004 UMLS_CUI:C0334695 endometrial Stromal neoplasm endometrial stromal tumor (morphologic abnormality) disease_ontology DOID:5166 endometrial stromal tumor DOID:5176 NCI:C6951 UMLS_CUI:C1335062 Nonanaplastic renal Wilm's tumor disease_ontology nonanaplastic renal wilms tumor DOID:5176 renal Wilms' tumor DOID:5199 ICD9CM:593.4 SNOMEDCT_US_2016_03_01:197807001 UMLS_CUI:C0029866 disease_ontology DOID:5199 ureteral obstruction DOID:520 An artery disease that is characterized by degeneration of the cells composing the aortic wall. MESH:D001018 NCI:C101253 SNOMEDCT_US_2016_03_01:47040006 UMLS_CUI:C0003493 aortic disorder disorder of the aorta (disorder) disease_ontology DOID:520 aortic disease DOID:5200 ICD10CM:N13.9 ICD9CM:599.6 ICD9CM:599.60 NCI:C3675 NCI:C79805 SNOMEDCT_US_2016_03_01:197936002 SNOMEDCT_US_2016_03_01:266567006 SNOMEDCT_US_2016_03_01:266636004 SNOMEDCT_US_2016_03_01:7163005 UMLS_CUI:C0178879 Obstructive Uropathy urinary obstruction disease_ontology DOID:5200 urinary tract obstruction DOID:5204 A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis. ICD10CM:E74.19 MESH:D015319 OMIM:229700 SNOMEDCT_US_2016_03_01:28183005 UMLS_CUI:C0016756 fructose 1 phosphate aldolase deficiency fructose-1,6-diphosphatase deficiency disease_ontology DOID:5204 OMIM mapping confirmed by DO. [SN]. fructose-1,6-bisphosphatase deficiency DOID:5212 A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids. MESH:D018981 NCI:C84615 OMIM:212066 OMIM:PS212065 ORDO:137 SNOMEDCT_US_2016_03_01:238049009 UMLS_CUI:C0282577 carbohydrate-deficient glycoprotein syndrome disease_ontology DOID:5212 Xref MGI. congenital disorder of glycosylation DOID:5221 NCI:C36071 UMLS_CUI:C1167650 disease_ontology DOID:5221 chronic polyneuropathy DOID:5223 MESH:D007246 NCI:C3836 SNOMEDCT_US_2016_03_01:15296000 SNOMEDCT_US_2016_03_01:162186008 SNOMEDCT_US_2016_03_01:289179008 SNOMEDCT_US_2016_03_01:8619003 UMLS_CUI:C0021359 disease_ontology DOID:5223 infertility DOID:5238 NCI:C6529 UMLS_CUI:C1332532 disease_ontology DOID:5238 benign perivascular tumor DOID:526 A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands. ICD10CM:B20 ICD10CM:B20-B20 ICD9CM:042 ICD9CM:042-042.99 MESH:D015658 NCI:C3108 SNOMEDCT_US_2016_03_01:123321001 SNOMEDCT_US_2016_03_01:186705005 SNOMEDCT_US_2016_03_01:187438009 SNOMEDCT_US_2016_03_01:187453001 SNOMEDCT_US_2016_03_01:86406008 UMLS_CUI:C0019693 HIV infection disease_ontology DOID:526 human immunodeficiency virus infectious disease DOID:5263 NCI:C5234 UMLS_CUI:C1335163 leiomyosarcoma of Ovary disease_ontology DOID:5263 ovary leiomyosarcoma DOID:5272 A sarcoma and malignant tumor of small intestine that is located_in the small intestine. NCI:C5335 UMLS_CUI:C1336007 sarcoma of the Small Intestine disease_ontology DOID:5272 small intestinal sarcoma DOID:5280 NCI:C27200 SNOMEDCT_US_2016_03_01:447785000 UMLS_CUI:C0744295 disease_ontology DOID:5280 gastric leiomyosarcoma DOID:5289 A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus. NCI:C6340 SNOMEDCT_US_2016_03_01:447389009 UMLS_CUI:C0280631 leiomyosarcoma of Corpus Uteri disease_ontology DOID:5289 uterus leiomyosarcoma DOID:5295 A gastrointestinal system disease that is located_in the intestine. DOID:10759 DOID:11222 DOID:11789 DOID:8531 DOID:8558 DOID:8591 ICD10CM:K63.9 ICD9CM:569.9 MESH:D007410 NCI:C26801 SNOMEDCT_US_2016_03_01:155629009 SNOMEDCT_US_2016_03_01:197266001 SNOMEDCT_US_2016_03_01:266483008 SNOMEDCT_US_2016_03_01:85919009 UMLS_CUI:C0021831 disease_ontology DOID:5295 intestinal disease DOID:53 An endocrine system disease that is located_in the pituitary gland. DOID:2445 DOID:8713 DOID:8714 ICD9CM:253.1 UMLS_CUI:C0029493 pituitary disease disease_ontology DOID:53 pituitary gland disease DOID:530 An adnexa disease that is located_in the eyelid. ICD10CM:H02.9 ICD9CM:374.9 MESH:D005141 NCI:C26768 SNOMEDCT_US_2016_03_01:155180006 SNOMEDCT_US_2016_03_01:193970000 SNOMEDCT_US_2016_03_01:267737009 SNOMEDCT_US_2016_03_01:60113004 UMLS_CUI:C0015423 disease_ontology DOID:530 eyelid disease DOID:5303 NCI:C6344 UMLS_CUI:C1332912 Clear cell carcinoma of the Cervix Uteri disease_ontology DOID:5303 cervical clear cell adenocarcinoma DOID:5304 NCI:C40078 UMLS_CUI:C1518693 disease_ontology DOID:5304 ovarian clear cell adenocarcinoma DOID:5309 NCI:C4199 SNOMEDCT_US_2016_03_01:189722008 SNOMEDCT_US_2016_03_01:9618003 UMLS_CUI:C0334392 disease_ontology DOID:5309 epithelial-myoepithelial carcinoma DOID:5327 ICD10CM:H33.2 ICD9CM:361.9 MESH:D012163 NCI:C26874 SNOMEDCT_US_2016_03_01:155103005 SNOMEDCT_US_2016_03_01:193347002 SNOMEDCT_US_2016_03_01:42059000 UMLS_CUI:C0035305 disease_ontology DOID:5327 retinal detachment DOID:533 DOID:11024 ICD10CM:E32 ICD10CM:E32.9 ICD9CM:254 ICD9CM:254.9 NCI:C26962 SNOMEDCT_US_2016_03_01:154703006 SNOMEDCT_US_2016_03_01:190500009 SNOMEDCT_US_2016_03_01:20673009 SNOMEDCT_US_2016_03_01:267482009 UMLS_CUI:C0154199 disease of thymus gland disease_ontology DOID:533 thymus gland disease DOID:5330 MESH:D003788 NCI:C34530 SNOMEDCT_US_2016_03_01:57203004 UMLS_CUI:C0011405 Dental pulp disorder disorder of pulp of tooth (disorder) pulp disorder disease_ontology DOID:5330 dental pulp disease DOID:5340 An amnestic disorder that involves the impaired or lost ability to memorize new things. ICD10CM:R41.1 MESH:D020324 SNOMEDCT_US_2016_03_01:206789002 SNOMEDCT_US_2016_03_01:88822006 UMLS_CUI:C0233795 disease_ontology DOID:5340 anterograde amnesia DOID:535 A disease of mental health that involves disruption of sleep patterns. DOID:9028 ICD9CM:307.4 UMLS_CUI:C0154564 Non-organic sleep disorder disease_ontology DOID:535 sleep disorder DOID:5353 DOID:10758 MESH:D003108 SNOMEDCT_US_2016_03_01:128524007 UMLS_CUI:C0009373 colon disorder disease_ontology DOID:5353 colonic disease DOID:5363 MESH:D018208 OMIM:613488 SNOMEDCT_US_2016_03_01:27849002 SNOMEDCT_US_2016_03_01:404069006 UMLS_CUI:C0206634 Myxoid Liposarcoma Myxoid liposarcoma (disorder) Myxoid liposarcoma (morphologic abnormality) disease_ontology DOID:5363 OMIM mapping confirmed by DO. [SN]. myxoid liposarcoma DOID:5386 NCI:C4455 SNOMEDCT_US_2016_03_01:254642004 UMLS_CUI:C0345964 adenoma of lung pulmonary adenoma disease_ontology DOID:5386 lung adenoma DOID:5389 MESH:D018249 NCI:C3759 SNOMEDCT_US_2016_03_01:89439007 UMLS_CUI:C1510502 Follicular adenoma, oxyphilic cell Oncocytoma disease_ontology DOID:5389 oxyphilic adenoma DOID:539 DOID:10868 ICD9CM:378.56 MESH:D009886 NCI:C79697 SNOMEDCT_US_2016_03_01:155196009 SNOMEDCT_US_2016_03_01:16110005 SNOMEDCT_US_2016_03_01:267745004 SNOMEDCT_US_2016_03_01:78097002 UMLS_CUI:C0029089 UMLS_CUI:C0155338 Total ophthalmoplegia oculomotor paralysis disease_ontology DOID:539 ophthalmoplegia DOID:5395 NCI:C8388 UMLS_CUI:C0854486 Secretory adenoma of the Pituitary gland disease_ontology DOID:5395 functioning pituitary adenoma DOID:540 ICD10CM:H50.8 ICD10CM:H50.89 ICD9CM:378.7 SNOMEDCT_US_2016_03_01:194125000 SNOMEDCT_US_2016_03_01:194128003 SNOMEDCT_US_2016_03_01:194651002 UMLS_CUI:C0029831 disease_ontology DOID:540 strabismus DOID:5403 MESH:D000236 NCI:C3685 SNOMEDCT_US_2016_03_01:189580001 SNOMEDCT_US_2016_03_01:79494009 UMLS_CUI:C0205648 Microcystic adenoma Microcystic adenoma (morphologic abnormality) disease_ontology DOID:5403 microcystic adenoma DOID:5408 A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs. EFO:0004261 ICD10CM:M88 MESH:D010001 NCI:C3292 OMIM:167250 OMIM:602080 OMIM:606263 ORDO:280110 SNOMEDCT_US_2016_03_01:156811005 SNOMEDCT_US_2016_03_01:156812003 SNOMEDCT_US_2016_03_01:203353000 SNOMEDCT_US_2016_03_01:203354006 SNOMEDCT_US_2016_03_01:2089002 UMLS_CUI:C0029401 Paget disease of bone Paget's bone disease osseous Paget's disease osteitis deformans disease_ontology Familial Paget's disease of bone DOID:5408 Xref MGI. MESH:C538098 added from NeuroDevNet [WAK]. Paget's disease of bone DOID:5409 A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells. KEGG:05222 MESH:D055752 NCI:C4917 OMIM:182280 SNOMEDCT_US_2016_03_01:254632001 SNOMEDCT_US_2016_03_01:254633006 UMLS_CUI:C0149925 Oat cell carcinoma of lung (disorder) SCLC small cell carcinoma of lung (disorder) small cell neuroendocrine carcinoma of lung disease_ontology small cell carcinoma of lung DOID:5409 OMIM mapping confirmed by DO. [SN]. lung small cell carcinoma DOID:5411 MESH:D018288 NCI:C3915 SNOMEDCT_US_2016_03_01:189555001 SNOMEDCT_US_2016_03_01:74364000 SNOMEDCT_US_2016_03_01:76817009 UMLS_CUI:C0262584 Oat cell carcinoma (morphologic abnormality) oat cell carcinoma poorly differentiated Endocrine neoplasm disease_ontology DOID:5411 lung oat cell carcinoma DOID:5418 A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality. ICD10CM:F25 ICD10CM:F25.9 ICD9CM:295.7 MESH:D011618 NCI:C94378 SNOMEDCT_US_2016_03_01:191567000 SNOMEDCT_US_2016_03_01:191568005 SNOMEDCT_US_2016_03_01:191575006 SNOMEDCT_US_2016_03_01:192345003 SNOMEDCT_US_2016_03_01:231490005 SNOMEDCT_US_2016_03_01:68890003 UMLS_CUI:C0036337 disease_ontology DOID:5418 schizoaffective disorder DOID:5419 A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. DOID:14734 EFO:0000692 HP:0100753 ICD9CM:295.8 ICD9CM:295.80 MESH:D012559 OMIM:181500 OMIM:181510 OMIM:600511 OMIM:600850 OMIM:603013 OMIM:603175 OMIM:603176 OMIM:603206 OMIM:603342 OMIM:604906 OMIM:605419 OMIM:608078 OMIM:608543 OMIM:612361 OMIM:613025 OMIM:613950 OMIM:613959 OMIM:615232 UMLS_CUI:C0029838 UMLS_CUI:C0220702 schizophrenia-1 disease_ontology DOID:5419 Xref MGI. OMIM mapping confirmed by DO. [SN]. schizophrenia DOID:5425 MESH:D016471 OMIM:608115 SNOMEDCT_US_2016_03_01:129635004 UMLS_CUI:C0085083 secondary Meig's syndrome disease_ontology DOID:5425 OMIM mapping confirmed by DO. [SN]. ovarian hyperstimulation syndrome DOID:5426 An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40. ICD10CM:E28.3 MESH:D016649 NCI:C113352 OMIM:300510 OMIM:300511 OMIM:300604 OMIM:311360 OMIM:608996 OMIM:611548 OMIM:612310 OMIM:612964 OMIM:615723 OMIM:615724 ORDO:619 SNOMEDCT_US_2016_03_01:190545008 SNOMEDCT_US_2016_03_01:237788002 SNOMEDCT_US_2016_03_01:39381003 SNOMEDCT_US_2016_03_01:65846009 UMLS_CUI:C0085215 hypergonadotropic hypogonadism premature menopause premature ovarian insufficiency primary ovarian insufficiency disease_ontology DOID:5426 Xref MGI. OMIM mapping confirmed by DO. [SN]. premature ovarian failure DOID:543 DOID:544 ICD10CM:G24 ICD10CM:G24.9 MESH:D004421 MESH:D020821 NCI:C34563 SNOMEDCT_US_2016_03_01:15802004 SNOMEDCT_US_2016_03_01:192863009 SNOMEDCT_US_2016_03_01:194478005 SNOMEDCT_US_2016_03_01:250068003 UMLS_CUI:C0013421 UMLS_CUI:C0393593 dystonic disease disease_ontology DOID:543 dystonia DOID:5432 NCI:C39857 UMLS_CUI:C1511197 urinary bladder Papillary Urothelial neoplasm disease_ontology DOID:5432 bladder papillary transitional cell neoplasm DOID:5433 DOID:6120 NCI:C27883 NCI:C6192 UMLS_CUI:C1334282 UMLS_CUI:C1335329 Inverted papilloma of urinary tract Papillary transitional cell neoplasm of the urinary tract urinary tract inverted papilloma disease_ontology DOID:5433 urinary tract papillary transitional cell benign neoplasm DOID:5434 MESH:D012608 SNOMEDCT_US_2016_03_01:35103004 UMLS_CUI:C0036457 disease_ontology DOID:5434 scrapie DOID:5453 MESH:D011668 NCI:C85039 OMIM:265450 SNOMEDCT_US_2016_03_01:89420002 UMLS_CUI:C0034091 pulmonary veno-occlusive disease (disorder) disease_ontology DOID:5453 OMIM mapping confirmed by DO. [SN]. pulmonary venoocclusive disease DOID:5485 A synovium cancer which develops in the synovial membrane of the joints. MESH:D013584 NCI:C3400 OMIM:300813 SNOMEDCT_US_2016_03_01:302851001 SNOMEDCT_US_2016_03_01:63211008 UMLS_CUI:C0039101 disease_ontology DOID:5485 Xref MGI. synovial sarcoma DOID:5502 A parasitic ectoparasitic infectious disease that involves infestation of lice, which are blood-feeding ectoparasitic insects of the order Phthiraptera. DOID:5490 DOID:5523 ICD10CM:B85.2 ICD9CM:132.9 MESH:D010373 SNOMEDCT_US_2016_03_01:154417001 SNOMEDCT_US_2016_03_01:187207005 SNOMEDCT_US_2016_03_01:187212006 SNOMEDCT_US_2016_03_01:187545007 SNOMEDCT_US_2016_03_01:20848007 SNOMEDCT_US_2016_03_01:266223008 SNOMEDCT_US_2016_03_01:414618002 SNOMEDCT_US_2016_03_01:74949007 UMLS_CUI:C0030756 Infestation by Pediculus (disorder) Lice infestation, NOS Louse infestation (& [pediculosis and phthirus] or [lice]) Louse infestation (disorder) Pediculosis + lice NOS Pediculosis and phthirus infection NOS (disorder) Pediculosis and phthirus infections (disorder) Pediculosis and phthirus infestation Pediculosis, unspecified Pediculosis, unspecified (disorder) mixed pediculosis mixed pediculosis (disorder) mixed pediculosis infestation pediculosis pediculosis and phthirus infection disease_ontology DOID:5502 lice infestation DOID:5514 DOID:7300 NCI:C5177 UMLS_CUI:C1336079 SCC of breast breast primary squamous cell carcinoma primary squamous cell carcinoma of the breast disease_ontology primary squamous cell carcinoma of breast squamous cell carcinoma of breast DOID:5514 breast squamous cell carcinoma DOID:5515 A nasal cavity carcinoma that has_material_basis_in squamous cells. NCI:C8192 UMLS_CUI:C0280333 squamous cell carcinoma of the nasal cavity disease_ontology squamous cell carcinoma of nasal cavity DOID:5515 nasal cavity squamous cell carcinoma DOID:5516 NCI:C5475 UMLS_CUI:C1333789 squamous cell carcinoma of stomach disease_ontology DOID:5516 gastric squamous cell carcinoma DOID:5517 A stomach cancer that is located_in the stomach. EFO:0000178 NCI:C4911 SNOMEDCT_US_2016_03_01:154446008 SNOMEDCT_US_2016_03_01:255080008 SNOMEDCT_US_2016_03_01:372143007 UMLS_CUI:C0699791 cancer of the stomach carcinoma of stomach carcinoma of stomach (disorder) gastric carcinoma disease_ontology DOID:5517 stomach carcinoma DOID:552 A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. DOID:10509 DOID:11742 DOID:5871 MESH:D011014 NCI:C3333 SNOMEDCT_US_2016_03_01:155548002 SNOMEDCT_US_2016_03_01:155552002 SNOMEDCT_US_2016_03_01:155558003 SNOMEDCT_US_2016_03_01:233604007 SNOMEDCT_US_2016_03_01:266391003 SNOMEDCT_US_2016_03_01:274103002 SNOMEDCT_US_2016_03_01:60363000 UMLS_CUI:C0032285 acute pneumonia disease_ontology DOID:552 pneumonia DOID:5520 A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck. MESH:C535575 NCI:C34447 OMIM:275355 UMLS_CUI:C1168401 carcinoma of the head and neck squamous cell carcinoma of the head and neck squamous cell carcinomas of head and neck disease_ontology DOID:5520 OMIM mapping confirmed by DO. [SN]. head and neck squamous cell carcinoma DOID:5533 NCI:C8719 UMLS_CUI:C1333396 squamous cell carcinoma of Endometrium disease_ontology DOID:5533 endometrial squamous cell carcinoma DOID:5557 A testicular cancer that has_material_basis_in germ cells. MESH:C563236 NCI:C8591 OMIM:273300 OMIM:300228 ORDO:3636504 SNOMEDCT_US_2016_03_01:713577007 UMLS_CUI:C1336708 germ cell tumor of testis disease_ontology testicular germ cell neoplasm DOID:5557 Xref MGI. OMIM mapping confirmed by DO. [LS]. testicular germ cell cancer DOID:5559 A thoracic cancer that is located_in the mediastinum. DOID:9914 ICD10CM:C38.3 ICD9CM:164.9 MESH:D008479 NCI:C3221 NCI:C3549 SNOMEDCT_US_2016_03_01:126725000 SNOMEDCT_US_2016_03_01:187889002 SNOMEDCT_US_2016_03_01:190097009 SNOMEDCT_US_2016_03_01:363494000 SNOMEDCT_US_2016_03_01:93891008 SNOMEDCT_US_2016_03_01:94147001 UMLS_CUI:C0025063 UMLS_CUI:C0153504 Tumour of mediastinum mediastinal tumor mediastinum cancer neoplasm of mediastinum (disorder) disease_ontology DOID:5559 mediastinal cancer DOID:5568 NCI:C6438 UMLS_CUI:C1334682 teratoma of mediastinum disease_ontology DOID:5568 mediastinum teratoma DOID:557 A urinary system disease that is located_in the kidney. EFO:0003086 ICD10CM:N08 ICD10CM:N28.9 MESH:D007674 NCI:C3149 NCI:C34843 SNOMEDCT_US_2016_03_01:155871008 SNOMEDCT_US_2016_03_01:266612003 SNOMEDCT_US_2016_03_01:266624005 SNOMEDCT_US_2016_03_01:266627003 SNOMEDCT_US_2016_03_01:274108006 SNOMEDCT_US_2016_03_01:90708001 UMLS_CUI:C0022658 nephropathy disease_ontology DOID:557 kidney disease DOID:5572 A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations. ICD10CM:Q87.3 MESH:D001506 NCI:C34415 OMIM:130650 ORDO:116 SNOMEDCT_US_2016_03_01:81780002 UMLS_CUI:C0004903 disease_ontology DOID:5572 OMIM mapping confirmed by DO. [SN]. Beckwith-Wiedemann syndrome DOID:5583 A lung carcinoma that is located_in large undifferentiated cells. DOID:5584 MESH:D018286 NCI:C3779 NCI:C4452 SNOMEDCT_US_2016_03_01:254631008 SNOMEDCT_US_2016_03_01:42596004 UMLS_CUI:C0206703 UMLS_CUI:C0345960 Giant cell carcinoma Giant cell lung carcinoma disease_ontology DOID:5583 lung giant cell carcinoma DOID:5588 NCI:C5650 UMLS_CUI:C1335325 Papillary adenocarcinoma of the lung disease_ontology DOID:5588 lung papillary adenocarcinoma DOID:5600 A lymphoblastic leukemia that has_material_basis_in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located_in bone marrow and located_in peripheral blood. MESH:D054198 NCI:C7055 UMLS_CUI:C1335469 disease_ontology DOID:5600 precursor lymphoblastic lymphoma/leukemia DOID:5603 CSP:2004-1600 CSP:2004-1803 ICD10CM:C91.5 ICD10CM:C91.50 MESH:D015459 NCI:C3184 SNOMEDCT_US_2016_03_01:110007008 SNOMEDCT_US_2016_03_01:188729005 SNOMEDCT_US_2016_03_01:77430005 UMLS_CUI:C0023493 Precursor T Lymphoblastic Leukemia T-cell acute lymphoblastic leukemia (disorder) disease_ontology DOID:5603 acute T cell leukemia DOID:5604 NCI:C4967 UMLS_CUI:C0751606 adult acute lymphoid Leukemia disease_ontology DOID:5604 adult acute lymphocytic leukemia DOID:5605 NCI:C9119 UMLS_CUI:C0860580 Medullary breast carcinoma with lymphoid Stroma disease_ontology medullary carcinoma of breast DOID:5605 breast medullary carcinoma DOID:561 ICD9CM:350.8 UMLS_CUI:C0029834 disease_ontology DOID:561 trigeminal nerve disease DOID:5614 An eye and adnexa disease that is located_in the eye. DOID:2933 ICD10CM:H44 ICD10CM:H44.9 ICD9CM:360 ICD9CM:360.9 ICD9CM:379.90 MESH:D005128 NCI:C26767 SNOMEDCT_US_2016_03_01:111509007 SNOMEDCT_US_2016_03_01:155101007 SNOMEDCT_US_2016_03_01:155198005 SNOMEDCT_US_2016_03_01:193265001 SNOMEDCT_US_2016_03_01:193266000 SNOMEDCT_US_2016_03_01:193316008 SNOMEDCT_US_2016_03_01:194183009 SNOMEDCT_US_2016_03_01:264555006 SNOMEDCT_US_2016_03_01:366261005 SNOMEDCT_US_2016_03_01:371405004 SNOMEDCT_US_2016_03_01:371409005 SNOMEDCT_US_2016_03_01:79517001 UMLS_CUI:C0015397 disease_ontology DOID:5614 eye disease DOID:5635 NCI:C5474 UMLS_CUI:C1333761 Adenosquamous carcinoma of stomach disease_ontology DOID:5635 gastric adenosquamous carcinoma DOID:5637 A pancreatic ductal carcinoma that derives_from squamous cells and gland-like cells. NCI:C5721 UMLS_CUI:C1335299 Adenosquamous carcinoma of pancreas disease_ontology adenosquamous carcinoma of the pancreas DOID:5637 adenosquamous pancreas carcinoma DOID:5648 A choroid plexus cancer that has_material_basis_in epithelial cells of the choroid plexus. DOID:5647 MESH:C562943 NCI:C4533 NCI:C4715 SNOMEDCT_US_2016_03_01:188292007 SNOMEDCT_US_2016_03_01:88252006 UMLS_CUI:C0346289 UMLS_CUI:C0431109 Choroid plexus carcinoma (morphologic abnormality) cancer of Choroid Plexus malignant neoplasm of choroid plexus malignant neoplasm of the Choroid Plexus malignant tumor of choroid plexus (disorder) disease_ontology malignant tumor of choroid plexus DOID:5648 choroid plexus carcinoma DOID:5656 A neuropathy that is located_in one of the twelve cranial nerves. ICD10CM:G52.9 ICD9CM:352.9 MESH:D003389 NCI:C26733 SNOMEDCT_US_2016_03_01:193104009 SNOMEDCT_US_2016_03_01:267598004 SNOMEDCT_US_2016_03_01:267709002 SNOMEDCT_US_2016_03_01:276379008 SNOMEDCT_US_2016_03_01:73013002 UMLS_CUI:C0010266 Cranial nerve disorder disorder of cranial nerve disease_ontology DOID:5656 cranial nerve disease DOID:5667 NCI:C6938 SNOMEDCT_US_2016_03_01:254707006 SNOMEDCT_US_2016_03_01:254708001 SNOMEDCT_US_2016_03_01:32272007 UMLS_CUI:C1412016 carcinoma of the Sweat gland disease_ontology DOID:5667 sweat gland carcinoma DOID:5670 A carcinoma that is in situ. NCI:C4188 SNOMEDCT_US_2016_03_01:189709000 SNOMEDCT_US_2016_03_01:36425007 UMLS_CUI:C0334370 Comedocarcinoma disease_ontology DOID:5670 comedo carcinoma DOID:5672 An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other. DOID:1994 DOID:1997 ICD10CM:C18.9 MESH:D015179 NCI:C2955 NCI:C4978 NCI:C5105 SNOMEDCT_US_2016_03_01:363510005 SNOMEDCT_US_2016_03_01:408645001 SNOMEDCT_US_2016_03_01:93854002 UMLS_CUI:C0009402 UMLS_CUI:C0346629 UMLS_CUI:C1319315 disease_ontology DOID:5672 large intestine cancer DOID:5679 An eye disease that is located_in the retina. ICD10CM:H35.9 ICD9CM:362.9 MESH:D012164 NCI:C26875 NCI:C62601 SNOMEDCT_US_2016_03_01:193430004 SNOMEDCT_US_2016_03_01:267715002 SNOMEDCT_US_2016_03_01:29555009 SNOMEDCT_US_2016_03_01:35426003 SNOMEDCT_US_2016_03_01:399625000 UMLS_CUI:C0035309 disease_ontology DOID:5679 retinal disease DOID:5688 An autosomal recessive disease characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers. In 90% of the cases it is that has material basis in mutations in the WRN gene, on chromosome 8. MESH:D014898 NCI:C3447 OMIM:277700 ORDO:902 SNOMEDCT_US_2016_03_01:190590004 SNOMEDCT_US_2016_03_01:190592007 SNOMEDCT_US_2016_03_01:51626007 UMLS_CUI:C0043119 WS Werner's syndrome adult premature ageing syndrome adult progeria disease_ontology DOID:5688 OMIM mapping confirmed by DO. [LS]. Werner syndrome DOID:57 An aortic valve disease that is characterized by leaking of the aortic valve of the heart causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. DOID:54 DOID:55 ICD10CM:I06.1 ICD9CM:395.1 ICD9CM:396.3 MESH:D001022 NCI:C50861 NCI:C51223 SNOMEDCT_US_2016_03_01:155283004 SNOMEDCT_US_2016_03_01:194736003 SNOMEDCT_US_2016_03_01:60234000 SNOMEDCT_US_2016_03_01:78031003 UMLS_CUI:C0003504 UMLS_CUI:C0155568 UMLS_CUI:C0264774 Rheumatic aortic insufficiency Rheumatic aortic regurgitation Rheumatic aortic valve regurgitation aortic incompetence aortic insufficiency aortic regurgitation rheumatic aortic valve insufficiency disease_ontology Corrigan's disease DOID:57 aortic valve insufficiency DOID:571 ICD10CM:G56.1 ICD10CM:G56.10 ICD9CM:354.1 SNOMEDCT_US_2016_03_01:193127001 SNOMEDCT_US_2016_03_01:194512000 UMLS_CUI:C0154742 disease_ontology DOID:571 median neuropathy DOID:5716 DOID:6254 NCI:C7047 NCI:C7911 UMLS_CUI:C0278864 UMLS_CUI:C0851693 Pituitary tumors, Hormone Producing Somatotropinoma growth hormone producing pituitary tumor disease_ontology DOID:5716 hormone producing pituitary cancer DOID:5718 An adrenal gland cancer that derives_from immature neuroblastic cells. NCI:C4827 SNOMEDCT_US_2016_03_01:281562007 UMLS_CUI:C0559460 neuroblastoma of Adrenal gland disease_ontology DOID:5718 adrenal neuroblastoma DOID:5719 An adrenal gland cancer that is located_in the adrenal medulla. DOID:662 ICD10CM:C74.1 NCI:C4396 NCI:C4856 SNOMEDCT_US_2016_03_01:127023007 SNOMEDCT_US_2016_03_01:363480001 SNOMEDCT_US_2016_03_01:371965009 SNOMEDCT_US_2016_03_01:93666006 UMLS_CUI:C0344456 UMLS_CUI:C0596046 adrenal medulla neoplasm adrenal medulla tumor malignant neoplasm of adrenal medulla malignant tumor of the Adrenal Medulla disease_ontology DOID:5719 adrenal medulla cancer DOID:572 ICD9CM:354 SNOMEDCT_US_2016_03_01:155072002 SNOMEDCT_US_2016_03_01:193125009 UMLS_CUI:C0154741 disease_ontology DOID:572 mononeuritis of upper limb and mononeuritis multiplex DOID:5723 ICD10CM:H47.2 ICD10CM:H47.20 ICD9CM:377.1 ICD9CM:377.10 MESH:D009896 NCI:C34863 OMIM:165300 OMIM:165500 OMIM:258500 OMIM:311050 OMIM:605293 OMIM:610708 ORDO:98673 SNOMEDCT_US_2016_03_01:155188004 SNOMEDCT_US_2016_03_01:194042009 SNOMEDCT_US_2016_03_01:194046007 SNOMEDCT_US_2016_03_01:267742001 SNOMEDCT_US_2016_03_01:76976005 UMLS_CUI:C0029124 atrophy of optic disc disease_ontology DOID:5723 Xref MGI. optic atrophy DOID:5731 ICD10CM:N70.11 NCI:C40118 SNOMEDCT_US_2016_03_01:55551005 UMLS_CUI:C0269041 disease_ontology DOID:5731 chronic salpingitis DOID:5733 ICD10CM:N70.91 MESH:D012488 NCI:C26880 SNOMEDCT_US_2016_03_01:155968004 SNOMEDCT_US_2016_03_01:198151009 SNOMEDCT_US_2016_03_01:266648001 SNOMEDCT_US_2016_03_01:88157006 UMLS_CUI:C0036130 disease_ontology DOID:5733 salpingitis DOID:574 A nervous system disease that affects the peripheral nervous system. DOID:13069 ICD10CM:G64 ICD9CM:350-359.99 MESH:D010523 NCI:C119734 NCI:C27580 NCI:C27587 SNOMEDCT_US_2016_03_01:155064004 SNOMEDCT_US_2016_03_01:155080009 SNOMEDCT_US_2016_03_01:155100008 SNOMEDCT_US_2016_03_01:193088006 SNOMEDCT_US_2016_03_01:193264002 SNOMEDCT_US_2016_03_01:264554005 SNOMEDCT_US_2016_03_01:267706009 SNOMEDCT_US_2016_03_01:302226006 SNOMEDCT_US_2016_03_01:42658009 UMLS_CUI:C0031117 UMLS_CUI:C1335029 disease_ontology peripheral nerve disease peripheral neuropathy DOID:574 peripheral nervous system disease DOID:576 ICD10CM:R80 ICD10CM:R80.9 ICD9CM:791.0 MESH:D011507 NCI:C38012 SNOMEDCT_US_2016_03_01:144515004 SNOMEDCT_US_2016_03_01:158565005 SNOMEDCT_US_2016_03_01:158568007 SNOMEDCT_US_2016_03_01:167279003 SNOMEDCT_US_2016_03_01:207310001 SNOMEDCT_US_2016_03_01:207315006 SNOMEDCT_US_2016_03_01:232691000 SNOMEDCT_US_2016_03_01:236719005 SNOMEDCT_US_2016_03_01:29738008 UMLS_CUI:C0033687 disease_ontology DOID:576 proteinuria DOID:5768 An acrofacial dysostosis characterized by underdeveloped cheek bones, very small lower jaw, cleft palate, defects in the middle ear, absent eyelashes, and a notch in the lower eyelids called a coloboma, in children. NCI:C35795 OMIM:154400 UMLS_CUI:C1332140 AFD Nager syndrome acrofacial dysostosis 1, Nager type preaxial acrofacial dysostosis preaxial manibulofacial dysostosis disease_ontology DOID:5768 OMIM mapping confirmed by DO. [SN]. Nager acrofacial dysostosis DOID:5782 ICD10CM:H73.9 ICD10CM:H73.90 ICD9CM:384.9 SNOMEDCT_US_2016_03_01:194326008 SNOMEDCT_US_2016_03_01:21426000 UMLS_CUI:C0041825 disease_ontology DOID:5782 tympanic membrane disease DOID:580 ICD9CM:274.11 NCI:C123037 NCI:C123245 SNOMEDCT_US_2016_03_01:16410004 SNOMEDCT_US_2016_03_01:190831009 SNOMEDCT_US_2016_03_01:197793002 SNOMEDCT_US_2016_03_01:267441009 UMLS_CUI:C0403719 Uric acid nephrolithiasis Uric acid urolithiasis disease_ontology DOID:580 acute urate nephropathy DOID:5810 A severe combined immunodeficiency that is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines. Lack of ADA causes accumulation of dATP. CSP:1560-6660 ICD10CM:D81.3 NCI:C3962 OMIM:102700 SNOMEDCT_US_2016_03_01:124523006 SNOMEDCT_US_2016_03_01:190738006 SNOMEDCT_US_2016_03_01:190999009 SNOMEDCT_US_2016_03_01:44940001 UMLS_CUI:C0268124 ADA disease_ontology DOID:5810 adenosine deaminase deficiency DOID:5813 A combined T cell and B cell immunodeficiency that is a rare autosomal recessive metabolic disorder that has material basis in mutation in the PNP gene and characterized mainly by decreased T-cell function. ICD10CM:D81.5 MESH:C562587 NCI:C3963 OMIM:613179 SNOMEDCT_US_2016_03_01:124271005 SNOMEDCT_US_2016_03_01:191000008 SNOMEDCT_US_2016_03_01:60743005 UMLS_CUI:C0268125 PNP deficiency Purine nucleoside phosphorylase deficiency Purine-Nucleoside Phosphorylase deficiency deficiency of inosine phosphorylase disease_ontology DOID:5813 OMIM mapping confirmed by DO. [SN]. purine nucleoside phosphorylase deficiency DOID:5822 A lymphoma that is characterized by having cellular features of both classic Hodgkin's lymphomas and large B-cell Lymphomas. NCI:C37869 UMLS_CUI:C1333878 disease_ontology DOID:5822 gray zone lymphoma DOID:5823 NCI:C5165 UMLS_CUI:C1332979 disease_ontology DOID:5823 pediatric lymphoma DOID:5828 NCI:C7979 SNOMEDCT_US_2016_03_01:254852002 UMLS_CUI:C0346163 Ovarian endometrioid carcinoma endometrioid carcinoma ovary (disorder) disease_ontology endometrioid carcinoma of ovary DOID:5828 endometrioid ovary carcinoma DOID:583 ICD10CM:D55-D59 MESH:D000743 NCI:C34376 OMIM:266120 OMIM:612631 SNOMEDCT_US_2016_03_01:191231008 SNOMEDCT_US_2016_03_01:191416001 SNOMEDCT_US_2016_03_01:61261009 UMLS_CUI:C0002878 ANEMIA HEMOLYTIC disease_ontology DOID:583 OMIM mapping confirmed by DO. [SN]. OMIM mapping by NeuroDevNet. [LS]. hemolytic anemia DOID:5844 A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia. EFO:0000612 ICD10CM:I21 ICD10CM:I22 MESH:D009203 NCI:C27996 OMIM:608446 OMIM:608557 SNOMEDCT_US_2016_03_01:155304006 SNOMEDCT_US_2016_03_01:194796000 SNOMEDCT_US_2016_03_01:22298006 SNOMEDCT_US_2016_03_01:233824008 SNOMEDCT_US_2016_03_01:266288001 SNOMEDCT_US_2016_03_01:66514008 UMLS_CUI:C0027051 Myocardial infarct heart attack disease_ontology DOID:5844 Xref MGI. myocardial infarction DOID:585 EFO:0004253 ICD10CM:N20 ICD10CM:N20.2 ICD9CM:592 OMIM:167030 SNOMEDCT_US_2016_03_01:155867005 SNOMEDCT_US_2016_03_01:197792007 SNOMEDCT_US_2016_03_01:197796005 SNOMEDCT_US_2016_03_01:266556005 SNOMEDCT_US_2016_03_01:266622009 UMLS_CUI:C0156257 NEPHROLITHIASIS, CALCIUM OXALATE Stone - kidney/ureter UROLITHIASIS, CALCIUM OXALATE calculus of kidney and ureter kidney stones disease_ontology DOID:585 OMIM mapping confirmed by DO. [SN]. nephrolithiasis DOID:589 ICD10CM:D58.9 ICD9CM:282 ICD9CM:282.9 MESH:D000745 NCI:C34379 SNOMEDCT_US_2016_03_01:154794008 SNOMEDCT_US_2016_03_01:154801000 SNOMEDCT_US_2016_03_01:191208008 SNOMEDCT_US_2016_03_01:267556002 SNOMEDCT_US_2016_03_01:267558001 SNOMEDCT_US_2016_03_01:38911009 SNOMEDCT_US_2016_03_01:42601008 UMLS_CUI:C0002881 hereditary hemolytic anemia disease_ontology DOID:589 congenital hemolytic anemia DOID:591 An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation. ICD10CM:F40 ICD10CM:F40.9 ICD9CM:300.2 ICD9CM:300.20 MESH:D010698 NCI:C35420 SNOMEDCT_US_2016_03_01:154884005 SNOMEDCT_US_2016_03_01:191720001 SNOMEDCT_US_2016_03_01:191721002 SNOMEDCT_US_2016_03_01:191734001 SNOMEDCT_US_2016_03_01:192393009 SNOMEDCT_US_2016_03_01:192398000 SNOMEDCT_US_2016_03_01:268630000 SNOMEDCT_US_2016_03_01:386808001 SNOMEDCT_US_2016_03_01:386810004 SNOMEDCT_US_2016_03_01:52039009 SNOMEDCT_US_2016_03_01:65673007 UMLS_CUI:C0349231 disease_ontology DOID:591 phobic disorder DOID:593 A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable. ICD10CM:F40.0 ICD10CM:F40.00 MESH:D000379 NCI:C34362 SNOMEDCT_US_2016_03_01:154885006 SNOMEDCT_US_2016_03_01:192394003 SNOMEDCT_US_2016_03_01:247830007 SNOMEDCT_US_2016_03_01:70691001 UMLS_CUI:C0001818 Fear of open spaces (finding) disease_ontology DOID:593 agoraphobia DOID:594 An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress. EFO:0004262 MESH:D016584 NCI:C34890 OMIM:167870 OMIM:607853 OMIM:609985 SNOMEDCT_US_2016_03_01:191705007 SNOMEDCT_US_2016_03_01:192400001 SNOMEDCT_US_2016_03_01:268627007 SNOMEDCT_US_2016_03_01:371631005 UMLS_CUI:C0030319 panic anxiety syndrome disease_ontology DOID:594 Xref MGI. panic disorder DOID:5974 NCI:C7355 UMLS_CUI:C0238410 Urothelial cell carcinoma of renal Pelvis disease_ontology DOID:5974 renal pelvis transitional cell carcinoma DOID:6000 A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. DOID:395 ICD10CM:I50 ICD10CM:I50.9 ICD9CM:428 ICD9CM:428.0 ICD9CM:428.9 MESH:D006333 NCI:C3080 NCI:C50577 SNOMEDCT_US_2016_03_01:155374007 SNOMEDCT_US_2016_03_01:155375008 SNOMEDCT_US_2016_03_01:155377000 SNOMEDCT_US_2016_03_01:195108009 SNOMEDCT_US_2016_03_01:195117009 SNOMEDCT_US_2016_03_01:266248006 SNOMEDCT_US_2016_03_01:266308000 SNOMEDCT_US_2016_03_01:42343007 SNOMEDCT_US_2016_03_01:84114007 UMLS_CUI:C0018801 UMLS_CUI:C0018802 CHF Cardiac Failure Congestive Congestive heart disease Weak heart disease_ontology DOID:6000 congestive heart failure DOID:6050 A gastrointestinal system disease that is located_in the esophagus. DOID:10117 DOID:10118 DOID:11798 ICD10CM:K22.9 ICD9CM:530 ICD9CM:530.9 MESH:D004935 NCI:C3027 SNOMEDCT_US_2016_03_01:155671005 SNOMEDCT_US_2016_03_01:155680005 SNOMEDCT_US_2016_03_01:196626000 SNOMEDCT_US_2016_03_01:266497000 SNOMEDCT_US_2016_03_01:37657006 UMLS_CUI:C0014852 esophageal Ulcer disease_ontology DOID:6050 esophageal disease DOID:6088 An anxiety disorder that has_symptom flashbacks, has_symptom bad dreams, has_symptom frightening thoughts, has_symptom avoidance or has_symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD. ICD9CM:308.3 SNOMEDCT_US_2016_03_01:192040000 SNOMEDCT_US_2016_03_01:192043003 UMLS_CUI:C0029488 traumatic stress disorder disease_ontology DOID:6088 acute stress disorder DOID:61 DOID:11505 DOID:58 DOID:59 ICD10CM:I05 ICD10CM:I05.1 ICD10CM:I05.9 ICD9CM:394 ICD9CM:394.1 ICD9CM:424.0 NCI:C78446 SNOMEDCT_US_2016_03_01:11851006 SNOMEDCT_US_2016_03_01:155276006 SNOMEDCT_US_2016_03_01:155278007 SNOMEDCT_US_2016_03_01:155279004 SNOMEDCT_US_2016_03_01:194724009 SNOMEDCT_US_2016_03_01:194729004 SNOMEDCT_US_2016_03_01:194982000 SNOMEDCT_US_2016_03_01:250998008 SNOMEDCT_US_2016_03_01:266278002 SNOMEDCT_US_2016_03_01:266279005 SNOMEDCT_US_2016_03_01:31085000 SNOMEDCT_US_2016_03_01:83898004 UMLS_CUI:C0026265 UMLS_CUI:C0155563 UMLS_CUI:C0264765 Mitral RH valve dis. Rheumatic disease of mitral valve (disorder) Rheumatic mitral insufficiency Rheumatic mitral valve changes Rheumatic mitral valve regurgitation chronic rheumatic mitral valve (disorder) disease of mitral valve rheumatic disease of mitral valve rheumatic mitral valve incompetence disease_ontology DOID:61 mitral valve disease DOID:612 An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation. ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C3131 NCI:C39725 OMIM:242850 SNOMEDCT_US_2016_03_01:191005003 SNOMEDCT_US_2016_03_01:234532001 SNOMEDCT_US_2016_03_01:64431000 UMLS_CUI:C0021051 hypoimmunity immune deficiency disorder immunodeficiency syndrome disease_ontology DOID:612 Xref MGI. primary immunodeficiency disease DOID:6132 A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness. DOID:13503 DOID:13504 DOID:13707 DOID:13728 DOID:13729 DOID:5049 DOID:6130 DOID:6131 DOID:9982 DOID:9983 CSP:2596-1500 ICD10CM:J20 ICD10CM:J20.9 ICD10CM:J40 ICD10CM:J42 ICD9CM:466.0 ICD9CM:490 ICD9CM:491 ICD9CM:491.9 MESH:D001991 MESH:D029481 NCI:C26722 NCI:C26932 NCI:C2911 SNOMEDCT_US_2016_03_01:10509002 SNOMEDCT_US_2016_03_01:155512004 SNOMEDCT_US_2016_03_01:155515002 SNOMEDCT_US_2016_03_01:155566007 SNOMEDCT_US_2016_03_01:155572007 SNOMEDCT_US_2016_03_01:155616009 SNOMEDCT_US_2016_03_01:195713004 SNOMEDCT_US_2016_03_01:195733000 SNOMEDCT_US_2016_03_01:195936003 SNOMEDCT_US_2016_03_01:195940007 SNOMEDCT_US_2016_03_01:195956002 SNOMEDCT_US_2016_03_01:266354009 SNOMEDCT_US_2016_03_01:266380005 SNOMEDCT_US_2016_03_01:266395007 SNOMEDCT_US_2016_03_01:32398004 SNOMEDCT_US_2016_03_01:35301006 SNOMEDCT_US_2016_03_01:63480004 UMLS_CUI:C0006277 UMLS_CUI:C0008677 UMLS_CUI:C0149514 CI - Chest infection Chest infection acute Bronchitis chest cold chronic bronchitis recurrent wheezy bronchitis disease_ontology acute bronchitis and bronchiolitis DOID:6132 bronchitis DOID:614 A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood. ICD10CM:D72.810 ICD9CM:288.51 MESH:D008231 SNOMEDCT_US_2016_03_01:48813009 UMLS_CUI:C0024312 Lymphocytopenia disease_ontology DOID:614 lymphopenia DOID:615 A leukocyte disorder that is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection. ICD10CM:D72.819 ICD9CM:288.50 MESH:D007970 SNOMEDCT_US_2016_03_01:142917003 SNOMEDCT_US_2016_03_01:191348003 SNOMEDCT_US_2016_03_01:84828003 UMLS_CUI:C0023530 Leucopenia disease_ontology DOID:615 leukopenia DOID:6179 NCI:C27390 disease_ontology DOID:6179 ovarian small cell carcinoma DOID:6193 MESH:D012509 NCI:C3714 SNOMEDCT_US_2016_03_01:59238007 UMLS_CUI:C0205944 epithelioid cell sarcoma epithelioid sarcoma (morphologic abnormality) disease_ontology DOID:6193 epithelioid sarcoma DOID:6195 A conjunctival disease characterized by an inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids. ICD10CM:H10 ICD10CM:H10.9 ICD9CM:372.30 MESH:D003231 NCI:C34504 SNOMEDCT_US_2016_03_01:193857008 SNOMEDCT_US_2016_03_01:193858003 SNOMEDCT_US_2016_03_01:193875009 SNOMEDCT_US_2016_03_01:9826008 UMLS_CUI:C0009763 disease_ontology Madras eye DOID:6195 conjunctivitis DOID:62 DOID:56 ICD9CM:395 ICD9CM:424.1 MESH:C563178 NCI:C78650 SNOMEDCT_US_2016_03_01:194988001 SNOMEDCT_US_2016_03_01:8722008 UMLS_CUI:C1260873 disease_ontology DOID:62 Updating out dated UMLS CUI. aortic valve disease DOID:6204 MESH:D000236 SNOMEDCT_US_2016_03_01:55021007 UMLS_CUI:C0205647 Follicular adenoma (morphologic abnormality) Follicular adenoma of the Thyroid gland Thyroid follicular adenoma (disorder) disease_ontology DOID:6204 follicular adenoma DOID:6217 DOID:4946 NCI:C4127 NCI:C9159 SNOMEDCT_US_2016_03_01:24505004 UMLS_CUI:C0279635 UMLS_CUI:C0334280 Diffuse type adenocarcinoma adenocarcinoma of Linitis Plastica type carcinoma, diffuse type (morphologic abnormality) diffuse type carcinoma disease_ontology DOID:6217 gastric diffuse adenocarcinoma DOID:6225 NCI:C7035 UMLS_CUI:C1333764 gastric Cronkhite Canada polyposis disease_ontology DOID:6225 Cronkhite-Canada syndrome DOID:6239 DOID:6238 NCI:C27884 NCI:C39831 SNOMEDCT_US_2016_03_01:128625004 UMLS_CUI:C1266010 UMLS_CUI:C1518358 Papillary urothelial neoplasm of low malignant potential bladder PUNLMP bladder papillary neoplasm of low malignant potential disease_ontology DOID:6239 non-invasive bladder papillary urothelial neoplasm DOID:6245 MESH:C537750 NCI:C4526 OMIM:553000 SNOMEDCT_US_2016_03_01:254922006 UMLS_CUI:C0346255 Oncocytoma of kidney (disorder) renal epithelial Oncocytic tumor disease_ontology DOID:6245 OMIM mapping confirmed by DO. [SN]. renal oncocytoma DOID:6255 MESH:D049912 NCI:C7461 OMIM:102200 SNOMEDCT_US_2016_03_01:254957009 UMLS_CUI:C0346302 Growth Hormone Producing adenoma of the Pituitary Somatotroph adenoma (disorder) growth hormone secreting adenoma of pituitary disease_ontology DOID:6255 OMIM mapping confirmed by DO. [SN]. growth hormone secreting pituitary adenoma DOID:626 A primary immunodeficiency disease that is the result in a mutation of a gene encoding one of the thirty complement system proteins, produced predominantly in liver, which function to defend against infection and produce inflammation. ICD10CM:D80-D89 ICD10CM:D84.1 NCI:C4691 SNOMEDCT_US_2016_03_01:191014008 SNOMEDCT_US_2016_03_01:24743004 UMLS_CUI:C0272242 Complement deficiency Complement deficiency disease (disorder) disease_ontology DOID:626 complement deficiency DOID:627 A combined T cell and B cell immunodeficiency that is caused by a defect in several genes encoding for B and T lymphocytes resulting in individuals with non-functional immune systems. MESH:D016511 NCI:C3472 SNOMEDCT_US_2016_03_01:190994004 SNOMEDCT_US_2016_03_01:31323000 UMLS_CUI:C0085110 SCID combined T and B cell inborn immunodeficiency disease_ontology DOID:627 severe combined immunodeficiency DOID:6270 NCI:C6794 UMLS_CUI:C1333763 carcinoma of Cardia of stomach disease_ontology DOID:6270 gastric cardia carcinoma DOID:6271 NCI:C5247 UMLS_CUI:C1333762 adenocarcinoma of Cardia of stomach disease_ontology adenocarcinoma of gastric cardia DOID:6271 gastric cardia adenocarcinoma DOID:628 A primary immunodeficiency disease that involves multiple components of the immune system, including both humoral immunity and cell-mediated immunity. ICD10CM:D81 ICD10CM:D81.9 ICD9CM:279.2 NCI:C27871 OMIM:312863 ORDO:101972 SNOMEDCT_US_2016_03_01:191003005 UMLS_CUI:C0494261 Congenital Combined Immunodeficiency X-linked combined immunodeficiency combined immunodeficiency disease_ontology DOID:628 Xref MGI. combined T cell and B cell immunodeficiency DOID:630 A disease that has_material_basis_in genetic variations in the human genome. MESH:D030342 NCI:C3101 SNOMEDCT_US_2016_03_01:264530000 SNOMEDCT_US_2016_03_01:32895009 UMLS_CUI:C0019247 disease_ontology DOID:630 genetic disease DOID:631 ICD10CM:M79.1 ICD10CM:M79.7 MESH:D005356 NCI:C50566 NCI:C87497 SNOMEDCT_US_2016_03_01:1304004 SNOMEDCT_US_2016_03_01:13612005 SNOMEDCT_US_2016_03_01:156727006 SNOMEDCT_US_2016_03_01:203082005 SNOMEDCT_US_2016_03_01:203101004 SNOMEDCT_US_2016_03_01:203102006 SNOMEDCT_US_2016_03_01:203111006 SNOMEDCT_US_2016_03_01:203138004 SNOMEDCT_US_2016_03_01:24693007 SNOMEDCT_US_2016_03_01:247365004 SNOMEDCT_US_2016_03_01:268107007 SNOMEDCT_US_2016_03_01:56557000 UMLS_CUI:C0016053 disease_ontology DOID:631 fibromyalgia DOID:633 A myopathy characterized by muscle inflammation. ICD10CM:G72.49 ICD10CM:M60 ICD10CM:M60.9 MESH:D009220 NCI:C27578 OMIM:160750 SNOMEDCT_US_2016_03_01:128496001 SNOMEDCT_US_2016_03_01:203110007 SNOMEDCT_US_2016_03_01:268108002 SNOMEDCT_US_2016_03_01:26889001 UMLS_CUI:C0027121 Inflammatory disorder of muscle (disorder) disease_ontology DOID:633 OMIM mapping confirmed by DO. [SN]. myositis DOID:635 A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per µL of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS. EFO:0000765 ICD10CM:B20 MESH:D000163 NCI:C2851 OMIM:609423 SNOMEDCT_US_2016_03_01:186705005 SNOMEDCT_US_2016_03_01:186715004 SNOMEDCT_US_2016_03_01:234644008 SNOMEDCT_US_2016_03_01:266201009 SNOMEDCT_US_2016_03_01:62479008 UMLS_CUI:C0001175 AIDS acquired Immune deficiency disease_ontology acquired immune deficiency syndrome DOID:635 acquired immunodeficiency syndrome DOID:6364 A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing. DOID:12437 EFO:0003821 ICD10CM:G43 ICD10CM:G43.9 ICD10CM:G43.909 ICD9CM:346 ICD9CM:346.9 MESH:D008881 NCI:C89715 OMIM:157300 OMIM:613656 SNOMEDCT_US_2016_03_01:155046006 SNOMEDCT_US_2016_03_01:155048007 SNOMEDCT_US_2016_03_01:193030005 SNOMEDCT_US_2016_03_01:193036004 SNOMEDCT_US_2016_03_01:193041007 SNOMEDCT_US_2016_03_01:267699004 SNOMEDCT_US_2016_03_01:37796009 UMLS_CUI:C0042331 UMLS_CUI:C0149931 migraine disorder migraine variant migraine with or without aura disease_ontology DOID:6364 Xref MGI. OMIM mapping confirmed by DO. [SN]. migraine DOID:643 A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma. ICD10CM:A81.2 ICD9CM:046.3 MESH:D007968 NCI:C26815 SNOMEDCT_US_2016_03_01:22255007 UMLS_CUI:C0023524 disease_ontology PML DOID:643 progressive multifocal leukoencephalopathy DOID:6432 A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. ICD10CM:I27.2 MESH:D006976 NCI:C3120 SNOMEDCT_US_2016_03_01:155328008 SNOMEDCT_US_2016_03_01:266293003 SNOMEDCT_US_2016_03_01:70995007 UMLS_CUI:C0020542 disease_ontology DOID:6432 pulmonary hypertension DOID:6457 An autosomal dominant disease characterized by multiple noncancerous, tumor-like growths (hamartomas) and an increased risk of certain forms of cancer, especially breast, thyroid and endometrium. It is caused by mutations in the PTEN, SDHB, SDHD and KLLN genes. DOID:3471 MESH:D006223 NCI:C3076 NCI:C8419 OMIM:158350 OMIM:612359 OMIM:615106 OMIM:615107 OMIM:615108 OMIM:615109 ORDO:201 SNOMEDCT_US_2016_03_01:58037000 SNOMEDCT_US_2016_03_01:67944007 UMLS_CUI:C0018553 UMLS_CUI:C0391826 Lhermitte-Duclos disease (disorder) dysplastic Gangliocytoma of Cerebellum disease_ontology multiple hamartoma syndrome DOID:6457 Xref MGI. OMIM mapping confirmed by DO. [SN]. Cowden disease DOID:649 A brain disease that is characterized by brain damage resulting from the abnormal folding, clumping and accumulation of cellular proteins in the brain induced by prion proteins. ICD10CM:A81.9 KEGG:05020 MESH:D017096 NCI:C27585 SNOMEDCT_US_2016_03_01:193172009 SNOMEDCT_US_2016_03_01:20484008 SNOMEDCT_US_2016_03_01:230284004 UMLS_CUI:C0162534 Prion disease pathway Prion protein disease Spongiform Encephalopathy prion induced disorder transmissible spongiform encephalopathy disease_ontology DOID:649 prion disease DOID:65 A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage. MESH:D003240 NCI:C26729 SNOMEDCT_US_2016_03_01:105969002 SNOMEDCT_US_2016_03_01:201432001 SNOMEDCT_US_2016_03_01:268048008 SNOMEDCT_US_2016_03_01:268126004 UMLS_CUI:C0009782 connective tissue disorder disorder of connective tissue disease_ontology DOID:65 connective tissue disease DOID:653 An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism. ICD10CM:E79.8 ICD9CM:277.2 SNOMEDCT_US_2016_03_01:190917005 SNOMEDCT_US_2016_03_01:190922005 SNOMEDCT_US_2016_03_01:191109006 SNOMEDCT_US_2016_03_01:267450006 UMLS_CUI:C0029595 inborn errors of purine-pyrimidine metabolism disease_ontology DOID:653 purine-pyrimidine metabolic disorder DOID:6536 EFO:0000200 MESH:D010265 SNOMEDCT_US_2016_03_01:277576009 SNOMEDCT_US_2016_03_01:71390001 UMLS_CUI:C1136084 Plasma cell dyscrasia (disorder) Plasma cell tumour Plasmacytic tumor disease_ontology DOID:6536 plasma cell neoplasm DOID:654 MESH:D044343 SNOMEDCT_US_2016_03_01:302872003 UMLS_CUI:C1257763 disease_ontology DOID:654 Updated outdated UMLS CUI. overnutrition DOID:655 A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality. MESH:D008661 NCI:C34816 SNOMEDCT_US_2016_03_01:363205007 SNOMEDCT_US_2016_03_01:86095007 UMLS_CUI:C0025521 Inborn Errors of Metabolism Metabolic hereditary disorder inborn metabolism disorder disease_ontology DOID:655 inherited metabolic disorder DOID:6552 NCI:C6764 UMLS_CUI:C1333788 small cell carcinoma of stomach disease_ontology DOID:6552 gastric small cell carcinoma DOID:656 An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland. adenoma of the Adrenal gland disease_ontology DOID:656 adrenal adenoma DOID:657 A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures. DOID:2655 MESH:D000236 NCI:C2855 NCI:C4196 SNOMEDCT_US_2016_03_01:189578007 SNOMEDCT_US_2016_03_01:189579004 SNOMEDCT_US_2016_03_01:32048006 SNOMEDCT_US_2016_03_01:443416007 SNOMEDCT_US_2016_03_01:79041005 UMLS_CUI:C0001430 UMLS_CUI:C0334389 acinar cell adenoma acinar cell adenoma (morphologic abnormality) acinic cell adenoma adenomas disease_ontology adenoma DOID:657 adenoma DOID:6595 NCI:C5473 UMLS_CUI:C1333791 tubular adenocarcinoma of stomach disease_ontology DOID:6595 gastric tubular adenocarcinoma DOID:66 disease_ontology DOID:66 muscle tissue disease DOID:660 DOID:3949 ICD10CM:C74.0 MESH:D000306 NCI:C2858 NCI:C9327 SNOMEDCT_US_2016_03_01:127022002 SNOMEDCT_US_2016_03_01:18365006 SNOMEDCT_US_2016_03_01:189645007 SNOMEDCT_US_2016_03_01:189648009 SNOMEDCT_US_2016_03_01:2227007 SNOMEDCT_US_2016_03_01:363479004 SNOMEDCT_US_2016_03_01:371964008 SNOMEDCT_US_2016_03_01:93664009 UMLS_CUI:C0001618 UMLS_CUI:C0346402 Adrenal cortical tumors NOS (disorder) malignant Adrenocortical tumor malignant neoplasm of adrenal cortex malignant tumour of adrenal cortex neoplasm of adrenal cortex (disorder) disease_ontology DOID:660 adrenal cortex cancer DOID:6603 ICD10CM:M48.3 ICD9CM:721.7 SNOMEDCT_US_2016_03_01:111232005 SNOMEDCT_US_2016_03_01:156628006 SNOMEDCT_US_2016_03_01:202682000 SNOMEDCT_US_2016_03_01:240218006 SNOMEDCT_US_2016_03_01:268075001 SNOMEDCT_US_2016_03_01:65753008 UMLS_CUI:C0152088 Kummell disease Kummell's spondylitis Traumatic spondylopathy disease_ontology DOID:6603 Kummell's disease DOID:6658 DOID:5721 NCI:C5672 NCI:C6875 SNOMEDCT_US_2016_03_01:128628002 UMLS_CUI:C1265996 UMLS_CUI:C1334363 disease_ontology DOID:6658 pulmonary large cell neuroendocrine carcinoma DOID:668 A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles. MESH:D009221 NCI:C3253 SNOMEDCT_US_2016_03_01:156720008 SNOMEDCT_US_2016_03_01:203030008 SNOMEDCT_US_2016_03_01:44551007 UMLS_CUI:C0027122 Myisitis ossificans Ossification - muscle disease_ontology DOID:668 myositis ossificans DOID:6682 A bone structure disease that has_material_basis_in displacement located_in set of vertebrae. ICD10CM:M43.1 ICD10CM:M43.10 MESH:D013168 NCI:C35033 OMIM:184200 SNOMEDCT_US_2016_03_01:157003009 SNOMEDCT_US_2016_03_01:268349005 SNOMEDCT_US_2016_03_01:274152003 UMLS_CUI:C0038016 disease_ontology DOID:6682 spondylolisthesis DOID:6688 A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen. CSP:1560-5548 ICD10CM:D47.9 ICD10CM:D89.82 ICD9CM:279.41 MESH:D056735 NCI:C37864 OMIM:601859 ORDO:3261 SNOMEDCT_US_2016_03_01:702444009 UMLS_CUI:C1328840 ALPS (autoimmune lymphoproliferative syndrome) Canale-Smith syndrome disease_ontology DOID:6688 Xref MGI. OMIM mapping confirmed by DO. [SN]. autoimmune lymphoproliferative syndrome DOID:6713 An artery disease that is characterized by dysfunction of the blood vessels supplying the brain. DOID:12214 DOID:3455 DOID:8231 EFO:0000712 ICD10CM:I60-I69 ICD10CM:I63.9 ICD10CM:I67.9 ICD9CM:430-438.99 ICD9CM:437.9 MESH:D002561 MESH:D020521 NCI:C2938 NCI:C3390 OMIM:601367 SNOMEDCT_US_2016_03_01:155388006 SNOMEDCT_US_2016_03_01:155405006 SNOMEDCT_US_2016_03_01:155412002 SNOMEDCT_US_2016_03_01:195208004 SNOMEDCT_US_2016_03_01:195249004 SNOMEDCT_US_2016_03_01:195595007 SNOMEDCT_US_2016_03_01:230690007 SNOMEDCT_US_2016_03_01:266312006 SNOMEDCT_US_2016_03_01:266315008 SNOMEDCT_US_2016_03_01:270883006 SNOMEDCT_US_2016_03_01:313267000 SNOMEDCT_US_2016_03_01:62914000 SNOMEDCT_US_2016_03_01:82797006 UMLS_CUI:C0007820 UMLS_CUI:C0038454 CVA (cerebral vascular accident) Cerebrovascular accident (disorder) cerebrovascular accident cerebrovascular disorder stroke disease_ontology DOID:6713 OMIM mapping confirmed by DO. [SN]. cerebrovascular disease DOID:6725 A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord. DOID:10097 DOID:12235 ICD10CM:M48.0 ICD10CM:M48.00 ICD10CM:M48.02 ICD10CM:M48.06 ICD9CM:723.0 ICD9CM:724.00 MESH:D013130 SNOMEDCT_US_2016_03_01:156640006 SNOMEDCT_US_2016_03_01:156646000 SNOMEDCT_US_2016_03_01:18347007 SNOMEDCT_US_2016_03_01:202780000 SNOMEDCT_US_2016_03_01:202781001 SNOMEDCT_US_2016_03_01:202791007 SNOMEDCT_US_2016_03_01:268082002 SNOMEDCT_US_2016_03_01:76107001 SNOMEDCT_US_2016_03_01:83561009 UMLS_CUI:C0037944 UMLS_CUI:C0158280 UMLS_CUI:C0158288 Spinal stenosis of lumbar region cervical spinal stenosis lumbar spinal stenosis disease_ontology DOID:6725 spinal stenosis DOID:674 An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate. ICD10CM:Q35 ICD10CM:Q35.9 ICD9CM:749.0 ICD9CM:749.00 MESH:D002972 NCI:C87069 ORDO:99772 SNOMEDCT_US_2016_03_01:156940009 SNOMEDCT_US_2016_03_01:204593009 SNOMEDCT_US_2016_03_01:204605001 SNOMEDCT_US_2016_03_01:253986002 SNOMEDCT_US_2016_03_01:268196005 SNOMEDCT_US_2016_03_01:87979003 UMLS_CUI:C0008925 Palatoschisis Uranostaphyloschisis (disorder) cleft velum disease_ontology DOID:674 OMIM mapping confirmed by DO. [SN]. cleft palate DOID:676 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint. DOID:10129 DOID:1264 DOID:675 ICD10CM:M08.4 ICD10CM:M08.40 ICD9CM:714.3 ICD9CM:714.31 ICD9CM:714.32 ICD9CM:714.33 MESH:D001171 NCI:C26979 NCI:C61279 OMIM:604302 ORDO:92 SNOMEDCT_US_2016_03_01:201798003 SNOMEDCT_US_2016_03_01:201799006 SNOMEDCT_US_2016_03_01:201803007 SNOMEDCT_US_2016_03_01:201809006 SNOMEDCT_US_2016_03_01:74391003 SNOMEDCT_US_2016_03_01:7441009 SNOMEDCT_US_2016_03_01:75822003 SNOMEDCT_US_2016_03_01:83793004 UMLS_CUI:C0157916 UMLS_CUI:C0157917 UMLS_CUI:C0157918 UMLS_CUI:C0409667 Pauciarticular onset juvenile chronic arthritis acute juvenile rheumatoid arthritis juvenile chronic polyarthritis juvenile idiopathic arthritis monarticular juvenile rheumatoid arthritis pauciarticular juvenile arthritis systemic juvenile rheumatoid arthritis disease_ontology DOID:676 Xref MGI. juvenile rheumatoid arthritis DOID:678 A movement disease characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain. ICD10CM:G23.1 MESH:D013494 NCI:C85028 OMIM:601104 OMIM:609454 OMIM:610898 ORDO:683 SNOMEDCT_US_2016_03_01:192975003 SNOMEDCT_US_2016_03_01:192976002 SNOMEDCT_US_2016_03_01:28978003 UMLS_CUI:C0038868 Steele-Richardson-Olszewski syndrome progressive supranuclear ophthalmoplegia disease_ontology DOID:678 Xref MGI. OMIM mapping confirmed by DO. [SN]. progressive supranuclear palsy DOID:679 CSP:2057-3403 MESH:D001480 SNOMEDCT_US_2016_03_01:70835005 UMLS_CUI:C0004782 disease_ontology DOID:679 basal ganglia disease DOID:680 A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain. MESH:D024801 UMLS_CUI:C0949664 disease_ontology DOID:680 tauopathy DOID:682 ICD10CM:T79.A0 ICD9CM:958.90 MESH:D003161 NCI:C118422 SNOMEDCT_US_2016_03_01:111245009 SNOMEDCT_US_2016_03_01:212379008 SNOMEDCT_US_2016_03_01:45781009 UMLS_CUI:C0009492 Compartment syndrome Compartment syndrome (disorder) Compartmental syndrome, NOS disease_ontology DOID:682 compartment syndrome DOID:6823 MESH:C537162 NCI:C4265 SNOMEDCT_US_2016_03_01:189814006 SNOMEDCT_US_2016_03_01:53618008 UMLS_CUI:C0334489 Pancreatoblastoma (morphologic abnormality) disease_ontology DOID:6823 pancreatoblastoma DOID:684 A liver carcinoma that has_material_basis_in undifferentiated hepatocytes. DOID:5005 EFO:0000182 NCI:C7711 NCI:C7956 OMIM:114550 UMLS_CUI:C0279607 HCC Hepatoma adult Hepatoma adult primary hepatocellular carcinoma disease_ontology DOID:684 OMIM mapping confirmed by DO. [SN]. hepatocellular carcinoma DOID:686 A liver cancer that has_material_basis_in epithelial cells. NCI:C7927 UMLS_CUI:C0279000 Liver and Intrahepatic bile duct carcinoma disease_ontology DOID:686 liver carcinoma DOID:687 ICD10CM:C22.2 MESH:D018197 NCI:C3728 SNOMEDCT_US_2016_03_01:109843000 SNOMEDCT_US_2016_03_01:45024009 UMLS_CUI:C0206624 HBL disease_ontology DOID:687 hepatoblastoma DOID:6888 NCI:C4830 SNOMEDCT_US_2016_03_01:300988009 UMLS_CUI:C0577692 transitional cell carcinoma of ureter (disorder) ureteral Urothelial cell carcinoma disease_ontology DOID:6888 ureter transitional cell carcinoma DOID:6929 ICD10CM:H35.81 ICD9CM:362.83 MESH:D010211 SNOMEDCT_US_2016_03_01:193426002 SNOMEDCT_US_2016_03_01:6141006 UMLS_CUI:C0242420 disease_ontology DOID:6929 retinal edema DOID:693 MESH:D003744 NCI:C34529 SNOMEDCT_US_2016_03_01:196277000 SNOMEDCT_US_2016_03_01:26597004 SNOMEDCT_US_2016_03_01:699382004 SNOMEDCT_US_2016_03_01:699421005 UMLS_CUI:C0011351 Enamel Hypoplasia Enamel hypoplasia Enamel hypoplasia (disorder) disease_ontology DOID:693 dental enamel hypoplasia DOID:6933 DOID:2141 NCI:C3842 NCI:C39858 SNOMEDCT_US_2016_03_01:154620001 SNOMEDCT_US_2016_03_01:189459005 SNOMEDCT_US_2016_03_01:269642004 SNOMEDCT_US_2016_03_01:313414002 SNOMEDCT_US_2016_03_01:45083001 UMLS_CUI:C0235754 UMLS_CUI:C1384678 Urothelial papilloma Urothelial papilloma (morphologic abnormality) bladder papilloma bladder papilloma NOS bladder papilloma NOS (disorder) transitional cell papilloma of bladder urinary bladder Urothelial papilloma disease_ontology DOID:6933 bladder transitional cell papilloma DOID:698 MESH:D003807 NCI:C50778 SNOMEDCT_US_2016_03_01:13468005 UMLS_CUI:C0011432 Sensitive dentin disease_ontology DOID:698 dentin sensitivity DOID:6988 NCI:C27473 UMLS_CUI:C1333306 disease_ontology DOID:6988 peripheral epithelioid sarcoma DOID:699 A myopathy that is characterized by mitochondrial dysfunction. MESH:D017240 NCI:C101328 OMIM:251900 SNOMEDCT_US_2016_03_01:16851005 SNOMEDCT_US_2016_03_01:240096000 UMLS_CUI:C0162670 mitochondrial cytopathy (disorder) disease_ontology DOID:699 OMIM mapping confirmed by DO. [SN]. mitochondrial myopathy DOID:7 A disease that manifests in a defined anatomical structure. DOID:1 DOID:2 DOID:5 DOID:71 DOID:72 DOID:8 disease_ontology DOID:7 disease of anatomical entity DOID:700 An inherited metabolic disorder that involves mitochondrial metabolism dysfunction. MESH:D028361 SNOMEDCT_US_2016_03_01:240096000 UMLS_CUI:C0751651 disease_ontology DOID:700 mitochondrial metabolism disease DOID:7017 NCI:C6500 UMLS_CUI:C1334438 disease_ontology DOID:7017 lumbosacral lipoma DOID:705 ICD10CM:H47.22 MESH:D029242 NCI:C84808 OMIM:535000 SNOMEDCT_US_2016_03_01:194045006 SNOMEDCT_US_2016_03_01:230510002 SNOMEDCT_US_2016_03_01:58610003 UMLS_CUI:C0917796 Leber's hereditary optic neuropathy Leber's optic atrophy Leber's optic atrophy (disorder) disease_ontology DOID:705 OMIM mapping confirmed by DO. [SN]. Leber hereditary optic neuropathy DOID:706 EFO:0000096 NCI:C27910 UMLS_CUI:C1334633 mature B-cell lymphocytic neoplasm disease_ontology DOID:706 mature B-cell neoplasm DOID:7061 NCI:C8936 UMLS_CUI:C0862030 disease_ontology DOID:7061 precursor B lymphoblastic lymphoma/leukemia DOID:707 A non-Hodgkin lymphoma that has_material_basis_in B cells. MESH:D016393 NCI:C27907 NCI:C3457 SNOMEDCT_US_2016_03_01:109979007 SNOMEDCT_US_2016_03_01:1929004 SNOMEDCT_US_2016_03_01:413616009 UMLS_CUI:C0079731 B-cell lymphocytic neoplasm disease_ontology DOID:707 B-cell lymphoma DOID:7147 A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage. EFO:0003898 ICD10CM:M45 ICD9CM:720.0 MESH:D013167 NCI:C84564 ORDO:825 SNOMEDCT_US_2016_03_01:156619005 SNOMEDCT_US_2016_03_01:9631008 UMLS_CUI:C0038013 Bekhterev syndrome Bekhterev's disease Marie-Strumpell disease disease_ontology DOID:7147 ankylosing spondylitis DOID:7148 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C27206 NCI:C2884 OMIM:180300 SNOMEDCT_US_2016_03_01:156471009 SNOMEDCT_US_2016_03_01:156481008 SNOMEDCT_US_2016_03_01:287010008 SNOMEDCT_US_2016_03_01:69896004 UMLS_CUI:C0003873 Arthritis or polyarthritis, rheumatic atrophic Arthritis disease_ontology DOID:7148 OMIM mapping confirmed by DO. [SN]. rheumatoid arthritis DOID:715 MESH:D015458 UMLS_CUI:C0023492 disease_ontology DOID:715 T-cell leukemia DOID:7165 ICD10CM:E06.1 ICD9CM:245.1 MESH:D013968 NCI:C35071 NCI:C35828 SNOMEDCT_US_2016_03_01:154666006 SNOMEDCT_US_2016_03_01:190296009 SNOMEDCT_US_2016_03_01:237530000 SNOMEDCT_US_2016_03_01:237531001 SNOMEDCT_US_2016_03_01:237532008 SNOMEDCT_US_2016_03_01:237533003 SNOMEDCT_US_2016_03_01:38727009 SNOMEDCT_US_2016_03_01:428041004 UMLS_CUI:C0040149 De Quervain's thyroiditis Giant-cell thyroiditis Granulomatous thyroiditis Subacute Granulomatous Thyroiditis Subacute Thyroiditis Subacute thyroiditis (disorder) de Quervain's thyroiditis disease_ontology DOID:7165 subacute thyroiditis DOID:7166 ICD10CM:E06 ICD10CM:E06.9 ICD9CM:245 ICD9CM:245.9 MESH:D013966 NCI:C26894 SNOMEDCT_US_2016_03_01:154664009 SNOMEDCT_US_2016_03_01:154668007 SNOMEDCT_US_2016_03_01:190301009 SNOMEDCT_US_2016_03_01:82119001 UMLS_CUI:C0040147 disease_ontology DOID:7166 Updating to more specific UMLS_CUI from C0029495 to C0040147. thyroiditis DOID:718 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies. CSP:0427-1178 ICD9CM:283.0 MESH:D000744 NCI:C34378 OMIM:205700 SNOMEDCT_US_2016_03_01:154803002 SNOMEDCT_US_2016_03_01:191209000 SNOMEDCT_US_2016_03_01:191215000 SNOMEDCT_US_2016_03_01:25121006 SNOMEDCT_US_2016_03_01:413603009 UMLS_CUI:C0002880 Autoimmune haemolytic anaemia Autoimmune hemolytic anemia NOS (disorder) disease_ontology DOID:718 OMIM mapping confirmed by DO. [SN]. autoimmune hemolytic anemia DOID:7188 An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues. DOID:0050435 ICD10CM:E06.3 MESH:D013967 NCI:C38766 SNOMEDCT_US_2016_03_01:190297000 SNOMEDCT_US_2016_03_01:21983002 SNOMEDCT_US_2016_03_01:66944004 UMLS_CUI:C0920350 Chronic Lymphocytic Thyroiditis Hashimoto thyroiditis Hashimoto's Disease Hashimoto's syndrome Hashimoto's thyroiditis Lymphocytic Thyroiditis disease_ontology DOID:7188 OMIM mapping confirmed by DO. [SN]. autoimmune thyroiditis DOID:720 NCI:C35142 SNOMEDCT_US_2016_03_01:300980002 UMLS_CUI:C0085577 ANEMIA NORMOCYTIC Normocytic anemia (disorder) disease_ontology DOID:720 normocytic anemia DOID:731 An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra. MESH:D014571 NCI:C3431 SNOMEDCT_US_2016_03_01:126879004 SNOMEDCT_US_2016_03_01:254913005 UMLS_CUI:C0042076 neoplasm of urinary system tumor of the urinary system tumor of urinary tract urinary tract neoplasm disease_ontology DOID:731 urinary system benign neoplasm DOID:7319 NCI:C27301 SNOMEDCT_US_2016_03_01:60703000 UMLS_CUI:C0270921 disease_ontology DOID:7319 axonal neuropathy DOID:732 A urinary system disease that is located_in the urethra. ICD10CM:N36.9 MESH:D014522 NCI:C26903 SNOMEDCT_US_2016_03_01:197945001 SNOMEDCT_US_2016_03_01:198551002 SNOMEDCT_US_2016_03_01:4985009 UMLS_CUI:C0041969 urethra disease disease_ontology DOID:732 urethral disease DOID:7378 NCI:C27343 UMLS_CUI:C0948740 disease_ontology DOID:7378 pituitary hypoplasia DOID:74 An immune system disease that has_material_basis_in hematopoietic cells. ICD10CM:D75.9 ICD9CM:280-289.99 ICD9CM:289.9 MESH:D006402 NCI:C26323 SNOMEDCT_US_2016_03_01:154785002 SNOMEDCT_US_2016_03_01:154842002 SNOMEDCT_US_2016_03_01:191124002 SNOMEDCT_US_2016_03_01:191402006 SNOMEDCT_US_2016_03_01:191446003 SNOMEDCT_US_2016_03_01:267552000 SNOMEDCT_US_2016_03_01:267573000 SNOMEDCT_US_2016_03_01:34093004 UMLS_CUI:C0018939 Blood disease Blood dyscrasia NOS DISEASE OF THE BLOOD AND BLOOD-FORMING ORGANS Hematological disease blood disorder disease of hematopoietic system disease_ontology DOID:74 hematopoietic system disease DOID:7400 MESH:D049932 NCI:C4692 OMIM:251260 SNOMEDCT_US_2016_03_01:234638009 UMLS_CUI:C0398791 Berlin breakage syndrome Microcephaly, normal intelligence and immunodeficiency (disorder) Seemanova syndrome disease_ontology DOID:7400 OMIM mapping confirmed by DO. [SN]. Nijmegen breakage syndrome DOID:7427 A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath. ICD10CM:A22 ICD10CM:A22.9 ICD9CM:022 ICD9CM:022.9 MESH:D000881 NCI:C84565 SNOMEDCT_US_2016_03_01:154295005 SNOMEDCT_US_2016_03_01:17540007 SNOMEDCT_US_2016_03_01:186304006 SNOMEDCT_US_2016_03_01:187302001 SNOMEDCT_US_2016_03_01:409498004 UMLS_CUI:C0003175 disease_ontology DOID:7427 anthrax disease DOID:7455 disease_ontology DOID:7455 hypogonadotropism DOID:7457 A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching. DOID:7458 ICD10CM:B80 MESH:D010123 SNOMEDCT_US_2016_03_01:154415009 SNOMEDCT_US_2016_03_01:187178006 SNOMEDCT_US_2016_03_01:19722001 SNOMEDCT_US_2016_03_01:266162007 SNOMEDCT_US_2016_03_01:266222003 UMLS_CUI:C0030100 Oxyuris vermicularis infection (disorder) Threadworm infection disease_ontology Enterobius vermicularis infection Pinworm infection oxyuriasis DOID:7457 enterobiasis DOID:7459 NCI:C40359 UMLS_CUI:C1519485 disease_ontology DOID:7459 acantholytic variant squamous cell breast carcinoma DOID:746 ICD10CM:D19.9 MESH:D018254 NCI:C3762 SNOMEDCT_US_2016_03_01:189835008 SNOMEDCT_US_2016_03_01:2348006 SNOMEDCT_US_2016_03_01:41183007 UMLS_CUI:C0206675 adenomatoid tumor (morphologic abnormality) adenomatoid tumor NOS (morphologic abnormality) benign localized epithelial Mesothelioma disease_ontology DOID:746 adenomatoid tumor DOID:7465 NCI:C39591 UMLS_CUI:C1512709 NK-cell large granular Lymphocyte Lymphocytosis disease_ontology DOID:7465 chronic NK-cell lymphocytosis DOID:7475 An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall. MESH:D004238 NCI:C26752 SNOMEDCT_US_2016_03_01:155779000 SNOMEDCT_US_2016_03_01:18126004 SNOMEDCT_US_2016_03_01:197095003 SNOMEDCT_US_2016_03_01:197102009 SNOMEDCT_US_2016_03_01:197103004 SNOMEDCT_US_2016_03_01:307496006 UMLS_CUI:C0012813 disease_ontology DOID:7475 diverticulitis DOID:749 disease_ontology GI Bleeding DOID:749 active peptic ulcer disease DOID:75 An immune system disease that is located_in the lymphatic system. MESH:D008206 SNOMEDCT_US_2016_03_01:111590001 SNOMEDCT_US_2016_03_01:155452000 SNOMEDCT_US_2016_03_01:234087005 SNOMEDCT_US_2016_03_01:266326002 SNOMEDCT_US_2016_03_01:3305006 SNOMEDCT_US_2016_03_01:362971004 UMLS_CUI:C0024228 Adenopathy Lymphangiopathy, NOS Lymphatic disease Lymphatic disorder disease of lympoid system disorder of lymph node and lymphatics (disorder) disorder of lymphatic system disorder of lymphoid system lymphatic disorder lympoid system disease disease_ontology DOID:75 lymphatic system disease DOID:750 DOID:11466 DOID:12635 DOID:13115 ICD10CM:K27 ICD9CM:533 MESH:D010437 NCI:C3318 SNOMEDCT_US_2016_03_01:13200003 SNOMEDCT_US_2016_03_01:155701001 SNOMEDCT_US_2016_03_01:155710009 SNOMEDCT_US_2016_03_01:196681007 SNOMEDCT_US_2016_03_01:196697002 SNOMEDCT_US_2016_03_01:196704007 SNOMEDCT_US_2016_03_01:196705008 SNOMEDCT_US_2016_03_01:266437002 SNOMEDCT_US_2016_03_01:266501005 UMLS_CUI:C0030920 acute peptic ulcer with hemorrhage acute peptic ulcer with hemorrhage and perforation acute peptic ulcer without hemorrhage AND without perforation (disorder) acute peptic ulcer without hemorrhage and without perforation disease_ontology DOID:750 peptic ulcer disease DOID:752 DOID:751 MESH:D010439 SNOMEDCT_US_2016_03_01:155703003 SNOMEDCT_US_2016_03_01:196700003 SNOMEDCT_US_2016_03_01:266502003 SNOMEDCT_US_2016_03_01:88169003 UMLS_CUI:C0030925 Peptic ulcer with perforation (disorder) Perforated peptic ulcer Unspecified peptic ulcer with perforation (disorder) acute peptic ulcer with perforation disease_ontology DOID:752 peptic ulcer perforation DOID:7541 NCI:C40364 UMLS_CUI:C1513365 disease_ontology DOID:7541 mixed epithelial/mesenchymal metaplastic breast carcinoma DOID:758 ICD10CM:Q89.3 ICD9CM:759.3 MESH:D012857 NCI:C87121 OMIM:270100 SNOMEDCT_US_2016_03_01:157025003 SNOMEDCT_US_2016_03_01:157033002 SNOMEDCT_US_2016_03_01:205765000 SNOMEDCT_US_2016_03_01:205770007 SNOMEDCT_US_2016_03_01:254257004 SNOMEDCT_US_2016_03_01:268359006 SNOMEDCT_US_2016_03_01:27317008 SNOMEDCT_US_2016_03_01:43876007 UMLS_CUI:C0037221 Complete transposition (morphologic abnormality) Laterality sequence (disorder) situs inversus viscerum (disorder) disease_ontology DOID:758 OMIM mapping confirmed by DO. [LS]. situs inversus DOID:7596 NCI:C27925 UMLS_CUI:C1332337 disease_ontology DOID:7596 asbestos-related lung carcinoma DOID:76 A gastrointestinal system disease that is located_in the stomach. MESH:D013272 NCI:C26886 SNOMEDCT_US_2016_03_01:155671005 SNOMEDCT_US_2016_03_01:183927002 SNOMEDCT_US_2016_03_01:196598004 SNOMEDCT_US_2016_03_01:266497000 SNOMEDCT_US_2016_03_01:29384001 UMLS_CUI:C0038354 Gastropathy stomach disorder disease_ontology gastric disease DOID:76 stomach disease DOID:7608 MESH:D010282 NCI:C3916 SNOMEDCT_US_2016_03_01:128474007 UMLS_CUI:C0262587 adenoma of the Parathyroid gland disease_ontology adenoma of parathyroid DOID:7608 parathyroid adenoma DOID:7633 MESH:D012167 NCI:C34795 SNOMEDCT_US_2016_03_01:193388002 SNOMEDCT_US_2016_03_01:232006002 UMLS_CUI:C0024441 Macular hole disease_ontology DOID:7633 macular holes DOID:767 MESH:D009133 NCI:C94834 SNOMEDCT_US_2016_03_01:155014006 SNOMEDCT_US_2016_03_01:156721007 SNOMEDCT_US_2016_03_01:203036002 SNOMEDCT_US_2016_03_01:249827008 SNOMEDCT_US_2016_03_01:267693003 SNOMEDCT_US_2016_03_01:268104000 SNOMEDCT_US_2016_03_01:88092000 UMLS_CUI:C0026846 Amyotrophia Muscle wasting Wasting - muscle disease_ontology DOID:767 muscular atrophy DOID:768 A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina. MESH:D012175 NCI:C6956 NCI:C7541 OMIM:180200 SNOMEDCT_US_2016_03_01:134191003 SNOMEDCT_US_2016_03_01:154553002 SNOMEDCT_US_2016_03_01:189934006 SNOMEDCT_US_2016_03_01:189935007 SNOMEDCT_US_2016_03_01:19906005 SNOMEDCT_US_2016_03_01:269614001 SNOMEDCT_US_2016_03_01:370967009 UMLS_CUI:C0035335 RB RB - Retinoblastoma neuroblastoma of Retina disease_ontology DOID:768 OMIM mapping confirmed by DO. [LS]. retinoblastoma DOID:769 An autonomic nervous system neoplasm that derives_from immature nerve cells. EFO:0000621 MESH:D009447 NCI:C3270 OMIM:256700 OMIM:613013 OMIM:613014 OMIM:613015 OMIM:613016 ORDO:635 SNOMEDCT_US_2016_03_01:189931003 SNOMEDCT_US_2016_03_01:269507008 SNOMEDCT_US_2016_03_01:432328008 SNOMEDCT_US_2016_03_01:87364003 UMLS_CUI:C0027819 neuroblastoma (Schwannian Stroma-Poor) disease_ontology DOID:769 Xref MGI. OMIM mapping confirmed by DO. [SN]. neuroblastoma DOID:77 A disease of anatomical entity that is located_in the gastrointestinal tract. DOID:27 DOID:944 ICD10CM:K92.9 ICD9CM:520-579.99 MESH:D004066 SNOMEDCT_US_2016_03_01:155629009 SNOMEDCT_US_2016_03_01:155847001 SNOMEDCT_US_2016_03_01:197575000 SNOMEDCT_US_2016_03_01:266483008 SNOMEDCT_US_2016_03_01:53619000 UMLS_CUI:C0012242 GIT disease Gastroenteropathy alimentary system disease digestive system disorder gastrointestinal disease gastrointestinal disorder disease_ontology DOID:77 gastrointestinal system disease DOID:771 A malignant neoplasm that derives_from the retina. NCI:C7061 UMLS_CUI:C1335765 disease_ontology DOID:771 retinal cell cancer DOID:7725 An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type. MESH:D004830 NCI:C3022 SNOMEDCT_US_2016_03_01:352818000 UMLS_CUI:C0014549 Epileptic seizures, tonic-clonic Grand Mal epilepsy tonic-clonic epilepsy disease_ontology DOID:7725 epilepsy with generalized tonic-clonic seizures DOID:7736 ICD9CM:362.15 SNOMEDCT_US_2016_03_01:84884003 UMLS_CUI:C0154835 disease_ontology DOID:7736 retinal telangiectasia DOID:7765 ICD10CM:H35.02 ICD10CM:H35.07 ICD9CM:362.12 MESH:D058456 OMIM:300216 SNOMEDCT_US_2016_03_01:193359003 SNOMEDCT_US_2016_03_01:193360008 SNOMEDCT_US_2016_03_01:25506007 SNOMEDCT_US_2016_03_01:360455002 UMLS_CUI:C0154832 Coats' disease Coats' syndrome Exudative retinopathy disease_ontology DOID:7765 OMIM mapping confirmed by DO. [SN]. Coats disease DOID:778 A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect. ICD10CM:F22 ICD9CM:297.1 MESH:D012563 NCI:C94379 SNOMEDCT_US_2016_03_01:192330005 SNOMEDCT_US_2016_03_01:48500005 UMLS_CUI:C0011251 disease_ontology DOID:778 delusional disorder DOID:780 A uterine disease that is located_in the placenta. DOID:1815 DOID:5366 DOID:9219 ICD10CM:O43 ICD10CM:O43.9 ICD10CM:O43.90 ICD9CM:646.9 MESH:D010922 MESH:D011248 NCI:C26857 NCI:C27619 NCI:C34941 NCI:C35169 SNOMEDCT_US_2016_03_01:125586008 SNOMEDCT_US_2016_03_01:156069003 SNOMEDCT_US_2016_03_01:156097009 SNOMEDCT_US_2016_03_01:156123001 SNOMEDCT_US_2016_03_01:156131006 SNOMEDCT_US_2016_03_01:172422001 SNOMEDCT_US_2016_03_01:173300003 SNOMEDCT_US_2016_03_01:198881004 SNOMEDCT_US_2016_03_01:199152008 SNOMEDCT_US_2016_03_01:23288008 SNOMEDCT_US_2016_03_01:267293009 SNOMEDCT_US_2016_03_01:267311008 SNOMEDCT_US_2016_03_01:267314000 SNOMEDCT_US_2016_03_01:90821003 UMLS_CUI:C0032045 UMLS_CUI:C0032962 UMLS_CUI:C0151864 UMLS_CUI:C1335423 disease_ontology DOID:780 placenta disease DOID:784 EFO:0003884 ICD10CM:N18.9 ICD9CM:585.6 MESH:D007676 NCI:C9438 SNOMEDCT_US_2016_03_01:155856009 SNOMEDCT_US_2016_03_01:197654000 SNOMEDCT_US_2016_03_01:197655004 SNOMEDCT_US_2016_03_01:197755007 SNOMEDCT_US_2016_03_01:46177005 SNOMEDCT_US_2016_03_01:90688005 UMLS_CUI:C0022661 CKD CRF chronic kidney failure chronic renal disease chronic renal failure syndrome renal failure - chronic disease_ontology DOID:784 chronic kidney disease DOID:786 ICD10CM:J38.7 ICD10CM:S12.8 ICD9CM:478.70 MESH:D007818 NCI:C26810 SNOMEDCT_US_2016_03_01:195863001 SNOMEDCT_US_2016_03_01:60600009 UMLS_CUI:C0023051 disease_ontology DOID:786 laryngeal disease DOID:7894 A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae. ICD10CM:B88.0 ICD10CM:B88.9 ICD9CM:133 ICD9CM:133.9 MESH:D008924 SNOMEDCT_US_2016_03_01:154422001 SNOMEDCT_US_2016_03_01:187214007 SNOMEDCT_US_2016_03_01:187217000 SNOMEDCT_US_2016_03_01:240885009 SNOMEDCT_US_2016_03_01:266224002 SNOMEDCT_US_2016_03_01:78166003 UMLS_CUI:C0026229 disease_ontology DOID:7894 mite infestation DOID:799 A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin. ICD10CM:I83.90 MESH:D014648 NCI:C35114 OMIM:192200 SNOMEDCT_US_2016_03_01:128060009 SNOMEDCT_US_2016_03_01:12856003 SNOMEDCT_US_2016_03_01:155468006 SNOMEDCT_US_2016_03_01:155482006 SNOMEDCT_US_2016_03_01:234053000 SNOMEDCT_US_2016_03_01:266331000 SNOMEDCT_US_2016_03_01:276504003 SNOMEDCT_US_2016_03_01:399989005 UMLS_CUI:C0042345 Varix Venous ectasia Venous varices varices disease_ontology DOID:799 varicose veins DOID:7997 A thyroid gland disease that is characterized by excess thyroid hormone. ICD10CM:E05.9 ICD9CM:242 MESH:D013971 NCI:C61469 OMIM:275000 SNOMEDCT_US_2016_03_01:154655004 SNOMEDCT_US_2016_03_01:154659005 SNOMEDCT_US_2016_03_01:190239004 SNOMEDCT_US_2016_03_01:190267008 SNOMEDCT_US_2016_03_01:267373004 SNOMEDCT_US_2016_03_01:267464006 SNOMEDCT_US_2016_03_01:286909009 SNOMEDCT_US_2016_03_01:90739004 UMLS_CUI:C0040156 disease_ontology DOID:7997 OMIM mapping confirmed by DO. [LS]. thyrotoxicosis DOID:7998 A thyroid gland disease that involves an over production of thyroid hormone. ICD10CM:E05.9 MESH:D006980 NCI:C3123 OMIM:603373 OMIM:609152 ORDO:99819 SNOMEDCT_US_2016_03_01:154655004 SNOMEDCT_US_2016_03_01:190239004 SNOMEDCT_US_2016_03_01:267464006 SNOMEDCT_US_2016_03_01:34486009 UMLS_CUI:C0020550 overactive thyroid disease_ontology DOID:7998 Xref MGI. hyperthyroidism DOID:8025 NCI:C5250 UMLS_CUI:C1335965 Signet Ring cell adenocarcinoma of the stomach disease_ontology DOID:8025 gastric signet ring cell adenocarcinoma DOID:809 A substance abuse that involves the recurring use of cocaine despite negative consequences. ICD10CM:F14.1 ICD9CM:305.6 ICD9CM:305.60 MESH:D019970 SNOMEDCT_US_2016_03_01:78267003 UMLS_CUI:C0009171 disease_ontology DOID:809 cocaine abuse DOID:8102 NCI:C4160 SNOMEDCT_US_2016_03_01:30301008 UMLS_CUI:C0334328 Microfollicular adenoma (morphologic abnormality) disease_ontology DOID:8102 fetal adenoma DOID:811 ICD10CM:E88.1 ICD9CM:272.6 MESH:D008060 NCI:C97093 SNOMEDCT_US_2016_03_01:190789006 SNOMEDCT_US_2016_03_01:190790002 SNOMEDCT_US_2016_03_01:71325002 UMLS_CUI:C0023787 disease_ontology DOID:811 lipodystrophy DOID:8125 An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone. DOID:7490 ICD10CM:M92 ICD10CM:M93.9 ICD9CM:732.6 MESH:D055034 NCI:C34879 SNOMEDCT_US_2016_03_01:123256004 SNOMEDCT_US_2016_03_01:156822009 SNOMEDCT_US_2016_03_01:19579005 SNOMEDCT_US_2016_03_01:203398006 SNOMEDCT_US_2016_03_01:268125000 SNOMEDCT_US_2016_03_01:65477003 UMLS_CUI:C0029429 UMLS_CUI:C0158445 (Osteochondrosis NOS) or (apophysitis NOS) or (epiphysitis NOS) or (osteochondritis NOS) Epiphyseal necrosis, NOS Osteochondrosis not specified as adult or juvenile, of unspecified site osteochondritis juvenilis disease_ontology DOID:8125 osteochondrosis DOID:813 An arthritis that involves infection by a pathogen located_in joint. DOID:10920 DOID:12314 DOID:14519 DOID:1683 DOID:2002 DOID:2003 DOID:812 ICD10CM:M00 ICD10CM:M00.9 ICD9CM:711.0 ICD9CM:711.9 ICD9CM:711.90 ICD9CM:711.91 ICD9CM:711.92 ICD9CM:711.93 ICD9CM:711.94 ICD9CM:711.95 ICD9CM:711.96 ICD9CM:711.97 MESH:D001170 NCI:C26700 SNOMEDCT_US_2016_03_01:156470005 SNOMEDCT_US_2016_03_01:196415003 SNOMEDCT_US_2016_03_01:201455003 SNOMEDCT_US_2016_03_01:201471003 SNOMEDCT_US_2016_03_01:201591007 SNOMEDCT_US_2016_03_01:201592000 SNOMEDCT_US_2016_03_01:201593005 SNOMEDCT_US_2016_03_01:201594004 SNOMEDCT_US_2016_03_01:201595003 SNOMEDCT_US_2016_03_01:201596002 SNOMEDCT_US_2016_03_01:201597006 SNOMEDCT_US_2016_03_01:201598001 SNOMEDCT_US_2016_03_01:201599009 SNOMEDCT_US_2016_03_01:201623005 SNOMEDCT_US_2016_03_01:239776008 SNOMEDCT_US_2016_03_01:371412008 SNOMEDCT_US_2016_03_01:372938004 SNOMEDCT_US_2016_03_01:372939007 SNOMEDCT_US_2016_03_01:396234004 SNOMEDCT_US_2016_03_01:428437005 SNOMEDCT_US_2016_03_01:48548006 SNOMEDCT_US_2016_03_01:55388007 SNOMEDCT_US_2016_03_01:83486002 UMLS_CUI:C0003869 UMLS_CUI:C0157843 UMLS_CUI:C0157844 UMLS_CUI:C0157845 UMLS_CUI:C0157846 UMLS_CUI:C0157847 UMLS_CUI:C0157848 UMLS_CUI:C0157849 infectious arthritis disease_ontology DOID:813 septic arthritis DOID:8200 A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems. ICD10CM:A52 ICD10CM:A52.3 ICD10CM:A52.9 ICD9CM:097.0 MESH:C536774 SNOMEDCT_US_2016_03_01:186905004 SNOMEDCT_US_2016_03_01:187358009 SNOMEDCT_US_2016_03_01:276200006 SNOMEDCT_US_2016_03_01:72083004 UMLS_CUI:C0153188 late syphilis disease_ontology DOID:8200 tertiary syphilis DOID:824 EFO:0000649 ICD10CM:K05.3 MESH:D010518 NCI:C34918 SNOMEDCT_US_2016_03_01:155648008 SNOMEDCT_US_2016_03_01:266491004 SNOMEDCT_US_2016_03_01:41565005 UMLS_CUI:C0031099 chronic pericementitis disease_ontology DOID:824 periodontitis DOID:8295 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades. ICD10CM:B86 ICD9CM:133.0 MESH:D012532 NCI:C34998 SNOMEDCT_US_2016_03_01:128869009 SNOMEDCT_US_2016_03_01:154422001 SNOMEDCT_US_2016_03_01:187215008 SNOMEDCT_US_2016_03_01:266224002 SNOMEDCT_US_2016_03_01:67172004 UMLS_CUI:C0036262 Infestation by Sarcoptes scabiei Infestation by Sarcoptes scabiei var hominis Sarcoptic itch disease_ontology DOID:8295 scabies DOID:83 A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision. ICD10CM:H26 ICD9CM:366.8 MESH:D002386 OMIM:601371 SNOMEDCT_US_2016_03_01:193620000 SNOMEDCT_US_2016_03_01:193622008 UMLS_CUI:C0029531 disease_ontology DOID:83 Xref MGI. cataract DOID:8337 A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever. DOID:10275 DOID:10276 DOID:10947 ICD10CM:K37 ICD9CM:540-543.99 ICD9CM:541 MESH:D001064 NCI:C35145 SNOMEDCT_US_2016_03_01:155728006 SNOMEDCT_US_2016_03_01:155729003 SNOMEDCT_US_2016_03_01:155733005 SNOMEDCT_US_2016_03_01:155736002 SNOMEDCT_US_2016_03_01:196785005 SNOMEDCT_US_2016_03_01:307530000 SNOMEDCT_US_2016_03_01:74400008 UMLS_CUI:C0003615 acute appendicitis acute appendicitis with generalized peritonitis acute appendicitis with generalized peritonitis (disorder) acute appendicitis with peritoneal abscess acute appendicitis with peritoneal abscess (disorder) disease_ontology DOID:8337 appendicitis DOID:8354 NCI:C9468 OMIM:613779 ORDO:280133 UMLS_CUI:C1332655 C3 deficiency disease_ontology DOID:8354 Xref MGI. complement component 3 deficiency DOID:8398 An arthritis that has_material_basis_in worn out cartilage located_in joint. EFO:0002506 ICD9CM:715.3 OMIM:140600 OMIM:165720 OMIM:607850 OMIM:610839 OMIM:612400 OMIM:612401 UMLS_CUI:C0157946 Osteoarthrosis and allied disorder degenerative arthritis degenerative joint disease hypertrophic arthritis osteoarthrosis disease_ontology DOID:8398 Xref MGI. osteoarthritis DOID:841 An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss. DOID:2707 ICD10CM:J67.9 ICD9CM:495 ICD9CM:495.9 MESH:D000542 NCI:C34369 SNOMEDCT_US_2016_03_01:155581001 SNOMEDCT_US_2016_03_01:195993008 SNOMEDCT_US_2016_03_01:195994002 SNOMEDCT_US_2016_03_01:266399001 SNOMEDCT_US_2016_03_01:37471005 UMLS_CUI:C0002390 alveolitis hypersensitivity pneumonitis disease_ontology DOID:841 extrinsic allergic alveolitis DOID:8411 NCI:C3888 SNOMEDCT_US_2016_03_01:254921004 UMLS_CUI:C0241961 Angiomyolipoma of kidney (disorder) renal Angiomyolipoma disease_ontology DOID:8411 kidney angiomyolipoma DOID:8432 ICD10CM:D75.1 MESH:D011086 NCI:C26863 SNOMEDCT_US_2016_03_01:109992005 SNOMEDCT_US_2016_03_01:127062003 SNOMEDCT_US_2016_03_01:165401000 SNOMEDCT_US_2016_03_01:44865000 UMLS_CUI:C0032461 Erythrocythemia disease_ontology DOID:8432 polycythemia DOID:8437 ICD10CM:K56.60 ICD10CM:K56.69 ICD9CM:560.9 MESH:D007415 NCI:C9175 SNOMEDCT_US_2016_03_01:155771002 SNOMEDCT_US_2016_03_01:155777003 SNOMEDCT_US_2016_03_01:197072007 SNOMEDCT_US_2016_03_01:197073002 SNOMEDCT_US_2016_03_01:197074008 SNOMEDCT_US_2016_03_01:197080000 SNOMEDCT_US_2016_03_01:266523009 SNOMEDCT_US_2016_03_01:81060008 UMLS_CUI:C0021843 disease_ontology DOID:8437 intestinal obstruction DOID:8440 MESH:D045823 NCI:C37979 SNOMEDCT_US_2016_03_01:278524008 SNOMEDCT_US_2016_03_01:81060008 UMLS_CUI:C1258215 Ileus of intestine disease_ontology DOID:8440 ileus DOID:8443 A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus. ICD9CM:353.0 SNOMEDCT_US_2016_03_01:193109004 SNOMEDCT_US_2016_03_01:3548001 UMLS_CUI:C0006091 Brachial plexus lesions Brachial plexus lesions NOS (disorder) disease_ontology DOID:8443 brachial plexus lesion DOID:8445 ICD10CM:K56.2 ICD9CM:560.2 MESH:D045822 NCI:C98963 SNOMEDCT_US_2016_03_01:155774005 SNOMEDCT_US_2016_03_01:197057008 SNOMEDCT_US_2016_03_01:197061002 SNOMEDCT_US_2016_03_01:90738007 SNOMEDCT_US_2016_03_01:9707006 UMLS_CUI:C0042961 Twist of intestine, bowel, or colon Volvulus intestinal volvulus disease_ontology DOID:8445 intestinal volvulus DOID:8446 ICD10CM:K56.1 ICD9CM:560.0 MESH:D007443 NCI:C113484 OMIM:147710 SNOMEDCT_US_2016_03_01:155772009 SNOMEDCT_US_2016_03_01:197055000 SNOMEDCT_US_2016_03_01:35327006 SNOMEDCT_US_2016_03_01:49723003 UMLS_CUI:C0021933 Intussusception (morphologic abnormality) Intussusception NOS (disorder) Intussusception of intestine (disorder) Invagination of intestine or colon disease_ontology DOID:8446 OMIM mapping confirmed by DO. [SN]. intussusception DOID:845 A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes. ICD10CM:F34.0 ICD9CM:301.1 ICD9CM:301.10 ICD9CM:301.13 MESH:D003527 SNOMEDCT_US_2016_03_01:14697007 SNOMEDCT_US_2016_03_01:191751008 SNOMEDCT_US_2016_03_01:191752001 SNOMEDCT_US_2016_03_01:191754000 SNOMEDCT_US_2016_03_01:191755004 SNOMEDCT_US_2016_03_01:192383002 SNOMEDCT_US_2016_03_01:268756002 SNOMEDCT_US_2016_03_01:286737005 SNOMEDCT_US_2016_03_01:386798001 SNOMEDCT_US_2016_03_01:76105009 UMLS_CUI:C0010598 Affective personality disorder Cycloid personality Cyclothymia Cyclothymic personality disease_ontology DOID:845 cyclothymic disorder DOID:8454 ICD10CM:E53.0 ICD9CM:266.0 MESH:D012257 SNOMEDCT_US_2016_03_01:154726004 SNOMEDCT_US_2016_03_01:20307000 SNOMEDCT_US_2016_03_01:267492001 UMLS_CUI:C0035528 vitamin B2 deficiency disease_ontology DOID:8454 ariboflavinosis DOID:8456 MESH:D002796 SNOMEDCT_US_2016_03_01:238113006 UMLS_CUI:C0008412 Choline deficiency (disorder) choline deficiency disease_ontology DOID:8456 choline deficiency disease DOID:8457 ICD10CM:E52 ICD9CM:265.2 MESH:D010383 SNOMEDCT_US_2016_03_01:154725000 SNOMEDCT_US_2016_03_01:238127001 SNOMEDCT_US_2016_03_01:267491008 SNOMEDCT_US_2016_03_01:418186002 SNOMEDCT_US_2016_03_01:418279001 SNOMEDCT_US_2016_03_01:56550003 UMLS_CUI:C0030783 Niacin deficiency Niacin-tryptophan deficiency Pellagra disease_ontology DOID:8457 pellagra DOID:8461 A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye. MESH:D058540 NCI:C35256 OMIM:304050 ORDO:50 SNOMEDCT_US_2016_03_01:80651009 UMLS_CUI:C0175713 disease_ontology DOID:8461 OMIM mapping confirmed by DO. [SN]. Aicardi syndrome DOID:8465 ICD10CM:H33.10 ICD9CM:361.10 MESH:D041441 NCI:C85046 SNOMEDCT_US_2016_03_01:193330003 SNOMEDCT_US_2016_03_01:389992006 SNOMEDCT_US_2016_03_01:44268007 UMLS_CUI:C0152439 disease_ontology DOID:8465 retinoschisis DOID:8466 A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina. MESH:D012162 NCI:C34979 SNOMEDCT_US_2016_03_01:95695004 UMLS_CUI:C0035304 RETINA degeneration degeneration of retina disease_ontology DOID:8466 retinal degeneration DOID:8469 A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness. DOID:8468 ICD10CM:J11.1 ICD9CM:487 MESH:D007251 NCI:C53482 SNOMEDCT_US_2016_03_01:155559006 SNOMEDCT_US_2016_03_01:155562009 SNOMEDCT_US_2016_03_01:195931008 SNOMEDCT_US_2016_03_01:266353003 SNOMEDCT_US_2016_03_01:266393000 SNOMEDCT_US_2016_03_01:6142004 UMLS_CUI:C0021400 Influenza with non-respiratory manifestation (disorder) Influenza with other manifestations Influenza with other manifestations (disorder) Influenza with other manifestations NOS (disorder) flu influenza with non-respiratory manifestation disease_ontology DOID:8469 influenza DOID:848 A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint. ICD10CM:M19.90 MESH:D001168 NCI:C2883 SNOMEDCT_US_2016_03_01:202059001 SNOMEDCT_US_2016_03_01:363178003 SNOMEDCT_US_2016_03_01:372091005 SNOMEDCT_US_2016_03_01:3723001 UMLS_CUI:C0003864 Inflammatory disorder of joint disease_ontology arthritis DOID:848 arthritis DOID:8488 A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac. ICD10CM:O40 ICD9CM:657 ICD9CM:657.0 MESH:D006831 NCI:C92848 SNOMEDCT_US_2016_03_01:156188008 SNOMEDCT_US_2016_03_01:157052008 SNOMEDCT_US_2016_03_01:199644009 SNOMEDCT_US_2016_03_01:199645005 SNOMEDCT_US_2016_03_01:199648007 SNOMEDCT_US_2016_03_01:199650004 SNOMEDCT_US_2016_03_01:267261001 SNOMEDCT_US_2016_03_01:405235009 SNOMEDCT_US_2016_03_01:86203003 UMLS_CUI:C0020224 disease_ontology DOID:8488 polyhydramnios DOID:8498 ICD10CM:H53.63 ICD9CM:368.61 MESH:C537743 SNOMEDCT_US_2016_03_01:193687000 SNOMEDCT_US_2016_03_01:193688005 SNOMEDCT_US_2016_03_01:193689002 SNOMEDCT_US_2016_03_01:89208008 UMLS_CUI:C1306122 Congenital night blindness Oguchi's disease disease_ontology DOID:8498 OMIM mapping confirmed by DO. [SN]. hereditary night blindness DOID:8499 ICD10CM:H53.6 ICD10CM:H53.60 ICD9CM:368.6 ICD9CM:368.60 MESH:D009755 NCI:C34850 NCI:C37997 SNOMEDCT_US_2016_03_01:155144006 SNOMEDCT_US_2016_03_01:193686009 SNOMEDCT_US_2016_03_01:193693008 SNOMEDCT_US_2016_03_01:65194006 SNOMEDCT_US_2016_03_01:75390007 UMLS_CUI:C0028077 disease_ontology DOID:8499 night blindness DOID:850 A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. DOID:11894 DOID:11895 DOID:29 DOID:766 ICD10CM:J98.4 MESH:D008171 NCI:C3198 SNOMEDCT_US_2016_03_01:196164004 SNOMEDCT_US_2016_03_01:19829001 SNOMEDCT_US_2016_03_01:266374002 UMLS_CUI:C0024115 disease_ontology DOID:850 Updating out dated CUI and removing lung abscess as a synonym. lung disease DOID:8501 MESH:D058499 NCI:C35625 SNOMEDCT_US_2016_03_01:314407005 UMLS_CUI:C0854723 Retinal Dystrophy disease_ontology DOID:8501 fundus dystrophy DOID:8504 A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous. ICD10CM:L01 ICD10CM:L01.0 ICD10CM:L01.00 ICD9CM:684 MESH:D007169 NCI:C99088 SNOMEDCT_US_2016_03_01:156319000 SNOMEDCT_US_2016_03_01:200710001 SNOMEDCT_US_2016_03_01:267836006 SNOMEDCT_US_2016_03_01:48277006 UMLS_CUI:C0021099 disease_ontology DOID:8504 impetigo DOID:8515 A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs. ICD10CM:I27.81 ICD10CM:I27.9 MESH:D011660 SNOMEDCT_US_2016_03_01:155323004 SNOMEDCT_US_2016_03_01:155329000 SNOMEDCT_US_2016_03_01:194879006 SNOMEDCT_US_2016_03_01:266294009 SNOMEDCT_US_2016_03_01:274096000 SNOMEDCT_US_2016_03_01:286952009 SNOMEDCT_US_2016_03_01:83291003 UMLS_CUI:C0034072 cardiopulmonary disease pulmonary heart disease disease_ontology DOID:8515 Cor pulmonale DOID:8534 ICD10CM:K21 ICD10CM:K21.9 ICD9CM:530.81 MESH:D005764 NCI:C26781 NCI:C92560 OMIM:109350 SNOMEDCT_US_2016_03_01:102620007 SNOMEDCT_US_2016_03_01:155673008 SNOMEDCT_US_2016_03_01:196600005 SNOMEDCT_US_2016_03_01:196624002 SNOMEDCT_US_2016_03_01:235595009 SNOMEDCT_US_2016_03_01:266498005 SNOMEDCT_US_2016_03_01:54856001 SNOMEDCT_US_2016_03_01:698065002 UMLS_CUI:C0017168 Acid reflux GERD GERD - Gastro-esophageal reflux disease Gastresophageal reflux Gastro-esophageal reflux Gastroesophageal reflux Gastroesophageal reflux disease disease_ontology DOID:8534 OMIM mapping confirmed by DO. [SN]. gastroesophageal reflux disease DOID:854 MESH:D003095 NCI:C27204 SNOMEDCT_US_2016_03_01:156458006 SNOMEDCT_US_2016_03_01:201434000 SNOMEDCT_US_2016_03_01:201454004 SNOMEDCT_US_2016_03_01:268048008 SNOMEDCT_US_2016_03_01:81573002 UMLS_CUI:C0009326 collagen disorder disease_ontology DOID:854 collagen disease DOID:8541 DOID:8790 ICD10CM:C84.1 ICD10CM:C84.10 ICD9CM:202.2 MESH:D012751 NCI:C3366 SNOMEDCT_US_2016_03_01:118611004 SNOMEDCT_US_2016_03_01:188629004 SNOMEDCT_US_2016_03_01:188638002 SNOMEDCT_US_2016_03_01:4950009 UMLS_CUI:C0036920 Sezary disease Sezary syndrome disease_ontology DOID:8541 Sezary's disease DOID:8544 A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions. ICD10CM:G93.3 ICD10CM:R53.82 ICD9CM:780.71 MESH:D015673 NCI:C3037 SNOMEDCT_US_2016_03_01:154989001 SNOMEDCT_US_2016_03_01:154991009 SNOMEDCT_US_2016_03_01:155062000 SNOMEDCT_US_2016_03_01:192735003 SNOMEDCT_US_2016_03_01:193054000 SNOMEDCT_US_2016_03_01:247372003 SNOMEDCT_US_2016_03_01:267683005 SNOMEDCT_US_2016_03_01:267684004 SNOMEDCT_US_2016_03_01:271798008 SNOMEDCT_US_2016_03_01:51771007 SNOMEDCT_US_2016_03_01:52702003 UMLS_CUI:C0015674 CFS Myalgic encephalitis Myalgic encephalomyelitis Postviral fatigue syndrome (disorder) disease_ontology DOID:8544 No OMIM mapping, confirmed by DO. [LS]. chronic fatigue syndrome DOID:8545 A genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature. ICD10CM:T88.3 ICD9CM:995.86 MESH:D008305 NCI:C84869 OMIM:145600 OMIM:154275 OMIM:154276 OMIM:600467 OMIM:601887 OMIM:601888 ORDO:423 SNOMEDCT_US_2016_03_01:111738008 SNOMEDCT_US_2016_03_01:157762007 SNOMEDCT_US_2016_03_01:213026003 SNOMEDCT_US_2016_03_01:248453001 SNOMEDCT_US_2016_03_01:269435009 SNOMEDCT_US_2016_03_01:405500008 SNOMEDCT_US_2016_03_01:405501007 UMLS_CUI:C0024591 anesthesia related hyperthermia malignant hyperpyrexia due to anesthesia disease_ontology DOID:8545 Xref MGI. OMIM mapping confirmed by DO. [SN]. malignant hyperthermia DOID:8549 DOID:8548 DOID:8733 ICD10CM:L98.4 ICD9CM:707 SNOMEDCT_US_2016_03_01:156423009 SNOMEDCT_US_2016_03_01:156426001 SNOMEDCT_US_2016_03_01:19429009 SNOMEDCT_US_2016_03_01:201259007 UMLS_CUI:C0157738 Callous ulcer (morphologic abnormality) Indolent ulcer (morphologic abnormality) disease_ontology DOID:8549 chronic ulcer of skin DOID:8553 ICD10CM:L88 ICD9CM:686.01 MESH:D017511 SNOMEDCT_US_2016_03_01:74578003 UMLS_CUI:C0085652 Pyoderma gangrenosum (disorder) disease_ontology DOID:8553 pyoderma gangrenosum DOID:8557 A pharynx cancer that is located_in the oropharynx. DOID:8684 DOID:8851 DOID:8949 DOID:9168 ICD10CM:C10 ICD10CM:C10.2 ICD10CM:C10.3 ICD10CM:C10.8 ICD10CM:C10.9 ICD9CM:146 ICD9CM:146.5 ICD9CM:146.6 ICD9CM:146.7 ICD9CM:146.9 NCI:C7398 SNOMEDCT_US_2016_03_01:187686007 SNOMEDCT_US_2016_03_01:187688008 SNOMEDCT_US_2016_03_01:187691008 SNOMEDCT_US_2016_03_01:363392002 SNOMEDCT_US_2016_03_01:373653002 SNOMEDCT_US_2016_03_01:448868009 SNOMEDCT_US_2016_03_01:93933005 SNOMEDCT_US_2016_03_01:93971002 UMLS_CUI:C0153382 UMLS_CUI:C0153388 UMLS_CUI:C0153389 UMLS_CUI:C0153390 Oropharyngeal carcinoma malignant Oropharyngeal tumor malignant neoplasm of junctional region of oropharynx malignant neoplasm of lateral wall of oropharynx malignant neoplasm of oropharynx malignant neoplasm of posterior wall of oropharynx malignant tumor of oropharynx (disorder) malignant tumor of posterior wall of oropharynx (disorder) malignant tumour of mesopharynx (disorder) oropharyngeal cancer primary malignant neoplasm of lateral wall of oropharynx disease_ontology DOID:8557 oropharynx cancer DOID:8564 DOID:8563 DOID:8605 DOID:8975 DOID:9031 DOID:9135 ICD10CM:C00 ICD10CM:C00.9 ICD9CM:140 ICD9CM:140.6 ICD9CM:140.8 MESH:D008048 NCI:C7485 SNOMEDCT_US_2016_03_01:187599002 SNOMEDCT_US_2016_03_01:187625008 SNOMEDCT_US_2016_03_01:187626009 SNOMEDCT_US_2016_03_01:309808004 SNOMEDCT_US_2016_03_01:363348004 SNOMEDCT_US_2016_03_01:363374005 SNOMEDCT_US_2016_03_01:93762003 SNOMEDCT_US_2016_03_01:93869001 UMLS_CUI:C0153340 UMLS_CUI:C0153346 UMLS_CUI:C0153347 malignant neoplasm of commissure of lip malignant neoplasm of external Lip, not specified as upper or lower malignant neoplasm of labial commissure of lip malignant neoplasm of lip unspecified, inner aspect (disorder) malignant neoplasm of lip, inner aspect malignant neoplasm of lip, inner aspect NOS (disorder) malignant neoplasm of lip, unspecified malignant neoplasm of lip, unspecified (disorder) malignant neoplasm of lip, unspecified, external (disorder) malignant neoplasm of lip, unspecified, inner aspect malignant neoplasm of lip, unspecified, vermilion border malignant neoplasm of lip, vermilion border NOS (disorder) malignant neoplasm of lower lip, buccal aspect (disorder) malignant neoplasm of lower lip, inner aspect NOS (disorder) malignant neoplasm of lower lip, mucosa (disorder) malignant neoplasm of lower lip, oral aspect malignant neoplasm of oral aspect of lip, not specified whether upper or lower malignant neoplasm of other sites of lip malignant neoplasm of other sites of lip (disorder) malignant neoplasm of vermilion border of lip malignant neoplasm of vermilion border of lip unspecified (disorder) malignant tumor of commissure of lip malignant tumor of commissure of lip (disorder) malignant tumor of labial mucosa (disorder) malignant tumor of lip (disorder) malignant tumor of lower labial mucosa (disorder) malignant tumor of the Lip malignant tumour of labial commissure malignant tumour of lip disease_ontology DOID:8564 lip cancer DOID:8566 A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person. DOID:8763 DOID:9012 DOID:9239 ICD10CM:B00 ICD10CM:B00.9 ICD9CM:054 MESH:D006561 SNOMEDCT_US_2016_03_01:154332007 SNOMEDCT_US_2016_03_01:186534002 SNOMEDCT_US_2016_03_01:266191005 SNOMEDCT_US_2016_03_01:88594005 UMLS_CUI:C0019348 Herpesvirus hominis disease disease_ontology DOID:8566 herpes simplex DOID:8567 A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell. DOID:0060059 DOID:8652 DOID:8671 DOID:8685 DOID:8710 DOID:8715 DOID:8841 DOID:8953 DOID:9096 DOID:9107 EFO:0000183 ICD10CM:C81 ICD10CM:C81.9 ICD9CM:201 ICD9CM:201.0 ICD9CM:201.1 ICD9CM:201.2 ICD9CM:201.9 MESH:D006689 NCI:C26956 NCI:C6914 NCI:C9357 OMIM:236000 OMIM:300221 OMIM:400021 ORDO:98293 SNOMEDCT_US_2016_03_01:118599009 SNOMEDCT_US_2016_03_01:118602004 SNOMEDCT_US_2016_03_01:118605002 SNOMEDCT_US_2016_03_01:118606001 SNOMEDCT_US_2016_03_01:14537002 SNOMEDCT_US_2016_03_01:154582001 SNOMEDCT_US_2016_03_01:188521005 SNOMEDCT_US_2016_03_01:188522003 SNOMEDCT_US_2016_03_01:188532005 SNOMEDCT_US_2016_03_01:188533000 SNOMEDCT_US_2016_03_01:188542007 SNOMEDCT_US_2016_03_01:188543002 SNOMEDCT_US_2016_03_01:188552006 SNOMEDCT_US_2016_03_01:188595005 SNOMEDCT_US_2016_03_01:188596006 SNOMEDCT_US_2016_03_01:188605006 SNOMEDCT_US_2016_03_01:189987006 SNOMEDCT_US_2016_03_01:189991001 SNOMEDCT_US_2016_03_01:189992008 SNOMEDCT_US_2016_03_01:269509006 SNOMEDCT_US_2016_03_01:309831004 SNOMEDCT_US_2016_03_01:46923007 SNOMEDCT_US_2016_03_01:52337003 SNOMEDCT_US_2016_03_01:70600005 SNOMEDCT_US_2016_03_01:74189002 UMLS_CUI:C0019829 HL Hodgkin disease Hodgkin lymphoma Hodgkin's sarcoma Hodgkins lymphoma stage I Subdiaphragmatic Hodgkin Lymphoma stage II Subdiaphragmatic Hodgkin Lymphoma disease_ontology DOID:8567 Xref MGI. OMIM mapping confirmed by DO. [SN]. Hodgkin's lymphoma DOID:8574 ICD10CM:L28.0 ICD9CM:697 ICD9CM:697.9 SNOMEDCT_US_2016_03_01:156376003 SNOMEDCT_US_2016_03_01:156379005 SNOMEDCT_US_2016_03_01:200998004 SNOMEDCT_US_2016_03_01:201010002 SNOMEDCT_US_2016_03_01:88996004 UMLS_CUI:C0023643 disease_ontology DOID:8574 lichen disease DOID:8577 A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores. DOID:8576 DOID:9016 EFO:0000729 ICD10CM:K51 ICD10CM:K51.9 ICD9CM:556 ICD9CM:556.5 ICD9CM:556.9 MESH:D003093 NCI:C2952 OMIM:266600 SNOMEDCT_US_2016_03_01:155764007 SNOMEDCT_US_2016_03_01:196985000 SNOMEDCT_US_2016_03_01:196988003 SNOMEDCT_US_2016_03_01:196996008 SNOMEDCT_US_2016_03_01:266447004 SNOMEDCT_US_2016_03_01:27701000 SNOMEDCT_US_2016_03_01:441971007 SNOMEDCT_US_2016_03_01:64766004 SNOMEDCT_US_2016_03_01:68195006 UMLS_CUI:C0009324 UMLS_CUI:C0375359 Left-sided ulcerative colitis disease_ontology DOID:8577 OMIM mapping confirmed by DO. [LS]. ulcerative colitis DOID:8580 DOID:8579 ICD10CM:C96.A ICD9CM:202.3 MESH:D054747 NCI:C7202 SNOMEDCT_US_2016_03_01:118612006 SNOMEDCT_US_2016_03_01:128920006 SNOMEDCT_US_2016_03_01:134179007 SNOMEDCT_US_2016_03_01:188643009 SNOMEDCT_US_2016_03_01:188690006 SNOMEDCT_US_2016_03_01:277648007 SNOMEDCT_US_2016_03_01:66855003 SNOMEDCT_US_2016_03_01:8139000 UMLS_CUI:C0019623 Histiocytic medullary reticulosis [obs] Stewart's granuloma malignant midline reticulosis malignant reticulosis disease_ontology DOID:8580 malignant histiocytosis DOID:8584 A mature B-cell neoplasm of B-cells found in the germinal center. ICD10CM:C83.7 ICD10CM:C83.70 ICD9CM:200.2 MESH:D002051 NCI:C2912 NCI:C7400 OMIM:113970 SNOMEDCT_US_2016_03_01:118617000 SNOMEDCT_US_2016_03_01:154581008 SNOMEDCT_US_2016_03_01:188509006 SNOMEDCT_US_2016_03_01:188518008 SNOMEDCT_US_2016_03_01:190022008 SNOMEDCT_US_2016_03_01:190023003 SNOMEDCT_US_2016_03_01:22197008 SNOMEDCT_US_2016_03_01:277571004 SNOMEDCT_US_2016_03_01:397400006 SNOMEDCT_US_2016_03_01:77381001 UMLS_CUI:C0006413 Burkitt lymphoma/leukaemia Burkitt's Lymphoma Burkitt's tumor Burkitt's tumor or lymphoma malignant lymphoma, Burkitt's type small Non-Cleaved cell Lymphoma, Burkitt's type disease_ontology DOID:8584 OMIM mapping confirmed by DO. [SN]. Burkitt lymphoma DOID:8596 An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash. DOID:8597 ICD10CM:A38 ICD10CM:A38.9 ICD9CM:034 ICD9CM:034.1 MESH:D012541 NCI:C94575 SNOMEDCT_US_2016_03_01:154301006 SNOMEDCT_US_2016_03_01:154303009 SNOMEDCT_US_2016_03_01:154304003 SNOMEDCT_US_2016_03_01:186357007 SNOMEDCT_US_2016_03_01:186362008 SNOMEDCT_US_2016_03_01:30242009 UMLS_CUI:C0036285 UMLS_CUI:C0343487 Scarlatina disease_ontology DOID:8596 scarlet fever DOID:8602 DOID:8734 ICD10CM:C03 ICD10CM:C03.9 ICD9CM:143 ICD9CM:143.9 NCI:C9317 SNOMEDCT_US_2016_03_01:187651005 SNOMEDCT_US_2016_03_01:363382005 SNOMEDCT_US_2016_03_01:93819009 UMLS_CUI:C0153364 malignant Gingival tumor malignant neoplasm of gum malignant neoplasm of gum NOS (disorder) malignant neoplasm of other sites of gum malignant neoplasm of other sites of gum (disorder) malignant tumor of gum (disorder) malignant tumour of gingiva disease_ontology DOID:8602 gum cancer DOID:8618 A gastrointestinal system cancer that is located_in the oral cavity. DOID:0050627 DOID:8617 DOID:9049 DOID:9055 ICD10CM:C04 ICD10CM:C04.0 ICD10CM:C04.1 ICD10CM:C04.9 ICD9CM:144 ICD9CM:144.0 ICD9CM:144.1 ICD9CM:144.9 NCI:C9318 SNOMEDCT_US_2016_03_01:187652003 SNOMEDCT_US_2016_03_01:187653008 SNOMEDCT_US_2016_03_01:187656000 SNOMEDCT_US_2016_03_01:363385007 SNOMEDCT_US_2016_03_01:93672006 SNOMEDCT_US_2016_03_01:93802007 SNOMEDCT_US_2016_03_01:93860002 UMLS_CUI:C0153368 UMLS_CUI:C0153369 UMLS_CUI:C0496758 malignant neoplasm of anterior portion of floor of mouth malignant neoplasm of floor of mouth malignant neoplasm of lateral floor of mouth malignant neoplasm of lateral portion of floor of mouth malignant tumor of anterior floor of mouth (disorder) malignant tumor of lateral floor of mouth (disorder) malignant tumor of the Floor of the Mouth disease_ontology DOID:8618 oral cavity cancer DOID:8619 A sleep disorder that involves recurring bouts of excessive amounts of sleepiness. ICD10CM:G47.13 ICD9CM:327.13 MESH:D006970 SNOMEDCT_US_2016_03_01:426451004 UMLS_CUI:C0751226 primary recurrent hypersomnia disease_ontology DOID:8619 recurrent hypersomnia DOID:8622 A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash. DOID:8621 DOID:8963 DOID:9112 ICD10CM:B05 ICD10CM:B05.9 ICD9CM:055 MESH:D008457 NCI:C96406 SNOMEDCT_US_2016_03_01:14189004 SNOMEDCT_US_2016_03_01:154338006 UMLS_CUI:C0025007 morbilli disease_ontology DOID:8622 measles DOID:863 A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system. ICD10CM:G00-G99 ICD10CM:G98 ICD10CM:G98.8 ICD9CM:349.9 MESH:D009422 NCI:C26835 SNOMEDCT_US_2016_03_01:118940003 SNOMEDCT_US_2016_03_01:154981003 SNOMEDCT_US_2016_03_01:155262005 SNOMEDCT_US_2016_03_01:192641002 SNOMEDCT_US_2016_03_01:267679005 SNOMEDCT_US_2016_03_01:286946008 UMLS_CUI:C0027765 disease_ontology DOID:863 nervous system disease DOID:8632 A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8). DOID:12761 DOID:12762 DOID:12764 DOID:12766 DOID:12767 DOID:12768 DOID:12770 DOID:12771 DOID:12772 DOID:12774 DOID:12775 DOID:12776 DOID:12777 DOID:12778 DOID:6480 DOID:7239 DOID:8631 ICD10CM:C46 ICD10CM:C46.0 ICD10CM:C46.1 ICD10CM:C46.2 ICD10CM:C46.3 ICD10CM:C46.4 ICD10CM:C46.5 ICD10CM:C46.9 ICD9CM:176 ICD9CM:176.0 ICD9CM:176.1 ICD9CM:176.2 ICD9CM:176.3 ICD9CM:176.4 ICD9CM:176.5 ICD9CM:176.9 MESH:D012514 NCI:C27500 NCI:C3550 NCI:C3551 NCI:C4578 NCI:C4579 NCI:C5363 NCI:C5523 NCI:C5529 NCI:C5602 NCI:C5706 NCI:C5842 NCI:C6377 NCI:C6749 NCI:C7006 NCI:C9087 OMIM:148000 SNOMEDCT_US_2016_03_01:109385007 SNOMEDCT_US_2016_03_01:109386008 SNOMEDCT_US_2016_03_01:109387004 SNOMEDCT_US_2016_03_01:109388009 SNOMEDCT_US_2016_03_01:109390005 SNOMEDCT_US_2016_03_01:109391009 SNOMEDCT_US_2016_03_01:154604006 SNOMEDCT_US_2016_03_01:188029000 SNOMEDCT_US_2016_03_01:188144002 SNOMEDCT_US_2016_03_01:188483007 SNOMEDCT_US_2016_03_01:188775002 SNOMEDCT_US_2016_03_01:190112000 SNOMEDCT_US_2016_03_01:255114007 SNOMEDCT_US_2016_03_01:255115008 SNOMEDCT_US_2016_03_01:49937004 UMLS_CUI:C0036220 UMLS_CUI:C0153560 UMLS_CUI:C0153561 UMLS_CUI:C0153562 UMLS_CUI:C0153563 UMLS_CUI:C0153564 UMLS_CUI:C0153565 UMLS_CUI:C0346935 UMLS_CUI:C0346936 UMLS_CUI:C1332265 UMLS_CUI:C1332847 UMLS_CUI:C1333453 UMLS_CUI:C1333744 UMLS_CUI:C1333776 UMLS_CUI:C1334318 UMLS_CUI:C1334457 UMLS_CUI:C1335372 UMLS_CUI:C1335509 Conjunctival Kaposi's sarcoma Corneal Kaposi's sarcoma Cutaneous Kaposi's sarcoma Kaposi sarcoma Kaposi's sarcoma of Heart Kaposi's sarcoma of anus Kaposi's sarcoma of central nervous system Kaposi's sarcoma of conjunctiva (disorder) Kaposi's sarcoma of cornea (disorder) Kaposi's sarcoma of esophagus Kaposi's sarcoma of gastrointestinal sites Kaposi's sarcoma of lung (disorder) Kaposi's sarcoma of lymph nodes Kaposi's sarcoma of lymph nodes (disorder) Kaposi's sarcoma of palate (disorder) Kaposi's sarcoma of penis Kaposi's sarcoma of skin Kaposi's sarcoma of skin (disorder) Kaposi's sarcoma of soft tissue (disorder) Kaposi's sarcoma of soft tissues (disorder) Kaposi's sarcoma of the CNS Kaposi's sarcoma of the gallbladder Kaposi's sarcoma of the prostate Kaposi's sarcoma, lung Kaposi's sarcoma, skin Palate Kaposi's sarcoma anal Kaposi's sarcoma cardiac Kaposi's sarcoma central nervous system Kaposi's sarcoma conjunctival Kaposi's sarcoma corneal Kaposi's sarcoma cutaneous Kaposi's sarcoma esophageal Kaposi's sarcoma gallbladder Kaposi's sarcoma gastric Kaposi's sarcoma intestinal Kaposi's sarcoma lymph node Kaposi's sarcoma lymphadenopathic Kaposi's sarcoma palate Kaposi's sarcoma penis Kaposi's sarcoma prostate Kaposi's sarcoma pulmonary Kaposi's sarcoma soft tissue Kaposi's sarcoma disease_ontology African lymphadenopathic Kaposi's sarcoma Kaposi's sarcoma-associated herpesvirus (KSHV) DOID:8632 OMIM mapping confirmed by DO. [SN]. Kaposi's sarcoma DOID:8643 DOID:8897 DOID:8983 ICD10CM:K29.8 ICD9CM:535.6 MESH:D004382 NCI:C94409 SNOMEDCT_US_2016_03_01:155715004 SNOMEDCT_US_2016_03_01:72007001 UMLS_CUI:C0013298 Hemorrhagic duodenitis disease_ontology DOID:8643 duodenitis DOID:8646 ICD9CM:293.89 UMLS_CUI:C0154334 disease_ontology DOID:8646 substance-induced psychosis DOID:8649 DOID:8648 DOID:8779 DOID:8900 DOID:8940 DOID:8999 DOID:9058 DOID:9068 DOID:9196 ICD10CM:C01 ICD10CM:C02.0 ICD10CM:C02.1 ICD10CM:C02.2 ICD10CM:C02.4 ICD10CM:C02.9 ICD9CM:141 ICD9CM:141.0 ICD9CM:141.1 ICD9CM:141.2 ICD9CM:141.3 ICD9CM:141.5 ICD9CM:141.6 ICD9CM:141.9 MESH:D014062 NCI:C3524 NCI:C9345 SNOMEDCT_US_2016_03_01:187632004 SNOMEDCT_US_2016_03_01:187633009 SNOMEDCT_US_2016_03_01:187636001 SNOMEDCT_US_2016_03_01:187637005 SNOMEDCT_US_2016_03_01:187638000 SNOMEDCT_US_2016_03_01:187642002 SNOMEDCT_US_2016_03_01:187644001 SNOMEDCT_US_2016_03_01:187646004 SNOMEDCT_US_2016_03_01:363375006 SNOMEDCT_US_2016_03_01:363376007 SNOMEDCT_US_2016_03_01:363377003 SNOMEDCT_US_2016_03_01:371974006 SNOMEDCT_US_2016_03_01:93687001 SNOMEDCT_US_2016_03_01:93773005 SNOMEDCT_US_2016_03_01:93848003 SNOMEDCT_US_2016_03_01:93868009 SNOMEDCT_US_2016_03_01:94100005 SNOMEDCT_US_2016_03_01:94101009 SNOMEDCT_US_2016_03_01:94134006 UMLS_CUI:C0153349 UMLS_CUI:C0153350 UMLS_CUI:C0153351 UMLS_CUI:C0153356 UMLS_CUI:C0474963 UMLS_CUI:C0496755 UMLS_CUI:C0684333 Tongue neoplasm malignant stage Unspecified malignant neoplasm of anterior 2/3 of tongue unspecified (disorder) malignant neoplasm of anterior two-thirds of tongue, part unspecified malignant neoplasm of base of tongue malignant neoplasm of border of tongue malignant neoplasm of dorsal surface of tongue malignant neoplasm of dorsal tongue NOS malignant neoplasm of dorsum of tongue NOS (disorder) malignant neoplasm of fixed part of tongue NOS malignant neoplasm of fixed part of tongue NOS (disorder) malignant neoplasm of junctional zone of tongue malignant neoplasm of lingual tonsil malignant neoplasm of mobile part of tongue NOS malignant neoplasm of other sites of tongue malignant neoplasm of other sites of tongue (disorder) malignant neoplasm of tip and lateral border of tongue malignant neoplasm of tip and/or lateral border of tongue malignant neoplasm of tongue malignant neoplasm of tongue NOS malignant neoplasm of tongue NOS (disorder) malignant neoplasm of tongue, NOS malignant neoplasm of tongue, tip and lateral border (disorder) malignant neoplasm of ventral surface of tongue malignant neoplasm of ventral tongue surface NOS (disorder) malignant tumor of Posterior Tongue malignant tumor of anterior two-thirds of tongue (disorder) malignant tumor of base of tongue (disorder) malignant tumor of lingual tonsil malignant tumor of lingual tonsil (disorder) malignant tumor of mobile part of tongue malignant tumor of tongue (disorder) disease_ontology DOID:8649 tongue cancer DOID:865 A vascular disease that is characterized by inflammation of the blood vessels. MESH:D014657 NCI:C26912 SNOMEDCT_US_2016_03_01:195375002 SNOMEDCT_US_2016_03_01:266325003 SNOMEDCT_US_2016_03_01:31996006 SNOMEDCT_US_2016_03_01:393589007 UMLS_CUI:C0042384 Angiitis disease_ontology DOID:865 vasculitis DOID:8659 A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters. DOID:8658 DOID:8693 DOID:9243 ICD10CM:B01 ICD10CM:B01.9 ICD9CM:052 MESH:D002644 NCI:C97132 SNOMEDCT_US_2016_03_01:154325003 SNOMEDCT_US_2016_03_01:186508005 SNOMEDCT_US_2016_03_01:38907003 UMLS_CUI:C0008049 varicella disease_ontology DOID:8659 chickenpox DOID:866 A vascular disease that is located_in a vein. ICD10CM:I82 ICD9CM:453 SNOMEDCT_US_2016_03_01:195435006 UMLS_CUI:C0155774 disease_ontology DOID:866 vein disease DOID:8670 A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health. ICD10CM:F50 ICD10CM:F50.9 ICD9CM:307.50 NCI:C89332 SNOMEDCT_US_2016_03_01:192444003 SNOMEDCT_US_2016_03_01:192452000 SNOMEDCT_US_2016_03_01:72366004 UMLS_CUI:C0013473 disease_ontology DOID:8670 eating disorder DOID:8681 ICD9CM:357.3 MESH:D020364 NCI:C3981 SNOMEDCT_US_2016_03_01:21361000119109 SNOMEDCT_US_2016_03_01:77659000 UMLS_CUI:C0270932 disease_ontology DOID:8681 paraneoplastic polyneuropathy DOID:8689 An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image. ICD10CM:F50.0 ICD10CM:F50.00 ICD9CM:307.1 MESH:D000856 NCI:C34387 SNOMEDCT_US_2016_03_01:154926005 SNOMEDCT_US_2016_03_01:192445002 SNOMEDCT_US_2016_03_01:56882008 UMLS_CUI:C0003125 disease_ontology DOID:8689 anorexia nervosa DOID:869 A keratosis characterized_by keratinizing squamous epithelium located_in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction. ICD10CM:H71.9 ICD10CM:H71.90 ICD9CM:385.30 MESH:D002781 NCI:C2944 SNOMEDCT_US_2016_03_01:155244001 SNOMEDCT_US_2016_03_01:194338004 SNOMEDCT_US_2016_03_01:267766007 SNOMEDCT_US_2016_03_01:363668000 SNOMEDCT_US_2016_03_01:575006 UMLS_CUI:C0008373 disease_ontology DOID:869 cholesteatoma DOID:8692 A leukemia that is located_in myeloid tissue. DOID:8878 DOID:8879 DOID:8910 DOID:9066 DOID:9126 ICD10CM:C92 ICD10CM:C92.9 ICD10CM:C92.90 ICD9CM:205 ICD9CM:205.9 MESH:D007951 NCI:C3172 SNOMEDCT_US_2016_03_01:128934006 SNOMEDCT_US_2016_03_01:154587007 SNOMEDCT_US_2016_03_01:188732008 SNOMEDCT_US_2016_03_01:188743000 SNOMEDCT_US_2016_03_01:190047005 SNOMEDCT_US_2016_03_01:269631008 SNOMEDCT_US_2016_03_01:324170002 SNOMEDCT_US_2016_03_01:37810007 SNOMEDCT_US_2016_03_01:94717009 UMLS_CUI:C0023470 Non-Lymphocytic Leukemia leukemia myelogenous myeloid granulocytic leukemia disease_ontology DOID:8692 myeloid leukemia DOID:870 A nervous system disease that is located_in nerves or nerve cells. ICD10CM:G62.9 NCI:C4731 SNOMEDCT_US_2016_03_01:193167000 SNOMEDCT_US_2016_03_01:264554005 SNOMEDCT_US_2016_03_01:277317008 SNOMEDCT_US_2016_03_01:277878001 SNOMEDCT_US_2016_03_01:386033004 SNOMEDCT_US_2016_03_01:42658009 UMLS_CUI:C0442874 peripheral neuropathy disease_ontology DOID:870 neuropathy DOID:8712 DOID:14750 DOID:8711 DOID:9137 ICD10CM:Q85.00 ICD10CM:Q85.01 ICD10CM:Q85.02 ICD9CM:237.7 ICD9CM:237.70 ICD9CM:237.71 ICD9CM:237.72 MESH:C537392 MESH:D009456 MESH:D016518 MESH:D017253 NCI:C3273 NCI:C3274 NCI:C6727 OMIM:101000 OMIM:162200 OMIM:162210 OMIM:162260 OMIM:162270 ORDO:636 ORDO:637 ORDO:93921 SNOMEDCT_US_2016_03_01:154642000 SNOMEDCT_US_2016_03_01:19133005 SNOMEDCT_US_2016_03_01:700060008 SNOMEDCT_US_2016_03_01:700061007 SNOMEDCT_US_2016_03_01:81669005 SNOMEDCT_US_2016_03_01:92503002 SNOMEDCT_US_2016_03_01:92824003 UMLS_CUI:C0027831 UMLS_CUI:C0027832 UMLS_CUI:C0162678 UMLS_CUI:C0220695 Acoustic neurofibromatosis Neurofibromatosis 1 Recklinghausen's neurofibromatosis central Neurofibromatosis neurofibromatosis type 1 neurofibromatosis type 2 neurofibromatosis type 4 neurofibromatosis type IV peripheral Neurofibromatosis type IV neurofibromatosis of riccardi von Reklinghausen disease disease_ontology DOID:8712 Xref MGI. OMIM mapping confirmed by DO. [SN]. neurofibromatosis DOID:8717 Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure. DOID:8808 DOID:9002 DOID:9029 DOID:9129 ICD10CM:L89 ICD10CM:L89.9 ICD9CM:707.0 ICD9CM:707.00 MESH:D003668 NCI:C50706 SNOMEDCT_US_2016_03_01:142668003 SNOMEDCT_US_2016_03_01:156424003 SNOMEDCT_US_2016_03_01:165258002 SNOMEDCT_US_2016_03_01:201248003 SNOMEDCT_US_2016_03_01:28103007 SNOMEDCT_US_2016_03_01:399912005 SNOMEDCT_US_2016_03_01:400192002 SNOMEDCT_US_2016_03_01:418172001 SNOMEDCT_US_2016_03_01:420226006 SNOMEDCT_US_2016_03_01:90144002 UMLS_CUI:C0011127 Decubitus (pressure) ulcer Decubitus ulcer Decubitus ulcer any site Decubitus ulcer, elbow Decubitus ulcer, lower back Decubitus ulcer, other site Decubitus ulcer, upper back pressure sores pressure ulcer disease_ontology bedsore DOID:8717 decubitus ulcer DOID:8719 A carcinoma that is an early development defined by the absence of invasion of surrounding tissues. DOID:8793 DOID:8821 ICD10CM:D09.9 ICD9CM:230-234.99 ICD9CM:234.9 MESH:D002278 NCI:C2917 SNOMEDCT_US_2016_03_01:109355002 SNOMEDCT_US_2016_03_01:154635000 SNOMEDCT_US_2016_03_01:154640008 SNOMEDCT_US_2016_03_01:189208007 SNOMEDCT_US_2016_03_01:189359006 SNOMEDCT_US_2016_03_01:189548003 SNOMEDCT_US_2016_03_01:271528002 SNOMEDCT_US_2016_03_01:399919001 SNOMEDCT_US_2016_03_01:68956006 UMLS_CUI:C0007099 disease_ontology DOID:8719 in situ carcinoma DOID:8725 A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain. DOID:13915 ICD10CM:F01 ICD10CM:F01.5 ICD9CM:290.4 MESH:D015140 MESH:D015161 NCI:C34522 NCI:C34525 SNOMEDCT_US_2016_03_01:154850006 SNOMEDCT_US_2016_03_01:191462009 SNOMEDCT_US_2016_03_01:192165000 SNOMEDCT_US_2016_03_01:192167008 SNOMEDCT_US_2016_03_01:192171006 SNOMEDCT_US_2016_03_01:268613002 SNOMEDCT_US_2016_03_01:429998004 SNOMEDCT_US_2016_03_01:56267009 UMLS_CUI:C0011263 UMLS_CUI:C0011269 Multi Infarct Dementia multifocal dementia disease_ontology DOID:8725 vascular dementia DOID:8736 A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk. ICD10CM:B03 ICD9CM:050 ICD9CM:050.9 MESH:D012899 NCI:C35027 SNOMEDCT_US_2016_03_01:154344005 SNOMEDCT_US_2016_03_01:186505008 SNOMEDCT_US_2016_03_01:266193008 SNOMEDCT_US_2016_03_01:47452006 SNOMEDCT_US_2016_03_01:67924001 UMLS_CUI:C0037354 Ordinary smallpox disease_ontology DOID:8736 smallpox DOID:874 A pneumonia involving inflammation of the lungs caused by bacteria. DOID:13815 ICD10CM:J15.9 ICD9CM:482.9 MESH:D018410 NCI:C26704 SNOMEDCT_US_2016_03_01:155553007 SNOMEDCT_US_2016_03_01:195891009 SNOMEDCT_US_2016_03_01:195892002 SNOMEDCT_US_2016_03_01:53084003 UMLS_CUI:C0004626 Pneumonia due to other gram-negative bacteria gram-negative pneumonia disease_ontology DOID:874 bacterial pneumonia DOID:8778 An intestinal disease that involves inflammation located_in intestine. DOID:8784 DOID:8855 DOID:8942 EFO:0000384 ICD10CM:K50.1 ICD9CM:555.1 MESH:D003424 NCI:C35211 NCI:C37262 SNOMEDCT_US_2016_03_01:155762006 SNOMEDCT_US_2016_03_01:196981009 SNOMEDCT_US_2016_03_01:196982002 SNOMEDCT_US_2016_03_01:266446008 SNOMEDCT_US_2016_03_01:50440006 SNOMEDCT_US_2016_03_01:7620006 UMLS_CUI:C0156147 Crohn disease Crohn's disease of colon (disorder) Crohn's disease of large bowel Granulomatous Colitis Pediatric Crohn's disease disease_ontology DOID:8778 MESH:C536215 added from NeuroDevNet [WAK]. Crohn's disease DOID:8781 A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis. DOID:11765 DOID:1463 DOID:1464 DOID:8780 DOID:8816 DOID:8909 DOID:9106 DOID:9116 DOID:9162 DOID:9179 ICD10CM:B06 ICD10CM:B06.9 ICD9CM:056 MESH:D012409 NCI:C85051 SNOMEDCT_US_2016_03_01:154343004 SNOMEDCT_US_2016_03_01:266192003 SNOMEDCT_US_2016_03_01:36653000 UMLS_CUI:C0035920 german measles disease_ontology DOID:8781 rubella DOID:8791 ICD10CM:D05 ICD10CM:D05.9 ICD9CM:233.0 NCI:C3641 SNOMEDCT_US_2016_03_01:154636004 SNOMEDCT_US_2016_03_01:189336000 UMLS_CUI:C0154084 Non-Infiltrating carcinoma of breast carcinoma in situ of breast disease_ontology DOID:8791 breast carcinoma in situ DOID:8805 ICD10CM:I20.0 ICD9CM:411.1 MESH:D000789 NCI:C66911 SNOMEDCT_US_2016_03_01:155308009 SNOMEDCT_US_2016_03_01:155313008 SNOMEDCT_US_2016_03_01:155314002 SNOMEDCT_US_2016_03_01:194814006 SNOMEDCT_US_2016_03_01:194816008 SNOMEDCT_US_2016_03_01:194817004 SNOMEDCT_US_2016_03_01:194819001 SNOMEDCT_US_2016_03_01:233818002 SNOMEDCT_US_2016_03_01:233820004 SNOMEDCT_US_2016_03_01:25106000 SNOMEDCT_US_2016_03_01:4557003 SNOMEDCT_US_2016_03_01:59021001 SNOMEDCT_US_2016_03_01:64333001 UMLS_CUI:C0002965 (Angina: [crescendo] or [unstable] or [at rest]) or (preinfarction syndrome) or (impending infarction) Angina at rest Anginal chest pain at rest Impending infarction (disorder) Preinfarction angina Preinfarction angina (disorder) Unstable angina Worsening angina disease_ontology DOID:8805 intermediate coronary syndrome DOID:883 A parasitic infectious disease that occurs when part of the body is infested with parasitic worms such as cestodes, nematodes and trematodes. DOID:10693 DOID:3563 DOID:458 DOID:932 ICD10CM:B65-B83 ICD10CM:B83.9 ICD9CM:120-129.99 ICD9CM:128.9 MESH:D006373 NCI:C84751 SNOMEDCT_US_2016_03_01:154410004 SNOMEDCT_US_2016_03_01:187189004 SNOMEDCT_US_2016_03_01:187518006 SNOMEDCT_US_2016_03_01:187542005 SNOMEDCT_US_2016_03_01:266219000 SNOMEDCT_US_2016_03_01:27601005 UMLS_CUI:C0018889 helminth infection helminthiasis helminthosis worm infection disease_ontology DOID:883 parasitic helminthiasis infectious disease DOID:8838 ICD10CM:C81.1 ICD9CM:201.5 NCI:C3518 SNOMEDCT_US_2016_03_01:118608000 SNOMEDCT_US_2016_03_01:134178004 SNOMEDCT_US_2016_03_01:188564003 SNOMEDCT_US_2016_03_01:188573006 SNOMEDCT_US_2016_03_01:52248008 UMLS_CUI:C0152268 Classical Hodgkin lymphoma, nodular sclerosis Hodgkin lymphoma, nodular sclerosis Hodgkin's disease nodular sclerosis NOS Hodgkin's disease, nodular sclerosis (disorder) Hodgkin's disease, nodular sclerosis NOS (disorder) Hodgkin's disease, nodular sclerosis NOS (morphologic abnormality) Hodgkin's disease, nodular sclerosis of unspecified site (disorder) NSHL disease_ontology Hodgkin's disease, nodular sclerosis DOID:8838 Hodgkin's lymphoma, nodular sclerosis DOID:885 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa. ICD10CM:B66.3 ICD9CM:121.3 MESH:D005211 SNOMEDCT_US_2016_03_01:111922007 SNOMEDCT_US_2016_03_01:187125007 UMLS_CUI:C0015652 Fasciola hepatica infection (disorder) Infection by Fasciola (disorder) Liver flukes NOS Liver flukes NOS (disorder) Sheep liver fluke infection disease_ontology DOID:885 fascioliasis DOID:8850 An oral cavity cancer that is located_in the salivary gland. DOID:8873 DOID:9148 ICD10CM:C08 ICD9CM:142.8 SNOMEDCT_US_2016_03_01:187648003 UMLS_CUI:C0153362 malignant neoplasm of major salivary gland malignant neoplasm of salivary gland malignant neoplasm of salivary gland duct malignant tumor of the Major Salivary gland malignant tumor of the Salivary gland disease_ontology DOID:8850 salivary gland cancer DOID:8857 ICD10CM:L93 ICD10CM:L93.0 ICD9CM:695.4 NCI:C27153 SNOMEDCT_US_2016_03_01:200936003 SNOMEDCT_US_2016_03_01:200944003 UMLS_CUI:C0409974 lupus disease_ontology DOID:8857 lupus erythematosus DOID:8867 A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center. ICD10CM:B08.1 ICD9CM:078.0 MESH:D008976 SNOMEDCT_US_2016_03_01:154360009 SNOMEDCT_US_2016_03_01:40070004 UMLS_CUI:C0026393 disease_ontology DOID:8867 molluscum contagiosum DOID:8869 A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis). EFO:0004256 ICD10CM:G36.0 ICD9CM:341.0 MESH:D009471 NCI:C84934 SNOMEDCT_US_2016_03_01:25044007 UMLS_CUI:C0027873 Devic's disease Devic's syndrome disease_ontology DOID:8869 neuromyelitis optica DOID:8892 ICD10CM:L42 ICD9CM:696.3 MESH:D017515 NCI:C26855 SNOMEDCT_US_2016_03_01:156373006 SNOMEDCT_US_2016_03_01:77252004 UMLS_CUI:C0032026 Pityriasis Rosea Pityriasis circinata Pityriasis rosea (disorder) disease_ontology DOID:8892 pityriasis rosea DOID:8893 EFO:0000676 ICD10CM:L40 ICD10CM:L40.9 MESH:D011565 NCI:C3346 OMIM:177900 OMIM:601454 OMIM:602723 OMIM:603935 OMIM:604316 OMIM:605364 OMIM:605606 OMIM:607857 OMIM:610707 OMIM:612410 OMIM:612599 OMIM:612950 OMIM:614070 SNOMEDCT_US_2016_03_01:156369008 SNOMEDCT_US_2016_03_01:156371008 SNOMEDCT_US_2016_03_01:200961000 SNOMEDCT_US_2016_03_01:200978009 SNOMEDCT_US_2016_03_01:267851002 SNOMEDCT_US_2016_03_01:9014002 UMLS_CUI:C0033860 disease_ontology DOID:8893 Xref MGI. Update outdated UMLS CUI from C00295134 to C0033860. psoriasis DOID:8913 A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source. ICD10CM:B35 ICD10CM:B35.9 ICD9CM:110 ICD9CM:110.9 NCI:C26745 SNOMEDCT_US_2016_03_01:154394006 SNOMEDCT_US_2016_03_01:186984003 SNOMEDCT_US_2016_03_01:186998006 SNOMEDCT_US_2016_03_01:187474000 SNOMEDCT_US_2016_03_01:266214005 SNOMEDCT_US_2016_03_01:47382004 UMLS_CUI:C0011636 disease_ontology DOID:8913 dermatophytosis DOID:8927 A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information. DOID:2847 ICD10CM:F81.9 MESH:D007859 NCI:C89334 SNOMEDCT_US_2016_03_01:154973004 SNOMEDCT_US_2016_03_01:154974005 SNOMEDCT_US_2016_03_01:1855002 SNOMEDCT_US_2016_03_01:192531005 SNOMEDCT_US_2016_03_01:247576004 SNOMEDCT_US_2016_03_01:367332004 SNOMEDCT_US_2016_03_01:389991004 UMLS_CUI:C0023186 UMLS_CUI:C0751265 Academic skill disorder learning disorder disease_ontology DOID:8927 learning disability DOID:8929 DOID:9048 DOID:9083 ICD10CM:K29.4 ICD9CM:535.1 ICD9CM:535.11 MESH:D005757 NCI:C7405 SNOMEDCT_US_2016_03_01:155713006 SNOMEDCT_US_2016_03_01:196733008 SNOMEDCT_US_2016_03_01:270533009 SNOMEDCT_US_2016_03_01:84568007 UMLS_CUI:C0017154 UMLS_CUI:C0156073 gastric atrophy disease_ontology DOID:8929 atrophic gastritis DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 SNOMEDCT_US_2016_03_01:141196007 SNOMEDCT_US_2016_03_01:154678005 SNOMEDCT_US_2016_03_01:155107006 SNOMEDCT_US_2016_03_01:163997001 SNOMEDCT_US_2016_03_01:193353002 SNOMEDCT_US_2016_03_01:267471001 SNOMEDCT_US_2016_03_01:309595004 SNOMEDCT_US_2016_03_01:4855003 UMLS_CUI:C0011884 Retinal abnormality - diabetes-related disease_ontology DOID:8947 diabetic retinopathy DOID:8955 An aplastic anemia where the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). ICD10CM:D64.3 ICD9CM:285.0 MESH:D000756 NCI:C36078 SNOMEDCT_US_2016_03_01:154810008 SNOMEDCT_US_2016_03_01:191263002 SNOMEDCT_US_2016_03_01:41841004 UMLS_CUI:C0002896 ANEMIA SIDEROBLASTIC Anemia, hypochromic with iron loading disease_ontology DOID:8955 sideroblastic anemia DOID:8956 A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face. ICD10CM:B08.010 ICD9CM:051.01 MESH:D015605 SNOMEDCT_US_2016_03_01:154344005 SNOMEDCT_US_2016_03_01:266193008 SNOMEDCT_US_2016_03_01:70090004 UMLS_CUI:C0010232 yaba disease_ontology DOID:8956 cowpox DOID:896 An inherited metabolic disorder that involves metabolic disturbances in the processing or distribution of dietary minerals. MESH:D008664 UMLS_CUI:C0025534 inborn metal metabolism disorder disease_ontology DOID:896 metal metabolism disorder DOID:898 An autosomal dominant disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium. ICD10CM:Q61.3 ICD9CM:753.12 MESH:D007690 NCI:C75464 OMIM:PS173900 ORDO:730 SNOMEDCT_US_2016_03_01:156973002 SNOMEDCT_US_2016_03_01:204954005 SNOMEDCT_US_2016_03_01:204955006 SNOMEDCT_US_2016_03_01:204956007 SNOMEDCT_US_2016_03_01:268233005 SNOMEDCT_US_2016_03_01:268332003 SNOMEDCT_US_2016_03_01:82525005 UMLS_CUI:C0022680 Congenital biliary ectasias POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 disease_ontology DOID:898 Xref MGI. OMIM mapping confirmed by DO. [SN]. Updating outdated UMLS CUI. Removing Caroli disease as a synonym as this is a distinct disease. autosomal dominant polycystic kidney disease DOID:8986 A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work. DOID:8985 EFO:0000614 ICD10CM:G47.41 ICD10CM:G47.419 ICD9CM:347.0 MESH:D009290 NCI:C84489 OMIM:161400 OMIM:605841 OMIM:609039 OMIM:612417 OMIM:612851 OMIM:614223 OMIM:614250 ORDO:2073 SNOMEDCT_US_2016_03_01:155059003 SNOMEDCT_US_2016_03_01:267702006 SNOMEDCT_US_2016_03_01:60380001 UMLS_CUI:C0027404 Narcolepsy, without cataplexy paroxysmal sleep disease_ontology DOID:8986 Xref MGI. narcolepsy DOID:8997 ICD10CM:D45 ICD9CM:238.4 MESH:D011087 NCI:C3336 OMIM:263300 SNOMEDCT_US_2016_03_01:109992005 SNOMEDCT_US_2016_03_01:128841001 SNOMEDCT_US_2016_03_01:134182002 SNOMEDCT_US_2016_03_01:154644004 SNOMEDCT_US_2016_03_01:269652000 SNOMEDCT_US_2016_03_01:278190000 SNOMEDCT_US_2016_03_01:31569001 UMLS_CUI:C0032463 Osler-Vaquez syndrome Polycythaemia rubra vera Proliferative polycythaemia disease_ontology DOID:8997 OMIM mapping confirmed by DO. [SN]. polycythemia vera DOID:90 A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc. DOID:7943 EFO:0004994 NCI:C27156 SNOMEDCT_US_2016_03_01:156633005 UMLS_CUI:C0410606 cervical disc degenerative disease intervertebral disc degeneration lumbar disc degeneration vertebral disc disease disease_ontology DOID:90 degenerative disc disease DOID:900 ICD10CM:K76.81 ICD9CM:573.5 MESH:D020065 SNOMEDCT_US_2016_03_01:371067004 UMLS_CUI:C0600452 Hepatopulmonary syndrome (disorder) disease_ontology DOID:900 hepatopulmonary syndrome DOID:9007 A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation. ICD9CM:798.0 MESH:D013398 NCI:C85173 OMIM:272120 SNOMEDCT_US_2016_03_01:158718001 SNOMEDCT_US_2016_03_01:207534005 SNOMEDCT_US_2016_03_01:207535006 SNOMEDCT_US_2016_03_01:207536007 SNOMEDCT_US_2016_03_01:207538008 SNOMEDCT_US_2016_03_01:207671002 SNOMEDCT_US_2016_03_01:51178009 UMLS_CUI:C0038644 Cot death Cot death (context-dependent category) Crib death (context-dependent category) SIDS Sudden death of nonspecific cause in infancy Sudden infant death syndrome (context-dependent category) Sudden infant death syndrome (finding) Sudden infant death syndrome NOS (context-dependent category) disease_ontology DOID:9007 sudden infant death syndrome DOID:905 A peroxisomal disease that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes. ICD10CM:E71.510 MESH:D015211 NCI:C85239 OMIM:214100 ORDO:912 SNOMEDCT_US_2016_03_01:88469006 UMLS_CUI:C0043459 cerebrohepatorenal syndrome congenital iron overload peroxisome biogenesis disorder disease_ontology DOID:905 OMIM mapping confirmed by DO. [LS]. OMIM mapping confirmed by DO. [SN]. Zellweger syndrome DOID:906 An inherited metabolic disorder that involves peroxisome malfunction. ICD10CM:E71.5 ICD10CM:E71.50 ICD9CM:277.86 MESH:D018901 NCI:C85005 SNOMEDCT_US_2016_03_01:238059005 UMLS_CUI:C0282528 peroxisomal disorder disease_ontology DOID:906 peroxisomal disease DOID:9060 A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales. ICD10CM:B36.0 ICD9CM:111.0 MESH:D014010 NCI:C112833 NCI:C82981 SNOMEDCT_US_2016_03_01:154395007 SNOMEDCT_US_2016_03_01:56454009 UMLS_CUI:C0040262 Infection by Pityrosporum furfur Pityriasis versicolor (disorder) disease_ontology DOID:9060 pityriasis versicolor DOID:9063 A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability. ICD10CM:L00 ICD9CM:695.81 MESH:D013206 NCI:C85077 SNOMEDCT_US_2016_03_01:200946001 SNOMEDCT_US_2016_03_01:367537006 SNOMEDCT_US_2016_03_01:87758007 UMLS_CUI:C0038165 Dermatitis exfoliativa neonatorum Pemphigus neonatorum Ritter disease Scalded skin syndrome Staphylococcal scalded skin syndrome (disorder) Toxic epidermal necrolysis, subcorneal type (disorder) disease_ontology DOID:9063 Ritter's disease DOID:9065 A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus Leishmania, which is transmitted by the bite of sand fly (subfamily Phlebotominae). DOID:9136 ICD10CM:B55 ICD10CM:B55.9 ICD9CM:085 ICD9CM:085.9 MESH:D007896 NCI:C34767 SNOMEDCT_US_2016_03_01:154377009 SNOMEDCT_US_2016_03_01:186811002 SNOMEDCT_US_2016_03_01:187511000 SNOMEDCT_US_2016_03_01:266206004 SNOMEDCT_US_2016_03_01:80612004 UMLS_CUI:C0023281 disease_ontology Post Kala-Azar Dermal Leishmaniasis Post-kala-azar dermal leishmaniasis post-kala-azar dermal infectious disease by leishmaniasis DOID:9065 leishmaniasis DOID:9074 A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. EFO:0002690 ICD10CM:M32 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:601744 OMIM:605218 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:610927 OMIM:612251 OMIM:612253 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 SNOMEDCT_US_2016_03_01:156450004 SNOMEDCT_US_2016_03_01:201435004 SNOMEDCT_US_2016_03_01:201439005 SNOMEDCT_US_2016_03_01:55464009 UMLS_CUI:C0024141 Lupus Erythematosus, systemic SLE - Lupus Erythematosus, systemic disseminated lupus erythematosus disease_ontology DOID:9074 Xref MGI. systemic lupus erythematosus DOID:9080 ICD10CM:C88.0 ICD9CM:273.3 MESH:D008258 NCI:C115212 NCI:C80307 SNOMEDCT_US_2016_03_01:109981009 SNOMEDCT_US_2016_03_01:154750002 SNOMEDCT_US_2016_03_01:190014001 SNOMEDCT_US_2016_03_01:190817009 SNOMEDCT_US_2016_03_01:190818004 SNOMEDCT_US_2016_03_01:190821002 SNOMEDCT_US_2016_03_01:267503004 SNOMEDCT_US_2016_03_01:35562000 UMLS_CUI:C0024419 UMLS_CUI:C2936755 primary macroglobulinemia disease_ontology DOID:9080 macroglobulinemia DOID:9091 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement. ICD10CM:G47.52 ICD9CM:327.42 MESH:D020187 SNOMEDCT_US_2016_03_01:415238003 UMLS_CUI:C0751772 Rapid eye movement sleep behavior disorder disease_ontology DOID:9091 REM sleep behavior disorder DOID:9111 A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions. DOID:13553 DOID:9110 DOID:9122 DOID:9167 ICD10CM:B55.1 MESH:D016773 NCI:C34768 SNOMEDCT_US_2016_03_01:240637006 UMLS_CUI:C0023283 Asian Desert Cutaneous Leishmaniasis Leproid leishmaniasis diffuse cutaneous leishmaniasis disease_ontology DOID:9111 cutaneous leishmaniasis DOID:9119 A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. DOID:9118 DOID:9171 ICD10CM:C92.0 ICD10CM:C92.00 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C27753 NCI:C3171 OMIM:601626 SNOMEDCT_US_2016_03_01:154591002 SNOMEDCT_US_2016_03_01:17788007 SNOMEDCT_US_2016_03_01:277600006 SNOMEDCT_US_2016_03_01:413443009 SNOMEDCT_US_2016_03_01:91861009 UMLS_CUI:C0023467 AML - acute Myeloid Leukemia Leukemia, Myelocytic, acute acute myeloblastic leukemia acute myelogenous leukemia disease_ontology DOID:9119 OMIM mapping confirmed by DO. [SN]. acute myeloid leukemia DOID:9120 An acquired metabolic disease that involves abnormal deposited of amyloid proteins in organs and/or tissues. ICD10CM:E85 ICD10CM:E85.9 ICD9CM:277.3 ICD9CM:277.30 MESH:D000686 NCI:C2868 SNOMEDCT_US_2016_03_01:154769007 SNOMEDCT_US_2016_03_01:17602002 SNOMEDCT_US_2016_03_01:190931005 UMLS_CUI:C0002726 amyloid disease disease_ontology DOID:9120 amyloidosis DOID:9146 A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver. ICD10CM:B55.0 ICD9CM:085.0 MESH:D007898 NCI:C34771 OMIM:608207 OMIM:611381 OMIM:611382 ORDO:507 SNOMEDCT_US_2016_03_01:186803007 SNOMEDCT_US_2016_03_01:48115004 UMLS_CUI:C0023290 Infection by visceral leishmaniasis Kala-Azar disease_ontology DOID:9146 Xref MGI. visceral leishmaniasis DOID:9149 ICD10CM:C05.0 ICD9CM:145.2 NCI:C3528 SNOMEDCT_US_2016_03_01:363387004 SNOMEDCT_US_2016_03_01:93822006 UMLS_CUI:C0153375 Hard Palate malignant neoplasm of hard palate malignant tumor of hard palate (disorder) malignant tumor of the Hard Palate malignant tumour of hard palate disease_ontology DOID:9149 hard palate cancer DOID:9155 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa. ICD10CM:B55.2 ICD9CM:085.5 MESH:D007897 SNOMEDCT_US_2016_03_01:186810001 SNOMEDCT_US_2016_03_01:39625001 SNOMEDCT_US_2016_03_01:403135004 UMLS_CUI:C1328252 American Cutaneous Leishmaniasis American cutaneous leishmaniasis American mucocutaneous leishmaniasis American mucocutaneous leishmaniasis (disorder) Cutaneous leishmaniasis, American Mucocutaneous leishmaniasis, (American) Mucocutaneous leishmaniasis, American New World cutaneous leishmaniasis disease_ontology DOID:9155 mucocutaneous leishmaniasis DOID:9159 A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis. ICD10CM:A48.0 ICD9CM:040.0 MESH:D005738 SNOMEDCT_US_2016_03_01:186407003 SNOMEDCT_US_2016_03_01:186413007 SNOMEDCT_US_2016_03_01:276198000 SNOMEDCT_US_2016_03_01:80466000 UMLS_CUI:C0017105 Gas bacillus infection Gas gangrene Myonecrosis disease_ontology DOID:9159 gas gangrene DOID:916 DOID:692 NCI:C7103 NCI:C7106 UMLS_CUI:C1333419 UMLS_CUI:C1333976 epithelial hepatic and intrahepatic bile duct neoplasm disease_ontology DOID:916 liver neoplasm DOID:9164 An esophageal disease that is characterized by an inability of the esophagus to move food toward the stomach resulting from the lower esophogeal sphincter not fully relaxing during swallowing. ICD10CM:K22.0 ICD9CM:530.0 MESH:D004931 NCI:C84699 OMIM:200400 SNOMEDCT_US_2016_03_01:155672003 SNOMEDCT_US_2016_03_01:17460002 SNOMEDCT_US_2016_03_01:45564002 UMLS_CUI:C0014848 Lack of reflex relaxation of lower oesophageal sphincter achalasia of cardia achalasia of esophagus cardiospasm esophageal achalasia hypertensive lower esophageal sphincter disease_ontology DOID:9164 achalasia DOID:917 NCI:C5753 UMLS_CUI:C1333968 leiomyoma of the Liver disease_ontology DOID:917 liver leiomyoma DOID:9173 ICD10CM:C08.0 ICD9CM:142.1 NCI:C3526 SNOMEDCT_US_2016_03_01:363380002 SNOMEDCT_US_2016_03_01:94077005 UMLS_CUI:C0153360 malignant neoplasm of submaxillary gland malignant tumor of submandibular gland (disorder) malignant tumor of the Submandibular gland disease_ontology DOID:9173 submandibular gland cancer DOID:9181 A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs. DOID:11901 DOID:11904 ICD10CM:A06 ICD10CM:A06.9 ICD9CM:006 ICD9CM:006.9 MESH:D000562 NCI:C84551 SNOMEDCT_US_2016_03_01:105637008 SNOMEDCT_US_2016_03_01:111909004 SNOMEDCT_US_2016_03_01:111910009 SNOMEDCT_US_2016_03_01:154274000 SNOMEDCT_US_2016_03_01:186122001 SNOMEDCT_US_2016_03_01:187278004 SNOMEDCT_US_2016_03_01:282008000 SNOMEDCT_US_2016_03_01:387754006 SNOMEDCT_US_2016_03_01:388759003 UMLS_CUI:C0002438 amoebiasis entamoebiasis disease_ontology chronic intestinal amebiasis DOID:9181 amebiasis DOID:9191 ICD9CM:362.07 SNOMEDCT_US_2016_03_01:312912001 UMLS_CUI:C0730285 disease_ontology DOID:9191 diabetic macular edema DOID:92 A communication disorder that involves difficulty with the act of speech production. MESH:D013064 NCI:C5041 UMLS_CUI:C0037822 disease_ontology DOID:92 speech disorder DOID:9201 A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes. ICD10CM:L43 ICD10CM:L43.9 ICD9CM:697.0 MESH:D008010 NCI:C3189 SNOMEDCT_US_2016_03_01:156377007 SNOMEDCT_US_2016_03_01:201004002 SNOMEDCT_US_2016_03_01:4776004 UMLS_CUI:C0023646 Lichen, ruber planus lichen ruber planus disease_ontology DOID:9201 lichen planus DOID:9206 EFO:0000280 ICD10CM:K22.7 ICD10CM:K22.70 ICD9CM:530.85 MESH:D001471 NCI:C2891 OMIM:614266 SNOMEDCT_US_2016_03_01:155679007 SNOMEDCT_US_2016_03_01:196603007 SNOMEDCT_US_2016_03_01:196609006 SNOMEDCT_US_2016_03_01:235597001 SNOMEDCT_US_2016_03_01:302914006 SNOMEDCT_US_2016_03_01:76355008 UMLS_CUI:C0004763 (ulcerative esophagitis) or (Barrett's esophagus) Barrett esophagus Barrett's esophagus with esophagitis Barrett's oesophagus Barrett's ulcer of esophagus Barretts syndrome CLE disease_ontology DOID:9206 Barrett's esophagus DOID:9207 A sleep disorder that involves involuntary limb movement during sleep. ICD10CM:G47.61 ICD9CM:327.51 MESH:D020189 SNOMEDCT_US_2016_03_01:418763003 UMLS_CUI:C0751774 nocturnal myoclonus disease_ontology DOID:9207 periodic limb movement disorder DOID:9220 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing. ICD10CM:G47.31 ICD9CM:327.21 MESH:D020182 OMIM:107640 OMIM:207720 SNOMEDCT_US_2016_03_01:9741000119101 UMLS_CUI:C0751762 primary central sleep apnea disease_ontology central sleep apnea syndrome DOID:9220 Xref MGI. central sleep apnea DOID:9240 ICD10CM:I73.81 ICD9CM:443.82 MESH:D004916 NCI:C34593 SNOMEDCT_US_2016_03_01:238777005 SNOMEDCT_US_2016_03_01:37151006 UMLS_CUI:C0014804 disease_ontology DOID:9240 erythromelalgia DOID:9246 An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia. MESH:D028243 OMIM:105150 OMIM:117300 OMIM:176500 OMIM:605714 ORDO:85458 SNOMEDCT_US_2016_03_01:56453003 UMLS_CUI:C0268394 Hereditary cerebral haemorrhage with amyloidosis - Dutch type (disorder) dutch hereditary cerebral amyloid angiopathy disease_ontology DOID:9246 Xref MGI. OMIM mapping confirmed by DO. [SN]. cerebral amyloid angiopathy DOID:9248 MESH:D054975 NCI:C84987 OMIM:146510 SNOMEDCT_US_2016_03_01:56677004 UMLS_CUI:C0265220 Pallister-Hall syndrome (disorder) disease_ontology DOID:9248 OMIM mapping confirmed by DO. [SN]. Pallister-Hall syndrome DOID:9252 An inherited metabolic disorders which impair the synthesis and degradation of amino acids. ICD10CM:E72.9 ICD9CM:270 ICD9CM:270.9 MESH:D000592 NCI:C97090 SNOMEDCT_US_2016_03_01:154734005 SNOMEDCT_US_2016_03_01:190680002 SNOMEDCT_US_2016_03_01:190740001 SNOMEDCT_US_2016_03_01:267496003 SNOMEDCT_US_2016_03_01:42930003 SNOMEDCT_US_2016_03_01:44779003 UMLS_CUI:C0002514 inborn errors of amino acid metabolism disease_ontology DOID:9252 amino acid metabolic disorder DOID:9253 MESH:D046152 NCI:C3868 OMIM:606764 SNOMEDCT_US_2016_03_01:128755003 SNOMEDCT_US_2016_03_01:420120006 UMLS_CUI:C0238198 GANT GIST Stromal tumor of gastrointestinal tract disease_ontology DOID:9253 OMIM mapping confirmed by DO. [SN]. gastrointestinal stromal tumor DOID:9255 A basal ganglia disease characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language. MESH:C563003 OMIM:600274 OMIM:600795 ORDO:282 SNOMEDCT_US_2016_03_01:42369001 UMLS_CUI:C0520716 Wilhemsen-Lynch disease frontotemporal lobar degeneration multiple system tauopathy with presenile dementia pallidopontonigral degeneration disease_ontology DOID:9255 Xref MGI. OMIM mapping confirmed by DO. [SN]. frontotemporal dementia DOID:9256 A large intestine cancer that is located_in the colon and/or located_in the rectum. KEGG:05210 MESH:D015179 OMIM:114500 OMIM:608812 OMIM:611469 OMIM:612229 OMIM:612230 OMIM:612231 OMIM:612232 OMIM:612589 OMIM:612590 OMIM:612591 OMIM:612592 OMIM:615083 UMLS_CUI:C1527249 disease_ontology DOID:9256 Xref MGI. OMIM mapping confirmed by DO. [SN]. colorectal cancer DOID:9258 An autosomal disease characterized by varying degrees of deafness, minor defects in structures arising from the neural crest and pigmentation anomalies of the hair, the skin and/or the iris of both eyes. MESH:D014849 NCI:C75008 NCI:C85222 OMIM:148820 OMIM:193500 OMIM:193510 OMIM:277580 OMIM:600193 OMIM:606662 OMIM:608890 OMIM:611584 OMIM:613265 OMIM:613266 ORDO:3440 ORDO:894 ORDO:895 ORDO:896 SNOMEDCT_US_2016_03_01:47434006 UMLS_CUI:C0079661 UMLS_CUI:C1847800 UMLS_CUI:C3266898 Waardenburg Shah syndrome Waardenburg syndrome Waardenburg, types I and/or II Waardenburg-Klein syndrome van der Hoeve Halbertsona Waardenburg syndrome disease_ontology DOID:9258 Xref MGI. OMIM mapping confirmed by DO. [SN]. Waardenburg's syndrome DOID:9268 An amino acid metabolic disorder that involves abnormally high levels of the amino acid glycine in bodily fluids and tissues. ICD10CM:E72.51 MESH:D020158 NCI:C84937 OMIM:605899 SNOMEDCT_US_2016_03_01:237939006 UMLS_CUI:C0751748 Non-ketotic hyperglycinemia Non-ketotic hyperglycinemia (disorder) nonketotic hyperglycinemia disease_ontology DOID:9268 OMIM mapping confirmed by DO. [SN]. glycine encephalopathy DOID:9269 An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures. ICD10CM:E71.0 MESH:D008375 NCI:C34806 OMIM:246900 OMIM:248600 OMIM:615135 ORDO:511 SNOMEDCT_US_2016_03_01:27718001 UMLS_CUI:C0024776 Ketoacidaemia branched chain ketoaciduria disease_ontology dihydrolipoamide dehydrogenase deficiency DOID:9269 Xref MGI. OMIM mapping confirmed by DO. [SN]. maple syrup urine disease DOID:9274 An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood. ICD10CM:E72.3 MESH:D020167 NCI:C123433 OMIM:238700 OMIM:238710 ORDO:2203 SNOMEDCT_US_2016_03_01:58558003 UMLS_CUI:C0268553 disease_ontology DOID:9274 OMIM mapping confirmed by DO. [SN]. hyperlysinemia DOID:9275 An amino acid metabolic disorder that involves impaired break down of the amino acid tyrosine. ICD10CM:E70.21 MESH:D020176 NCI:C98640 SNOMEDCT_US_2016_03_01:190694001 UMLS_CUI:C0268483 disease_ontology DOID:9275 OMIM mapping submitted by NeuroDevNet. [LS]. tyrosinemia DOID:9279 An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood. MESH:D020138 NCI:C84770 SNOMEDCT_US_2016_03_01:419503008 UMLS_CUI:C0598608 disease_ontology DOID:9279 hyperhomocysteinemia DOID:9281 An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional. DOID:14455 ICD9CM:270.1 MESH:D010661 MESH:D017042 NCI:C81315 OMIM:261600 SNOMEDCT_US_2016_03_01:154735006 SNOMEDCT_US_2016_03_01:190687004 SNOMEDCT_US_2016_03_01:297225000 UMLS_CUI:C0031485 UMLS_CUI:C0085547 Følling's disease PKU maternal phenylketonuria phenylalaninemia disease_ontology DOID:9281 OMIM mapping confirmed by DO. [SN]. phenylketonuria DOID:9282 An eye disease that is characterized by elevated intraocular pressure in the absence of optic nerve damage or visual field loss. ICD10CM:H40.05 ICD9CM:365.04 MESH:D009798 NCI:C3285 SNOMEDCT_US_2016_03_01:155121008 SNOMEDCT_US_2016_03_01:193536008 SNOMEDCT_US_2016_03_01:267721003 SNOMEDCT_US_2016_03_01:4210003 UMLS_CUI:C0028840 disease_ontology DOID:9282 ocular hypertension DOID:9283 ICD10CM:H40.00 ICD9CM:365.00 SNOMEDCT_US_2016_03_01:193532005 SNOMEDCT_US_2016_03_01:359633007 SNOMEDCT_US_2016_03_01:47891005 UMLS_CUI:C0549470 Preglaucoma disease_ontology DOID:9283 borderline glaucoma DOID:9296 DOID:9333 EFO:0003959 ICD10CM:Q36 ICD10CM:Q36.9 ICD9CM:749.1 ICD9CM:749.10 ICD9CM:749.11 MESH:D002971 NCI:C87175 SNOMEDCT_US_2016_03_01:156941008 SNOMEDCT_US_2016_03_01:204606000 SNOMEDCT_US_2016_03_01:204609007 SNOMEDCT_US_2016_03_01:62696001 SNOMEDCT_US_2016_03_01:80281008 UMLS_CUI:C0008924 UMLS_CUI:C0158651 Labium leporinum cheiloschisis cleft lip, unilateral, complete complete unilateral cleft lip hare lip disease_ontology DOID:9296 cleft lip DOID:9297 ICD10CM:K13.0 ICD9CM:528.5 MESH:D008047 NCI:C26818 SNOMEDCT_US_2016_03_01:196563002 SNOMEDCT_US_2016_03_01:90678009 UMLS_CUI:C0023760 disease of lips disease_ontology DOID:9297 lip disease DOID:93 A communication disorder that involves the processing of linguistic information. ICD10CM:F80.9 MESH:D007806 NCI:C97155 SNOMEDCT_US_2016_03_01:62305002 UMLS_CUI:C0023015 disease_ontology DOID:93 language disorder DOID:930 An adnexa disease that is located_in the eye socket. ICD10CM:H05 ICD10CM:H05.9 ICD9CM:376 ICD9CM:376.9 MESH:D009916 SNOMEDCT_US_2016_03_01:11270005 SNOMEDCT_US_2016_03_01:155200004 SNOMEDCT_US_2016_03_01:194036005 SNOMEDCT_US_2016_03_01:267746003 UMLS_CUI:C0029182 disease_ontology DOID:930 orbital disease DOID:9307 ICD10CM:K62.3 ICD9CM:569.1 MESH:D012005 NCI:C34973 SNOMEDCT_US_2016_03_01:155802002 SNOMEDCT_US_2016_03_01:197212009 SNOMEDCT_US_2016_03_01:197214005 SNOMEDCT_US_2016_03_01:197215006 SNOMEDCT_US_2016_03_01:57773001 UMLS_CUI:C0034888 Procidentia, rectum disease_ontology DOID:9307 rectal prolapse DOID:9335 DOID:10750 DOID:10751 DOID:9482 ICD10CM:H53.42 ICD10CM:H53.43 ICD10CM:H53.45 ICD9CM:368.42 ICD9CM:368.43 ICD9CM:368.44 ICD9CM:368.45 SNOMEDCT_US_2016_03_01:193673000 SNOMEDCT_US_2016_03_01:33970004 UMLS_CUI:C0029657 UMLS_CUI:C0152192 UMLS_CUI:C0155011 UMLS_CUI:C0155012 Blind spot area scotoma Enlarged angioscotoma Enlarged blind spot Enlarged paracaecal scotoma Generalized visual field contraction or constriction Scotoma of blind spot area Sector or arcuate visual field defects disease_ontology DOID:9335 scotoma DOID:934 A disease by infectious agent that results_in infection, has_material_basis_in Viruses. DOID:1329 ICD10CM:A94 ICD10CM:B34 ICD10CM:B34.9 ICD9CM:060-066.99 ICD9CM:066.9 MESH:D001102 MESH:D014777 NCI:C3439 NCI:C34396 SNOMEDCT_US_2016_03_01:154319002 SNOMEDCT_US_2016_03_01:154345006 SNOMEDCT_US_2016_03_01:154372003 SNOMEDCT_US_2016_03_01:186619002 SNOMEDCT_US_2016_03_01:186754003 SNOMEDCT_US_2016_03_01:187471008 SNOMEDCT_US_2016_03_01:266116004 SNOMEDCT_US_2016_03_01:266188005 SNOMEDCT_US_2016_03_01:266194002 SNOMEDCT_US_2016_03_01:34014006 SNOMEDCT_US_2016_03_01:40610006 UMLS_CUI:C0003723 UMLS_CUI:C0042769 Viral Infection Viral disease virus infection disease_ontology DOID:934 viral infectious disease DOID:9341 ICD10CM:N36.1 ICD9CM:599.2 NCI:C39861 SNOMEDCT_US_2016_03_01:90531003 UMLS_CUI:C0152443 disease_ontology DOID:9341 urethral diverticulum DOID:9351 A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. ICD10CM:E08-E13 ICD10CM:E11 ICD9CM:250 MESH:D003920 NCI:C2985 SNOMEDCT_US_2016_03_01:154671004 SNOMEDCT_US_2016_03_01:191044006 SNOMEDCT_US_2016_03_01:267467004 SNOMEDCT_US_2016_03_01:73211009 UMLS_CUI:C0011849 disease_ontology DOID:9351 diabetes mellitus DOID:9352 A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly. EFO:0001360 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 SNOMEDCT_US_2016_03_01:154672006 SNOMEDCT_US_2016_03_01:190323008 SNOMEDCT_US_2016_03_01:190384004 SNOMEDCT_US_2016_03_01:267468009 SNOMEDCT_US_2016_03_01:44054006 UMLS_CUI:C0011860 NIDDM non-insulin-dependent diabetes mellitus type II diabetes mellitus disease_ontology DOID:9352 Xref MGI. OMIM mapping confirmed by DO. [SN]. type 2 diabetes mellitus DOID:936 DOID:8510 ICD10CM:G93.40 ICD10CM:G93.9 ICD9CM:348.3 ICD9CM:348.30 ICD9CM:348.9 MESH:D001927 NCI:C26920 NCI:C96413 SNOMEDCT_US_2016_03_01:155053002 SNOMEDCT_US_2016_03_01:193051008 SNOMEDCT_US_2016_03_01:193059005 SNOMEDCT_US_2016_03_01:76011009 SNOMEDCT_US_2016_03_01:81308009 UMLS_CUI:C0006111 UMLS_CUI:C0085584 encephalopathy disease_ontology DOID:936 brain disease DOID:9362 An asthma that is a life threatening condition with progressive respiratory failure, which does not respond to standard treatment. ICD9CM:493.91 MESH:D013224 NCI:C122577 SNOMEDCT_US_2016_03_01:155577001 SNOMEDCT_US_2016_03_01:195980003 SNOMEDCT_US_2016_03_01:266363006 SNOMEDCT_US_2016_03_01:36979006 SNOMEDCT_US_2016_03_01:57546000 SNOMEDCT_US_2016_03_01:708090002 UMLS_CUI:C0038218 Asthma with status asthmaticus Severe asthma attack disease_ontology DOID:9362 status asthmaticus DOID:9368 DOID:9367 ICD10CM:H16.2 ICD10CM:H16.20 ICD9CM:370.40 MESH:D007637 NCI:C34744 SNOMEDCT_US_2016_03_01:155154005 SNOMEDCT_US_2016_03_01:193757003 SNOMEDCT_US_2016_03_01:193780006 SNOMEDCT_US_2016_03_01:88151007 UMLS_CUI:C0022573 disease_ontology DOID:9368 keratoconjunctivitis DOID:9370 An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit. ICD10CM:H05.20 ICD9CM:376.30 MESH:D005094 NCI:C118763 NCI:C87114 SNOMEDCT_US_2016_03_01:155200004 SNOMEDCT_US_2016_03_01:18265008 SNOMEDCT_US_2016_03_01:267746003 UMLS_CUI:C0015300 proptosis disease_ontology DOID:9370 exophthalmos DOID:9406 A pituitary gland disease characterized by the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland. ICD10CM:E23.0 MESH:D007018 NCI:C62591 OMIM:221750 OMIM:262600 OMIM:262700 OMIM:613038 OMIM:613986 ORDO:95494 SNOMEDCT_US_2016_03_01:154703006 SNOMEDCT_US_2016_03_01:190469009 SNOMEDCT_US_2016_03_01:237681002 SNOMEDCT_US_2016_03_01:267482009 SNOMEDCT_US_2016_03_01:74728003 UMLS_CUI:C0020635 Pituitary insufficiency pituitary hormone deficiency disease_ontology Pituitary hypofunction DOID:9406 Xref MGI. hypopituitarism DOID:9408 ICD10CM:I21.3 ICD9CM:410 ICD9CM:410.9 ICD9CM:410.90 NCI:C35204 SNOMEDCT_US_2016_03_01:155304006 SNOMEDCT_US_2016_03_01:194796000 SNOMEDCT_US_2016_03_01:194811003 SNOMEDCT_US_2016_03_01:266288001 SNOMEDCT_US_2016_03_01:57054005 UMLS_CUI:C0155626 disease_ontology DOID:9408 acute myocardial infarction DOID:9409 ICD10CM:E23.2 ICD9CM:253.5 MESH:D003919 NCI:C43263 SNOMEDCT_US_2016_03_01:15771004 SNOMEDCT_US_2016_03_01:190484000 UMLS_CUI:C0011848 disease_ontology DOID:9409 diabetes insipidus DOID:9415 An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness. DOID:9416 DOID:9417 ICD10CM:J45 ICD9CM:493.0 SNOMEDCT_US_2016_03_01:155575009 SNOMEDCT_US_2016_03_01:16862005 SNOMEDCT_US_2016_03_01:195968006 SNOMEDCT_US_2016_03_01:195972005 SNOMEDCT_US_2016_03_01:233680000 SNOMEDCT_US_2016_03_01:266358007 SNOMEDCT_US_2016_03_01:266396008 SNOMEDCT_US_2016_03_01:389145006 SNOMEDCT_US_2016_03_01:389146007 UMLS_CUI:C0155877 extrinsic asthma with acute exacerbation extrinsic asthma with status asthmaticus disease_ontology atopic asthma DOID:9415 allergic asthma DOID:9432 ICD10CM:E74.8 ICD9CM:271.4 MESH:D006030 OMIM:233100 SNOMEDCT_US_2016_03_01:154737003 SNOMEDCT_US_2016_03_01:190759004 SNOMEDCT_US_2016_03_01:1913007 SNOMEDCT_US_2016_03_01:236367002 SNOMEDCT_US_2016_03_01:267430007 SNOMEDCT_US_2016_03_01:367418000 UMLS_CUI:C0017980 renal diabetes disease_ontology DOID:9432 OMIM mapping confirmed by DO. [SN]. renal glycosuria DOID:9446 A bile duct disease that is an inflammation of the bile duct. ICD10CM:K83.0 ICD9CM:576.1 MESH:D002761 NCI:C26718 SNOMEDCT_US_2016_03_01:155831003 SNOMEDCT_US_2016_03_01:197445007 SNOMEDCT_US_2016_03_01:82403002 UMLS_CUI:C0008311 disease_ontology DOID:9446 cholangitis DOID:9452 A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis. DOID:9451 ICD10CM:K70.0 ICD9CM:571.0 MESH:D005234 MESH:D005235 OMIM:228100 SNOMEDCT_US_2016_03_01:197321007 SNOMEDCT_US_2016_03_01:371330000 SNOMEDCT_US_2016_03_01:390002007 SNOMEDCT_US_2016_03_01:50325005 SNOMEDCT_US_2016_03_01:5360002 UMLS_CUI:C0015695 UMLS_CUI:C0015696 Fatty change of liver Steatosis of liver (disorder) alcoholic fatty liver hepatic lipidosis disease_ontology DOID:9452 PRISM. fatty liver disease DOID:9455 A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues. DOID:10583 ICD10CM:E75.6 ICD9CM:272.7 ICD9CM:272.8 MESH:D008064 SNOMEDCT_US_2016_03_01:10741005 SNOMEDCT_US_2016_03_01:11455007 SNOMEDCT_US_2016_03_01:154744007 SNOMEDCT_US_2016_03_01:190792005 SNOMEDCT_US_2016_03_01:190797004 SNOMEDCT_US_2016_03_01:190798009 SNOMEDCT_US_2016_03_01:190805007 SNOMEDCT_US_2016_03_01:267437005 SNOMEDCT_US_2016_03_01:267438000 UMLS_CUI:C0023794 UMLS_CUI:C0029591 Lipoid storage diseas Lipoidosis inborn lipid storage disorder lipoidosis disease_ontology DOID:9455 lipid storage disease DOID:9460 A uterine cancer that is located_in the uterine corpus. ICD10CM:C54 ICD10CM:C54.9 ICD9CM:182 NCI:C3556 SNOMEDCT_US_2016_03_01:154526001 SNOMEDCT_US_2016_03_01:188194001 SNOMEDCT_US_2016_03_01:188200009 SNOMEDCT_US_2016_03_01:269600001 SNOMEDCT_US_2016_03_01:363442002 SNOMEDCT_US_2016_03_01:371972005 SNOMEDCT_US_2016_03_01:93718007 UMLS_CUI:C0153574 corpus uteri cancer disease_ontology DOID:9460 uterine corpus cancer DOID:9467 ICD10CM:Q87.2 MESH:D009261 NCI:C75120 OMIM:161200 SNOMEDCT_US_2016_03_01:22199006 UMLS_CUI:C0027341 Fong disease Turner-Kiser syndrome hereditary onychoostedysplasia iliac horn syndrome nail patella syndrome disease_ontology DOID:9467 OMIM mapping confirmed by DO. [SN]. nail-patella syndrome DOID:9471 A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. DOID:9712 ICD10CM:G03 ICD10CM:G03.9 ICD9CM:322 ICD9CM:322.9 MESH:D008581 NCI:C26828 SNOMEDCT_US_2016_03_01:154983000 SNOMEDCT_US_2016_03_01:192678004 SNOMEDCT_US_2016_03_01:192681009 SNOMEDCT_US_2016_03_01:7180009 UMLS_CUI:C0025289 disease_ontology DOID:9471 meningitis DOID:9477 An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot. ICD10CM:I26 ICD10CM:I26.99 MESH:D011655 NCI:C50713 SNOMEDCT_US_2016_03_01:155326007 SNOMEDCT_US_2016_03_01:194882001 SNOMEDCT_US_2016_03_01:266292008 SNOMEDCT_US_2016_03_01:59282003 UMLS_CUI:C0034065 pulmonary artery embolism pulmonary embolus disease_ontology DOID:9477 PRISM. pulmonary embolism DOID:9478 An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth. ICD10CM:F53 MESH:D019052 NCI:C92852 SNOMEDCT_US_2016_03_01:147016002 SNOMEDCT_US_2016_03_01:154889000 SNOMEDCT_US_2016_03_01:191740008 SNOMEDCT_US_2016_03_01:192475007 SNOMEDCT_US_2016_03_01:268753005 SNOMEDCT_US_2016_03_01:58703003 UMLS_CUI:C0221074 Maternity blues postnatal depression disease_ontology DOID:9478 postpartum depression DOID:9500 ICD10CM:D72.9 ICD9CM:288 ICD9CM:288.9 MESH:D007960 SNOMEDCT_US_2016_03_01:154829002 SNOMEDCT_US_2016_03_01:191369001 SNOMEDCT_US_2016_03_01:54097007 UMLS_CUI:C0023510 disease_ontology DOID:9500 leukocyte disease DOID:9505 A substance abuse that involves the recurring use of cannabis despite negative consequences. DOID:2525 ICD10CM:F12 ICD10CM:F12.1 ICD9CM:305.2 MESH:D002189 SNOMEDCT_US_2016_03_01:268769003 SNOMEDCT_US_2016_03_01:37344009 UMLS_CUI:C0006868 UMLS_CUI:C0024809 marijuana abuse disease_ontology DOID:9505 cannabis abuse DOID:9521 ICD10CM:E34.3 MESH:D046150 OMIM:262500 SNOMEDCT_US_2016_03_01:38196001 UMLS_CUI:C0271568 Laron-type isolated somatotropin defect (disorder) disease_ontology DOID:9521 OMIM mapping confirmed by DO. [SN]. Laron syndrome DOID:9538 A myeloid neoplasm that is located_in the plasma cells in bone marrow. EFO:0001378 ICD10CM:C90.0 ICD10CM:C90.00 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 SNOMEDCT_US_2016_03_01:109989006 SNOMEDCT_US_2016_03_01:154585004 SNOMEDCT_US_2016_03_01:55921005 SNOMEDCT_US_2016_03_01:94705007 UMLS_CUI:C0026764 plasma cell myeloma disease_ontology DOID:9538 OMIM mapping confirmed by DO. [SN]. multiple myeloma DOID:9553 An endocrine system disease that is located_in the adrenal gland. ICD10CM:E27.9 ICD9CM:255 ICD9CM:255.9 MESH:D000307 NCI:C26690 SNOMEDCT_US_2016_03_01:154704000 SNOMEDCT_US_2016_03_01:190532009 SNOMEDCT_US_2016_03_01:30171000 UMLS_CUI:C0001621 disease_ontology DOID:9553 adrenal gland disease DOID:9562 A ciliopathy that is characterized by impaired function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube. DOID:2925 MESH:D002925 NCI:C84638 OMIM:PS244400 SNOMEDCT_US_2016_03_01:86204009 SNOMEDCT_US_2016_03_01:9057007 UMLS_CUI:C0008780 ciliary motility disorder immotile ciliary syndrome disease_ontology DOID:9562 Xref MGI. OMIM mapping confirmed by DO. [SN]. primary ciliary dyskinesia DOID:9563 A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances. DOID:11046 DOID:11047 DOID:9571 ICD10CM:J47 ICD10CM:J47.9 ICD9CM:494 MESH:D001987 NCI:C84475 OMIM:211400 OMIM:613021 OMIM:613071 ORDO:60033 SNOMEDCT_US_2016_03_01:12295008 SNOMEDCT_US_2016_03_01:155580000 SNOMEDCT_US_2016_03_01:195986009 UMLS_CUI:C0006267 Polynesian bronchiectasis disease_ontology DOID:9563 Xref MGI. OMIM mapping confirmed by DO. [SN]. bronchiectasis DOID:9574 DOID:14713 ICD10CM:Q30.0 ICD9CM:748.0 MESH:C562435 MESH:D002754 OMIM:608911 SNOMEDCT_US_2016_03_01:14988006 SNOMEDCT_US_2016_03_01:156934002 SNOMEDCT_US_2016_03_01:204508009 SNOMEDCT_US_2016_03_01:204509001 SNOMEDCT_US_2016_03_01:204514002 SNOMEDCT_US_2016_03_01:53458004 UMLS_CUI:C0008297 UMLS_CUI:C0220723 Atresia of nares Imperforate nares posterior choanal atresia disease_ontology DOID:9574 OMIM mapping confirmed by DO. [SN]. choanal atresia DOID:9577 A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates. ICD10CM:P37.5 ICD9CM:771.7 NCI:C116810 SNOMEDCT_US_2016_03_01:157121009 SNOMEDCT_US_2016_03_01:206362009 SNOMEDCT_US_2016_03_01:3973009 SNOMEDCT_US_2016_03_01:414821002 UMLS_CUI:C0276682 Neonatal Candida infection Neonatal candida infection Neonatal monilia infection (disorder) neonatal moniliasis disease_ontology DOID:9577 neonatal candidiasis DOID:9588 A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms. DOID:2160 MESH:D004660 NCI:C26760 SNOMEDCT_US_2016_03_01:192736002 SNOMEDCT_US_2016_03_01:267578009 SNOMEDCT_US_2016_03_01:267682000 SNOMEDCT_US_2016_03_01:45170000 UMLS_CUI:C0014038 disease_ontology DOID:9588 encephalitis DOID:9589 ICD10CM:N21.1 ICD9CM:594.2 NCI:C26995 SNOMEDCT_US_2016_03_01:155880008 SNOMEDCT_US_2016_03_01:20342001 UMLS_CUI:C0162301 urethral Stone disease_ontology DOID:9589 urethral calculus DOID:9590 A urinary system disease that is located_in the lower urinary tract and is characterized by the formation of a stone. ICD10CM:N21 ICD10CM:N21.9 ICD9CM:594 ICD9CM:594.9 SNOMEDCT_US_2016_03_01:155878002 SNOMEDCT_US_2016_03_01:155881007 SNOMEDCT_US_2016_03_01:197828005 SNOMEDCT_US_2016_03_01:197832004 SNOMEDCT_US_2016_03_01:79509009 UMLS_CUI:C0156264 disease_ontology DOID:9590 lower urinary tract calculus DOID:9597 MESH:D007725 NCI:C3153 SNOMEDCT_US_2016_03_01:359987004 SNOMEDCT_US_2016_03_01:4305004 SNOMEDCT_US_2016_03_01:94455000 UMLS_CUI:C0022790 Krukenberg neoplasm disease_ontology Krukenberg tumor DOID:9597 Krukenberg carcinoma DOID:9598 ICD10CM:M72.9 ICD9CM:729.4 MESH:D005208 NCI:C50559 SNOMEDCT_US_2016_03_01:203123000 SNOMEDCT_US_2016_03_01:36948007 UMLS_CUI:C0015645 disease_ontology DOID:9598 fasciitis DOID:96 A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness. ICD10CM:A05.0 ICD9CM:005.0 MESH:D013202 NCI:C35037 SNOMEDCT_US_2016_03_01:84622004 UMLS_CUI:C0038159 Staphylococcal food poisoning Staphylococcal toxaemia due to food staphyloenterotoxicosis disease_ontology DOID:96 staphyloenterotoxemia DOID:9602 ICD10CM:M72.6 ICD9CM:728.86 MESH:D019115 NCI:C84916 SNOMEDCT_US_2016_03_01:186428007 SNOMEDCT_US_2016_03_01:52486002 UMLS_CUI:C0238124 disease_ontology DOID:9602 necrotizing fasciitis DOID:962 MESH:D009455 NCI:C3272 SNOMEDCT_US_2016_03_01:115242003 SNOMEDCT_US_2016_03_01:134214003 SNOMEDCT_US_2016_03_01:189947001 SNOMEDCT_US_2016_03_01:404029005 SNOMEDCT_US_2016_03_01:89084002 UMLS_CUI:C0027830 disease_ontology DOID:962 neurofibroma DOID:9620 A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter. ICD10CM:N13.7 ICD10CM:N13.70 ICD9CM:593.7 MESH:D014718 NCI:C84467 OMIM:193000 OMIM:314550 OMIM:610878 OMIM:613674 OMIM:614317 OMIM:614318 OMIM:614319 OMIM:614674 OMIM:615390 OMIM:615963 ORDO:289365 SNOMEDCT_US_2016_03_01:155875004 SNOMEDCT_US_2016_03_01:197811007 SNOMEDCT_US_2016_03_01:251994004 SNOMEDCT_US_2016_03_01:26836002 UMLS_CUI:C0042580 vesico-ureteral reflux disease_ontology DOID:9620 Xref MGI. OMIM mapping confirmed by DO. [LS]. vesicoureteral reflux DOID:9622 ICD10CM:N28.81 ICD9CM:593.1 NCI:C122991 SNOMEDCT_US_2016_03_01:197800004 SNOMEDCT_US_2016_03_01:88531004 UMLS_CUI:C0156259 disease_ontology DOID:9622 kidney hypertrophy DOID:963 A hereditary ataxia characterized by sporadic bouts of ataxia with or without continuous muscle movement. MESH:C580065 ORDO:211062 SNOMEDCT_US_2016_03_01:421455009 UMLS_CUI:C1720189 Isaacs syndrome disease_ontology DOID:963 Xref MGI. OMIM mapping confirmed by DO. [SN]. Updated outdated UMLS CUI. episodic ataxia DOID:9637 ICD10CM:K12.1 MESH:D013280 NCI:C26887 SNOMEDCT_US_2016_03_01:155660009 SNOMEDCT_US_2016_03_01:196527002 SNOMEDCT_US_2016_03_01:61170000 SNOMEDCT_US_2016_03_01:95361005 UMLS_CUI:C0038362 disease_ontology DOID:9637 stomatitis DOID:9649 A pathologic nystagmus, present at birth, characterized by involuntary, rhythmic eye movements; oscillations are usually horizontal in direction. ICD10CM:H55.01 ICD9CM:379.51 MESH:D020417 OMIM:164100 OMIM:193003 OMIM:300589 OMIM:300814 OMIM:608345 OMIM:614826 ORDO:651 SNOMEDCT_US_2016_03_01:155205009 SNOMEDCT_US_2016_03_01:194173005 SNOMEDCT_US_2016_03_01:267750005 SNOMEDCT_US_2016_03_01:64635004 UMLS_CUI:C0700501 disease_ontology DOID:9649 Xref MGI. congenital nystagmus DOID:9650 ICD10CM:H55.0 ICD10CM:H55.00 ICD9CM:379.50 MESH:D009759 NCI:C3282 SNOMEDCT_US_2016_03_01:155205009 SNOMEDCT_US_2016_03_01:194171007 SNOMEDCT_US_2016_03_01:194172000 SNOMEDCT_US_2016_03_01:267750005 SNOMEDCT_US_2016_03_01:563001 UMLS_CUI:C0028738 disease_ontology DOID:9650 pathologic nystagmus DOID:9663 A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers. ICD9CM:528.2 MESH:D013281 NCI:C62546 SNOMEDCT_US_2016_03_01:110426005 SNOMEDCT_US_2016_03_01:155661008 SNOMEDCT_US_2016_03_01:196529004 SNOMEDCT_US_2016_03_01:196534000 SNOMEDCT_US_2016_03_01:196536003 SNOMEDCT_US_2016_03_01:303117009 SNOMEDCT_US_2016_03_01:321258009 SNOMEDCT_US_2016_03_01:322224003 SNOMEDCT_US_2016_03_01:367526005 SNOMEDCT_US_2016_03_01:398870000 SNOMEDCT_US_2016_03_01:426965005 SNOMEDCT_US_2016_03_01:427617000 SNOMEDCT_US_2016_03_01:83312008 UMLS_CUI:C0038363 Aphtha (morphologic abnormality) Aphthous ulceration (disorder) Canker sore Oral aphthae oral ulcer disease_ontology Oral aphthous ulcer DOID:9663 aphthous stomatitis DOID:9669 ICD10CM:H25 ICD9CM:366.1 ICD9CM:366.10 NCI:C35012 SNOMEDCT_US_2016_03_01:155127007 SNOMEDCT_US_2016_03_01:193582000 SNOMEDCT_US_2016_03_01:193583005 SNOMEDCT_US_2016_03_01:193594009 SNOMEDCT_US_2016_03_01:39450006 UMLS_CUI:C0036646 disease_ontology DOID:9669 senile cataract DOID:9682 A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood. DOID:9683 DOID:9684 ICD10CM:A95 ICD10CM:A95.9 ICD9CM:060 ICD9CM:060.9 MESH:D015004 NCI:C35547 SNOMEDCT_US_2016_03_01:154345006 SNOMEDCT_US_2016_03_01:16541001 SNOMEDCT_US_2016_03_01:186587002 SNOMEDCT_US_2016_03_01:187411002 SNOMEDCT_US_2016_03_01:266194002 UMLS_CUI:C0043395 Sylvatic yellow fever Yellow fever, sylvan jungle yellow fever urban yellow fever disease_ontology DOID:9682 yellow fever DOID:970 MESH:D013717 SNOMEDCT_US_2016_03_01:156666009 SNOMEDCT_US_2016_03_01:240035004 SNOMEDCT_US_2016_03_01:268092005 SNOMEDCT_US_2016_03_01:67801009 UMLS_CUI:C0039520 Inflammation of tendon sheath disease_ontology DOID:970 tenosynovitis DOID:971 ICD10CM:M77.9 MESH:D052256 NCI:C97141 SNOMEDCT_US_2016_03_01:156665008 SNOMEDCT_US_2016_03_01:202893001 SNOMEDCT_US_2016_03_01:267996008 SNOMEDCT_US_2016_03_01:268091003 SNOMEDCT_US_2016_03_01:312785002 SNOMEDCT_US_2016_03_01:34840004 UMLS_CUI:C0039503 disease_ontology DOID:971 tendinitis DOID:9719 MESH:D018630 SNOMEDCT_US_2016_03_01:193364004 SNOMEDCT_US_2016_03_01:232016005 UMLS_CUI:C0242852 Retinitis proliferans disease_ontology DOID:9719 proliferative vitreoretinopathy DOID:9720 An eye and adnexa disease that is located in the vitreous of the eye. ICD10CM:H43.3 ICD10CM:H43.39 ICD9CM:379.24 SNOMEDCT_US_2016_03_01:194154006 SNOMEDCT_US_2016_03_01:194636006 UMLS_CUI:C0029872 disease_ontology DOID:9720 vitreous disease DOID:9726 ICD10CM:H43.81 MESH:D020255 NCI:C50807 SNOMEDCT_US_2016_03_01:155202007 SNOMEDCT_US_2016_03_01:267747007 SNOMEDCT_US_2016_03_01:393583008 SNOMEDCT_US_2016_03_01:53772007 UMLS_CUI:C0042907 disease_ontology DOID:9726 vitreous detachment DOID:974 A respiratory system disease which involves the upper respiratory tract. ICD9CM:478.1 ICD9CM:478.19 SNOMEDCT_US_2016_03_01:195823002 SNOMEDCT_US_2016_03_01:266346007 UMLS_CUI:C0029581 disease_ontology DOID:974 upper respiratory tract disease DOID:9741 ICD10CM:K83.9 ICD9CM:576.9 MESH:D001660 SNOMEDCT_US_2016_03_01:105997008 SNOMEDCT_US_2016_03_01:155830002 SNOMEDCT_US_2016_03_01:155832005 SNOMEDCT_US_2016_03_01:266544009 SNOMEDCT_US_2016_03_01:266545005 SNOMEDCT_US_2016_03_01:5235004 UMLS_CUI:C0005424 disease_ontology DOID:9741 biliary tract disease DOID:9742 ICD10CM:I86.2 ICD9CM:456.5 SNOMEDCT_US_2016_03_01:17406005 SNOMEDCT_US_2016_03_01:195481006 SNOMEDCT_US_2016_03_01:266271008 UMLS_CUI:C0155795 disease_ontology DOID:9742 pelvic varices DOID:9743 ICD9CM:250.6 MESH:D003929 NCI:C26748 SNOMEDCT_US_2016_03_01:154683002 SNOMEDCT_US_2016_03_01:190349003 SNOMEDCT_US_2016_03_01:190353001 SNOMEDCT_US_2016_03_01:193182005 SNOMEDCT_US_2016_03_01:230572002 SNOMEDCT_US_2016_03_01:267472008 SNOMEDCT_US_2016_03_01:866003 UMLS_CUI:C0011882 disease_ontology DOID:9743 diabetic neuropathy DOID:9744 A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas. EFO:0001359 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 OMIM:300136 SNOMEDCT_US_2016_03_01:154673001 SNOMEDCT_US_2016_03_01:190322003 SNOMEDCT_US_2016_03_01:190362004 SNOMEDCT_US_2016_03_01:267469001 SNOMEDCT_US_2016_03_01:46635009 UMLS_CUI:C0011854 IDDM insulin-dependent diabetes mellitus type I diabetes mellitus disease_ontology DOID:9744 Xref MGI. OMIM mapping confirmed by DO. [SN]. type 1 diabetes mellitus DOID:9746 A pelvic varix disease characterized by swollen, inflamed veins around the anus or lower rectum. ICD10CM:K64 ICD9CM:455 MESH:D006484 NCI:C26792 SNOMEDCT_US_2016_03_01:155469003 SNOMEDCT_US_2016_03_01:155477004 SNOMEDCT_US_2016_03_01:195472000 SNOMEDCT_US_2016_03_01:70153002 UMLS_CUI:C0019112 hemorrhoidal disease disease_ontology DOID:9746 hemorrhoid DOID:9778 A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause. ICD10CM:K58 ICD10CM:K58.9 ICD9CM:564.1 KEGG:05321 MESH:D043183 NCI:C82343 SNOMEDCT_US_2016_03_01:10743008 SNOMEDCT_US_2016_03_01:155783000 SNOMEDCT_US_2016_03_01:192434000 SNOMEDCT_US_2016_03_01:197124009 SNOMEDCT_US_2016_03_01:266525002 UMLS_CUI:C0022104 IBD Irritable colon disease_ontology Psychogenic IBS DOID:9778 irritable bowel syndrome DOID:9779 ICD10CM:K59.9 ICD9CM:564.9 SNOMEDCT_US_2016_03_01:81120009 UMLS_CUI:C0016807 disease_ontology DOID:9779 bowel dysfunction DOID:9784 A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi . Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur. ICD10CM:B75 ICD9CM:124 MESH:D014235 NCI:C85199 SNOMEDCT_US_2016_03_01:154415009 SNOMEDCT_US_2016_03_01:266222003 SNOMEDCT_US_2016_03_01:709018004 SNOMEDCT_US_2016_03_01:88264003 UMLS_CUI:C0040896 Trichinella spiralis infection disease_ontology DOID:9784 trichinosis DOID:9794 ICD10CM:H31.2 ICD10CM:H31.20 ICD9CM:363.5 ICD9CM:363.50 SNOMEDCT_US_2016_03_01:193465004 SNOMEDCT_US_2016_03_01:193473008 SNOMEDCT_US_2016_03_01:74469006 UMLS_CUI:C0154893 disease_ontology DOID:9794 hereditary choroidal atrophy DOID:9799 ICD10CM:H44.30 ICD10CM:H44.5 ICD9CM:360.2 ICD9CM:360.20 ICD9CM:360.4 ICD9CM:360.40 SNOMEDCT_US_2016_03_01:193275003 SNOMEDCT_US_2016_03_01:193279009 SNOMEDCT_US_2016_03_01:193285002 SNOMEDCT_US_2016_03_01:193292007 SNOMEDCT_US_2016_03_01:62585004 UMLS_CUI:C0154777 disease_ontology DOID:9799 eye degenerative disease DOID:980 ICD10CM:H31.1 ICD10CM:H31.10 ICD9CM:363.4 ICD9CM:363.40 MESH:C535358 OMIM:215500 SNOMEDCT_US_2016_03_01:193461008 SNOMEDCT_US_2016_03_01:193464000 SNOMEDCT_US_2016_03_01:247199007 SNOMEDCT_US_2016_03_01:267617003 SNOMEDCT_US_2016_03_01:406446000 SNOMEDCT_US_2016_03_01:47638000 UMLS_CUI:C0344297 Choroidal degenerations disease_ontology DOID:980 OMIM mapping confirmed by DO. [SN]. choroidal sclerosis DOID:9822 ICD9CM:363.53 OMIM:613105 SNOMEDCT_US_2016_03_01:193468002 SNOMEDCT_US_2016_03_01:80526002 UMLS_CUI:C0339427 Choroidal dystrophy, central areolar disease_ontology DOID:9822 OMIM mapping confirmed by DO. [SN]. partial central choroid dystrophy DOID:9828 A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment. DOID:6679 ICD10CM:P96.1 ICD9CM:779.5 MESH:D009357 NCI:C35808 NCI:C87101 SNOMEDCT_US_2016_03_01:414819007 SNOMEDCT_US_2016_03_01:61628006 UMLS_CUI:C0027609 UMLS_CUI:C1332133 Drug withdrawal syndrome in newborn disease_ontology DOID:9828 neonatal abstinence syndrome DOID:9834 ICD10CM:H52.0 ICD9CM:367.0 MESH:D006956 SNOMEDCT_US_2016_03_01:155132008 SNOMEDCT_US_2016_03_01:38101003 UMLS_CUI:C0020490 Far-sightedness hypermetropia disease_ontology DOID:9834 hyperopia DOID:9835 EFO:0003908 ICD10CM:H52.7 MESH:D012030 NCI:C87145 SNOMEDCT_US_2016_03_01:21324001 SNOMEDCT_US_2016_03_01:267723000 SNOMEDCT_US_2016_03_01:314027003 SNOMEDCT_US_2016_03_01:39021009 UMLS_CUI:C0034951 disease_ontology DOID:9835 refractive error DOID:9840 Esotropia is a strabismus in which the eye turns inward toward the nose. ICD10CM:H50.0 ICD10CM:H50.00 ICD9CM:378.0 ICD9CM:378.00 MESH:D004948 NCI:C34596 SNOMEDCT_US_2016_03_01:155193001 SNOMEDCT_US_2016_03_01:16596007 SNOMEDCT_US_2016_03_01:194074002 SNOMEDCT_US_2016_03_01:194085000 UMLS_CUI:C0014877 Convergence in manifest squint Internal Strabismus crossed eyes disease_ontology DOID:9840 esotropia DOID:9847 ICD10CM:H81.3 ICD10CM:H81.39 ICD10CM:H81.399 ICD9CM:386.1 ICD9CM:386.19 SNOMEDCT_US_2016_03_01:194353007 SNOMEDCT_US_2016_03_01:194359006 SNOMEDCT_US_2016_03_01:194692006 UMLS_CUI:C0029706 disease_ontology DOID:9847 peripheral vertigo DOID:9848 ICD10CM:H81.0 MESH:D018159 SNOMEDCT_US_2016_03_01:194346003 SNOMEDCT_US_2016_03_01:27621000119100 SNOMEDCT_US_2016_03_01:70831000119103 SNOMEDCT_US_2016_03_01:9794007 UMLS_CUI:C0206586 labyrinthine hydrops disease_ontology DOID:9848 endolymphatic hydrops DOID:9849 A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss. ICD10CM:H81.0 ICD10CM:H81.09 ICD9CM:386.0 ICD9CM:386.00 MESH:D008575 OMIM:156000 SNOMEDCT_US_2016_03_01:13445001 SNOMEDCT_US_2016_03_01:155235002 SNOMEDCT_US_2016_03_01:194346003 SNOMEDCT_US_2016_03_01:194347007 SNOMEDCT_US_2016_03_01:194352002 UMLS_CUI:C0025281 Meniere disease Mnire's vertigo Otogenic vertigo disease_ontology DOID:9849 OMIM mapping confirmed by DO. [SN]. Meniere's disease DOID:9854 ICD10CM:G24.4 ICD9CM:333.82 MESH:D009069 SNOMEDCT_US_2016_03_01:155007009 SNOMEDCT_US_2016_03_01:192861006 SNOMEDCT_US_2016_03_01:267689009 SNOMEDCT_US_2016_03_01:49386006 UMLS_CUI:C0152115 Oro-facial dyskinesia disease_ontology DOID:9854 lingual-facial-buccal dyskinesia DOID:986 A hypersensitivity reaction type II disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots. EFO:0004192 ICD10CM:L63 ICD10CM:L63.9 ICD9CM:704.01 MESH:D000506 OMIM:104000 OMIM:610753 SNOMEDCT_US_2016_03_01:201131001 SNOMEDCT_US_2016_03_01:238727007 SNOMEDCT_US_2016_03_01:68225006 UMLS_CUI:C0002171 Circumscribed alopecia disease_ontology DOID:986 alopecia areata DOID:987 A hypotrichosis that is characterized by a loss of hair from the head or body. ICD10CM:L65.9 ICD9CM:704.0 ICD9CM:704.00 MESH:D000505 NCI:C50575 OMIM:109200 OMIM:300042 SNOMEDCT_US_2016_03_01:156408004 SNOMEDCT_US_2016_03_01:201129005 SNOMEDCT_US_2016_03_01:201130000 SNOMEDCT_US_2016_03_01:201157003 SNOMEDCT_US_2016_03_01:267810004 SNOMEDCT_US_2016_03_01:270504008 SNOMEDCT_US_2016_03_01:278040002 SNOMEDCT_US_2016_03_01:56317004 UMLS_CUI:C0002170 disease_ontology DOID:987 alopecia DOID:9870 A carbohydrate metabolic disorder that involves a defect in galactose metabolism resulting in toxic levels of galactose 1-phosphate in various tissues. ICD10CM:E74.21 ICD9CM:271.1 MESH:D005693 NCI:C84723 OMIM:230350 OMIM:230400 SNOMEDCT_US_2016_03_01:154738008 SNOMEDCT_US_2016_03_01:190745006 SNOMEDCT_US_2016_03_01:190747003 SNOMEDCT_US_2016_03_01:190749000 SNOMEDCT_US_2016_03_01:267498002 SNOMEDCT_US_2016_03_01:38177000 UMLS_CUI:C0016952 Galactosaemia Galactose intolerance disease_ontology DOID:9870 OMIM mapping by NeuroDevNet. [LS]. galactosemia DOID:9884 A myopathy is characterized by progressive skeletal muscle weakness degeneration. ICD10CM:G71.0 ICD9CM:359.1 MESH:D009136 NCI:C84910 OMIM:158800 OMIM:159050 OMIM:309930 OMIM:309950 OMIM:310000 OMIM:310095 OMIM:600416 SNOMEDCT_US_2016_03_01:155095006 SNOMEDCT_US_2016_03_01:193225000 SNOMEDCT_US_2016_03_01:193236007 SNOMEDCT_US_2016_03_01:193257004 SNOMEDCT_US_2016_03_01:267712004 SNOMEDCT_US_2016_03_01:44292004 SNOMEDCT_US_2016_03_01:73297009 UMLS_CUI:C0026850 disease_ontology DOID:9884 muscular dystrophy DOID:9892 ICD10CM:I77.4 ICD9CM:447.4 SNOMEDCT_US_2016_03_01:9250002 UMLS_CUI:C0152098 Celiac artery compression syndrome Harjola-Marable syndrome Marable's syndrome disease_ontology DOID:9892 median arcuate ligament syndrome DOID:9923 A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired. ICD10CM:F82 ICD9CM:315.4 MESH:D019957 NCI:C92561 SNOMEDCT_US_2016_03_01:192578006 SNOMEDCT_US_2016_03_01:27544004 UMLS_CUI:C0011757 disease_ontology DOID:9923 developmental coordination disorder DOID:9931 An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland. DOID:12613 MESH:D014884 NCI:C85225 SNOMEDCT_US_2016_03_01:154709005 SNOMEDCT_US_2016_03_01:267484005 UMLS_CUI:C0043068 Meningococcal hemorrhagic adrenalitis WFS disease_ontology DOID:9931 Waterhouse-Friderichsen syndrome DOID:9942 NCI:C35346 SNOMEDCT_US_2016_03_01:76616003 UMLS_CUI:C0272394 disease_ontology DOID:9942 lymph node disease DOID:9946 ICD9CM:365.3 SNOMEDCT_US_2016_03_01:1654001 SNOMEDCT_US_2016_03_01:193550003 UMLS_CUI:C0339578 Corticosteroid-induced glaucoma disease_ontology DOID:9946 steroid-induced glaucoma DOID:9952 A lymphoblastic leukemia that is characterized by over production of lymphoblasts. EFO:0000220 ICD10CM:C91.0 ICD10CM:C91.00 ICD9CM:204.0 NCI:C3167 OMIM:247640 OMIM:613065 OMIM:613067 OMIM:615545 ORDO:513 SNOMEDCT_US_2016_03_01:128822004 SNOMEDCT_US_2016_03_01:154588002 SNOMEDCT_US_2016_03_01:190034000 SNOMEDCT_US_2016_03_01:90151006 SNOMEDCT_US_2016_03_01:91857003 UMLS_CUI:C0023449 acute lymphoblastic leukemia disease_ontology DOID:9952 Xref MGI. acute lymphocytic leukemia DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C3283 OMIM:601665 SNOMEDCT_US_2016_03_01:154776002 SNOMEDCT_US_2016_03_01:190963004 SNOMEDCT_US_2016_03_01:414915002 SNOMEDCT_US_2016_03_01:414916001 SNOMEDCT_US_2016_03_01:5476005 UMLS_CUI:C0028754 disease_ontology DOID:9970 OMIM mapping confirmed by DO. [SN]. obesity DOID:9971 ICD10CM:E67.3 ICD9CM:278.4 SNOMEDCT_US_2016_03_01:190969000 SNOMEDCT_US_2016_03_01:27712000 UMLS_CUI:C1442839 disease_ontology DOID:9971 hypervitaminosis D DOID:9973 A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance. NCI:C35458 SNOMEDCT_US_2016_03_01:103326000 SNOMEDCT_US_2016_03_01:255338002 UMLS_CUI:C0439857 disease_ontology DOID:9973 substance dependence DOID:9974 A substance dependence that involves the continued use of drugs despite problems related to use of the substance. ICD9CM:304.6 ICD9CM:304.60 SNOMEDCT_US_2016_03_01:191859004 SNOMEDCT_US_2016_03_01:191860009 SNOMEDCT_US_2016_03_01:191864000 SNOMEDCT_US_2016_03_01:268644006 UMLS_CUI:C0029792 disease_ontology DOID:9974 drug dependence DOID:9975 A drug dependence that is a psychological dependency on the regular use of cocaine. ICD10CM:F14.2 ICD9CM:304.2 ICD9CM:304.20 MESH:D019970 NCI:C34492 SNOMEDCT_US_2016_03_01:191829009 SNOMEDCT_US_2016_03_01:191830004 SNOMEDCT_US_2016_03_01:191834008 SNOMEDCT_US_2016_03_01:192254002 SNOMEDCT_US_2016_03_01:286934009 SNOMEDCT_US_2016_03_01:31956009 UMLS_CUI:C0600427 disease_ontology DOID:9975 cocaine dependence DOID:9976 An opiate dependence that involves the continued use of heroin despite problems related to use of the substance. MESH:D006556 NCI:C34694 SNOMEDCT_US_2016_03_01:191817000 SNOMEDCT_US_2016_03_01:192220003 SNOMEDCT_US_2016_03_01:231477003 UMLS_CUI:C0019337 disease_ontology DOID:9976 heroin dependence DOID:9977 A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance. ICD10CM:F16.2 ICD9CM:304.5 ICD9CM:304.50 NCI:C34657 SNOMEDCT_US_2016_03_01:191847003 SNOMEDCT_US_2016_03_01:191848008 SNOMEDCT_US_2016_03_01:191852008 SNOMEDCT_US_2016_03_01:268643000 SNOMEDCT_US_2016_03_01:38247002 UMLS_CUI:C0018528 disease_ontology DOID:9977 hallucinogen dependence DOID:998 ICD9CM:710.5 MESH:D016603 SNOMEDCT_US_2016_03_01:95416007 UMLS_CUI:C0085179 Eosinophilia myalgia syndrome disease_ontology DOID:998 eosinophilia-myalgia syndrome DOID:9986 MESH:C537131 NCI:C6244 SNOMEDCT_US_2016_03_01:13048006 UMLS_CUI:C0271333 Lymphoma of the orbit disease_ontology DOID:9986 orbit lymphoma DOID:9988 A tertiary syphilis that results_in infection located_in brain or located_in spinal cord. ICD10CM:A52.3 ICD9CM:094 ICD9CM:094.9 MESH:D009494 NCI:C84935 SNOMEDCT_US_2016_03_01:154384001 SNOMEDCT_US_2016_03_01:186884004 SNOMEDCT_US_2016_03_01:186895005 SNOMEDCT_US_2016_03_01:187356008 SNOMEDCT_US_2016_03_01:26039008 SNOMEDCT_US_2016_03_01:266210001 UMLS_CUI:C0027927 late neurosyphilis disease_ontology DOID:9988 tertiary neurosyphilis DOID:999 ICD10CM:D72.1 ICD9CM:288.3 MESH:D004802 MESH:D017681 SNOMEDCT_US_2016_03_01:165524009 SNOMEDCT_US_2016_03_01:191363000 SNOMEDCT_US_2016_03_01:27955006 SNOMEDCT_US_2016_03_01:418928000 UMLS_CUI:C0014457 Eosinophilic leukocytosis eosinophilia disease_ontology DOID:999 hypereosinophilic syndrome DOID:9993 ICD10CM:E16.2 ICD9CM:251.2 MESH:D007003 NCI:C3126 SNOMEDCT_US_2016_03_01:154691006 SNOMEDCT_US_2016_03_01:154693009 SNOMEDCT_US_2016_03_01:190433001 SNOMEDCT_US_2016_03_01:190436009 SNOMEDCT_US_2016_03_01:237630007 SNOMEDCT_US_2016_03_01:271327008 SNOMEDCT_US_2016_03_01:302866003 SNOMEDCT_US_2016_03_01:66694000 UMLS_CUI:C0020615 Hypoglycaemia disease_ontology DOID:9993 hypoglycemia PR:000000001 An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA. protein PR:000000001 Proteins descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB]. protein PR:000000001 Lower, narrow portion of the uterus where it joins with the top end of the vagina. The narrow caudal end of the uterus that opens into the vagina. [TFD][VHOG] The evolution of mammals is associated with radical changes in their reproductive biology, particularly the structure and function of the female reproductive organs. These changes include the evolution of the uterus, cervix, vagina, placenta and specialized cell types associated with each of those structures.[well established][VHOG] cervical cervix BTO:0001421 BTO:0002249 CALOHA:TS-0134 EFO:0000979 EMAPA:29927 EV:0100114 FMA:17740 GAID:376 MA:0000392 MAT:0000292 MESH:A05.360.319.679.256 OpenCyc:Mx4rvVipEJwpEbGdrcN5Y29ycA UMLS:C0007874 VHOG:0001359 galen:CervixUteri ncithesaurus:Cervix canalis cervicis uteri caudal segment of uterus cervical canal of uterus cervix uteri neck of uterus uterine cervix uberon cervical canal cervix of uterus UBERON:0000002 uterine cervix UBERON:0000002 Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs. In humans, organ with organ cavity which connects the renal sinus to the urinary bladder. Examples: the right and the left ureters. Anatomical structure consisting of long narrow duct which carries urine from the kidney to the urinary bladder.[AAO] The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG] ureteral ureteric AAO:0010254 BTO:0001409 CALOHA:TS-1084 EFO:0000930 EHDAA2:0002139 EHDAA:9341 EMAPA:17950 EV:0100097 FMA:9704 GAID:438 MA:0000378 MAT:0000120 MESH:A05.810.776 MIAA:0000120 OpenCyc:Mx4rvhmm6JwpEbGdrcN5Y29ycA UMLS:C0041951 VHOG:0000605 XAO:0000144 galen:Ureter ncithesaurus:Ureter uberon metanephric duct UBERON:0000056 ureter UBERON:0000056 Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. Portion of the alimentary canal bounded anteriorly by the pyloric sphincter and posteriorly by the cloacal sphincter.[AAO] The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] intestinal AAO:0000246 ANISEED:1235303 BSA:0000093 BTO:0000648 CALOHA:TS-0490 EFO:0000834 EMAPA:32874 EV:0100071 FMA:7199 GAID:295 MA:0000328 MA:0001524 MESH:A03.492.411 MIAA:0000043 TAO:0001338 UMLS:C0021853 VHOG:0000056 WBbt:0005772 XAO:0000129 ZFA:0001338 galen:Intestine ncithesaurus:Intestine bowel uberon UBERON:0000160 Editor notes: This class is probably too inclusive. Taxon notes: [in zebrafish] No stomach, small intestine, or large intestine can be distinguished. However, differences can be found in the morphology of the mucosa columnar epithelial cells and the number of goblet cells, suggesting functional differentiation. The intestine has numerous folds that become progressively shorter in a rostral-to-caudal direction. Proportionally, these folds are significantly larger than the finger-like intestinal villi of mammals and other amniotes (Wallace et al. 2005). Columnar-shaped absorptive enterocytes are the most numerous in the zebrafish intestinal epithelium. Goblet cells are the second most populous epithelial cell type. intestine UBERON:0000160 The breast is the upper ventral region of an animal's torso, particularly that of mammals, including human beings. The breasts of a female primate’s body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's. [WP,unvetted]. BTO:0000149 CALOHA:TS-2083 EV:0100124 FMA:9601 GAID:33 MESH:A01.236 OpenCyc:Mx4rvVjV7ZwpEbGdrcN5Y29ycA UMLS:C0006141 galen:Breast ncithesaurus:Breast mammary part of chest mammary region uberon mamma UBERON:0000310 breast UBERON:0000310 gonad of a male animal, produces and releases sperm. Either of paired male reproductive organs which are involved in the production of sperm and male sex hormones.[AAO] Male reproductive organ.[TAO] (...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG] testicular The testes are descended in metatherian and eutherian mammals. UBERON:0002117 AAO:0000606 BILA:0000124 BSA:0000085 BTO:0001363 CALOHA:TS-1030 EFO:0000984 EHDAA2:0002007 EHDAA:8146 EMAPA:17972 EV:0100102 FBbt:00004928 FMA:7210 GAID:396 HAO:0001007 MA:0000411 MAT:0000132 MESH:A05.360.444.849 MIAA:0000132 OpenCyc:Mx4rvVjM25wpEbGdrcN5Y29ycA TAO:0000598 UMLS:C0039597 VHOG:0000252 WBbt:0006794 XAO:0000157 ZFA:0000598 galen:Testis ncithesaurus:Testis genitalia of male organism gonad genitalia of male organism gonada gonad of genitalia of male organism gonad of male genitalia gonad of male genitals gonad of male organism genitalia gonad of male organism reproductive system gonad of male reproductive system gonad of reproductive system of male organism gonada of genitalia of male organism gonada of male genitalia gonada of male genitals gonada of male organism genitalia gonada of male organism reproductive system gonada of male reproductive system gonada of reproductive system of male organism male genitalia gonad male genitalia gonada male genitals gonad male gonad male organism genitalia gonad male organism genitalia gonada male organism reproductive system gonad male organism reproductive system gonada male reproductive system gonad male reproductive system gonada reproductive system of male organism gonad reproductive system of male organism gonada testicle uberon orchis testes testiculus UBERON:0000473 testis UBERON:0000473 An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium. Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO] It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG] AAO:0000579 ANISEED:1235297 BTO:0001307 CALOHA:TS-0980 EFO:0000837 EHDAA2:0001915 EHDAA:2993 EMAPA:17021 EMAPA:18889 EV:0100070 FMA:7148 GAID:293 MA:0000353 MAT:0000051 MESH:A03.492.766 MIAA:0000051 OpenCyc:Mx4rvVjlqpwpEbGdrcN5Y29ycA TAO:0002121 UMLS:C0038351 VHOG:0000408 XAO:0000128 galen:Stomach ncithesaurus:Stomach stomach chamber uberon Ventricular anterior intestine gaster mesenteron ventriculus UBERON:0000945 Taxon notes: We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa [WP:Stomach#In_other_animals] stomach UBERON:0000945 The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO] Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO] The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO) (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] AAO:0010478 ABA:Brain BAMS:Br BAMS:Brain BILA:0000135 BTO:0000142 CALOHA:TS-0095 EFO:0000302 EHDAA2:0000183 EHDAA:2641 EHDAA:6485 EMAPA:16894 EV:0100164 FBbt:00005095 FMA:50801 GAID:571 MA:0000168 MAT:0000098 MESH:A08.186.211 MIAA:0000098 NIF_GrossAnatomy:birnlex_796 NeuroNames:21 OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA TAO:0000008 UMLS:C0006104 UMLS:C1269537 VHOG:0000157 XAO:0000010 ZFA:0000008 galen:Brain ncithesaurus:Brain uberon encephalon suprasegmental levels of nervous system suprasegmental structures synganglion the brain UBERON:0000955 include synganglion? brain UBERON:0000955 Ovum-producing female reproductive organ. Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO] Female reproductive organ.[TAO] relationship type change: subclass gonad (TAO:0000413) CHANGED TO: develops_from gonad (UBERON:0000991)[TAO] (...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG] ovarian AAO:0000371 BILA:0000125 BSA:0000080 BTO:0000975 CALOHA:TS-0730 EFO:0000973 EHDAA2:0001360 EHDAA:8124 EMAPA:17962 EV:0100111 FBbt:00004865 FMA:7209 GAID:367 MA:0000384 MESH:A05.360.319.114.630 MIAA:0000125 OpenCyc:Mx4rvVi9QJwpEbGdrcN5Y29ycA TAO:0000403 UMLS:C0029939 VHOG:0000251 XAO:0000258 ZFA:0000403 ncithesaurus:Ovary female organism genitalia gonad female organism genitalia gonada female organism reproductive system gonad female organism reproductive system gonada female reproductive system gonad female reproductive system gonada genitalia of female organism gonad genitalia of female organism gonada gonad of female organism genitalia gonad of female organism reproductive system gonad of female reproductive system gonad of genitalia of female organism gonad of reproductive system of female organism gonada of female organism genitalia gonada of female organism reproductive system gonada of female reproductive system gonada of genitalia of female organism gonada of reproductive system of female organism ovary ovum-producing ovary reproductive system of female organism gonad reproductive system of female organism gonada uberon ovaries ovarium UBERON:0000992 Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous. Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity. Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct. Although most normal female vertebrates have two ovaries, this is not the case in all species. In birds and platypuses, the right ovary never matures, so that only the left is functional. In some elasmobranchs, the reverse is true, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo[WP]. female gonad UBERON:0000992 a major female hormone-responsive reproductive sex organ of most mammals including humans. One end, the cervix, opens into the vagina, while the other is connected to one or both fallopian tubes, depending on the species. It is within the uterus that the fetus develops during gestation, usually developing completely in placental mammals such as humans and partially in marsupials such as kangaroos and opossums. Two uteruses usually form initially in a female fetus, and in placental mammals they may partially or completely fuse into a single uterus depending on the species. In many species with two uteruses, only one is functional. Humans and other higher primates such as chimpanzees, along with horses, usually have a single completely fused uterus, although in some individuals the uteruses may not have completely fused[WP]. The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG] An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG] uterine BTO:0001424 CALOHA:TS-1102 EFO:0000975 EMAPA:29915 EV:0100113 FMA:17558 GAID:172 MA:0000389 MAT:0000127 MESH:A05.360.319.679 MIAA:0000127 OpenCyc:Mx4rvViojJwpEbGdrcN5Y29ycA UMLS:C0042149 VHOG:0001137 galen:Uterus ncithesaurus:Uterus uberon UBERON:0000995 Most animals that lay eggs, such as birds and reptiles, have an oviduct instead of a uterus. In monotremes, mammals which lay eggs and include the platypus, either the term uterus or oviduct is used to describe the same organ, but the egg does not develop a placenta within the mother and thus does not receive further nourishment after formation and fertilization. Marsupials have two uteruses, each of which connect to a lateral vagina and which both use a third, middle "vagina" which functions as the birth canal. Marsupial embryos form a choriovitelline "placenta" (which can be thought of as something between a monotreme egg and a "true" placenta), in which the egg's yolk sac supplies a large part of the embryo's nutrition but also attaches to the uterine wall and takes nutrients from the mother's bloodstream. uterus UBERON:0000995 external genital organs of the female mammal[WP]. The external genital organs of the female, including the labia majora, labia minora, clitoris, and vestibule of the vagina. [TFD][VHOG] vulval BTO:0003101 CALOHA:TS-1168 EFO:0000978 EV:0100118 FMA:20462 GAID:383 MA:0000395 MAT:0000169 MESH:A05.360.319.887 MIAA:0000169 OpenCyc:Mx4rvgAWeJwpEbGdrcN5Y29ycA UMLS:C0042993 VHOG:0001458 galen:Vulva ncithesaurus:Vulva female pudendum mammalian vulva puboperineal region pudendum femininum skin of female pudendum skin of vulva vulva uberon pudendum pudendum femininum pudendum muliebre UBERON:0000997 editor note: todo - add pudendum mammalian vulva UBERON:0000997 The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO] Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO] relationship type change: differentiates_from ectoderm (AAO:0000137) CHANGED TO: develops_from ectoderm (UBERON:0000924)[AAO] Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG] nervous neural AAO:0000324 BILA:0000079 BTO:0001484 CALOHA:TS-1313 EFO:0000802 EHDAA2:0001246 EHDAA:826 EMAPA:16469 EV:0100162 FBbt:00005093 FMA:7157 GAID:466 MA:0000016 MAT:0000026 MESH:A08 MIAA:0000026 NIF_GrossAnatomy:birnlex_844 NeuroNames:3236 OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA TAO:0000396 UMLS:C0027763 VHOG:0000402 WBbt:0005735 XAO:0000177 ZFA:0000396 ncithesaurus:Nervous_System nerve net uberon Nervensystem systema nervosum UBERON:0001016 nervous system UBERON:0001016 Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO] The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG] esophageal AAO:0000145 ANISEED:1235301 BTO:0000959 CALOHA:TS-0700 EFO:0000835 EHDAA2:0001285 EHDAA:2937 EMAPA:16833 EMAPA:18860 EV:0100069 FMA:7131 GAID:291 MA:0000352 MAT:0000048 MESH:A03.365 MIAA:0000048 OpenCyc:Mx4rvVj9Q5wpEbGdrcN5Y29ycA TAO:0000204 UMLS:C0014876 VHOG:0000450 XAO:0000127 ZFA:0000204 galen:Esophagus ncithesaurus:Esophagus gullet oesophagus uberon œsophagus UBERON:0001043 AO notes: esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995) esophagus UBERON:0001043 Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. AAO:0010841 AEO:0000000 BILA:0000000 CARO:0000000 EHDAA2:0002229 FBbt:10000000 FBbt_root:00000000 FMA:62955 HAO:0000000 MA:0000001 NIF_GrossAnatomy:birnlex_6 TAO:0100000 TGMA:0001822 UMLS:C1515976 ZFA:0100000 ncithesaurus:Anatomic_Structure_System_or_Substance uberon UBERON:0001062 anatomical entity UBERON:0001062 distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]. A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] Anatomical structure which consists of a membranous sac used to temporarily store urine until it is excreted from the body.[AAO] In tetrapods, the urinary bladder arises as an outpocketing of the cloaca. (...) The tetrapod urinary bladder appears first among amphibians and is present in Sphenodon, turtles, most lizards, ostriches among birds, and all mammals.[well established][VHOG] vesical AAO:0000623 BTO:0001418 CALOHA:TS-1090 EFO:0000290 EHDAA2:0000174 EHDAA:9328 EMAPA:18321 EV:0100098 FMA:15900 GAID:0000004 MA:0000380 MAT:0000122 MESH:A05.810.161 MIAA:0000122 OpenCyc:Mx4rvVjMmZwpEbGdrcN5Y29ycA UMLS:C0005682 VHOG:0000740 XAO:0000154 galen:UrinaryBladder ncithesaurus:Bladder bladder vesica urinaria uberon urocyst vesica UBERON:0001255 urinary bladder UBERON:0001255 An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1–2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans[PMID]. Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO] In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] pancreatic AAO:0010112 BTO:0000988 CALOHA:TS-0736 EFO:0000855 EHDAA2:0001367 EHDAA:6893 EMAPA:17503 EMAPA:18816 EV:0100092 FMA:7198 GAID:334 MA:0000120 MAT:0000075 MESH:A03.734 MIAA:0000075 OpenCyc:Mx4rvVimZZwpEbGdrcN5Y29ycA TAO:0000140 UMLS:C0030274 VHOG:0000050 XAO:0000136 ZFA:0000140 galen:Pancreas ncithesaurus:Pancreas uberon UBERON:0001264 taxon notes: As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52) [PMID:20959416]. The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract (Figures 16 and 17 ). The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm pancreas UBERON:0001264 Skeletal element that is composed of bone tissue. Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO] Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO] Skeletal element that is composed of bone tissue.[VSAO] relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG] AAO:0000047 AEO:0000082 BTO:0000140 CALOHA:TS-0088 EFO:0000298 EHDAA2:0003082 EMAPA:32782 ENVO:00002039 EV:0100140 FMA:30317 FMA:5018 GAID:92 MA:0001459 MAT:0000299 MIAA:0000299 OpenCyc:Mx4rvViDlpwpEbGdrcN5Y29ycA OpenCyc:Mx4rvVkCG5wpEbGdrcN5Y29ycA TAO:0001514 UMLS:C0262950 VHOG:0001190 VSAO:0000057 XAO:0000169 ZFA:0001514 galen:Bone ncithesaurus:Bone bone element bone organ uberon bone UBERON:0001474 Alternate definition: Organ with cavitated organ parts, which primarily consists of compact (cortical) and cancellous bone, which surround bone marrow cavities; together with other bones, cartilages and joints, it constitutes the skeletal system. Examples: femur, sternum, maxilla, vertebra, talus[FMA] bone element UBERON:0001474 Body substance in liquid state contained in the lumen of arterial and venous trees, blood capillary and the cardiac chambers; constitutes the liquid phase of blood.[FMA] BTO:0000131 CALOHA:TS-0800 EFO:0001905 FMA:62970 GAID:1178 MA:0002501 MAT:0000052 MESH:A12.207.152.693 MIAA:0000052 OpenCyc:Mx4rEg4ZYrIbEduAAAAOpmP6tw UMLS:C0032105 ncithesaurus:Plasma plasma portion of blood plasma portion of plasma uberon UBERON:0001969 blood plasma UBERON:0001969 A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]. Either of paired structures located in the throat which develop from the ventral wall of the pharynx and excretes hormones involved in the morphological and functional changes during metamorphosis as well as influencing other tissues.[AAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (2) a groove in the pharyngeal floor known as the endostyle, or a thyroid gland derived from part of the endostyle (...).[well established][VHOG] In fish, it is usually located below the gills and is not always divided into distinct lobes. However, in some teleosts, patches of thyroid tissue are found elsewhere in the body, associated with the kidneys, spleen, heart, or eyes In larval lampreys, the thyroid originates as an exocrine gland, secreting its hormones into the gut, and associated with the larva's filter-feeding apparatus. In the adult lamprey, the gland separates from the gut, and becomes endocrine, but this path of development may reflect the evolutionary origin of the thyroid. For instance, the closest living relatives of vertebrates, the tunicates and Amphioxus, have a structure very similar to that of larval lampreys, and this also secretes iodine-containing compounds (albeit not thyroxine) In tetrapods, the thyroid is always found somewhere in the neck region. In most tetrapod species, there are two paired thyroid glands - that is, the right and left lobes are not joined together. However, there is only ever a single thyroid gland in most mammals, and the shape found in humans is common to many other species AAO:0010544 BTO:0001379 CALOHA:TS-1047 EFO:0000861 EHDAA2:0002028 EHDAA:2148 EHDAA:2975 EMAPA:17068 EMAPA:18827 EV:0100133 FMA:9603 GAID:465 MA:0000129 MAT:0000081 MESH:A06.407.900 MIAA:0000081 OpenCyc:Mx4rvVjLT5wpEbGdrcN5Y29ycA UMLS:C0040132 VHOG:0000418 XAO:0000162 galen:ThyroidGland ncithesaurus:Thyroid_Gland thyroid uberon glandula thyroidea UBERON:0002046 thyroid gland UBERON:0002046 Respiration organ present in all air-breathing animals whose principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere[WP]. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax[GO]. Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO] Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG] pulmonary AAO:0000275 AAO:0010567 BTO:0000763 CALOHA:TS-0568 EFO:0000934 EHDAA2:0001042 EHDAA:1554 EHDAA:2205 EMAPA:16728 EV:0100042 FMA:7195 GAID:345 MA:0000415 MAT:0000135 MESH:A04.411 MIAA:0000135 OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA UMLS:C0024109 VHOG:0000310 XAO:0000119 galen:Lung ncithesaurus:Lung pulmo uberon UBERON:0002048 respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi // Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] lung UBERON:0002048 Nonparenchymatous organ that consists of the dermis and epidermis. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body.[FMA]. BTO:0001253 CALOHA:TS-0934 EFO:0000962 EHDAA2:0001844 EMAPA:17525 FMA:7163 MESH:A17.815 OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA UMLS:C1123023 XAO:0000023 galen:Skin ncithesaurus:Skin entire skin uberon integument pelt skin UBERON:0002097 Usage notes: consider 'integumentary system' for invertebrates. AO notes: Note that FMA uses 'skin' for the entire organ. XAO seems consistent. MA seems to use it analagously to zone of skin skin of body UBERON:0002097 An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. Organ which secretes bile and participates in formation of certain blood proteins.[AAO] relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO] All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG] hepatic AAO:0010111 BTO:0000759 CALOHA:TS-0564 EFO:0000887 EHDAA2:0000997 EHDAA:2197 EMAPA:16846 EV:0100089 FMA:7197 GAID:288 MA:0000358 MAT:0000097 MESH:A03.620 MIAA:0000097 OpenCyc:Mx4rvVimppwpEbGdrcN5Y29ycA TAO:0000123 UMLS:C0023884 VHOG:0000257 XAO:0000133 ZFA:0000123 galen:Liver ncithesaurus:Liver uberon iecur jecur UBERON:0002107 AO notes: Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function. Taxon notes: WP: The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates.[7] An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. // The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003). liver UBERON:0002107 a small organ that aids digestion and stores bile produced by the liver[WP]. Organ with organ cavity which is continuous proximally with the cystic duct and distally terminates in the fundus of the gallbladder[FMA]. Membranous muscular sac in which the bile from the liver remains stored until it is required. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] Organ attached to the liver which stores bile and empties into the duodenum via the bile duct as needed for digestion.[AAO] relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO] The presence of a gallbladder appears to be a primitive trait. It is found in most fish and all adult reptiles and amphibians and has been well conserved in mammals, for the most part.[well established][VHOG] AAO:0010114 BTO:0000493 CALOHA:TS-0394 EFO:0000853 EHDAA2:0000699 EHDAA:8062 EMAPA:17202 EV:0100090 FMA:7202 MA:0000356 MAT:0000072 MESH:A03.159.439 MIAA:0000072 OpenCyc:Mx4rvVkGr5wpEbGdrcN5Y29ycA TAO:0000208 UMLS:C0016976 VHOG:0000221 XAO:0000135 ZFA:0000208 galen:Gallbladder ncithesaurus:Gallbladder gall bladder uberon vesica fellea; vesica biliaris UBERON:0002110 Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988) gallbladder UBERON:0002110 A paired organ which has the production of urine as its primary function. One of either of a pair of structures lying on either side of the dorsal aorta in which fluid balance is regulated and waste is excreted out in the form of urine.[AAO] renal AAO:0000250 BTO:0000671 CALOHA:TS-0510 EFO:0000929 EV:0100096 FMA:7203 GAID:423 MA:0000368 MAT:0000119 MESH:A05.810.453 MIAA:0000119 OpenCyc:Mx4rvVjlYpwpEbGdrcN5Y29ycA UMLS:C0022646 XAO:0003267 galen:Kidney ncithesaurus:Kidney reniculate kidney uberon UBERON:0002113 kidney UBERON:0002113 The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] duodenal In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum. In humans, the duodenum is a hollow jointed tube about 10–15 inches (25–38 centimetres) long connecting the stomach to the jejunum. It begins with the duodenal bulb and ends at the ligament of Treitz. AAO:0010402 BTO:0000365 CALOHA:TS-0214 EFO:0000851 EMAPA:18852 EV:0100073 FMA:7206 GAID:284 MA:0000338 MAT:0000044 MESH:A03.492.411.620.270 MIAA:0000044 OpenCyc:Mx4rv4LJDpwpEbGdrcN5Y29ycA UMLS:C0013303 VHOG:0000052 XAO:0000236 galen:Duodenum ncithesaurus:Duodenum uberon proximal intestine upper intestine UBERON:0002114 duodenum UBERON:0002114 The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. prostatic BTO:0001129 CALOHA:TS-0828 EFO:0000858 EMAPA:19287 EV:0100104 FMA:9600 GAID:392 MA:0000404 MAT:0000078 MESH:A05.360.444.575 MIAA:0000078 OpenCyc:Mx4rv6trqZwpEbGdrcN5Y29ycA UMLS:C0033572 VHOG:0001261 galen:ProstateGland ncithesaurus:Prostate_Gland male prostate prostate uberon prostata UBERON:0002367 TODO - FMA treats the gland as part of the prostate - see also FMA:74119. prostate gland UBERON:0002367 Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]. Anatomical structure which is found on the surface of the kidney and secretes various hormones including epinephrine, norephinephrine, aldosterone, corticosterone, and cortisol.[AAO] All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG] AAO:0010551 BTO:0000047 CALOHA:TS-0016 EFO:0000238 EMAPA:18426 EV:0100135 FMA:9604 GAID:446 MA:0000116 MAT:0000071 MESH:A06.407.071 MIAA:0000071 OpenCyc:Mx4rvXYiz5wpEbGdrcN5Y29ycA UMLS:C0001625 VHOG:0001141 XAO:0000164 galen:AdrenalGland ncithesaurus:Adrenal_Gland glandula adrenalis glandula suprarenalis uberon adrenal adrenal capsule adrenal medulla cell atrabiliary capsule epinephric gland epinephros glandula suprarenalis interrenal gland suprarenal capsule suprarenal gland UBERON:0002369 Taxon notes: The origin of the adrenal gland is still controversial. It is thought to share the same origin as the kidney and gonads, derived from coelomic epithelium of the urogenital ridge and/or the underlying mesenchyme (Keegan and Hammer, 2002; Morohashi, 1997). We follow Kardong and state homology at the level of the cortex and medulla rather than gland as a whole adrenal gland UBERON:0002369 Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO] AAO:0000306 AEO:0000122 CALOHA:TS-0642 EHDAA2:0003122 FMA:9641 MA:0002437 MESH:A02.633 UMLS:C2328219 galen:MuscleTissue ncithesaurus:Muscle_Tissue muscular tissue portion of muscle tissue textus muscularis uberon UBERON:0002385 Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. muscle tissue UBERON:0002385 The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. CALOHA:TS-2356 EV:0100009 FMA:280881 MA:0000006 UMLS:C0460004 WikipediaCategory:Head_and_neck galen:HeadAndNeck ncithesaurus:Head_and_Neck uberon cephalic area cephalic part of animal cephalic region head and neck head or neck UBERON:0007811 craniocervical region UBERON:0007811 dto:DTO_00000001 A ligand that interacts or binds with a G-protein coupled receptor protein. GPCR ligand dto:DTO_00000002 Any amino acid residue of the kinase that is annotated as a gatekeeper. A gatekeeper residue is a residue that partially or fully blocks a hydrophobic region deep in the ATP binding pocket of a kinase. gatekeeper role dto:DTO_00000003 An Endogenous ligand is a molecule like protein, lipid, nucleoside, etc., that is produced in the body and that attaches (binds) to another protein called a receptor; receptor proteins have specific sites into which the ligands fit like keys into locks. Endogenous ligands not those that are introduced into the body, such as certain drugs. https://ghr.nlm.nih.gov/primer/genefamily/endogenousligands Endogenous ligand role dto:DTO_00000004 A material entity, such as native (gene product) protein, protein complex, microorganism, DNA , etc., that physically interacts with a therapeutic or prophylactic drug (with some binding affinity) and where this physical interaction is (at least partially) the cause of a (detectable) clinical effect. Tudor Oprea, Stephan Schurer, Asiyah Yu Lin drug target http://drugcentral.org/ dto:DTO_00000005 Tclin are proteins targeted by approved drugs as they exert their mode of action. Drug targets are entities with molecular mass present in living systems that, upon interaction with therapeutic agents or their byproducts, result in modified biologic responses that lead to therapeutic outcomes. Here “living systems” encompass humans or animals (e.g., for veterinary medicines) and foreign organisms such as viruses, bacteria or parasites that may be infest humans or animals. The interaction between a drug and its target results in observable clinical outcomes. For drug targets, “mode of action” (MoA), referred to as “mechanism of action” when the molecular interactions are well understood, describes the way in which drugs exert their intended therapeutic action, resulting in the intended therapeutic outcome, i.e., the indication(s) stated on the approved drug label, or otherwise the desired outcome (for off-label usage). Some drug-target interactions may lead to unintended clinical outcomes, i.e., side effects or adverse drug reactions. While side effects can be mediated by MoA targets, they are often the result of the interaction between the drug or its metabolites and other proteins. (resource: IDG) IDG; http://www.nature.com/nrd/posters/druggablegenome/nrd_druggablegenome.pdf Tclin drug target dto:DTO_00000006 Tchem are proteins that can specifically be manipulated with small molecules better than bioactivity cutoff values (30 nM for kinases, 100 nM for GPCRs and NRs, 10 uM for ICs, and 1 uM for other target classes), which lack approved small molecule or biologic drugs. In some cases, targets have been manually migrated to Tchem through human curation, based on small molecule activities from sources other than ChEMBL or Drug Central. IDG; http://www.nature.com/nrd/posters/druggablegenome/nrd_druggablegenome.pdf Tchem protein dto:DTO_00000007 Tbio are proteins that do not satisfy the Tclin or Tchem criteria, which are annotated with a Gene Ontology Molecular Function or Biological Process with an Experimental Evidence code, or targets with confirmed OMIM phenotype(s), or do not satisfy the Tdark drug target criteria. IDG; http://www.nature.com/nrd/posters/druggablegenome/nrd_druggablegenome.pdf Tbio protein dto:DTO_00000008 Tdark refers to proteins that have been described at the sequence level and have very few associated studies. They do not have any known drug or small molecule activities that satisfy the activity thresholds detailed in 2), lack OMIM and GO terms that would match Tbio criteria, and meet at least two of the following conditions: 1)A PubMed text-mining score < 5; 2) < = 3 Gene RIFs; 3)<= 50 Antibodies available according to http://antibodypedia.com IDG; http://www.nature.com/nrd/posters/druggablegenome/nrd_druggablegenome.pdf Tdark protein dto:DTO_00000009 a role that is beared in a material entity, such as native (gene product) protein, protein complex, microorganism, DNA , etc., that physically interacts with a therapeutic or prophylactic drug (with some binding affinity) and where this physical interaction is (at least partially) the cause of a (detectable) clinical effect. Tudor Oprea, Stephan Schurer, Asiyah Yu Lin drug target role http://drugcentral.org/ dto:DTO_00000010 A GPCR ligand that is classified as amine in CHEBI. Asiyah Yu Lin amine GPCR ligand dto:DTO_00000011 A GPCR ligand that is classified as amino acid in CHEBI. Asiyah Yu Lin amino acid GPCR ligand dto:DTO_00000012 A GPCR ligand that is classified as carboxylic acid in CHEBI. Asiyah Yu Lin carboxylic acid GPCR ligand dto:DTO_00000013 A GPCR ligand that is classified as inorganic ion in CHEBI. Asiyah Yu Lin inorganic ion GPCR ligand dto:DTO_00000014 A GPCR ligand that is classified as lipid in CHEBI. Asiyah Yu Lin lipid GPCR ligand dto:DTO_00000015 A GPCR ligand that is classified as nucleoside in CHEBI. Asiyah Yu Lin nucleoside GPCR ligand dto:DTO_00000016 A GPCR ligand that is classified as nucleotide in CHEBI. Asiyah Yu Lin nucleotide GPCR ligand dto:DTO_00000017 A GPCR ligand that is classified as peptide in CHEBI. Asiyah Yu Lin peptide GPCR ligand An umbrella term created for tissues and cell lines imported from BRENDA ontology. BRENDA tissues and cell lines dto:DTO_00102000 Nuclear hormone receptor proteins form a class of ligand activated proteins that, when bound to specific sequences of DNA serve as on-off switches for transcription within the cell nucleus. These switches control the development and differentiation of skin, bone and behavioral centers in the brain, as well as the continual regulation of reproductive tissues. http://www.ks.uiuc.edu/Research/pro_DNA/ster_horm_rec/ Nuclear hormone receptor dto:DTO_00117459 Dax-like receptors dto:DTO_00117460 Thyroid hormone receptors dto:DTO_00117461 Retinoic acid receptors dto:DTO_00117462 Peroxisome proliferator-activated receptors dto:DTO_00117463 Rev-erb receptors dto:DTO_00117464 Retinoic acid-related orphans dto:DTO_00117465 Liver x receptor-like receptors dto:DTO_00117466 Vitamin d receptor-like receptors dto:DTO_00117467 Hepatocyte nuclear factor-4 receptors dto:DTO_00117468 Retinoid x receptors dto:DTO_00117469 Testicular receptors dto:DTO_00117470 Tailless-like receptors dto:DTO_00117471 Coup-tf-like receptors dto:DTO_00117472 Estrogen receptors dto:DTO_00117473 Estrogen-related receptors dto:DTO_00117474 3-ketosteroid receptors dto:DTO_00117475 Nerve growth factor ib-like receptors dto:DTO_00117476 Fushi tarazu f1-like receptors dto:DTO_00117477 Germ cell nuclear factor receptors dto:DTO_00117478 A nuclear receptor subfamily 0 group B member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51843] https://pharos.nih.gov/idg/targets/P51843 NR0B1 DAX1 P51843 Nuclear receptor subfamily 0 group b member 1 dto:DTO_00117479 A nuclear receptor subfamily 0 group B member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15466] https://pharos.nih.gov/idg/targets/Q15466 NR0B2 Q15466 Nuclear receptor subfamily 0 group b member 2 dto:DTO_00117480 A thyroid hormone receptor alpha that is encoded in the genome of human. [PRO:HJD, UniProtKB:P10827] https://pharos.nih.gov/idg/targets/P10827 THRA ERBA1 P10827 Thyroid hormone receptor alpha dto:DTO_00117481 A thyroid hormone receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10828] https://pharos.nih.gov/idg/targets/P10828 THRB NR1A2 P10828 Thyroid hormone receptor beta dto:DTO_00117482 A retinoic acid receptor alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10276] https://pharos.nih.gov/idg/targets/P10276 RARA P10276 Retinoic acid receptor alpha dto:DTO_00117483 A retinoic acid receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10826] https://pharos.nih.gov/idg/targets/P10826 RARB NR1B2 P10826 Retinoic acid receptor beta dto:DTO_00117484 A retinoic acid receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13631] https://pharos.nih.gov/idg/targets/P13631 RARG P13631 Retinoic acid receptor gamma dto:DTO_00117485 A peroxisome proliferator-activated receptor alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07869] https://pharos.nih.gov/idg/targets/Q07869 PPARA PPAR Q07869 Peroxisome proliferator-activated receptor alpha dto:DTO_00117486 A peroxisome proliferator-activated receptor delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03181] https://pharos.nih.gov/idg/targets/Q03181 PPARD PPARB Q03181 Peroxisome proliferator-activated receptor delta dto:DTO_00117487 A peroxisome proliferator-activated receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37231] https://pharos.nih.gov/idg/targets/P37231 PPARG P37231 Peroxisome proliferator-activated receptor gamma dto:DTO_00117488 A nuclear receptor subfamily 1 group D member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20393] https://pharos.nih.gov/idg/targets/P20393 NR1D1 HREV P20393 Nuclear receptor subfamily 1 group d member 1 dto:DTO_00117489 A nuclear receptor subfamily 1 group D member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14995] https://pharos.nih.gov/idg/targets/Q14995 NR1D2 Q14995 Nuclear receptor subfamily 1 group d member 2 dto:DTO_00117490 A nuclear receptor ROR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35398] https://pharos.nih.gov/idg/targets/P35398 RORA RZRA P35398 Nuclear receptor ror-alpha dto:DTO_00117491 A nuclear receptor ROR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92753] https://pharos.nih.gov/idg/targets/Q92753 RORB RZRB Q92753 Nuclear receptor ror-beta dto:DTO_00117492 A nuclear receptor ROR-gamma that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51449] https://pharos.nih.gov/idg/targets/P51449 RORC RORG P51449 Nuclear receptor ror-gamma dto:DTO_00117493 A bile acid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RI1] https://pharos.nih.gov/idg/targets/Q96RI1 NR1H4 FXR Q96RI1 Bile acid receptor dto:DTO_00117494 An oxysterols receptor LXR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13133] https://pharos.nih.gov/idg/targets/Q13133 NR1H3 Q13133 Oxysterols receptor lxr-alpha dto:DTO_00117495 An oxysterols receptor LXR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55055] https://pharos.nih.gov/idg/targets/P55055 NR1H2 NER P55055 Oxysterols receptor lxr-beta dto:DTO_00117496 A vitamin D3 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11473] https://pharos.nih.gov/idg/targets/P11473 VDR P11473 Vitamin d3 receptor dto:DTO_00117497 A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75469] https://pharos.nih.gov/idg/targets/O75469 NR1I2 O75469 Nuclear receptor subfamily 1 group i member 2 dto:DTO_00117498 A nuclear receptor subfamily 1 group I member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14994] https://pharos.nih.gov/idg/targets/Q14994 NR1I3 Q14994 Nuclear receptor subfamily 1 group i member 3 dto:DTO_00117499 A hepatocyte nuclear factor 4-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41235] https://pharos.nih.gov/idg/targets/P41235 HNF4A NR2A1 P41235 Hepatocyte nuclear factor 4-alpha dto:DTO_00117500 A hepatocyte nuclear factor 4-gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14541] https://pharos.nih.gov/idg/targets/Q14541 HNF4G Q14541 Hepatocyte nuclear factor 4-gamma dto:DTO_00117501 A retinoic acid receptor RXR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19793] https://pharos.nih.gov/idg/targets/P19793 RXRA P19793 Retinoic acid receptor rxr-alpha dto:DTO_00117502 A retinoic acid receptor RXR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28702] https://pharos.nih.gov/idg/targets/P28702 RXRB P28702 Retinoic acid receptor rxr-beta dto:DTO_00117503 A retinoic acid receptor RXR-gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48443] https://pharos.nih.gov/idg/targets/P48443 RXRG P48443 Retinoic acid receptor rxr-gamma dto:DTO_00117504 A nuclear receptor subfamily 2 group C member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13056] https://pharos.nih.gov/idg/targets/P13056 NR2C1 P13056 Nuclear receptor subfamily 2 group c member 1 dto:DTO_00117505 A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49116] https://pharos.nih.gov/idg/targets/P49116 NR2C2 TR4 P49116 Nuclear receptor subfamily 2 group c member 2 dto:DTO_00117506 A nuclear receptor subfamily 2 group E member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y466] https://pharos.nih.gov/idg/targets/Q9Y466 NR2E1 Q9Y466 Nuclear receptor subfamily 2 group e member 1 dto:DTO_00117507 A photoreceptor-specific nuclear receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5X4] https://pharos.nih.gov/idg/targets/Q9Y5X4 NR2E3 RNR Q9Y5X4 Photoreceptor-specific nuclear receptor dto:DTO_00117508 A COUP transcription factor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10589] https://pharos.nih.gov/idg/targets/P10589 NR2F1 ERBAL3 P10589 Coup transcription factor 1 dto:DTO_00117509 A COUP transcription factor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24468] https://pharos.nih.gov/idg/targets/P24468 NR2F2 TFCOUP2 P24468 Coup transcription factor 2 dto:DTO_00117510 A nuclear receptor subfamily 2 group F member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10588] https://pharos.nih.gov/idg/targets/P10588 NR2F6 ERBAL2 P10588 Nuclear receptor subfamily 2 group f member 6 dto:DTO_00117511 An estrogen receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P03372] https://pharos.nih.gov/idg/targets/P03372 ESR1 NR3A1 P03372 Estrogen receptor dto:DTO_00117512 An estrogen receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92731] https://pharos.nih.gov/idg/targets/Q92731 ESR2 NR3A2 Q92731 Estrogen receptor beta dto:DTO_00117513 A steroid hormone receptor ERR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11474] https://pharos.nih.gov/idg/targets/P11474 ESRRA ESRL1 P11474 Steroid hormone receptor err1 dto:DTO_00117514 A steroid hormone receptor ERR2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95718] https://pharos.nih.gov/idg/targets/O95718 ESRRB ESRL2 O95718 Steroid hormone receptor err2 dto:DTO_00117515 An estrogen-related receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62508] https://pharos.nih.gov/idg/targets/P62508 ESRRG ERRG2 P62508 Estrogen-related receptor gamma dto:DTO_00117516 An androgen receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10275] https://pharos.nih.gov/idg/targets/P10275 AR NR3C4 P10275 Androgen receptor dto:DTO_00117517 A glucocorticoid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04150] https://pharos.nih.gov/idg/targets/P04150 NR3C1 P04150 Glucocorticoid receptor dto:DTO_00117518 A mineralocorticoid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08235] https://pharos.nih.gov/idg/targets/P08235 NR3C2 MLR P08235 Mineralocorticoid receptor dto:DTO_00117519 A progesterone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06401] https://pharos.nih.gov/idg/targets/P06401 PGR P06401 Progesterone receptor dto:DTO_00117520 A nuclear receptor subfamily 4 group A member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22736] https://pharos.nih.gov/idg/targets/P22736 NR4A1 HMR P22736 Nuclear receptor subfamily 4 group a member 1 dto:DTO_00117521 A nuclear receptor subfamily 4 group A member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43354] https://pharos.nih.gov/idg/targets/P43354 NR4A2 NURR1 P43354 Nuclear receptor subfamily 4 group a member 2 dto:DTO_00117522 A nuclear receptor subfamily 4 group A member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92570] https://pharos.nih.gov/idg/targets/Q92570 NR4A3 CSMF Q92570 Nuclear receptor subfamily 4 group a member 3 dto:DTO_00117523 A steroidogenic factor 1 that is encoded in the genome of human. [PRO:CNA] https://pharos.nih.gov/idg/targets/Q13285 NR5A1 FTZF1 Q13285 Steroidogenic factor 1 dto:DTO_00117524 A nuclear receptor subfamily 5 group A member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00482] https://pharos.nih.gov/idg/targets/O00482 NR5A2 CPF O00482 Nuclear receptor subfamily 5 group a member 2 dto:DTO_00117525 A nuclear receptor subfamily 6 group A member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15406] https://pharos.nih.gov/idg/targets/Q15406 NR6A1 Q15406 Nuclear receptor subfamily 6 group a member 1 dto:DTO_00200000 A genomic sequence, which is the unit of heredity of a living organism. It consists of regulatory regions and transcribed regions. Gene dto:DTO_00200002 Nuclear hormone receptor proteins form a class of ligand activated proteins that, when bound to specific sequences of DNA serve as on-off switches for transcription within the cell nucleus. These switches control the development and differentiation of skin, bone and behavioral centers in the brain, as well as the continual regulation of reproductive tissues. http://www.ks.uiuc.edu/Research/pro_DNA/ster_horm_rec/ Nuclear hormone receptor gene dto:DTO_00217459 Dax-like receptors gene dto:DTO_00217460 Thyroid hormone receptors gene dto:DTO_00217461 Retinoic acid receptors gene dto:DTO_00217462 Peroxisome proliferator-activated receptors gene dto:DTO_00217463 Rev-erb receptors gene dto:DTO_00217464 Retinoic acid-related orphans gene dto:DTO_00217465 Liver x receptor-like receptors gene dto:DTO_00217466 Vitamin d receptor-like receptors gene dto:DTO_00217467 Hepatocyte nuclear factor-4 receptors gene dto:DTO_00217468 Retinoid x receptors gene dto:DTO_00217469 Testicular receptors gene dto:DTO_00217470 Tailless-like receptors gene dto:DTO_00217471 Coup-tf-like receptors gene dto:DTO_00217472 Estrogen receptors gene dto:DTO_00217473 Estrogen-related receptors gene dto:DTO_00217474 3-ketosteroid receptors gene dto:DTO_00217475 Nerve growth factor ib-like receptors gene dto:DTO_00217476 Fushi tarazu f1-like receptors gene dto:DTO_00217477 Germ cell nuclear factor receptors gene dto:DTO_00217528 This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008] 190 NR0B1 AHC DAX1 NR0B1 gene dto:DTO_00217529 The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008] 8431 NR0B2 SHP NR0B2 gene dto:DTO_00217530 The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] 7067 THRA EAR7 ERBA1 NR1A1 THRA gene dto:DTO_00217531 The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008] 7068 THRB ERBA2 NR1A2 THR1 THRB gene dto:DTO_00217532 This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010] 5914 RARA NR1B1 RARA gene dto:DTO_00217533 This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014] 5915 RARB HAP NR1B2 RARB gene dto:DTO_00217534 This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] 5916 RARG NR1B3 RARG gene dto:DTO_00217535 Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] 5465 PPARA NR1C1 PPAR PPARA gene dto:DTO_00217536 This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010] 5467 PPARD NR1C2 PPARB PPARD gene dto:DTO_00217537 This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] 5468 PPARG NR1C3 PPARG gene dto:DTO_00217538 This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013] 9572 NR1D1 EAR1 HREV THRAL NR1D1 gene dto:DTO_00217539 This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009] 9975 NR1D2 NR1D2 gene dto:DTO_00217540 The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014] 6095 RORA NR1F1 RZRA RORA gene dto:DTO_00217541 RORB NR1F2 RZRB RORB gene dto:DTO_00217542 The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 6097 RORC NR1F3 RORG RZRG RORC gene dto:DTO_00217543 This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] 9971 NR1H4 BAR FXR HRR1 NR1H4 gene dto:DTO_00217544 The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] 10062 NR1H3 LXRA NR1H3 gene dto:DTO_00217545 The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010] 7376 NR1H2 LXRB NER UNR NR1H2 gene dto:DTO_00217546 This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011] 7421 VDR NR1I1 VDR gene dto:DTO_00217547 This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008] 8856 NR1I2 PXR NR1I2 gene dto:DTO_00217548 This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 9970 NR1I3 CAR NR1I3 gene dto:DTO_00217549 The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012] 3172 HNF4A HNF4 NR2A1 TCF14 HNF4A gene dto:DTO_00217550 3174 HNF4G NR2A2 HNF4G gene dto:DTO_00217551 Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014] 6256 RXRA NR2B1 RXRA gene dto:DTO_00217552 This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] 6257 RXRB NR2B2 RXRB gene dto:DTO_00217553 This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010] 6258 RXRG NR2B3 RXRG gene dto:DTO_00217554 This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] 7181 NR2C1 TR2 NR2C1 gene dto:DTO_00217555 This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] 7182 NR2C2 TAK1 TR4 NR2C2 gene dto:DTO_00217556 7101 NR2E1 TLX NR2E1 gene dto:DTO_00217557 This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 10002 NR2E3 PNR RNR NR2E3 gene dto:DTO_00217558 The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014] 7025 NR2F1 EAR3 ERBAL3 TFCOUP1 NR2F1 gene dto:DTO_00217559 This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] 7026 NR2F2 ARP1 TFCOUP2 NR2F2 gene dto:DTO_00217560 2063 NR2F6 EAR2 ERBAL2 NR2F6 gene dto:DTO_00217561 This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014] 2099 ESR1 ESR NR3A1 ESR1 gene dto:DTO_00217562 This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008] 2100 ESR2 ESTRB NR3A2 ESR2 gene dto:DTO_00217563 The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] 2101 ESRRA ERR1 ESRL1 NR3B1 ESRRA gene dto:DTO_00217564 This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008] 2103 ESRRB ERRB2 ESRL2 NR3B2 ESRRB gene dto:DTO_00217565 This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011] 2104 ESRRG ERR3 ERRG2 KIAA0832 ESRRG gene dto:DTO_00217566 The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] 367 AR DHTR NR3C4 AR gene dto:DTO_00217567 This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] 2908 NR3C1 GRL NR3C1 gene dto:DTO_00217568 This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] 4306 NR3C2 MCR MLR NR3C2 gene dto:DTO_00217569 This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011] 5241 PGR NR3C3 PGR gene dto:DTO_00217570 This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] 3164 NR4A1 GFRP1 HMR NAK1 NR4A1 gene dto:DTO_00217571 This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] 4929 NR4A2 NOT NURR1 TINUR NR4A2 gene dto:DTO_00217572 This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] 8013 NR4A3 CSMF NR4A3 gene dto:DTO_00217573 The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008] 2516 NR5A1 AD4BP FTZF1 SF1 NR5A1 gene dto:DTO_00217574 2494 NR5A2 B1F CPF FTF NR5A2 gene dto:DTO_00217575 This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013] 2649 NR6A1 GCNF NR6A1 gene dto:DTO_00400001 A key aim of the KMC is to classify the development/druggability level of targets. KMC currently categorizes targets into four development/druggability levels (TDLs) defined as the subclasses. target development level Target development level dto:DTO_00400002 Tchem These targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below. In some cases, targets have been manually migrated to Tchem by human curation based on small molecule activities from other sources. Tchem dto:DTO_00400003 Tclin These targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action. Tclin dto:DTO_00400004 Tdark These are targets about which virtually nothing is known. They do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy two or more of the following criteria: (1) A PubMed text-mining score from Jensen Lab < 5 (2) <= 3 Gene RIFs (3) <= 50 Antibodies available according to http://antibodypedia.com Tdark dto:DTO_00400202 These targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: (1)target is above the cutoff criteria for Tdark, (2)target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code, (3)target has confirmed OMIM phenotype(s) (source: http://juniper.health.unm.edu/tcrd/) Tbio dto:DTO_00500646 "Ligand-gated" is used in context to certain ion channel proteins. Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl? to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter. Ligand-gated dto:DTO_00500647 "Voltage-gated" is used in context to certain ion channel proteins. Ion channels that open or close in response to changes in the membrane potential are termed voltage-gated. https://courses.washington.edu/conj/membrane/transport.htm Voltage-gated dto:DTO_00500648 "Mechanically-gated" is used in context to certain ion channel proteins. Mechanically-gated ion channels are the channels that open in response to mechanical movement of adjacent structures. https://courses.washington.edu/conj/membrane/transport.htm Mechanically-gated dto:DTO_00500649 "Temperature-gated" is used in context to certain ion channel proteins. These ion channels open with either an increase in temperature or decrease in temperature. https://courses.washington.edu/conj/membrane/transport.htm Temperature-gated dto:DTO_00500669 The mechanism for the inter-conversion of the open-and-closed states of an ion channel. Gating mechanism dto:DTO_01100001 A 5-hydroxytryptamine receptor 3A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46098] https://pharos.nih.gov/idg/targets/P46098 HTR3A 5HT3R HTR3 P46098 5-hydroxytryptamine receptor 3A dto:DTO_01100002 A 5-hydroxytryptamine receptor 3B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95264] https://pharos.nih.gov/idg/targets/O95264 HTR3B O95264 5-hydroxytryptamine receptor 3B dto:DTO_01100003 A 5-hydroxytryptamine receptor 3C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXA8] https://pharos.nih.gov/idg/targets/Q8WXA8 HTR3C Q8WXA8 5-hydroxytryptamine receptor 3C dto:DTO_01100004 A 5-hydroxytryptamine receptor 3D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q70Z44] https://pharos.nih.gov/idg/targets/Q70Z44 HTR3D Q70Z44 5-hydroxytryptamine receptor 3d dto:DTO_01100005 A 5-hydroxytryptamine receptor 3E that is encoded in the genome of human. [PRO:DNx, UniProtKB:A5X5Y0] https://pharos.nih.gov/idg/targets/A5X5Y0 HTR3E A5X5Y0 5-hydroxytryptamine receptor 3e dto:DTO_01100006 A neuronal acetylcholine receptor subunit alpha-10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZZ6] https://pharos.nih.gov/idg/targets/Q9GZZ6 CHRNA10 NACHRA10 Q9GZZ6 Neuronal acetylcholine receptor subunit alpha-10 dto:DTO_01100007 A neuronal acetylcholine receptor subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15822] https://pharos.nih.gov/idg/targets/Q15822 CHRNA2 Q15822 Neuronal acetylcholine receptor subunit alpha-2 dto:DTO_01100008 A neuronal acetylcholine receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32297] https://pharos.nih.gov/idg/targets/P32297 CHRNA3 NACHRA3 P32297 Neuronal acetylcholine receptor subunit alpha-3 dto:DTO_01100009 A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43681] https://pharos.nih.gov/idg/targets/P43681 CHRNA4 NACRA4 P43681 Neuronal acetylcholine receptor subunit alpha-4 dto:DTO_01100010 A neuronal acetylcholine receptor subunit alpha-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30532] https://pharos.nih.gov/idg/targets/P30532 CHRNA5 NACHRA5 P30532 Neuronal acetylcholine receptor subunit alpha-5 dto:DTO_01100011 A neuronal acetylcholine receptor subunit alpha-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15825] https://pharos.nih.gov/idg/targets/Q15825 CHRNA6 Q15825 Neuronal acetylcholine receptor subunit alpha-6 dto:DTO_01100012 A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36544] https://pharos.nih.gov/idg/targets/P36544 CHRNA7 CHRFAM7A NACHRA7 P36544 Neuronal acetylcholine receptor subunit alpha-7 dto:DTO_01100013 A neuronal acetylcholine receptor subunit alpha-9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGM1] https://pharos.nih.gov/idg/targets/Q9UGM1 CHRNA9 NACHRA9 Q9UGM1 Neuronal acetylcholine receptor subunit alpha-9 dto:DTO_01100014 An acetylcholine receptor subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P02708] https://pharos.nih.gov/idg/targets/P02708 CHRNA1 ACHRA CHNRA P02708 Acetylcholine receptor subunit alpha dto:DTO_01100015 A neuronal acetylcholine receptor subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17787] https://pharos.nih.gov/idg/targets/P17787 CHRNB2 P17787 Neuronal acetylcholine receptor subunit beta-2 dto:DTO_01100016 A neuronal acetylcholine receptor subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05901] https://pharos.nih.gov/idg/targets/Q05901 CHRNB3 Q05901 Neuronal acetylcholine receptor subunit beta-3 dto:DTO_01100017 A neuronal acetylcholine receptor subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30926] https://pharos.nih.gov/idg/targets/P30926 CHRNB4 P30926 Neuronal acetylcholine receptor subunit beta-4 dto:DTO_01100018 An acetylcholine receptor subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11230] https://pharos.nih.gov/idg/targets/P11230 CHRNB1 ACHRB CHRNB P11230 Acetylcholine receptor subunit beta dto:DTO_01100019 An acetylcholine receptor subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07001] https://pharos.nih.gov/idg/targets/Q07001 CHRND ACHRD Q07001 Acetylcholine receptor subunit delta dto:DTO_01100020 An acetylcholine receptor subunit epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04844] https://pharos.nih.gov/idg/targets/Q04844 CHRNE ACHRE Q04844 Acetylcholine receptor subunit epsilon dto:DTO_01100021 An acetylcholine receptor subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07510] https://pharos.nih.gov/idg/targets/P07510 CHRNG ACHRG P07510 Acetylcholine receptor subunit gamma dto:DTO_01100022 An anoctamin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5XXA6] https://pharos.nih.gov/idg/targets/Q5XXA6 ANO1 DOG1 ORAOV2 TAOS2 TMEM16A Q5XXA6 Anoctamin-1 dto:DTO_01100023 An anoctamin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ90] https://pharos.nih.gov/idg/targets/Q9NQ90 ANO2 C12orf3 TMEM16B Q9NQ90 Anoctamin-2 dto:DTO_01100024 An anoctamin-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q4KMQ2] https://pharos.nih.gov/idg/targets/Q4KMQ2 ANO6 TMEM16F Q4KMQ2 Anoctamin-6 dto:DTO_01100025 An acid-sensing ion channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78348] https://pharos.nih.gov/idg/targets/P78348 ASIC1 ACCN2 BNAC2 P78348 Acid-sensing ion channel 1 dto:DTO_01100026 An acid-sensing ion channel 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16515] https://pharos.nih.gov/idg/targets/Q16515 ASIC2 ACCN ACCN1 BNAC1 MDEG Q16515 Acid-sensing ion channel 2 dto:DTO_01100027 An acid-sensing ion channel 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHC3] https://pharos.nih.gov/idg/targets/Q9UHC3 ASIC3 ACCN3 SLNAC1 TNAC1 Q9UHC3 Acid-sensing ion channel 3 dto:DTO_01100028 An acid-sensing ion channel 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96FT7] https://pharos.nih.gov/idg/targets/Q96FT7 ASIC4 ACCN4 Q96FT7 Acid-sensing ion channel 4 dto:DTO_01100029 An acid-sensing ion channel 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY37] https://pharos.nih.gov/idg/targets/Q9NY37 ASIC5 ACCN5 HINAC Q9NY37 Acid-sensing ion channel 5 dto:DTO_01100030 A bestrophin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76090] https://pharos.nih.gov/idg/targets/O76090 BEST1 VMD2 O76090 Bestrophin-1 dto:DTO_01100031 A bestrophin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU1] https://pharos.nih.gov/idg/targets/Q8NFU1 BEST2 VMD2L1 Q8NFU1 Bestrophin-2 dto:DTO_01100032 A bestrophin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N1M1] https://pharos.nih.gov/idg/targets/Q8N1M1 BEST3 VMD2L3 Q8N1M1 Bestrophin-3 dto:DTO_01100033 A bestrophin-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU0] https://pharos.nih.gov/idg/targets/Q8NFU0 BEST4 VMD2L2 Q8NFU0 Bestrophin-4 dto:DTO_01100034 A voltage-dependent calcium channel subunit alpha-2/delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54289] https://pharos.nih.gov/idg/targets/P54289 CACNA2D1 CACNL2A CCHL2A MHS3 P54289 Voltage-dependent calcium channel subunit alpha-2/delta-1 dto:DTO_01100035 A voltage-dependent calcium channel subunit alpha-2/delta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY47] https://pharos.nih.gov/idg/targets/Q9NY47 CACNA2D2 KIAA0558 Q9NY47 Voltage-dependent calcium channel subunit alpha-2/delta-2 dto:DTO_01100036 A voltage-dependent calcium channel subunit alpha-2/delta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZS8] https://pharos.nih.gov/idg/targets/Q8IZS8 CACNA2D3 Q8IZS8 Voltage-dependent calcium channel subunit alpha-2/delta-3 dto:DTO_01100037 A voltage-dependent calcium channel subunit alpha-2/delta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3S7] https://pharos.nih.gov/idg/targets/Q7Z3S7 CACNA2D4 Q7Z3S7 Voltage-dependent calcium channel subunit alpha-2/delta-4 dto:DTO_01100038 A voltage-dependent P/Q-type calcium channel subunit alpha-1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00555] https://pharos.nih.gov/idg/targets/O00555 CACNA1A CACH4 CACN3 CACNL1A4 O00555 Voltage-dependent p/q-type calcium channel subunit alpha-1a dto:DTO_01100039 A voltage-dependent N-type calcium channel subunit alpha-1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q00975] https://pharos.nih.gov/idg/targets/Q00975 CACNA1B CACH5 CACNL1A5 Q00975 Voltage-dependent n-type calcium channel subunit alpha-1b dto:DTO_01100040 A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13936] https://pharos.nih.gov/idg/targets/Q13936 CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 Q13936 Voltage-dependent L-type calcium channel subunit alpha-1C dto:DTO_01100041 A voltage-dependent L-type calcium channel subunit alpha-1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01668] https://pharos.nih.gov/idg/targets/Q01668 CACNA1D CACH3 CACN4 CACNL1A2 CCHL1A2 Q01668 Voltage-dependent l-type calcium channel subunit alpha-1d dto:DTO_01100042 A voltage-dependent R-type calcium channel subunit alpha-1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15878] https://pharos.nih.gov/idg/targets/Q15878 CACNA1E CACH6 CACNL1A6 Q15878 Voltage-dependent r-type calcium channel subunit alpha-1e dto:DTO_01100043 A voltage-dependent L-type calcium channel subunit alpha-1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60840] https://pharos.nih.gov/idg/targets/O60840 CACNA1F CACNAF1 O60840 Voltage-dependent L-type calcium channel subunit alpha-1F dto:DTO_01100044 A voltage-dependent T-type calcium channel subunit alpha-1G that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43497] https://pharos.nih.gov/idg/targets/O43497 CACNA1G KIAA1123 O43497 Voltage-dependent t-type calcium channel subunit alpha-1g dto:DTO_01100045 A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95180] https://pharos.nih.gov/idg/targets/O95180 CACNA1H O95180 Voltage-dependent T-type calcium channel subunit alpha-1H dto:DTO_01100046 A voltage-dependent T-type calcium channel subunit alpha-1I that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P0X4] https://pharos.nih.gov/idg/targets/Q9P0X4 CACNA1I KIAA1120 Q9P0X4 Voltage-dependent t-type calcium channel subunit alpha-1i dto:DTO_01100047 A voltage-dependent L-type calcium channel subunit alpha-1S that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13698] https://pharos.nih.gov/idg/targets/Q13698 CACNA1S CACH1 CACN1 CACNL1A3 Q13698 Voltage-dependent l-type calcium channel subunit alpha-1s dto:DTO_01100048 A voltage-dependent L-type calcium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02641] https://pharos.nih.gov/idg/targets/Q02641 CACNB1 CACNLB1 Q02641 Voltage-dependent L-type calcium channel subunit beta-1 dto:DTO_01100049 A voltage-dependent L-type calcium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08289] https://pharos.nih.gov/idg/targets/Q08289 CACNB2 CACNLB2 MYSB Q08289 Voltage-dependent L-type calcium channel subunit beta-2 dto:DTO_01100050 A voltage-dependent L-type calcium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54284] https://pharos.nih.gov/idg/targets/P54284 CACNB3 CACNLB3 P54284 Voltage-dependent l-type calcium channel subunit beta-3 dto:DTO_01100051 A voltage-dependent L-type calcium channel subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00305] https://pharos.nih.gov/idg/targets/O00305 CACNB4 CACNLB4 O00305 Voltage-dependent l-type calcium channel subunit beta-4 dto:DTO_01100052 A calcium homeostasis modulator protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IU99] https://pharos.nih.gov/idg/targets/Q8IU99 CALHM1 FAM26C Q8IU99 Calcium homeostasis modulator protein 1 dto:DTO_01100053 A calcium homeostasis modulator protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HA72] https://pharos.nih.gov/idg/targets/Q9HA72 CALHM2 FAM26B Q9HA72 Calcium homeostasis modulator protein 2 dto:DTO_01100054 A calcium homeostasis modulator protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86XJ0] https://pharos.nih.gov/idg/targets/Q86XJ0 CALHM3 FAM26A Q86XJ0 Calcium homeostasis modulator protein 3 dto:DTO_01100055 A voltage-dependent calcium channel gamma-1 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06432] https://pharos.nih.gov/idg/targets/Q06432 CACNG1 CACNLG Q06432 Voltage-dependent calcium channel gamma-1 subunit dto:DTO_01100056 A voltage-dependent calcium channel gamma-2 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y698] https://pharos.nih.gov/idg/targets/Q9Y698 CACNG2 Q9Y698 Voltage-dependent calcium channel gamma-2 subunit dto:DTO_01100057 A voltage-dependent calcium channel gamma-3 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60359] https://pharos.nih.gov/idg/targets/O60359 CACNG3 O60359 Voltage-dependent calcium channel gamma-3 subunit dto:DTO_01100058 A voltage-dependent calcium channel gamma-4 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBN1] https://pharos.nih.gov/idg/targets/Q9UBN1 CACNG4 Q9UBN1 Voltage-dependent calcium channel gamma-4 subunit dto:DTO_01100059 A voltage-dependent calcium channel gamma-5 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UF02] https://pharos.nih.gov/idg/targets/Q9UF02 CACNG5 Q9UF02 Voltage-dependent calcium channel gamma-5 subunit dto:DTO_01100060 A voltage-dependent calcium channel gamma-6 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXT2] https://pharos.nih.gov/idg/targets/Q9BXT2 CACNG6 Q9BXT2 Voltage-dependent calcium channel gamma-6 subunit dto:DTO_01100061 A voltage-dependent calcium channel gamma-7 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62955] https://pharos.nih.gov/idg/targets/P62955 CACNG7 P62955 Voltage-dependent calcium channel gamma-7 subunit dto:DTO_01100062 A voltage-dependent calcium channel gamma-8 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXS5] https://pharos.nih.gov/idg/targets/Q8WXS5 CACNG8 CACNG6 Q8WXS5 Voltage-dependent calcium channel gamma-8 subunit dto:DTO_01100063 A voltage-dependent calcium channel gamma-like subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXS4] https://pharos.nih.gov/idg/targets/Q8WXS4 TMEM37 PR Q8WXS4 Voltage-dependent calcium channel gamma-like subunit dto:DTO_01100064 A cystic fibrosis transmembrane conductance regulator (cftr) that is encoded in the genome of human. [PRO:CNA, UniProtKB:P13569] https://pharos.nih.gov/idg/targets/P13569 CFTR ABCC7 P13569 Cystic fibrosis transmembrane conductance regulator dto:DTO_01100065 A calcium-activated chloride channel regulator 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A8K7I4] https://pharos.nih.gov/idg/targets/A8K7I4 CLCA1 CACC1 A8K7I4 Calcium-activated chloride channel regulator 1 dto:DTO_01100066 A calcium-activated chloride channel regulator 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQC9] https://pharos.nih.gov/idg/targets/Q9UQC9 CLCA2 CACC3 Q9UQC9 Calcium-activated chloride channel regulator 2 dto:DTO_01100067 A calcium-activated chloride channel regulator family member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6N3] https://pharos.nih.gov/idg/targets/Q9Y6N3 CLCA3P CLCA3 Q9Y6N3 Calcium-activated chloride channel regulator family member 3 dto:DTO_01100068 A calcium-activated chloride channel regulator 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14CN2] https://pharos.nih.gov/idg/targets/Q14CN2 CLCA4 CaCC2 Q14CN2 Calcium-activated chloride channel regulator 4 dto:DTO_01100069 A chloride channel CLIC-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S66] https://pharos.nih.gov/idg/targets/Q96S66 CLCC1 KIAA0761 MCLC Q96S66 Chloride channel CLIC-like protein 1 dto:DTO_01100070 A chloride channel protein ClC-Ka that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51800] https://pharos.nih.gov/idg/targets/P51800 CLCNKA P51800 Chloride channel protein clc-ka dto:DTO_01100071 A chloride channel protein ClC-Kb that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51801] https://pharos.nih.gov/idg/targets/P51801 CLCNKB P51801 Chloride channel protein clc-kb dto:DTO_01100072 A chloride channel protein, skeletal muscle that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35523] https://pharos.nih.gov/idg/targets/P35523 CLCN1 CLC1 P35523 Chloride channel protein 1 dto:DTO_01100073 A chloride channel protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51788] https://pharos.nih.gov/idg/targets/P51788 CLCN2 P51788 Chloride channel protein 2 dto:DTO_01100074 An H(+)/Cl(-) exchange transporter 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51790] https://pharos.nih.gov/idg/targets/P51790 CLCN3 P51790 H(+)/Cl(-) exchange transporter 3 dto:DTO_01100075 An H(+)/Cl(-) exchange transporter 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51793] https://pharos.nih.gov/idg/targets/P51793 CLCN4 P51793 H(+)/cl(-) exchange transporter 4 dto:DTO_01100076 An H(+)/Cl(-) exchange transporter 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51795] https://pharos.nih.gov/idg/targets/P51795 CLCN5 CLCK2 P51795 H(+)/cl(-) exchange transporter 5 dto:DTO_01100077 A chloride channel protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51797] https://pharos.nih.gov/idg/targets/P51797 CLCN6 KIAA0046 P51797 Chloride transport protein 6 dto:DTO_01100078 An H(+)/Cl(-) exchange transporter 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51798] https://pharos.nih.gov/idg/targets/P51798 CLCN7 P51798 H(+)/Cl(-) exchange transporter 7 dto:DTO_01100079 A chloride intracellular channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00299] https://pharos.nih.gov/idg/targets/O00299 CLIC1 G6 NCC27 O00299 Chloride intracellular channel protein 1 dto:DTO_01100080 A chloride intracellular channel protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15247] https://pharos.nih.gov/idg/targets/O15247 CLIC2 O15247 Chloride intracellular channel protein 2 dto:DTO_01100081 A chloride intracellular channel protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95833] https://pharos.nih.gov/idg/targets/O95833 CLIC3 O95833 Chloride intracellular channel protein 3 dto:DTO_01100082 A chloride intracellular channel protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y696] https://pharos.nih.gov/idg/targets/Q9Y696 CLIC4 Q9Y696 Chloride intracellular channel protein 4 dto:DTO_01100083 A chloride intracellular channel protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZA1] https://pharos.nih.gov/idg/targets/Q9NZA1 CLIC5 Q9NZA1 Chloride intracellular channel protein 5 dto:DTO_01100084 A chloride intracellular channel protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96NY7] https://pharos.nih.gov/idg/targets/Q96NY7 CLIC6 CLIC1L Q96NY7 Chloride intracellular channel protein 6 dto:DTO_01100085 A cGMP-gated cation channel alpha-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P29973] https://pharos.nih.gov/idg/targets/P29973 CNGA1 CNCG CNCG1 P29973 CGMP-gated cation channel alpha-1 dto:DTO_01100086 A cyclic nucleotide-gated olfactory channel that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16280] https://pharos.nih.gov/idg/targets/Q16280 CNGA2 CNCA CNCA1 CNCG2 Q16280 Cyclic nucleotide-gated olfactory channel dto:DTO_01100087 A cyclic nucleotide-gated cation channel alpha-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16281] https://pharos.nih.gov/idg/targets/Q16281 CNGA3 CNCG3 Q16281 Cyclic nucleotide-gated cation channel alpha-3 dto:DTO_01100088 A cyclic nucleotide-gated cation channel alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IV77] https://pharos.nih.gov/idg/targets/Q8IV77 CNGA4 Q8IV77 Cyclic nucleotide-gated cation channel alpha-4 dto:DTO_01100089 A cyclic nucleotide-gated cation channel beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14028] https://pharos.nih.gov/idg/targets/Q14028 CNGB1 CNCG2 CNCG3L CNCG4 RCNC2 Q14028 Cyclic nucleotide-gated cation channel beta-1 dto:DTO_01100090 A cyclic nucleotide-gated cation channel beta-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NQW8] https://pharos.nih.gov/idg/targets/Q9NQW8 CNGB3 Q9NQW8 Cyclic nucleotide-gated cation channel beta-3 dto:DTO_01100091 A calcium release-activated calcium channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D31] https://pharos.nih.gov/idg/targets/Q96D31 ORAI1 CRACM1 TMEM142A Q96D31 Calcium release-activated calcium channel protein 1 dto:DTO_01100092 A calsenilin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2W7] https://pharos.nih.gov/idg/targets/Q9Y2W7 KCNIP3 CSEN DREAM KCHIP3 Q9Y2W7 Calsenilin dto:DTO_01100093 A cation channel sperm-associated protein 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NEC5] https://pharos.nih.gov/idg/targets/Q8NEC5 CATSPER1 Q8NEC5 Cation channel sperm-associated protein 1 dto:DTO_01100094 A cation channel sperm-associated protein 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96P56] https://pharos.nih.gov/idg/targets/Q96P56 CATSPER2 Q96P56 Cation channel sperm-associated protein 2 dto:DTO_01100095 A cation channel sperm-associated protein 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q86XQ3] https://pharos.nih.gov/idg/targets/Q86XQ3 CATSPER3 Q86XQ3 Cation channel sperm-associated protein 3 dto:DTO_01100096 A cation channel sperm-associated protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX7] https://pharos.nih.gov/idg/targets/Q7RTX7 CATSPER4 Q7RTX7 Cation channel sperm-associated protein 4 dto:DTO_01100097 A cytochrome b-245 heavy chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04839] https://pharos.nih.gov/idg/targets/P04839 CYBB NOX2 P04839 Cytochrome b-245 heavy chain dto:DTO_01100098 A protein FAM26D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JW98] https://pharos.nih.gov/idg/targets/Q5JW98 FAM26D C6orf78 Q5JW98 Protein FAM26D dto:DTO_01100099 A protein FAM26E that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N5C1] https://pharos.nih.gov/idg/targets/Q8N5C1 FAM26E C6orf188 Q8N5C1 Protein FAM26E dto:DTO_01100100 A protein FAM26F that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5R3K3] https://pharos.nih.gov/idg/targets/Q5R3K3 441168 FAM26F Protein FAM26F C6orf187 Q5R3K3 Protein FAM26F dto:DTO_01100101 An FXYD domain-containing ion transport regulator 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14802] https://pharos.nih.gov/idg/targets/Q14802 FXYD3 MAT8 PLML Q14802 Fxyd domain-containing ion transport regulator 3 dto:DTO_01100102 An FXYD domain-containing ion transport regulator 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59646] https://pharos.nih.gov/idg/targets/P59646 FXYD4 P59646 FXYD domain-containing ion transport regulator 4 dto:DTO_01100103 An FXYD domain-containing ion transport regulator 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96DB9] https://pharos.nih.gov/idg/targets/Q96DB9 FXYD5 DYSAD IWU1 Q96DB9 FXYD domain-containing ion transport regulator 5 dto:DTO_01100104 An FXYD domain-containing ion transport regulator 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H0Q3] https://pharos.nih.gov/idg/targets/Q9H0Q3 FXYD6 Q9H0Q3 FXYD domain-containing ion transport regulator 6 dto:DTO_01100105 An FXYD domain-containing ion transport regulator 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58549] https://pharos.nih.gov/idg/targets/P58549 FXYD7 P58549 Fxyd domain-containing ion transport regulator 7 dto:DTO_01100106 https://pharos.nih.gov/idg/targets/P58550 FXYD6P3 FXYD8 P58550 Putative fxyd domain-containing ion transport regulator 8 dto:DTO_01100107 A gamma-aminobutyric acid receptor subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14867] https://pharos.nih.gov/idg/targets/P14867 GABRA1 P14867 Gamma-aminobutyric acid receptor subunit alpha-1 dto:DTO_01100108 A gamma-aminobutyric acid receptor subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47869] https://pharos.nih.gov/idg/targets/P47869 GABRA2 P47869 Gamma-aminobutyric acid receptor subunit alpha-2 dto:DTO_01100109 A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34903] https://pharos.nih.gov/idg/targets/P34903 GABRA3 P34903 Gamma-aminobutyric acid receptor subunit alpha-3 dto:DTO_01100110 A gamma-aminobutyric acid receptor subunit alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48169] https://pharos.nih.gov/idg/targets/P48169 GABRA4 P48169 Gamma-aminobutyric acid receptor subunit alpha-4 dto:DTO_01100111 A gamma-aminobutyric acid receptor subunit alpha-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31644] https://pharos.nih.gov/idg/targets/P31644 GABRA5 P31644 Gamma-aminobutyric acid receptor subunit alpha-5 dto:DTO_01100112 A gamma-aminobutyric acid receptor subunit alpha-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16445] https://pharos.nih.gov/idg/targets/Q16445 GABRA6 Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 dto:DTO_01100113 A gamma-aminobutyric acid receptor subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18505] https://pharos.nih.gov/idg/targets/P18505 GABRB1 P18505 Gamma-aminobutyric acid receptor subunit beta-1 dto:DTO_01100114 A gamma-aminobutyric acid receptor subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47870] https://pharos.nih.gov/idg/targets/P47870 GABRB2 P47870 Gamma-aminobutyric acid receptor subunit beta-2 dto:DTO_01100115 A gamma-aminobutyric acid receptor subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28472] https://pharos.nih.gov/idg/targets/P28472 GABRB3 P28472 Gamma-aminobutyric acid receptor subunit beta-3 dto:DTO_01100116 A gamma-aminobutyric acid receptor subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14764] https://pharos.nih.gov/idg/targets/O14764 GABRD O14764 Gamma-aminobutyric acid receptor subunit delta dto:DTO_01100117 A gamma-aminobutyric acid receptor subunit epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78334] https://pharos.nih.gov/idg/targets/P78334 GABRE P78334 Gamma-aminobutyric acid receptor subunit epsilon dto:DTO_01100118 A gamma-aminobutyric acid receptor subunit gamma-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N1C3] https://pharos.nih.gov/idg/targets/Q8N1C3 GABRG1 Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 dto:DTO_01100119 A gamma-aminobutyric acid receptor subunit gamma-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18507] https://pharos.nih.gov/idg/targets/P18507 GABRG2 P18507 Gamma-aminobutyric acid receptor subunit gamma-2 dto:DTO_01100120 A gamma-aminobutyric acid receptor subunit gamma-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99928] https://pharos.nih.gov/idg/targets/Q99928 GABRG3 Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 dto:DTO_01100121 A gamma-aminobutyric acid receptor subunit pi that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00591] https://pharos.nih.gov/idg/targets/O00591 GABRP O00591 Gamma-aminobutyric acid receptor subunit pi dto:DTO_01100122 A gamma-aminobutyric acid receptor subunit rho-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24046] https://pharos.nih.gov/idg/targets/P24046 GABRR1 P24046 Gamma-aminobutyric acid receptor subunit rho-1 dto:DTO_01100123 A gamma-aminobutyric acid receptor subunit rho-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28476] https://pharos.nih.gov/idg/targets/P28476 GABRR2 P28476 Gamma-aminobutyric acid receptor subunit rho-2 dto:DTO_01100124 A gamma-aminobutyric acid receptor subunit rho-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A8MPY1] https://pharos.nih.gov/idg/targets/A8MPY1 GABRR3 A8MPY1 Gamma-aminobutyric acid receptor subunit rho-3 dto:DTO_01100125 A gamma-aminobutyric acid receptor subunit theta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UN88] https://pharos.nih.gov/idg/targets/Q9UN88 GABRQ Q9UN88 Gamma-aminobutyric acid receptor subunit theta dto:DTO_01100126 A glycine receptor subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23415] https://pharos.nih.gov/idg/targets/P23415 GLRA1 P23415 Glycine receptor subunit alpha-1 dto:DTO_01100127 A glycine receptor subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23416] https://pharos.nih.gov/idg/targets/P23416 GLRA2 P23416 Glycine receptor subunit alpha-2 dto:DTO_01100128 A glycine receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75311] https://pharos.nih.gov/idg/targets/O75311 GLRA3 O75311 Glycine receptor subunit alpha-3 dto:DTO_01100129 A glycine receptor subunit alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JXX5] https://pharos.nih.gov/idg/targets/Q5JXX5 GLRA4 Q5JXX5 Glycine receptor subunit alpha-4 dto:DTO_01100130 A glycine receptor subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48167] https://pharos.nih.gov/idg/targets/P48167 GLRB P48167 Glycine receptor subunit beta dto:DTO_01100131 A Golgi pH regulator A that is encoded in the genome of human. [PRO:DNx, UniProtKB:B7ZAQ6] https://pharos.nih.gov/idg/targets/B7ZAQ6 GPR89A GPHRA GPR89 SH120 B7ZAQ6 Golgi ph regulator a dto:DTO_01100132 A Golgi pH regulator B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0CG08] https://pharos.nih.gov/idg/targets/P0CG08 GPR89B GPHRB P0CG08 Golgi ph regulator b dto:DTO_01100133 A glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42261] https://pharos.nih.gov/idg/targets/P42261 GRIA1 GLUH1 GLUR1 P42261 Glutamate receptor 1 dto:DTO_01100134 A glutamate receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42262] https://pharos.nih.gov/idg/targets/P42262 GRIA2 GLUR2 P42262 Glutamate receptor 2 dto:DTO_01100135 A glutamate receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42263] https://pharos.nih.gov/idg/targets/P42263 GRIA3 GLUR3 GLURC P42263 Glutamate receptor 3 dto:DTO_01100136 A glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48058] https://pharos.nih.gov/idg/targets/P48058 GRIA4 GLUR4 P48058 Glutamate receptor 4 dto:DTO_01100137 A glutamate receptor ionotropic, delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULK0] https://pharos.nih.gov/idg/targets/Q9ULK0 GRID1 KIAA1220 Q9ULK0 Glutamate receptor ionotropic, delta-1 dto:DTO_01100138 A glutamate receptor ionotropic, delta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43424] https://pharos.nih.gov/idg/targets/O43424 GRID2 GLURD2 O43424 Glutamate receptor ionotropic, delta-2 dto:DTO_01100139 A glutamate receptor ionotropic, kainate 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39086] https://pharos.nih.gov/idg/targets/P39086 GRIK1 GLUR5 P39086 Glutamate receptor ionotropic, kainate 1 dto:DTO_01100140 A glutamate receptor ionotropic, kainate 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13002] https://pharos.nih.gov/idg/targets/Q13002 GRIK2 GLUR6 Q13002 Glutamate receptor ionotropic, kainate 2 dto:DTO_01100141 A glutamate receptor ionotropic, kainate 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13003] https://pharos.nih.gov/idg/targets/Q13003 GRIK3 GLUR7 Q13003 Glutamate receptor ionotropic, kainate 3 dto:DTO_01100142 A glutamate receptor ionotropic, kainate 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16099] https://pharos.nih.gov/idg/targets/Q16099 GRIK4 GRIK Q16099 Glutamate receptor ionotropic, kainate 4 dto:DTO_01100143 A glutamate receptor ionotropic, kainate 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16478] https://pharos.nih.gov/idg/targets/Q16478 GRIK5 GRIK2 Q16478 Glutamate receptor ionotropic, kainate 5 dto:DTO_01100144 A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O60741] https://pharos.nih.gov/idg/targets/O60741 HCN1 BCNG1 O60741 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 dto:DTO_01100145 A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UL51] https://pharos.nih.gov/idg/targets/Q9UL51 HCN2 BCNG2 Q9UL51 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 dto:DTO_01100146 A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9P1Z3] https://pharos.nih.gov/idg/targets/Q9P1Z3 HCN3 KIAA1535 Q9P1Z3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 dto:DTO_01100147 A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y3Q4] https://pharos.nih.gov/idg/targets/Q9Y3Q4 HCN4 Q9Y3Q4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 dto:DTO_01100148 A voltage-gated hydrogen channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D96] https://pharos.nih.gov/idg/targets/Q96D96 HVCN1 VSOP Q96D96 Voltage-gated hydrogen channel 1 dto:DTO_01100149 An ATP-sensitive inward rectifier potassium channel 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P78508] https://pharos.nih.gov/idg/targets/P78508 KCNJ10 P78508 ATP-sensitive inward rectifier potassium channel 10 dto:DTO_01100150 An ATP-sensitive inward rectifier potassium channel 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14654] https://pharos.nih.gov/idg/targets/Q14654 KCNJ11 Q14654 ATP-sensitive inward rectifier potassium channel 11 dto:DTO_01100151 An ATP-sensitive inward rectifier potassium channel 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14500] https://pharos.nih.gov/idg/targets/Q14500 KCNJ12 IRK2 KCNJN1 Q14500 ATP-sensitive inward rectifier potassium channel 12 dto:DTO_01100152 An inward rectifier potassium channel 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60928] https://pharos.nih.gov/idg/targets/O60928 KCNJ13 O60928 Inward rectifier potassium channel 13 dto:DTO_01100153 An ATP-sensitive inward rectifier potassium channel 14 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UNX9] https://pharos.nih.gov/idg/targets/Q9UNX9 KCNJ14 IRK4 Q9UNX9 Atp-sensitive inward rectifier potassium channel 14 dto:DTO_01100154 An ATP-sensitive inward rectifier potassium channel 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99712] https://pharos.nih.gov/idg/targets/Q99712 KCNJ15 KCNJ14 Q99712 ATP-sensitive inward rectifier potassium channel 15 dto:DTO_01100155 An inward rectifier potassium channel 16 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPI9] https://pharos.nih.gov/idg/targets/Q9NPI9 KCNJ16 Q9NPI9 Inward rectifier potassium channel 16 dto:DTO_01100156 An inward rectifier potassium channel 18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:B7U540] https://pharos.nih.gov/idg/targets/B7U540 KCNJ18 B7U540 Inward rectifier potassium channel 18 dto:DTO_01100157 An ATP-sensitive inward rectifier potassium channel 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48048] https://pharos.nih.gov/idg/targets/P48048 KCNJ1 ROMK1 P48048 ATP-sensitive inward rectifier potassium channel 1 dto:DTO_01100158 An inward rectifier potassium channel 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P63252] https://pharos.nih.gov/idg/targets/P63252 KCNJ2 IRK1 P63252 Inward rectifier potassium channel 2 dto:DTO_01100159 A G protein-activated inward rectifier potassium channel 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48549] https://pharos.nih.gov/idg/targets/P48549 KCNJ3 GIRK1 P48549 G protein-activated inward rectifier potassium channel 1 dto:DTO_01100160 An inward rectifier potassium channel 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48050] https://pharos.nih.gov/idg/targets/P48050 KCNJ4 IRK3 P48050 Inward rectifier potassium channel 4 dto:DTO_01100161 A G protein-activated inward rectifier potassium channel 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48544] https://pharos.nih.gov/idg/targets/P48544 KCNJ5 GIRK4 P48544 G protein-activated inward rectifier potassium channel 4 dto:DTO_01100162 A G protein-activated inward rectifier potassium channel 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48051] https://pharos.nih.gov/idg/targets/P48051 KCNJ6 GIRK2 KATP2 KCNJ7 P48051 G protein-activated inward rectifier potassium channel 2 dto:DTO_01100163 An ATP-sensitive inward rectifier potassium channel 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15842] https://pharos.nih.gov/idg/targets/Q15842 KCNJ8 Q15842 Atp-sensitive inward rectifier potassium channel 8 dto:DTO_01100164 A G protein-activated inward rectifier potassium channel 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92806] https://pharos.nih.gov/idg/targets/Q92806 KCNJ9 GIRK3 Q92806 G protein-activated inward rectifier potassium channel 3 dto:DTO_01100165 An inositol 1,4,5-trisphosphate receptor type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14643] https://pharos.nih.gov/idg/targets/Q14643 ITPR1 INSP3R1 Q14643 Inositol 1,4,5-trisphosphate receptor type 1 dto:DTO_01100166 An inositol 1,4,5-trisphosphate receptor type 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14571] https://pharos.nih.gov/idg/targets/Q14571 ITPR2 Q14571 Inositol 1,4,5-trisphosphate receptor type 2 dto:DTO_01100167 An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573] https://pharos.nih.gov/idg/targets/Q14573 ITPR3 Q14573 Inositol 1,4,5-trisphosphate receptor type 3 dto:DTO_01100168 A voltage-gated potassium channel subunit KCNA10 that is encoded in the genome of human. [] https://pharos.nih.gov/idg/targets/Q16322 KCNA10 Q16322 Potassium voltage-gated channel subfamily a member 10 dto:DTO_01100169 A voltage-gated potassium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14722] https://pharos.nih.gov/idg/targets/Q14722 KCNAB1 KCNA1B Q14722 Voltage-gated potassium channel subunit beta-1 dto:DTO_01100170 A voltage-gated potassium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13303] https://pharos.nih.gov/idg/targets/Q13303 KCNAB2 KCNA2B KCNK2 Q13303 Voltage-gated potassium channel subunit beta-2 dto:DTO_01100171 A voltage-gated potassium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43448] https://pharos.nih.gov/idg/targets/O43448 KCNAB3 KCNA3B O43448 Voltage-gated potassium channel subunit beta-3 dto:DTO_01100172 A Kv channel-interacting protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZI2] https://pharos.nih.gov/idg/targets/Q9NZI2 KCNIP1 KCHIP1 VABP Q9NZI2 Kv channel-interacting protein 1 dto:DTO_01100173 A Kv channel-interacting protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NS61] https://pharos.nih.gov/idg/targets/Q9NS61 KCNIP2 KCHIP2 Q9NS61 Kv channel-interacting protein 2 dto:DTO_01100174 A Kv channel-interacting protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PIL6] https://pharos.nih.gov/idg/targets/Q6PIL6 KCNIP4 CALP KCHIP4 Q6PIL6 Kv channel-interacting protein 4 dto:DTO_01100175 A calcium-activated potassium channel subunit alpha-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q12791] https://pharos.nih.gov/idg/targets/Q12791 KCNMA1 KCNMA SLO Q12791 Calcium-activated potassium channel subunit alpha-1 dto:DTO_01100176 A calcium-activated potassium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16558] https://pharos.nih.gov/idg/targets/Q16558 KCNMB1 Q16558 Calcium-activated potassium channel subunit beta-1 dto:DTO_01100177 A calcium-activated potassium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y691] https://pharos.nih.gov/idg/targets/Q9Y691 KCNMB2 Q9Y691 Calcium-activated potassium channel subunit beta-2 dto:DTO_01100178 A calcium-activated potassium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPA1] https://pharos.nih.gov/idg/targets/Q9NPA1 KCNMB3 KCNMB2 KCNMBL Q9NPA1 Calcium-activated potassium channel subunit beta-3 dto:DTO_01100179 A calcium-activated potassium channel subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W47] https://pharos.nih.gov/idg/targets/Q86W47 KCNMB4 Q86W47 Calcium-activated potassium channel subunit beta-4 dto:DTO_01100180 A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09470] https://pharos.nih.gov/idg/targets/Q09470 KCNA1 Q09470 Potassium voltage-gated channel subfamily A member 1 dto:DTO_01100181 A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of human. [] https://pharos.nih.gov/idg/targets/P16389 KCNA2 P16389 Potassium voltage-gated channel subfamily A member 2 dto:DTO_01100182 A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P22001] https://pharos.nih.gov/idg/targets/P22001 KCNA3 HGK5 P22001 Potassium voltage-gated channel subfamily A member 3 dto:DTO_01100183 A voltage-gated potassium channel alpha subunit KCNA4 that is encoded in the genome of human. [] https://pharos.nih.gov/idg/targets/P22459 KCNA4 KCNA4L P22459 Potassium voltage-gated channel subfamily a member 4 dto:DTO_01100184 A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human. [] https://pharos.nih.gov/idg/targets/P22460 KCNA5 P22460 Potassium voltage-gated channel subfamily a member 5 dto:DTO_01100185 A voltage-gated potassium channel subunit KCNA6 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P17658] https://pharos.nih.gov/idg/targets/P17658 KCNA6 P17658 Potassium voltage-gated channel subfamily A member 6 dto:DTO_01100186 A voltage-gated potassium channel subunit KCNA7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96RP8] https://pharos.nih.gov/idg/targets/Q96RP8 KCNA7 Q96RP8 Potassium voltage-gated channel subfamily A member 7 dto:DTO_01100187 A voltage-gated potassium channel KCNB1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q14721] https://pharos.nih.gov/idg/targets/Q14721 KCNB1 Q14721 Potassium voltage-gated channel subfamily b member 1 dto:DTO_01100188 A voltage-gated potassium channel KCNB2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q92953] https://pharos.nih.gov/idg/targets/Q92953 KCNB2 Q92953 Potassium voltage-gated channel subfamily B member 2 dto:DTO_01100189 A voltage-gated potassium channel KCNC1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P48547] https://pharos.nih.gov/idg/targets/P48547 KCNC1 P48547 Potassium voltage-gated channel subfamily c member 1 dto:DTO_01100190 A voltage-gated potassium channel KCNC2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96PR1] https://pharos.nih.gov/idg/targets/Q96PR1 KCNC2 Q96PR1 Potassium voltage-gated channel subfamily c member 2 dto:DTO_01100191 A voltage-gated potassium channel KCNC3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14003] https://pharos.nih.gov/idg/targets/Q14003 KCNC3 Q14003 Potassium voltage-gated channel subfamily c member 3 dto:DTO_01100192 A voltage-gated potassium channel KCNC4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q03721] https://pharos.nih.gov/idg/targets/Q03721 KCNC4 Q03721 Potassium voltage-gated channel subfamily c member 4 dto:DTO_01100193 A voltage-gated potassium channel KCND1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NSA2] https://pharos.nih.gov/idg/targets/Q9NSA2 KCND1 Q9NSA2 Potassium voltage-gated channel subfamily D member 1 dto:DTO_01100194 A voltage-gated potassium channel KCND2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NZV8] https://pharos.nih.gov/idg/targets/Q9NZV8 KCND2 KIAA1044 Q9NZV8 Potassium voltage-gated channel subfamily d member 2 dto:DTO_01100195 A voltage-gated potassium channel KCND3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UK17] https://pharos.nih.gov/idg/targets/Q9UK17 KCND3 Q9UK17 Potassium voltage-gated channel subfamily D member 3 dto:DTO_01100196 A potassium voltage-gated channel subfamily E member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15382] https://pharos.nih.gov/idg/targets/P15382 KCNE1 P15382 Potassium voltage-gated channel subfamily E member 1 dto:DTO_01100197 A potassium voltage-gated channel subfamily E member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6J6] https://pharos.nih.gov/idg/targets/Q9Y6J6 KCNE2 Q9Y6J6 Potassium voltage-gated channel subfamily e member 2 dto:DTO_01100198 A potassium voltage-gated channel subfamily E member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6H6] https://pharos.nih.gov/idg/targets/Q9Y6H6 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily e member 3 dto:DTO_01100199 A potassium voltage-gated channel subfamily E member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WWG9] https://pharos.nih.gov/idg/targets/Q8WWG9 KCNE4 Q8WWG9 Potassium voltage-gated channel subfamily E member 4 dto:DTO_01100200 A voltage-gated potassium channel KCNF1 that is encoded in the genome of human. [] https://pharos.nih.gov/idg/targets/Q9H3M0 KCNF1 Q9H3M0 Potassium voltage-gated channel subfamily f member 1 dto:DTO_01100201 A voltage-gated potassium channel KCNG1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UIX4] https://pharos.nih.gov/idg/targets/Q9UIX4 KCNG1 Q9UIX4 Potassium voltage-gated channel subfamily G member 1 dto:DTO_01100202 A voltage-gated potassium channel KCNG2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UJ96] https://pharos.nih.gov/idg/targets/Q9UJ96 KCNG2 KCNF2 Q9UJ96 Potassium voltage-gated channel subfamily g member 2 dto:DTO_01100203 A voltage-gated potassium channel KCNG3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TAE7] https://pharos.nih.gov/idg/targets/Q8TAE7 KCNG3 Q8TAE7 Potassium voltage-gated channel subfamily G member 3 dto:DTO_01100204 A voltage-gated potassium channel KCNG4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TDN1] https://pharos.nih.gov/idg/targets/Q8TDN1 KCNG4 KCNG3 Q8TDN1 Potassium voltage-gated channel subfamily G member 4 dto:DTO_01100205 A voltage-gated potassium channel KCNH1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O95259] https://pharos.nih.gov/idg/targets/O95259 KCNH1 EAG EAG1 O95259 Potassium voltage-gated channel subfamily H member 1 dto:DTO_01100206 A voltage-gated potassium channel KCNH2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q12809] https://pharos.nih.gov/idg/targets/Q12809 KCNH2 ERG ERG1 HERG Q12809 Potassium voltage-gated channel subfamily H member 2 dto:DTO_01100207 A voltage-gated potassium channel KCNH3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULD8] https://pharos.nih.gov/idg/targets/Q9ULD8 KCNH3 KIAA1282 Q9ULD8 Potassium voltage-gated channel subfamily H member 3 dto:DTO_01100208 A voltage-gated potassium channel KCNH4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UQ05] https://pharos.nih.gov/idg/targets/Q9UQ05 KCNH4 Q9UQ05 Potassium voltage-gated channel subfamily H member 4 dto:DTO_01100209 A voltage-gated potassium channel KCNH5 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NCM2] https://pharos.nih.gov/idg/targets/Q8NCM2 KCNH5 EAG2 Q8NCM2 Potassium voltage-gated channel subfamily h member 5 dto:DTO_01100210 A voltage-gated potassium channel KCNH6 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9H252] https://pharos.nih.gov/idg/targets/Q9H252 KCNH6 ERG2 Q9H252 Potassium voltage-gated channel subfamily H member 6 dto:DTO_01100211 A voltage-gated potassium channel KCNH7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NS40] https://pharos.nih.gov/idg/targets/Q9NS40 KCNH7 ERG3 Q9NS40 Potassium voltage-gated channel subfamily H member 7 dto:DTO_01100212 A voltage-gated potassium channel KCNH8 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96L42] https://pharos.nih.gov/idg/targets/Q96L42 KCNH8 Q96L42 Potassium voltage-gated channel subfamily H member 8 dto:DTO_01100213 A potassium channel subfamily K member 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00180] https://pharos.nih.gov/idg/targets/O00180 KCNK1 HOHO1 KCNO1 TWIK1 O00180 Potassium channel subfamily K member 1 dto:DTO_01100214 A potassium channel subfamily K member 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95069] https://pharos.nih.gov/idg/targets/O95069 KCNK2 TREK TREK1 O95069 Potassium channel subfamily K member 2 dto:DTO_01100215 A potassium channel subfamily K member 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14649] https://pharos.nih.gov/idg/targets/O14649 KCNK3 TASK TASK1 O14649 Potassium channel subfamily K member 3 dto:DTO_01100216 A potassium channel subfamily K member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYG8] https://pharos.nih.gov/idg/targets/Q9NYG8 KCNK4 TRAAK Q9NYG8 Potassium channel subfamily K member 4 dto:DTO_01100217 A potassium channel subfamily K member 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95279] https://pharos.nih.gov/idg/targets/O95279 KCNK5 TASK2 O95279 Potassium channel subfamily K member 5 dto:DTO_01100218 A potassium channel subfamily K member 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y257] https://pharos.nih.gov/idg/targets/Q9Y257 KCNK6 TOSS TWIK2 Q9Y257 Potassium channel subfamily k member 6 dto:DTO_01100219 A potassium channel subfamily K member 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2U2] https://pharos.nih.gov/idg/targets/Q9Y2U2 KCNK7 Q9Y2U2 Potassium channel subfamily k member 7 dto:DTO_01100220 A potassium channel subfamily K member 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC2] https://pharos.nih.gov/idg/targets/Q9NPC2 KCNK9 TASK3 Q9NPC2 Potassium channel subfamily K member 9 dto:DTO_01100221 A potassium channel subfamily K member 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P57789] https://pharos.nih.gov/idg/targets/P57789 KCNK10 TREK2 P57789 Potassium channel subfamily K member 10 dto:DTO_01100222 A potassium channel subfamily K member 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB15] https://pharos.nih.gov/idg/targets/Q9HB15 KCNK12 Q9HB15 Potassium channel subfamily K member 12 dto:DTO_01100223 A potassium channel subfamily K member 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB14] https://pharos.nih.gov/idg/targets/Q9HB14 KCNK13 Q9HB14 Potassium channel subfamily k member 13 dto:DTO_01100224 A potassium channel subfamily K member 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H427] https://pharos.nih.gov/idg/targets/Q9H427 KCNK15 TASK5 Q9H427 Potassium channel subfamily k member 15 dto:DTO_01100225 A potassium channel subfamily K member 16 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96T55] https://pharos.nih.gov/idg/targets/Q96T55 KCNK16 TALK1 Q96T55 Potassium channel subfamily K member 16 dto:DTO_01100226 A potassium channel subfamily K member 17 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96T54] https://pharos.nih.gov/idg/targets/Q96T54 KCNK17 TALK2 TASK4 Q96T54 Potassium channel subfamily K member 17 dto:DTO_01100227 A potassium channel subfamily K member 18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z418] https://pharos.nih.gov/idg/targets/Q7Z418 KCNK18 TRESK TRIK Q7Z418 Potassium channel subfamily K member 18 dto:DTO_01100228 A small conductance calcium-activated potassium channel protein 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q92952] https://pharos.nih.gov/idg/targets/Q92952 KCNN1 SK Q92952 Small conductance calcium-activated potassium channel protein 1 dto:DTO_01100229 A small conductance calcium-activated potassium channel protein 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9H2S1] https://pharos.nih.gov/idg/targets/Q9H2S1 KCNN2 Q9H2S1 Small conductance calcium-activated potassium channel protein 2 dto:DTO_01100230 A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UGI6] https://pharos.nih.gov/idg/targets/Q9UGI6 KCNN3 K3 Q9UGI6 Small conductance calcium-activated potassium channel protein 3 dto:DTO_01100231 An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of human. [] https://pharos.nih.gov/idg/targets/O15554 KCNN4 IK1 IKCA1 KCA4 SK4 O15554 Intermediate conductance calcium-activated potassium channel protein 4 dto:DTO_01100232 A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P51787] https://pharos.nih.gov/idg/targets/P51787 KCNQ1 KCNA8 KCNA9 KVLQT1 P51787 Potassium voltage-gated channel subfamily kqt member 1 dto:DTO_01100233 A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human. [] https://pharos.nih.gov/idg/targets/O43526 KCNQ2 O43526 Potassium voltage-gated channel subfamily KQT member 2 dto:DTO_01100234 A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of human. [] https://pharos.nih.gov/idg/targets/O43525 KCNQ3 O43525 Potassium voltage-gated channel subfamily KQT member 3 dto:DTO_01100235 A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P56696] https://pharos.nih.gov/idg/targets/P56696 KCNQ4 P56696 Potassium voltage-gated channel subfamily KQT member 4 dto:DTO_01100236 A voltage-gated potassium channel subunit KCNQ5 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NR82] https://pharos.nih.gov/idg/targets/Q9NR82 KCNQ5 Q9NR82 Potassium voltage-gated channel subfamily kqt member 5 dto:DTO_01100237 A voltage-gated potassium channel KCNS1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96KK3] https://pharos.nih.gov/idg/targets/Q96KK3 KCNS1 Q96KK3 Potassium voltage-gated channel subfamily S member 1 dto:DTO_01100238 A voltage-gated potassium channel KCNS2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULS6] https://pharos.nih.gov/idg/targets/Q9ULS6 KCNS2 KIAA1144 Q9ULS6 Potassium voltage-gated channel subfamily s member 2 dto:DTO_01100239 A voltage-gated potassium channel KCNS3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9BQ31] https://pharos.nih.gov/idg/targets/Q9BQ31 KCNS3 Q9BQ31 Potassium voltage-gated channel subfamily s member 3 dto:DTO_01100240 A potassium channel subfamily T member 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5JUK3] https://pharos.nih.gov/idg/targets/Q5JUK3 KCNT1 KIAA1422 Q5JUK3 Potassium channel subfamily t member 1 dto:DTO_01100241 A potassium channel subfamily T member 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6UVM3] https://pharos.nih.gov/idg/targets/Q6UVM3 KCNT2 SLICK Q6UVM3 Potassium channel subfamily t member 2 dto:DTO_01100242 A potassium channel subfamily U member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A8MYU2] https://pharos.nih.gov/idg/targets/A8MYU2 KCNU1 KCNMA3 KCNMC1 SLO3 A8MYU2 Potassium channel subfamily U member 1 dto:DTO_01100243 A voltage-gated potassium channel KCNV1 that is encoded in the genome of human. [] https://pharos.nih.gov/idg/targets/Q6PIU1 KCNV1 Q6PIU1 Potassium voltage-gated channel subfamily v member 1 dto:DTO_01100244 A voltage-gated potassium channel KCNV2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TDN2] https://pharos.nih.gov/idg/targets/Q8TDN2 KCNV2 Q8TDN2 Potassium voltage-gated channel subfamily V member 2 dto:DTO_01100245 A leucine-rich repeat-containing protein 26 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q2I0M4] https://pharos.nih.gov/idg/targets/Q2I0M4 LRRC26 CAPC Q2I0M4 Leucine-rich repeat-containing protein 26 dto:DTO_01100246 A leucine-rich repeat-containing protein 38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VT99] https://pharos.nih.gov/idg/targets/Q5VT99 LRRC38 Q5VT99 Leucine-rich repeat-containing protein 38 dto:DTO_01100247 A leucine-rich repeat-containing protein 52 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N7C0] https://pharos.nih.gov/idg/targets/Q8N7C0 LRRC52 Q8N7C0 Leucine-rich repeat-containing protein 52 dto:DTO_01100248 A leucine-rich repeat-containing protein 55 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZSA7] https://pharos.nih.gov/idg/targets/Q6ZSA7 LRRC55 Q6ZSA7 Leucine-rich repeat-containing protein 55 dto:DTO_01100249 A mucolipin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZU1] https://pharos.nih.gov/idg/targets/Q9GZU1 MCOLN1 ML4 Q9GZU1 Mucolipin-1 dto:DTO_01100250 A mucolipin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZK6] https://pharos.nih.gov/idg/targets/Q8IZK6 MCOLN2 Q8IZK6 Mucolipin-2 dto:DTO_01100251 A mucolipin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDD5] https://pharos.nih.gov/idg/targets/Q8TDD5 MCOLN3 Q8TDD5 Mucolipin-3 dto:DTO_01100252 A calcium uniporter protein, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NE86] https://pharos.nih.gov/idg/targets/Q8NE86 MCU C10orf42 CCDC109A Q8NE86 Calcium uniporter protein, mitochondrial dto:DTO_01100253 A membrane protein MLC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15049] https://pharos.nih.gov/idg/targets/Q15049 MLC1 KIAA0027 WKL1 Q15049 Membrane protein MLC1 dto:DTO_01100254 A sodium leak channel non-selective protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8IZF0] https://pharos.nih.gov/idg/targets/Q8IZF0 NALCN VGCNL1 Q8IZF0 Sodium leak channel non-selective protein dto:DTO_01100255 A glutamate receptor ionotropic, NMDA 3A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCU5] https://pharos.nih.gov/idg/targets/Q8TCU5 GRIN3A KIAA1973 Q8TCU5 Glutamate receptor ionotropic, NMDA 3A dto:DTO_01100256 A glutamate receptor ionotropic, NMDA 3B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60391] https://pharos.nih.gov/idg/targets/O60391 GRIN3B O60391 Glutamate receptor ionotropic, NMDA 3B dto:DTO_01100257 A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12879] https://pharos.nih.gov/idg/targets/Q12879 GRIN2A NMDAR2A Q12879 Glutamate receptor ionotropic, NMDA 2A dto:DTO_01100258 A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13224] https://pharos.nih.gov/idg/targets/Q13224 GRIN2B NMDAR2B Q13224 Glutamate receptor ionotropic, nmda 2b dto:DTO_01100259 A glutamate receptor ionotropic, NMDA 2C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14957] https://pharos.nih.gov/idg/targets/Q14957 GRIN2C NMDAR2C Q14957 Glutamate receptor ionotropic, nmda 2c dto:DTO_01100260 A glutamate receptor ionotropic, NMDA 2D that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15399] https://pharos.nih.gov/idg/targets/O15399 GRIN2D GluN2D NMDAR2D O15399 Glutamate receptor ionotropic, nmda 2d dto:DTO_01100261 A glutamate [NMDA] receptor subunit zeta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05586] https://pharos.nih.gov/idg/targets/Q05586 GRIN1 NMDAR1 Q05586 Glutamate receptor ionotropic, nmda 1 dto:DTO_01100262 An NADPH oxidase 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5S8] https://pharos.nih.gov/idg/targets/Q9Y5S8 NOX1 MOX1 NOH1 Q9Y5S8 Nadph oxidase 1 dto:DTO_01100263 An NADPH oxidase 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96PH1] https://pharos.nih.gov/idg/targets/Q96PH1 NOX5 Q96PH1 Nadph oxidase 5 dto:DTO_01100264 A P2X purinoceptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51575] https://pharos.nih.gov/idg/targets/P51575 P2RX1 P2X1 P51575 P2X purinoceptor 1 dto:DTO_01100265 A P2X purinoceptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBL9] https://pharos.nih.gov/idg/targets/Q9UBL9 P2RX2 P2X2 Q9UBL9 P2x purinoceptor 2 dto:DTO_01100266 A P2X purinoceptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56373] https://pharos.nih.gov/idg/targets/P56373 P2RX3 P56373 P2x purinoceptor 3 dto:DTO_01100267 A P2X purinoceptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99571] https://pharos.nih.gov/idg/targets/Q99571 P2RX4 Q99571 P2X purinoceptor 4 dto:DTO_01100268 A P2X purinoceptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q93086] https://pharos.nih.gov/idg/targets/Q93086 P2RX5 P2X5 Q93086 P2X purinoceptor 5 dto:DTO_01100269 A P2X purinoceptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15547] https://pharos.nih.gov/idg/targets/O15547 P2RX6 P2RXL1 P2X6 O15547 P2X purinoceptor 6 dto:DTO_01100270 A P2X purinoceptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99572] https://pharos.nih.gov/idg/targets/Q99572 P2RX7 Q99572 P2X purinoceptor 7 dto:DTO_01100271 A pannexin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD7] https://pharos.nih.gov/idg/targets/Q96RD7 PANX1 MRS1 Q96RD7 Pannexin-1 dto:DTO_01100272 A pannexin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD6] https://pharos.nih.gov/idg/targets/Q96RD6 PANX2 Q96RD6 Pannexin-2 dto:DTO_01100273 A pannexin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QZ0] https://pharos.nih.gov/idg/targets/Q96QZ0 PANX3 Q96QZ0 Pannexin-3 dto:DTO_01100274 A piezo-type mechanosensitive ion channel component 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92508] https://pharos.nih.gov/idg/targets/Q92508 PIEZO1 FAM38A KIAA0233 Q92508 Piezo-type mechanosensitive ion channel component 1 dto:DTO_01100275 A piezo-type mechanosensitive ion channel component 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H5I5] https://pharos.nih.gov/idg/targets/Q9H5I5 PIEZO2 C18orf30 C18orf58 FAM38B Q9H5I5 Piezo-type mechanosensitive ion channel component 2 dto:DTO_01100276 A polycystic kidney disease protein 1-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z442] https://pharos.nih.gov/idg/targets/Q7Z442 PKD1L2 KIAA1879 PC1L2 Q7Z442 Polycystic kidney disease protein 1-like 2 dto:DTO_01100277 A polycystic kidney disease protein 1-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z443] https://pharos.nih.gov/idg/targets/Q7Z443 PKD1L3 Q7Z443 Polycystic kidney disease protein 1-like 3 dto:DTO_01100278 A polycystic kidney disease 2-like 1 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0L9] https://pharos.nih.gov/idg/targets/Q9P0L9 PKD2L1 PKD2L PKDL TRPP3 Q9P0L9 Polycystic kidney disease 2-like 1 protein dto:DTO_01100279 A polycystic kidney disease 2-like 2 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZM6] https://pharos.nih.gov/idg/targets/Q9NZM6 PKD2L2 Q9NZM6 Polycystic kidney disease 2-like 2 protein dto:DTO_01100280 A polycystin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13563] https://pharos.nih.gov/idg/targets/Q13563 PKD2 Q13563 Polycystin-2 dto:DTO_01100281 A polycystic kidney disease and receptor for egg jelly-related protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NTG1] https://pharos.nih.gov/idg/targets/Q9NTG1 PKDREJ Q9NTG1 Polycystic kidney disease and receptor for egg jelly-related protein dto:DTO_01100282 A plasmolipin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y342] https://pharos.nih.gov/idg/targets/Q9Y342 PLLP PMLP TM4SF11 Q9Y342 Plasmolipin dto:DTO_01100283 A phospholemman that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00168] https://pharos.nih.gov/idg/targets/O00168 FXYD1 PLM O00168 Phospholemman dto:DTO_01100284 A ryanodine receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21817] https://pharos.nih.gov/idg/targets/P21817 RYR1 RYDR P21817 Ryanodine receptor 1 dto:DTO_01100285 A ryanodine receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92736] https://pharos.nih.gov/idg/targets/Q92736 RYR2 Q92736 Ryanodine receptor 2 dto:DTO_01100286 A ryanodine receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15413] https://pharos.nih.gov/idg/targets/Q15413 RYR3 HBRR Q15413 Ryanodine receptor 3 dto:DTO_01100287 A sulfate anion transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2B4] https://pharos.nih.gov/idg/targets/Q9H2B4 SLC26A1 SAT1 Q9H2B4 Sulfate anion transporter 1 dto:DTO_01100288 A solute carrier family 26 member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXS9] https://pharos.nih.gov/idg/targets/Q9BXS9 SLC26A6 Q9BXS9 Solute carrier family 26 member 6 dto:DTO_01100289 A sodium channel protein type 1 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35498] https://pharos.nih.gov/idg/targets/P35498 SCN1A NAC1 SCN1 P35498 Sodium channel protein type 1 subunit alpha dto:DTO_01100290 A sodium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07699] https://pharos.nih.gov/idg/targets/Q07699 SCN1B Q07699 Sodium channel subunit beta-1 dto:DTO_01100291 A sodium channel protein type 2 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99250] https://pharos.nih.gov/idg/targets/Q99250 SCN2A NAC2 SCN2A1 SCN2A2 Q99250 Sodium channel protein type 2 subunit alpha dto:DTO_01100292 A sodium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60939] https://pharos.nih.gov/idg/targets/O60939 SCN2B O60939 Sodium channel subunit beta-2 dto:DTO_01100293 A sodium channel protein type 3 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NY46] https://pharos.nih.gov/idg/targets/Q9NY46 SCN3A KIAA1356 NAC3 Q9NY46 Sodium channel protein type 3 subunit alpha dto:DTO_01100294 A sodium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY72] https://pharos.nih.gov/idg/targets/Q9NY72 SCN3B KIAA1158 Q9NY72 Sodium channel subunit beta-3 dto:DTO_01100295 A sodium channel type 4 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35499] https://pharos.nih.gov/idg/targets/P35499 SCN4A P35499 Sodium channel protein type 4 subunit alpha dto:DTO_01100296 A sodium channel subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWT1] https://pharos.nih.gov/idg/targets/Q8IWT1 SCN4B Q8IWT1 Sodium channel subunit beta-4 dto:DTO_01100297 A sodium channel protein type 5 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14524] https://pharos.nih.gov/idg/targets/Q14524 SCN5A Q14524 Sodium channel protein type 5 subunit alpha dto:DTO_01100298 A sodium channel protein type 7 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01118] https://pharos.nih.gov/idg/targets/Q01118 SCN7A SCN6A Q01118 Sodium channel protein type 7 subunit alpha dto:DTO_01100299 A sodium channel protein type 8 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UQD0] https://pharos.nih.gov/idg/targets/Q9UQD0 SCN8A MED Q9UQD0 Sodium channel protein type 8 subunit alpha dto:DTO_01100300 A sodium channel protein type 9 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15858] https://pharos.nih.gov/idg/targets/Q15858 SCN9A NENA Q15858 Sodium channel protein type 9 subunit alpha dto:DTO_01100301 A sodium channel protein type 10 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y9] https://pharos.nih.gov/idg/targets/Q9Y5Y9 SCN10A Q9Y5Y9 Sodium channel protein type 10 subunit alpha dto:DTO_01100302 A sodium channel protein type 11 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UI33] https://pharos.nih.gov/idg/targets/Q9UI33 SCN11A SCN12A SNS2 Q9UI33 Sodium channel protein type 11 subunit alpha dto:DTO_01100303 An amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37088] https://pharos.nih.gov/idg/targets/P37088 SCNN1A SCNN1 P37088 Amiloride-sensitive sodium channel subunit alpha dto:DTO_01100304 An amiloride-sensitive sodium channel subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51168] https://pharos.nih.gov/idg/targets/P51168 SCNN1B P51168 Amiloride-sensitive sodium channel subunit beta dto:DTO_01100305 An amiloride-sensitive sodium channel subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51172] https://pharos.nih.gov/idg/targets/P51172 SCNN1D DNACH P51172 Amiloride-sensitive sodium channel subunit delta dto:DTO_01100306 An amiloride-sensitive sodium channel subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51170] https://pharos.nih.gov/idg/targets/P51170 SCNN1G P51170 Amiloride-sensitive sodium channel subunit gamma dto:DTO_01100307 A trimeric intracellular cation channel type A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H6F2] https://pharos.nih.gov/idg/targets/Q9H6F2 TMEM38A Q9H6F2 Trimeric intracellular cation channel type a dto:DTO_01100308 A trimeric intracellular cation channel type B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NVV0] https://pharos.nih.gov/idg/targets/Q9NVV0 TMEM38B C9orf87 Q9NVV0 Trimeric intracellular cation channel type B dto:DTO_01100309 A transmembrane channel-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDI8] https://pharos.nih.gov/idg/targets/Q8TDI8 TMC1 Q8TDI8 Transmembrane channel-like protein 1 dto:DTO_01100310 A transmembrane channel-like protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDI7] https://pharos.nih.gov/idg/targets/Q8TDI7 TMC2 C20orf145 Q8TDI7 Transmembrane channel-like protein 2 dto:DTO_01100311 A transmembrane channel-like protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5M5] https://pharos.nih.gov/idg/targets/Q7Z5M5 TMC3 Q7Z5M5 Transmembrane channel-like protein 3 dto:DTO_01100312 A transmembrane channel-like protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z404] https://pharos.nih.gov/idg/targets/Q7Z404 TMC4 Q7Z404 Transmembrane channel-like protein 4 dto:DTO_01100313 A transmembrane channel-like protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6UXY8] https://pharos.nih.gov/idg/targets/Q6UXY8 TMC5 Q6UXY8 Transmembrane channel-like protein 5 dto:DTO_01100314 A transmembrane channel-like protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z403] https://pharos.nih.gov/idg/targets/Q7Z403 TMC6 EVER1 EVIN1 Q7Z403 Transmembrane channel-like protein 6 dto:DTO_01100315 A transmembrane channel-like protein 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z402] https://pharos.nih.gov/idg/targets/Q7Z402 TMC7 Q7Z402 Transmembrane channel-like protein 7 dto:DTO_01100316 A transmembrane channel-like protein 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IU68] https://pharos.nih.gov/idg/targets/Q8IU68 TMC8 EVER2 EVIN2 Q8IU68 Transmembrane channel-like protein 8 dto:DTO_01100317 A two pore calcium channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULQ1] https://pharos.nih.gov/idg/targets/Q9ULQ1 TPCN1 KIAA1169 TPC1 Q9ULQ1 Two pore calcium channel protein 1 dto:DTO_01100318 A two pore calcium channel protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NHX9] https://pharos.nih.gov/idg/targets/Q8NHX9 TPCN2 TPC2 Q8NHX9 Two pore calcium channel protein 2 dto:DTO_01100319 A transient receptor potential cation channel TRPA1 that is encoded in the genome of human. [PRO:HJD, UniProtKB:O75762] https://pharos.nih.gov/idg/targets/O75762 TRPA1 ANKTM1 O75762 Transient receptor potential cation channel subfamily a member 1 dto:DTO_01100320 A short transient receptor potential channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48995] https://pharos.nih.gov/idg/targets/P48995 TRPC1 TRP1 P48995 Short transient receptor potential channel 1 dto:DTO_01100321 A transient receptor potential cation channel TRPC3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13507] https://pharos.nih.gov/idg/targets/Q13507 TRPC3 TRP3 Q13507 Short transient receptor potential channel 3 dto:DTO_01100322 A transient receptor potential cation channel TRPC4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UBN4] https://pharos.nih.gov/idg/targets/Q9UBN4 TRPC4 Q9UBN4 Short transient receptor potential channel 4 dto:DTO_01100323 A short transient receptor potential channel 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UL62] https://pharos.nih.gov/idg/targets/Q9UL62 TRPC5 TRP5 Q9UL62 Short transient receptor potential channel 5 dto:DTO_01100324 A short transient receptor potential channel 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y210] https://pharos.nih.gov/idg/targets/Q9Y210 TRPC6 TRP6 Q9Y210 Short transient receptor potential channel 6 dto:DTO_01100325 A transient receptor potential cation channel TRPC7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HCX4] https://pharos.nih.gov/idg/targets/Q9HCX4 TRPC7 TRP7 Q9HCX4 Short transient receptor potential channel 7 dto:DTO_01100326 A transient receptor potential cation channel subfamily M member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z4N2] https://pharos.nih.gov/idg/targets/Q7Z4N2 TRPM1 LTRPC1 MLSN MLSN1 Q7Z4N2 Transient receptor potential cation channel subfamily m member 1 dto:DTO_01100327 A transient receptor potential cation channel subfamily M member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94759] https://pharos.nih.gov/idg/targets/O94759 TRPM2 EREG1 KNP3 LTRPC2 TRPC7 O94759 Transient receptor potential cation channel subfamily m member 2 dto:DTO_01100328 A transient receptor potential cation channel subfamily M member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCF6] https://pharos.nih.gov/idg/targets/Q9HCF6 TRPM3 KIAA1616 LTRPC3 Q9HCF6 Transient receptor potential cation channel subfamily M member 3 dto:DTO_01100329 A transient receptor potential cation channel subfamily M member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD43] https://pharos.nih.gov/idg/targets/Q8TD43 TRPM4 LTRPC4 Q8TD43 Transient receptor potential cation channel subfamily M member 4 dto:DTO_01100330 A transient receptor potential cation channel subfamily M member 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZQ8] https://pharos.nih.gov/idg/targets/Q9NZQ8 TRPM5 LTRPC5 MTR1 Q9NZQ8 Transient receptor potential cation channel subfamily M member 5 dto:DTO_01100331 A transient receptor potential cation channel subfamily M member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QT4] https://pharos.nih.gov/idg/targets/Q96QT4 TRPM7 CHAK1 LTRPC7 Q96QT4 Transient receptor potential cation channel subfamily M member 7 dto:DTO_01100332 A transient receptor potential cation channel TRPM8 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q7Z2W7] https://pharos.nih.gov/idg/targets/Q7Z2W7 TRPM8 LTRPC6 TRPP8 Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 dto:DTO_01100333 A transient receptor potential cation channel TRPV1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NER1] https://pharos.nih.gov/idg/targets/Q8NER1 TRPV1 VR1 Q8NER1 Transient receptor potential cation channel subfamily V member 1 dto:DTO_01100334 A transient receptor potential cation channel TRPV2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y5S1] https://pharos.nih.gov/idg/targets/Q9Y5S1 TRPV2 VRL Q9Y5S1 Transient receptor potential cation channel subfamily v member 2 dto:DTO_01100335 A transient receptor potential cation channel TRPV3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NET8] https://pharos.nih.gov/idg/targets/Q8NET8 TRPV3 Q8NET8 Transient receptor potential cation channel subfamily V member 3 dto:DTO_01100336 A transient receptor potential cation channel TRPV4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HBA0] https://pharos.nih.gov/idg/targets/Q9HBA0 TRPV4 VRL2 VROAC Q9HBA0 Transient receptor potential cation channel subfamily V member 4 dto:DTO_01100337 A transient receptor potential cation channel subfamily V member 5 that is encoded in the genome of human. [PRO:HJD, UniProtKB:Q9NQA5] https://pharos.nih.gov/idg/targets/Q9NQA5 TRPV5 ECAC1 Q9NQA5 Transient receptor potential cation channel subfamily V member 5 dto:DTO_01100338 A transient receptor potential cation channel subfamily V member 6 that is encoded in the genome of human. [PRO:HJD, UniProtKB:Q9H1D0] https://pharos.nih.gov/idg/targets/Q9H1D0 TRPV6 ECAC2 Q9H1D0 Transient receptor potential cation channel subfamily V member 6 dto:DTO_01100339 A protein tweety homolog 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H313] https://pharos.nih.gov/idg/targets/Q9H313 TTYH1 Q9H313 Protein tweety homolog 1 dto:DTO_01100340 A protein tweety homolog 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BSA4] https://pharos.nih.gov/idg/targets/Q9BSA4 TTYH2 C17orf29 Q9BSA4 Protein tweety homolog 2 dto:DTO_01100341 A protein tweety homolog 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C0H2] https://pharos.nih.gov/idg/targets/Q9C0H2 TTYH3 KIAA1691 Q9C0H2 Protein tweety homolog 3 dto:DTO_01100342 A zinc-activated ligand-gated ion channel that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q401N2] https://pharos.nih.gov/idg/targets/Q401N2 ZACN L2 LGICZ LGICZ1 ZAC Q401N2 Zinc-activated ligand-gated ion channel dto:DTO_01100343 https://pharos.nih.gov/idg/targets/Q8TDX9 PKD1L1 Q8TDX9 Polycystic kidney disease protein 1-like 1 dto:DTO_01200001 The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 3359 HTR3A 5HT3R HTR3 HTR3A gene dto:DTO_01200002 The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011] 9177 HTR3B HTR3B gene dto:DTO_01200003 The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008] 170572 HTR3C HTR3C gene dto:DTO_01200004 The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009] 200909 HTR3D HTR3D gene dto:DTO_01200005 This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012] 285242 HTR3E HTR3E gene dto:DTO_01200006 57053 CHRNA10 NACHRA10 CHRNA10 gene dto:DTO_01200007 Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009] 1135 CHRNA2 CHRNA2 gene dto:DTO_01200008 This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009] 1136 CHRNA3 NACHRA3 CHRNA3 gene dto:DTO_01200009 This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] 1137 CHRNA4 NACRA4 CHRNA4 gene dto:DTO_01200010 The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010] 1138 CHRNA5 NACHRA5 CHRNA5 gene dto:DTO_01200011 This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010] 8973 CHRNA6 CHRNA6 gene dto:DTO_01200012 The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008] 1139 89832 CHRNA7 NACHRA7 CHRNA7 gene dto:DTO_01200013 This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012] 55584 CHRNA9 NACHRA9 CHRNA9 gene dto:DTO_01200014 The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012] 1134 CHRNA1 ACHRA CHNRA CHRNA1 gene dto:DTO_01200015 Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008] 1141 CHRNB2 CHRNB2 gene dto:DTO_01200016 The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010] 1142 CHRNB3 CHRNB3 gene dto:DTO_01200017 1143 CHRNB4 CHRNB4 gene dto:DTO_01200018 The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008] 1140 CHRNB1 ACHRB CHRNB CHRNB1 gene dto:DTO_01200019 The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Feb 2012] 1144 CHRND ACHRD CHRND gene dto:DTO_01200020 Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009] 1145 CHRNE ACHRE CHRNE gene dto:DTO_01200021 The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009] 1146 CHRNG ACHRG CHRNG gene dto:DTO_01200022 55107 ANO1 DOG1 ORAOV2 TAOS2 TMEM16A ANO1 gene dto:DTO_01200023 ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011] 57101 ANO2 C12orf3 TMEM16B ANO2 gene dto:DTO_01200024 This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] 196527 ANO6 TMEM16F ANO6 gene dto:DTO_01200025 This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] 41 ASIC1 ACCN2 BNAC2 ASIC1 gene dto:DTO_01200026 This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012] 40 ASIC2 ACCN ACCN1 BNAC1 MDEG ASIC2 gene dto:DTO_01200027 This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] 9311 ASIC3 ACCN3 SLNAC1 TNAC1 ASIC3 gene dto:DTO_01200028 This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012] 55515 ASIC4 ACCN4 ASIC4 gene dto:DTO_01200029 This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008] 51802 ASIC5 ACCN5 HINAC ASIC5 gene dto:DTO_01200030 This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008] 7439 BEST1 VMD2 BEST1 gene dto:DTO_01200031 This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008] 54831 BEST2 VMD2L1 BEST2 gene dto:DTO_01200032 BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008] 144453 BEST3 VMD2L3 BEST3 gene dto:DTO_01200033 This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 4 gene is predominantly expressed in the colon. [provided by RefSeq, Jul 2008] 266675 BEST4 VMD2L2 BEST4 gene dto:DTO_01200034 The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014] 781 CACNA2D1 CACNL2A CCHL2A MHS3 CACNA2D1 gene dto:DTO_01200035 Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014] 9254 CACNA2D2 KIAA0558 CACNA2D2 gene dto:DTO_01200036 This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] 55799 CACNA2D3 CACNA2D3 gene dto:DTO_01200037 This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] 93589 CACNA2D4 CACNA2D4 gene dto:DTO_01200038 Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Mar 2010] 773 CACNA1A CACH4 CACN3 CACNL1A4 CACNA1A gene dto:DTO_01200039 The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] 774 CACNA1B CACH5 CACNL1A5 CACNA1B gene dto:DTO_01200040 This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012] 775 CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 CACNA1C gene dto:DTO_01200041 Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] 776 CACNA1D CACH3 CACN4 CACNL1A2 CCHL1A2 CACNA1D gene dto:DTO_01200042 Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] 777 CACNA1E CACH6 CACNL1A6 CACNA1E gene dto:DTO_01200043 This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2013] 778 CACNA1F CACNAF1 CACNA1F gene dto:DTO_01200044 Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011] 8913 CACNA1G KIAA1123 CACNA1G gene dto:DTO_01200045 This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008] 8912 CACNA1H CACNA1H gene dto:DTO_01200046 This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] 8911 CACNA1I KIAA1120 CACNA1I gene dto:DTO_01200047 This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008] 779 CACNA1S CACH1 CACN1 CACNL1A3 CACNA1S gene dto:DTO_01200048 The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008] 782 CACNB1 CACNLB1 CACNB1 gene dto:DTO_01200049 This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013] 783 CACNB2 CACNLB2 MYSB CACNB2 gene dto:DTO_01200050 This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011] 784 CACNB3 CACNLB3 CACNB3 gene dto:DTO_01200051 This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] 785 CACNB4 CACNLB4 CACNB4 gene dto:DTO_01200052 This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010] 255022 CALHM1 FAM26C CALHM1 gene dto:DTO_01200053 51063 CALHM2 FAM26B CALHM2 gene dto:DTO_01200054 119395 CALHM3 FAM26A CALHM3 gene dto:DTO_01200055 Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010] 786 CACNG1 CACNLG CACNG1 gene dto:DTO_01200056 The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010] 10369 CACNG2 CACNG2 gene dto:DTO_01200057 The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010] 10368 CACNG3 CACNG3 gene dto:DTO_01200058 The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010] 27092 CACNG4 CACNG4 gene dto:DTO_01200059 The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010] 27091 CACNG5 CACNG5 gene dto:DTO_01200060 Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma. [provided by RefSeq, Dec 2010] 59285 CACNG6 CACNG6 gene dto:DTO_01200061 The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010] 59284 CACNG7 CACNG7 gene dto:DTO_01200062 The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010] 59283 CACNG8 CACNG6 CACNG8 gene dto:DTO_01200063 140738 TMEM37 PR TMEM37 gene dto:DTO_01200064 This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008] 1080 CFTR ABCC7 CFTR gene dto:DTO_01200065 This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008] 1179 CLCA1 CACC1 CLCA1 gene dto:DTO_01200066 The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008] 9635 CLCA2 CACC3 CLCA2 gene dto:DTO_01200067 This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this gene is unlikely to be protein-coding. [provided by RefSeq, Jan 2009] 9629 CLCA3P CLCA3 CLCA3P gene dto:DTO_01200068 The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008] 22802 CLCA4 CaCC2 CLCA4 gene dto:DTO_01200069 23155 CLCC1 KIAA0761 MCLC CLCC1 gene dto:DTO_01200070 This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 1187 CLCNKA CLCNKA gene dto:DTO_01200071 The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] 1188 CLCNKB CLCNKB gene dto:DTO_01200072 The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] 1180 CLCN1 CLC1 CLCN1 gene dto:DTO_01200073 This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] 1181 CLCN2 CLCN2 gene dto:DTO_01200074 This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] 1182 CLCN3 CLCN3 gene dto:DTO_01200075 The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012] 1183 CLCN4 CLCN4 gene dto:DTO_01200076 This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013] 1184 CLCN5 CLCK2 CLCN5 gene dto:DTO_01200077 This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012] 1185 CLCN6 KIAA0046 CLCN6 gene dto:DTO_01200078 The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008] 1186 CLCN7 CLCN7 gene dto:DTO_01200079 Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008] 1192 CLIC1 G6 NCC27 CLIC1 gene dto:DTO_01200080 This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein may play a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of X-linked mental retardation-32. [provided by RefSeq, Aug 2013] 1193 CLIC2 CLIC2 gene dto:DTO_01200081 Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008] 9022 CLIC3 CLIC3 gene dto:DTO_01200082 Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008] 25932 CLIC4 CLIC4 gene dto:DTO_01200083 This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] 53405 CLIC5 CLIC5 gene dto:DTO_01200084 This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008] 54102 CLIC6 CLIC1L CLIC6 gene dto:DTO_01200085 The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] 1259 CNGA1 CNCG CNCG1 CNGA1 gene dto:DTO_01200086 The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010] 1260 CNGA2 CNCA CNCA1 CNCG2 CNGA2 gene dto:DTO_01200087 This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] 1261 CNGA3 CNCG3 CNGA3 gene dto:DTO_01200088 CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008] 1262 CNGA4 CNGA4 gene dto:DTO_01200089 In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013] 1258 CNGB1 CNCG2 CNCG3L CNCG4 RCNC2 CNGB1 gene dto:DTO_01200090 This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010] 54714 CNGB3 CNGB3 gene dto:DTO_01200091 The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] 84876 ORAI1 CRACM1 TMEM142A ORAI1 gene dto:DTO_01200092 KCNIP3 KCNIP3 gene dto:DTO_01200093 Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008] 117144 CATSPER1 CATSPER1 gene dto:DTO_01200094 Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014] 117155 CATSPER2 CATSPER2 gene dto:DTO_01200095 347732 CATSPER3 CATSPER3 gene dto:DTO_01200096 378807 CATSPER4 CATSPER4 gene dto:DTO_01200097 Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008] 1536 CYBB NOX2 CYBB gene dto:DTO_01200098 221301 FAM26D C6orf78 FAM26D gene dto:DTO_01200099 254228 FAM26E C6orf188 FAM26E gene dto:DTO_01200100 A protein FAM26F that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5R3K3] 441168 FAM26F Protein FAM26F C6orf187 FAM26F gene dto:DTO_01200101 This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] 5349 FXYD3 MAT8 PLML FXYD3 gene dto:DTO_01200102 This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010] 53828 FXYD4 FXYD4 gene dto:DTO_01200103 This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009] 53827 FXYD5 DYSAD IWU1 FXYD5 gene dto:DTO_01200104 This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011] 100533181 53826 FXYD6 FXYD6 gene dto:DTO_01200105 This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000] 53822 FXYD7 FXYD7 gene dto:DTO_01200106 406875 FXYD6P3 FXYD8 FXYD6P3 gene dto:DTO_01200107 This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] 2554 GABRA1 GABRA1 gene dto:DTO_01200108 GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] 2555 GABRA2 GABRA2 gene dto:DTO_01200109 GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008] 2556 GABRA3 GABRA3 gene dto:DTO_01200110 Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011] 2557 GABRA4 GABRA4 gene dto:DTO_01200111 GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008] 2558 GABRA5 GABRA5 gene dto:DTO_01200112 GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008] 2559 GABRA6 GABRA6 gene dto:DTO_01200113 The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008] 2560 GABRB1 GABRB1 gene dto:DTO_01200114 The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008] 2561 GABRB2 GABRB2 gene dto:DTO_01200115 This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013] 2562 GABRB3 GABRB3 gene dto:DTO_01200116 Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] 2563 GABRD GABRD gene dto:DTO_01200117 The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008] 2564 GABRE GABRE gene dto:DTO_01200118 The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008] 2565 GABRG1 GABRG1 gene dto:DTO_01200119 This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] 2566 GABRG2 GABRG2 gene dto:DTO_01200120 This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012] 2567 GABRG3 GABRG3 gene dto:DTO_01200121 The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] 2568 GABRP GABRP gene dto:DTO_01200122 GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] 2569 GABRR1 GABRR1 gene dto:DTO_01200123 GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA receptor complex. [provided by RefSeq, Jul 2008] 2570 GABRR2 GABRR2 gene dto:DTO_01200124 The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012] 200959 GABRR3 GABRR3 gene dto:DTO_01200125 The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009] 55879 GABRQ GABRQ gene dto:DTO_01200126 The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] 2741 GLRA1 GLRA1 gene dto:DTO_01200127 The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010] 2742 GLRA2 GLRA2 gene dto:DTO_01200128 This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] 8001 GLRA3 GLRA3 gene dto:DTO_01200129 This gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. The encoded protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] 441509 GLRA4 GLRA4 gene dto:DTO_01200130 This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] 2743 GLRB GLRB gene dto:DTO_01200131 GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009] 51463 653519 GPR89A GPHRA GPR89 SH120 GPR89A gene dto:DTO_01200132 GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009] 51463 653519 GPR89B GPHRB GPR89B gene dto:DTO_01200133 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 2890 GRIA1 GLUH1 GLUR1 GRIA1 gene dto:DTO_01200134 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG-&gt;CGG; Q-&gt;R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] 2891 GRIA2 GLUR2 GRIA2 gene dto:DTO_01200135 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA-&gt;GGA; R-&gt;G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008] 2892 GRIA3 GLUR3 GLURC GRIA3 gene dto:DTO_01200136 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA-&gt;GGA; R-&gt;G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008] 2893 GRIA4 GLUR4 GRIA4 gene dto:DTO_01200137 This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009] 2894 GRID1 KIAA1220 GRID1 gene dto:DTO_01200138 The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014] 2895 GRID2 GLURD2 GRID2 gene dto:DTO_01200139 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG-&gt;CGG; Q-&gt;R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008] 2897 GRIK1 GLUR5 GRIK1 gene dto:DTO_01200140 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008] 2898 GRIK2 GLUR6 GRIK2 gene dto:DTO_01200141 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008] 2899 GRIK3 GLUR7 GRIK3 gene dto:DTO_01200142 This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] 2900 GRIK4 GRIK GRIK4 gene dto:DTO_01200143 This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] 2901 GRIK5 GRIK2 GRIK5 gene dto:DTO_01200144 The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011] 348980 HCN1 BCNG1 HCN1 gene dto:DTO_01200145 Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010] 610 HCN2 BCNG2 HCN2 gene dto:DTO_01200146 This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] 57657 HCN3 KIAA1535 HCN3 gene dto:DTO_01200147 This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008] 10021 HCN4 HCN4 gene dto:DTO_01200148 This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] 84329 HVCN1 VSOP HVCN1 gene dto:DTO_01200149 This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008] 3766 KCNJ10 KCNJ10 gene dto:DTO_01200150 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009] 3767 KCNJ11 KCNJ11 gene dto:DTO_01200151 This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] 3768 KCNJ12 IRK2 KCNJN1 KCNJ12 gene dto:DTO_01200152 This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] 3769 KCNJ13 KCNJ13 gene dto:DTO_01200153 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013] 3770 KCNJ14 IRK4 KCNJ14 gene dto:DTO_01200154 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013] 3772 KCNJ15 KCNJ14 KCNJ15 gene dto:DTO_01200155 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014] 3773 KCNJ16 KCNJ16 gene dto:DTO_01200156 This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic periodic paralysis. [provided by RefSeq, Jan 2013] 100134444 KCNJ18 KCNJ18 gene dto:DTO_01200157 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 3758 KCNJ1 ROMK1 KCNJ1 gene dto:DTO_01200158 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008] 3759 KCNJ2 IRK1 KCNJ2 gene dto:DTO_01200159 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012] 3760 KCNJ3 GIRK1 KCNJ3 gene dto:DTO_01200160 Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] 3761 KCNJ4 IRK3 KCNJ4 gene dto:DTO_01200161 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008] 3762 KCNJ5 GIRK4 KCNJ5 gene dto:DTO_01200162 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008] 3763 KCNJ6 GIRK2 KATP2 KCNJ7 KCNJ6 gene dto:DTO_01200163 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012] 3764 KCNJ8 KCNJ8 gene dto:DTO_01200164 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008] 3765 KCNJ9 GIRK3 KCNJ9 gene dto:DTO_01200165 This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009] 3708 ITPR1 INSP3R1 ITPR1 gene dto:DTO_01200166 3709 ITPR2 ITPR2 gene dto:DTO_01200167 This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010] 3710 ITPR3 ITPR3 gene dto:DTO_01200168 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008] 3744 KCNA10 KCNA10 gene dto:DTO_01200169 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008] 7881 KCNAB1 KCNA1B KCNAB1 gene dto:DTO_01200170 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010] 8514 KCNAB2 KCNA2B KCNK2 KCNAB2 gene dto:DTO_01200171 This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012] 9196 KCNAB3 KCNA3B KCNAB3 gene dto:DTO_01200172 KCNIP1 KCNIP1 gene dto:DTO_01200173 KCNIP2 KCNIP2 gene dto:DTO_01200174 This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] 80333 KCNIP4 CALP KCHIP4 KCNIP4 gene dto:DTO_01200175 MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 3778 KCNMA1 KCNMA SLO KCNMA1 gene dto:DTO_01200176 MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008] 3779 KCNMB1 KCNMB1 gene dto:DTO_01200177 MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013] 10242 KCNMB2 KCNMB2 gene dto:DTO_01200178 MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009] 27094 KCNMB3 KCNMB2 KCNMBL KCNMB3 gene dto:DTO_01200179 MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008] 27345 KCNMB4 KCNMB4 gene dto:DTO_01200180 This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008] 3736 KCNA1 KCNA1 gene dto:DTO_01200181 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008] 3737 KCNA2 KCNA2 gene dto:DTO_01200182 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008] 3738 KCNA3 HGK5 KCNA3 gene dto:DTO_01200183 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011] 3739 KCNA4 KCNA4L KCNA4 gene dto:DTO_01200184 Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012] 3741 KCNA5 KCNA5 gene dto:DTO_01200185 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008] 3742 KCNA6 KCNA6 gene dto:DTO_01200186 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008] 3743 KCNA7 KCNA7 gene dto:DTO_01200187 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008] 3745 KCNB1 KCNB1 gene dto:DTO_01200188 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008] 9312 KCNB2 KCNB2 gene dto:DTO_01200189 3746 KCNC1 KCNC1 gene dto:DTO_01200190 The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] 3747 KCNC2 KCNC2 gene dto:DTO_01200191 The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014] 3748 KCNC3 KCNC3 gene dto:DTO_01200192 The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] 3749 KCNC4 KCNC4 gene dto:DTO_01200193 This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013] 3750 KCND1 KCND1 gene dto:DTO_01200194 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008] 3751 KCND2 KIAA1044 KCND2 gene dto:DTO_01200195 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008] 3752 KCND3 KCND3 gene dto:DTO_01200196 The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] 3753 KCNE1 KCNE1 gene dto:DTO_01200197 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008] 9992 KCNE2 KCNE2 gene dto:DTO_01200198 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008] 10008 KCNE3 KCNE3 gene dto:DTO_01200199 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008] 23704 KCNE4 KCNE4 gene dto:DTO_01200200 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008] 3754 KCNF1 KCNF1 gene dto:DTO_01200201 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008] 3755 KCNG1 KCNG1 gene dto:DTO_01200202 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008] 26251 KCNG2 KCNF2 KCNG2 gene dto:DTO_01200203 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] 170850 KCNG3 KCNG3 gene dto:DTO_01200204 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008] 93107 KCNG4 KCNG3 KCNG4 gene dto:DTO_01200205 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] 3756 KCNH1 EAG EAG1 KCNH1 gene dto:DTO_01200206 This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] 3757 KCNH2 ERG ERG1 HERG KCNH2 gene dto:DTO_01200207 23416 KCNH3 KIAA1282 KCNH3 gene dto:DTO_01200208 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008] 23415 KCNH4 KCNH4 gene dto:DTO_01200209 This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] 27133 KCNH5 EAG2 KCNH5 gene dto:DTO_01200210 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] 81033 KCNH6 ERG2 KCNH6 gene dto:DTO_01200211 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008] 90134 KCNH7 ERG3 KCNH7 gene dto:DTO_01200212 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008] 131096 KCNH8 KCNH8 gene dto:DTO_01200213 This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008] 3775 KCNK1 HOHO1 KCNO1 TWIK1 KCNK1 gene dto:DTO_01200214 This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 3776 KCNK2 TREK TREK1 KCNK2 gene dto:DTO_01200215 This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008] 3777 KCNK3 TASK TASK1 KCNK3 gene dto:DTO_01200216 Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids. [provided by RefSeq, Jul 2008] 50801 KCNK4 TRAAK KCNK4 gene dto:DTO_01200217 This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008] 8645 KCNK5 TASK2 KCNK5 gene dto:DTO_01200218 This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008] 9424 KCNK6 TOSS TWIK2 KCNK6 gene dto:DTO_01200219 This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 10089 KCNK7 KCNK7 gene dto:DTO_01200220 This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] 51305 KCNK9 TASK3 KCNK9 gene dto:DTO_01200221 The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008] 54207 KCNK10 TREK2 KCNK10 gene dto:DTO_01200222 This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008] 56660 KCNK12 KCNK12 gene dto:DTO_01200223 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013] 56659 KCNK13 KCNK13 gene dto:DTO_01200224 This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008] 60598 KCNK15 TASK5 KCNK15 gene dto:DTO_01200225 The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008] 83795 KCNK16 TALK1 KCNK16 gene dto:DTO_01200226 The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] 89822 KCNK17 TALK2 TASK4 KCNK17 gene dto:DTO_01200227 Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011] 338567 KCNK18 TRESK TRIK KCNK18 gene dto:DTO_01200228 Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008] 3780 KCNN1 SK KCNN1 gene dto:DTO_01200229 Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] 3781 KCNN2 KCNN2 gene dto:DTO_01200230 Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] 3782 KCNN3 K3 KCNN3 gene dto:DTO_01200231 The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008] 3783 KCNN4 IK1 IKCA1 KCA4 SK4 KCNN4 gene dto:DTO_01200232 This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011] 3784 KCNQ1 KCNA8 KCNA9 KVLQT1 KCNQ1 gene dto:DTO_01200233 The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 3785 KCNQ2 KCNQ2 gene dto:DTO_01200234 This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014] 3786 KCNQ3 KCNQ3 gene dto:DTO_01200235 The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 9132 KCNQ4 KCNQ4 gene dto:DTO_01200236 This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] 56479 KCNQ5 KCNQ5 gene dto:DTO_01200237 Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008] 3787 KCNS1 KCNS1 gene dto:DTO_01200238 3788 KCNS2 KIAA1144 KCNS2 gene dto:DTO_01200239 Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] 3790 KCNS3 KCNS3 gene dto:DTO_01200240 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] 57582 KCNT1 KIAA1422 KCNT1 gene dto:DTO_01200241 343450 KCNT2 SLICK KCNT2 gene dto:DTO_01200242 157855 KCNU1 KCNMA3 KCNMC1 SLO3 KCNU1 gene dto:DTO_01200243 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008] 27012 KCNV1 KCNV1 gene dto:DTO_01200244 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008] 169522 KCNV2 KCNV2 gene dto:DTO_01200245 LRRC26 LRRC26 gene dto:DTO_01200246 LRRC38 LRRC38 gene dto:DTO_01200247 LRRC52 LRRC52 gene dto:DTO_01200248 LRRC55 LRRC55 gene dto:DTO_01200249 This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009] 57192 MCOLN1 ML4 MCOLN1 gene dto:DTO_01200250 Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009] 255231 MCOLN2 MCOLN2 gene dto:DTO_01200251 This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] 55283 MCOLN3 MCOLN3 gene dto:DTO_01200252 This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] 90550 MCU C10orf42 CCDC109A MCU gene dto:DTO_01200253 The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 23209 MLC1 KIAA0027 WKL1 MLC1 gene dto:DTO_01200254 NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008] 259232 NALCN VGCNL1 NALCN gene dto:DTO_01200255 This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008] 116443 GRIN3A KIAA1973 GRIN3A gene dto:DTO_01200256 116444 GRIN3B GRIN3B gene dto:DTO_01200257 This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] 2903 GRIN2A NMDAR2A GRIN2A gene dto:DTO_01200258 N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008] 2904 GRIN2B NMDAR2B GRIN2B gene dto:DTO_01200259 This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] 2905 GRIN2C NMDAR2C GRIN2C gene dto:DTO_01200260 N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010] 2906 GRIN2D GluN2D NMDAR2D GRIN2D gene dto:DTO_01200261 The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] 2902 GRIN1 NMDAR1 GRIN1 gene dto:DTO_01200262 This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012] 27035 NOX1 MOX1 NOH1 NOX1 gene dto:DTO_01200263 This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] 79400 NOX5 NOX5 gene dto:DTO_01200264 The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013] 5023 P2RX1 P2X1 P2RX1 gene dto:DTO_01200265 The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013] 22953 P2RX2 P2X2 P2RX2 gene dto:DTO_01200266 The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008] 5024 P2RX3 P2RX3 gene dto:DTO_01200267 The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012] 5025 P2RX4 P2RX4 gene dto:DTO_01200268 The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011] 5026 P2RX5 P2X5 P2RX5 gene dto:DTO_01200269 The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009] 9127 P2RX6 P2RXL1 P2X6 P2RX6 gene dto:DTO_01200270 The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010] 5027 P2RX7 P2RX7 gene dto:DTO_01200271 The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008] 24145 PANX1 MRS1 PANX1 gene dto:DTO_01200272 The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] 56666 PANX2 PANX2 gene dto:DTO_01200273 The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008] 116337 PANX3 PANX3 gene dto:DTO_01200274 Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010] 9780 PIEZO1 FAM38A KIAA0233 PIEZO1 gene dto:DTO_01200275 The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014] 63895 PIEZO2 C18orf30 C18orf58 FAM38B PIEZO2 gene dto:DTO_01200276 This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] 114780 PKD1L2 KIAA1879 PC1L2 PKD1L2 gene dto:DTO_01200277 This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009] 342372 PKD1L3 PKD1L3 gene dto:DTO_01200278 This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] 9033 PKD2L1 PKD2L PKDL TRPP3 PKD2L1 gene dto:DTO_01200279 27039 PKD2L2 PKD2L2 gene dto:DTO_01200280 This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011] 5311 PKD2 PKD2 gene dto:DTO_01200281 This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008] 10343 PKDREJ PKDREJ gene dto:DTO_01200282 PLLP PLLP gene dto:DTO_01200283 This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008] 5348 FXYD1 PLM FXYD1 gene dto:DTO_01200284 This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] 6261 RYR1 RYDR RYR1 gene dto:DTO_01200285 This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008] 6262 RYR2 RYR2 gene dto:DTO_01200286 The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] 6263 RYR3 HBRR RYR3 gene dto:DTO_01200287 This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008] 10861 SLC26A1 SAT1 SLC26A1 gene dto:DTO_01200288 This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013] 65010 SLC26A6 SLC26A6 gene dto:DTO_01200289 The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.[provided by RefSeq, Jan 2011] 6323 SCN1A NAC1 SCN1 SCN1A gene dto:DTO_01200290 Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] 6324 SCN1B SCN1B gene dto:DTO_01200291 Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] 6326 SCN2A NAC2 SCN2A1 SCN2A2 SCN2A gene dto:DTO_01200292 6327 SCN2B SCN2B gene dto:DTO_01200293 Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 6328 SCN3A KIAA1356 NAC3 SCN3A gene dto:DTO_01200294 Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] 55800 SCN3B KIAA1158 SCN3B gene dto:DTO_01200295 Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008] 6329 SCN4A SCN4A gene dto:DTO_01200296 The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009] 6330 SCN4B SCN4B gene dto:DTO_01200297 The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] 6331 SCN5A SCN5A gene dto:DTO_01200298 This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011] 6332 SCN7A SCN6A SCN7A gene dto:DTO_01200299 This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] 6334 SCN8A MED SCN8A gene dto:DTO_01200300 This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009] 6335 SCN9A NENA SCN9A gene dto:DTO_01200301 The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] 6336 SCN10A SCN10A gene dto:DTO_01200302 Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004] 11280 SCN11A SCN12A SNS2 SCN11A gene dto:DTO_01200303 Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009] 6337 SCNN1A SCNN1 SCNN1A gene dto:DTO_01200304 Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009] 6338 SCNN1B SCNN1B gene dto:DTO_01200305 6339 SCNN1D DNACH SCNN1D gene dto:DTO_01200306 Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009] 6340 SCNN1G SCNN1G gene dto:DTO_01200307 79041 TMEM38A TMEM38A gene dto:DTO_01200308 This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012] 55151 TMEM38B C9orf87 TMEM38B gene dto:DTO_01200309 This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008] 117531 TMC1 TMC1 gene dto:DTO_01200310 This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial for normal auditory function. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Jul 2008] 117532 TMC2 C20orf145 TMC2 gene dto:DTO_01200311 342125 TMC3 TMC3 gene dto:DTO_01200312 147798 TMC4 TMC4 gene dto:DTO_01200313 79838 TMC5 TMC5 gene dto:DTO_01200314 Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008] 11322 TMC6 EVER1 EVIN1 TMC6 gene dto:DTO_01200315 79905 TMC7 TMC7 gene dto:DTO_01200316 Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008] 147138 TMC8 EVER2 EVIN2 TMC8 gene dto:DTO_01200317 Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008] 53373 TPCN1 KIAA1169 TPC1 TPCN1 gene dto:DTO_01200318 This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009] 219931 TPCN2 TPC2 TPCN2 gene dto:DTO_01200319 The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008] 8989 TRPA1 ANKTM1 TRPA1 gene dto:DTO_01200320 The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] 7220 TRPC1 TRP1 TRPC1 gene dto:DTO_01200321 The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] 7222 TRPC3 TRP3 TRPC3 gene dto:DTO_01200322 This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] 7223 TRPC4 TRPC4 gene dto:DTO_01200323 This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010] 7224 TRPC5 TRP5 TRPC5 gene dto:DTO_01200324 The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009] 7225 TRPC6 TRP6 TRPC6 gene dto:DTO_01200325 57113 TRPC7 TRP7 TRPC7 gene dto:DTO_01200326 This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] 4308 TRPM1 LTRPC1 MLSN MLSN1 TRPM1 gene dto:DTO_01200327 The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008] 7226 TRPM2 EREG1 KNP3 LTRPC2 TRPC7 TRPM2 gene dto:DTO_01200328 The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 80036 TRPM3 KIAA1616 LTRPC3 TRPM3 gene dto:DTO_01200329 The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010] 54795 TRPM4 LTRPC4 TRPM4 gene dto:DTO_01200330 This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010] 29850 TRPM5 LTRPC5 MTR1 TRPM5 gene dto:DTO_01200331 The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014] 54822 TRPM7 CHAK1 LTRPC7 TRPM7 gene dto:DTO_01200332 79054 TRPM8 LTRPC6 TRPP8 TRPM8 gene dto:DTO_01200333 Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008] 7442 TRPV1 VR1 TRPV1 gene dto:DTO_01200334 This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008] 51393 TRPV2 VRL TRPV2 gene dto:DTO_01200335 This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] 162514 TRPV3 TRPV3 gene dto:DTO_01200336 This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] 59341 TRPV4 VRL2 VROAC TRPV4 gene dto:DTO_01200337 This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008] 56302 TRPV5 ECAC1 TRPV5 gene dto:DTO_01200338 This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Jul 2013] 55503 TRPV6 ECAC2 TRPV6 gene dto:DTO_01200339 This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011] 57348 TTYH1 TTYH1 gene dto:DTO_01200340 This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] 94015 TTYH2 C17orf29 TTYH2 gene dto:DTO_01200341 This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008] 80727 TTYH3 KIAA1691 TTYH3 gene dto:DTO_01200342 LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008] 353174 ZACN L2 LGICZ LGICZ1 ZAC ZACN gene dto:DTO_01200343 PKD1L1 PKD1L1 gene dto:DTO_01300327 Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. https://en.wikipedia.org/wiki/Ion_channel Ion channel dto:DTO_01300328 Neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family dto:DTO_01300329 Calcium-dependent chloride channel (ca-clc) family dto:DTO_01300330 Amiloride-sensitive sodium channel family dto:DTO_01300331 Anion channel-forming bestrophin (bestrophin) family dto:DTO_01300332 Calcium channel auxiliary subunit 2 types 1-4 (cca-2) family dto:DTO_01300333 Calcium channel alpha-1 subunit family dto:DTO_01300334 Calcium channel auxiliary subunit types 1-4 (cca-) family dto:DTO_01300335 Calcium homeostasis modulator calcium channel (calhm-c) family dto:DTO_01300336 Calcium channel auxiliary subunit 1-8 (cca) family dto:DTO_01300337 PMP-22/EMP/MP20 family dto:DTO_01300338 ABCC family dto:DTO_01300339 Epithelial chloride channel (e-clc) family dto:DTO_01300340 Intracellular chloride channel (icc) family dto:DTO_01300341 Chloride channel family dto:DTO_01300342 Intracellular chloride channel (clic) family dto:DTO_01300343 Cyclic nucleotide-gated cation channel family dto:DTO_01300344 Calcium release-activated calcium (crac) channel (crac-c) family dto:DTO_01300345 Cation channel sperm-associated family dto:DTO_01300346 Phagocyte (gp91(phox)) nadph oxidase family dto:DTO_01300347 FAM26 family dto:DTO_01300348 Fxyd family dto:DTO_01300349 Phospholemman (plm) family dto:DTO_01300350 Golgi pH regulator family dto:DTO_01300351 Glutamate-gated ion channel (GIC) Family of Neurotransmitter Receptors dto:DTO_01300352 Voltage-gated proton channel (vpc) family dto:DTO_01300353 Inward rectifier-type potassium channel family dto:DTO_01300354 Ryanodine-inositol 1,4,5-triphosphate receptor calcium channel (rir-cac) family dto:DTO_01300355 Potassium channel family dto:DTO_01300356 Voltage-gated potassium channel -subunit (kv) family dto:DTO_01300357 The phagocyte (gp91(phox)) nadph oxidase family dto:DTO_01300358 Calcium-activated potassium channel auxiliary subunit slowpoke- (slo) family dto:DTO_01300359 Two pore domain potassium channel family dto:DTO_01300360 Transient receptor potential calcium channel (TRP-CC) family dto:DTO_01300361 MCU family dto:DTO_01300362 Membrane protein mlc1 family dto:DTO_01300363 Cation-nonselective channel family dto:DTO_01300364 Atp-gated p2x receptor cation channel (p2x receptor) family dto:DTO_01300365 Gap junction-forming innexin (innexin) family dto:DTO_01300366 Mechanical nociceptor, piezo (piezo) family dto:DTO_01300367 Polycystin cation channel (pcc) family dto:DTO_01300368 SLC26A/SulP transporter family dto:DTO_01300369 Sodium channel family dto:DTO_01300370 Sodium channel auxiliary subunit 1-4 (sca-) family dto:DTO_01300371 Tmem38 family dto:DTO_01300372 Transmembrane channel (TMC) family dto:DTO_01300373 Anion channel tweety (tweety) family dto:DTO_01300374 5-hydroxytryptamine receptor subfamily dto:DTO_01300375 Acetylcholine receptor subfamily dto:DTO_01300376 Acid-sensing ion channel 1 (ASIC1) subfamily dto:DTO_01300377 Acid-sensing ion channel 2 (ASIC2) subfamily dto:DTO_01300378 Acid-sensing ion channel 3 (ASIC3) subfamily dto:DTO_01300379 Acid-sensing ion channel 4 (ASIC4) subfamily dto:DTO_01300380 Acid-sensing ion channel 5 (ASIC5) subfamily dto:DTO_01300381 CACNA1A subfamily dto:DTO_01300382 CACNA1B subfamily dto:DTO_01300383 CACNA1C subfamily dto:DTO_01300384 CACNA1D subfamily dto:DTO_01300385 CACNA1E subfamily dto:DTO_01300386 CACNA1F subfamily dto:DTO_01300387 CACNA1G subfamily dto:DTO_01300388 CACNA1H subfamily dto:DTO_01300389 CACNA1I subfamily dto:DTO_01300390 CACNA1S subfamily dto:DTO_01300391 CACNG subfamily dto:DTO_01300392 CFTR transporter subfamily dto:DTO_01300393 CLCNKA subfamily dto:DTO_01300394 CLCNKB subfamily dto:DTO_01300395 ClC-1/CLCN1 subfamily dto:DTO_01300396 ClC-2/CLCN2 subfamily dto:DTO_01300397 ClC-3/CLCN3 subfamily dto:DTO_01300398 ClC-4/CLCN4 subfamily dto:DTO_01300399 ClC-5/CLCN5 subfamily dto:DTO_01300400 ClC-6/CLCN6 subfamily dto:DTO_01300401 ClC-7/CLCN7 subfamily dto:DTO_01300402 CNGA1 subfamily dto:DTO_01300403 CNGA2 subfamily dto:DTO_01300404 CNGA3 subfamily dto:DTO_01300405 CNGA4 subfamily dto:DTO_01300406 CNGB1 subfamily dto:DTO_01300407 CNGB3 subfamily dto:DTO_01300408 Gamma-aminobutyric acid receptor subfamily dto:DTO_01300409 Glycine receptor subfamily dto:DTO_01300410 GRIA1 subfamily dto:DTO_01300411 GRIA2 subfamily dto:DTO_01300412 GRIA3 subfamily dto:DTO_01300413 GRIA4 subfamily dto:DTO_01300414 GRID1 subfamily dto:DTO_01300415 GRID2 subfamily dto:DTO_01300416 GRIK1 subfamily dto:DTO_01300417 GRIK2 subfamily dto:DTO_01300418 GRIK3 subfamily dto:DTO_01300419 GRIK4 subfamily dto:DTO_01300420 GRIK5 subfamily dto:DTO_01300421 KCNJ10 subfamily dto:DTO_01300422 KCNJ11 subfamily dto:DTO_01300423 KCNJ12 subfamily dto:DTO_01300424 KCNJ13 subfamily dto:DTO_01300425 KCNJ14 subfamily dto:DTO_01300426 KCNJ15 subfamily dto:DTO_01300427 KCNJ16 subfamily dto:DTO_01300428 KCNJ1 subfamily dto:DTO_01300429 KCNJ2 subfamily dto:DTO_01300430 KCNJ3 subfamily dto:DTO_01300431 KCNJ4 subfamily dto:DTO_01300432 KCNJ5 subfamily dto:DTO_01300433 KCNJ6 subfamily dto:DTO_01300434 KCNJ8 subfamily dto:DTO_01300435 KCNJ9 subfamily dto:DTO_01300436 A (Shaker) subfamily dto:DTO_01300437 Calcium-activated subfamily dto:DTO_01300438 KCNMB/KCNMB1 subfamily dto:DTO_01300439 KCNMB/KCNMB2 subfamily dto:DTO_01300440 KCNMB/KCNMB3 subfamily dto:DTO_01300441 KCNMB/KCNMB4 subfamily dto:DTO_01300442 B (Shab) subfamily dto:DTO_01300443 C (Shaw) subfamily dto:DTO_01300444 D (Shal) subfamily dto:DTO_01300445 KCNE subfamily dto:DTO_01300446 F subfamily dto:DTO_01300447 G subfamily dto:DTO_01300448 H (Eag) subfamily dto:DTO_01300449 KQT subfamily dto:DTO_01300450 S subfamily dto:DTO_01300451 V subfamily dto:DTO_01300452 Polycystin subfamily dto:DTO_01300453 NR3A/GRIN3A subfamily dto:DTO_01300454 NR3B/GRIN3B subfamily dto:DTO_01300455 NR2A/GRIN2A subfamily dto:DTO_01300456 NR2B/GRIN2B subfamily dto:DTO_01300457 NR2C/GRIN2C subfamily dto:DTO_01300458 NR2D/GRIN2D subfamily dto:DTO_01300459 NR1/GRIN1 subfamily dto:DTO_01300460 RYR1 subfamily dto:DTO_01300461 RYR2 subfamily dto:DTO_01300462 RYR3 subfamily dto:DTO_01300463 Nav1.1/SCN1A subfamily dto:DTO_01300464 SCN1B family dto:DTO_01300465 Nav1.2/SCN2A subfamily dto:DTO_01300466 SCN2B family dto:DTO_01300467 Nav1.3/SCN3A subfamily dto:DTO_01300468 SCN3B family dto:DTO_01300469 Nav1.4/SCN4A subfamily dto:DTO_01300470 SCN4B family dto:DTO_01300471 Nav1.5/SCN5A subfamily dto:DTO_01300472 SCN7A subfamily dto:DTO_01300473 Nav1.6/SCN8A subfamily dto:DTO_01300474 Nav1.7/SCN9A subfamily dto:DTO_01300475 Nav1.8/SCN10A subfamily dto:DTO_01300476 Nav1.9/SCN11A subfamily dto:DTO_01300477 SCNN1A subfamily dto:DTO_01300478 SCNN1B subfamily dto:DTO_01300479 SCNN1D subfamily dto:DTO_01300480 SCNN1G subfamily dto:DTO_01300481 Two pore calcium channel subfamily dto:DTO_01300482 STrpC subfamily dto:DTO_01300483 LTrpC subfamily dto:DTO_01300484 TrpV subfamily dto:DTO_01300490 Alpha-10/CHRNA10 sub-subfamily dto:DTO_01300491 Alpha-2/CHRNA2 sub-subfamily dto:DTO_01300492 Alpha-3/CHRNA3 sub-subfamily dto:DTO_01300493 Alpha-4/CHRNA4 sub-subfamily dto:DTO_01300494 Alpha-5/CHRNA5 sub-subfamily dto:DTO_01300495 Alpha-6/CHRNA6 sub-subfamily dto:DTO_01300496 Alpha-7/CHRNA7 sub-subfamily dto:DTO_01300497 Alpha-9/CHRNA9 sub-subfamily dto:DTO_01300498 Alpha-1/CHRNA1 sub-subfamily dto:DTO_01300499 Beta-2/CHRNB2 sub-subfamily dto:DTO_01300500 Beta-3/CHRNB3 sub-subfamily dto:DTO_01300501 Beta-4/CHRNB4 sub-subfamily dto:DTO_01300502 Beta-1/CHRNB1 sub-subfamily dto:DTO_01300503 Delta/CHRND sub-subfamily dto:DTO_01300504 Epsilon/CHRNE sub-subfamily dto:DTO_01300505 Gamma/CHRNG sub-subfamily dto:DTO_01300506 GABRA1 sub-subfamily dto:DTO_01300507 GABRA2 sub-subfamily dto:DTO_01300508 GABRA3 sub-subfamily dto:DTO_01300509 GABRA4 sub-subfamily dto:DTO_01300510 GABRA5 sub-subfamily dto:DTO_01300511 GABRA6 sub-subfamily dto:DTO_01300512 GABRB1 sub-subfamily dto:DTO_01300513 GABRB2 sub-subfamily dto:DTO_01300514 GABRB3 sub-subfamily dto:DTO_01300515 GABRD sub-subfamily dto:DTO_01300516 GABRE sub-subfamily dto:DTO_01300517 GABRG1 sub-subfamily dto:DTO_01300518 GABRG2 sub-subfamily dto:DTO_01300519 GABRG3 sub-subfamily dto:DTO_01300520 GABRP sub-subfamily dto:DTO_01300521 GABRR1 sub-subfamily dto:DTO_01300522 GABRR2 sub-subfamily dto:DTO_01300523 GABRR3 sub-subfamily dto:DTO_01300524 GABRQ sub-subfamily dto:DTO_01300525 GLRA1 sub-subfamily dto:DTO_01300526 GLRA2 sub-subfamily dto:DTO_01300527 GLRA3 sub-subfamily dto:DTO_01300528 GLRA4 sub-subfamily dto:DTO_01300529 GLRB sub-subfamily dto:DTO_01300530 Kv1.8/KCNA10 sub-subfamily dto:DTO_01300531 KCa1.1/KCNMA1 sub-subfamily dto:DTO_01300532 Kv1.1/KCNA1 sub-subfamily dto:DTO_01300533 Kv1.2/KCNA2 sub-subfamily dto:DTO_01300534 Kv1.3/KCNA3 sub-subfamily dto:DTO_01300535 Kv1.4/KCNA4 sub-subfamily dto:DTO_01300536 Kv1.5/KCNA5 sub-subfamily dto:DTO_01300537 Kv1.6/KCNA6 sub-subfamily dto:DTO_01300538 Kv1.7/KCNA7 sub-subfamily dto:DTO_01300539 Kv2.1/KCNB1 sub-subfamily dto:DTO_01300540 Kv2.2/KCNB2 sub-subfamily dto:DTO_01300541 Kv3.1/KCNC1 sub-subfamily dto:DTO_01300542 Kv3.2/KCNC2 sub-subfamily dto:DTO_01300543 Kv3.3/KCNC3 sub-subfamily dto:DTO_01300544 Kv3.4/KCNC4 sub-subfamily dto:DTO_01300545 Kv4.1/KCND1 sub-subfamily dto:DTO_01300546 Kv4.2/KCND2 sub-subfamily dto:DTO_01300547 Kv4.3/KCND3 sub-subfamily dto:DTO_01300548 Kv5.1/KCNF1 sub-subfamily dto:DTO_01300549 Kv6.1/KCNG1 sub-subfamily dto:DTO_01300550 Kv6.2/KCNG2 sub-subfamily dto:DTO_01300551 Kv6.3/KCNG3 sub-subfamily dto:DTO_01300552 Kv6.4/KCNG4 sub-subfamily dto:DTO_01300553 Kv10.1/KCNH1 sub-subfamily dto:DTO_01300554 Kv11.1/KCNH2 sub-subfamily dto:DTO_01300555 Kv12.2/KCNH3 sub-subfamily dto:DTO_01300556 Kv12.3/KCNH4 sub-subfamily dto:DTO_01300557 Kv10.2/KCNH5 sub-subfamily dto:DTO_01300558 Kv11.2/KCNH6 sub-subfamily dto:DTO_01300559 Kv11.3/KCNH7 sub-subfamily dto:DTO_01300560 Kv12.1/KCNH8 sub-subfamily dto:DTO_01300561 Kv7.1/KCNQ1 sub-subfamily dto:DTO_01300562 Kv7.2/KCNQ2 sub-subfamily dto:DTO_01300563 Kv7.3/KCNQ3 sub-subfamily dto:DTO_01300564 Kv7.4/KCNQ4 sub-subfamily dto:DTO_01300565 Kv7.5/KCNQ5 sub-subfamily dto:DTO_01300566 Kv9.1/KCNS1 sub-subfamily dto:DTO_01300567 Kv9.2/KCNS2 sub-subfamily dto:DTO_01300568 Kv9.3/KCNS3 sub-subfamily dto:DTO_01300569 KCa4.1/KCNT1 sub-subfamily dto:DTO_01300570 KCa4.2/KCNT2 sub-subfamily dto:DTO_01300571 KCa5.1/KCNU1 sub-subfamily dto:DTO_01300572 Kv8.1/KCNV1 sub-subfamily dto:DTO_01300573 Kv8.2/KCNV2 sub-subfamily dto:DTO_01300574 MCOLN1 sub-subfamily dto:DTO_01300575 MCOLN2 sub-subfamily dto:DTO_01300576 MCOLN3 sub-subfamily dto:DTO_01300577 TRPC1 sub-subfamily dto:DTO_01300578 TRPC3 sub-subfamily dto:DTO_01300579 TRPC4 sub-subfamily dto:DTO_01300580 TRPC5 sub-subfamily dto:DTO_01300581 TRPC6 sub-subfamily dto:DTO_01300582 TRPC7 sub-subfamily dto:DTO_01300583 TRPM1 sub-subfamily dto:DTO_01300584 TRPM2 sub-subfamily dto:DTO_01300585 TRPM3 sub-subfamily dto:DTO_01300586 TRPM4 sub-subfamily dto:DTO_01300587 TRPM5 sub-subfamily dto:DTO_01300588 TRPM7 sub-subfamily dto:DTO_01300589 TRPM8 sub-subfamily dto:DTO_01300590 TRPV1 sub-subfamily dto:DTO_01300591 TRPV2 sub-subfamily dto:DTO_01300592 TRPV3 sub-subfamily dto:DTO_01300593 TRPV4 sub-subfamily dto:DTO_01300594 TRPV5 sub-subfamily dto:DTO_01300595 TRPV6 sub-subfamily dto:DTO_01309332 5-HT3 receptor sub-subfamily dto:DTO_01390001 Anion-transporting ion channel dto:DTO_01390002 Cation-transporting ion channel dto:DTO_01390003 Chloride channel dto:DTO_01390004 ligand-gated ion channel dto:DTO_01390005 sodium channel dto:DTO_01390006 Voltage-gated ion channel dto:DTO_01400327 Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. https://en.wikipedia.org/wiki/Ion_channel Ion channel gene dto:DTO_01400328 Neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family gene dto:DTO_01400329 Calcium-dependent chloride channel (ca-clc) family gene dto:DTO_01400330 Amiloride-sensitive sodium channel family gene dto:DTO_01400331 Anion channel-forming bestrophin (bestrophin) family gene dto:DTO_01400332 Calcium channel auxiliary subunit 2 types 1-4 (cca-2) family gene dto:DTO_01400333 Calcium channel alpha-1 subunit family gene dto:DTO_01400334 Calcium channel auxiliary subunit types 1-4 (cca-) family gene dto:DTO_01400335 Calcium homeostasis modulator calcium channel (calhm-c) family gene dto:DTO_01400336 Calcium channel auxiliary subunit 1-8 (cca) family gene dto:DTO_01400337 PMP-22/EMP/MP20 family gene dto:DTO_01400338 ABCC family gene dto:DTO_01400339 Epithelial chloride channel (e-clc) family gene dto:DTO_01400340 Intracellular chloride channel (icc) family gene dto:DTO_01400341 Chloride channel family gene dto:DTO_01400342 Intracellular chloride channel (clic) family gene dto:DTO_01400343 Cyclic nucleotide-gated cation channel family gene dto:DTO_01400344 Calcium release-activated calcium (crac) channel (crac-c) family gene dto:DTO_01400345 Cation channel sperm-associated family gene dto:DTO_01400346 Phagocyte (gp91(phox)) nadph oxidase family gene dto:DTO_01400347 FAM26 family gene dto:DTO_01400348 Fxyd family gene dto:DTO_01400349 Phospholemman (plm) family gene dto:DTO_01400350 Golgi pH regulator family gene dto:DTO_01400351 Glutamate-gated ion channel (GIC) Family of Neurotransmitter Receptors gene dto:DTO_01400352 Voltage-gated proton channel (vpc) family gene dto:DTO_01400353 Inward rectifier-type potassium channel family gene dto:DTO_01400354 Ryanodine-inositol 1,4,5-triphosphate receptor calcium channel (rir-cac) family gene dto:DTO_01400355 Potassium channel family gene dto:DTO_01400356 Voltage-gated potassium channel -subunit (kv) family gene dto:DTO_01400357 The phagocyte (gp91(phox)) nadph oxidase family gene dto:DTO_01400358 Calcium-activated potassium channel auxiliary subunit slowpoke- (slo) family gene dto:DTO_01400359 Two pore domain potassium channel family gene dto:DTO_01400360 Transient receptor potential calcium channel (TRP-CC) family gene dto:DTO_01400361 MCU family gene dto:DTO_01400362 Membrane protein mlc1 family gene dto:DTO_01400363 Cation-nonselective channel family gene dto:DTO_01400364 Atp-gated p2x receptor cation channel (p2x receptor) family gene dto:DTO_01400365 Gap junction-forming innexin (innexin) family gene dto:DTO_01400366 Mechanical nociceptor, piezo (piezo) family gene dto:DTO_01400367 Polycystin cation channel (pcc) family gene dto:DTO_01400368 SLC26A/SulP transporter family gene dto:DTO_01400369 Sodium channel family gene dto:DTO_01400370 Sodium channel auxiliary subunit 1-4 (sca-) family gene dto:DTO_01400371 Tmem38 family gene dto:DTO_01400372 Transmembrane channel (TMC) family gene dto:DTO_01400373 Anion channel tweety (tweety) family gene dto:DTO_01400374 5-hydroxytryptamine receptor subfamily gene dto:DTO_01400375 Acetylcholine receptor subfamily gene dto:DTO_01400376 Acid-sensing ion channel 1 (ASIC1) subfamily gene dto:DTO_01400377 Acid-sensing ion channel 2 (ASIC2) subfamily gene dto:DTO_01400378 Acid-sensing ion channel 3 (ASIC3) subfamily gene dto:DTO_01400379 Acid-sensing ion channel 4 (ASIC4) subfamily gene dto:DTO_01400380 Acid-sensing ion channel 5 (ASIC5) subfamily gene dto:DTO_01400381 CACNA1A subfamily gene dto:DTO_01400382 CACNA1B subfamily gene dto:DTO_01400383 CACNA1C subfamily gene dto:DTO_01400384 CACNA1D subfamily gene dto:DTO_01400385 CACNA1E subfamily gene dto:DTO_01400386 CACNA1F subfamily gene dto:DTO_01400387 CACNA1G subfamily gene dto:DTO_01400388 CACNA1H subfamily gene dto:DTO_01400389 CACNA1I subfamily gene dto:DTO_01400390 CACNA1S subfamily gene dto:DTO_01400391 CACNG subfamily gene dto:DTO_01400392 CFTR transporter subfamily gene dto:DTO_01400393 CLCNKA subfamily gene dto:DTO_01400394 CLCNKB subfamily gene dto:DTO_01400395 ClC-1/CLCN1 subfamily gene dto:DTO_01400396 ClC-2/CLCN2 subfamily gene dto:DTO_01400397 ClC-3/CLCN3 subfamily gene dto:DTO_01400398 ClC-4/CLCN4 subfamily gene dto:DTO_01400399 ClC-5/CLCN5 subfamily gene dto:DTO_01400400 ClC-6/CLCN6 subfamily gene dto:DTO_01400401 ClC-7/CLCN7 subfamily gene dto:DTO_01400402 CNGA1 subfamily gene dto:DTO_01400403 CNGA2 subfamily gene dto:DTO_01400404 CNGA3 subfamily gene dto:DTO_01400405 CNGA4 subfamily gene dto:DTO_01400406 CNGB1 subfamily gene dto:DTO_01400407 CNGB3 subfamily gene dto:DTO_01400408 Gamma-aminobutyric acid receptor subfamily gene dto:DTO_01400409 Glycine receptor subfamily gene dto:DTO_01400410 GRIA1 subfamily gene dto:DTO_01400411 GRIA2 subfamily gene dto:DTO_01400412 GRIA3 subfamily gene dto:DTO_01400413 GRIA4 subfamily gene dto:DTO_01400414 GRID1 subfamily gene dto:DTO_01400415 GRID2 subfamily gene dto:DTO_01400416 GRIK1 subfamily gene dto:DTO_01400417 GRIK2 subfamily gene dto:DTO_01400418 GRIK3 subfamily gene dto:DTO_01400419 GRIK4 subfamily gene dto:DTO_01400420 GRIK5 subfamily gene dto:DTO_01400421 KCNJ10 subfamily gene dto:DTO_01400422 KCNJ11 subfamily gene dto:DTO_01400423 KCNJ12 subfamily gene dto:DTO_01400424 KCNJ13 subfamily gene dto:DTO_01400425 KCNJ14 subfamily gene dto:DTO_01400426 KCNJ15 subfamily gene dto:DTO_01400427 KCNJ16 subfamily gene dto:DTO_01400428 KCNJ1 subfamily gene dto:DTO_01400429 KCNJ2 subfamily gene dto:DTO_01400430 KCNJ3 subfamily gene dto:DTO_01400431 KCNJ4 subfamily gene dto:DTO_01400432 KCNJ5 subfamily gene dto:DTO_01400433 KCNJ6 subfamily gene dto:DTO_01400434 KCNJ8 subfamily gene dto:DTO_01400435 KCNJ9 subfamily gene dto:DTO_01400436 A (Shaker) subfamily gene dto:DTO_01400437 Calcium-activated subfamily gene dto:DTO_01400438 KCNMB/KCNMB1 subfamily gene dto:DTO_01400439 KCNMB/KCNMB2 subfamily gene dto:DTO_01400440 KCNMB/KCNMB3 subfamily gene dto:DTO_01400441 KCNMB/KCNMB4 subfamily gene dto:DTO_01400442 B (Shab) subfamily gene dto:DTO_01400443 C (Shaw) subfamily gene dto:DTO_01400444 D (Shal) subfamily gene dto:DTO_01400445 KCNE subfamily gene dto:DTO_01400446 F subfamily gene dto:DTO_01400447 G subfamily gene dto:DTO_01400448 H (Eag) subfamily gene dto:DTO_01400449 KQT subfamily gene dto:DTO_01400450 S subfamily gene dto:DTO_01400451 V subfamily gene dto:DTO_01400452 Polycystin subfamily gene dto:DTO_01400453 NR3A/GRIN3A subfamily gene dto:DTO_01400454 NR3B/GRIN3B subfamily gene dto:DTO_01400455 NR2A/GRIN2A subfamily gene dto:DTO_01400456 NR2B/GRIN2B subfamily gene dto:DTO_01400457 NR2C/GRIN2C subfamily gene dto:DTO_01400458 NR2D/GRIN2D subfamily gene dto:DTO_01400459 NR1/GRIN1 subfamily gene dto:DTO_01400460 RYR1 subfamily gene dto:DTO_01400461 RYR2 subfamily gene dto:DTO_01400462 RYR3 subfamily gene dto:DTO_01400463 Nav1.1/SCN1A subfamily gene dto:DTO_01400464 SCN1B family gene dto:DTO_01400465 Nav1.2/SCN2A subfamily gene dto:DTO_01400466 SCN2B family gene dto:DTO_01400467 Nav1.3/SCN3A subfamily gene dto:DTO_01400468 SCN3B family gene dto:DTO_01400469 Nav1.4/SCN4A subfamily gene dto:DTO_01400470 SCN4B family gene dto:DTO_01400471 Nav1.5/SCN5A subfamily gene dto:DTO_01400472 SCN7A subfamily gene dto:DTO_01400473 Nav1.6/SCN8A subfamily gene dto:DTO_01400474 Nav1.7/SCN9A subfamily gene dto:DTO_01400475 Nav1.8/SCN10A subfamily gene dto:DTO_01400476 Nav1.9/SCN11A subfamily gene dto:DTO_01400477 SCNN1A subfamily gene dto:DTO_01400478 SCNN1B subfamily gene dto:DTO_01400479 SCNN1D subfamily gene dto:DTO_01400480 SCNN1G subfamily gene dto:DTO_01400481 Two pore calcium channel subfamily gene dto:DTO_01400482 STrpC subfamily gene dto:DTO_01400483 LTrpC subfamily gene dto:DTO_01400484 TrpV subfamily gene dto:DTO_01400490 Alpha-10/CHRNA10 sub-subfamily gene dto:DTO_01400491 Alpha-2/CHRNA2 sub-subfamily gene dto:DTO_01400492 Alpha-3/CHRNA3 sub-subfamily gene dto:DTO_01400493 Alpha-4/CHRNA4 sub-subfamily gene dto:DTO_01400494 Alpha-5/CHRNA5 sub-subfamily gene dto:DTO_01400495 Alpha-6/CHRNA6 sub-subfamily gene dto:DTO_01400496 Alpha-7/CHRNA7 sub-subfamily gene dto:DTO_01400497 Alpha-9/CHRNA9 sub-subfamily gene dto:DTO_01400498 Alpha-1/CHRNA1 sub-subfamily gene dto:DTO_01400499 Beta-2/CHRNB2 sub-subfamily gene dto:DTO_01400500 Beta-3/CHRNB3 sub-subfamily gene dto:DTO_01400501 Beta-4/CHRNB4 sub-subfamily gene dto:DTO_01400502 Beta-1/CHRNB1 sub-subfamily gene dto:DTO_01400503 Delta/CHRND sub-subfamily gene dto:DTO_01400504 Epsilon/CHRNE sub-subfamily gene dto:DTO_01400505 Gamma/CHRNG sub-subfamily gene dto:DTO_01400506 GABRA1 sub-subfamily gene dto:DTO_01400507 GABRA2 sub-subfamily gene dto:DTO_01400508 GABRA3 sub-subfamily gene dto:DTO_01400509 GABRA4 sub-subfamily gene dto:DTO_01400510 GABRA5 sub-subfamily gene dto:DTO_01400511 GABRA6 sub-subfamily gene dto:DTO_01400512 GABRB1 sub-subfamily gene dto:DTO_01400513 GABRB2 sub-subfamily gene dto:DTO_01400514 GABRB3 sub-subfamily gene dto:DTO_01400515 GABRD sub-subfamily gene dto:DTO_01400516 GABRE sub-subfamily gene dto:DTO_01400517 GABRG1 sub-subfamily gene dto:DTO_01400518 GABRG2 sub-subfamily gene dto:DTO_01400519 GABRG3 sub-subfamily gene dto:DTO_01400520 GABRP sub-subfamily gene dto:DTO_01400521 GABRR1 sub-subfamily gene dto:DTO_01400522 GABRR2 sub-subfamily gene dto:DTO_01400523 GABRR3 sub-subfamily gene dto:DTO_01400524 GABRQ sub-subfamily gene dto:DTO_01400525 GLRA1 sub-subfamily gene dto:DTO_01400526 GLRA2 sub-subfamily gene dto:DTO_01400527 GLRA3 sub-subfamily gene dto:DTO_01400528 GLRA4 sub-subfamily gene dto:DTO_01400529 GLRB sub-subfamily gene dto:DTO_01400530 Kv1.8/KCNA10 sub-subfamily gene dto:DTO_01400531 KCa1.1/KCNMA1 sub-subfamily gene dto:DTO_01400532 Kv1.1/KCNA1 sub-subfamily gene dto:DTO_01400533 Kv1.2/KCNA2 sub-subfamily gene dto:DTO_01400534 Kv1.3/KCNA3 sub-subfamily gene dto:DTO_01400535 Kv1.4/KCNA4 sub-subfamily gene dto:DTO_01400536 Kv1.5/KCNA5 sub-subfamily gene dto:DTO_01400537 Kv1.6/KCNA6 sub-subfamily gene dto:DTO_01400538 Kv1.7/KCNA7 sub-subfamily gene dto:DTO_01400539 Kv2.1/KCNB1 sub-subfamily gene dto:DTO_01400540 Kv2.2/KCNB2 sub-subfamily gene dto:DTO_01400541 Kv3.1/KCNC1 sub-subfamily gene dto:DTO_01400542 Kv3.2/KCNC2 sub-subfamily gene dto:DTO_01400543 Kv3.3/KCNC3 sub-subfamily gene dto:DTO_01400544 Kv3.4/KCNC4 sub-subfamily gene dto:DTO_01400545 Kv4.1/KCND1 sub-subfamily gene dto:DTO_01400546 Kv4.2/KCND2 sub-subfamily gene dto:DTO_01400547 Kv4.3/KCND3 sub-subfamily gene dto:DTO_01400548 Kv5.1/KCNF1 sub-subfamily gene dto:DTO_01400549 Kv6.1/KCNG1 sub-subfamily gene dto:DTO_01400550 Kv6.2/KCNG2 sub-subfamily gene dto:DTO_01400551 Kv6.3/KCNG3 sub-subfamily gene dto:DTO_01400552 Kv6.4/KCNG4 sub-subfamily gene dto:DTO_01400553 Kv10.1/KCNH1 sub-subfamily gene dto:DTO_01400554 Kv11.1/KCNH2 sub-subfamily gene dto:DTO_01400555 Kv12.2/KCNH3 sub-subfamily gene dto:DTO_01400556 Kv12.3/KCNH4 sub-subfamily gene dto:DTO_01400557 Kv10.2/KCNH5 sub-subfamily gene dto:DTO_01400558 Kv11.2/KCNH6 sub-subfamily gene dto:DTO_01400559 Kv11.3/KCNH7 sub-subfamily gene dto:DTO_01400560 Kv12.1/KCNH8 sub-subfamily gene dto:DTO_01400561 Kv7.1/KCNQ1 sub-subfamily gene dto:DTO_01400562 Kv7.2/KCNQ2 sub-subfamily gene dto:DTO_01400563 Kv7.3/KCNQ3 sub-subfamily gene dto:DTO_01400564 Kv7.4/KCNQ4 sub-subfamily gene dto:DTO_01400565 Kv7.5/KCNQ5 sub-subfamily gene dto:DTO_01400566 Kv9.1/KCNS1 sub-subfamily gene dto:DTO_01400567 Kv9.2/KCNS2 sub-subfamily gene dto:DTO_01400568 Kv9.3/KCNS3 sub-subfamily gene dto:DTO_01400569 KCa4.1/KCNT1 sub-subfamily gene dto:DTO_01400570 KCa4.2/KCNT2 sub-subfamily gene dto:DTO_01400571 KCa5.1/KCNU1 sub-subfamily gene dto:DTO_01400572 Kv8.1/KCNV1 sub-subfamily gene dto:DTO_01400573 Kv8.2/KCNV2 sub-subfamily gene dto:DTO_01400574 MCOLN1 sub-subfamily gene dto:DTO_01400575 MCOLN2 sub-subfamily gene dto:DTO_01400576 MCOLN3 sub-subfamily gene dto:DTO_01400577 TRPC1 sub-subfamily gene dto:DTO_01400578 TRPC3 sub-subfamily gene dto:DTO_01400579 TRPC4 sub-subfamily gene dto:DTO_01400580 TRPC5 sub-subfamily gene dto:DTO_01400581 TRPC6 sub-subfamily gene dto:DTO_01400582 TRPC7 sub-subfamily gene dto:DTO_01400583 TRPM1 sub-subfamily gene dto:DTO_01400584 TRPM2 sub-subfamily gene dto:DTO_01400585 TRPM3 sub-subfamily gene dto:DTO_01400586 TRPM4 sub-subfamily gene dto:DTO_01400587 TRPM5 sub-subfamily gene dto:DTO_01400588 TRPM7 sub-subfamily gene dto:DTO_01400589 TRPM8 sub-subfamily gene dto:DTO_01400590 TRPV1 sub-subfamily gene dto:DTO_01400591 TRPV2 sub-subfamily gene dto:DTO_01400592 TRPV3 sub-subfamily gene dto:DTO_01400593 TRPV4 sub-subfamily gene dto:DTO_01400594 TRPV5 sub-subfamily gene dto:DTO_01400595 TRPV6 sub-subfamily gene dto:DTO_01409932 5-HT3 receptor sub-subfamily gene dto:DTO_02100001 A 5-hydroxytryptamine receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08908] https://pharos.nih.gov/idg/targets/P08908 HTR1A ADRB2RL1 ADRBRL1 P08908 5-hydroxytryptamine receptor 1a dto:DTO_02100002 A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28222] https://pharos.nih.gov/idg/targets/P28222 HTR1B HTR1DB P28222 5-hydroxytryptamine receptor 1b dto:DTO_02100003 A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28221] https://pharos.nih.gov/idg/targets/P28221 HTR1D HTR1DA HTRL P28221 5-hydroxytryptamine receptor 1D dto:DTO_02100004 A 5-hydroxytryptamine receptor 1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28566] https://pharos.nih.gov/idg/targets/P28566 HTR1E P28566 5-hydroxytryptamine receptor 1E dto:DTO_02100005 A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30939] https://pharos.nih.gov/idg/targets/P30939 HTR1F HTR1EL P30939 5-hydroxytryptamine receptor 1f dto:DTO_02100006 A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28223] https://pharos.nih.gov/idg/targets/P28223 HTR2A HTR2 P28223 5-hydroxytryptamine receptor 2A dto:DTO_02100007 A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41595] https://pharos.nih.gov/idg/targets/P41595 HTR2B P41595 5-hydroxytryptamine receptor 2B dto:DTO_02100008 A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28335] https://pharos.nih.gov/idg/targets/P28335 HTR2C HTR1C P28335 5-hydroxytryptamine receptor 2c dto:DTO_02100009 A 5-hydroxytryptamine receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13639] https://pharos.nih.gov/idg/targets/Q13639 HTR4 Q13639 5-hydroxytryptamine receptor 4 dto:DTO_02100010 A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47898] https://pharos.nih.gov/idg/targets/P47898 HTR5A P47898 5-hydroxytryptamine receptor 5a dto:DTO_02100011 A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50406] https://pharos.nih.gov/idg/targets/P50406 HTR6 P50406 5-hydroxytryptamine receptor 6 dto:DTO_02100012 A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34969] https://pharos.nih.gov/idg/targets/P34969 HTR7 P34969 5-hydroxytryptamine receptor 7 dto:DTO_02100013 An adenosine receptor A1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30542] https://pharos.nih.gov/idg/targets/P30542 ADORA1 P30542 Adenosine receptor a1 dto:DTO_02100014 An adenosine receptor A2a that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29274] https://pharos.nih.gov/idg/targets/P29274 ADORA2A ADORA2 P29274 Adenosine receptor a2a dto:DTO_02100015 An adenosine receptor A2b that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29275] https://pharos.nih.gov/idg/targets/P29275 ADORA2B P29275 Adenosine receptor a2b dto:DTO_02100016 https://pharos.nih.gov/idg/targets/P0DMS8 ADORA3 P0DMS8 Adenosine receptor a3 dto:DTO_02100017 A duffy antigen/chemokine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16570] https://pharos.nih.gov/idg/targets/Q16570 ACKR1 DARC FY GPD Q16570 Atypical chemokine receptor 1 dto:DTO_02100018 A chemokine-binding protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00590] https://pharos.nih.gov/idg/targets/O00590 ACKR2 CCBP2 CCR10 CMKBR9 D6 O00590 Atypical chemokine receptor 2 dto:DTO_02100019 A C-X-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25106] https://pharos.nih.gov/idg/targets/P25106 ACKR3 CMKOR1 CXCR7 GPR159 RDC1 P25106 Atypical chemokine receptor 3 dto:DTO_02100020 A C-C chemokine receptor type 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPB9] https://pharos.nih.gov/idg/targets/Q9NPB9 ACKR4 CCBP2 CCR11 CCRL1 VSHK1 Q9NPB9 Atypical chemokine receptor 4 dto:DTO_02100021 A muscarinic acetylcholine receptor M1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P11229] https://pharos.nih.gov/idg/targets/P11229 CHRM1 P11229 Muscarinic acetylcholine receptor m1 dto:DTO_02100022 A muscarinic acetylcholine receptor M2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08172] https://pharos.nih.gov/idg/targets/P08172 CHRM2 P08172 Muscarinic acetylcholine receptor m2 dto:DTO_02100023 A muscarinic acetylcholine receptor M3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P20309] https://pharos.nih.gov/idg/targets/P20309 CHRM3 P20309 Muscarinic acetylcholine receptor m3 dto:DTO_02100024 A muscarinic acetylcholine receptor M4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08173] https://pharos.nih.gov/idg/targets/P08173 CHRM4 P08173 Muscarinic acetylcholine receptor m4 dto:DTO_02100025 A muscarinic acetylcholine receptor M5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08912] https://pharos.nih.gov/idg/targets/P08912 CHRM5 P08912 Muscarinic acetylcholine receptor M5 dto:DTO_02100026 An adrenocorticotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01718] https://pharos.nih.gov/idg/targets/Q01718 MC2R ACTHR Q01718 Adrenocorticotropic hormone receptor dto:DTO_02100027 An alpha-1A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35348] https://pharos.nih.gov/idg/targets/P35348 ADRA1A ADRA1C P35348 Alpha-1a adrenergic receptor dto:DTO_02100028 An alpha-1B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35368] https://pharos.nih.gov/idg/targets/P35368 ADRA1B P35368 Alpha-1B adrenergic receptor dto:DTO_02100029 An alpha-1D adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25100] https://pharos.nih.gov/idg/targets/P25100 ADRA1D ADRA1A P25100 Alpha-1D adrenergic receptor dto:DTO_02100030 An alpha-2A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08913] https://pharos.nih.gov/idg/targets/P08913 ADRA2A ADRA2R ADRAR P08913 Alpha-2a adrenergic receptor dto:DTO_02100031 An alpha-2B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18089] https://pharos.nih.gov/idg/targets/P18089 ADRA2B ADRA2L1 ADRA2RL1 P18089 Alpha-2B adrenergic receptor dto:DTO_02100032 An alpha-2C adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18825] https://pharos.nih.gov/idg/targets/P18825 ADRA2C ADRA2L2 ADRA2RL2 P18825 Alpha-2c adrenergic receptor dto:DTO_02100033 A beta-1 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08588] https://pharos.nih.gov/idg/targets/P08588 ADRB1 ADRB1R B1AR P08588 Beta-1 adrenergic receptor dto:DTO_02100034 A beta-2 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07550] https://pharos.nih.gov/idg/targets/P07550 ADRB2 ADRB2R B2AR P07550 Beta-2 adrenergic receptor dto:DTO_02100035 A beta-3 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P13945] https://pharos.nih.gov/idg/targets/P13945 ADRB3 ADRB3R B3AR P13945 Beta-3 adrenergic receptor dto:DTO_02100036 An angiotensin II receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30556] https://pharos.nih.gov/idg/targets/P30556 AGTR1 AGTR1A AGTR1B AT2R1 AT2R1B P30556 Type-1 angiotensin II receptor dto:DTO_02100037 An angiotensin II receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50052] https://pharos.nih.gov/idg/targets/P50052 AGTR2 P50052 Type-2 angiotensin II receptor dto:DTO_02100038 An apelin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35414] https://pharos.nih.gov/idg/targets/P35414 APLNR AGTRL1 APJ P35414 Apelin receptor dto:DTO_02100039 A brain-specific angiogenesis inhibitor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14514] https://pharos.nih.gov/idg/targets/O14514 BAI1 ADGRB1 O14514 Brain-specific angiogenesis inhibitor 1 dto:DTO_02100040 A brain-specific angiogenesis inhibitor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60241] https://pharos.nih.gov/idg/targets/O60241 BAI2 ADGRB2 O60241 Adhesion G protein-coupled receptor B2 dto:DTO_02100041 A brain-specific angiogenesis inhibitor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60242] https://pharos.nih.gov/idg/targets/O60242 BAI3 ADGRB3 KIAA0550 O60242 Adhesion G protein-coupled receptor B3 dto:DTO_02100042 A B1 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46663] https://pharos.nih.gov/idg/targets/P46663 BDKRB1 BRADYB1 P46663 B1 bradykinin receptor dto:DTO_02100043 A B2 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30411] https://pharos.nih.gov/idg/targets/P30411 BDKRB2 BKR2 P30411 B2 bradykinin receptor dto:DTO_02100044 A bombesin receptor subtype-3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32247] https://pharos.nih.gov/idg/targets/P32247 BRS3 P32247 Bombesin receptor subtype-3 dto:DTO_02100045 A C3a anaphylatoxin chemotactic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16581] https://pharos.nih.gov/idg/targets/Q16581 C3AR1 AZ3B C3R1 HNFAG09 Q16581 C3a anaphylatoxin chemotactic receptor dto:DTO_02100046 A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21730] https://pharos.nih.gov/idg/targets/P21730 C5AR1 C5AR C5R1 P21730 C5a anaphylatoxin chemotactic receptor 1 dto:DTO_02100047 A C5a anaphylatoxin chemotactic receptor C5L2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P296] https://pharos.nih.gov/idg/targets/Q9P296 C5AR2 C5L2 GPR77 Q9P296 C5a anaphylatoxin chemotactic receptor 2 dto:DTO_02100048 A calcitonin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30988] https://pharos.nih.gov/idg/targets/P30988 CALCR P30988 Calcitonin receptor dto:DTO_02100049 A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16602] https://pharos.nih.gov/idg/targets/Q16602 CALCRL CGRPR Q16602 Calcitonin gene-related peptide type 1 receptor dto:DTO_02100050 An extracellular calcium-sensing receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41180] https://pharos.nih.gov/idg/targets/P41180 CASR GPRC2A PCAR1 P41180 Extracellular calcium-sensing receptor dto:DTO_02100051 A cholecystokinin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32238] https://pharos.nih.gov/idg/targets/P32238 CCKAR CCKRA P32238 Cholecystokinin receptor type a dto:DTO_02100052 A C-C chemokine receptor type 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46092] https://pharos.nih.gov/idg/targets/P46092 CCR10 GPR2 P46092 C-c chemokine receptor type 10 dto:DTO_02100053 A C-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32246] https://pharos.nih.gov/idg/targets/P32246 CCR1 CMKBR1 CMKR1 SCYAR1 P32246 C-c chemokine receptor type 1 dto:DTO_02100054 A C-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41597] https://pharos.nih.gov/idg/targets/P41597 CCR2 CMKBR2 P41597 C-C chemokine receptor type 2 dto:DTO_02100055 A C-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51677] https://pharos.nih.gov/idg/targets/P51677 CCR3 CMKBR3 P51677 C-C chemokine receptor type 3 dto:DTO_02100056 A C-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51679] https://pharos.nih.gov/idg/targets/P51679 CCR4 CMKBR4 P51679 C-C chemokine receptor type 4 dto:DTO_02100057 A C-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51681] https://pharos.nih.gov/idg/targets/P51681 CCR5 CMKBR5 P51681 C-C chemokine receptor type 5 dto:DTO_02100058 A C-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51684] https://pharos.nih.gov/idg/targets/P51684 CCR6 CKRL3 CMKBR6 GPR29 STRL22 P51684 C-C chemokine receptor type 6 dto:DTO_02100059 A C-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32248] https://pharos.nih.gov/idg/targets/P32248 CCR7 CMKBR7 EBI1 EVI1 P32248 C-c chemokine receptor type 7 dto:DTO_02100060 A C-C chemokine receptor type 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51685] https://pharos.nih.gov/idg/targets/P51685 CCR8 CKRL1 CMKBR8 CMKBRL2 P51685 C-c chemokine receptor type 8 dto:DTO_02100061 A C-C chemokine receptor type 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51686] https://pharos.nih.gov/idg/targets/P51686 CCR9 GPR28 P51686 C-c chemokine receptor type 9 dto:DTO_02100062 A C-C chemokine receptor-like 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00421] https://pharos.nih.gov/idg/targets/O00421 CCRL2 CCR11 CCR6 CKRX CRAM HCR O00421 C-C chemokine receptor-like 2 dto:DTO_02100063 A CD97 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48960] https://pharos.nih.gov/idg/targets/P48960 CD97 ADGRE5 P48960 CD97 antigen dto:DTO_02100064 A cadherin EGF LAG seven-pass G-type receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ6] https://pharos.nih.gov/idg/targets/Q9NYQ6 CELSR1 CDHF9 FMI2 Q9NYQ6 Cadherin egf lag seven-pass g-type receptor 1 dto:DTO_02100065 A cadherin EGF LAG seven-pass G-type receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCU4] https://pharos.nih.gov/idg/targets/Q9HCU4 CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Q9HCU4 Cadherin egf lag seven-pass g-type receptor 2 dto:DTO_02100066 A cadherin EGF LAG seven-pass G-type receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ7] https://pharos.nih.gov/idg/targets/Q9NYQ7 CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2 Q9NYQ7 Cadherin EGF LAG seven-pass G-type receptor 3 dto:DTO_02100067 A cysteinyl leukotriene receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y271] https://pharos.nih.gov/idg/targets/Q9Y271 CYSLTR1 CYSLT1 Q9Y271 Cysteinyl leukotriene receptor 1 dto:DTO_02100068 A cysteinyl leukotriene receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS75] https://pharos.nih.gov/idg/targets/Q9NS75 CYSLTR2 CYSLT2 CYSLT2R Q9NS75 Cysteinyl leukotriene receptor 2 dto:DTO_02100069 A chemokine receptor-like protein CMKLR1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99788] https://pharos.nih.gov/idg/targets/Q99788 CMKLR1 CHEMR23 DEZ Q99788 Chemokine-like receptor 1 dto:DTO_02100070 A cannabinoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21554] https://pharos.nih.gov/idg/targets/P21554 CNR1 CNR P21554 Cannabinoid receptor 1 dto:DTO_02100071 A cannabinoid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34972] https://pharos.nih.gov/idg/targets/P34972 CNR2 CB2A CB2B P34972 Cannabinoid receptor 2 dto:DTO_02100072 A corticotropin-releasing factor receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34998] https://pharos.nih.gov/idg/targets/P34998 CRHR1 CRFR CRFR1 CRHR P34998 Corticotropin-releasing factor receptor 1 dto:DTO_02100073 A corticotropin-releasing factor receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13324] https://pharos.nih.gov/idg/targets/Q13324 CRHR2 CRF2R CRH2R Q13324 Corticotropin-releasing factor receptor 2 dto:DTO_02100074 A CX3C chemokine receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49238] https://pharos.nih.gov/idg/targets/P49238 CX3CR1 CMKBRL1 GPR13 P49238 CX3C chemokine receptor 1 dto:DTO_02100075 A C-X-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25024] https://pharos.nih.gov/idg/targets/P25024 CXCR1 CMKAR1 IL8RA P25024 C-X-C chemokine receptor type 1 dto:DTO_02100076 A C-X-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25025] https://pharos.nih.gov/idg/targets/P25025 CXCR2 IL8RB P25025 C-X-C chemokine receptor type 2 dto:DTO_02100077 A C-X-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49682] https://pharos.nih.gov/idg/targets/P49682 CXCR3 GPR9 P49682 C-x-c chemokine receptor type 3 dto:DTO_02100078 A C-X-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P61073] https://pharos.nih.gov/idg/targets/P61073 CXCR4 P61073 C-x-c chemokine receptor type 4 dto:DTO_02100079 A C-X-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32302] https://pharos.nih.gov/idg/targets/P32302 CXCR5 BLR1 MDR15 P32302 C-x-c chemokine receptor type 5 dto:DTO_02100080 A C-X-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_14906] https://pharos.nih.gov/idg/targets/O00574 CXCR6 BONZO STRL33 TYMSTR O00574 C-x-c chemokine receptor type 6 dto:DTO_02100081 A D(1A) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21728] https://pharos.nih.gov/idg/targets/P21728 DRD1 P21728 D(1a) dopamine receptor dto:DTO_02100082 A D(2) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P14416] https://pharos.nih.gov/idg/targets/P14416 DRD2 P14416 D(2) dopamine receptor dto:DTO_02100083 A D(3) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35462] https://pharos.nih.gov/idg/targets/P35462 DRD3 P35462 D(3) dopamine receptor dto:DTO_02100084 A D(4) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21917] https://pharos.nih.gov/idg/targets/P21917 DRD4 P21917 D(4) dopamine receptor dto:DTO_02100085 A D(1B) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21918] https://pharos.nih.gov/idg/targets/P21918 DRD5 DRD1B DRD1L2 P21918 D(1B) dopamine receptor dto:DTO_02100086 An endothelin-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25101] https://pharos.nih.gov/idg/targets/P25101 EDNRA ETA ETRA P25101 Endothelin-1 receptor dto:DTO_02100087 An endothelin B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24530] https://pharos.nih.gov/idg/targets/P24530 EDNRB ETRB P24530 Endothelin b receptor dto:DTO_02100088 An EGF, latrophilin and seven transmembrane domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBW9] https://pharos.nih.gov/idg/targets/Q9HBW9 ELTD1 ADGRL4 ETL Q9HBW9 Adhesion G protein-coupled receptor L4 dto:DTO_02100089 An EGF-like module-containing mucin-like hormone receptor-like 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14246] https://pharos.nih.gov/idg/targets/Q14246 EMR1 ADGRE1 TM7LN3 Q14246 Adhesion G protein-coupled receptor E1 dto:DTO_02100090 An EGF-like module-containing mucin-like hormone receptor-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHX3] https://pharos.nih.gov/idg/targets/Q9UHX3 EMR2 ADGRE2 Q9UHX3 Adhesion G protein-coupled receptor E2 dto:DTO_02100091 An EGF-like module-containing mucin-like hormone receptor-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BY15] https://pharos.nih.gov/idg/targets/Q9BY15 EMR3 ADGRE3 Q9BY15 Adhesion G protein-coupled receptor E3 dto:DTO_02100092 https://pharos.nih.gov/idg/targets/Q86SQ3 EMR4P ADGRE4P EMR4 GPR127 PGR16 Q86SQ3 Putative adhesion G protein-coupled receptor E4P dto:DTO_02100093 A prosaposin receptor GPR37L1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60883] https://pharos.nih.gov/idg/targets/O60883 GPR37L1 ETBRLP2 O60883 Prosaposin receptor GPR37L1 dto:DTO_02100094 A free fatty acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14842] https://pharos.nih.gov/idg/targets/O14842 FFAR1 GPR40 O14842 Free fatty acid receptor 1 dto:DTO_02100095 A free fatty acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15552] https://pharos.nih.gov/idg/targets/O15552 FFAR2 FFA2 GPCR43 GPR43 O15552 Free fatty acid receptor 2 dto:DTO_02100096 A free fatty acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14843] https://pharos.nih.gov/idg/targets/O14843 FFAR3 GPR41 O14843 Free fatty acid receptor 3 dto:DTO_02100097 A free fatty acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5NUL3] https://pharos.nih.gov/idg/targets/Q5NUL3 FFAR4 GPR120 GPR129 O3FAR1 PGR4 Q5NUL3 Free fatty acid receptor 4 dto:DTO_02100098 An fMet-Leu-Phe receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21462] https://pharos.nih.gov/idg/targets/P21462 FPR1 P21462 FMet-Leu-Phe receptor dto:DTO_02100099 An N-formyl peptide receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25090] https://pharos.nih.gov/idg/targets/P25090 FPR2 FPRH1 FPRL1 LXA4R P25090 N-formyl peptide receptor 2 dto:DTO_02100100 An N-formyl peptide receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25089] https://pharos.nih.gov/idg/targets/P25089 FPR3 FPRH1 FPRL2 P25089 N-formyl peptide receptor 3 dto:DTO_02100101 A follitropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P23945] https://pharos.nih.gov/idg/targets/P23945 FSHR LGR1 P23945 Follicle-stimulating hormone receptor dto:DTO_02100102 A frizzled-10 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULW2] https://pharos.nih.gov/idg/targets/Q9ULW2 FZD10 Q9ULW2 Frizzled-10 dto:DTO_02100103 A frizzled-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UP38] https://pharos.nih.gov/idg/targets/Q9UP38 FZD1 Q9UP38 Frizzled-1 dto:DTO_02100104 A frizzled-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14332] https://pharos.nih.gov/idg/targets/Q14332 FZD2 Q14332 Frizzled-2 dto:DTO_02100105 A frizzled-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPG1] https://pharos.nih.gov/idg/targets/Q9NPG1 FZD3 Q9NPG1 Frizzled-3 dto:DTO_02100106 A frizzled-4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULV1] https://pharos.nih.gov/idg/targets/Q9ULV1 FZD4 Q9ULV1 Frizzled-4 dto:DTO_02100107 A frizzled-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13467] https://pharos.nih.gov/idg/targets/Q13467 FZD5 C2orf31 Q13467 Frizzled-5 dto:DTO_02100108 A frizzled-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60353] https://pharos.nih.gov/idg/targets/O60353 FZD6 O60353 Frizzled-6 dto:DTO_02100109 A frizzled-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75084] https://pharos.nih.gov/idg/targets/O75084 FZD7 O75084 Frizzled-7 dto:DTO_02100110 A frizzled-8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H461] https://pharos.nih.gov/idg/targets/Q9H461 FZD8 Q9H461 Frizzled-8 dto:DTO_02100111 A frizzled-9 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00144] https://pharos.nih.gov/idg/targets/O00144 FZD9 FZD3 O00144 Frizzled-9 dto:DTO_02100112 An integral membrane protein GPR137 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96N19] https://pharos.nih.gov/idg/targets/Q96N19 GPR137 C11orf4 GPR137A TM7SF1L1 Q96N19 Integral membrane protein GPR137 dto:DTO_02100113 A gamma-aminobutyric acid type B receptor subunit 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBS5] https://pharos.nih.gov/idg/targets/Q9UBS5 GABBR1 GPRC3A Q9UBS5 Gamma-aminobutyric acid type B receptor subunit 1 dto:DTO_02100114 A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75899] https://pharos.nih.gov/idg/targets/O75899 GABBR2 GPR51 GPRC3B O75899 Gamma-aminobutyric acid type b receptor subunit 2 dto:DTO_02100115 A galanin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47211] https://pharos.nih.gov/idg/targets/P47211 GALR1 GALNR GALNR1 P47211 Galanin receptor type 1 dto:DTO_02100116 A galanin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43603] https://pharos.nih.gov/idg/targets/O43603 GALR2 GALNR2 O43603 Galanin receptor type 2 dto:DTO_02100117 A galanin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60755] https://pharos.nih.gov/idg/targets/O60755 GALR3 GALNR3 O60755 Galanin receptor type 3 dto:DTO_02100118 A cholecystokinin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32239] https://pharos.nih.gov/idg/targets/P32239 CCKBR CCKRB P32239 Gastrin/cholecystokinin type B receptor dto:DTO_02100119 A growth hormone-releasing hormone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02643] https://pharos.nih.gov/idg/targets/Q02643 GHRHR Q02643 Growth hormone-releasing hormone receptor dto:DTO_02100120 A growth hormone secretagogue receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92847] https://pharos.nih.gov/idg/targets/Q92847 GHSR Q92847 Growth hormone secretagogue receptor type 1 dto:DTO_02100121 A gastric inhibitory polypeptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48546] https://pharos.nih.gov/idg/targets/P48546 GIPR P48546 Gastric inhibitory polypeptide receptor dto:DTO_02100122 A glucagon-like peptide 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43220] https://pharos.nih.gov/idg/targets/P43220 GLP1R P43220 Glucagon-like peptide 1 receptor dto:DTO_02100123 A glucagon-like peptide 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95838] https://pharos.nih.gov/idg/targets/O95838 GLP2R O95838 Glucagon-like peptide 2 receptor dto:DTO_02100124 A glucagon receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47871] https://pharos.nih.gov/idg/targets/P47871 GCGR P47871 Glucagon receptor dto:DTO_02100125 A gonadotropin-releasing hormone I receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30968] https://pharos.nih.gov/idg/targets/P30968 GNRHR GRHR P30968 Gonadotropin-releasing hormone receptor dto:DTO_02100126 A gonadotropin-releasing hormone II receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P88] https://pharos.nih.gov/idg/targets/Q96P88 GNRHR2 Q96P88 Putative gonadotropin-releasing hormone ii receptor dto:DTO_02100127 A G-protein coupled receptor 101 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P66] https://pharos.nih.gov/idg/targets/Q96P66 GPR101 Q96P66 Probable G-protein coupled receptor 101 dto:DTO_02100128 A protein GPR107 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VW38] https://pharos.nih.gov/idg/targets/Q5VW38 GPR107 KIAA1624 LUSTR1 Q5VW38 Protein gpr107 dto:DTO_02100129 A G-protein coupled receptor 110 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T601] https://pharos.nih.gov/idg/targets/Q5T601 GPR110 ADGRF1 PGR19 Q5T601 Adhesion G-protein coupled receptor F1 dto:DTO_02100130 A G-protein coupled receptor 111 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF7] https://pharos.nih.gov/idg/targets/Q8IZF7 GPR111 ADGRF2 PGR20 Q8IZF7 Adhesion G-protein coupled receptor F2 dto:DTO_02100131 A G-protein coupled receptor 112 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF6] https://pharos.nih.gov/idg/targets/Q8IZF6 GPR112 ADGRG4 Q8IZF6 Adhesion G-protein coupled receptor G4 dto:DTO_02100132 A G-protein coupled receptor 113 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF5] https://pharos.nih.gov/idg/targets/Q8IZF5 GPR113 ADGRF3 PGR23 Q8IZF5 Adhesion G-protein coupled receptor F3 dto:DTO_02100133 A G-protein coupled receptor 114 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF4] https://pharos.nih.gov/idg/targets/Q8IZF4 GPR114 ADGRG5 PGR27 Q8IZF4 Adhesion G-protein coupled receptor G5 dto:DTO_02100134 A G-protein coupled receptor 115 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF3] https://pharos.nih.gov/idg/targets/Q8IZF3 GPR115 ADGRF4 PGR18 Q8IZF3 Adhesion G protein-coupled receptor F4 dto:DTO_02100135 A G-protein coupled receptor 116 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF2] https://pharos.nih.gov/idg/targets/Q8IZF2 GPR116 ADGRF5 KIAA0758 Q8IZF2 Adhesion G protein-coupled receptor F5 dto:DTO_02100136 A glucose-dependent insulinotropic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV5] https://pharos.nih.gov/idg/targets/Q8TDV5 GPR119 Q8TDV5 Glucose-dependent insulinotropic receptor dto:DTO_02100137 A G-protein coupled receptor 123 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SQ6] https://pharos.nih.gov/idg/targets/Q86SQ6 GPR123 ADGRA1 KIAA1828 Q86SQ6 Adhesion G protein-coupled receptor A1 dto:DTO_02100138 A G-protein coupled receptor 124 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PE1] https://pharos.nih.gov/idg/targets/Q96PE1 GPR124 ADGRA2 KIAA1531 TEM5 Q96PE1 G-protein coupled receptor 124 dto:DTO_02100139 A G-protein coupled receptor 125 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWK6] https://pharos.nih.gov/idg/targets/Q8IWK6 GPR125 ADGRA3 Q8IWK6 Adhesion G protein-coupled receptor A3 dto:DTO_02100140 A G-protein coupled receptor 126 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86SQ4] https://pharos.nih.gov/idg/targets/Q86SQ4 GPR126 ADGRG6 DREG VIGR Q86SQ4 G-protein coupled receptor 126 dto:DTO_02100141 A G-protein coupled receptor 128 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96K78] https://pharos.nih.gov/idg/targets/Q96K78 GPR128 ADGRG7 Q96K78 Adhesion G-protein coupled receptor G7 dto:DTO_02100142 A G-protein coupled receptor 132 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UNW8] https://pharos.nih.gov/idg/targets/Q9UNW8 GPR132 G2A Q9UNW8 Probable g-protein coupled receptor 132 dto:DTO_02100143 A G-protein coupled receptor 133 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QNK2] https://pharos.nih.gov/idg/targets/Q6QNK2 GPR133 ADGRD1 PGR25 Q6QNK2 Adhesion G-protein coupled receptor D1 dto:DTO_02100144 A G-protein coupled receptor 135 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IZ08] https://pharos.nih.gov/idg/targets/Q8IZ08 GPR135 Q8IZ08 Probable g-protein coupled receptor 135 dto:DTO_02100145 A G-protein coupled receptor 139 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6DWJ6] https://pharos.nih.gov/idg/targets/Q6DWJ6 GPR139 GPRG1 PGR3 Q6DWJ6 Probable G-protein coupled receptor 139 dto:DTO_02100146 A G-protein coupled receptor 141 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z602] https://pharos.nih.gov/idg/targets/Q7Z602 GPR141 PGR13 Q7Z602 Probable g-protein coupled receptor 141 dto:DTO_02100147 A G-protein coupled receptor 142 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z601] https://pharos.nih.gov/idg/targets/Q7Z601 GPR142 PGR2 Q7Z601 Probable G-protein coupled receptor 142 dto:DTO_02100148 A G-protein coupled receptor 143 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51810] https://pharos.nih.gov/idg/targets/P51810 GPR143 OA1 P51810 G-protein coupled receptor 143 dto:DTO_02100149 A G-protein coupled receptor 144 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z7M1] https://pharos.nih.gov/idg/targets/Q7Z7M1 GPR144 ADGRD2 PGR24 Q7Z7M1 Adhesion G-protein coupled receptor D2 dto:DTO_02100150 A G-protein coupled receptor 146 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96CH1] https://pharos.nih.gov/idg/targets/Q96CH1 GPR146 PGR8 Q96CH1 Probable g-protein coupled receptor 146 dto:DTO_02100151 A G-protein coupled receptor 148 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV2] https://pharos.nih.gov/idg/targets/Q8TDV2 GPR148 BTR PGR6 Q8TDV2 Probable G-protein coupled receptor 148 dto:DTO_02100152 A G-protein coupled receptor 149 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SP6] https://pharos.nih.gov/idg/targets/Q86SP6 GPR149 PGR10 Q86SP6 Probable g-protein coupled receptor 149 dto:DTO_02100153 A G-protein coupled receptor 150 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NGU9] https://pharos.nih.gov/idg/targets/Q8NGU9 GPR150 Q8NGU9 Probable g-protein coupled receptor 150 dto:DTO_02100154 A G-protein coupled receptor 151 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV0] https://pharos.nih.gov/idg/targets/Q8TDV0 GPR151 PGR7 Q8TDV0 Probable G-protein coupled receptor 151 dto:DTO_02100155 A G-protein coupled receptor 152 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDT2] https://pharos.nih.gov/idg/targets/Q8TDT2 GPR152 PGR5 Q8TDT2 Probable g-protein coupled receptor 152 dto:DTO_02100156 A G-protein coupled receptor 153 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6NV75] https://pharos.nih.gov/idg/targets/Q6NV75 GPR153 PGR1 Q6NV75 Probable g-protein coupled receptor 153 dto:DTO_02100157 A G-protein coupled receptor 156 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFN8] https://pharos.nih.gov/idg/targets/Q8NFN8 GPR156 GABABL PGR28 Q8NFN8 Probable G-protein coupled receptor 156 dto:DTO_02100158 A G-protein coupled receptor 157 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5UAW9] https://pharos.nih.gov/idg/targets/Q5UAW9 GPR157 Q5UAW9 Probable g-protein coupled receptor 157 dto:DTO_02100159 A G-protein coupled receptor 158 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T848] https://pharos.nih.gov/idg/targets/Q5T848 GPR158 KIAA1136 Q5T848 Probable g-protein coupled receptor 158 dto:DTO_02100160 A G-protein coupled receptor 160 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UJ42] https://pharos.nih.gov/idg/targets/Q9UJ42 GPR160 GPCR150 Q9UJ42 Probable G-protein coupled receptor 160 dto:DTO_02100161 A G-protein coupled receptor 161 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8N6U8] https://pharos.nih.gov/idg/targets/Q8N6U8 GPR161 Q8N6U8 G-protein coupled receptor 161 dto:DTO_02100162 A G-protein coupled receptor 162 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16538] https://pharos.nih.gov/idg/targets/Q16538 GPR162 GRCA Q16538 Probable g-protein coupled receptor 162 dto:DTO_02100163 A G-protein coupled receptor 171 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14626] https://pharos.nih.gov/idg/targets/O14626 GPR171 H963 O14626 Probable g-protein coupled receptor 171 dto:DTO_02100164 A G-protein coupled receptor 173 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS66] https://pharos.nih.gov/idg/targets/Q9NS66 GPR173 SREB3 Q9NS66 Probable g-protein coupled receptor 173 dto:DTO_02100165 A G-protein coupled receptor 174 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC1] https://pharos.nih.gov/idg/targets/Q9BXC1 GPR174 Q9BXC1 Probable G-protein coupled receptor 174 dto:DTO_02100166 A G-protein coupled receptor 176 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14439] https://pharos.nih.gov/idg/targets/Q14439 GPR176 Q14439 Probable g-protein coupled receptor 176 dto:DTO_02100167 A G-protein coupled receptor 179 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PRD1] https://pharos.nih.gov/idg/targets/Q6PRD1 GPR179 GPR158L GPR158L1 Q6PRD1 Probable G-protein coupled receptor 179 dto:DTO_02100168 A G-protein coupled receptor 182 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15218] https://pharos.nih.gov/idg/targets/O15218 GPR182 ADMR O15218 G-protein coupled receptor 182 dto:DTO_02100169 A G-protein coupled receptor 183 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32249] https://pharos.nih.gov/idg/targets/P32249 GPR183 EBI2 P32249 G-protein coupled receptor 183 dto:DTO_02100170 A G-protein coupled bile acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU6] https://pharos.nih.gov/idg/targets/Q8TDU6 GPBAR1 TGR5 Q8TDU6 G-protein coupled bile acid receptor 1 dto:DTO_02100171 https://pharos.nih.gov/idg/targets/Q8NGA4 GPR32P1 Q8NGA4 Putative G-protein coupled receptor GPR32P1 dto:DTO_02100172 A G-protein coupled receptor family C group 5 member B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZH0] https://pharos.nih.gov/idg/targets/Q9NZH0 GPRC5B RAIG2 Q9NZH0 G-protein coupled receptor family C group 5 member B dto:DTO_02100173 A G-protein coupled receptor family C group 5 member C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ84] https://pharos.nih.gov/idg/targets/Q9NQ84 GPRC5C RAIG3 Q9NQ84 G-protein coupled receptor family c group 5 member c dto:DTO_02100174 A G-protein coupled receptor family C group 5 member D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZD1] https://pharos.nih.gov/idg/targets/Q9NZD1 GPRC5D Q9NZD1 G-protein coupled receptor family c group 5 member d dto:DTO_02100175 A G-protein coupled receptor family C group 6 member A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T6X5] https://pharos.nih.gov/idg/targets/Q5T6X5 GPRC6A Q5T6X5 G-protein coupled receptor family c group 6 member a dto:DTO_02100176 A G-protein coupled estrogen receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99527] https://pharos.nih.gov/idg/targets/Q99527 GPER1 CEPR CMKRL2 DRY12 GPER GPR30 Q99527 G-protein coupled estrogen receptor 1 dto:DTO_02100177 A G-protein coupled receptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47775] https://pharos.nih.gov/idg/targets/P47775 GPR12 P47775 G-protein coupled receptor 12 dto:DTO_02100178 A G-protein coupled receptor 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49685] https://pharos.nih.gov/idg/targets/P49685 GPR15 P49685 G-protein coupled receptor 15 dto:DTO_02100179 A uracil nucleotide/cysteinyl leukotriene receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13304] https://pharos.nih.gov/idg/targets/Q13304 GPR17 Q13304 Uracil nucleotide/cysteinyl leukotriene receptor dto:DTO_02100180 An N-arachidonyl glycine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14330] https://pharos.nih.gov/idg/targets/Q14330 GPR18 GPCRW Q14330 N-arachidonyl glycine receptor dto:DTO_02100181 A G-protein coupled receptor 19 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15760] https://pharos.nih.gov/idg/targets/Q15760 GPR19 Q15760 Probable g-protein coupled receptor 19 dto:DTO_02100182 A G-protein coupled receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46091] https://pharos.nih.gov/idg/targets/P46091 GPR1 P46091 G-protein coupled receptor 1 dto:DTO_02100183 A G-protein coupled receptor 20 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99678] https://pharos.nih.gov/idg/targets/Q99678 GPR20 Q99678 G-protein coupled receptor 20 dto:DTO_02100184 A G-protein coupled receptor 21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99679] https://pharos.nih.gov/idg/targets/Q99679 GPR21 Q99679 Probable g-protein coupled receptor 21 dto:DTO_02100185 A G-protein coupled receptor 22 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99680] https://pharos.nih.gov/idg/targets/Q99680 GPR22 Q99680 Probable g-protein coupled receptor 22 dto:DTO_02100186 A G-protein coupled receptor 25 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00155] https://pharos.nih.gov/idg/targets/O00155 GPR25 O00155 Probable g-protein coupled receptor 25 dto:DTO_02100187 A G-protein coupled receptor 26 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NDV2] https://pharos.nih.gov/idg/targets/Q8NDV2 GPR26 Q8NDV2 G-protein coupled receptor 26 dto:DTO_02100188 A G-protein coupled receptor 27 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS67] https://pharos.nih.gov/idg/targets/Q9NS67 GPR27 SREB1 Q9NS67 Probable g-protein coupled receptor 27 dto:DTO_02100189 A 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00270] https://pharos.nih.gov/idg/targets/O00270 GPR31 O00270 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor dto:DTO_02100190 A G-protein coupled receptor 32 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75388] https://pharos.nih.gov/idg/targets/O75388 GPR32 O75388 Probable G-protein coupled receptor 32 dto:DTO_02100191 A G-protein coupled receptor 33 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q49SQ1] https://pharos.nih.gov/idg/targets/Q49SQ1 GPR33 Q49SQ1 Probable G-protein coupled receptor 33 dto:DTO_02100192 A G-protein coupled receptor 34 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UPC5] https://pharos.nih.gov/idg/targets/Q9UPC5 GPR34 Q9UPC5 Probable G-protein coupled receptor 34 dto:DTO_02100193 A G-protein coupled receptor 35 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HC97] https://pharos.nih.gov/idg/targets/Q9HC97 GPR35 Q9HC97 G-protein coupled receptor 35 dto:DTO_02100194 A G-protein coupled receptor 37 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15354] https://pharos.nih.gov/idg/targets/O15354 GPR37 O15354 Prosaposin receptor gpr37 dto:DTO_02100195 A G-protein coupled receptor 39 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43194] https://pharos.nih.gov/idg/targets/O43194 GPR39 O43194 G-protein coupled receptor 39 dto:DTO_02100196 A G-protein coupled receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46089] https://pharos.nih.gov/idg/targets/P46089 GPR3 ACCA P46089 G-protein coupled receptor 3 dto:DTO_02100197 A G-protein coupled receptor 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15529] https://pharos.nih.gov/idg/targets/O15529 GPR42 GPR42P O15529 G-protein coupled receptor 42 dto:DTO_02100198 A G-protein coupled receptor 45 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y3] https://pharos.nih.gov/idg/targets/Q9Y5Y3 GPR45 Q9Y5Y3 Probable G-protein coupled receptor 45 dto:DTO_02100199 A G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46093] https://pharos.nih.gov/idg/targets/P46093 GPR4 GPR19 P46093 G-protein coupled receptor 4 dto:DTO_02100200 A G-protein coupled receptor 52 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T5] https://pharos.nih.gov/idg/targets/Q9Y2T5 GPR52 Q9Y2T5 Probable G-protein coupled receptor 52 dto:DTO_02100201 A G-protein coupled receptor 55 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T6] https://pharos.nih.gov/idg/targets/Q9Y2T6 GPR55 Q9Y2T6 G-protein coupled receptor 55 dto:DTO_02100202 A G-protein coupled receptor 56 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y653] https://pharos.nih.gov/idg/targets/Q9Y653 GPR56 ADGRG1 TM7LN4 TM7XN1 Q9Y653 G-protein coupled receptor 56 dto:DTO_02100203 A G-protein coupled receptor 61 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ8] https://pharos.nih.gov/idg/targets/Q9BZJ8 GPR61 BALGR Q9BZJ8 Probable G-protein coupled receptor 61 dto:DTO_02100204 A G-protein coupled receptor 62 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ7] https://pharos.nih.gov/idg/targets/Q9BZJ7 GPR62 Q9BZJ7 Probable g-protein coupled receptor 62 dto:DTO_02100205 A G-protein coupled receptor 63 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ6] https://pharos.nih.gov/idg/targets/Q9BZJ6 GPR63 PSP24B Q9BZJ6 Probable G-protein coupled receptor 63 dto:DTO_02100206 A G-protein coupled receptor 64 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZP9] https://pharos.nih.gov/idg/targets/Q8IZP9 GPR64 ADGRG2 HE6 TM7LN2 Q8IZP9 Adhesion G-protein coupled receptor G2 dto:DTO_02100207 A G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46095] https://pharos.nih.gov/idg/targets/P46095 GPR6 P46095 G-protein coupled receptor 6 dto:DTO_02100208 A G-protein coupled receptor 75 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95800] https://pharos.nih.gov/idg/targets/O95800 GPR75 O95800 Probable G-protein coupled receptor 75 dto:DTO_02100209 A G-protein coupled receptor 78 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P69] https://pharos.nih.gov/idg/targets/Q96P69 GPR78 Q96P69 G-protein coupled receptor 78 dto:DTO_02100210 A G-protein coupled receptor 82 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P67] https://pharos.nih.gov/idg/targets/Q96P67 GPR82 Q96P67 Probable g-protein coupled receptor 82 dto:DTO_02100211 A G-protein coupled receptor 83 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NYM4] https://pharos.nih.gov/idg/targets/Q9NYM4 GPR83 GPR72 KIAA1540 Q9NYM4 Probable g-protein coupled receptor 83 dto:DTO_02100212 A G-protein coupled receptor 84 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NQS5] https://pharos.nih.gov/idg/targets/Q9NQS5 GPR84 EX33 Q9NQS5 G-protein coupled receptor 84 dto:DTO_02100213 A G-protein coupled receptor 85 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P60893] https://pharos.nih.gov/idg/targets/P60893 GPR85 SREB2 P60893 Probable g-protein coupled receptor 85 dto:DTO_02100214 A G-protein coupled receptor 87 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BY21] https://pharos.nih.gov/idg/targets/Q9BY21 GPR87 GPR95 Q9BY21 G-protein coupled receptor 87 dto:DTO_02100215 A G-protein coupled receptor 88 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZN0] https://pharos.nih.gov/idg/targets/Q9GZN0 GPR88 STRG Q9GZN0 Probable g-protein coupled receptor 88 dto:DTO_02100216 A G-protein coupled receptor 97 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Y34] https://pharos.nih.gov/idg/targets/Q86Y34 GPR97 ADGRG3 PGR26 Q86Y34 Adhesion G protein-coupled receptor G3 dto:DTO_02100217 A G-protein coupled receptor 98 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXG9] https://pharos.nih.gov/idg/targets/Q8WXG9 GPR98 ADGRV1 KIAA0686 KIAA1943 MASS1 VLGR1 Q8WXG9 G-protein coupled receptor 98 dto:DTO_02100218 A metabotropic glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13255] https://pharos.nih.gov/idg/targets/Q13255 GRM1 GPRC1A MGLUR1 Q13255 Metabotropic glutamate receptor 1 dto:DTO_02100219 A metabotropic glutamate receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14416] https://pharos.nih.gov/idg/targets/Q14416 GRM2 GPRC1B MGLUR2 Q14416 Metabotropic glutamate receptor 2 dto:DTO_02100220 A metabotropic glutamate receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14832] https://pharos.nih.gov/idg/targets/Q14832 GRM3 GPRC1C MGLUR3 Q14832 Metabotropic glutamate receptor 3 dto:DTO_02100221 A metabotropic glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14833] https://pharos.nih.gov/idg/targets/Q14833 GRM4 GPRC1D MGLUR4 Q14833 Metabotropic glutamate receptor 4 dto:DTO_02100222 A metabotropic glutamate receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41594] https://pharos.nih.gov/idg/targets/P41594 GRM5 GPRC1E MGLUR5 P41594 Metabotropic glutamate receptor 5 dto:DTO_02100223 A metabotropic glutamate receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15303] https://pharos.nih.gov/idg/targets/O15303 GRM6 GPRC1F MGLUR6 O15303 Metabotropic glutamate receptor 6 dto:DTO_02100224 A metabotropic glutamate receptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14831] https://pharos.nih.gov/idg/targets/Q14831 GRM7 GPRC1G MGLUR7 Q14831 Metabotropic glutamate receptor 7 dto:DTO_02100225 A metabotropic glutamate receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00222] https://pharos.nih.gov/idg/targets/O00222 GRM8 GPRC1H MGLUR8 O00222 Metabotropic glutamate receptor 8 dto:DTO_02100226 A gastrin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30550] https://pharos.nih.gov/idg/targets/P30550 GRPR P30550 Gastrin-releasing peptide receptor dto:DTO_02100227 A hydroxycarboxylic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC0] https://pharos.nih.gov/idg/targets/Q9BXC0 HCAR1 GPR104 GPR81 HCA1 Q9BXC0 Hydroxycarboxylic acid receptor 1 dto:DTO_02100228 A hydroxycarboxylic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS4] https://pharos.nih.gov/idg/targets/Q8TDS4 HCAR2 GPR109A HCA2 HM74A NIACR1 Q8TDS4 Hydroxycarboxylic acid receptor 2 dto:DTO_02100229 A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49019] https://pharos.nih.gov/idg/targets/P49019 HCAR3 GPR109B HCA3 HM74B NIACR2 P49019 Hydroxycarboxylic acid receptor 3 dto:DTO_02100230 A histamine H1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35367] https://pharos.nih.gov/idg/targets/P35367 HRH1 P35367 Histamine H1 receptor dto:DTO_02100231 A histamine H2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25021] https://pharos.nih.gov/idg/targets/P25021 HRH2 P25021 Histamine h2 receptor dto:DTO_02100232 A histamine H3 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5N1] https://pharos.nih.gov/idg/targets/Q9Y5N1 HRH3 GPCR97 Q9Y5N1 Histamine H3 receptor dto:DTO_02100233 An H4 histamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H3N8] https://pharos.nih.gov/idg/targets/Q9H3N8 HRH4 GPCR105 Q9H3N8 Histamine H4 receptor dto:DTO_02100234 A KiSS-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969F8] https://pharos.nih.gov/idg/targets/Q969F8 KISS1R AXOR12 GPR54 Q969F8 Kiss-1 receptor dto:DTO_02100235 A leucine-rich repeat-containing G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXB1] https://pharos.nih.gov/idg/targets/Q9BXB1 LGR4 GPR48 Q9BXB1 Leucine-rich repeat-containing g-protein coupled receptor 4 dto:DTO_02100236 A leucine-rich repeat-containing G-protein coupled receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75473] https://pharos.nih.gov/idg/targets/O75473 LGR5 GPR49 GPR67 O75473 Leucine-rich repeat-containing G-protein coupled receptor 5 dto:DTO_02100237 A leucine-rich repeat-containing G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX8] https://pharos.nih.gov/idg/targets/Q9HBX8 LGR6 Q9HBX8 Leucine-rich repeat-containing G-protein coupled receptor 6 dto:DTO_02100238 A lysophosphatidic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92633] https://pharos.nih.gov/idg/targets/Q92633 LPAR1 EDG2 LPA1 Q92633 Lysophosphatidic acid receptor 1 dto:DTO_02100239 A lysophosphatidic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBW0] https://pharos.nih.gov/idg/targets/Q9HBW0 LPAR2 EDG4 LPA2 Q9HBW0 Lysophosphatidic acid receptor 2 dto:DTO_02100240 A lysophosphatidic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UBY5] https://pharos.nih.gov/idg/targets/Q9UBY5 LPAR3 EDG7 LPA3 Q9UBY5 Lysophosphatidic acid receptor 3 dto:DTO_02100241 A lysophosphatidic acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99677] https://pharos.nih.gov/idg/targets/Q99677 LPAR4 GPR23 LPA4 P2RY9 Q99677 Lysophosphatidic acid receptor 4 dto:DTO_02100242 A lysophosphatidic acid receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1C0] https://pharos.nih.gov/idg/targets/Q9H1C0 LPAR5 GPR92 GPR93 Q9H1C0 Lysophosphatidic acid receptor 5 dto:DTO_02100243 An oleoyl-L-alpha-lysophosphatidic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43657] https://pharos.nih.gov/idg/targets/P43657 LPAR6 P2RY5 P43657 Lysophosphatidic acid receptor 6 dto:DTO_02100244 A latrophilin-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O94910] https://pharos.nih.gov/idg/targets/O94910 LPHN1 ADGRL1 KIAA0821 LEC2 O94910 Latrophilin-1 dto:DTO_02100245 A latrophilin-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O95490] https://pharos.nih.gov/idg/targets/O95490 LPHN2 ADGRL2 KIAA0786 LEC1 LPHH1 O95490 Adhesion G protein-coupled receptor L2 dto:DTO_02100246 A latrophilin-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HAR2] https://pharos.nih.gov/idg/targets/Q9HAR2 LPHN3 ADGRL3 KIAA0768 LEC3 Q9HAR2 Latrophilin-3 dto:DTO_02100247 A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P22888] https://pharos.nih.gov/idg/targets/P22888 LHCGR LCGR LGR2 LHRHR P22888 Lutropin-choriogonadotropic hormone receptor dto:DTO_02100248 A leukotriene B4 receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15722] https://pharos.nih.gov/idg/targets/Q15722 LTB4R BLT BLT1 BLTR CMKRL1 GPR16 P2RY7 Q15722 Leukotriene b4 receptor 1 dto:DTO_02100249 A leukotriene B4 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC1] https://pharos.nih.gov/idg/targets/Q9NPC1 LTB4R2 BLT2R BLTR2 Q9NPC1 Leukotriene B4 receptor 2 dto:DTO_02100250 A mas-related G-protein coupled receptor MRG that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35410] https://pharos.nih.gov/idg/targets/P35410 MAS1L MRG P35410 Mas-related g-protein coupled receptor mrg dto:DTO_02100251 A G-protein coupled receptor MAS that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04201] https://pharos.nih.gov/idg/targets/P04201 MAS1 MAS P04201 Proto-oncogene Mas dto:DTO_02100252 A melanocortin receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41968] https://pharos.nih.gov/idg/targets/P41968 MC3R P41968 Melanocortin receptor 3 dto:DTO_02100253 A melanocortin receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32245] https://pharos.nih.gov/idg/targets/P32245 MC4R P32245 Melanocortin receptor 4 dto:DTO_02100254 A melanocortin receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P33032] https://pharos.nih.gov/idg/targets/P33032 MC5R P33032 Melanocortin receptor 5 dto:DTO_02100255 A melanin-concentrating hormone receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99705] https://pharos.nih.gov/idg/targets/Q99705 MCHR1 GPR24 SLC1 Q99705 Melanin-concentrating hormone receptor 1 dto:DTO_02100256 A melanin-concentrating hormone receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969V1] https://pharos.nih.gov/idg/targets/Q969V1 MCHR2 GPR145 SLT Q969V1 Melanin-concentrating hormone receptor 2 dto:DTO_02100257 A mas-related G-protein coupled receptor D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS7] https://pharos.nih.gov/idg/targets/Q8TDS7 MRGPRD MRGD Q8TDS7 Mas-related g-protein coupled receptor member d dto:DTO_02100258 A mas-related G-protein coupled receptor E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM8] https://pharos.nih.gov/idg/targets/Q86SM8 MRGPRE GPR167 MRGE Q86SM8 Mas-related g-protein coupled receptor member e dto:DTO_02100259 A mas-related G-protein coupled receptor F that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96AM1] https://pharos.nih.gov/idg/targets/Q96AM1 MRGPRF GPR140 GPR168 MRGF Q96AM1 Mas-related G-protein coupled receptor member F dto:DTO_02100260 A mas-related G-protein coupled receptor G that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM5] https://pharos.nih.gov/idg/targets/Q86SM5 MRGPRG GPR169 MRGG Q86SM5 Mas-related g-protein coupled receptor member g dto:DTO_02100261 A mas-related G-protein coupled receptor X1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB2] https://pharos.nih.gov/idg/targets/Q96LB2 MRGPRX1 MRGX1 SNSR3 SNSR4 Q96LB2 Mas-related g-protein coupled receptor member x1 dto:DTO_02100262 A mas-related G-protein coupled receptor X2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB1] https://pharos.nih.gov/idg/targets/Q96LB1 MRGPRX2 MRGX2 Q96LB1 Mas-related g-protein coupled receptor member x2 dto:DTO_02100263 A mas-related G-protein coupled receptor X3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB0] https://pharos.nih.gov/idg/targets/Q96LB0 MRGPRX3 MRGX3 SNSR1 SNSR2 Q96LB0 Mas-related g-protein coupled receptor member x3 dto:DTO_02100264 A mas-related G-protein coupled receptor X4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LA9] https://pharos.nih.gov/idg/targets/Q96LA9 MRGPRX4 MRGX4 SNSR5 SNSR6 Q96LA9 Mas-related G-protein coupled receptor member X4 dto:DTO_02100265 A melanocyte-stimulating hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01726] https://pharos.nih.gov/idg/targets/Q01726 MC1R MSHR Q01726 Melanocyte-stimulating hormone receptor dto:DTO_02100266 A motilin receptor that is encoded in the genome of human. [Reactome:REACT_21601] https://pharos.nih.gov/idg/targets/O43193 MLNR GPR38 MTLR MTLR1 O43193 Motilin receptor dto:DTO_02100267 A melatonin receptor type 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48039] https://pharos.nih.gov/idg/targets/P48039 MTNR1A P48039 Melatonin receptor type 1a dto:DTO_02100268 A melatonin receptor type 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49286] https://pharos.nih.gov/idg/targets/P49286 MTNR1B P49286 Melatonin receptor type 1b dto:DTO_02100269 A melatonin-related receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13585] https://pharos.nih.gov/idg/targets/Q13585 GPR50 Q13585 Melatonin-related receptor dto:DTO_02100270 A substance-P receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25103] https://pharos.nih.gov/idg/targets/P25103 TACR1 NK1R TAC1R P25103 Substance-P receptor dto:DTO_02100271 A substance-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21452] https://pharos.nih.gov/idg/targets/P21452 TACR2 NK2R NKNAR TAC2R P21452 Substance-k receptor dto:DTO_02100272 A neuromedin-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29371] https://pharos.nih.gov/idg/targets/P29371 TACR3 NK3R TAC3R P29371 Neuromedin-K receptor dto:DTO_02100273 A neuromedin-B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28336] https://pharos.nih.gov/idg/targets/P28336 NMBR P28336 Neuromedin-B receptor dto:DTO_02100274 A neuromedin-U receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB89] https://pharos.nih.gov/idg/targets/Q9HB89 NMUR1 GPR66 Q9HB89 Neuromedin-U receptor 1 dto:DTO_02100275 A neuromedin-U receptor 2 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_27011] https://pharos.nih.gov/idg/targets/Q9GZQ4 NMUR2 NMU2R TGR1 Q9GZQ4 Neuromedin-U receptor 2 dto:DTO_02100276 A neuropeptides B/W receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48145] https://pharos.nih.gov/idg/targets/P48145 NPBWR1 GPR7 P48145 Neuropeptides B/W receptor type 1 dto:DTO_02100277 A neuropeptides B/W receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48146] https://pharos.nih.gov/idg/targets/P48146 NPBWR2 GPR8 P48146 Neuropeptides b/w receptor type 2 dto:DTO_02100278 A neuropeptide FF receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZQ6] https://pharos.nih.gov/idg/targets/Q9GZQ6 NPFFR1 GPR147 NPFF1 Q9GZQ6 Neuropeptide ff receptor 1 dto:DTO_02100279 A neuropeptide FF receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5X5] https://pharos.nih.gov/idg/targets/Q9Y5X5 NPFFR2 GPR74 NPFF2 NPGPR Q9Y5X5 Neuropeptide FF receptor 2 dto:DTO_02100280 A neuropeptide S receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6W5P4] https://pharos.nih.gov/idg/targets/Q6W5P4 NPSR1 GPR154 GPRA PGR14 Q6W5P4 Neuropeptide S receptor dto:DTO_02100281 A neuropeptide Y receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25929] https://pharos.nih.gov/idg/targets/P25929 NPY1R NPYR NPYY1 P25929 Neuropeptide y receptor type 1 dto:DTO_02100282 A neuropeptide Y receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49146] https://pharos.nih.gov/idg/targets/P49146 NPY2R P49146 Neuropeptide y receptor type 2 dto:DTO_02100283 A neuropeptide Y receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50391] https://pharos.nih.gov/idg/targets/P50391 NPY4R PPYR1 P50391 Neuropeptide Y receptor type 4 dto:DTO_02100284 A neuropeptide Y receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15761] https://pharos.nih.gov/idg/targets/Q15761 NPY5R NPYR5 Q15761 Neuropeptide y receptor type 5 dto:DTO_02100286 A neurotensin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30989] https://pharos.nih.gov/idg/targets/P30989 NTSR1 NTRR P30989 Neurotensin receptor type 1 dto:DTO_02100287 A neurotensin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95665] https://pharos.nih.gov/idg/targets/O95665 NTSR2 O95665 Neurotensin receptor type 2 dto:DTO_02100288 An olfactory receptor 10A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H208] https://pharos.nih.gov/idg/targets/Q9H208 OR10A2 OR10A2P Q9H208 Olfactory receptor 10a2 dto:DTO_02100289 An olfactory receptor 10A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58181] https://pharos.nih.gov/idg/targets/P58181 OR10A3 P58181 Olfactory receptor 10A3 dto:DTO_02100290 An olfactory receptor 10A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H209] https://pharos.nih.gov/idg/targets/Q9H209 OR10A4 OR10A4P Q9H209 Olfactory receptor 10A4 dto:DTO_02100291 An olfactory receptor 10A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H207] https://pharos.nih.gov/idg/targets/Q9H207 OR10A5 OR10A1 Q9H207 Olfactory receptor 10a5 dto:DTO_02100292 An olfactory receptor 10A6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH74] https://pharos.nih.gov/idg/targets/Q8NH74 OR10A6 Q8NH74 Olfactory receptor 10a6 dto:DTO_02100293 An olfactory receptor 10A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE5] https://pharos.nih.gov/idg/targets/Q8NGE5 OR10A7 Q8NGE5 Olfactory receptor 10A7 dto:DTO_02100294 An olfactory receptor 10AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH08] https://pharos.nih.gov/idg/targets/Q8NH08 OR10AC1 OR10AC1P Q8NH08 Olfactory receptor 10AC1 dto:DTO_02100295 An olfactory receptor 10AD1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE0] https://pharos.nih.gov/idg/targets/Q8NGE0 OR10AD1 OR10AD1P Q8NGE0 Olfactory receptor 10AD1 dto:DTO_02100296 An olfactory receptor 10AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH19] https://pharos.nih.gov/idg/targets/Q8NH19 OR10AG1 Q8NH19 Olfactory receptor 10AG1 dto:DTO_02100297 An olfactory receptor 10C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KK4] https://pharos.nih.gov/idg/targets/Q96KK4 OR10C1 OR10C2 Q96KK4 Olfactory receptor 10C1 dto:DTO_02100298 An olfactory receptor 958 that is encoded in the genome of human. [OMA:HUMAN05487, PRO:DNx] https://pharos.nih.gov/idg/targets/Q8NH80 OR10D3 OR10D3P Q8NH80 Putative olfactory receptor 10d3 dto:DTO_02100299 https://pharos.nih.gov/idg/targets/Q8NGN7 OR10D4P OR10D4 Q8NGN7 Putative olfactory receptor 10d4 dto:DTO_02100300 An olfactory receptor 10G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC3] https://pharos.nih.gov/idg/targets/Q8NGC3 OR10G2 Q8NGC3 Olfactory receptor 10G2 dto:DTO_02100301 An olfactory receptor 10G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC4] https://pharos.nih.gov/idg/targets/Q8NGC4 OR10G3 Q8NGC4 Olfactory receptor 10G3 dto:DTO_02100302 An olfactory receptor 10G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN3] https://pharos.nih.gov/idg/targets/Q8NGN3 OR10G4 Q8NGN3 Olfactory receptor 10G4 dto:DTO_02100303 An olfactory receptor 10G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH81] https://pharos.nih.gov/idg/targets/Q8NH81 OR10G6 OR10G6P Q8NH81 Olfactory receptor 10G6 dto:DTO_02100304 An olfactory receptor 10G7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN6] https://pharos.nih.gov/idg/targets/Q8NGN6 OR10G7 Q8NGN6 Olfactory receptor 10G7 dto:DTO_02100305 An olfactory receptor 10G8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN5] https://pharos.nih.gov/idg/targets/Q8NGN5 OR10G8 Q8NGN5 Olfactory receptor 10G8 dto:DTO_02100306 An olfactory receptor 10G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN4] https://pharos.nih.gov/idg/targets/Q8NGN4 OR10G9 OR10G10P Q8NGN4 Olfactory receptor 10g9 dto:DTO_02100307 An olfactory receptor 10H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4A9] https://pharos.nih.gov/idg/targets/Q9Y4A9 OR10H1 Q9Y4A9 Olfactory receptor 10h1 dto:DTO_02100308 An olfactory receptor 10H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60403] https://pharos.nih.gov/idg/targets/O60403 OR10H2 O60403 Olfactory receptor 10h2 dto:DTO_02100309 An olfactory receptor 10H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60404] https://pharos.nih.gov/idg/targets/O60404 OR10H3 O60404 Olfactory receptor 10H3 dto:DTO_02100310 An olfactory receptor 10H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA5] https://pharos.nih.gov/idg/targets/Q8NGA5 OR10H4 Q8NGA5 Olfactory receptor 10H4 dto:DTO_02100311 An olfactory receptor 10H5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA6] https://pharos.nih.gov/idg/targets/Q8NGA6 OR10H5 Q8NGA6 Olfactory receptor 10h5 dto:DTO_02100312 An olfactory receptor 10J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30954] https://pharos.nih.gov/idg/targets/P30954 OR10J1 P30954 Olfactory receptor 10J1 dto:DTO_02100313 An olfactory receptor 10J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JRS4] https://pharos.nih.gov/idg/targets/Q5JRS4 OR10J3 OR10J3P Q5JRS4 Olfactory receptor 10j3 dto:DTO_02100314 An olfactory receptor 10J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C629] https://pharos.nih.gov/idg/targets/P0C629 OR10J4 OR10J4P P0C629 Olfactory receptor 10J4 dto:DTO_02100315 An olfactory receptor 10J5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC4] https://pharos.nih.gov/idg/targets/Q8NHC4 OR10J5 Q8NHC4 Olfactory receptor 10J5 dto:DTO_02100316 https://pharos.nih.gov/idg/targets/Q8NGY7 OR10J6P OR10J6 Q8NGY7 Putative olfactory receptor 10J6 dto:DTO_02100317 An olfactory receptor 10K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX5] https://pharos.nih.gov/idg/targets/Q8NGX5 OR10K1 Q8NGX5 Olfactory receptor 10K1 dto:DTO_02100318 An olfactory receptor 10K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF99] https://pharos.nih.gov/idg/targets/Q6IF99 OR10K2 Q6IF99 Olfactory receptor 10k2 dto:DTO_02100319 An olfactory receptor 10P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE3] https://pharos.nih.gov/idg/targets/Q8NGE3 OR10P1 OR10P1P OR10P2P OR10P3P Q8NGE3 Olfactory receptor 10P1 dto:DTO_02100320 An olfactory receptor 10Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ4] https://pharos.nih.gov/idg/targets/Q8NGQ4 OR10Q1 Q8NGQ4 Olfactory receptor 10q1 dto:DTO_02100321 An olfactory receptor 10R2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX6] https://pharos.nih.gov/idg/targets/Q8NGX6 OR10R2 Q8NGX6 Olfactory receptor 10r2 dto:DTO_02100322 An olfactory receptor 10S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN2] https://pharos.nih.gov/idg/targets/Q8NGN2 OR10S1 Q8NGN2 Olfactory receptor 10S1 dto:DTO_02100323 An olfactory receptor 10T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX3] https://pharos.nih.gov/idg/targets/Q8NGX3 OR10T2 Q8NGX3 Olfactory receptor 10t2 dto:DTO_02100324 An olfactory receptor 10V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI7] https://pharos.nih.gov/idg/targets/Q8NGI7 OR10V1 Q8NGI7 Olfactory receptor 10V1 dto:DTO_02100325 An olfactory receptor 10W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF6] https://pharos.nih.gov/idg/targets/Q8NGF6 OR10W1 OR10W1P Q8NGF6 Olfactory receptor 10W1 dto:DTO_02100326 An olfactory receptor 10X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY0] https://pharos.nih.gov/idg/targets/Q8NGY0 OR10X1 OR10X1P Q8NGY0 Olfactory receptor 10x1 dto:DTO_02100327 An olfactory receptor 10Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY1] https://pharos.nih.gov/idg/targets/Q8NGY1 OR10Z1 Q8NGY1 Olfactory receptor 10z1 dto:DTO_02100328 An olfactory receptor 11A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK7] https://pharos.nih.gov/idg/targets/Q9GZK7 OR11A1 OR11A2 Q9GZK7 Olfactory receptor 11A1 dto:DTO_02100329 An olfactory receptor 11G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC1] https://pharos.nih.gov/idg/targets/Q8NGC1 OR11G2 Q8NGC1 Olfactory receptor 11g2 dto:DTO_02100330 An olfactory receptor 11H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG94] https://pharos.nih.gov/idg/targets/Q8NG94 OR11H1 Q8NG94 Olfactory receptor 11h1 dto:DTO_02100331 An olfactory receptor 11H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH07] https://pharos.nih.gov/idg/targets/Q8NH07 OR11H2 C14orf15 OR11H2P Q8NH07 Olfactory receptor 11H2 dto:DTO_02100332 An olfactory receptor 11H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC9] https://pharos.nih.gov/idg/targets/Q8NGC9 OR11H4 Q8NGC9 Olfactory receptor 11H4 dto:DTO_02100333 An olfactory receptor 11H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC7] https://pharos.nih.gov/idg/targets/Q8NGC7 OR11H6 Q8NGC7 Olfactory receptor 11h6 dto:DTO_02100334 An olfactory receptor 11H7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC8] https://pharos.nih.gov/idg/targets/Q8NGC8 OR11H7 OR11H7P Q8NGC8 Olfactory receptor 11h7 dto:DTO_02100335 An olfactory receptor 11H12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:B2RN74] https://pharos.nih.gov/idg/targets/B2RN74 OR11H12 B2RN74 Olfactory receptor 11h12 dto:DTO_02100336 An olfactory receptor 11L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX0] https://pharos.nih.gov/idg/targets/Q8NGX0 OR11L1 Q8NGX0 Olfactory receptor 11L1 dto:DTO_02100337 An olfactory receptor 12D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58182] https://pharos.nih.gov/idg/targets/P58182 OR12D2 P58182 Olfactory receptor 12D2 dto:DTO_02100338 An olfactory receptor 12D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF7] https://pharos.nih.gov/idg/targets/Q9UGF7 OR12D3 Q9UGF7 Olfactory receptor 12D3 dto:DTO_02100339 An olfactory receptor 13A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR1] https://pharos.nih.gov/idg/targets/Q8NGR1 OR13A1 Q8NGR1 Olfactory receptor 13A1 dto:DTO_02100340 An olfactory receptor 13C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS9] https://pharos.nih.gov/idg/targets/Q8NGS9 OR13C2 Q8NGS9 Olfactory receptor 13C2 dto:DTO_02100341 An olfactory receptor 13C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS6] https://pharos.nih.gov/idg/targets/Q8NGS6 OR13C3 Q8NGS6 Olfactory receptor 13C3 dto:DTO_02100342 An olfactory receptor 13C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS5] https://pharos.nih.gov/idg/targets/Q8NGS5 OR13C4 Q8NGS5 Olfactory receptor 13c4 dto:DTO_02100343 An olfactory receptor 13C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS8] https://pharos.nih.gov/idg/targets/Q8NGS8 OR13C5 Q8NGS8 Olfactory receptor 13C5 dto:DTO_02100344 An olfactory receptor 13C8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS7] https://pharos.nih.gov/idg/targets/Q8NGS7 OR13C8 Q8NGS7 Olfactory receptor 13C8 dto:DTO_02100345 An olfactory receptor 13C9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT0] https://pharos.nih.gov/idg/targets/Q8NGT0 OR13C9 Q8NGT0 Olfactory receptor 13C9 dto:DTO_02100346 An olfactory receptor 13D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV5] https://pharos.nih.gov/idg/targets/Q8NGV5 OR13D1 Q8NGV5 Olfactory receptor 13d1 dto:DTO_02100347 An olfactory receptor 13F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS4] https://pharos.nih.gov/idg/targets/Q8NGS4 OR13F1 Q8NGS4 Olfactory receptor 13f1 dto:DTO_02100348 An olfactory receptor 13G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ3] https://pharos.nih.gov/idg/targets/Q8NGZ3 OR13G1 Q8NGZ3 Olfactory receptor 13G1 dto:DTO_02100349 An olfactory receptor 13H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG92] https://pharos.nih.gov/idg/targets/Q8NG92 OR13H1 Q8NG92 Olfactory receptor 13H1 dto:DTO_02100350 An olfactory receptor 13J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT2] https://pharos.nih.gov/idg/targets/Q8NGT2 OR13J1 Q8NGT2 Olfactory receptor 13J1 dto:DTO_02100351 An olfactory receptor 14A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R54] https://pharos.nih.gov/idg/targets/Q96R54 OR14A2 OR5AX1 OR5AX1P Q96R54 Olfactory receptor 14A2 dto:DTO_02100352 An olfactory receptor 14A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC5] https://pharos.nih.gov/idg/targets/Q8NHC5 OR14A16 OR5AT1 Q8NHC5 Olfactory receptor 14A16 dto:DTO_02100353 An olfactory receptor 14C36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC7] https://pharos.nih.gov/idg/targets/Q8NHC7 OR14C36 OR5BF1 Q8NHC7 Olfactory receptor 14C36 dto:DTO_02100354 An olfactory receptor 14I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6ND48] https://pharos.nih.gov/idg/targets/A6ND48 OR14I1 OR5BU1 OR5BU1P A6ND48 Olfactory receptor 14I1 dto:DTO_02100355 An olfactory receptor 14J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF5] https://pharos.nih.gov/idg/targets/Q9UGF5 OR14J1 OR5U1 Q9UGF5 Olfactory receptor 14J1 dto:DTO_02100356 An olfactory receptor 14K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ2] https://pharos.nih.gov/idg/targets/Q8NGZ2 OR14K1 OR5AY1 Q8NGZ2 Olfactory receptor 14k1 dto:DTO_02100357 https://pharos.nih.gov/idg/targets/Q8NHC6 OR14L1P OR5AV1P Q8NHC6 Putative olfactory receptor 14l1 dto:DTO_02100358 An olfactory receptor 2A12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT7] https://pharos.nih.gov/idg/targets/Q8NGT7 OR2A12 OR2A12P Q8NGT7 Olfactory receptor 2a12 dto:DTO_02100359 An olfactory receptor 2A14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R47] https://pharos.nih.gov/idg/targets/Q96R47 OR2A14 OR2A14P OR2A6 Q96R47 Olfactory receptor 2A14 dto:DTO_02100360 An olfactory receptor 2A25 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A4D2G3] https://pharos.nih.gov/idg/targets/A4D2G3 OR2A25 OR2A25P OR2A27 A4D2G3 Olfactory receptor 2A25 dto:DTO_02100361 An olfactory receptor 2AE1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA4] https://pharos.nih.gov/idg/targets/Q8NHA4 OR2AE1 OR2AE2 Q8NHA4 Olfactory receptor 2ae1 dto:DTO_02100362 An olfactory receptor 2AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H205] https://pharos.nih.gov/idg/targets/Q9H205 OR2AG1 OR2AG3 Q9H205 Olfactory receptor 2AG1 dto:DTO_02100363 An olfactory receptor 2AG2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM03] https://pharos.nih.gov/idg/targets/A6NM03 OR2AG2 OR2AG2P A6NM03 Olfactory receptor 2ag2 dto:DTO_02100364 An olfactory receptor 2AJ1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ0] https://pharos.nih.gov/idg/targets/Q8NGZ0 OR2AJ1 OR2AJ1P Q8NGZ0 Olfactory receptor 2aj1 dto:DTO_02100365 An olfactory receptor 2AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG84] https://pharos.nih.gov/idg/targets/Q8NG84 OR2AK2 OR2AK1P Q8NG84 Olfactory receptor 2AK2 dto:DTO_02100366 An olfactory receptor 2AP1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE2] https://pharos.nih.gov/idg/targets/Q8NGE2 OR2AP1 OR2AP1P Q8NGE2 Olfactory receptor 2AP1 dto:DTO_02100367 An olfactory receptor 2AT4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NND4] https://pharos.nih.gov/idg/targets/A6NND4 OR2AT4 A6NND4 Olfactory receptor 2AT4 dto:DTO_02100368 An olfactory receptor 2T10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ9] https://pharos.nih.gov/idg/targets/Q8NGZ9 OR2T10 Q8NGZ9 Olfactory receptor 2t10 dto:DTO_02100369 An olfactory receptor 2T11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH01] https://pharos.nih.gov/idg/targets/Q8NH01 OR2T11 Q8NH01 Olfactory receptor 2t11 dto:DTO_02100370 An olfactory receptor 2T12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG77] https://pharos.nih.gov/idg/targets/Q8NG77 OR2T12 Q8NG77 Olfactory receptor 2t12 dto:DTO_02100371 An olfactory receptor 2T27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH04] https://pharos.nih.gov/idg/targets/Q8NH04 OR2T27 Q8NH04 Olfactory receptor 2t27 dto:DTO_02100372 An olfactory receptor 2T29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH02] https://pharos.nih.gov/idg/targets/Q8NH02 OR2T29 Q8NH02 Olfactory receptor 2t29 dto:DTO_02100373 An olfactory receptor 2T33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG76] https://pharos.nih.gov/idg/targets/Q8NG76 OR2T33 Q8NG76 Olfactory receptor 2T33 dto:DTO_02100374 An olfactory receptor 2T34 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX1] https://pharos.nih.gov/idg/targets/Q8NGX1 OR2T34 Q8NGX1 Olfactory receptor 2t34 dto:DTO_02100375 An olfactory receptor 2T35 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX2] https://pharos.nih.gov/idg/targets/Q8NGX2 OR2T35 Q8NGX2 Olfactory receptor 2T35 dto:DTO_02100376 An olfactory receptor 4A15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL6] https://pharos.nih.gov/idg/targets/Q8NGL6 OR4A15 Q8NGL6 Olfactory receptor 4A15 dto:DTO_02100377 An olfactory receptor 4A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH70] https://pharos.nih.gov/idg/targets/Q8NH70 OR4A16 Q8NH70 Olfactory receptor 4A16 dto:DTO_02100378 An olfactory receptor 4A47 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF82] https://pharos.nih.gov/idg/targets/Q6IF82 OR4A47 Q6IF82 Olfactory receptor 4a47 dto:DTO_02100379 An olfactory receptor 4C45 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMZ5] https://pharos.nih.gov/idg/targets/A6NMZ5 OR4C45 A6NMZ5 Olfactory receptor 4c45 dto:DTO_02100380 An olfactory receptor 4C46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHA9] https://pharos.nih.gov/idg/targets/A6NHA9 OR4C46 A6NHA9 Olfactory receptor 4C46 dto:DTO_02100381 An olfactory receptor 4F15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB8] https://pharos.nih.gov/idg/targets/Q8NGB8 OR4F15 Q8NGB8 Olfactory receptor 4f15 dto:DTO_02100382 An olfactory receptor 4F17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA8] https://pharos.nih.gov/idg/targets/Q8NGA8 OR4F17 OR4F11P OR4F18 OR4F19 Q8NGA8 Olfactory receptor 4f17 dto:DTO_02100383 An olfactory receptor 4F21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95013] https://pharos.nih.gov/idg/targets/O95013 OR4F21 OR4F21P O95013 Olfactory receptor 4F21 dto:DTO_02100384 An olfactory receptor 51A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ7] https://pharos.nih.gov/idg/targets/Q8NGJ7 OR51A2 Q8NGJ7 Olfactory receptor 51A2 dto:DTO_02100385 An olfactory receptor 51A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ6] https://pharos.nih.gov/idg/targets/Q8NGJ6 OR51A4 Q8NGJ6 Olfactory receptor 51A4 dto:DTO_02100386 An olfactory receptor 51A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH64] https://pharos.nih.gov/idg/targets/Q8NH64 OR51A7 Q8NH64 Olfactory receptor 51a7 dto:DTO_02100387 An olfactory receptor 51B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P1] https://pharos.nih.gov/idg/targets/Q9Y5P1 OR51B2 OR51B1P Q9Y5P1 Olfactory receptor 51b2 dto:DTO_02100388 An olfactory receptor 51B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P0] https://pharos.nih.gov/idg/targets/Q9Y5P0 OR51B4 Q9Y5P0 Olfactory receptor 51B4 dto:DTO_02100389 An olfactory receptor 51B5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H339] https://pharos.nih.gov/idg/targets/Q9H339 OR51B5 Q9H339 Olfactory receptor 51B5 dto:DTO_02100390 An olfactory receptor 51B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H340] https://pharos.nih.gov/idg/targets/Q9H340 OR51B6 Q9H340 Olfactory receptor 51B6 dto:DTO_02100391 An olfactory receptor 51D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF3] https://pharos.nih.gov/idg/targets/Q8NGF3 OR51D1 Q8NGF3 Olfactory receptor 51D1 dto:DTO_02100392 An olfactory receptor 51E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCB6] https://pharos.nih.gov/idg/targets/Q8TCB6 OR51E1 GPR164 OR51E1P OR52A3P POGR PSGR2 Q8TCB6 Olfactory receptor 51e1 dto:DTO_02100393 An olfactory receptor 51E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H255] https://pharos.nih.gov/idg/targets/Q9H255 OR51E2 PSGR Q9H255 Olfactory receptor 51e2 dto:DTO_02100394 An olfactory receptor 51F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NGY5] https://pharos.nih.gov/idg/targets/A6NGY5 OR51F1 OR51F1P A6NGY5 Olfactory receptor 51f1 dto:DTO_02100395 An olfactory receptor 51F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH61] https://pharos.nih.gov/idg/targets/Q8NH61 OR51F2 Q8NH61 Olfactory receptor 51F2 dto:DTO_02100396 An olfactory receptor 51G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK1] https://pharos.nih.gov/idg/targets/Q8NGK1 OR51G1 OR51G3P Q8NGK1 Olfactory receptor 51g1 dto:DTO_02100397 An olfactory receptor 51G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK0] https://pharos.nih.gov/idg/targets/Q8NGK0 OR51G2 Q8NGK0 Olfactory receptor 51g2 dto:DTO_02100398 https://pharos.nih.gov/idg/targets/Q8NH63 OR51H1P OR51H1 Q8NH63 Olfactory receptor 51H1 dto:DTO_02100399 An olfactory receptor 51I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H343] https://pharos.nih.gov/idg/targets/Q9H343 OR51I1 Q9H343 Olfactory receptor 51I1 dto:DTO_02100400 An olfactory receptor 51I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H344] https://pharos.nih.gov/idg/targets/Q9H344 OR51I2 Q9H344 Olfactory receptor 51I2 dto:DTO_02100401 An olfactory receptor 51J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H342] https://pharos.nih.gov/idg/targets/Q9H342 OR51J1 OR51J1P OR51J2 Q9H342 Olfactory receptor 51J1 dto:DTO_02100402 An olfactory receptor 51L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ5] https://pharos.nih.gov/idg/targets/Q8NGJ5 OR51L1 Q8NGJ5 Olfactory receptor 51l1 dto:DTO_02100403 An olfactory receptor 51M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H341] https://pharos.nih.gov/idg/targets/Q9H341 OR51M1 Q9H341 Olfactory receptor 51m1 dto:DTO_02100404 An olfactory receptor 51Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH59] https://pharos.nih.gov/idg/targets/Q8NH59 OR51Q1 Q8NH59 Olfactory receptor 51Q1 dto:DTO_02100405 An olfactory receptor 51S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ8] https://pharos.nih.gov/idg/targets/Q8NGJ8 OR51S1 Q8NGJ8 Olfactory receptor 51S1 dto:DTO_02100406 An olfactory receptor 51T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ9] https://pharos.nih.gov/idg/targets/Q8NGJ9 OR51T1 Q8NGJ9 Olfactory receptor 51T1 dto:DTO_02100407 An olfactory receptor 51V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C8] https://pharos.nih.gov/idg/targets/Q9H2C8 OR51V1 OR51A12 Q9H2C8 Olfactory receptor 51V1 dto:DTO_02100408 An olfactory receptor 52A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKL2] https://pharos.nih.gov/idg/targets/Q9UKL2 OR52A1 Q9UKL2 Olfactory receptor 52a1 dto:DTO_02100409 https://pharos.nih.gov/idg/targets/A6NMU1 OR52A4 OR52A4P A6NMU1 Olfactory receptor 52A4 dto:DTO_02100410 An olfactory receptor 52A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C5] https://pharos.nih.gov/idg/targets/Q9H2C5 OR52A5 Q9H2C5 Olfactory receptor 52a5 dto:DTO_02100411 An olfactory receptor 52B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD2] https://pharos.nih.gov/idg/targets/Q96RD2 OR52B2 Q96RD2 Olfactory receptor 52B2 dto:DTO_02100412 An olfactory receptor 52B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK2] https://pharos.nih.gov/idg/targets/Q8NGK2 OR52B4 Q8NGK2 Olfactory receptor 52B4 dto:DTO_02100413 An olfactory receptor 52B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF0] https://pharos.nih.gov/idg/targets/Q8NGF0 OR52B6 Q8NGF0 Olfactory receptor 52B6 dto:DTO_02100414 An olfactory receptor 52D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H346] https://pharos.nih.gov/idg/targets/Q9H346 OR52D1 Q9H346 Olfactory receptor 52D1 dto:DTO_02100415 An olfactory receptor 52E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ3] https://pharos.nih.gov/idg/targets/Q8NGJ3 OR52E1 OR52E1P Q8NGJ3 Olfactory receptor 52E1 dto:DTO_02100416 An olfactory receptor 52E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ4] https://pharos.nih.gov/idg/targets/Q8NGJ4 OR52E2 Q8NGJ4 Olfactory receptor 52E2 dto:DTO_02100417 An olfactory receptor 52E4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH9] https://pharos.nih.gov/idg/targets/Q8NGH9 OR52E4 Q8NGH9 Olfactory receptor 52E4 dto:DTO_02100418 An olfactory receptor 52E5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH55] https://pharos.nih.gov/idg/targets/Q8NH55 OR52E5 Q8NH55 Olfactory receptor 52E5 dto:DTO_02100419 An olfactory receptor 52E6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD3] https://pharos.nih.gov/idg/targets/Q96RD3 OR52E6 Q96RD3 Olfactory receptor 52E6 dto:DTO_02100420 An olfactory receptor 52E8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFG1] https://pharos.nih.gov/idg/targets/Q6IFG1 OR52E8 Q6IFG1 Olfactory receptor 52E8 dto:DTO_02100421 An olfactory receptor 52H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ2] https://pharos.nih.gov/idg/targets/Q8NGJ2 OR52H1 Q8NGJ2 Olfactory receptor 52h1 dto:DTO_02100422 An olfactory receptor 52I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK6] https://pharos.nih.gov/idg/targets/Q8NGK6 OR52I1 Q8NGK6 Olfactory receptor 52i1 dto:DTO_02100423 An olfactory receptor 52I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH67] https://pharos.nih.gov/idg/targets/Q8NH67 OR52I2 Q8NH67 Olfactory receptor 52I2 dto:DTO_02100424 An olfactory receptor 52J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH60] https://pharos.nih.gov/idg/targets/Q8NH60 OR52J3 Q8NH60 Olfactory receptor 52J3 dto:DTO_02100425 An olfactory receptor 52K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK4] https://pharos.nih.gov/idg/targets/Q8NGK4 OR52K1 Q8NGK4 Olfactory receptor 52k1 dto:DTO_02100426 An olfactory receptor 52K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK3] https://pharos.nih.gov/idg/targets/Q8NGK3 OR52K2 Q8NGK3 Olfactory receptor 52k2 dto:DTO_02100427 An olfactory receptor 52L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH7] https://pharos.nih.gov/idg/targets/Q8NGH7 OR52L1 Q8NGH7 Olfactory receptor 52l1 dto:DTO_02100428 https://pharos.nih.gov/idg/targets/Q8NGH6 OR52L2P OR52L2 Q8NGH6 Putative olfactory receptor 52l2 dto:DTO_02100429 An olfactory receptor 52M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK5] https://pharos.nih.gov/idg/targets/Q8NGK5 OR52M1 OR52M1P Q8NGK5 Olfactory receptor 52M1 dto:DTO_02100430 An olfactory receptor 52N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH53] https://pharos.nih.gov/idg/targets/Q8NH53 OR52N1 Q8NH53 Olfactory receptor 52n1 dto:DTO_02100431 An olfactory receptor 52N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI0] https://pharos.nih.gov/idg/targets/Q8NGI0 OR52N2 Q8NGI0 Olfactory receptor 52n2 dto:DTO_02100432 An olfactory receptor 52N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI2] https://pharos.nih.gov/idg/targets/Q8NGI2 OR52N4 Q8NGI2 Olfactory receptor 52n4 dto:DTO_02100433 An olfactory receptor 52N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH56] https://pharos.nih.gov/idg/targets/Q8NH56 OR52N5 Q8NH56 Olfactory receptor 52n5 dto:DTO_02100434 https://pharos.nih.gov/idg/targets/Q8NH57 OR52P1P OR52P1 Q8NH57 Putative olfactory receptor 52p1 dto:DTO_02100435 An olfactory receptor 52R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF1] https://pharos.nih.gov/idg/targets/Q8NGF1 OR52R1 Q8NGF1 Olfactory receptor 52R1 dto:DTO_02100436 An olfactory receptor 52W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF63] https://pharos.nih.gov/idg/targets/Q6IF63 OR52W1 OR52W1P Q6IF63 Olfactory receptor 52W1 dto:DTO_02100437 An olfactory receptor 52Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C646] https://pharos.nih.gov/idg/targets/P0C646 OR52Z1 OR52Z1P P0C646 Olfactory receptor 52z1 dto:DTO_02100438 An olfactory receptor 56A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH5] https://pharos.nih.gov/idg/targets/Q8NGH5 OR56A1 Q8NGH5 Olfactory receptor 56a1 dto:DTO_02100439 An olfactory receptor 56A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH54] https://pharos.nih.gov/idg/targets/Q8NH54 OR56A3 OR56A3P OR56A6 Q8NH54 Olfactory receptor 56A3 dto:DTO_02100440 An olfactory receptor 56A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH8] https://pharos.nih.gov/idg/targets/Q8NGH8 OR56A4 Q8NGH8 Olfactory receptor 56a4 dto:DTO_02100441 An olfactory receptor 56A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T3] https://pharos.nih.gov/idg/targets/P0C7T3 OR56A5 OR56A5P P0C7T3 Olfactory receptor 56a5 dto:DTO_02100442 An olfactory receptor 56B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI3] https://pharos.nih.gov/idg/targets/Q8NGI3 OR56B1 OR56B1P Q8NGI3 Olfactory receptor 56B1 dto:DTO_02100443 https://pharos.nih.gov/idg/targets/Q8NGI1 OR56B2P Q8NGI1 Putative olfactory receptor 56b2 dto:DTO_02100444 An olfactory receptor 56B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH76] https://pharos.nih.gov/idg/targets/Q8NH76 OR56B4 Q8NH76 Olfactory receptor 56b4 dto:DTO_02100445 An olfactory receptor 5AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C628] https://pharos.nih.gov/idg/targets/P0C628 OR5AC1 OR5AC1P P0C628 Olfactory receptor 5ac1 dto:DTO_02100446 An olfactory receptor 5AC2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP5] https://pharos.nih.gov/idg/targets/Q9NZP5 OR5AC2 Q9NZP5 Olfactory receptor 5AC2 dto:DTO_02100447 An olfactory receptor 5AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH90] https://pharos.nih.gov/idg/targets/Q8NH90 OR5AK2 Q8NH90 Olfactory receptor 5ak2 dto:DTO_02100448 https://pharos.nih.gov/idg/targets/Q8NH89 OR5AK3P OR5AK3 Q8NH89 Putative olfactory receptor 5AK3 dto:DTO_02100449 An olfactory receptor 5AL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C617] https://pharos.nih.gov/idg/targets/P0C617 OR5AL1 OR5AL1P P0C617 Olfactory receptor 5al1 dto:DTO_02100450 An olfactory receptor 5AN1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI8] https://pharos.nih.gov/idg/targets/Q8NGI8 OR5AN1 Q8NGI8 Olfactory receptor 5AN1 dto:DTO_02100451 An olfactory receptor 5AP2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF4] https://pharos.nih.gov/idg/targets/Q8NGF4 OR5AP2 Q8NGF4 Olfactory receptor 5AP2 dto:DTO_02100452 An olfactory receptor 5AR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP9] https://pharos.nih.gov/idg/targets/Q8NGP9 OR5AR1 Q8NGP9 Olfactory receptor 5AR1 dto:DTO_02100453 An olfactory receptor 5AS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N127] https://pharos.nih.gov/idg/targets/Q8N127 OR5AS1 Q8N127 Olfactory receptor 5as1 dto:DTO_02100454 An olfactory receptor 5AU1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC0] https://pharos.nih.gov/idg/targets/Q8NGC0 OR5AU1 Q8NGC0 Olfactory receptor 5au1 dto:DTO_02100455 An olfactory receptor 5H14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHG9] https://pharos.nih.gov/idg/targets/A6NHG9 OR5H14 A6NHG9 Olfactory receptor 5h14 dto:DTO_02100456 An olfactory receptor 5H15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDH6] https://pharos.nih.gov/idg/targets/A6NDH6 OR5H15 A6NDH6 Olfactory receptor 5H15 dto:DTO_02100457 An olfactory receptor 6C65 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NJZ3] https://pharos.nih.gov/idg/targets/A6NJZ3 OR6C65 A6NJZ3 Olfactory receptor 6c65 dto:DTO_02100458 An olfactory receptor 6C68 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDL8] https://pharos.nih.gov/idg/targets/A6NDL8 OR6C68 A6NDL8 Olfactory receptor 6c68 dto:DTO_02100459 An olfactory receptor 6C70 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NIJ9] https://pharos.nih.gov/idg/targets/A6NIJ9 OR6C70 A6NIJ9 Olfactory receptor 6c70 dto:DTO_02100460 An olfactory receptor 6C74 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NCV1] https://pharos.nih.gov/idg/targets/A6NCV1 OR6C74 A6NCV1 Olfactory receptor 6C74 dto:DTO_02100461 An olfactory receptor 6C75 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL08] https://pharos.nih.gov/idg/targets/A6NL08 OR6C75 A6NL08 Olfactory receptor 6C75 dto:DTO_02100462 An olfactory receptor 6C76 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM76] https://pharos.nih.gov/idg/targets/A6NM76 OR6C76 A6NM76 Olfactory receptor 6c76 dto:DTO_02100463 An olfactory receptor 7E24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFN5] https://pharos.nih.gov/idg/targets/Q6IFN5 OR7E24 OR7E24P Q6IFN5 Olfactory receptor 7E24 dto:DTO_02100464 A sphingosylphosphorylcholine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15743] https://pharos.nih.gov/idg/targets/Q15743 GPR68 OGR1 Q15743 Ovarian cancer G-protein coupled receptor 1 dto:DTO_02100465 An encephalopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1Y3] https://pharos.nih.gov/idg/targets/Q9H1Y3 OPN3 ECPN Q9H1Y3 Opsin-3 dto:DTO_02100466 A melanopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UHM6] https://pharos.nih.gov/idg/targets/Q9UHM6 OPN4 MOP Q9UHM6 Melanopsin dto:DTO_02100467 An opsin-5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6U736] https://pharos.nih.gov/idg/targets/Q6U736 OPN5 GPR136 PGR12 TMEM13 Q6U736 Opsin-5 dto:DTO_02100468 A delta-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41143] https://pharos.nih.gov/idg/targets/P41143 OPRD1 OPRD P41143 Delta-type opioid receptor dto:DTO_02100469 A kappa-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41145] https://pharos.nih.gov/idg/targets/P41145 OPRK1 OPRK P41145 Kappa-type opioid receptor dto:DTO_02100470 A mu-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35372] https://pharos.nih.gov/idg/targets/P35372 OPRM1 MOR1 P35372 Mu-type opioid receptor dto:DTO_02100471 A nociceptin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41146] https://pharos.nih.gov/idg/targets/P41146 OPRL1 OOR ORL1 P41146 Nociceptin receptor dto:DTO_02100472 A short-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P03999] https://pharos.nih.gov/idg/targets/P03999 OPN1SW BCP P03999 Short-wave-sensitive opsin 1 dto:DTO_02100473 A rhodopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08100] https://pharos.nih.gov/idg/targets/P08100 RHO OPN2 P08100 Rhodopsin dto:DTO_02100474 A medium-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB] https://pharos.nih.gov/idg/targets/P04001 OPN1MW GCP OPN1MW2 P04001 Medium-wave-sensitive opsin 1 dto:DTO_02100475 A long-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04000] https://pharos.nih.gov/idg/targets/P04000 OPN1LW RCP P04000 Long-wave-sensitive opsin 1 dto:DTO_02100476 A visual pigment-like receptor peropsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14718] https://pharos.nih.gov/idg/targets/O14718 RRH O14718 Visual pigment-like receptor peropsin dto:DTO_02100477 An olfactory receptor 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P1Q5] https://pharos.nih.gov/idg/targets/Q9P1Q5 OR1A1 Q9P1Q5 Olfactory receptor 1A1 dto:DTO_02100478 An olfactory receptor 1A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y585] https://pharos.nih.gov/idg/targets/Q9Y585 OR1A2 Q9Y585 Olfactory receptor 1A2 dto:DTO_02100479 An olfactory receptor 1B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR6] https://pharos.nih.gov/idg/targets/Q8NGR6 OR1B1 Q8NGR6 Olfactory receptor 1B1 dto:DTO_02100480 An olfactory receptor 1C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15619] https://pharos.nih.gov/idg/targets/Q15619 OR1C1 Q15619 Olfactory receptor 1C1 dto:DTO_02100481 An olfactory receptor 1D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34982] https://pharos.nih.gov/idg/targets/P34982 OR1D2 OLFR1 P34982 Olfactory receptor 1D2 dto:DTO_02100482 An olfactory receptor 1D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47884] https://pharos.nih.gov/idg/targets/P47884 OR1D4 P47884 Olfactory receptor 1D4 dto:DTO_02100483 An olfactory receptor 1D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58170] https://pharos.nih.gov/idg/targets/P58170 OR1D5 P58170 Olfactory receptor 1D5 dto:DTO_02100484 An olfactory receptor 1E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30953] https://pharos.nih.gov/idg/targets/P30953 OR1E1 OR1E5 OR1E6 OR1E9P P30953 Olfactory receptor 1E1 dto:DTO_02100485 An olfactory receptor 1E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47887] https://pharos.nih.gov/idg/targets/P47887 OR1E2 OR1E4 P47887 Olfactory receptor 1e2 dto:DTO_02100486 An olfactory receptor 1E3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZA6] https://pharos.nih.gov/idg/targets/Q8WZA6 OR1E3 OR1E3P Q8WZA6 Olfactory receptor 1e3 dto:DTO_02100487 An olfactory receptor 1F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43749] https://pharos.nih.gov/idg/targets/O43749 OR1F1 OLFMF OR1F10 OR1F4 OR1F5 OR1F6 OR1F7 OR1F8 OR1F9 O43749 Olfactory receptor 1f1 dto:DTO_02100488 An olfactory receptor 1F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R84] https://pharos.nih.gov/idg/targets/Q96R84 OR1F2P OR1F2 Q96R84 Putative olfactory receptor 1f2 dto:DTO_02100489 An olfactory receptor 1F12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA8] https://pharos.nih.gov/idg/targets/Q8NHA8 OR1F12 OR1F12P Q8NHA8 Olfactory receptor 1F12 dto:DTO_02100490 An olfactory receptor 1G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47890] https://pharos.nih.gov/idg/targets/P47890 OR1G1 OR1G2 P47890 Olfactory receptor 1G1 dto:DTO_02100491 An olfactory receptor 1I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60431] https://pharos.nih.gov/idg/targets/O60431 OR1I1 O60431 Olfactory receptor 1I1 dto:DTO_02100492 An olfactory receptor 1J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS3] https://pharos.nih.gov/idg/targets/Q8NGS3 OR1J1 Q8NGS3 Olfactory receptor 1J1 dto:DTO_02100493 An olfactory receptor 1J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS2] https://pharos.nih.gov/idg/targets/Q8NGS2 OR1J2 OR1J3 OR1J5 Q8NGS2 Olfactory receptor 1J2 dto:DTO_02100494 An olfactory receptor 1J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS1] https://pharos.nih.gov/idg/targets/Q8NGS1 OR1J4 Q8NGS1 Olfactory receptor 1J4 dto:DTO_02100495 An olfactory receptor 1K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR3] https://pharos.nih.gov/idg/targets/Q8NGR3 OR1K1 Q8NGR3 Olfactory receptor 1K1 dto:DTO_02100496 An olfactory receptor 1L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH94] https://pharos.nih.gov/idg/targets/Q8NH94 OR1L1 OR1L2 Q8NH94 Olfactory receptor 1L1 dto:DTO_02100497 An olfactory receptor 1L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH93] https://pharos.nih.gov/idg/targets/Q8NH93 OR1L3 Q8NH93 Olfactory receptor 1l3 dto:DTO_02100498 An olfactory receptor 1L4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR5] https://pharos.nih.gov/idg/targets/Q8NGR5 OR1L4 OR1L5 Q8NGR5 Olfactory receptor 1l4 dto:DTO_02100499 An olfactory receptor 1L6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR2] https://pharos.nih.gov/idg/targets/Q8NGR2 OR1L6 OR1L7 Q8NGR2 Olfactory receptor 1l6 dto:DTO_02100500 An olfactory receptor 1L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR8] https://pharos.nih.gov/idg/targets/Q8NGR8 OR1L8 Q8NGR8 Olfactory receptor 1L8 dto:DTO_02100501 An olfactory receptor 1M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA1] https://pharos.nih.gov/idg/targets/Q8NGA1 OR1M1 Q8NGA1 Olfactory receptor 1m1 dto:DTO_02100502 An olfactory receptor 1N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS0] https://pharos.nih.gov/idg/targets/Q8NGS0 OR1N1 OR1N3 Q8NGS0 Olfactory receptor 1N1 dto:DTO_02100503 An olfactory receptor 1N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR9] https://pharos.nih.gov/idg/targets/Q8NGR9 OR1N2 Q8NGR9 Olfactory receptor 1n2 dto:DTO_02100504 An olfactory receptor 1P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH06] https://pharos.nih.gov/idg/targets/Q8NH06 OR1P1 OR1P1P Q8NH06 Olfactory receptor 1p1 dto:DTO_02100505 An olfactory receptor 1Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15612] https://pharos.nih.gov/idg/targets/Q15612 OR1Q1 OR1Q2 OR1Q3 Q15612 Olfactory receptor 1Q1 dto:DTO_02100506 An olfactory receptor 1S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH92] https://pharos.nih.gov/idg/targets/Q8NH92 OR1S1 Q8NH92 Olfactory receptor 1S1 dto:DTO_02100507 An olfactory receptor 1S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ3] https://pharos.nih.gov/idg/targets/Q8NGQ3 OR1S2 Q8NGQ3 Olfactory receptor 1s2 dto:DTO_02100508 An olfactory receptor 2A1/2A42 that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q8NGT9 OR2A1 OR2A42 Q8NGT9 Olfactory receptor 2A1/2A42 dto:DTO_02100509 An olfactory receptor 2A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF42] https://pharos.nih.gov/idg/targets/Q6IF42 OR2A2 OR2A17P OR2A2P Q6IF42 Olfactory receptor 2A2 dto:DTO_02100510 An olfactory receptor 2A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95047] https://pharos.nih.gov/idg/targets/O95047 OR2A4 OR2A10 O95047 Olfactory receptor 2a4 dto:DTO_02100511 An olfactory receptor 2A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R48] https://pharos.nih.gov/idg/targets/Q96R48 OR2A5 OR2A26 OR2A8 Q96R48 Olfactory receptor 2a5 dto:DTO_02100512 An olfactory receptor 2A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R45] https://pharos.nih.gov/idg/targets/Q96R45 OR2A7 Q96R45 Olfactory receptor 2a7 dto:DTO_02100513 An olfactory receptor 2B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK3] https://pharos.nih.gov/idg/targets/Q9GZK3 OR2B2 OR2B9 Q9GZK3 Olfactory receptor 2B2 dto:DTO_02100514 An olfactory receptor 2B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76000] https://pharos.nih.gov/idg/targets/O76000 OR2B3 OR2B3P O76000 Putative olfactory receptor 2B3 dto:DTO_02100515 An olfactory receptor 2B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58173] https://pharos.nih.gov/idg/targets/P58173 OR2B6 OR2B1 OR2B1P OR2B5 OR2B6P P58173 Olfactory receptor 2B6 dto:DTO_02100516 https://pharos.nih.gov/idg/targets/P59922 OR2B8P OR2B8 P59922 Putative olfactory receptor 2B8 dto:DTO_02100517 An olfactory receptor 2B11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JQS5] https://pharos.nih.gov/idg/targets/Q5JQS5 OR2B11 Q5JQS5 Olfactory receptor 2B11 dto:DTO_02100518 An olfactory receptor 2C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95371] https://pharos.nih.gov/idg/targets/O95371 OR2C1 OR2C2P O95371 Olfactory receptor 2C1 dto:DTO_02100519 An olfactory receptor 2C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N628] https://pharos.nih.gov/idg/targets/Q8N628 OR2C3 OR2C4 OR2C5P Q8N628 Olfactory receptor 2C3 dto:DTO_02100520 An olfactory receptor 2D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H210] https://pharos.nih.gov/idg/targets/Q9H210 OR2D2 OR2D1 Q9H210 Olfactory receptor 2d2 dto:DTO_02100521 An olfactory receptor 2D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH3] https://pharos.nih.gov/idg/targets/Q8NGH3 OR2D3 Q8NGH3 Olfactory receptor 2D3 dto:DTO_02100522 An olfactory receptor 2F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13607] https://pharos.nih.gov/idg/targets/Q13607 OR2F1 OLF3 OR2F3 OR2F3P OR2F4 OR2F5 Q13607 Olfactory receptor 2F1 dto:DTO_02100523 An olfactory receptor 2F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95006] https://pharos.nih.gov/idg/targets/O95006 OR2F2 O95006 Olfactory receptor 2f2 dto:DTO_02100524 An olfactory receptor 2G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ5] https://pharos.nih.gov/idg/targets/Q8NGZ5 OR2G2 Q8NGZ5 Olfactory receptor 2G2 dto:DTO_02100525 An olfactory receptor 2G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ4] https://pharos.nih.gov/idg/targets/Q8NGZ4 OR2G3 Q8NGZ4 Olfactory receptor 2g3 dto:DTO_02100526 An olfactory receptor 2G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TZ20] https://pharos.nih.gov/idg/targets/Q5TZ20 OR2G6 Q5TZ20 Olfactory receptor 2g6 dto:DTO_02100527 An olfactory receptor 2H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK4] https://pharos.nih.gov/idg/targets/Q9GZK4 OR2H1 OR2H6 OR2H8 Q9GZK4 Olfactory receptor 2H1 dto:DTO_02100528 An olfactory receptor 2H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95918] https://pharos.nih.gov/idg/targets/O95918 OR2H2 FAT11 OLFR2 OR2H3 O95918 Olfactory receptor 2H2 dto:DTO_02100529 https://pharos.nih.gov/idg/targets/Q8NGU4 OR2I1P OR2I2 OR2I3P OR2I4P Q8NGU4 Putative olfactory receptor 2I1 dto:DTO_02100530 An olfactory receptor 2J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK6] https://pharos.nih.gov/idg/targets/Q9GZK6 OR2J1 OR2J1P Q9GZK6 Olfactory receptor 2J1 dto:DTO_02100531 An olfactory receptor 2J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76002] https://pharos.nih.gov/idg/targets/O76002 OR2J2 O76002 Olfactory receptor 2J2 dto:DTO_02100532 An olfactory receptor 2J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76001] https://pharos.nih.gov/idg/targets/O76001 OR2J3 O76001 Olfactory receptor 2J3 dto:DTO_02100533 An olfactory receptor 2K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT1] https://pharos.nih.gov/idg/targets/Q8NGT1 OR2K2 OR2AR1P Q8NGT1 Olfactory receptor 2k2 dto:DTO_02100534 An olfactory receptor 2L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH16] https://pharos.nih.gov/idg/targets/Q8NH16 OR2L2 OR2L12 OR2L4P Q8NH16 Olfactory receptor 2l2 dto:DTO_02100535 An olfactory receptor 2L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG85] https://pharos.nih.gov/idg/targets/Q8NG85 OR2L3 Q8NG85 Olfactory receptor 2L3 dto:DTO_02100536 An olfactory receptor 2L5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG80] https://pharos.nih.gov/idg/targets/Q8NG80 OR2L5 OR2L11 Q8NG80 Olfactory receptor 2L5 dto:DTO_02100537 An olfactory receptor 2L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY9] https://pharos.nih.gov/idg/targets/Q8NGY9 OR2L8 Q8NGY9 Olfactory receptor 2l8 dto:DTO_02100538 An olfactory receptor 2L13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N349] https://pharos.nih.gov/idg/targets/Q8N349 OR2L13 OR2L14 Q8N349 Olfactory receptor 2L13 dto:DTO_02100539 An olfactory receptor 2M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R28] https://pharos.nih.gov/idg/targets/Q96R28 OR2M2 Q96R28 Olfactory receptor 2m2 dto:DTO_02100540 An olfactory receptor 2M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG83] https://pharos.nih.gov/idg/targets/Q8NG83 OR2M3 OR2M3P OR2M6 Q8NG83 Olfactory receptor 2m3 dto:DTO_02100541 An olfactory receptor 2M4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R27] https://pharos.nih.gov/idg/targets/Q96R27 OR2M4 Q96R27 Olfactory receptor 2m4 dto:DTO_02100542 An olfactory receptor 2M5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A3KFT3] https://pharos.nih.gov/idg/targets/A3KFT3 OR2M5 OR2M5P A3KFT3 Olfactory receptor 2M5 dto:DTO_02100543 An olfactory receptor 2M7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG81] https://pharos.nih.gov/idg/targets/Q8NG81 OR2M7 Q8NG81 Olfactory receptor 2M7 dto:DTO_02100544 An olfactory receptor 2S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQN1] https://pharos.nih.gov/idg/targets/Q9NQN1 OR2S2 Q9NQN1 Olfactory receptor 2s2 dto:DTO_02100545 An olfactory receptor 2T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43869] https://pharos.nih.gov/idg/targets/O43869 OR2T1 O43869 Olfactory receptor 2T1 dto:DTO_02100546 An olfactory receptor 2T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF00] https://pharos.nih.gov/idg/targets/Q6IF00 OR2T2 OR2T2P Q6IF00 Olfactory receptor 2T2 dto:DTO_02100547 An olfactory receptor 2T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH03] https://pharos.nih.gov/idg/targets/Q8NH03 OR2T3 Q8NH03 Olfactory receptor 2T3 dto:DTO_02100548 An olfactory receptor 2T4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH00] https://pharos.nih.gov/idg/targets/Q8NH00 OR2T4 Q8NH00 Olfactory receptor 2T4 dto:DTO_02100549 An olfactory receptor 2T5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEZ7] https://pharos.nih.gov/idg/targets/Q6IEZ7 OR2T5 Q6IEZ7 Olfactory receptor 2t5 dto:DTO_02100550 An olfactory receptor 2T6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC8] https://pharos.nih.gov/idg/targets/Q8NHC8 OR2T6 OR2T6P OR2T9 Q8NHC8 Olfactory receptor 2t6 dto:DTO_02100551 An olfactory receptor 2T7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T2] https://pharos.nih.gov/idg/targets/P0C7T2 OR2T7 OR2T7P P0C7T2 Olfactory receptor 2T7 dto:DTO_02100552 An olfactory receptor 2T8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NH00] https://pharos.nih.gov/idg/targets/A6NH00 OR2T8 OR2T8P A6NH00 Olfactory receptor 2t8 dto:DTO_02100553 An olfactory receptor 2V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB1] https://pharos.nih.gov/idg/targets/Q8NHB1 OR2V1 Q8NHB1 Olfactory receptor 2V1 dto:DTO_02100554 An olfactory receptor 2V2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R30] https://pharos.nih.gov/idg/targets/Q96R30 OR2V2 OR2V3 Q96R30 Olfactory receptor 2v2 dto:DTO_02100555 An olfactory receptor 2W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3N9] https://pharos.nih.gov/idg/targets/Q9Y3N9 OR2W1 Q9Y3N9 Olfactory receptor 2w1 dto:DTO_02100556 An olfactory receptor 2W3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3T1] https://pharos.nih.gov/idg/targets/Q7Z3T1 OR2W3 OR2W3P OR2W8P Q7Z3T1 Olfactory receptor 2W3 dto:DTO_02100557 https://pharos.nih.gov/idg/targets/A6NFC9 OR2W5 OR2W5P A6NFC9 Putative olfactory receptor 2w5 dto:DTO_02100558 https://pharos.nih.gov/idg/targets/Q8NHA6 OR2W6P OR2W7P Q8NHA6 Putative olfactory receptor 2w6 dto:DTO_02100559 An olfactory receptor 2Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV0] https://pharos.nih.gov/idg/targets/Q8NGV0 OR2Y1 Q8NGV0 Olfactory receptor 2Y1 dto:DTO_02100560 An olfactory receptor 2Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG97] https://pharos.nih.gov/idg/targets/Q8NG97 OR2Z1 OR2Z2 Q8NG97 Olfactory receptor 2Z1 dto:DTO_02100561 An olfactory receptor 3A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47881] https://pharos.nih.gov/idg/targets/P47881 OR3A1 OLFRA03 P47881 Olfactory receptor 3A1 dto:DTO_02100562 An olfactory receptor 3A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47893] https://pharos.nih.gov/idg/targets/P47893 OR3A2 OLFRA04 P47893 Olfactory receptor 3a2 dto:DTO_02100563 An olfactory receptor 3A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47888] https://pharos.nih.gov/idg/targets/P47888 OR3A3 OR3A6 OR3A7 OR3A8P P47888 Olfactory receptor 3A3 dto:DTO_02100564 An olfactory receptor 3A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47883] https://pharos.nih.gov/idg/targets/P47883 OR3A4P OR3A4 OR3A5P P47883 Putative olfactory receptor 3a4 dto:DTO_02100565 https://pharos.nih.gov/idg/targets/Q8NGN8 OR4A4P Q8NGN8 Putative olfactory receptor 4A4 dto:DTO_02100566 An olfactory receptor 4A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH83] https://pharos.nih.gov/idg/targets/Q8NH83 OR4A5 Q8NH83 Olfactory receptor 4A5 dto:DTO_02100567 https://pharos.nih.gov/idg/targets/P0C604 OR4A8P OR4A8 P0C604 Olfactory receptor 4A8 dto:DTO_02100568 An olfactory receptor 4B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF8] https://pharos.nih.gov/idg/targets/Q8NGF8 OR4B1 Q8NGF8 Olfactory receptor 4B1 dto:DTO_02100569 An olfactory receptor 4C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH37] https://pharos.nih.gov/idg/targets/Q8NH37 OR4C3 Q8NH37 Olfactory receptor 4C3 dto:DTO_02100570 An olfactory receptor 4C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB2] https://pharos.nih.gov/idg/targets/Q8NGB2 OR4C5 Q8NGB2 Olfactory receptor 4c5 dto:DTO_02100571 An olfactory receptor 4C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH72] https://pharos.nih.gov/idg/targets/Q8NH72 OR4C6 Q8NH72 Olfactory receptor 4c6 dto:DTO_02100572 An olfactory receptor 4C11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEV9] https://pharos.nih.gov/idg/targets/Q6IEV9 OR4C11 OR4C11P Q6IEV9 Olfactory receptor 4c11 dto:DTO_02100573 An olfactory receptor 4C12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R67] https://pharos.nih.gov/idg/targets/Q96R67 OR4C12 Q96R67 Olfactory receptor 4C12 dto:DTO_02100574 An olfactory receptor 4C13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP0] https://pharos.nih.gov/idg/targets/Q8NGP0 OR4C13 Q8NGP0 Olfactory receptor 4c13 dto:DTO_02100575 An olfactory receptor 4C15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM1] https://pharos.nih.gov/idg/targets/Q8NGM1 OR4C15 Q8NGM1 Olfactory receptor 4c15 dto:DTO_02100576 An olfactory receptor 4C16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL9] https://pharos.nih.gov/idg/targets/Q8NGL9 OR4C16 Q8NGL9 Olfactory receptor 4c16 dto:DTO_02100577 An olfactory receptor 4D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15615] https://pharos.nih.gov/idg/targets/Q15615 OR4D1 OR4D3 Q15615 Olfactory receptor 4D1 dto:DTO_02100578 An olfactory receptor 4D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58180] https://pharos.nih.gov/idg/targets/P58180 OR4D2 P58180 Olfactory receptor 4D2 dto:DTO_02100579 An olfactory receptor 4D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN0] https://pharos.nih.gov/idg/targets/Q8NGN0 OR4D5 Q8NGN0 Olfactory receptor 4D5 dto:DTO_02100580 An olfactory receptor 4D6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ1] https://pharos.nih.gov/idg/targets/Q8NGJ1 OR4D6 Q8NGJ1 Olfactory receptor 4D6 dto:DTO_02100581 An olfactory receptor 4D9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE8] https://pharos.nih.gov/idg/targets/Q8NGE8 OR4D9 Q8NGE8 Olfactory receptor 4d9 dto:DTO_02100582 An olfactory receptor 4D10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI6] https://pharos.nih.gov/idg/targets/Q8NGI6 OR4D10 OR4D10P Q8NGI6 Olfactory receptor 4D10 dto:DTO_02100583 An olfactory receptor 4D11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI4] https://pharos.nih.gov/idg/targets/Q8NGI4 OR4D11 OR4D11P Q8NGI4 Olfactory receptor 4D11 dto:DTO_02100584 An olfactory receptor 4E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C645] https://pharos.nih.gov/idg/targets/P0C645 OR4E1 OR4E1P P0C645 Olfactory receptor 4E1 dto:DTO_02100585 An olfactory receptor 4E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC2] https://pharos.nih.gov/idg/targets/Q8NGC2 OR4E2 Q8NGC2 Olfactory receptor 4E2 dto:DTO_02100586 An olfactory receptor 4F3/4F16/4F29 that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q6IEY1 OR4F3 OR4F16 OR4F29 Q6IEY1 Olfactory receptor 4f3/4f16/4f29 dto:DTO_02100587 An olfactory receptor 4F4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R69] https://pharos.nih.gov/idg/targets/Q96R69 OR4F4 Q96R69 Olfactory receptor 4F4 dto:DTO_02100588 An olfactory receptor 4F5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH21] https://pharos.nih.gov/idg/targets/Q8NH21 OR4F5 Q8NH21 Olfactory receptor 4F5 dto:DTO_02100589 An olfactory receptor 4F6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB9] https://pharos.nih.gov/idg/targets/Q8NGB9 OR4F6 OR4F12 Q8NGB9 Olfactory receptor 4f6 dto:DTO_02100590 An olfactory receptor 4K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD4] https://pharos.nih.gov/idg/targets/Q8NGD4 OR4K1 Q8NGD4 Olfactory receptor 4k1 dto:DTO_02100591 An olfactory receptor 4K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD2] https://pharos.nih.gov/idg/targets/Q8NGD2 OR4K2 Q8NGD2 Olfactory receptor 4K2 dto:DTO_02100592 An olfactory receptor 4K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R72] https://pharos.nih.gov/idg/targets/Q96R72 OR4K3 OR4K3P Q96R72 Olfactory receptor 4k3 dto:DTO_02100593 An olfactory receptor 4K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD3] https://pharos.nih.gov/idg/targets/Q8NGD3 OR4K5 Q8NGD3 Olfactory receptor 4K5 dto:DTO_02100594 An olfactory receptor 4K13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH42] https://pharos.nih.gov/idg/targets/Q8NH42 OR4K13 Q8NH42 Olfactory receptor 4K13 dto:DTO_02100595 An olfactory receptor 4K14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD5] https://pharos.nih.gov/idg/targets/Q8NGD5 OR4K14 Q8NGD5 Olfactory receptor 4k14 dto:DTO_02100596 An olfactory receptor 4K15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH41] https://pharos.nih.gov/idg/targets/Q8NH41 OR4K15 Q8NH41 Olfactory receptor 4K15 dto:DTO_02100597 An olfactory receptor 4K17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC6] https://pharos.nih.gov/idg/targets/Q8NGC6 OR4K17 Q8NGC6 Olfactory receptor 4k17 dto:DTO_02100598 An olfactory receptor 4L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH43] https://pharos.nih.gov/idg/targets/Q8NH43 OR4L1 OR4L2P Q8NH43 Olfactory receptor 4L1 dto:DTO_02100599 An olfactory receptor 4M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD0] https://pharos.nih.gov/idg/targets/Q8NGD0 OR4M1 Q8NGD0 Olfactory receptor 4M1 dto:DTO_02100600 An olfactory receptor 4M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB6] https://pharos.nih.gov/idg/targets/Q8NGB6 OR4M2 Q8NGB6 Olfactory receptor 4M2 dto:DTO_02100601 An olfactory receptor 4N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD1] https://pharos.nih.gov/idg/targets/Q8NGD1 OR4N2 Q8NGD1 Olfactory receptor 4n2 dto:DTO_02100602 An olfactory receptor 4N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y3] https://pharos.nih.gov/idg/targets/Q8N0Y3 OR4N4 Q8N0Y3 Olfactory receptor 4N4 dto:DTO_02100603 An olfactory receptor 4N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IXE1] https://pharos.nih.gov/idg/targets/Q8IXE1 OR4N5 Q8IXE1 Olfactory receptor 4N5 dto:DTO_02100604 An olfactory receptor 4P4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL7] https://pharos.nih.gov/idg/targets/Q8NGL7 OR4P4 OR4P3P Q8NGL7 Olfactory receptor 4P4 dto:DTO_02100605 An olfactory receptor 4Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C623] https://pharos.nih.gov/idg/targets/P0C623 OR4Q2 OR4Q2P P0C623 Olfactory receptor 4q2 dto:DTO_02100606 An olfactory receptor 4Q3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH05] https://pharos.nih.gov/idg/targets/Q8NH05 OR4Q3 C14orf13 OR4Q4 Q8NH05 Olfactory receptor 4Q3 dto:DTO_02100607 An olfactory receptor 4S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB4] https://pharos.nih.gov/idg/targets/Q8NGB4 OR4S1 Q8NGB4 Olfactory receptor 4S1 dto:DTO_02100608 An olfactory receptor 4S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH73] https://pharos.nih.gov/idg/targets/Q8NH73 OR4S2 OR4S2P Q8NH73 Olfactory receptor 4s2 dto:DTO_02100609 An olfactory receptor 4X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH49] https://pharos.nih.gov/idg/targets/Q8NH49 OR4X1 Q8NH49 Olfactory receptor 4x1 dto:DTO_02100610 An olfactory receptor 4X2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF9] https://pharos.nih.gov/idg/targets/Q8NGF9 OR4X2 Q8NGF9 Olfactory receptor 4X2 dto:DTO_02100611 An olfactory receptor 5A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ0] https://pharos.nih.gov/idg/targets/Q8NGJ0 OR5A1 OR5A1P Q8NGJ0 Olfactory receptor 5A1 dto:DTO_02100612 An olfactory receptor 5A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI9] https://pharos.nih.gov/idg/targets/Q8NGI9 OR5A2 Q8NGI9 Olfactory receptor 5a2 dto:DTO_02100613 An olfactory receptor 5B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R09] https://pharos.nih.gov/idg/targets/Q96R09 OR5B2 Q96R09 Olfactory receptor 5B2 dto:DTO_02100614 An olfactory receptor 5B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH48] https://pharos.nih.gov/idg/targets/Q8NH48 OR5B3 OR5B13 Q8NH48 Olfactory receptor 5b3 dto:DTO_02100615 An olfactory receptor 5B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R08] https://pharos.nih.gov/idg/targets/Q96R08 OR5B12 OR5B12P OR5B16 Q96R08 Olfactory receptor 5b12 dto:DTO_02100616 An olfactory receptor 5B17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF7] https://pharos.nih.gov/idg/targets/Q8NGF7 OR5B17 OR5B20P Q8NGF7 Olfactory receptor 5B17 dto:DTO_02100617 An olfactory receptor 5B21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL26] https://pharos.nih.gov/idg/targets/A6NL26 OR5B21 A6NL26 Olfactory receptor 5B21 dto:DTO_02100618 An olfactory receptor 5C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR4] https://pharos.nih.gov/idg/targets/Q8NGR4 OR5C1 OR5C2P Q8NGR4 Olfactory receptor 5C1 dto:DTO_02100619 An olfactory receptor 5D13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL4] https://pharos.nih.gov/idg/targets/Q8NGL4 OR5D13 Q8NGL4 Olfactory receptor 5d13 dto:DTO_02100620 An olfactory receptor 5D14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL3] https://pharos.nih.gov/idg/targets/Q8NGL3 OR5D14 Q8NGL3 Olfactory receptor 5d14 dto:DTO_02100621 An olfactory receptor 5D16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK9] https://pharos.nih.gov/idg/targets/Q8NGK9 OR5D16 Q8NGK9 Olfactory receptor 5d16 dto:DTO_02100622 An olfactory receptor 5D18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL1] https://pharos.nih.gov/idg/targets/Q8NGL1 OR5D18 Q8NGL1 Olfactory receptor 5d18 dto:DTO_02100623 An olfactory receptor 5F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95221] https://pharos.nih.gov/idg/targets/O95221 OR5F1 O95221 Olfactory receptor 5F1 dto:DTO_02100624 An olfactory receptor 5G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C626] https://pharos.nih.gov/idg/targets/P0C626 OR5G3 OR5G3P OR5G6P P0C626 Olfactory receptor 5G3 dto:DTO_02100625 An olfactory receptor 5H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NKK0] https://pharos.nih.gov/idg/targets/A6NKK0 OR5H1 A6NKK0 Olfactory receptor 5H1 dto:DTO_02100626 An olfactory receptor 5H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV7] https://pharos.nih.gov/idg/targets/Q8NGV7 OR5H2 Q8NGV7 Olfactory receptor 5h2 dto:DTO_02100627 An olfactory receptor 5H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV6] https://pharos.nih.gov/idg/targets/Q8NGV6 OR5H6 Q8NGV6 Olfactory receptor 5H6 dto:DTO_02100628 An olfactory receptor 5I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13606] https://pharos.nih.gov/idg/targets/Q13606 OR5I1 OLF1 Q13606 Olfactory receptor 5I1 dto:DTO_02100629 An olfactory receptor 5J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH18] https://pharos.nih.gov/idg/targets/Q8NH18 OR5J2 Q8NH18 Olfactory receptor 5J2 dto:DTO_02100630 An olfactory receptor 5K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB7] https://pharos.nih.gov/idg/targets/Q8NHB7 OR5K1 Q8NHB7 Olfactory receptor 5K1 dto:DTO_02100631 An olfactory receptor 5K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB8] https://pharos.nih.gov/idg/targets/Q8NHB8 OR5K2 Q8NHB8 Olfactory receptor 5k2 dto:DTO_02100632 An olfactory receptor 5K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NET4] https://pharos.nih.gov/idg/targets/A6NET4 OR5K3 A6NET4 Olfactory receptor 5K3 dto:DTO_02100633 An olfactory receptor 5K4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMS3] https://pharos.nih.gov/idg/targets/A6NMS3 OR5K4 A6NMS3 Olfactory receptor 5k4 dto:DTO_02100634 An olfactory receptor 5L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL2] https://pharos.nih.gov/idg/targets/Q8NGL2 OR5L1 Q8NGL2 Olfactory receptor 5l1 dto:DTO_02100635 An olfactory receptor 5L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL0] https://pharos.nih.gov/idg/targets/Q8NGL0 OR5L2 Q8NGL0 Olfactory receptor 5l2 dto:DTO_02100636 An olfactory receptor 5M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP8] https://pharos.nih.gov/idg/targets/Q8NGP8 OR5M1 Q8NGP8 Olfactory receptor 5M1 dto:DTO_02100637 An olfactory receptor 5M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP4] https://pharos.nih.gov/idg/targets/Q8NGP4 OR5M3 Q8NGP4 Olfactory receptor 5m3 dto:DTO_02100638 An olfactory receptor 5M8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP6] https://pharos.nih.gov/idg/targets/Q8NGP6 OR5M8 Q8NGP6 Olfactory receptor 5M8 dto:DTO_02100639 An olfactory receptor 5M9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP3] https://pharos.nih.gov/idg/targets/Q8NGP3 OR5M9 Q8NGP3 Olfactory receptor 5M9 dto:DTO_02100640 An olfactory receptor 5M10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEU7] https://pharos.nih.gov/idg/targets/Q6IEU7 OR5M10 Q6IEU7 Olfactory receptor 5m10 dto:DTO_02100641 An olfactory receptor 5M11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RB7] https://pharos.nih.gov/idg/targets/Q96RB7 OR5M11 Q96RB7 Olfactory receptor 5M11 dto:DTO_02100642 An olfactory receptor 5P2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ92] https://pharos.nih.gov/idg/targets/Q8WZ92 OR5P2 Q8WZ92 Olfactory receptor 5P2 dto:DTO_02100643 An olfactory receptor 5P3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ94] https://pharos.nih.gov/idg/targets/Q8WZ94 OR5P3 Q8WZ94 Olfactory receptor 5P3 dto:DTO_02100644 An olfactory receptor 5R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH85] https://pharos.nih.gov/idg/targets/Q8NH85 OR5R1 OR5R1P Q8NH85 Olfactory receptor 5r1 dto:DTO_02100645 An olfactory receptor 5T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG75] https://pharos.nih.gov/idg/targets/Q8NG75 OR5T1 OR5T1P Q8NG75 Olfactory receptor 5T1 dto:DTO_02100646 An olfactory receptor 5T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG2] https://pharos.nih.gov/idg/targets/Q8NGG2 OR5T2 Q8NGG2 Olfactory receptor 5t2 dto:DTO_02100647 An olfactory receptor 5T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG3] https://pharos.nih.gov/idg/targets/Q8NGG3 OR5T3 Q8NGG3 Olfactory receptor 5T3 dto:DTO_02100648 An olfactory receptor 5V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF6] https://pharos.nih.gov/idg/targets/Q9UGF6 OR5V1 Q9UGF6 Olfactory receptor 5V1 dto:DTO_02100649 An olfactory receptor 5W2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH69] https://pharos.nih.gov/idg/targets/Q8NH69 OR5W2 OR5W2P OR5W3P Q8NH69 Olfactory receptor 5w2 dto:DTO_02100650 An olfactory receptor 6A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95222] https://pharos.nih.gov/idg/targets/O95222 OR6A2 OR6A1 OR6A2P O95222 Olfactory receptor 6a2 dto:DTO_02100651 An olfactory receptor 6B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95007] https://pharos.nih.gov/idg/targets/O95007 OR6B1 O95007 Olfactory receptor 6b1 dto:DTO_02100652 An olfactory receptor 6B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFH4] https://pharos.nih.gov/idg/targets/Q6IFH4 OR6B2 OR6B2P Q6IFH4 Olfactory receptor 6b2 dto:DTO_02100653 An olfactory receptor 6B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW1] https://pharos.nih.gov/idg/targets/Q8NGW1 OR6B3 OR6B3P Q8NGW1 Olfactory receptor 6b3 dto:DTO_02100654 An olfactory receptor 6C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD1] https://pharos.nih.gov/idg/targets/Q96RD1 OR6C1 Q96RD1 Olfactory receptor 6c1 dto:DTO_02100655 An olfactory receptor 6C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP2] https://pharos.nih.gov/idg/targets/Q9NZP2 OR6C2 Q9NZP2 Olfactory receptor 6c2 dto:DTO_02100656 An olfactory receptor 6C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP0] https://pharos.nih.gov/idg/targets/Q9NZP0 OR6C3 Q9NZP0 Olfactory receptor 6c3 dto:DTO_02100657 An olfactory receptor 6C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE1] https://pharos.nih.gov/idg/targets/Q8NGE1 OR6C4 Q8NGE1 Olfactory receptor 6c4 dto:DTO_02100658 An olfactory receptor 6C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NF89] https://pharos.nih.gov/idg/targets/A6NF89 OR6C6 A6NF89 Olfactory receptor 6c6 dto:DTO_02100659 An olfactory receptor 6F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ6] https://pharos.nih.gov/idg/targets/Q8NGZ6 OR6F1 Q8NGZ6 Olfactory receptor 6f1 dto:DTO_02100660 An olfactory receptor 6J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC5] https://pharos.nih.gov/idg/targets/Q8NGC5 OR6J1 OR6J2 Q8NGC5 Olfactory receptor 6J1 dto:DTO_02100661 An olfactory receptor 6K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY2] https://pharos.nih.gov/idg/targets/Q8NGY2 OR6K2 Q8NGY2 Olfactory receptor 6K2 dto:DTO_02100662 An olfactory receptor 6K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY3] https://pharos.nih.gov/idg/targets/Q8NGY3 OR6K3 Q8NGY3 Olfactory receptor 6K3 dto:DTO_02100663 An olfactory receptor 6K6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW6] https://pharos.nih.gov/idg/targets/Q8NGW6 OR6K6 Q8NGW6 Olfactory receptor 6k6 dto:DTO_02100664 An olfactory receptor 6M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM8] https://pharos.nih.gov/idg/targets/Q8NGM8 OR6M1 Q8NGM8 Olfactory receptor 6M1 dto:DTO_02100665 An olfactory receptor 6N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY5] https://pharos.nih.gov/idg/targets/Q8NGY5 OR6N1 Q8NGY5 Olfactory receptor 6n1 dto:DTO_02100666 An olfactory receptor 6N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY6] https://pharos.nih.gov/idg/targets/Q8NGY6 OR6N2 Q8NGY6 Olfactory receptor 6N2 dto:DTO_02100667 An olfactory receptor 6P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX9] https://pharos.nih.gov/idg/targets/Q8NGX9 OR6P1 Q8NGX9 Olfactory receptor 6p1 dto:DTO_02100668 An olfactory receptor 6Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ2] https://pharos.nih.gov/idg/targets/Q8NGQ2 OR6Q1 Q8NGQ2 Olfactory receptor 6Q1 dto:DTO_02100669 An olfactory receptor 6S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH40] https://pharos.nih.gov/idg/targets/Q8NH40 OR6S1 Q8NH40 Olfactory receptor 6S1 dto:DTO_02100670 An olfactory receptor 6T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN1] https://pharos.nih.gov/idg/targets/Q8NGN1 OR6T1 Q8NGN1 Olfactory receptor 6t1 dto:DTO_02100671 An olfactory receptor 6V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N148] https://pharos.nih.gov/idg/targets/Q8N148 OR6V1 Q8N148 Olfactory receptor 6V1 dto:DTO_02100672 An olfactory receptor 6X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH79] https://pharos.nih.gov/idg/targets/Q8NH79 OR6X1 Q8NH79 Olfactory receptor 6x1 dto:DTO_02100673 An olfactory receptor 6Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX8] https://pharos.nih.gov/idg/targets/Q8NGX8 OR6Y1 OR6Y2 Q8NGX8 Olfactory receptor 6y1 dto:DTO_02100674 https://pharos.nih.gov/idg/targets/Q8NGA2 OR7A2P OR7A2 OR7A7 Q8NGA2 Putative olfactory receptor 7a2 dto:DTO_02100675 An olfactory receptor 7A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15622] https://pharos.nih.gov/idg/targets/Q15622 OR7A5 Q15622 Olfactory receptor 7A5 dto:DTO_02100676 An olfactory receptor 7A10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76100] https://pharos.nih.gov/idg/targets/O76100 OR7A10 O76100 Olfactory receptor 7A10 dto:DTO_02100677 An olfactory receptor 7A17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14581] https://pharos.nih.gov/idg/targets/O14581 OR7A17 O14581 Olfactory receptor 7a17 dto:DTO_02100678 An olfactory receptor 7C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76099] https://pharos.nih.gov/idg/targets/O76099 OR7C1 OR7C4 O76099 Olfactory receptor 7c1 dto:DTO_02100679 An olfactory receptor 7C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60412] https://pharos.nih.gov/idg/targets/O60412 OR7C2 OR7C3 O60412 Olfactory receptor 7c2 dto:DTO_02100680 An olfactory receptor 7D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RA2] https://pharos.nih.gov/idg/targets/Q96RA2 OR7D2 Q96RA2 Olfactory receptor 7d2 dto:DTO_02100681 An olfactory receptor 7D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG98] https://pharos.nih.gov/idg/targets/Q8NG98 OR7D4 OR7D4P Q8NG98 Olfactory receptor 7d4 dto:DTO_02100682 An olfactory receptor 7G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA0] https://pharos.nih.gov/idg/targets/Q8NGA0 OR7G1 OR7G1P Q8NGA0 Olfactory receptor 7G1 dto:DTO_02100683 An olfactory receptor 7G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG99] https://pharos.nih.gov/idg/targets/Q8NG99 OR7G2 Q8NG99 Olfactory receptor 7G2 dto:DTO_02100684 An olfactory receptor 7G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG95] https://pharos.nih.gov/idg/targets/Q8NG95 OR7G3 Q8NG95 Olfactory receptor 7G3 dto:DTO_02100685 An olfactory receptor 8A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG7] https://pharos.nih.gov/idg/targets/Q8NGG7 OR8A1 Q8NGG7 Olfactory receptor 8A1 dto:DTO_02100686 An olfactory receptor 8B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD0] https://pharos.nih.gov/idg/targets/Q96RD0 OR8B2 Q96RD0 Olfactory receptor 8b2 dto:DTO_02100687 An olfactory receptor 8B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG8] https://pharos.nih.gov/idg/targets/Q8NGG8 OR8B3 Q8NGG8 Olfactory receptor 8b3 dto:DTO_02100688 An olfactory receptor 8B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RC9] https://pharos.nih.gov/idg/targets/Q96RC9 OR8B4 OR8B4P Q96RC9 Olfactory receptor 8b4 dto:DTO_02100689 An olfactory receptor 8B8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15620] https://pharos.nih.gov/idg/targets/Q15620 OR8B8 Q15620 Olfactory receptor 8B8 dto:DTO_02100690 An olfactory receptor 8B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG6] https://pharos.nih.gov/idg/targets/Q8NGG6 OR8B12 Q8NGG6 Olfactory receptor 8B12 dto:DTO_02100691 An olfactory receptor 8D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ84] https://pharos.nih.gov/idg/targets/Q8WZ84 OR8D1 OR8D3 Q8WZ84 Olfactory receptor 8D1 dto:DTO_02100692 An olfactory receptor 8D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZM6] https://pharos.nih.gov/idg/targets/Q9GZM6 OR8D2 Q9GZM6 Olfactory receptor 8D2 dto:DTO_02100693 An olfactory receptor 8D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM9] https://pharos.nih.gov/idg/targets/Q8NGM9 OR8D4 Q8NGM9 Olfactory receptor 8D4 dto:DTO_02100694 An olfactory receptor 8G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15617] https://pharos.nih.gov/idg/targets/Q15617 OR8G1 OR8G1P Q15617 Olfactory receptor 8G1 dto:DTO_02100695 An olfactory receptor 8G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15614] https://pharos.nih.gov/idg/targets/Q6IF36 OR8G2 OR8G2P OR8G4 Q6IF36 Olfactory receptor 8G2 dto:DTO_02100696 An olfactory receptor 8G5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG78] https://pharos.nih.gov/idg/targets/Q8NG78 OR8G5 OR8G5P OR8G6 Q8NG78 Olfactory receptor 8G5 dto:DTO_02100697 An olfactory receptor 8H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG4] https://pharos.nih.gov/idg/targets/Q8NGG4 OR8H1 Q8NGG4 Olfactory receptor 8h1 dto:DTO_02100698 An olfactory receptor 8H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N162] https://pharos.nih.gov/idg/targets/Q8N162 OR8H2 Q8N162 Olfactory receptor 8h2 dto:DTO_02100699 An olfactory receptor 8H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N146] https://pharos.nih.gov/idg/targets/Q8N146 OR8H3 Q8N146 Olfactory receptor 8h3 dto:DTO_02100700 An olfactory receptor 8I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y5] https://pharos.nih.gov/idg/targets/Q8N0Y5 OR8I2 Q8N0Y5 Olfactory receptor 8I2 dto:DTO_02100701 An olfactory receptor 8J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP2] https://pharos.nih.gov/idg/targets/Q8NGP2 OR8J1 Q8NGP2 Olfactory receptor 8j1 dto:DTO_02100702 An olfactory receptor 8J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG1] https://pharos.nih.gov/idg/targets/Q8NGG1 OR8J2 OR8J2P Q8NGG1 Olfactory receptor 8j2 dto:DTO_02100703 An olfactory receptor 8J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG0] https://pharos.nih.gov/idg/targets/Q8NGG0 OR8J3 Q8NGG0 Olfactory receptor 8J3 dto:DTO_02100704 An olfactory receptor 8K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG5] https://pharos.nih.gov/idg/targets/Q8NGG5 OR8K1 Q8NGG5 Olfactory receptor 8K1 dto:DTO_02100705 An olfactory receptor 8K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH51] https://pharos.nih.gov/idg/targets/Q8NH51 OR8K3 Q8NH51 Olfactory receptor 8K3 dto:DTO_02100706 An olfactory receptor 8K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH50] https://pharos.nih.gov/idg/targets/Q8NH50 OR8K5 Q8NH50 Olfactory receptor 8K5 dto:DTO_02100707 An olfactory receptor 8S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH09] https://pharos.nih.gov/idg/targets/Q8NH09 OR8S1 Q8NH09 Olfactory receptor 8s1 dto:DTO_02100708 An olfactory receptor 8U1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH10] https://pharos.nih.gov/idg/targets/Q8NH10 OR8U1 Q8NH10 Olfactory receptor 8u1 dto:DTO_02100709 An olfactory receptor 8U8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N1] https://pharos.nih.gov/idg/targets/P0C7N1 OR8U8 P0C7N1 Olfactory receptor 8u8 dto:DTO_02100710 An olfactory receptor 8U9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N5] https://pharos.nih.gov/idg/targets/P0C7N5 OR8U9 P0C7N5 Olfactory receptor 8U9 dto:DTO_02100711 https://pharos.nih.gov/idg/targets/Q8NGU1 OR9A1P OR9A1 Q8NGU1 Putative olfactory receptor 9A1 dto:DTO_02100712 An olfactory receptor 9A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT5] https://pharos.nih.gov/idg/targets/Q8NGT5 OR9A2 Q8NGT5 Olfactory receptor 9A2 dto:DTO_02100713 An olfactory receptor 9A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGU2] https://pharos.nih.gov/idg/targets/Q8NGU2 OR9A4 Q8NGU2 Olfactory receptor 9A4 dto:DTO_02100714 An olfactory receptor 9G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH87] https://pharos.nih.gov/idg/targets/Q8NH87 OR9G1 OR9G5 Q8NH87 Olfactory receptor 9g1 dto:DTO_02100715 An olfactory receptor 9G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ1] https://pharos.nih.gov/idg/targets/Q8NGQ1 OR9G4 Q8NGQ1 Olfactory receptor 9G4 dto:DTO_02100716 An olfactory receptor 9G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N8] https://pharos.nih.gov/idg/targets/P0C7N8 OR9G9 P0C7N8 Olfactory receptor 9g9 dto:DTO_02100717 An olfactory receptor 9I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ6] https://pharos.nih.gov/idg/targets/Q8NGQ6 OR9I1 Q8NGQ6 Olfactory receptor 9I1 dto:DTO_02100718 An olfactory receptor 9K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE7] https://pharos.nih.gov/idg/targets/Q8NGE7 OR9K2 Q8NGE7 Olfactory receptor 9K2 dto:DTO_02100719 An olfactory receptor 9Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ5] https://pharos.nih.gov/idg/targets/Q8NGQ5 OR9Q1 Q8NGQ5 Olfactory receptor 9Q1 dto:DTO_02100720 An olfactory receptor 9Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE9] https://pharos.nih.gov/idg/targets/Q8NGE9 OR9Q2 OR9Q2P Q8NGE9 Olfactory receptor 9Q2 dto:DTO_02100721 An orexin receptor type 1 that is encoded in the genome of human. [Reactome:REACT_17344] https://pharos.nih.gov/idg/targets/O43613 HCRTR1 O43613 Orexin receptor type 1 dto:DTO_02100722 An orexin receptor type 2 that is encoded in the genome of human. [Reactome:REACT_17071] https://pharos.nih.gov/idg/targets/O43614 HCRTR2 O43614 Orexin receptor type 2 dto:DTO_02100723 An oxoeicosanoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS5] https://pharos.nih.gov/idg/targets/Q8TDS5 OXER1 GPR170 TG1019 Q8TDS5 Oxoeicosanoid receptor 1 dto:DTO_02100724 A 2-oxoglutarate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P68] https://pharos.nih.gov/idg/targets/Q96P68 OXGR1 GPR80 GPR99 P2RY15 P2Y15 Q96P68 2-oxoglutarate receptor 1 dto:DTO_02100725 An oxytocin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30559] https://pharos.nih.gov/idg/targets/P30559 OXTR P30559 Oxytocin receptor dto:DTO_02100726 A P2Y purinoceptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47900] https://pharos.nih.gov/idg/targets/P47900 P2RY1 P47900 P2y purinoceptor 1 dto:DTO_02100727 A P2Y purinoceptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41231] https://pharos.nih.gov/idg/targets/P41231 P2RY2 P2RU1 P41231 P2y purinoceptor 2 dto:DTO_02100728 A P2Y purinoceptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51582] https://pharos.nih.gov/idg/targets/P51582 P2RY4 NRU P51582 P2Y purinoceptor 4 dto:DTO_02100729 A P2Y purinoceptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15077] https://pharos.nih.gov/idg/targets/Q15077 P2RY6 Q15077 P2y purinoceptor 6 dto:DTO_02100730 A P2Y purinoceptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86VZ1] https://pharos.nih.gov/idg/targets/Q86VZ1 P2RY8 Q86VZ1 P2Y purinoceptor 8 dto:DTO_02100731 A P2Y purinoceptor 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00398] https://pharos.nih.gov/idg/targets/O00398 P2RY10 O00398 Putative P2Y purinoceptor 10 dto:DTO_02100732 A P2Y purinoceptor 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96G91] https://pharos.nih.gov/idg/targets/Q96G91 P2RY11 Q96G91 P2Y purinoceptor 11 dto:DTO_02100733 A P2Y purinoceptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H244] https://pharos.nih.gov/idg/targets/Q9H244 P2RY12 HORK3 Q9H244 P2y purinoceptor 12 dto:DTO_02100734 A P2Y purinoceptor 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BPV8] https://pharos.nih.gov/idg/targets/Q9BPV8 P2RY13 GPR86 GPR94 Q9BPV8 P2Y purinoceptor 13 dto:DTO_02100735 A P2Y purinoceptor 14 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15391] https://pharos.nih.gov/idg/targets/Q15391 P2RY14 GPR105 KIAA0001 Q15391 P2y purinoceptor 14 dto:DTO_02100736 A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41586] https://pharos.nih.gov/idg/targets/P41586 ADCYAP1R1 P41586 Pituitary adenylate cyclase-activating polypeptide type I receptor dto:DTO_02100737 A proteinase-activated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25116] https://pharos.nih.gov/idg/targets/P25116 F2R CF2R PAR1 TR P25116 Proteinase-activated receptor 1 dto:DTO_02100738 A proteinase-activated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P55085] https://pharos.nih.gov/idg/targets/P55085 F2RL1 GPR11 PAR2 P55085 Proteinase-activated receptor 2 dto:DTO_02100739 A proteinase-activated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00254] https://pharos.nih.gov/idg/targets/O00254 F2RL2 PAR3 O00254 Proteinase-activated receptor 3 dto:DTO_02100740 A proteinase-activated receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI0] https://pharos.nih.gov/idg/targets/Q96RI0 F2RL3 PAR4 Q96RI0 Proteinase-activated receptor 4 dto:DTO_02100741 A prostaglandin D2 receptor DP2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y4] https://pharos.nih.gov/idg/targets/Q9Y5Y4 PTGDR2 CRTH2 DL1R GPR44 Q9Y5Y4 Prostaglandin d2 receptor 2 dto:DTO_02100742 A prostaglandin D2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13258] https://pharos.nih.gov/idg/targets/Q13258 PTGDR Q13258 Prostaglandin D2 receptor dto:DTO_02100743 A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34995] https://pharos.nih.gov/idg/targets/P34995 PTGER1 P34995 Prostaglandin e2 receptor ep1 subtype dto:DTO_02100744 A prostaglandin E2 receptor EP2 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43116] https://pharos.nih.gov/idg/targets/P43116 PTGER2 P43116 Prostaglandin E2 receptor EP2 subtype dto:DTO_02100745 A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43115] https://pharos.nih.gov/idg/targets/P43115 PTGER3 P43115 Prostaglandin E2 receptor EP3 subtype dto:DTO_02100746 A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35408] https://pharos.nih.gov/idg/targets/P35408 PTGER4 PTGER2 P35408 Prostaglandin E2 receptor EP4 subtype dto:DTO_02100747 A prostaglandin F2-alpha receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43088] https://pharos.nih.gov/idg/targets/P43088 PTGFR P43088 Prostaglandin F2-alpha receptor dto:DTO_02100748 A prostacyclin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43119] https://pharos.nih.gov/idg/targets/P43119 PTGIR PRIPR P43119 Prostacyclin receptor dto:DTO_02100749 A prokineticin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TCW9] https://pharos.nih.gov/idg/targets/Q8TCW9 PROKR1 GPR73 PKR1 Q8TCW9 Prokineticin receptor 1 dto:DTO_02100750 A prokineticin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NFJ6] https://pharos.nih.gov/idg/targets/Q8NFJ6 PROKR2 GPR73L1 PKR2 Q8NFJ6 Prokineticin receptor 2 dto:DTO_02100751 A prolactin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49683] https://pharos.nih.gov/idg/targets/P49683 PRLHR GPR10 GR3 P49683 Prolactin-releasing peptide receptor dto:DTO_02100752 A psychosine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IYL9] https://pharos.nih.gov/idg/targets/Q8IYL9 GPR65 TDAG8 Q8IYL9 Psychosine receptor dto:DTO_02100753 A platelet-activating factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25105] https://pharos.nih.gov/idg/targets/P25105 PTAFR PAFR P25105 Platelet-activating factor receptor dto:DTO_02100754 A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03431] https://pharos.nih.gov/idg/targets/Q03431 PTH1R PTHR PTHR1 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor dto:DTO_02100755 A parathyroid hormone 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49190] https://pharos.nih.gov/idg/targets/P49190 PTH2R PTHR2 P49190 Parathyroid hormone 2 receptor dto:DTO_02100756 An orexigenic neuropeptide QRFP receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P65] https://pharos.nih.gov/idg/targets/Q96P65 QRFPR GPR103 Q96P65 Pyroglutamylated RFamide peptide receptor dto:DTO_02100757 A retinoic acid-induced protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFJ5] https://pharos.nih.gov/idg/targets/Q8NFJ5 GPRC5A GPCR5A RAI3 RAIG1 Q8NFJ5 Retinoic acid-induced protein 3 dto:DTO_02100758 An RPE-retinal G protein-coupled receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47804] https://pharos.nih.gov/idg/targets/P47804 RGR P47804 RPE-retinal G protein-coupled receptor dto:DTO_02100759 A relaxin-3 receptor 1 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_21738] https://pharos.nih.gov/idg/targets/Q9NSD7 RXFP3 RLN3R1 SALPR Q9NSD7 Relaxin-3 receptor 1 dto:DTO_02100760 A relaxin-3 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU9] https://pharos.nih.gov/idg/targets/Q8TDU9 RXFP4 GPR100 RLN3R2 Q8TDU9 Relaxin-3 receptor 2 dto:DTO_02100761 A relaxin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX9] https://pharos.nih.gov/idg/targets/Q9HBX9 RXFP1 LGR7 Q9HBX9 Relaxin receptor 1 dto:DTO_02100762 A relaxin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8WXD0] https://pharos.nih.gov/idg/targets/Q8WXD0 RXFP2 GPR106 GREAT LGR8 Q8WXD0 Relaxin receptor 2 dto:DTO_02100763 A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21453] https://pharos.nih.gov/idg/targets/P21453 S1PR1 CHEDG1 EDG1 P21453 Sphingosine 1-phosphate receptor 1 dto:DTO_02100764 A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95136] https://pharos.nih.gov/idg/targets/O95136 S1PR2 EDG5 O95136 Sphingosine 1-phosphate receptor 2 dto:DTO_02100765 A sphingosine 1-phosphate receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99500] https://pharos.nih.gov/idg/targets/Q99500 S1PR3 EDG3 Q99500 Sphingosine 1-phosphate receptor 3 dto:DTO_02100766 A sphingosine 1-phosphate receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95977] https://pharos.nih.gov/idg/targets/O95977 S1PR4 EDG6 O95977 Sphingosine 1-phosphate receptor 4 dto:DTO_02100767 A sphingosine 1-phosphate receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H228] https://pharos.nih.gov/idg/targets/Q9H228 S1PR5 EDG8 Q9H228 Sphingosine 1-phosphate receptor 5 dto:DTO_02100768 A secretin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47872] https://pharos.nih.gov/idg/targets/P47872 SCTR P47872 Secretin receptor dto:DTO_02100769 A smoothened that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99835] https://pharos.nih.gov/idg/targets/Q99835 SMO SMOH Q99835 Smoothened homolog dto:DTO_02100770 A somatostatin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30872] https://pharos.nih.gov/idg/targets/P30872 SSTR1 P30872 Somatostatin receptor type 1 dto:DTO_02100771 A somatostatin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30874] https://pharos.nih.gov/idg/targets/P30874 SSTR2 P30874 Somatostatin receptor type 2 dto:DTO_02100772 A somatostatin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32745] https://pharos.nih.gov/idg/targets/P32745 SSTR3 P32745 Somatostatin receptor type 3 dto:DTO_02100773 A somatostatin receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31391] https://pharos.nih.gov/idg/targets/P31391 SSTR4 P31391 Somatostatin receptor type 4 dto:DTO_02100774 A somatostatin receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35346] https://pharos.nih.gov/idg/targets/P35346 SSTR5 P35346 Somatostatin receptor type 5 dto:DTO_02100775 A succinate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXA5] https://pharos.nih.gov/idg/targets/Q9BXA5 SUCNR1 GPR91 Q9BXA5 Succinate receptor 1 dto:DTO_02100776 A taste receptor type 2 member 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW0] https://pharos.nih.gov/idg/targets/Q9NYW0 TAS2R10 Q9NYW0 Taste receptor type 2 member 10 dto:DTO_02100777 A taste receptor type 2 member 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV9] https://pharos.nih.gov/idg/targets/Q9NYV9 TAS2R13 Q9NYV9 Taste receptor type 2 member 13 dto:DTO_02100778 A taste receptor type 2 member 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV8] https://pharos.nih.gov/idg/targets/Q9NYV8 TAS2R14 Q9NYV8 Taste receptor type 2 member 14 dto:DTO_02100779 A taste receptor type 2 member 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV7] https://pharos.nih.gov/idg/targets/Q9NYV7 TAS2R16 Q9NYV7 Taste receptor type 2 member 16 dto:DTO_02100780 A taste receptor type 2 member 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59542] https://pharos.nih.gov/idg/targets/P59542 TAS2R19 TAS2R23 TAS2R48 P59542 Taste receptor type 2 member 19 dto:DTO_02100781 A taste receptor type 2 member 20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59543] https://pharos.nih.gov/idg/targets/P59543 TAS2R20 TAS2R49 P59543 Taste receptor type 2 member 20 dto:DTO_02100782 A taste receptor type 2 member 30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59541] https://pharos.nih.gov/idg/targets/P59541 TAS2R30 TAS2R47 P59541 Taste receptor type 2 member 30 dto:DTO_02100783 A taste receptor type 2 member 44 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59538] https://pharos.nih.gov/idg/targets/P59538 TAS2R31 TAS2R44 P59538 Taste receptor type 2 member 31 dto:DTO_02100784 A taste receptor type 2 member 38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59533] https://pharos.nih.gov/idg/targets/P59533 TAS2R38 PTC P59533 Taste receptor type 2 member 38 dto:DTO_02100785 A taste receptor type 2 member 39 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59534] https://pharos.nih.gov/idg/targets/P59534 TAS2R39 P59534 Taste receptor type 2 member 39 dto:DTO_02100786 A taste receptor type 2 member 40 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59535] https://pharos.nih.gov/idg/targets/P59535 TAS2R40 GPR60 P59535 Taste receptor type 2 member 40 dto:DTO_02100787 A taste receptor type 2 member 41 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59536] https://pharos.nih.gov/idg/targets/P59536 TAS2R41 P59536 Taste receptor type 2 member 41 dto:DTO_02100788 A taste receptor type 2 member 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTR8] https://pharos.nih.gov/idg/targets/Q7RTR8 TAS2R42 TAS2R55 Q7RTR8 Taste receptor type 2 member 42 dto:DTO_02100789 A taste receptor type 2 member 43 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59537] https://pharos.nih.gov/idg/targets/P59537 TAS2R43 P59537 Taste receptor type 2 member 43 dto:DTO_02100790 A taste receptor type 2 member 46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59540] https://pharos.nih.gov/idg/targets/P59540 TAS2R46 P59540 Taste receptor type 2 member 46 dto:DTO_02100791 A taste receptor type 2 member 50 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59544] https://pharos.nih.gov/idg/targets/P59544 TAS2R50 P59544 Taste receptor type 2 member 50 dto:DTO_02100792 A taste receptor type 2 member 60 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59551] https://pharos.nih.gov/idg/targets/P59551 TAS2R60 P59551 Taste receptor type 2 member 60 dto:DTO_02100793 A taste receptor type 2 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW7] https://pharos.nih.gov/idg/targets/Q9NYW7 TAS2R1 Q9NYW7 Taste receptor type 2 member 1 dto:DTO_02100794 A taste receptor type 2 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW6] https://pharos.nih.gov/idg/targets/Q9NYW6 TAS2R3 Q9NYW6 Taste receptor type 2 member 3 dto:DTO_02100795 A taste receptor type 2 member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW5] https://pharos.nih.gov/idg/targets/Q9NYW5 TAS2R4 Q9NYW5 Taste receptor type 2 member 4 dto:DTO_02100796 A taste receptor type 2 member 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW4] https://pharos.nih.gov/idg/targets/Q9NYW4 TAS2R5 Q9NYW4 Taste receptor type 2 member 5 dto:DTO_02100797 A taste receptor type 2 member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW3] https://pharos.nih.gov/idg/targets/Q9NYW3 TAS2R7 Q9NYW3 Taste receptor type 2 member 7 dto:DTO_02100798 A taste receptor type 2 member 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW2] https://pharos.nih.gov/idg/targets/Q9NYW2 TAS2R8 Q9NYW2 Taste receptor type 2 member 8 dto:DTO_02100799 A taste receptor type 2 member 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW1] https://pharos.nih.gov/idg/targets/Q9NYW1 TAS2R9 Q9NYW1 Taste receptor type 2 member 9 dto:DTO_02100800 A thromboxane A2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21731] https://pharos.nih.gov/idg/targets/P21731 TBXA2R P21731 Thromboxane A2 receptor dto:DTO_02100801 A trace amine-associated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RJ0] https://pharos.nih.gov/idg/targets/Q96RJ0 TAAR1 TA1 TAR1 TRAR1 Q96RJ0 Trace amine-associated receptor 1 dto:DTO_02100802 A trace amine-associated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P5] https://pharos.nih.gov/idg/targets/Q9P1P5 TAAR2 GPR58 Q9P1P5 Trace amine-associated receptor 2 dto:DTO_02100803 A trace amine-associated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P4] https://pharos.nih.gov/idg/targets/Q9P1P4 TAAR3 GPR57 Q9P1P4 Putative trace amine-associated receptor 3 dto:DTO_02100804 A trace amine-associated receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14804] https://pharos.nih.gov/idg/targets/O14804 TAAR5 PNR O14804 Trace amine-associated receptor 5 dto:DTO_02100805 A trace amine-associated receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI8] https://pharos.nih.gov/idg/targets/Q96RI8 TAAR6 TA4 TAR4 TRAR4 Q96RI8 Trace amine-associated receptor 6 dto:DTO_02100806 A trace amine-associated receptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969N4] https://pharos.nih.gov/idg/targets/Q969N4 TAAR8 GPR102 TA5 TAR5 TRAR5 Q969N4 Trace amine-associated receptor 8 dto:DTO_02100807 A trace amine-associated receptor 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI9] https://pharos.nih.gov/idg/targets/Q96RI9 TAAR9 TA3 TAR3 TRAR3 Q96RI9 Trace amine-associated receptor 9 dto:DTO_02100808 A transmembrane protein adipocyte-associated 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W33] https://pharos.nih.gov/idg/targets/Q86W33 TPRA1 GPR175 TMEM227 Q86W33 Transmembrane protein adipocyte-associated 1 dto:DTO_02100809 A thyrotropin-releasing hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34981] https://pharos.nih.gov/idg/targets/P34981 TRHR P34981 Thyrotropin-releasing hormone receptor dto:DTO_02100810 A taste receptor type 1 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX1] https://pharos.nih.gov/idg/targets/Q7RTX1 TAS1R1 GPR70 T1R1 TR1 Q7RTX1 Taste receptor type 1 member 1 dto:DTO_02100811 A taste receptor type 1 member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE23] https://pharos.nih.gov/idg/targets/Q8TE23 TAS1R2 GPR71 T1R2 TR2 Q8TE23 Taste receptor type 1 member 2 dto:DTO_02100812 A taste receptor type 1 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX0] https://pharos.nih.gov/idg/targets/Q7RTX0 TAS1R3 T1R3 TR3 Q7RTX0 Taste receptor type 1 member 3 dto:DTO_02100813 A thyrotropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16473] https://pharos.nih.gov/idg/targets/P16473 TSHR LGR3 P16473 Thyrotropin receptor dto:DTO_02100814 A urotensin-2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UKP6] https://pharos.nih.gov/idg/targets/Q9UKP6 UTS2R GPR14 Q9UKP6 Urotensin-2 receptor dto:DTO_02100815 A vasopressin V1a receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P37288] https://pharos.nih.gov/idg/targets/P37288 AVPR1A AVPR1 P37288 Vasopressin v1a receptor dto:DTO_02100816 A vasopressin V1b receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47901] https://pharos.nih.gov/idg/targets/P47901 AVPR1B AVPR3 VPR3 P47901 Vasopressin v1b receptor dto:DTO_02100817 A vasopressin V2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30518] https://pharos.nih.gov/idg/targets/P30518 AVPR2 ADHR DIR DIR3 V2R P30518 Vasopressin V2 receptor dto:DTO_02100818 A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32241] https://pharos.nih.gov/idg/targets/P32241 VIPR1 P32241 Vasoactive intestinal polypeptide receptor 1 dto:DTO_02100819 A vasoactive intestinal polypeptide receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41587] https://pharos.nih.gov/idg/targets/P41587 VIPR2 VIP2R P41587 Vasoactive intestinal polypeptide receptor 2 dto:DTO_02100820 A vomeronasal type-1 receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZP7] https://pharos.nih.gov/idg/targets/Q9GZP7 VN1R1 V1RL1 VNR19I1 Q9GZP7 Vomeronasal type-1 receptor 1 dto:DTO_02100821 A vomeronasal type-1 receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFZ6] https://pharos.nih.gov/idg/targets/Q8NFZ6 VN1R2 V1RL2 Q8NFZ6 Vomeronasal type-1 receptor 2 dto:DTO_02100822 A vomeronasal type-1 receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXE9] https://pharos.nih.gov/idg/targets/Q9BXE9 VN1R3 V1RL3 Q9BXE9 Vomeronasal type-1 receptor 3 dto:DTO_02100823 A vomeronasal type-1 receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H5] https://pharos.nih.gov/idg/targets/Q7Z5H5 VN1R4 V1RL4 Q7Z5H5 Vomeronasal type-1 receptor 4 dto:DTO_02100824 A vomeronasal type-1 receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H4] https://pharos.nih.gov/idg/targets/Q7Z5H4 VN1R5 V1RL5 Q7Z5H4 Vomeronasal type-1 receptor 5 dto:DTO_02100826 A chemokine XC receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46094] https://pharos.nih.gov/idg/targets/P46094 XCR1 CCXCR1 GPR5 P46094 Chemokine xc receptor 1 dto:DTO_02100827 https://pharos.nih.gov/idg/targets/Q8NH95 OR13C6P Q8NH95 Putative olfactory receptor 13c6 dto:DTO_02100828 https://pharos.nih.gov/idg/targets/Q99463 NPY6R NPY1RL P16118 Q99463 Putative neuropeptide Y receptor type 6 dto:DTO_02100829 https://pharos.nih.gov/idg/targets/Q8TDU5 VN1R17P VNRL4 Q8TDU5 Putative vomeronasal receptor-like protein 4 dto:DTO_02200001 A 5-hydroxytryptamine receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08908] 3350 HTR1A ADRB2RL1 ADRBRL1 HTR1A gene dto:DTO_02200002 A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28222] 3351 HTR1B HTR1DB HTR1B gene dto:DTO_02200003 A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28221] 3352 HTR1D HTR1DA HTRL HTR1D gene dto:DTO_02200004 A 5-hydroxytryptamine receptor 1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28566] 3354 HTR1E HTR1E gene dto:DTO_02200005 A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30939] 3355 HTR1F HTR1EL HTR1F gene dto:DTO_02200006 A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28223] 3356 HTR2A HTR2 HTR2A gene dto:DTO_02200007 A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41595] 3357 HTR2B HTR2B gene dto:DTO_02200008 A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28335] 3358 HTR2C HTR1C HTR2C gene dto:DTO_02200009 A 5-hydroxytryptamine receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13639] 3360 HTR4 HTR4 gene dto:DTO_02200010 A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47898] 3361 HTR5A HTR5A gene dto:DTO_02200011 A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50406] 3362 HTR6 HTR6 gene dto:DTO_02200012 A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34969] 3363 HTR7 HTR7 gene dto:DTO_02200013 An adenosine receptor A1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30542] 134 ADORA1 ADORA1 gene dto:DTO_02200014 An adenosine receptor A2a that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29274] 135 ADORA2A ADORA2 ADORA2A gene dto:DTO_02200015 An adenosine receptor A2b that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29275] 136 ADORA2B ADORA2B gene dto:DTO_02200016 140 ADORA3 ADORA3 gene dto:DTO_02200017 A duffy antigen/chemokine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16570] 2532 ACKR1 DARC FY GPD ACKR1 gene dto:DTO_02200018 A chemokine-binding protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00590] 1238 ACKR2 CCBP2 CCR10 CMKBR9 D6 ACKR2 gene dto:DTO_02200019 A C-X-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25106] 57007 ACKR3 CMKOR1 CXCR7 GPR159 RDC1 ACKR3 gene dto:DTO_02200020 A C-C chemokine receptor type 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPB9] 51554 ACKR4 CCBP2 CCR11 CCRL1 VSHK1 ACKR4 gene dto:DTO_02200021 A muscarinic acetylcholine receptor M1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P11229] 1128 CHRM1 CHRM1 gene dto:DTO_02200022 A muscarinic acetylcholine receptor M2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08172] 1129 CHRM2 CHRM2 gene dto:DTO_02200023 A muscarinic acetylcholine receptor M3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P20309] 1131 CHRM3 CHRM3 gene dto:DTO_02200024 A muscarinic acetylcholine receptor M4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08173] 1132 CHRM4 CHRM4 gene dto:DTO_02200025 A muscarinic acetylcholine receptor M5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08912] 1133 CHRM5 CHRM5 gene dto:DTO_02200026 An adrenocorticotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01718] 4158 MC2R ACTHR MC2R gene dto:DTO_02200027 An alpha-1A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35348] 148 ADRA1A ADRA1C ADRA1A gene dto:DTO_02200028 An alpha-1B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35368] 147 ADRA1B ADRA1B gene dto:DTO_02200029 An alpha-1D adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25100] 146 ADRA1D ADRA1A ADRA1D gene dto:DTO_02200030 An alpha-2A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08913] 150 ADRA2A ADRA2R ADRAR ADRA2A gene dto:DTO_02200031 An alpha-2B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18089] 151 ADRA2B ADRA2L1 ADRA2RL1 ADRA2B gene dto:DTO_02200032 An alpha-2C adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18825] 152 ADRA2C ADRA2L2 ADRA2RL2 ADRA2C gene dto:DTO_02200033 A beta-1 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08588] 153 ADRB1 ADRB1R B1AR ADRB1 gene dto:DTO_02200034 A beta-2 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07550] 154 ADRB2 ADRB2R B2AR ADRB2 gene dto:DTO_02200035 A beta-3 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P13945] 155 ADRB3 ADRB3R B3AR ADRB3 gene dto:DTO_02200036 An angiotensin II receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30556] 185 AGTR1 AGTR1A AGTR1B AT2R1 AT2R1B AGTR1 gene dto:DTO_02200037 An angiotensin II receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50052] 186 AGTR2 AGTR2 gene dto:DTO_02200038 An apelin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35414] 187 APLNR AGTRL1 APJ APLNR gene dto:DTO_02200039 A brain-specific angiogenesis inhibitor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14514] 575 BAI1 ADGRB1 gene dto:DTO_02200040 A brain-specific angiogenesis inhibitor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60241] 576 BAI2 ADGRB2 gene dto:DTO_02200041 A brain-specific angiogenesis inhibitor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60242] 577 BAI3 KIAA0550 ADGRB3 gene dto:DTO_02200042 A B1 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46663] 623 BDKRB1 BRADYB1 BDKRB1 gene dto:DTO_02200043 A B2 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30411] 624 BDKRB2 BKR2 BDKRB2 gene dto:DTO_02200044 A bombesin receptor subtype-3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32247] 680 BRS3 BRS3 gene dto:DTO_02200045 A C3a anaphylatoxin chemotactic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16581] 719 C3AR1 AZ3B C3R1 HNFAG09 C3AR1 gene dto:DTO_02200046 A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21730] 728 C5AR1 C5AR C5R1 C5AR1 gene dto:DTO_02200047 A C5a anaphylatoxin chemotactic receptor C5L2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P296] 27202 C5AR2 C5L2 GPR77 C5AR2 gene dto:DTO_02200048 A calcitonin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30988] 799 CALCR CALCR gene dto:DTO_02200049 A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16602] 10203 CALCRL CGRPR CALCRL gene dto:DTO_02200050 An extracellular calcium-sensing receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41180] 846 CASR GPRC2A PCAR1 CASR gene dto:DTO_02200051 A cholecystokinin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32238] 886 CCKAR CCKRA CCKAR gene dto:DTO_02200052 A C-C chemokine receptor type 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46092] 2826 CCR10 GPR2 CCR10 gene dto:DTO_02200053 A C-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32246] 1230 CCR1 CMKBR1 CMKR1 SCYAR1 CCR1 gene dto:DTO_02200054 A C-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41597] 729230 CCR2 CMKBR2 CCR2 gene dto:DTO_02200055 A C-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51677] 1232 CCR3 CMKBR3 CCR3 gene dto:DTO_02200056 A C-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51679] 1233 CCR4 CMKBR4 CCR4 gene dto:DTO_02200057 A C-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51681] 1234 CCR5 CMKBR5 CCR5 gene dto:DTO_02200058 A C-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51684] 1235 CCR6 CKRL3 CMKBR6 GPR29 STRL22 CCR6 gene dto:DTO_02200059 A C-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32248] 1236 CCR7 CMKBR7 EBI1 EVI1 CCR7 gene dto:DTO_02200060 A C-C chemokine receptor type 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51685] 1237 CCR8 CKRL1 CMKBR8 CMKBRL2 CCR8 gene dto:DTO_02200061 A C-C chemokine receptor type 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51686] 10803 CCR9 GPR28 CCR9 gene dto:DTO_02200062 A C-C chemokine receptor-like 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00421] 9034 CCRL2 CCR11 CCR6 CKRX CRAM HCR CCRL2 gene dto:DTO_02200063 A CD97 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48960] 976 CD97 ADGRE5 gene dto:DTO_02200064 A cadherin EGF LAG seven-pass G-type receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ6] 9620 CELSR1 CDHF9 FMI2 CELSR1 gene dto:DTO_02200065 A cadherin EGF LAG seven-pass G-type receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCU4] 1952 CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 CELSR2 gene dto:DTO_02200066 A cadherin EGF LAG seven-pass G-type receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ7] 1951 CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2 CELSR3 gene dto:DTO_02200067 A cysteinyl leukotriene receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y271] 10800 CYSLTR1 CYSLT1 CYSLTR1 gene dto:DTO_02200068 A cysteinyl leukotriene receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS75] 57105 CYSLTR2 CYSLT2 CYSLT2R CYSLTR2 gene dto:DTO_02200069 A chemokine receptor-like protein CMKLR1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99788] 1240 CMKLR1 CHEMR23 DEZ CMKLR1 gene dto:DTO_02200070 A cannabinoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21554] 1268 CNR1 CNR CNR1 gene dto:DTO_02200071 A cannabinoid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34972] 1269 CNR2 CB2A CB2B CNR2 gene dto:DTO_02200072 A corticotropin-releasing factor receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34998] 1394 CRHR1 CRFR CRFR1 CRHR CRHR1 gene dto:DTO_02200073 A corticotropin-releasing factor receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13324] 1395 CRHR2 CRF2R CRH2R CRHR2 gene dto:DTO_02200074 A CX3C chemokine receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49238] 1524 CX3CR1 CMKBRL1 GPR13 CX3CR1 gene dto:DTO_02200075 A C-X-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25024] 3577 CXCR1 CMKAR1 IL8RA CXCR1 gene dto:DTO_02200076 A C-X-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25025] 3579 CXCR2 IL8RB CXCR2 gene dto:DTO_02200077 A C-X-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49682] 2833 CXCR3 GPR9 CXCR3 gene dto:DTO_02200078 A C-X-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P61073] 7852 CXCR4 CXCR4 gene dto:DTO_02200079 A C-X-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32302] 643 CXCR5 BLR1 MDR15 CXCR5 gene dto:DTO_02200080 A C-X-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_14906] 10663 CXCR6 BONZO STRL33 TYMSTR CXCR6 gene dto:DTO_02200081 A D(1A) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21728] 1812 DRD1 DRD1 gene dto:DTO_02200082 A D(2) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P14416] 1813 DRD2 DRD2 gene dto:DTO_02200083 A D(3) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35462] 1814 DRD3 DRD3 gene dto:DTO_02200084 A D(4) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21917] 1815 DRD4 DRD4 gene dto:DTO_02200085 A D(1B) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21918] 1816 DRD5 DRD1B DRD1L2 DRD5 gene dto:DTO_02200086 An endothelin-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25101] 1909 EDNRA ETA ETRA EDNRA gene dto:DTO_02200087 An endothelin B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24530] 1910 EDNRB ETRB EDNRB gene dto:DTO_02200088 An EGF, latrophilin and seven transmembrane domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBW9] 64123 ELTD1 ETL ADGRL4 gene dto:DTO_02200089 An EGF-like module-containing mucin-like hormone receptor-like 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14246] 2015 EMR1 TM7LN3 ADGRE1 gene dto:DTO_02200090 An EGF-like module-containing mucin-like hormone receptor-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHX3] 30817 EMR2 ADGRE2 gene dto:DTO_02200091 An EGF-like module-containing mucin-like hormone receptor-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BY15] 84658 EMR3 EMR3 gene dto:DTO_02200092 326342 EMR4P EMR4 GPR127 PGR16 EMR4P gene dto:DTO_02200093 A prosaposin receptor GPR37L1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60883] 9283 GPR37L1 ETBRLP2 GPR37L1 gene dto:DTO_02200094 A free fatty acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14842] 2864 FFAR1 GPR40 FFAR1 gene dto:DTO_02200095 A free fatty acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15552] 2867 FFAR2 FFA2 GPCR43 GPR43 FFAR2 gene dto:DTO_02200096 A free fatty acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14843] 2865 FFAR3 GPR41 FFAR3 gene dto:DTO_02200097 A free fatty acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5NUL3] 338557 FFAR4 GPR120 GPR129 O3FAR1 PGR4 FFAR4 gene dto:DTO_02200098 An fMet-Leu-Phe receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21462] 2357 FPR1 FPR1 gene dto:DTO_02200099 An N-formyl peptide receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25090] 2358 FPR2 FPRH1 FPRL1 LXA4R FPR2 gene dto:DTO_02200100 An N-formyl peptide receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25089] 2359 FPR3 FPRH1 FPRL2 FPR3 gene dto:DTO_02200101 A follitropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P23945] 2492 FSHR LGR1 FSHR gene dto:DTO_02200102 A frizzled-10 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULW2] 11211 FZD10 FZD10 gene dto:DTO_02200103 A frizzled-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UP38] 8321 FZD1 FZD1 gene dto:DTO_02200104 A frizzled-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14332] 2535 FZD2 FZD2 gene dto:DTO_02200105 A frizzled-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPG1] 7976 FZD3 FZD3 gene dto:DTO_02200106 A frizzled-4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULV1] 8322 FZD4 FZD4 gene dto:DTO_02200107 A frizzled-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13467] 7855 FZD5 C2orf31 FZD5 gene dto:DTO_02200108 A frizzled-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60353] 8323 FZD6 FZD6 gene dto:DTO_02200109 A frizzled-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75084] 8324 FZD7 FZD7 gene dto:DTO_02200110 A frizzled-8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H461] 8325 FZD8 FZD8 gene dto:DTO_02200111 A frizzled-9 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00144] 8326 FZD9 FZD3 FZD9 gene dto:DTO_02200112 An integral membrane protein GPR137 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96N19] 56834 GPR137 C11orf4 GPR137A TM7SF1L1 GPR137 gene dto:DTO_02200113 A gamma-aminobutyric acid type B receptor subunit 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBS5] 2550 GABBR1 GPRC3A GABBR1 gene dto:DTO_02200114 A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75899] 9568 GABBR2 GPR51 GPRC3B GABBR2 gene dto:DTO_02200115 A galanin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47211] 2587 GALR1 GALNR GALNR1 GALR1 gene dto:DTO_02200116 A galanin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43603] 8811 GALR2 GALNR2 GALR2 gene dto:DTO_02200117 A galanin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60755] 8484 GALR3 GALNR3 GALR3 gene dto:DTO_02200118 A cholecystokinin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32239] 887 CCKBR CCKRB CCKBR gene dto:DTO_02200119 A growth hormone-releasing hormone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02643] 2692 GHRHR GHRHR gene dto:DTO_02200120 A growth hormone secretagogue receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92847] 2693 GHSR GHSR gene dto:DTO_02200121 A gastric inhibitory polypeptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48546] 2696 GIPR GIPR gene dto:DTO_02200122 A glucagon-like peptide 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43220] 2740 GLP1R GLP1R gene dto:DTO_02200123 A glucagon-like peptide 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95838] 9340 GLP2R GLP2R gene dto:DTO_02200124 A glucagon receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47871] 2642 GCGR GCGR gene dto:DTO_02200125 A gonadotropin-releasing hormone I receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30968] 2798 GNRHR GRHR GNRHR gene dto:DTO_02200126 A gonadotropin-releasing hormone II receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P88] GNRHR2 GNRHR2 gene dto:DTO_02200127 A G-protein coupled receptor 101 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P66] 83550 GPR101 GPR101 gene dto:DTO_02200128 A protein GPR107 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VW38] 57720 GPR107 KIAA1624 LUSTR1 GPR107 gene dto:DTO_02200129 A G-protein coupled receptor 110 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T601] 266977 GPR110 PGR19 GPR110 gene dto:DTO_02200130 A G-protein coupled receptor 111 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF7] 222611 GPR111 PGR20 GPR111 gene dto:DTO_02200131 A G-protein coupled receptor 112 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF6] 139378 GPR112 GPR112 gene dto:DTO_02200132 A G-protein coupled receptor 113 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF5] 165082 GPR113 PGR23 GPR113 gene dto:DTO_02200133 A G-protein coupled receptor 114 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF4] 221188 GPR114 PGR27 GPR114 gene dto:DTO_02200134 A G-protein coupled receptor 115 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF3] 221393 GPR115 PGR18 GPR115 gene dto:DTO_02200135 A G-protein coupled receptor 116 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF2] 221395 GPR116 KIAA0758 GPR116 gene dto:DTO_02200136 A glucose-dependent insulinotropic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV5] 139760 GPR119 GPR119 gene dto:DTO_02200137 A G-protein coupled receptor 123 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SQ6] 84435 GPR123 KIAA1828 ADGRA1 gene dto:DTO_02200138 A G-protein coupled receptor 124 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PE1] 25960 GPR124 KIAA1531 TEM5 GPR124 gene dto:DTO_02200139 A G-protein coupled receptor 125 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWK6] 166647 GPR125 ADGRA3 gene dto:DTO_02200140 A G-protein coupled receptor 126 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86SQ4] 57211 GPR126 DREG VIGR GPR126 gene dto:DTO_02200141 A G-protein coupled receptor 128 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96K78] 84873 GPR128 GPR128 gene dto:DTO_02200142 A G-protein coupled receptor 132 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UNW8] 29933 GPR132 G2A GPR132 gene dto:DTO_02200143 A G-protein coupled receptor 133 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QNK2] 283383 GPR133 PGR25 GPR133 gene dto:DTO_02200144 A G-protein coupled receptor 135 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IZ08] 64582 GPR135 GPR135 gene dto:DTO_02200145 A G-protein coupled receptor 139 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6DWJ6] 124274 GPR139 GPRG1 PGR3 GPR139 gene dto:DTO_02200146 A G-protein coupled receptor 141 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z602] 353345 GPR141 PGR13 GPR141 gene dto:DTO_02200147 A G-protein coupled receptor 142 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z601] 350383 GPR142 PGR2 GPR142 gene dto:DTO_02200148 A G-protein coupled receptor 143 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51810] 4935 GPR143 OA1 GPR143 gene dto:DTO_02200149 A G-protein coupled receptor 144 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z7M1] 347088 GPR144 PGR24 GPR144 gene dto:DTO_02200150 A G-protein coupled receptor 146 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96CH1] 115330 GPR146 PGR8 GPR146 gene dto:DTO_02200151 A G-protein coupled receptor 148 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV2] 344561 GPR148 BTR PGR6 GPR148 gene dto:DTO_02200152 A G-protein coupled receptor 149 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SP6] 344758 GPR149 PGR10 GPR149 gene dto:DTO_02200153 A G-protein coupled receptor 150 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NGU9] 285601 GPR150 GPR150 gene dto:DTO_02200154 A G-protein coupled receptor 151 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV0] 134391 GPR151 PGR7 GPR151 gene dto:DTO_02200155 A G-protein coupled receptor 152 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDT2] 390212 GPR152 PGR5 GPR152 gene dto:DTO_02200156 A G-protein coupled receptor 153 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6NV75] 387509 GPR153 PGR1 GPR153 gene dto:DTO_02200157 A G-protein coupled receptor 156 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFN8] 165829 GPR156 GABABL PGR28 GPR156 gene dto:DTO_02200158 A G-protein coupled receptor 157 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5UAW9] 80045 GPR157 GPR157 gene dto:DTO_02200159 A G-protein coupled receptor 158 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T848] 57512 GPR158 KIAA1136 GPR158 gene dto:DTO_02200160 A G-protein coupled receptor 160 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UJ42] 26996 GPR160 GPCR150 GPR160 gene dto:DTO_02200161 A G-protein coupled receptor 161 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8N6U8] 23432 GPR161 GPR161 gene dto:DTO_02200162 A G-protein coupled receptor 162 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16538] 27239 GPR162 GRCA GPR162 gene dto:DTO_02200163 A G-protein coupled receptor 171 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14626] 29909 GPR171 H963 GPR171 gene dto:DTO_02200164 A G-protein coupled receptor 173 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS66] 54328 GPR173 SREB3 GPR173 gene dto:DTO_02200165 A G-protein coupled receptor 174 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC1] 84636 GPR174 GPR174 gene dto:DTO_02200166 A G-protein coupled receptor 176 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14439] 11245 GPR176 GPR176 gene dto:DTO_02200167 A G-protein coupled receptor 179 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PRD1] 440435 GPR179 GPR158L GPR158L1 GPR179 gene dto:DTO_02200168 A G-protein coupled receptor 182 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15218] 11318 GPR182 ADMR GPR182 gene dto:DTO_02200169 A G-protein coupled receptor 183 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32249] 1880 GPR183 EBI2 GPR183 gene dto:DTO_02200170 A G-protein coupled bile acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU6] 151306 GPBAR1 TGR5 GPBAR1 gene dto:DTO_02200171 2855 GPR32P1 GPR32P1 gene dto:DTO_02200172 A G-protein coupled receptor family C group 5 member B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZH0] 51704 GPRC5B RAIG2 GPRC5B gene dto:DTO_02200173 A G-protein coupled receptor family C group 5 member C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ84] 55890 GPRC5C RAIG3 GPRC5C gene dto:DTO_02200174 A G-protein coupled receptor family C group 5 member D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZD1] 55507 GPRC5D GPRC5D gene dto:DTO_02200175 A G-protein coupled receptor family C group 6 member A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T6X5] 222545 GPRC6A GPRC6A gene dto:DTO_02200176 A G-protein coupled estrogen receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99527] 2852 GPER1 CEPR CMKRL2 DRY12 GPER GPR30 GPER1 gene dto:DTO_02200177 A G-protein coupled receptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47775] 2835 GPR12 GPR12 gene dto:DTO_02200178 A G-protein coupled receptor 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49685] 2838 GPR15 GPR15 gene dto:DTO_02200179 A uracil nucleotide/cysteinyl leukotriene receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13304] 2840 GPR17 GPR17 gene dto:DTO_02200180 An N-arachidonyl glycine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14330] 2841 GPR18 GPCRW GPR18 gene dto:DTO_02200181 A G-protein coupled receptor 19 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15760] 2842 GPR19 GPR19 gene dto:DTO_02200182 A G-protein coupled receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46091] 2825 GPR1 GPR1 gene dto:DTO_02200183 A G-protein coupled receptor 20 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99678] 2843 GPR20 GPR20 gene dto:DTO_02200184 A G-protein coupled receptor 21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99679] 2844 GPR21 GPR21 gene dto:DTO_02200185 A G-protein coupled receptor 22 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99680] 2845 GPR22 GPR22 gene dto:DTO_02200186 A G-protein coupled receptor 25 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00155] 2848 GPR25 GPR25 gene dto:DTO_02200187 A G-protein coupled receptor 26 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NDV2] 2849 GPR26 GPR26 gene dto:DTO_02200188 A G-protein coupled receptor 27 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS67] 2850 GPR27 SREB1 GPR27 gene dto:DTO_02200189 A 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00270] 2853 GPR31 GPR31 gene dto:DTO_02200190 A G-protein coupled receptor 32 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75388] 2854 GPR32 GPR32 gene dto:DTO_02200191 A G-protein coupled receptor 33 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q49SQ1] 2856 GPR33 GPR33 gene dto:DTO_02200192 A G-protein coupled receptor 34 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UPC5] 2857 GPR34 GPR34 gene dto:DTO_02200193 A G-protein coupled receptor 35 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HC97] 2859 GPR35 GPR35 gene dto:DTO_02200194 A G-protein coupled receptor 37 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15354] 2861 GPR37 GPR37 gene dto:DTO_02200195 A G-protein coupled receptor 39 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43194] 2863 GPR39 GPR39 gene dto:DTO_02200196 A G-protein coupled receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46089] 2827 GPR3 ACCA GPR3 gene dto:DTO_02200197 A G-protein coupled receptor 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15529] 2866 GPR42 GPR42P GPR42 gene dto:DTO_02200198 A G-protein coupled receptor 45 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y3] 11250 GPR45 GPR45 gene dto:DTO_02200199 A G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46093] 2828 GPR4 GPR19 GPR4 gene dto:DTO_02200200 A G-protein coupled receptor 52 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T5] 9293 GPR52 GPR52 gene dto:DTO_02200201 A G-protein coupled receptor 55 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T6] 9290 GPR55 GPR55 gene dto:DTO_02200202 A G-protein coupled receptor 56 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y653] 9289 GPR56 TM7LN4 TM7XN1 GPR56 gene dto:DTO_02200203 A G-protein coupled receptor 61 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ8] 83873 GPR61 BALGR GPR61 gene dto:DTO_02200204 A G-protein coupled receptor 62 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ7] 118442 GPR62 GPR62 gene dto:DTO_02200205 A G-protein coupled receptor 63 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ6] 81491 GPR63 PSP24B GPR63 gene dto:DTO_02200206 A G-protein coupled receptor 64 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZP9] 10149 GPR64 HE6 TM7LN2 GPR64 gene dto:DTO_02200207 A G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46095] 2830 GPR6 GPR6 gene dto:DTO_02200208 A G-protein coupled receptor 75 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95800] 10936 GPR75 GPR75 gene dto:DTO_02200209 A G-protein coupled receptor 78 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P69] 27201 GPR78 GPR78 gene dto:DTO_02200210 A G-protein coupled receptor 82 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P67] 27197 GPR82 GPR82 gene dto:DTO_02200211 A G-protein coupled receptor 83 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NYM4] 10888 GPR83 GPR72 KIAA1540 GPR83 gene dto:DTO_02200212 A G-protein coupled receptor 84 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NQS5] 53831 GPR84 EX33 GPR84 gene dto:DTO_02200213 A G-protein coupled receptor 85 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P60893] 54329 GPR85 SREB2 GPR85 gene dto:DTO_02200214 A G-protein coupled receptor 87 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BY21] 53836 GPR87 GPR95 GPR87 gene dto:DTO_02200215 A G-protein coupled receptor 88 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZN0] 54112 GPR88 STRG GPR88 gene dto:DTO_02200216 A G-protein coupled receptor 97 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Y34] 222487 GPR97 PGR26 GPR97 gene dto:DTO_02200217 A G-protein coupled receptor 98 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXG9] 84059 GPR98 KIAA0686 KIAA1943 MASS1 VLGR1 GPR98 gene dto:DTO_02200218 A metabotropic glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13255] 2911 GRM1 GPRC1A MGLUR1 GRM1 gene dto:DTO_02200219 A metabotropic glutamate receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14416] 2912 GRM2 GPRC1B MGLUR2 GRM2 gene dto:DTO_02200220 A metabotropic glutamate receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14832] 2913 GRM3 GPRC1C MGLUR3 GRM3 gene dto:DTO_02200221 A metabotropic glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14833] 2914 GRM4 GPRC1D MGLUR4 GRM4 gene dto:DTO_02200222 A metabotropic glutamate receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41594] 2915 GRM5 GPRC1E MGLUR5 GRM5 gene dto:DTO_02200223 A metabotropic glutamate receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15303] 2916 GRM6 GPRC1F MGLUR6 GRM6 gene dto:DTO_02200224 A metabotropic glutamate receptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14831] 2917 GRM7 GPRC1G MGLUR7 GRM7 gene dto:DTO_02200225 A metabotropic glutamate receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00222] 2918 GRM8 GPRC1H MGLUR8 GRM8 gene dto:DTO_02200226 A gastrin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30550] 2925 GRPR GRPR gene dto:DTO_02200227 A hydroxycarboxylic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC0] 27198 HCAR1 GPR104 GPR81 HCA1 HCAR1 gene dto:DTO_02200228 A hydroxycarboxylic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS4] 338442 HCAR2 GPR109A HCA2 HM74A NIACR1 HCAR2 gene dto:DTO_02200229 A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49019] 8843 HCAR3 GPR109B HCA3 HM74B NIACR2 HCAR3 gene dto:DTO_02200230 A histamine H1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35367] 3269 HRH1 HRH1 gene dto:DTO_02200231 A histamine H2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25021] 3274 HRH2 HRH2 gene dto:DTO_02200232 A histamine H3 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5N1] 11255 HRH3 GPCR97 HRH3 gene dto:DTO_02200233 An H4 histamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H3N8] 59340 HRH4 GPCR105 HRH4 gene dto:DTO_02200234 A KiSS-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969F8] 84634 KISS1R AXOR12 GPR54 KISS1R gene dto:DTO_02200235 A leucine-rich repeat-containing G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXB1] 55366 LGR4 GPR48 LGR4 gene dto:DTO_02200236 A leucine-rich repeat-containing G-protein coupled receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75473] 8549 LGR5 GPR49 GPR67 LGR5 gene dto:DTO_02200237 A leucine-rich repeat-containing G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX8] 59352 LGR6 LGR6 gene dto:DTO_02200238 A lysophosphatidic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92633] 1902 LPAR1 EDG2 LPA1 LPAR1 gene dto:DTO_02200239 A lysophosphatidic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBW0] 9170 LPAR2 EDG4 LPA2 LPAR2 gene dto:DTO_02200240 A lysophosphatidic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UBY5] 23566 LPAR3 EDG7 LPA3 LPAR3 gene dto:DTO_02200241 A lysophosphatidic acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99677] 2846 LPAR4 GPR23 LPA4 P2RY9 LPAR4 gene dto:DTO_02200242 A lysophosphatidic acid receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1C0] 57121 LPAR5 GPR92 GPR93 LPAR5 gene dto:DTO_02200243 An oleoyl-L-alpha-lysophosphatidic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43657] 10161 LPAR6 P2RY5 LPAR6 gene dto:DTO_02200244 A latrophilin-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O94910] 22859 LPHN1 KIAA0821 LEC2 LPHN1 gene dto:DTO_02200245 A latrophilin-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O95490] 23266 LPHN2 KIAA0786 LEC1 LPHH1 LPHN2 gene dto:DTO_02200246 A latrophilin-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HAR2] 23284 LPHN3 KIAA0768 LEC3 LPHN3 gene dto:DTO_02200247 A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P22888] 3973 LHCGR LCGR LGR2 LHRHR LHCGR gene dto:DTO_02200248 A leukotriene B4 receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15722] 1241 LTB4R BLT BLT1 BLTR CMKRL1 GPR16 P2RY7 LTB4R gene dto:DTO_02200249 A leukotriene B4 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC1] 56413 LTB4R2 BLT2R BLTR2 LTB4R2 gene dto:DTO_02200250 A mas-related G-protein coupled receptor MRG that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35410] 116511 MAS1L MRG MAS1L gene dto:DTO_02200251 A G-protein coupled receptor MAS that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04201] 4142 MAS1 MAS MAS1 gene dto:DTO_02200252 A melanocortin receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41968] 4159 MC3R MC3R gene dto:DTO_02200253 A melanocortin receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32245] 4160 MC4R MC4R gene dto:DTO_02200254 A melanocortin receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P33032] 4161 MC5R MC5R gene dto:DTO_02200255 A melanin-concentrating hormone receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99705] 2847 MCHR1 GPR24 SLC1 MCHR1 gene dto:DTO_02200256 A melanin-concentrating hormone receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969V1] 84539 MCHR2 GPR145 SLT MCHR2 gene dto:DTO_02200257 A mas-related G-protein coupled receptor D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS7] 116512 MRGPRD MRGD MRGPRD gene dto:DTO_02200258 A mas-related G-protein coupled receptor E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM8] 116534 MRGPRE GPR167 MRGE MRGPRE gene dto:DTO_02200259 A mas-related G-protein coupled receptor F that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96AM1] 116535 MRGPRF GPR140 GPR168 MRGF MRGPRF gene dto:DTO_02200260 A mas-related G-protein coupled receptor G that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM5] 386746 MRGPRG GPR169 MRGG MRGPRG gene dto:DTO_02200261 A mas-related G-protein coupled receptor X1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB2] 259249 MRGPRX1 MRGX1 SNSR3 SNSR4 MRGPRX1 gene dto:DTO_02200262 A mas-related G-protein coupled receptor X2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB1] 117194 MRGPRX2 MRGX2 MRGPRX2 gene dto:DTO_02200263 A mas-related G-protein coupled receptor X3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB0] 117195 MRGPRX3 MRGX3 SNSR1 SNSR2 MRGPRX3 gene dto:DTO_02200264 A mas-related G-protein coupled receptor X4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LA9] 117196 MRGPRX4 MRGX4 SNSR5 SNSR6 MRGPRX4 gene dto:DTO_02200265 A melanocyte-stimulating hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01726] 4157 MC1R MSHR MC1R gene dto:DTO_02200266 A motilin receptor that is encoded in the genome of human. [Reactome:REACT_21601] 2862 MLNR GPR38 MTLR MTLR1 MLNR gene dto:DTO_02200267 A melatonin receptor type 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48039] 4543 MTNR1A MTNR1A gene dto:DTO_02200268 A melatonin receptor type 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49286] 4544 MTNR1B MTNR1B gene dto:DTO_02200269 A melatonin-related receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13585] 9248 GPR50 GPR50 gene dto:DTO_02200270 A substance-P receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25103] 6869 TACR1 NK1R TAC1R TACR1 gene dto:DTO_02200271 A substance-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21452] 6865 TACR2 NK2R NKNAR TAC2R TACR2 gene dto:DTO_02200272 A neuromedin-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29371] 6870 TACR3 NK3R TAC3R TACR3 gene dto:DTO_02200273 A neuromedin-B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28336] 4829 NMBR NMBR gene dto:DTO_02200274 A neuromedin-U receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB89] 10316 NMUR1 GPR66 NMUR1 gene dto:DTO_02200275 A neuromedin-U receptor 2 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_27011] 56923 NMUR2 NMU2R TGR1 NMUR2 gene dto:DTO_02200276 A neuropeptides B/W receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48145] 2831 NPBWR1 GPR7 NPBWR1 gene dto:DTO_02200277 A neuropeptides B/W receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48146] 2832 NPBWR2 GPR8 NPBWR2 gene dto:DTO_02200278 A neuropeptide FF receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZQ6] 64106 NPFFR1 GPR147 NPFF1 NPFFR1 gene dto:DTO_02200279 A neuropeptide FF receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5X5] 10886 NPFFR2 GPR74 NPFF2 NPGPR NPFFR2 gene dto:DTO_02200280 A neuropeptide S receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6W5P4] 387129 NPSR1 GPR154 GPRA PGR14 NPSR1 gene dto:DTO_02200281 A neuropeptide Y receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25929] 4886 NPY1R NPYR NPYY1 NPY1R gene dto:DTO_02200282 A neuropeptide Y receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49146] 4887 NPY2R NPY2R gene dto:DTO_02200283 A neuropeptide Y receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50391] 100996758 5540 NPY4R PPYR1 NPY4R gene dto:DTO_02200284 A neuropeptide Y receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15761] 4889 NPY5R NPYR5 NPY5R gene dto:DTO_02200286 A neurotensin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30989] 4923 NTSR1 NTRR NTSR1 gene dto:DTO_02200287 A neurotensin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95665] 23620 NTSR2 NTSR2 gene dto:DTO_02200288 An olfactory receptor 10A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H208] 341276 OR10A2 OR10A2P OR10A2 gene dto:DTO_02200289 An olfactory receptor 10A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58181] 26496 OR10A3 OR10A3 gene dto:DTO_02200290 An olfactory receptor 10A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H209] 283297 OR10A4 OR10A4P OR10A4 gene dto:DTO_02200291 An olfactory receptor 10A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H207] 144124 OR10A5 OR10A1 OR10A5 gene dto:DTO_02200292 An olfactory receptor 10A6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH74] 390093 OR10A6 OR10A6 gene dto:DTO_02200293 An olfactory receptor 10A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE5] 121364 OR10A7 OR10A7 gene dto:DTO_02200294 An olfactory receptor 10AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH08] 392133 OR10AC1 OR10AC1P OR10AC1 gene dto:DTO_02200295 An olfactory receptor 10AD1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE0] 121275 OR10AD1 OR10AD1P OR10AD1 gene dto:DTO_02200296 An olfactory receptor 10AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH19] 282770 OR10AG1 OR10AG1 gene dto:DTO_02200297 An olfactory receptor 10C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KK4] 442194 OR10C1 OR10C2 OR10C1 gene dto:DTO_02200298 An olfactory receptor 958 that is encoded in the genome of human. [OMA:HUMAN05487, PRO:DNx] 26497 OR10D3 OR10D3P OR10D3 gene dto:DTO_02200299 390266 OR10D4P OR10D4 OR10D4P gene dto:DTO_02200300 An olfactory receptor 10G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC3] 26534 OR10G2 OR10G2 gene dto:DTO_02200301 An olfactory receptor 10G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC4] 26533 OR10G3 OR10G3 gene dto:DTO_02200302 An olfactory receptor 10G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN3] 390264 OR10G4 OR10G4 gene dto:DTO_02200303 An olfactory receptor 10G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH81] 79490 OR10G6 OR10G6P OR10G6 gene dto:DTO_02200304 An olfactory receptor 10G7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN6] 390265 OR10G7 OR10G7 gene dto:DTO_02200305 An olfactory receptor 10G8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN5] 219869 OR10G8 OR10G8 gene dto:DTO_02200306 An olfactory receptor 10G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN4] 219870 OR10G9 OR10G10P OR10G9 gene dto:DTO_02200307 An olfactory receptor 10H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4A9] 26539 OR10H1 OR10H1 gene dto:DTO_02200308 An olfactory receptor 10H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60403] 26538 OR10H2 OR10H2 gene dto:DTO_02200309 An olfactory receptor 10H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60404] 26532 OR10H3 OR10H3 gene dto:DTO_02200310 An olfactory receptor 10H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA5] 126541 OR10H4 OR10H4 gene dto:DTO_02200311 An olfactory receptor 10H5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA6] 284433 OR10H5 OR10H5 gene dto:DTO_02200312 An olfactory receptor 10J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30954] 26476 OR10J1 OR10J1 gene dto:DTO_02200313 An olfactory receptor 10J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JRS4] 441911 OR10J3 OR10J3P OR10J3 gene dto:DTO_02200314 An olfactory receptor 10J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C629] 391121 OR10J4 OR10J4P OR10J4 gene dto:DTO_02200315 An olfactory receptor 10J5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC4] 127385 OR10J5 OR10J5 gene dto:DTO_02200316 401973 OR10J6P OR10J6 OR10J6P gene dto:DTO_02200317 An olfactory receptor 10K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX5] 391109 OR10K1 OR10K1 gene dto:DTO_02200318 An olfactory receptor 10K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF99] 391107 OR10K2 OR10K2 gene dto:DTO_02200319 An olfactory receptor 10P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE3] 121130 OR10P1 OR10P1P OR10P2P OR10P3P OR10P1 gene dto:DTO_02200320 An olfactory receptor 10Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ4] 219960 OR10Q1 OR10Q1 gene dto:DTO_02200321 An olfactory receptor 10R2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX6] 343406 OR10R2 OR10R2 gene dto:DTO_02200322 An olfactory receptor 10S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN2] 219873 OR10S1 OR10S1 gene dto:DTO_02200323 An olfactory receptor 10T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX3] 128360 OR10T2 OR10T2 gene dto:DTO_02200324 An olfactory receptor 10V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI7] 390201 OR10V1 OR10V1 gene dto:DTO_02200325 An olfactory receptor 10W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF6] 81341 OR10W1 OR10W1P OR10W1 gene dto:DTO_02200326 An olfactory receptor 10X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY0] 128367 OR10X1 OR10X1P OR10X1 gene dto:DTO_02200327 An olfactory receptor 10Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY1] 128368 OR10Z1 OR10Z1 gene dto:DTO_02200328 An olfactory receptor 11A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK7] 26531 OR11A1 OR11A2 OR11A1 gene dto:DTO_02200329 An olfactory receptor 11G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC1] 390439 OR11G2 OR11G2 gene dto:DTO_02200330 An olfactory receptor 11H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG94] 81061 OR11H1 OR11H1 gene dto:DTO_02200331 An olfactory receptor 11H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH07] 79334 OR11H2 C14orf15 OR11H2P OR11H2 gene dto:DTO_02200332 An olfactory receptor 11H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC9] 390442 OR11H4 OR11H4 gene dto:DTO_02200333 An olfactory receptor 11H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC7] 122748 OR11H6 OR11H6 gene dto:DTO_02200334 An olfactory receptor 11H7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC8] 390441 OR11H7 OR11H7P OR11H7 gene dto:DTO_02200335 An olfactory receptor 11H12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:B2RN74] 440153 OR11H12 OR11H12 gene dto:DTO_02200336 An olfactory receptor 11L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX0] 391189 OR11L1 OR11L1 gene dto:DTO_02200337 An olfactory receptor 12D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58182] 26529 OR12D2 OR12D2 gene dto:DTO_02200338 An olfactory receptor 12D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF7] 81797 OR12D3 OR12D3 gene dto:DTO_02200339 An olfactory receptor 13A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR1] 79290 OR13A1 OR13A1 gene dto:DTO_02200340 An olfactory receptor 13C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS9] 392376 OR13C2 OR13C2 gene dto:DTO_02200341 An olfactory receptor 13C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS6] 138803 OR13C3 OR13C3 gene dto:DTO_02200342 An olfactory receptor 13C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS5] 138804 OR13C4 OR13C4 gene dto:DTO_02200343 An olfactory receptor 13C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS8] 138799 OR13C5 OR13C5 gene dto:DTO_02200344 An olfactory receptor 13C8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS7] 138802 OR13C8 OR13C8 gene dto:DTO_02200345 An olfactory receptor 13C9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT0] 286362 OR13C9 OR13C9 gene dto:DTO_02200346 An olfactory receptor 13D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV5] 286365 OR13D1 OR13D1 gene dto:DTO_02200347 An olfactory receptor 13F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS4] 138805 OR13F1 OR13F1 gene dto:DTO_02200348 An olfactory receptor 13G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ3] 441933 OR13G1 OR13G1 gene dto:DTO_02200349 An olfactory receptor 13H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG92] 347468 OR13H1 OR13H1 gene dto:DTO_02200350 An olfactory receptor 13J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT2] 392309 OR13J1 OR13J1 gene dto:DTO_02200351 An olfactory receptor 14A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R54] 388761 OR14A2 OR5AX1 OR5AX1P OR14A2 gene dto:DTO_02200352 An olfactory receptor 14A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC5] 284532 OR14A16 OR5AT1 OR14A16 gene dto:DTO_02200353 An olfactory receptor 14C36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC7] 127066 OR14C36 OR5BF1 OR14C36 gene dto:DTO_02200354 An olfactory receptor 14I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6ND48] 401994 OR14I1 OR5BU1 OR5BU1P OR14I1 gene dto:DTO_02200355 An olfactory receptor 14J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF5] 442191 OR14J1 OR5U1 OR14J1 gene dto:DTO_02200356 An olfactory receptor 14K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ2] 343170 OR14K1 OR5AY1 OR14K1 gene dto:DTO_02200357 127617 OR14L1P OR5AV1P OR14L1P gene dto:DTO_02200358 An olfactory receptor 2A12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT7] 346525 OR2A12 OR2A12P OR2A12 gene dto:DTO_02200359 An olfactory receptor 2A14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R47] 135941 OR2A14 OR2A14P OR2A6 OR2A14 gene dto:DTO_02200360 An olfactory receptor 2A25 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A4D2G3] 392138 OR2A25 OR2A25P OR2A27 OR2A25 gene dto:DTO_02200361 An olfactory receptor 2AE1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA4] 81392 OR2AE1 OR2AE2 OR2AE1 gene dto:DTO_02200362 An olfactory receptor 2AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H205] 144125 OR2AG1 OR2AG3 OR2AG1 gene dto:DTO_02200363 An olfactory receptor 2AG2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM03] 338755 OR2AG2 OR2AG2P OR2AG2 gene dto:DTO_02200364 An olfactory receptor 2AJ1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ0] 127608 OR2AJ1 OR2AJ1P OR2AJ1 gene dto:DTO_02200365 An olfactory receptor 2AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG84] 391191 OR2AK2 OR2AK1P OR2AK2 gene dto:DTO_02200366 An olfactory receptor 2AP1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE2] 121129 OR2AP1 OR2AP1P OR2AP1 gene dto:DTO_02200367 An olfactory receptor 2AT4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NND4] 341152 OR2AT4 OR2AT4 gene dto:DTO_02200368 An olfactory receptor 2T10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ9] 127069 OR2T10 OR2T10 gene dto:DTO_02200369 An olfactory receptor 2T11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH01] 127077 OR2T11 OR2T11 gene dto:DTO_02200370 An olfactory receptor 2T12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG77] 127064 OR2T12 OR2T12 gene dto:DTO_02200371 An olfactory receptor 2T27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH04] 403239 OR2T27 OR2T27 gene dto:DTO_02200372 An olfactory receptor 2T29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH02] 343563 OR2T29 OR2T29 gene dto:DTO_02200373 An olfactory receptor 2T33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG76] 391195 OR2T33 OR2T33 gene dto:DTO_02200374 An olfactory receptor 2T34 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX1] 127068 OR2T34 OR2T34 gene dto:DTO_02200375 An olfactory receptor 2T35 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX2] 403244 OR2T35 OR2T35 gene dto:DTO_02200376 An olfactory receptor 4A15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL6] 81328 OR4A15 OR4A15 gene dto:DTO_02200377 An olfactory receptor 4A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH70] 81327 OR4A16 OR4A16 gene dto:DTO_02200378 An olfactory receptor 4A47 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF82] 403253 OR4A47 OR4A47 gene dto:DTO_02200379 An olfactory receptor 4C45 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMZ5] 403257 OR4C45 OR4C45 gene dto:DTO_02200380 An olfactory receptor 4C46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHA9] 119749 OR4C46 OR4C46 gene dto:DTO_02200381 An olfactory receptor 4F15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB8] 390649 OR4F15 OR4F15 gene dto:DTO_02200382 An olfactory receptor 4F17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA8] 81099 OR4F17 OR4F11P OR4F18 OR4F19 OR4F17 gene dto:DTO_02200383 An olfactory receptor 4F21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95013] 441308 OR4F21 OR4F21P OR4F21 gene dto:DTO_02200384 An olfactory receptor 51A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ7] 401667 OR51A2 OR51A2 gene dto:DTO_02200385 An olfactory receptor 51A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ6] 401666 OR51A4 OR51A4 gene dto:DTO_02200386 An olfactory receptor 51A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH64] 119687 OR51A7 OR51A7 gene dto:DTO_02200387 An olfactory receptor 51B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P1] 79345 OR51B2 OR51B1P OR51B2 gene dto:DTO_02200388 An olfactory receptor 51B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P0] 79339 OR51B4 OR51B4 gene dto:DTO_02200389 An olfactory receptor 51B5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H339] 282763 OR51B5 OR51B5 gene dto:DTO_02200390 An olfactory receptor 51B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H340] 390058 OR51B6 OR51B6 gene dto:DTO_02200391 An olfactory receptor 51D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF3] 390038 OR51D1 OR51D1 gene dto:DTO_02200392 An olfactory receptor 51E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCB6] 143503 OR51E1 GPR164 OR51E1P OR52A3P POGR PSGR2 OR51E1 gene dto:DTO_02200393 An olfactory receptor 51E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H255] 81285 OR51E2 PSGR OR51E2 gene dto:DTO_02200394 An olfactory receptor 51F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NGY5] 256892 OR51F1 OR51F1P OR51F1 gene dto:DTO_02200395 An olfactory receptor 51F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH61] 119694 OR51F2 OR51F2 gene dto:DTO_02200396 An olfactory receptor 51G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK1] 79324 OR51G1 OR51G3P OR51G1 gene dto:DTO_02200397 An olfactory receptor 51G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK0] 81282 OR51G2 OR51G2 gene dto:DTO_02200398 401663 OR51H1P OR51H1 OR51H1P gene dto:DTO_02200399 An olfactory receptor 51I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H343] 390063 OR51I1 OR51I1 gene dto:DTO_02200400 An olfactory receptor 51I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H344] 390064 OR51I2 OR51I2 gene dto:DTO_02200401 An olfactory receptor 51J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H342] 79470 OR51J1 OR51J1P OR51J2 OR51J1 gene dto:DTO_02200402 An olfactory receptor 51L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ5] 119682 OR51L1 OR51L1 gene dto:DTO_02200403 An olfactory receptor 51M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H341] 390059 OR51M1 OR51M1 gene dto:DTO_02200404 An olfactory receptor 51Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH59] 390061 OR51Q1 OR51Q1 gene dto:DTO_02200405 An olfactory receptor 51S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ8] 119692 OR51S1 OR51S1 gene dto:DTO_02200406 An olfactory receptor 51T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ9] 401665 OR51T1 OR51T1 gene dto:DTO_02200407 An olfactory receptor 51V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C8] 283111 OR51V1 OR51A12 OR51V1 gene dto:DTO_02200408 An olfactory receptor 52A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKL2] 23538 OR52A1 OR52A1 gene dto:DTO_02200409 390053 OR52A4 OR52A4 gene dto:DTO_02200410 An olfactory receptor 52A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C5] 390054 OR52A5 OR52A5 gene dto:DTO_02200411 An olfactory receptor 52B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD2] 255725 OR52B2 OR52B2 gene dto:DTO_02200412 An olfactory receptor 52B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK2] 143496 OR52B4 OR52B4 gene dto:DTO_02200413 An olfactory receptor 52B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF0] 340980 OR52B6 OR52B6 gene dto:DTO_02200414 An olfactory receptor 52D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H346] 390066 OR52D1 OR52D1 gene dto:DTO_02200415 An olfactory receptor 52E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ3] 79296 OR52E1 OR52E1P OR52E1 gene dto:DTO_02200416 An olfactory receptor 52E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ4] 119678 OR52E2 OR52E2 gene dto:DTO_02200417 An olfactory receptor 52E4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH9] 390081 OR52E4 OR52E4 gene dto:DTO_02200418 An olfactory receptor 52E5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH55] 390082 OR52E5 OR52E5 gene dto:DTO_02200419 An olfactory receptor 52E6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD3] 390078 OR52E6 OR52E6 gene dto:DTO_02200420 An olfactory receptor 52E8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFG1] 390079 OR52E8 OR52E8 gene dto:DTO_02200421 An olfactory receptor 52H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ2] 390067 OR52H1 OR52H1 gene dto:DTO_02200422 An olfactory receptor 52I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK6] 390037 OR52I1 OR52I1 gene dto:DTO_02200423 An olfactory receptor 52I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH67] 143502 OR52I2 OR52I2 gene dto:DTO_02200424 An olfactory receptor 52J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH60] 119679 OR52J3 OR52J3 gene dto:DTO_02200425 An olfactory receptor 52K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK4] 390036 OR52K1 OR52K1 gene dto:DTO_02200426 An olfactory receptor 52K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK3] 119774 OR52K2 OR52K2 gene dto:DTO_02200427 An olfactory receptor 52L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH7] 338751 OR52L1 OR52L1 gene dto:DTO_02200428 79274 OR52L2P OR52L2 OR52L2P gene dto:DTO_02200429 An olfactory receptor 52M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK5] 119772 OR52M1 OR52M1P OR52M1 gene dto:DTO_02200430 An olfactory receptor 52N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH53] 79473 OR52N1 OR52N1 gene dto:DTO_02200431 An olfactory receptor 52N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI0] 390077 OR52N2 OR52N2 gene dto:DTO_02200432 An olfactory receptor 52N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI2] 390072 OR52N4 OR52N4 gene dto:DTO_02200433 An olfactory receptor 52N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH56] 390075 OR52N5 OR52N5 gene dto:DTO_02200434 81248 OR52P1P OR52P1 OR52P1P gene dto:DTO_02200435 An olfactory receptor 52R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF1] 119695 OR52R1 OR52R1 gene dto:DTO_02200436 An olfactory receptor 52W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF63] 120787 OR52W1 OR52W1P OR52W1 gene dto:DTO_02200437 An olfactory receptor 52Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C646] 283110 OR52Z1 OR52Z1P OR52Z1 gene dto:DTO_02200438 An olfactory receptor 56A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH5] 120796 OR56A1 OR56A1 gene dto:DTO_02200439 An olfactory receptor 56A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH54] 390083 OR56A3 OR56A3P OR56A6 OR56A3 gene dto:DTO_02200440 An olfactory receptor 56A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH8] 120793 OR56A4 OR56A4 gene dto:DTO_02200441 An olfactory receptor 56A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T3] 390084 OR56A5 OR56A5P OR56A5 gene dto:DTO_02200442 An olfactory receptor 56B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI3] 387748 OR56B1 OR56B1P OR56B1 gene dto:DTO_02200443 390073 OR56B2P OR56B2P gene dto:DTO_02200444 An olfactory receptor 56B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH76] 196335 OR56B4 OR56B4 gene dto:DTO_02200445 An olfactory receptor 5AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C628] 81431 OR5AC1 OR5AC1P OR5AC1 gene dto:DTO_02200446 An olfactory receptor 5AC2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP5] 81050 OR5AC2 OR5AC2 gene dto:DTO_02200447 An olfactory receptor 5AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH90] 390181 OR5AK2 OR5AK2 gene dto:DTO_02200448 81228 OR5AK3P OR5AK3 OR5AK3P gene dto:DTO_02200449 An olfactory receptor 5AL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C617] 79482 OR5AL1 OR5AL1P OR5AL1 gene dto:DTO_02200450 An olfactory receptor 5AN1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI8] 390195 OR5AN1 OR5AN1 gene dto:DTO_02200451 An olfactory receptor 5AP2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF4] 338675 OR5AP2 OR5AP2 gene dto:DTO_02200452 An olfactory receptor 5AR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP9] 219493 OR5AR1 OR5AR1 gene dto:DTO_02200453 An olfactory receptor 5AS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N127] 219447 OR5AS1 OR5AS1 gene dto:DTO_02200454 An olfactory receptor 5AU1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC0] 390445 OR5AU1 OR5AU1 gene dto:DTO_02200455 An olfactory receptor 5H14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHG9] 403273 OR5H14 OR5H14 gene dto:DTO_02200456 An olfactory receptor 5H15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDH6] 403274 OR5H15 OR5H15 gene dto:DTO_02200457 An olfactory receptor 6C65 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NJZ3] 403282 OR6C65 OR6C65 gene dto:DTO_02200458 An olfactory receptor 6C68 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDL8] 403284 OR6C68 OR6C68 gene dto:DTO_02200459 An olfactory receptor 6C70 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NIJ9] 390327 OR6C70 OR6C70 gene dto:DTO_02200460 An olfactory receptor 6C74 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NCV1] 254783 OR6C74 OR6C74 gene dto:DTO_02200461 An olfactory receptor 6C75 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL08] 390323 OR6C75 OR6C75 gene dto:DTO_02200462 An olfactory receptor 6C76 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM76] 390326 OR6C76 OR6C76 gene dto:DTO_02200463 An olfactory receptor 7E24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFN5] 26648 OR7E24 OR7E24P OR7E24 gene dto:DTO_02200464 A sphingosylphosphorylcholine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15743] 8111 GPR68 OGR1 GPR68 gene dto:DTO_02200465 An encephalopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1Y3] 23596 OPN3 ECPN OPN3 gene dto:DTO_02200466 A melanopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UHM6] 94233 OPN4 MOP OPN4 gene dto:DTO_02200467 An opsin-5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6U736] 221391 OPN5 GPR136 PGR12 TMEM13 OPN5 gene dto:DTO_02200468 A delta-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41143] 4985 OPRD1 OPRD OPRD1 gene dto:DTO_02200469 A kappa-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41145] 4986 OPRK1 OPRK OPRK1 gene dto:DTO_02200470 A mu-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35372] 4988 OPRM1 MOR1 OPRM1 gene dto:DTO_02200471 A nociceptin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41146] 4987 OPRL1 OOR ORL1 OPRL1 gene dto:DTO_02200472 A short-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P03999] 611 OPN1SW BCP OPN1SW gene dto:DTO_02200473 A rhodopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08100] 6010 RHO OPN2 RHO gene dto:DTO_02200474 A medium-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB] 101060233 2652 728458 OPN1MW GCP OPN1MW2 OPN1MW; OPN1MW2 gene dto:DTO_02200475 A long-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04000] 5956 OPN1LW RCP OPN1LW gene dto:DTO_02200476 A visual pigment-like receptor peropsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14718] 10692 RRH RRH gene dto:DTO_02200477 An olfactory receptor 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P1Q5] 8383 OR1A1 OR1A1 gene dto:DTO_02200478 An olfactory receptor 1A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y585] 26189 OR1A2 OR1A2 gene dto:DTO_02200479 An olfactory receptor 1B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR6] 347169 OR1B1 OR1B1 gene dto:DTO_02200480 An olfactory receptor 1C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15619] 26188 OR1C1 OR1C1 gene dto:DTO_02200481 An olfactory receptor 1D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34982] 4991 OR1D2 OLFR1 OR1D2 gene dto:DTO_02200482 An olfactory receptor 1D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47884] 653166 OR1D4 OR1D4 gene dto:DTO_02200483 An olfactory receptor 1D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58170] 8386 OR1D5 OR1D5 gene dto:DTO_02200484 An olfactory receptor 1E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30953] 8387 OR1E1 OR1E5 OR1E6 OR1E9P OR1E1 gene dto:DTO_02200485 An olfactory receptor 1E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47887] 8388 OR1E2 OR1E4 OR1E2 gene dto:DTO_02200486 An olfactory receptor 1E3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZA6] 8389 OR1E3 OR1E3P OR1E3 gene dto:DTO_02200487 An olfactory receptor 1F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43749] 4992 OR1F1 OLFMF OR1F10 OR1F4 OR1F5 OR1F6 OR1F7 OR1F8 OR1F9 OR1F1 gene dto:DTO_02200488 An olfactory receptor 1F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R84] 26184 OR1F2P OR1F2 OR1F2P gene dto:DTO_02200489 An olfactory receptor 1F12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA8] 442179 OR1F12 OR1F12P OR1F12 gene dto:DTO_02200490 An olfactory receptor 1G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47890] 8390 OR1G1 OR1G2 OR1G1 gene dto:DTO_02200491 An olfactory receptor 1I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60431] 126370 OR1I1 OR1I1 gene dto:DTO_02200492 An olfactory receptor 1J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS3] 347168 OR1J1 OR1J1 gene dto:DTO_02200493 An olfactory receptor 1J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS2] 26740 OR1J2 OR1J3 OR1J5 OR1J2 gene dto:DTO_02200494 An olfactory receptor 1J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS1] 26219 OR1J4 OR1J4 gene dto:DTO_02200495 An olfactory receptor 1K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR3] 392392 OR1K1 OR1K1 gene dto:DTO_02200496 An olfactory receptor 1L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH94] 26737 OR1L1 OR1L2 OR1L1 gene dto:DTO_02200497 An olfactory receptor 1L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH93] 26735 OR1L3 OR1L3 gene dto:DTO_02200498 An olfactory receptor 1L4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR5] 254973 OR1L4 OR1L5 OR1L4 gene dto:DTO_02200499 An olfactory receptor 1L6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR2] 392390 OR1L6 OR1L7 OR1L6 gene dto:DTO_02200500 An olfactory receptor 1L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR8] 138881 OR1L8 OR1L8 gene dto:DTO_02200501 An olfactory receptor 1M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA1] 125963 OR1M1 OR1M1 gene dto:DTO_02200502 An olfactory receptor 1N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS0] 138883 OR1N1 OR1N3 OR1N1 gene dto:DTO_02200503 An olfactory receptor 1N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR9] 138882 OR1N2 OR1N2 gene dto:DTO_02200504 An olfactory receptor 1P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH06] 8391 OR1P1 OR1P1P OR1P1 gene dto:DTO_02200505 An olfactory receptor 1Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15612] 158131 OR1Q1 OR1Q2 OR1Q3 OR1Q1 gene dto:DTO_02200506 An olfactory receptor 1S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH92] 219959 OR1S1 OR1S1 gene dto:DTO_02200507 An olfactory receptor 1S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ3] 219958 OR1S2 OR1S2 gene dto:DTO_02200508 An olfactory receptor 2A1/2A42 that is encoded in the genome of human. 346528 402317 OR2A1 OR2A42 OR2A1; OR2A42 gene dto:DTO_02200509 An olfactory receptor 2A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF42] 442361 OR2A2 OR2A17P OR2A2P OR2A2 gene dto:DTO_02200510 An olfactory receptor 2A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95047] 79541 OR2A4 OR2A10 OR2A4 gene dto:DTO_02200511 An olfactory receptor 2A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R48] 393046 OR2A5 OR2A26 OR2A8 OR2A5 gene dto:DTO_02200512 An olfactory receptor 2A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R45] 102725084 401427 OR2A7 OR2A7 gene dto:DTO_02200513 An olfactory receptor 2B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK3] 81697 OR2B2 OR2B9 OR2B2 gene dto:DTO_02200514 An olfactory receptor 2B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76000] 442184 OR2B3 OR2B3P OR2B3 gene dto:DTO_02200515 An olfactory receptor 2B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58173] 26212 OR2B6 OR2B1 OR2B1P OR2B5 OR2B6P OR2B6 gene dto:DTO_02200516 65944 OR2B8P OR2B8 OR2B8P gene dto:DTO_02200517 An olfactory receptor 2B11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JQS5] 127623 OR2B11 OR2B11 gene dto:DTO_02200518 An olfactory receptor 2C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95371] 4993 OR2C1 OR2C2P OR2C1 gene dto:DTO_02200519 An olfactory receptor 2C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N628] 81472 OR2C3 OR2C4 OR2C5P OR2C3 gene dto:DTO_02200520 An olfactory receptor 2D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H210] 120776 OR2D2 OR2D1 OR2D2 gene dto:DTO_02200521 An olfactory receptor 2D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH3] 120775 OR2D3 OR2D3 gene dto:DTO_02200522 An olfactory receptor 2F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13607] 26211 OR2F1 OLF3 OR2F3 OR2F3P OR2F4 OR2F5 OR2F1 gene dto:DTO_02200523 An olfactory receptor 2F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95006] 135948 OR2F2 OR2F2 gene dto:DTO_02200524 An olfactory receptor 2G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ5] 81470 OR2G2 OR2G2 gene dto:DTO_02200525 An olfactory receptor 2G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ4] 81469 OR2G3 OR2G3 gene dto:DTO_02200526 An olfactory receptor 2G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TZ20] 391211 OR2G6 OR2G6 gene dto:DTO_02200527 An olfactory receptor 2H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK4] 26716 OR2H1 OR2H6 OR2H8 OR2H1 gene dto:DTO_02200528 An olfactory receptor 2H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95918] 7932 OR2H2 FAT11 OLFR2 OR2H3 OR2H2 gene dto:DTO_02200529 442197 OR2I1P OR2I2 OR2I3P OR2I4P OR2I1P gene dto:DTO_02200530 An olfactory receptor 2J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK6] 442185 OR2J1 OR2J1P OR2J1 gene dto:DTO_02200531 An olfactory receptor 2J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76002] 26707 OR2J2 OR2J2 gene dto:DTO_02200532 An olfactory receptor 2J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76001] 442186 OR2J3 OR2J3 gene dto:DTO_02200533 An olfactory receptor 2K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT1] 26248 OR2K2 OR2AR1P OR2K2 gene dto:DTO_02200534 An olfactory receptor 2L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH16] 26246 OR2L2 OR2L12 OR2L4P OR2L2 gene dto:DTO_02200535 An olfactory receptor 2L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG85] 391192 OR2L3 OR2L3 gene dto:DTO_02200536 An olfactory receptor 2L5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG80] 81466 OR2L5 OR2L11 OR2L5 gene dto:DTO_02200537 An olfactory receptor 2L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY9] 391190 OR2L8 OR2L8 gene dto:DTO_02200538 An olfactory receptor 2L13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N349] 284521 OR2L13 OR2L14 OR2L13 gene dto:DTO_02200539 An olfactory receptor 2M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R28] 391194 OR2M2 OR2M2 gene dto:DTO_02200540 An olfactory receptor 2M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG83] 127062 OR2M3 OR2M3P OR2M6 OR2M3 gene dto:DTO_02200541 An olfactory receptor 2M4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R27] 26245 OR2M4 OR2M4 gene dto:DTO_02200542 An olfactory receptor 2M5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A3KFT3] 127059 OR2M5 OR2M5P OR2M5 gene dto:DTO_02200543 An olfactory receptor 2M7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG81] 391196 OR2M7 OR2M7 gene dto:DTO_02200544 An olfactory receptor 2S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQN1] 56656 OR2S2 OR2S2 gene dto:DTO_02200545 An olfactory receptor 2T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43869] 26696 OR2T1 OR2T1 gene dto:DTO_02200546 An olfactory receptor 2T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF00] 401992 OR2T2 OR2T2P OR2T2 gene dto:DTO_02200547 An olfactory receptor 2T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH03] 343173 OR2T3 OR2T3 gene dto:DTO_02200548 An olfactory receptor 2T4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH00] 127074 OR2T4 OR2T4 gene dto:DTO_02200549 An olfactory receptor 2T5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEZ7] 401993 OR2T5 OR2T5 gene dto:DTO_02200550 An olfactory receptor 2T6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC8] 254879 OR2T6 OR2T6P OR2T9 OR2T6 gene dto:DTO_02200551 An olfactory receptor 2T7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T2] 81458 OR2T7 OR2T7P OR2T7 gene dto:DTO_02200552 An olfactory receptor 2T8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NH00] 343172 OR2T8 OR2T8P OR2T8 gene dto:DTO_02200553 An olfactory receptor 2V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB1] 26693 OR2V1 OR2V1 gene dto:DTO_02200554 An olfactory receptor 2V2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R30] 285659 OR2V2 OR2V3 OR2V2 gene dto:DTO_02200555 An olfactory receptor 2W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3N9] 26692 OR2W1 OR2W1 gene dto:DTO_02200556 An olfactory receptor 2W3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3T1] 343171 OR2W3 OR2W3P OR2W8P OR2W3 gene dto:DTO_02200557 441932 OR2W5 OR2W5P OR2W5 gene dto:DTO_02200558 81406 OR2W6P OR2W7P OR2W6P gene dto:DTO_02200559 An olfactory receptor 2Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV0] 134083 OR2Y1 OR2Y1 gene dto:DTO_02200560 An olfactory receptor 2Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG97] 284383 OR2Z1 OR2Z2 OR2Z1 gene dto:DTO_02200561 An olfactory receptor 3A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47881] 4994 OR3A1 OLFRA03 OR3A1 gene dto:DTO_02200562 An olfactory receptor 3A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47893] 4995 OR3A2 OLFRA04 OR3A2 gene dto:DTO_02200563 An olfactory receptor 3A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47888] 8392 OR3A3 OR3A6 OR3A7 OR3A8P OR3A3 gene dto:DTO_02200564 An olfactory receptor 3A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47883] 390756 OR3A4P OR3A4 OR3A5P OR3A4P gene dto:DTO_02200565 390134 OR4A4P OR4A4P gene dto:DTO_02200566 An olfactory receptor 4A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH83] 81318 OR4A5 OR4A5 gene dto:DTO_02200567 81315 OR4A8P OR4A8 OR4A8P gene dto:DTO_02200568 An olfactory receptor 4B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF8] 119765 OR4B1 OR4B1 gene dto:DTO_02200569 An olfactory receptor 4C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH37] 256144 OR4C3 OR4C3 gene dto:DTO_02200570 An olfactory receptor 4C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB2] 79346 OR4C5 OR4C5 gene dto:DTO_02200571 An olfactory receptor 4C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH72] 219432 OR4C6 OR4C6 gene dto:DTO_02200572 An olfactory receptor 4C11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEV9] 219429 OR4C11 OR4C11P OR4C11 gene dto:DTO_02200573 An olfactory receptor 4C12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R67] 283093 OR4C12 OR4C12 gene dto:DTO_02200574 An olfactory receptor 4C13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP0] 283092 OR4C13 OR4C13 gene dto:DTO_02200575 An olfactory receptor 4C15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM1] 81309 OR4C15 OR4C15 gene dto:DTO_02200576 An olfactory receptor 4C16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL9] 219428 OR4C16 OR4C16 gene dto:DTO_02200577 An olfactory receptor 4D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15615] 26689 OR4D1 OR4D3 OR4D1 gene dto:DTO_02200578 An olfactory receptor 4D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58180] 124538 OR4D2 OR4D2 gene dto:DTO_02200579 An olfactory receptor 4D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN0] 219875 OR4D5 OR4D5 gene dto:DTO_02200580 An olfactory receptor 4D6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ1] 219983 OR4D6 OR4D6 gene dto:DTO_02200581 An olfactory receptor 4D9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE8] 390199 OR4D9 OR4D9 gene dto:DTO_02200582 An olfactory receptor 4D10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI6] 390197 OR4D10 OR4D10P OR4D10 gene dto:DTO_02200583 An olfactory receptor 4D11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI4] 219986 OR4D11 OR4D11P OR4D11 gene dto:DTO_02200584 An olfactory receptor 4E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C645] 26687 OR4E1 OR4E1P OR4E1 gene dto:DTO_02200585 An olfactory receptor 4E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC2] 26686 OR4E2 OR4E2 gene dto:DTO_02200586 An olfactory receptor 4F3/4F16/4F29 that is encoded in the genome of human. 26683 729759 81399 OR4F3 OR4F16 OR4F29 OR4F3; OR4F16; OR4F29 gene dto:DTO_02200587 An olfactory receptor 4F4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R69] 26682 OR4F4 OR4F4 gene dto:DTO_02200588 An olfactory receptor 4F5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH21] 79501 OR4F5 OR4F5 gene dto:DTO_02200589 An olfactory receptor 4F6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB9] 390648 OR4F6 OR4F12 OR4F6 gene dto:DTO_02200590 An olfactory receptor 4K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD4] 79544 OR4K1 OR4K1 gene dto:DTO_02200591 An olfactory receptor 4K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD2] 390431 OR4K2 OR4K2 gene dto:DTO_02200592 An olfactory receptor 4K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R72] 283617 OR4K3 OR4K3P OR4K3 gene dto:DTO_02200593 An olfactory receptor 4K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD3] 79317 OR4K5 OR4K5 gene dto:DTO_02200594 An olfactory receptor 4K13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH42] 390433 OR4K13 OR4K13 gene dto:DTO_02200595 An olfactory receptor 4K14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD5] 122740 OR4K14 OR4K14 gene dto:DTO_02200596 An olfactory receptor 4K15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH41] 81127 OR4K15 OR4K15 gene dto:DTO_02200597 An olfactory receptor 4K17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC6] 390436 OR4K17 OR4K17 gene dto:DTO_02200598 An olfactory receptor 4L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH43] 122742 OR4L1 OR4L2P OR4L1 gene dto:DTO_02200599 An olfactory receptor 4M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD0] 441670 OR4M1 OR4M1 gene dto:DTO_02200600 An olfactory receptor 4M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB6] 390538 OR4M2 OR4M2 gene dto:DTO_02200601 An olfactory receptor 4N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD1] 390429 OR4N2 OR4N2 gene dto:DTO_02200602 An olfactory receptor 4N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y3] 102723532 283694 OR4N4 OR4N4 gene dto:DTO_02200603 An olfactory receptor 4N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IXE1] 390437 OR4N5 OR4N5 gene dto:DTO_02200604 An olfactory receptor 4P4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL7] 81300 OR4P4 OR4P3P OR4P4 gene dto:DTO_02200605 An olfactory receptor 4Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C623] 390432 OR4Q2 OR4Q2P OR4Q2 gene dto:DTO_02200606 An olfactory receptor 4Q3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH05] 441669 OR4Q3 C14orf13 OR4Q4 OR4Q3 gene dto:DTO_02200607 An olfactory receptor 4S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB4] 256148 OR4S1 OR4S1 gene dto:DTO_02200608 An olfactory receptor 4S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH73] 219431 OR4S2 OR4S2P OR4S2 gene dto:DTO_02200609 An olfactory receptor 4X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH49] 390113 OR4X1 OR4X1 gene dto:DTO_02200610 An olfactory receptor 4X2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF9] 119764 OR4X2 OR4X2 gene dto:DTO_02200611 An olfactory receptor 5A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ0] 219982 OR5A1 OR5A1P OR5A1 gene dto:DTO_02200612 An olfactory receptor 5A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI9] 219981 OR5A2 OR5A2 gene dto:DTO_02200613 An olfactory receptor 5B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R09] 390190 OR5B2 OR5B2 gene dto:DTO_02200614 An olfactory receptor 5B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH48] 441608 OR5B3 OR5B13 OR5B3 gene dto:DTO_02200615 An olfactory receptor 5B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R08] 390191 OR5B12 OR5B12P OR5B16 OR5B12 gene dto:DTO_02200616 An olfactory receptor 5B17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF7] 219965 OR5B17 OR5B20P OR5B17 gene dto:DTO_02200617 An olfactory receptor 5B21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL26] 219968 OR5B21 OR5B21 gene dto:DTO_02200618 An olfactory receptor 5C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR4] 392391 OR5C1 OR5C2P OR5C1 gene dto:DTO_02200619 An olfactory receptor 5D13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL4] 390142 OR5D13 OR5D13 gene dto:DTO_02200620 An olfactory receptor 5D14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL3] 219436 OR5D14 OR5D14 gene dto:DTO_02200621 An olfactory receptor 5D16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK9] 390144 OR5D16 OR5D16 gene dto:DTO_02200622 An olfactory receptor 5D18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL1] 219438 OR5D18 OR5D18 gene dto:DTO_02200623 An olfactory receptor 5F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95221] 338674 OR5F1 OR5F1 gene dto:DTO_02200624 An olfactory receptor 5G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C626] 81193 OR5G3 OR5G3P OR5G6P OR5G3 gene dto:DTO_02200625 An olfactory receptor 5H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NKK0] 26341 OR5H1 OR5H1 gene dto:DTO_02200626 An olfactory receptor 5H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV7] 79310 OR5H2 OR5H2 gene dto:DTO_02200627 An olfactory receptor 5H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV6] 79295 OR5H6 OR5H6 gene dto:DTO_02200628 An olfactory receptor 5I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13606] 10798 OR5I1 OLF1 OR5I1 gene dto:DTO_02200629 An olfactory receptor 5J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH18] 282775 OR5J2 OR5J2 gene dto:DTO_02200630 An olfactory receptor 5K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB7] 26339 OR5K1 OR5K1 gene dto:DTO_02200631 An olfactory receptor 5K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB8] 402135 OR5K2 OR5K2 gene dto:DTO_02200632 An olfactory receptor 5K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NET4] 403277 OR5K3 OR5K3 gene dto:DTO_02200633 An olfactory receptor 5K4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMS3] 403278 OR5K4 OR5K4 gene dto:DTO_02200634 An olfactory receptor 5L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL2] 219437 OR5L1 OR5L1 gene dto:DTO_02200635 An olfactory receptor 5L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL0] 26338 OR5L2 OR5L2 gene dto:DTO_02200636 An olfactory receptor 5M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP8] 390168 OR5M1 OR5M1 gene dto:DTO_02200637 An olfactory receptor 5M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP4] 219482 OR5M3 OR5M3 gene dto:DTO_02200638 An olfactory receptor 5M8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP6] 219484 OR5M8 OR5M8 gene dto:DTO_02200639 An olfactory receptor 5M9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP3] 390162 OR5M9 OR5M9 gene dto:DTO_02200640 An olfactory receptor 5M10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEU7] 390167 OR5M10 OR5M10 gene dto:DTO_02200641 An olfactory receptor 5M11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RB7] 219487 OR5M11 OR5M11 gene dto:DTO_02200642 An olfactory receptor 5P2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ92] 120065 OR5P2 OR5P2 gene dto:DTO_02200643 An olfactory receptor 5P3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ94] 120066 OR5P3 OR5P3 gene dto:DTO_02200644 An olfactory receptor 5R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH85] 219479 OR5R1 OR5R1P OR5R1 gene dto:DTO_02200645 An olfactory receptor 5T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG75] 390155 OR5T1 OR5T1P OR5T1 gene dto:DTO_02200646 An olfactory receptor 5T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG2] 219464 OR5T2 OR5T2 gene dto:DTO_02200647 An olfactory receptor 5T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG3] 390154 OR5T3 OR5T3 gene dto:DTO_02200648 An olfactory receptor 5V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF6] 81696 OR5V1 OR5V1 gene dto:DTO_02200649 An olfactory receptor 5W2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH69] 390148 OR5W2 OR5W2P OR5W3P OR5W2 gene dto:DTO_02200650 An olfactory receptor 6A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95222] 8590 OR6A2 OR6A1 OR6A2P OR6A2 gene dto:DTO_02200651 An olfactory receptor 6B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95007] 135946 OR6B1 OR6B1 gene dto:DTO_02200652 An olfactory receptor 6B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFH4] 389090 OR6B2 OR6B2P OR6B2 gene dto:DTO_02200653 An olfactory receptor 6B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW1] 150681 OR6B3 OR6B3P OR6B3 gene dto:DTO_02200654 An olfactory receptor 6C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD1] 390321 OR6C1 OR6C1 gene dto:DTO_02200655 An olfactory receptor 6C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP2] 341416 OR6C2 OR6C2 gene dto:DTO_02200656 An olfactory receptor 6C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP0] 254786 OR6C3 OR6C3 gene dto:DTO_02200657 An olfactory receptor 6C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE1] 341418 OR6C4 OR6C4 gene dto:DTO_02200658 An olfactory receptor 6C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NF89] 283365 OR6C6 OR6C6 gene dto:DTO_02200659 An olfactory receptor 6F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ6] 343169 OR6F1 OR6F1 gene dto:DTO_02200660 An olfactory receptor 6J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC5] 79549 OR6J1 OR6J2 OR6J1 gene dto:DTO_02200661 An olfactory receptor 6K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY2] 81448 OR6K2 OR6K2 gene dto:DTO_02200662 An olfactory receptor 6K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY3] 391114 OR6K3 OR6K3 gene dto:DTO_02200663 An olfactory receptor 6K6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW6] 128371 OR6K6 OR6K6 gene dto:DTO_02200664 An olfactory receptor 6M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM8] 390261 OR6M1 OR6M1 gene dto:DTO_02200665 An olfactory receptor 6N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY5] 128372 OR6N1 OR6N1 gene dto:DTO_02200666 An olfactory receptor 6N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY6] 81442 OR6N2 OR6N2 gene dto:DTO_02200667 An olfactory receptor 6P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX9] 128366 OR6P1 OR6P1 gene dto:DTO_02200668 An olfactory receptor 6Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ2] 219952 OR6Q1 OR6Q1 gene dto:DTO_02200669 An olfactory receptor 6S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH40] 341799 OR6S1 OR6S1 gene dto:DTO_02200670 An olfactory receptor 6T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN1] 219874 OR6T1 OR6T1 gene dto:DTO_02200671 An olfactory receptor 6V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N148] 346517 OR6V1 OR6V1 gene dto:DTO_02200672 An olfactory receptor 6X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH79] 390260 OR6X1 OR6X1 gene dto:DTO_02200673 An olfactory receptor 6Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX8] 391112 OR6Y1 OR6Y2 OR6Y1 gene dto:DTO_02200674 390894 OR7A2P OR7A2 OR7A7 OR7A2P gene dto:DTO_02200675 An olfactory receptor 7A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15622] 26659 OR7A5 OR7A5 gene dto:DTO_02200676 An olfactory receptor 7A10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76100] 390892 OR7A10 OR7A10 gene dto:DTO_02200677 An olfactory receptor 7A17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14581] 26333 OR7A17 OR7A17 gene dto:DTO_02200678 An olfactory receptor 7C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76099] 26664 OR7C1 OR7C4 OR7C1 gene dto:DTO_02200679 An olfactory receptor 7C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60412] 26658 OR7C2 OR7C3 OR7C2 gene dto:DTO_02200680 An olfactory receptor 7D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RA2] 162998 OR7D2 OR7D2 gene dto:DTO_02200681 An olfactory receptor 7D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG98] 125958 OR7D4 OR7D4P OR7D4 gene dto:DTO_02200682 An olfactory receptor 7G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA0] 125962 OR7G1 OR7G1P OR7G1 gene dto:DTO_02200683 An olfactory receptor 7G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG99] 390882 OR7G2 OR7G2 gene dto:DTO_02200684 An olfactory receptor 7G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG95] 390883 OR7G3 OR7G3 gene dto:DTO_02200685 An olfactory receptor 8A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG7] 390275 OR8A1 OR8A1 gene dto:DTO_02200686 An olfactory receptor 8B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD0] 26595 OR8B2 OR8B2 gene dto:DTO_02200687 An olfactory receptor 8B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG8] 390271 OR8B3 OR8B3 gene dto:DTO_02200688 An olfactory receptor 8B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RC9] 283162 OR8B4 OR8B4P OR8B4 gene dto:DTO_02200689 An olfactory receptor 8B8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15620] 26493 OR8B8 OR8B8 gene dto:DTO_02200690 An olfactory receptor 8B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG6] 219858 OR8B12 OR8B12 gene dto:DTO_02200691 An olfactory receptor 8D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ84] 283159 OR8D1 OR8D3 OR8D1 gene dto:DTO_02200692 An olfactory receptor 8D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZM6] 283160 OR8D2 OR8D2 gene dto:DTO_02200693 An olfactory receptor 8D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM9] 338662 OR8D4 OR8D4 gene dto:DTO_02200694 An olfactory receptor 8G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15617] 26494 OR8G1 OR8G1P OR8G1 gene dto:DTO_02200695 An olfactory receptor 8G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15614] 26492 OR8G2 OR8G2P OR8G4 OR8G2 gene dto:DTO_02200696 An olfactory receptor 8G5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG78] 219865 OR8G5 OR8G5P OR8G6 OR8G5 gene dto:DTO_02200697 An olfactory receptor 8H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG4] 219469 OR8H1 OR8H1 gene dto:DTO_02200698 An olfactory receptor 8H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N162] 390151 OR8H2 OR8H2 gene dto:DTO_02200699 An olfactory receptor 8H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N146] 390152 OR8H3 OR8H3 gene dto:DTO_02200700 An olfactory receptor 8I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y5] 120586 OR8I2 OR8I2 gene dto:DTO_02200701 An olfactory receptor 8J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP2] 219477 OR8J1 OR8J1 gene dto:DTO_02200702 An olfactory receptor 8J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG1] 81169 OR8J2 OR8J2P OR8J2 gene dto:DTO_02200703 An olfactory receptor 8J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG0] 81168 OR8J3 OR8J3 gene dto:DTO_02200704 An olfactory receptor 8K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG5] 390157 OR8K1 OR8K1 gene dto:DTO_02200705 An olfactory receptor 8K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH51] 219473 OR8K3 OR8K3 gene dto:DTO_02200706 An olfactory receptor 8K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH50] 219453 OR8K5 OR8K5 gene dto:DTO_02200707 An olfactory receptor 8S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH09] 341568 OR8S1 OR8S1 gene dto:DTO_02200708 An olfactory receptor 8U1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH10] 219417 OR8U1 OR8U1 gene dto:DTO_02200709 An olfactory receptor 8U8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N1] 504189 OR8U8 OR8U8 gene dto:DTO_02200710 An olfactory receptor 8U9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N5] 504190 OR8U9 OR8U9 gene dto:DTO_02200711 26495 OR9A1P OR9A1 OR9A1P gene dto:DTO_02200712 An olfactory receptor 9A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT5] 135924 OR9A2 OR9A2 gene dto:DTO_02200713 An olfactory receptor 9A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGU2] 130075 OR9A4 OR9A4 gene dto:DTO_02200714 An olfactory receptor 9G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH87] 390174 OR9G1 OR9G5 OR9G1 gene dto:DTO_02200715 An olfactory receptor 9G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ1] 283189 OR9G4 OR9G4 gene dto:DTO_02200716 An olfactory receptor 9G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N8] 504191 OR9G9 OR9G9 gene dto:DTO_02200717 An olfactory receptor 9I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ6] 219954 OR9I1 OR9I1 gene dto:DTO_02200718 An olfactory receptor 9K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE7] 441639 OR9K2 OR9K2 gene dto:DTO_02200719 An olfactory receptor 9Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ5] 219956 OR9Q1 OR9Q1 gene dto:DTO_02200720 An olfactory receptor 9Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE9] 219957 OR9Q2 OR9Q2P OR9Q2 gene dto:DTO_02200721 An orexin receptor type 1 that is encoded in the genome of human. [Reactome:REACT_17344] 3061 HCRTR1 HCRTR1 gene dto:DTO_02200722 An orexin receptor type 2 that is encoded in the genome of human. [Reactome:REACT_17071] 3062 HCRTR2 HCRTR2 gene dto:DTO_02200723 An oxoeicosanoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS5] 165140 OXER1 GPR170 TG1019 OXER1 gene dto:DTO_02200724 A 2-oxoglutarate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P68] 27199 OXGR1 GPR80 GPR99 P2RY15 P2Y15 OXGR1 gene dto:DTO_02200725 An oxytocin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30559] 5021 OXTR OXTR gene dto:DTO_02200726 A P2Y purinoceptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47900] 5028 P2RY1 P2RY1 gene dto:DTO_02200727 A P2Y purinoceptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41231] 5029 P2RY2 P2RU1 P2RY2 gene dto:DTO_02200728 A P2Y purinoceptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51582] 5030 P2RY4 NRU P2RY4 gene dto:DTO_02200729 A P2Y purinoceptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15077] 5031 P2RY6 P2RY6 gene dto:DTO_02200730 A P2Y purinoceptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86VZ1] 286530 P2RY8 P2RY8 gene dto:DTO_02200731 A P2Y purinoceptor 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00398] 27334 P2RY10 P2RY10 gene dto:DTO_02200732 A P2Y purinoceptor 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96G91] 5032 P2RY11 P2RY11 gene dto:DTO_02200733 A P2Y purinoceptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H244] 64805 P2RY12 HORK3 P2RY12 gene dto:DTO_02200734 A P2Y purinoceptor 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BPV8] 53829 P2RY13 GPR86 GPR94 P2RY13 gene dto:DTO_02200735 A P2Y purinoceptor 14 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15391] 9934 P2RY14 GPR105 KIAA0001 P2RY14 gene dto:DTO_02200736 A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41586] 117 ADCYAP1R1 ADCYAP1R1 gene dto:DTO_02200737 A proteinase-activated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25116] 2149 F2R CF2R PAR1 TR F2R gene dto:DTO_02200738 A proteinase-activated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P55085] 2150 F2RL1 GPR11 PAR2 F2RL1 gene dto:DTO_02200739 A proteinase-activated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00254] 2151 F2RL2 PAR3 F2RL2 gene dto:DTO_02200740 A proteinase-activated receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI0] 9002 F2RL3 PAR4 F2RL3 gene dto:DTO_02200741 A prostaglandin D2 receptor DP2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y4] 11251 PTGDR2 CRTH2 DL1R GPR44 PTGDR2 gene dto:DTO_02200742 A prostaglandin D2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13258] 5729 PTGDR PTGDR gene dto:DTO_02200743 A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34995] 5731 PTGER1 PTGER1 gene dto:DTO_02200744 A prostaglandin E2 receptor EP2 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43116] 5732 PTGER2 PTGER2 gene dto:DTO_02200745 A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43115] 5733 PTGER3 PTGER3 gene dto:DTO_02200746 A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35408] 5734 PTGER4 PTGER2 PTGER4 gene dto:DTO_02200747 A prostaglandin F2-alpha receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43088] 5737 PTGFR PTGFR gene dto:DTO_02200748 A prostacyclin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43119] 5739 PTGIR PRIPR PTGIR gene dto:DTO_02200749 A prokineticin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TCW9] 10887 PROKR1 GPR73 PKR1 PROKR1 gene dto:DTO_02200750 A prokineticin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NFJ6] 128674 PROKR2 GPR73L1 PKR2 PROKR2 gene dto:DTO_02200751 A prolactin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49683] 2834 PRLHR GPR10 GR3 PRLHR gene dto:DTO_02200752 A psychosine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IYL9] 8477 GPR65 TDAG8 GPR65 gene dto:DTO_02200753 A platelet-activating factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25105] 5724 PTAFR PAFR PTAFR gene dto:DTO_02200754 A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03431] 5745 PTH1R PTHR PTHR1 PTH1R gene dto:DTO_02200755 A parathyroid hormone 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49190] 5746 PTH2R PTHR2 PTH2R gene dto:DTO_02200756 An orexigenic neuropeptide QRFP receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P65] 84109 QRFPR GPR103 QRFPR gene dto:DTO_02200757 A retinoic acid-induced protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFJ5] 9052 GPRC5A GPCR5A RAI3 RAIG1 GPRC5A gene dto:DTO_02200758 An RPE-retinal G protein-coupled receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47804] 5995 RGR RGR gene dto:DTO_02200759 A relaxin-3 receptor 1 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_21738] 51289 RXFP3 RLN3R1 SALPR RXFP3 gene dto:DTO_02200760 A relaxin-3 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU9] 339403 RXFP4 GPR100 RLN3R2 RXFP4 gene dto:DTO_02200761 A relaxin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX9] 59350 RXFP1 LGR7 RXFP1 gene dto:DTO_02200762 A relaxin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8WXD0] 122042 RXFP2 GPR106 GREAT LGR8 RXFP2 gene dto:DTO_02200763 A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21453] 1901 S1PR1 CHEDG1 EDG1 S1PR1 gene dto:DTO_02200764 A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95136] 9294 S1PR2 EDG5 S1PR2 gene dto:DTO_02200765 A sphingosine 1-phosphate receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99500] 1903 S1PR3 EDG3 S1PR3 gene dto:DTO_02200766 A sphingosine 1-phosphate receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95977] 8698 S1PR4 EDG6 S1PR4 gene dto:DTO_02200767 A sphingosine 1-phosphate receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H228] 53637 S1PR5 EDG8 S1PR5 gene dto:DTO_02200768 A secretin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47872] 6344 SCTR SCTR gene dto:DTO_02200769 A smoothened that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99835] 6608 SMO SMOH SMO gene dto:DTO_02200770 A somatostatin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30872] 6751 SSTR1 SSTR1 gene dto:DTO_02200771 A somatostatin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30874] 6752 SSTR2 SSTR2 gene dto:DTO_02200772 A somatostatin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32745] 6753 SSTR3 SSTR3 gene dto:DTO_02200773 A somatostatin receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31391] 6754 SSTR4 SSTR4 gene dto:DTO_02200774 A somatostatin receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35346] 6755 SSTR5 SSTR5 gene dto:DTO_02200775 A succinate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXA5] 56670 SUCNR1 GPR91 SUCNR1 gene dto:DTO_02200776 A taste receptor type 2 member 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW0] 50839 TAS2R10 TAS2R10 gene dto:DTO_02200777 A taste receptor type 2 member 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV9] 50838 TAS2R13 TAS2R13 gene dto:DTO_02200778 A taste receptor type 2 member 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV8] 50840 TAS2R14 TAS2R14 gene dto:DTO_02200779 A taste receptor type 2 member 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV7] 50833 TAS2R16 TAS2R16 gene dto:DTO_02200780 A taste receptor type 2 member 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59542] 259294 TAS2R19 TAS2R23 TAS2R48 TAS2R19 gene dto:DTO_02200781 A taste receptor type 2 member 20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59543] 259295 TAS2R20 TAS2R49 TAS2R20 gene dto:DTO_02200782 A taste receptor type 2 member 30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59541] 259293 TAS2R30 TAS2R47 TAS2R30 gene dto:DTO_02200783 A taste receptor type 2 member 44 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59538] 259290 TAS2R31 TAS2R44 TAS2R31 gene dto:DTO_02200784 A taste receptor type 2 member 38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59533] 5726 TAS2R38 PTC TAS2R38 gene dto:DTO_02200785 A taste receptor type 2 member 39 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59534] 259285 TAS2R39 TAS2R39 gene dto:DTO_02200786 A taste receptor type 2 member 40 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59535] 259286 TAS2R40 GPR60 TAS2R40 gene dto:DTO_02200787 A taste receptor type 2 member 41 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59536] 259287 TAS2R41 TAS2R41 gene dto:DTO_02200788 A taste receptor type 2 member 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTR8] 353164 TAS2R42 TAS2R55 TAS2R42 gene dto:DTO_02200789 A taste receptor type 2 member 43 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59537] 259289 TAS2R43 TAS2R43 gene dto:DTO_02200790 A taste receptor type 2 member 46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59540] 259292 TAS2R46 TAS2R46 gene dto:DTO_02200791 A taste receptor type 2 member 50 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59544] 259296 TAS2R50 TAS2R50 gene dto:DTO_02200792 A taste receptor type 2 member 60 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59551] 338398 TAS2R60 TAS2R60 gene dto:DTO_02200793 A taste receptor type 2 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW7] 50834 TAS2R1 TAS2R1 gene dto:DTO_02200794 A taste receptor type 2 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW6] 50831 TAS2R3 TAS2R3 gene dto:DTO_02200795 A taste receptor type 2 member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW5] 50832 TAS2R4 TAS2R4 gene dto:DTO_02200796 A taste receptor type 2 member 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW4] 54429 TAS2R5 TAS2R5 gene dto:DTO_02200797 A taste receptor type 2 member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW3] 50837 TAS2R7 TAS2R7 gene dto:DTO_02200798 A taste receptor type 2 member 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW2] 50836 TAS2R8 TAS2R8 gene dto:DTO_02200799 A taste receptor type 2 member 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW1] 50835 TAS2R9 TAS2R9 gene dto:DTO_02200800 A thromboxane A2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21731] 6915 TBXA2R TBXA2R gene dto:DTO_02200801 A trace amine-associated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RJ0] 134864 TAAR1 TA1 TAR1 TRAR1 TAAR1 gene dto:DTO_02200802 A trace amine-associated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P5] 9287 TAAR2 GPR58 TAAR2 gene dto:DTO_02200803 A trace amine-associated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P4] 9288 TAAR3 GPR57 TAAR3 gene dto:DTO_02200804 A trace amine-associated receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14804] 9038 TAAR5 PNR TAAR5 gene dto:DTO_02200805 A trace amine-associated receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI8] 319100 TAAR6 TA4 TAR4 TRAR4 TAAR6 gene dto:DTO_02200806 A trace amine-associated receptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969N4] 83551 TAAR8 GPR102 TA5 TAR5 TRAR5 TAAR8 gene dto:DTO_02200807 A trace amine-associated receptor 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI9] 134860 TAAR9 TA3 TAR3 TRAR3 TAAR9 gene dto:DTO_02200808 A transmembrane protein adipocyte-associated 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W33] 131601 TPRA1 GPR175 TMEM227 TPRA1 gene dto:DTO_02200809 A thyrotropin-releasing hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34981] 7201 TRHR TRHR gene dto:DTO_02200810 A taste receptor type 1 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX1] 80835 TAS1R1 GPR70 T1R1 TR1 TAS1R1 gene dto:DTO_02200811 A taste receptor type 1 member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE23] 80834 TAS1R2 GPR71 T1R2 TR2 TAS1R2 gene dto:DTO_02200812 A taste receptor type 1 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX0] 83756 TAS1R3 T1R3 TR3 TAS1R3 gene dto:DTO_02200813 A thyrotropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16473] 7253 TSHR LGR3 TSHR gene dto:DTO_02200814 A urotensin-2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UKP6] 2837 UTS2R GPR14 UTS2R gene dto:DTO_02200815 A vasopressin V1a receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P37288] 552 AVPR1A AVPR1 AVPR1A gene dto:DTO_02200816 A vasopressin V1b receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47901] 553 AVPR1B AVPR3 VPR3 AVPR1B gene dto:DTO_02200817 A vasopressin V2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30518] 554 AVPR2 ADHR DIR DIR3 V2R AVPR2 gene dto:DTO_02200818 A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32241] 7433 VIPR1 VIPR1 gene dto:DTO_02200819 A vasoactive intestinal polypeptide receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41587] 7434 VIPR2 VIP2R VIPR2 gene dto:DTO_02200820 A vomeronasal type-1 receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZP7] 57191 VN1R1 V1RL1 VNR19I1 VN1R1 gene dto:DTO_02200821 A vomeronasal type-1 receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFZ6] 317701 VN1R2 V1RL2 VN1R2 gene dto:DTO_02200822 A vomeronasal type-1 receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXE9] 317702 VN1R3 V1RL3 VN1R3 gene dto:DTO_02200823 A vomeronasal type-1 receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H5] 317703 VN1R4 V1RL4 VN1R4 gene dto:DTO_02200824 A vomeronasal type-1 receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H4] 317705 VN1R5 V1RL5 VN1R5 gene dto:DTO_02200826 A chemokine XC receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46094] 2829 XCR1 CCXCR1 GPR5 XCR1 gene dto:DTO_02200827 392311 OR13C6P OR13C6P gene dto:DTO_02300001 G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes. https://www.nature.com/scitable/topicpage/gpcr-14047471 GPCR dto:DTO_02300002 Class A rhodopsin like dto:DTO_02300003 Class B secretin like dto:DTO_02300004 Class C metabotropic glutamate/pheromone dto:DTO_02300005 Class F frizzled-type dto:DTO_02300006 Other 7TM proteins dto:DTO_02300013 Olfactory receptor dto:DTO_02300014 Taste 2 receptor dto:DTO_02300015 Taste 1 receptor dto:DTO_02300016 Vomeronasal receptor dto:DTO_02300017 5-hydroxytryptamine receptor dto:DTO_02300018 Adenosine receptor dto:DTO_02300020 Acetylcholine receptor (muscarinic) dto:DTO_02300021 Melanocortin receptor dto:DTO_02300022 Adrenoceptor dto:DTO_02300023 Angiotensin receptor dto:DTO_02300024 Apelin receptor dto:DTO_02300025 Bradykinin receptor dto:DTO_02300026 Bombesin receptor dto:DTO_02300027 Anaphylatoxin receptor dto:DTO_02300028 Calcitonin receptor dto:DTO_02300029 Calcium-sensing receptor dto:DTO_02300030 Cholecystokinin receptor dto:DTO_02300031 Chemokine receptor dto:DTO_02300032 Cadherin EGF LAG (CELSR) receptor dto:DTO_02300033 Leukotriene receptor dto:DTO_02300034 Chemerin receptor dto:DTO_02300035 Cannabinoid receptor dto:DTO_02300036 Corticotropin-releasing factor receptor dto:DTO_02300037 Dopamine receptor dto:DTO_02300038 Endothelin receptor dto:DTO_02300039 Latrophilin receptor dto:DTO_02300040 Free fatty acid receptor dto:DTO_02300041 Formyl peptide receptor dto:DTO_02300042 Glycoprotein hormone receptor dto:DTO_02300043 Frizzled receptor dto:DTO_02300044 GPR137 family dto:DTO_02300045 GABA-B receptor dto:DTO_02300046 Galanin receptor dto:DTO_02300047 Glucagon receptor dto:DTO_02300048 Ghrelin receptor dto:DTO_02300050 Gonadotrophin-releasing hormone receptor dto:DTO_02300051 LU7TM family dto:DTO_02300052 Melanin-concentrating hormone receptor dto:DTO_02300053 Purinoceptor dto:DTO_02300054 Adrenomedullin receptor dto:DTO_02300055 Bile acid receptor dto:DTO_02300056 Estrogen (G protein-coupled) receptor dto:DTO_02300057 Chemokine receptor-like dto:DTO_02300058 Galanin like dto:DTO_02300059 Metabotropic glutamate receptor dto:DTO_02300060 Hydroxycarboxylic acid receptor dto:DTO_02300061 Histamine receptor dto:DTO_02300062 Kisspeptin receptor dto:DTO_02300063 Mas proto-oncogene and Mas-related (MRGs) receptor dto:DTO_02300064 Motilin receptor dto:DTO_02300065 Melatonin receptor dto:DTO_02300066 Tachykinin receptor dto:DTO_02300067 Neuromedin U receptor dto:DTO_02300068 Neuropeptide W/neuropeptide B receptor dto:DTO_02300069 Neuropeptide FF/neuropeptide AF receptor dto:DTO_02300070 Neuropeptide S receptor dto:DTO_02300071 Neuropeptide Y receptor dto:DTO_02300072 Neurotensin receptor dto:DTO_02300079 Proteinase-activated receptor dto:DTO_02300084 Parathyroid hormone receptor dto:DTO_02300090 UPF0359 family dto:DTO_02300093 Alpha adrenoceptor dto:DTO_02300094 Beta adrenoceptor dto:DTO_02300095 C-C chemokine receptor dto:DTO_02300096 C-X3-C chemokine receptor dto:DTO_02300097 C-X-C chemokine receptor dto:DTO_02300098 Endothelin type A dto:DTO_02300099 Endothelin type B dto:DTO_02300100 P2Y receptor dto:DTO_02302001 5-HT1 receptor dto:DTO_02302002 5-HT2 receptor dto:DTO_02302003 5-HT4 receptor dto:DTO_02302004 5-HT5 receptor dto:DTO_02302005 5-HT6 receptor dto:DTO_02302006 5-HT7 receptor dto:DTO_02302007 Lysophospholipid (LPA) receptor dto:DTO_02302008 Adhesion class dto:DTO_02390001 Aminergic GPCR dto:DTO_02390002 Lipidergic GPCR dto:DTO_02390003 Orphan GPCR dto:DTO_02390004 Peptidic GPCR dto:DTO_02400001 G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes. https://www.nature.com/scitable/topicpage/gpcr-14047471 GPCR gene dto:DTO_02400002 Class A rhodopsin like gene dto:DTO_02400003 Class B secretin like gene dto:DTO_02400004 Class C metabotropic glutamate/pheromone gene dto:DTO_02400005 Class F frizzled-type gene dto:DTO_02400006 Other 7TM proteins gene dto:DTO_02400013 Olfactory receptor gene dto:DTO_02400014 Taste 2 receptor gene dto:DTO_02400015 Taste 1 receptor gene dto:DTO_02400016 Vomeronasal receptor gene dto:DTO_02400017 5-hydroxytryptamine receptor gene dto:DTO_02400018 Adenosine receptor gene dto:DTO_02400020 Acetylcholine receptor (muscarinic) gene dto:DTO_02400021 Melanocortin receptor gene dto:DTO_02400022 Adrenoceptor gene dto:DTO_02400023 Angiotensin receptor gene dto:DTO_02400024 Apelin receptor gene dto:DTO_02400025 Bradykinin receptor gene dto:DTO_02400026 Bombesin receptor gene dto:DTO_02400027 Anaphylatoxin receptor gene dto:DTO_02400028 Calcitonin receptor gene dto:DTO_02400029 Calcium-sensing receptor gene dto:DTO_02400030 Cholecystokinin receptor gene dto:DTO_02400031 Chemokine receptor gene dto:DTO_02400032 Cadherin EGF LAG (CELSR) receptor gene dto:DTO_02400033 Leukotriene receptor gene dto:DTO_02400034 Chemerin receptor gene dto:DTO_02400035 Cannabinoid receptor gene dto:DTO_02400036 Corticotropin-releasing factor receptor gene dto:DTO_02400037 Dopamine receptor gene dto:DTO_02400038 Endothelin receptor gene dto:DTO_02400039 Latrophilin receptor gene dto:DTO_02400040 Free fatty acid receptor gene dto:DTO_02400041 Formyl peptide receptor gene dto:DTO_02400042 Glycoprotein hormone receptor gene dto:DTO_02400043 Frizzled receptor gene dto:DTO_02400044 GPR137 family gene dto:DTO_02400045 GABA-B receptor gene dto:DTO_02400046 Galanin receptor gene dto:DTO_02400047 Glucagon receptor gene dto:DTO_02400048 Ghrelin receptor gene dto:DTO_02400050 Gonadotrophin-releasing hormone receptor gene dto:DTO_02400051 LU7TM family gene dto:DTO_02400052 Melanin-concentrating hormone receptor gene dto:DTO_02400053 Purinoceptor gene dto:DTO_02400054 Adrenomedullin receptor gene dto:DTO_02400055 Bile acid receptor gene dto:DTO_02400056 Estrogen (G protein-coupled) receptor gene dto:DTO_02400057 Chemokine receptor-like gene dto:DTO_02400058 Galanin like gene dto:DTO_02400059 Metabotropic glutamate receptor gene dto:DTO_02400060 Hydroxycarboxylic acid receptor gene dto:DTO_02400061 Histamine receptor gene dto:DTO_02400062 Kisspeptin receptor gene dto:DTO_02400063 Mas proto-oncogene and Mas-related (MRGs) receptor gene dto:DTO_02400064 Motilin receptor gene dto:DTO_02400065 Melatonin receptor gene dto:DTO_02400066 Tachykinin receptor gene dto:DTO_02400067 Neuromedin U receptor gene dto:DTO_02400068 Neuropeptide W/neuropeptide B receptor gene dto:DTO_02400069 Neuropeptide FF/neuropeptide AF receptor gene dto:DTO_02400070 Neuropeptide S receptor gene dto:DTO_02400071 Neuropeptide Y receptor gene dto:DTO_02400072 Neurotensin receptor gene dto:DTO_02400079 Proteinase-activated receptor gene dto:DTO_02400084 Parathyroid hormone receptor gene dto:DTO_02400090 UPF0359 family gene dto:DTO_02400093 Alpha adrenoceptor gene dto:DTO_02400094 Beta adrenoceptor gene dto:DTO_02400095 C-C chemokine receptor gene dto:DTO_02400096 C-X3-C chemokine receptor gene dto:DTO_02400097 C-X-C chemokine receptor gene dto:DTO_02400098 Endothelin type A gene dto:DTO_02400099 Endothelin type B gene dto:DTO_02400100 P2Y receptor gene dto:DTO_02402001 5-HT1 receptor gene dto:DTO_02402002 5-HT2 receptor gene dto:DTO_02402003 5-HT4 receptor gene dto:DTO_02402004 5-HT5 receptor gene dto:DTO_02402005 5-HT6 receptor gene dto:DTO_02402006 5-HT7 receptor gene dto:DTO_02402007 Lysophospholipid (LPA) receptor gene dto:DTO_02402008 Adhesion class gene dto:DTO_02402009 NPY6R NPY6R gene dto:DTO_02402010 VN1R17P VN1R17P gene dto:DTO_03100001 AP2-associated protein kinase 1 (AAK1) with no mutation in a nonphosphorylated state An AP2-associated protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q2M2I8] https://pharos.nih.gov/idg/targets/Q2M2I8 AAK1 KIAA1048 Q2M2I8 Ap2-associated protein kinase 1 dto:DTO_03100002 A 5'-AMP-activated protein kinase subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y478] https://pharos.nih.gov/idg/targets/Q9Y478 PRKAB1 AMPK Q9Y478 5'-AMP-activated protein kinase subunit beta-1 dto:DTO_03100003 A 5'-AMP-activated protein kinase subunit gamma-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54619] https://pharos.nih.gov/idg/targets/P54619 PRKAG1 P54619 5'-AMP-activated protein kinase subunit gamma-1 dto:DTO_03100004 5-amp-activated protein kinase catalytic subunit alpha-1 (AMPK-alpha1) with no mutation in a nonphosphorylated state A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13131] https://pharos.nih.gov/idg/targets/Q13131 PRKAA1 AMPK1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 dto:DTO_03100005 5-amp-activated protein kinase catalytic subunit alpha-2 (AMPK-alpha2) with no mutation in a nonphosphorylated state A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54646] https://pharos.nih.gov/idg/targets/P54646 PRKAA2 AMPK AMPK2 P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 dto:DTO_03100006 A tyrosine-protein kinase ABL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00519] tyrosine-protein kinase abl1 (ABL1(E255K)) with mutation K255 in ABL1(E255K) in a nonphosphorylated state tyrosine-protein kinase abl1 (ABL1(E255K)-phosphorylated) with mutation K255 in ABL1(E255K)-phosphorylated in a phosphorylated state tyrosine-protein kinase abl1 (ABL1(F317I)-nonphosphorylated) with mutation I317 in ABL1(F317I)-nonphosphorylated in a nonphosphorylated state tyrosine-protein kinase abl1 (ABL1(F317I)-phosphorylated) with mutation I317 in ABL1(F317I)-phosphorylated in a phosphorylated state tyrosine-protein kinase abl1 (ABL1(F317L)-nonphosphorylated) with mutation L317 in ABL1(F317L)-nonphosphorylated in a nonphosphorylated state tyrosine-protein kinase abl1 (ABL1(F317L)-phosphorylated) with mutation L317 in ABL1(F317L)-phosphorylated in a phosphorylated state tyrosine-protein kinase abl1 (ABL1(H396P)-nonphosphorylated) with mutation P396 in ABL1(H396P)-nonphosphorylated in a nonphosphorylated state tyrosine-protein kinase abl1 (ABL1(H396P)-phosphorylated) with mutation P396 in ABL1(H396P)-phosphorylated in a phosphorylated state tyrosine-protein kinase abl1 (ABL1(M351T)) with mutation T351 in ABL1(M351T) in a nonphosphorylated state tyrosine-protein kinase abl1 (ABL1(M351T)-phosphorylated) with mutation T351 in ABL1(M351T)-phosphorylated in a phosphorylated state tyrosine-protein kinase abl1 (ABL1(Q252H)-nonphosphorylated) with mutation H252 in ABL1(Q252H)-nonphosphorylated in a nonphosphorylated state tyrosine-protein kinase abl1 (ABL1(Q252H)-phosphorylated) with mutation H252 in ABL1(Q252H)-phosphorylated in a phosphorylated state tyrosine-protein kinase abl1 (ABL1(T315I)-nonphosphorylated) with mutation I315 in ABL1(T315I)-nonphosphorylated in a nonphosphorylated state tyrosine-protein kinase abl1 (ABL1(T315I)-phosphorylated) with mutation I315 in ABL1(T315I)-phosphorylated in a phosphorylated state tyrosine-protein kinase abl1 (ABL1(Y253F)) with mutation F253 in ABL1(Y253F) in a nonphosphorylated state tyrosine-protein kinase abl1 (ABL1(Y253F)-phosphorylated) with mutation F253 in ABL1(Y253F)-phosphorylated in a phosphorylated state tyrosine-protein kinase abl1 (ABL1-nonphosphorylated) with no mutation in a nonphosphorylated state tyrosine-protein kinase abl1 (ABL1-phosphorylated) with no mutation in a phosphorylated state https://pharos.nih.gov/idg/targets/P00519 ABL1 ABL JTK7 P00519 Tyrosine-protein kinase abl1 dto:DTO_03100007 An Abelson tyrosine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42684] abelson tyrosine-protein kinase 2 (ABL2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P42684 ABL2 ABLL ARG P42684 Abelson tyrosine-protein kinase 2 dto:DTO_03100008 An activated CDC42 kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07912] activated cdc42 kinase 1 (TNK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q07912 TNK2 ACK1 Q07912 Activated cdc42 kinase 1 dto:DTO_03100009 An activin receptor type-1B that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36896] activin receptor type-1b (ACVR1B) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P36896 ACVR1B ACVRLK4 ALK4 P36896 Activin receptor type-1b dto:DTO_03100010 An activin receptor type-1C that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NER5] https://pharos.nih.gov/idg/targets/Q8NER5 ACVR1C ALK7 Q8NER5 Activin receptor type-1c dto:DTO_03100011 A serine/threonine-protein kinase receptor R3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P37023] serine/threonine-protein kinase receptor r3 (ACVRL1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P37023 ACVRL1 ACVRLK1 ALK1 P37023 Serine/threonine-protein kinase receptor r3 dto:DTO_03100012 An activin receptor type-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q04771] activin receptor type-1 (ACVR1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q04771 ACVR1 ACVRLK2 Q04771 Activin receptor type-1 dto:DTO_03100013 An uncharacterized aarF domain-containing protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86TW2] https://pharos.nih.gov/idg/targets/Q86TW2 ADCK1 Q86TW2 Uncharacterized aarf domain-containing protein kinase 1 dto:DTO_03100014 An uncharacterized aarF domain-containing protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z695] https://pharos.nih.gov/idg/targets/Q7Z695 ADCK2 AARF Q7Z695 Uncharacterized aarf domain-containing protein kinase 2 dto:DTO_03100015 A chaperone activity of bc1 complex-like, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NI60] Atypical kinase ADCK3, mitochondrial (ADCK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8NI60 ADCK3 CABC1 Q8NI60 Atypical kinase adck3, mitochondrial dto:DTO_03100016 An AarF domain-containing protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D53] aarf domain-containing protein kinase 4 (ADCK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q96D53 ADCK4 Q96D53 Aarf domain-containing protein kinase 4 dto:DTO_03100017 An uncharacterized aarF domain-containing protein kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q3MIX3] https://pharos.nih.gov/idg/targets/Q3MIX3 ADCK5 Q3MIX3 Uncharacterized aarf domain-containing protein kinase 5 dto:DTO_03100018 An adenosine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55263] https://pharos.nih.gov/idg/targets/P55263 ADK P55263 Adenosine kinase dto:DTO_03100019 A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31749] RAC-alpha serine/threonine-protein kinase (AKT1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P31749 AKT1 PKB RAC P31749 Rac-alpha serine/threonine-protein kinase dto:DTO_03100020 A RAC-beta serine/threonine-protein kinase that is encoded in the genome of human. [PRO:CNA, UniProtKB:P31751] RAC-beta serine/threonine-protein kinase (AKT2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P31751 AKT2 P31751 Rac-beta serine/threonine-protein kinase dto:DTO_03100021 A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y243] RAC-gamma serine/threonine-protein kinase (AKT3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y243 AKT3 PKBG Q9Y243 Rac-gamma serine/threonine-protein kinase dto:DTO_03100022 An ALK tyrosine kinase receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UM73] alk tyrosine kinase receptor (ALK(C1156Y)) with mutation Y1156 in ALK(C1156Y) in a nonphosphorylated state alk tyrosine kinase receptor (ALK(L1196M)) with mutation M1196 in ALK(L1196M) in a nonphosphorylated state alk tyrosine kinase receptor (ALK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UM73 ALK Q9UM73 Alk tyrosine kinase receptor dto:DTO_03100023 An alpha-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QP1] https://pharos.nih.gov/idg/targets/Q96QP1 ALPK1 KIAA1527 LAK Q96QP1 Alpha-protein kinase 1 dto:DTO_03100024 An alpha-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86TB3] https://pharos.nih.gov/idg/targets/Q86TB3 ALPK2 HAK Q86TB3 Alpha-protein kinase 2 dto:DTO_03100025 An alpha-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96L96] https://pharos.nih.gov/idg/targets/Q96L96 ALPK3 KIAA1330 MAK Q96L96 Alpha-protein kinase 3 dto:DTO_03100026 An anti-Muellerian hormone type-2 receptor that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16671] https://pharos.nih.gov/idg/targets/Q16671 AMHR2 AMHR MISR2 Q16671 Anti-muellerian hormone type-2 receptor dto:DTO_03100027 An ankyrin repeat and protein kinase domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFD2] ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8NFD2 ANKK1 PKK2 SGK288 Q8NFD2 Ankyrin repeat and protein kinase domain-containing protein 1 dto:DTO_03100028 An atrial natriuretic peptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16066] https://pharos.nih.gov/idg/targets/P16066 NPR1 ANPRA P16066 Atrial natriuretic peptide receptor 1 dto:DTO_03100029 An atrial natriuretic peptide receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20594] https://pharos.nih.gov/idg/targets/P20594 NPR2 ANPRB P20594 Atrial natriuretic peptide receptor 2 dto:DTO_03100030 A serine/threonine-protein kinase A-Raf that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10398] https://pharos.nih.gov/idg/targets/P10398 ARAF ARAF1 PKS PKS2 P10398 Serine/threonine-protein kinase a-raf dto:DTO_03100031 A beta-adrenergic receptor kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P25098] https://pharos.nih.gov/idg/targets/P25098 ADRBK1 BARK BARK1 GRK2 P25098 Beta-adrenergic receptor kinase 1 dto:DTO_03100032 A beta-adrenergic receptor kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35626] https://pharos.nih.gov/idg/targets/P35626 ADRBK2 BARK2 GRK3 P35626 Beta-adrenergic receptor kinase 2 dto:DTO_03100033 A serine-protein kinase ATM that is encoded in the genome of human. [PRO:CNA] https://pharos.nih.gov/idg/targets/Q13315 ATM Q13315 Serine-protein kinase atm dto:DTO_03100034 A serine/threonine-protein kinase ATR that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13535] https://pharos.nih.gov/idg/targets/Q13535 ATR FRP1 Q13535 Serine/threonine-protein kinase atr dto:DTO_03100035 An aurora kinase A that is encoded in the genome of human. [PRO:KER] aurora kinase a (AURKA) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O14965 AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 O14965 Aurora kinase a dto:DTO_03100036 An aurora kinase B that is encoded in the genome of human. [PMID:12719470, PMID:15592459, PMID:15917996, PMID:17617734, PMID:20624902, PMID:21658950, PMID:22732840, PRO:KER] aurora kinase b (AURKB) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q96GD4 AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5 Q96GD4 Aurora kinase b dto:DTO_03100037 An aurora kinase C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQB9] aurora kinase c (AURKC) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UQB9 AURKC AIE2 AIK3 AIRK3 ARK3 STK13 Q9UQB9 Aurora kinase c dto:DTO_03100038 An activin receptor type-2A that is encoded in the genome of human. [PRO:CNA, UniProtKB:P27037] activin receptor type-2a (ACVR2A) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P27037 ACVR2A ACVR2 P27037 Activin receptor type-2a dto:DTO_03100039 An activin receptor type-2B that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13705] activin receptor type-2b (ACVR2B) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13705 ACVR2B Q13705 Activin receptor type-2b dto:DTO_03100040 A [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14874] https://pharos.nih.gov/idg/targets/O14874 BCKDK O14874 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial dto:DTO_03100041 A tyrosine-protein kinase BLK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51451] tyrosine-protein kinase blk (BLK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P51451 BLK P51451 Tyrosine-protein kinase blk dto:DTO_03100042 A BMP-2-inducible protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSY1] BMP-2-inducible protein kinase (BIKE) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9NSY1 BMP2K BIKE Q9NSY1 Bmp-2-inducible protein kinase dto:DTO_03100043 A BMP receptor type-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13873] bone morphogenetic protein receptor type-2 (BMPR2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13873 BMPR2 PPH1 Q13873 Bone morphogenetic protein receptor type-2 dto:DTO_03100044 A BMP receptor type-1A that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36894] bone morphogenetic protein receptor type-1a (BMPR1A) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P36894 BMPR1A ACVRLK3 ALK3 P36894 Bone morphogenetic protein receptor type-1a dto:DTO_03100045 A BMP receptor type-1B that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00238] bone morphogenetic protein receptor type-1b (BMPR1B) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O00238 BMPR1B O00238 Bone morphogenetic protein receptor type-1b dto:DTO_03100046 A cytoplasmic tyrosine-protein kinase BMX that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51813] cytoplasmic tyrosine-protein kinase bmx (BMX) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P51813 BMX P51813 Cytoplasmic tyrosine-protein kinase bmx dto:DTO_03100047 A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15056] serine/threonine-protein kinase b-raf (BRAF(V600E)) with mutation E600 in BRAF(V600E) in a nonphosphorylated state serine/threonine-protein kinase b-raf (BRAF) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P15056 BRAF BRAF1 RAFB1 P15056 Serine/threonine-protein kinase b-raf dto:DTO_03100048 A serine/threonine-protein kinase BRSK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDC3] serine/threonine-protein kinase brsk1 (BRSK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8TDC3 BRSK1 KIAA1811 SAD1 SADB Q8TDC3 Serine/threonine-protein kinase brsk1 dto:DTO_03100049 A serine/threonine-protein kinase BRSK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWQ3] serine/threonine-protein kinase brsk2 (BRSK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8IWQ3 BRSK2 C11orf7 PEN11B SADA STK29 Q8IWQ3 Serine/threonine-protein kinase brsk2 dto:DTO_03100050 A tyrosine-protein kinase BTK that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q06187] tyrosine-protein kinase btk (BTK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q06187 BTK AGMX1 ATK BPK Q06187 Tyrosine-protein kinase btk dto:DTO_03100051 A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human. [Reactome:REACT_3972] https://pharos.nih.gov/idg/targets/O60566 BUB1B BUBR1 MAD3L SSK1 O60566 Mitotic checkpoint serine/threonine-protein kinase bub1 beta dto:DTO_03100052 A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human. [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER] mitotic checkpoint serine/threonine-protein kinase bub1 (BUB1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O43683 BUB1 BUB1L O43683 Mitotic checkpoint serine/threonine-protein kinase bub1 dto:DTO_03100053 A CaM kinase-like vesicle-associated protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NCB2] https://pharos.nih.gov/idg/targets/Q8NCB2 CAMKV Q8NCB2 Cam kinase-like vesicle-associated protein dto:DTO_03100054 A cyclin-dependent kinase 11A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQ88] cyclin-dependent kinase 11a (CDC2L2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UQ88 CDK11A CDC2L2 CDC2L3 PITSLREB Q9UQ88 Cyclin-dependent kinase 11a dto:DTO_03100055 A cyclin-dependent kinase 11B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21127] cyclin-dependent kinase 11b (CDC2L1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P21127 CDK11B CDC2L1 CDK11 PITSLREA PK58 P21127 Cyclin-dependent kinase 11b dto:DTO_03100056 A cell division cycle 7-related protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00311] https://pharos.nih.gov/idg/targets/O00311 CDC7 CDC7L1 O00311 Cell division cycle 7-related protein kinase dto:DTO_03100057 A cyclin-dependent kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15131] https://pharos.nih.gov/idg/targets/Q15131 CDK10 Q15131 Cyclin-dependent kinase 10 dto:DTO_03100058 A cyclin-dependent kinase 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV4] https://pharos.nih.gov/idg/targets/Q9NYV4 CDK12 CRK7 CRKRS KIAA0904 Q9NYV4 Cyclin-dependent kinase 12 dto:DTO_03100059 A cyclin-dependent kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14004] cyclin-dependent kinase 13 (CDC2L5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q14004 CDK13 CDC2L CDC2L5 CHED KIAA1791 Q14004 Cyclin-dependent kinase 13 dto:DTO_03100060 A cyclin-dependent kinase 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94921] cyclin-dependent kinase 14 (CDK14) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O94921 CDK14 KIAA0834 PFTK1 O94921 Cyclin-dependent kinase 14 dto:DTO_03100061 A cyclin-dependent kinase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q40] cyclin-dependent kinase 15 (CDK15) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q96Q40 CDK15 ALS2CR7 PFTK2 Q96Q40 Cyclin-dependent kinase 15 dto:DTO_03100062 A cyclin-dependent kinase 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00536] cyclin-dependent kinase 16 (CDK16) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q00536 CDK16 PCTAIRE1 PCTK1 Q00536 Cyclin-dependent kinase 16 dto:DTO_03100063 A cyclin-dependent kinase 17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00537] cyclin-dependent kinase 17 (PCTK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q00537 CDK17 PCTAIRE2 PCTK2 Q00537 Cyclin-dependent kinase 17 dto:DTO_03100064 A cyclin-dependent kinase 18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07002] cyclin-dependent kinase 18 (PCTK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q07002 CDK18 PCTAIRE3 PCTK3 Q07002 Cyclin-dependent kinase 18 dto:DTO_03100065 A cyclin-dependent kinase 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BWU1] cyclin-dependent kinase 19 (CDK11) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9BWU1 CDK19 CDC2L6 CDK11 KIAA1028 Q9BWU1 Cyclin-dependent kinase 19 dto:DTO_03100066 A cell division protein kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P06493] https://pharos.nih.gov/idg/targets/P06493 CDK1 CDC2 CDC28A CDKN1 P34CDC2 P06493 Cyclin-dependent kinase 1 dto:DTO_03100067 A cyclin-dependent kinase 20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZL9] https://pharos.nih.gov/idg/targets/Q8IZL9 CDK20 CCRK CDCH Q8IZL9 Cyclin-dependent kinase 20 dto:DTO_03100068 A cyclin-dependent kinase 2 that is encoded in the genome of human. cyclin-dependent kinase 2 (CDK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P24941 CDK2 CDKN2 P24941 Cyclin-dependent kinase 2 dto:DTO_03100069 A cyclin-dependent kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00526] cyclin-dependent kinase 3 (CDK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q00526 CDK3 CDKN3 Q00526 Cyclin-dependent kinase 3 dto:DTO_03100070 A cell division protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11802] cyclin-dependent kinase 4 (CDK4-cyclinD1) with no mutation in a nonphosphorylated state cyclin-dependent kinase 4 (CDK4-cyclinD3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P11802 CDK4 P11802 Cyclin-dependent kinase 4 dto:DTO_03100071 A cell division protein kinase 5 that is encoded in the genome of human. cyclin-dependent-like kinase 5 (CDK5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q00535 CDK5 CDKN5 Q00535 Cyclin-dependent-like kinase 5 dto:DTO_03100072 A cyclin-dependent kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00534] https://pharos.nih.gov/idg/targets/Q00534 CDK6 CDKN6 Q00534 Cyclin-dependent kinase 6 dto:DTO_03100073 A cell division protein kinase 7 that is encoded in the genome of human. cyclin-dependent kinase 7 (CDK7) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P50613 CDK7 CAK CAK1 CDKN7 MO15 STK1 P50613 Cyclin-dependent kinase 7 dto:DTO_03100074 A cyclin-dependent kinase 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49336] cyclin-dependent kinase 8 (CDK8) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P49336 CDK8 P49336 Cyclin-dependent kinase 8 dto:DTO_03100075 A cyclin-dependent kinase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50750] cyclin-dependent kinase 9 (CDK9) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P50750 CDK9 CDC2L4 TAK P50750 Cyclin-dependent kinase 9 dto:DTO_03100076 A cyclin-dependent kinase-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00532] cyclin-dependent kinase-like 1 (CDKL1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q00532 CDKL1 Q00532 Cyclin-dependent kinase-like 1 dto:DTO_03100077 A cyclin-dependent kinase-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92772] cyclin-dependent kinase-like 2 (CDKL2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q92772 CDKL2 Q92772 Cyclin-dependent kinase-like 2 dto:DTO_03100078 A cyclin-dependent kinase-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IVW4] cyclin-dependent kinase-like 3 (CDKL3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8IVW4 CDKL3 NKIAMRE Q8IVW4 Cyclin-dependent kinase-like 3 dto:DTO_03100079 A cyclin-dependent kinase-like 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5MAI5] https://pharos.nih.gov/idg/targets/Q5MAI5 CDKL4 Q5MAI5 Cyclin-dependent kinase-like 4 dto:DTO_03100080 A cyclin-dependent kinase-like 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76039] cyclin-dependent kinase-like 5 (CDKL5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O76039 CDKL5 STK9 O76039 Cyclin-dependent kinase-like 5 dto:DTO_03100081 A ceramide kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCT0] https://pharos.nih.gov/idg/targets/Q8TCT0 CERK KIAA1646 Q8TCT0 Ceramide kinase dto:DTO_03100082 A serine/threonine-protein kinase CHK1 that is encoded in the genome of humans. [PRO:CNA] serine/threonine-protein kinase chk1 (CHEK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O14757 CHEK1 CHK1 O14757 Serine/threonine-protein kinase chk1 dto:DTO_03100083 A serine/threonine-protein kinase Chk2 that is encoded in the genome of human. [OMA:HUMAN19404, PRO:DNx] serine/threonine-protein kinase chk2 (CHK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O96017 CHEK2 CDS1 CHK2 RAD53 O96017 Serine/threonine-protein kinase chk2 dto:DTO_03100084 A choline kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35790] https://pharos.nih.gov/idg/targets/P35790 CHKA CHK CKI P35790 Choline kinase alpha dto:DTO_03100085 A choline/ethanolamine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y259] https://pharos.nih.gov/idg/targets/Q9Y259 CHKB CHETK CHKL Q9Y259 Choline/ethanolamine kinase dto:DTO_03100086 A dual specificity protein kinase CLK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49759] dual specificity protein kinase clk1 (CLK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P49759 CLK1 CLK P49759 Dual specificity protein kinase clk1 dto:DTO_03100087 A dual specificity protein kinase CLK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49760] dual specificity protein kinase clk2 (CLK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P49760 CLK2 P49760 Dual specificity protein kinase clk2 dto:DTO_03100088 A dual specificity protein kinase CLK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49761] dual specificity protein kinase clk3 (CLK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P49761 CLK3 P49761 Dual specificity protein kinase clk3 dto:DTO_03100089 A dual specificity protein kinase CLK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HAZ1] dual specificity protein kinase clk4 (CLK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9HAZ1 CLK4 Q9HAZ1 Dual specificity protein kinase clk4 dto:DTO_03100090 A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07333] macrophage colony-stimulating factor 1 receptor (CSF1R) with no mutation in a nonphosphorylated state macrophage colony-stimulating factor 1 receptor (CSF1R-autoinhibited) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P07333 CSF1R FMS P07333 Macrophage colony-stimulating factor 1 receptor dto:DTO_03100091 A casein kinase II subunit alpha' that is encoded in the genome of human. casein kinase ii subunit alpha (CSNK2A1) with no mutation in a nonphosphorylated state casein kinase ii subunit alpha (CSNK2A2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P68400 CSNK2A1 CK2A1 P68400 Casein kinase II subunit alpha dto:DTO_03100092 A casein kinase II subunit alpha' that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/P19784 CSNK2A2 CK2A2 P19784 Casein kinase II subunit alpha' dto:DTO_03100093 A protein that is a translation product of the human CSNK2A3 gene. [PRO:DNx, UniProtKB:Q8NEV1] https://pharos.nih.gov/idg/targets/Q8NEV1 CSNK2A3 CSNK2A1P Q8NEV1 Casein kinase ii subunit alpha 3 dto:DTO_03100094 A casein kinase II subunit beta that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/P67870 CSNK2B CK2N G5A P67870 Casein kinase ii subunit beta dto:DTO_03100095 A peripheral plasma membrane protein CASK that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_24832] peripheral plasma membrane protein cask (CASK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O14936 CASK LIN2 O14936 Peripheral plasma membrane protein cask dto:DTO_03100096 A tyrosine-protein kinase CSK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41240] tyrosine-protein kinase csk (CSK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P41240 CSK P41240 Tyrosine-protein kinase csk dto:DTO_03100097 A citron Rho-interacting kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14578] citron rho-interacting kinase (CIT) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O14578 CIT CRIK KIAA0949 STK21 O14578 Citron rho-interacting kinase dto:DTO_03100098 A death-associated protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53355] death-associated protein kinase 1 (DAPK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P53355 DAPK1 DAPK P53355 Death-associated protein kinase 1 dto:DTO_03100099 A death-associated protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UIK4] death-associated protein kinase 2 (DAPK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UIK4 DAPK2 Q9UIK4 Death-associated protein kinase 2 dto:DTO_03100100 A death-associated protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43293] death-associated protein kinase 3 (DAPK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O43293 DAPK3 ZIPK O43293 Death-associated protein kinase 3 dto:DTO_03100101 A deoxycytidine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27707] https://pharos.nih.gov/idg/targets/P27707 DCK P27707 Deoxycytidine kinase dto:DTO_03100102 A serine/threonine-protein kinase DCLK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15075] serine/threonine-protein kinase dclk1 (DCLK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O15075 DCLK1 DCAMKL1 DCDC3A KIAA0369 O15075 Serine/threonine-protein kinase dclk1 dto:DTO_03100103 A serine/threonine-protein kinase DCLK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N568] serine/threonine-protein kinase dclk2 (DCAMKL2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8N568 DCLK2 DCAMKL2 DCDC3B DCK2 Q8N568 Serine/threonine-protein kinase dclk2 dto:DTO_03100104 A serine/threonine-protein kinase DCLK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C098] serine/threonine-protein kinase dclk3 (DCAMKL3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9C098 DCLK3 DCAMKL3 DCDC3C KIAA1765 Q9C098 Serine/threonine-protein kinase dclk3 dto:DTO_03100105 A discoidin domain-containing receptor 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q08345] epithelial discoidin domain-containing receptor 1 (DDR1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q08345 DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE Q08345 Epithelial discoidin domain-containing receptor 1 dto:DTO_03100106 A discoidin domain-containing receptor 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16832] discoidin domain-containing receptor 2 (DDR2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16832 DDR2 NTRKR3 TKT TYRO10 Q16832 Discoidin domain-containing receptor 2 dto:DTO_03100107 A diacylglycerol kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23743] https://pharos.nih.gov/idg/targets/P23743 DGKA DAGK DAGK1 P23743 Diacylglycerol kinase alpha dto:DTO_03100108 A diacylglycerol kinase eta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86XP1] https://pharos.nih.gov/idg/targets/Q86XP1 DGKH Q86XP1 Diacylglycerol kinase eta dto:DTO_03100109 A diacylglycerol kinase theta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52824] https://pharos.nih.gov/idg/targets/P52824 DGKQ DAGK4 P52824 Diacylglycerol kinase theta dto:DTO_03100110 A deoxyguanosine kinase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16854] https://pharos.nih.gov/idg/targets/Q16854 DGUOK DGK Q16854 Deoxyguanosine kinase, mitochondrial dto:DTO_03100111 A myotonin-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09013] myotonin-protein kinase (DMPK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q09013 DMPK DM1PK MDPK Q09013 Myotonin-protein kinase dto:DTO_03100112 A dual serine/threonine and tyrosine protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6XUX3] dual serine/threonine and tyrosine protein kinase (RIPK5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q6XUX3 DSTYK KIAA0472 RIP5 RIPK5 SGK496 Q6XUX3 Dual serine/threonine and tyrosine protein kinase dto:DTO_03100113 A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13627] dual specificity tyrosine-phosphorylation-regulated kinase 1a (DYRK1A) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13627 DYRK1A DYRK MNB MNBH Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1a dto:DTO_03100114 A dual specificity tyrosine-phosphorylation-regulated kinase 1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y463] dual specificity tyrosine-phosphorylation-regulated kinase 1b (DYRK1B) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y463 DYRK1B MIRK Q9Y463 Dual specificity tyrosine-phosphorylation-regulated kinase 1b dto:DTO_03100115 A dual specificity tyrosine-phosphorylation-regulated kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92630] dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q92630 DYRK2 Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 dto:DTO_03100116 A dual specificity tyrosine-phosphorylation-regulated kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43781] https://pharos.nih.gov/idg/targets/O43781 DYRK3 O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 dto:DTO_03100117 A dual specificity tyrosine-phosphorylation-regulated kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NR20] https://pharos.nih.gov/idg/targets/Q9NR20 DYRK4 Q9NR20 Dual specificity tyrosine-phosphorylation-regulated kinase 4 dto:DTO_03100118 A eukaryotic translation initiation factor 2-alpha kinase 1 that is encoded in the genome of human. eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9BQI3 EIF2AK1 HRI KIAA1369 Q9BQI3 Eukaryotic translation initiation factor 2-alpha kinase 1 dto:DTO_03100119 An interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19525] interferon-induced, double-stranded rna-activated protein kinase (PRKR) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P19525 EIF2AK2 PKR PRKR P19525 Interferon-induced, double-stranded rna-activated protein kinase dto:DTO_03100120 A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_18737] https://pharos.nih.gov/idg/targets/Q9NZJ5 EIF2AK3 PEK PERK Q9NZJ5 Eukaryotic translation initiation factor 2-alpha kinase 3 dto:DTO_03100121 A eukaryotic translation initiation factor 2-alpha kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P2K8] eukaryotic translation initiation factor 2-alpha kinase 4 (GCN2(Kin.Dom.2,S808G)) with mutation G808 in GCN2(Kin.Dom.2,S808G) in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9P2K8 EIF2AK4 GCN2 KIAA1338 Q9P2K8 Eukaryotic translation initiation factor 2-alpha kinase 4 dto:DTO_03100122 An elongation factor 2 kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00418] https://pharos.nih.gov/idg/targets/O00418 EEF2K O00418 Eukaryotic elongation factor 2 kinase dto:DTO_03100123 An ephrin-A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20827] https://pharos.nih.gov/idg/targets/P20827 EFNA1 EPLG1 LERK1 TNFAIP4 P20827 Ephrin-a1 dto:DTO_03100124 An epidermal growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00533] epidermal growth factor receptor (EGFR(E746-A750del)) with mutation A746-A750del in EGFR(E746-A750del) in a nonphosphorylated state epidermal growth factor receptor (EGFR(G719C)) with mutation C719 in EGFR(G719C) in a nonphosphorylated state epidermal growth factor receptor (EGFR(G719S)) with mutation S719 in EGFR(G719S) in a nonphosphorylated state epidermal growth factor receptor (EGFR(L747-E749del, A750P)) with mutation L747-E749del and P750 in EGFR(L747-E749del, A750P) in a nonphosphorylated state epidermal growth factor receptor (EGFR(L747-S752del, P753S)) with mutation L747-S752del and S753 in EGFR(L747-S752del, P753S) in a nonphosphorylated state epidermal growth factor receptor (EGFR(L747-T751del,Sins)) with mutation T747-T751del and Silenced in EGFR(L747-T751del,Sins) in a nonphosphorylated state epidermal growth factor receptor (EGFR(L858R)) with mutation R858 in EGFR(L858R) in a nonphosphorylated state epidermal growth factor receptor (EGFR(L858R,T790M)) with mutation R858 and M790 in EGFR(L858R,T790M) in a nonphosphorylated state epidermal growth factor receptor (EGFR(L861Q)) with mutation Q861 in EGFR(L861Q) in a nonphosphorylated state epidermal growth factor receptor (EGFR(S752-I759del)) with mutation S752-I759del in EGFR(S752-I759del) in a nonphosphorylated state epidermal growth factor receptor (EGFR(T790M)) with mutation M790 in EGFR(T790M) in a nonphosphorylated state epidermal growth factor receptor (EGFR) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P00533 EGFR ERBB ERBB1 HER1 P00533 Epidermal growth factor receptor dto:DTO_03100125 An ephrin type-A receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21709] ephrin type-a receptor 1 (EPHA1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P21709 EPHA1 EPH EPHT EPHT1 P21709 Ephrin type-a receptor 1 dto:DTO_03100126 An ephrin type-A receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29317] ephrin type-a receptor 2 (EPHA2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P29317 EPHA2 ECK P29317 Ephrin type-a receptor 2 dto:DTO_03100127 An ephrin type-A receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29320] ephrin type-a receptor 3 (EPHA3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P29320 EPHA3 ETK ETK1 HEK TYRO4 P29320 Ephrin type-a receptor 3 dto:DTO_03100128 An ephrin type-A receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54764] ephrin type-a receptor 4 (EPHA4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P54764 EPHA4 HEK8 SEK TYRO1 P54764 Ephrin type-a receptor 4 dto:DTO_03100129 An ephrin type-A receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54756] ephrin type-a receptor 5 (EPHA5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P54756 EPHA5 BSK EHK1 HEK7 TYRO4 P54756 Ephrin type-a receptor 5 dto:DTO_03100130 An ephrin type-A receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UF33] ephrin type-a receptor 6 (EPHA6) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UF33 EPHA6 EHK2 HEK12 Q9UF33 Ephrin type-a receptor 6 dto:DTO_03100131 An ephrin type-A receptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15375] ephrin type-a receptor 7 (EPHA7) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15375 EPHA7 EHK3 HEK11 Q15375 Ephrin type-a receptor 7 dto:DTO_03100132 An ephrin type-A receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29322] ephrin type-a receptor 8 (EPHA8) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P29322 EPHA8 EEK HEK3 KIAA1459 P29322 Ephrin type-a receptor 8 dto:DTO_03100133 An ephrin type-A receptor 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JZY3] https://pharos.nih.gov/idg/targets/Q5JZY3 EPHA10 Q5JZY3 Ephrin type-a receptor 10 dto:DTO_03100134 An ephrin type-B receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54762] ephrin type-b receptor 1 (EPHB1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P54762 EPHB1 ELK EPHT2 HEK6 NET P54762 Ephrin type-b receptor 1 dto:DTO_03100135 An ephrin type-B receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29323] ephrin type-b receptor 2 (EPHB2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P29323 EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5 P29323 Ephrin type-b receptor 2 dto:DTO_03100136 An ephrin type-B receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54753] ephrin type-b receptor 3 (EPHB3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P54753 EPHB3 ETK2 HEK2 TYRO6 P54753 Ephrin type-b receptor 3 dto:DTO_03100137 An ephrin type-B receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54760] ephrin type-b receptor 4 (EPHB4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P54760 EPHB4 HTK MYK1 TYRO11 P54760 Ephrin type-b receptor 4 dto:DTO_03100138 An ephrin type-B receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15197] ephrin type-b receptor 6 (EPHB6) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O15197 EPHB6 O15197 Ephrin type-b receptor 6 dto:DTO_03100139 A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04626] receptor tyrosine-protein kinase erbb-2 (ERBB2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P04626 ERBB2 HER2 MLN19 NEU NGL P04626 Receptor tyrosine-protein kinase erbb-2 dto:DTO_03100140 A receptor tyrosine-protein kinase erbB-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21860] receptor tyrosine-protein kinase erbb-3 (ERBB3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P21860 ERBB3 HER3 P21860 Receptor tyrosine-protein kinase erbb-3 dto:DTO_03100141 A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15303] receptor tyrosine-protein kinase erbb-4 (ERBB4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15303 ERBB4 HER4 Q15303 Receptor tyrosine-protein kinase erbb-4 dto:DTO_03100142 A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human. [Reactome:REACT_18666] serine/threonine-protein kinase/endoribonuclease ire1 (ERN1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O75460 ERN1 IRE1 O75460 Serine/threonine-protein kinase/endoribonuclease ire1 dto:DTO_03100143 A serine/threonine-protein kinase/endoribonuclease IRE2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q76MJ5] https://pharos.nih.gov/idg/targets/Q76MJ5 ERN2 IRE2 Q76MJ5 Serine/threonine-protein kinase/endoribonuclease ire2 dto:DTO_03100144 A focal adhesion kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q05397] focal adhesion kinase 1 (FAK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q05397 PTK2 FAK FAK1 Q05397 Focal adhesion kinase 1 dto:DTO_03100145 A focal adhesion kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q14289] protein-tyrosine kinase 2-beta (FAK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q14289 PTK2B FAK2 PYK2 RAFTK Q14289 Protein-tyrosine kinase 2-beta dto:DTO_03100146 A Fas-activated serine/threonine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14296] https://pharos.nih.gov/idg/targets/Q14296 FASTK Q14296 Fas-activated serine/threonine kinase dto:DTO_03100147 A tyrosine-protein kinase Fer that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16591] tyrosine-protein kinase fer (FER) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P16591 FER TYK3 P16591 Tyrosine-protein kinase fer dto:DTO_03100148 A tyrosine-protein kinase Fes/Fps that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07332] tyrosine-protein kinase fes/fps (FES) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P07332 FES FPS P07332 Tyrosine-protein kinase fes/fps dto:DTO_03100149 A basic fibroblast growth factor receptor 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P11362] fibroblast growth factor receptor 1 (FGFR1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P11362 FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR P11362 Fibroblast growth factor receptor 1 dto:DTO_03100150 A fibroblast growth factor receptor 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P21802] fibroblast growth factor receptor 2 (FGFR2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P21802 FGFR2 BEK KGFR KSAM P21802 Fibroblast growth factor receptor 2 dto:DTO_03100151 A fibroblast growth factor receptor 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P22607] fibroblast growth factor receptor 3 (FGFR3(G697C)) with mutation C697 in FGFR3(G697C) in a nonphosphorylated state fibroblast growth factor receptor 3 (FGFR3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P22607 FGFR3 JTK4 P22607 Fibroblast growth factor receptor 3 dto:DTO_03100152 A fibroblast growth factor receptor 4 that is encoded in the genome of human. [PRO:CNA] fibroblast growth factor receptor 4 (FGFR4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P22455 FGFR4 JTK2 TKF P22455 Fibroblast growth factor receptor 4 dto:DTO_03100153 A tyrosine-protein kinase Fgr that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09769] tyrosine-protein kinase fgr (FGR) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P09769 FGR SRC2 P09769 Tyrosine-protein kinase fgr dto:DTO_03100154 A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P36888] receptor-type tyrosine-protein kinase flt3 (FLT3(D835H)) with mutation H835 in FLT3(D835H) in a nonphosphorylated state receptor-type tyrosine-protein kinase flt3 (FLT3(D835Y)) with mutation Y835 in FLT3(D835Y) in a nonphosphorylated state receptor-type tyrosine-protein kinase flt3 (FLT3(ITD)) with mutation ITD in FLT3(ITD) in a nonphosphorylated state receptor-type tyrosine-protein kinase flt3 (FLT3(K663Q)) with mutation Q663 in FLT3(K663Q) in a nonphosphorylated state receptor-type tyrosine-protein kinase flt3 (FLT3(N841I)) with mutation I841 in FLT3(N841I) in a nonphosphorylated state receptor-type tyrosine-protein kinase flt3 (FLT3(R834Q)) with mutation Q834 in FLT3(R834Q) in a nonphosphorylated state receptor-type tyrosine-protein kinase flt3 (FLT3) with no mutation in a nonphosphorylated state receptor-type tyrosine-protein kinase flt3 (FLT3-autoinhibited) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P36888 FLT3 CD135 FLK2 STK1 P36888 Receptor-type tyrosine-protein kinase flt3 dto:DTO_03100155 A tyrosine-protein kinase FRK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42685] tyrosine-protein kinase frk (FRK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P42685 FRK PTK5 RAK P42685 Tyrosine-protein kinase frk dto:DTO_03100156 A tyrosine-protein kinase Fyn that is encoded in the genome of human. [PRO:CNA, UniProtKB:P06241] tyrosine-protein kinase fyn (FYN) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P06241 FYN P06241 Tyrosine-protein kinase fyn dto:DTO_03100157 A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2I7] https://pharos.nih.gov/idg/targets/Q9Y2I7 PIKFYVE KIAA0981 PIP5K3 Q9Y2I7 1-phosphatidylinositol 3-phosphate 5-kinase dto:DTO_03100158 A cyclin-G-associated kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14976] cyclin-g-associated kinase (GAK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O14976 GAK O14976 Cyclin-g-associated kinase dto:DTO_03100159 A glycerol kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14410] https://pharos.nih.gov/idg/targets/Q14410 GK2 GKP2 GKTA Q14410 Glycerol kinase 2 dto:DTO_03100160 A G protein-coupled receptor kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32298] G protein-coupled receptor kinase 4 (GRK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P32298 GRK4 GPRK2L GPRK4 P32298 G protein-coupled receptor kinase 4 dto:DTO_03100161 A G protein-coupled receptor kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34947] https://pharos.nih.gov/idg/targets/P34947 GRK5 GPRK5 P34947 G protein-coupled receptor kinase 5 dto:DTO_03100162 A G protein-coupled receptor kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43250] https://pharos.nih.gov/idg/targets/P43250 GRK6 GPRK6 P43250 G protein-coupled receptor kinase 6 dto:DTO_03100163 A G protein-coupled receptor kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WTQ7] G protein-coupled receptor kinase 7 (GRK7) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8WTQ7 GRK7 GPRK7 Q8WTQ7 G protein-coupled receptor kinase 7 dto:DTO_03100164 A glycogen synthase kinase-3 alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49840] glycogen synthase kinase-3 alpha (GSK3A) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P49840 GSK3A P49840 Glycogen synthase kinase-3 alpha dto:DTO_03100165 A glycogen synthase kinase-3 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49841] glycogen synthase kinase-3 beta (GSK3B) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P49841 GSK3B P49841 Glycogen synthase kinase-3 beta dto:DTO_03100166 A heat-stable enterotoxin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P25092] https://pharos.nih.gov/idg/targets/P25092 GUCY2C GUC2C STAR P25092 Heat-stable enterotoxin receptor dto:DTO_03100167 A retinal guanylyl cyclase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02846] https://pharos.nih.gov/idg/targets/Q02846 GUCY2D CORD6 GUC1A4 GUC2D RETGC RETGC1 Q02846 Retinal guanylyl cyclase 1 dto:DTO_03100168 A retinal guanylyl cyclase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51841] https://pharos.nih.gov/idg/targets/P51841 GUCY2F GUC2F RETGC2 P51841 Retinal guanylyl cyclase 2 dto:DTO_03100169 A microtubule-associated serine/threonine-protein kinase-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96GX5] https://pharos.nih.gov/idg/targets/Q96GX5 MASTL GW GWL THC2 Q96GX5 Serine/threonine-protein kinase greatwall dto:DTO_03100170 A serine/threonine-protein kinase haspin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TF76] serine/threonine-protein kinase haspin (HASP) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8TF76 GSG2 Q8TF76 Serine/threonine-protein kinase haspin dto:DTO_03100171 A tyrosine-protein kinase HCK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08631] tyrosine-protein kinase hck (HCK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P08631 HCK P08631 Tyrosine-protein kinase hck dto:DTO_03100172 A homeodomain-interacting protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Z02] homeodomain-interacting protein kinase 1 (HIPK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q86Z02 HIPK1 KIAA0630 MYAK NBAK2 Q86Z02 Homeodomain-interacting protein kinase 1 dto:DTO_03100173 A homeodomain-interacting protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2X6] homeodomain-interacting protein kinase 2 (HIPK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H2X6 HIPK2 Q9H2X6 Homeodomain-interacting protein kinase 2 dto:DTO_03100174 A homeodomain-interacting protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H422] homeodomain-interacting protein kinase 3 (HIPK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H422 HIPK3 DYRK6 FIST3 PKY Q9H422 Homeodomain-interacting protein kinase 3 dto:DTO_03100175 A homeodomain-interacting protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NE63] homeodomain-interacting protein kinase 4 (HIPK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8NE63 HIPK4 Q8NE63 Homeodomain-interacting protein kinase 4 dto:DTO_03100176 A hormonally up-regulated neu tumor-associated kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57058] hormonally up-regulated neu tumor-associated kinase (HUNK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P57058 HUNK MAKV P57058 Hormonally up-regulated neu tumor-associated kinase dto:DTO_03100177 A hexokinase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19367] https://pharos.nih.gov/idg/targets/P19367 HK1 P19367 Hexokinase-1 dto:DTO_03100178 A glucokinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35557] https://pharos.nih.gov/idg/targets/P35557 GCK P35557 Glucokinase dto:DTO_03100179 A serine/threonine-protein kinase ICK that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UPZ9] serine/threonine-protein kinase ick (ICK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UPZ9 ICK KIAA0936 Q9UPZ9 Serine/threonine-protein kinase ick dto:DTO_03100180 An insulin-like growth factor 1 receptor that is encoded in the genome of human. [PRO:JAN, UniProtKB:P08069] insulin-like growth factor 1 receptor (IGF1R) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P08069 IGF1R P08069 Insulin-like growth factor 1 receptor dto:DTO_03100181 An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15111] inhibitor of nuclear factor kappa-b kinase subunit alpha (IKKA) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O15111 CHUK IKKA TCF16 O15111 Inhibitor of nuclear factor kappa-b kinase subunit alpha dto:DTO_03100182 An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14920] inhibitor of nuclear factor kappa-b kinase subunit beta (IKKB) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O14920 IKBKB IKKB O14920 Inhibitor of nuclear factor kappa-b kinase subunit beta dto:DTO_03100183 An inhibitor of nuclear factor kappa-B kinase subunit epsilon encoded in the genome of human. [PMID:10882136, PMID:17327220, PRO:CNA, Reactome:REACT_21591] inhibitor of nuclear factor kappa-b kinase subunit epsilon (IKKE) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q14164 IKBKE IKKE IKKI KIAA0151 Q14164 Inhibitor of nuclear factor kappa-b kinase subunit epsilon dto:DTO_03100184 An integrin-linked protein kinase that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q13418 ILK ILK1 ILK2 Q13418 Integrin-linked protein kinase dto:DTO_03100185 An insulin receptor-related protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14616] insulin receptor-related protein (INSRR) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P14616 INSRR IRR P14616 Insulin receptor-related protein dto:DTO_03100186 An insulin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06213] insulin receptor (INSR) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P06213 INSR P06213 Insulin receptor dto:DTO_03100187 An inositol-trisphosphate 3-kinase A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23677] https://pharos.nih.gov/idg/targets/P23677 ITPKA P23677 Inositol-trisphosphate 3-kinase a dto:DTO_03100188 An inositol-trisphosphate 3-kinase B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27987] https://pharos.nih.gov/idg/targets/P27987 ITPKB P27987 Inositol-trisphosphate 3-kinase b dto:DTO_03100189 An inositol polyphosphate multikinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU5] https://pharos.nih.gov/idg/targets/Q8NFU5 IPMK IMPK Q8NFU5 Inositol polyphosphate multikinase dto:DTO_03100190 An interleukin-1 receptor-associated kinase 1 encoded in the genome of human. [PRO:CNA] interleukin-1 receptor-associated kinase 1 (IRAK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P51617 IRAK1 IRAK P51617 Interleukin-1 receptor-associated kinase 1 dto:DTO_03100191 An interleukin-1 receptor-associated kinase-like 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O43187] https://pharos.nih.gov/idg/targets/O43187 IRAK2 O43187 Interleukin-1 receptor-associated kinase-like 2 dto:DTO_03100192 An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y616] interleukin-1 receptor-associated kinase 3 (IRAK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y616 IRAK3 Q9Y616 Interleukin-1 receptor-associated kinase 3 dto:DTO_03100193 An interleukin-1 receptor-associated kinase 4 encoded in the genome of human. [PRO:CNA] interleukin-1 receptor-associated kinase 4 (IRAK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9NWZ3 IRAK4 Q9NWZ3 Interleukin-1 receptor-associated kinase 4 dto:DTO_03100194 A tyrosine-protein kinase ITK/TSK that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q08881] tyrosine-protein kinase itk/tsk (ITK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q08881 ITK EMT LYK Q08881 Tyrosine-protein kinase itk/tsk dto:DTO_03100195 An inositol-tetrakisphosphate 1-kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13572] https://pharos.nih.gov/idg/targets/Q13572 ITPK1 Q13572 Inositol-tetrakisphosphate 1-kinase dto:DTO_03100196 A tyrosine-protein kinase JAK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23458] tyrosine-protein kinase jak1 (JAK1(Kin.Dom.1)) with no mutation in a nonphosphorylated state tyrosine-protein kinase jak1 (JAK1(Kin.Dom.2)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P23458 JAK1 JAK1A JAK1B P23458 Tyrosine-protein kinase jak1 dto:DTO_03100197 A tyrosine-protein kinase JAK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60674] tyrosine-protein kinase jak2 (JAK2(JH1domain-catalytic)) with no mutation in a nonphosphorylated state tyrosine-protein kinase jak2 (JAK2(Kin.Dom.2)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O60674 JAK2 O60674 Tyrosine-protein kinase jak2 dto:DTO_03100198 A tyrosine-protein kinase JAK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52333] tyrosine-protein kinase jak3 (JAK3(JH1domain-catalytic)) with no mutation in a nonphosphorylated state tyrosine-protein kinase jak3 (JAK3(Kin.Dom.2)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P52333 JAK3 P52333 Tyrosine-protein kinase jak3 dto:DTO_03100199 A 6-phosphofructokinase, liver type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17858] https://pharos.nih.gov/idg/targets/P17858 PFKL P17858 Atp-dependent 6-phosphofructokinase, liver type dto:DTO_03100200 An adenylate kinase isoenzyme 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00568] https://pharos.nih.gov/idg/targets/P00568 AK1 P00568 Adenylate kinase isoenzyme 1 dto:DTO_03100201 An adenylate kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54819] https://pharos.nih.gov/idg/targets/P54819 AK2 ADK2 P54819 Adenylate kinase 2, mitochondrial dto:DTO_03100202 A GTP:AMP phosphotransferase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UIJ7] https://pharos.nih.gov/idg/targets/Q9UIJ7 AK3 AK3L1 AK6 AKL3L Q9UIJ7 Gtp:amp phosphotransferase ak3, mitochondrial dto:DTO_03100203 A kalirin that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60229] https://pharos.nih.gov/idg/targets/O60229 KALRN DUET DUO HAPIP TRAD O60229 Kalirin dto:DTO_03100204 A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17612] camp-dependent protein kinase catalytic subunit alpha (PKAC-alpha) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P17612 PRKACA PKACA P17612 Camp-dependent protein kinase catalytic subunit alpha dto:DTO_03100205 A cAMP-dependent protein kinase catalytic subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22694] camp-dependent protein kinase catalytic subunit beta (PKAC-beta) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P22694 PRKACB P22694 Camp-dependent protein kinase catalytic subunit beta dto:DTO_03100206 A cAMP-dependent protein kinase catalytic subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22612] https://pharos.nih.gov/idg/targets/P22612 PRKACG P22612 Camp-dependent protein kinase catalytic subunit gamma dto:DTO_03100207 A casein kinase I isoform alpha-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N752] casein kinase i isoform alpha-like (CSNK1A1L) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8N752 CSNK1A1L Q8N752 Casein kinase i isoform alpha-like dto:DTO_03100208 A casein kinase I isoform alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48729] casein kinase i isoform alpha (CSNK1A1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P48729 CSNK1A1 P48729 Casein kinase i isoform alpha dto:DTO_03100209 A casein kinase I isoform delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48730] casein kinase i isoform delta (CSNK1D) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P48730 CSNK1D HCKID P48730 Casein kinase i isoform delta dto:DTO_03100210 A casein kinase I isoform epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49674] casein kinase i isoform epsilon (CSNK1E) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P49674 CSNK1E P49674 Casein kinase i isoform epsilon dto:DTO_03100211 A casein kinase I isoform gamma-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCP0] casein kinase i isoform gamma-1 (KC1G1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9HCP0 CSNK1G1 Q9HCP0 Casein kinase i isoform gamma-1 dto:DTO_03100212 A casein kinase I isoform gamma-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78368] casein kinase i isoform gamma-2 (KC1G2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P78368 CSNK1G2 CK1G2 P78368 Casein kinase i isoform gamma-2 dto:DTO_03100213 A casein kinase I isoform gamma-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6M4] casein kinase i isoform gamma-3 (CSNK1G3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y6M4 CSNK1G3 Q9Y6M4 Casein kinase i isoform gamma-3 dto:DTO_03100214 A calcium/calmodulin-dependent protein kinase type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14012] calcium/calmodulin-dependent protein kinase type 1 (CAMK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q14012 CAMK1 Q14012 Calcium/calmodulin-dependent protein kinase type 1 dto:DTO_03100215 A calcium/calmodulin-dependent protein kinase type 1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P2M8] https://pharos.nih.gov/idg/targets/Q6P2M8 PNCK Q6P2M8 Calcium/calmodulin-dependent protein kinase type 1b dto:DTO_03100216 A calcium/calmodulin-dependent protein kinase type 1D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IU85] calcium/calmodulin-dependent protein kinase type 1d (CAMK1D) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8IU85 CAMK1D CAMKID Q8IU85 Calcium/calmodulin-dependent protein kinase type 1d dto:DTO_03100217 A calcium/calmodulin-dependent protein kinase type 1G that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96NX5] calcium/calmodulin-dependent protein kinase type 1g (CAMK1G) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q96NX5 CAMK1G CLICK3 VWS1 Q96NX5 Calcium/calmodulin-dependent protein kinase type 1g dto:DTO_03100218 A calcium/calmodulin-dependent protein kinase type II subunit alpha that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UQM7] calcium/calmodulin-dependent protein kinase type ii subunit alpha (CAMK2A) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UQM7 CAMK2A CAMKA KIAA0968 Q9UQM7 Calcium/calmodulin-dependent protein kinase type ii subunit alpha dto:DTO_03100219 A calcium/calmodulin-dependent protein kinase type II subunit beta that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13554] calcium/calmodulin-dependent protein kinase type ii subunit beta (CAMK2B) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13554 CAMK2B CAM2 CAMK2 CAMKB Q13554 Calcium/calmodulin-dependent protein kinase type ii subunit beta dto:DTO_03100220 A calcium/calmodulin-dependent protein kinase type II subunit delta that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13557] calcium/calmodulin-dependent protein kinase type ii subunit delta (KCC2D) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13557 CAMK2D CAMKD Q13557 Calcium/calmodulin-dependent protein kinase type ii subunit delta dto:DTO_03100221 A calcium/calmodulin-dependent protein kinase type II subunit gamma that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13555] calcium/calmodulin-dependent protein kinase type ii subunit gamma (CAMK2G) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13555 CAMK2G CAMK CAMK-II CAMKG Q13555 Calcium/calmodulin-dependent protein kinase type ii subunit gamma dto:DTO_03100222 A calcium/calmodulin-dependent protein kinase type IV that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16566] calcium/calmodulin-dependent protein kinase type iv (KCC4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16566 CAMK4 CAMK CAMK-GR CAMKIV Q16566 Calcium/calmodulin-dependent protein kinase type iv dto:DTO_03100223 A creatine kinase M-type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06732] https://pharos.nih.gov/idg/targets/P06732 CKM CKMM P06732 Creatine kinase m-type dto:DTO_03100224 A cGMP-dependent protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13976] cGMP-dependent protein kinase 1 (KGP1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13976 PRKG1 PRKG1B PRKGR1A PRKGR1B Q13976 Cgmp-dependent protein kinase 1 dto:DTO_03100225 A cGMP-dependent protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13237] cGMP-dependent protein kinase 2 (KGP2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13237 PRKG2 PRKGR2 Q13237 Cgmp-dependent protein kinase 2 dto:DTO_03100226 A guanylate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16774] https://pharos.nih.gov/idg/targets/Q16774 GUK1 GMK Q16774 Guanylate kinase dto:DTO_03100227 A ketohexokinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50053] https://pharos.nih.gov/idg/targets/P50053 KHK P50053 Ketohexokinase dto:DTO_03100228 A mevalonate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03426] https://pharos.nih.gov/idg/targets/Q03426 MVK Q03426 Mevalonate kinase dto:DTO_03100229 A thymidine kinase, cytosolic that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04183] https://pharos.nih.gov/idg/targets/P04183 TK1 P04183 Thymidine kinase, cytosolic dto:DTO_03100230 A thymidine kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00142] https://pharos.nih.gov/idg/targets/O00142 TK2 O00142 Thymidine kinase 2, mitochondrial dto:DTO_03100231 A mast/stem cell growth factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P10721] mast/stem cell growth factor receptor kit (KIT(A829P)) with mutation P829 in KIT(A829P) in a nonphosphorylated state mast/stem cell growth factor receptor kit (KIT(D816H)) with mutation H816 in KIT(D816H) in a nonphosphorylated state mast/stem cell growth factor receptor kit (KIT(D816V)) with mutation V816 in KIT(D816V) in a nonphosphorylated state mast/stem cell growth factor receptor kit (KIT(L576P)) with mutation P576 in KIT(L576P) in a nonphosphorylated state mast/stem cell growth factor receptor kit (KIT(V559D)) with mutation D559 in KIT(V559D) in a nonphosphorylated state mast/stem cell growth factor receptor kit (KIT(V559D,T670I)) with mutation D559 and I670 in KIT(V559D,T670I) in a nonphosphorylated state mast/stem cell growth factor receptor kit (KIT(V559D,V654A)) with mutation D559 and A654 in KIT(V559D,V654A) in a nonphosphorylated state mast/stem cell growth factor receptor kit (KIT) with no mutation in a nonphosphorylated state mast/stem cell growth factor receptor kit (KIT-autoinhibited) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P10721 KIT SCFR P10721 Mast/stem cell growth factor receptor kit dto:DTO_03100232 A calcium/calmodulin-dependent protein kinase kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N5S9] calcium/calmodulin-dependent protein kinase kinase 1 (KKCC1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8N5S9 CAMKK1 CAMKKA Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 dto:DTO_03100233 A calcium/calmodulin-dependent protein kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RR4] calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q96RR4 CAMKK2 CAMKKB KIAA0787 Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 dto:DTO_03100234 A phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/P46020 PHKA1 PHKA P46020 Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform dto:DTO_03100235 A phosphorylase b kinase regulatory subunit alpha, liver isoform that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/P46019 PHKA2 PHKLA PYK P46019 Phosphorylase b kinase regulatory subunit alpha, liver isoform dto:DTO_03100236 A protein kinase C alpha type that is encoded in the genome of human. [PRO:CL, UniProtKB:P17252] https://pharos.nih.gov/idg/targets/P17252 PRKCA PKCA PRKACA P17252 Protein kinase c alpha type dto:DTO_03100237 A protein kinase C beta type that is encoded in the genome of human. [PRO:CNA, UniProtKB:P05771] https://pharos.nih.gov/idg/targets/P05771 PRKCB PKCB PRKCB1 P05771 Protein kinase c beta type dto:DTO_03100238 A serine/threonine-protein kinase D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15139] serine/threonine-protein kinase d1 (KPCD1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15139 PRKD1 PKD PKD1 PRKCM Q15139 Serine/threonine-protein kinase d1 dto:DTO_03100239 A serine/threonine-protein kinase D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZL6] serine/threonine-protein kinase d2 (KPCD2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9BZL6 PRKD2 PKD2 Q9BZL6 Serine/threonine-protein kinase d2 dto:DTO_03100240 A serine/threonine-protein kinase D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94806] serine/threonine-protein kinase d3 (KPCD3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O94806 PRKD3 EPK2 PRKCN O94806 Serine/threonine-protein kinase d3 dto:DTO_03100241 A protein kinase C delta type that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q05655] protein kinase c delta type (KPCD) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q05655 PRKCD Q05655 Protein kinase c delta type dto:DTO_03100242 A protein kinase C epsilon that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q02156] protein kinase c epsilon type (KPCE) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q02156 PRKCE PKCE Q02156 Protein kinase c epsilon type dto:DTO_03100243 A protein kinase C gamma type that is encoded in the genome of human. [PRO:CNA, UniProtKB:P05129] https://pharos.nih.gov/idg/targets/P05129 PRKCG PKCG P05129 Protein kinase c gamma type dto:DTO_03100244 A protein kinase C iota type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41743] protein kinase c iota type (KPCI) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P41743 PRKCI DXS1179E P41743 Protein kinase c iota type dto:DTO_03100245 A protein kinase C eta type that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24723] protein kinase c eta type (KPCL) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P24723 PRKCH PKCL PRKCL P24723 Protein kinase c eta type dto:DTO_03100246 A protein kinase C theta type that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q04759] protein kinase c theta type (KPCT) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q04759 PRKCQ PRKCT Q04759 Protein kinase c theta type dto:DTO_03100247 A protein kinase C zeta type that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05513] https://pharos.nih.gov/idg/targets/Q05513 PRKCZ PKC2 Q05513 Protein kinase c zeta type dto:DTO_03100248 A serine/threonine-protein kinase H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11801] https://pharos.nih.gov/idg/targets/P11801 PSKH1 P11801 Serine/threonine-protein kinase h1 dto:DTO_03100249 A serine/threonine-protein kinase H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QS6] https://pharos.nih.gov/idg/targets/Q96QS6 PSKH2 Q96QS6 Serine/threonine-protein kinase h2 dto:DTO_03100250 A pyruvate kinase isozymes M1/M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14618] https://pharos.nih.gov/idg/targets/P14618 PKM OIP3 PK2 PK3 PKM2 P14618 Pyruvate kinase pkm dto:DTO_03100251 A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15418] ribosomal protein s6 kinase alpha-1 (RSK1(Kin.Dom.1-N-terminal)) with no mutation in a nonphosphorylated state ribosomal protein s6 kinase alpha-1 (RSK1(Kin.Dom.2-C-terminal)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15418 RPS6KA1 MAPKAPK1A RSK1 Q15418 Ribosomal protein s6 kinase alpha-1 dto:DTO_03100252 A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15349] ribosomal protein s6 kinase alpha-2 (RSK3(Kin.Dom.1-N-terminal)) with no mutation in a nonphosphorylated state ribosomal protein s6 kinase alpha-2 (RSK3(Kin.Dom.2-C-terminal)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15349 RPS6KA2 MAPKAPK1C RSK3 Q15349 Ribosomal protein s6 kinase alpha-2 dto:DTO_03100253 A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51812] ribosomal protein s6 kinase alpha-3 (RSK2(Kin.Dom.1-N-terminal)) with no mutation in a nonphosphorylated state ribosomal protein s6 kinase alpha-3 (RSK2(Kin.Dom.2-C-terminal)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P51812 RPS6KA3 ISPK1 MAPKAPK1B RSK2 P51812 Ribosomal protein s6 kinase alpha-3 dto:DTO_03100254 A ribosomal protein S6 kinase alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75676] ribosomal protein s6 kinase alpha-4 (RPS6KA4(Kin.Dom.1-N-terminal)) with no mutation in a nonphosphorylated state ribosomal protein s6 kinase alpha-4 (RPS6KA4(Kin.Dom.2-C-terminal)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O75676 RPS6KA4 MSK2 O75676 Ribosomal protein s6 kinase alpha-4 dto:DTO_03100255 A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75582] ribosomal protein s6 kinase alpha-5 (RPS6KA5(Kin.Dom.1-N-terminal)) with no mutation in a nonphosphorylated state ribosomal protein s6 kinase alpha-5 (RPS6KA5(Kin.Dom.2-C-terminal)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O75582 RPS6KA5 MSK1 O75582 Ribosomal protein s6 kinase alpha-5 dto:DTO_03100256 A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UK32] ribosomal protein s6 kinase alpha-6 (RSK4(Kin.Dom.1-N-terminal)) with no mutation in a nonphosphorylated state ribosomal protein s6 kinase alpha-6 (RSK4(Kin.Dom.2-C-terminal)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UK32 RPS6KA6 RSK4 Q9UK32 Ribosomal protein s6 kinase alpha-6 dto:DTO_03100257 A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P23443] ribosomal protein s6 kinase beta-1 (S6K1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P23443 RPS6KB1 STK14A P23443 Ribosomal protein s6 kinase beta-1 dto:DTO_03100258 A ribosomal protein S6 kinase beta-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UBS0] https://pharos.nih.gov/idg/targets/Q9UBS0 RPS6KB2 STK14B Q9UBS0 Ribosomal protein s6 kinase beta-2 dto:DTO_03100259 A ribosomal protein S6 kinase delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S38] https://pharos.nih.gov/idg/targets/Q96S38 RPS6KC1 RPK118 Q96S38 Ribosomal protein s6 kinase delta-1 dto:DTO_03100260 A kinase suppressor of Ras 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IVT5] https://pharos.nih.gov/idg/targets/Q8IVT5 KSR1 KSR Q8IVT5 Kinase suppressor of ras 1 dto:DTO_03100261 A kinase suppressor of Ras 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6VAB6] https://pharos.nih.gov/idg/targets/Q6VAB6 KSR2 Q6VAB6 Kinase suppressor of ras 2 dto:DTO_03100262 A tyrosine-protein kinase SYK that is encoded in the genome of human. [PRO:CNA, UniProtKB:P43405] tyrosine-protein kinase syk (SYK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P43405 SYK P43405 Tyrosine-protein kinase syk dto:DTO_03100263 A thymidylate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23919] https://pharos.nih.gov/idg/targets/P23919 DTYMK CDC8 TMPK TYMK P23919 Thymidylate kinase dto:DTO_03100264 A serine/threonine-protein kinase LATS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95835] serine/threonine-protein kinase lats1 (LATS1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O95835 LATS1 WARTS O95835 Serine/threonine-protein kinase lats1 dto:DTO_03100265 A serine/threonine-protein kinase LATS2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRM7] serine/threonine-protein kinase lats2 (LATS2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9NRM7 LATS2 KPM Q9NRM7 Serine/threonine-protein kinase lats2 dto:DTO_03100266 A tyrosine-protein kinase Lck that is encoded in the genome of human. tyrosine-protein kinase lck (LCK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P06239 LCK P06239 Tyrosine-protein kinase lck dto:DTO_03100267 A LIM domain kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53667] LIM domain kinase 1 (LIMK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P53667 LIMK1 LIMK P53667 Lim domain kinase 1 dto:DTO_03100268 A LIM domain kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53671] LIM domain kinase 2 (LIMK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P53671 LIMK2 P53671 Lim domain kinase 2 dto:DTO_03100269 A serine/threonine-protein kinase LMTK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZMQ8] https://pharos.nih.gov/idg/targets/Q6ZMQ8 AATK AATYK KIAA0641 LMR1 LMTK1 Q6ZMQ8 Serine/threonine-protein kinase lmtk1 dto:DTO_03100270 A serine/threonine-protein kinase LMTK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWU2] https://pharos.nih.gov/idg/targets/Q8IWU2 LMTK2 AATYK2 BREK KIAA1079 KPI2 LMR2 Q8IWU2 Serine/threonine-protein kinase lmtk2 dto:DTO_03100271 A serine/threonine-protein kinase LMTK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q04] https://pharos.nih.gov/idg/targets/Q96Q04 LMTK3 KIAA1883 TYKLM3 Q96Q04 Serine/threonine-protein kinase lmtk3 dto:DTO_03100272 A leucine-rich repeat serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q38SD2] https://pharos.nih.gov/idg/targets/Q38SD2 LRRK1 KIAA1790 Q38SD2 Leucine-rich repeat serine/threonine-protein kinase 1 dto:DTO_03100273 A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q5S007] leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2(G2019S)) with mutation S2019 in LRRK2(G2019S) in a nonphosphorylated state leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q5S007 LRRK2 PARK8 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 dto:DTO_03100274 A leukocyte tyrosine kinase receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29376] leukocyte tyrosine kinase receptor (LTK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P29376 LTK TYK1 P29376 Leukocyte tyrosine kinase receptor dto:DTO_03100275 A tyrosine-protein kinase Lyn that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07948] tyrosine-protein kinase lyn (LYN) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P07948 LYN JTK8 P07948 Tyrosine-protein kinase lyn dto:DTO_03100276 A mitogen-activated protein kinase kinase kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02779] mitogen-activated protein kinase kinase kinase 10 (MLK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q02779 MAP3K10 MLK2 MST Q02779 Mitogen-activated protein kinase kinase kinase 10 dto:DTO_03100277 A mitogen-activated protein kinase kinase kinase 11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16584] mitogen-activated protein kinase kinase kinase 11 (MLK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16584 MAP3K11 MLK3 PTK1 SPRK Q16584 Mitogen-activated protein kinase kinase kinase 11 dto:DTO_03100278 A mitogen-activated protein kinase kinase kinase 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12852] mitogen-activated protein kinase kinase kinase 12 (M3K12) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q12852 MAP3K12 ZPK Q12852 Mitogen-activated protein kinase kinase kinase 12 dto:DTO_03100279 A mitogen-activated protein kinase kinase kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43283] mitogen-activated protein kinase kinase kinase 13 (M3K13) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O43283 MAP3K13 LZK O43283 Mitogen-activated protein kinase kinase kinase 13 dto:DTO_03100280 A mitogen-activated protein kinase kinase kinase 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99558] mitogen-activated protein kinase kinase kinase 14 (MAP3K14) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q99558 MAP3K14 NIK Q99558 Mitogen-activated protein kinase kinase kinase 14 dto:DTO_03100281 A mitogen-activated protein kinase kinase kinase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZN16] mitogen-activated protein kinase kinase kinase 15 (MAP3K15) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q6ZN16 MAP3K15 ASK3 Q6ZN16 Mitogen-activated protein kinase kinase kinase 15 dto:DTO_03100282 A mitogen-activated protein kinase kinase kinase 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q56UN5] mitogen-activated protein kinase kinase kinase 19 (YSK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q56UN5 MAP3K19 RCK YSK4 Q56UN5 Mitogen-activated protein kinase kinase kinase 19 dto:DTO_03100283 A mitogen-activated protein kinase kinase kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13233] mitogen-activated protein kinase kinase kinase 1 (MAP3K1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13233 MAP3K1 MAPKKK1 MEKK MEKK1 Q13233 Mitogen-activated protein kinase kinase kinase 1 dto:DTO_03100284 A mitogen-activated protein kinase kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2U5] mitogen-activated protein kinase kinase kinase 2 (M3K2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y2U5 MAP3K2 MAPKKK2 MEKK2 Q9Y2U5 Mitogen-activated protein kinase kinase kinase 2 dto:DTO_03100285 A mitogen-activated protein kinase kinase kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99759] mitogen-activated protein kinase kinase kinase 3 (MAP3K3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q99759 MAP3K3 MAPKKK3 MEKK3 Q99759 Mitogen-activated protein kinase kinase kinase 3 dto:DTO_03100286 A mitogen-activated protein kinase kinase kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6R4] mitogen-activated protein kinase kinase kinase 4 (MAP3K4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y6R4 MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 dto:DTO_03100287 A mitogen-activated protein kinase kinase kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99683] mitogen-activated protein kinase kinase kinase 5 (M3K5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q99683 MAP3K5 ASK1 MAPKKK5 MEKK5 Q99683 Mitogen-activated protein kinase kinase kinase 5 dto:DTO_03100288 A mitogen-activated protein kinase kinase kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95382] mitogen-activated protein kinase kinase kinase 6 (M3K6) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O95382 MAP3K6 ASK2 MAPKKK6 MEKK6 O95382 Mitogen-activated protein kinase kinase kinase 6 dto:DTO_03100289 A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human. [Reactome:REACT_7270] mitogen-activated protein kinase kinase kinase 7 (TAK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O43318 MAP3K7 TAK1 O43318 Mitogen-activated protein kinase kinase kinase 7 dto:DTO_03100290 A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/P41279 MAP3K8 COT ESTF P41279 Mitogen-activated protein kinase kinase kinase 8 dto:DTO_03100291 A mitogen-activated protein kinase kinase kinase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P80192] mitogen-activated protein kinase kinase kinase 9 (MLK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P80192 MAP3K9 MLK1 PRKE1 P80192 Mitogen-activated protein kinase kinase kinase 9 dto:DTO_03100292 A mitogen-activated protein kinase kinase kinase that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q5TCX8 MLK4 KIAA1804 Q5TCX8 Mitogen-activated protein kinase kinase kinase mlk4 dto:DTO_03100293 A mitogen-activated protein kinase kinase kinase kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92918] mitogen-activated protein kinase kinase kinase kinase 1 (M4K1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q92918 MAP4K1 HPK1 Q92918 Mitogen-activated protein kinase kinase kinase kinase 1 dto:DTO_03100294 A mitogen-activated protein kinase kinase kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12851] mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q12851 MAP4K2 GCK RAB8IP Q12851 Mitogen-activated protein kinase kinase kinase kinase 2 dto:DTO_03100295 A mitogen-activated protein kinase kinase kinase kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IVH8] mitogen-activated protein kinase kinase kinase kinase 3 (M4K3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8IVH8 MAP4K3 RAB8IPL1 Q8IVH8 Mitogen-activated protein kinase kinase kinase kinase 3 dto:DTO_03100296 A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of human. [PRO:AL, UniProtKB:O95819] mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O95819 MAP4K4 HGK KIAA0687 NIK O95819 Mitogen-activated protein kinase kinase kinase kinase 4 dto:DTO_03100297 A mitogen-activated protein kinase kinase kinase kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4K4] mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y4K4 MAP4K5 Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 dto:DTO_03100298 A serine/threonine-protein kinase MAK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20794] serine/threonine-protein kinase mak (MAK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P20794 MAK P20794 Serine/threonine-protein kinase mak dto:DTO_03100299 A MAP kinase-activated protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49137] MAP kinase-activated protein kinase 2 (MAPKAPK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P49137 MAPKAPK2 P49137 Map kinase-activated protein kinase 2 dto:DTO_03100300 A MAP kinase-activated protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16644] https://pharos.nih.gov/idg/targets/Q16644 MAPKAPK3 Q16644 Map kinase-activated protein kinase 3 dto:DTO_03100301 A MAP kinase-activated protein kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IW41] MAP kinase-activated protein kinase 5 (MAPKAPK5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8IW41 MAPKAPK5 PRAK Q8IW41 Map kinase-activated protein kinase 5 dto:DTO_03100302 A serine/threonine-protein kinase MARK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0L2] serine/threonine-protein kinase mark1 (MARK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9P0L2 MARK1 KIAA1477 MARK Q9P0L2 Serine/threonine-protein kinase mark1 dto:DTO_03100303 A serine/threonine-protein kinase MARK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7KZI7] serine/threonine-protein kinase mark2 (MARK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q7KZI7 MARK2 EMK1 Q7KZI7 Serine/threonine-protein kinase mark2 dto:DTO_03100304 A MAP/microtubule affinity-regulating kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27448] MAP/microtubule affinity-regulating kinase 3 (MARK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P27448 MARK3 CTAK1 EMK2 P27448 Map/microtubule affinity-regulating kinase 3 dto:DTO_03100305 A MAP/microtubule affinity-regulating kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96L34] MAP/microtubule affinity-regulating kinase 4 (MARK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q96L34 MARK4 KIAA1860 MARKL1 Q96L34 Map/microtubule affinity-regulating kinase 4 dto:DTO_03100306 A microtubule-associated serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2H9] microtubule-associated serine/threonine-protein kinase 1 (MAST1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y2H9 MAST1 KIAA0973 SAST Q9Y2H9 Microtubule-associated serine/threonine-protein kinase 1 dto:DTO_03100307 A microtubule-associated serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P0Q8] https://pharos.nih.gov/idg/targets/Q6P0Q8 MAST2 KIAA0807 MAST205 Q6P0Q8 Microtubule-associated serine/threonine-protein kinase 2 dto:DTO_03100308 A microtubule-associated serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60307] https://pharos.nih.gov/idg/targets/O60307 MAST3 KIAA0561 O60307 Microtubule-associated serine/threonine-protein kinase 3 dto:DTO_03100309 A microtubule-associated serine/threonine-protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15021] https://pharos.nih.gov/idg/targets/O15021 MAST4 KIAA0303 O15021 Microtubule-associated serine/threonine-protein kinase 4 dto:DTO_03100310 A megakaryocyte-associated tyrosine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42679] megakaryocyte-associated tyrosine-protein kinase (CTK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P42679 MATK CTK HYL P42679 Megakaryocyte-associated tyrosine-protein kinase dto:DTO_03100311 A maternal embryonic leucine zipper kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14680] maternal embryonic leucine zipper kinase (MELK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q14680 MELK KIAA0175 Q14680 Maternal embryonic leucine zipper kinase dto:DTO_03100312 A tyrosine-protein kinase Mer that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12866] tyrosine-protein kinase mer (MERTK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q12866 MERTK MER Q12866 Tyrosine-protein kinase mer dto:DTO_03100313 A hepatocyte growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08581] hepatocyte growth factor receptor (MET(M1250T)) with mutation T1250 in MET(M1250T) in a nonphosphorylated state hepatocyte growth factor receptor (MET(Y1235D)) with mutation D1235 in MET(Y1235D) in a nonphosphorylated state hepatocyte growth factor receptor (MET) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P08581 MET P08581 Hepatocyte growth factor receptor dto:DTO_03100314 A misshapen-like kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N4C8] misshapen-like kinase 1 (MINK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8N4C8 MINK1 B55 MAP4K6 MINK YSK2 ZC3 Q8N4C8 Misshapen-like kinase 1 dto:DTO_03100315 A mitogen-activated protein kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P28482] mitogen-activated protein kinase 1 (MK01) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P28482 MAPK1 ERK2 PRKM1 PRKM2 P28482 Mitogen-activated protein kinase 1 dto:DTO_03100316 A mitogen-activated protein kinase 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P27361] mitogen-activated protein kinase 3 (MK03) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P27361 MAPK3 ERK1 PRKM3 P27361 Mitogen-activated protein kinase 3 dto:DTO_03100317 A mitogen-activated protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31152] mitogen-activated protein kinase 4 (ERK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P31152 MAPK4 ERK4 PRKM4 P31152 Mitogen-activated protein kinase 4 dto:DTO_03100318 A mitogen-activated protein kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16659] mitogen-activated protein kinase 6 (ERK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16659 MAPK6 ERK3 PRKM6 Q16659 Mitogen-activated protein kinase 6 dto:DTO_03100319 A mitogen-activated protein kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13164] mitogen-activated protein kinase 7 (ERK5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13164 MAPK7 BMK1 ERK5 PRKM7 Q13164 Mitogen-activated protein kinase 7 dto:DTO_03100320 A mitogen-activated protein kinase 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P45983] mitogen-activated protein kinase 8 (JNK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P45983 MAPK8 JNK1 PRKM8 SAPK1 SAPK1C P45983 Mitogen-activated protein kinase 8 dto:DTO_03100321 A mitogen-activated protein kinase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P45984] mitogen-activated protein kinase 9 (MK09) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P45984 MAPK9 JNK2 PRKM9 SAPK1A P45984 Mitogen-activated protein kinase 9 dto:DTO_03100322 A mitogen-activated protein kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53779] mitogen-activated protein kinase 10 (JNK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P53779 MAPK10 JNK3 JNK3A PRKM10 SAPK1B P53779 Mitogen-activated protein kinase 10 dto:DTO_03100323 A mitogen-activated protein kinase 11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15759] mitogen-activated protein kinase 11 (MK11) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15759 MAPK11 PRKM11 SAPK2 SAPK2B Q15759 Mitogen-activated protein kinase 11 dto:DTO_03100324 A mitogen-activated protein kinase 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53778] mitogen-activated protein kinase 12 (MK12) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P53778 MAPK12 ERK6 SAPK3 P53778 Mitogen-activated protein kinase 12 dto:DTO_03100325 A mitogen-activated protein kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15264] mitogen-activated protein kinase 13 (MK13) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O15264 MAPK13 PRKM13 SAPK4 O15264 Mitogen-activated protein kinase 13 dto:DTO_03100326 A mitogen-activated protein kinase 14 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16539] mitogen-activated protein kinase 14 (MK14) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16539 MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A Q16539 Mitogen-activated protein kinase 14 dto:DTO_03100327 A mitogen-activated protein kinase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD08] mitogen-activated protein kinase 15 (ERK8) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8TD08 MAPK15 ERK7 ERK8 Q8TD08 Mitogen-activated protein kinase 15 dto:DTO_03100328 A MAP kinase-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BUB5] MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9BUB5 MKNK1 MNK1 Q9BUB5 Map kinase-interacting serine/threonine-protein kinase 1 dto:DTO_03100329 A MAP kinase-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBH9] MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9HBH9 MKNK2 GPRK7 MNK2 Q9HBH9 Map kinase-interacting serine/threonine-protein kinase 2 dto:DTO_03100330 A mixed lineage kinase domain-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NB16] https://pharos.nih.gov/idg/targets/Q8NB16 MLKL Q8NB16 Mixed lineage kinase domain-like protein dto:DTO_03100331 A mitogen-activated protein kinase kinase kinase MLT that is encoded in the genome of human. mitogen-activated protein kinase kinase kinase mlt (MLTK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9NYL2 ZAK MLTK Q9NYL2 Mitogen-activated protein kinase kinase kinase mlt dto:DTO_03100332 A MAPK/MAK/MRK overlapping kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQ07] https://pharos.nih.gov/idg/targets/Q9UQ07 MOK RAGE RAGE1 Q9UQ07 Mapk/mak/mrk overlapping kinase dto:DTO_03100333 A proto-oncogene serine/threonine-protein kinase mos that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00540] https://pharos.nih.gov/idg/targets/P00540 MOS P00540 Proto-oncogene serine/threonine-protein kinase mos dto:DTO_03100334 A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02750] dual specificity mitogen-activated protein kinase kinase 1 (MP2K1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q02750 MAP2K1 MEK1 PRKMK1 Q02750 Dual specificity mitogen-activated protein kinase kinase 1 dto:DTO_03100335 A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36507] dual specificity mitogen-activated protein kinase kinase 2 (MP2K2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P36507 MAP2K2 MEK2 MKK2 PRKMK2 P36507 Dual specificity mitogen-activated protein kinase kinase 2 dto:DTO_03100336 A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of human. [TLR:AMM, UniProtKB:P46734] dual specificity mitogen-activated protein kinase kinase 3 (MP2K3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P46734 MAP2K3 MEK3 MKK3 PRKMK3 SKK2 P46734 Dual specificity mitogen-activated protein kinase kinase 3 dto:DTO_03100337 A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of human. [TLR:AMM, UniProtKB:P45985] dual specificity mitogen-activated protein kinase kinase 4 (MP2K4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P45985 MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 P45985 Dual specificity mitogen-activated protein kinase kinase 4 dto:DTO_03100338 A dual specificity mitogen-activated protein kinase kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13163] dual specificity mitogen-activated protein kinase kinase 5 (MP2K5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13163 MAP2K5 MEK5 MKK5 PRKMK5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 dto:DTO_03100339 A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of human. [TLR:AMM, UniProtKB:P52564] dual specificity mitogen-activated protein kinase kinase 6 (MP2K6) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P52564 MAP2K6 MEK6 MKK6 PRKMK6 SKK3 P52564 Dual specificity mitogen-activated protein kinase kinase 6 dto:DTO_03100340 A dual specificity mitogen-activated protein kinase kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14733] dual specificity mitogen-activated protein kinase kinase 7 (MP2K7) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O14733 MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 O14733 Dual specificity mitogen-activated protein kinase kinase 7 dto:DTO_03100341 A serine/threonine-protein kinase MRCK alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VT25] serine/threonine-protein kinase mrck alpha (MRCKA) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q5VT25 CDC42BPA KIAA0451 Q5VT25 Serine/threonine-protein kinase mrck alpha dto:DTO_03100342 A serine/threonine-protein kinase MRCK beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5S2] serine/threonine-protein kinase mrck beta (MRCKB) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y5S2 CDC42BPB KIAA1124 Q9Y5S2 Serine/threonine-protein kinase mrck beta dto:DTO_03100343 A serine/threonine-protein kinase MRCK gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6DT37] serine/threonine-protein kinase mrck gamma (DMPK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q6DT37 CDC42BPG DMPK2 Q6DT37 Serine/threonine-protein kinase mrck gamma dto:DTO_03100344 A serine/threonine-protein kinase MST4 that is encoded in the genome of human. [PRO:WCB] serine/threonine-protein kinase mst4 (MST4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9P289 MST4 MASK MST4 STK26 Q9P289 Serine/threonine-protein kinase 26 dto:DTO_03100345 A serine/threonine-protein kinase mTOR that is encoded in the genome of human. [PRO:CL, UniProtKB:P42345] serine/threonine-protein kinase mtor (MTOR) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P42345 MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 P42345 Serine/threonine-protein kinase mtor dto:DTO_03100346 A muscle, skeletal receptor tyrosine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15146] muscle, skeletal receptor tyrosine-protein kinase (MUSK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O15146 MUSK O15146 Muscle, skeletal receptor tyrosine-protein kinase dto:DTO_03100347 A myosin light chain kinase 2, skeletal/cardiac muscle that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H1R3] myosin light chain kinase 2, skeletal/cardiac muscle (MYLK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H1R3 MYLK2 Q9H1R3 Myosin light chain kinase 2, skeletal/cardiac muscle dto:DTO_03100348 A myosin light chain kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q32MK0] myosin light chain kinase 3 (MLCK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q32MK0 MYLK3 MLCK Q32MK0 Myosin light chain kinase 3 dto:DTO_03100349 A myosin light chain kinase family member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86YV6] myosin light chain kinase family member 4 (MYLK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q86YV6 MYLK4 SGK085 Q86YV6 Myosin light chain kinase family member 4 dto:DTO_03100350 A myosin light chain kinase, smooth muscle that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15746] myosin light chain kinase, smooth muscle (MYLK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15746 MYLK MLCK MLCK1 MYLK1 Q15746 Myosin light chain kinase, smooth muscle dto:DTO_03100351 A myosin-IIIa that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NEV4] myosin-IIIa (MYO3A) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8NEV4 MYO3A Q8NEV4 Myosin-iiia dto:DTO_03100352 A myosin-IIIB that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXR4] myosin-IIIb (MYO3B) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8WXR4 MYO3B Q8WXR4 Myosin-iiib dto:DTO_03100353 A serine/threonine-protein kinase Nek10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZWH5] serine/threonine-protein kinase nek10 (NEK10) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q6ZWH5 NEK10 Q6ZWH5 Serine/threonine-protein kinase nek10 dto:DTO_03100354 A serine/threonine-protein kinase Nek11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG66] serine/threonine-protein kinase nek11 (NEK11) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8NG66 NEK11 Q8NG66 Serine/threonine-protein kinase nek11 dto:DTO_03100355 A serine/threonine-protein kinase Nek1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PY6] serine/threonine-protein kinase nek1 (NEK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q96PY6 NEK1 KIAA1901 Q96PY6 Serine/threonine-protein kinase nek1 dto:DTO_03100356 A serine/threonine-protein kinase Nek2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51955] serine/threonine-protein kinase nek2 (NEK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P51955 NEK2 NEK2A NLK1 P51955 Serine/threonine-protein kinase nek2 dto:DTO_03100357 A serine/threonine-protein kinase Nek3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51956] serine/threonine-protein kinase nek3 (NEK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P51956 NEK3 P51956 Serine/threonine-protein kinase nek3 dto:DTO_03100358 A serine/threonine-protein kinase Nek4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51957] serine/threonine-protein kinase nek4 (NEK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P51957 NEK4 STK2 P51957 Serine/threonine-protein kinase nek4 dto:DTO_03100359 A serine/threonine-protein kinase Nek5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P3R8] serine/threonine-protein kinase nek5 (NEK5) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q6P3R8 NEK5 Q6P3R8 Serine/threonine-protein kinase nek5 dto:DTO_03100360 A serine/threonine-protein kinase Nek6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HC98] serine/threonine-protein kinase nek6 (NEK6) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9HC98 NEK6 Q9HC98 Serine/threonine-protein kinase nek6 dto:DTO_03100361 A serine/threonine-protein kinase Nek7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDX7] serine/threonine-protein kinase nek7 (NEK7) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8TDX7 NEK7 Q8TDX7 Serine/threonine-protein kinase nek7 dto:DTO_03100362 A serine/threonine-protein kinase Nek8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86SG6] https://pharos.nih.gov/idg/targets/Q86SG6 NEK8 JCK NEK12A Q86SG6 Serine/threonine-protein kinase nek8 dto:DTO_03100363 A serine/threonine-protein kinase Nek9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD19] serine/threonine-protein kinase nek9 (NEK9) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8TD19 NEK9 KIAA1995 NEK8 NERCC Q8TD19 Serine/threonine-protein kinase nek9 dto:DTO_03100364 An NF-kappa-B essential modulator that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q9Y6K9 IKBKG FIP3 NEMO Q9Y6K9 Nf-kappa-b essential modulator dto:DTO_03100365 A serine/threonine-protein kinase NIM1 that is encoded in the genome of human. serine/threonine-protein kinase nim1 (NIM1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8IY84 NIM1K NIM1 Q8IY84 Serine/threonine-protein kinase nim1 dto:DTO_03100366 A serine/threonine-protein kinase NLK that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBE8] serine/threonine-protein kinase nlk (NLK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UBE8 NLK LAK1 Q9UBE8 Serine/threonine-protein kinase nlk dto:DTO_03100367 A nuclear receptor-binding protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSY0] https://pharos.nih.gov/idg/targets/Q9NSY0 NRBP2 Q9NSY0 Nuclear receptor-binding protein 2 dto:DTO_03100368 A nuclear receptor-binding protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHY1] https://pharos.nih.gov/idg/targets/Q9UHY1 NRBP1 BCON3 NRBP Q9UHY1 Nuclear receptor-binding protein dto:DTO_03100369 A Nik-related protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z2Y5] https://pharos.nih.gov/idg/targets/Q7Z2Y5 NRK Q7Z2Y5 Nik-related protein kinase dto:DTO_03100370 An N-terminal kinase-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KG9] https://pharos.nih.gov/idg/targets/Q96KG9 SCYL1 CVAK90 GKLP NTKL TAPK TEIF TRAP Q96KG9 N-terminal kinase-like protein dto:DTO_03100371 A high affinity nerve growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04629] high affinity nerve growth factor receptor (TRKA) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P04629 NTRK1 MTC TRK TRKA P04629 High affinity nerve growth factor receptor dto:DTO_03100372 A BDNF/NT-3 growth factors receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16620] BDNF/NT-3 growth factors receptor (TRKB) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16620 NTRK2 TRKB Q16620 Bdnf/nt-3 growth factors receptor dto:DTO_03100373 An NT-3 growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16288] NT-3 growth factor receptor (TRKC) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16288 NTRK3 TRKC Q16288 Nt-3 growth factor receptor dto:DTO_03100374 A NUAK family SNF1-like kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60285] NUAK family snf1-like kinase 1 (NUAK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O60285 NUAK1 ARK5 KIAA0537 OMPHK1 O60285 Nuak family snf1-like kinase 1 dto:DTO_03100375 A NUAK family SNF1-like kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H093] NUAK family snf1-like kinase 2 (SNARK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H093 NUAK2 OMPHK2 SNARK Q9H093 Nuak family snf1-like kinase 2 dto:DTO_03100376 An obscurin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VST9] https://pharos.nih.gov/idg/targets/Q5VST9 OBSCN KIAA1556 KIAA1639 Q5VST9 Obscurin dto:DTO_03100377 A serine/threonine-protein kinase OSR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95747] serine/threonine-protein kinase osr1 (OSR1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O95747 OXSR1 KIAA1101 OSR1 O95747 Serine/threonine-protein kinase osr1 dto:DTO_03100378 A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00443] https://pharos.nih.gov/idg/targets/O00443 PIK3C2A O00443 Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha dto:DTO_03100379 A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00750] phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit beta (PIK3C2B) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O00750 PIK3C2B O00750 Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit beta dto:DTO_03100380 A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75747] phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit gamma (PIK3C2G) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O75747 PIK3C2G O75747 Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit gamma dto:DTO_03100381 A phosphatidylinositol 4-kinase type 2-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BTU6] https://pharos.nih.gov/idg/targets/Q9BTU6 PI4K2A Q9BTU6 Phosphatidylinositol 4-kinase type 2-alpha dto:DTO_03100382 A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/P27986 PIK3R1 GRB1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha dto:DTO_03100383 A protein-associating with the carboxyl-terminal domain of ezrin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZE3] https://pharos.nih.gov/idg/targets/Q8IZE3 SCYL3 PACE1 Q8IZE3 Protein-associating with the carboxyl-terminal domain of ezrin dto:DTO_03100384 A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13153] serine/threonine-protein kinase pak 1 (PAK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13153 PAK1 Q13153 Serine/threonine-protein kinase pak 1 dto:DTO_03100385 A serine/threonine-protein kinase PAK 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13177] serine/threonine-protein kinase pak 2 (PAK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13177 PAK2 Q13177 Serine/threonine-protein kinase pak 2 dto:DTO_03100386 A serine/threonine-protein kinase PAK 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75914] serine/threonine-protein kinase pak 3 (PAK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O75914 PAK3 OPHN3 O75914 Serine/threonine-protein kinase pak 3 dto:DTO_03100387 A serine/threonine-protein kinase PAK 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O96013] serine/threonine-protein kinase pak 4 (PAK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O96013 PAK4 KIAA1142 O96013 Serine/threonine-protein kinase pak 4 dto:DTO_03100388 A serine/threonine-protein kinase PAK 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQU5] serine/threonine-protein kinase pak 6 (PAK6) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9NQU5 PAK6 PAK5 Q9NQU5 Serine/threonine-protein kinase pak 6 dto:DTO_03100389 A serine/threonine-protein kinase PAK 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P286] serine/threonine-protein kinase pak 7 (PAK7) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9P286 PAK7 KIAA1264 PAK5 Q9P286 Serine/threonine-protein kinase pak 7 dto:DTO_03100390 A PAB-dependent poly(A)-specific ribonuclease subunit 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q58A45] https://pharos.nih.gov/idg/targets/Q58A45 PAN3 Q58A45 Pab-dependent poly(a)-specific ribonuclease subunit pan3 dto:DTO_03100391 A pantothenate kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE04] https://pharos.nih.gov/idg/targets/Q8TE04 PANK1 PANK Q8TE04 Pantothenate kinase 1 dto:DTO_03100392 A PAS domain-containing serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RG2] https://pharos.nih.gov/idg/targets/Q96RG2 PASK KIAA0135 Q96RG2 Pas domain-containing serine/threonine-protein kinase dto:DTO_03100393 A phosphoenolpyruvate carboxykinase [GTP], mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16822] https://pharos.nih.gov/idg/targets/Q16822 PCK2 PEPCK2 Q16822 Phosphoenolpyruvate carboxykinase [gtp], mitochondrial dto:DTO_03100394 A serine/threonine-protein kinase PDIK1L that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N165] https://pharos.nih.gov/idg/targets/Q8N165 PDIK1L CLIK1L Q8N165 Serine/threonine-protein kinase pdik1l dto:DTO_03100395 A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15118] https://pharos.nih.gov/idg/targets/Q15118 PDK1 PDHK1 Q15118 [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial dto:DTO_03100396 A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15119] https://pharos.nih.gov/idg/targets/Q15119 PDK2 PDHK2 Q15119 [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial dto:DTO_03100397 A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15120] https://pharos.nih.gov/idg/targets/Q15120 PDK3 PDHK3 Q15120 [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial dto:DTO_03100398 A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16654] https://pharos.nih.gov/idg/targets/Q16654 PDK4 PDHK4 Q16654 [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial dto:DTO_03100399 3-phosphoinositide-dependent protein kinase 1 (PDPK1) with no mutation in a nonphosphorylated state A 3-phosphoinositide-dependent protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15530] https://pharos.nih.gov/idg/targets/O15530 PDPK1 PDK1 O15530 3-phosphoinositide-dependent protein kinase 1 dto:DTO_03100400 A 3-phosphoinositide-dependent protein kinase 2 that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q6A1A2 PDPK2P PDPK2 Q6A1A2 Putative 3-phosphoinositide-dependent protein kinase 2 dto:DTO_03100401 A pyridoxal kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00764] https://pharos.nih.gov/idg/targets/O00764 PDXK C21orf124 C21orf97 PKH PNK O00764 Pyridoxal kinase dto:DTO_03100402 A pseudopodium-enriched atypical kinase 1 that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q9H792 PEAK1 KIAA2002 Q9H792 Pseudopodium-enriched atypical kinase 1 dto:DTO_03100403 An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16234] platelet-derived growth factor receptor alpha (PGFRA) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P16234 PDGFRA PDGFR2 RHEPDGFRA P16234 Platelet-derived growth factor receptor alpha dto:DTO_03100404 A beta-type platelet-derived growth factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P09619] platelet-derived growth factor receptor beta (PGFRB) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P09619 PDGFRB PDGFR PDGFR1 P09619 Platelet-derived growth factor receptor beta dto:DTO_03100405 A phosphoglycerate kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00558] https://pharos.nih.gov/idg/targets/P00558 PGK1 PGKA P00558 Phosphoglycerate kinase 1 dto:DTO_03100406 A phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16816] phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16816 PHKG1 PHKG Q16816 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform dto:DTO_03100407 A phosphorylase b kinase gamma catalytic chain, testis/liver isoform that is encoded in the genome of human. phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHKG2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P15735 PHKG2 P15735 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform dto:DTO_03100408 A phosphoinositide 3-kinase regulatory subunit 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99570] https://pharos.nih.gov/idg/targets/Q99570 PIK3R4 Q99570 Phosphoinositide 3-kinase regulatory subunit 4 dto:DTO_03100409 A phosphatidylinositol 5-phosphate 4-kinase type-2 alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48426] https://pharos.nih.gov/idg/targets/P48426 PIP4K2A PIP5K2 PIP5K2A P48426 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha dto:DTO_03100410 A phosphatidylinositol 5-phosphate 4-kinase type-2 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78356] phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP5K2B) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P78356 PIP4K2B PIP5K2B P78356 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta dto:DTO_03100411 A phosphatidylinositol 5-phosphate 4-kinase type-2 gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TBX8] phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PI42C) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8TBX8 PIP4K2C PIP5K2C Q8TBX8 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma dto:DTO_03100412 A phosphatidylinositol 4-kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42356] https://pharos.nih.gov/idg/targets/P42356 PI4KA PIK4 PIK4CA P42356 Phosphatidylinositol 4-kinase alpha dto:DTO_03100413 A phosphatidylinositol 4-kinase beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBF8] phosphatidylinositol 4-kinase beta (PIK4CB) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UBF8 PI4KB PIK4CB Q9UBF8 Phosphatidylinositol 4-kinase beta dto:DTO_03100414 A phosphatidylinositol 4-phosphate 5-kinase type-1 alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99755] phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q99755 PIP5K1A Q99755 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha dto:DTO_03100415 A phosphatidylinositol 4-phosphate 5-kinase type-1 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14986] https://pharos.nih.gov/idg/targets/O14986 PIP5K1B STM7 O14986 Phosphatidylinositol 4-phosphate 5-kinase type-1 beta dto:DTO_03100416 A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma that is encoded in the genome of human. [Reactome:REACT_20457] phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O60331 PIP5K1C KIAA0589 O60331 Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma dto:DTO_03100417 A proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11309] serine/threonine-protein kinase pim-1 (PIM1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P11309 PIM1 P11309 Serine/threonine-protein kinase pim-1 dto:DTO_03100418 A serine/threonine-protein kinase Pim-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P1W9] serine/threonine-protein kinase pim-2 (PIM2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9P1W9 PIM2 Q9P1W9 Serine/threonine-protein kinase pim-2 dto:DTO_03100419 A serine/threonine-protein kinase Pim-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86V86] serine/threonine-protein kinase pim-3 (PIM3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q86V86 PIM3 Q86V86 Serine/threonine-protein kinase pim-3 dto:DTO_03100420 A serine/threonine-protein kinase PINK1, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXM7] https://pharos.nih.gov/idg/targets/Q9BXM7 PINK1 Q9BXM7 Serine/threonine-protein kinase pink1, mitochondrial dto:DTO_03100421 A phosphatidylinositol 3-kinase catalytic subunit type 3 that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q8NEB9 PIK3C3 VPS34 Q8NEB9 Phosphatidylinositol 3-kinase catalytic subunit type 3 dto:DTO_03100422 A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42336] phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(C420R)) with mutation R420 in PIK3CA(C420R) in a nonphosphorylated state phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(E542K)) with mutation K542 in PIK3CA(E542K) in a nonphosphorylated state phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(E545A)) with mutation A545 in PIK3CA(E545A) in a nonphosphorylated state phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(E545K)) with mutation K545 in PIK3CA(E545K) in a nonphosphorylated state phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(H1047L)) with mutation L1047 in PIK3CA(H1047L) in a nonphosphorylated state phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(H1047Y)) with mutation Y1047 in PIK3CA(H1047Y) in a nonphosphorylated state phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(I800L)) with mutation L800 in PIK3CA(I800L) in a nonphosphorylated state phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(M1043I)) with mutation I1043 in PIK3CA(M1043I) in a nonphosphorylated state phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(Q546K)) with mutation K546 in PIK3CA(Q546K) in a nonphosphorylated state phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P42336 PIK3CA P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform dto:DTO_03100423 A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42338] phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P42338 PIK3CB PIK3C1 P42338 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform dto:DTO_03100424 A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00329] phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O00329 PIK3CD O00329 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform dto:DTO_03100425 A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48736] phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P48736 PIK3CG P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform dto:DTO_03100426 A protein kinase-like protein SgK493 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q504Y2] https://pharos.nih.gov/idg/targets/Q504Y2 PKDCC SGK493 VLK Q504Y2 Extracellular tyrosine-protein kinase PKDCC dto:DTO_03100427 A serine/threonine-protein kinase N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16512] serine/threonine-protein kinase n1 (PKN1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16512 PKN1 PAK1 PKN PRK1 PRKCL1 Q16512 Serine/threonine-protein kinase n1 dto:DTO_03100428 A serine/threonine-protein kinase N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16513] serine/threonine-protein kinase n2 (PKN2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q16513 PKN2 PRK2 PRKCL2 Q16513 Serine/threonine-protein kinase n2 dto:DTO_03100429 A serine/threonine-protein kinase N3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P5Z2] https://pharos.nih.gov/idg/targets/Q6P5Z2 PKN3 PKNBETA Q6P5Z2 Serine/threonine-protein kinase n3 dto:DTO_03100430 A serine/threonine-protein kinase PLK1 that is encoded in the genome of human. [PMID:16129782, PMID:16580887, PMID:16760428, PMID:17376779, PMID:20624902, PMID:20823832, PRO:KER] serine/threonine-protein kinase plk1 (PLK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P53350 PLK1 PLK P53350 Serine/threonine-protein kinase plk1 dto:DTO_03100431 A serine/threonine-protein kinase PLK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYY3] serine/threonine-protein kinase plk2 (PLK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9NYY3 PLK2 SNK Q9NYY3 Serine/threonine-protein kinase plk2 dto:DTO_03100432 A serine/threonine-protein kinase PLK3 that is encoded in the genome of human. [PMID:15190214, PRO:KER] serine/threonine-protein kinase plk3 (PLK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H4B4 PLK3 CNK FNK PRK Q9H4B4 Serine/threonine-protein kinase plk3 dto:DTO_03100433 A serine/threonine-protein kinase PLK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00444] serine/threonine-protein kinase plk4 (PLK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O00444 PLK4 SAK STK18 O00444 Serine/threonine-protein kinase plk4 dto:DTO_03100434 An inactive serine/threonine-protein kinase PLK5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q496M5] https://pharos.nih.gov/idg/targets/Q496M5 PLK5 PLK5P Q496M5 Inactive serine/threonine-protein kinase plk5 dto:DTO_03100435 A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99640] membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q99640 PKMYT1 MYT1 Q99640 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase dto:DTO_03100436 A DNA-dependent protein kinase catalytic subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78527] https://pharos.nih.gov/idg/targets/P78527 PRKDC HYRC HYRC1 P78527 Dna-dependent protein kinase catalytic subunit dto:DTO_03100437 An interferon-inducible double-stranded RNA-dependent protein kinase activator A that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75569] https://pharos.nih.gov/idg/targets/O75569 PRKRA PACT RAX O75569 Interferon-inducible double-stranded rna-dependent protein kinase activator a dto:DTO_03100438 A serine/threonine-protein kinase PRKX that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51817] camp-dependent protein kinase catalytic subunit prkx (PRKX) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P51817 PRKX PKX1 P51817 Camp-dependent protein kinase catalytic subunit prkx dto:DTO_03100439 A serine/threonine-protein kinase PRKY that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43930] https://pharos.nih.gov/idg/targets/O43930 PRKY O43930 Putative serine/threonine-protein kinase prky dto:DTO_03100440 A serine/threonine-protein kinase PRP4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13523] serine/threonine-protein kinase prp4 homolog (PRP4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13523 PRPF4B KIAA0536 PRP4 PRP4H PRP4K Q13523 Serine/threonine-protein kinase prp4 homolog dto:DTO_03100441 A TP53-regulating kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S44] https://pharos.nih.gov/idg/targets/Q96S44 TP53RK C20orf64 PRPK Q96S44 Tp53-regulating kinase dto:DTO_03100442 A protein-tyrosine kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13882] protein-tyrosine kinase 6 (PTK6) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13882 PTK6 BRK Q13882 Protein-tyrosine kinase 6 dto:DTO_03100443 An inactive tyrosine-protein kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13308] https://pharos.nih.gov/idg/targets/Q13308 PTK7 CCK4 Q13308 Inactive tyrosine-protein kinase 7 dto:DTO_03100444 A PX domain-containing protein kinase-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z7A4] https://pharos.nih.gov/idg/targets/Q7Z7A4 PXK Q7Z7A4 Px domain-containing protein kinase-like protein dto:DTO_03100445 A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human. [PMID:20703093, PRO:KER] RAF proto-oncogene serine/threonine-protein kinase (RAF1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P04049 RAF1 RAF P04049 Raf proto-oncogene serine/threonine-protein kinase dto:DTO_03100446 A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07949] proto-oncogene tyrosine-protein kinase receptor ret (RET(M918T)) with mutation T918 in RET(M918T) in a nonphosphorylated state proto-oncogene tyrosine-protein kinase receptor ret (RET(V804L)) with mutation L804 in RET(V804L) in a nonphosphorylated state proto-oncogene tyrosine-protein kinase receptor ret (RET(V804M)) with mutation M804 in RET(V804M) in a nonphosphorylated state proto-oncogene tyrosine-protein kinase receptor ret (RET) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P07949 RET CDHF12 CDHR16 PTC RET51 P07949 Proto-oncogene tyrosine-protein kinase receptor ret dto:DTO_03100448 A serine/threonine-protein kinase RIO2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BVS4] serine/threonine-protein kinase rio2 (RIOK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9BVS4 RIOK2 Q9BVS4 Serine/threonine-protein kinase rio2 dto:DTO_03100450 A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. receptor-interacting serine/threonine-protein kinase 1 (RIPK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13546 RIPK1 RIP RIP1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 dto:DTO_03100451 A receptor-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43353] receptor-interacting serine/threonine-protein kinase 2 (RIPK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O43353 RIPK2 CARDIAK RICK RIP2 O43353 Receptor-interacting serine/threonine-protein kinase 2 dto:DTO_03100452 A receptor-interacting serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:CNA, Reactome:REACT_22021] https://pharos.nih.gov/idg/targets/Q9Y572 RIPK3 RIP3 Q9Y572 Receptor-interacting serine/threonine-protein kinase 3 dto:DTO_03100453 A receptor-interacting serine/threonine-protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57078] receptor-interacting serine/threonine-protein kinase 4 (RIPK4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P57078 RIPK4 ANKRD3 DIK P57078 Receptor-interacting serine/threonine-protein kinase 4 dto:DTO_03100454 A rhodopsin kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15835] rhodopsin kinase (GRK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15835 GRK1 RHOK Q15835 Rhodopsin kinase dto:DTO_03100455 A 2-5A-dependent ribonuclease that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05823] https://pharos.nih.gov/idg/targets/Q05823 RNASEL RNS4 Q05823 2-5a-dependent ribonuclease dto:DTO_03100456 A rho-associated protein kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13464] rho-associated protein kinase 1 (ROCK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13464 ROCK1 Q13464 Rho-associated protein kinase 1 dto:DTO_03100457 A rho-associated protein kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O75116] rho-associated protein kinase 2 (ROCK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O75116 ROCK2 KIAA0619 O75116 Rho-associated protein kinase 2 dto:DTO_03100458 A macrophage-stimulating protein receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q04912] macrophage-stimulating protein receptor (MST1R) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q04912 MST1R PTK8 RON Q04912 Macrophage-stimulating protein receptor dto:DTO_03100459 A tyrosine-protein kinase transmembrane receptor ROR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q01973] https://pharos.nih.gov/idg/targets/Q01973 ROR1 NTRKR1 Q01973 Tyrosine-protein kinase transmembrane receptor ror1 dto:DTO_03100460 A tyrosine-protein kinase transmembrane receptor ROR2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q01974] https://pharos.nih.gov/idg/targets/Q01974 ROR2 NTRKR2 Q01974 Tyrosine-protein kinase transmembrane receptor ror2 dto:DTO_03100461 A proto-oncogene tyrosine-protein kinase ROS that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08922] proto-oncogene tyrosine-protein kinase ros (ROS1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P08922 ROS1 MCF3 ROS P08922 Proto-oncogene tyrosine-protein kinase ros dto:DTO_03100462 A ribosomal protein S6 kinase-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6S9] https://pharos.nih.gov/idg/targets/Q9Y6S9 RPS6KL1 Q9Y6S9 Ribosomal protein s6 kinase-like 1 dto:DTO_03100463 A tyrosine-protein kinase RYK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34925] https://pharos.nih.gov/idg/targets/P34925 RYK JTK5A P34925 Tyrosine-protein kinase ryk dto:DTO_03100464 A serine/threonine-protein kinase SBK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q52WX2] serine/threonine-protein kinase sbk1 (SBK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q52WX2 SBK1 Q52WX2 Serine/threonine-protein kinase sbk1 dto:DTO_03100465 A serine/threonine-protein kinase SBK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C263] https://pharos.nih.gov/idg/targets/P0C263 SBK2 SGK069 P0C263 Serine/threonine-protein kinase sbk2 dto:DTO_03100466 A uncharacterized serine/threonine-protein kinase SgK110 that is encoded in the genome of human. uncharacterized serine/threonine-protein kinase sbk3 (SgK110) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P0C264 SBK3 SGK110 P0C264 Uncharacterized serine/threonine-protein kinase sbk3 dto:DTO_03100467 A SCY1-like protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P3W7] https://pharos.nih.gov/idg/targets/Q6P3W7 SCYL2 CVAK104 KIAA1360 Q6P3W7 Scy1-like protein 2 dto:DTO_03100468 A protein kinase-like protein SgK196 that is encoded in the genome of human. [OMA:HUMAN26853, PRO:DNx] https://pharos.nih.gov/idg/targets/Q9H5K3 POMK SGK196 Q9H5K3 Protein o-mannose kinase dto:DTO_03100469 A tyrosine-protein kinase SgK223 that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q86YV5 SGK223 Q86YV5 Tyrosine-protein kinase sgk223 dto:DTO_03100470 An uncharacterized serine/threonine-protein kinase SgK494 that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/Q96LW2 SGK494 Q96LW2 Uncharacterized serine/threonine-protein kinase sgk494 dto:DTO_03100471 A serine/threonine-protein kinase Sgk1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00141] serine/threonine-protein kinase sgk1 (SGK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O00141 SGK1 SGK O00141 Serine/threonine-protein kinase sgk1 dto:DTO_03100472 A serine/threonine-protein kinase Sgk2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBY8] serine/threonine-protein kinase sgk2 (SGK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9HBY8 SGK2 Q9HBY8 Serine/threonine-protein kinase sgk2 dto:DTO_03100473 A serine/threonine-protein kinase Sgk3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96BR1] serine/threonine-protein kinase sgk3 (SGK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q96BR1 SGK3 CISK SGKL Q96BR1 Serine/threonine-protein kinase sgk3 dto:DTO_03100474 A protein kinase-like protein SgK071 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NE28] https://pharos.nih.gov/idg/targets/Q8NE28 STKLD1 C9orf96 SGK071 Q8NE28 Serine/threonine kinase-like domain-containing protein stkld1 dto:DTO_03100475 A serine/threonine-protein kinase SIK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57059] serine/threonine-protein kinase sik1 (SIK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P57059 SIK1 SIK SNF1LK P57059 Serine/threonine-protein kinase sik1 dto:DTO_03100476 A serine/threonine-protein kinase SIK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H0K1] serine/threonine-protein kinase sik2 (SIK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H0K1 SIK2 KIAA0781 QIK SNF1LK2 Q9H0K1 Serine/threonine-protein kinase sik2 dto:DTO_03100477 A serine/threonine-protein kinase QSK that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2K2] serine/threonine-protein kinase sik3 (SIK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y2K2 SIK3 KIAA0999 QSK Q9Y2K2 Serine/threonine-protein kinase sik3 dto:DTO_03100478 A STE20-like serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2G2] STE20-like serine/threonine-protein kinase (SLK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H2G2 SLK KIAA0204 STK2 Q9H2G2 Ste20-like serine/threonine-protein kinase dto:DTO_03100479 A serine/threonine-protein kinase SMG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q15] https://pharos.nih.gov/idg/targets/Q96Q15 SMG1 ATX KIAA0421 LIP Q96Q15 Serine/threonine-protein kinase smg1 dto:DTO_03100480 An SNF-related serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRH2] SNF-related serine/threonine-protein kinase (SNRK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9NRH2 SNRK KIAA0096 SNFRK Q9NRH2 Snf-related serine/threonine-protein kinase dto:DTO_03100481 A striated muscle preferentially expressed protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15772] https://pharos.nih.gov/idg/targets/Q15772 SPEG APEG1 KIAA1297 Q15772 Striated muscle preferentially expressed protein kinase dto:DTO_03100482 A sphingosine kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYA1] https://pharos.nih.gov/idg/targets/Q9NYA1 SPHK1 SPHK SPK Q9NYA1 Sphingosine kinase 1 dto:DTO_03100483 A sphingosine kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRA0] https://pharos.nih.gov/idg/targets/Q9NRA0 SPHK2 Q9NRA0 Sphingosine kinase 2 dto:DTO_03100484 A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of human. [PRO:CNA, UniProtKB:P12931] proto-oncogene tyrosine-protein kinase src (SRC) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P12931 SRC SRC1 P12931 Proto-oncogene tyrosine-protein kinase src dto:DTO_03100485 A tyrosine-protein kinase Srms that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H3Y6] tyrosine-protein kinase srms (SRMS) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H3Y6 SRMS C20orf148 Q9H3Y6 Tyrosine-protein kinase srms dto:DTO_03100486 An SRSF protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96SB4] SRSF protein kinase 1 (SRPK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q96SB4 SRPK1 Q96SB4 Srsf protein kinase 1 dto:DTO_03100487 An SRSF protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78362] SRSF protein kinase 2 (SRPK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P78362 SRPK2 P78362 Srsf protein kinase 2 dto:DTO_03100488 An SRSF protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UPE1] SRSF protein kinase 3 (SRPK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UPE1 SRPK3 MSSK1 STK23 Q9UPE1 Srsf protein kinase 3 dto:DTO_03100489 A serine/threonine-protein kinase 17A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UEE5] serine/threonine-protein kinase 17a (DRAK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UEE5 STK17A DRAK1 Q9UEE5 Serine/threonine-protein kinase 17a dto:DTO_03100490 A serine/threonine-protein kinase 17B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94768] serine/threonine-protein kinase 17b (DRAK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O94768 STK17B DRAK2 O94768 Serine/threonine-protein kinase 17b dto:DTO_03100491 A serine/threonine-protein kinase 32A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WU08] serine/threonine-protein kinase 32a (YANK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8WU08 STK32A YANK1 Q8WU08 Serine/threonine-protein kinase 32a dto:DTO_03100492 A serine/threonine-protein kinase 32B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY57] serine/threonine-protein kinase 32b (YANK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9NY57 STK32B YANK2 Q9NY57 Serine/threonine-protein kinase 32b dto:DTO_03100493 A serine/threonine-protein kinase 32C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86UX6] serine/threonine-protein kinase 32c (YANK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q86UX6 STK32C YANK3 Q86UX6 Serine/threonine-protein kinase 32c dto:DTO_03100494 A serine/threonine-protein kinase 38-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2H1] serine/threonine-protein kinase 38-like (NDR2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y2H1 STK38L KIAA0965 NDR2 Q9Y2H1 Serine/threonine-protein kinase 38-like dto:DTO_03100495 A serine/threonine-protein kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94804] serine/threonine-protein kinase 10 (LOK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O94804 STK10 LOK O94804 Serine/threonine-protein kinase 10 dto:DTO_03100496 A serine/threonine-protein kinase STK11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15831] serine/threonine-protein kinase stk11 (LKB1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15831 STK11 LKB1 PJS Q15831 Serine/threonine-protein kinase stk11 dto:DTO_03100497 A serine/threonine-protein kinase 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75716] serine/threonine-protein kinase 16 (STK16) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O75716 STK16 MPSK1 PKL12 TSF1 O75716 Serine/threonine-protein kinase 16 dto:DTO_03100498 A serine/threonine-protein kinase 24 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y6E0] serine/threonine-protein kinase 24 (MST3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9Y6E0 STK24 MST3 STK3 Q9Y6E0 Serine/threonine-protein kinase 24 dto:DTO_03100499 A serine/threonine-protein kinase 25 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00506] serine/threonine-protein kinase 25 (YSK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O00506 STK25 SOK1 YSK1 O00506 Serine/threonine-protein kinase 25 dto:DTO_03100500 A serine/threonine-protein kinase 31 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXU1] https://pharos.nih.gov/idg/targets/Q9BXU1 STK31 SGK396 Q9BXU1 Serine/threonine-protein kinase 31 dto:DTO_03100501 A serine/threonine-protein kinase 33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BYT3] serine/threonine-protein kinase 33 (STK33) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9BYT3 STK33 Q9BYT3 Serine/threonine-protein kinase 33 dto:DTO_03100502 A serine/threonine-protein kinase 35 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDR2] serine/threonine-protein kinase 35 (STK35) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8TDR2 STK35 CLIK1 PDIK1 STK35L1 Q8TDR2 Serine/threonine-protein kinase 35 dto:DTO_03100503 A serine/threonine-protein kinase 36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRP7] serine/threonine-protein kinase 36 (STK36) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9NRP7 STK36 KIAA1278 Q9NRP7 Serine/threonine-protein kinase 36 dto:DTO_03100504 A serine/threonine-protein kinase 38 that is encoded in the genome of human. [PRO:KER] serine/threonine-protein kinase 38 (NDR1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15208 STK38 NDR1 Q15208 Serine/threonine-protein kinase 38 dto:DTO_03100505 A STE20/SPS1-related proline-alanine-rich protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UEW8] STE20/sps1-related proline-alanine-rich protein kinase (STK39) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UEW8 STK39 SPAK Q9UEW8 Ste20/sps1-related proline-alanine-rich protein kinase dto:DTO_03100506 A serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13188] serine/threonine-protein kinase 3 (MST2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13188 STK3 KRS1 MST2 Q13188 Serine/threonine-protein kinase 3 dto:DTO_03100507 A serine/threonine-protein kinase 40 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N2I9] https://pharos.nih.gov/idg/targets/Q8N2I9 STK40 SGK495 SHIK Q8N2I9 Serine/threonine-protein kinase 40 dto:DTO_03100508 A serine/threonine-protein kinase 4 that is encoded in the genome of human. [PMID:20171103, PRO:KER] serine/threonine-protein kinase 4 (MST1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13043 STK4 KRS2 MST1 Q13043 Serine/threonine-protein kinase 4 dto:DTO_03100509 A STE20-related kinase adapter protein alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTN6] https://pharos.nih.gov/idg/targets/Q7RTN6 STRADA LYK5 STRAD Q7RTN6 Ste20-related kinase adapter protein alpha dto:DTO_03100510 A STE20-related kinase adapter protein beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C0K7] https://pharos.nih.gov/idg/targets/Q9C0K7 STRADB ALS2CR2 ILPIP Q9C0K7 Ste20-related kinase adapter protein beta dto:DTO_03100511 A tyrosine-protein kinase STYK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6J9G0] https://pharos.nih.gov/idg/targets/Q6J9G0 STYK1 NOK Q6J9G0 Tyrosine-protein kinase styk1 dto:DTO_03100512 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA] https://pharos.nih.gov/idg/targets/Q15750 TAB1 MAP3K7IP1 Q15750 Tgf-beta-activated kinase 1 and map3k7-binding protein 1 dto:DTO_03100513 A transcription initiation factor TFIID subunit 1 that is encoded in the genome of human. https://pharos.nih.gov/idg/targets/P21675 TAF1 BA2R CCG1 CCGS TAF2A P21675 Transcription initiation factor tfiid subunit 1 dto:DTO_03100514 A serine/threonine-protein kinase TAO1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7L7X3] serine/threonine-protein kinase tao1 (TAOK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q7L7X3 TAOK1 KIAA1361 MAP3K16 MARKK Q7L7X3 Serine/threonine-protein kinase tao1 dto:DTO_03100515 A serine/threonine-protein kinase TAO2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UL54] serine/threonine-protein kinase tao2 (TAOK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UL54 TAOK2 KIAA0881 MAP3K17 PSK PSK1 Q9UL54 Serine/threonine-protein kinase tao2 dto:DTO_03100516 A serine/threonine-protein kinase TAO3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2K8] serine/threonine-protein kinase tao3 (TAOK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H2K8 TAOK3 DPK JIK KDS MAP3K18 Q9H2K8 Serine/threonine-protein kinase tao3 dto:DTO_03100518 A serine/threonine-protein kinase TBK1 that is encoded in the genome of human. [PMID:17327220, PRO:CNA, Reactome:REACT_21591] serine/threonine-protein kinase tbk1 (TBK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UHD2 TBK1 NAK Q9UHD2 Serine/threonine-protein kinase tbk1 dto:DTO_03100519 A tyrosine-protein kinase Tec that is encoded in the genome of human. [PRO:WCB, UniProtKB:P42680] tyrosine-protein kinase tec (TEC) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P42680 TEC PSCTK4 P42680 Tyrosine-protein kinase tec dto:DTO_03100520 A dual specificity testis-specific protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15569] dual specificity testis-specific protein kinase 1 (TESK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q15569 TESK1 Q15569 Dual specificity testis-specific protein kinase 1 dto:DTO_03100521 A dual specificity testis-specific protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S53] https://pharos.nih.gov/idg/targets/Q96S53 TESK2 Q96S53 Dual specificity testis-specific protein kinase 2 dto:DTO_03100522 A testis-expressed protein 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWB6] https://pharos.nih.gov/idg/targets/Q8IWB6 TEX14 SGK307 Q8IWB6 Inactive serine/threonine-protein kinase tex14 dto:DTO_03100523 A TGF-beta receptor type-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36897] TGF-beta receptor type-1 (TGFBR1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P36897 TGFBR1 ALK5 SKR4 P36897 Tgf-beta receptor type-1 dto:DTO_03100524 A TGF-beta receptor type-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P37173] TGF-beta receptor type-2 (TGFBR2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P37173 TGFBR2 P37173 Tgf-beta receptor type-2 dto:DTO_03100525 A tyrosine-protein kinase receptor Tie-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35590] tyrosine-protein kinase receptor tie-1 (TIE1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P35590 TIE1 TIE P35590 Tyrosine-protein kinase receptor tie-1 dto:DTO_03100526 An angiopoietin-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q02763] angiopoietin-1 receptor (TIE2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q02763 TEK TIE2 VMCM VMCM1 Q02763 Angiopoietin-1 receptor dto:DTO_03100527 A titin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ42] https://pharos.nih.gov/idg/targets/Q8WZ42 TTN Q8WZ42 Titin dto:DTO_03100528 A serine/threonine-protein kinase tousled-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKI8] serine/threonine-protein kinase tousled-like 1 (TLK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UKI8 TLK1 KIAA0137 Q9UKI8 Serine/threonine-protein kinase tousled-like 1 dto:DTO_03100529 A serine/threonine-protein kinase tousled-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86UE8] serine/threonine-protein kinase tousled-like 2 (TLK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q86UE8 TLK2 Q86UE8 Serine/threonine-protein kinase tousled-like 2 dto:DTO_03100530 A serine/threonine-protein kinase TNNI3K that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q59H18] serine/threonine-protein kinase tnni3k (TNNI3K) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q59H18 TNNI3K CARK Q59H18 Serine/threonine-protein kinase tnni3k dto:DTO_03100531 A TRAF2 and NCK-interacting protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKE5] TRAF2 and nck-interacting protein kinase (TNIK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9UKE5 TNIK KIAA0551 Q9UKE5 Traf2 and nck-interacting protein kinase dto:DTO_03100532 A non-receptor tyrosine-protein kinase TNK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13470] non-receptor tyrosine-protein kinase tnk1 (TNK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q13470 TNK1 Q13470 Non-receptor tyrosine-protein kinase tnk1 dto:DTO_03100533 A lymphokine-activated killer T-cell-originated protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KB5] https://pharos.nih.gov/idg/targets/Q96KB5 PBK TOPK Q96KB5 Lymphokine-activated killer t-cell-originated protein kinase dto:DTO_03100534 A thiamin pyrophosphokinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H3S4] https://pharos.nih.gov/idg/targets/Q9H3S4 TPK1 Q9H3S4 Thiamin pyrophosphokinase 1 dto:DTO_03100535 A tribbles homolog 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RU8] https://pharos.nih.gov/idg/targets/Q96RU8 TRIB1 C8FW GIG2 TRB1 Q96RU8 Tribbles homolog 1 dto:DTO_03100536 A tribbles homolog 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92519] https://pharos.nih.gov/idg/targets/Q92519 TRIB2 TRB2 Q92519 Tribbles homolog 2 dto:DTO_03100537 A tribbles homolog 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RU7] https://pharos.nih.gov/idg/targets/Q96RU7 TRIB3 C20orf97 NIPK SKIP3 TRB3 Q96RU7 Tribbles homolog 3 dto:DTO_03100538 A triple functional domain protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75962] https://pharos.nih.gov/idg/targets/O75962 TRIO O75962 Triple functional domain protein dto:DTO_03100539 A transient receptor potential cation channel subfamily M member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BX84] transient receptor potential cation channel subfamily m member 6 (TRPM6) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9BX84 TRPM6 CHAK2 Q9BX84 Transient receptor potential cation channel subfamily m member 6 dto:DTO_03100540 A testis-specific serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXA7] testis-specific serine/threonine-protein kinase 1 (TSSK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9BXA7 TSSK1B SPOGA1 SPOGA4 STK22A STK22D TSSK1 Q9BXA7 Testis-specific serine/threonine-protein kinase 1 dto:DTO_03100541 A testis-specific serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PF2] https://pharos.nih.gov/idg/targets/Q96PF2 TSSK2 DGSG SPOGA2 STK22B Q96PF2 Testis-specific serine/threonine-protein kinase 2 dto:DTO_03100542 A testis-specific serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PN8] https://pharos.nih.gov/idg/targets/Q96PN8 TSSK3 SPOGA3 STK22C Q96PN8 Testis-specific serine/threonine-protein kinase 3 dto:DTO_03100543 A testis-specific serine/threonine-protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6SA08] https://pharos.nih.gov/idg/targets/Q6SA08 TSSK4 C14orf20 STK22E TSSK5 Q6SA08 Testis-specific serine/threonine-protein kinase 4 dto:DTO_03100544 A testis-specific serine/threonine-protein kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXA6] https://pharos.nih.gov/idg/targets/Q9BXA6 TSSK6 SSTK Q9BXA6 Testis-specific serine/threonine-protein kinase 6 dto:DTO_03100545 A tau-tubulin kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TCY1] https://pharos.nih.gov/idg/targets/Q5TCY1 TTBK1 BDTK KIAA1855 Q5TCY1 Tau-tubulin kinase 1 dto:DTO_03100546 A tau-tubulin kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IQ55] https://pharos.nih.gov/idg/targets/Q6IQ55 TTBK2 KIAA0847 Q6IQ55 Tau-tubulin kinase 2 dto:DTO_03100547 A dual specificity protein kinase TTK that is encoded in the genome of human. [PMID:20823832, PRO:KER] dual specificity protein kinase ttk (TTK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P33981 TTK MPS1 MPS1L1 P33981 Dual specificity protein kinase ttk dto:DTO_03100548 A tyrosine-protein kinase TXK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42681] tyrosine-protein kinase txk (TXK) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P42681 TXK PTK4 RLK P42681 Tyrosine-protein kinase txk dto:DTO_03100549 A non-receptor tyrosine-protein kinase TYK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29597] non-receptor tyrosine-protein kinase tyk2 (TYK2(JH1domain-catalytic)) with no mutation in a nonphosphorylated state non-receptor tyrosine-protein kinase tyk2 (TYK2(JH2domain-pseudokinase)) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P29597 TYK2 P29597 Non-receptor tyrosine-protein kinase tyk2 dto:DTO_03100550 A tyrosine-protein kinase receptor TYRO3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06418] tyrosine-protein kinase receptor tyro3 (TYRO3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q06418 TYRO3 BYK DTK RSE SKY TIF Q06418 Tyrosine-protein kinase receptor tyro3 dto:DTO_03100551 A uridine-cytidine kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HA47] https://pharos.nih.gov/idg/targets/Q9HA47 UCK1 URK1 Q9HA47 Uridine-cytidine kinase 1 dto:DTO_03100552 A uridine-cytidine kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZX2] https://pharos.nih.gov/idg/targets/Q9BZX2 UCK2 UMPK Q9BZX2 Uridine-cytidine kinase 2 dto:DTO_03100553 A tyrosine-protein kinase receptor UFO that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30530] tyrosine-protein kinase receptor ufo (AXL) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P30530 AXL UFO P30530 Tyrosine-protein kinase receptor ufo dto:DTO_03100554 A serine/threonine-protein kinase Kist that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TAS1] https://pharos.nih.gov/idg/targets/Q8TAS1 UHMK1 KIS KIST Q8TAS1 Serine/threonine-protein kinase kist dto:DTO_03100555 A serine/threonine-protein kinase ULK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75385] serine/threonine-protein kinase ulk1 (ULK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/O75385 ULK1 KIAA0722 O75385 Serine/threonine-protein kinase ulk1 dto:DTO_03100556 A serine/threonine-protein kinase ULK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IYT8] serine/threonine-protein kinase ulk2 (ULK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q8IYT8 ULK2 KIAA0623 Q8IYT8 Serine/threonine-protein kinase ulk2 dto:DTO_03100557 A serine/threonine-protein kinase ULK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PHR2] serine/threonine-protein kinase ulk3 (ULK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q6PHR2 ULK3 Q6PHR2 Serine/threonine-protein kinase ulk3 dto:DTO_03100558 A serine/threonine-protein kinase ULK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96C45] https://pharos.nih.gov/idg/targets/Q96C45 ULK4 Q96C45 Serine/threonine-protein kinase ulk4 dto:DTO_03100559 A vascular endothelial growth factor receptor 1 that is encoded in the genome of human. [PRO:CNA] vascular endothelial growth factor receptor 1 (VGFR1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P17948 FLT1 FLT FRT VEGFR1 P17948 Vascular endothelial growth factor receptor 1 dto:DTO_03100560 A vascular endothelial growth factor receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35968] vascular endothelial growth factor receptor 2 (VGFR2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P35968 KDR FLK1 VEGFR2 P35968 Vascular endothelial growth factor receptor 2 dto:DTO_03100561 A vascular endothelial growth factor receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35916] vascular endothelial growth factor receptor 3 (FLT4) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P35916 FLT4 VEGFR3 P35916 Vascular endothelial growth factor receptor 3 dto:DTO_03100562 A serine/threonine-protein kinase VRK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99986] https://pharos.nih.gov/idg/targets/Q99986 VRK1 Q99986 Serine/threonine-protein kinase vrk1 dto:DTO_03100563 A serine/threonine-protein kinase VRK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Y07] serine/threonine-protein kinase VRK2 (VRK2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q86Y07 VRK2 Q86Y07 Serine/threonine-protein kinase vrk2 dto:DTO_03100564 An inactive serine/threonine-protein kinase VRK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IV63] https://pharos.nih.gov/idg/targets/Q8IV63 VRK3 Q8IV63 Inactive serine/threonine-protein kinase vrk3 dto:DTO_03100565 A wee1-like protein kinase that is encoded in the genome of human. Wee1-like protein kinase (WEE1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P30291 WEE1 P30291 Wee1-like protein kinase dto:DTO_03100566 A wee1-like protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C1S8] Wee1-like protein kinase 2 (WEE2) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P0C1S8 WEE2 WEE1B P0C1S8 Wee1-like protein kinase 2 dto:DTO_03100567 A serine/threonine-protein kinase WNK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H4A3] serine/threonine-protein kinase wnk1 (WNK1) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9H4A3 WNK1 HSN2 KDP KIAA0344 PRKWNK1 Q9H4A3 Serine/threonine-protein kinase wnk1 dto:DTO_03100568 A serine/threonine-protein kinase WNK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3S1] https://pharos.nih.gov/idg/targets/Q9Y3S1 WNK2 KIAA1760 PRKWNK2 SDCCAG43 Q9Y3S1 Serine/threonine-protein kinase wnk2 dto:DTO_03100569 A serine/threonine-protein kinase WNK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BYP7] serine/threonine-protein kinase wnk3 (WNK3) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/Q9BYP7 WNK3 KIAA1566 PRKWNK3 Q9BYP7 Serine/threonine-protein kinase wnk3 dto:DTO_03100570 A serine/threonine-protein kinase WNK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96J92] https://pharos.nih.gov/idg/targets/Q96J92 WNK4 PRKWNK4 Q96J92 Serine/threonine-protein kinase wnk4 dto:DTO_03100571 A tyrosine-protein kinase Yes that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07947] tyrosine-protein kinase yes (YES) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P07947 YES1 YES P07947 Tyrosine-protein kinase yes dto:DTO_03100572 A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human. [PRO:CL, UniProtKB:P43403] tyrosine-protein kinase zap-70 (ZAP70) with no mutation in a nonphosphorylated state https://pharos.nih.gov/idg/targets/P43403 ZAP70 SRK P43403 Tyrosine-protein kinase zap-70 dto:DTO_03100573 ETNK1 Q9HBU6 Ethanolamine kinase 1 dto:DTO_03100574 ETNK2 Q9NVF9 Ethanolamine kinase 2 dto:DTO_03100575 GALK2 Q01415 N-acetylgalactosamine kinase dto:DTO_03100576 GALK1 P51570 Galactokinase dto:DTO_03100577 FUK Q8N0W3 L-fucose kinase dto:DTO_03100578 IDNK Q5T6J7 Probable gluconokinase dto:DTO_03100579 CMPK2 Q5EBM0 UMP-CMP kinase 2, mitochondrial dto:DTO_03100580 FGGY Q96C11 FGGY carbohydrate kinase domain-containing protein dto:DTO_03100581 FN3K Q9H479 Fructosamine-3-kinase dto:DTO_03100582 GK3P Q14409 Glycerol kinase 3 dto:DTO_03100583 GLYCTK Q8IVS8 Glycerate kinase dto:DTO_03100584 GK5 Q6ZS86 Putative glycerol kinase 5 dto:DTO_03100585 GK P32189 Glycerol kinase dto:DTO_03100586 HKDC1 Q2TB90 Putative hexokinase HKDC1 dto:DTO_03100587 HK3 P52790 Hexokinase-3 dto:DTO_03100588 HK2 P52789 Hexokinase-2 dto:DTO_03100589 ITPKC Q96DU7 Inositol-trisphosphate 3-kinase C dto:DTO_03100590 IP6K2 Q9UHH9 Inositol hexakisphosphate kinase 2 dto:DTO_03100591 AK8 Q96MA6 Adenylate kinase 8 dto:DTO_03100592 IP6K1 Q92551 Inositol hexakisphosphate kinase 1 dto:DTO_03100593 IP6K3 Q96PC2 Inositol hexakisphosphate kinase 3 dto:DTO_03100594 NMRK1 Q9NWW6 Nicotinamide riboside kinase 1 dto:DTO_03100595 PANK4 Q9NVE7 Pantothenate kinase 4 dto:DTO_03100596 CMPK1 P30085 UMP-CMP kinase dto:DTO_03100597 AK6 Q9Y3D8 Adenylate kinase isoenzyme 6 dto:DTO_03100598 AK5 Q9Y6K8 Adenylate kinase isoenzyme 5 dto:DTO_03100599 CKB P12277 Creatine kinase B-type dto:DTO_03100600 CKMT1A P12532 Creatine kinase U-type, mitochondrial dto:DTO_03100601 AK9 Q5TCS8 Adenylate kinase 9 dto:DTO_03100602 AK4 P27144 Adenylate kinase 4, mitochondrial dto:DTO_03100603 CKMT2 P17540 Creatine kinase S-type, mitochondrial dto:DTO_03100604 FN3KRP Q9HA64 Ketosamine-3-kinase dto:DTO_03100605 NADK O95544 NAD kinase dto:DTO_03100606 NADK2 Q4G0N4 NAD kinase 2, mitochondrial dto:DTO_03100607 NAGK Q9UJ70 N-acetyl-D-glucosamine kinase dto:DTO_03100608 NME1-NME2 P22392 Nucleoside diphosphate kinase B dto:DTO_03100609 NME5 P56597 Nucleoside diphosphate kinase homolog 5 dto:DTO_03100610 NME2P1 O60361 Putative nucleoside diphosphate kinase dto:DTO_03100611 NME3 Q13232 Nucleoside diphosphate kinase 3 dto:DTO_03100612 NME6 O75414 Nucleoside diphosphate kinase 6 dto:DTO_03100613 NME1 P15531 Nucleoside diphosphate kinase A dto:DTO_03100614 NME4 O00746 Nucleoside diphosphate kinase, mitochondrial dto:DTO_03100615 NMRK2 Q9NPI5 Nicotinamide riboside kinase 2 dto:DTO_03100616 PGK2 P07205 Phosphoglycerate kinase 2 dto:DTO_03100617 PCK1 P35558 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] dto:DTO_03100618 PFKM P08237 ATP-dependent 6-phosphofructokinase, muscle type dto:DTO_03100619 PFKP Q01813 ATP-dependent 6-phosphofructokinase, platelet type dto:DTO_03100620 PRPS1L1 P21108 Ribose-phosphate pyrophosphokinase 3 dto:DTO_03100621 PRPS2 P11908 Ribose-phosphate pyrophosphokinase 2 dto:DTO_03100622 PRPS1 P60891 Ribose-phosphate pyrophosphokinase 1 dto:DTO_03100623 PSTK Q8IV42 L-seryl-tRNA(Sec) kinase dto:DTO_03100624 SHPK Q9UHJ6 Sedoheptulokinase dto:DTO_03100625 RBKS Q9H477 Ribokinase dto:DTO_03100626 TBCK Q8TEA7 TBC domain-containing protein kinase-like protein dto:DTO_03100627 UCKL1 Q9NWZ5 Uridine-cytidine kinase-like 1 dto:DTO_03100628 XYLB O75191 Xylulose kinase dto:DTO_03100629 ADPGK Q9BRR6 ADP-dependent glucokinase dto:DTO_03100630 https://pharos.nih.gov/idg/targets/P16118 PFKFB1 P16118 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 dto:DTO_03100631 A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60825] https://pharos.nih.gov/idg/targets/O60825 PFKFB2 O60825 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 dto:DTO_03100632 A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16875] https://pharos.nih.gov/idg/targets/Q16875 PFKFB3 Q16875 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 dto:DTO_03100633 A pantothenate kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZ23] https://pharos.nih.gov/idg/targets/Q9BZ23 PANK2 Q9BZ23 Pantothenate kinase 2, mitochondrial dto:DTO_03100634 A pantothenate kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H999] https://pharos.nih.gov/idg/targets/Q9H999 PANK3 Q9H999 Pantothenate kinase 3 dto:DTO_03100635 A pyruvate kinase isozymes R/L that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30613] https://pharos.nih.gov/idg/targets/P30613 PKLR P30613 Pyruvate kinase PKLR dto:DTO_03100636 A serine/threonine-protein kinase RIO1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BRS2] https://pharos.nih.gov/idg/targets/Q9BRS2 RIOK1 Q9BRS2 Serine/threonine-protein kinase rio1 dto:DTO_03100637 A serine/threonine-protein kinase RIO3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14730] https://pharos.nih.gov/idg/targets/O14730 RIOK3 SUDD O14730 Serine/threonine-protein kinase rio3 dto:DTO_03200001 Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] 22848 AAK1 KIAA1048 AAK1 gene dto:DTO_03200002 The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008] 5564 PRKAB1 AMPK PRKAB1 gene dto:DTO_03200003 The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] 5571 PRKAG1 PRKAG1 gene dto:DTO_03200004 The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] 5562 PRKAA1 AMPK1 PRKAA1 gene dto:DTO_03200005 The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008] 5563 PRKAA2 AMPK AMPK2 PRKAA2 gene dto:DTO_03200006 This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] 25 ABL1 ABL JTK7 ABL1 gene dto:DTO_03200007 This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009] 27 ABL2 ABLL ARG ABL2 gene dto:DTO_03200008 This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008] 10188 TNK2 ACK1 TNK2 gene dto:DTO_03200009 This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010] 91 ACVR1B ACVRLK4 ALK4 ACVR1B gene dto:DTO_03200010 ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] 130399 ACVR1C ALK7 ACVR1C gene dto:DTO_03200011 This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008] 94 ACVRL1 ACVRLK1 ALK1 ACVRL1 gene dto:DTO_03200012 Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008] 90 ACVR1 ACVRLK2 ACVR1 gene dto:DTO_03200013 57143 ADCK1 ADCK1 gene dto:DTO_03200014 90956 ADCK2 AARF ADCK2 gene dto:DTO_03200015 This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008] 56997 ADCK3 CABC1 ADCK3 gene dto:DTO_03200016 This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] 79934 ADCK4 ADCK4 gene dto:DTO_03200017 203054 ADCK5 ADCK5 gene dto:DTO_03200018 This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] 132 ADK ADK gene dto:DTO_03200019 The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011] 207 AKT1 PKB RAC AKT1 gene dto:DTO_03200020 This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008] 208 AKT2 AKT2 gene dto:DTO_03200021 The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] 10000 AKT3 PKBG AKT3 gene dto:DTO_03200022 This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] 238 ALK ALK gene dto:DTO_03200023 This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] 80216 ALPK1 KIAA1527 LAK ALPK1 gene dto:DTO_03200024 115701 ALPK2 HAK ALPK2 gene dto:DTO_03200025 57538 ALPK3 KIAA1330 MAK ALPK3 gene dto:DTO_03200026 This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009] 269 AMHR2 AMHR MISR2 AMHR2 gene dto:DTO_03200027 The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009] 255239 ANKK1 PKK2 SGK288 ANKK1 gene dto:DTO_03200028 Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] 4881 NPR1 ANPRA NPR1 gene dto:DTO_03200029 This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008] 4882 NPR2 ANPRB NPR2 gene dto:DTO_03200030 This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012] 369 ARAF ARAF1 PKS PKS2 ARAF gene dto:DTO_03200031 The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008] 156 ADRBK1 BARK BARK1 GRK2 ADRBK1 gene dto:DTO_03200032 The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008] 157 ADRBK2 BARK2 GRK3 ADRBK2 gene dto:DTO_03200033 The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] 472 ATM ATM gene dto:DTO_03200034 The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008] 545 ATR FRP1 ATR gene dto:DTO_03200035 The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] 6790 AURKA AIK AIRK1 ARK1 AURKA gene dto:DTO_03200036 This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013] 9212 AURKB AIK2 AIM1 AIRK2 AURKB gene dto:DTO_03200037 This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] 6795 AURKC AIE2 AIK3 AIRK3 ARK3 AURKC gene dto:DTO_03200038 This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013] 92 ACVR2A ACVR2 ACVR2A gene dto:DTO_03200039 Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008] 93 ACVR2B ACVR2B gene dto:DTO_03200040 The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] 10295 BCKDK BCKDK gene dto:DTO_03200041 This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010] 640 BLK BLK gene dto:DTO_03200042 This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 55589 BMP2K BIKE BMP2K gene dto:DTO_03200043 This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008] 659 BMPR2 PPH1 BMPR2 gene dto:DTO_03200044 The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008] 657 BMPR1A ACVRLK3 ALK3 BMPR1A gene dto:DTO_03200045 This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] 658 BMPR1B BMPR1B gene dto:DTO_03200046 This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009] 660 BMX BMX gene dto:DTO_03200047 This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008] 673 BRAF BRAF1 RAFB1 BRAF gene dto:DTO_03200048 84446 BRSK1 KIAA1811 SAD1 SADB BRSK1 gene dto:DTO_03200049 9024 BRSK2 C11orf7 PEN11B SADA BRSK2 gene dto:DTO_03200050 The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] 695 BTK AGMX1 ATK BPK BTK gene dto:DTO_03200051 This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008] 701 BUB1B BUBR1 MAD3L SSK1 BUB1B gene dto:DTO_03200052 This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] 699 BUB1 BUB1L BUB1 gene dto:DTO_03200053 79012 CAMKV CAMKV gene dto:DTO_03200054 This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008] 728642 CDK11A CDC2L2 CDC2L3 PITSLREB CDK11A gene dto:DTO_03200055 This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] 984 CDK11B CDC2L1 CDK11 PITSLREA CDK11B gene dto:DTO_03200056 This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008] 8317 CDC7 CDC7L1 CDC7 gene dto:DTO_03200057 The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] 8558 CDK10 CDK10 gene dto:DTO_03200058 51755 CDK12 CRK7 CRKRS KIAA0904 CDK12 gene dto:DTO_03200059 The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009] 8621 CDK13 CDC2L CDC2L5 CHED CDK13 gene dto:DTO_03200060 PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008] 5218 CDK14 KIAA0834 PFTK1 CDK14 gene dto:DTO_03200061 65061 CDK15 ALS2CR7 PFTK2 CDK15 gene dto:DTO_03200062 The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009] 5127 CDK16 PCTAIRE1 PCTK1 CDK16 gene dto:DTO_03200063 The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010] 5128 CDK17 PCTAIRE2 PCTK2 CDK17 gene dto:DTO_03200064 5129 CDK18 PCTAIRE3 PCTK3 CDK18 gene dto:DTO_03200065 This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] 23097 CDK19 CDC2L6 CDK11 KIAA1028 CDK19 gene dto:DTO_03200066 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] 983 CDK1 CDC2 CDC28A CDKN1 CDK1 gene dto:DTO_03200067 The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009] 23552 CDK20 CCRK CDCH CDK20 gene dto:DTO_03200068 This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] 1017 CDK2 CDKN2 CDK2 gene dto:DTO_03200069 This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008] 1018 CDK3 CDKN3 CDK3 gene dto:DTO_03200070 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008] 1019 CDK4 CDK4 gene dto:DTO_03200071 1020 CDK5 CDKN5 CDK5 gene dto:DTO_03200072 The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] 1021 CDK6 CDKN6 CDK6 gene dto:DTO_03200073 The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008] 1022 CDK7 CAK CAK1 CDKN7 CDK7 gene dto:DTO_03200074 The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008] 1024 CDK8 CDK8 gene dto:DTO_03200075 The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008] 1025 CDK9 CDC2L4 TAK CDK9 gene dto:DTO_03200076 This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013] 8814 CDKL1 CDKL1 gene dto:DTO_03200077 This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008] 8999 CDKL2 CDKL2 gene dto:DTO_03200078 The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] 51265 CDKL3 NKIAMRE CDKL3 gene dto:DTO_03200079 344387 CDKL4 CDKL4 gene dto:DTO_03200080 This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] 6792 CDKL5 STK9 CDKL5 gene dto:DTO_03200081 CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008] 64781 CERK KIAA1646 CERK gene dto:DTO_03200082 The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011] 1111 CHEK1 CHK1 CHEK1 gene dto:DTO_03200083 In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] 11200 CHEK2 CDS1 CHK2 RAD53 CHEK2 gene dto:DTO_03200084 The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 1119 CHKA CHK CKI CHKA gene dto:DTO_03200085 Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009] 1120 CHKB CHETK CHKL CHKB gene dto:DTO_03200086 This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] 1195 CLK1 CLK CLK1 gene dto:DTO_03200087 This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] 1196 CLK2 CLK2 gene dto:DTO_03200088 This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008] 1198 CLK3 CLK3 gene dto:DTO_03200089 The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008] 57396 CLK4 CLK4 gene dto:DTO_03200090 The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] 1436 CSF1R FMS CSF1R gene dto:DTO_03200091 Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014] 1457 CSNK2A1 CK2A1 CSNK2A1 gene dto:DTO_03200092 1459 CSNK2A2 CK2A2 CSNK2A2 gene dto:DTO_03200093 This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012] 283106 CSNK2A3 CSNK2A1P CSNK2A3 gene dto:DTO_03200094 This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] 1460 CSNK2B CK2N G5A CSNK2B gene dto:DTO_03200095 This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010] 8573 CASK LIN2 CASK gene dto:DTO_03200096 1445 CSK CSK gene dto:DTO_03200097 This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] 11113 CIT CRIK KIAA0949 STK21 CIT gene dto:DTO_03200098 Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] 1612 DAPK1 DAPK DAPK1 gene dto:DTO_03200099 This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008] 23604 DAPK2 DAPK2 gene dto:DTO_03200100 Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008] 1613 DAPK3 ZIPK DAPK3 gene dto:DTO_03200101 Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008] 1633 DCK DCK gene dto:DTO_03200102 This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010] 9201 DCLK1 DCAMKL1 DCDC3A KIAA0369 DCLK1 gene dto:DTO_03200103 This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010] 166614 DCLK2 DCAMKL2 DCDC3B DCK2 DCLK2 gene dto:DTO_03200104 85443 DCLK3 DCAMKL3 DCDC3C KIAA1765 DCLK3 gene dto:DTO_03200105 Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] 780 DDR1 CAK EDDR1 NEP DDR1 gene dto:DTO_03200106 Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] 4921 DDR2 NTRKR3 TKT TYRO10 DDR2 gene dto:DTO_03200107 The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] 1606 DGKA DAGK DAGK1 DGKA gene dto:DTO_03200108 This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014] 160851 DGKH DGKH gene dto:DTO_03200109 The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008] 1609 DGKQ DAGK4 DGKQ gene dto:DTO_03200110 In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] 1716 DGUOK DGK DGUOK gene dto:DTO_03200111 The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] 1760 DMPK DM1PK MDPK DMPK gene dto:DTO_03200112 This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] 25778 DSTYK KIAA0472 RIP5 RIPK5 DSTYK gene dto:DTO_03200113 This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] 1859 DYRK1A DYRK MNB MNBH DYRK1A gene dto:DTO_03200114 This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] 9149 DYRK1B MIRK DYRK1B gene dto:DTO_03200115 DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008] 8445 DYRK2 DYRK2 gene dto:DTO_03200116 This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 8444 DYRK3 DYRK3 gene dto:DTO_03200117 This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013] 8798 DYRK4 DYRK4 gene dto:DTO_03200118 The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] 27102 EIF2AK1 HRI KIAA1369 EIF2AK1 gene dto:DTO_03200119 The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] 5610 EIF2AK2 PKR PRKR EIF2AK2 gene dto:DTO_03200120 The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010] 9451 EIF2AK3 PEK PERK EIF2AK3 gene dto:DTO_03200121 This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014] 440275 EIF2AK4 GCN2 KIAA1338 EIF2AK4 gene dto:DTO_03200122 This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008] 101930123 29904 EEF2K EEF2K gene dto:DTO_03200123 This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008] 1942 EFNA1 EPLG1 LERK1 TNFAIP4 EFNA1 gene dto:DTO_03200124 The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010] 1956 EGFR ERBB ERBB1 HER1 EGFR gene dto:DTO_03200125 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008] 2041 EPHA1 EPH EPHT EPHT1 EPHA1 gene dto:DTO_03200126 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010] 1969 EPHA2 ECK EPHA2 gene dto:DTO_03200127 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] 2042 EPHA3 ETK ETK1 HEK EPHA3 gene dto:DTO_03200128 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008] 2043 EPHA4 HEK8 SEK TYRO1 EPHA4 gene dto:DTO_03200129 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013] 2044 EPHA5 BSK EHK1 HEK7 EPHA5 gene dto:DTO_03200130 285220 EPHA6 EHK2 HEK12 EPHA6 gene dto:DTO_03200131 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] 2045 EPHA7 EHK3 HEK11 EPHA7 gene dto:DTO_03200132 This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008] 2046 EPHA8 EEK HEK3 KIAA1459 EPHA8 gene dto:DTO_03200133 Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008] 284656 EPHA10 EPHA10 gene dto:DTO_03200134 Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008] 2047 EPHB1 ELK EPHT2 HEK6 EPHB1 gene dto:DTO_03200135 Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008] 2048 EPHB2 DRT EPHT3 EPTH3 EPHB2 gene dto:DTO_03200136 Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010] 2049 EPHB3 ETK2 HEK2 TYRO6 EPHB3 gene dto:DTO_03200137 Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008] 2050 EPHB4 HTK MYK1 TYRO11 EPHB4 gene dto:DTO_03200138 This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] 2051 EPHB6 EPHB6 gene dto:DTO_03200139 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] 2064 ERBB2 HER2 MLN19 NEU ERBB2 gene dto:DTO_03200140 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] 2065 ERBB3 HER3 ERBB3 gene dto:DTO_03200141 This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] 2066 ERBB4 HER4 ERBB4 gene dto:DTO_03200142 The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008] 2081 ERN1 IRE1 ERN1 gene dto:DTO_03200143 10595 ERN2 IRE2 ERN2 gene dto:DTO_03200144 This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010] 5747 PTK2 FAK FAK1 PTK2 gene dto:DTO_03200145 This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 2185 PTK2B FAK2 PYK2 RAFTK PTK2B gene dto:DTO_03200146 The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008] 10922 FASTK FASTK gene dto:DTO_03200147 Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008] 2241 FER TYK3 FER gene dto:DTO_03200148 This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009] 2242 FES FPS FES gene dto:DTO_03200149 The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] 2260 FGFR1 BFGFR CEK FGFBR FGFR1 gene dto:DTO_03200150 The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] 2263 FGFR2 BEK KGFR KSAM FGFR2 gene dto:DTO_03200151 This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009] 2261 FGFR3 JTK4 FGFR3 gene dto:DTO_03200152 The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008] 2264 FGFR4 JTK2 TKF FGFR4 gene dto:DTO_03200153 This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] 2268 FGR SRC2 FGR gene dto:DTO_03200154 This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008] 2322 FLT3 CD135 FLK2 STK1 FLT3 gene dto:DTO_03200155 The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008] 2444 FRK PTK5 RAK FRK gene dto:DTO_03200156 This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008] 2534 FYN FYN gene dto:DTO_03200157 Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] 200576 PIKFYVE KIAA0981 PIP5K3 PIKFYVE gene dto:DTO_03200158 In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] 2580 GAK GAK gene dto:DTO_03200159 2712 GK2 GKP2 GKTA GK2 gene dto:DTO_03200160 This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] 2868 GRK4 GPRK2L GPRK4 GRK4 gene dto:DTO_03200161 This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008] 2869 GRK5 GPRK5 GRK5 gene dto:DTO_03200162 This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] 2870 GRK6 GPRK6 GRK6 gene dto:DTO_03200163 This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008] 131890 GRK7 GPRK7 GRK7 gene dto:DTO_03200164 This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011] 2931 GSK3A GSK3A gene dto:DTO_03200165 The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] 2932 GSK3B GSK3B gene dto:DTO_03200166 2984 GUCY2C GUC2C STAR GUCY2C gene dto:DTO_03200167 This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008] 3000 GUCY2D CORD6 GUC1A4 GUC2D GUCY2D gene dto:DTO_03200168 The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008] 2986 GUCY2F GUC2F RETGC2 GUCY2F gene dto:DTO_03200169 This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010] 84930 MASTL GW GWL THC2 MASTL gene dto:DTO_03200170 83903 GSG2 GSG2 gene dto:DTO_03200171 The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010] 3055 HCK HCK gene dto:DTO_03200172 The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008] 204851 HIPK1 KIAA0630 MYAK NBAK2 HIPK1 gene dto:DTO_03200173 This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] 28996 HIPK2 HIPK2 gene dto:DTO_03200174 10114 HIPK3 DYRK6 FIST3 PKY HIPK3 gene dto:DTO_03200175 147746 HIPK4 HIPK4 gene dto:DTO_03200176 30811 HUNK MAKV HUNK gene dto:DTO_03200177 Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009] 3098 HK1 HK1 gene dto:DTO_03200178 Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009] 2645 GCK GCK gene dto:DTO_03200179 Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008] 22858 ICK KIAA0936 ICK gene dto:DTO_03200180 This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] 3480 IGF1R IGF1R gene dto:DTO_03200181 This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008] 1147 CHUK IKKA TCF16 CHUK gene dto:DTO_03200182 The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] 3551 IKBKB IKKB IKBKB gene dto:DTO_03200183 IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] 9641 IKBKE IKKE IKKI KIAA0151 IKBKE gene dto:DTO_03200184 This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] 3611 ILK ILK1 ILK2 ILK gene dto:DTO_03200185 3645 INSRR IRR INSRR gene dto:DTO_03200186 After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 3643 INSR INSR gene dto:DTO_03200187 Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011] 3706 ITPKA ITPKA gene dto:DTO_03200188 The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008] 3707 ITPKB ITPKB gene dto:DTO_03200189 This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010] 253430 IPMK IMPK IPMK gene dto:DTO_03200190 This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 3654 IRAK1 IRAK IRAK1 gene dto:DTO_03200191 IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008] 3656 IRAK2 IRAK2 gene dto:DTO_03200192 This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] 11213 IRAK3 IRAK3 gene dto:DTO_03200193 This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] 51135 IRAK4 IRAK4 gene dto:DTO_03200194 This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008] 3702 ITK EMT LYK ITK gene dto:DTO_03200195 3705 ITPK1 ITPK1 gene dto:DTO_03200196 Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008] 3716 JAK1 JAK1A JAK1B JAK1 gene dto:DTO_03200197 This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008] 3717 JAK2 JAK2 gene dto:DTO_03200198 The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] 3718 JAK3 JAK3 gene dto:DTO_03200199 This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] 5211 PFKL PFKL gene dto:DTO_03200200 Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008] 203 AK1 AK1 gene dto:DTO_03200201 Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010] 204 AK2 ADK2 AK2 gene dto:DTO_03200202 The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010] 50808 AK3 AK3L1 AK6 AKL3L AK3 gene dto:DTO_03200203 Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] 8997 KALRN DUET DUO HAPIP KALRN gene dto:DTO_03200204 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] 5566 PRKACA PKACA PRKACA gene dto:DTO_03200205 The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014] 5567 PRKACB PRKACB gene dto:DTO_03200206 Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008] 5568 PRKACG PRKACG gene dto:DTO_03200207 122011 CSNK1A1L CSNK1A1L gene dto:DTO_03200208 1452 CSNK1A1 CSNK1A1 gene dto:DTO_03200209 This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014] 1453 CSNK1D HCKID CSNK1D gene dto:DTO_03200210 The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014] 102800317 1454 CSNK1E CSNK1E gene dto:DTO_03200211 This gene encodes a member of the casein kinase I gene family. The encoded protein is a serine/threonine kinase that phosphorylates acidic proteins, and participates in pathways for cell growth. [provided by RefSeq, Nov 2011] 53944 CSNK1G1 CSNK1G1 gene dto:DTO_03200212 1455 CSNK1G2 CK1G2 CSNK1G2 gene dto:DTO_03200213 This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] 1456 CSNK1G3 CSNK1G3 gene dto:DTO_03200214 Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008] 8536 CAMK1 CAMK1 gene dto:DTO_03200215 PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008] 139728 PNCK PNCK gene dto:DTO_03200216 This gene encodes a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of serine/threonine kinases. The encoded protein may be involved in the regulation of granulocyte function through the chemokine signal transduction pathway. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008] 57118 CAMK1D CAMKID CAMK1D gene dto:DTO_03200217 This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008] 57172 CAMK1G CLICK3 VWS1 CAMK1G gene dto:DTO_03200218 The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008] 815 CAMK2A CAMKA KIAA0968 CAMK2A gene dto:DTO_03200219 The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] 816 CAMK2B CAM2 CAMK2 CAMKB CAMK2B gene dto:DTO_03200220 The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008] 817 CAMK2D CAMKD CAMK2D gene dto:DTO_03200221 The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011] 818 CAMK2G CAMK CAMK-II CAMKG CAMK2G gene dto:DTO_03200222 The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008] 814 CAMK4 CAMK CAMK-GR CAMKIV CAMK4 gene dto:DTO_03200223 The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008] 1158 CKM CKMM CKM gene dto:DTO_03200224 Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011] 5592 PRKG1 PRKG1B PRKGR1A PRKGR1B PRKG1 gene dto:DTO_03200225 This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] 5593 PRKG2 PRKGR2 PRKG2 gene dto:DTO_03200226 The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] 2987 GUK1 GMK GUK1 gene dto:DTO_03200227 This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 3795 KHK KHK gene dto:DTO_03200228 This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] 4598 MVK MVK gene dto:DTO_03200229 7083 TK1 TK1 gene dto:DTO_03200230 This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012] 7084 TK2 TK2 gene dto:DTO_03200231 This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 3815 KIT SCFR KIT gene dto:DTO_03200232 The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] 84254 CAMKK1 CAMKKA CAMKK1 gene dto:DTO_03200233 The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012] 10645 CAMKK2 CAMKKB KIAA0787 CAMKK2 gene dto:DTO_03200234 Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010] 5255 PHKA1 PHKA PHKA1 gene dto:DTO_03200235 Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined.[provided by RefSeq, Feb 2010] 5256 PHKA2 PHKLA PYK PHKA2 gene dto:DTO_03200236 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008] 5578 PRKCA PKCA PRKACA PRKCA gene dto:DTO_03200237 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] 5579 PRKCB PKCB PRKCB1 PRKCB gene dto:DTO_03200238 PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010] 5587 PRKD1 PKD PKD1 PRKCM PRKD1 gene dto:DTO_03200239 The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] 25865 PRKD2 PKD2 PRKD2 gene dto:DTO_03200240 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008] 23683 PRKD3 EPK2 PRKCN PRKD3 gene dto:DTO_03200241 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] 5580 PRKCD PRKCD gene dto:DTO_03200242 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008] 5581 PRKCE PKCE PRKCE gene dto:DTO_03200243 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008] 5582 PRKCG PKCG PRKCG gene dto:DTO_03200244 This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008] 5584 PRKCI DXS1179E PRKCI gene dto:DTO_03200245 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008] 5583 PRKCH PKCL PRKCL PRKCH gene dto:DTO_03200246 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008] 5588 PRKCQ PRKCT PRKCQ gene dto:DTO_03200247 Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] 5590 PRKCZ PKC2 PRKCZ gene dto:DTO_03200248 5681 PSKH1 PSKH1 gene dto:DTO_03200249 85481 PSKH2 PSKH2 gene dto:DTO_03200250 This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011] 5315 PKM OIP3 PK2 PK3 PKM gene dto:DTO_03200251 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] 6195 RPS6KA1 MAPKAPK1A RSK1 RPS6KA1 gene dto:DTO_03200252 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] 6196 RPS6KA2 MAPKAPK1C RSK3 RPS6KA2 gene dto:DTO_03200253 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008] 6197 RPS6KA3 ISPK1 MAPKAPK1B RSK2 RPS6KA3 gene dto:DTO_03200254 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] 8986 RPS6KA4 MSK2 RPS6KA4 gene dto:DTO_03200255 9252 RPS6KA5 MSK1 RPS6KA5 gene dto:DTO_03200256 This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010] 27330 RPS6KA6 RSK4 RPS6KA6 gene dto:DTO_03200257 This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013] 6198 RPS6KB1 STK14A RPS6KB1 gene dto:DTO_03200258 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jul 2008] 6199 RPS6KB2 STK14B RPS6KB2 gene dto:DTO_03200259 26750 RPS6KC1 RPK118 RPS6KC1 gene dto:DTO_03200260 8844 KSR1 KSR KSR1 gene dto:DTO_03200261 283455 KSR2 KSR2 gene dto:DTO_03200262 This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] 6850 SYK SYK gene dto:DTO_03200263 1841 DTYMK CDC8 TMPK TYMK DTYMK gene dto:DTO_03200264 The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012] 9113 LATS1 WARTS LATS1 gene dto:DTO_03200265 This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008] 26524 LATS2 KPM LATS2 gene dto:DTO_03200266 This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008] 3932 LCK LCK gene dto:DTO_03200267 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011] 3984 LIMK1 LIMK LIMK1 gene dto:DTO_03200268 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 3985 LIMK2 LIMK2 gene dto:DTO_03200269 The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] 9625 AATK AATYK KIAA0641 LMR1 AATK gene dto:DTO_03200270 The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009] 22853 LMTK2 AATYK2 BREK KIAA1079 LMTK2 gene dto:DTO_03200271 114783 LMTK3 KIAA1883 TYKLM3 LMTK3 gene dto:DTO_03200272 79705 LRRK1 KIAA1790 LRRK1 gene dto:DTO_03200273 This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] 120892 LRRK2 PARK8 LRRK2 gene dto:DTO_03200274 The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] 4058 LTK TYK1 LTK gene dto:DTO_03200275 This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] 4067 LYN JTK8 LYN gene dto:DTO_03200276 The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008] 4294 MAP3K10 MLK2 MST MAP3K10 gene dto:DTO_03200277 The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008] 4296 MAP3K11 MLK3 PTK1 SPRK MAP3K11 gene dto:DTO_03200278 This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010] 7786 MAP3K12 ZPK MAP3K12 gene dto:DTO_03200279 The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008] 9175 MAP3K13 LZK MAP3K13 gene dto:DTO_03200280 This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008] 9020 MAP3K14 NIK MAP3K14 gene dto:DTO_03200281 The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010] 389840 MAP3K15 ASK3 MAP3K15 gene dto:DTO_03200282 80122 MAP3K19 RCK YSK4 MAP3K19 gene dto:DTO_03200283 The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] 4214 MAP3K1 MAPKKK1 MEKK MEKK1 MAP3K1 gene dto:DTO_03200284 The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008] 10746 MAP3K2 MAPKKK2 MEKK2 MAP3K2 gene dto:DTO_03200285 This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] 4215 MAP3K3 MAPKKK3 MEKK3 MAP3K3 gene dto:DTO_03200286 The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014] 4216 MAP3K4 KIAA0213 MAPKKK4 MEKK4 MAP3K4 gene dto:DTO_03200287 Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] 4217 MAP3K5 ASK1 MAPKKK5 MEKK5 MAP3K5 gene dto:DTO_03200288 This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] 9064 MAP3K6 ASK2 MAPKKK6 MEKK6 MAP3K6 gene dto:DTO_03200289 The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] 6885 MAP3K7 TAK1 MAP3K7 gene dto:DTO_03200290 This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] 1326 MAP3K8 COT ESTF MAP3K8 gene dto:DTO_03200291 4293 MAP3K9 MLK1 PRKE1 MAP3K9 gene dto:DTO_03200292 84451 MLK4 KIAA1804 MLK4 gene dto:DTO_03200293 11184 MAP4K1 HPK1 MAP4K1 gene dto:DTO_03200294 The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008] 5871 MAP4K2 GCK RAB8IP MAP4K2 gene dto:DTO_03200295 This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] 8491 MAP4K3 RAB8IPL1 MAP4K3 gene dto:DTO_03200296 The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 9448 MAP4K4 HGK KIAA0687 NIK MAP4K4 gene dto:DTO_03200297 This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008] 11183 MAP4K5 MAP4K5 gene dto:DTO_03200298 The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] 4117 MAK MAK gene dto:DTO_03200299 This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 9261 MAPKAPK2 MAPKAPK2 gene dto:DTO_03200300 This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] 7867 MAPKAPK3 MAPKAPK3 gene dto:DTO_03200301 The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012] 8550 MAPKAPK5 PRAK MAPKAPK5 gene dto:DTO_03200302 4139 MARK1 KIAA1477 MARK MARK1 gene dto:DTO_03200303 This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009] 2011 MARK2 EMK1 MARK2 gene dto:DTO_03200304 The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] 4140 MARK3 CTAK1 EMK2 MARK3 gene dto:DTO_03200305 This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] 57787 MARK4 KIAA1860 MARKL1 MARK4 gene dto:DTO_03200306 22983 MAST1 KIAA0973 SAST MAST1 gene dto:DTO_03200307 23139 MAST2 KIAA0807 MAST205 MAST2 gene dto:DTO_03200308 23031 MAST3 KIAA0561 MAST3 gene dto:DTO_03200309 This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014] 375449 MAST4 KIAA0303 MAST4 gene dto:DTO_03200310 The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] 4145 MATK CTK HYL MATK gene dto:DTO_03200311 9833 MELK KIAA0175 MELK gene dto:DTO_03200312 This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] 10461 MERTK MER MERTK gene dto:DTO_03200313 The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 4233 MET MET gene dto:DTO_03200314 This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] 50488 MINK1 B55 MAP4K6 MINK MINK1 gene dto:DTO_03200315 This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014] 5594 MAPK1 ERK2 PRKM1 PRKM2 MAPK1 gene dto:DTO_03200316 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008] 5595 MAPK3 ERK1 PRKM3 MAPK3 gene dto:DTO_03200317 Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] 5596 MAPK4 ERK4 PRKM4 MAPK4 gene dto:DTO_03200318 The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008] 5597 MAPK6 ERK3 PRKM6 MAPK6 gene dto:DTO_03200319 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008] 5598 MAPK7 BMK1 ERK5 PRKM7 MAPK7 gene dto:DTO_03200320 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013] 5599 MAPK8 JNK1 PRKM8 SAPK1 MAPK8 gene dto:DTO_03200321 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008] 5601 MAPK9 JNK2 PRKM9 SAPK1A MAPK9 gene dto:DTO_03200322 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] 5602 MAPK10 JNK3 JNK3A PRKM10 MAPK10 gene dto:DTO_03200323 This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] 5600 MAPK11 PRKM11 SAPK2 SAPK2B MAPK11 gene dto:DTO_03200324 Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008] 6300 MAPK12 ERK6 SAPK3 MAPK12 gene dto:DTO_03200325 This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] 5603 MAPK13 PRKM13 SAPK4 MAPK13 gene dto:DTO_03200326 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] 1432 MAPK14 CSBP CSBP1 CSBP2 MAPK14 gene dto:DTO_03200327 225689 MAPK15 ERK7 ERK8 MAPK15 gene dto:DTO_03200328 This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012] 8569 MKNK1 MNK1 MKNK1 gene dto:DTO_03200329 This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011] 2872 MKNK2 GPRK7 MNK2 MKNK2 gene dto:DTO_03200330 197259 MLKL MLKL gene dto:DTO_03200331 This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] 51776 ZAK MLTK ZAK gene dto:DTO_03200332 This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012] 5891 MOK RAGE RAGE1 MOK gene dto:DTO_03200333 MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009] 4342 MOS MOS gene dto:DTO_03200334 The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008] 5604 MAP2K1 MEK1 PRKMK1 MAP2K1 gene dto:DTO_03200335 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008] 5605 MAP2K2 MEK2 MKK2 PRKMK2 MAP2K2 gene dto:DTO_03200336 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] 5606 MAP2K3 MEK3 MKK3 PRKMK3 MAP2K3 gene dto:DTO_03200337 This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] 6416 MAP2K4 JNKK1 MEK4 MKK4 MAP2K4 gene dto:DTO_03200338 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011] 5607 MAP2K5 MEK5 MKK5 PRKMK5 MAP2K5 gene dto:DTO_03200339 This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008] 5608 MAP2K6 MEK6 MKK6 PRKMK6 MAP2K6 gene dto:DTO_03200340 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] 5609 MAP2K7 JNKK2 MEK7 MKK7 MAP2K7 gene dto:DTO_03200341 The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008] 8476 CDC42BPA KIAA0451 CDC42BPA gene dto:DTO_03200342 This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008] 9578 CDC42BPB KIAA1124 CDC42BPB gene dto:DTO_03200343 55561 CDC42BPG DMPK2 CDC42BPG gene dto:DTO_03200344 The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] 51765 MST4 MASK MST4 MST4 gene dto:DTO_03200345 The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] 2475 MTOR FRAP FRAP1 FRAP2 RAFT1 MTOR gene dto:DTO_03200346 This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009] 4593 MUSK MUSK gene dto:DTO_03200347 This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008] 85366 MYLK2 MYLK2 gene dto:DTO_03200348 Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008] 91807 MYLK3 MLCK MYLK3 gene dto:DTO_03200349 340156 MYLK4 SGK085 MYLK4 gene dto:DTO_03200350 This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008] 4638 MYLK MLCK MLCK1 MYLK1 MYLK gene dto:DTO_03200351 The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008] 53904 MYO3A MYO3A gene dto:DTO_03200352 This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014] 140469 MYO3B MYO3B gene dto:DTO_03200353 152110 NEK10 NEK10 gene dto:DTO_03200354 This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009] 79858 NEK11 NEK11 gene dto:DTO_03200355 The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010] 4750 NEK1 KIAA1901 NEK1 gene dto:DTO_03200356 This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011] 4751 NEK2 NEK2A NLK1 NEK2 gene dto:DTO_03200357 This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] 4752 NEK3 NEK3 gene dto:DTO_03200358 6787 NEK4 STK2 NEK4 gene dto:DTO_03200359 341676 NEK5 NEK5 gene dto:DTO_03200360 The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] 10783 NEK6 NEK6 gene dto:DTO_03200361 NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002] 140609 NEK7 NEK7 gene dto:DTO_03200362 This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008] 284086 NEK8 JCK NEK12A NEK8 gene dto:DTO_03200363 91754 NEK9 KIAA1995 NEK8 NERCC NEK9 gene dto:DTO_03200364 This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011] 8517 IKBKG FIP3 NEMO IKBKG gene dto:DTO_03200365 167359 NIM1K NIM1 NIM1K gene dto:DTO_03200366 51701 NLK LAK1 NLK gene dto:DTO_03200367 340371 NRBP2 NRBP2 gene dto:DTO_03200368 29959 NRBP1 BCON3 NRBP NRBP1 gene dto:DTO_03200369 The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010] 203447 NRK NRK gene dto:DTO_03200370 This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 57410 SCYL1 CVAK90 GKLP NTKL SCYL1 gene dto:DTO_03200371 This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008] 4914 NTRK1 MTC TRK TRKA NTRK1 gene dto:DTO_03200372 This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] 4915 NTRK2 TRKB NTRK2 gene dto:DTO_03200373 This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] 4916 NTRK3 TRKC NTRK3 gene dto:DTO_03200374 9891 NUAK1 ARK5 KIAA0537 OMPHK1 NUAK1 gene dto:DTO_03200375 81788 NUAK2 OMPHK2 SNARK NUAK2 gene dto:DTO_03200376 The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 84033 OBSCN KIAA1556 KIAA1639 OBSCN gene dto:DTO_03200377 The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008] 9943 OXSR1 KIAA1101 OSR1 OXSR1 gene dto:DTO_03200378 The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008] 5286 PIK3C2A PIK3C2A gene dto:DTO_03200379 The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008] 5287 PIK3C2B PIK3C2B gene dto:DTO_03200380 The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] 5288 PIK3C2G PIK3C2G gene dto:DTO_03200381 Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008] 55361 PI4K2A PI4K2A gene dto:DTO_03200382 Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] 5295 PIK3R1 GRB1 PIK3R1 gene dto:DTO_03200383 This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012] 57147 SCYL3 PACE1 SCYL3 gene dto:DTO_03200384 This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] 5058 PAK1 PAK1 gene dto:DTO_03200385 The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008] 5062 PAK2 PAK2 gene dto:DTO_03200386 PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] 5063 PAK3 OPHN3 PAK3 gene dto:DTO_03200387 PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 10298 PAK4 KIAA1142 PAK4 gene dto:DTO_03200388 This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] 56924 PAK6 PAK5 PAK6 gene dto:DTO_03200389 The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] 57144 PAK7 KIAA1264 PAK5 PAK7 gene dto:DTO_03200390 255967 PAN3 PAN3 gene dto:DTO_03200391 This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011] 53354 PANK1 PANK PANK1 gene dto:DTO_03200392 This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] 23178 PASK KIAA0135 PASK gene dto:DTO_03200393 This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014] 5106 PCK2 PEPCK2 PCK2 gene dto:DTO_03200394 149420 PDIK1L CLIK1L PDIK1L gene dto:DTO_03200395 Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013] 5163 PDK1 PDHK1 PDK1 gene dto:DTO_03200396 This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] 5164 PDK2 PDHK2 PDK2 gene dto:DTO_03200397 The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] 5165 PDK3 PDHK3 PDK3 gene dto:DTO_03200398 This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008] 5166 PDK4 PDHK4 PDK4 gene dto:DTO_03200399 5170 PDPK1 PDK1 PDPK1 gene dto:DTO_03200400 653650 PDPK2P PDPK2 PDPK2P gene dto:DTO_03200401 The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] 8566 PDXK C21orf124 C21orf97 PKH PDXK gene dto:DTO_03200402 This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014] 79834 PEAK1 KIAA2002 PEAK1 gene dto:DTO_03200403 This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012] 5156 PDGFRA PDGFR2 RHEPDGFRA PDGFRA gene dto:DTO_03200404 This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008] 5159 PDGFRB PDGFR PDGFR1 PDGFRB gene dto:DTO_03200405 The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014] 5230 PGK1 PGKA PGK1 gene dto:DTO_03200406 This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] 5260 PHKG1 PHKG PHKG1 gene dto:DTO_03200407 Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] 5261 PHKG2 PHKG2 gene dto:DTO_03200408 30849 PIK3R4 PIK3R4 gene dto:DTO_03200409 Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008] 5305 PIP4K2A PIP5K2 PIP5K2A PIP4K2A gene dto:DTO_03200410 The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008] 8396 PIP4K2B PIP5K2B PIP4K2B gene dto:DTO_03200411 79837 PIP4K2C PIP5K2C PIP4K2C gene dto:DTO_03200412 This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014] 5297 PI4KA PIK4 PIK4CA PI4KA gene dto:DTO_03200413 5298 PI4KB PIK4CB PI4KB gene dto:DTO_03200414 8394 PIP5K1A PIP5K1A gene dto:DTO_03200415 8395 PIP5K1B STM7 PIP5K1B gene dto:DTO_03200416 This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010] 23396 PIP5K1C KIAA0589 PIP5K1C gene dto:DTO_03200417 The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011] 5292 PIM1 PIM1 gene dto:DTO_03200418 This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009] 11040 PIM2 PIM2 gene dto:DTO_03200419 The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012] 415116 PIM3 PIM3 gene dto:DTO_03200420 This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] 65018 PINK1 PINK1 gene dto:DTO_03200421 5289 PIK3C3 VPS34 PIK3C3 gene dto:DTO_03200422 Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008] 5290 PIK3CA PIK3CA gene dto:DTO_03200423 This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] 5291 PIK3CB PIK3C1 PIK3CB gene dto:DTO_03200424 Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010] 5293 PIK3CD PIK3CD gene dto:DTO_03200425 This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] 5294 PIK3CG PIK3CG gene dto:DTO_03200426 91461 PKDCC SGK493 VLK PKDCC gene dto:DTO_03200427 The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] 5585 PKN1 PAK1 PKN PRK1 PKN1 gene dto:DTO_03200428 5586 PKN2 PRK2 PRKCL2 PKN2 gene dto:DTO_03200429 29941 PKN3 PKNBETA PKN3 gene dto:DTO_03200430 5347 PLK1 PLK PLK1 gene dto:DTO_03200431 The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] 10769 PLK2 SNK PLK2 gene dto:DTO_03200432 Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis. [provided by RefSeq, Jul 2008] 1263 PLK3 CNK FNK PRK PLK3 gene dto:DTO_03200433 This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010] 10733 PLK4 SAK STK18 PLK4 gene dto:DTO_03200434 126520 PLK5 PLK5P PLK5 gene dto:DTO_03200435 This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] 9088 PKMYT1 MYT1 PKMYT1 gene dto:DTO_03200436 This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010] 5591 PRKDC HYRC HYRC1 PRKDC gene dto:DTO_03200437 This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] 8575 PRKRA PACT RAX PRKRA gene dto:DTO_03200438 This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010] 5613 PRKX PKX1 PRKX gene dto:DTO_03200439 This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010] 5616 PRKY PRKY gene dto:DTO_03200440 Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008] 8899 PRPF4B KIAA0536 PRP4 PRP4H PRPF4B gene dto:DTO_03200441 112858 TP53RK C20orf64 PRPK TP53RK gene dto:DTO_03200442 The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] 5753 PTK6 BRK PTK6 gene dto:DTO_03200443 This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] 5754 PTK7 CCK4 PTK7 gene dto:DTO_03200444 This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] 54899 PXK PXK gene dto:DTO_03200445 This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] 5894 RAF1 RAF RAF1 gene dto:DTO_03200446 This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008] 5979 RET CDHF12 CDHR16 PTC RET gene dto:DTO_03200448 55781 RIOK2 RIOK2 gene dto:DTO_03200450 8737 RIPK1 RIP RIP1 RIPK1 gene dto:DTO_03200451 This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008] 8767 RIPK2 CARDIAK RICK RIP2 RIPK2 gene dto:DTO_03200452 The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008] 11035 RIPK3 RIP3 RIPK3 gene dto:DTO_03200453 The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008] 54101 RIPK4 ANKRD3 DIK RIPK4 gene dto:DTO_03200454 This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008] 6011 GRK1 RHOK GRK1 gene dto:DTO_03200455 This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008] 6041 RNASEL RNS4 RNASEL gene dto:DTO_03200456 This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008] 6093 ROCK1 ROCK1 gene dto:DTO_03200457 The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008] 9475 ROCK2 KIAA0619 ROCK2 gene dto:DTO_03200458 This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011] 4486 MST1R PTK8 RON MST1R gene dto:DTO_03200459 This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] 4919 ROR1 NTRKR1 ROR1 gene dto:DTO_03200460 The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008] 4920 ROR2 NTRKR2 ROR2 gene dto:DTO_03200461 This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008] 6098 ROS1 MCF3 ROS ROS1 gene dto:DTO_03200462 83694 RPS6KL1 RPS6KL1 gene dto:DTO_03200463 The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012] 6259 RYK JTK5A RYK gene dto:DTO_03200464 388228 SBK1 SBK1 gene dto:DTO_03200465 646643 SBK2 SGK069 SBK2 gene dto:DTO_03200466 100130827 SBK3 SGK110 SBK3 gene dto:DTO_03200467 55681 SCYL2 CVAK104 KIAA1360 SCYL2 gene dto:DTO_03200468 This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] 84197 POMK SGK196 POMK gene dto:DTO_03200469 This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014] 157285 SGK223 SGK223 gene dto:DTO_03200470 124923 SGK494 SGK494 gene dto:DTO_03200471 This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] 6446 SGK1 SGK SGK1 gene dto:DTO_03200472 This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] 10110 SGK2 SGK2 gene dto:DTO_03200473 This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] 100533105 23678 SGK3 CISK SGKL SGK3 gene dto:DTO_03200474 169436 STKLD1 C9orf96 SGK071 STKLD1 gene dto:DTO_03200475 102724428 150094 SIK1 SIK SNF1LK SIK1 gene dto:DTO_03200476 23235 SIK2 KIAA0781 QIK SNF1LK2 SIK2 gene dto:DTO_03200477 23387 SIK3 KIAA0999 QSK SIK3 gene dto:DTO_03200478 9748 SLK KIAA0204 STK2 SLK gene dto:DTO_03200479 This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013] 23049 SMG1 ATX KIAA0421 LIP SMG1 gene dto:DTO_03200480 SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009] 54861 SNRK KIAA0096 SNFRK SNRK gene dto:DTO_03200481 This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined. [provided by RefSeq, Mar 2010] 10290 SPEG APEG1 KIAA1297 SPEG gene dto:DTO_03200482 The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] 8877 SPHK1 SPHK SPK SPHK1 gene dto:DTO_03200483 This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] 56848 SPHK2 SPHK2 gene dto:DTO_03200484 This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] 6714 SRC SRC1 SRC gene dto:DTO_03200485 6725 SRMS C20orf148 SRMS gene dto:DTO_03200486 This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010] 6732 SRPK1 SRPK1 gene dto:DTO_03200487 6733 SRPK2 SRPK2 gene dto:DTO_03200488 This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] 26576 SRPK3 MSSK1 STK23 SRPK3 gene dto:DTO_03200489 This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008] 9263 STK17A DRAK1 STK17A gene dto:DTO_03200490 9262 STK17B DRAK2 STK17B gene dto:DTO_03200491 202374 STK32A YANK1 STK32A gene dto:DTO_03200492 55351 STK32B YANK2 STK32B gene dto:DTO_03200493 The protein encoded by this gene is a member of the serine/threonine protein kinase family. The specific function of this kinase is not known. [provided by RefSeq, Jul 2008] 282974 STK32C YANK3 STK32C gene dto:DTO_03200494 23012 STK38L KIAA0965 NDR2 STK38L gene dto:DTO_03200495 This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008] 6793 STK10 LOK STK10 gene dto:DTO_03200496 This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] 6794 STK11 LKB1 PJS STK11 gene dto:DTO_03200497 8576 STK16 MPSK1 PKL12 TSF1 STK16 gene dto:DTO_03200498 This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] 8428 STK24 MST3 STK3 STK24 gene dto:DTO_03200499 This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012] 10494 STK25 SOK1 YSK1 STK25 gene dto:DTO_03200500 This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] 56164 STK31 SGK396 STK31 gene dto:DTO_03200501 65975 STK33 STK33 gene dto:DTO_03200502 The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008] 140901 STK35 CLIK1 PDIK1 STK35L1 STK35 gene dto:DTO_03200503 This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] 27148 STK36 KIAA1278 STK36 gene dto:DTO_03200504 11329 STK38 NDR1 STK38 gene dto:DTO_03200505 This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008] 27347 STK39 SPAK STK39 gene dto:DTO_03200506 This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] 6788 STK3 KRS1 MST2 STK3 gene dto:DTO_03200507 83931 STK40 SGK495 SHIK STK40 gene dto:DTO_03200508 The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008] 6789 STK4 KRS2 MST1 STK4 gene dto:DTO_03200509 The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009] 92335 STRADA LYK5 STRAD STRADA gene dto:DTO_03200510 This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] 55437 STRADB ALS2CR2 ILPIP STRADB gene dto:DTO_03200511 Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008] 55359 STYK1 NOK STYK1 gene dto:DTO_03200512 The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] 10454 TAB1 MAP3K7IP1 TAB1 gene dto:DTO_03200513 Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013] 6872 TAF1 BA2R CCG1 CCGS TAF1 gene dto:DTO_03200514 57551 TAOK1 KIAA1361 MAP3K16 MARKK TAOK1 gene dto:DTO_03200515 This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] 9344 TAOK2 KIAA0881 MAP3K17 PSK TAOK2 gene dto:DTO_03200516 51347 TAOK3 DPK JIK KDS TAOK3 gene dto:DTO_03200517 This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] 93627 TBCK TBCKL TBCK gene dto:DTO_03200518 The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010] 29110 TBK1 NAK TBK1 gene dto:DTO_03200519 The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008] 7006 TEC PSCTK4 TEC gene dto:DTO_03200520 This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. [provided by RefSeq, Jul 2008] 7016 TESK1 TESK1 gene dto:DTO_03200521 This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. [provided by RefSeq, Jul 2008] 10420 TESK2 TESK2 gene dto:DTO_03200522 The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011] 56155 TEX14 SGK307 TEX14 gene dto:DTO_03200523 The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] 7046 TGFBR1 ALK5 SKR4 TGFBR1 gene dto:DTO_03200524 This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] 7048 TGFBR2 TGFBR2 gene dto:DTO_03200525 This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] 7075 TIE1 TIE TIE1 gene dto:DTO_03200526 This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014] 7010 TEK TIE2 VMCM VMCM1 TEK gene dto:DTO_03200527 This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012] 7273 TTN TTN gene dto:DTO_03200528 The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] 9874 TLK1 KIAA0137 TLK1 gene dto:DTO_03200529 This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] 11011 TLK2 TLK2 gene dto:DTO_03200530 This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012] 100526835 51086 TNNI3K CARK TNNI3K gene dto:DTO_03200531 Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008] 23043 TNIK KIAA0551 TNIK gene dto:DTO_03200532 The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] 8711 TNK1 TNK1 gene dto:DTO_03200533 This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] 55872 PBK TOPK PBK gene dto:DTO_03200534 This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] 27010 TPK1 TPK1 gene dto:DTO_03200535 10221 TRIB1 C8FW GIG2 TRB1 TRIB1 gene dto:DTO_03200536 This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] 28951 TRIB2 TRB2 TRIB2 gene dto:DTO_03200537 The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] 57761 TRIB3 C20orf97 NIPK SKIP3 TRIB3 gene dto:DTO_03200538 7204 TRIO TRIO gene dto:DTO_03200539 This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010] 140803 TRPM6 CHAK2 TRPM6 gene dto:DTO_03200540 TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008] 83942 TSSK1B SPOGA1 SPOGA4 STK22A TSSK1B gene dto:DTO_03200541 TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008] 23617 TSSK2 DGSG SPOGA2 STK22B TSSK2 gene dto:DTO_03200542 This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008] 81629 TSSK3 SPOGA3 STK22C TSSK3 gene dto:DTO_03200543 This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] 283629 TSSK4 C14orf20 STK22E TSSK5 TSSK4 gene dto:DTO_03200544 This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012] 83983 TSSK6 SSTK TSSK6 gene dto:DTO_03200545 84630 TTBK1 BDTK KIAA1855 TTBK1 gene dto:DTO_03200546 This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009] 146057 TTBK2 KIAA0847 TTBK2 gene dto:DTO_03200547 This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] 7272 TTK MPS1 MPS1L1 TTK gene dto:DTO_03200548 7294 TXK PTK4 RLK TXK gene dto:DTO_03200549 This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] 7297 TYK2 TYK2 gene dto:DTO_03200550 The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010] 7301 TYRO3 BYK DTK RSE TYRO3 gene dto:DTO_03200551 This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012] 83549 UCK1 URK1 UCK1 gene dto:DTO_03200552 This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010] 7371 UCK2 UMPK UCK2 gene dto:DTO_03200553 The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] 558 AXL UFO AXL gene dto:DTO_03200554 The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] 127933 UHMK1 KIS KIST UHMK1 gene dto:DTO_03200555 8408 ULK1 KIAA0722 ULK1 gene dto:DTO_03200556 This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008] 9706 ULK2 KIAA0623 ULK2 gene dto:DTO_03200557 25989 ULK3 ULK3 gene dto:DTO_03200558 54986 ULK4 ULK4 gene dto:DTO_03200559 This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009] 2321 FLT1 FLT FRT VEGFR1 FLT1 gene dto:DTO_03200560 Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009] 3791 KDR FLK1 VEGFR2 KDR gene dto:DTO_03200561 This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008] 2324 FLT4 VEGFR3 FLT4 gene dto:DTO_03200562 This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008] 7443 VRK1 VRK1 gene dto:DTO_03200563 This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014] 7444 VRK2 VRK2 gene dto:DTO_03200564 This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] 51231 VRK3 VRK3 gene dto:DTO_03200565 This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008] 7465 WEE1 WEE1 gene dto:DTO_03200566 494551 WEE2 WEE1B WEE2 gene dto:DTO_03200567 This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010] 65125 WNK1 HSN2 KDP KIAA0344 WNK1 gene dto:DTO_03200568 The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] 65268 WNK2 KIAA1760 PRKWNK2 SDCCAG43 WNK2 gene dto:DTO_03200569 This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] 65267 WNK3 KIAA1566 PRKWNK3 WNK3 gene dto:DTO_03200570 This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009] 65266 WNK4 PRKWNK4 WNK4 gene dto:DTO_03200571 This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] 7525 YES1 YES YES1 gene dto:DTO_03200572 This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] 7535 ZAP70 SRK ZAP70 gene dto:DTO_03200573 ETNK1 gene dto:DTO_03200574 ETNK2 gene dto:DTO_03200575 GALK2 gene dto:DTO_03200576 GALK1 gene dto:DTO_03200577 FUK gene dto:DTO_03200578 IDNK gene dto:DTO_03200579 CMPK2 gene dto:DTO_03200580 FGGY gene dto:DTO_03200581 FN3K gene dto:DTO_03200582 GK3P gene dto:DTO_03200583 GLYCTK gene dto:DTO_03200584 GK5 gene dto:DTO_03200585 GK gene dto:DTO_03200586 HKDC1 gene dto:DTO_03200587 HK3 gene dto:DTO_03200588 HK2 gene dto:DTO_03200589 ITPKC gene dto:DTO_03200590 IP6K2 gene dto:DTO_03200591 AK8 gene dto:DTO_03200592 IP6K1 gene dto:DTO_03200593 IP6K3 gene dto:DTO_03200594 NMRK1 gene dto:DTO_03200595 PANK4 gene dto:DTO_03200596 CMPK1 gene dto:DTO_03200597 AK6 gene dto:DTO_03200598 AK5 gene dto:DTO_03200599 CKB gene dto:DTO_03200600 CKMT1A gene dto:DTO_03200601 AK9 gene dto:DTO_03200602 AK4 gene dto:DTO_03200603 CKMT2 gene dto:DTO_03200604 FN3KRP gene dto:DTO_03200605 NADK gene dto:DTO_03200606 NADK2 gene dto:DTO_03200607 NAGK gene dto:DTO_03200608 NME1-NME2 gene dto:DTO_03200609 NME5 gene dto:DTO_03200610 NME2P1 gene dto:DTO_03200611 NME3 gene dto:DTO_03200612 NME6 gene dto:DTO_03200613 NME1 gene dto:DTO_03200614 NME4 gene dto:DTO_03200615 NMRK2 gene dto:DTO_03200616 PGK2 gene dto:DTO_03200617 PCK1 gene dto:DTO_03200618 PFKM gene dto:DTO_03200619 PFKP gene dto:DTO_03200620 PRPS1L1 gene dto:DTO_03200621 PRPS2 gene dto:DTO_03200622 PRPS1 gene dto:DTO_03200623 PSTK gene dto:DTO_03200624 SHPK gene dto:DTO_03200625 RBKS gene dto:DTO_03200626 TBCK gene dto:DTO_03200627 UCKL1 gene dto:DTO_03200628 XYLB gene dto:DTO_03300101 In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. https://en.wikipedia.org/wiki/Kinase Kinase dto:DTO_03300102 A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). https://en.wikipedia.org/wiki/Protein_kinase Protein kinase dto:DTO_03300103 A non-protein kinase is a kinase enzyme that modifies any non-protein substrates by chemically adding phosphate groups to them. Non-protein kinase dto:DTO_03300104 Other group dto:DTO_03300105 CAMK group dto:DTO_03300106 TK group dto:DTO_03300107 TKL group dto:DTO_03300108 Atypical group dto:DTO_03300109 AGC group dto:DTO_03300110 RGC group dto:DTO_03300111 CMGC group dto:DTO_03300112 CK1 group dto:DTO_03300113 STE group dto:DTO_03300115 NAK family dto:DTO_03300116 CAMKL family dto:DTO_03300117 ABL family dto:DTO_03300118 ACK family dto:DTO_03300119 STKR family dto:DTO_03300120 ABC1 family dto:DTO_03300121 AKT family dto:DTO_03300122 ALK family dto:DTO_03300123 Alpha family dto:DTO_03300124 RIPK family dto:DTO_03300125 RGC family dto:DTO_03300126 RAF family dto:DTO_03300127 GRK family dto:DTO_03300129 PIKK family dto:DTO_03300130 AUR family dto:DTO_03300131 PDHK family dto:DTO_03300132 SRC family dto:DTO_03300133 TEC family dto:DTO_03300134 BUB family dto:DTO_03300135 CAMK-UNIQUE family dto:DTO_03300136 CDK family dto:DTO_03300137 CDC7 family dto:DTO_03300138 CDKL family dto:DTO_03300139 RAD53 family dto:DTO_03300140 CLK family dto:DTO_03300141 PDGFR family dto:DTO_03300142 CK2 family dto:DTO_03300143 CASK family dto:DTO_03300144 CSK family dto:DTO_03300145 DMPK family dto:DTO_03300146 DAPK family dto:DTO_03300147 DCAMKL family dto:DTO_03300148 DDR family dto:DTO_03300149 SGK496 family dto:DTO_03300150 DYRK family dto:DTO_03300151 PEK family dto:DTO_03300152 EGFR family dto:DTO_03300153 EPH family dto:DTO_03300154 IRE family dto:DTO_03300155 FAK family dto:DTO_03300156 FAST family dto:DTO_03300157 FER family dto:DTO_03300158 FGFR family dto:DTO_03300159 GSK family dto:DTO_03300160 MAST family dto:DTO_03300161 HASPIN family dto:DTO_03300162 RCK family dto:DTO_03300163 INSR family dto:DTO_03300164 IKK family dto:DTO_03300165 MLK family dto:DTO_03300166 IRAK family dto:DTO_03300167 JAKA family dto:DTO_03300168 TRIO family dto:DTO_03300169 PKA family dto:DTO_03300170 CK1 family dto:DTO_03300171 CAMK1 family dto:DTO_03300172 CAMK2 family dto:DTO_03300173 PKG family dto:DTO_03300174 CAMKK family dto:DTO_03300175 PKC family dto:DTO_03300176 PKD family dto:DTO_03300177 PSK family dto:DTO_03300178 RSK family dto:DTO_03300179 RSKL family dto:DTO_03300180 SYK family dto:DTO_03300181 NDR family dto:DTO_03300182 LISK family dto:DTO_03300183 LMR family dto:DTO_03300184 LRRK family dto:DTO_03300185 STE-UNIQUE family dto:DTO_03300186 STE11 family dto:DTO_03300187 STE20 family dto:DTO_03300188 MAPKAPK family dto:DTO_03300189 AXL family dto:DTO_03300190 MET family dto:DTO_03300191 MAPK family dto:DTO_03300192 TKL-UNIQUE family dto:DTO_03300193 MOS family dto:DTO_03300194 STE7 family dto:DTO_03300195 MUSK family dto:DTO_03300196 MLCK family dto:DTO_03300197 NEK family dto:DTO_03300198 NRBP family dto:DTO_03300199 SCY1 family dto:DTO_03300200 TRK family dto:DTO_03300201 PAN3 family dto:DTO_03300202 NKF4 family dto:DTO_03300203 PDK1 family dto:DTO_03300204 NKF3 family dto:DTO_03300205 PHK family dto:DTO_03300206 VPS15 family dto:DTO_03300207 PIM family dto:DTO_03300208 NKF2 family dto:DTO_03300209 SGK493 family dto:DTO_03300210 PKN family dto:DTO_03300211 PLK family dto:DTO_03300212 WEE family dto:DTO_03300213 BUD32 family dto:DTO_03300214 CCK4 family dto:DTO_03300215 SLOB family dto:DTO_03300216 RET family dto:DTO_03300217 RIO family dto:DTO_03300218 Other-UNIQUE family dto:DTO_03300219 ROR family dto:DTO_03300220 SEV family dto:DTO_03300221 RYK family dto:DTO_03300222 NKF1 family dto:DTO_03300223 RSKR family dto:DTO_03300224 SGK family dto:DTO_03300225 SGK071 family dto:DTO_03300226 SRPK family dto:DTO_03300227 YANK family dto:DTO_03300228 ULK family dto:DTO_03300229 SGK495 family dto:DTO_03300230 TK-UNIQUE family dto:DTO_03300231 TAF1 family dto:DTO_03300232 TBCK family dto:DTO_03300233 NKF5 family dto:DTO_03300234 TIE family dto:DTO_03300235 TLK family dto:DTO_03300236 TOPK family dto:DTO_03300237 TRBL family dto:DTO_03300238 TSSK family dto:DTO_03300239 TTBK family dto:DTO_03300240 TTK family dto:DTO_03300241 KIS family dto:DTO_03300242 VEGFR family dto:DTO_03300243 VRK family dto:DTO_03300244 WNK family dto:DTO_03300245 AMPK subfamily dto:DTO_03300246 STKR Type 1 subfamily dto:DTO_03300247 ABC1-B subfamily dto:DTO_03300248 ABC1-C subfamily dto:DTO_03300249 ABC1-A subfamily dto:DTO_03300250 BARK subfamily dto:DTO_03300251 ATR subfamily dto:DTO_03300252 STKR Type 2 subfamily dto:DTO_03300253 BRSK subfamily dto:DTO_03300254 PITSLRE subfamily dto:DTO_03300255 CRK7 subfamily dto:DTO_03300256 TAIRE subfamily dto:DTO_03300257 CDK8 subfamily dto:DTO_03300258 CDK1 subfamily dto:DTO_03300259 CCRK subfamily dto:DTO_03300260 CDK4 subfamily dto:DTO_03300261 CDK5 subfamily dto:DTO_03300262 CDK7 subfamily dto:DTO_03300263 CDK9 subfamily dto:DTO_03300264 CHK1 subfamily dto:DTO_03300265 GEK subfamily dto:DTO_03300266 Dyrk1 subfamily dto:DTO_03300267 Dyrk2 subfamily dto:DTO_03300268 PEK subfamily dto:DTO_03300269 GCN2 subfamily dto:DTO_03300270 EEF2K subfamily dto:DTO_03300271 GRK subfamily dto:DTO_03300272 GSK subfamily dto:DTO_03300273 HIPK subfamily dto:DTO_03300274 ILK subfamily dto:DTO_03300275 Meta subfamily dto:DTO_03300276 PKC alpha subfamily dto:DTO_03300277 PKC delta subfamily dto:DTO_03300278 PKC eta subfamily dto:DTO_03300279 PKC iota subfamily dto:DTO_03300280 RSK subfamily dto:DTO_03300281 MSK subfamily dto:DTO_03300282 P70 subfamily dto:DTO_03300283 LIMK subfamily dto:DTO_03300284 MLK subfamily dto:DTO_03300285 LZK subfamily dto:DTO_03300286 TAK1 subfamily dto:DTO_03300287 KHS subfamily dto:DTO_03300288 MSN subfamily dto:DTO_03300289 MAPKAPK subfamily dto:DTO_03300290 MARK subfamily dto:DTO_03300291 MELK subfamily dto:DTO_03300292 ERK subfamily dto:DTO_03300293 JNK subfamily dto:DTO_03300294 P38 subfamily dto:DTO_03300295 Erk7 subfamily dto:DTO_03300296 MNK subfamily dto:DTO_03300297 YSK subfamily dto:DTO_03300298 NinaC subfamily dto:DTO_03300299 NIM1 subfamily dto:DTO_03300300 NMO subfamily dto:DTO_03300301 NuaK subfamily dto:DTO_03300302 FRAY subfamily dto:DTO_03300303 PAKA subfamily dto:DTO_03300304 PAKB subfamily dto:DTO_03300305 PASK subfamily dto:DTO_03300306 PDHK subfamily dto:DTO_03300307 PDK1 subfamily dto:DTO_03300308 PLK2 subfamily dto:DTO_03300309 DNAPK subfamily dto:DTO_03300311 RIO2 subfamily dto:DTO_03300313 ROCK subfamily dto:DTO_03300314 QIK subfamily dto:DTO_03300315 SLK subfamily dto:DTO_03300316 LKB subfamily dto:DTO_03300317 MST subfamily> dto:DTO_03300318 TAO subfamily dto:DTO_03300319 TESK subfamily dto:DTO_03300320 HH498 subfamily dto:DTO_03300321 ChaK subfamily dto:DTO_03300322 A Nucleoside kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleoside substrate. Nucleoside kinase dto:DTO_03300323 A lipid kinase is a kinase enzyme that catalyzes the phosphorylation of a lipid substrate. Lipid kinase dto:DTO_03300324 Other small molecule kinase is a kinase enzyme that catalyzes the phosphorylation of a small molecule substrate other than a carbohydrate, nucleoside, nucleotide, lipid, etc. Other small molecule kinase dto:DTO_03300325 A carbohydrate kinase is a kinase enzyme that catalyzes the phosphorylation of a carbohydrate substrate. Carbohydrate kinase dto:DTO_03300326 A Nucleotide kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleotide substrate. Nucleotide kinase dto:DTO_03390001 A protein containing a catalytically inactive kinase domain. https://en.wiktionary.org/wiki/pseudokinase Pseudokinase dto:DTO_03390989 Eukaryotic two domain clade "E" sub-subfamily dto:DTO_03390993 TBC domain-containing protein kinase-like protein dto:DTO_03391001 AK1 subfamily dto:DTO_03391002 ATP-dependent PFK group I subfamily dto:DTO_03391003 Type III PI4K subfamily dto:DTO_03391004 AK2 subfamily dto:DTO_03391005 Type II PI4K subfamily dto:DTO_03391006 AK3 subfamily dto:DTO_03391007 Mevalonate kinase subfamily dto:DTO_03391008 DCK/DGK family dto:DTO_03391009 PI3/PI4 kinase family dto:DTO_03391010 Phosphoinositide 3-kinase (PI3K) family dto:DTO_03391011 Pyridoxine kinase family dto:DTO_03391012 Type I phosphatidylinositol-4-phosphate 5-kinase family dto:DTO_03391013 Phosphoglycerate kinase family dto:DTO_03391014 Adenylate kinase family dto:DTO_03391015 Thymidine kinase family dto:DTO_03391016 Phosphofructokinase type A (PFKA) family dto:DTO_03391017 Hexokinase family dto:DTO_03391018 Thymidylate kinase family dto:DTO_03391019 Inositol phosphokinase (IPK) family dto:DTO_03391020 ITPK1 family dto:DTO_03391021 FGGY kinase family dto:DTO_03391022 Phosphoenolpyruvate carboxykinase [GTP] family dto:DTO_03391023 Thiamine pyrophosphokinase family dto:DTO_03391024 Uridine kinase family dto:DTO_03391025 Diacylglycerol kinase family dto:DTO_03391026 GHMP kinase family dto:DTO_03391027 ATP:guanido phosphotransferase family dto:DTO_03391028 Type II pantothenate kinase family dto:DTO_03391029 Choline/ethanolamine kinase family dto:DTO_03391030 Guanylate kinase family dto:DTO_03391031 PI3K p85 subunit family dto:DTO_03391032 Carbohydrate kinase PfkB family dto:DTO_03391033 CDK10 subfamily dto:DTO_03391034 HUNK subfamily dto:DTO_03391035 FRAP subfamily dto:DTO_03391036 RIO3 subfamily dto:DTO_03391037 RIO1 subfamily dto:DTO_03391038 SNRK subfamily dto:DTO_03391039 Phosphorylase b kinase regulatory chain family dto:DTO_03391040 Ephrin family dto:DTO_03391041 A probable kinase protein that is not yet classified into either protein kinase or non-protein kinase. Unclassified protein dto:DTO_03400101 In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. https://en.wikipedia.org/wiki/Kinase Kinase gene dto:DTO_03400102 A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). https://en.wikipedia.org/wiki/Protein_kinase Protein kinase gene dto:DTO_03400103 A non-protein kinase is a kinase enzyme that modifies any non-protein substrates by chemically adding phosphate groups to them. Non-protein kinase gene dto:DTO_03400104 Other group gene dto:DTO_03400105 CAMK group gene dto:DTO_03400106 TK group gene dto:DTO_03400107 TKL group gene dto:DTO_03400108 Atypical group gene dto:DTO_03400109 AGC group gene dto:DTO_03400110 RGC group gene dto:DTO_03400111 CMGC group gene dto:DTO_03400112 CK1 group gene dto:DTO_03400113 STE group gene dto:DTO_03400115 NAK family gene dto:DTO_03400116 CAMKL family gene dto:DTO_03400117 ABL family gene dto:DTO_03400118 ACK family gene dto:DTO_03400119 STKR family gene dto:DTO_03400120 ABC1 family gene dto:DTO_03400121 AKT family gene dto:DTO_03400122 ALK family gene dto:DTO_03400123 Alpha family gene dto:DTO_03400124 RIPK family gene dto:DTO_03400125 RGC family gene dto:DTO_03400126 RAF family gene dto:DTO_03400127 GRK family gene dto:DTO_03400129 PIKK family gene dto:DTO_03400130 AUR family gene dto:DTO_03400131 PDHK family gene dto:DTO_03400132 SRC family gene dto:DTO_03400133 TEC family gene dto:DTO_03400134 BUB family gene dto:DTO_03400135 CAMK-UNIQUE family gene dto:DTO_03400136 CDK family gene dto:DTO_03400137 CDC7 family gene dto:DTO_03400138 CDKL family gene dto:DTO_03400139 RAD53 family gene dto:DTO_03400140 CLK family gene dto:DTO_03400141 PDGFR family gene dto:DTO_03400142 CK2 family gene dto:DTO_03400143 CASK family gene dto:DTO_03400144 CSK family gene dto:DTO_03400145 DMPK family gene dto:DTO_03400146 DAPK family gene dto:DTO_03400147 DCAMKL family gene dto:DTO_03400148 DDR family gene dto:DTO_03400149 SGK496 family gene dto:DTO_03400150 DYRK family gene dto:DTO_03400151 PEK family gene dto:DTO_03400152 EGFR family gene dto:DTO_03400153 EPH family gene dto:DTO_03400154 IRE family gene dto:DTO_03400155 FAK family gene dto:DTO_03400156 FAST family gene dto:DTO_03400157 FER family gene dto:DTO_03400158 FGFR family gene dto:DTO_03400159 GSK family gene dto:DTO_03400160 MAST family gene dto:DTO_03400161 HASPIN family gene dto:DTO_03400162 RCK family gene dto:DTO_03400163 INSR family gene dto:DTO_03400164 IKK family gene dto:DTO_03400165 MLK family gene dto:DTO_03400166 IRAK family gene dto:DTO_03400167 JAKA family gene dto:DTO_03400168 TRIO family gene dto:DTO_03400169 PKA family gene dto:DTO_03400170 CK1 family gene dto:DTO_03400171 CAMK1 family gene dto:DTO_03400172 CAMK2 family gene dto:DTO_03400173 PKG family gene dto:DTO_03400174 CAMKK family gene dto:DTO_03400175 PKC family gene dto:DTO_03400176 PKD family gene dto:DTO_03400177 PSK family gene dto:DTO_03400178 RSK family gene dto:DTO_03400179 RSKL family gene dto:DTO_03400180 SYK family gene dto:DTO_03400181 NDR family gene dto:DTO_03400182 LISK family gene dto:DTO_03400183 LMR family gene dto:DTO_03400184 LRRK family gene dto:DTO_03400185 STE-UNIQUE family gene dto:DTO_03400186 STE11 family gene dto:DTO_03400187 STE20 family gene dto:DTO_03400188 MAPKAPK family gene dto:DTO_03400189 AXL family gene dto:DTO_03400190 MET family gene dto:DTO_03400191 MAPK family gene dto:DTO_03400192 TKL-UNIQUE family gene dto:DTO_03400193 MOS family gene dto:DTO_03400194 STE7 family gene dto:DTO_03400195 MUSK family gene dto:DTO_03400196 MLCK family gene dto:DTO_03400197 NEK family gene dto:DTO_03400198 NRBP family gene dto:DTO_03400199 SCY1 family gene dto:DTO_03400200 TRK family gene dto:DTO_03400201 PAN3 family gene dto:DTO_03400202 NKF4 family gene dto:DTO_03400203 PDK1 family gene dto:DTO_03400204 NKF3 family gene dto:DTO_03400205 PHK family gene dto:DTO_03400206 VPS15 family gene dto:DTO_03400207 PIM family gene dto:DTO_03400208 NKF2 family gene dto:DTO_03400209 SGK493 family gene dto:DTO_03400210 PKN family gene dto:DTO_03400211 PLK family gene dto:DTO_03400212 WEE family gene dto:DTO_03400213 BUD32 family gene dto:DTO_03400214 CCK4 family gene dto:DTO_03400215 SLOB family gene dto:DTO_03400216 RET family gene dto:DTO_03400217 RIO family gene dto:DTO_03400218 Other-UNIQUE family gene dto:DTO_03400219 ROR family gene dto:DTO_03400220 SEV family gene dto:DTO_03400221 RYK family gene dto:DTO_03400222 NKF1 family gene dto:DTO_03400223 RSKR family gene dto:DTO_03400224 SGK family gene dto:DTO_03400225 SGK071 family gene dto:DTO_03400226 SRPK family gene dto:DTO_03400227 YANK family gene dto:DTO_03400228 ULK family gene dto:DTO_03400229 SGK495 family gene dto:DTO_03400230 TK-UNIQUE family gene dto:DTO_03400231 TAF1 family gene dto:DTO_03400232 TBCK family gene dto:DTO_03400233 NKF5 family gene dto:DTO_03400234 TIE family gene dto:DTO_03400235 TLK family gene dto:DTO_03400236 TOPK family gene dto:DTO_03400237 TRBL family gene dto:DTO_03400238 TSSK family gene dto:DTO_03400239 TTBK family gene dto:DTO_03400240 TTK family gene dto:DTO_03400241 KIS family gene dto:DTO_03400242 VEGFR family gene dto:DTO_03400243 VRK family gene dto:DTO_03400244 WNK family gene dto:DTO_03400245 AMPK subfamily gene dto:DTO_03400246 STKR Type 1 subfamily gene dto:DTO_03400247 ABC1-B subfamily gene dto:DTO_03400248 ABC1-C subfamily gene dto:DTO_03400249 ABC1-A subfamily gene dto:DTO_03400250 BARK subfamily gene dto:DTO_03400251 ATR subfamily gene dto:DTO_03400252 STKR Type 2 subfamily gene dto:DTO_03400253 BRSK subfamily gene dto:DTO_03400254 PITSLRE subfamily gene dto:DTO_03400255 CRK7 subfamily gene dto:DTO_03400256 TAIRE subfamily gene dto:DTO_03400257 CDK8 subfamily gene dto:DTO_03400258 CDK1 subfamily gene dto:DTO_03400259 CCRK subfamily gene dto:DTO_03400260 CDK4 subfamily gene dto:DTO_03400261 CDK5 subfamily gene dto:DTO_03400262 CDK7 subfamily gene dto:DTO_03400263 CDK9 subfamily gene dto:DTO_03400264 CHK1 subfamily gene dto:DTO_03400265 GEK subfamily gene dto:DTO_03400266 Dyrk1 subfamily gene dto:DTO_03400267 Dyrk2 subfamily gene dto:DTO_03400268 PEK subfamily gene dto:DTO_03400269 GCN2 subfamily gene dto:DTO_03400270 EEF2K subfamily gene dto:DTO_03400271 GRK subfamily gene dto:DTO_03400272 GSK subfamily gene dto:DTO_03400273 HIPK subfamily gene dto:DTO_03400274 ILK subfamily gene dto:DTO_03400275 Meta subfamily gene dto:DTO_03400276 PKC alpha subfamily gene dto:DTO_03400277 PKC delta subfamily gene dto:DTO_03400278 PKC eta subfamily gene dto:DTO_03400279 PKC iota subfamily gene dto:DTO_03400280 RSK subfamily gene dto:DTO_03400281 MSK subfamily gene dto:DTO_03400282 P70 subfamily gene dto:DTO_03400283 LIMK subfamily gene dto:DTO_03400284 MLK subfamily gene dto:DTO_03400285 LZK subfamily gene dto:DTO_03400286 TAK1 subfamily gene dto:DTO_03400287 KHS subfamily gene dto:DTO_03400288 MSN subfamily gene dto:DTO_03400289 MAPKAPK subfamily gene dto:DTO_03400290 MARK subfamily gene dto:DTO_03400291 MELK subfamily gene dto:DTO_03400292 ERK subfamily gene dto:DTO_03400293 JNK subfamily gene dto:DTO_03400294 P38 subfamily gene dto:DTO_03400295 Erk7 subfamily gene dto:DTO_03400296 MNK subfamily gene dto:DTO_03400297 YSK subfamily gene dto:DTO_03400298 NinaC subfamily gene dto:DTO_03400299 NIM1 subfamily gene dto:DTO_03400300 NMO subfamily gene dto:DTO_03400301 NuaK subfamily gene dto:DTO_03400302 FRAY subfamily gene dto:DTO_03400303 PAKA subfamily gene dto:DTO_03400304 PAKB subfamily gene dto:DTO_03400305 PASK subfamily gene dto:DTO_03400306 PDHK subfamily gene dto:DTO_03400307 PDK1 subfamily gene dto:DTO_03400308 PLK2 subfamily gene dto:DTO_03400309 DNAPK subfamily gene dto:DTO_03400311 RIO2 subfamily gene dto:DTO_03400313 ROCK subfamily gene dto:DTO_03400314 QIK subfamily gene dto:DTO_03400315 SLK subfamily gene dto:DTO_03400316 LKB subfamily gene dto:DTO_03400317 MST subfamily> gene dto:DTO_03400318 TAO subfamily gene dto:DTO_03400319 TESK subfamily gene dto:DTO_03400320 HH498 subfamily gene dto:DTO_03400321 ChaK subfamily gene dto:DTO_03400322 A Nucleoside kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleoside substrate. Nucleoside kinase gene dto:DTO_03400323 A lipid kinase is a kinase enzyme that catalyzes the phosphorylation of a lipid substrate. Lipid kinase gene dto:DTO_03400324 Other small molecule kinase is a kinase enzyme that catalyzes the phosphorylation of a small molecule substrate other than a carbohydrate, nucleoside, nucleotide, lipid, etc. Other small molecule kinase gene dto:DTO_03400325 A carbohydrate kinase is a kinase enzyme that catalyzes the phosphorylation of a carbohydrate substrate. Carbohydrate kinase gene dto:DTO_03400326 A Nucleotide kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleotide substrate. Nucleotide kinase gene dto:DTO_03490993 TBCK gene dto:DTO_03491001 AK1 subfamily gene dto:DTO_03491002 ATP-dependent PFK group I subfamily gene dto:DTO_03491003 Type III PI4K subfamily gene dto:DTO_03491004 AK2 subfamily gene dto:DTO_03491005 Type II PI4K subfamily gene dto:DTO_03491006 AK3 subfamily gene dto:DTO_03491007 Mevalonate kinase subfamily gene dto:DTO_03491008 DCK/DGK family gene dto:DTO_03491009 PI3/PI4 kinase family gene dto:DTO_03491010 Phosphoinositide 3-kinase (PI3K) family gene dto:DTO_03491011 Pyridoxine kinase family gene dto:DTO_03491012 Type I phosphatidylinositol-4-phosphate 5-kinase family gene dto:DTO_03491013 Phosphoglycerate kinase family gene dto:DTO_03491014 Adenylate kinase family gene dto:DTO_03491015 Thymidine kinase family gene dto:DTO_03491016 Phosphofructokinase type A (PFKA) family gene dto:DTO_03491017 Hexokinase family gene dto:DTO_03491018 Thymidylate kinase family gene dto:DTO_03491019 Inositol phosphokinase (IPK) family gene dto:DTO_03491020 ITPK1 family gene dto:DTO_03491021 FGGY kinase family gene dto:DTO_03491022 Phosphoenolpyruvate carboxykinase [GTP] family gene dto:DTO_03491023 Thiamine pyrophosphokinase family gene dto:DTO_03491024 Uridine kinase family gene dto:DTO_03491025 Diacylglycerol kinase family gene dto:DTO_03491026 GHMP kinase family gene dto:DTO_03491027 ATP:guanido phosphotransferase family gene dto:DTO_03491028 Type II pantothenate kinase family gene dto:DTO_03491029 Choline/ethanolamine kinase family gene dto:DTO_03491030 Guanylate kinase family gene dto:DTO_03491031 PI3K p85 subunit family gene dto:DTO_03491032 Carbohydrate kinase PfkB family gene dto:DTO_03491033 CDK10 subfamily gene dto:DTO_03491034 HUNK subfamily gene dto:DTO_03491035 FRAP subfamily gene dto:DTO_03491036 RIO3 subfamily gene dto:DTO_03491037 RIO1 subfamily gene dto:DTO_03491038 SNRK subfamily gene dto:DTO_03491039 Phosphorylase b kinase regulatory chain family gene dto:DTO_03491040 Ephrin family gene dto:DTO_03491041 A probable kinase protein that is not yet classified into either protein kinase or non-protein kinase. Unclassified protein gene dto:DTO_03491042 RIOK3 RIOK3 gene dto:DTO_03491043 RIOK1 RIOK1 gene dto:DTO_03491044 PKLR PKLR gene dto:DTO_03491045 PANK3 PANK3 gene dto:DTO_03491046 PANK2 PANK2 gene dto:DTO_03491047 PFKFB1 PFKFB1 gene dto:DTO_03491048 PFKFB2 PFKFB2 gene dto:DTO_03491049 PFKFB3 PFKFB3 gene dto:DTO_0349989 Eukaryotic two domain clade "E" sub-subfamily gene dto:DTO_05390001 Putative infectious disease target dto:DTO_05390002 Putative mental health drug target dto:DTO_05390003 Putative metabolic drug target dto:DTO_09000001 CXCL12 dto:DTO_09000002 CCL19 dto:DTO_09000003 Adrenocorticotropic hormone (ACTH) dto:DTO_09000004 Angiotensin A dto:DTO_09000005 Apelin-17 dto:DTO_09000007 C5a dto:DTO_09000008 C5a des-Arg dto:DTO_09000010 CCL27 dto:DTO_09000011 CCL13 dto:DTO_09000012 CCL11 dto:DTO_09000013 CCL17 dto:DTO_09000014 Beta-defensin 4A dto:DTO_09000015 CCL1 dto:DTO_09000016 CCL25 dto:DTO_09000017 Chemerin dto:DTO_09000019 CX3CL1 dto:DTO_09000020 Cytokine domain of tyrosyl tRNA synthetase dto:DTO_09000021 CXCL1 dto:DTO_09000022 CXCL13 dto:DTO_09000023 CXCL16 dto:DTO_09000024 Prosaptide dto:DTO_09000026 Spinorphin dto:DTO_09000027 PrP106-126 dto:DTO_09000028 Annexin I-(2-26) dto:DTO_09000029 Wnt-3a dto:DTO_09000030 [125I][Tyr26]galanin (human) dto:DTO_09000032 Gastric inhibitory polypeptide dto:DTO_09000033 GnRH I dto:DTO_09000034 17 beta-estradiol dto:DTO_09000037 CCL5 dto:DTO_09000038 LPA dto:DTO_09000039 L-lactic acid dto:DTO_09000040 CCL16 dto:DTO_09000043 Farnesyl monophosphate dto:DTO_09000044 HCG dto:DTO_09000045 Alpha-MSH dto:DTO_09000046 C3a dto:DTO_09000048 Hemokinin 1 dto:DTO_09000049 Gastrin releasing peptide(14-27) (human) dto:DTO_09000050 Neuromedin S-33 dto:DTO_09000051 Des-Br-neuropeptide B-23 dto:DTO_09000053 Large neuromedin N dto:DTO_09000057 Alpha-ketoglutaric acid dto:DTO_09000058 Arginine vasotocin dto:DTO_09000060 PGE1 dto:DTO_09000061 Prokineticin-1 dto:DTO_09000062 PrRP-20 dto:DTO_09000063 PAF dto:DTO_09000065 PTHrP-(1-34) (human) dto:DTO_09000066 QRFP dto:DTO_09000067 H3 relaxin dto:DTO_09000068 H1 relaxin dto:DTO_09000069 Cortistatin-14 dto:DTO_09000071 GHRH dto:DTO_09000072 XCL2 dto:DTO_09000074 5-HT-moduline dto:DTO_09000075 CXCL11 dto:DTO_09000076 (±)-adrenaline dto:DTO_09000079 [des-Arg10]kallidin dto:DTO_09000081 Ribosomal protein S19 dto:DTO_09000084 CCL28 dto:DTO_09000085 CCL8 dto:DTO_09000086 CCL22 dto:DTO_09000087 CCL20 dto:DTO_09000088 CCL21 dto:DTO_09000092 CXCL2 dto:DTO_09000093 SDF-1 beta dto:DTO_09000096 Annexin I dto:DTO_09000097 F2L dto:DTO_09000098 Wnt-4 dto:DTO_09000100 Glucagon-like peptide 1-(7-36) amide dto:DTO_09000101 Glucagon-like peptide 2-(3-33) dto:DTO_09000102 N-palmitoylethanolamine dto:DTO_09000112 L-serine-O-phosphate dto:DTO_09000119 Agouti-related protein dto:DTO_09000120 Neuromedin U-25 dto:DTO_09000121 Des-Br-neuropeptide B-29 dto:DTO_09000124 Neuropeptide Y-(3-36) dto:DTO_09000126 Large neurotensin dto:DTO_09000128 Dynorphin A-(1-13) dto:DTO_09000130 5-oxo-20-HETE dto:DTO_09000133 Prokineticin-2 dto:DTO_09000134 PrRP-31 dto:DTO_09000136 QRFP26 dto:DTO_09000137 H3 relaxin (B chain) dto:DTO_09000138 INSL5 dto:DTO_09000139 H2 relaxin dto:DTO_09000141 CST-17 dto:DTO_09000144 Urotensin-related peptide dto:DTO_09000146 XCL1 dto:DTO_09000151 CCL14 dto:DTO_09000152 CCL2 dto:DTO_09000153 CCL15 dto:DTO_09000156 CXCL6 dto:DTO_09000157 CXCL3 dto:DTO_09000158 Aspirin triggered lipoxin A4 dto:DTO_09000160 Wnt-5a dto:DTO_09000162 Glucagon-like peptide 1-(7-37) dto:DTO_09000164 SEA dto:DTO_09000174 Dynorphin A-(1-8) dto:DTO_09000175 5-oxo-C20:3 dto:DTO_09000177 Prokineticin-2beta dto:DTO_09000179 SRIF-14 dto:DTO_09000181 [Pyr1]apelin-13 dto:DTO_09000183 CCL7 dto:DTO_09000185 CXCL8 dto:DTO_09000186 CXCL5 dto:DTO_09000187 Aspirin-triggered resolvin D1 dto:DTO_09000188 Desulfated cholecystokinin-8 dto:DTO_09000192 Kisspeptin-54 dto:DTO_09000198 PYY-(3-36) dto:DTO_09000203 SRIF-28 dto:DTO_09000204 PHM dto:DTO_09000207 CCL23 dto:DTO_09000208 CCL24 dto:DTO_09000209 CXCL10 dto:DTO_09000215 5-oxo-ODE dto:DTO_09000219 CCL26 dto:DTO_09000220 CXCL7 dto:DTO_09000229 CXCL9 dto:DTO_09000231 5-oxo-12-HETE dto:DTO_09000232 Serum amyloid A dto:DTO_0900052 [Leu31,Pro34]PYY (human) dto:DTO_09000566 N-oleoylethanolamide dto:DTO_09000576 5-oxo-15-HETE dto:DTO_09000614 PTH dto:DTO_09000617 TSH dto:DTO_09000618 Cathepsin G dto:DTO_0900099 CCK-4 dto:DTO_61000000 A structurally conserved protein domain containing the catalytic function of the kinase. https://en.wikipedia.org/wiki/Protein_kinase_domain kinase domain dto:DTO_61000002 AP2 associated kinase 1; AAK1; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; FLJ42882; FLJ45252; KIAA1048; MGC138170; MGC164568; MGC164570 200001 AAK1 kinase domain dto:DTO_61000003 ABL1 kinase domain dto:DTO_61000004 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200003 ABL1(E255K) kinase domain dto:DTO_61000005 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200004 ABL1(E255K)-phosphorylated kinase domain dto:DTO_61000006 ABL1(F317I) kinase domain dto:DTO_61000007 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200005, 200006 ABL1(F317I)-nonphosphorylated kinase domain dto:DTO_61000008 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200007 ABL1(F317I)-phosphorylated kinase domain dto:DTO_61000009 ABL1(F317L) kinase domain dto:DTO_61000010 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200008, 200009 ABL1(F317L)-nonphosphorylated kinase domain dto:DTO_61000011 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200010 ABL1(F317L)-phosphorylated kinase domain dto:DTO_61000012 ABL1(H396P) kinase domain dto:DTO_61000013 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200011, 200012 ABL1(H396P)-nonphosphorylated kinase domain dto:DTO_61000014 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200013 ABL1(H396P)-phosphorylated kinase domain dto:DTO_61000015 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200014 ABL1(M351T) kinase domain dto:DTO_61000016 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200015 ABL1(M351T)-phosphorylated kinase domain dto:DTO_61000017 ABL1(Q252H) kinase domain dto:DTO_61000018 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200016, 200017 ABL1(Q252H)-nonphosphorylated kinase domain dto:DTO_61000019 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200018 ABL1(Q252H)-phosphorylated kinase domain dto:DTO_61000020 ABL1(T315I) kinase domain dto:DTO_61000021 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200019, 200020 ABL1(T315I)-nonphosphorylated kinase domain dto:DTO_61000022 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200021 ABL1(T315I)-phosphorylated kinase domain dto:DTO_61000023 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200022 ABL1(Y253F) kinase domain dto:DTO_61000024 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200023 ABL1(Y253F)-phosphorylated kinase domain dto:DTO_61000025 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200002, 200024 ABL1-nonphosphorylated kinase domain dto:DTO_61000026 C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl 200025 ABL1-phosphorylated kinase domain dto:DTO_61000027 V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene); ABL2; ABLL; ARG; FLJ22224; FLJ31718; FLJ41441 200026 ABL2 kinase domain dto:DTO_61000028 Activin A receptor, type I; ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI 200027 ACVR1 kinase domain dto:DTO_61000029 Activin A receptor, type IB; ACTRIB; ACVR1B; ACVRLK4; ALK4; SKR2 200028 ACVR1B kinase domain dto:DTO_61000030 Activin A receptor, type IIA; ActR2; ACTRII; ACVR2; ACVR2A 200029 ACVR2A kinase domain dto:DTO_61000031 Activin A receptor, type IIB; ActR2B; ACTRIIB; ActR-IIB; ACVR2B; MGC116908 200030 ACVR2B kinase domain dto:DTO_61000032 Activin A receptor type II-like 1; ACVRL1; ACVRLK1; ALK1; ALK-1; HHT; HHT2; ORW2; SKR3; TSR-I 200031 ACVRL1 kinase domain dto:DTO_61000033 Chaperone, ABC1 activity of bc1 complex homolog (S. pombe); ADCK3; ARCA2; CABC1; COQ8; MGC4849; SCAR9 200032 ADCK3 kinase domain dto:DTO_61000034 AarF domain containing kinase 4; ADCK4; FLJ12229 200033 ADCK4 kinase domain dto:DTO_61000035 V-akt murine thymoma viral oncogene homolog 1; AKT; AKT1; Akt1/PKBa; MGC99656; PKB; PKBa; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA 200034 AKT1 kinase domain dto:DTO_61000036 V-akt murine thymoma viral oncogene homolog 2; AKT2; Akt2/PKBb; PKBb; PKBBETA; PRKBB; RAC-BETA 200035 AKT2 kinase domain dto:DTO_61000037 V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); AKT3; Akt3/PKBg; DKFZp434N0250; PKBg; PKB-GAMMA; PRKBG; RAC-gamma; RAC-PK-gamma; STK-2 200036 AKT3 kinase domain dto:DTO_61000038 Anaplastic lymphoma receptor tyrosine kinase; ALK; CD246; NBLST3; TFG/ALK 200037 ALK kinase domain dto:DTO_61000039 Anaplastic lymphoma receptor tyrosine kinase; ALK; CD246; NBLST3; TFG/ALK 200479 ALK(C1156Y) kinase domain dto:DTO_61000040 Anaplastic lymphoma receptor tyrosine kinase; ALK; CD246; NBLST3; TFG/ALK 200480 ALK(L1196M) kinase domain dto:DTO_61000041 Protein kinase, AMP-activated, alpha 2 catalytic subunit; AMPK; AMPKa1; AMPK-alpha1; MGC33776; MGC57364; PRKAA1 200038 AMPK-alpha1 kinase domain dto:DTO_61000042 Protein kinase, AMP-activated, alpha 2 catalytic subunit; AMPK; AMPK2; AMPKa2; AMPK-alpha2; PRKAA; PRKAA2 200039 AMPK-alpha2 kinase domain dto:DTO_61000043 Ankyrin repeat and kinase domain containing 1; ANKK1; PKK2; SgK288 200040 ANKK1 kinase domain dto:DTO_61000044 Aurora kinase A; AIK; AIRK1; ARK1; Aur2; AURA; AurA/Aur2; AURKA; AURORA2; Aurora-A; Ayk1; BTAK; IAK; IAK1; MGC34538; STK15; STK6; STK7 200044 AURKA kinase domain dto:DTO_61000045 Aurora kinase B; AIK2; AIM1; AIM-1; ARK2; Aur1; AurB; AurB/Aur1; AURKB; aurkb-sv1; aurkb-sv2; IPL1; STK12; STK5 200045 AURKB kinase domain dto:DTO_61000046 Aurora kinase C; AIE2; AIK3; ARK3; Aur3; AurC; AurC/Aur3; AURKC; aurora-C; STK13 200046 AURKC kinase domain dto:DTO_61000047 AXL receptor tyrosine kinase; AXL; JTK11; UFO 200047 AXL kinase domain dto:DTO_61000048 BMP2 inducible kinase; BIKE; BMP2K; DKFZp434K0614; DKFZp434P0116; HRIHFB2017 200048 BIKE kinase domain dto:DTO_61000049 Tyrosine-protein kinase BLK; B lymphoid tyrosine kinase; BLK; MGC10442 200049 BLK kinase domain dto:DTO_61000050 Bone morphogenetic protein receptor, type IA; 10q23del; ACVRLK3; ALK3; BMPR1A; CD292; SKR5 200050 BMPR1A kinase domain dto:DTO_61000051 Bone morphogenetic protein receptor, type IB; ALK6; ALK-6; BMPR1B; CDw293 200051 BMPR1B kinase domain dto:DTO_61000052 Bone morphogenetic protein receptor, type II (serine/threonine kinase); BMPR2; BMPR3; BMPR-II; BMR2; BRK-3; FLJ41585; FLJ76945; PPH1; T-ALK 200052 BMPR2 kinase domain dto:DTO_61000053 BMX non-receptor tyrosine kinase; BMX; ETK; Etk/BMX; PSCTK2; PSCTK3 200053 BMX kinase domain dto:DTO_61000054 Serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B1; BRAF1; RAFB1 200054 BRAF kinase domain dto:DTO_61000055 V-raf murine sarcoma viral oncogene homolog B1; BRAF; BRAF1; B-RAF1; FLJ95109; MGC126806; MGC138284; RAFB1 200055 BRAF(V600E) kinase domain dto:DTO_61000056 BR serine/threonine kinase 1; BRSK1; FLJ43009; KIAA1811 200057 BRSK1 kinase domain dto:DTO_61000057 BR serine/threonine kinase 2; BRSK2; C11orf7; FLJ41362; PEN11B; SAD1; STK29 200058 BRSK2 kinase domain dto:DTO_61000058 Tyrosine-protein kinase BTK; agammaglobulinemia tyrosine kinase; AGMX1; ATK; BPK 200059 BTK kinase domain dto:DTO_61000059 Budding uninhibited by benzimidazoles 1 homolog (yeast); BUB1A; BUB1L; hBUB1 200470 BUB1 kinase domain dto:DTO_61000060 Calcium/calmodulin-dependent protein kinase I; CAMK1; CaMK1a; CAMKI; MGC120317; MGC120318 200060 CAMK1 kinase domain dto:DTO_61000061 Calcium/calmodulin-dependent protein kinase ID; CaM-K1; CAMK1D; CaMKID; CKLiK 200061 CAMK1D kinase domain dto:DTO_61000062 Calcium/calmodulin-dependent protein kinase IG; CAMK1G; CLICKIII; dJ272L16.1; VWS1 200062 CAMK1G kinase domain dto:DTO_61000063 Calcium/calmodulin-dependent protein kinase II alpha; CAMK2A; CAMKA; KIAA0968 200063 CAMK2A kinase domain dto:DTO_61000064 Calcium/calmodulin-dependent protein kinase II beta; CAM2; CAMK2; CAMK2B; CAMKB; MGC29528 200064 CAMK2B kinase domain dto:DTO_61000065 Calcium/calmodulin-dependent protein kinase II gamma; CAMK; CAMK2G; CAMKG; CAMK-II; FLJ16043; MGC26678 200066 CAMK2G kinase domain dto:DTO_61000066 Calcium/calmodulin-dependent protein kinase kinase 2, beta; CAMKK; CAMKK2; CAMKKB; KIAA0787; MGC15254 200069 CAMKK2 kinase domain dto:DTO_61000067 Calcium/calmodulin-dependent serine protein kinase (MAGUK family); CAGH39; CAMGUK; CASK; CMG; FGS4; FLJ22219; FLJ31914; LIN2; MICPCH; TNRC8 200070 CASK kinase domain dto:DTO_61000068 Cyclin-dependent kinase 11B; CDC2L1; CDC2L2; CDK11; CDK11B; CDK11-p110; CDK11-p46; CDK11-p58; CLK-1; FLJ59152; p58; p58CDC2L1; p58CLK-1; PITSLRE; PK58 200071 CDC2L1 kinase domain dto:DTO_61000069 Cyclin-dependent kinase 11A; CDC2L2; CDC2L3; CDK11A; CDK11-p110; CDK11-p46; CDK11-p58; MGC131975; p58GTA; PITSLRE 200072 CDC2L2 kinase domain dto:DTO_61000070 Cyclin-dependent kinase 13; CDC2L; CDC2L5; CDK13; CHED; FLJ35215; KIAA1791 200073 CDC2L5 kinase domain dto:DTO_61000071 Cyclin-dependent kinase 19; bA346C16.3; CDC2L6; CDK11; CDK19; KIAA1028 200074 CDK11 kinase domain dto:DTO_61000072 Cyclin-dependent kinase 14; serine/threonine-protein kinase PFTAIRE-1; PFTK1 200318 CDK14 kinase domain dto:DTO_61000073 Cyclin-Dependent Kinase 15; serine/threonine-protein kinase ALS2CR7; PFTAIRE2; PFTK2 200317 CDK15 kinase domain dto:DTO_61000074 Cyclin-dependent kinase 16; Cell division protein kinase 16; Serine/threonine-protein kinase PCTAIRE-1; FLJ16665; PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1 200309 CDK16 kinase domain dto:DTO_61000075 Cyclin-dependent kinase 2; p33 protein kinase 200075 CDK2 kinase domain dto:DTO_61000076 Cyclin-dependent kinase 3; CDK3 200076 CDK3 kinase domain dto:DTO_61000077 Cyclin-dependent kinase 4; cell division protein kinase 4 200077 CDK4-cyclinD1 kinase domain dto:DTO_61000078 Cyclin-dependent kinase 4; cell division protein kinase 4 200078 CDK4-cyclinD3 kinase domain dto:DTO_61000079 Cyclin-dependent kinase 5; cell division protein kinase 5; PSSALRE 200079 CDK5 kinase domain dto:DTO_61000080 Cyclin-dependent kinase 7; cell division protein kinase 7; CAK1; CDK7; CDKN7; MO15; p39MO15; STK1 200080 CDK7 kinase domain dto:DTO_61000081 Cyclin-dependent kinase 8; cell division protein kinase 8; CDK8; K35; MGC126074; MGC126075 200081 CDK8 kinase domain dto:DTO_61000082 Cyclin-dependent kinase 9; cell division protein kinase 9; C-2k; CDC2L4; CDK9; CTK1; PITALRE; TAK 200082 CDK9 kinase domain dto:DTO_61000083 Cyclin-dependent kinase-like 1 (CDC2-related kinase); CDKL1; KKIALRE; P42 200083 CDKL1 kinase domain dto:DTO_61000084 Cyclin-dependent kinase-like 2 (CDC2-related kinase); CDKL2; KKIAMRE; P56 200084 CDKL2 kinase domain dto:DTO_61000085 Cyclin-dependent kinase-like 3; CDKL3; NKIAMRE 200085 CDKL3 kinase domain dto:DTO_61000086 Cyclin-dependent kinase-like 5; CDKL5; ISSX; STK9 200086 CDKL5 kinase domain dto:DTO_61000087 CHK1 checkpoint homolog (S. pombe); CHEK1; CHK1 200087 CHEK1 kinase domain dto:DTO_61000088 Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog 200088 CHK2 kinase domain dto:DTO_61000089 Citron (rho-interacting, serine/threonine kinase 21); CIT; CRIK; KIAA0949; STK21 200089 CIT kinase domain dto:DTO_61000090 CDC-like kinase 1; CLK; CLK/STY; CLK1; STY 200090 CLK1 kinase domain dto:DTO_61000091 Dual specificity protein kinase CLK2; CDC-like kinase 2; CLK2; hCLK2; MGC61500 200091 CLK2 kinase domain dto:DTO_61000092 Dual specificity protein kinase CLK3; CDC-like kinase 3; CLK3; FLJ22858; PHCLK3; PHCLK3/152 200092 CLK3 kinase domain dto:DTO_61000093 CDC-like kinase 4; CLK4; DKFZp686A20267 200093 CLK4 kinase domain dto:DTO_61000094 Colony stimulating factor 1 receptor; CD115; C-FMS; CSF1R; CSF-1R; CSF-1-R; CSFR; FIM2; FIM-2; FMS; Fms/CSFR 200094 CSF1R kinase domain dto:DTO_61000095 Colony stimulating factor 1 receptor; CD115; C-FMS; CSF1R; CSF-1R; CSF-1-R; CSFR; FIM2; FIM-2; FMS; Fms/CSFR 200471 CSF1R-autoinhibited kinase domain dto:DTO_61000096 C-src tyrosine kinase; CSK; MGC117393 200095 CSK kinase domain dto:DTO_61000097 Casein kinase 1, alpha 1; CK1; CK1a; CSNK1A1; HLCDGP1; PRO2975 200096 CSNK1A1 kinase domain dto:DTO_61000098 Casein kinase 1, alpha 1-like; CK1; CK1a2; CSNK1A1L; MGC33182 200097 CSNK1A1L kinase domain dto:DTO_61000099 Casein kinase 1, delta; CK1d; CSNK1D; HCKID 200098 CSNK1D kinase domain dto:DTO_61000100 Casein kinase 1, epsilon; CK1e; CSNK1E; HCKIE; MGC10398 200099 CSNK1E kinase domain dto:DTO_61000101 Casein kinase 1, gamma 3; CK1g3; CSNK1G3 200102 CSNK1G3 kinase domain dto:DTO_61000102 Casein kinase 2, alpha 1 polypeptide; CK2A1; CKII; CSNK2A1 200103 CSNK2A1 kinase domain dto:DTO_61000103 Casein kinase 2, alpha prime polypeptide; CK2A2; CSNK2A1; CSNK2A2; FLJ43934 200104 CSNK2A2 kinase domain dto:DTO_61000104 Megakaryocyte-associated tyrosine kinase; CHK; CTK; DKFZp434N1212; HHYLTK; HYL; HYLTK; Lsk; MATK; MGC1708; MGC2101 200105 CTK kinase domain dto:DTO_61000105 Death-associated protein kinase 1; DAPK; DAPK1; DKFZp781I035 200106 DAPK1 kinase domain dto:DTO_61000106 Death-associated protein kinase 2; DAPK2; DRP1; DRP-1; MGC119312 200107 DAPK2 kinase domain dto:DTO_61000107 Death-associated protein kinase 3; DAPK3; FLJ36473; ZIP; ZIPK 200108 DAPK3 kinase domain dto:DTO_61000108 Doublecortin-like kinase 2; CL2; CLICK2; CLICK-II; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2; DCLK2; DKFZp761l032; MGC45428 200110 DCAMKL2 kinase domain dto:DTO_61000109 Doublecortin-like kinase 3; CLR; DCAMKL3; DCDC3C; DCK3; DCLK3; KIAA1765 200111 DCAMKL3 kinase domain dto:DTO_61000110 Serine/threonine-protein kinase DCLK1; CL1; CLICK1; DCAMKL1; DCDC3A; DCLK; DCLK1; KIAA0369 200109 DCLK1 kinase domain dto:DTO_61000111 Discoidin domain receptor tyrosine kinase 1; CAK; CD167; DDR; DDR1; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE 200112 DDR1 kinase domain dto:DTO_61000112 Discoidin domain receptor tyrosine kinase 2; DDR2; MIG20a; NTRKR3; TKT; TYRO10 200113 DDR2 kinase domain dto:DTO_61000113 Myotonin-protein kinase; Dystrophia myotonica-protein kinase; DM; DM1; DM1PK; DMK; MDPK; MT-PK 200115 DMPK kinase domain dto:DTO_61000114 CDC42 binding protein kinase gamma (DMPK-like); CDC42BPG; DMPK2; HSMDPKIN; KAPPA-200; MRCKgamma 200116 DMPK2 kinase domain dto:DTO_61000115 Serine/threonine kinase 17a; DRAK1; STK17A 200117 DRAK1 kinase domain dto:DTO_61000116 Serine/threonine kinase 17b; DRAK2; STK17B 200118 DRAK2 kinase domain dto:DTO_61000117 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK; DYRK1; DYRK1A; HP86; MNB; MNBH 200119 DYRK1A kinase domain dto:DTO_61000118 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; DYRK1B; MIRK 200120 DYRK1B kinase domain dto:DTO_61000119 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; FLJ21217; FLJ21365 200121 DYRK2 kinase domain dto:DTO_61000120 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200122 EGFR kinase domain dto:DTO_61000121 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200123 EGFR(E746-A750del) kinase domain dto:DTO_61000122 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200124 EGFR(G719C) kinase domain dto:DTO_61000123 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200125 EGFR(G719S) kinase domain dto:DTO_61000124 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200126 EGFR(L747-E749del, A750P) kinase domain dto:DTO_61000125 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200127 EGFR(L747-S752del, P753S) kinase domain dto:DTO_61000126 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200128 EGFR(L747-T751del,Sins) kinase domain dto:DTO_61000127 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200129 EGFR(L858R) kinase domain dto:DTO_61000128 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200130 EGFR(L858R,T790M) kinase domain dto:DTO_61000129 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200131 EGFR(L861Q) kinase domain dto:DTO_61000130 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200132 EGFR(S752-I759del) kinase domain dto:DTO_61000131 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61 200133 EGFR(T790M) kinase domain dto:DTO_61000132 Eukaryotic translation initiation factor 2-alpha kinase 1; EIF2AK1; HCR; HRI; KIAA1369 200134 EIF2AK1 kinase domain dto:DTO_61000133 EPH receptor A1; EPH; EPHA1; EPHT; EPHT1; MGC163163 200135 EPHA1 kinase domain dto:DTO_61000134 EPH receptor A2; ARCC2; ECK; EPHA2 200136 EPHA2 kinase domain dto:DTO_61000135 EPH receptor A3; EK4; EPHA3; ETK; ETK1; HEK; HEK4; TYRO4 200137 EPHA3 kinase domain dto:DTO_61000136 EPH receptor A4; EPHA4; HEK8; SEK; TYRO1 200138 EPHA4 kinase domain dto:DTO_61000137 EPH receptor A5; CEK7; EHK1; EPHA5; HEK7; TYRO4 200139 EPHA5 kinase domain dto:DTO_61000138 EPH receptor A6; DKFZp434C1418; EPA6; EPHA6; FLJ35246; PRO57066 200140 EPHA6 kinase domain dto:DTO_61000139 EPH receptor A7; EHK3; EPHA7; HEK11 200141 EPHA7 kinase domain dto:DTO_61000140 EPH receptor A8; EEK; EK3; EPHA8; HEK3; KIAA1459 200142 EPHA8 kinase domain dto:DTO_61000141 Ephrin type-B receptor 1; ELK; EPHB1; EPHT2; FLJ37986; Hek6; NET 200143 EPHB1 kinase domain dto:DTO_61000142 Ephrin type-B receptor 2; CAPB; DRT; EK5; EPHB2; EPHT3; ERK; Hek5; MGC87492; PCBC; Tyro5 200144 EPHB2 kinase domain dto:DTO_61000143 Ephrin type-B receptor 3; EPHB3; ETK2; HEK2; TYRO6 200145 EPHB3 kinase domain dto:DTO_61000144 Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11 200146 EPHB4 kinase domain dto:DTO_61000145 EPH receptor B6; EPHB6; HEP; MGC129910; MGC129911 200147 EPHB6 kinase domain dto:DTO_61000146 Receptor tyrosine-protein kinase erbB-2; CD340; ERBB2; HER2; HER-2; HER-2/neu; MLN 19; NEU; NGL; TKR1 200148 ERBB2 kinase domain dto:DTO_61000147 Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3 200149 ERBB3 kinase domain dto:DTO_61000148 Receptor tyrosine-protein kinase erbB-4; HER4; MGC138404; p180erbB4 200150 ERBB4 kinase domain dto:DTO_61000149 Mitogen-activated protein kinase 6; DKFZp686F03189; ERK3; HsT17250; MAPK6; p97MAPK; PRKM6 200153 ERK3 kinase domain dto:DTO_61000150 Mitogen-activated protein kinase 4; ERK3; Erk4; MAPK4; p63MAPK; PRKM4 200154 ERK4 kinase domain dto:DTO_61000151 Mitogen-activated protein kinase 7; BMK1; ERK4; ERK5; MAPK7; PRKM7 200155 ERK5 kinase domain dto:DTO_61000152 Mitogen-activated protein kinase 15; ERK7; ERK8; MAPK15 200156 ERK8 kinase domain dto:DTO_61000153 Endoplasmic reticulum to nucleus signaling 1; ERN1; FLJ30999; hIRE1p; IRE1; IRE1a; IRE1P; MGC163277; MGC163279 200157 ERN1 kinase domain dto:DTO_61000154 PTK2 protein tyrosine kinase 2; FADK; FAK; FAK1; FRNK; pp125FAK; PTK2 200158 FAK1 kinase domain dto:DTO_61000155 Protein-tyrosine kinase 2-beta; CADTK; CAKB; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK 200367 FAK2 kinase domain dto:DTO_61000156 Fer (fps/fes related) tyrosine kinase; FER; TYK3 200159 FER kinase domain dto:DTO_61000157 Feline sarcoma oncogene; FES; FPS 200160 FES kinase domain dto:DTO_61000158 Fibroblast growth factor receptor 1; BFGFR; CD331; CEK; FGFBR; FGFR1; FLG; FLJ99988; FLT2; HBGFR; KAL2; N-SAM; OGD 200161 FGFR1 kinase domain dto:DTO_61000159 Fibroblast growth factor receptor 2; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; FGFR2; FLJ98662; JWS; KGFR; K-SAM; TK14; TK25 200162 FGFR2 kinase domain dto:DTO_61000160 Fibroblast growth factor receptor 3; ACH; CD333; CEK2; FGFR3; HSFGFR3EX; JTK4 200163 FGFR3 kinase domain dto:DTO_61000161 Fibroblast growth factor receptor 3; ACH; CD333; CEK2; FGFR3; HSFGFR3EX; JTK4 200164 FGFR3(G697C) kinase domain dto:DTO_61000162 Fibroblast growth factor receptor 4; CD334; FGFR4; JTK2; MGC20292; TKF 200165 FGFR4 kinase domain dto:DTO_61000163 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; c-fgr; c-src2; FGR; FLJ43153; MGC75096; p55c-fgr; p55-Fgr; p58c-fgr; SRC2 200166 FGR kinase domain dto:DTO_61000164 Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1 200168 FLT3 kinase domain dto:DTO_61000165 Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1 200169 FLT3(D835H) kinase domain dto:DTO_61000166 Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1 200170 FLT3(D835Y) kinase domain dto:DTO_61000167 Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1 200171 FLT3(ITD) kinase domain dto:DTO_61000168 Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1 200172 FLT3(K663Q) kinase domain dto:DTO_61000169 Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1 200173 FLT3(N841I) kinase domain dto:DTO_61000170 Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1 200174 FLT3(R834Q) kinase domain dto:DTO_61000171 Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1 200472 FLT3-autoinhibited kinase domain dto:DTO_61000172 Fms-related tyrosine kinase 4; FLT4; FLT41; LMPH1A; PCL; VEGFR3 200175 FLT4 kinase domain dto:DTO_61000173 Tyrosine-protein kinase FRK; Fyn-related kinase; FRK; GTK; PTK5; RAK 200176 FRK kinase domain dto:DTO_61000174 FYN oncogene related to SRC, FGR, YES; FYN; MGC45350; SLK; SYN 200177 FYN kinase domain dto:DTO_61000175 Cyclin G associated kinase; FLJ16629; FLJ40395; GAK; MGC99654 200178 GAK kinase domain dto:DTO_61000176 Eukaryotic translation initiation factor 2 alpha kinase 4; EIF2AK4; GCN2; KIAA1338 200179 GCN2(Kin.Dom.2,S808G) kinase domain dto:DTO_61000177 G protein-coupled receptor kinase 1; GPRK1; GRK1; RHODK; RHODK/GRK1; RHOK; RK 200180 GRK1 kinase domain dto:DTO_61000178 G protein-coupled receptor kinase 4; GPRK2L; GPRK4; GRK4; GRK4a; IT11 200181 GRK4 kinase domain dto:DTO_61000179 G protein-coupled receptor kinase 7; GPRK7; GRK7 200182 GRK7 kinase domain dto:DTO_61000180 Glycogen synthase kinase 3 alpha; DKFZp686D0638; GSK3A; GSK3alpha; GSK3-alpha 200183 GSK3A kinase domain dto:DTO_61000181 Glycogen synthase kinase 3 beta; GSK3B; GSK3beta; GSK3-beta 200184 GSK3B kinase domain dto:DTO_61000182 Serine/threonine-protein kinase haspin; germ cell associated 2 (haspin); GSG2; HASPIN 200473 HASP kinase domain dto:DTO_61000183 Hemopoietic cell kinase; HCK; JTK9 200185 HCK kinase domain dto:DTO_61000184 Homeodomain interacting protein kinase 1; HIPK1; KIAA0630; MGC26642; MGC33446; MGC33548; Myak; Nbak2 200186 HIPK1 kinase domain dto:DTO_61000185 Homeodomain interacting protein kinase 2; DKFZp686K02111; FLJ23711; HIPK2; PRO0593 200187 HIPK2 kinase domain dto:DTO_61000186 Homeodomain interacting protein kinase 3; DYRK6; FIST3; HIPK3; PKY; YAK1 200188 HIPK3 kinase domain dto:DTO_61000187 Homeodomain interacting protein kinase 4; FLJ32818; HIPK4 200189 HIPK4 kinase domain dto:DTO_61000188 Hormonally up-regulated Neu-associated kinase; HUNK 200191 HUNK kinase domain dto:DTO_61000189 Intestinal cell (MAK-like) kinase; ECO; ICK; KIAA0936; LCK2; MGC46090; MRK 200192 ICK kinase domain dto:DTO_61000190 Insulin-like growth factor 1 receptor; CD221; IGF1R; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216 200193 IGF1R kinase domain dto:DTO_61000191 Inhibitor of nuclear factor kappa-B kinase subunit alpha 200194 IKKA kinase domain dto:DTO_61000192 Inhibitor of nuclear factor kappa-B kinase subunit beta 200195 IKKB kinase domain dto:DTO_61000193 Inhibitor of nuclear factor kappa-B kinase subunit epsilon 200196 IKKE kinase domain dto:DTO_61000194 Insulin receptor; CD220; HHF5; INSR; IR 200197 INSR kinase domain dto:DTO_61000195 Insulin receptor-related receptor; INSRR; IRR 200198 INSRR kinase domain dto:DTO_61000196 Interleukin-1 receptor-associated kinase 1 200199 IRAK1 kinase domain dto:DTO_61000197 Interleukin-1 receptor-associated kinase 3; ASRT5; FLJ13601; IRAK3; IRAKM 200200 IRAK3 kinase domain dto:DTO_61000198 Interleukin-1 receptor-associated kinase 4; IPD1; NY-REN-64; REN64 200201 IRAK4 kinase domain dto:DTO_61000199 IL2-inducible T-cell kinase; EMT; ITK; LYK; MGC126257; MGC126258; PSCTK2 200202 ITK kinase domain dto:DTO_61000200 Janus kinase 1; JAK1; JAK1~b; JAK1A; JAK1B; JAK1-pseudokinase; JTK3 200203, 200205 JAK1(Kin.Dom.1) kinase domain dto:DTO_61000201 Janus kinase 1; JAK1; JAK1~b; JAK1A; JAK1B; JAK1-pseudokinase; JTK3 200204, 200206 JAK1(Kin.Dom.2) kinase domain dto:DTO_61000202 Janus kinase 2; JAK2; JAK2-catalytic; JTK10 200207 JAK2(JH1domain-catalytic) kinase domain dto:DTO_61000203 Janus kinase 2; JAK2; JAK2-catalytic; JTK10 200208 JAK2(Kin.Dom.2) kinase domain dto:DTO_61000204 Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; L-JAK 200209 JAK3(JH1domain-catalytic) kinase domain dto:DTO_61000205 Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; L-JAK 200210 JAK3(Kin.Dom.2) kinase domain dto:DTO_61000206 Mitogen-activated protein kinase 8; JNK; JNK1; JNK1A2; JNK21B1/2; MAPK8; PRKM8; SAPK1 200211 JNK1 kinase domain dto:DTO_61000207 Mitogen-activated protein kinase 10; FLJ12099; FLJ33785; JNK3; JNK3A; MAPK10; MGC50974; p493F12; p54bSAPK; PRKM10 200213 JNK3 kinase domain dto:DTO_61000208 Casein kinase I isoform gamma-1; CK1g1; CSNK1G1 200100 KC1G1 kinase domain dto:DTO_61000209 Casein kinase I isoform gamma-2; Casein kinase 1, gamma 2; CK1g2; CSNK1G2 200101 KC1G2 kinase domain dto:DTO_61000210 Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit delta; CAMK2D; CAMKD; DKFZp686G23119; DKFZp686I2288; MGC44911 200065 KCC2D kinase domain dto:DTO_61000211 Calcium/calmodulin-dependent protein kinase type IV; CAMK4; CaMK-GR; MGC36771 200067 KCC4 kinase domain dto:DTO_61000212 Protein kinase, cGMP-dependent, type I; CGKI; cGKI-alpha; cGKI-BETA; DKFZp686K042; FLJ36117; MGC71944; PGK; PKG; PKG1; PRKG1; PRKG1B; PRKGR1B 200362 KGP1 kinase domain dto:DTO_61000213 Protein kinase, cGMP-dependent, type II; cGKII; PKG2; PRKG2; PRKGR2 200363 KGP2 kinase domain dto:DTO_61000214 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR 200214 KIT kinase domain dto:DTO_61000215 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR 200215 KIT(A829P) kinase domain dto:DTO_61000216 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR 200216 KIT(D816H) kinase domain dto:DTO_61000217 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR 200217 KIT(D816V) kinase domain dto:DTO_61000218 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR 200218 KIT(L576P) kinase domain dto:DTO_61000219 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR 200219 KIT(V559D) kinase domain dto:DTO_61000220 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR 200220 KIT(V559D,T670I) kinase domain dto:DTO_61000221 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR 200221 KIT(V559D,V654A) kinase domain dto:DTO_61000222 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR 200474 KIT-autoinhibited kinase domain dto:DTO_61000223 Calcium/calmodulin-dependent protein kinase kinase 1, CaM-kinase IV kinase; CAMKK1; CAMKKA; DKFZp761M0423; MGC34095 200068 KKCC1 kinase domain dto:DTO_61000224 Protein kinase C, delta; May1; MGC49908; nPKC-delta; PKCD; PRKCD 200354 KPCD kinase domain dto:DTO_61000225 Protein kinase D1; PKCM; PKC-MU; PKD; PKD1; PRKCM; PRKD1 200359 KPCD1 kinase domain dto:DTO_61000226 Protein kinase D2; HSPC187; PKD2; PRKD2 200360 KPCD2 kinase domain dto:DTO_61000227 Protein kinase D3; EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN; PRKD3 200361 KPCD3 kinase domain dto:DTO_61000228 Protein kinase C, epsilon; MGC125656; MGC125657; nPKC-epsilon; PKCE; PRKCE 200355 KPCE kinase domain dto:DTO_61000229 Protein kinase C, iota; DXS1179E; MGC26534; nPKC-iota; PKCI; PRKCI 200357 KPCI kinase domain dto:DTO_61000230 Protein kinase C, eta; MGC26269; MGC5363; nPKC-eta; PKCL; PKC-L; PRKCH; PRKCL 200356 KPCL kinase domain dto:DTO_61000231 Protein kinase C theta type; MGC126514; MGC141919; nPKC-theta; PKCt; PRKCQ; PRKCT 200358 KPCT kinase domain dto:DTO_61000232 LATS, large tumor suppressor, homolog 1 (Drosophila); LATS1; WARTS; wts 200222 LATS1 kinase domain dto:DTO_61000233 LATS, large tumor suppressor, homolog 2 (Drosophila); FLJ13161; KPM; LATS2 200223 LATS2 kinase domain dto:DTO_61000234 Lymphocyte-specific protein tyrosine kinase; LCK; LSK; p56lck; pp58lck; YT16 200224 LCK kinase domain dto:DTO_61000235 LIM domain kinase 1; LIMK 200225 LIMK1 kinase domain dto:DTO_61000236 LIM domain kinase 2; LIMK2 200226 LIMK2 kinase domain dto:DTO_61000237 Serine/threonine kinase 11; LKB1; PJS; STK11 200227 LKB1 kinase domain dto:DTO_61000238 Serine/threonine-protein kinase 10 200228 LOK kinase domain dto:DTO_61000239 Leucine-rich repeat serine/threonine-protein kinase 2; AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2 200229 LRRK2 kinase domain dto:DTO_61000240 Leucine-rich repeat serine/threonine-protein kinase 2; AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2 200230 LRRK2(G2019S) kinase domain dto:DTO_61000241 Leukocyte receptor tyrosine kinase; LTK; TYK1 200231 LTK kinase domain dto:DTO_61000242 V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; FLJ26625; JTK8; LYN 200232 LYN kinase domain dto:DTO_61000243 Mitogen-activated protein kinase kinase kinase 12; Dual leucine zipper bearing kinase; DLK; MAP3K12; MEKK12; MUK; ZPK; ZPKP1 200114 M3K12 kinase domain dto:DTO_61000244 Mitogen-activated protein kinase kinase kinase 13; LZK; MAP3K13; MEKK13; MGC133196 200233 M3K13 kinase domain dto:DTO_61000245 Mitogen-activated protein kinase kinase kinase 2; MAP3K2; MEKK2; MEKK2/MAP3K2; MEKK2B 200237 M3K2 kinase domain dto:DTO_61000246 Mitogen-activated protein kinase kinase kinase 5; ASK; ASK/MAP3K5; ASK1; MAP3K5; MAPKKK5; MEKK5 200042 M3K5 kinase domain dto:DTO_61000247 Mitogen-activated protein kinase kinase kinase 6; ASK2; MAP3K6; MAPKKK6; MEKK6; MEKK6/MAP3K6; MGC125653; MGC20114 200043 M3K6 kinase domain dto:DTO_61000248 Mitogen-activated protein kinase kinase kinase kinase 1; HPK1; MAP4K1 200190 M4K1 kinase domain dto:DTO_61000249 Mitogen-activated protein kinase kinase kinase kinase 3; GLK; KHS2; MAP4K3; MAPKKKK3; MEKKK3; RAB8IPL1 200241 M4K3 kinase domain dto:DTO_61000250 Male germ cell-associated kinase; dJ417M14.2; MAK 200234 MAK kinase domain dto:DTO_61000251 Mitogen-activated protein kinase kinase kinase 1; MAP3K1; MAPKKK1; MEKK; MEKK1; MEKK1/MAP3K1 200235 MAP3K1 kinase domain dto:DTO_61000252 Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; NIK 201107 MAP3K14 kinase domain dto:DTO_61000253 Mitogen-activated protein kinase kinase kinase 15; bA723P2.3; FLJ16518; MAP3K15; MAP3K7 200236 MAP3K15 kinase domain dto:DTO_61000254 Mitogen-activated protein kinase kinase kinase 3; MAP3K3; MAPKKK3; MEKK3; MEKK3/MAP3K3 200238 MAP3K3 kinase domain dto:DTO_61000255 Mitogen-activated protein kinase kinase kinase 4; FLJ42439; KIAA0213; MAP3K4; MAPKKK4; MEKK4; MTK1; PRO0412 200239 MAP3K4 kinase domain dto:DTO_61000256 Mitogen-activated protein kinase kinase kinase kinase 2; BL44; GCK; MAP4K2; RAB8IP 200240 MAP4K2 kinase domain dto:DTO_61000257 Mitogen-activated protein kinase kinase kinase kinase 4; FLH21957; FLJ10410; FLJ20373; FLJ90111; HGK; HGK/ZC1; KIAA0687; MAP4K4; NIK; ZC1 200242 MAP4K4 kinase domain dto:DTO_61000258 Mitogen-activated protein kinase kinase kinase kinase 5; GCKR; KHS; KHS1; MAP4K5; MAPKKKK5 200243 MAP4K5 kinase domain dto:DTO_61000259 Mitogen-activated protein kinase-activated protein kinase 2; MAPKAPK2; MK2 200244 MAPKAPK2 kinase domain dto:DTO_61000260 Mitogen-activated protein kinase-activated protein kinase 5; MAPKAPK5; PRAK 200245 MAPKAPK5 kinase domain dto:DTO_61000261 MAP/microtubule affinity-regulating kinase 1; KIAA1477; MARK; MARK1; MGC126512; MGC126513 200246 MARK1 kinase domain dto:DTO_61000262 Serine/threonine-protein kinase MARK2; MAP/microtubule affinity-regulating kinase 2; EMK1; EMK-1; MGC99619; PAR-1; Par1b 200247 MARK2 kinase domain dto:DTO_61000263 MAP/microtubule affinity-regulating kinase 3; CTAK1; KP78; MARK3; PAR1A 200248 MARK3 kinase domain dto:DTO_61000264 MAP/microtubule affinity-regulating kinase 4; FLJ90097; KIAA1860; MARKL1; Nbla00650 200249 MARK4 kinase domain dto:DTO_61000265 Microtubule associated serine/threonine kinase 1; KIAA0973; MAST1; SAST; SAST170 200250 MAST1 kinase domain dto:DTO_61000266 Maternal embryonic leucine zipper kinase; HPK38; KIAA0175 200257 MELK kinase domain dto:DTO_61000267 C-mer proto-oncogene tyrosine kinase; c-mer; MER; MERTK; MGC133349; RP38 200258 MERTK kinase domain dto:DTO_61000268 Hepatocyte growth factor receptor; AUTS9; c-Met; HGFR; MET; RCCP2 200259 MET kinase domain dto:DTO_61000269 Hepatocyte growth factor receptor; AUTS9; c-Met; HGFR; MET; RCCP2 200260 MET(M1250T) kinase domain dto:DTO_61000270 Hepatocyte growth factor receptor; AUTS9; c-Met; HGFR; MET; RCCP2 200261 MET(Y1235D) kinase domain dto:DTO_61000271 Misshapen-like kinase 1 (zebrafish); B55; hMINK; hMINKbeta; MAP4K6; MGC21111; MINK; MINK/ZC3; MINK1; YSK2; ZC3 200262 MINK kinase domain dto:DTO_61000272 Mitogen-activated protein kinase 1; ERK; ERK2; ERT1; MAPK1; MAPK2; p38; p40; p41; p41mapk; P42MAPK; PRKM1; PRKM2 200152 MK01 kinase domain dto:DTO_61000273 Mitogen-activated protein kinase 3; ERK1; HS44KDAP; HUMKER1A; MAPK3; MGC20180; P44ERK1; P44MAPK; PRKM3 200151 MK03 kinase domain dto:DTO_61000274 Mitogen-activated protein kinase 9; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; JNK-55; MAPK9; p54a; p54aSAPK; PRKM9; SAPK 200212 MK09 kinase domain dto:DTO_61000275 Mitogen-activated protein kinase 11; MAPK11; p38-2; p38b; p38Beta; p38-beta; P38BETA2; PRKM11; SAPK2; SAPK2B 200299 MK11 kinase domain dto:DTO_61000276 Mitogen-activated protein kinase 12; ERK3; ERK6; MAPK12; p38g; P38GAMMA; p38-gamma; PRKM12; SAPK3; SAPK-3 200301 MK12 kinase domain dto:DTO_61000277 Mitogen-activated protein kinase 13; MAPK13; MGC99536; p38d; p38delta; p38-delta; PRKM13; SAPK4 200300 MK13 kinase domain dto:DTO_61000278 Mitogen-activated protein kinase 14; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; Mxi2; p38; p38a; p38ALPHA; p38-alpha; PRKM14; PRKM15; RK; SAPK2A 200298 MK14 kinase domain dto:DTO_61000279 MAP kinase interacting serine/threonine kinase 1; MKNK1; MNK1 200264 MKNK1 kinase domain dto:DTO_61000280 MAP kinase interacting serine/threonine kinase 2; GPRK7; MKNK2; MNK2 200265 MKNK2 kinase domain dto:DTO_61000281 Myosin light chain kinase 3; caMLCK; MGC126319; MGC126320; MLCK; MLCK2; MYLK3 200266 MLCK kinase domain dto:DTO_61000282 Mitogen-activated protein kinase kinase kinase 9; MAP3K9; MEKK9; MLK1; PRKE1 200267 MLK1 kinase domain dto:DTO_61000283 Mitogen-activated protein kinase kinase kinase 10; MAP3K10; MEKK10; MLK2; MST 200268 MLK2 kinase domain dto:DTO_61000284 Mitogen-activated protein kinase kinase kinase 11; MAP3K11; MEKK11; MGC17114; MLK3; MLK-3; PTK1; SPRK 200269 MLK3 kinase domain dto:DTO_61000285 Mitogen-activated protein kinase kinase kinase MLT; sterile alpha motif and leucine zipper containing kinase AZK; AZK; MLK7; mlklak; MLT; MLTK; MRK; pk; ZAK 200468 MLTK kinase domain dto:DTO_61000286 Dual specificity mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1; MAP2K1; MAPKK1; MEK1; MEK1/MAP2K1; MKK1; PRKMK1 200251 MP2K1 kinase domain dto:DTO_61000287 Dual specificity mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; FLJ26075; MAP2K2; MAPKK2; MEK2; MEK2/MAP2K2; MKK2; PRKMK2 200252 MP2K2 kinase domain dto:DTO_61000288 Dual specificity mitogen-activated protein kinase kinase 3; mitogen-activated protein kinase kinase 3; MAP2K3; MAPKK3; MEK3; MKK3; MKK3/MAP2K3; PRKMK3 200253 MP2K3 kinase domain dto:DTO_61000289 Dual specificity mitogen-activated protein kinase kinase 4; mitogen-activated protein kinase kinase 4; JNKK; JNKK1; MAP2K4; MAPKK4; MEK4; MKK4; PRKMK4; SEK1; SEK1/MAP2K4; SERK1 200254 MP2K4 kinase domain dto:DTO_61000290 Dual specificity mitogen-activated protein kinase kinase 5; mitogen-activated protein kinase kinase 5; HsT17454; MAP2K5; MAPKK5; MEK5; PRKMK5 200255 MP2K5 kinase domain dto:DTO_61000291 Dual specificity mitogen-activated protein kinase kinase 6; mitogen-activated protein kinase kinase 6; MAP2K6; MAPKK6; MEK6; MKK6; MKK6/MAP2K6; PRKMK6; SAPKK3 200256 MP2K6 kinase domain dto:DTO_61000292 Dual specificity mitogen-activated protein kinase kinase 7 200263 MP2K7 kinase domain dto:DTO_61000293 CDC42 binding protein kinase alpha (DMPK-like); CDC42BPA; DKFZp686L1738; DKFZp686P1738; FLJ23347; KIAA0451; MRCK; MRCKA; PK428 200270 MRCKA kinase domain dto:DTO_61000294 CDC42 binding protein kinase beta (DMPK-like); CDC42BPB; KIAA1124; MRCKB 200271 MRCKB kinase domain dto:DTO_61000295 Serine/threonine kinase 4; DKFZp686A2068; KRS2; MST1; STK4; YSK3 200272 MST1 kinase domain dto:DTO_61000296 Macrophage stimulating 1 receptor (c-met-related tyrosine kinase); CD136; CDw136; MST1R; PTK8; RON 200273 MST1R kinase domain dto:DTO_61000297 Serine/threonine kinase 3 (STE20 homolog, yeast); FLJ90748; KRS1; MST2; STK3 200274 MST2 kinase domain dto:DTO_61000298 Serine/threonine kinase 24 (STE20 homolog, yeast); MST3; MST3B; STE20; STK24; STK3 200275 MST3 kinase domain dto:DTO_61000299 Serine/threonine protein kinase MST4; MASK; MST4 200276 MST4 kinase domain dto:DTO_61000300 Mechanistic target of rapamycin (serine/threonine kinase); FLJ44809; FRAP; FRAP1; FRAP2; MTOR; RAFT1; RAPT1 200277 MTOR kinase domain dto:DTO_61000301 Muscle, skeletal, receptor tyrosine kinase; MGC126323; MGC126324; MUSK 200278 MUSK kinase domain dto:DTO_61000302 Myosin light chain kinase; DKFZp686I10125; FLJ12216; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK; MYLK1; smMLCK 200279 MYLK kinase domain dto:DTO_61000303 Myosin light chain kinase 2; KMLC; MLCK; MLCK2; MYLK2; skMLCK 200280 MYLK2 kinase domain dto:DTO_61000304 Myosin light chain kinase family, member 4; MYLK4; SgK085 200281 MYLK4 kinase domain dto:DTO_61000305 Myosin IIIA; DFNB30; MYO3A 200282 MYO3A kinase domain dto:DTO_61000306 Myosin IIIB; MYO3B 200283 MYO3B kinase domain dto:DTO_61000307 Serine/threonine kinase 38; NDR; NDR1; STK38 200284 NDR1 kinase domain dto:DTO_61000308 Serine/threonine kinase 38 like; KIAA0965; NDR2; STK38L 200285 NDR2 kinase domain dto:DTO_61000309 NIMA (never in mitosis gene a)-related kinase 1; DKFZp686D06121; DKFZp686K12169; KIAA1901; MGC138800; NEK1; NY-REN-55 200286 NEK1 kinase domain dto:DTO_61000310 NIMA (never in mitosis gene a)- related kinase 10 200481 NEK10 kinase domain dto:DTO_61000311 NIMA (never in mitosis gene a)-related kinase 11; FLJ23495; NEK11 200287 NEK11 kinase domain dto:DTO_61000312 Serine/threonine-protein kinase Nek2; NIMA (never in mitosis gene a)-related kinase 2; HsPK21; NEK2; NEK2A; NLK1 200288 NEK2 kinase domain dto:DTO_61000313 NIMA (never in mitosis gene a)-related kinase 3; HSPK36; MGC29949; NEK3 200289 NEK3 kinase domain dto:DTO_61000314 NIMA (never in mitosis gene a)-related kinase 4; MGC33171; NEK4; NRK2; pp12301; STK2 200290 NEK4 kinase domain dto:DTO_61000315 NIMA (never in mitosis gene a)-related kinase 5; MGC75495; NEK5 200291 NEK5 kinase domain dto:DTO_61000316 NIMA (never in mitosis gene a)-related kinase 6; NEK6; SID6-1512 200292 NEK6 kinase domain dto:DTO_61000317 NIMA (never in mitosis gene a)-related kinase 7; NEK7 200293 NEK7 kinase domain dto:DTO_61000318 NIMA (never in mitosis gene a)-related kinase 9; DKFZp434D0935; MGC138306; MGC16714; Nek8; NEK9; NERCC; NERCC1 200294 NEK9 kinase domain dto:DTO_61000319 Serine/threonine-protein kinase NIM1; MGC42105; NIM1 200295 NIM1 kinase domain dto:DTO_61000320 Serine/threonine-protein kinase NLK; Nemo-like kinase; DKFZp761G1211; FLJ21033 200296 NLK kinase domain dto:DTO_61000321 NUAK family, SNF1-like kinase, 1; ARK5; KIAA0537; NUAK1 200041 NUAK1 kinase domain dto:DTO_61000322 Serine/threonine-protein kinase OSR1; oxidative-stress responsive 1; KIAA1101; OSR1; OXSR1 200297 OSR1 kinase domain dto:DTO_61000323 P21 protein (Cdc42/Rac)-activated kinase 1; MGC130000; MGC130001; PAK1; PAKalpha 200302 PAK1 kinase domain dto:DTO_61000324 P21 protein (Cdc42/Rac)-activated kinase 2; PAK2; PAK65; PAKgamma 200303 PAK2 kinase domain dto:DTO_61000325 P21 protein (Cdc42/Rac)-activated kinase 3; bPAK; CDKN1A; hPAK3; MRX30; MRX47; OPHN3; PAK3; PAK3beta 200304 PAK3 kinase domain dto:DTO_61000326 P21 protein (Cdc42/Rac)-activated kinase 4; PAK4 200305 PAK4 kinase domain dto:DTO_61000327 P21 protein (Cdc42/Rac)-activated kinase 6; PAK5; PAK6 200306 PAK6 kinase domain dto:DTO_61000328 P21 protein (Cdc42/Rac)-activated kinase 7; KIAA1264; MGC26232; PAK5; PAK7 200307, 200308 PAK7 kinase domain dto:DTO_61000329 Cyclin-dependent kinase 17; CDK17; PCTAIRE2; PCTK2 200310 PCTK2 kinase domain dto:DTO_61000330 Cyclin-dependent kinase 18; CDK18; PCTAIRE; PCTAIRE3; PCTK3 200311 PCTK3 kinase domain dto:DTO_61000331 3-phosphoinositide dependent protein kinase-1; MGC20087; MGC35290; PDK1; PDPK1; PRO0461 200314 PDPK1 kinase domain dto:DTO_61000332 Calcium-dependent protein kinase 1; CDPK1; CPK; PFB0815w; PFCDPK1 200315 PFCDPK1(P.falciparum) kinase domain dto:DTO_61000333 Protein Kinase 5; cdk-related protein kinase 6; cyclin-dependent kinase; MAL13P1.279; PK5 200316 PFPK5(P.falciparum) kinase domain dto:DTO_61000334 Platelet-derived growth factor receptor, alpha polypeptide; CD140A; MGC74795; PDGFR2; PDGFR-2; PDGFRA; PDGFRalpha; PDGFR-alpha; RHEPDGFRA 200312 PGFRA kinase domain dto:DTO_61000335 Platelet-derived growth factor receptor, beta polypeptide; CD140B; JTK12; PDGFR; PDGFR1; PDGFRB; PDGFR-b; PDGFRbeta; PEGFR-beta 200313 PGFRB kinase domain dto:DTO_61000336 Phosphorylase kinase, gamma 1 (muscle); PHKG; PHKG1 200319 PHKG1 kinase domain dto:DTO_61000337 Phosphorylase kinase, gamma 2 (testis); GSD9C; PHKG2 200320 PHKG2 kinase domain dto:DTO_61000338 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; FLJ22055; PIP4K2C; PIP5K2C 200343 PI42C kinase domain dto:DTO_61000339 Phosphoinositide-3-kinase, class 2, beta polypeptide; C2-PI3K; DKFZp686G16234; PIK3C2B 200321 PIK3C2B kinase domain dto:DTO_61000340 Phosphoinositide-3-kinase, class 2, gamma polypeptide; MGC163149; PI3K-C2GAMMA; PIK3C2G 200322 PIK3C2G kinase domain dto:DTO_61000341 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200323 PIK3CA kinase domain dto:DTO_61000342 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200324 PIK3CA(C420R) kinase domain dto:DTO_61000343 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200325 PIK3CA(E542K) kinase domain dto:DTO_61000344 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200326 PIK3CA(E545A) kinase domain dto:DTO_61000345 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200327 PIK3CA(E545K) kinase domain dto:DTO_61000346 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200328 PIK3CA(H1047L) kinase domain dto:DTO_61000347 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200329 PIK3CA(H1047Y) kinase domain dto:DTO_61000348 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200330 PIK3CA(I800L) kinase domain dto:DTO_61000349 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200331 PIK3CA(M1043I) kinase domain dto:DTO_61000350 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha 200332 PIK3CA(Q546K) kinase domain dto:DTO_61000351 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; DKFZp779K1237; MGC133043; P110BETA; PI3K; PI3KBETA; PIK3C1; PIK3CB; PI3K-beta 200333 PIK3CB kinase domain dto:DTO_61000352 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; p110D; P110DELTA; PI3K; PIK3CD; PI3K-delta 200334 PIK3CD kinase domain dto:DTO_61000353 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; PI3CG; PI3K; PI3Kgamma; PIK3; PIK3CG 200335 PIK3CG kinase domain dto:DTO_61000354 Phosphatidylinositol 4-kinase, catalytic, beta; NPIK; PI4K92; PI4KB; PI4KBETA; PI4K-BETA; PI4KIIIBETA; PIK4CB 200336 PIK4CB kinase domain dto:DTO_61000355 Pim-1 oncogene; PIM; PIM1 200337 PIM1 kinase domain dto:DTO_61000356 Pim-2 oncogene; PIM2 200338 PIM2 kinase domain dto:DTO_61000357 Pim-3 oncogene; PIM3; pim-3 200339 PIM3 kinase domain dto:DTO_61000358 Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PIP5K1A 200340 PIP5K1A kinase domain dto:DTO_61000359 Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; KIAA0589; LCCS3; PIP5K1C; PIP5Kgamma; PIP5K-GAMMA; PIPKIg_v4 200341 PIP5K1C kinase domain dto:DTO_61000360 Phosphatidylinositol-5-phosphate 4-kinase, type II, beta; PI5P4KB; PIP4K2B; PIP5K2B; PIP5KIIB; PIP5KIIbeta 200342 PIP5K2B kinase domain dto:DTO_61000361 Protein kinase, cAMP-dependent, catalytic, alpha; MGC102831; MGC48865; PKAa; PKACA; PKAC-a; PKACalpha; PKAC-alpha; PRKACA 200344 PKAC-alpha kinase domain dto:DTO_61000362 Protein kinase, cAMP-dependent, catalytic, beta; DKFZp781I2452; MGC41879; MGC9320; PKAb; PKACB; PKAC-b; PKACbeta; PKAC-beta; PRKACB 200345 PKAC-beta kinase domain dto:DTO_61000363 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Protein kinase, membrane associated tyrosine/threonine 1; DKFZp547K1610; FLJ20093; MYT1 200346 PKMYT1 kinase domain dto:DTO_61000364 Protein kinase N1; DBK; MGC46204; PAK1; PAK-1; PKN; PKN1; PKN1/PRK1; PKN-ALPHA; PRK1; PRKCL1 200347 PKN1 kinase domain dto:DTO_61000365 Protein kinase N2; MGC150606; MGC71074; PAK2; Pak-2; PKN2; PKN2/PRK2; PRK2; PRKCL2; PRO2042 200348 PKN2 kinase domain dto:DTO_61000366 Transmembrane Serine/Threonine-Protein Kinase B; PKNB; Protein Kinase B; STPK B 200349 PKNB(M.tuberculosis) kinase domain dto:DTO_61000367 Serine/threonine-protein kinase PLK1; polo-like kinase 1 (Drosophila); PLK; PLK1; STPK13 200350 PLK1 kinase domain dto:DTO_61000368 Serine/threonine-protein kinase PLK2; polo-like kinase 2 (Drosophila); PLK2; SNK 200351 PLK2 kinase domain dto:DTO_61000369 Serine/threonine-protein kinase PLK3; polo-like kinase 3 (Drosophila); CNK; FNK; PLK3; PRK 200352 PLK3 kinase domain dto:DTO_61000370 Serine/threonine-protein kinase PLK4; polo-like kinase 4 (Drosophila); PLK4; SAK; STK18 200353 PLK4 kinase domain dto:DTO_61000371 Eukaryotic translation initiation factor 2-alpha kinase 2; EIF2AK1; EIF2AK2; MGC126524; PKR; PRKR 200364 PRKR kinase domain dto:DTO_61000372 Protein kinase, X-linked; PKX1; PRKX 200365 PRKX kinase domain dto:DTO_61000373 PRP4 pre-mRNA processing factor 4 homolog B (yeast); dJ1013A10.1; KIAA0536; PR4H; PRP4; PRP4H; PRP4K; PRPF4B 200366 PRP4 kinase domain dto:DTO_61000374 Protein tyrosine kinase 6; BRK; FLJ42088; PTK6 200056 PTK6 kinase domain dto:DTO_61000375 RAF proto-oncogene serine/threonine-protein kinase; CRAF; c-Raf; NS5; RAF1; Raf-1 200369 RAF1 kinase domain dto:DTO_61000376 Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1 200370 RET kinase domain dto:DTO_61000377 Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1 200371 RET(M918T) kinase domain dto:DTO_61000378 Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1 200372 RET(V804L) kinase domain dto:DTO_61000379 Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1 200373 RET(V804M) kinase domain dto:DTO_61000380 RIO kinase 1 (yeast); AD034; bA288G3.1; FLJ30006; MGC12903; RIOK1 200374 RIOK1 kinase domain dto:DTO_61000381 RIO kinase 2 (yeast); FLJ11159; RIO2; RIOK2 200375 RIOK2 kinase domain dto:DTO_61000382 RIO kinase 3 (yeast); DKFZp779L1370; RIOK3; SUDD 200376 RIOK3 kinase domain dto:DTO_61000383 Receptor-interacting serine/threonine-protein kinase 1; FLJ39204; RIP; RIP1; RIPK1 200377 RIPK1 kinase domain dto:DTO_61000384 Receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; CCK; GIG30; RICK; RIP2; RIPK2 200378 RIPK2 kinase domain dto:DTO_61000385 Receptor-interacting serine-threonine kinase 4; ANKK2; ANKRD3; DIK; MGC129992; MGC129993; PKK; RIP4 200379 RIPK4 kinase domain dto:DTO_61000386 Dual serine/threonine and tyrosine protein kinase; DSTYK; DustyPK; HDCMD38P; KIAA0472; RIP5; RIPK5; SgK496 200380 RIPK5 kinase domain dto:DTO_61000387 Rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; MGC131603; MGC43611; P160ROCK; PRO0435; ROCK1 200381 ROCK1 kinase domain dto:DTO_61000388 Rho-associated protein kinase 2; Rho-associated, coiled-coil containing protein kinase 2; KIAA0619; ROCK2 200382 ROCK2 kinase domain dto:DTO_61000389 C-ros oncogene 1 , receptor tyrosine kinase; c-ros-1; MCF3; ROS; ROS1 200383 ROS1 kinase domain dto:DTO_61000390 Ribosomal protein S6 kinase, 90kDa, polypeptide 4; MSK2; RPS6KA4; RSK-B 200389, 200390 RPS6KA4(Kin.Dom.1-N-terminal) kinase domain dto:DTO_61000391 Ribosomal protein S6 kinase, 90kDa, polypeptide 4; MSK2; MSK2~b; RPS6KA4; RSK-B 200391, 200392 RPS6KA4(Kin.Dom.2-C-terminal) kinase domain dto:DTO_61000392 Ribosomal protein S6 kinase, 90kDa, polypeptide 5; MGC1911; MSK1; MSPK1; RLPK; RPS6KA5 200393, 200394 RPS6KA5(Kin.Dom.1-N-terminal) kinase domain dto:DTO_61000393 Ribosomal protein S6 kinase, 90kDa, polypeptide 5; MGC1911; MSK1; MSK1~b; MSPK1; RLPK; RPS6KA5 200395, 200396 RPS6KA5(Kin.Dom.2-C-terminal) kinase domain dto:DTO_61000394 Ribosomal protein S6 kinase, 90kDa, polypeptide 1; HU-1; MAPKAPK1A; RPS6KA1; RSK; RSK1; RSK3 200384, 200399 RSK1(Kin.Dom.1-N-terminal) kinase domain dto:DTO_61000395 Ribosomal protein S6 kinase, 90kDa, polypeptide 1; HU-1; MAPKAPK1A; RPS6KA1; RSK; RSK1; RSK3 200385, 200400 RSK1(Kin.Dom.2-C-terminal) kinase domain dto:DTO_61000396 Ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS; HU-3; ISPK-1; MAPKAPK1B; MRX19; p90-RSK2; pp90RSK2; RPS6KA3; RSK; RSK2; S6K-alpha3 200388, 200401 RSK2(Kin.Dom.1-N-terminal) kinase domain dto:DTO_61000397 Ribosomal protein S6 kinase alpha 3; KS6A3; S6K-alpha-3; p90-RSK 3; MAPKAPK-1b; pp90RSK2 200475 RSK2(Kin.Dom.2-C-terminal) kinase domain dto:DTO_61000398 Ribosomal protein S6 kinase, 90kDa, polypeptide 2; HU-2; MAPKAPK1C; p90RSK; p90-RSK3; pp90RSK3; RPS6KA2; RSK; RSK1; RSK1/p90RSK; RSK3; S6K-alpha; S6K-alpha2 200386, 200402 RSK3(Kin.Dom.1-N-terminal) kinase domain dto:DTO_61000399 Ribosomal protein S6 kinase, 90kDa, polypeptide 2; HU-2; MAPKAPK1C; p90RSK; p90-RSK3; pp90RSK3; RPS6KA2; RSK; RSK1; RSK1/p90RSK; RSK3; S6K-alpha; S6K-alpha2 200387, 200403 RSK3(Kin.Dom.2-C-terminal) kinase domain dto:DTO_61000400 Ribosomal protein S6 kinase, 90kDa, polypeptide 6; PP90RSK4; RPS6KA6; RSK4 200397, 200404 RSK4(Kin.Dom.1-N-terminal) kinase domain dto:DTO_61000401 Ribosomal protein S6 kinase alpha 6; S6K-alpha-6; p90-RSK 6; pp90RSK4 200398, 200405 RSK4(Kin.Dom.2-C-terminal) kinase domain dto:DTO_61000402 Ribosomal protein S6 kinase, 70kDa, polypeptide 1; p70(S6K)-alpha; p70-alpha; p70S6K; p70-S6K; PS6K; RPS6KB1; S6K; S6K1; STK14A 200406 S6K1 kinase domain dto:DTO_61000403 SH3-binding domain kinase 1; Sbk; SBK1 200407 SBK1 kinase domain dto:DTO_61000404 Serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase 1; SGK 200476 SGK1 kinase domain dto:DTO_61000405 Putative uncharacterized serine/threonine-protein kinase (Sugen kinase 110); SgK110 200408 SgK110 kinase domain dto:DTO_61000406 Serine/threonine-protein kinase Sgk2; Serum/glucocorticoid-regulated kinase 2 201108 SGK2 kinase domain dto:DTO_61000407 Serine/threonine-protein kinase Sgk3; Serum/glucocorticoid-regulated kinase 3; CISK; DKFZp781N0293; SGKL 200409 SGK3 kinase domain dto:DTO_61000408 Serine/threonine-protein kinase SIK1; salt-inducible kinase 1; MSK; SIK; SIK1; SNF1LK 200410 SIK1 kinase domain dto:DTO_61000409 Serine/threonine-protein kinase SIK2; salt-inducible kinase 2; DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; SIK2; SNF1LK2 200411 SIK2 kinase domain dto:DTO_61000410 Serine/threonine-protein kinase SIK3; SIK family kinase 3; FLJ12240; KIAA0999; L19; QSK 200368 SIK3 kinase domain dto:DTO_61000411 STE20-like serine/threonine-protein kinase; CTCL tumor antigen se20-9; bA16H23.1; KIAA0204; LOSK; MGC133067; se20-9; SLK; STK2 200412 SLK kinase domain dto:DTO_61000412 NUAK family, SNF1-like kinase, 2; DKFZp434J037; DKFZp686F01113; FLJ90349; NUAK2; SNARK 200413 SNARK kinase domain dto:DTO_61000413 SNF-related serine/threonine-protein kinase; SNF1-related kinase; DKFZp779A1866; FLJ20224; HSNFRK; KIAA0096; SNRK 200414 SNRK kinase domain dto:DTO_61000414 Proto-oncogene tyrosine-protein kinase Src; V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); ASV; c-SRC; p60-Src; SRC; SRC1 200415 SRC kinase domain dto:DTO_61000415 Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites; C20orf148; dJ697K14.1; SRM; SRMS 200416 SRMS kinase domain dto:DTO_61000416 SRSF protein kinase 1; SFRS protein kinase 1; Serine/arginine-rich protein-specific kinase 1; SFRSK1 200417 SRPK1 kinase domain dto:DTO_61000417 SFRS protein kinase 2; FLJ36101; SFRSK2; SRPK2 200418 SRPK2 kinase domain dto:DTO_61000418 SFRS protein kinase 3; MGC102944; MSSK1; SRPK3; STK23 200419 SRPK3 kinase domain dto:DTO_61000419 Serine/threonine kinase 16; FLJ39635; KRCT; MGC16211; MPSK; MPSK1; PKL12; STK16; TSF1 200420 STK16 kinase domain dto:DTO_61000420 Serine/threonine kinase 33 200421 STK33 kinase domain dto:DTO_61000421 Serine/threonine kinase 35; CLIK1; STK35; STK35L1 200422 STK35 kinase domain dto:DTO_61000422 Serine/threonine kinase 36, fused homolog (Drosophila); DKFZp434N0223; FU; Fused; KIAA1278; STK36 200423 STK36 kinase domain dto:DTO_61000423 STE20/SPS1-related proline-alanine-rich protein kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); DCHT; DKFZp686K05124; PASK; SPAK; STLK3 200424 STK39 kinase domain dto:DTO_61000424 Tyrosine-protein kinase SYK; spleen tyrosine kinase; p72-Syk; DKFZp313N1010; FLJ25043; FLJ37489; SYK 200425 SYK kinase domain dto:DTO_61000425 Mitogen-activated protein kinase kinase kinase 7; MAP3K7; MEKK7; TAK1; TGF1a 200426 TAK1 kinase domain dto:DTO_61000426 Serine/threonine-protein kinase TAO1; prostate-derived STE20-like kinase 2; hKFC-B; FLJ14314; KIAA1361; MAP3K16; MARKK; PSK2; TAO1; TAOK1 200427 TAOK1 kinase domain dto:DTO_61000427 Serine/threonine-protein kinase TAO2; prostate-derived sterile 20-like kinase 1; hKFC-C; KIAA0881; MAP3K17; PSK; PSK1; PSK1-BETA; TAO2; TAOK2 200428 TAOK2 kinase domain dto:DTO_61000428 Serine/threonine-protein kinase TAO3; TAO kinase 3; DKFZp666H245; DPK; FLJ31808; JIK; MAP3K18; TAO3 200429 TAOK3 kinase domain dto:DTO_61000429 Serine/threonine-protein kinase TBK1; TANK-binding kinase 1; NF-kappa-B-activating kinase; FLJ11330; NAK; T2K; TBK1 200430 TBK1 kinase domain dto:DTO_61000430 Tyrosine-protein kinase Tec; MGC126760; MGC126762; PSCTK4; TEC 200431 TEC kinase domain dto:DTO_61000431 Testis-specific kinase 1; TESK1 200432 TESK1 kinase domain dto:DTO_61000432 Transforming growth factor, beta receptor 1; AAT5; ACVRLK4; ALK5; ALK-5; LDS1A; LDS2A; SKR4; TGFBR1; TGFR-1 200433 TGFBR1 kinase domain dto:DTO_61000433 Transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS1B; LDS2B; MFS2; RIIC; TAAD2; TGFbeta-RII; TGFBR2; TGFR-2 200434 TGFBR2 kinase domain dto:DTO_61000434 Tyrosine-protein kinase receptor Tie-1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; JTK14; TIE; TIE1 200435 TIE1 kinase domain dto:DTO_61000435 Angiopoietin-1 receptor; TEK tyrosine kinase, endothelial; CD202B; TEK; TIE2; TIE-2; VMCM; VMCM1 200436 TIE2 kinase domain dto:DTO_61000436 Serine/threonine-protein kinase tousled-like 1; tousled-like kinase 1; KIAA0137; PKU-beta; TLK1 200437 TLK1 kinase domain dto:DTO_61000437 Serine/threonine-protein kinase tousled-like 2; tousled-like kinase 2; MGC44450; PKU-ALPHA; TLK2 200438 TLK2 kinase domain dto:DTO_61000438 TRAF2 and NCK interacting kinase; TNIK; TNIK/ZC2; ZC2 200439 TNIK kinase domain dto:DTO_61000439 Non-receptor tyrosine-protein kinase TNK1; MGC46193; TNK1 200440 TNK1 kinase domain dto:DTO_61000440 Tyrosine kinase, non-receptor, 2; ACK; ACK1; FLJ44758; FLJ45547; p21cdc42Hs; TNK2 200441 TNK2 kinase domain dto:DTO_61000441 TNNI3 interacting kinase; CARK; HH498; MGC142099; MGC33828; TNNI3K 200442 TNNI3K kinase domain dto:DTO_61000442 Neurotrophic tyrosine kinase, receptor, type 1; DKFZp781I14186; MTC; NTRK1; p140-TrkA; TRK; TRK1; TRKA; Trk-A 200443 TRKA kinase domain dto:DTO_61000443 Neurotrophic tyrosine kinase, receptor, type 2; GP145-TrkB; NTRK2; TRKB 200444 TRKB kinase domain dto:DTO_61000444 Neurotrophic tyrosine kinase, receptor, type 3; gp145(trkC); NTRK3; TRKC 200445 TRKC kinase domain dto:DTO_61000445 Transient receptor potential cation channel, subfamily M, member 6; ChaK2; HMGX; HOMG; HOMG1; HSH; TRPM6 200446 TRPM6 kinase domain dto:DTO_61000446 Testis-specific serine kinase 1B; FKSG81; SPOGA4; STK22D; TSSK1; TSSK1B 200447 TSSK1 kinase domain dto:DTO_61000447 TTK protein kinase; CT96; ESK; FLJ38280; MPS1; MPS1L1; PYT; TTK 200448 TTK kinase domain dto:DTO_61000448 TXK tyrosine kinase; BTKL; MGC22473; PSCTK5; PTK4; RLK; TKL; TXK 200449 TXK kinase domain dto:DTO_61000449 Non-receptor tyrosine-protein kinase TYK2; Tyrosine kinase 2; JTK1; TYK2 200450, 200452 TYK2(JH1domain-catalytic) kinase domain dto:DTO_61000450 Non-receptor tyrosine-protein kinase TYK2; Tyrosine kinase 2; JTK1; TYK2 200451, 200453 TYK2(JH2domain-pseudokinase) kinase domain dto:DTO_61000451 TYRO3 protein tyrosine kinase; BYK; Dtk; FLJ16467; RSE; Sky; Tif; TYRO3; Tyro3/Sky 200454 TYRO3 kinase domain dto:DTO_61000452 Serine/threonine-protein kinase ULK1; Unc-51-like kinase 1 (C. elegans); ATG1; FLJ38455; FLJ46475; ULK1; UNC51; Unc51.1 200455 ULK1 kinase domain dto:DTO_61000453 Serine/threonine-protein kinase ULK2; Unc-51-like kinase 2 (C. elegans); KIAA0623; ULK2; Unc51.2 200456 ULK2 kinase domain dto:DTO_61000454 Serine/threonine-protein kinase ULK3; Unc-51-like kinase 3 (C. elegans); DKFZp434C131; FLJ90566; ULK3 200457 ULK3 kinase domain dto:DTO_61000455 Vascular endothelial growth factor receptor 1; fms-related tyrosine kinase 1; vascular permeability factor receptor; FLT; FLT1; VEGFR1 200167 VGFR1 kinase domain dto:DTO_61000456 Vascular endothelial growth factor receptor 2; kinase insert domain receptor; CD309; FLK1; FLK-1; KDR; KRD-1; Ly73; VEGFR; VEGFR2; VEGFR-2 200458 VGFR2 kinase domain dto:DTO_61000457 Serine/threonine-protein kinase VRK2; vaccinia related kinase 2; VRK2 200459 VRK2 kinase domain dto:DTO_61000458 Wee1-like protein kinase; DKFZp686I18166; FLJ16446; WEE1; WEE1A; WEE1hu 200460 WEE1 kinase domain dto:DTO_61000459 Wee1-like protein kinase 2; FLJ16107; WEE1B; WEE2 200461 WEE2 kinase domain dto:DTO_61000460 WNK lysine deficient protein kinase 1; KDP; PSK; p65; HSN2; HSAN2; PRKWNK1 200477 WNK1 kinase domain dto:DTO_61000461 WNK lysine deficient protein kinase 3; PRKWNK3 200478 WNK3 kinase domain dto:DTO_61000462 Serine/threonine kinase 32A; MGC22688; STK32A; YANK1 200462 YANK1 kinase domain dto:DTO_61000463 Serine/threonine kinase 32B; HSA250839; STK32; STK32B; STKG6; YANK2 200463 YANK2 kinase domain dto:DTO_61000464 Serine/threonine kinase 32C; MGC23665; PKE; RP11-140A10.1; STK32C; YANK3 200464 YANK3 kinase domain dto:DTO_61000465 Tyrosine-protein kinase Yes; Proto-oncogene tyrosine-protein kinase Yes 200465 YES kinase domain dto:DTO_61000466 Serine/threonine-protein kinase 26 200466 YSK1 kinase domain dto:DTO_61000467 YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae); FLJ23074; MAP3K8; RCK; YSK4 200467 YSK4 kinase domain dto:DTO_61000468 Tyrosine-protein kinase ZAP-70; Zeta-chain (TCR) associated protein kinase 70kDa; FLJ17670; FLJ17679; SRK; STD; TZK; ZAP70; ZAP-70 200469 ZAP70 kinase domain 289 dto:DTO_62000005 ASN289 in WEE2 376 dto:DTO_62000006 ASN376 in WEE1 105 dto:DTO_62000007 GLN105 in ERK4 105 dto:DTO_62000008 GLN105 in MK01 108 dto:DTO_62000009 GLN108 in ERK3 118 dto:DTO_62000010 GLN118 in SgK110 122 dto:DTO_62000011 GLN122 in MK03 128 dto:DTO_62000012 GLN128 in SBK1 600 dto:DTO_62000013 GLN600 in JAK3(Kin.Dom.2) 626 dto:DTO_62000014 GLN626 in JAK2(Kin.Dom.2) 667 dto:DTO_62000015 GLU667 in JAK1(Kin.Dom.2) 866 dto:DTO_62000016 GLY866 in BUB1 108 dto:DTO_62000017 ILE108 in SLK 110 dto:DTO_62000018 ILE110 in LOK 1323 dto:DTO_62000019 ILE1323 in MAP3K1 332 dto:DTO_62000020 ILE332 in KPCI 642 dto:DTO_62000021 ILE642 in ERN1 711 dto:DTO_62000022 ILE711 in EPHA7 902 dto:DTO_62000023 ILE902 in TIE2 917 dto:DTO_62000024 ILE917 in TIE1 100 dto:DTO_62000025 LEU100 in MYO3A 103 dto:DTO_62000026 LEU103 in DAPK2 106 dto:DTO_62000027 LEU106 in MYO3B 110 dto:DTO_62000028 LEU110 in BRSK1 110 dto:DTO_62000029 LEU110 in DRAK2 111 dto:DTO_62000030 LEU111 in NEK7 115 dto:DTO_62000031 LEU115 in RPS6KA4(Kin.Dom.1-N-terminal) 1157 dto:DTO_62000032 LEU1157 in MET 1157 dto:DTO_62000033 LEU1157 in MET(M1250T) 1157 dto:DTO_62000034 LEU1157 in MET(Y1235D) 116 dto:DTO_62000035 LEU116 in CSNK1G3 116 dto:DTO_62000036 LEU116 in PIM2 1161 dto:DTO_62000037 LEU1161 in MST1R 118 dto:DTO_62000038 LEU118 in KC1G1 118 dto:DTO_62000039 LEU118 in KCC4 119 dto:DTO_62000040 LEU119 in KC1G2 1196 dto:DTO_62000041 LEU1196 in ALK 1196 dto:DTO_62000042 LEU1196 in ALK(C1156Y) 1196 dto:DTO_62000043 LEU1196 in ALK(L1196M) 120 dto:DTO_62000044 LEU120 in AURKC 122 dto:DTO_62000045 LEU122 in NEK6 123 dto:DTO_62000046 LEU123 in PIM3 128 dto:DTO_62000047 LEU128 in NEK9 130 dto:DTO_62000048 LEU130 in PLK1 131 dto:DTO_62000049 LEU131 in RPS6KA5(Kin.Dom.1-N-terminal) 132 dto:DTO_62000050 LEU132 in GSK3B 137 dto:DTO_62000051 LEU137 in ERK5 138 dto:DTO_62000052 LEU138 in DRAK1 138 dto:DTO_62000053 LEU138 in RSK3(Kin.Dom.1-N-terminal) 139 dto:DTO_62000054 LEU139 in PLK3 141 dto:DTO_62000055 LEU141 in RSK1(Kin.Dom.1-N-terminal) 147 dto:DTO_62000056 LEU147 in RSK2(Kin.Dom.1-N-terminal) 152 dto:DTO_62000057 LEU152 in RSK4(Kin.Dom.1-N-terminal) 1538 dto:DTO_62000058 LEU1538 in MYLK 154 dto:DTO_62000059 LEU154 in AURKB 159 dto:DTO_62000060 LEU159 in PDPK1 159 dto:DTO_62000061 LEU159 in PLK2 172 dto:DTO_62000062 LEU172 in S6K1 173 dto:DTO_62000063 LEU173 in SGK2 176 dto:DTO_62000064 LEU176 in SGK1 195 dto:DTO_62000065 LEU195 in GSK3A 2026 dto:DTO_62000066 LEU2026 in ROS1 210 dto:DTO_62000067 LEU210 in AURKA 211 dto:DTO_62000068 LEU211 in PIM1 240 dto:DTO_62000069 LEU240 in SGK3 264 dto:DTO_62000070 LEU264 in GRK4 301 dto:DTO_62000071 LEU301 in CHK2 431 dto:DTO_62000072 LEU431 in DCAMKL3 483 dto:DTO_62000073 LEU483 in RPS6KA4(Kin.Dom.2-C-terminal) 530 dto:DTO_62000074 LEU530 in KGP2 538 dto:DTO_62000075 LEU538 in TLK1 544 dto:DTO_62000076 LEU544 in TLK2 590 dto:DTO_62000077 LEU590 in LTK 603 dto:DTO_62000078 LEU603 in TYRO3 620 dto:DTO_62000079 LEU620 in AXL 671 dto:DTO_62000080 LEU671 in MERTK 84 dto:DTO_62000081 LEU84 in CHEK1 86 dto:DTO_62000082 LEU86 in MELK 89 dto:DTO_62000083 LEU89 in PLK4 92 dto:DTO_62000084 LEU92 in SNRK 93 dto:DTO_62000085 LEU93 in DAPK1 93 dto:DTO_62000086 LEU93 in DAPK3 95 dto:DTO_62000087 LEU95 in BRSK2 98 dto:DTO_62000088 LEU98 in STK16 101 dto:DTO_62000089 MET101 in TAOK3 102 dto:DTO_62000090 MET102 in MAPKAPK5 102 dto:DTO_62000091 MET102 in MST1 104 dto:DTO_62000092 MET104 in AMPK-alpha1 104 dto:DTO_62000093 MET104 in TAK1 105 dto:DTO_62000094 MET105 in MAP4K4 105 dto:DTO_62000095 MET105 in MINK 105 dto:DTO_62000096 MET105 in TAOK1 105 dto:DTO_62000097 MET105 in TAOK2 105 dto:DTO_62000098 MET105 in TNIK 1059 dto:DTO_62000099 MET1059 in INSRR 107 dto:DTO_62000100 MET107 in MK13 1079 dto:DTO_62000101 MET1079 in IGF1R 108 dto:DTO_62000102 MET108 in JNK1 108 dto:DTO_62000103 MET108 in MK09 109 dto:DTO_62000104 MET109 in MK12 1103 dto:DTO_62000105 MET1103 in INSR 111 dto:DTO_62000106 MET111 in MST3 1140 dto:DTO_62000107 MET1140 in YSK4 121 dto:DTO_62000108 MET121 in PKAC-alpha 121 dto:DTO_62000109 MET121 in PKAC-beta 121 dto:DTO_62000110 MET121 in VRK2 126 dto:DTO_62000111 MET126 in AAK1 126 dto:DTO_62000112 MET126 in PRKX 129 dto:DTO_62000113 MET129 in LKB1 129 dto:DTO_62000114 MET129 in MARK2 129 dto:DTO_62000115 MET129 in MP2K6 129 dto:DTO_62000116 MET129 in SNARK 130 dto:DTO_62000117 MET130 in BIKE 132 dto:DTO_62000118 MET132 in MARK3 132 dto:DTO_62000119 MET132 in NUAK1 135 dto:DTO_62000120 MET135 in MARK4 136 dto:DTO_62000121 MET136 in MARK1 138 dto:DTO_62000122 MET138 in MAPKAPK2 138 dto:DTO_62000123 MET138 in STK39 140 dto:DTO_62000124 MET140 in HUNK 140 dto:DTO_62000125 MET140 in MP2K3 1419 dto:DTO_62000126 MET1419 in MAP3K4 143 dto:DTO_62000127 MET143 in MP2K1 146 dto:DTO_62000128 MET146 in JNK3 147 dto:DTO_62000129 MET147 in MP2K2 148 dto:DTO_62000130 MET148 in DMPK 148 dto:DTO_62000131 MET148 in DMPK2 150 dto:DTO_62000132 MET150 in NIM1 153 dto:DTO_62000133 MET153 in MRCKB 153 dto:DTO_62000134 MET153 in ROCK1 154 dto:DTO_62000135 MET154 in MRCKA 166 dto:DTO_62000136 MET166 in NDR1 167 dto:DTO_62000137 MET167 in NDR2 169 dto:DTO_62000138 MET169 in ROCK2 174 dto:DTO_62000139 MET174 in CIT 174 dto:DTO_62000140 MET174 in MLK2 178 dto:DTO_62000141 MET178 in MP2K4 180 dto:DTO_62000142 MET180 in MYLK4 190 dto:DTO_62000143 MET190 in M3K12 192 dto:DTO_62000144 MET192 in STK33 193 dto:DTO_62000145 MET193 in MLK3 1947 dto:DTO_62000146 MET1947 in LRRK2 1947 dto:DTO_62000147 MET1947 in LRRK2(G2019S) 196 dto:DTO_62000148 MET196 in MP2K7 196 dto:DTO_62000149 MET196 in TNK1 220 dto:DTO_62000150 MET220 in MLK1 225 dto:DTO_62000151 MET225 in AKT3 227 dto:DTO_62000152 MET227 in AKT1 229 dto:DTO_62000153 MET229 in AKT2 233 dto:DTO_62000154 MET233 in M3K13 267 dto:DTO_62000155 MET267 in GRK1 268 dto:DTO_62000156 MET268 in GRK7 279 dto:DTO_62000157 MET279 in BMPR2 304 dto:DTO_62000158 MET304 in CTK 315 dto:DTO_62000159 MET315 in STK35 323 dto:DTO_62000160 MET323 in PAK2 344 dto:DTO_62000161 MET344 in PAK1 357 dto:DTO_62000162 MET357 in PAK3 359 dto:DTO_62000163 MET359 in MYLK2 366 dto:DTO_62000164 MET366 in PRKR 384 dto:DTO_62000165 MET384 in EIF2AK1 395 dto:DTO_62000166 MET395 in PAK4 414 dto:DTO_62000167 MET414 in ZAP70 427 dto:DTO_62000168 MET427 in KPCD 433 dto:DTO_62000169 MET433 in KPCL 437 dto:DTO_62000170 MET437 in M3K2 438 dto:DTO_62000171 MET438 in KGP1 443 dto:DTO_62000172 MET443 in MAP3K3 448 dto:DTO_62000173 MET448 in SYK 451 dto:DTO_62000174 MET451 in MAST1 458 dto:DTO_62000175 MET458 in KPCT 465 dto:DTO_62000176 MET465 in DCLK1 469 dto:DTO_62000177 MET469 in DCAMKL2 469 dto:DTO_62000178 MET469 in MAP3K14 481 dto:DTO_62000179 MET481 in PAK6 486 dto:DTO_62000180 MET486 in KPCE 486 dto:DTO_62000181 MET486 in RSK3(Kin.Dom.2-C-terminal) 498 dto:DTO_62000182 MET498 in RPS6KA5(Kin.Dom.2-C-terminal) 499 dto:DTO_62000183 MET499 in FAK1 502 dto:DTO_62000184 MET502 in FAK2 516 dto:DTO_62000185 MET516 in CDC2L1 523 dto:DTO_62000186 MET523 in PAK7 589 dto:DTO_62000187 MET589 in MLCK 602 dto:DTO_62000188 MET602 in TTK 604 dto:DTO_62000189 MET604 in NEK10 627 dto:DTO_62000190 MET627 in KPCD2 636 dto:DTO_62000191 MET636 in FES 637 dto:DTO_62000192 MET637 in FER 652 dto:DTO_62000193 MET652 in KPCD3 659 dto:DTO_62000194 MET659 in KPCD1 695 dto:DTO_62000195 MET695 in PKN1 722 dto:DTO_62000196 MET722 in M3K6 734 dto:DTO_62000197 MET734 in RIPK5 736 dto:DTO_62000198 MET736 in MAP3K15 737 dto:DTO_62000199 MET737 in PKN2 745 dto:DTO_62000200 MET745 in LATS2 754 dto:DTO_62000201 MET754 in M3K5 782 dto:DTO_62000202 MET782 in LATS1 79 dto:DTO_62000203 MET79 in NEK3 80 dto:DTO_62000204 MET80 in NEK1 80 dto:DTO_62000205 MET80 in NEK5 82 dto:DTO_62000206 MET82 in CSNK1D 82 dto:DTO_62000207 MET82 in CSNK1E 83 dto:DTO_62000208 MET83 in NEK4 85 dto:DTO_62000209 MET85 in ULK2 86 dto:DTO_62000210 MET86 in IKKE 86 dto:DTO_62000211 MET86 in NEK2 86 dto:DTO_62000212 MET86 in TBK1 90 dto:DTO_62000213 MET90 in CSNK1A1 90 dto:DTO_62000214 MET90 in CSNK1A1L 90 dto:DTO_62000215 MET90 in M4K3 90 dto:DTO_62000216 MET90 in MAP4K2 90 dto:DTO_62000217 MET90 in TSSK1 902 dto:DTO_62000218 MET902 in JAK3(JH1domain-catalytic) 91 dto:DTO_62000219 MET91 in M4K1 91 dto:DTO_62000220 MET91 in ULK3 92 dto:DTO_62000221 MET92 in OSR1 92 dto:DTO_62000222 MET92 in RIPK1 92 dto:DTO_62000223 MET92 in ULK1 929 dto:DTO_62000224 MET929 in JAK2(JH1domain-catalytic) 93 dto:DTO_62000225 MET93 in AMPK-alpha2 94 dto:DTO_62000226 MET94 in MAP4K5 95 dto:DTO_62000227 MET95 in CAMK1 95 dto:DTO_62000228 MET95 in IKKA 95 dto:DTO_62000229 MET95 in YSK1 956 dto:DTO_62000230 MET956 in JAK1(Kin.Dom.1) 96 dto:DTO_62000231 MET96 in IKKB 96 dto:DTO_62000232 MET96 in RIPK4 97 dto:DTO_62000233 MET97 in CAMK1G 98 dto:DTO_62000234 MET98 in ANKK1 98 dto:DTO_62000235 MET98 in CAMK1D 99 dto:DTO_62000236 MET99 in MST2 99 dto:DTO_62000237 MET99 in MST4 103 dto:DTO_62000238 PHE103 in CDK9 104 dto:DTO_62000239 PHE104 in PHKG1 107 dto:DTO_62000240 PHE107 in PHKG2 113 dto:DTO_62000241 PHE113 in CSNK2A1 114 dto:DTO_62000242 PHE114 in CSNK2A2 124 dto:DTO_62000243 PHE124 in MKNK1 159 dto:DTO_62000244 PHE159 in MKNK2 166 dto:DTO_62000245 PHE166 in SRPK2 178 dto:DTO_62000246 PHE178 in CDK15 190 dto:DTO_62000247 PHE190 in DYRK1B 210 dto:DTO_62000248 PHE210 in CDK14 217 dto:DTO_62000249 PHE217 in PCTK3 230 dto:DTO_62000250 PHE230 in KKCC1 238 dto:DTO_62000251 PHE238 in DYRK1A 239 dto:DTO_62000252 PHE239 in CLK4 240 dto:DTO_62000253 PHE240 in CDK16 241 dto:DTO_62000254 PHE241 in CLK1 243 dto:DTO_62000255 PHE243 in CLK2 267 dto:DTO_62000256 PHE267 in CAMKK2 267 dto:DTO_62000257 PHE267 in PCTK2 268 dto:DTO_62000258 PHE268 in HIPK1 275 dto:DTO_62000259 PHE275 in HIPK3 277 dto:DTO_62000260 PHE277 in HIPK2 301 dto:DTO_62000261 PHE301 in DYRK2 384 dto:DTO_62000262 PHE384 in CLK3 435 dto:DTO_62000263 PHE435 in ITK 589 dto:DTO_62000264 PHE589 in TRKA 609 dto:DTO_62000265 PHE609 in SRPK1 617 dto:DTO_62000266 PHE617 in TRKB 617 dto:DTO_62000267 PHE617 in TRKC 655 dto:DTO_62000268 PHE655 in MUSK 691 dto:DTO_62000269 PHE691 in FLT3 691 dto:DTO_62000270 PHE691 in FLT3(D835H) 691 dto:DTO_62000271 PHE691 in FLT3(D835Y) 691 dto:DTO_62000272 PHE691 in FLT3(ITD) 691 dto:DTO_62000273 PHE691 in FLT3(K663Q) 691 dto:DTO_62000274 PHE691 in FLT3(N841I) 691 dto:DTO_62000275 PHE691 in FLT3(R834Q) 691 dto:DTO_62000276 PHE691 in FLT3-autoinhibited 767 dto:DTO_62000277 PHE767 in PRP4 79 dto:DTO_62000278 PHE79 in CDKL3 79 dto:DTO_62000279 PHE79 in ICK 79 dto:DTO_62000280 PHE79 in MAK 791 dto:DTO_62000281 PHE791 in CDC2L5 80 dto:DTO_62000282 PHE80 in CDK2 80 dto:DTO_62000283 PHE80 in CDK3 80 dto:DTO_62000284 PHE80 in CDK5 80 dto:DTO_62000285 PHE80 in CDKL1 80 dto:DTO_62000286 PHE80 in CDKL2 89 dto:DTO_62000287 PHE89 in CAMK2A 89 dto:DTO_62000288 PHE89 in CDKL5 89 dto:DTO_62000289 PHE89 in HIPK4 90 dto:DTO_62000290 PHE90 in CAMK2B 90 dto:DTO_62000291 PHE90 in CAMK2G 90 dto:DTO_62000292 PHE90 in KCC2D 91 dto:DTO_62000293 PHE91 in CASK 91 dto:DTO_62000294 PHE91 in CDK7 92 dto:DTO_62000295 PHE92 in ERK8 93 dto:DTO_62000296 PHE93 in CDK4-cyclinD1 93 dto:DTO_62000297 PHE93 in CDK4-cyclinD3 97 dto:DTO_62000298 PHE97 in CDK11 97 dto:DTO_62000299 PHE97 in CDK8 280 dto:DTO_62000300 SER280 in TGFBR1 282 dto:DTO_62000301 SER282 in ACVR1B 103 dto:DTO_62000302 THR103 in SIK1 106 dto:DTO_62000303 THR106 in MK11 106 dto:DTO_62000304 THR106 in MK14 108 dto:DTO_62000305 THR108 in NEK11 123 dto:DTO_62000306 THR123 in GAK 129 dto:DTO_62000307 THR129 in TESK1 187 dto:DTO_62000308 THR187 in PKMYT1 205 dto:DTO_62000309 THR205 in TNK2 219 dto:DTO_62000310 THR219 in NLK 227 dto:DTO_62000311 THR227 in WNK3 241 dto:DTO_62000312 THR241 in MP2K5 264 dto:DTO_62000313 THR264 in PTK6 265 dto:DTO_62000314 THR265 in ACVR2B 266 dto:DTO_62000315 THR266 in CSK 267 dto:DTO_62000316 THR267 in ACVR2A 277 dto:DTO_62000317 THR277 in ACVRL1 279 dto:DTO_62000318 THR279 in BMPR1B 283 dto:DTO_62000319 THR283 in ACVR1 301 dto:DTO_62000320 THR301 in WNK1 302 dto:DTO_62000321 THR302 in SRMS 306 dto:DTO_62000322 THR306 in FRK 309 dto:DTO_62000323 THR309 in BMPR1A 312 dto:DTO_62000324 THR312 in BLK 315 dto:DTO_62000325 THR315 in ABL1(E255K) 315 dto:DTO_62000326 THR315 in ABL1(E255K)-phosphorylated 315 dto:DTO_62000327 THR315 in ABL1(F317I)-nonphosphorylated 315 dto:DTO_62000328 THR315 in ABL1(F317I)-phosphorylated 315 dto:DTO_62000329 THR315 in ABL1(F317L)-nonphosphorylated 315 dto:DTO_62000330 THR315 in ABL1(F317L)-phosphorylated 315 dto:DTO_62000331 THR315 in ABL1(H396P)-nonphosphorylated 315 dto:DTO_62000332 THR315 in ABL1(H396P)-phosphorylated 315 dto:DTO_62000333 THR315 in ABL1(M351T) 315 dto:DTO_62000334 THR315 in ABL1(M351T)-phosphorylated 315 dto:DTO_62000335 THR315 in ABL1(Q252H)-nonphosphorylated 315 dto:DTO_62000336 THR315 in ABL1(Q252H)-phosphorylated 315 dto:DTO_62000337 THR315 in ABL1(T315I)-nonphosphorylated 315 dto:DTO_62000338 THR315 in ABL1(T315I)-phosphorylated 315 dto:DTO_62000339 THR315 in ABL1(Y253F) 315 dto:DTO_62000340 THR315 in ABL1(Y253F)-phosphorylated 315 dto:DTO_62000341 THR315 in ABL1-nonphosphorylated 315 dto:DTO_62000342 THR315 in ABL1-phosphorylated 316 dto:DTO_62000343 THR316 in LCK 319 dto:DTO_62000344 THR319 in LYN 325 dto:DTO_62000345 THR325 in TGFBR2 333 dto:DTO_62000346 THR333 in HCK 334 dto:DTO_62000347 THR334 in FGR 341 dto:DTO_62000348 THR341 in SRC 342 dto:DTO_62000349 THR342 in FYN 343 dto:DTO_62000350 THR343 in TXK 348 dto:DTO_62000351 THR348 in YES 361 dto:DTO_62000352 THR361 in ABL2 405 dto:DTO_62000353 THR405 in LIMK2 413 dto:DTO_62000354 THR413 in LIMK1 421 dto:DTO_62000355 THR421 in RAF1 442 dto:DTO_62000356 THR442 in TEC 474 dto:DTO_62000357 THR474 in BTK 489 dto:DTO_62000358 THR489 in BMX 489 dto:DTO_62000359 THR489 in RSK1(Kin.Dom.2-C-terminal) 493 dto:DTO_62000360 THR493 in RSK2(Kin.Dom.2-C-terminal) 497 dto:DTO_62000361 THR497 in RSK4(Kin.Dom.2-C-terminal) 529 dto:DTO_62000362 THR529 in BRAF 529 dto:DTO_62000363 THR529 in BRAF(V600E) 539 dto:DTO_62000364 THR539 in TNNI3K 654 dto:DTO_62000365 THR654 in DDR2 663 dto:DTO_62000366 THR663 in CSF1R 663 dto:DTO_62000367 THR663 in CSF1R-autoinhibited 670 dto:DTO_62000368 THR670 in KIT 670 dto:DTO_62000369 THR670 in KIT(A829P) 670 dto:DTO_62000370 THR670 in KIT(D816H) 670 dto:DTO_62000371 THR670 in KIT(D816V) 670 dto:DTO_62000372 THR670 in KIT(L576P) 670 dto:DTO_62000373 THR670 in KIT(V559D) 670 dto:DTO_62000374 THR670 in KIT(V559D,T670I) 670 dto:DTO_62000375 THR670 in KIT(V559D,V654A) 670 dto:DTO_62000376 THR670 in KIT-autoinhibited 674 dto:DTO_62000377 THR674 in PGFRA 681 dto:DTO_62000378 THR681 in PGFRB 687 dto:DTO_62000379 THR687 in TYK2(JH1domain-catalytic) 687 dto:DTO_62000380 THR687 in TYK2(JH2domain-pseudokinase) 692 dto:DTO_62000381 THR692 in EPHA2 693 dto:DTO_62000382 THR693 in EPHB4 697 dto:DTO_62000383 THR697 in EPHB1 699 dto:DTO_62000384 THR699 in EPHA3 699 dto:DTO_62000385 THR699 in EPHA4 699 dto:DTO_62000386 THR699 in EPHB2 701 dto:DTO_62000387 THR701 in DDR1 702 dto:DTO_62000388 THR702 in EPHA1 711 dto:DTO_62000389 THR711 in EPHB3 713 dto:DTO_62000390 THR713 in EPHA8 748 dto:DTO_62000391 THR748 in EPHB6 753 dto:DTO_62000392 THR753 in EPHA5 787 dto:DTO_62000393 THR787 in ERBB3 790 dto:DTO_62000394 THR790 in EGFR 790 dto:DTO_62000395 THR790 in EGFR(E746-A750del) 790 dto:DTO_62000396 THR790 in EGFR(G719C) 790 dto:DTO_62000397 THR790 in EGFR(G719S) 790 dto:DTO_62000398 THR790 in EGFR(L747-E749del, A750P) 790 dto:DTO_62000399 THR790 in EGFR(L747-S752del, P753S) 790 dto:DTO_62000400 THR790 in EGFR(L747-T751del,Sins) 790 dto:DTO_62000401 THR790 in EGFR(L858R) 790 dto:DTO_62000402 THR790 in EGFR(L858R,T790M) 790 dto:DTO_62000403 THR790 in EGFR(L861Q) 790 dto:DTO_62000404 THR790 in EGFR(S752-I759del) 790 dto:DTO_62000405 THR790 in EGFR(T790M) 796 dto:DTO_62000406 THR796 in ERBB4 798 dto:DTO_62000407 THR798 in ERBB2 80 dto:DTO_62000408 THR80 in STK36 82 dto:DTO_62000409 THR82 in MLTK 84 dto:DTO_62000410 THR84 in SIK3 95 dto:DTO_62000411 THR95 in RIPK2 96 dto:DTO_62000412 THR96 in SIK2 241 dto:DTO_62000413 TYR241 in IRAK3 262 dto:DTO_62000414 TYR262 in IRAK4 288 dto:DTO_62000415 TYR288 in IRAK1 100 dto:DTO_62000416 VAL100 in YANK1 100 dto:DTO_62000417 VAL100 in YANK2 170 dto:DTO_62000418 VAL170 in YANK3 379 dto:DTO_62000419 VAL379 in GCN2(Kin.Dom.2,S808G) 550 dto:DTO_62000420 VAL550 in FGFR4 555 dto:DTO_62000421 VAL555 in FGFR3 555 dto:DTO_62000422 VAL555 in FGFR3(G697C) 561 dto:DTO_62000423 VAL561 in FGFR1 564 dto:DTO_62000424 VAL564 in FGFR2 751 dto:DTO_62000425 VAL751 in EPHA6 804 dto:DTO_62000426 VAL804 in RET 804 dto:DTO_62000427 VAL804 in RET(M918T) 804 dto:DTO_62000428 VAL804 in RET(V804L) 804 dto:DTO_62000429 VAL804 in RET(V804M) 909 dto:DTO_62000430 VAL909 in VGFR1 916 dto:DTO_62000431 VAL916 in VGFR2 927 dto:DTO_62000432 VAL927 in FLT4 dto:DTO_62000444 VAL dto:DTO_62100000 mutated residue 545 dto:DTO_62100002 A545 in PIK3CA(E545A) 746 dto:DTO_62100003 A746-A750del in EGFR(E746-A750del) 697 dto:DTO_62100004 C697 in FGFR3(G697C) 719 dto:DTO_62100005 C719 in EGFR(G719C) 1235 dto:DTO_62100006 D1235 in MET(Y1235D) 559 dto:DTO_62100007 D559 and A654 in KIT(V559D,V654A) 559 dto:DTO_62100008 D559 and I670 in KIT(V559D,T670I) 559 dto:DTO_62100009 D559 in KIT(V559D) 600 dto:DTO_62100010 E600 in BRAF(V600E) 253 dto:DTO_62100011 F253 in ABL1(Y253F) 253 dto:DTO_62100012 F253 in ABL1(Y253F)-phosphorylated 808 dto:DTO_62100013 G808 in GCN2(Kin.Dom.2,S808G) 252 dto:DTO_62100014 H252 in ABL1(Q252H)-nonphosphorylated 252 dto:DTO_62100015 H252 in ABL1(Q252H)-phosphorylated 816 dto:DTO_62100016 H816 in KIT(D816H) 835 dto:DTO_62100017 H835 in FLT3(D835H) 1043 dto:DTO_62100018 I1043 in PIK3CA(M1043I) 315 dto:DTO_62100019 I315 in ABL1(T315I)-nonphosphorylated 315 dto:DTO_62100020 I315 in ABL1(T315I)-phosphorylated 317 dto:DTO_62100021 I317 in ABL1(F317I)-nonphosphorylated 317 dto:DTO_62100022 I317 in ABL1(F317I)-phosphorylated 841 dto:DTO_62100023 I841 in FLT3(N841I) 0 dto:DTO_62100024 ITD in FLT3(ITD) 255 dto:DTO_62100025 K255 in ABL1(E255K) 255 dto:DTO_62100026 K255 in ABL1(E255K)-phosphorylated 542 dto:DTO_62100027 K542 in PIK3CA(E542K) 545 dto:DTO_62100028 K545 in PIK3CA(E545K) 546 dto:DTO_62100029 K546 in PIK3CA(Q546K) 1047 dto:DTO_62100030 L1047 in PIK3CA(H1047L) 317 dto:DTO_62100031 L317 in ABL1(F317L)-nonphosphorylated 317 dto:DTO_62100032 L317 in ABL1(F317L)-phosphorylated 747 dto:DTO_62100033 L747-E749del and P750 in EGFR(L747-E749del, A750P) 747 dto:DTO_62100034 L747-S752del and S753 in EGFR(L747-S752del, P753S) 800 dto:DTO_62100035 L800 in PIK3CA(I800L) 804 dto:DTO_62100036 L804 in RET(V804L) 1196 dto:DTO_62100037 M1196 in ALK(L1196M) 790 dto:DTO_62100038 M790 in EGFR(T790M) 804 dto:DTO_62100039 M804 in RET(V804M) 396 dto:DTO_62100040 P396 in ABL1(H396P)-nonphosphorylated 396 dto:DTO_62100041 P396 in ABL1(H396P)-phosphorylated 576 dto:DTO_62100042 P576 in KIT(L576P) 829 dto:DTO_62100043 P829 in KIT(A829P) 663 dto:DTO_62100044 Q663 in FLT3(K663Q) 834 dto:DTO_62100045 Q834 in FLT3(R834Q) 861 dto:DTO_62100046 Q861 in EGFR(L861Q) 420 dto:DTO_62100047 R420 in PIK3CA(C420R) 858 dto:DTO_62100048 R858 and M790 in EGFR(L858R,T790M) 858 dto:DTO_62100049 R858 in EGFR(L858R) 2019 dto:DTO_62100050 S2019 in LRRK2(G2019S) 719 dto:DTO_62100051 S719 in EGFR(G719S) 752 dto:DTO_62100052 S752-I759del in EGFR(S752-I759del) 1250 dto:DTO_62100053 T1250 in MET(M1250T) 351 dto:DTO_62100054 T351 in ABL1(M351T) 351 dto:DTO_62100055 T351 in ABL1(M351T)-phosphorylated 747 dto:DTO_62100056 T747-T751del and Silenced in EGFR(L747-T751del,Sins) 918 dto:DTO_62100057 T918 in RET(M918T) 816 dto:DTO_62100058 V816 in KIT(D816V) 1047 dto:DTO_62100059 Y1047 in PIK3CA(H1047Y) 1156 dto:DTO_62100060 Y1156 in ALK(C1156Y) 835 dto:DTO_62100061 Y835 in FLT3(D835Y) dto:DTO_62200000 phosphorylated residue dto:DTO_62300000 gatekeeper residue dto:DTO_63000000 Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models The kinase domain information from the pfam database. pfam domain dto:DTO_63000002 A Pfam protein family that includes ABC1 from yeast and AarF from E. coli . These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex [1] and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins. http://pfam.xfam.org/family/ABC1 http://pfam.xfam.org/family/PF01504 ABC1 dto:DTO_63000003 A Pfam protein family that is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains. http://pfam.xfam.org/family/Alpha_kinase Alpha_kinase dto:DTO_63000004 A Pfam protein family that is a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in insensitivity of cancer tumors to insulin and IGF1, and in calorie restriction. http://pfam.xfam.org/family/PI3_PI4_kinase PI3_PI4_kinase dto:DTO_63000005 A Pfam protein family that contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in [1]. The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyses the formation of phosphoinositol-4,5-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphinositide signaling pathway. PIP5K dto:DTO_63000006 A Pfam protein family that is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. They also function in embryonic development, physiological responses, and in the nervous and immune system. Abnormal phosphorylation causes many human diseases, including cancer, and drugs that affect phosphorylation can treat those diseases. http://pfam.xfam.org/family/PF00069 Pkinase dto:DTO_63000007 A Pfam protein family that attaches phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division.Tyrosine kinases are a subclass of protein kinase. http://pfam.xfam.org/family/Pkinase_Tyr Pkinase_Tyr dto:DTO_63000008 A Pfam protein family that is of atypical serine kinases which are found in archaea, bacteria and eukaryotes. Activity of Rio1 is vital in Saccharomyces cerevisiae for the processing of ribosomal RNA, as well as for proper cell cycle progression and chromosome http://pfam.xfam.org/family/RIO1 RIO1 ready for release pending final vetting axiom holds for all times 1.1.1 this person has role this investigator role (more colloquially: this person has this role of investigator) a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. has_role has role has role Protein Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Contact: Stephan Schurer stephan dot schurer at gmail dot com Created by: Saurabh Mehta, Nooshin Nabizadeh, Amar Koleti, Dusica Vidovic, Yu Asiyah Lin, Hande McGinty, Stephan Schurer* Release date: December 28, 2015 This file contains the axoims for chebi import DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 14 Feb 2018 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.1.1 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0 Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer* 2 Nov 2017 Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer. DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov). contact: Stephan Schurer: stephan dot schurer at gmail dot com DTO Drug Target Ontology 1.0