http://dx.doi.org/10.1186/2041-1480-4-30 http://orcid.org/0000-0002-1373-1705 http://orcid.org/0000-0002-7073-9172 https://orcid.org/0000-0001-5948-3092 https://orcid.org/0000-0002-0027-0858 A miscellaneous ontology of terms used for curation in FlyBase, including the DPO. https://creativecommons.org/licenses/by/4.0/ FlyBase Controlled Vocabulary (FBcv) 30:05:2025 10:40 FlyBase miscellaneous CV 1.2 2025-05-30 definition term replaced by If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R. is a defining property chain axiom where second argument is reflexive camcur BrainName official abbreviation BRAND NAME EmbDevSlim FORMULA FlyTed temp subset for edit tracking purposes Testis slim INN IUPAC NAME InChI InChIKey terms for rd test ontology SMILES Abnormal/normal slim Absent/present slim Attribute slim camcur cell_quality Terms to summarize typical use of a gene from one organism that is introduced into another organism primarily for use an experimental tool, rather than to study the function of the gene cur warning of impending obsoletion Term not to be used for direct annotation do not annotate Term not to be used for direct manual annotation MGI ribbon terms fbcvsubset_mgiribbons larval olfactory system lethal phase terms Relational slim: types of quality that require an additional entity in order to exist Systematic synonym Value slim subset_property synonym_type_property consider has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_format_version has_obo_namespace has_related_synonym has_scope id in_subset shorthand a core relation that holds between a part and its whole part of x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. preceded by x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. precedes has_age A relation between a developmental stage and another, larger developmental stage during which it happens. relationship FBdv:00018001 Creating this relation as a temporary fix, pending adding the axiom occurrent_part_of subproperty of happens_during to RO. substage of A relation between a developmental stage and another, larger developmental stage during which it happens. FBC:DPG a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. characteristic of Inverse of characteristic_of has characteristic a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. role of Primitive instance level timing relation between events before or simultaneous with t1 before t2 iff:= t1 before_or_simulataneous_with t2 and not (t1 simultaeous_with t2) before X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) ends after x overlaps y if and only if there exists some z such that x has part z and z part of y overlaps true x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y This is the transitive form of the develops from relation develops from inverse of develops from develops into A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. temporally related to x has developmental contribution from y iff x has some part z such that z develops from y has developmental contribution from inverse of has developmental contribution from developmentally contributes to Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from developmentally preceded by Inverse of developmentally preceded by developmentally succeeded by q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. characteristic of part of true A mereological relationship or a topological relationship mereotopologically related to A relationship that holds between entities participating in some developmental process (GO:0032502) developmentally related to is member of is a mereological relation between a item and a collection. member of has member is a mereological relation between a collection and an item. has member x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction). has developmental potential involving x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y has potential to developmentally contribute to x has the potential to develop into y iff x develops into y or if x is capable of developing into y This relation has a stronger meaning than merely indicating that X may develop into Y, in that the capability of developing into Y is always present, even if X does not always actually develop into Y. In particular, this means that if Y is restricted to a given taxon T, X is necessarily likewise restricted. has potential to develop into x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y has potential to directly develop into depends on q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2 towards A relation that holds between an attribute or a qualifier and another attribute. has modifier BFO:0000002 BFO:0000003 BFO:0000004 BFO:0000020 BFO:0000023 A naphthol carrying a hydroxy group at position 2. FooDB:FDB000877 HMDB:HMDB0012322 KEGG:C11713 MetaCyc:CPD-8131 PDBeChem:03V Wikipedia:2-Naphthol 2-Naphthol 2-naphthol chebi_ontology 2-Naftol 2-hydroxynaphthalene 2-naftolo 2-naphthalenol 2-naphtol Isonaphthol beta-Naftol beta-Naphthol beta-Naphtol beta-hydroxynaphthalene beta-naftolo beta-naphthol beta-naphthyl alcohol beta-naphthyl hydroxide CHEBI:10432 2-naphthol CHEBI:10432 2-Naphthol KEGG_COMPOUND 2-naphthol UniProt 2-Naftol ChemIDplus 2-hydroxynaphthalene HMDB 2-naftolo ChemIDplus 2-naphthalenol NIST_Chemistry_WebBook 2-naphtol ChemIDplus Isonaphthol ChemIDplus beta-Naftol ChemIDplus beta-Naphthol KEGG_COMPOUND beta-Naphtol ChemIDplus beta-hydroxynaphthalene ChemIDplus beta-hydroxynaphthalene NIST_Chemistry_WebBook beta-naftolo ChemIDplus beta-naphthol NIST_Chemistry_WebBook beta-naphthyl alcohol ChemIDplus beta-naphthyl hydroxide ChemIDplus Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV. KEGG:C05359 Wikipedia:Electron electron chebi_ontology Elektron beta beta(-) beta-particle e e(-) e- negatron CHEBI:10545 electron CHEBI:10545 electron ChEBI electron KEGG_COMPOUND Elektron ChEBI beta IUPAC beta(-) ChEBI beta-particle IUPAC e IUPAC e(-) UniProt e- KEGG_COMPOUND negatron IUPAC A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens. chebi_ontology dicarboxylic acids and derivatives CHEBI:131927 dicarboxylic acids and O-substituted derivatives CHEBI:131927 dicarboxylic acids and derivatives ChEBI Any member of the class of benzoquinones that is 1,4-benzoquinone or its C-substituted derivatives. chebi_ontology a quinone p-benzoquinones para-benzoquinones CHEBI:132124 1,4-benzoquinones CHEBI:132124 a quinone UniProt p-benzoquinones ChEBI para-benzoquinones ChEBI Any organic compound having an initial boiling point less than or equal to 250 degreeC (482 degreeF) measured at a standard atmospheric pressure of 101.3 kPa. Wikipedia:Volatile_organic_compound chebi_ontology VOC VOCs volatile organic compounds CHEBI:134179 volatile organic compound CHEBI:134179 VOC ChEBI VOCs ChEBI volatile organic compounds ChEBI An alkanesulfonate in which the carbon at position 1 is attached to R, which can represent hydrogens, a carbon chain, or other groups. CHEBI:22318 MetaCyc:Alkanesulfonates chebi_ontology alkanesulfonate oxoanions alkanesulfonates an alkanesulfonate CHEBI:134249 alkanesulfonate oxoanion CHEBI:134249 alkanesulfonate oxoanions ChEBI alkanesulfonates ChEBI an alkanesulfonate UniProt A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent. chebi_ontology Glykol CHEBI:13643 glycol CHEBI:13643 Glykol ChEBI A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent. chebi_ontology pro-agents proagent proagents CHEBI:136859 pro-agent CHEBI:136859 pro-agents ChEBI proagent ChEBI proagents ChEBI An atom of an element that exhibits properties that are between those of metals and nonmetals, or that has a mixture of them. The term generally includes boron, silicon, germanium, arsenic, antimony, and tellurium, while carbon, aluminium, selenium, polonium, and astatine are less commonly included. Wikipedia:Metalloid chebi_ontology metalloid metalloids CHEBI:137980 metalloid atom CHEBI:137980 metalloid ChEBI metalloids ChEBI An organic cation obtained by protonation of the amino group of any tertiary amino compound. chebi_ontology a tertiary amine tertiary amine(1+) tertiary ammonium ions CHEBI:137982 tertiary ammonium ion CHEBI:137982 a tertiary amine UniProt tertiary amine(1+) ChEBI tertiary ammonium ions ChEBI Any compound that can disrupt the functions of the endocrine (hormone) system Wikipedia:Endocrine_disruptor chebi_ontology endocrine disrupting chemical endocrine disrupting chemicals endocrine disrupting compound endocrine disrupting compounds endocrine disruptors endocrine-disrupting chemical endocrine-disrupting chemicals hormonally active agent hormonally active agents CHEBI:138015 endocrine disruptor CHEBI:138015 endocrine disrupting chemical ChEBI endocrine disrupting chemicals ChEBI endocrine disrupting compound ChEBI endocrine disrupting compounds ChEBI endocrine disruptors ChEBI endocrine-disrupting chemical ChEBI endocrine-disrupting chemicals ChEBI hormonally active agent ChEBI hormonally active agents ChEBI A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water. Wikipedia:Mineral_acid chebi_ontology inorganic acids mineral acid mineral acids CHEBI:138103 inorganic acid CHEBI:138103 inorganic acids ChEBI mineral acid ChEBI mineral acids ChEBI Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa). Wikipedia:https://en.wikipedia.org/wiki/Gas chebi_ontology gas molecular entities gaseous molecular entities gaseous molecular entity CHEBI:138675 gas molecular entity CHEBI:138675 gas molecular entities ChEBI gaseous molecular entities ChEBI gaseous molecular entity ChEBI Any molecular entity in which the isotopic ratio of nuclides for at least one element deviates measurably from that occurring in nature. The term includes both isotopically substituted compounds (in which essentially all the molecules of the compound have only the indicated nuclide(s) at each designated position) and isotopically labeled compounds (a formal mixture of an isotopically unmodified compound with one or more analogous isotopically substituted compound(s). chebi_ontology isotopically modified compounds CHEBI:139358 isotopically modified compound CHEBI:139358 isotopically modified compounds ChEBI Any isotopically modified compound that has one or more hydrogens replaced by tritium. chebi_ontology (3)H-labeled compound (3)H-labeled compounds (3)H-labelled compound (3)H-labelled compounds tritiated compounds tritium-labeled compound tritium-labeled compounds tritium-labelled compound tritium-labelled compounds CHEBI:139359 tritiated compound CHEBI:139359 tritium-labeled compound ChEBI tritium-labeled compounds ChEBI tritium-labelled compound ChEBI tritium-labelled compounds ChEBI (3)H-labeled compound ChEBI (3)H-labeled compounds ChEBI (3)H-labelled compound ChEBI (3)H-labelled compounds ChEBI tritiated compounds ChEBI carbamate chebi_ontology Carbamat Karbamat carbamate ion carbamic acid, ion(1-) CHEBI:13941 carbamate CHEBI:13941 carbamate UniProt Carbamat ChEBI Karbamat ChEBI carbamate ion ChemIDplus carbamic acid, ion(1-) ChemIDplus A chemical compound that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the compound. chebi_ontology sensitisers sensitizer sensitizers CHEBI:139492 sensitiser CHEBI:139492 sensitisers ChEBI sensitizer ChEBI sensitizers ChEBI Any phenol that acts as an electron donor. MetaCyc:Phenolic-Donors chebi_ontology a phenolic donor phenolic donors CHEBI:139520 phenolic donor CHEBI:139520 a phenolic donor UniProt phenolic donors ChEBI Any methoxyflavanone having a methoxy substituent located at position 4'. chebi_ontology a 4'-methoxyflavanone CHEBI:140332 4'-methoxyflavanones CHEBI:140332 a 4'-methoxyflavanone UniProt An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group glutamate(1-) chebi_ontology 2-ammoniopentanedioate glutamate glutamic acid monoanion CHEBI:14321 glutamate(1-) CHEBI:14321 glutamate(1-) JCBN 2-ammoniopentanedioate IUPAC glutamate UniProt glutamic acid monoanion JCBN Any agent that induces nausea and vomiting. chebi_ontology emetics CHEBI:149552 emetic CHEBI:149552 emetics ChEBI A molecular entity that can transfer an electron to another molecular entity. chebi_ontology Elektronendonator donneur d'electron CHEBI:15022 electron donor CHEBI:15022 Elektronendonator ChEBI donneur d'electron IUPAC A purine nucleobase found in humans and other organisms. ECMDB:ECMDB00292 KNApSAcK:C00019660 YMDB:YMDB00263 xanthine chebi_ontology 2,6-dioxopurine 2,6-dioxopurines xanthines CHEBI:15318 xanthine CHEBI:15318 xanthine ChEBI 2,6-dioxopurine ChEBI 2,6-dioxopurines ChEBI xanthines ChEBI A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity. CHEBI:13699 CHEBI:2377 KEGG:C00028 KEGG:C16722 Acceptor chebi_ontology A Akzeptor Hydrogen-acceptor Oxidized donor accepteur CHEBI:15339 acceptor CHEBI:15339 Acceptor KEGG_COMPOUND A KEGG_COMPOUND Akzeptor ChEBI Hydrogen-acceptor KEGG_COMPOUND Oxidized donor KEGG_COMPOUND accepteur ChEBI A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3. CHEBI:14061 CHEBI:23508 CHEBI:4050 KEGG:C00736 KNApSAcK:C00001351 KNApSAcK:C00007323 Wikipedia:Cysteine Cysteine cysteine chebi_ontology 2-Amino-3-mercaptopropionic acid 2-amino-3-mercaptopropanoic acid 2-amino-3-sulfanylpropanoic acid C Cys Cystein Hcys Zystein cisteina CHEBI:15356 cysteine CHEBI:15356 Cysteine KEGG_COMPOUND cysteine ChEBI 2-Amino-3-mercaptopropionic acid KEGG_COMPOUND 2-amino-3-mercaptopropanoic acid JCBN 2-amino-3-sulfanylpropanoic acid IUPAC C ChEBI Cys ChEBI Cystein ChEBI Hcys IUPAC Zystein ChEBI cisteina ChEBI A large group of antibiotics isolated from various species of Streptomyces and characterised by having a substituted phenoxazine ring linked to two cyclic heterodetic peptides. CHEBI:13723 CHEBI:22220 CHEBI:2445 KEGG:C01775 Actinomycin chebi_ontology actinomycins CHEBI:15369 actinomycin CHEBI:15369 Actinomycin KEGG_COMPOUND actinomycins ChEBI The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes). CHEBI:10744 CHEBI:13357 CHEBI:5584 KEGG:C00080 Hydron chebi_ontology H(+) H+ CHEBI:15378 hydron CHEBI:15378 Hydron KEGG_COMPOUND H(+) UniProt H+ KEGG_COMPOUND Any alpha-amino acid having L-configuration at the alpha-carbon. CHEBI:13072 CHEBI:13243 CHEBI:13797 CHEBI:21224 CHEBI:6175 KEGG:C00151 L-alpha-amino acid chebi_ontology L-2-Amino acid L-Amino acid L-alpha-amino acids CHEBI:15705 L-alpha-amino acid CHEBI:15705 L-alpha-amino acid IUPAC L-2-Amino acid KEGG_COMPOUND L-Amino acid KEGG_COMPOUND L-alpha-amino acids ChEBI A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects. CHEBI:14276 CHEBI:24081 HMDB:HMDB0000142 KEGG:C00058 MetaCyc:FORMATE Wikipedia:Formate formate chebi_ontology HCO2 anion aminate formiate formic acid, ion(1-) formylate hydrogen carboxylate methanoate CHEBI:15740 formate CHEBI:15740 formate UniProt HCO2 anion NIST_Chemistry_WebBook aminate ChEBI formiate ChEBI formic acid, ion(1-) ChemIDplus formylate ChEBI hydrogen carboxylate ChEBI methanoate ChEBI Any N-acyl-amino acid in which the amino acid moiety has D configuration. CHEBI:12474 CHEBI:21631 CHEBI:7224 chebi_ontology CHEBI:15778 N-acyl-D-amino acid CHEBI:15778 An optically active form of glutamic acid having D-configuration. CHEBI:21023 CHEBI:4183 DrugBank:DB02517 HMDB:HMDB0003339 KEGG:C00217 KNApSAcK:C00019577 MetaCyc:D-GLT PDBeChem:DGL D-Glutamic acid chebi_ontology (R)-2-aminopentanedioic acid D-2-Aminoglutaric acid D-Glutaminic acid D-Glutaminsaeure DGL glutamic acid D-form CHEBI:15966 D-glutamic acid CHEBI:15966 D-Glutamic acid KEGG_COMPOUND (R)-2-aminopentanedioic acid ChEBI D-2-Aminoglutaric acid KEGG_COMPOUND D-Glutaminic acid KEGG_COMPOUND D-Glutaminsaeure ChEBI DGL PDBeChem glutamic acid D-form ChemIDplus A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues. CHEBI:13672 CHEBI:14859 CHEBI:8312 KEGG:C00419 Polynucleotide chebi_ontology polynucleotides CHEBI:15986 polynucleotide CHEBI:15986 Polynucleotide KEGG_COMPOUND polynucleotides ChEBI An optically active form of glutamic acid having L-configuration. CHEBI:21304 CHEBI:42825 CHEBI:6224 BPDB:2297 DrugBank:DB00142 HMDB:HMDB0000148 KEGG:C00025 KEGG:D00007 KNApSAcK:C00001358 LINCS:LSM-36375 MetaCyc:GLT PDBeChem:GLU_LFOH Wikipedia:L-Glutamic_Acid L-Glutamic acid chebi_ontology (S)-2-aminopentanedioic acid (S)-glutamic acid E GLUTAMIC ACID Glu Glutamate L-Glu L-Glutaminic acid L-Glutaminsaeure CHEBI:16015 L-glutamic acid CHEBI:16015 L-Glutamic acid KEGG_COMPOUND (S)-2-aminopentanedioic acid ChEBI (S)-glutamic acid NIST_Chemistry_WebBook E ChEBI GLUTAMIC ACID PDBeChem Glu ChEBI Glutamate KEGG_COMPOUND L-Glu ChEBI L-Glutaminic acid KEGG_COMPOUND L-Glutaminsaeure ChEBI A monoatomic monoanion resulting from the addition of an electron to any halogen atom. CHEBI:14384 CHEBI:5605 KEGG:C00462 chebi_ontology HX Halide a halide anion halide anions halide(1-) halides halogen anion CHEBI:16042 halide anion CHEBI:16042 HX KEGG_COMPOUND Halide KEGG_COMPOUND a halide anion UniProt halide anions ChEBI halide(1-) ChEBI halides ChEBI halogen anion ChEBI An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms. CHEBI:13405 CHEBI:13406 CHEBI:13407 CHEBI:13771 CHEBI:22533 CHEBI:44269 CHEBI:44284 CHEBI:44404 CHEBI:7434 HMDB:HMDB0000051 KEGG:C00014 KEGG:D02916 KNApSAcK:C00007267 MetaCyc:AMMONIA MolBase:930 PDBeChem:NH3 Wikipedia:Ammonia AMMONIA Ammonia chebi_ontology Ammoniak NH3 R-717 [NH3] ammoniac amoniaco spirit of hartshorn CHEBI:16134 ammonia CHEBI:16134 AMMONIA PDBeChem Ammonia KEGG_COMPOUND Ammoniak ChemIDplus NH3 IUPAC NH3 KEGG_COMPOUND R-717 ChEBI [NH3] MolBase ammoniac ChEBI amoniaco ChEBI spirit of hartshorn ChemIDplus A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid. CHEBI:15135 CHEBI:45687 CHEBI:9335 HMDB:HMDB0001448 KEGG:C00059 KEGG:D05963 MetaCyc:SULFATE PDBeChem:SO4 Wikipedia:Sulfate Sulfate sulfate chebi_ontology SO4(2-) SULFATE ION Sulfate anion(2-) Sulfate dianion Sulfate(2-) Sulfuric acid ion(2-) [SO4](2-) sulphate sulphate ion CHEBI:16189 sulfate CHEBI:16189 Sulfate KEGG_COMPOUND sulfate UniProt SO4(2-) IUPAC SULFATE ION PDBeChem Sulfate anion(2-) HMDB Sulfate dianion HMDB Sulfate(2-) HMDB Sulfuric acid ion(2-) HMDB [SO4](2-) IUPAC sulphate ChEBI sulphate ion ChEBI A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O). CHEBI:15292 CHEBI:27218 CHEBI:46379 CHEBI:9888 DrugBank:DB03904 ECMDB:ECMDB04172 HMDB:HMDB0000294 KEGG:C00086 KEGG:D00023 KNApSAcK:C00007314 MetaCyc:UREA PDBeChem:URE PPDB:1728 Wikipedia:Urea YMDB:YMDB00003 UREA Urea urea chebi_ontology 1728 Carbamide E927b H2NC(O)NH2 Harnstoff Karbamid carbonyldiamide ur uree CHEBI:16199 urea CHEBI:16199 UREA PDBeChem Urea KEGG_COMPOUND urea UniProt 1728 PPDB Carbamide KEGG_COMPOUND E927b ChEBI H2NC(O)NH2 ChEBI Harnstoff NIST_Chemistry_WebBook Karbamid ChEBI carbonyldiamide NIST_Chemistry_WebBook ur IUPAC uree ChEBI A 2-aminopurine carrying a 6-oxo substituent. CHEBI:14371 CHEBI:14372 CHEBI:24443 CHEBI:42948 CHEBI:5563 DrugBank:DB02377 HMDB:HMDB0000132 KEGG:C00242 KNApSAcK:C00001501 MetaCyc:GUANINE PDBeChem:GUN Wikipedia:Guanine GUANINE Guanine guanine chebi_ontology 2-Amino-6-hydroxypurine 2-amino-6-oxopurine G Gua CHEBI:16235 guanine CHEBI:16235 GUANINE PDBeChem Guanine KEGG_COMPOUND guanine UniProt 2-Amino-6-hydroxypurine KEGG_COMPOUND 2-amino-6-oxopurine ChEBI G ChEBI Gua CBN Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers. CHEBI:13694 CHEBI:26960 CHEBI:9340 KEGG:C00297 chebi_ontology RSR Sulfide Thioether organic sulfides thioethers CHEBI:16385 organic sulfide CHEBI:16385 RSR IUPAC Sulfide KEGG_COMPOUND Thioether KEGG_COMPOUND organic sulfides ChEBI thioethers IUPAC An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia. CHEBI:14638 CHEBI:25469 CHEBI:44619 CHEBI:7472 HMDB:HMDB0029751 KEGG:C00829 KNApSAcK:C00001259 MetaCyc:NAPHTHALENE PDBeChem:NPY PPDB:1312 Wikipedia:Naphthalene NAPHTHALENE Naphthalene naphthalene chebi_ontology Naphthalen Naphthalin naftaleno naftalina naphtalene naphtaline CHEBI:16482 naphthalene CHEBI:16482 NAPHTHALENE PDBeChem Naphthalene KEGG_COMPOUND naphthalene UniProt Naphthalen ChEBI Naphthalin NIST_Chemistry_WebBook naftaleno ChEBI naftalina ChEBI naphtalene ChEBI naphtaline ChEBI The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene. CHEBI:12837 CHEBI:15009 CHEBI:18927 CHEBI:49820 CHEBI:8730 HMDB:HMDB0003364 KEGG:C00472 KEGG:C15602 MetaCyc:P-BENZOQUINONE PDBeChem:PLQ Wikipedia:1,4-Benzoquinone 1,4-Benzoquinone 1,4-benzoquinone chebi_ontology 1,4-Benzochinon 2,5-Cyclohexadiene-1,4-dione Quinone benzo-1,4-quinone benzoquinone p-Benzoquinone p-Chinon p-quinone para-benzoquinone CHEBI:16509 1,4-benzoquinone CHEBI:16509 1,4-Benzoquinone KEGG_COMPOUND 1,4-benzoquinone NIST_Chemistry_WebBook 1,4-benzoquinone UniProt 1,4-Benzochinon ChEBI 2,5-Cyclohexadiene-1,4-dione KEGG_COMPOUND Quinone KEGG_COMPOUND benzo-1,4-quinone NIST_Chemistry_WebBook benzoquinone ChemIDplus p-Benzoquinone KEGG_COMPOUND p-Chinon NIST_Chemistry_WebBook p-quinone HMDB para-benzoquinone HMDB Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates. CHEBI:15131 CHEBI:23008 CHEBI:9318 Wikipedia:Carbohydrate chebi_ontology Kohlenhydrat Kohlenhydrate a carbohydrate carbohidrato carbohidratos glucide glucides glucido glucidos hydrates de carbone saccharide saccharides saccharidum CHEBI:16646 carbohydrate CHEBI:16646 Kohlenhydrat ChEBI Kohlenhydrate ChEBI a carbohydrate UniProt carbohidrato IUPAC carbohidratos IUPAC glucide ChEBI glucides ChEBI glucido ChEBI glucidos ChEBI hydrates de carbone ChEBI saccharide IUPAC saccharides IUPAC saccharidum ChEBI Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc. CHEBI:14753 CHEBI:25906 CHEBI:7990 KEGG:C00012 Peptide chebi_ontology Peptid peptido peptidos CHEBI:16670 peptide CHEBI:16670 Peptide KEGG_COMPOUND Peptid ChEBI peptido ChEBI peptidos ChEBI A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system. CHEBI:13876 CHEBI:22703 CHEBI:3025 CHEBI:41187 HMDB:HMDB0001505 KEGG:C01407 PDBeChem:BNZ Wikipedia:Benzene BENZENE Benzene benzene chebi_ontology Benzen Benzine Benzol Bicarburet of hydrogen Coal naphtha Mineral naphtha Phene Pyrobenzol Pyrobenzole [6]annulene benzole cyclohexatriene phenyl hydride CHEBI:16716 benzene CHEBI:16716 BENZENE PDBeChem Benzene KEGG_COMPOUND benzene ChEBI benzene UniProt Benzen IUPAC Benzine UM-BBD Benzol ChemIDplus Bicarburet of hydrogen ChemIDplus Coal naphtha ChemIDplus Mineral naphtha ChemIDplus Phene ChemIDplus Pyrobenzol ChemIDplus Pyrobenzole ChemIDplus [6]annulene NIST_Chemistry_WebBook benzole NIST_Chemistry_WebBook cyclohexatriene UM-BBD phenyl hydride UM-BBD CHEBI:12909 CHEBI:13625 CHEBI:20906 CHEBI:4097 KEGG:C00405 D-alpha-amino acid chebi_ontology D-Amino acid D-alpha-amino acids CHEBI:16733 D-alpha-amino acid CHEBI:16733 D-alpha-amino acid ChEBI D-Amino acid KEGG_COMPOUND D-alpha-amino acids ChEBI Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001. chebi_ontology glycans CHEBI:167559 glycan CHEBI:167559 glycans ChEBI An aldehyde resulting from the formal oxidation of methanol. CHEBI:14274 CHEBI:24077 CHEBI:337763 CHEBI:5142 DrugBank:DB03843 HMDB:HMDB0001426 KEGG:C00067 KEGG:D00017 MetaCyc:FORMALDEHYDE PDBeChem:FOR PPDB:359 Wikipedia:Formaldehyde FORMALDEHYDE Formaldehyde formaldehyde chebi_ontology FORMALIN Formaldehyd Formalin Methanal Methylene oxide Oxomethane Oxomethylene CHEBI:16842 formaldehyde CHEBI:16842 FORMALDEHYDE PDBeChem Formaldehyde KEGG_COMPOUND formaldehyde UniProt FORMALIN ChEMBL Formaldehyd NIST_Chemistry_WebBook Formalin KEGG_COMPOUND Methanal KEGG_COMPOUND Methylene oxide KEGG_COMPOUND Oxomethane KEGG_COMPOUND Oxomethylene KEGG_COMPOUND High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms. CHEBI:13302 CHEBI:21123 CHEBI:33698 CHEBI:4291 KEGG:C00039 Deoxyribonucleic acid chebi_ontology (Deoxyribonucleotide)m (Deoxyribonucleotide)n (Deoxyribonucleotide)n+m DNA DNAn DNAn+1 DNS Desoxyribonukleinsaeure deoxyribonucleic acids desoxyribose nucleic acid thymus nucleic acid CHEBI:16991 deoxyribonucleic acid CHEBI:16991 Deoxyribonucleic acid KEGG_COMPOUND (Deoxyribonucleotide)m KEGG_COMPOUND (Deoxyribonucleotide)n KEGG_COMPOUND (Deoxyribonucleotide)n+m KEGG_COMPOUND DNA IUPAC DNA KEGG_COMPOUND DNA UniProt DNAn KEGG_COMPOUND DNAn+1 KEGG_COMPOUND DNS ChEBI Desoxyribonukleinsaeure ChEBI deoxyribonucleic acids ChEBI desoxyribose nucleic acid ChemIDplus thymus nucleic acid ChEBI The D-enantiomer of phenylalanine. CHEBI:13007 CHEBI:21067 CHEBI:42207 CHEBI:4224 DrugBank:DB02556 ECMDB:ECMDB20144 KEGG:C02265 MetaCyc:CPD-216 PDBeChem:DPN YMDB:YMDB00995 D-PHENYLALANINE D-Phenylalanine chebi_ontology D-Phe D-alpha-Amino-beta-phenylpropionic acid DPN phenylalanine D-form CHEBI:16998 D-phenylalanine CHEBI:16998 D-PHENYLALANINE PDBeChem D-Phenylalanine KEGG_COMPOUND D-Phe ChEBI D-alpha-Amino-beta-phenylpropionic acid KEGG_COMPOUND DPN PDBeChem phenylalanine D-form ChemIDplus CHEBI:14271 CHEBI:49593 CHEBI:5113 KEGG:C00742 PDBeChem:F Fluoride fluoride chebi_ontology F(-) F- FLUORIDE ION Fluoride ion Fluorine anion CHEBI:17051 fluoride CHEBI:17051 Fluoride KEGG_COMPOUND fluoride UniProt F(-) IUPAC F- KEGG_COMPOUND FLUORIDE ION PDBeChem Fluoride ion KEGG_COMPOUND Fluorine anion NIST_Chemistry_WebBook A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H). CHEBI:13427 CHEBI:13646 CHEBI:24974 CHEBI:6127 CHEBI:8742 KEGG:C01450 Wikipedia:Ketone Ketone chebi_ontology Keton R-CO-R' a ketone cetone ketones CHEBI:17087 ketone CHEBI:17087 Ketone KEGG_COMPOUND Keton ChEBI R-CO-R' KEGG_COMPOUND a ketone UniProt cetone ChEBI ketones ChEBI A compound in which one or more of the OH groups of phosphoric acid have been replaced with an amino or substituted amino group. The term is commonly confined to the phosphoric triamides, P(=O)(NR2)3, since replacement of one or two OH groups produces phosphoramidic acids: P(=O)(OH)(NR2)2 , P(=O)(OH)2(NR2). CHEBI:14827 CHEBI:26076 CHEBI:8162 chebi_ontology phosphamide phosphamides phosphoramides CHEBI:17102 phosphoramide CHEBI:17102 phosphamide ChEBI phosphamides ChEBI phosphoramides ChEBI CHEBI:13367 CHEBI:5598 KEGG:C11481 PDBeChem:SO3 chebi_ontology Bisulfite HSO3(-) HSO3- Hydrogen sulfite [SO2(OH)](-) bisulfite bisulphite hydrogen sulfite(1-) hydrosulfite anion CHEBI:17137 hydrogensulfite CHEBI:17137 Bisulfite KEGG_COMPOUND HSO3(-) IUPAC HSO3- KEGG_COMPOUND Hydrogen sulfite KEGG_COMPOUND [SO2(OH)](-) IUPAC bisulfite ChemIDplus bisulphite ChemIDplus hydrogen sulfite(1-) ChemIDplus hydrosulfite anion ChemIDplus A hydroxyether which contains both an ether and alcohol functional groups. It is one of the most versatile classes of organic solvents which are commonly used in paints, cleaners, adhesives, pharmaceuticals and cosmetics. Wikipedia:Glycol_ethers chebi_ontology glycol ethers CHEBI:172390 glycol ether CHEBI:172390 glycol ethers ChEBI The 7H-tautomer of purine. CHEBI:14968 CHEBI:8639 HMDB:HMDB0001366 KEGG:C15587 chebi_ontology Purine Purine base CHEBI:17258 7H-purine CHEBI:17258 Purine KEGG_COMPOUND Purine base KEGG_COMPOUND The L-enantiomer of phenylalanine. CHEBI:13151 CHEBI:21370 CHEBI:44851 CHEBI:44885 CHEBI:45079 CHEBI:6282 DrugBank:DB00120 ECMDB:ECMDB00159 HMDB:HMDB0000159 KEGG:C00079 KEGG:D00021 KNApSAcK:C00001386 MetaCyc:PHE PDBeChem:PHE Wikipedia:Phenylalanine YMDB:YMDB00304 L-Phenylalanine chebi_ontology (S)-2-Amino-3-phenylpropionic acid (S)-alpha-Amino-beta-phenylpropionic acid 3-phenyl-L-alanine F PHENYLALANINE Phe beta-phenyl-L-alanine CHEBI:17295 L-phenylalanine CHEBI:17295 L-Phenylalanine KEGG_COMPOUND (S)-2-Amino-3-phenylpropionic acid HMDB (S)-alpha-Amino-beta-phenylpropionic acid KEGG_COMPOUND 3-phenyl-L-alanine NIST_Chemistry_WebBook F ChEBI PHENYLALANINE PDBeChem Phe ChEBI beta-phenyl-L-alanine NIST_Chemistry_WebBook Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. Wikipedia:Ferroptosis chebi_ontology ferroptosis inducers CHEBI:173085 ferroptosis inducer CHEBI:173085 ferroptosis inducers ChEBI A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3). CHEBI:15139 CHEBI:45548 PDBeChem:SO3 sulfite chebi_ontology SO3 SO3(2-) SULFITE ION [SO3](2-) sulphite CHEBI:17359 sulfite CHEBI:17359 sulfite UniProt SO3 ChEBI SO3(2-) IUPAC SULFITE ION PDBeChem [SO3](2-) IUPAC sulphite ChEBI A straight-chain saturated fatty acid containing five carbon atoms. CHEBI:113448 CHEBI:27263 CHEBI:27264 CHEBI:43606 CHEBI:44803 CHEBI:7980 DrugBank:DB02406 HMDB:HMDB0000892 KEGG:C00803 KNApSAcK:C00001208 PDBeChem:LEA PPDB:3130 Wikipedia:Valeric_acid Valeric acid chebi_ontology 1-butanecarboxylic acid CH3-[CH2]3-COOH PENTANOIC ACID Pentanoate Pentanoic acid Valerate Valerianic acid Valeriansaeure n-BuCOOH n-Pentanoate n-Valeric acid n-pentanoic acid n-valeric acid pentoic acid propylacetic acid valeric acid, normal CHEBI:17418 valeric acid CHEBI:17418 Valeric acid KEGG_COMPOUND 1-butanecarboxylic acid ChemIDplus 1-butanecarboxylic acid NIST_Chemistry_WebBook CH3-[CH2]3-COOH IUPAC PENTANOIC ACID PDBeChem Pentanoate KEGG_COMPOUND Pentanoic acid KEGG_COMPOUND Valerate KEGG_COMPOUND Valerianic acid KEGG_COMPOUND Valeriansaeure ChEBI n-BuCOOH ChEBI n-Pentanoate KEGG_COMPOUND n-Valeric acid KEGG_COMPOUND n-pentanoic acid ChemIDplus n-valeric acid ChemIDplus pentoic acid ChEBI propylacetic acid ChemIDplus valeric acid, normal ChemIDplus A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group. CHEBI:13432 CHEBI:13753 CHEBI:13805 CHEBI:13806 CHEBI:22291 CHEBI:2554 CHEBI:8750 KEGG:C00071 Aldehyde aldehyde chebi_ontology Aldehyd RC(=O)H RCHO aldehido aldehidos aldehydes aldehydum an aldehyde CHEBI:17478 aldehyde CHEBI:17478 Aldehyde KEGG_COMPOUND aldehyde ChEBI Aldehyd ChEBI RC(=O)H IUPAC RCHO KEGG_COMPOUND aldehido ChEBI aldehidos ChEBI aldehydes ChEBI aldehydum ChEBI an aldehyde UniProt The carbon oxoanion resulting from the removal of a proton from carbonic acid. CHEBI:13363 CHEBI:22863 CHEBI:40961 CHEBI:5589 HMDB:HMDB0000595 KEGG:C00288 MetaCyc:HCO3 PDBeChem:BCT Wikipedia:Bicarbonate Hydrogencarbonate hydrogencarbonate chebi_ontology Acid carbonate BICARBONATE ION Bicarbonate HCO3(-) HCO3- [CO2(OH)](-) hydrogen carbonate CHEBI:17544 hydrogencarbonate CHEBI:17544 Hydrogencarbonate KEGG_COMPOUND hydrogencarbonate UniProt Acid carbonate KEGG_COMPOUND BICARBONATE ION PDBeChem Bicarbonate KEGG_COMPOUND HCO3(-) IUPAC HCO3- KEGG_COMPOUND [CO2(OH)](-) IUPAC hydrogen carbonate PDBeChem A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription. CHEBI:15288 CHEBI:27210 CHEBI:46375 CHEBI:9882 DrugBank:DB03419 HMDB:HMDB0000300 KEGG:C00106 KEGG:D00027 KNApSAcK:C00001513 MetaCyc:URACIL PDBeChem:URA Wikipedia:Uracil URACIL Uracil uracil chebi_ontology 2,4(1H,3H)-pyrimidinedione 2,4-Dioxopyrimidine 2,4-Pyrimidinedione U Ura Urazil CHEBI:17568 uracil CHEBI:17568 URACIL PDBeChem Uracil KEGG_COMPOUND uracil UniProt 2,4(1H,3H)-pyrimidinedione NIST_Chemistry_WebBook 2,4-Dioxopyrimidine HMDB 2,4-Pyrimidinedione HMDB U ChEBI Ura CBN Urazil ChEBI The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent. CHEBI:15248 CHEBI:27022 CHEBI:44023 CHEBI:9624 DrugBank:DB01900 KEGG:C01455 PDBeChem:MBN Wikipedia:Toluene TOLUENE Toluene toluene chebi_ontology Toluen Toluol methylbenzene phenylmethane CHEBI:17578 toluene CHEBI:17578 TOLUENE PDBeChem Toluene KEGG_COMPOUND toluene ChEBI toluene UniProt Toluen NIST_Chemistry_WebBook Toluol NIST_Chemistry_WebBook methylbenzene PDBeChem phenylmethane ChemIDplus A straight chain alkane composed of 8 carbon atoms. CHEBI:14680 CHEBI:25465 CHEBI:25645 CHEBI:44621 CHEBI:7723 DrugBank:DB02440 HMDB:HMDB0001485 KEGG:C01387 MetaCyc:CPD-148 PDBeChem:OCT Wikipedia:Octane Octane octane chebi_ontology CH3-[CH2]6-CH3 N-OCTANE Oktan n-Octane n-Oktan CHEBI:17590 octane CHEBI:17590 Octane KEGG_COMPOUND octane UniProt CH3-[CH2]6-CH3 IUPAC N-OCTANE PDBeChem Oktan NIST_Chemistry_WebBook n-Octane KEGG_COMPOUND n-Oktan ChEBI A benzenediol comprising benzene core carrying two hydroxy substituents para to each other. CHEBI:14416 CHEBI:24645 CHEBI:5793 HMDB:HMDB0002434 KEGG:C00530 KEGG:C15603 KEGG:D00073 KNApSAcK:C00002656 MetaCyc:HYDROQUINONE PPDB:1503 Wikipedia:Hydroquinone Hydroquinone hydroquinone chebi_ontology 1,4-Benzenediol 1,4-Dihydroxybenzene 4-Hydroxyphenol Benzene-1,4-diol Eldoquin Quinol p-Benzenediol p-Hydroquinone p-hydroxyphenol CHEBI:17594 hydroquinone CHEBI:17594 Hydroquinone KEGG_COMPOUND hydroquinone UniProt 1,4-Benzenediol KEGG_COMPOUND 1,4-Dihydroxybenzene KEGG_COMPOUND 4-Hydroxyphenol KEGG_COMPOUND Benzene-1,4-diol KEGG_COMPOUND Eldoquin ChemIDplus Quinol KEGG_COMPOUND p-Benzenediol KEGG_COMPOUND p-Hydroquinone KEGG_COMPOUND p-hydroxyphenol NIST_Chemistry_WebBook Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. Wikipedia:Geroprotector chebi_ontology anti-aging agent anti-aging agents anti-aging drug anti-aging drugs geroprotective agent geroprotective agents geroprotectors CHEBI:176497 geroprotector CHEBI:176497 anti-aging agent ChEBI anti-aging agents ChEBI anti-aging drug ChEBI anti-aging drugs ChEBI geroprotective agent ChEBI geroprotective agents ChEBI geroprotectors ChEBI Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin. vitamin B9 chebi_ontology folate vitamer folate vitamers vitamin B-9 vitamin B9 vitamer vitamin B9 vitamers vitamins B9 CHEBI:176842 vitamin B9 CHEBI:176842 vitamin B9 ChEBI folate vitamer ChEBI folate vitamers ChEBI vitamin B-9 ChEBI vitamin B9 vitamer ChEBI vitamin B9 vitamers ChEBI vitamins B9 ChEBI CHEBI:13878 CHEBI:3027 KEGG:C01785 Benzenediol chebi_ontology dihydroxybenzene CHEBI:17701 benzenediol CHEBI:17701 Benzenediol KEGG_COMPOUND dihydroxybenzene ChEBI A pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. CHEBI:15244 CHEBI:19273 CHEBI:45782 CHEBI:45834 CHEBI:45917 CHEBI:9579 DrugBank:DB04485 HMDB:HMDB0000273 KEGG:C00214 KNApSAcK:C00019698 MetaCyc:THYMIDINE PDBeChem:THM Wikipedia:Thymidine THYMIDINE Thymidine thymidine chebi_ontology 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione 2'-deoxy-5-methyluridine 2'-deoxythymidine 2'-thymidine 5-methyl-2'-deoxyuridine Deoxythymidine T dThd thymine 2'-deoxyriboside CHEBI:17748 thymidine CHEBI:17748 THYMIDINE PDBeChem Thymidine KEGG_COMPOUND thymidine UniProt 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione ChEBI 2'-deoxy-5-methyluridine ChemIDplus 2'-deoxythymidine ChemIDplus 2'-thymidine ChEBI 5-methyl-2'-deoxyuridine ChemIDplus Deoxythymidine KEGG_COMPOUND T ChEBI dThd CBN thymine 2'-deoxyriboside ChEBI A compound containing at least one carbon-halogen bond (where X is a halogen atom). CHEBI:13444 CHEBI:36684 CHEBI:8767 KEGG:C01322 MetaCyc:Organohalogen-Compounds chebi_ontology RX organic halide organic halides organohalogen compounds CHEBI:17792 organohalogen compound CHEBI:17792 RX KEGG_COMPOUND RX UniProt organic halide KEGG_COMPOUND organic halides ChEBI organohalogen compounds ChEBI A pyrimidine nucleobase that is uracil in which the hydrogen at position 5 is replaced by a methyl group. CHEBI:15247 CHEBI:27004 CHEBI:46017 CHEBI:9580 DrugBank:DB03462 KEGG:C00178 KNApSAcK:C00001511 PDBeChem:TDR Wikipedia:Thymine THYMINE Thymine thymine chebi_ontology 2,4-dihydroxy-5-methylpyrimidine 5-Methyluracil 5-methyl-2,4(1H,3H)-pyrimidinedione 5-methylpyrimidine-2,4(1H,3H)-dione 5-methyluracil T Thy Thymin CHEBI:17821 thymine CHEBI:17821 THYMINE PDBeChem Thymine KEGG_COMPOUND thymine UniProt 2,4-dihydroxy-5-methylpyrimidine NIST_Chemistry_WebBook 5-Methyluracil KEGG_COMPOUND 5-methyl-2,4(1H,3H)-pyrimidinedione NIST_Chemistry_WebBook 5-methylpyrimidine-2,4(1H,3H)-dione IUPAC 5-methyluracil NIST_Chemistry_WebBook T ChEBI Thy CBN Thymin ChemIDplus A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms. CHEBI:13364 CHEBI:24635 CHEBI:5590 HMDB:HMDB0002306 KEGG:C01327 KEGG:D02057 MetaCyc:HCL Wikipedia:HCl Wikipedia:Hydrochloric_acid Hydrogen chloride chebi_ontology Chlorwasserstoff HCl Hydrochloride Hydrogenchlorid Wasserstoffchlorid [HCl] chlorure d'hydrogene cloruro de hidrogeno hydrochloric acid CHEBI:17883 hydrogen chloride CHEBI:17883 Hydrogen chloride KEGG_COMPOUND Chlorwasserstoff ChEBI HCl KEGG_COMPOUND Hydrochloride KEGG_COMPOUND Hydrogenchlorid ChEBI Wasserstoffchlorid ChEBI [HCl] IUPAC chlorure d'hydrogene ChEBI cloruro de hidrogeno ChEBI hydrochloric acid ChemIDplus A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity. CHEBI:14202 CHEBI:4697 KEGG:C01351 Donor chebi_ontology Donator donneur CHEBI:17891 donor CHEBI:17891 Donor KEGG_COMPOUND Donator ChEBI donneur ChEBI A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages. CHEBI:15295 CHEBI:27225 CHEBI:9892 DrugBank:DB04827 HMDB:HMDB0031219 KEGG:C01537 LINCS:LSM-37020 Wikipedia:Ethyl_carbamate Urethane urethane chebi_ontology Ethyl carbamate carbamic acid ethyl ester CHEBI:17967 urethane CHEBI:17967 Urethane KEGG_COMPOUND urethane UniProt Ethyl carbamate KEGG_COMPOUND carbamic acid ethyl ester ChEBI A halide anion formed when chlorine picks up an electron to form an an anion. CHEBI:13291 CHEBI:13970 CHEBI:3616 CHEBI:3731 CHEBI:48804 FooDB:FDB006557 HMDB:HMDB0000492 KEGG:C00698 MetaCyc:CL- PDBeChem:CL Wikipedia:Chloride Chloride chloride chebi_ontology CHLORIDE ION Chloride ion Chloride(1-) Chlorine anion Cl(-) Cl- CHEBI:17996 chloride CHEBI:17996 Chloride KEGG_COMPOUND chloride UniProt CHLORIDE ION PDBeChem Chloride ion KEGG_COMPOUND Chloride(1-) ChemIDplus Chlorine anion NIST_Chemistry_WebBook Cl(-) IUPAC Cl- KEGG_COMPOUND 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids. CHEBI:14517 CHEBI:25054 CHEBI:6486 KEGG:C01356 Lipid chebi_ontology CHEBI:18059 lipid CHEBI:18059 Lipid KEGG_COMPOUND CHEBI:13368 CHEBI:37140 CHEBI:5599 hydrogen halide chebi_ontology hydrogen halides CHEBI:18140 hydrogen halide CHEBI:18140 hydrogen halide IUPAC hydrogen halides ChEBI An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2. CHEBI:24314 CHEBI:5431 KEGG:C00302 KEGG:D04341 KNApSAcK:C00001358 KNApSAcK:C00019577 Wikipedia:Glutamic_acid Glutamic acid chebi_ontology 2-Aminoglutaric acid DL-Glutamic acid DL-Glutaminic acid E Glu Glutamate Glutaminic acid Glutaminsaeure CHEBI:18237 glutamic acid CHEBI:18237 Glutamic acid KEGG_COMPOUND 2-Aminoglutaric acid KEGG_COMPOUND DL-Glutamic acid KEGG_DRUG DL-Glutaminic acid KEGG_COMPOUND E ChEBI Glu ChEBI Glutamate KEGG_COMPOUND Glutaminic acid KEGG_COMPOUND Glutaminsaeure ChEBI Any nucleoside where the sugar component is D-ribose. CHEBI:13014 CHEBI:13015 CHEBI:13685 CHEBI:21085 CHEBI:26560 CHEBI:4240 CHEBI:8844 KEGG:C00911 Ribonucleoside chebi_ontology a ribonucleoside ribonucleosides CHEBI:18254 ribonucleoside CHEBI:18254 Ribonucleoside KEGG_COMPOUND a ribonucleoside UniProt ribonucleosides ChEBI CHEBI:1083 CHEBI:11394 CHEBI:11567 CHEBI:11568 CHEBI:19259 CHEBI:19560 CHEBI:4421 KEGG:C02269 KEGG:C03216 chebi_ontology 2'-Deoxynucleoside 2'-deoxyribonucleosides 2-Deoxy-D-ribosyl-base Deoxynucleoside a 2'-deoxyribonucleoside CHEBI:18274 2'-deoxyribonucleoside CHEBI:18274 2'-Deoxynucleoside KEGG_COMPOUND 2'-deoxyribonucleosides ChEBI 2-Deoxy-D-ribosyl-base KEGG_COMPOUND Deoxynucleoside KEGG_COMPOUND a 2'-deoxyribonucleoside UniProt That part of DNA or RNA that may be involved in pairing. CHEBI:13873 CHEBI:25598 CHEBI:2995 KEGG:C00701 Wikipedia:Nucleobase chebi_ontology Base nucleobases CHEBI:18282 nucleobase CHEBI:18282 Base KEGG_COMPOUND nucleobases ChEBI An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms. CHEBI:13435 CHEBI:22317 CHEBI:2576 KEGG:C01371 Alkane chebi_ontology Alkan RH alcane alcanes alcano alcanos an alkane CHEBI:18310 alkane CHEBI:18310 Alkane KEGG_COMPOUND Alkan ChEBI RH KEGG_COMPOUND alcane IUPAC alcanes IUPAC alcano IUPAC alcanos IUPAC an alkane UniProt A phosphate ion that is the conjugate base of hydrogenphosphate. CHEBI:14791 CHEBI:45024 CHEBI:7793 KEGG:C00009 PDBeChem:PO4 Wikipedia:Phosphate chebi_ontology Orthophosphate PHOSPHATE ION PO4(3-) Phosphate [PO4](3-) CHEBI:18367 phosphate(3-) CHEBI:18367 Orthophosphate KEGG_COMPOUND PHOSPHATE ION PDBeChem PO4(3-) IUPAC Phosphate KEGG_COMPOUND [PO4](3-) IUPAC chebi_ontology 1-amino-2-naphthol-4-sulfonic acid 1-amino-4-sulfo-2-naphthol 4-amino-3-hydroxynaphthalene-1-sulphonic acid CHEBI:19024 4-amino-3-hydroxynaphthalene-1-sulfonic acid CHEBI:19024 1-amino-2-naphthol-4-sulfonic acid ChemIDplus 1-amino-4-sulfo-2-naphthol ChemIDplus 4-amino-3-hydroxynaphthalene-1-sulphonic acid ChemIDplus A haloalkane that is bromoethane substituted by chlorine at position 2. chebi_ontology 1,2-bromochloroethane 1,2-chlorobromoethane 2-bromo-1-chloroethane 2-bromoethyl chloride 2-chloroethyl bromide beta-chloroethyl bromide ethylene chlorobromide CHEBI:19032 1-bromo-2-chloroethane CHEBI:19032 1,2-bromochloroethane NIST_Chemistry_WebBook 1,2-chlorobromoethane ChemIDplus 2-bromo-1-chloroethane ChemIDplus 2-bromoethyl chloride NIST_Chemistry_WebBook 2-chloroethyl bromide NIST_Chemistry_WebBook beta-chloroethyl bromide NIST_Chemistry_WebBook ethylene chlorobromide ChemIDplus chebi_ontology pyrimidine 2'-deoxyribonucleosides CHEBI:19255 pyrimidine 2'-deoxyribonucleoside CHEBI:19255 pyrimidine 2'-deoxyribonucleosides ChEBI A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups. chebi_ontology 2,5,-bis(ethyleneimine)-1,4-benzoquinone 2,5,-bisethylene-imine-1,4-benzoquinone 2,5-Bisaethyleniminobenzochinon-1,4 2,5-bis(1-aziridinyl)-2,5-cyclohexadiene-1,4-dione 2,5-bis(1-aziridinyl)-p-benzoquinone 2,5-bis(1-aziridynyl)benzoquinone 2,5-bis(aziridino)-1,4-benzoquinone 2,5-bis(aziridino)benzoquinone 2,5-bis(ethyleneimino)-1,4-benzoquinone 2,5-bis-ethyleniminobenzoquinone 2,5-bisethyleneiminebenzoquinone 2,5-di(ethyleneimino)-1,4-benzoquinone 2,5-diaziridinyl-1,4-benzoquinone 3,6-diaziridinyl-1,4-benzoquinone DZQ TW 13 ethylenimine quinone CHEBI:19363 2,5-bis(aziridin-1-yl)-1,4-benzoquinone CHEBI:19363 2,5,-bis(ethyleneimine)-1,4-benzoquinone ChEBI 2,5,-bisethylene-imine-1,4-benzoquinone ChEBI 2,5-Bisaethyleniminobenzochinon-1,4 ChEBI 2,5-bis(1-aziridinyl)-2,5-cyclohexadiene-1,4-dione ChemIDplus 2,5-bis(1-aziridinyl)-p-benzoquinone ChemIDplus 2,5-bis(1-aziridynyl)benzoquinone ChemIDplus 2,5-bis(aziridino)-1,4-benzoquinone ChemIDplus 2,5-bis(aziridino)benzoquinone ChemIDplus 2,5-bis(ethyleneimino)-1,4-benzoquinone ChemIDplus 2,5-bis-ethyleniminobenzoquinone ChemIDplus 2,5-bisethyleneiminebenzoquinone ChemIDplus 2,5-di(ethyleneimino)-1,4-benzoquinone ChemIDplus 2,5-diaziridinyl-1,4-benzoquinone ChemIDplus 3,6-diaziridinyl-1,4-benzoquinone ChEBI DZQ ChEBI TW 13 ChemIDplus ethylenimine quinone ChemIDplus chebi_ontology mitomycin C CHEBI:194095 mitomycin C(1-) CHEBI:194095 mitomycin C UniProt chebi_ontology CHEBI:19508 2-chloroethyl methanesulfonate CHEBI:19508 chebi_ontology CHEBI:19579 2-fluoroethyl methanesulfonate CHEBI:19579 A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen. chebi_ontology 1,2,3,4-tetrahydro-5-bromo-2,4-pyrimidinedione 5-BU 5-BrU 5-bromo-2,4(1H,3H)-pyrimidinedione bromouracil CHEBI:20552 5-bromouracil CHEBI:20552 1,2,3,4-tetrahydro-5-bromo-2,4-pyrimidinedione NIST_Chemistry_WebBook 5-BU ChemIDplus 5-BrU ChemIDplus 5-bromo-2,4(1H,3H)-pyrimidinedione NIST_Chemistry_WebBook bromouracil ChemIDplus A uridine having a bromo substituent at the 5-position. 5-bromouridine chebi_ontology 1-beta-ribofuranosyl-5-bromo-uracil 5-bromo-1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione BrU CHEBI:20553 5-bromouridine CHEBI:20553 5-bromouridine ChEBI 5-bromouridine UniProt 1-beta-ribofuranosyl-5-bromo-uracil ChemIDplus 5-bromo-1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione ChEBI BrU ChEBI Any aminopurine having the amino substituent at the 2-position. 2-aminopurines chebi_ontology CHEBI:20702 2-aminopurines CHEBI:20702 2-aminopurines ChEBI A member of the class of tetraphenes that is tetraphene in which the hydrogens at positions 7 and 12 are replaced by bromomethyl and methyl groups, respectively. chebi_ontology 7-BrMe-12-MeBA 7-bromomethyl-12-methylbenz[a]anthracene 7-bromomethyl-12-methylbenzanthracene CHEBI:20787 7-bromomethyl-12-methyltetraphene CHEBI:20787 7-BrMe-12-MeBA ChEBI 7-bromomethyl-12-methylbenz[a]anthracene ChemIDplus 7-bromomethyl-12-methylbenzanthracene ChemIDplus chebi_ontology ICR 170 N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-1,3-propanediamine dihydrochloride acridine mustard CHEBI:21183 ICR-170 CHEBI:21183 ICR 170 ChemIDplus N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-1,3-propanediamine dihydrochloride ChemIDplus acridine mustard ChemIDplus Patent:US2882209 chebi_ontology 3-(diethylamino)-7-((4-(dimethylamino)phenyl)azo)-5-phenylphenazinium chloride 3-(diethylamino)-7-((p-(dimethylamino)phenyl)azo)-5-phenylphenazinium chloride Janus Green B Janus Green V CHEBI:21184 Janus Green B chloride CHEBI:21184 3-(diethylamino)-7-((4-(dimethylamino)phenyl)azo)-5-phenylphenazinium chloride ChemIDplus 3-(diethylamino)-7-((p-(dimethylamino)phenyl)azo)-5-phenylphenazinium chloride ChemIDplus Janus Green B ChemIDplus Janus Green V ChemIDplus Any N-acylamino acid having L-configuration. chebi_ontology CHEBI:21644 N-acyl-L-amino acid CHEBI:21644 A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond. chebi_ontology N-glycoside N-glycosides N-glycosyl compounds glycosylamines CHEBI:21731 N-glycosyl compound CHEBI:21731 N-glycoside ChEBI N-glycosides ChEBI N-glycosyl compounds ChEBI glycosylamines IUPAC An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position CHEBI:34872 KEGG:C14592 N-Methyl-N'-nitro-N-nitrosoguanidine chebi_ontology 1-Methyl-1-nitroso-3-nitroguanidine 1-Methyl-3-nitro-1-nitrosoguanidine 1-Nitroso-3-nitro-1-methylguanidine MNG MNNG Methylnitronitrosoguanidine N'-Nitro-N-nitroso-N-methylguanidine N-Methyl-N',2-dioxohydrazinecarboximidohydrazide 2-oxide N-Methyl-N-nitroso-N'-nitroguanidine N-Methyl-N-nitrosonitroguanidin N-Nitroso-N-methyl-N'-nitroguanidine CHEBI:21759 N-methyl-N'-nitro-N-nitrosoguanidine CHEBI:21759 N-Methyl-N'-nitro-N-nitrosoguanidine KEGG_COMPOUND 1-Methyl-1-nitroso-3-nitroguanidine ChemIDplus 1-Methyl-3-nitro-1-nitrosoguanidine KEGG_COMPOUND 1-Nitroso-3-nitro-1-methylguanidine ChemIDplus MNG ChemIDplus MNNG ChemIDplus MNNG KEGG_COMPOUND Methylnitronitrosoguanidine KEGG_COMPOUND N'-Nitro-N-nitroso-N-methylguanidine ChemIDplus N-Methyl-N',2-dioxohydrazinecarboximidohydrazide 2-oxide NIST_Chemistry_WebBook N-Methyl-N-nitroso-N'-nitroguanidine ChEBI N-Methyl-N-nitroso-N'-nitroguanidine ChemIDplus N-Methyl-N-nitrosonitroguanidin ChEBI N-Nitroso-N-methyl-N'-nitroguanidine ChemIDplus chebi_ontology CHEBI:22025 S-2-chloroethylcysteine CHEBI:22025 An organosulfur compound having the structure R2S=O or R2C=S=O (R =/= H). CHEBI:35813 sulfoxide chebi_ontology S-oxides sulfoxides CHEBI:22063 sulfoxide CHEBI:22063 sulfoxide ChEBI S-oxides ChEBI sulfoxides ChEBI Compounds with the general formula RNHC(=O)CH3. chebi_ontology CHEBI:22160 acetamides CHEBI:22160 chebi_ontology CHEBI:22213 acridines CHEBI:22213 An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids. acyl group chebi_ontology acyl groups alkanoyl group groupe acyle CHEBI:22221 acyl group CHEBI:22221 acyl group IUPAC acyl groups ChEBI alkanoyl group ChEBI groupe acyle IUPAC chebi_ontology Alkalimetall Alkalimetalle alkali metal metal alcalin metal alcalino metales alcalinos metaux alcalins CHEBI:22314 alkali metal atom CHEBI:22314 Alkalimetall ChEBI Alkalimetalle ChEBI alkali metal ChEBI metal alcalin ChEBI metal alcalino ChEBI metales alcalinos ChEBI metaux alcalins ChEBI Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids. Wikipedia:Alkaloid Alkaloid chebi_ontology Alkaloide alcaloide alcaloides CHEBI:22315 alkaloid CHEBI:22315 Alkaloid ChEBI Alkaloide ChEBI alcaloide ChEBI alcaloides ChEBI A univalent group -CnH2n+1 derived from an alkane by removal of a hydrogen atom from any carbon atom. chebi_ontology groupe alkyle grupo alquilo grupos alquilo CHEBI:22323 alkyl group CHEBI:22323 groupe alkyle IUPAC grupo alquilo IUPAC grupos alquilo IUPAC chebi_ontology aliphatic thioether aliphatic thioethers CHEBI:22327 aliphatic sulfide CHEBI:22327 aliphatic thioether ChEBI aliphatic thioethers ChEBI Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases. chebi_ontology CHEBI:22333 alkylating agent CHEBI:22333 chebi_ontology aminobenzoates CHEBI:22494 aminobenzoate CHEBI:22494 aminobenzoates ChEBI chebi_ontology Aminobenzoesaeure CHEBI:22495 aminobenzoic acid CHEBI:22495 Aminobenzoesaeure ChEBI 4-aminofolic acid chebi_ontology 4-amino-PGA 4-aminopteroylglutamic acid N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid aminopterin CHEBI:22526 4-aminofolic acid CHEBI:22526 4-aminofolic acid ChemIDplus 4-amino-PGA ChemIDplus 4-aminopteroylglutamic acid ChemIDplus N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid ChemIDplus aminopterin ChemIDplus Any purine having at least one amino substituent. chebi_ontology aminopurines CHEBI:22527 aminopurine CHEBI:22527 aminopurines ChEBI A monoatomic or polyatomic species having one or more elementary charges of the electron. Anion anion chebi_ontology Anionen aniones anions CHEBI:22563 anion CHEBI:22563 Anion ChEBI anion ChEBI Anionen ChEBI aniones ChEBI anions IUPAC A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. chebi_ontology antioxidants antioxydant antoxidant CHEBI:22586 antioxidant CHEBI:22586 antioxidants ChEBI antioxydant ChEBI antoxidant ChEBI A substance that destroys or inhibits replication of viruses. chebi_ontology anti-viral agent anti-viral agents antiviral antiviral agents antivirals CHEBI:22587 antiviral agent CHEBI:22587 anti-viral agent ChEBI anti-viral agents ChEBI antiviral ChEBI antiviral agents ChEBI antivirals ChEBI chebi_ontology CHEBI:22681 aziridines CHEBI:22681 A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base). KEGG:C00701 Base base chebi_ontology Base1 Base2 Basen Nucleobase bases CHEBI:22695 base CHEBI:22695 Base ChEBI base ChEBI Base1 KEGG_COMPOUND Base2 KEGG_COMPOUND Basen ChEBI Nucleobase KEGG_COMPOUND bases ChEBI Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives. chebi_ontology CHEBI:22712 benzenes CHEBI:22712 chebi_ontology arenesulfonates CHEBI:22713 arenesulfonate oxoanion CHEBI:22713 arenesulfonates ChEBI A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any benzoic acid. chebi_ontology benzoate anion CHEBI:22718 benzoates CHEBI:22718 benzoate anion ChEBI Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group. chebi_ontology CHEBI:22723 benzoic acids CHEBI:22723 Wikipedia:Benzopyran chebi_ontology benzopyrans CHEBI:22727 benzopyran CHEBI:22727 benzopyrans ChEBI Any quinone resulting from the formal oxidation of catechol, hydroquinone, or their C-substituted derivatives. chebi_ontology CHEBI:22729 benzoquinones CHEBI:22729 chebi_ontology Bn C6H5-CH2- phenylalanine side-chain phenylmethyl CHEBI:22744 benzyl group CHEBI:22744 Bn ChEBI C6H5-CH2- IUPAC phenylalanine side-chain ChEBI phenylmethyl IUPAC Any compound that produces a peak used as reference frequency in the delta chemical shift scale. chebi_ontology NMR chemical shift reference compounds NMR chemical shift standard NMR chemical shift standards NMR internal standard NMR internal standards NMR reference standard NMR reference standards CHEBI:228364 NMR chemical shift reference compound CHEBI:228364 NMR chemical shift reference compounds ChEBI NMR chemical shift standard ChEBI NMR chemical shift standards ChEBI NMR internal standard ChEBI NMR internal standards ChEBI NMR reference standard ChEBI NMR reference standards ChEBI chebi_ontology (BO3)3- BO3(3-) [BO3](3-) borate ion trioxoborate(3-) ion trioxoborate(III) anion CHEBI:22908 borate CHEBI:22908 (BO3)3- ChEBI BO3(3-) IUPAC [BO3](3-) IUPAC borate ion ChEBI trioxoborate(3-) ion ChEBI trioxoborate(III) anion ChEBI Any inorganic anion that is formally derived from boric acid. The term includes polymeric anions containing chains of BO3 structural units sharing one oxygen atom (e.g. di-, tri-, and tetraborates) as well as chains or rings sharing two oxygen atoms (e.g. metaborates). Wikipedia:Borate borate ion chebi_ontology borate anions borate ions CHEBI:22909 borate ion CHEBI:22909 borate ion ChEBI borate anions ChEBI borate ions ChEBI boron molecular entity chebi_ontology boron compounds boron molecular entities CHEBI:22916 boron molecular entity CHEBI:22916 boron molecular entity ChEBI boron compounds ChEBI boron molecular entities ChEBI A compound derived from a hydrocarbon by replacing a hydrogen atom with a bromine atom. chebi_ontology brominated hydrocarbons bromohydrocarbons CHEBI:22926 bromohydrocarbon CHEBI:22926 brominated hydrocarbons ChEBI bromohydrocarbons ChEBI WebElements:Br chebi_ontology 35Br Br Brom brome bromine bromo bromum CHEBI:22927 bromine atom CHEBI:22927 35Br IUPAC Br ChEBI Brom ChEBI brome ChEBI bromine ChEBI bromo ChEBI bromum ChEBI bromine molecular entity chebi_ontology bromine compounds bromine molecular entities CHEBI:22928 bromine molecular entity CHEBI:22928 bromine molecular entity ChEBI bromine compounds ChEBI bromine molecular entities ChEBI Any haloalkane that consists of an alkane substituted by at least one bromine atom. chebi_ontology alkyl bromide alkyl bromides bromoalkanes CHEBI:22929 bromoalkane CHEBI:22929 alkyl bromide ChEBI alkyl bromides ChEBI bromoalkanes ChEBI A diol that is a butanediol or a derivative of a butanediol. chebi_ontology CHEBI:22944 butanediols CHEBI:22944 Any ester of carbamic acid or its N-substituted derivatives. Wikipedia:Carbamate chebi_ontology carbamate esters carbamates CHEBI:23003 carbamate ester CHEBI:23003 carbamate esters ChEBI carbamates ChEBI The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid. chebi_ontology -C(O)NH2 -CONH2 aminocarbonyl carbamyl carbamyl group carboxamide CHEBI:23004 carbamoyl group CHEBI:23004 -C(O)NH2 ChEBI -CONH2 IUPAC aminocarbonyl IUPAC carbamyl ChEBI carbamyl group ChEBI carboxamide IUPAC carbonyl group chebi_ontology >C=O CHEBI:23019 carbonyl group CHEBI:23019 carbonyl group ChEBI carbonyl group UniProt >C=O IUPAC A substance intended to sterilize any organism. Wikipedia:Chemosterilant chebi_ontology chemosterilants CHEBI:23092 chemosterilant CHEBI:23092 chemosterilants ChEBI chebi_ontology chloride salts chlorides CHEBI:23114 chloride salt CHEBI:23114 chloride salts ChEBI chlorides ChEBI WebElements:Cl chebi_ontology 17Cl Chlor Cl chlore chlorine chlorum cloro CHEBI:23116 chlorine atom CHEBI:23116 17Cl IUPAC Chlor ChEBI Cl IUPAC chlore ChEBI chlorine ChEBI chlorum ChEBI cloro ChEBI A halogen molecular entity containing one or more atoms of chlorine. chebi_ontology CHEBI:23117 chlorine molecular entity CHEBI:23117 Any haloalkane that consists of an alkane substituted by at least one chloro group. chloroalkane chebi_ontology alkyl chloride alkyl chlorides chloroalkanes CHEBI:23128 chloroalkane CHEBI:23128 chloroalkane ChEBI alkyl chloride ChEBI alkyl chlorides ChEBI chloroalkanes ChEBI chebi_ontology CHEBI:23239 chromopeptide CHEBI:23239 An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group). Wikipedia:Cofactor_(biochemistry) cofactor chebi_ontology CHEBI:23357 cofactor CHEBI:23357 cofactor IUPAC An alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum. DrugBank:DB01394 HMDB:HMDB0015466 LINCS:LSM-6449 chebi_ontology CHEBI:23359 colchicine CHEBI:23359 Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. chebi_ontology entidad molecular entidades moleculares entite moleculaire molecular entities molekulare Entitaet CHEBI:23367 molecular entity CHEBI:23367 entidad molecular IUPAC entidades moleculares IUPAC entite moleculaire IUPAC molecular entities IUPAC molekulare Entitaet ChEBI copper molecular entity chebi_ontology copper compounds copper molecular entities CHEBI:23377 copper molecular entity CHEBI:23377 copper molecular entity ChEBI copper compounds ChEBI copper molecular entities ChEBI chebi_ontology Cu cation copper cations CHEBI:23378 copper cation CHEBI:23378 Cu cation UniProt copper cations ChEBI A metal sulfate compound having copper(2+) as the metal ion. KEGG:C18713 PPDB:178 Wikipedia:Copper(II)_sulfate Copper(II) sulfate chebi_ontology CuSO4 Cupric sulfate copper sulfate cupric sulfate anhydrous CHEBI:23414 copper(II) sulfate CHEBI:23414 Copper(II) sulfate KEGG_COMPOUND CuSO4 IUPAC Cupric sulfate ChemIDplus copper sulfate ChemIDplus cupric sulfate anhydrous ChemIDplus An amino acid derivative resulting from reaction of cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of cysteine by a heteroatom. The definition normally excludes peptides containing cysteine residues. CHEBI:25309 cysteine derivative chebi_ontology cysteine derivatives CHEBI:23509 cysteine derivative CHEBI:23509 cysteine derivative ChEBI cysteine derivatives ChEBI chebi_ontology deoxyribonucleosides CHEBI:23636 deoxyribonucleoside CHEBI:23636 deoxyribonucleosides ChEBI chebi_ontology 1,1'-bi[ethylene oxide] 1,2:3,4-butadiene diepoxide 1,2:3,4-dianhydrothreitol 1,2:3,4-diepoxybutane 1,3-butadiene diepoxide Butadiendioxyd DEB bioxirane butadiene diepoxide butadiene dioxide butane diepoxide dioxybutadiene CHEBI:23704 diepoxybutane CHEBI:23704 1,1'-bi[ethylene oxide] NIST_Chemistry_WebBook 1,2:3,4-butadiene diepoxide ChemIDplus 1,2:3,4-dianhydrothreitol NIST_Chemistry_WebBook 1,2:3,4-diepoxybutane ChemIDplus 1,3-butadiene diepoxide NIST_Chemistry_WebBook Butadiendioxyd ChemIDplus DEB NIST_Chemistry_WebBook bioxirane NIST_Chemistry_WebBook butadiene diepoxide NIST_Chemistry_WebBook butadiene dioxide NIST_Chemistry_WebBook butane diepoxide NIST_Chemistry_WebBook dioxybutadiene ChemIDplus chebi_ontology 1,2,7,8-Diepoxyoctane 1,2-Epoxy-7,8-epoxyoctane 1,7-Octadiene diepoxide 2,2'-(1,4-Butanediyl)bisoxirane CHEBI:23705 1,2:7,8-diepoxyoctane CHEBI:23705 1,2,7,8-Diepoxyoctane ChemIDplus 1,2-Epoxy-7,8-epoxyoctane ChemIDplus 1,7-Octadiene diepoxide ChemIDplus 2,2'-(1,4-Butanediyl)bisoxirane ChemIDplus A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols. Wikipedia:Diol chebi_ontology CHEBI:23824 diol CHEBI:23824 Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances. chebi_ontology drugs medicine CHEBI:23888 drug CHEBI:23888 drugs ChEBI medicine ChEBI chebi_ontology monoatomic anions CHEBI:23905 monoatomic anion CHEBI:23905 monoatomic anions ChEBI chebi_ontology monoatomic cations CHEBI:23906 monoatomic cation CHEBI:23906 monoatomic cations ChEBI A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. chebi_ontology enzyme inhibitors inhibidor enzimatico inhibidores enzimaticos inhibiteur enzymatique inhibiteurs enzymatiques CHEBI:23924 enzyme inhibitor CHEBI:23924 enzyme inhibitors ChEBI inhibidor enzimatico ChEBI inhibidores enzimaticos ChEBI inhibiteur enzymatique ChEBI inhibiteurs enzymatiques ChEBI A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol. KEGG:C19239 Wikipedia:Ethyl_methanesulfonate chebi_ontology EMS ethyl mesylate ethyl methanesulphonate methylsulfonic acid ethyl ester methylsulfonic acid, ethyl ester CHEBI:23994 ethyl methanesulfonate CHEBI:23994 EMS ChemIDplus ethyl mesylate ChemIDplus ethyl methanesulphonate ChemIDplus methylsulfonic acid ethyl ester ChemIDplus methylsulfonic acid, ethyl ester ChemIDplus A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups. KEGG:C19178 Wikipedia:ENU chebi_ontology 1-(Aminocarbonyl)-1-ethyl-2-oxohydrazine 1-Ethyl-1-nitrosourea Aethylnitroso-harnstoff ENU Ethyl nitrosourea N-Ethyl-N-nitroso carbamide N-Ethyl-N-nitroso-urea N-Ethylnitrosourea NEU CHEBI:23995 N-ethyl-N-nitrosourea CHEBI:23995 Ethyl nitrosourea ChemIDplus N-Ethyl-N-nitroso carbamide ChemIDplus N-Ethyl-N-nitroso-urea ChemIDplus N-Ethylnitrosourea ChemIDplus NEU NIST_Chemistry_WebBook 1-(Aminocarbonyl)-1-ethyl-2-oxohydrazine NIST_Chemistry_WebBook 1-Ethyl-1-nitrosourea ChemIDplus Aethylnitroso-harnstoff ChemIDplus ENU ChemIDplus An aliphatic sulfide in which the sulfur atom is bonded to at least one ethyl group. chebi_ontology ethyl sulfides CHEBI:23996 ethyl sulfide CHEBI:23996 ethyl sulfides ChEBI chebi_ontology fluoride salts fluorides CHEBI:24060 fluoride salt CHEBI:24060 fluoride salts ChEBI fluorides ChEBI WebElements:F chebi_ontology 9F F Fluor fluor fluorine fluorum CHEBI:24061 fluorine atom CHEBI:24061 9F IUPAC F IUPAC Fluor ChemIDplus fluor ChEBI fluorine ChEBI fluorum ChEBI fluorine molecular entity chebi_ontology fluorine compounds fluorine molecular entities CHEBI:24062 fluorine molecular entity CHEBI:24062 fluorine molecular entity ChEBI fluorine compounds ChEBI fluorine molecular entities ChEBI An amino acid derivative resulting from reaction of glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing glutamic acid residues. chebi_ontology CHEBI:24315 glutamic acid derivative CHEBI:24315 An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class. chebi_ontology glutamine family amino acids CHEBI:24318 glutamine family amino acid CHEBI:24318 glutamine family amino acids ChEBI An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2). Wikipedia:Glutamine_synthetase chebi_ontology EC 6.3.1.2 (glutamate--ammonia ligase) inhibitors EC 6.3.1.2 inhibitor EC 6.3.1.2 inhibitors L-glutamate:ammonia ligase (ADP-forming) inhibitor L-glutamate:ammonia ligase (ADP-forming) inhibitors L-glutamine synthetase inhibitor L-glutamine synthetase inhibitors glutamate--ammonia ligase (EC 6.3.1.2) inhibitor glutamate--ammonia ligase (EC 6.3.1.2) inhibitors glutamate--ammonia ligase inhibitor glutamate--ammonia ligase inhibitors glutamine synthetase inhibitor glutamine synthetase inhibitors glutamylhydroxamic synthetase inhibitor glutamylhydroxamic synthetase inhibitors CHEBI:24319 EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor CHEBI:24319 EC 6.3.1.2 (glutamate--ammonia ligase) inhibitors ChEBI EC 6.3.1.2 inhibitor ChEBI EC 6.3.1.2 inhibitors ChEBI L-glutamate:ammonia ligase (ADP-forming) inhibitor ChEBI L-glutamate:ammonia ligase (ADP-forming) inhibitors ChEBI L-glutamine synthetase inhibitor ChEBI L-glutamine synthetase inhibitors ChEBI glutamate--ammonia ligase (EC 6.3.1.2) inhibitor ChEBI glutamate--ammonia ligase (EC 6.3.1.2) inhibitors ChEBI glutamate--ammonia ligase inhibitor ChEBI glutamate--ammonia ligase inhibitors ChEBI glutamine synthetase inhibitor ChEBI glutamine synthetase inhibitors ChEBI glutamylhydroxamic synthetase inhibitor ChEBI glutamylhydroxamic synthetase inhibitors ChEBI A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively. chebi_ontology O-glycoside O-glycosides glycosides CHEBI:24400 glycoside CHEBI:24400 O-glycoside ChEBI O-glycosides ChEBI glycosides ChEBI A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. chemical entity chebi_ontology CHEBI:24431 chemical entity CHEBI:24431 chemical entity UniProt A role played by the molecular entity or part thereof within a biological context. chebi_ontology biological function CHEBI:24432 biological role CHEBI:24432 biological function ChEBI A defined linked collection of atoms or a single atom within a molecular entity. chebi_ontology Gruppe Rest groupe grupo grupos CHEBI:24433 group CHEBI:24433 Gruppe ChEBI Rest ChEBI groupe IUPAC grupo IUPAC grupos IUPAC Any organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas. chebi_ontology CHEBI:24436 guanidines CHEBI:24436 A halohydrocarbon that is an alkane in which at least one hydrogen atom has been replaced by with a halogen atom. chebi_ontology alkyl halide alkyl halides haloalkanes CHEBI:24469 haloalkane CHEBI:24469 alkyl halide ChEBI alkyl halides ChEBI haloalkanes ChEBI halogen molecular entity chebi_ontology halogen compounds halogen molecular entities CHEBI:24471 halogen molecular entity CHEBI:24471 halogen molecular entity ChEBI halogen compounds ChEBI halogen molecular entities ChEBI A compound derived from a hydrocarbon by replacing a hydrogen atom with a halogen atom. chebi_ontology halogenated hydrocarbons halohydrocarbons CHEBI:24472 halohydrocarbon CHEBI:24472 halogenated hydrocarbons ChEBI halohydrocarbons ChEBI chebi_ontology Halogene group 17 elements group VII elements halogene halogenes halogeno halogenos CHEBI:24473 halogen CHEBI:24473 Halogene ChEBI group 17 elements ChEBI group VII elements ChEBI halogene ChEBI halogenes ChEBI halogeno ChEBI halogenos ChEBI A cyclic compound having as ring members atoms of carbon and at least of one other element. chebi_ontology organic heterocycle organic heterocyclic compounds CHEBI:24532 organic heterocyclic compound CHEBI:24532 organic heterocycle ChEBI organic heterocyclic compounds ChEBI LINCS:LSM-3492 Patent:DE1240870 Patent:US3424752 Wikipedia:Altretamine chebi_ontology 2,4,6-tris(dimethylamino)-1,3,5-triazine 2,4,6-tris(dimethylamino)-s-triazine HMM CHEBI:24564 hexamethylmelamine CHEBI:24564 2,4,6-tris(dimethylamino)-1,3,5-triazine ChemIDplus 2,4,6-tris(dimethylamino)-s-triazine NIST_Chemistry_WebBook HMM ChemIDplus KEGG:C19250 hexamethylphosphoric triamide chebi_ontology HEMPA HMPA HMPT HMPTA Hexamethylphosphoramid Hexamethylphosphorsaeuretriamid hexamethylorthophosphoric triamide hexamethylphosphoramide hexamethylphosphoric acid triamide phosphoric acid hexamethyltriamide phosphoric hexamethyltriamide phosphoric tris(dimethylamide) CHEBI:24565 hexamethylphosphoric triamide CHEBI:24565 hexamethylphosphoric triamide ChemIDplus HEMPA NIST_Chemistry_WebBook HMPA ChemIDplus HMPA KEGG_COMPOUND HMPT ChemIDplus HMPTA ChemIDplus Hexamethylphosphoramid ChEBI Hexamethylphosphorsaeuretriamid ChEBI hexamethylorthophosphoric triamide NIST_Chemistry_WebBook hexamethylphosphoramide ChEBI hexamethylphosphoric acid triamide ChemIDplus phosphoric acid hexamethyltriamide NIST_Chemistry_WebBook phosphoric hexamethyltriamide NIST_Chemistry_WebBook phosphoric tris(dimethylamide) NIST_Chemistry_WebBook A methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel. KEGG:C19432 chebi_ontology N,N-diethyl-2-{[4-(hydroxymethyl)-10-oxo-10H-dibenzo[b,e]thiopyran-1-yl]amino}ethanaminium methanesulfonate N-[2-(diethylamino)ethyl]-4-methoxy-9-oxoxanthene-1-amine monomethanesulfonate hycanthone methanesulfonate hycanthone methanesulphonate hycanthone monomesylate hycanthone monomethanesulfonate hycanthone monomethanesulphonate CHEBI:24624 hycanthone mesylate CHEBI:24624 N,N-diethyl-2-{[4-(hydroxymethyl)-10-oxo-10H-dibenzo[b,e]thiopyran-1-yl]amino}ethanaminium methanesulfonate IUPAC N-[2-(diethylamino)ethyl]-4-methoxy-9-oxoxanthene-1-amine monomethanesulfonate ChEBI hycanthone methanesulfonate ChemIDplus hycanthone methanesulphonate ChemIDplus hycanthone monomesylate ChEBI hycanthone monomethanesulfonate ChemIDplus hycanthone monomethanesulphonate ChemIDplus A compound consisting of carbon and hydrogen only. chebi_ontology Kohlenwasserstoff Kohlenwasserstoffe hidrocarburo hidrocarburos hydrocarbure CHEBI:24632 hydrocarbon CHEBI:24632 Kohlenwasserstoff ChEBI Kohlenwasserstoffe ChEBI hidrocarburo IUPAC hidrocarburos IUPAC hydrocarbure IUPAC Benzenediols that have the hydroxy substituents in the 1- and 4-positions. CHEBI:134188 chebi_ontology 1,4-benzoquinols a 1,4-benzoquinol a quinol benzene-1,4-diols CHEBI:24646 hydroquinones CHEBI:24646 1,4-benzoquinols ChEBI a 1,4-benzoquinol ChEBI a quinol UniProt benzene-1,4-diols ChEBI Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)). chebi_ontology CHEBI:24651 hydroxides CHEBI:24651 A member of the class of flavanones that consists of flavanone with one or more hydroxy substituents. hydroxyflavanone chebi_ontology hydroxyflavanones CHEBI:24697 hydroxyflavanone CHEBI:24697 hydroxyflavanone ChEBI hydroxyflavanones ChEBI Any member of the class of naphthalenes that is naphthalene carrying one or more hydroxy groups. chebi_ontology CHEBI:24727 hydroxynaphthalene CHEBI:24727 A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). chebi_ontology oxacids oxiacids oxo acid oxy-acids oxyacids CHEBI:24833 oxoacid CHEBI:24833 oxacids ChEBI oxiacids ChEBI oxo acid ChEBI oxy-acids ChEBI oxyacids ChEBI chebi_ontology inorganic anions CHEBI:24834 inorganic anion CHEBI:24834 inorganic anions ChEBI A molecular entity that contains no carbon. chebi_ontology anorganische Verbindungen inorganic compounds inorganic entity inorganic molecular entities inorganics CHEBI:24835 inorganic molecular entity CHEBI:24835 anorganische Verbindungen ChEBI inorganic compounds ChEBI inorganic entity ChEBI inorganic molecular entities ChEBI inorganics ChEBI chebi_ontology inorganic oxides CHEBI:24836 inorganic oxide CHEBI:24836 inorganic oxides ChEBI chebi_ontology anorganisches Salz inorganic salts CHEBI:24839 inorganic salt CHEBI:24839 anorganisches Salz ChEBI inorganic salts ChEBI chebi_ontology inorganic sulfate salts inorganic sulfates CHEBI:24840 inorganic sulfate salt CHEBI:24840 inorganic sulfate salts ChEBI inorganic sulfates ChEBI Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects. Wikipedia:Insecticide chebi_ontology insecticides CHEBI:24852 insecticide CHEBI:24852 insecticides ChEBI A role played by a chemical agent which exhibits the capability of occupying space between DNA base pairs due to particular properties in size, shape and charge. Intercalation of chemical compounds in DNA helix can result in replication errors (shift, mutation) or DNA damages. chebi_ontology agente intercalante intercalating agent intercalating agents intercalating ligands intercalators CHEBI:24853 intercalator CHEBI:24853 agente intercalante ChEBI intercalating agent ChEBI intercalating agents ChEBI intercalating ligands ChEBI intercalators ChEBI Chemical element with atomic number 53. WebElements:I chebi_ontology 53I I Iod J Jod iode iodine iodium yodo CHEBI:24859 iodine atom CHEBI:24859 53I IUPAC I ChEBI Iod ChEBI J ChEBI Jod ChEBI iode ChEBI iodine ChEBI iodium ChEBI yodo ChEBI A salt is an assembly of cations and anions. chebi_ontology Salz Salze ionic compound ionic compounds sal sales salts sel sels CHEBI:24866 salt CHEBI:24866 Salz ChEBI Salze ChEBI ionic compound ChEBI ionic compounds ChEBI sal ChEBI sales ChEBI salts ChEBI sel ChEBI sels ChEBI chebi_ontology monoatomic ions CHEBI:24867 monoatomic ion CHEBI:24867 monoatomic ions ChEBI chebi_ontology organic salts organisches Salz CHEBI:24868 organic salt CHEBI:24868 organic salts ChEBI organisches Salz ChEBI A molecular entity having a net electric charge. Ion ion chebi_ontology Ionen iones ions CHEBI:24870 ion CHEBI:24870 Ion ChEBI ion ChEBI Ionen ChEBI iones ChEBI ions ChEBI Any alkaloid that has a structure based on an isoquinoline nucleus. They are derived from the amino acids like tyrosine and phenylalanine. chebi_ontology isoquinoline alkaloids CHEBI:24921 isoquinoline alkaloid CHEBI:24921 isoquinoline alkaloids ChEBI Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. CHEBI:26619 CHEBI:35220 chebi_ontology metabolites primary metabolites secondary metabolites CHEBI:25212 metabolite CHEBI:25212 metabolites ChEBI primary metabolites ChEBI secondary metabolites ChEBI chebi_ontology a metal cation metal cations CHEBI:25213 metal cation CHEBI:25213 a metal cation UniProt metal cations ChEBI An organosulfonic ester resulting from the formal condensation of methanesulfonic acid with the hydroxy group of an alcohol, phenol, heteroarenol, or enol. chebi_ontology mesylate ester mesylate esters methanesulfonic acid esters CHEBI:25223 methanesulfonate ester CHEBI:25223 mesylate ester ChEBI mesylate esters ChEBI methanesulfonic acid esters ChEBI A 1,1-diunsubstituted alkanesulfonate that is the conjugate base of methanesulfonic acid. MetaCyc:CPD-3746 methanesulfonate chebi_ontology methylsulfonate CHEBI:25224 methanesulfonate CHEBI:25224 methanesulfonate UniProt methylsulfonate UM-BBD chebi_ontology CHEBI:25234 1-methoxy-N-nitrosodiethylamine CHEBI:25234 A member of the class of flavanones that consists of flavanone with one or more methoxy substituents. chebi_ontology methoxyflavanones CHEBI:25240 methoxyflavanone CHEBI:25240 methoxyflavanones ChEBI A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol. KEGG:C19181 MetaCyc:CPD-7038 Wikipedia:Methyl_methanesulfonate chebi_ontology CB1540 MMS Methanesulfonic acid methyl ester Methyl mesylate as-Dimethyl sulfite CHEBI:25255 methyl methanesulfonate CHEBI:25255 CB1540 ChEBI MMS ChemIDplus MMS KEGG_COMPOUND Methanesulfonic acid methyl ester ChemIDplus Methyl mesylate ChemIDplus as-Dimethyl sulfite ChemIDplus chebi_ontology methylxanthines CHEBI:25348 methylxanthine CHEBI:25348 methylxanthines ChEBI A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. Wikipedia:Mitomycin chebi_ontology mitomycins CHEBI:25357 mitomycin CHEBI:25357 mitomycins ChEBI Any polyatomic entity that is an electrically neutral entity consisting of more than one atom. molecule chebi_ontology Molekuel molecula molecules neutral molecular compounds CHEBI:25367 molecule CHEBI:25367 molecule IUPAC Molekuel ChEBI molecula IUPAC molecules IUPAC neutral molecular compounds IUPAC An oxoacid containing a single carboxy group. chebi_ontology monocarboxylic acids CHEBI:25384 monocarboxylic acid CHEBI:25384 monocarboxylic acids ChEBI Any hydroxynaphthalene derivative that has a single hydroxy substituent. chebi_ontology CHEBI:25392 naphthols CHEBI:25392 chebi_ontology monoatomic monocations monovalent inorganic cations CHEBI:25414 monoatomic monocation CHEBI:25414 monoatomic monocations ChEBI monovalent inorganic cations ChEBI An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention. KEGG:C19164 Wikipedia:Sulfur_mustard bis(2-chloroethyl) sulfide chebi_ontology 1,1'-thiobis(2-chloroethane) 1-chloro-2-[(2-chloroethyl)thio]ethane Iprit Lost Mustard gas Senfgas Yperite bis(2-chloroethyl) sulphide bis(2-chloroethyl)sulfane mustard gas sulfur mustard CHEBI:25434 bis(2-chloroethyl) sulfide CHEBI:25434 bis(2-chloroethyl) sulfide ChemIDplus 1,1'-thiobis(2-chloroethane) NIST_Chemistry_WebBook 1-chloro-2-[(2-chloroethyl)thio]ethane IUPAC Iprit KEGG_COMPOUND Lost NIST_Chemistry_WebBook Mustard gas KEGG_COMPOUND Senfgas NIST_Chemistry_WebBook Yperite NIST_Chemistry_WebBook bis(2-chloroethyl) sulphide NIST_Chemistry_WebBook bis(2-chloroethyl)sulfane IUPAC mustard gas ChemIDplus sulfur mustard ChemIDplus An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution. Wikipedia:Mutagen chebi_ontology mutagene mutagenes mutagenic agent mutageno mutagenos mutagens CHEBI:25435 mutagen CHEBI:25435 mutagene ChEBI mutagenes ChEBI mutagenic agent ChEBI mutageno ChEBI mutagenos ChEBI mutagens ChEBI Any benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings. chebi_ontology CHEBI:25477 naphthalenes CHEBI:25477 A substance used to destroy pests of the phylum Nematoda (roundworms). Wikipedia:Nematicide chebi_ontology nematicides nematocide nematocides CHEBI:25491 nematicide CHEBI:25491 nematicides ChEBI nematocide ChEBI nematocides ChEBI An endogenous compound that is used to transmit information across the synapse between a neuron and another cell. Wikipedia:Neurotransmitter chebi_ontology neurotransmitters CHEBI:25512 neurotransmitter CHEBI:25512 neurotransmitters ChEBI WebElements:N chebi_ontology 7N N Stickstoff azote nitrogen nitrogeno CHEBI:25555 nitrogen atom CHEBI:25555 7N IUPAC N IUPAC Stickstoff ChEBI azote IUPAC nitrogen ChEBI nitrogeno ChEBI chebi_ontology Nichtmetall Nichtmetalle no metal no metales non-metal non-metaux nonmetal nonmetals CHEBI:25585 nonmetal atom CHEBI:25585 Nichtmetall ChEBI Nichtmetalle ChEBI no metal ChEBI no metales ChEBI non-metal ChEBI non-metaux ChEBI nonmetal ChEBI nonmetals ChEBI chebi_ontology organic heteromonocyclic compounds CHEBI:25693 organic heteromonocyclic compound CHEBI:25693 organic heteromonocyclic compounds ChEBI Any organic ion with a net negative charge. chebi_ontology organic anions CHEBI:25696 organic anion CHEBI:25696 organic anions ChEBI Any organic ion with a net positive charge. chebi_ontology organic cations CHEBI:25697 organic cation CHEBI:25697 organic cations ChEBI An organooxygen compound with formula ROR, where R is not hydrogen. chebi_ontology ethers CHEBI:25698 ether CHEBI:25698 ethers ChEBI chebi_ontology organic ions CHEBI:25699 organic ion CHEBI:25699 organic ions ChEBI Compounds of the general formula SO3HOR where R is an organyl group chebi_ontology organic sulfates CHEBI:25704 organic sulfate CHEBI:25704 organic sulfates ChEBI An oxide is a chemical compound of oxygen with other chemical elements. oxide chebi_ontology oxides CHEBI:25741 oxide CHEBI:25741 oxide ChEBI oxides ChEBI KEGG:C00007 WebElements:O chebi_ontology 8O O Sauerstoff oxigeno oxygen oxygene CHEBI:25805 oxygen atom CHEBI:25805 8O IUPAC O IUPAC Sauerstoff ChEBI oxigeno ChEBI oxygen ChEBI oxygene ChEBI oxygen molecular entity chebi_ontology oxygen molecular entities CHEBI:25806 oxygen molecular entity CHEBI:25806 oxygen molecular entity ChEBI oxygen molecular entities ChEBI chebi_ontology oxopurines CHEBI:25810 oxopurine CHEBI:25810 oxopurines ChEBI chebi_ontology CHEBI:25813 p-N,N-bis(2-chloroethyl)aminophenylvaleric acid CHEBI:25813 chebi_ontology CHEBI:25814 p-N,N-bis(2-chloroethyl)amino-D-phenylalanine CHEBI:25814 chebi_ontology CHEBI:25816 p-N,N-bis(2-chloroethyl)amino-L-phenylalanine CHEBI:25816 chebi_ontology 4-(bis(2-chloroethyl)amino)benzeneethanamine CB 3034 p-(bis(2-chloroethyl)amino)phenethylamine p-N,N-di-(2-chloroethyl)aminophenylethylamine CHEBI:25818 4-(2-aminoethyl)-N,N-bis(2-chloroethyl)aniline CHEBI:25818 4-(bis(2-chloroethyl)amino)benzeneethanamine ChemIDplus CB 3034 ChemIDplus p-(bis(2-chloroethyl)amino)phenethylamine ChemIDplus p-N,N-di-(2-chloroethyl)aminophenylethylamine ChemIDplus chebi_ontology CHEBI:25829 p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine CHEBI:25829 A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring. chebi_ontology p-quinone para-quinones CHEBI:25830 p-quinones CHEBI:25830 p-quinone ChEBI para-quinones ChEBI A chemically diverse class of peptides that exhibit antimicrobial properties. MetaCyc:Peptide-Antibiotics chebi_ontology peptide antibiotics CHEBI:25903 peptide antibiotic CHEBI:25903 peptide antibiotics ChEBI Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests. Wikipedia:Pesticide chebi_ontology Pestizid Pestizide pesticides CHEBI:25944 pesticide CHEBI:25944 Pestizid ChEBI Pestizide ChEBI pesticides ChEBI An amino acid derivative resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of phenylalanine by a heteroatom. The definition normally excludes peptides containing phenylalanine residues. chebi_ontology CHEBI:25985 phenylalanine derivative CHEBI:25985 Any organic aromatic compound with a structure based on a phenylpropane skeleton. The class includes naturally occurring phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules as well as their semi-synthetic and synthetic analogues. Phenylpropanoids are also precursors of lignin. Wikipedia:Phenylpropanoid chebi_ontology phenylpropanoids CHEBI:26004 phenylpropanoid CHEBI:26004 phenylpropanoids ChEBI A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom. HMDB:HMDB0002142 KEGG:C00009 KEGG:D05467 KNApSAcK:C00007408 Wikipedia:Phosphoric_Acid Phosphoric acid phosphoric acid chebi_ontology H3PO4 Orthophosphoric acid Phosphate Phosphorsaeure Phosphorsaeureloesungen [PO(OH)3] acide phosphorique acidum phosphoricum orthophosphoric acid CHEBI:26078 phosphoric acid CHEBI:26078 Phosphoric acid KEGG_COMPOUND phosphoric acid IUPAC H3PO4 IUPAC Orthophosphoric acid KEGG_COMPOUND Phosphate KEGG_COMPOUND Phosphorsaeure ChEBI Phosphorsaeureloesungen ChEBI [PO(OH)3] IUPAC acide phosphorique ChEBI acidum phosphoricum ChEBI orthophosphoric acid NIST_Chemistry_WebBook chebi_ontology phosphorus molecular entities CHEBI:26082 phosphorus molecular entity CHEBI:26082 phosphorus molecular entities ChEBI Any amino acid whose side chain is capable of forming one or more hydrogen bonds. CHEBI:8283 MetaCyc:Polar-amino-acids polar amino acid chebi_ontology polar amino acids polar amino-acid polar amino-acids CHEBI:26167 polar amino acid CHEBI:26167 polar amino acid ChEBI polar amino acids ChEBI polar amino-acid ChEBI polar amino-acids ChEBI A compound that contains two or more hydroxy groups. chebi_ontology polyols CHEBI:26191 polyol CHEBI:26191 polyols ChEBI Derivatives of oxoacids RnE(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. In organic chemistry an unspecified amidine is commonly a carboxamidine. amidine chebi_ontology Amidines amidines CHEBI:2634 amidine CHEBI:2634 amidine IUPAC Amidines KEGG_COMPOUND amidines ChEBI chebi_ontology CHEBI:26373 pteridines CHEBI:26373 chebi_ontology CHEBI:26375 pterins CHEBI:26375 chebi_ontology purine alkaloids CHEBI:26385 purine alkaloid CHEBI:26385 purine alkaloids ChEBI A nucleobase whose skeleton is derived from purine. KEGG:C15587 purine nucleobase chebi_ontology a purine nucleobase purine bases purine nucleobases CHEBI:26386 purine nucleobase CHEBI:26386 purine nucleobase ChEBI a purine nucleobase UniProt purine bases ChEBI purine nucleobases ChEBI A class of imidazopyrimidines that consists of purine and its substituted derivatives. CHEBI:13678 chebi_ontology CHEBI:26401 purines CHEBI:26401 A nucleobase whose skeleton is derived from pyrimidine. pyrimidine nucleobase chebi_ontology a pyrimidine nucleobase pyrimidine bases pyrimidine nucleobases CHEBI:26432 pyrimidine nucleobase CHEBI:26432 pyrimidine nucleobase ChEBI a pyrimidine nucleobase UniProt pyrimidine bases ChEBI pyrimidine nucleobases ChEBI KEGG:C03169 chebi_ontology N-D-Ribosylpyrimidine pyrimidine nucleosides CHEBI:26440 pyrimidine nucleoside CHEBI:26440 N-D-Ribosylpyrimidine KEGG_COMPOUND pyrimidine nucleosides ChEBI chebi_ontology Chinhydron green hydroquinone p-benzoquinhydrone p-benzoquinone--hydroquinone compound (1:1) CHEBI:26491 quinhydrone CHEBI:26491 Chinhydron ChemIDplus green hydroquinone NIST_Chemistry_WebBook p-benzoquinhydrone ChemIDplus p-benzoquinone--hydroquinone compound (1:1) NIST_Chemistry_WebBook A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring. chebi_ontology CHEBI:26513 quinolines CHEBI:26513 rhamnosylglucoside chebi_ontology rhamnosylglucosides CHEBI:26548 rhamnosylglucoside CHEBI:26548 rhamnosylglucoside ChEBI rhamnosylglucosides ChEBI rutinoside chebi_ontology rutinosides CHEBI:26587 rutinoside CHEBI:26587 rutinoside ChEBI rutinosides ChEBI Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure. chebi_ontology s-triazines CHEBI:26588 1,3,5-triazines CHEBI:26588 s-triazines ChEBI Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess. saturated fatty acid chebi_ontology SFA SFAs saturated fatty acids CHEBI:26607 saturated fatty acid CHEBI:26607 saturated fatty acid ChEBI SFA ChEBI SFAs ChEBI saturated fatty acids ChEBI An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid. chebi_ontology SCFA SCFAs short-chain fatty acids CHEBI:26666 short-chain fatty acid CHEBI:26666 SCFA ChEBI SCFAs ChEBI short-chain fatty acids ChEBI KEGG:C01330 WebElements:Na chebi_ontology 11Na Na Natrium natrium sodio sodium CHEBI:26708 sodium atom CHEBI:26708 11Na IUPAC Na IUPAC Natrium ChemIDplus natrium IUPAC sodio ChemIDplus sodium ChEBI An inorganic sodium salt having hydrogensulfite as the counterion. DrugBank:DB14015 FooDB:FDB015420 KEGG:D02059 Wikipedia:Sodium_bisulfite chebi_ontology E 222 E222 NaHSO3 Natriumbisulfit Natriumhydrogensulfit hydrogen sulfite sodium primaeres Natriumsulfit saures Natriumsulfit sodium bisulfite sodium bisulphite sodium hydrogen sulfite sulfurous acid monosodium salt sulfurous acid sodium salt sulfurous acid, monosodium salt sulfurous acid, sodium salt (1:1) CHEBI:26709 sodium hydrogensulfite CHEBI:26709 E 222 ChEBI E222 ChEBI NaHSO3 ChEBI NaHSO3 IUPAC Natriumbisulfit ChEBI Natriumhydrogensulfit ChEBI hydrogen sulfite sodium ChEBI primaeres Natriumsulfit ChEBI saures Natriumsulfit ChEBI sodium bisulfite ChemIDplus sodium bisulphite ChemIDplus sodium hydrogen sulfite ChemIDplus sulfurous acid monosodium salt ChEBI sulfurous acid sodium salt ChEBI sulfurous acid, monosodium salt ChEBI sulfurous acid, sodium salt (1:1) ChEBI chebi_ontology sodium compounds sodium molecular entities CHEBI:26712 sodium molecular entity CHEBI:26712 sodium compounds ChEBI sodium molecular entities ChEBI Any alkali metal salt having sodium(1+) as the cation. chebi_ontology Natriumsalz Natriumsalze sodium salts CHEBI:26714 sodium salt CHEBI:26714 Natriumsalz ChEBI Natriumsalze ChEBI sodium salts ChEBI chebi_ontology CHEBI:26800 styrylquinoline CHEBI:26800 An ester of an alcohol and sulfuric acid. chebi_ontology sulfate ester sulfuric acid ester sulfuric acid esters CHEBI:26819 sulfuric ester CHEBI:26819 sulfate ester ChEBI sulfuric acid ester ChEBI sulfuric acid esters ChEBI Salts and esters of sulfuric acid sulfates chebi_ontology sulfuric acid derivative sulphates CHEBI:26820 sulfates CHEBI:26820 sulfates ChEBI sulfuric acid derivative ChEBI sulphates ChEBI Any sulfur molecular entity that involves either covalently bonded or anionic sulfur. chebi_ontology sulphides CHEBI:26822 sulfide CHEBI:26822 sulphides ChEBI Any sulfurous acid derivative that is a salt or an ester of sulfurous acid. Wikipedia:Sulfite chebi_ontology Sulfite sulfito sulfitos sulphites CHEBI:26823 sulfites CHEBI:26823 Sulfite ChEBI sulfito ChEBI sulfitos ChEBI sulphites ChEBI KEGG:C00087 KEGG:D06527 PPDB:605 WebElements:S chebi_ontology 16S Elemental sulfur S Schwefel azufre soufre sulfur sulphur theion CHEBI:26833 sulfur atom CHEBI:26833 16S IUPAC Elemental sulfur KEGG_COMPOUND S IUPAC S KEGG_COMPOUND Schwefel ChEBI azufre ChEBI soufre ChEBI sulfur ChEBI sulfur UniProt sulphur ChEBI theion IUPAC chebi_ontology sulfur-containing amino acids CHEBI:26834 sulfur-containing amino acid CHEBI:26834 sulfur-containing amino acids ChEBI sulfur molecular entity chebi_ontology sulfur molecular entities CHEBI:26835 sulfur molecular entity CHEBI:26835 sulfur molecular entity ChEBI sulfur molecular entities ChEBI A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom. KEGG:C00059 KEGG:D05963 KNApSAcK:C00007530 MolBase:4 PPDB:606 Wikipedia:Sulfuric_acid Sulfuric acid sulfuric acid chebi_ontology Acide sulfurique Acido sulfurico Acidum sulfuricum H2SO4 Schwefelsaeureloesungen [S(OH)2O2] [SO2(OH)2] sulphuric acid CHEBI:26836 sulfuric acid CHEBI:26836 Sulfuric acid KEGG_COMPOUND sulfuric acid ChEBI Acide sulfurique ChemIDplus Acido sulfurico ChemIDplus Acidum sulfuricum ChemIDplus H2SO4 IUPAC Schwefelsaeureloesungen ChemIDplus [S(OH)2O2] MolBase [SO2(OH)2] IUPAC sulphuric acid MolBase Any oxacycle having an oxolane (tetrahydrofuran) skeleton. chebi_ontology CHEBI:26912 oxolanes CHEBI:26912 An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms. chebi_ontology heterotricyclic compounds organic heterotricyclic compounds CHEBI:26979 organic heterotricyclic compound CHEBI:26979 heterotricyclic compounds ChEBI organic heterotricyclic compounds ChEBI Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group. chebi_ontology CHEBI:27024 toluenes CHEBI:27024 Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Wikipedia:Micronutrient chebi_ontology micronutrients trace elements CHEBI:27027 micronutrient CHEBI:27027 micronutrients ChEBI trace elements ChEBI An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell. chebi_ontology Uebergangselement Uebergangsmetalle metal de transicion metal de transition metales de transicion metaux de transition transition element transition elements transition metal transition metals CHEBI:27081 transition element atom CHEBI:27081 Uebergangselement ChEBI Uebergangsmetalle ChEBI metal de transicion ChEBI metal de transition ChEBI metales de transicion ChEBI metaux de transition ChEBI transition element ChEBI transition elements ChEBI transition metal ChEBI transition metals ChEBI A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups. KEGG:C19542 KEGG:D07254 Wikipedia:Triaziquone chebi_ontology 1,1',1''-(3,6-Dioxo-1,4-cyclohexadiene-1,2,4-triyl)trisaziridine 2,3,5-Ethylenimine-1,4-benzoquinone 2,3,5-Tri(1-aziridinyl)-p-benzoquinone 2,3,5-Tri-(1-aziridinyl)-p-benzoquinone 2,3,5-Triethyleneimino-1,4-benzoquinone 2,3,5-Tris(1-aziridino)-p-benzoquinone 2,3,5-Tris(1-aziridinyl)-2,5-cyclohexadiene-1,4-dione 2,3,5-Tris(1-aziridinyl)-p-benzoquinone 2,3,5-Tris(aziridino)-1,4-benzoquinone 2,3,5-Tris(ethyleneimino)-1,4-benzoquinone 2,3,5-Tris(ethylenimino)-1,4-benzoquinone 2,3,5-Tris(ethylenimino)-p-benzoquinone 2,3,5-Tris(ethylenimino)benzoquinone 2,3,5-Trisethyleneiminobenzoquinone Triazichon Triethyleneaminobenzoquinone Tris(1-aziridinyl)-p-benzoquinone Tris(aziridinyl)-p-benzoquinone Tris(aziridinyl)-para-benzoquinone Tris(ethyleneimino)benzoquinone CHEBI:27090 triaziquone CHEBI:27090 1,1',1''-(3,6-Dioxo-1,4-cyclohexadiene-1,2,4-triyl)trisaziridine ChemIDplus 2,3,5-Ethylenimine-1,4-benzoquinone NIST_Chemistry_WebBook 2,3,5-Tri(1-aziridinyl)-p-benzoquinone NIST_Chemistry_WebBook 2,3,5-Tri-(1-aziridinyl)-p-benzoquinone ChemIDplus 2,3,5-Triethyleneimino-1,4-benzoquinone ChemIDplus 2,3,5-Tris(1-aziridino)-p-benzoquinone ChemIDplus 2,3,5-Tris(1-aziridinyl)-2,5-cyclohexadiene-1,4-dione NIST_Chemistry_WebBook 2,3,5-Tris(1-aziridinyl)-p-benzoquinone ChemIDplus 2,3,5-Tris(aziridino)-1,4-benzoquinone ChemIDplus 2,3,5-Tris(ethyleneimino)-1,4-benzoquinone ChemIDplus 2,3,5-Tris(ethylenimino)-1,4-benzoquinone ChemIDplus 2,3,5-Tris(ethylenimino)-p-benzoquinone ChemIDplus 2,3,5-Tris(ethylenimino)benzoquinone ChemIDplus 2,3,5-Trisethyleneiminobenzoquinone ChemIDplus Triazichon ChemIDplus Triethyleneaminobenzoquinone ChemIDplus Tris(1-aziridinyl)-p-benzoquinone ChemIDplus Tris(aziridinyl)-p-benzoquinone NIST_Chemistry_WebBook Tris(aziridinyl)-para-benzoquinone KEGG_COMPOUND Tris(ethyleneimino)benzoquinone ChemIDplus chebi_ontology trimethylxanthines CHEBI:27134 trimethylxanthine CHEBI:27134 trimethylxanthines ChEBI chebi_ontology heterobicyclic compounds organic heterobicyclic compounds CHEBI:27171 organic heterobicyclic compound CHEBI:27171 heterobicyclic compounds ChEBI organic heterobicyclic compounds ChEBI A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid. chebi_ontology univalent acyl group univalent carboacyl groups univalent carboxylic acyl groups CHEBI:27207 univalent carboacyl group CHEBI:27207 univalent acyl group ChEBI univalent carboacyl groups ChEBI univalent carboxylic acyl groups ChEBI chebi_ontology CHEBI:27242 uridines CHEBI:27242 chebi_ontology carbamic acid, vinyl ester ethenyl carbamate CHEBI:27292 vinyl carbamate CHEBI:27292 carbamic acid, vinyl ester ChemIDplus ethenyl carbamate ChemIDplus Any plant metabolite that is found naturally as a component of a volatile oil. Wikipedia:Essential_oil chebi_ontology essential oil component essential oil components ethereal oil component ethereal oil components volatile oil components CHEBI:27311 volatile oil component CHEBI:27311 essential oil component ChEBI essential oil components ChEBI ethereal oil component ChEBI ethereal oil components ChEBI volatile oil components ChEBI Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine. chebi_ontology wasserloesliche Vitamine water-soluble vitamin water-soluble vitamins CHEBI:27314 water-soluble vitamin (role) CHEBI:27314 wasserloesliche Vitamine ChEBI water-soluble vitamin ChEBI water-soluble vitamins ChEBI A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer). chebi_ontology compose zwitterionique compuestos zwitterionicos zwitteriones zwitterionic compounds CHEBI:27369 zwitterion CHEBI:27369 compose zwitterionique IUPAC compuestos zwitterionicos IUPAC zwitteriones IUPAC zwitterionic compounds IUPAC An alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl. CHEBI:6813 KEGG:C11145 MetaCyc:CPD-3746 Wikipedia:Methanesulfonic_acid Methanesulfonic acid chebi_ontology Methansulfonsaeure methylsulfonic acid CHEBI:27376 methanesulfonic acid CHEBI:27376 Methanesulfonic acid KEGG_COMPOUND Methansulfonsaeure ChEBI methylsulfonic acid NIST_Chemistry_WebBook An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. CHEBI:24075 CHEBI:42610 CHEBI:5140 CHEBI:569217 Chemspider:5815 DrugBank:DB00158 FooDB:FDB014504 HMDB:HMDB0000121 KEGG:C00504 KEGG:D00070 KNApSAcK:C00001539 LINCS:LSM-5355 MetaCyc:CPD-12826 PDBeChem:FOL Wikipedia:Folic_Acid chebi_ontology (2S)-2-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzamido)pentanedioic acid Folate Folsaeure N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid N-pteroyl-L-glutamic acid PGA PteGlu pteroyl-L-glutamic acid pteroyl-L-monoglutamic acid pteroylglutamic acid pteroylmonoglutamic acid vitamin B11 vitamin B9 vitamin Bc vitamin Be vitamin M CHEBI:27470 folic acid CHEBI:27470 (2S)-2-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzamido)pentanedioic acid IUPAC Folate KEGG_COMPOUND Folsaeure ChEBI N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid PDBeChem N-pteroyl-L-glutamic acid ChEBI PGA NIST_Chemistry_WebBook PteGlu NIST_Chemistry_WebBook pteroyl-L-glutamic acid ChemIDplus pteroyl-L-monoglutamic acid ChemIDplus pteroylglutamic acid KEGG_COMPOUND pteroylmonoglutamic acid ChemIDplus vitamin B11 ChemIDplus vitamin B9 ChemIDplus vitamin Bc ChemIDplus vitamin Be ChemIDplus vitamin M ChemIDplus CHEBI:25356 CHEBI:6953 DrugBank:DB00305 KEGG:C06681 KEGG:D00208 KNApSAcK:C00018668 LINCS:LSM-6310 Wikipedia:Mitomycin Mitomycin C chebi_ontology 7-Amino-9alpha-methoxymitosane Ametycine MMC Mitocin-C Mitomycin Mutamycin CHEBI:27504 mitomycin C CHEBI:27504 Mitomycin C KEGG_COMPOUND 7-Amino-9alpha-methoxymitosane ChemIDplus Ametycine ChemIDplus MMC ChemIDplus Mitocin-C ChemIDplus Mitomycin KEGG_COMPOUND Mutamycin ChemIDplus CHEBI:22915 CHEBI:3152 KEGG:C06266 WebElements:B chebi_ontology 5B B Bor Boron boracium bore boro boron CHEBI:27560 boron atom CHEBI:27560 5B IUPAC B KEGG_COMPOUND Bor ChEBI Boron KEGG_COMPOUND boracium ChEBI bore ChEBI boro ChEBI boron ChEBI A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom. CHEBI:24001 CHEBI:4900 HMDB:HMDB0031305 KEGG:C06548 KEGG:D03474 Wikipedia:Oxirane chebi_ontology 1,2-Epoxyaethan 1,2-epoxyethane Aethylenoxid Amprolene Anprolene Anproline Dihydrooxirene Dimethylene oxide ETO Ethylene oxide Oxacyclopropane Oxane Oxidoethane Oxyfume epoxyethane ethene oxide oxyde d'ethylene CHEBI:27561 oxirane CHEBI:27561 1,2-Epoxyaethan ChemIDplus 1,2-epoxyethane NIST_Chemistry_WebBook Aethylenoxid ChemIDplus Amprolene ChemIDplus Anprolene NIST_Chemistry_WebBook Anproline ChemIDplus Dihydrooxirene ChemIDplus Dimethylene oxide ChemIDplus ETO ChemIDplus Ethylene oxide KEGG_COMPOUND Oxacyclopropane ChemIDplus Oxane ChemIDplus Oxidoethane ChemIDplus Oxyfume ChEBI epoxyethane NIST_Chemistry_WebBook ethene oxide NIST_Chemistry_WebBook oxyde d'ethylene ChemIDplus CHEBI:23009 CHEBI:3399 KEGG:C06265 WebElements:C chebi_ontology 6C C Carbon Kohlenstoff carbon carbone carbonium carbono CHEBI:27594 carbon atom CHEBI:27594 6C IUPAC C IUPAC C KEGG_COMPOUND Carbon KEGG_COMPOUND Kohlenstoff ChEBI carbon ChEBI carbone ChEBI carbonium ChEBI carbono ChEBI CHEBI:22218 CHEBI:2446 DrugBank:DB00970 KEGG:C06770 KEGG:D00214 LINCS:LSM-5783 Wikipedia:Dactinomycin Actinomycin D chebi_ontology 2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide ActD Dactinomycin actinomycin C1 actinomycin IV CHEBI:27666 actinomycin D CHEBI:27666 Actinomycin D KEGG_COMPOUND 2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide ChemIDplus ActD ChEBI Dactinomycin KEGG_COMPOUND actinomycin C1 ChEBI actinomycin IV ChemIDplus A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee. CHEBI:22982 CHEBI:3295 CHEBI:41472 DrugBank:DB00201 HMDB:HMDB0001847 KEGG:C07481 KEGG:D00528 KNApSAcK:C00001492 LINCS:LSM-2026 MetaCyc:1-3-7-TRIMETHYLXANTHINE PDBeChem:CFF Wikipedia:Caffeine CAFFEINE Caffeine caffeine chebi_ontology 1,3,7-Trimethylxanthine 1,3,7-trimethyl-2,6-dioxopurine 1,3,7-trimethylpurine-2,6-dione 1,3,7-trimethylxanthine 1-methyltheobromine 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion 7-methyltheophylline Coffein Koffein Thein anhydrous caffeine cafeina cafeine guaranine mateina methyltheobromine teina theine CHEBI:27732 caffeine CHEBI:27732 CAFFEINE PDBeChem Caffeine KEGG_COMPOUND caffeine UniProt 1,3,7-Trimethylxanthine KEGG_COMPOUND 1,3,7-trimethyl-2,6-dioxopurine ChemIDplus 1,3,7-trimethylpurine-2,6-dione IUPHAR 1,3,7-trimethylxanthine NIST_Chemistry_WebBook 1-methyltheobromine ChemIDplus 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion NIST_Chemistry_WebBook 7-methyltheophylline NIST_Chemistry_WebBook Coffein ChemIDplus Koffein ChemIDplus Thein ChemIDplus anhydrous caffeine KEGG_DRUG cafeina ChemIDplus cafeine ChEBI guaranine IUPHAR mateina ChemIDplus methyltheobromine IUPHAR teina ChEBI theine NIST_Chemistry_WebBook A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2. CHEBI:18881 CHEBI:49557 CHEBI:497 DrugBank:DB03733 HMDB:HMDB0029571 KEGG:C06752 MetaCyc:12-DICHLOROETHANE PDBeChem:DCE PPDB:2774 Wikipedia:1,2-Dichloroethane 1,2-DICHLOROETHANE 1,2-Dichloroethane 1,2-dichloroethane chebi_ontology 1,2-DCE 1,2-Dichloraethan Aethylenchlorid Aethylendichlorid DCE Dutch liquid EDC Ethylene dichloride Glycol dichloride alpha,beta-dichloroethane ethane dichloride ethylene chloride CHEBI:27789 1,2-dichloroethane CHEBI:27789 1,2-DICHLOROETHANE PDBeChem 1,2-Dichloroethane KEGG_COMPOUND 1,2-dichloroethane UniProt 1,2-DCE NIST_Chemistry_WebBook 1,2-Dichloraethan ChEBI Aethylenchlorid ChEBI Aethylendichlorid ChEBI DCE ChemIDplus Dutch liquid KEGG_COMPOUND EDC ChemIDplus Ethylene dichloride KEGG_COMPOUND Glycol dichloride KEGG_COMPOUND alpha,beta-dichloroethane NIST_Chemistry_WebBook ethane dichloride ChemIDplus ethylene chloride ChemIDplus A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups). CHEBI:23314 CHEBI:3722 DrugBank:DB00515 HMDB:HMDB0014656 KEGG:C06911 KEGG:D00275 MetaCyc:CPD0-1392 MolBase:25 Patent:DE2318020 Patent:DE2329485 Wikipedia:Cisplatin Cisplatin chebi_ontology CDDP Peyrone's chloride Peyrone's salt Platamine [PtCl2(NH3)2] cis-DDP cis-Diamminedichloroplatinum(II) cis-[PtCl2(NH3)2] cis-diamminedichloroplatinum cis-diammineplatinum(II) dichloride cis-dichlorodiammineplatinum(II) cis-platin CHEBI:27899 cisplatin CHEBI:27899 Cisplatin KEGG_COMPOUND CDDP KEGG_COMPOUND Peyrone's chloride ChemIDplus Peyrone's salt ChEBI Platamine DrugBank [PtCl2(NH3)2] KEGG_COMPOUND cis-DDP ChemIDplus cis-Diamminedichloroplatinum(II) KEGG_COMPOUND cis-[PtCl2(NH3)2] MolBase cis-diamminedichloroplatinum ChemIDplus cis-diammineplatinum(II) dichloride ChemIDplus cis-dichlorodiammineplatinum(II) ChemIDplus cis-platin ChEBI CHEBI:27109 CHEBI:9708 KEGG:C07642 tretamine chebi_ontology 2,4,6-tri(1-aziridinyl)-1,3,5-triazine 2,4,6-tris(1-aziridinyl)-1,3,5-triazine 2,4,6-tris(1-aziridinyl)-s-triazine 2,4,6-tris(aziridin-1-yl)-1,3,5-triazine TEM Triethylenemelamine Trisaziridinyltriazine CHEBI:27919 tretamine CHEBI:27919 tretamine ChemIDplus 2,4,6-tri(1-aziridinyl)-1,3,5-triazine NIST_Chemistry_WebBook 2,4,6-tris(1-aziridinyl)-1,3,5-triazine NIST_Chemistry_WebBook 2,4,6-tris(1-aziridinyl)-s-triazine NIST_Chemistry_WebBook 2,4,6-tris(aziridin-1-yl)-1,3,5-triazine ChEBI TEM ChEBI Triethylenemelamine KEGG_COMPOUND Trisaziridinyltriazine KEGG_COMPOUND An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group. CHEBI:25984 CHEBI:8089 KEGG:C02057 Wikipedia:Phenylalanine Phenylalanine phenylalanine chebi_ontology DL-Phenylalanine F PHE Phenylalanin alpha-Amino-beta-phenylpropionic acid fenilalanina CHEBI:28044 phenylalanine CHEBI:28044 Phenylalanine KEGG_COMPOUND phenylalanine ChEBI DL-Phenylalanine KEGG_COMPOUND F ChEBI PHE ChEBI Phenylalanin ChEBI alpha-Amino-beta-phenylpropionic acid KEGG_COMPOUND fenilalanina ChEBI A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. CHEBI:24529 CHEBI:5681 DrugBank:DB01094 HMDB:HMDB0005782 KEGG:C01709 KNApSAcK:C00000968 LINCS:LSM-20933 MetaCyc:CPD-7072 Wikipedia:Hesperetin Hesperetin chebi_ontology (-)-(S)-hesperetin (-)-hesperetin (2S)-hesperetin (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one 3',5,7-Trihydroxy-4'-methoxyflavanone CHEBI:28230 hesperetin CHEBI:28230 Hesperetin KEGG_COMPOUND (-)-(S)-hesperetin ChEBI (-)-hesperetin ChEBI (2S)-hesperetin UniProt (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one ChEBI 3',5,7-Trihydroxy-4'-methoxyflavanone KEGG_COMPOUND A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents. CHEBI:23801 CHEBI:42138 CHEBI:4612 Chemspider:659 DrugBank:DB01093 FooDB:FDB000764 HMDB:HMDB0002151 KEGG:C11143 KEGG:D01043 KNApSAcK:C00053120 LINCS:LSM-36361 MetaCyc:DMSO PDBeChem:DMS Wikipedia:Dimethyl_sulfoxide DIMETHYL SULFOXIDE Dimethyl sulfoxide dimethyl sulfoxide chebi_ontology (CH3)2SO DMSO Dimethylsulfoxid S(O)Me2 dimethyl sulfur oxide dimethyl sulphoxide dmso methylsulfinylmethane sulfinylbis(methane) CHEBI:28262 dimethyl sulfoxide CHEBI:28262 DIMETHYL SULFOXIDE PDBeChem Dimethyl sulfoxide KEGG_COMPOUND dimethyl sulfoxide UniProt (CH3)2SO NIST_Chemistry_WebBook DMSO KEGG_COMPOUND Dimethylsulfoxid ChEBI S(O)Me2 ChEBI dimethyl sulfur oxide NIST_Chemistry_WebBook dimethyl sulphoxide ChemIDplus dmso IUPAC methylsulfinylmethane ChemIDplus sulfinylbis(methane) ChemIDplus A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae. CHEBI:18880 CHEBI:496 HMDB:HMDB0060334 KEGG:C11088 MetaCyc:12-DIBROMOETHANE PPDB:1484 Wikipedia:1,2-Dibromoethane 1,2-Dibromoethane 1,2-dibromoethane chebi_ontology DBE EDB Ethylene dibromide alpha,beta-dibromoethane alpha,omega-dibromoethane ethylene bromide sym-Dibromoethane CHEBI:28534 1,2-dibromoethane CHEBI:28534 1,2-Dibromoethane KEGG_COMPOUND 1,2-dibromoethane UniProt DBE NIST_Chemistry_WebBook EDB NIST_Chemistry_WebBook Ethylene dibromide KEGG_COMPOUND alpha,beta-dibromoethane NIST_Chemistry_WebBook alpha,omega-dibromoethane ChemIDplus ethylene bromide NIST_Chemistry_WebBook sym-Dibromoethane ChemIDplus A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised. CHEBI:22504 CHEBI:23002 CHEBI:3386 CHEBI:44573 DrugBank:DB04261 KEGG:C01563 PDBeChem:OUT Wikipedia:Carbamic_acid CARBAMIC ACID Carbamic acid chebi_ontology Aminoameisensaeure Aminoformic acid Carbamate Carbamidsaeure CHEBI:28616 carbamic acid CHEBI:28616 CARBAMIC ACID PDBeChem Carbamic acid KEGG_COMPOUND Aminoameisensaeure ChEBI Aminoformic acid KEGG_COMPOUND Carbamate KEGG_COMPOUND Carbamidsaeure ChEBI CHEBI:26080 CHEBI:8168 KEGG:C06262 WebElements:P chebi_ontology 15P P Phosphor Phosphorus fosforo phosphore phosphorus CHEBI:28659 phosphorus atom CHEBI:28659 15P IUPAC P IUPAC P KEGG_COMPOUND Phosphor ChEBI Phosphorus KEGG_COMPOUND fosforo ChEBI phosphore ChEBI phosphorus ChEBI CHEBI:23376 CHEBI:3874 KEGG:C00070 WebElements:Cu chebi_ontology 29Cu Copper Cu Kupfer cobre copper cuivre cuprum CHEBI:28694 copper atom CHEBI:28694 29Cu IUPAC Copper KEGG_COMPOUND Cu ChEBI Cu IUPAC Kupfer ChEBI cobre ChEBI copper ChEBI cuivre ChEBI cuprum IUPAC A metal fluoride salt with a Na(+) counterion. CHEBI:26713 CHEBI:9178 KEGG:C08142 KEGG:D00943 Wikipedia:Sodium_Fluoride Sodium fluoride chebi_ontology NaF CHEBI:28741 sodium fluoride CHEBI:28741 Sodium fluoride KEGG_COMPOUND NaF IUPAC A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. CHEBI:24530 CHEBI:5682 DrugBank:DB04703 HMDB:HMDB0003265 KEGG:C09755 KEGG:D01038 KNApSAcK:C00000970 LINCS:LSM-2858 MetaCyc:CPD-7075 Wikipedia:Hesperidin Hesperidin chebi_ontology (2S)-hesperidin (S)-(-)-hesperidin Cirantin Ciratin Hesperetin 7-O-rutinoside Hesperidoside CHEBI:28775 hesperidin CHEBI:28775 Hesperidin KEGG_COMPOUND (2S)-hesperidin UniProt (S)-(-)-hesperidin ChemIDplus Cirantin ChemIDplus Ciratin KEGG_COMPOUND Hesperetin 7-O-rutinoside KEGG_COMPOUND Hesperidoside ChemIDplus A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia. CHEBI:25817 CHEBI:3601 CHEBI:48770 DrugBank:DB00291 KEGG:D00266 LINCS:LSM-2645 PDBeChem:CBL Wikipedia:Chlorambucil CHLORAMBUCIL Chlorambucil chebi_ontology 4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid Ambochlorin Leukeran N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid chloraminophen gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid phenylbutyric acid nitrogen mustard CHEBI:28830 chlorambucil CHEBI:28830 CHLORAMBUCIL PDBeChem Chlorambucil KEGG_DRUG 4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid NIST_Chemistry_WebBook 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid NIST_Chemistry_WebBook Ambochlorin NIST_Chemistry_WebBook Leukeran NIST_Chemistry_WebBook N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid NIST_Chemistry_WebBook chloraminophen ChemIDplus gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid NIST_Chemistry_WebBook phenylbutyric acid nitrogen mustard ChemIDplus Members of the class of flavans with a 3,4-dihydro-2-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives. CHEBI:13636 CHEBI:24038 CHEBI:24054 MetaCyc:FLAVANONES Wikipedia:Flavanone chebi_ontology 2,3-dihydroflavones a flavanone CHEBI:28863 flavanones CHEBI:28863 2,3-dihydroflavones ChEBI a flavanone UniProt The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid. CHEBI:13634 CHEBI:24022 CHEBI:4985 KEGG:C02403 Fatty acid anion chebi_ontology Alkanate Fettsaeureanion Fettsaeureanionen a fatty acid acido graso anionico acidos grasos anionicos anion de l'acide gras fatty acid anions CHEBI:28868 fatty acid anion CHEBI:28868 Fatty acid anion KEGG_COMPOUND Alkanate KEGG_COMPOUND Fettsaeureanion ChEBI Fettsaeureanionen ChEBI a fatty acid UniProt acido graso anionico ChEBI acidos grasos anionicos ChEBI anion de l'acide gras ChEBI fatty acid anions ChEBI A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring. CHEBI:25815 CHEBI:6742 DrugBank:DB01042 KEGG:D00369 Patent:US108552 Patent:US275057 Patent:US3032584 Patent:US3032585 Wikipedia:Melphalan chebi_ontology 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine 4-(Bis(2-chloroethyl)amino)-L-phenylalanine L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine L-PAM L-Phenylalanine mustard L-Sarcolysine Phenylalanine mustard Phenylalanine nitrogen mustard p-Bis(beta-chloroethyl)aminophenylalanine p-Di-(2-chloroethyl)amino-L-phenylalanine p-L-Sarcolysin p-N,N-bis(2-chloroethyl)amino-L-phenylalanine p-N-Bis(2-chloroethyl)amino-L-phenylalanine CHEBI:28876 melphalan CHEBI:28876 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine ChemIDplus 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine ChemIDplus 4-(Bis(2-chloroethyl)amino)-L-phenylalanine ChemIDplus L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine ChemIDplus L-PAM ChemIDplus L-Phenylalanine mustard ChemIDplus L-Sarcolysine ChemIDplus Phenylalanine mustard ChemIDplus Phenylalanine nitrogen mustard ChemIDplus p-Bis(beta-chloroethyl)aminophenylalanine ChemIDplus p-Di-(2-chloroethyl)amino-L-phenylalanine ChemIDplus p-L-Sarcolysin ChemIDplus p-N,N-bis(2-chloroethyl)amino-L-phenylalanine ChEBI p-N-Bis(2-chloroethyl)amino-L-phenylalanine ChemIDplus A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant. CHEBI:18936 CHEBI:3225 DrugBank:DB01008 KEGG:C06862 KEGG:D00248 LINCS:LSM-5388 Patent:US2917432 Wikipedia:Busulfan Busulfan chebi_ontology 1,4-Bis(methanesulfonoxy)butane 1,4-Butanediol dimethanesulfonate 1,4-Dimesyloxybutane 1,4-Dimethanesulfonoxybutane Tetramethylene bis(methanesulfonate) CHEBI:28901 busulfan CHEBI:28901 Busulfan KEGG_DRUG 1,4-Bis(methanesulfonoxy)butane ChemIDplus 1,4-Butanediol dimethanesulfonate ChemIDplus 1,4-Dimesyloxybutane ChemIDplus 1,4-Dimethanesulfonoxybutane ChemIDplus Tetramethylene bis(methanesulfonate) ChemIDplus An onium cation obtained by protonation of ammonia. CHEBI:22534 CHEBI:49783 CHEBI:7435 KEGG:C01342 MetaCyc:AMMONIUM MolBase:929 PDBeChem:NH4 Wikipedia:Ammonium ammonium chebi_ontology Ammonium(1+) NH4(+) NH4+ [NH4](+) ammonium cation ammonium ion CHEBI:28938 ammonium CHEBI:28938 ammonium ChEBI Ammonium(1+) ChemIDplus NH4(+) IUPAC NH4(+) UniProt NH4+ KEGG_COMPOUND [NH4](+) MolBase ammonium cation ChemIDplus ammonium ion PDBeChem CHEBI:24011 CHEBI:4968 KEGG:C09438 KNApSAcK:C00001857 Fagaronine chebi_ontology CHEBI:28954 fagaronine CHEBI:28954 Fagaronine KEGG_COMPOUND A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid. CHEBI:13632 CHEBI:23688 CHEBI:23689 CHEBI:38711 dicarboxylic acid dianion chebi_ontology a dicarboxylate dicarboxylate dicarboxylates dicarboxylic acid dianions CHEBI:28965 dicarboxylic acid dianion CHEBI:28965 dicarboxylic acid dianion ChEBI a dicarboxylate UniProt dicarboxylate ChEBI dicarboxylates ChEBI dicarboxylic acid dianions ChEBI CHEBI:13351 CHEBI:23017 CHEBI:23744 CHEBI:3401 KEGG:C01353 PDBeChem:CO3 Carbonic acid chebi_ontology Dihydrogen carbonate H2CO3 Koehlensaeure [CO(OH)2] CHEBI:28976 carbonic acid CHEBI:28976 Carbonic acid KEGG_COMPOUND Dihydrogen carbonate KEGG_COMPOUND H2CO3 IUPAC H2CO3 KEGG_COMPOUND Koehlensaeure ChEBI [CO(OH)2] IUPAC An ion of copper carrying a double positive charge. CHEBI:20882 CHEBI:23380 CHEBI:49550 PDBeChem:CU chebi_ontology COPPER (II) ION Cu(2+) Cu(II) Cu2+ copper(II) cation copper, ion (Cu2+) cupric ion CHEBI:29036 copper(2+) CHEBI:29036 COPPER (II) ION PDBeChem Cu(2+) UniProt Cu(II) ChEBI Cu2+ ChEBI copper(II) cation ChEBI copper, ion (Cu2+) ChemIDplus cupric ion ChEBI The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated. CHEBI:13626 CHEBI:13945 CHEBI:23026 CHEBI:58657 chebi_ontology a carboxylate carboxylic acid anions carboxylic anions CHEBI:29067 carboxylic acid anion CHEBI:29067 a carboxylate UniProt carboxylic acid anions ChEBI carboxylic anions ChEBI A monoatomic monocation obtained from sodium. CHEBI:26717 CHEBI:49766 CHEBI:9175 KEGG:C01330 PDBeChem:NA chebi_ontology Na(+) Na+ SODIUM ION CHEBI:29101 sodium(1+) CHEBI:29101 Na(+) IUPAC Na(+) UniProt Na+ KEGG_COMPOUND SODIUM ION PDBeChem chebi_ontology HSHO3 Sulfonsaeure [SHO2(OH)] acide sulfonique sulphonic acid CHEBI:29214 sulfonic acid CHEBI:29214 HSHO3 IUPAC Sulfonsaeure ChEBI [SHO2(OH)] IUPAC acide sulfonique ChEBI sulphonic acid ChEBI A diatomic molecule containing covalently bonded hydrogen and fluorine atoms. KEGG:C16487 Hydrogen fluoride chebi_ontology Fluoride Fluorwasserstoff HF Hydrogenfluorid [HF] fluorure d'hydrogene hydrofluoric acid CHEBI:29228 hydrogen fluoride CHEBI:29228 Hydrogen fluoride KEGG_COMPOUND Fluoride KEGG_COMPOUND Fluorwasserstoff ChEBI HF IUPAC Hydrogenfluorid ChEBI [HF] IUPAC fluorure d'hydrogene ChEBI hydrofluoric acid ChemIDplus Nucleus of the (3)H atom. chebi_ontology (3)1H(+) (3)H(+) T(+) t t(+) CHEBI:29234 triton CHEBI:29234 (3)1H(+) IUPAC (3)H(+) IUPAC T(+) IUPAC t IUPAC t(+) IUPAC The radioactive isotope of hydrogen with relative atomic mass 3.016049 and half-life of 12.33 years (from Greek taurhoiotatauomicronsigma, third). chebi_ontology (3)1H (3)H T hydrogen-3 tritio tritium ueberschwerer Wasserstoff CHEBI:29238 tritium atom CHEBI:29238 (3)1H IUPAC (3)H IUPAC T IUPAC hydrogen-3 ChEBI tritio ChEBI tritium ChEBI ueberschwerer Wasserstoff ChEBI chebi_ontology H2BO3(-) [BO(OH)2](-) CHEBI:29254 dihydrogenborate CHEBI:29254 H2BO3(-) IUPAC [BO(OH)2](-) IUPAC chebi_ontology HBO3(2-) [BO2(OH)](2-) CHEBI:29255 hydrogenborate CHEBI:29255 HBO3(2-) IUPAC [BO2(OH)](2-) IUPAC CHEBI:13810 CHEBI:22325 CHEBI:2583 chebi_ontology alkyl sulfates CHEBI:29281 alkyl sulfate CHEBI:29281 alkyl sulfates ChEBI chebi_ontology NH2(-) CHEBI:29337 azanide CHEBI:29337 NH2(-) IUPAC A divalent inorganic anion resulting from the removal of two protons from ammonia. chebi_ontology NH(2-) imide CHEBI:29340 hydridonitrate(2-) CHEBI:29340 NH(2-) IUPAC imide IUPAC A carboxamide derived from a monocarboxylic acid. CHEBI:13211 CHEBI:22207 CHEBI:25383 CHEBI:6977 chebi_ontology monocarboxylic acid amides CHEBI:29347 monocarboxylic acid amide CHEBI:29347 monocarboxylic acid amides ChEBI chebi_ontology -NO2 CHEBI:29785 nitro group CHEBI:29785 -NO2 IUPAC An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. CHEBI:22716 CHEBI:3045 KEGG:C07535 LINCS:LSM-2198 Wikipedia:Benzo(a)pyrene Benzo[a]pyrene chebi_ontology (B(a)P) 3,4-BP 3,4-Benzopyrene 3,4-Benzpyrene BP Benzo(a)pyrene Benzpyrene benzo[def]chrysene CHEBI:29865 benzo[a]pyrene CHEBI:29865 Benzo[a]pyrene KEGG_COMPOUND (B(a)P) ChEBI 3,4-BP NIST_Chemistry_WebBook 3,4-Benzopyrene NIST_Chemistry_WebBook 3,4-Benzpyrene NIST_Chemistry_WebBook BP NIST_Chemistry_WebBook Benzo(a)pyrene ChemIDplus Benzpyrene KEGG_COMPOUND benzo[def]chrysene ChEBI PDBeChem:SFO SULFO GROUP chebi_ontology -S(O)2(OH) CHEBI:29922 sulfo group CHEBI:29922 SULFO GROUP PDBeChem -S(O)2(OH) IUPAC An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group CHEBI:13107 CHEBI:21301 MetaCyc:GLT L-glutamate(1-) chebi_ontology (2S)-2-ammoniopentanedioate L-glutamate L-glutamic acid monoanion L-glutamic acid, ion(1-) CHEBI:29985 L-glutamate(1-) CHEBI:29985 L-glutamate(1-) JCBN (2S)-2-ammoniopentanedioate IUPAC L-glutamate ChEBI L-glutamate UniProt L-glutamic acid monoanion JCBN L-glutamic acid, ion(1-) ChemIDplus An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group CHEBI:12979 CHEBI:21022 MetaCyc:D-GLT D-glutamate(1-) chebi_ontology (2R)-2-ammoniopentanedioate D-glutamate D-glutamic acid monoanion CHEBI:29986 D-glutamate(1-) CHEBI:29986 D-glutamate(1-) JCBN (2R)-2-ammoniopentanedioate IUPAC D-glutamate UniProt D-glutamic acid monoanion JCBN A dicarboxylic acid dianion that is the conjugate base of glutamate(1-). glutamate(2-) chebi_ontology glutamic acid dianion CHEBI:29987 glutamate(2-) CHEBI:29987 glutamate(2-) JCBN glutamic acid dianion JCBN An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid. L-glutamate(2-) chebi_ontology L-glutamic acid dianion CHEBI:29988 L-glutamate(2-) CHEBI:29988 L-glutamate(2-) JCBN L-glutamic acid dianion JCBN D-glutamate(2-) chebi_ontology D-glutamic acid dianion CHEBI:29989 D-glutamate(2-) CHEBI:29989 D-glutamate(2-) JCBN D-glutamic acid dianion JCBN chebi_ontology [C(NH2)3](+) diaminomethaniminium guanidine CHEBI:30087 guanidinium CHEBI:30087 [C(NH2)3](+) ChEBI diaminomethaniminium IUPAC guanidine UniProt CHEBI:23856 CHEBI:4665 KEGG:C00572 chebi_ontology Divalent cation divalent inorganic cations monoatomic dications CHEBI:30412 monoatomic dication CHEBI:30412 Divalent cation KEGG_COMPOUND divalent inorganic cations ChEBI monoatomic dications ChEBI The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects. CHEBI:24082 CHEBI:42460 CHEBI:5145 BPDB:1749 DrugBank:DB01942 HMDB:HMDB0000142 KEGG:C00058 KNApSAcK:C00001182 MetaCyc:FORMATE PDBeChem:FMT Patent:CN101481304 Wikipedia:Formic_acid FORMIC ACID Formic acid chebi_ontology Acide formique Ameisensaeure H-COOH HCO2H HCOOH Methanoic acid aminic acid bilorin formylic acid hydrogen carboxylic acid methoic acid CHEBI:30751 formic acid CHEBI:30751 FORMIC ACID PDBeChem Formic acid KEGG_COMPOUND Acide formique ChemIDplus Ameisensaeure ChemIDplus H-COOH IUPAC HCO2H ChEBI HCOOH NIST_Chemistry_WebBook Methanoic acid KEGG_COMPOUND aminic acid ChemIDplus bilorin ChemIDplus formylic acid ChemIDplus hydrogen carboxylic acid ChemIDplus methoic acid ChEBI A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom. CHEBI:13804 CHEBI:22288 CHEBI:2553 KEGG:C00069 Alcohol chebi_ontology an alcohol CHEBI:30879 alcohol CHEBI:30879 Alcohol KEGG_COMPOUND an alcohol UniProt CHEBI:24004 CHEBI:2954 KEGG:C11687 Aziridine chebi_ontology EI azacyclopropane dimethyleneimine ethyleneimine ethylenimine CHEBI:30969 aziridine CHEBI:30969 Aziridine KEGG_COMPOUND EI NIST_Chemistry_WebBook azacyclopropane NIST_Chemistry_WebBook dimethyleneimine NIST_Chemistry_WebBook ethyleneimine ChemIDplus ethylenimine NIST_Chemistry_WebBook A short-chain fatty acid anion that is the conjugate base of valeric acid; present in ester form as component of many steroid-based pharmaceuticals. CHEBI:14751 CHEBI:25890 chebi_ontology CH3-[CH2]3-COO(-) n-propylacetate pentanoate pentanoic acid, ion(1-) CHEBI:31011 valerate CHEBI:31011 CH3-[CH2]3-COO(-) IUPAC n-propylacetate ChEBI pentanoate UniProt pentanoic acid, ion(1-) ChemIDplus A sulfur-containing amino-acid anion that is the conjugate base of cysteine, obtained by deprotonation of the carboxy group. cysteinate(1-) chebi_ontology 2-amino-3-mercaptopropanoate 2-amino-3-sulfanylpropanoate cys(-) cysteine monoanion CHEBI:32456 cysteinate(1-) CHEBI:32456 cysteinate(1-) JCBN 2-amino-3-mercaptopropanoate ChEBI 2-amino-3-sulfanylpropanoate IUPAC cys(-) IUPAC cysteine monoanion JCBN cysteinate(2-) chebi_ontology 2-amino-3-sulfidopropanoate cysteine dianion CHEBI:32457 cysteinate(2-) CHEBI:32457 cysteinate(2-) JCBN 2-amino-3-sulfidopropanoate IUPAC cysteine dianion JCBN cysteinium chebi_ontology 1-carboxy-2-mercaptoethanaminium H2cys(+) cysteine cation CHEBI:32458 cysteinium CHEBI:32458 cysteinium JCBN 1-carboxy-2-mercaptoethanaminium ChEBI H2cys(+) IUPAC cysteine cation JCBN An optically active form of phenylalaninate having L-configuration. chebi_ontology (2S)-2-amino-3-phenylpropanoate L-phenylalanine anion CHEBI:32486 L-phenylalaninate CHEBI:32486 (2S)-2-amino-3-phenylpropanoate IUPAC L-phenylalanine anion JCBN An optically active form of phenylalaninium having L-configuration. chebi_ontology (1S)-1-carboxy-2-phenylethanaminium L-phenylalanine cation CHEBI:32487 L-phenylalaninium CHEBI:32487 (1S)-1-carboxy-2-phenylethanaminium IUPAC L-phenylalanine cation JCBN The D-enantiomer of phenylalaninate. chebi_ontology (2R)-2-amino-3-phenylpropanoate D-phenylalanine anion CHEBI:32494 D-phenylalaninate CHEBI:32494 (2R)-2-amino-3-phenylpropanoate IUPAC D-phenylalanine anion JCBN An optically active form of phenylalaninium having D-configuration. chebi_ontology (1R)-1-carboxy-2-phenylethanaminium D-phenylalanine cation CHEBI:32495 D-phenylalaninium CHEBI:32495 (1R)-1-carboxy-2-phenylethanaminium IUPAC D-phenylalanine cation JCBN An aromatic amino-acid anion that is the conjugate base of phenylalanine, arising from deprotonation of the carboxy group. chebi_ontology 2-amino-3-phenylpropanoate phenylalanine anion CHEBI:32504 phenylalaninate CHEBI:32504 2-amino-3-phenylpropanoate IUPAC phenylalanine anion JCBN An alpha-amino-acid cation that is the conjugate acid of phenylalanine, arising from protonation of the amino group. chebi_ontology 1-carboxy-2-phenylethanaminium phenylalanine cation CHEBI:32505 phenylalaninium CHEBI:32505 1-carboxy-2-phenylethanaminium IUPAC phenylalanine cation JCBN Any cyclic ether in which the oxygen atom forms part of a 3-membered ring. CHEBI:13828 CHEBI:23930 CHEBI:4812 KEGG:C00722 Wikipedia:Epoxide Epoxide chebi_ontology Alkene oxide Olefin oxide an epoxide epoxides CHEBI:32955 epoxide CHEBI:32955 Epoxide KEGG_COMPOUND Alkene oxide KEGG_COMPOUND Olefin oxide KEGG_COMPOUND an epoxide UniProt epoxides ChEBI An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. CHEBI:22473 CHEBI:2633 KEGG:C00241 Amide chebi_ontology CHEBI:32988 amide CHEBI:32988 Amide KEGG_COMPOUND CHEBI:22911 CHEBI:31299 CHEBI:41248 BPDB:2136 KEGG:C12486 KEGG:D01089 MolBase:1644 PDBeChem:BO3 PPDB:2136 BORIC ACID Boric acid boric acid chebi_ontology B(OH)3 H3BO3 [B(OH)3] boron trihydroxide orthoboric acid CHEBI:33118 boric acid CHEBI:33118 BORIC ACID PDBeChem Boric acid KEGG_COMPOUND boric acid IUPAC B(OH)3 NIST_Chemistry_WebBook H3BO3 IUPAC [B(OH)3] MolBase boron trihydroxide NIST_Chemistry_WebBook orthoboric acid NIST_Chemistry_WebBook boron oxoacid chebi_ontology boron oxoacids oxoacids of boron CHEBI:33145 boron oxoacid CHEBI:33145 boron oxoacid ChEBI boron oxoacids ChEBI oxoacids of boron ChEBI A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term "vitamines" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines. CHEBI:10004 CHEBI:27305 Wikipedia:Vitamin chebi_ontology vitamin vitamina vitaminas vitamine vitamines vitamins vitaminum CHEBI:33229 vitamin (role) CHEBI:33229 vitamin ChEBI vitamina ChEBI vitaminas ChEBI vitamine ChEBI vitamines ChEBI vitamins ChEBI vitaminum ChEBI Intended use of the molecular entity or part thereof by humans. chebi_ontology CHEBI:33232 application CHEBI:33232 A particle not known to have substructure. chebi_ontology elementary particles CHEBI:33233 fundamental particle CHEBI:33233 elementary particles ChEBI A monoatomic entity is a molecular entity consisting of a single atom. chebi_ontology atomic entity monoatomic entities CHEBI:33238 monoatomic entity CHEBI:33238 atomic entity ChEBI monoatomic entities ChEBI An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands). chebi_ontology coordination compounds CHEBI:33240 coordination entity CHEBI:33240 coordination compounds ChEBI chebi_ontology oxoacid derivatives CHEBI:33241 oxoacid derivative CHEBI:33241 oxoacid derivatives ChEBI chebi_ontology inorganic hydrides CHEBI:33242 inorganic hydride CHEBI:33242 inorganic hydrides ChEBI An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system. chebi_ontology organic fundamental parents organic parent hydrides CHEBI:33245 organic fundamental parent CHEBI:33245 organic fundamental parents ChEBI organic parent hydrides ChEBI Any substituent group which does not contain carbon. chebi_ontology inorganic groups CHEBI:33246 inorganic group CHEBI:33246 inorganic groups ChEBI Any substituent group or skeleton containing carbon. chebi_ontology organic groups CHEBI:33247 organic group CHEBI:33247 organic groups ChEBI A univalent group formed by removing a hydrogen atom from a hydrocarbon. hydrocarbyl group chebi_ontology groupe hydrocarbyle grupo hidrocarbilo grupos hidrocarbilo CHEBI:33248 hydrocarbyl group CHEBI:33248 hydrocarbyl group IUPAC groupe hydrocarbyle IUPAC grupo hidrocarbilo IUPAC grupos hidrocarbilo IUPAC Any organic substituent group, regardless of functional type, having one free valence at a carbon atom. chebi_ontology groupe organyle grupo organilo grupos organilo CHEBI:33249 organyl group CHEBI:33249 groupe organyle IUPAC grupo organilo IUPAC grupos organilo IUPAC A chemical entity constituting the smallest component of an element having the chemical properties of the element. CHEBI:22671 CHEBI:23907 chebi_ontology atome atomo atoms atomus element elements CHEBI:33250 atom CHEBI:33250 atome IUPAC atomo IUPAC atoms ChEBI atomus ChEBI element ChEBI elements ChEBI chebi_ontology atomic hydrogen CHEBI:33251 monoatomic hydrogen CHEBI:33251 atomic hydrogen ChEBI A nucleus is the positively charged central portion of an atom, excluding the orbital electrons. chebi_ontology Atomkern Kern noyau noyau atomique nuclei nucleo nucleo atomico nucleus atomi CHEBI:33252 atomic nucleus CHEBI:33252 Atomkern ChEBI Kern ChEBI noyau IUPAC noyau atomique ChEBI nuclei ChEBI nucleo IUPAC nucleo atomico ChEBI nucleus atomi ChEBI Heavy nuclear particle: proton or neutron. nucleon chebi_ontology Nukleon Nukleonen nucleons CHEBI:33253 nucleon CHEBI:33253 nucleon IUPAC Nukleon ChEBI Nukleonen ChEBI nucleons ChEBI A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. primary amide chebi_ontology CHEBI:33256 primary amide CHEBI:33256 primary amide IUPAC A molecular entity all atoms of which have the same atomic number. chebi_ontology homoatomic entity homoatomic molecular entities homoatomic molecular entity CHEBI:33259 elemental molecular entity CHEBI:33259 homoatomic entity ChEBI homoatomic molecular entities ChEBI homoatomic molecular entity ChEBI chebi_ontology CHEBI:33260 elemental hydrogen CHEBI:33260 An organosulfur compound is a compound containing at least one carbon-sulfur bond. CHEBI:23010 CHEBI:25714 Wikipedia:Organosulfur_compounds organosulfur compound chebi_ontology organosulfur compounds CHEBI:33261 organosulfur compound CHEBI:33261 organosulfur compound ChEBI organosulfur compounds ChEBI An anion consisting of more than one atom. chebi_ontology polyatomic anions CHEBI:33273 polyatomic anion CHEBI:33273 polyatomic anions ChEBI chebi_ontology chemical messenger CHEBI:33280 molecular messenger CHEBI:33280 chemical messenger ChEBI A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. CHEBI:22582 chebi_ontology Antibiotika Antibiotikum antibiotic antibiotics antibiotique antimicrobial antimicrobial agents antimicrobials microbicide microbicides CHEBI:33281 antimicrobial agent CHEBI:33281 Antibiotika ChEBI Antibiotikum ChEBI antibiotic ChEBI antibiotics ChEBI antibiotique IUPAC antimicrobial ChEBI antimicrobial agents ChEBI antimicrobials ChEBI microbicide ChEBI microbicides ChEBI A substance (or active part thereof) that kills or slows the growth of bacteria. chebi_ontology antibacterial agents antibacterials bactericide bactericides CHEBI:33282 antibacterial agent CHEBI:33282 antibacterial agents ChEBI antibacterials ChEBI bactericide ChEBI bactericides ChEBI A nutrient is a food component that an organism uses to survive and grow. chebi_ontology nutrients CHEBI:33284 nutrient CHEBI:33284 nutrients ChEBI A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms. chebi_ontology heteroorganic entities organoelement compounds CHEBI:33285 heteroorganic entity CHEBI:33285 heteroorganic entities ChEBI organoelement compounds ChEBI An agrochemical is a substance that is used in agriculture or horticulture. Wikipedia:Agrochemical chebi_ontology agrichemical agrichemicals agricultural chemicals agrochemicals CHEBI:33286 agrochemical CHEBI:33286 agrichemical ChEBI agrichemicals ChEBI agricultural chemicals ChEBI agrochemicals ChEBI A fertilizer is any substance that is added to soil or water to assist the growth of plants. chebi_ontology fertiliser fertilizers CHEBI:33287 fertilizer CHEBI:33287 fertiliser ChEBI fertilizers ChEBI A substance administered to aid diagnosis of a disease. chebi_ontology diagnostic aid CHEBI:33295 diagnostic agent CHEBI:33295 diagnostic aid ChEBI A molecular entity containing one or more atoms of an alkali metal. chebi_ontology alkali metal molecular entities CHEBI:33296 alkali metal molecular entity CHEBI:33296 alkali metal molecular entities ChEBI Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth. chebi_ontology group 15 elements group V elements nitrogenoideos nitrogenoides pnictogene pnictogenes CHEBI:33300 pnictogen CHEBI:33300 group 15 elements ChEBI group V elements ChEBI nitrogenoideos ChEBI nitrogenoides ChEBI pnictogene ChEBI pnictogenes ChEBI A p-block molecular entity containing any pnictogen. pnictogen molecular entity chebi_ontology pnictogen molecular entities CHEBI:33302 pnictogen molecular entity CHEBI:33302 pnictogen molecular entity ChEBI pnictogen molecular entities ChEBI Any p-block element belonging to the group 16 family of the periodic table. chebi_ontology Chalkogen Chalkogene anfigeno anfigenos calcogeno calcogenos chalcogene chalcogenes group 16 elements group VI elements CHEBI:33303 chalcogen CHEBI:33303 Chalkogen ChEBI Chalkogene ChEBI anfigeno ChEBI anfigenos ChEBI calcogeno ChEBI calcogenos ChEBI chalcogene ChEBI chalcogenes ChEBI group 16 elements ChEBI group VI elements ChEBI Any p-block molecular entity containing a chalcogen. chalcogen molecular entity chebi_ontology chalcogen compounds chalcogen molecular entities CHEBI:33304 chalcogen molecular entity CHEBI:33304 chalcogen molecular entity ChEBI chalcogen compounds ChEBI chalcogen molecular entities ChEBI chebi_ontology carbon group element carbon group elements carbonoides cristallogene cristallogenes group IV elements CHEBI:33306 carbon group element atom CHEBI:33306 carbon group element ChEBI carbon group elements ChEBI carbonoides ChEBI cristallogene ChEBI cristallogenes ChEBI group IV elements ChEBI An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl. CHEBI:13204 CHEBI:23028 CHEBI:3408 KEGG:C02391 Wikipedia:Ester Carboxylic ester chebi_ontology a carboxylic ester carboxylic acid esters CHEBI:33308 carboxylic ester CHEBI:33308 Carboxylic ester KEGG_COMPOUND a carboxylic ester UniProt carboxylic acid esters ChEBI chebi_ontology Element der Borgruppe boron group element boron group elements group III elements CHEBI:33317 boron group element atom CHEBI:33317 Element der Borgruppe ChEBI boron group element ChEBI boron group elements ChEBI group III elements ChEBI An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table. chebi_ontology Hauptgruppenelement Hauptgruppenelemente main group element CHEBI:33318 main group element atom CHEBI:33318 Hauptgruppenelement ChEBI Hauptgruppenelemente ChEBI main group element ChEBI A group derived from an arene by removal of a hydrogen atom from a ring carbon atom. chebi_ontology Arylgruppe groupe aryle grupos arilo CHEBI:33338 aryl group CHEBI:33338 Arylgruppe ChEBI groupe aryle IUPAC grupos arilo IUPAC chebi_ontology nickel group element nickel group elements CHEBI:33362 nickel group element atom CHEBI:33362 nickel group element ChEBI nickel group elements ChEBI WebElements:Pt chebi_ontology 78Pt Platin Pt platine platino CHEBI:33364 platinum CHEBI:33364 78Pt IUPAC Platin ChEBI Pt IUPAC platine ChEBI platino ChEBI chebi_ontology PGM Platinmetalle Platinoide platinoid platinum group metal platinum group metals platinum metals CHEBI:33365 platinum group metal atom CHEBI:33365 PGM ChEBI Platinmetalle ChEBI Platinoide ChEBI platinoid ChEBI platinum group metal ChEBI platinum group metals ChEBI platinum metals ChEBI chebi_ontology coinage metals copper group element copper group elements CHEBI:33366 copper group element atom CHEBI:33366 coinage metals ChEBI copper group element ChEBI copper group elements ChEBI chebi_ontology oxoacids of sulfur sulfur oxoacids CHEBI:33402 sulfur oxoacid CHEBI:33402 oxoacids of sulfur ChEBI sulfur oxoacids ChEBI A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). chebi_ontology hydracids CHEBI:33405 hydracid CHEBI:33405 hydracids ChEBI chebi_ontology pnictogen oxoacids CHEBI:33408 pnictogen oxoacid CHEBI:33408 pnictogen oxoacids ChEBI sulfur oxoacid derivative chebi_ontology sulfur oxoacid derivatives CHEBI:33424 sulfur oxoacid derivative CHEBI:33424 sulfur oxoacid derivative ChEBI sulfur oxoacid derivatives ChEBI chebi_ontology monoatomic monoanions CHEBI:33429 monoatomic monoanion CHEBI:33429 monoatomic monoanions ChEBI chebi_ontology CHEBI:33431 elemental chlorine CHEBI:33431 chebi_ontology atomic chlorine CHEBI:33432 monoatomic chlorine CHEBI:33432 atomic chlorine ChEBI chebi_ontology monoatomic halogens CHEBI:33433 monoatomic halogen CHEBI:33433 monoatomic halogens ChEBI elemental halogen chebi_ontology elemental halogens CHEBI:33434 elemental halogen CHEBI:33434 elemental halogen ChEBI elemental halogens ChEBI Arylmethyl groups and derivatives formed by substitution: ArCR2-. benzylic group chebi_ontology benzylic groups groupe benzylique CHEBI:33452 benzylic group CHEBI:33452 benzylic group IUPAC benzylic groups ChEBI groupe benzylique IUPAC A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons. phosphorus oxoacid chebi_ontology Oxosaeure des Phosphors oxoacids of phosphorus phosphorus oxoacids CHEBI:33457 phosphorus oxoacid CHEBI:33457 phosphorus oxoacid ChEBI Oxosaeure des Phosphors ChEBI oxoacids of phosphorus ChEBI phosphorus oxoacids ChEBI pnictogen oxoanion chebi_ontology pnictogen oxoanions CHEBI:33459 pnictogen oxoanion CHEBI:33459 pnictogen oxoanion ChEBI pnictogen oxoanions ChEBI phosphorus oxoanion chebi_ontology oxoanions of phosphorus phosphorus oxoanions CHEBI:33461 phosphorus oxoanion CHEBI:33461 phosphorus oxoanion ChEBI oxoanions of phosphorus ChEBI phosphorus oxoanions ChEBI sulfur oxoanion chebi_ontology oxoanions of sulfur sulfur oxoanions CHEBI:33482 sulfur oxoanion CHEBI:33482 sulfur oxoanion ChEBI oxoanions of sulfur ChEBI sulfur oxoanions ChEBI chalcogen oxoacid chebi_ontology chalcogen oxoacids CHEBI:33484 chalcogen oxoacid CHEBI:33484 chalcogen oxoacid ChEBI chalcogen oxoacids ChEBI chalcogen oxoanion chebi_ontology chalcogen oxoanions CHEBI:33485 chalcogen oxoanion CHEBI:33485 chalcogen oxoanion ChEBI chalcogen oxoanions ChEBI A molecular entity containing one or more atoms of a transition element. chebi_ontology transition element molecular entities transition metal molecular entity CHEBI:33497 transition element molecular entity CHEBI:33497 transition element molecular entities ChEBI transition metal molecular entity ChEBI chebi_ontology alkali metal cations CHEBI:33504 alkali metal cation CHEBI:33504 alkali metal cations ChEBI chebi_ontology transition element cations transition metal cation CHEBI:33515 transition element cation CHEBI:33515 transition element cations ChEBI transition metal cation ChEBI An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity. CHEBI:25217 CHEBI:6788 KEGG:C00050 Wikipedia:Metal chebi_ontology elemental metal elemental metals metal element metal elements metals CHEBI:33521 metal atom CHEBI:33521 elemental metal ChEBI elemental metals ChEBI metal element ChEBI metal elements ChEBI metals ChEBI The sulfur oxoanion formed by deprotonation of sulfonic acid. chebi_ontology SHO3(-) [SHO3](-) sulfonates CHEBI:33543 sulfonate CHEBI:33543 SHO3(-) IUPAC [SHO3](-) IUPAC sulfonates ChEBI An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon. chebi_ontology organosulfonic acids sulfonic acids CHEBI:33551 organosulfonic acid CHEBI:33551 organosulfonic acids ChEBI sulfonic acids ChEBI sulfonic acid derivative chebi_ontology derivatives of sulfonic acid sulfonic acid derivatives CHEBI:33552 sulfonic acid derivative CHEBI:33552 sulfonic acid derivative ChEBI derivatives of sulfonic acid ChEBI sulfonic acid derivatives ChEBI An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid. chebi_ontology organosulfonate organosulfonate oxoanions organosulfonates CHEBI:33554 organosulfonate oxoanion CHEBI:33554 organosulfonate ChEBI organosulfonate oxoanions ChEBI organosulfonates ChEBI Organic derivatives of sulfonic acid in which the sulfo group is linked directly to carbon of an aryl group. chebi_ontology arenesulfonic acids arylsulfonic acid arylsulfonic acids CHEBI:33555 arenesulfonic acid CHEBI:33555 arenesulfonic acids ChEBI arylsulfonic acid ChEBI arylsulfonic acids ChEBI An amino-acid anion obtained by deprotonation of any alpha-amino acid. chebi_ontology alpha-amino acid anion alpha-amino acid anions alpha-amino-acid anions CHEBI:33558 alpha-amino-acid anion CHEBI:33558 alpha-amino acid anion ChEBI alpha-amino acid anions ChEBI alpha-amino-acid anions ChEBI chebi_ontology s-block element s-block elements CHEBI:33559 s-block element atom CHEBI:33559 s-block element ChEBI s-block elements ChEBI Any main group element atom belonging to the p-block of the periodic table. chebi_ontology p-block element p-block elements CHEBI:33560 p-block element atom CHEBI:33560 p-block element ChEBI p-block elements ChEBI chebi_ontology d-block element d-block elements CHEBI:33561 d-block element atom CHEBI:33561 d-block element ChEBI d-block elements ChEBI CHEBI:22705 CHEBI:22711 chebi_ontology CHEBI:33570 benzenediols CHEBI:33570 A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. CHEBI:13428 CHEBI:13627 CHEBI:23027 Wikipedia:Carboxylic_acid chebi_ontology Carbonsaeure Carbonsaeuren Karbonsaeure RC(=O)OH acide carboxylique acides carboxyliques acido carboxilico acidos carboxilicos CHEBI:33575 carboxylic acid CHEBI:33575 Carbonsaeure ChEBI Carbonsaeuren ChEBI Karbonsaeure ChEBI RC(=O)OH IUPAC acide carboxylique IUPAC acides carboxyliques IUPAC acido carboxilico IUPAC acidos carboxilicos IUPAC Any carboxylic acid having a sulfur substituent. chebi_ontology S-containing carboxylic acid S-containing carboxylic acids sulfur-containing carboxylic acids CHEBI:33576 sulfur-containing carboxylic acid CHEBI:33576 S-containing carboxylic acid ChEBI S-containing carboxylic acids ChEBI sulfur-containing carboxylic acids ChEBI A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table. chebi_ontology main group compounds main group molecular entities CHEBI:33579 main group molecular entity CHEBI:33579 main group compounds ChEBI main group molecular entities ChEBI chebi_ontology boron group molecular entities CHEBI:33581 boron group molecular entity CHEBI:33581 boron group molecular entities ChEBI carbon group molecular entity chebi_ontology carbon group molecular entities CHEBI:33582 carbon group molecular entity CHEBI:33582 carbon group molecular entity ChEBI carbon group molecular entities ChEBI Any molecule that consists of a series of atoms joined together to form a ring. Wikipedia:Cyclic_compound chebi_ontology cyclic compounds CHEBI:33595 cyclic compound CHEBI:33595 cyclic compounds ChEBI A cyclic compound having as ring members atoms of the same element only. chebi_ontology isocyclic compounds CHEBI:33597 homocyclic compound CHEBI:33597 isocyclic compounds IUPAC A homocyclic compound in which all of the ring members are carbon atoms. chebi_ontology carbocycle CHEBI:33598 carbocyclic compound CHEBI:33598 carbocycle ChEBI chebi_ontology hydrogen compounds hydrogen molecular entities CHEBI:33608 hydrogen molecular entity CHEBI:33608 hydrogen compounds ChEBI hydrogen molecular entities ChEBI boron oxoanion chebi_ontology boron oxoanions CHEBI:33619 boron oxoanion CHEBI:33619 boron oxoanion ChEBI boron oxoanions ChEBI chebi_ontology polycyclic compounds CHEBI:33635 polycyclic compound CHEBI:33635 polycyclic compounds ChEBI A molecule that features two fused rings. chebi_ontology bicyclic compounds CHEBI:33636 bicyclic compound CHEBI:33636 bicyclic compounds ChEBI A polycyclic compound in which two rings have two, and only two, atoms in common. Such compounds have n common faces and 2n common atoms. chebi_ontology ortho-fused compounds CHEBI:33637 ortho-fused compound CHEBI:33637 ortho-fused compounds ChEBI A polycyclic compound in which one ring contains two, and only two, atoms in common with each of two or more rings of a contiguous series of rings. Such compounds have n common faces and less than 2n common atoms. chebi_ontology ortho- and peri-fused compounds CHEBI:33639 ortho- and peri-fused compound CHEBI:33639 ortho- and peri-fused compounds ChEBI Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds. chebi_ontology CHEBI:33653 aliphatic compound CHEBI:33653 A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character. chebi_ontology aromatics aromatische Verbindungen CHEBI:33655 aromatic compound CHEBI:33655 aromatics ChEBI aromatische Verbindungen ChEBI Any monocyclic or polycyclic aromatic hydrocarbon. chebi_ontology aromatic hydrocarbons CHEBI:33658 arene CHEBI:33658 aromatic hydrocarbons IUPAC chebi_ontology organic aromatic compounds CHEBI:33659 organic aromatic compound CHEBI:33659 organic aromatic compounds ChEBI chebi_ontology monocyclic compounds CHEBI:33661 monocyclic compound CHEBI:33661 monocyclic compounds ChEBI A mancude monocyclic hydrocarbon without side chains of the general formula CnHn (n is an even number) or CnHn+1 (n is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [n]annulene, where n is the number of carbon atoms. chebi_ontology CHEBI:33662 annulene CHEBI:33662 cyclic hydrocarbon chebi_ontology cyclic hydrocarbons CHEBI:33663 cyclic hydrocarbon CHEBI:33663 cyclic hydrocarbon ChEBI cyclic hydrocarbons ChEBI monocyclic hydrocarbon chebi_ontology monocyclic hydrocarbons CHEBI:33664 monocyclic hydrocarbon CHEBI:33664 monocyclic hydrocarbon ChEBI monocyclic hydrocarbons ChEBI chebi_ontology CHEBI:33666 polycyclic hydrocarbon CHEBI:33666 chebi_ontology CHEBI:33670 heteromonocyclic compound CHEBI:33670 A polycyclic compound in which at least one of the rings contains at least one non-carbon atom. chebi_ontology polyheterocyclic compounds CHEBI:33671 heteropolycyclic compound CHEBI:33671 polyheterocyclic compounds ChEBI A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom. chebi_ontology CHEBI:33672 heterobicyclic compound CHEBI:33672 An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element. s-block molecular entity chebi_ontology s-block compounds s-block molecular entities CHEBI:33674 s-block molecular entity CHEBI:33674 s-block molecular entity ChEBI s-block compounds ChEBI s-block molecular entities ChEBI A main group molecular entity that contains one or more atoms of a p-block element. chebi_ontology p-block compounds p-block molecular entities p-block molecular entitiy CHEBI:33675 p-block molecular entity CHEBI:33675 p-block compounds ChEBI p-block molecular entities ChEBI p-block molecular entitiy ChEBI A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element. d-block molecular entity chebi_ontology d-block compounds d-block molecular entities CHEBI:33676 d-block molecular entity CHEBI:33676 d-block molecular entity ChEBI d-block compounds ChEBI d-block molecular entities ChEBI Hydrides are chemical compounds of hydrogen with other chemical elements. chebi_ontology CHEBI:33692 hydrides CHEBI:33692 A macromolecule formed by a living organism. chebi_ontology Biopolymere biomacromolecules biopolymers CHEBI:33694 biomacromolecule CHEBI:33694 Biopolymere ChEBI biomacromolecules ChEBI biopolymers ChEBI chebi_ontology genetically encoded biomacromolecules genetically encoded biopolymers information biomacromolecules information biopolymers information macromolecule information macromolecules CHEBI:33695 information biomacromolecule CHEBI:33695 genetically encoded biomacromolecules ChEBI genetically encoded biopolymers ChEBI information biomacromolecules ChEBI information biopolymers ChEBI information macromolecule ChEBI information macromolecules ChEBI A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid. chebi_ontology NA Nukleinsaeure Nukleinsaeuren acide nucleique acides nucleiques acido nucleico acidos nucleicos CHEBI:33696 nucleic acid CHEBI:33696 NA ChEBI Nukleinsaeure ChEBI Nukleinsaeuren ChEBI acide nucleique ChEBI acides nucleiques ChEBI acido nucleico ChEBI acidos nucleicos ChEBI A cation consisting of more than one atom. chebi_ontology polyatomic cations CHEBI:33702 polyatomic cation CHEBI:33702 polyatomic cations ChEBI chebi_ontology amino acid cation amino acid cations amino-acid cations CHEBI:33703 amino-acid cation CHEBI:33703 amino acid cation ChEBI amino acid cations ChEBI amino-acid cations ChEBI An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group. CHEBI:10208 CHEBI:13779 CHEBI:22442 CHEBI:2642 KEGG:C00045 KEGG:C05167 chebi_ontology Amino acid Amino acids alpha-amino acids alpha-amino carboxylic acids CHEBI:33704 alpha-amino acid CHEBI:33704 Amino acid KEGG_COMPOUND Amino acids KEGG_COMPOUND alpha-amino acids ChEBI alpha-amino acids JCBN alpha-amino carboxylic acids IUPAC When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue. chebi_ontology amino acid residue amino acid residues amino-acid residues CHEBI:33708 amino-acid residue CHEBI:33708 amino acid residue ChEBI amino acid residues ChEBI amino-acid residues JCBN A carboxylic acid containing one or more amino groups. CHEBI:13815 CHEBI:22477 Wikipedia:Amino_acid chebi_ontology Aminocarbonsaeure Aminokarbonsaeure Aminosaeure amino acids CHEBI:33709 amino acid CHEBI:33709 Aminocarbonsaeure ChEBI Aminokarbonsaeure ChEBI Aminosaeure ChEBI amino acids ChEBI chebi_ontology alpha-amino acid cation alpha-amino acid cations alpha-amino-acid cations CHEBI:33719 alpha-amino-acid cation CHEBI:33719 alpha-amino acid cation ChEBI alpha-amino acid cations ChEBI alpha-amino-acid cations ChEBI copper group molecular entity chebi_ontology copper group molecular entities CHEBI:33745 copper group molecular entity CHEBI:33745 copper group molecular entity ChEBI copper group molecular entities ChEBI nickel group molecular entity chebi_ontology nickel group molecular entities CHEBI:33747 nickel group molecular entity CHEBI:33747 nickel group molecular entity ChEBI nickel group molecular entities ChEBI platinum molecular entity chebi_ontology platinum compounds platinum molecular entities CHEBI:33749 platinum molecular entity CHEBI:33749 platinum molecular entity ChEBI platinum compounds ChEBI platinum molecular entities ChEBI chebi_ontology canonical nucleoside residues common nucleoside residues nucleoside residue standard nucleoside residues CHEBI:33791 canonical nucleoside residue CHEBI:33791 canonical nucleoside residues ChEBI common nucleoside residues CBN nucleoside residue CBN standard nucleoside residues ChEBI chebi_ontology canonical deoxyribonucleoside residues common 2'-deoxyribonucleoside residue common 2'-deoxyribonucleoside residues dN dNuc standard deoxyribonucleoside residues CHEBI:33793 canonical deoxyribonucleoside residue CHEBI:33793 canonical deoxyribonucleoside residues ChEBI common 2'-deoxyribonucleoside residue CBN common 2'-deoxyribonucleoside residues CBN dN CBN dNuc CBN standard deoxyribonucleoside residues ChEBI An organic compound having at least one hydroxy group attached to a carbon atom. CHEBI:64710 chebi_ontology organic alcohol organic hydroxy compounds CHEBI:33822 organic hydroxy compound CHEBI:33822 organic alcohol ChEBI organic hydroxy compounds ChEBI Any organic molecule that consists of atoms connected in the form of a ring. chebi_ontology organic cyclic compounds CHEBI:33832 organic cyclic compound CHEBI:33832 organic cyclic compounds ChEBI A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2). chebi_ontology hetarenes CHEBI:33833 heteroarene CHEBI:33833 hetarenes IUPAC chebi_ontology benzenoid aromatic compounds benzenoid compound CHEBI:33836 benzenoid aromatic compound CHEBI:33836 benzenoid aromatic compounds ChEBI benzenoid compound ChEBI An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents. CHEBI:13661 CHEBI:25611 CHEBI:7647 KEGG:C00801 Wikipedia:Nucleoside Nucleoside chebi_ontology a nucleoside nucleosides CHEBI:33838 nucleoside CHEBI:33838 Nucleoside KEGG_COMPOUND a nucleoside UniProt nucleosides ChEBI A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Wikipedia:Macromolecule chebi_ontology macromolecules polymer polymer molecule polymers CHEBI:33839 macromolecule CHEBI:33839 macromolecules ChEBI polymer ChEBI polymer molecule IUPAC polymers ChEBI chebi_ontology aromatic annulenes CHEBI:33842 aromatic annulene CHEBI:33842 aromatic annulenes ChEBI A monocyclic aromatic hydrocarbon. chebi_ontology monocyclic arenes CHEBI:33847 monocyclic arene CHEBI:33847 monocyclic arenes ChEBI A polycyclic aromatic hydrocarbon. Wikipedia:Polycyclic_aromatic_hydrocarbon chebi_ontology PAH PAHs polycyclic arenes polycyclic aromatic hydrocarbons CHEBI:33848 polycyclic arene CHEBI:33848 PAH ChEBI PAHs ChEBI polycyclic arenes ChEBI polycyclic aromatic hydrocarbons ChEBI Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. CHEBI:13664 CHEBI:13825 CHEBI:25969 CHEBI:2857 KEGG:C15584 MetaCyc:Phenols Wikipedia:Phenols chebi_ontology Aryl alcohol a phenol arenols CHEBI:33853 phenols CHEBI:33853 Aryl alcohol KEGG_COMPOUND a phenol UniProt arenols IUPAC An amino acid whose structure includes an aromatic ring. CHEBI:13820 CHEBI:22623 CHEBI:2835 KEGG:C01021 Wikipedia:Aromatic_amino_acid Aromatic amino acid chebi_ontology aromatic amino acids CHEBI:33856 aromatic amino acid CHEBI:33856 Aromatic amino acid KEGG_COMPOUND aromatic amino acids ChEBI Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring. CHEBI:13817 CHEBI:13821 CHEBI:2830 chebi_ontology aromatic carboxylic acids CHEBI:33859 aromatic carboxylic acid CHEBI:33859 aromatic carboxylic acids ChEBI An amino compound in which the amino group is linked directly to an aromatic system. CHEBI:13827 CHEBI:22622 CHEBI:22646 CHEBI:2834 CHEBI:2863 chebi_ontology aromatic amines aryl amine aryl amines arylamine arylamines CHEBI:33860 aromatic amine CHEBI:33860 aromatic amines ChEBI aryl amine ChEBI aryl amines ChEBI arylamine ChEBI arylamines ChEBI chebi_ontology transition element coordination entities transition metal coordination compounds transition metal coordination entities CHEBI:33861 transition element coordination entity CHEBI:33861 transition element coordination entities ChEBI transition metal coordination compounds ChEBI transition metal coordination entities ChEBI platinum coordination entity chebi_ontology platinum coordination compounds platinum coordination entities CHEBI:33862 platinum coordination entity CHEBI:33862 platinum coordination entity ChEBI platinum coordination compounds ChEBI platinum coordination entities ChEBI A substance used in a chemical reaction to detect, measure, examine, or produce other substances. chebi_ontology reactif reactivo reagents CHEBI:33893 reagent CHEBI:33893 reactif IUPAC reactivo IUPAC reagents ChEBI Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals. chebi_ontology macronutrients CHEBI:33937 macronutrient CHEBI:33937 macronutrients ChEBI chebi_ontology halide salts halides CHEBI:33958 halide salt CHEBI:33958 halide salts ChEBI halides ChEBI The diethyl ester of sulfuric acid. Chemspider:5931 HMDB:HMDB0251240 KEGG:C14706 Wikipedia:Diethyl_sulfate chebi_ontology DES Diaethylsulfat Et2SO4 diethyl sulphate diethyl tetraoxosulfate diethylsulfate ethyl sulfate sulfuric acid diethyl ester sulphuric acid diethyl ester CHEBI:34699 diethyl sulfate CHEBI:34699 DES KEGG_COMPOUND Diaethylsulfat ChemIDplus Et2SO4 ChEBI diethyl sulphate ChemIDplus diethyl tetraoxosulfate ChemIDplus diethylsulfate ChemIDplus ethyl sulfate ChEBI sulfuric acid diethyl ester ChemIDplus sulphuric acid diethyl ester NIST_Chemistry_WebBook A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. KEGG:C14422 N-Nitrosodiethylamine chebi_ontology 1,1-diethyl-2-oxohydrazine DANA DEN Diethylnitrosamine N,N-diethylnitrosamine N,N-diethylnitrosoamine NDEA diethylnitrosoamine CHEBI:34873 N-nitrosodiethylamine CHEBI:34873 N-Nitrosodiethylamine KEGG_COMPOUND 1,1-diethyl-2-oxohydrazine NIST_Chemistry_WebBook DANA NIST_Chemistry_WebBook DEN NIST_Chemistry_WebBook Diethylnitrosamine KEGG_COMPOUND N,N-diethylnitrosamine ChemIDplus N,N-diethylnitrosoamine ChemIDplus NDEA KEGG_COMPOUND diethylnitrosoamine ChemIDplus chebi_ontology nitrogen hydrides CHEBI:35106 nitrogen hydride CHEBI:35106 nitrogen hydrides ChEBI Saturated acyclic nitrogen hydrides having the general formula NnHn+2. chebi_ontology azanes CHEBI:35107 azane CHEBI:35107 azanes ChEBI chebi_ontology sulfate salts sulfates sulphate salts sulphates CHEBI:35175 sulfate salt CHEBI:35175 sulfate salts ChEBI sulfates ChEBI sulphate salts ChEBI sulphates ChEBI A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. Wikipedia:Antimetabolite chebi_ontology antimetabolites CHEBI:35221 antimetabolite CHEBI:35221 antimetabolites ChEBI A substance that diminishes the rate of a chemical reaction. chebi_ontology inhibidor inhibiteur inhibitors CHEBI:35222 inhibitor CHEBI:35222 inhibidor ChEBI inhibiteur ChEBI inhibitors ChEBI A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction. chebi_ontology Katalysator catalizador catalyseur CHEBI:35223 catalyst CHEBI:35223 Katalysator ChEBI catalizador ChEBI catalyseur ChEBI cysteine zwitterion chebi_ontology (+)H3N-CH(CH2SH)-COO(-) 2-ammonio-3-mercaptopropanoate CHEBI:35237 cysteine zwitterion CHEBI:35237 cysteine zwitterion IUPAC (+)H3N-CH(CH2SH)-COO(-) ChEBI 2-ammonio-3-mercaptopropanoate ChEBI The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group. chebi_ontology amino acid zwitterion amino acid zwitterions amino-acid zwitterions CHEBI:35238 amino-acid zwitterion CHEBI:35238 amino acid zwitterion ChEBI amino acid zwitterions ChEBI amino-acid zwitterions ChEBI A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc). chebi_ontology ammonium ion derivatives azanium ion derivative azanium ion derivatives CHEBI:35274 ammonium ion derivative CHEBI:35274 ammonium ion derivatives ChEBI azanium ion derivative ChEBI azanium ion derivatives ChEBI Cations of structure R2C=N(+)R2. iminium ion chebi_ontology iminium cations iminium ions CHEBI:35286 iminium ion CHEBI:35286 iminium ion ChEBI iminium cations ChEBI iminium ions ChEBI A polycyclic compound that contains more than one ring with at least two common atoms (also known as bridgehead carbons) that are adjacent to each other. chebi_ontology fused compounds fused polycyclic compounds fused-ring polycyclic compound fused-ring polycyclic compounds polycyclic fused-ring compounds CHEBI:35293 fused compound CHEBI:35293 fused compounds ChEBI fused polycyclic compounds ChEBI fused-ring polycyclic compound ChEBI fused-ring polycyclic compounds ChEBI polycyclic fused-ring compounds ChEBI A polyclic compound in which all of the ring members are carbon atoms. chebi_ontology carbopolycyclic compounds CHEBI:35294 carbopolycyclic compound CHEBI:35294 carbopolycyclic compounds ChEBI chebi_ontology homopolycyclic compounds CHEBI:35295 homopolycyclic compound CHEBI:35295 homopolycyclic compounds ChEBI chebi_ontology ortho-fused polycyclic arenes CHEBI:35296 ortho-fused polycyclic arene CHEBI:35296 ortho-fused polycyclic arenes ChEBI CHEBI:18901 CHEBI:34684 KEGG:C14325 Dibenz[a,h]anthracene chebi_ontology 1,2:5,6-Dibenzanthracene DBA CHEBI:35299 dibenz[a,h]anthracene CHEBI:35299 Dibenz[a,h]anthracene KEGG_COMPOUND 1,2:5,6-Dibenzanthracene KEGG_COMPOUND DBA ChemIDplus chebi_ontology ortho- and peri-fused polycyclic arenes CHEBI:35300 ortho- and peri-fused polycyclic arene CHEBI:35300 ortho- and peri-fused polycyclic arenes ChEBI Any drug that enhances the activity of the central nervous system. Wikipedia:Central_nervous_system_stimulants central nervous system stimulant chebi_ontology CNS stimulant analeptic analeptic agent analeptic drug analeptics central stimulant CHEBI:35337 central nervous system stimulant CHEBI:35337 central nervous system stimulant ChEBI CNS stimulant ChEBI analeptic ChEBI analeptic agent ChEBI analeptic drug ChEBI analeptics ChEBI central stimulant ChEBI Any heteroorganic entity containing at least one carbon-nitrogen bond. chebi_ontology organonitrogens CHEBI:35352 organonitrogen compound CHEBI:35352 organonitrogens ChEBI Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom. KEGG:C06060 chebi_ontology Amidines carboxamidines CHEBI:35359 carboxamidine CHEBI:35359 Amidines KEGG_COMPOUND carboxamidines ChEBI Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids. CHEBI:13633 CHEBI:24024 CHEBI:4984 KEGG:C00162 Wikipedia:Fatty_acid Fatty acid chebi_ontology Fettsaeure Fettsaeuren acide gras acides gras acido graso acidos grasos fatty acids CHEBI:35366 fatty acid CHEBI:35366 Fatty acid KEGG_COMPOUND Fettsaeure ChEBI Fettsaeuren ChEBI acide gras ChEBI acides gras ChemIDplus acido graso ChEBI acidos grasos ChEBI fatty acids ChEBI An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen. CHEBI:33274 CHEBI:33436 oxoanion chebi_ontology oxoacid anions oxoanions CHEBI:35406 oxoanion CHEBI:35406 oxoanion ChEBI oxoacid anions ChEBI oxoanions ChEBI ortho-fused bicyclic arene chebi_ontology ortho-fused bicyclic arenes CHEBI:35426 ortho-fused bicyclic arene CHEBI:35426 ortho-fused bicyclic arene ChEBI ortho-fused bicyclic arenes ChEBI ortho-fused polycyclic hydrocarbon chebi_ontology ortho-fused polycyclic hydrocarbons CHEBI:35427 ortho-fused polycyclic hydrocarbon CHEBI:35427 ortho-fused polycyclic hydrocarbon ChEBI ortho-fused polycyclic hydrocarbons ChEBI ortho-fused bicyclic hydrocarbon chebi_ontology ortho-fused bicyclic hydrocarbons CHEBI:35428 ortho-fused bicyclic hydrocarbon CHEBI:35428 ortho-fused bicyclic hydrocarbon ChEBI ortho-fused bicyclic hydrocarbons ChEBI A substance used in the prophylaxis or therapy of infectious diseases. chebi_ontology anti-infective agents anti-infective drugs antiinfective agents antiinfective drug CHEBI:35441 antiinfective agent CHEBI:35441 anti-infective agents ChEBI anti-infective drugs ChEBI antiinfective agents ChEBI antiinfective drug ChEBI A substance used to treat or prevent parasitic infections. Wikipedia:Antiparasitic chebi_ontology antiparasitic drugs antiparasitics parasiticides CHEBI:35442 antiparasitic agent CHEBI:35442 antiparasitic drugs ChEBI antiparasitics ChEBI parasiticides ChEBI Substance intended to kill parasitic worms (helminths). chebi_ontology anthelminthics anthelmintic anthelmintics antihelminth antihelmintico vermifuge CHEBI:35443 anthelminthic drug CHEBI:35443 anthelminthics ChEBI anthelmintic IUPAC anthelmintics ChEBI antihelminth ChEBI antihelmintico ChEBI vermifuge ChEBI A substance used in the treatment or control of nematode infestations. chebi_ontology antinematodal agent antinematodal drugs antinematodals CHEBI:35444 antinematodal drug CHEBI:35444 antinematodal agent ChEBI antinematodal drugs ChEBI antinematodals ChEBI A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system. chebi_ontology CNS agent CNS drugs central nervous system agents CHEBI:35470 central nervous system drug CHEBI:35470 CNS agent ChEBI CNS drugs ChEBI central nervous system agents ChEBI A loosely defined grouping of drugs that have effects on psychological function. Wikipedia:Psychotropic_drug chebi_ontology psychoactive agent psychoactive drugs psychopharmaceuticals psychotropic drugs CHEBI:35471 psychotropic drug CHEBI:35471 psychoactive agent ChEBI psychoactive drugs ChEBI psychopharmaceuticals ChEBI psychotropic drugs ChEBI chebi_ontology alkali metal salts CHEBI:35479 alkali metal salt CHEBI:35479 alkali metal salts ChEBI An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. chebi_ontology CHEBI:35480 analgesic CHEBI:35480 A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. chebi_ontology CHEBI:35481 non-narcotic analgesic CHEBI:35481 An agent that promotes the excretion of urine through its effects on kidney function. chebi_ontology diuretics CHEBI:35498 diuretic CHEBI:35498 diuretics ChEBI An addition compound contains two or more simpler compounds that can be packed in a definite ratio into a crystal. The term covers donor-acceptor complexes (adducts) and a variety of lattice compounds. chebi_ontology addition compounds CHEBI:35504 addition compound CHEBI:35504 addition compounds ChEBI chebi_ontology heterocyclic fundamental parent heterocyclic organic fundamental parents organic heterocyclic fundamental parents CHEBI:35552 heterocyclic organic fundamental parent CHEBI:35552 heterocyclic fundamental parent ChEBI heterocyclic organic fundamental parents ChEBI organic heterocyclic fundamental parents ChEBI Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds. chebi_ontology mancude rings mancunide-ring systems CHEBI:35568 mancude ring CHEBI:35568 mancude rings ChEBI mancunide-ring systems IUPAC chebi_ontology mancude organic heterobicyclic parents mancude-ring organic heterobicyclic parents CHEBI:35570 mancude organic heterobicyclic parent CHEBI:35570 mancude organic heterobicyclic parents ChEBI mancude-ring organic heterobicyclic parents ChEBI chebi_ontology mancude organic heterocyclic parents mancude-ring organic heterocyclic parents CHEBI:35571 mancude organic heterocyclic parent CHEBI:35571 mancude organic heterocyclic parents ChEBI mancude-ring organic heterocyclic parents ChEBI chebi_ontology organic mancude parents organic mancude-ring parents CHEBI:35573 organic mancude parent CHEBI:35573 organic mancude parents ChEBI organic mancude-ring parents ChEBI A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines. HMDB:HMDB0001366 KEGG:C15587 MetaCyc:PURINE chebi_ontology CHEBI:35584 purine CHEBI:35584 The 1H-tautomer of purine. 1H-purine chebi_ontology CHEBI:35586 1H-purine CHEBI:35586 1H-purine ChEBI The 3H-tautomer of purine. chebi_ontology CHEBI:35588 3H-purine CHEBI:35588 The 9H-tautomer of purine. Wikipedia:Purine 9H-purine chebi_ontology CHEBI:35589 9H-purine CHEBI:35589 9H-purine UniProt A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n. carbon oxoanion chebi_ontology carbon oxoanions oxocarbon anion oxocarbon anions CHEBI:35604 carbon oxoanion CHEBI:35604 carbon oxoanion ChEBI carbon oxoanions ChEBI oxocarbon anion ChEBI oxocarbon anions ChEBI chebi_ontology carbon oxoacids oxoacids of carbon CHEBI:35605 carbon oxoacid CHEBI:35605 carbon oxoacids ChEBI oxoacids of carbon ChEBI A substance that inhibits or prevents the proliferation of neoplasms. chebi_ontology anticancer agent anticancer agents antineoplastic antineoplastic agents cytostatic CHEBI:35610 antineoplastic agent CHEBI:35610 anticancer agent ChEBI anticancer agents ChEBI antineoplastic ChEBI antineoplastic agents ChEBI cytostatic ChEBI Any ether in which the oxygen is attached to at least one aryl substituent. chebi_ontology CHEBI:35618 aromatic ether CHEBI:35618 A member of the class of naphthols carrying a single hydroxy substituent at C-1 or C-2. A closed class. naphthol chebi_ontology hydroxynaphthalene CHEBI:35682 naphthol CHEBI:35682 naphthol IUPAC hydroxynaphthalene ChEBI An agent used to treat cestode, trematode, or other flatworm infestations in man or animals. chebi_ontology antiplatyhelmintic agent antiplatyhelmintic drugs CHEBI:35684 antiplatyhelmintic drug CHEBI:35684 antiplatyhelmintic agent ChEBI antiplatyhelmintic drugs ChEBI Any carboxylic acid containing two carboxy groups. CHEBI:23692 CHEBI:36172 CHEBI:4501 KEGG:C02028 Dicarboxylic acid chebi_ontology dicarboxylic acids CHEBI:35692 dicarboxylic acid CHEBI:35692 Dicarboxylic acid KEGG_COMPOUND dicarboxylic acids ChEBI dicarboxylic acid anion chebi_ontology dicarboxylic acid anions CHEBI:35693 dicarboxylic acid anion CHEBI:35693 dicarboxylic acid anion ChEBI dicarboxylic acid anions ChEBI A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter. CHEBI:23960 CHEBI:4859 KEGG:C00287 Wikipedia:Ester Ester chebi_ontology esters CHEBI:35701 ester CHEBI:35701 Ester KEGG_COMPOUND esters ChEBI An ether in which the oxygen atom is linked to two ethyl groups. CHEBI:23991 CHEBI:31565 KEGG:C13240 KEGG:D01772 Wikipedia:Diethyl_ether Diethyl ether chebi_ontology 1,1'-oxybisethane 3-oxapentane Aether Anesthetic ether Diethylaether Ether Pronarcol R-610 aether aether pro narcosi diethyl oxide ethoxyethane ethyl ether ethyl oxide CHEBI:35702 diethyl ether CHEBI:35702 Diethyl ether KEGG_COMPOUND 1,1'-oxybisethane ChemIDplus 3-oxapentane ChemIDplus Aether ChEBI Anesthetic ether KEGG_COMPOUND Diethylaether ChEBI Ether KEGG_COMPOUND Pronarcol NIST_Chemistry_WebBook R-610 ChEBI aether NIST_Chemistry_WebBook aether pro narcosi ChEBI diethyl oxide ChemIDplus ethoxyethane ChemIDplus ethyl ether ChemIDplus ethyl oxide ChemIDplus A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. CHEBI:10074 CHEBI:27333 KEGG:C06708 Wikipedia:Xenobiotic Xenobiotic chebi_ontology xenobiotic compounds CHEBI:35703 xenobiotic CHEBI:35703 Xenobiotic KEGG_COMPOUND xenobiotic compounds ChEBI An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. chebi_ontology immunosuppressant immunosuppressive agents inmunosupresor CHEBI:35705 immunosuppressive agent CHEBI:35705 immunosuppressant ChEBI immunosuppressive agents ChEBI inmunosupresor ChEBI A compound having a nitro group, -NO2 (free valence on nitrogen), which may be attached to carbon, nitrogen (as in nitramines), or oxygen (as in nitrates), among other elements (in the absence of specification, C-nitro compounds are usually implied). chebi_ontology CHEBI:35715 nitro compound CHEBI:35715 A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated. CHEBI:13657 CHEBI:25382 CHEBI:3407 KEGG:C00060 chebi_ontology Carboxylate Monocarboxylate a monocarboxylate monocarboxylates monocarboxylic acid anions CHEBI:35757 monocarboxylic acid anion CHEBI:35757 Carboxylate KEGG_COMPOUND Monocarboxylate KEGG_COMPOUND a monocarboxylate UniProt monocarboxylates ChEBI monocarboxylic acid anions ChEBI A phosphorus oxoanion that is the conjugate base of phosphoric acid. chebi_ontology Pi phosphate phosphate ions CHEBI:35780 phosphate ion CHEBI:35780 Pi ChEBI phosphate ChEBI phosphate ions ChEBI Compounds having the nitroso group, -NO, attached to carbon, or to another element, most commonly nitrogen or oxygen. chebi_ontology nitroso compounds CHEBI:35800 nitroso compound CHEBI:35800 nitroso compounds ChEBI chebi_ontology -N=O O=N- CHEBI:35801 nitroso group CHEBI:35801 -N=O IUPAC O=N- IUPAC N-Nitroso amines, compounds of the structure R2NNO. Compounds RNHNO are not ordinarily isolable, but they, too, are nitrosamines. The name is a contraction of N-nitrosoamine and, as such, does not require the N locant. Wikipedia:Nitrosamine chebi_ontology N-Nitroso amines nitrosamines CHEBI:35803 nitrosamine CHEBI:35803 N-Nitroso amines IUPAC nitrosamines ChEBI CHEBI:21778 CHEBI:34874 FooDB:FDB003496 HMDB:HMDB0031419 KEGG:C14704 MetaCyc:CPD-18996 PPDB:1645 Wikipedia:N-Nitrosodimethylamine N-Nitrosodimethylamine chebi_ontology 1,1-Dimethyl-2-oxohydrazine DMN Dimethylnitrosamine Dimethylnitrosoamine N,N-Dimethylnitrosamine CHEBI:35807 N-nitrosodimethylamine CHEBI:35807 N-Nitrosodimethylamine ChemIDplus N-Nitrosodimethylamine KEGG_COMPOUND 1,1-Dimethyl-2-oxohydrazine NIST_Chemistry_WebBook DMN ChemIDplus Dimethylnitrosamine KEGG_COMPOUND Dimethylnitrosoamine ChemIDplus N,N-Dimethylnitrosamine ChemIDplus Any antimicrobial drug which is used to treat or prevent protozoal infections. Wikipedia:Antiprotozoal_agent chebi_ontology antiprotozoal agent antiprotozoal agents antiprotozoal drugs CHEBI:35820 antiprotozoal drug CHEBI:35820 antiprotozoal agent ChEBI antiprotozoal agents ChEBI antiprotozoal drugs ChEBI chebi_ontology imidazopyrimidines CHEBI:35875 imidazopyrimidine CHEBI:35875 imidazopyrimidines ChEBI pnictogen hydride chebi_ontology pnictogen hydrides CHEBI:35881 pnictogen hydride CHEBI:35881 pnictogen hydride ChEBI pnictogen hydrides ChEBI A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. chebi_ontology neurotransmitter agents CHEBI:35942 neurotransmitter agent CHEBI:35942 neurotransmitter agents ChEBI A chloroalkane that is ethane in which one or more of the hydrogens is replaced by chlorine. chebi_ontology CHEBI:36016 chloroethanes CHEBI:36016 A drug used to treat or prevent microbial infections. chebi_ontology antimicrobial drugs CHEBI:36043 antimicrobial drug CHEBI:36043 antimicrobial drugs ChEBI A substance used in the prophylaxis or therapy of virus diseases. chebi_ontology anti-viral drug anti-virus drug antiviral drugs CHEBI:36044 antiviral drug CHEBI:36044 anti-viral drug ChEBI anti-virus drug ChEBI antiviral drugs ChEBI chebi_ontology organic chloride salts CHEBI:36094 organic chloride salt CHEBI:36094 organic chloride salts ChEBI Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included). CHEBI:13684 CHEBI:26517 Wikipedia:Quinone quinone chebi_ontology Chinon quinones CHEBI:36141 quinone CHEBI:36141 quinone IUPAC Chinon ChEBI quinones ChEBI A compound in which two monosaccharides are joined by a glycosidic bond. CHEBI:23844 CHEBI:4654 KEGG:C01911 Disaccharide chebi_ontology Disaccharid Disacharid disacarido disacaridos CHEBI:36233 disaccharide CHEBI:36233 Disaccharide KEGG_COMPOUND Disaccharid ChEBI Disacharid ChEBI disacarido ChEBI disacaridos IUPAC chebi_ontology naphthalenesulfonic acids CHEBI:36336 naphthalenesulfonic acid CHEBI:36336 naphthalenesulfonic acids ChEBI Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin). chebi_ontology leptons CHEBI:36338 lepton CHEBI:36338 leptons ChEBI Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). chebi_ontology baryons CHEBI:36339 baryon CHEBI:36339 baryons ChEBI Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi. chebi_ontology fermions CHEBI:36340 fermion CHEBI:36340 fermions ChEBI A particle smaller than an atom. Wikipedia:Subatomic_particle chebi_ontology subatomic particles CHEBI:36342 subatomic particle CHEBI:36342 subatomic particles ChEBI A subatomic particle known to have substructure (i.e. consisting of smaller particles). chebi_ontology composite particles CHEBI:36343 composite particle CHEBI:36343 composite particles ChEBI Hadron is a subatomic particle which experiences the strong force. chebi_ontology hadrons CHEBI:36344 hadron CHEBI:36344 hadrons ChEBI A nucleus or any of its constituents in any of their energy states. chebi_ontology CHEBI:36347 nuclear particle CHEBI:36347 Any molecular entity consisting of more than one atom. chebi_ontology polyatomic entities CHEBI:36357 polyatomic entity CHEBI:36357 polyatomic entities ChEBI An ion consisting of more than one atom. chebi_ontology polyatomic ions CHEBI:36358 polyatomic ion CHEBI:36358 polyatomic ions ChEBI chebi_ontology CHEBI:36360 phosphorus oxoacids and derivatives CHEBI:36360 chebi_ontology saturated heterocyclic parent hydride saturated heterocyclic parent hydrides saturated organic heterocyclic parents CHEBI:36388 saturated organic heterocyclic parent CHEBI:36388 saturated heterocyclic parent hydride ChEBI saturated heterocyclic parent hydrides ChEBI saturated organic heterocyclic parents ChEBI chebi_ontology saturated heteromonocyclic parent hydride saturated heteromonocyclic parent hydrides saturated organic heteromonocyclic parents CHEBI:36389 saturated organic heteromonocyclic parent CHEBI:36389 saturated heteromonocyclic parent hydride ChEBI saturated heteromonocyclic parent hydrides ChEBI saturated organic heteromonocyclic parents ChEBI chebi_ontology mancude organic heterotricyclic parents mancude-ring organic heterotricyclic parents CHEBI:36416 mancude organic heterotricyclic parent CHEBI:36416 mancude organic heterotricyclic parents ChEBI mancude-ring organic heterotricyclic parents ChEBI A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom. Wikipedia:Acridine chebi_ontology 10-azaanthracene 2,3,5,6-dibenzopyridine 2,3-benzoquinoline 9-azaanthracene Akridin acrydine benzo[b]quinoline dibenzo[b,e]pyridine CHEBI:36420 acridine CHEBI:36420 10-azaanthracene ChemIDplus 2,3,5,6-dibenzopyridine ChemIDplus 2,3-benzoquinoline ChemIDplus 9-azaanthracene ChemIDplus Akridin NIST_Chemistry_WebBook acrydine NIST_Chemistry_WebBook benzo[b]quinoline NIST_Chemistry_WebBook dibenzo[b,e]pyridine NIST_Chemistry_WebBook Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives. chebi_ontology CHEBI:36586 carbonyl compound CHEBI:36586 Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element. chebi_ontology organic oxo compounds CHEBI:36587 organic oxo compound CHEBI:36587 organic oxo compounds ChEBI An organochlorine compound is a compound containing at least one carbon-chlorine bond. MetaCyc:Chlorides Wikipedia:Organochloride organochlorine compound chebi_ontology an organochlorine molecule chloroorganic compounds chlororganische Verbindungen organochloride organochloride compound organochloride compounds organochlorides organochlorine compounds CHEBI:36683 organochlorine compound CHEBI:36683 organochlorine compound ChEBI an organochlorine molecule UniProt chloroorganic compounds ChEBI chlororganische Verbindungen ChEBI organochloride ChEBI organochloride compound ChEBI organochloride compounds ChEBI organochlorides ChEBI organochlorine compounds ChEBI heterotricyclic compound chebi_ontology heterotricyclic compounds CHEBI:36688 heterotricyclic compound CHEBI:36688 heterotricyclic compound ChEBI heterotricyclic compounds ChEBI A bicyclic compound in which all the ring atoms are carbon. chebi_ontology carbobicyclic compounds CHEBI:36785 carbobicyclic compound CHEBI:36785 carbobicyclic compounds ChEBI chebi_ontology monoanions CHEBI:36830 monoanion CHEBI:36830 monoanions ChEBI chebi_ontology CHEBI:36892 elemental fluorine CHEBI:36892 chebi_ontology atomic fluorine CHEBI:36895 monoatomic fluorine CHEBI:36895 atomic fluorine ChEBI chebi_ontology inorganic ions CHEBI:36914 inorganic ion CHEBI:36914 inorganic ions ChEBI chebi_ontology inorganic cations CHEBI:36915 inorganic cation CHEBI:36915 inorganic cations ChEBI A monoatomic or polyatomic species having one or more elementary charges of the proton. CHEBI:23058 CHEBI:3473 KEGG:C01373 Cation cation chebi_ontology Kation Kationen cationes cations CHEBI:36916 cation CHEBI:36916 Cation KEGG_COMPOUND cation ChEBI Kation ChEBI Kationen ChEBI cationes ChEBI cations ChEBI chalcocarbonic acid chebi_ontology chalcocarbonic acids CHEBI:36961 chalcocarbonic acid CHEBI:36961 chalcocarbonic acid ChEBI chalcocarbonic acids ChEBI An organochalcogen compound is a compound containing at least one carbon-chalcogen bond. organochalcogen compound chebi_ontology organochalcogen compounds CHEBI:36962 organochalcogen compound CHEBI:36962 organochalcogen compound ChEBI organochalcogen compounds ChEBI An organochalcogen compound containing at least one carbon-oxygen bond. organooxygen compound chebi_ontology organooxygen compounds CHEBI:36963 organooxygen compound CHEBI:36963 organooxygen compound ChEBI organooxygen compounds ChEBI chebi_ontology amino acid anion amino acid anions amino-acid anions CHEBI:37022 amino-acid anion CHEBI:37022 amino acid anion ChEBI amino acid anions ChEBI amino-acid anions ChEBI A compound containing at least one carbon-bromine bond. MetaCyc:Bromide Wikipedia:Organobromine_compound organobromine compound chebi_ontology an organobromine molecule bromoorganic compound organobromide organobromide compound organobromide compounds organobromides organobromine compounds CHEBI:37141 organobromine compound CHEBI:37141 organobromine compound ChEBI an organobromine molecule UniProt bromoorganic compound ChEBI organobromide ChEBI organobromide compound ChEBI organobromide compounds ChEBI organobromides ChEBI organobromine compounds ChEBI An organofluorine compound is a compound containing at least one carbon-fluorine bond. MetaCyc:Fluorides organofluorine compound chebi_ontology fluoroorganic compound fluoroorganic compounds fluoroorganics fluororganische Verbindungen organofluorine compounds CHEBI:37143 organofluorine compound CHEBI:37143 organofluorine compound ChEBI fluoroorganic compound ChEBI fluoroorganic compounds ChEBI fluoroorganics ChEBI fluororganische Verbindungen ChEBI organofluorine compounds ChEBI chebi_ontology organic hydrides CHEBI:37175 organic hydride CHEBI:37175 organic hydrides ChEBI chebi_ontology mononuclear hydride mononuclear hydrides CHEBI:37176 mononuclear parent hydride CHEBI:37176 mononuclear hydride ChEBI mononuclear hydrides IUPAC chebi_ontology CHEBI:37246 elemental sodium CHEBI:37246 A substance administered to enhance contrast in images of the inside of the body obtained using X-rays, gamma-rays, sound waves, radio waves (MRI), or radioactive particles in order to diagnose disease. chebi_ontology CHEBI:37334 diagnostic imaging agent CHEBI:37334 chebi_ontology CHEBI:37335 MRI contrast agent CHEBI:37335 chebi_ontology CHEBI:37404 elemental copper CHEBI:37404 Any ether in which the oxygen atom forms part of a ring. CHEBI:37406 cyclic ether chebi_ontology cyclic ethers epoxy compounds CHEBI:37407 cyclic ether CHEBI:37407 cyclic ether IUPAC cyclic ethers ChEBI epoxy compounds ChEBI A group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid units. CHEBI:24074 CHEBI:24076 chebi_ontology folate folates CHEBI:37445 folic acids CHEBI:37445 folate ChEBI folates ChEBI An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid). CHEBI:13800 CHEBI:13801 CHEBI:22209 CHEBI:2426 KEGG:C00174 Acid chebi_ontology Saeure Saeuren acide acido acids CHEBI:37527 acid CHEBI:37527 Acid KEGG_COMPOUND Saeure ChEBI Saeuren ChEBI acide IUPAC acido ChEBI acids ChEBI A molecular entity consisting of two or more chemical elements. chebi_ontology chemical compound heteroatomic molecular entities CHEBI:37577 heteroatomic molecular entity CHEBI:37577 chemical compound ChEBI heteroatomic molecular entities ChEBI Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements. Wikipedia:Halide chebi_ontology halides CHEBI:37578 halide CHEBI:37578 halides ChEBI chebi_ontology CHEBI:37594 N-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine CHEBI:37594 CHEBI:47635 quinacrine mustard chebi_ontology CHEBI:37595 quinacrine mustard CHEBI:37595 quinacrine mustard ChemIDplus Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR. Wikipedia:Nitrogen_mustard chebi_ontology nitrogen mustard compound nitrogen mustard compounds nitrogen mustards CHEBI:37598 nitrogen mustard CHEBI:37598 nitrogen mustard compound ChEBI nitrogen mustard compounds ChEBI nitrogen mustards ChEBI An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom. CHEBI:35354 CHEBI:35355 chebi_ontology carboxamides primary carboxamide CHEBI:37622 carboxamide CHEBI:37622 carboxamides ChEBI primary carboxamide ChEBI An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases. chebi_ontology protein kinase inhibitors CHEBI:37699 protein kinase inhibitor CHEBI:37699 protein kinase inhibitors ChEBI A straight chain alkane composed of 4 carbon atoms. CHEBI:22945 CHEBI:25462 CHEBI:44430 PDBeChem:NBU Wikipedia:Butane butane chebi_ontology E 943a E-943a E943a N-BUTANE R-600 n-Butan n-C4H10 n-butane CHEBI:37808 butane CHEBI:37808 butane UniProt E 943a ChEBI E-943a ChEBI E943a ChEBI N-BUTANE PDBeChem R-600 ChEBI n-Butan ChEBI n-C4H10 NIST_Chemistry_WebBook n-butane NIST_Chemistry_WebBook sulfuric acid derivative chebi_ontology sulfuric acid derivatives CHEBI:37826 sulfuric acid derivative CHEBI:37826 sulfuric acid derivative ChEBI sulfuric acid derivatives ChEBI A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid. chebi_ontology carboxylic acyl groups CHEBI:37838 carboacyl group CHEBI:37838 carboxylic acyl groups IUPAC chebi_ontology azacycloalkanes CHEBI:37949 azacycloalkane CHEBI:37949 azacycloalkanes ChEBI chebi_ontology Farbstoff Farbstoffe colorante colorantes dyes teinture teintures CHEBI:37958 dye CHEBI:37958 Farbstoff ChEBI Farbstoffe ChEBI colorante ChEBI colorantes ChEBI dyes ChEBI teinture ChEBI teintures ChEBI The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days. KEGG:C19162 chebi_ontology (32)15P (32)P Phosphorus, isotope of mass 32 phosphorus, isotope of mass 32 phosphorus-32 CHEBI:37972 phosphorus-32 atom CHEBI:37972 (32)15P IUPAC (32)P IUPAC Phosphorus, isotope of mass 32 KEGG_COMPOUND phosphorus, isotope of mass 32 ChemIDplus phosphorus-32 ChEBI A carbopolyclic compound comprising of three carbocyclic rings. chebi_ontology carbotricyclic compounds CHEBI:38032 carbotricyclic compound CHEBI:38032 carbotricyclic compounds ChEBI chebi_ontology aminonaphthalenes CHEBI:38034 aminonaphthalene CHEBI:38034 aminonaphthalenes ChEBI chebi_ontology mesylate salt mesylate salts methanesulfonate salts CHEBI:38037 methanesulfonate salt CHEBI:38037 mesylate salt ChEBI mesylate salts ChEBI methanesulfonate salts ChEBI A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. chebi_ontology antimalarials CHEBI:38068 antimalarial CHEBI:38068 antimalarials ChEBI Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms. chebi_ontology heterocyclic organonitrogen compounds organonitrogen heterocyclic compounds CHEBI:38101 organonitrogen heterocyclic compound CHEBI:38101 heterocyclic organonitrogen compounds ChEBI organonitrogen heterocyclic compounds ChEBI Compounds based on a triazine skeleton. chebi_ontology CHEBI:38102 triazines CHEBI:38102 Any organic heterocyclic compound containing at least one ring oxygen atom. chebi_ontology heterocyclic organooxygen compounds organooxygen heterocyclic compounds oxacycles CHEBI:38104 oxacycle CHEBI:38104 heterocyclic organooxygen compounds ChEBI organooxygen heterocyclic compounds ChEBI oxacycles ChEBI chebi_ontology heterocyclic organosulfur compounds organosulfur heterocyclic compounds CHEBI:38106 organosulfur heterocyclic compound CHEBI:38106 heterocyclic organosulfur compounds ChEBI organosulfur heterocyclic compounds ChEBI chebi_ontology organic heterotetracyclic compounds CHEBI:38163 organic heterotetracyclic compound CHEBI:38163 organic heterotetracyclic compounds ChEBI CHEBI:25429 CHEBI:38075 chebi_ontology organic heteropolycyclic compounds CHEBI:38166 organic heteropolycyclic compound CHEBI:38166 organic heteropolycyclic compounds ChEBI chebi_ontology triamino-1,3,5-triazines CHEBI:38175 triamino-1,3,5-triazine CHEBI:38175 triamino-1,3,5-triazines ChEBI chebi_ontology polycyclic heteroarenes CHEBI:38180 polycyclic heteroarene CHEBI:38180 polycyclic heteroarenes ChEBI Any inhibitor of a DNA polymerase. chebi_ontology CHEBI:38234 DNA polymerase inhibitor CHEBI:38234 chebi_ontology azirinopyrroloindoles CHEBI:38303 azirinopyrroloindole CHEBI:38303 azirinopyrroloindoles ChEBI Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure). chebi_ontology CHEBI:38313 diazines CHEBI:38313 Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. chebi_ontology cholinergic agent cholinergic drugs cholinomimetic CHEBI:38323 cholinergic drug CHEBI:38323 cholinergic agent ChEBI cholinergic drugs ChEBI cholinomimetic ChEBI A pyrimidine carrying one or more oxo substituents. chebi_ontology pyrimidones CHEBI:38337 pyrimidone CHEBI:38337 pyrimidones ChEBI chebi_ontology 1-benzopyrans CHEBI:38443 1-benzopyran CHEBI:38443 1-benzopyrans ChEBI A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family. chebi_ontology benzophenanthridine alkaloids CHEBI:38517 benzophenanthridine alkaloid CHEBI:38517 benzophenanthridine alkaloids ChEBI chebi_ontology benzophenanthridines CHEBI:38518 benzophenanthridine CHEBI:38518 benzophenanthridines ChEBI Any agent that affects the transport of molecular entities across a biological membrane. chebi_ontology membrane transport modulators CHEBI:38632 membrane transport modulator CHEBI:38632 membrane transport modulators ChEBI Any flavonoid with a 3,4-dihydro-2-aryl-2H-1-benzopyran skeleton and its substituted derivatives. chebi_ontology CHEBI:38672 flavans CHEBI:38672 chebi_ontology inorganic sodium salts CHEBI:38702 inorganic sodium salt CHEBI:38702 inorganic sodium salts ChEBI Any dianion containing at least one carboxy group. carboxylic acid dianion chebi_ontology carboxylic acid dianions CHEBI:38716 carboxylic acid dianion CHEBI:38716 carboxylic acid dianion ChEBI carboxylic acid dianions ChEBI Any methoxyflavanone that is flavanone substituted by a methoxy group. chebi_ontology monomethoxyflavanones CHEBI:38738 monomethoxyflavanone CHEBI:38738 monomethoxyflavanones ChEBI A hydroxyflavanone carrying three hydroxy substituents. chebi_ontology trihydroxyflavanones CHEBI:38739 trihydroxyflavanone CHEBI:38739 trihydroxyflavanones ChEBI Any hydroxyflavanone carrying two hydroxy substituents. chebi_ontology dihydroxyflavanones CHEBI:38749 dihydroxyflavanone CHEBI:38749 dihydroxyflavanones ChEBI A compound having the nitro group (-NO2) attached to a nitrogen atom. chebi_ontology CHEBI:38780 N-nitro compound CHEBI:38780 CHEBI:37074 chebi_ontology CHEBI:38793 pteroate CHEBI:38793 CHEBI:26378 DrugBank:DB04196 Pteroic acid chebi_ontology Pteroinsaeure CHEBI:38794 pteroic acid CHEBI:38794 Pteroic acid ChemIDplus Pteroinsaeure ChEBI chebi_ontology CHEBI:38795 pteroic acids CHEBI:38795 chebi_ontology CHEBI:38796 pteroates CHEBI:38796 A membrane transport modulator that is able to regulate intracellular calcium levels. chebi_ontology calcium channel modulators CHEBI:38808 calcium channel modulator CHEBI:38808 calcium channel modulators ChEBI chebi_ontology RyR modulator ryanodine receptor modulators ryanodine-sensitive calcium channel modulator ryanodine-sensitive calcium-release channel modulator CHEBI:38809 ryanodine receptor modulator CHEBI:38809 RyR modulator ChEBI ryanodine receptor modulators ChEBI ryanodine-sensitive calcium channel modulator ChEBI ryanodine-sensitive calcium-release channel modulator ChEBI Substance which produces loss of feeling or sensation. chebi_ontology Anaesthetika Anaesthetikum anaesthetics anesthetic agent anesthetic drug anesthetics CHEBI:38867 anaesthetic CHEBI:38867 Anaesthetika ChEBI Anaesthetikum ChEBI anaesthetics ChEBI anesthetic agent ChEBI anesthetic drug ChEBI anesthetics ChEBI Substance that produces loss of consciousness. chebi_ontology Allgemeinanaesthetika Allgemeinanaesthetikum general anaesthetics general anesthetics CHEBI:38869 general anaesthetic CHEBI:38869 Allgemeinanaesthetika ChEBI Allgemeinanaesthetikum ChEBI general anaesthetics ChEBI general anesthetics ChEBI chebi_ontology Inhalationsanaesthetika Inhalationsanaesthetikum Inhalationsnarkotika Inhalationsnarkotikum anesthetic gases inhalation anesthetics CHEBI:38870 inhalation anaesthetic CHEBI:38870 Inhalationsanaesthetika ChEBI Inhalationsanaesthetikum ChEBI Inhalationsnarkotika ChEBI Inhalationsnarkotikum ChEBI anesthetic gases ChEBI inhalation anesthetics ChEBI Drugs that used to treat infestations by flukes (trematodes) of the genus Schistosoma. chebi_ontology antischistosoma antischistosomal drug schistosomicide schistosomicide drugs schistosomicides CHEBI:38941 schistosomicide drug CHEBI:38941 antischistosoma ChEBI antischistosomal drug ChEBI schistosomicide ChEBI schistosomicide drugs ChEBI schistosomicides ChEBI Any alkylbenzene that is benzene substituted with one or more methyl groups. chebi_ontology methylbenzenes CHEBI:38975 methylbenzene CHEBI:38975 methylbenzenes ChEBI A monocyclic arene that is benzene substituted with one or more alkyl groups. alkylbenzene chebi_ontology Alkylbenzol alkylbenzenes CHEBI:38976 alkylbenzene CHEBI:38976 alkylbenzene ChEBI Alkylbenzol ChEBI alkylbenzenes ChEBI Any sulfur oxoacid derivative derived from sulfurous acid. sulfurous acid derivative chebi_ontology CHEBI:39087 sulfurous acid derivative CHEBI:39087 sulfurous acid derivative ChEBI A molecular entity capable of donating a hydron to an acceptor (Bronsted base). chebi_ontology Bronsted-Saeure acide de Bronsted donneur d'hydron hydron donor CHEBI:39141 Bronsted acid CHEBI:39141 Bronsted-Saeure ChEBI acide de Bronsted IUPAC donneur d'hydron IUPAC hydron donor IUPAC A molecular entity capable of accepting a hydron from a donor (Bronsted acid). chebi_ontology Bronsted-Base accepteur d'hydron base de Bronsted hydron acceptor CHEBI:39142 Bronsted base CHEBI:39142 Bronsted-Base ChEBI accepteur d'hydron IUPAC base de Bronsted IUPAC hydron acceptor IUPAC A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct. chebi_ontology Lewis-Base base de Lewis donneur d'une paire d'electrons electron donor CHEBI:39144 Lewis base CHEBI:39144 Lewis-Base ChEBI base de Lewis IUPAC donneur d'une paire d'electrons ChEBI electron donor ChEBI An N-nitro compound that is guanidine in which one of the hydrogens is replaced by a nitro group. It can exist in distinct tautomeric forms, as 1-nitroguanidine (a nitroimine) or 2-nitroguanidine (a nitroamine); in both solid and in solution, the nitroimine form predominates. Wikipedia:Nitroguanidine chebi_ontology picrite CHEBI:39179 nitroguanidine CHEBI:39179 picrite NIST_Chemistry_WebBook Any organonitrogen heterocyclic compound based on a phenazine skeleton and derivatives. chebi_ontology CHEBI:39201 phenazines CHEBI:39201 chebi_ontology dibenzopyridines CHEBI:39206 dibenzopyridine CHEBI:39206 dibenzopyridines ChEBI A volatile or volatilizable chemical compound utilized for control of pests in buildings, soil, grain, as well as during processing of goods to be imported or exported to prevent transfer of exotic organisms. Wikipedia:Fumigation chebi_ontology fumigant pesticide fumigants CHEBI:39276 fumigant CHEBI:39276 fumigant pesticide ChEBI fumigants ChEBI Any saturated fatty acid lacking a side-chain. straight-chain saturated fatty acid chebi_ontology straight-chain saturated fatty acids CHEBI:39418 straight-chain saturated fatty acid CHEBI:39418 straight-chain saturated fatty acid ChEBI straight-chain saturated fatty acids ChEBI CHEBI:13784 CHEBI:26445 CHEBI:7263 chebi_ontology CHEBI:39446 pyrimidine ribonucleosides CHEBI:39446 Any compound having a pyrimidine as part of its structure. CHEBI:13681 CHEBI:26448 chebi_ontology CHEBI:39447 pyrimidines CHEBI:39447 A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated. CHEBI:29137 CHEBI:39739 DrugBank:DB02831 PDBeChem:2HP chebi_ontology DIHYDROGENPHOSPHATE ION H2PO4(-) [PO2(OH)2](-) CHEBI:39745 dihydrogenphosphate CHEBI:39745 DIHYDROGENPHOSPHATE ION PDBeChem H2PO4(-) IUPAC [PO2(OH)2](-) IUPAC KEGG:C02019 Cyclic ketone chebi_ontology CHEBI:3992 cyclic ketone CHEBI:3992 Cyclic ketone KEGG_COMPOUND A butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p. 16degreeC) with a high boiling point (230degreeC), it is mainly used for the production of other organic chemicals, particularly the solvent oxolane (also known as tetrahydrofuran or THF). DrugBank:DB01955 PDBeChem:BU1 Wikipedia:1,4-Butanediol chebi_ontology 1,4-BD 1,4-BUTANEDIOL 1,4-butylene glycol 1,4-dihydroxybutane 1,4-tetramethylene glycol HO(CH2)4OH HOCH2CH2CH2CH2OH tetramethylene 1,4-diol tetramethylene glycol CHEBI:41189 butane-1,4-diol CHEBI:41189 1,4-BD ChemIDplus 1,4-BUTANEDIOL PDBeChem 1,4-butylene glycol ChemIDplus 1,4-dihydroxybutane ChemIDplus 1,4-tetramethylene glycol ChemIDplus HO(CH2)4OH ChEBI HOCH2CH2CH2CH2OH ChEBI tetramethylene 1,4-diol ChemIDplus tetramethylene glycol ChemIDplus CHEBI:29201 CHEBI:41605 PDBeChem:CO3 carbonate chebi_ontology CARBONATE ION CO3(2-) Karbonat [CO3](2-) CHEBI:41609 carbonate CHEBI:41609 carbonate IUPAC CARBONATE ION PDBeChem CO3(2-) ChEBI Karbonat ChEBI [CO3](2-) IUPAC An alkane comprising of two carbon atoms. CHEBI:23975 CHEBI:42260 Wikipedia:Ethane ETHANE ethane chebi_ontology Aethan C2H6 CH3-CH3 Ethan R-170 bimethyl dimethyl ethyl hydride methylmethane CHEBI:42266 ethane CHEBI:42266 ETHANE PDBeChem ethane UniProt Aethan ChEBI C2H6 ChEBI CH3-CH3 IUPAC Ethan ChEBI R-170 ChEBI bimethyl NIST_Chemistry_WebBook dimethyl NIST_Chemistry_WebBook ethyl hydride NIST_Chemistry_WebBook methylmethane NIST_Chemistry_WebBook CHEBI:24089 CHEBI:42480 PDBeChem:FOR FORMYL GROUP chebi_ontology -CH(O) -CHO Fo H-CO- methanoyl CHEBI:42485 formyl group CHEBI:42485 FORMYL GROUP PDBeChem -CH(O) IUPAC -CHO IUPAC Fo CBN H-CO- IUPAC methanoyl IUPAC An aminocarboxamidine, the parent compound of the guanidines. CHEBI:24435 CHEBI:42816 DrugBank:DB00536 PDBeChem:GAI Wikipedia:Guanidine GUANIDINE chebi_ontology Gu H2N-C(=NH)-NH2 aminomethanamidine guanidin iminourea CHEBI:42820 guanidine CHEBI:42820 GUANIDINE PDBeChem Gu ChEBI H2N-C(=NH)-NH2 IUPAC aminomethanamidine NIST_Chemistry_WebBook guanidin ChEBI iminourea NIST_Chemistry_WebBook CHEBI:24706 CHEBI:43171 PDBeChem:OH HYDROXY GROUP hydroxy group chebi_ontology -OH hydroxyl hydroxyl group CHEBI:43176 hydroxy group CHEBI:43176 HYDROXY GROUP PDBeChem hydroxy group UniProt -OH IUPAC hydroxyl ChEBI hydroxyl group ChEBI chebi_ontology CHEBI:43254 (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one CHEBI:43254 A phosphate ion that is the conjugate base of dihydrogenphosphate. CHEBI:29139 CHEBI:43470 MolBase:1628 PDBeChem:PI PDBeChem:PO4 chebi_ontology HPO4(2-) HYDROGENPHOSPHATE ION INORGANIC PHOSPHATE GROUP [P(OH)O3](2-) [PO3(OH)](2-) hydrogen phosphate phosphate CHEBI:43474 hydrogenphosphate CHEBI:43474 HPO4(2-) IUPAC HYDROGENPHOSPHATE ION PDBeChem INORGANIC PHOSPHATE GROUP PDBeChem [P(OH)O3](2-) MolBase [PO3(OH)](2-) IUPAC hydrogen phosphate ChEBI phosphate UniProt CHEBI:29199 CHEBI:45693 hydrogensulfate chebi_ontology HSO4(-) HYDROGEN SULFATE [SO3(OH)](-) CHEBI:45696 hydrogensulfate CHEBI:45696 hydrogensulfate IUPAC HSO4(-) IUPAC HYDROGEN SULFATE PDBeChem [SO3(OH)](-) IUPAC CHEBI:29353 CHEBI:44607 PDBeChem:O OXO GROUP chebi_ontology =O CHEBI:46629 oxo group CHEBI:46629 OXO GROUP PDBeChem =O IUPAC A liquid that can dissolve other substances (solutes) without any change in their chemical composition. Wikipedia:Solvent chebi_ontology Loesungsmittel solvant solvents CHEBI:46787 solvent CHEBI:46787 Loesungsmittel ChEBI solvant ChEBI solvents ChEBI Any ether carrying a hydroxy group at unspecified position. hydroxyether chebi_ontology CHEBI:46789 hydroxyether CHEBI:46789 hydroxyether ChEBI A hydroxyether that is ethanol substituted by a methoxy group at position 2. CHEBI:19677 CHEBI:44217 DrugBank:DB02806 MetaCyc:2-METHOXYETHANOL PDBeChem:MXE PPDB:1639 Wikipedia:2-Methoxyethanol 2-METHOXYETHANOL chebi_ontology 1-hydroxy-2-methoxyethane 2-hydroxyethyl methyl ether 2-methoxy-1-ethanol 3-oxa-1-butanol HOCH2CH2OCH3 Methyl cellosolve beta-methoxyethanol methyl oxitol monomethyl ethylene glycol ether CHEBI:46790 2-methoxyethanol CHEBI:46790 2-METHOXYETHANOL PDBeChem 1-hydroxy-2-methoxyethane ChemIDplus 2-hydroxyethyl methyl ether NIST_Chemistry_WebBook 2-methoxy-1-ethanol ChemIDplus 3-oxa-1-butanol ChemIDplus HOCH2CH2OCH3 NIST_Chemistry_WebBook Methyl cellosolve ChemIDplus beta-methoxyethanol NIST_Chemistry_WebBook methyl oxitol ChemIDplus monomethyl ethylene glycol ether ChemIDplus CHEBI:23025 CHEBI:41420 PDBeChem:FMT CARBOXY GROUP chebi_ontology -C(O)OH -CO2H -COOH carboxyl group CHEBI:46883 carboxy group CHEBI:46883 CARBOXY GROUP PDBeChem -C(O)OH IUPAC -CO2H ChEBI -COOH IUPAC carboxyl group ChEBI chebi_ontology tetrahydrofuranols CHEBI:47017 tetrahydrofuranol CHEBI:47017 tetrahydrofuranols ChEBI chebi_ontology monohydroxytetrahydrofurans CHEBI:47018 monohydroxytetrahydrofuran CHEBI:47018 monohydroxytetrahydrofurans ChEBI chebi_ontology dihydroxytetrahydrofurans CHEBI:47019 dihydroxytetrahydrofuran CHEBI:47019 dihydroxytetrahydrofurans ChEBI CHEBI:27220 CHEBI:36947 chebi_ontology urea derivatives CHEBI:47857 ureas CHEBI:47857 urea derivatives ChEBI A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells. chebi_ontology photosensitising agent CHEBI:47868 photosensitizing agent CHEBI:47868 photosensitising agent ChEBI Organic derivatives of sulfonic acid in which the sulfo group is linked directly to carbon of an alkyl group. CHEBI:13809 CHEBI:33553 chebi_ontology alkanesulfonic acids alkylsulfonic acids CHEBI:47901 alkanesulfonic acid CHEBI:47901 alkanesulfonic acids ChEBI alkylsulfonic acids ChEBI Any member of the 'superclass' flavonoids whose skeleton is based on 1-benzopyran with an aryl substituent at position 2. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds. CHEBI:13638 CHEBI:24044 CHEBI:5077 KEGG:C01579 Wikipedia:Flavonoid Flavonoid chebi_ontology 2-aryl-1-benzopyran 2-aryl-1-benzopyrans flavonoids CHEBI:47916 flavonoid CHEBI:47916 Flavonoid KEGG_COMPOUND 2-aryl-1-benzopyran ChEBI 2-aryl-1-benzopyrans ChEBI flavonoids ChEBI Any hydroxyflavanone with a hydroxy substituent at position 3' of the phenyl ring. MetaCyc:3-Hydroxy-Flavanones chebi_ontology CHEBI:48024 3'-hydroxyflavanones CHEBI:48024 chebi_ontology Schwefeloxide oxides of sulfur sulfur oxides CHEBI:48154 sulfur oxide CHEBI:48154 Schwefeloxide ChEBI oxides of sulfur ChEBI sulfur oxides ChEBI An antimicrobial agent that is applied to non-living objects to destroy harmful microorganisms or to inhibit their activity. chebi_ontology Desinfektionsmittel desinfectant disinfectants disinfecting agent CHEBI:48219 disinfectant CHEBI:48219 Desinfektionsmittel ChEBI desinfectant ChEBI disinfectants ChEBI disinfecting agent ChEBI A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds. chebi_ontology polar solvents CHEBI:48354 polar solvent CHEBI:48354 polar solvents ChEBI chebi_ontology CHEBI:48355 non-polar solvent CHEBI:48355 A polar solvent that is capable of acting as a hydron (proton) donor. chebi_ontology CHEBI:48356 protic solvent CHEBI:48356 chebi_ontology CHEBI:48357 aprotic solvent CHEBI:48357 A solvent with a comparatively high relative permittivity (or dielectric constant), greater than ca. 15, and a sizable permanent dipole moment, that cannot donate suitably labile hydrogen atoms to form strong hydrogen bonds. chebi_ontology CHEBI:48358 polar aprotic solvent CHEBI:48358 chebi_ontology H2N-C(=NH)-OH H2N-C(OH)=NH HO-C(=NH)-NH2 Isoharnstoff carbamimic acid carbonamidimidic acid isourea pseudourea CHEBI:48376 carbamimidic acid CHEBI:48376 H2N-C(=NH)-OH IUPAC H2N-C(OH)=NH IUPAC HO-C(=NH)-NH2 IUPAC Isoharnstoff ChEBI carbamimic acid ChemIDplus carbonamidimidic acid IUPAC isourea ChemIDplus pseudourea ChemIDplus Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing =O by =NR; thus tautomers of amides. In organic chemistry an unspecified imidic acid is generally a carboximidic acid, RC(=NR)(OH). imidic acid chebi_ontology imidic acids imino acids CHEBI:48377 imidic acid CHEBI:48377 imidic acid ChEBI imidic acids ChEBI imino acids IUPAC carboximidic acid chebi_ontology carboximidic acids CHEBI:48378 carboximidic acid CHEBI:48378 carboximidic acid ChEBI carboximidic acids ChEBI A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives. chebi_ontology isoureas CHEBI:48379 isourea CHEBI:48379 isoureas ChEBI Esters or salts of methanesulfonic acid. chebi_ontology CHEBI:48544 methanesulfonates CHEBI:48544 A role played by a substance that can react readily with, and thereby eliminate, radicals. chebi_ontology free radical scavengers free-radical scavenger CHEBI:48578 radical scavenger CHEBI:48578 free radical scavengers ChEBI free-radical scavenger ChEBI Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances. chebi_ontology antagonista antagoniste antagonists CHEBI:48706 antagonist CHEBI:48706 antagonista ChEBI antagoniste ChEBI antagonists ChEBI CHEBI:26837 CHEBI:9344 KEGG:C00094 KNApSAcK:C00019662 PDBeChem:SO3 Sulfurous acid chebi_ontology H2SO3 S(O)(OH)2 Sulfite [SO(OH)2] acide sulfureux acido sulfuroso schweflige Saeure sulphurous acid CHEBI:48854 sulfurous acid CHEBI:48854 Sulfurous acid KEGG_COMPOUND H2SO3 IUPAC S(O)(OH)2 IUPAC Sulfite KEGG_COMPOUND [SO(OH)2] IUPAC acide sulfureux ChEBI acido sulfuroso ChEBI schweflige Saeure ChemIDplus sulphurous acid ChemIDplus chebi_ontology CHEBI:48857 sulfite salt CHEBI:48857 Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. chebi_ontology Anticholinergika Anticholinergikum acetylcholine antagonists acetylcholine receptor antagonist agent anticholinergique agente anticolinergico agentes anticolinergicos anticholinergic agents anticholinergics anticholinergiques anticolinergicos cholinergic-blocking agents CHEBI:48873 cholinergic antagonist CHEBI:48873 Anticholinergika ChEBI Anticholinergikum ChEBI acetylcholine antagonists ChEBI acetylcholine receptor antagonist IUPHAR agent anticholinergique ChEBI agente anticolinergico ChEBI agentes anticolinergicos ChEBI anticholinergic agents ChEBI anticholinergics ChEBI anticholinergiques ChEBI anticolinergicos ChEBI cholinergic-blocking agents ChEBI Any L-alpha-amino acid carrying an N-acyl substituent. CHEBI:13240 CHEBI:7232 KEGG:C02850 chebi_ontology N-Acyl-L-amino acid CHEBI:48927 N-acyl-L-alpha-amino acid CHEBI:48927 N-Acyl-L-amino acid KEGG_COMPOUND CHEBI:24634 CHEBI:49636 WebElements:H chebi_ontology 1H H Wasserstoff hidrogeno hydrogen hydrogene CHEBI:49637 hydrogen atom CHEBI:49637 1H IUPAC H IUPAC Wasserstoff ChEBI hidrogeno ChEBI hydrogen ChEBI hydrogene ChEBI A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups. chebi_ontology organic amino compounds CHEBI:50047 organic amino compound CHEBI:50047 organic amino compounds ChEBI A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups. CHEBI:25565 CHEBI:34843 CHEBI:50101 KEGG:C14595 Wikipedia:N-Methyl-N-nitrosourea N-Methyl-N-nitrosourea chebi_ontology 1-(aminocarbonyl)-1-methyl-2-oxohydrazine 1-nitroso-1-methylurea MNU Methylnitrosoharnstoff Methylnitrosourea N-Methyl-N-nitrosoharnstoff N-Nitroso-N-methylharnstoff N-methyl-N-nitrosocarbamide N-methyl-N-nitrosouree N-nitroso-N-methylcarbamide N-nitroso-N-methylurea N-nitroso-N-methyluree N-nitrosomethylurea NMH NMU methylnitrosouree nitrosomethylurea CHEBI:50102 N-methyl-N-nitrosourea CHEBI:50102 N-Methyl-N-nitrosourea KEGG_COMPOUND 1-(aminocarbonyl)-1-methyl-2-oxohydrazine NIST_Chemistry_WebBook 1-nitroso-1-methylurea ChemIDplus MNU ChemIDplus Methylnitrosoharnstoff ChEBI Methylnitrosourea KEGG_COMPOUND N-Methyl-N-nitrosoharnstoff ChEBI N-Nitroso-N-methylharnstoff ChEBI N-methyl-N-nitrosocarbamide ChemIDplus N-methyl-N-nitrosouree ChEBI N-nitroso-N-methylcarbamide NIST_Chemistry_WebBook N-nitroso-N-methylurea ChemIDplus N-nitroso-N-methyluree ChEBI N-nitrosomethylurea NIST_Chemistry_WebBook NMH ChemIDplus NMU ChemIDplus methylnitrosouree ChemIDplus nitrosomethylurea NIST_Chemistry_WebBook An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a phosphoric diester hydrolase (EC 3.1.4.*). CHEBI:76774 chebi_ontology EC 3.1.4.* (phosphoric diester hydrolase) inhibitors phosphodiesterase inhibitor phosphodiesterase inhibitors phosphoric diester hydrolase (EC 3.1.4.*) inhibitor phosphoric diester hydrolase (EC 3.1.4.*) inhibitors phosphoric diester hydrolase inhibitor phosphoric diester hydrolase inhibitors CHEBI:50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitor CHEBI:50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitors ChEBI phosphodiesterase inhibitor ChEBI phosphodiesterase inhibitors ChEBI phosphoric diester hydrolase (EC 3.1.4.*) inhibitor ChEBI phosphoric diester hydrolase (EC 3.1.4.*) inhibitors ChEBI phosphoric diester hydrolase inhibitor ChEBI phosphoric diester hydrolase inhibitors ChEBI Any protective agent counteracting or neutralizing the action of poisons. chebi_ontology antidotes CHEBI:50247 antidote CHEBI:50247 antidotes ChEBI A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. Wikipedia:Prodrug chebi_ontology Prodrugs CHEBI:50266 prodrug CHEBI:50266 Prodrugs ChEBI Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. chebi_ontology chemoprotectant chemoprotectants chemoprotective agent chemoprotective agents protective agents CHEBI:50267 protective agent CHEBI:50267 chemoprotectant ChEBI chemoprotectants ChEBI chemoprotective agent ChEBI chemoprotective agents ChEBI protective agents ChEBI A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. chebi_ontology DNA topoisomerase inhibitor DNA topoisomerase inhibitors EC 5.99.1.2 (DNA topoisomerase) inhibitors EC 5.99.1.2 (topoisomerase I) inhibitor EC 5.99.1.2 (topoisomerase I) inhibitors EC 5.99.1.2 inhibitor EC 5.99.1.2 inhibitors topoisomerase I (EC 5.99.1.2) inhibitor topoisomerase I (EC 5.99.1.2) inhibitors topoisomerase I inhibitor topoisomerase I inhibitors type I DNA topoisomerase inhibitor type I DNA topoisomerase inhibitors CHEBI:50276 EC 5.99.1.2 (DNA topoisomerase) inhibitor CHEBI:50276 DNA topoisomerase inhibitor ChEBI DNA topoisomerase inhibitors ChEBI EC 5.99.1.2 (DNA topoisomerase) inhibitors ChEBI EC 5.99.1.2 (topoisomerase I) inhibitor ChEBI EC 5.99.1.2 (topoisomerase I) inhibitors ChEBI EC 5.99.1.2 inhibitor ChEBI EC 5.99.1.2 inhibitors ChEBI topoisomerase I (EC 5.99.1.2) inhibitor ChEBI topoisomerase I (EC 5.99.1.2) inhibitors ChEBI topoisomerase I inhibitor ChEBI topoisomerase I inhibitors ChEBI type I DNA topoisomerase inhibitor ChEBI type I DNA topoisomerase inhibitors ChEBI chebi_ontology canonical nucleotide residues CHEBI:50297 canonical nucleotide residue CHEBI:50297 canonical nucleotide residues ChEBI chebi_ontology canonical deoxyribonucleotide residues CHEBI:50298 canonical deoxyribonucleotide residue CHEBI:50298 canonical deoxyribonucleotide residues ChEBI chebi_ontology CHEBI:50312 onium compound CHEBI:50312 Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families. chebi_ontology onium cations onium ion onium ions CHEBI:50313 onium cation CHEBI:50313 onium cations ChEBI onium ion ChEBI onium ions ChEBI chebi_ontology H2F(+) [FH2](+) CHEBI:50314 fluoronium CHEBI:50314 H2F(+) IUPAC [FH2](+) ChEBI chebi_ontology H2Cl(+) [ClH2](+) CHEBI:50315 chloronium CHEBI:50315 H2Cl(+) IUPAC [ClH2](+) IUPAC chebi_ontology nucleotide residues CHEBI:50319 nucleotide residue CHEBI:50319 nucleotide residues ChEBI chebi_ontology nucleoside residues CHEBI:50320 nucleoside residue CHEBI:50320 nucleoside residues ChEBI A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid. chebi_ontology canonical amino-acid side-chain canonical amino-acid side-chains proteinogenic amino-acid side-chain proteinogenic amino-acid side-chain groups proteinogenic amino-acid side-chains CHEBI:50325 proteinogenic amino-acid side-chain group CHEBI:50325 canonical amino-acid side-chain ChEBI canonical amino-acid side-chains ChEBI proteinogenic amino-acid side-chain ChEBI proteinogenic amino-acid side-chain groups ChEBI proteinogenic amino-acid side-chains ChEBI chebi_ontology -CH2-SH HS-CH2- cysteine side-chain CHEBI:50326 sulfanylmethyl group CHEBI:50326 -CH2-SH IUPAC HS-CH2- IUPAC cysteine side-chain ChEBI chebi_ontology glutamic acid side-chain CHEBI:50329 2-carboxyethyl group CHEBI:50329 glutamic acid side-chain ChEBI An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3). Wikipedia:Dihydrofolate_reductase_inhibitor chebi_ontology 7,8-dihydrofolate reductase inhibitor 7,8-dihydrofolate reductase inhibitors DHFR inhibitor DHFR inhibitors EC 1.5.1.3 (dihydrofolate reductase) inhibitors EC 1.5.1.3 inhibitor EC 1.5.1.3 inhibitors NADPH-dihydrofolate reductase inhibitor NADPH-dihydrofolate reductase inhibitors dihydrofolate reductase (EC 1.5.1.3) inhibitor dihydrofolate reductase (EC 1.5.1.3) inhibitors dihydrofolate reductase inhibitor dihydrofolate reductase inhibitors dihydrofolic acid reductase inhibitor dihydrofolic acid reductase inhibitors dihydrofolic reductase inhibitor dihydrofolic reductase inhibitors folic acid reductase inhibitor folic acid reductase inhibitors folic reductase inhibitor folic reductase inhibitors tetrahydrofolate dehydrogenase inhibitor tetrahydrofolate dehydrogenase inhibitors CHEBI:50683 EC 1.5.1.3 (dihydrofolate reductase) inhibitor CHEBI:50683 7,8-dihydrofolate reductase inhibitor ChEBI 7,8-dihydrofolate reductase inhibitors ChEBI DHFR inhibitor ChEBI DHFR inhibitors ChEBI EC 1.5.1.3 (dihydrofolate reductase) inhibitors ChEBI EC 1.5.1.3 inhibitor ChEBI EC 1.5.1.3 inhibitors ChEBI NADPH-dihydrofolate reductase inhibitor ChEBI NADPH-dihydrofolate reductase inhibitors ChEBI dihydrofolate reductase (EC 1.5.1.3) inhibitor ChEBI dihydrofolate reductase (EC 1.5.1.3) inhibitors ChEBI dihydrofolate reductase inhibitor ChEBI dihydrofolate reductase inhibitors ChEBI dihydrofolic acid reductase inhibitor ChEBI dihydrofolic acid reductase inhibitors ChEBI dihydrofolic reductase inhibitor ChEBI dihydrofolic reductase inhibitors ChEBI folic acid reductase inhibitor ChEBI folic acid reductase inhibitors ChEBI folic reductase inhibitor ChEBI folic reductase inhibitors ChEBI tetrahydrofolate dehydrogenase inhibitor ChEBI tetrahydrofolate dehydrogenase inhibitors ChEBI A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified. chebi_ontology cross-linking reagents CHEBI:50684 cross-linking reagent CHEBI:50684 cross-linking reagents ChEBI A compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues. CHEBI:25679 CHEBI:35319 CHEBI:7758 KEGG:C00930 Oligosaccharide chebi_ontology O-glycosylglycoside O-glycosylglycosides oligosacarido oligosacaridos CHEBI:50699 oligosaccharide CHEBI:50699 Oligosaccharide KEGG_COMPOUND O-glycosylglycoside ChEBI O-glycosylglycosides ChEBI oligosacarido ChEBI oligosacaridos IUPAC A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance. chebi_ontology Dietary Supplement Food Supplementation Nutritional supplement CHEBI:50733 nutraceutical CHEBI:50733 Dietary Supplement ChEBI Food Supplementation ChEBI Nutritional supplement ChEBI A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. CHEBI:132229 CHEBI:50234 chebi_ontology DNA gyrase inhibitor DNA gyrase inhibitors DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors DNA topoisomerase (ATP-hydrolysing) inhibitor DNA topoisomerase (ATP-hydrolysing) inhibitors DNA topoisomerase II inhibitor DNA topoisomerase II inhibitors EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors EC 5.99.1.3 inhibitor EC 5.99.1.3 inhibitors inhibitor of type II topoisomerase inhibitors of type II topoisomerase topoisomerase II inhibitor topoisomerase II inhibitors topoisomerase-II inhibitor topoisomerase-II inhibitors type II DNA topoisomerase inhibitor type II DNA topoisomerase inhibitors CHEBI:50750 EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor CHEBI:50750 DNA gyrase inhibitor ChEBI DNA gyrase inhibitors ChEBI DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor ChEBI DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors ChEBI DNA topoisomerase (ATP-hydrolysing) inhibitor ChEBI DNA topoisomerase (ATP-hydrolysing) inhibitors ChEBI DNA topoisomerase II inhibitor ChEBI DNA topoisomerase II inhibitors ChEBI EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor ChEBI EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors ChEBI EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors ChEBI EC 5.99.1.3 inhibitor ChEBI EC 5.99.1.3 inhibitors ChEBI inhibitor of type II topoisomerase ChEBI inhibitors of type II topoisomerase ChEBI topoisomerase II inhibitor ChEBI topoisomerase II inhibitors ChEBI topoisomerase-II inhibitor ChEBI topoisomerase-II inhibitors ChEBI type II DNA topoisomerase inhibitor ChEBI type II DNA topoisomerase inhibitors ChEBI Biologically active substance whose activity affects or plays a role in the functioning of the immune system. Wikipedia:Immunotherapy chebi_ontology Biomodulator Immune factor Immunologic factor Immunological factor immunomodulators CHEBI:50846 immunomodulator CHEBI:50846 Biomodulator ChEBI Immune factor ChEBI Immunologic factor ChEBI Immunological factor ChEBI immunomodulators ChEBI Any molecular entity that contains carbon. CHEBI:25700 CHEBI:33244 chebi_ontology organic compounds organic entity organic molecular entities CHEBI:50860 organic molecular entity CHEBI:50860 organic compounds ChEBI organic entity ChEBI organic molecular entities ChEBI chebi_ontology azaarenes CHEBI:50893 azaarene CHEBI:50893 azaarenes ChEBI A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells. Wikipedia:Genotoxicity chebi_ontology genotoxic agent genotoxic agents genotoxins CHEBI:50902 genotoxin CHEBI:50902 genotoxic agent ChEBI genotoxic agents ChEBI genotoxins ChEBI A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities. chebi_ontology agente carcinogeno cancerigene cancerogene carcinogen carcinogene carcinogenic agents carcinogeno carcinogens CHEBI:50903 carcinogenic agent CHEBI:50903 agente carcinogeno ChEBI cancerigene ChEBI cancerogene ChEBI carcinogen ChEBI carcinogene ChEBI carcinogenic agents ChEBI carcinogeno ChEBI carcinogens ChEBI A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy. Wikipedia:Allergen chebi_ontology alergeno allergene allergenic agent CHEBI:50904 allergen CHEBI:50904 alergeno ChEBI allergene ChEBI allergenic agent ChEBI A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect. chebi_ontology agent teratogene teratogen teratogeno CHEBI:50905 teratogenic agent CHEBI:50905 agent teratogene ChEBI teratogen ChEBI teratogeno ChEBI A role is particular behaviour which a material entity may exhibit. chebi_ontology CHEBI:50906 role CHEBI:50906 A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals. chebi_ontology agente hepatotoxico hepatotoxic agents hepatotoxicant hepatotoxicants hepatotoxin hepatotoxins hepatoxic agent hepatoxicant CHEBI:50908 hepatotoxic agent CHEBI:50908 agente hepatotoxico ChEBI hepatotoxic agents ChEBI hepatotoxicant ChEBI hepatotoxicants ChEBI hepatotoxin ChEBI hepatotoxins ChEBI hepatoxic agent ChEBI hepatoxicant ChEBI A role played by any chemical compound (natural or synthetic) exhibiting itself through the ability to induce damage to the kidneys. chebi_ontology agente nefrotoxico nephrotoxic agents nephrotoxicant CHEBI:50909 nephrotoxic agent CHEBI:50909 agente nefrotoxico ChEBI nephrotoxic agents ChEBI nephrotoxicant ChEBI A poison that interferes with the functions of the nervous system. CHEBI:50911 Wikipedia:Neurotoxin chebi_ontology agente neurotoxico nerve poison nerve poisons neurotoxic agent neurotoxic agents neurotoxicant neurotoxins CHEBI:50910 neurotoxin CHEBI:50910 agente neurotoxico ChEBI nerve poison ChEBI nerve poisons ChEBI neurotoxic agent ChEBI neurotoxic agents ChEBI neurotoxicant ChEBI neurotoxins ChEBI An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine. CHEBI:75764 chebi_ontology A-kinase inhibitor A-kinase inhibitors AP50 kinase inhibitor AP50 kinase inhibitors ATP-protein transphosphorylase inhibitor ATP-protein transphosphorylase inhibitors ATP:protein phosphotransferase (non-specific) inhibitor ATP:protein phosphotransferase (non-specific) inhibitors BR serine/threonine-protein kinase 2 inhibitor BR serine/threonine-protein kinase 2 inhibitors CK-2 inhibitor CK-2 inhibitors CKI inhibitor CKI inhibitors CKII inhibitor CKII inhibitors EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitors EC 2.7.11.1 inhibitor EC 2.7.11.1 inhibitors HIPK2 inhibitor HIPK2 inhibitors Hpr kinase inhibitor Hpr kinase inhibitors M phase-specific cdc2 kinase inhibitor M phase-specific cdc2 kinase inhibitors MKNK2 inhibitor MKNK2 inhibitors PAK-1 inhibitor PAK-1 inhibitors PAK1 inhibitor PAK1 inhibitors PKA inhibitor PKA inhibitors Prp4 protein kinase inhibitor Prp4 protein kinase inhibitors Raf kinase inhibitor Raf kinase inhibitors Raf-1 inhibitor Raf-1 inhibitors STK32 inhibitor STK32 inhibitors T-antigen kinase inhibitor T-antigen kinase inhibitors WEE1Hu inhibitor WEE1Hu inhibitors Wee 1-like kinase inhibitor Wee 1-like kinase inhibitors Wee-kinase inhibitor Wee-kinase inhibitors betaIIPKC inhibitor betaIIPKC inhibitors cAMP-dependent protein kinase A inhibitor cAMP-dependent protein kinase A inhibitors cAMP-dependent protein kinase inhibitor cAMP-dependent protein kinase inhibitors cGMP-dependent protein kinase inhibitor cGMP-dependent protein kinase inhibitors calcium-dependent protein kinase C inhibitor calcium-dependent protein kinase C inhibitors calcium/phospholipid-dependent protein kinase inhibitor calcium/phospholipid-dependent protein kinase inhibitors casein kinase (phosphorylating) inhibitor casein kinase (phosphorylating) inhibitors casein kinase 2 inhibitor casein kinase 2 inhibitors casein kinase I inhibitor casein kinase I inhibitors casein kinase II inhibitor casein kinase II inhibitors casein kinase inhibitor casein kinase inhibitors cyclic AMP-dependent protein kinase A inhibitor cyclic AMP-dependent protein kinase A inhibitors cyclic AMP-dependent protein kinase inhibitor cyclic AMP-dependent protein kinase inhibitors cyclic monophosphate-dependent protein kinase inhibitor cyclic monophosphate-dependent protein kinase inhibitors cyclic nucleotide-dependent protein kinase inhibitor cyclic nucleotide-dependent protein kinase inhibitors cyclin-dependent kinase inhibitor cyclin-dependent kinase inhibitors dsk1 inhibitor dsk1 inhibitors epsilon PKC inhibitor epsilon PKC inhibitors glycogen synthase a kinase inhibitor glycogen synthase a kinase inhibitors glycogen synthase kinase inhibitor glycogen synthase kinase inhibitors hydroxyalkyl-protein kinase inhibitor hydroxyalkyl-protein kinase inhibitors mitogen-activated S6 kinase inhibitor mitogen-activated S6 kinase inhibitors non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitor non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors non-specific serine/threonine protein kinase inhibitor non-specific serine/threonine protein kinase inhibitors p21 activated kinase-1 inhibitor p21 activated kinase-1 inhibitors p82 kinase inhibitor p82 kinase inhibitors phosphorylase b kinase kinase inhibitor phosphorylase b kinase kinase inhibitors protein glutamyl kinase inhibitor protein glutamyl kinase inhibitors protein kinase (phosphorylating) inhibitor protein kinase (phosphorylating) inhibitors protein kinase A inhibitor protein kinase A inhibitors protein kinase CK2 inhibitor protein kinase CK2 inhibitors protein kinase p58 inhibitor protein kinase p58 inhibitors protein phosphokinase inhibitor protein phosphokinase inhibitors protein serine kinase inhibitor protein serine kinase inhibitors protein serine-threonine kinase inhibitor protein serine-threonine kinase inhibitors protein-aspartyl kinase inhibitor protein-aspartyl kinase inhibitors protein-cysteine kinase inhibitor protein-cysteine kinase inhibitors protein-serine kinase inhibitor protein-serine kinase inhibitors protein-serine/threonine kinase inhibitors ribosomal S6 protein kinase inhibitor ribosomal S6 protein kinase inhibitors ribosomal protein S6 kinase II inhibitor ribosomal protein S6 kinase II inhibitors serine kinase inhibitor serine kinase inhibitors serine protein kinase inhibitor serine protein kinase inhibitors serine(threonine) protein kinase inhibitor serine(threonine) protein kinase inhibitors serine-specific protein kinase inhibitor serine-specific protein kinase inhibitors serine/threonine protein kinase inhibitor serine/threonine protein kinase inhibitors threonine-specific protein kinase inhibitor threonine-specific protein kinase inhibitors twitchin kinase inhibitor twitchin kinase inhibitors type-2 casein kinase inhibitor type-2 casein kinase inhibitors CHEBI:50925 EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor CHEBI:50925 A-kinase inhibitor ChEBI A-kinase inhibitors ChEBI AP50 kinase inhibitor ChEBI AP50 kinase inhibitors ChEBI ATP-protein transphosphorylase inhibitor ChEBI ATP-protein transphosphorylase inhibitors ChEBI ATP:protein phosphotransferase (non-specific) inhibitor ChEBI ATP:protein phosphotransferase (non-specific) inhibitors ChEBI BR serine/threonine-protein kinase 2 inhibitor ChEBI BR serine/threonine-protein kinase 2 inhibitors ChEBI CK-2 inhibitor ChEBI CK-2 inhibitors ChEBI CKI inhibitor ChEBI CKI inhibitors ChEBI CKII inhibitor ChEBI CKII inhibitors ChEBI EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitors ChEBI EC 2.7.11.1 inhibitor ChEBI EC 2.7.11.1 inhibitors ChEBI HIPK2 inhibitor ChEBI HIPK2 inhibitors ChEBI Hpr kinase inhibitor ChEBI Hpr kinase inhibitors ChEBI M phase-specific cdc2 kinase inhibitor ChEBI M phase-specific cdc2 kinase inhibitors ChEBI MKNK2 inhibitor ChEBI MKNK2 inhibitors ChEBI PAK-1 inhibitor ChEBI PAK-1 inhibitors ChEBI PAK1 inhibitor ChEBI PAK1 inhibitors ChEBI PKA inhibitor ChEBI PKA inhibitors ChEBI Prp4 protein kinase inhibitor ChEBI Prp4 protein kinase inhibitors ChEBI Raf kinase inhibitor ChEBI Raf kinase inhibitors ChEBI Raf-1 inhibitor ChEBI Raf-1 inhibitors ChEBI STK32 inhibitor ChEBI STK32 inhibitors ChEBI T-antigen kinase inhibitor ChEBI T-antigen kinase inhibitors ChEBI WEE1Hu inhibitor ChEBI WEE1Hu inhibitors ChEBI Wee 1-like kinase inhibitor ChEBI Wee 1-like kinase inhibitors ChEBI Wee-kinase inhibitor ChEBI Wee-kinase inhibitors ChEBI betaIIPKC inhibitor ChEBI betaIIPKC inhibitors ChEBI cAMP-dependent protein kinase A inhibitor ChEBI cAMP-dependent protein kinase A inhibitors ChEBI cAMP-dependent protein kinase inhibitor ChEBI cAMP-dependent protein kinase inhibitors ChEBI cGMP-dependent protein kinase inhibitor ChEBI cGMP-dependent protein kinase inhibitors ChEBI calcium-dependent protein kinase C inhibitor ChEBI calcium-dependent protein kinase C inhibitors ChEBI calcium/phospholipid-dependent protein kinase inhibitor ChEBI calcium/phospholipid-dependent protein kinase inhibitors ChEBI casein kinase (phosphorylating) inhibitor ChEBI casein kinase (phosphorylating) inhibitors ChEBI casein kinase 2 inhibitor ChEBI casein kinase 2 inhibitors ChEBI casein kinase I inhibitor ChEBI casein kinase I inhibitors ChEBI casein kinase II inhibitor ChEBI casein kinase II inhibitors ChEBI casein kinase inhibitor ChEBI casein kinase inhibitors ChEBI cyclic AMP-dependent protein kinase A inhibitor ChEBI cyclic AMP-dependent protein kinase A inhibitors ChEBI cyclic AMP-dependent protein kinase inhibitor ChEBI cyclic AMP-dependent protein kinase inhibitors ChEBI cyclic monophosphate-dependent protein kinase inhibitor ChEBI cyclic monophosphate-dependent protein kinase inhibitors ChEBI cyclic nucleotide-dependent protein kinase inhibitor ChEBI cyclic nucleotide-dependent protein kinase inhibitors ChEBI cyclin-dependent kinase inhibitor ChEBI cyclin-dependent kinase inhibitors ChEBI dsk1 inhibitor ChEBI dsk1 inhibitors ChEBI epsilon PKC inhibitor ChEBI epsilon PKC inhibitors ChEBI glycogen synthase a kinase inhibitor ChEBI glycogen synthase a kinase inhibitors ChEBI glycogen synthase kinase inhibitor ChEBI glycogen synthase kinase inhibitors ChEBI hydroxyalkyl-protein kinase inhibitor ChEBI hydroxyalkyl-protein kinase inhibitors ChEBI mitogen-activated S6 kinase inhibitor ChEBI mitogen-activated S6 kinase inhibitors ChEBI non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitor ChEBI non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors ChEBI non-specific serine/threonine protein kinase inhibitor ChEBI non-specific serine/threonine protein kinase inhibitors ChEBI p21 activated kinase-1 inhibitor ChEBI p21 activated kinase-1 inhibitors ChEBI p82 kinase inhibitor ChEBI p82 kinase inhibitors ChEBI phosphorylase b kinase kinase inhibitor ChEBI phosphorylase b kinase kinase inhibitors ChEBI protein glutamyl kinase inhibitor ChEBI protein glutamyl kinase inhibitors ChEBI protein kinase (phosphorylating) inhibitor ChEBI protein kinase (phosphorylating) inhibitors ChEBI protein kinase A inhibitor ChEBI protein kinase A inhibitors ChEBI protein kinase CK2 inhibitor ChEBI protein kinase CK2 inhibitors ChEBI protein kinase p58 inhibitor ChEBI protein kinase p58 inhibitors ChEBI protein phosphokinase inhibitor ChEBI protein phosphokinase inhibitors ChEBI protein serine kinase inhibitor ChEBI protein serine kinase inhibitors ChEBI protein serine-threonine kinase inhibitor ChEBI protein serine-threonine kinase inhibitors ChEBI protein-aspartyl kinase inhibitor ChEBI protein-aspartyl kinase inhibitors ChEBI protein-cysteine kinase inhibitor ChEBI protein-cysteine kinase inhibitors ChEBI protein-serine kinase inhibitor ChEBI protein-serine kinase inhibitors ChEBI protein-serine/threonine kinase inhibitors ChEBI ribosomal S6 protein kinase inhibitor ChEBI ribosomal S6 protein kinase inhibitors ChEBI ribosomal protein S6 kinase II inhibitor ChEBI ribosomal protein S6 kinase II inhibitors ChEBI serine kinase inhibitor ChEBI serine kinase inhibitors ChEBI serine protein kinase inhibitor ChEBI serine protein kinase inhibitors ChEBI serine(threonine) protein kinase inhibitor ChEBI serine(threonine) protein kinase inhibitors ChEBI serine-specific protein kinase inhibitor ChEBI serine-specific protein kinase inhibitors ChEBI serine/threonine protein kinase inhibitor ChEBI serine/threonine protein kinase inhibitors ChEBI threonine-specific protein kinase inhibitor ChEBI threonine-specific protein kinase inhibitors ChEBI twitchin kinase inhibitor ChEBI twitchin kinase inhibitors ChEBI type-2 casein kinase inhibitor ChEBI type-2 casein kinase inhibitors ChEBI chebi_ontology aziridinium ion CHEBI:50929 aziridinium CHEBI:50929 aziridinium ion ChEBI Thioxanthene and its substitution derivatives. chebi_ontology CHEBI:50930 thioxanthenes CHEBI:50930 Compounds containing an aziridine ring that contains a quaternary nitrogen atom. chebi_ontology aziridinium ions CHEBI:50946 aziridinium ion CHEBI:50946 aziridinium ions ChEBI A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups. chebi_ontology tertiary amino compounds CHEBI:50996 tertiary amino compound CHEBI:50996 tertiary amino compounds ChEBI A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. CHEBI:19039 CHEBI:6552 DrugBank:DB04967 HMDB:HMDB0015607 KEGG:C11715 Wikipedia:Lucanthone Lucanthone chebi_ontology 1-((2-(diethylamino)ethyl)amino)-4-methylthioxanthen-9-one 1-diethylaminoethylethylamino-4-methyl-thioxanthenone 1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one CHEBI:51052 lucanthone CHEBI:51052 Lucanthone KEGG_COMPOUND 1-((2-(diethylamino)ethyl)amino)-4-methylthioxanthen-9-one ChemIDplus 1-diethylaminoethylethylamino-4-methyl-thioxanthenone ChEBI 1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one ChEBI A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. chebi_ontology hormone receptor modulators CHEBI:51061 hormone receptor modulator CHEBI:51061 hormone receptor modulators ChEBI chebi_ontology CHEBI:51067 tetraphenes CHEBI:51067 chebi_ontology organic halide salts CHEBI:51069 organic halide salt CHEBI:51069 organic halide salts ChEBI chebi_ontology CHEBI:51070 Janus Green B cation CHEBI:51070 A role played by the molecular entity or part thereof within a chemical context. chebi_ontology CHEBI:51086 chemical role CHEBI:51086 CHEBI:25556 CHEBI:7594 KEGG:C06061 chebi_ontology Nitrogenous compounds nitrogen compounds nitrogen molecular entities CHEBI:51143 nitrogen molecular entity CHEBI:51143 Nitrogenous compounds KEGG_COMPOUND nitrogen compounds ChEBI nitrogen molecular entities ChEBI nitrogen group chebi_ontology nitrogen groups nitrogen-containing group nitrogenous group CHEBI:51144 nitrogen group CHEBI:51144 nitrogen group ChEBI nitrogen groups ChEBI nitrogen-containing group ChEBI nitrogenous group ChEBI An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case. chebi_ontology dipolar compounds CHEBI:51151 dipolar compound CHEBI:51151 dipolar compounds ChEBI chebi_ontology diammine(dichloro)platinum diammineplatinum dichloride CHEBI:51214 diamminedichloroplatinum CHEBI:51214 diammine(dichloro)platinum ChEBI diammineplatinum dichloride NIST_Chemistry_WebBook Sulfate salts where the cation is a metal ion. chebi_ontology metal sulfates CHEBI:51336 metal sulfate CHEBI:51336 metal sulfates ChEBI An angular ortho-fused polycyclic arene consisting of four fused benzene rings. CHEBI:33088 CHEBI:34557 KEGG:C14317 Patent:DE481819 Patent:DE486766 Wikipedia:Tetraphene chebi_ontology 1,2-Benzanthracene 1,2-Benzanthrazen 2,3-benzphenanthrene Benz[a]anthracene benzanthrene naphthanthracene CHEBI:51348 tetraphene CHEBI:51348 1,2-Benzanthracene KEGG_COMPOUND 1,2-Benzanthrazen ChemIDplus 2,3-benzphenanthrene ChemIDplus Benz[a]anthracene KEGG_COMPOUND benzanthrene NIST_Chemistry_WebBook naphthanthracene ChemIDplus Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s). chebi_ontology organodiyl groups CHEBI:51422 organodiyl group CHEBI:51422 organodiyl groups ChEBI chebi_ontology CHEBI:51446 organic divalent group CHEBI:51446 chebi_ontology CHEBI:51447 organic univalent group CHEBI:51447 A carboxamide resulting from the formal condensation of a carboxylic acid with the amino group of an amino acid. CHEBI:21653 CHEBI:22226 chebi_ontology N-acyl amino acid N-acyl amino acids N-acyl-amino-acid N-acyl-amino-acids N-acylamino acid N-acylamino acids acyl-amino-acid acyl-amino-acids acylamino acids CHEBI:51569 N-acyl-amino acid CHEBI:51569 N-acyl amino acid ChEBI N-acyl amino acids ChEBI N-acyl-amino-acid ChEBI N-acyl-amino-acids ChEBI N-acylamino acid ChEBI N-acylamino acids ChEBI acyl-amino-acid ChEBI acyl-amino-acids ChEBI acylamino acids ChEBI Acridines which are substituted in any position by one or more amino groups or substituted amino groups. Note that the term 'aminoacridine' is the International Prorietary Name (INN) for 9-aminoacridine. chebi_ontology aminoacridine CHEBI:51803 aminoacridines CHEBI:51803 aminoacridine ChEBI chebi_ontology organic polycyclic compounds CHEBI:51958 organic polycyclic compound CHEBI:51958 organic polycyclic compounds ChEBI chebi_ontology organic tricyclic compounds CHEBI:51959 organic tricyclic compound CHEBI:51959 organic tricyclic compounds ChEBI A biological role played by the molecular entity or part thereof within a biochemical context. chebi_ontology CHEBI:52206 biochemical role CHEBI:52206 chebi_ontology CHEBI:52208 biophysical role CHEBI:52208 A role played by the molecular entity or part thereof which causes the development of a pathological process. chebi_ontology etiopathogenetic agent etiopathogenetic role CHEBI:52209 aetiopathogenetic role CHEBI:52209 etiopathogenetic agent ChEBI etiopathogenetic role ChEBI A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties. chebi_ontology CHEBI:52210 pharmacological role CHEBI:52210 chebi_ontology CHEBI:52211 physiological role CHEBI:52211 Any substance introduced into a living organism with therapeutic or diagnostic purpose. CHEBI:33293 CHEBI:33294 chebi_ontology farmaco medicament pharmaceuticals CHEBI:52217 pharmaceutical CHEBI:52217 farmaco ChEBI medicament ChEBI pharmaceuticals ChEBI A member of the class of butanediols that is butane in which two of the hydrogens have been replaced by hydroxy groups. chebi_ontology butanediols CHEBI:52684 butanediol CHEBI:52684 butanediols ChEBI A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel. KEGG:D00541 LINCS:LSM-5614 Patent:NL6410359 Patent:US3294803 Patent:US3312598 Wikipedia:Hycanthone Hycanthone chebi_ontology 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one 1-(2-diethylaminoethylamino)-4-(hydroxymethyl)thioxanthen-9-one Hycanthon Lucanthone metabolite CHEBI:52768 hycanthone CHEBI:52768 Hycanthone KEGG_DRUG 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one ChemIDplus 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one ChemIDplus 1-(2-diethylaminoethylamino)-4-(hydroxymethyl)thioxanthen-9-one ChEBI Hycanthon ChemIDplus Lucanthone metabolite ChemIDplus An antagonist at the A2A receptor. Wikipedia:Adenosine_A2A_receptor chebi_ontology adenosine A2A receptor antagonists CHEBI:53121 adenosine A2A receptor antagonist CHEBI:53121 adenosine A2A receptor antagonists ChEBI Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis. chebi_ontology (3)HTdR (3H)Thymidine Thymidine-(H-3) tritiated thymidines CHEBI:53526 tritiated thymidine CHEBI:53526 (3)HTdR ChEBI (3H)Thymidine ChemIDplus Thymidine-(H-3) ChemIDplus tritiated thymidines ChEBI A cyclic compound having as ring members atoms of at least two different elements. Heterocyclic compound chebi_ontology compuesto heterociclico compuestos heterociclicos heterocycle heterocyclic compounds CHEBI:5686 heterocyclic compound CHEBI:5686 Heterocyclic compound KEGG_COMPOUND compuesto heterociclico IUPAC compuestos heterociclicos IUPAC heterocycle ChEBI heterocyclic compounds ChEBI A D-alpha-amino acid zwitterion that is D-phenylalanine in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3. MetaCyc:CPD-216 chebi_ontology (2R)-2-ammonio-3-phenylpropanoate D-phenylalanine CHEBI:57981 D-phenylalanine zwitterion CHEBI:57981 (2R)-2-ammonio-3-phenylpropanoate IUPAC D-phenylalanine UniProt An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of L-phenylalanine; major species at pH 7.3. MetaCyc:PHE chebi_ontology (2S)-2-ammonio-3-phenylpropanoate L-phenylalanine phenylalanine CHEBI:58095 L-phenylalanine zwitterion CHEBI:58095 (2S)-2-ammonio-3-phenylpropanoate IUPAC L-phenylalanine UniProt phenylalanine ChEBI An amino-acid residue protonated on nitrogen. chebi_ontology amino acid cation residue amino acid cation residues amino-acid cation residue amino-acid cation residues cationic amino acid residue cationic amino acid residues cationic amino-acid residues CHEBI:58942 cationic amino-acid residue CHEBI:58942 amino acid cation residue ChEBI amino acid cation residues ChEBI amino-acid cation residue ChEBI amino-acid cation residues ChEBI cationic amino acid residue ChEBI cationic amino acid residues ChEBI cationic amino-acid residues ChEBI Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6). chebi_ontology a short-chain fatty acid short-chain fatty acid anions CHEBI:58951 short-chain fatty acid anion CHEBI:58951 a short-chain fatty acid UniProt short-chain fatty acid anions ChEBI Any fatty acid anion in which there is no C-C unsaturation. chebi_ontology saturated fatty acid anions CHEBI:58953 saturated fatty acid anion CHEBI:58953 saturated fatty acid anions ChEBI Any saturated fatty acid anion lacking a carbon side-chain. chebi_ontology straight-chain saturated fatty acid anions CHEBI:58954 straight-chain saturated fatty acid anion CHEBI:58954 straight-chain saturated fatty acid anions ChEBI An organic anion of general formula RS(=O)2O(-) where R is an organyl group. chebi_ontology organosulfate oxoanions CHEBI:58958 organosulfate oxoanion CHEBI:58958 organosulfate oxoanions ChEBI Any fatty acid whose skeletal carbon atoms form an unbranched open chain. chebi_ontology straight-chain fatty acids CHEBI:59202 straight-chain fatty acid CHEBI:59202 straight-chain fatty acids ChEBI A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid. chebi_ontology straight-chain FA anion straight-chain FA anions straight-chain fatty acid anions CHEBI:59203 straight-chain fatty acid anion CHEBI:59203 straight-chain FA anion ChEBI straight-chain FA anions ChEBI straight-chain fatty acid anions ChEBI Compounds containing one or more phosphoric acid units. chebi_ontology CHEBI:59698 phosphoric acids CHEBI:59698 A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons. chebi_ontology nucleophile nucleophiles nucleophilic reagents CHEBI:59740 nucleophilic reagent CHEBI:59740 nucleophile ChEBI nucleophiles ChEBI nucleophilic reagents ChEBI Hydroxy boron compounds of general formula BxOyHz. chebi_ontology CHEBI:59765 boric acids CHEBI:59765 Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group. chebi_ontology L-alpha-amino carboxylate CHEBI:59814 L-alpha-amino acid anion CHEBI:59814 L-alpha-amino carboxylate ChEBI Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group. chebi_ontology L-alpha-amino acid zwitterions an L-alpha-amino acid CHEBI:59869 L-alpha-amino acid zwitterion CHEBI:59869 L-alpha-amino acid zwitterions ChEBI an L-alpha-amino acid UniProt Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group. chebi_ontology D-alpha-amino acid zwitterions a D-alpha-amino acid CHEBI:59871 D-alpha-amino acid zwitterion CHEBI:59871 D-alpha-amino acid zwitterions ChEBI a D-alpha-amino acid UniProt A carboxylic acid anion that is the conjugate base of an N-acyl-L-alpha-amino acid arising from deprotonation of the C-1 carboxy group. chebi_ontology N-acyl-L-alpha-amino acid(1-) an N-acyl-L-amino acid CHEBI:59874 N-acyl-L-alpha-amino acid anion CHEBI:59874 N-acyl-L-alpha-amino acid(1-) ChEBI an N-acyl-L-amino acid UniProt The conjugate base of an N-acyl-D-alpha-amino acid arising from deprotonation of the C-1 carboxy group. chebi_ontology N-acyl-D-alpha-amino acid(1-) an N-acyl-D-amino acid CHEBI:59876 N-acyl-D-alpha-amino acid anion CHEBI:59876 N-acyl-D-alpha-amino acid(1-) ChEBI an N-acyl-D-amino acid UniProt A DNA polymerase inhibitor that interferes with the activity of reverse transcriptase, EC 2.7.7.49, a viral DNA polymerase enzyme that retroviruses need in order to reproduce. Wikipedia:Reverse-transcriptase_inhibitor chebi_ontology DNA nucleotidyltransferase (RNA-directed) inhibitor DNA nucleotidyltransferase (RNA-directed) inhibitors EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitors EC 2.7.7.49 inhibitor EC 2.7.7.49 inhibitors RNA revertase inhibitor RNA revertase inhibitors RNA-dependent DNA polymerase inhibitor RNA-dependent DNA polymerase inhibitors RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitor RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitors RNA-directed DNA polymerase (EC 2.7.7.49) inhibitor RNA-directed DNA polymerase (EC 2.7.7.49) inhibitors RNA-directed DNA polymerase inhibitor RNA-directed DNA polymerase inhibitors RNA-instructed DNA polymerase inhibitor RNA-instructed DNA polymerase inhibitors RT inhibitor RT inhibitors deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitor deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitors reverse transcriptase inhibitor reverse transcriptase inhibitors revertase inhibitor revertase inhibitors telomerase inhibitor telomerase inhibitors CHEBI:59897 EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor CHEBI:59897 DNA nucleotidyltransferase (RNA-directed) inhibitor ChEBI DNA nucleotidyltransferase (RNA-directed) inhibitors ChEBI EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitors ChEBI EC 2.7.7.49 inhibitor ChEBI EC 2.7.7.49 inhibitors ChEBI RNA revertase inhibitor ChEBI RNA revertase inhibitors ChEBI RNA-dependent DNA polymerase inhibitor ChEBI RNA-dependent DNA polymerase inhibitors ChEBI RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitor ChEBI RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitors ChEBI RNA-directed DNA polymerase (EC 2.7.7.49) inhibitor ChEBI RNA-directed DNA polymerase (EC 2.7.7.49) inhibitors ChEBI RNA-directed DNA polymerase inhibitor ChEBI RNA-directed DNA polymerase inhibitors ChEBI RNA-instructed DNA polymerase inhibitor ChEBI RNA-instructed DNA polymerase inhibitors ChEBI RT inhibitor ChEBI RT inhibitors ChEBI deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitor ChEBI deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitors ChEBI reverse transcriptase inhibitor ChEBI reverse transcriptase inhibitors ChEBI revertase inhibitor ChEBI revertase inhibitors ChEBI telomerase inhibitor ChEBI telomerase inhibitors ChEBI Any anion arising from deprotonation of at least one OH group in a flavonoid compound. chebi_ontology flavonoid oxoanions CHEBI:60038 flavonoid oxoanion CHEBI:60038 flavonoid oxoanions ChEBI A metal cation with a valence of two. chebi_ontology a divalent metal cation CHEBI:60240 divalent metal cation CHEBI:60240 a divalent metal cation UniProt An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one. chebi_ontology a monovalent cation CHEBI:60242 monovalent inorganic cation CHEBI:60242 a monovalent cation UniProt R = C or H. The iminium ion resulting from the protonation of one of the imine nitrogens of guanidine or its derivatives. chebi_ontology diaminomethaniminium ion diaminomethaniminium ions guanidinium ions CHEBI:60251 guanidinium ion CHEBI:60251 diaminomethaniminium ion ChEBI diaminomethaniminium ions ChEBI guanidinium ions ChEBI Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged. chebi_ontology a peptide peptide zwitterions CHEBI:60466 peptide zwitterion CHEBI:60466 a peptide UniProt peptide zwitterions ChEBI Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself. chebi_ontology adjuvants CHEBI:60809 adjuvant CHEBI:60809 adjuvants ChEBI Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules. chebi_ontology tubulin modulators CHEBI:60832 tubulin modulator CHEBI:60832 tubulin modulators ChEBI Any alpha-amino acid anion in which the parent amino acid has D-configuration. chebi_ontology D-alpha-amino acid anions D-alpha-amino carboxylate CHEBI:60895 D-alpha-amino acid anion CHEBI:60895 D-alpha-amino acid anions ChEBI D-alpha-amino carboxylate ChEBI Any compound that has a nucleobase as a part. chebi_ontology nucleobase-containing compound nucleobase-containing compounds nucleobase-containing molecular entities CHEBI:61120 nucleobase-containing molecular entity CHEBI:61120 nucleobase-containing compound SUBMITTER nucleobase-containing compounds ChEBI nucleobase-containing molecular entities ChEBI A flavonoid oxoanion that is the conjugate base of hesperetin arising from selective deprtotonation of the 7-hydroxy group. chebi_ontology hesperetin anion CHEBI:61249 hesperetin(1-) CHEBI:61249 hesperetin anion ChEBI chebi_ontology CHEBI:616459 carbamimidoylazanium CHEBI:616459 Any substance that interacts with tubulin to inhibit polymerisation of microtubules. chebi_ontology microtubule destabilising agent microtubule destabilising agents microtubule destabilising role microtubule destabilizing role microtubule-destabilising agents microtubule-destabilizing agent microtubule-destabilizing agents CHEBI:61951 microtubule-destabilising agent CHEBI:61951 microtubule destabilising agent ChEBI microtubule destabilising agents ChEBI microtubule destabilising role ChEBI microtubule destabilizing role SUBMITTER microtubule-destabilising agents ChEBI microtubule-destabilizing agent ChEBI microtubule-destabilizing agents ChEBI Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group. chebi_ontology a polar amino acid CHEBI:62031 polar amino acid zwitterion CHEBI:62031 a polar amino acid UniProt An alkanesulfonate in which the carbon at position 1 is attached to at least two hydrogens. KEGG:C15521 MetaCyc:Alkanesulfonates chebi_ontology 1,1-di-unsubstituted alkanesulfonate 1,1-di-unsubstituted alkanesulfonates 1,1-diunsubstituted alkanesulfonates CHEBI:62081 1,1-diunsubstituted alkanesulfonate CHEBI:62081 1,1-di-unsubstituted alkanesulfonate ChEBI 1,1-di-unsubstituted alkanesulfonates ChEBI 1,1-diunsubstituted alkanesulfonates ChEBI The dicarboxylic acid dianion formed from folic acid by loss of a proton from each of the two carboxy groups in the glutamic acid moiety. chebi_ontology folate pteroyl-L-glutamate pteroyl-L-monoglutamate pteroylglutamate CHEBI:62501 folate(2-) CHEBI:62501 folate MetaCyc folate UniProt pteroyl-L-glutamate ChEBI pteroyl-L-monoglutamate ChEBI pteroylglutamate ChEBI Any additive that enhances the efficiency of fuel. chebi_ontology fuel additives fuel enhancer CHEBI:62803 fuel additive CHEBI:62803 fuel additives ChEBI fuel enhancer ChEBI A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity. chebi_ontology glycosyl compounds CHEBI:63161 glycosyl compound CHEBI:63161 glycosyl compounds ChEBI The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species. Wikipedia:Reducing_agent chebi_ontology reducer reducers reducing agents reductant reductants CHEBI:63247 reducing agent CHEBI:63247 reducer ChEBI reducers ChEBI reducing agents ChEBI reductant ChEBI reductants ChEBI Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds. chebi_ontology carbohydrate derivatives derivatised carbohydrate derivatised carbohydrates derivatized carbohydrate derivatized carbohydrates CHEBI:63299 carbohydrate derivative CHEBI:63299 carbohydrate derivatives ChEBI derivatised carbohydrate ChEBI derivatised carbohydrates ChEBI derivatized carbohydrate ChEBI derivatized carbohydrates ChEBI An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of alkaline phosphatase (EC 3.1.3.1). Wikipedia:Alkaline_phosphatase chebi_ontology EC 3.1.3.1 (alkaline phosphatase) inhibitors EC 3.1.3.1 inhibitor EC 3.1.3.1 inhibitors alkaline phenyl phosphatase inhibitor alkaline phenyl phosphatase inhibitors alkaline phosphatase (EC 3.1.3.1) inhibitor alkaline phosphatase (EC 3.1.3.1) inhibitors alkaline phosphatase inhibitor alkaline phosphatase inhibitors alkaline phosphohydrolase inhibitor alkaline phosphohydrolase inhibitors alkaline phosphomonoesterase inhibitor alkaline phosphomonoesterase inhibitors glycerophosphatase inhibitor glycerophosphatase inhibitors orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitor orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitors phosphate-monoester phosphohydrolase (alkaline optimum) inhibitor phosphate-monoester phosphohydrolase (alkaline optimum) inhibitors phosphomonoesterase inhibitor phosphomonoesterase inhibitors CHEBI:63332 EC 3.1.3.1 (alkaline phosphatase) inhibitor CHEBI:63332 EC 3.1.3.1 (alkaline phosphatase) inhibitors ChEBI EC 3.1.3.1 inhibitor ChEBI EC 3.1.3.1 inhibitors ChEBI alkaline phenyl phosphatase inhibitor ChEBI alkaline phenyl phosphatase inhibitors ChEBI alkaline phosphatase (EC 3.1.3.1) inhibitor ChEBI alkaline phosphatase (EC 3.1.3.1) inhibitors ChEBI alkaline phosphatase inhibitor ChEBI alkaline phosphatase inhibitors ChEBI alkaline phosphohydrolase inhibitor ChEBI alkaline phosphohydrolase inhibitors ChEBI alkaline phosphomonoesterase inhibitor ChEBI alkaline phosphomonoesterase inhibitors ChEBI glycerophosphatase inhibitor ChEBI glycerophosphatase inhibitors ChEBI orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitor ChEBI orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitors ChEBI phosphate-monoester phosphohydrolase (alkaline optimum) inhibitor ChEBI phosphate-monoester phosphohydrolase (alkaline optimum) inhibitors ChEBI phosphomonoesterase inhibitor ChEBI phosphomonoesterase inhibitors ChEBI A carbohydrate derivative that is formally obtained from a disaccharide. chebi_ontology disaccharide derivatives CHEBI:63353 disaccharide derivative CHEBI:63353 disaccharide derivatives ChEBI A sulfur-containing amino acid whose alpha-carboxylic acid group is ionized (not protonated). chebi_ontology sulfur-containing amino-acid anions CHEBI:63470 sulfur-containing amino-acid anion CHEBI:63470 sulfur-containing amino-acid anions ChEBI An aromatic amino acid whose alpha-carboxylic acid group is ionized (non-protonated). chebi_ontology aromatic amino-acid anions CHEBI:63473 aromatic amino-acid anion CHEBI:63473 aromatic amino-acid anions ChEBI A substance capable of undergoing rapid and highly exothermic decomposition. Wikipedia:Explosive_material chebi_ontology explosive compound explosive compounds explosive material explosives explosives chemical explosives chemicals CHEBI:63490 explosive CHEBI:63490 explosive compound ChEBI explosive compounds ChEBI explosive material ChEBI explosives ChEBI explosives chemical ChEBI explosives chemicals ChEBI A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase. DrugBank:DB01265 KEGG:D06675 Wikipedia:Telbivudine chebi_ontology 1-(2-deoxy-beta-L-ribofuranosyl)-5-methyluracil 2'-Deoxy-L-thymidine Beta-l-thymidine Epavudine L-DT L-deoxythymidine L-thymidine LDT beta-L-2'-deoxythymidine CHEBI:63624 telbivudine CHEBI:63624 1-(2-deoxy-beta-L-ribofuranosyl)-5-methyluracil ChEBI 2'-Deoxy-L-thymidine DrugBank Beta-l-thymidine DrugBank Epavudine DrugBank L-DT DrugBank L-deoxythymidine DrugBank L-thymidine DrugBank LDT DrugBank beta-L-2'-deoxythymidine ChEBI Any substance which is added to food to preserve or enhance its flavour and/or appearance. Wikipedia:Food_additive chebi_ontology food additives CHEBI:64047 food additive CHEBI:64047 food additives ChEBI Any organic salt prepared using an organosulfonic acid as the acid component. chebi_ontology organosulfonate salts organosulphonate salt organosulphonate salts CHEBI:64382 organosulfonate salt CHEBI:64382 organosulfonate salts ChEBI organosulphonate salt ChEBI organosulphonate salts ChEBI A food additive which is added to flour or dough to improve baking quality and/or colour. Wikipedia:Flour_treatment_agent flour treatment agent chebi_ontology dough improver dough improvers improving agent improving agents CHEBI:64577 flour treatment agent CHEBI:64577 flour treatment agent ChEBI dough improver ChEBI dough improvers ChEBI improving agent ChEBI improving agents ChEBI An inorganic cation with a valency of two. chebi_ontology CHEBI:64641 divalent inorganic cation CHEBI:64641 An organic molecular entity containing a single carbon atom (C1). chebi_ontology one-carbon compounds CHEBI:64708 one-carbon compound CHEBI:64708 one-carbon compounds ChEBI Any organic molecular entity that is acidic and contains carbon in covalent linkage. chebi_ontology organic acids CHEBI:64709 organic acid CHEBI:64709 organic acids ChEBI A group that carries an overall positive charge. chebi_ontology cationic groups CHEBI:64766 cationic group CHEBI:64766 cationic groups ChEBI A group that carries an overall negative charge. chebi_ontology anionic groups CHEBI:64767 anionic group CHEBI:64767 anionic groups ChEBI A cationic group that contains carbon. chebi_ontology organic cationic groups CHEBI:64769 organic cationic group CHEBI:64769 organic cationic groups ChEBI An anionic group that contains carbon. chebi_ontology organic anionic groups CHEBI:64775 organic anionic group CHEBI:64775 organic anionic groups ChEBI The role played by a substance in enhancing the appearance or odour of the human body; a name given to the substance itself or to a component of it. Wikipedia:Cosmetics chebi_ontology cosmetic component cosmetics CHEBI:64857 cosmetic CHEBI:64857 cosmetic component ChEBI cosmetics ChEBI An amino-acid residue carrying an overall negative charge. chebi_ontology amino acid anion residue amino acid anion residues amino-acid anion residue amino-acid anion residues anionic amino acid residue anionic amino acid residues CHEBI:64898 anionic amino-acid residue CHEBI:64898 amino acid anion residue ChEBI amino acid anion residues ChEBI amino-acid anion residue ChEBI amino-acid anion residues ChEBI anionic amino acid residue ChEBI anionic amino acid residues ChEBI Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism. Wikipedia:Poison chebi_ontology poisonous agent poisonous agents poisonous substance poisonous substances poisons toxic agent toxic agents toxic substance toxic substances CHEBI:64909 poison CHEBI:64909 poisonous agent ChEBI poisonous agents ChEBI poisonous substance ChEBI poisonous substances ChEBI poisons ChEBI toxic agent ChEBI toxic agents ChEBI toxic substance ChEBI toxic substances ChEBI Any compound that inhibits cell division (mitosis). Wikipedia:Mitotic_inhibitor chebi_ontology antimitotics mitosis inhibitor mitosis inhibitors mitotic inhibitor mitotic inhibitors CHEBI:64911 antimitotic CHEBI:64911 antimitotics ChEBI mitosis inhibitor ChEBI mitosis inhibitors ChEBI mitotic inhibitor ChEBI mitotic inhibitors ChEBI An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria. chebi_ontology antiplasmodial agent antiplasmodial agents antiplasmodial drugs antiplasmodium agent antiplasmodium agents antiplasmodium drug antiplasmodium drugs CHEBI:64915 antiplasmodial drug CHEBI:64915 antiplasmodial agent ChEBI antiplasmodial agents ChEBI antiplasmodial drugs ChEBI antiplasmodium agent ChEBI antiplasmodium agents ChEBI antiplasmodium drug ChEBI antiplasmodium drugs ChEBI Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes. chebi_ontology food preservatives CHEBI:65255 food preservative CHEBI:65255 food preservatives ChEBI An N-acyl-L-alpha-amino acid anion obtained by deprotonation of any folic acid. chebi_ontology folate folate anion folate anions CHEBI:67011 folates CHEBI:67011 folate ChEBI folate anion ChEBI folate anions ChEBI A chemosterilant intended to sterilize insects. chebi_ontology insect chemosterilant insect chemosterilants insect sterilants CHEBI:67105 insect sterilant CHEBI:67105 insect chemosterilant ChEBI insect chemosterilants ChEBI insect sterilants ChEBI A methanesulfonate ester that is hexane-2,5-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. chebi_ontology 1,4-bis(methylsulfonyloxy)-1,4-dimethylbutane 1,4-dimethanesulfonoxy-1,4-dimethylbutane 1,4-dimethylbusulfan 1,4-dimethylmyleran 2,5-dimethanesulfomyloxyhexane 2,5-hexanediol dimesylate 2,5-hexanediol dimethylsulfonate DMM dimethylbusulfan CHEBI:67107 dimethylmyleran CHEBI:67107 1,4-bis(methylsulfonyloxy)-1,4-dimethylbutane ChemIDplus 1,4-dimethanesulfonoxy-1,4-dimethylbutane ChemIDplus 1,4-dimethylbusulfan ChEBI 1,4-dimethylmyleran ChEBI 2,5-dimethanesulfomyloxyhexane ChemIDplus 2,5-hexanediol dimesylate ChEBI 2,5-hexanediol dimethylsulfonate ChemIDplus DMM ChemIDplus dimethylbusulfan ChemIDplus A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction. Wikipedia:Ryanodine_receptor chebi_ontology RyR activator RyR activators RyR agonist RyR agonists RyRs activator RyRs agonist ryanodine receptor activator ryanodine receptor activators CHEBI:67114 ryanodine receptor agonist CHEBI:67114 RyR activator ChEBI RyR activators ChEBI RyR agonist ChEBI RyR agonists ChEBI RyRs activator ChEBI RyRs agonist ChEBI ryanodine receptor activator ChEBI ryanodine receptor activators ChEBI An ammonium ion resulting from the protonation of the tertiary amino group of lycanthone. chebi_ontology CHEBI:67141 hycanthone(1+) CHEBI:67141 A molecule that can substitute for a normal nucleobase in nucleic acids. Wikipedia:Base_analog chebi_ontology base analog base analogs base analogue base analogues nucleobase analog nucleobase analogs nucleobase analogues CHEBI:67142 nucleobase analogue CHEBI:67142 base analog ChEBI base analogs ChEBI base analogue ChEBI base analogues ChEBI nucleobase analog ChEBI nucleobase analogs ChEBI nucleobase analogues ChEBI A deoxyribonucleoside containing a pyrimidine base. MetaCyc:Pyrimidine-Deoxyribonucleosides chebi_ontology pyrimidine deoxyribonucleosides CHEBI:68472 pyrimidine deoxyribonucleoside CHEBI:68472 pyrimidine deoxyribonucleosides ChEBI Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms. chebi_ontology Type I cell-death inhibitor Type I cell-death inhibitors Type I programmed cell-death inhibitor Type I programmed cell-death inhibitors apoptosis inhibitors CHEBI:68494 apoptosis inhibitor CHEBI:68494 Type I cell-death inhibitor ChEBI Type I cell-death inhibitors ChEBI Type I programmed cell-death inhibitor ChEBI Type I programmed cell-death inhibitors ChEBI apoptosis inhibitors ChEBI Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. chebi_ontology Type I cell-death inducer Type I cell-death inducers Type I programmed cell-death inducer Type I programmed cell-death inducers apoptosis inducers CHEBI:68495 apoptosis inducer CHEBI:68495 Type I cell-death inducer ChEBI Type I cell-death inducers ChEBI Type I programmed cell-death inducer ChEBI Type I programmed cell-death inducers ChEBI apoptosis inducers ChEBI An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA). Wikipedia:Topoisomerase chebi_ontology topoisomerase inhibitors CHEBI:70727 topoisomerase inhibitor CHEBI:70727 topoisomerase inhibitors ChEBI An antagonist at any adenosine receptor. Wikipedia:Adenosine_receptor chebi_ontology adenosine receptor antagonists CHEBI:71232 adenosine receptor antagonist CHEBI:71232 adenosine receptor antagonists ChEBI An enzyme inhibitor that inhibits the action of a transferase (EC 2.*) Wikipedia:Transferase chebi_ontology EC 2 inhibitor EC 2 inhibitors EC 2.* (transferase) inhibitors EC 2.* inhibitor EC 2.* inhibitors transferase inhibitor transferase inhibitors CHEBI:71300 EC 2.* (transferase) inhibitor CHEBI:71300 EC 2 inhibitor ChEBI EC 2 inhibitors ChEBI EC 2.* (transferase) inhibitors ChEBI EC 2.* inhibitor ChEBI EC 2.* inhibitors ChEBI transferase inhibitor ChEBI transferase inhibitors ChEBI Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them. Wikipedia:Flavonoids chebi_ontology flavonoid CHEBI:72544 flavonoids CHEBI:72544 flavonoid ChEBI Any molecule that consists of at least one carbon atom as part of the electrically neutral entity. chebi_ontology organic compound organic compounds organic molecules CHEBI:72695 organic molecule CHEBI:72695 organic compound ChEBI organic compounds ChEBI organic molecules ChEBI A member of the class of flavanones having one or more glycosyl residues attached at unspecified positions. chebi_ontology flavanone glycosides CHEBI:72730 flavanone glycoside CHEBI:72730 flavanone glycosides ChEBI An L-alpha-amino acid which is biosynthesised from erythrose 4-phosphate and phosphoenolpyruvate (i.e. phenylalanine, tyrosine, and tryptophan). A closed class. chebi_ontology erythrose 4-phosphate and phosphoenolpyruvate family amino acid erythrose 4-phosphate and phosphoenolpyruvate family amino acids erythrose 4-phosphate family amino acid erythrose 4-phosphate family amino acids erythrose 4-phosphate/phosphoenolpyruvate family amino acids phosphoenolpyruvate family amino acid phosphoenolpyruvate family amino acids CHEBI:73690 erythrose 4-phosphate/phosphoenolpyruvate family amino acid CHEBI:73690 erythrose 4-phosphate and phosphoenolpyruvate family amino acid ChEBI erythrose 4-phosphate and phosphoenolpyruvate family amino acids ChEBI erythrose 4-phosphate family amino acid ChEBI erythrose 4-phosphate family amino acids ChEBI erythrose 4-phosphate/phosphoenolpyruvate family amino acids ChEBI phosphoenolpyruvate family amino acid ChEBI phosphoenolpyruvate family amino acids ChEBI An antimetabolite that impairs the action of folic acids Wikipedia:Antifolate chebi_ontology antifolates folic acid antagonist folic acid antagonists CHEBI:73913 antifolate CHEBI:73913 antifolates ChEBI folic acid antagonist ChEBI folic acid antagonists ChEBI A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions. Wikipedia:Astringent chebi_ontology adstringent adstringents astringents CHEBI:74783 astringent CHEBI:74783 adstringent ChEBI adstringents ChEBI astringents ChEBI An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*). chebi_ontology EC 5.* (isomerase) inhibitors EC 5.* inhibitor EC 5.* inhibitors EC 5.*.*.* inhibitor EC 5.*.*.* inhibitors isomerase (EC 5.*) inhibitor isomerase (EC 5.*) inhibitors isomerase inhibitor isomerase inhibitors CHEBI:75596 EC 5.* (isomerase) inhibitor CHEBI:75596 EC 5.* (isomerase) inhibitors ChEBI EC 5.* inhibitor ChEBI EC 5.* inhibitors ChEBI EC 5.*.*.* inhibitor ChEBI EC 5.*.*.* inhibitors ChEBI isomerase (EC 5.*) inhibitor ChEBI isomerase (EC 5.*) inhibitors ChEBI isomerase inhibitor ChEBI isomerase inhibitors ChEBI A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*). chebi_ontology C--N bond-forming ligase inhibitor C--N bond-forming ligase inhibitors C-N bond-forming ligase (EC 6.3.*) inhibitor C-N bond-forming ligase (EC 6.3.*) inhibitors C-N bond-forming ligase inhibitor C-N bond-forming ligase inhibitors EC 6.3.* (C-N bond-forming ligase) inhibitorS EC 6.3.* inhibitor EC 6.3.* inhibitors EC 6.3.*.* inhibitor EC 6.3.*.* inhibitors CHEBI:75600 EC 6.3.* (C-N bond-forming ligase) inhibitor CHEBI:75600 C--N bond-forming ligase inhibitor ChEBI C--N bond-forming ligase inhibitors ChEBI C-N bond-forming ligase (EC 6.3.*) inhibitor ChEBI C-N bond-forming ligase (EC 6.3.*) inhibitors ChEBI C-N bond-forming ligase inhibitor ChEBI C-N bond-forming ligase inhibitors ChEBI EC 6.3.* (C-N bond-forming ligase) inhibitorS ChEBI EC 6.3.* inhibitor ChEBI EC 6.3.* inhibitors ChEBI EC 6.3.*.* inhibitor ChEBI EC 6.3.*.* inhibitors ChEBI Any enzyme inhibitor that interferes with the action of a ligase (EC 6.*.*.*). Ligases are enzymes that catalyse the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. Wikipedia:Ligase chebi_ontology EC 6.* (ligase) inhibitors EC 6.* inhibitor EC 6.* inhibitors EC 6.*.*.* inhibitor EC 6.*.*.* inhibitors ligase inhibitor ligase inhibitors CHEBI:75603 EC 6.* (ligase) inhibitor CHEBI:75603 EC 6.* (ligase) inhibitors ChEBI EC 6.* inhibitor ChEBI EC 6.* inhibitors ChEBI EC 6.*.*.* inhibitor ChEBI EC 6.*.*.* inhibitors ChEBI ligase inhibitor ChEBI ligase inhibitors ChEBI Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms. chebi_ontology eukaryotic metabolites CHEBI:75763 eukaryotic metabolite CHEBI:75763 eukaryotic metabolites ChEBI Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals. CHEBI:77721 CHEBI:77743 chebi_ontology animal metabolites CHEBI:75767 animal metabolite CHEBI:75767 animal metabolites ChEBI Any animal metabolite produced during a metabolic reaction in mammals. CHEBI:77464 CHEBI:77744 chebi_ontology mammalian metabolites CHEBI:75768 mammalian metabolite CHEBI:75768 mammalian metabolites ChEBI Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises of vitamin B1, B2, B3, B5, B6, B7, B9, and B12 (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such). MetaCyc:B-vitamins Wikipedia:B_vitamin chebi_ontology B vitamins B-group vitamin B-group vitamins vitamin B CHEBI:75769 B vitamin CHEBI:75769 B vitamins ChEBI B-group vitamin ChEBI B-group vitamins ChEBI vitamin B ChEBI Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). chebi_ontology Mus musculus metabolite Mus musculus metabolites mouse metabolites CHEBI:75771 mouse metabolite CHEBI:75771 Mus musculus metabolite ChEBI Mus musculus metabolites ChEBI mouse metabolites ChEBI Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae). CHEBI:76949 CHEBI:76951 chebi_ontology S. cerevisiae metabolite S. cerevisiae metabolites S. cerevisiae secondary metabolite S. cerevisiae secondary metabolites Saccharomyces cerevisiae metabolites Saccharomyces cerevisiae secondary metabolites baker's yeast metabolite baker's yeast metabolites baker's yeast secondary metabolite baker's yeast secondary metabolites CHEBI:75772 Saccharomyces cerevisiae metabolite CHEBI:75772 S. cerevisiae metabolite ChEBI S. cerevisiae metabolites ChEBI S. cerevisiae secondary metabolite ChEBI S. cerevisiae secondary metabolites ChEBI Saccharomyces cerevisiae metabolites ChEBI Saccharomyces cerevisiae secondary metabolites ChEBI baker's yeast metabolite ChEBI baker's yeast metabolites ChEBI baker's yeast secondary metabolite ChEBI baker's yeast secondary metabolites ChEBI Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea. chebi_ontology prokaryotic metabolites CHEBI:75787 prokaryotic metabolite CHEBI:75787 prokaryotic metabolites ChEBI An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any aromatic amino-acid. chebi_ontology an aromatic amino-acid aromatic amino-acid zwitterions CHEBI:76042 aromatic amino-acid zwitterion CHEBI:76042 an aromatic amino-acid UniProt aromatic amino-acid zwitterions ChEBI Any metabolite produced by metabolism of a xenobiotic compound. chebi_ontology xenobiotic metabolites CHEBI:76206 xenobiotic metabolite CHEBI:76206 xenobiotic metabolites ChEBI A compressed gas or liquid with a boiling point lower than room temperature which to used to propel and dispense liquids such as deodorants, insecticides, paints, etc. from aerosol cans. chebi_ontology propellants CHEBI:76414 propellant CHEBI:76414 propellants ChEBI Any metabolite produced during a metabolic reaction in marine macro- and microorganisms. CHEBI:77078 chebi_ontology marine metabolites CHEBI:76507 marine metabolite CHEBI:76507 marine metabolites ChEBI A nitroso compound that is any urea in which one of the nitrogens is substituted by a nitroso group chebi_ontology CHEBI:76551 N-nitrosoureas CHEBI:76551 A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*). chebi_ontology EC 2.7.* (P-containing group transferase) inhibitors EC 2.7.* (phosphorus-containing group transferase) inhibitor EC 2.7.* (phosphorus-containing group transferase) inhibitors EC 2.7.* inhibitor EC 2.7.* inhibitors phosphorus-containing group transferase (EC 2.7.*) inhibitor phosphorus-containing group transferase (EC 2.7.*) inhibitors phosphorus-containing group transferase inhibitor phosphorus-containing group transferase inhibitors CHEBI:76668 EC 2.7.* (P-containing group transferase) inhibitor CHEBI:76668 EC 2.7.* (P-containing group transferase) inhibitors ChEBI EC 2.7.* (phosphorus-containing group transferase) inhibitor ChEBI EC 2.7.* (phosphorus-containing group transferase) inhibitors ChEBI EC 2.7.* inhibitor ChEBI EC 2.7.* inhibitors ChEBI phosphorus-containing group transferase (EC 2.7.*) inhibitor ChEBI phosphorus-containing group transferase (EC 2.7.*) inhibitors ChEBI phosphorus-containing group transferase inhibitor ChEBI phosphorus-containing group transferase inhibitors ChEBI An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*). chebi_ontology EC 5.99.* (miscellaneous isomerases) inhibitor EC 5.99.* (miscellaneous isomerases) inhibitors EC 5.99.* (other isomerase) inhibitor EC 5.99.* (other isomerase) inhibitors EC 5.99.* (other isomerases) inhibitors EC 5.99.* inhibitor EC 5.99.* inhibitors CHEBI:76697 EC 5.99.* (other isomerases) inhibitor CHEBI:76697 EC 5.99.* (miscellaneous isomerases) inhibitor ChEBI EC 5.99.* (miscellaneous isomerases) inhibitors ChEBI EC 5.99.* (other isomerase) inhibitor ChEBI EC 5.99.* (other isomerase) inhibitors ChEBI EC 5.99.* (other isomerases) inhibitors ChEBI EC 5.99.* inhibitor ChEBI EC 5.99.* inhibitors ChEBI An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*). Wikipedia:Oxidoreductase chebi_ontology EC 1.* (oxidoreductase) inhibitors EC 1.* inhibitor EC 1.* inhibitors oxidoreductase (EC 1.*) inhibitor oxidoreductase (EC 1.*) inhibitors oxidoreductase inhibitor oxidoreductase inhibitors CHEBI:76725 EC 1.* (oxidoreductase) inhibitor CHEBI:76725 EC 1.* (oxidoreductase) inhibitors ChEBI EC 1.* inhibitor ChEBI EC 1.* inhibitors ChEBI oxidoreductase (EC 1.*) inhibitor ChEBI oxidoreductase (EC 1.*) inhibitors ChEBI oxidoreductase inhibitor ChEBI oxidoreductase inhibitors ChEBI An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*). chebi_ontology EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors EC 1.5.* inhibitor EC 1.5.* inhibitors inhibitor of oxidoreductase acting on CH-NH group of donor inhibitor of oxidoreductase acting on CH-NH group of donors inhibitors of oxidoreductase acting on CH-NH group of donor inhibitors of oxidoreductase acting on CH-NH group of donors oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors CHEBI:76731 EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor CHEBI:76731 EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors ChEBI EC 1.5.* inhibitor ChEBI EC 1.5.* inhibitors ChEBI inhibitor of oxidoreductase acting on CH-NH group of donor ChEBI inhibitor of oxidoreductase acting on CH-NH group of donors ChEBI inhibitors of oxidoreductase acting on CH-NH group of donor ChEBI inhibitors of oxidoreductase acting on CH-NH group of donors ChEBI oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor ChEBI oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors ChEBI An oxidoreductase inhibitor which interferes with the action of an oxidoreductase of class EC 1.8.*.* (acting on a sulfur group of donors). chebi_ontology EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitors EC 1.8.* inhibitor EC 1.8.* inhibitors oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitor oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitors CHEBI:76735 EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor CHEBI:76735 EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitors ChEBI EC 1.8.* inhibitor ChEBI EC 1.8.* inhibitors ChEBI oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitor ChEBI oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitors ChEBI Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*). Wikipedia:Hydrolase chebi_ontology EC 3.* (hydrolase) inhibitors EC 3.* inhibitor EC 3.* inhibitors EC 3.*.*.* inhibitor EC 3.*.*.* inhibitors hydrolase (EC 3.*) inhibitor hydrolase (EC 3.*) inhibitors hydrolase inhibitor hydrolase inhibitors CHEBI:76759 EC 3.* (hydrolase) inhibitor CHEBI:76759 EC 3.* (hydrolase) inhibitors ChEBI EC 3.* inhibitor ChEBI EC 3.* inhibitors ChEBI EC 3.*.*.* inhibitor ChEBI EC 3.*.*.* inhibitors ChEBI hydrolase (EC 3.*) inhibitor ChEBI hydrolase (EC 3.*) inhibitors ChEBI hydrolase inhibitor ChEBI hydrolase inhibitors ChEBI A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*). chebi_ontology EC 3.1.* (ester hydrolase) inhibitors EC 3.1.* inhibitor EC 3.1.* inhibitors ester hydrolase (EC 3.1.*) inhibitor ester hydrolase (EC 3.1.*) inhibitors ester hydrolase inhibitor ester hydrolase inhibitors CHEBI:76760 EC 3.1.* (ester hydrolase) inhibitor CHEBI:76760 EC 3.1.* (ester hydrolase) inhibitors ChEBI EC 3.1.* inhibitor ChEBI EC 3.1.* inhibitors ChEBI ester hydrolase (EC 3.1.*) inhibitor ChEBI ester hydrolase (EC 3.1.*) inhibitors ChEBI ester hydrolase inhibitor ChEBI ester hydrolase inhibitors ChEBI Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*). chebi_ontology EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors EC 3.5.* inhibitor EC 3.5.* inhibitors CHEBI:76764 EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor CHEBI:76764 EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor ChEBI EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors ChEBI EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor ChEBI EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors ChEBI EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors ChEBI EC 3.5.* inhibitor ChEBI EC 3.5.* inhibitors ChEBI An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*). chebi_ontology EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors EC 3.1.3.* inhibitor EC 3.1.3.* inhibitors inhibitor of phosphoric monoester hydrolase inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors of phosphoric monoester hydrolase inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*) phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors phosphoric monoester hydrolase inhibitor phosphoric monoester hydrolase inhibitors CHEBI:76775 EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor CHEBI:76775 EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors ChEBI EC 3.1.3.* inhibitor ChEBI EC 3.1.3.* inhibitors ChEBI inhibitor of phosphoric monoester hydrolase ChEBI inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*) ChEBI inhibitors of phosphoric monoester hydrolase ChEBI inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*) ChEBI phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor ChEBI phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors ChEBI phosphoric monoester hydrolase inhibitor ChEBI phosphoric monoester hydrolase inhibitors ChEBI An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*). chebi_ontology EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors EC 3.5.1.* inhibitor EC 3.5.1.* inhibitors non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors CHEBI:76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor CHEBI:76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors ChEBI EC 3.5.1.* inhibitor ChEBI EC 3.5.1.* inhibitors ChEBI non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor ChEBI non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors ChEBI An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*). chebi_ontology EC 2.7.11.* (protein-serine/threonine kinase) inhibitors EC 2.7.11.* inhibitor EC 2.7.11.* inhibitors protein-serine/threonine kinase (EC 2.7.11.*) inhibitor protein-serine/threonine kinase (EC 2.7.11.*) inhibitors protein-serine/threonine kinase inhibitor protein-serine/threonine kinase inhibitors CHEBI:76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor CHEBI:76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitors ChEBI EC 2.7.11.* inhibitor ChEBI EC 2.7.11.* inhibitors ChEBI protein-serine/threonine kinase (EC 2.7.11.*) inhibitor ChEBI protein-serine/threonine kinase (EC 2.7.11.*) inhibitors ChEBI protein-serine/threonine kinase inhibitor ChEBI protein-serine/threonine kinase inhibitors ChEBI An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*). chebi_ontology EC 2.7.7.* (nucleotidyltransferase) inhibitors inhibitor of nucleotidyltransferases inhibitor of nucleotidyltransferases (EC 2.7.7.*) inhibitors of nucleotidyltransferases inhibitors of nucleotidyltransferases (EC 2.7.7.*) nucleotidyltransferase (EC 2.7.7.*) inhibitor nucleotidyltransferase (EC 2.7.7.*) inhibitors nucleotidyltransferase inhibitor nucleotidyltransferase inhibitors CHEBI:76815 EC 2.7.7.* (nucleotidyltransferase) inhibitor CHEBI:76815 EC 2.7.7.* (nucleotidyltransferase) inhibitors ChEBI inhibitor of nucleotidyltransferases ChEBI inhibitor of nucleotidyltransferases (EC 2.7.7.*) ChEBI inhibitors of nucleotidyltransferases ChEBI inhibitors of nucleotidyltransferases (EC 2.7.7.*) ChEBI nucleotidyltransferase (EC 2.7.7.*) inhibitor ChEBI nucleotidyltransferase (EC 2.7.7.*) inhibitors ChEBI nucleotidyltransferase inhibitor ChEBI nucleotidyltransferase inhibitors ChEBI An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*). chebi_ontology EC 6.3.1.* (acid-ammonia/amine ligase) inhibitors EC 6.3.1.* inhibitor EC 6.3.1.* inhibitors acid-ammonia (or amine) ligase inhibitor acid-ammonia (or amine) ligase inhibitors CHEBI:76823 EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor CHEBI:76823 EC 6.3.1.* (acid-ammonia/amine ligase) inhibitors ChEBI EC 6.3.1.* inhibitor ChEBI EC 6.3.1.* inhibitors ChEBI acid-ammonia (or amine) ligase inhibitor ChEBI acid-ammonia (or amine) ligase inhibitors ChEBI An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class. chebi_ontology EC 5.99.1.* (miscellaneous isomerase) inhibitors EC 5.99.1.* inhibitor EC 5.99.1.* inhibitors CHEBI:76830 EC 5.99.1.* (miscellaneous isomerase) inhibitor CHEBI:76830 EC 5.99.1.* (miscellaneous isomerase) inhibitors ChEBI EC 5.99.1.* inhibitor ChEBI EC 5.99.1.* inhibitors ChEBI An EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.5.1.*). chebi_ontology EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors EC 1.5.1.* inhibitor EC 1.5.1.* inhibitors oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors CHEBI:76863 EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor CHEBI:76863 EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors ChEBI EC 1.5.1.* inhibitor ChEBI EC 1.5.1.* inhibitors ChEBI oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor ChEBI oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors ChEBI An EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.8.1.*). chebi_ontology EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitors EC 1.8.1.* inhibitor EC 1.8.1.* inhibitors oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitor oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitors CHEBI:76869 EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor CHEBI:76869 EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitors ChEBI EC 1.8.1.* inhibitor ChEBI EC 1.8.1.* inhibitors ChEBI oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitor ChEBI oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitors ChEBI Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. CHEBI:75766 CHEBI:76925 chebi_ontology plant metabolites plant secondary metabolites CHEBI:76924 plant metabolite CHEBI:76924 plant metabolites ChEBI plant secondary metabolites ChEBI Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds. CHEBI:75765 CHEBI:76947 chebi_ontology fungal metabolites CHEBI:76946 fungal metabolite CHEBI:76946 fungal metabolites ChEBI Any human metabolite produced by metabolism of a xenobiotic compound in humans. chebi_ontology human xenobiotic metabolites CHEBI:76967 human xenobiotic metabolite CHEBI:76967 human xenobiotic metabolites ChEBI Any prokaryotic metabolite produced during a metabolic reaction in bacteria. CHEBI:75760 CHEBI:76970 chebi_ontology CHEBI:76969 bacterial metabolite CHEBI:76969 Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. chebi_ontology E.coli metabolite E.coli metabolites Escherichia coli metabolites CHEBI:76971 Escherichia coli metabolite CHEBI:76971 E.coli metabolite ChEBI E.coli metabolites ChEBI Escherichia coli metabolites ChEBI An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12). Wikipedia:Trypanothione-disulfide_reductase chebi_ontology EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors EC 1.8.1.12 inhibitor EC 1.8.1.12 inhibitors N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitor N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitors NADPH2:trypanothione oxidoreductase inhibitor NADPH2:trypanothione oxidoreductase inhibitors NADPH:trypanothione oxidoreductase inhibitor NADPH:trypanothione oxidoreductase inhibitors trypanothione reductase inhibitor trypanothione reductase inhibitors trypanothione-disulfide reductase (EC 1.8.1.12) inhibitor trypanothione-disulfide reductase (EC 1.8.1.12) inhibitors trypanothione:NADP(+) oxidoreductase inhibitor trypanothione:NADP(+) oxidoreductase inhibitors CHEBI:77402 EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor CHEBI:77402 EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors ChEBI EC 1.8.1.12 inhibitor ChEBI EC 1.8.1.12 inhibitors ChEBI N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitor ChEBI N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitors ChEBI NADPH2:trypanothione oxidoreductase inhibitor ChEBI NADPH2:trypanothione oxidoreductase inhibitors ChEBI NADPH:trypanothione oxidoreductase inhibitor ChEBI NADPH:trypanothione oxidoreductase inhibitors ChEBI trypanothione reductase inhibitor ChEBI trypanothione reductase inhibitors ChEBI trypanothione-disulfide reductase (EC 1.8.1.12) inhibitor ChEBI trypanothione-disulfide reductase (EC 1.8.1.12) inhibitors ChEBI trypanothione:NADP(+) oxidoreductase inhibitor ChEBI trypanothione:NADP(+) oxidoreductase inhibitors ChEBI Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). CHEBI:75770 CHEBI:77123 chebi_ontology H. sapiens metabolite H. sapiens metabolites Homo sapiens metabolite Homo sapiens metabolites CHEBI:77746 human metabolite CHEBI:77746 H. sapiens metabolite ChEBI H. sapiens metabolites ChEBI Homo sapiens metabolite ChEBI Homo sapiens metabolites ChEBI An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4). Wikipedia:Amidase chebi_ontology EC 3.5.1.4 (amidase) inhibitors EC 3.5.1.4 inhibitor EC 3.5.1.4 inhibitors N-acetylaminohydrolase inhibitor N-acetylaminohydrolase inhibitors acylamidase inhibitor acylamidase inhibitors acylamide amidohydrolase inhibitor acylamide amidohydrolase inhibitors amidase (EC 3.5.1.4) inhibitor amidase (EC 3.5.1.4) inhibitors amidase inhibitor amidase inhibitors amidohydrolase inhibitor amidohydrolase inhibitors deaminase inhibitor deaminase inhibitors fatty acylamidase inhibitor fatty acylamidase inhibitors CHEBI:77941 EC 3.5.1.4 (amidase) inhibitor CHEBI:77941 EC 3.5.1.4 (amidase) inhibitors ChEBI EC 3.5.1.4 inhibitor ChEBI EC 3.5.1.4 inhibitors ChEBI N-acetylaminohydrolase inhibitor ChEBI N-acetylaminohydrolase inhibitors ChEBI acylamidase inhibitor ChEBI acylamidase inhibitors ChEBI acylamide amidohydrolase inhibitor ChEBI acylamide amidohydrolase inhibitors ChEBI amidase (EC 3.5.1.4) inhibitor ChEBI amidase (EC 3.5.1.4) inhibitors ChEBI amidase inhibitor ChEBI amidase inhibitors ChEBI amidohydrolase inhibitor ChEBI amidohydrolase inhibitors ChEBI deaminase inhibitor ChEBI deaminase inhibitors ChEBI fatty acylamidase inhibitor ChEBI fatty acylamidase inhibitors ChEBI An antioxidant that used as a food additives to help guard against food deterioration. chebi_ontology food antioxidants CHEBI:77962 food antioxidant CHEBI:77962 food antioxidants ChEBI A food additive that intensifies, retains or stabilises the colour of a food. Wikipedia:Colour_retention_agent chebi_ontology color retention agent color retention agents colour retention agent colour retention agents food color retention agent food color retention agents food colour retention agents CHEBI:78006 food colour retention agent CHEBI:78006 color retention agent ChEBI color retention agents ChEBI colour retention agent ChEBI colour retention agents ChEBI food color retention agent ChEBI food color retention agents ChEBI food colour retention agents ChEBI A propellant that is used to expel foods from an aerosol container. chebi_ontology food propellants CHEBI:78017 food propellant CHEBI:78017 food propellants ChEBI A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants. chebi_ontology dietary component dietary components food components CHEBI:78295 food component CHEBI:78295 dietary component ChEBI dietary components ChEBI food components ChEBI Any minor or unwanted substance introduced into the environment that can have undesired effects. chebi_ontology environmental contaminants CHEBI:78298 environmental contaminant CHEBI:78298 environmental contaminants ChEBI A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure. Wikipedia:Refrigerant chebi_ontology refrigerants CHEBI:78433 refrigerant CHEBI:78433 refrigerants ChEBI Any compound that causes severe skin, eye and mucosal pain and irritation. Wikipedia:Blister_agent chebi_ontology blister agent blister agents vesicants CHEBI:78592 vesicant CHEBI:78592 blister agent ChEBI blister agents ChEBI vesicants ChEBI An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3. CHEBI:83409 chebi_ontology alpha-amino acid zwitterion alpha-amino acid zwitterions alpha-amino-acid zwitterions an alpha-amino acid CHEBI:78608 alpha-amino-acid zwitterion CHEBI:78608 alpha-amino acid zwitterion ChEBI alpha-amino acid zwitterions ChEBI alpha-amino-acid zwitterions ChEBI an alpha-amino acid UniProt Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation. chebi_ontology carbohydrates and derivatives carbohydrates and their derivatives CHEBI:78616 carbohydrates and carbohydrate derivatives CHEBI:78616 carbohydrates and derivatives ChEBI carbohydrates and their derivatives ChEBI Any metabolite produced by all living cells. chebi_ontology essential metabolite essential metabolites fundamental metabolites CHEBI:78675 fundamental metabolite CHEBI:78675 essential metabolite ChEBI essential metabolites ChEBI fundamental metabolites ChEBI Any inorganic anion with a valency of three. chebi_ontology trivalent inorganic anions CHEBI:79387 trivalent inorganic anion CHEBI:79387 trivalent inorganic anions ChEBI Any inorganic anion with a valency of two. chebi_ontology divalent inorganic anions CHEBI:79388 divalent inorganic anion CHEBI:79388 divalent inorganic anions ChEBI Any inorganic anion with a valency of one. chebi_ontology monovalent inorganic anions CHEBI:79389 monovalent inorganic anion CHEBI:79389 monovalent inorganic anions ChEBI An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill. chebi_ontology crustacean metabolites CHEBI:83039 crustacean metabolite CHEBI:83039 crustacean metabolites ChEBI A Daphnia metabolite produced by the species Daphnia magna. chebi_ontology Daphnia magna metabolites CHEBI:83056 Daphnia magna metabolite CHEBI:83056 Daphnia magna metabolites ChEBI A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia Wikipedia:Daphnia chebi_ontology Daphnia metabolites CHEBI:83057 Daphnia metabolite CHEBI:83057 Daphnia metabolites ChEBI An ester resulting from the formal condensation of the hydroxy group of an alcohol, phenol, heteroarenol, or enol with an organosulfonic acid. chebi_ontology organosulfonate ester organosulfonate esters organosulfonic esters CHEBI:83347 organosulfonic ester CHEBI:83347 organosulfonate ester ChEBI organosulfonate esters ChEBI organosulfonic esters ChEBI An organosulfate oxoanion obtained by deprotonation of the sulfo group of any alkyl sulfate; major species at pH 7.3. chebi_ontology alkyl sulfate anion an alkyl sulfate CHEBI:83414 alkyl sulfate(1-) CHEBI:83414 alkyl sulfate anion ChEBI an alkyl sulfate UniProt Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom. chebi_ontology canonical amino acid derivative canonical amino acid derivatives canonical amino-acid derivative canonical amino-acid derivatives proteinogenic amino acid derivatives proteinogenic amino-acid derivative proteinogenic amino-acid derivatives CHEBI:83811 proteinogenic amino acid derivative CHEBI:83811 canonical amino acid derivative ChEBI canonical amino acid derivatives ChEBI canonical amino-acid derivative ChEBI canonical amino-acid derivatives ChEBI proteinogenic amino acid derivatives ChEBI proteinogenic amino-acid derivative ChEBI proteinogenic amino-acid derivatives ChEBI Any derivative of a non-proteinogenic amino acid resulting from reaction at an amino group or carboxy group, or from the replacement of any hydrogen by a heteroatom. chebi_ontology non-canonical amino acid derivative non-canonical amino-acid derivatives non-proteinogenic amino-acid derivatives CHEBI:83812 non-proteinogenic amino acid derivative CHEBI:83812 non-canonical amino acid derivative ChEBI non-canonical amino-acid derivatives ChEBI non-proteinogenic amino-acid derivatives ChEBI Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration. Wikipedia:Proteinogenic_amino_acid chebi_ontology canonical amino acid canonical amino acids proteinogenic amino acids CHEBI:83813 proteinogenic amino acid CHEBI:83813 canonical amino acid ChEBI canonical amino acids ChEBI proteinogenic amino acids ChEBI Any amino-acid that is not naturally encoded in the genetic code of any organism. Wikipedia:Non-proteinogenic_amino_acids chebi_ontology non-canonical amino acid non-canonical amino acids non-canonical amino-acid non-canonical amino-acids non-coded amino acid non-coded amino acids non-coded amino-acid non-coded amino-acids non-proteinogenic amino acids non-proteinogenic amino-acid non-proteinogenic amino-acids CHEBI:83820 non-proteinogenic amino acid CHEBI:83820 non-canonical amino acid ChEBI non-canonical amino acids ChEBI non-canonical amino-acid ChEBI non-canonical amino-acids ChEBI non-coded amino acid ChEBI non-coded amino acids ChEBI non-coded amino-acid ChEBI non-coded amino-acids ChEBI non-proteinogenic amino acids ChEBI non-proteinogenic amino-acid ChEBI non-proteinogenic amino-acids ChEBI Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues. CHEBI:25359 chebi_ontology amino acid derivative amino acid derivatives amino-acid derivatives modified amino acids CHEBI:83821 amino-acid derivative CHEBI:83821 amino acid derivative ChEBI amino acid derivatives ChEBI amino-acid derivatives ChEBI modified amino acids ChEBI Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids. chebi_ontology non-proteinogenic L-alpha-amino acids CHEBI:83822 non-proteinogenic L-alpha-amino acid CHEBI:83822 non-proteinogenic L-alpha-amino acids ChEBI Any alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids. chebi_ontology non-proteinogenic alpha-amino acids non-proteinogenic alpha-amino-acid non-proteinogenic alpha-amino-acids CHEBI:83925 non-proteinogenic alpha-amino acid CHEBI:83925 non-proteinogenic alpha-amino acids ChEBI non-proteinogenic alpha-amino-acid ChEBI non-proteinogenic alpha-amino-acids ChEBI A proteinogenic amino acid derivative resulting from reaction of L-glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of L-glutamic acid by a heteroatom. chebi_ontology L-glutamic acid derivatives CHEBI:83982 L-glutamic acid derivative CHEBI:83982 L-glutamic acid derivatives ChEBI Any metabolite (endogenous or exogenous) found in human urine samples. chebi_ontology human urinary metabolites CHEBI:84087 human urinary metabolite CHEBI:84087 human urinary metabolites ChEBI A non-proteinogenic amino acid derivative resulting from reaction of D-phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of D-phenylalanine by a heteroatom. chebi_ontology D-phenylalanine derivatives CHEBI:84143 D-phenylalanine derivative CHEBI:84143 D-phenylalanine derivatives ChEBI A proteinogenic amino acid derivative resulting from reaction of L-phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-phenylalanine by a heteroatom. chebi_ontology L-phenylalanine derivatives CHEBI:84144 L-phenylalanine derivative CHEBI:84144 L-phenylalanine derivatives ChEBI Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae. chebi_ontology algal metabolites CHEBI:84735 algal metabolite CHEBI:84735 algal metabolites ChEBI Any cosmetic used to lighten the colour of skin by reducing the concentration of melanin. Wikipedia:Skin_whitening chebi_ontology melanogenesis inhibitor melanogenesis inhibitors skin bleaching agent skin bleaching agents skin depigmenting agent skin depigmenting agents skin lightening agents skin whitening agent skin whitening agents CHEBI:85046 skin lightening agent CHEBI:85046 melanogenesis inhibitor ChEBI melanogenesis inhibitors ChEBI skin bleaching agent ChEBI skin bleaching agents ChEBI skin depigmenting agent ChEBI skin depigmenting agents ChEBI skin lightening agents ChEBI skin whitening agent ChEBI skin whitening agents ChEBI Any metabolite (endogenous or exogenous) found in human blood serum samples. chebi_ontology human blood serum metabolites CHEBI:85234 human blood serum metabolite CHEBI:85234 human blood serum metabolites ChEBI A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9. DrugBank:DB01103 HMDB:HMDB0015235 KEGG:C07339 KEGG:D08179 LINCS:LSM-1577 MetaCyc:ATABRINE Wikipedia:Quinacrine Quinacrine chebi_ontology 2-methoxy-6-chloro-9-diethylaminopentylaminoacridine 3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine Mepacrine N(4)-(6-chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine mepacrine CHEBI:8711 quinacrine CHEBI:8711 Quinacrine KEGG_COMPOUND 2-methoxy-6-chloro-9-diethylaminopentylaminoacridine ChemIDplus 3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine ChemIDplus 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine ChemIDplus Mepacrine KEGG_COMPOUND N(4)-(6-chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine ChemIDplus mepacrine ChemIDplus Any metal which causes the onset of an allergic reaction. chebi_ontology allergenic metal allergenic metals metal allergens CHEBI:88184 metal allergen CHEBI:88184 allergenic metal ChEBI allergenic metals ChEBI metal allergens ChEBI Any drug which causes the onset of an allergic reaction. chebi_ontology allergenic drug CHEBI:88188 drug allergen CHEBI:88188 allergenic drug ChEBI A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors. CHEBI:189678 Wikipedia:Receptor_modulator chebi_ontology receptor modulators CHEBI:90710 receptor modulator CHEBI:90710 receptor modulators ChEBI A carboxylic acic anion obtained by deprotonation of the carboxy group of any aromatic carboxylic acid. Major species at pH 7.3. chebi_ontology an aromatic carboxylate CHEBI:91007 aromatic carboxylate CHEBI:91007 an aromatic carboxylate UniProt FlyBase miscellaneous controlled vocabulary term. FlyBase miscellaneous CV FBcv:0000000 FlyBase CV FBcv:0000000 pub_type FBcv:0000001 This term was obsoleted because it was only ever used to annotate one publication: A copy of Calvin Bridges death certificate. This can still be found in the Drosophila offprint collection (FBrf0186653). obsolete death certificate true FBcv:0000001 Phenotype that is any abnormality in thermotaxis (GO:0043052). 'thermotaxis' is defined as: 'The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.' thermotaxis behavior defective thermotaxis behaviour defective thermotaxis defective phenotypic_class FBcv:0000002 abnormal thermotaxis FBcv:0000002 Phenotype that is any abnormality in thermotaxis (GO:0043052). 'thermotaxis' is defined as: 'The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.' FBC:DOS GOC:cab1 WB_REF:cgc467 mode_of_assay FBcv:0000003 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete In transgenic Drosophila (intraspecific) true FBcv:0000003 mode_of_assay FBcv:0000004 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete Whole-organism transient assay (intraspecific) true FBcv:0000004 Term used to qualify a descriptor. FlyBase miscellaneous CV FBcv:0000005 qualifier FBcv:0000005 Term used to qualify a descriptor. FBC:MMC A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating, but only to > 50% of wild-type. phenotypic_class FBcv:0000006 male semi-fertile FBcv:0000006 A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating, but only to > 50% of wild-type. FBC:AO FBC:CP FBC:DOS A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating, but only to > 50% of wild-type. phenotypic_class FBcv:0000007 female semi-fertile FBcv:0000007 A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating, but only to > 50% of wild-type. FBC:AO FBC:CP FBC:DOS Genotype g1 is a modifier of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is significantly different from that caused by g2 alone. phenotypic_class variegation FBcv:0000008 modifier of variegation FBcv:0000008 Genotype g1 is a modifier of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is significantly different from that caused by g2 alone. FBC:DOS variegation FBC:DOS temporal_qualifier FBcv:0000009 This term has been obsoleted because all of its children terms have been obsoleted [FBC:MMC]. mc161027 obsolete temporal stage qualifier true FBcv:0000009 FlyBase miscellaneous CV FBcv:0000010 This term has been obsoleted because there are new terms to replace it [FBC:MMC]. mc160113 obsolete monophasic true FBcv:0000010 temporal_qualifier FBcv:0000011 This term has been obsoleted because all of its children terms have been obsoleted [FBC:MMC]. mc161027 obsolete relative temporal qualifier true FBcv:0000011 FlyBase miscellaneous CV FBcv:0000012 This term has been obsoleted because both of its children terms have been obsoleted [FBC:MMC]. mc160113 obsolete absolute temporal qualifier true FBcv:0000012 Term that describes an allele, balancer, group or publication. FlyBase miscellaneous CV FBcv:0000013 descriptor FBcv:0000013 Term that describes an allele, balancer, group or publication. FBC:MMC Qualifier used to describe changes in number or location of an anatomical structure compared to wild type. structural_qualifier FBcv:0000014 structural qualifier FBcv:0000014 Qualifier used to describe changes in number or location of an anatomical structure compared to wild type. FBC:CP FBC:MMC pub_type FBcv:0000015 This term was obsoleted because it was little used. obsolete postage stamp true FBcv:0000015 FlyBase miscellaneous CV FBcv:0000016 Consider - FBsv:0000605. obsolete Baylor TE recombination mapping kit stock true FBcv:0000016 Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. FlyBase miscellaneous CV FBcv:0000017 obsolete penetrance qualifier true FBcv:0000017 Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. ISBN:978-0-7167-3520-5 Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is complete when all the individuals of a given genotype exhibit the phenotype associated with that genotype. FlyBase miscellaneous CV FBcv:0000018 obsolete penetrance complete true FBcv:0000018 Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is complete when all the individuals of a given genotype exhibit the phenotype associated with that genotype. ISBN:978-0-7167-3520-5 Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is incomplete when only some the individuals of a given genotype exhibit the phenotype associated with that genotype. FlyBase miscellaneous CV FBcv:0000019 obsolete penetrance incomplete true FBcv:0000019 Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is incomplete when only some the individuals of a given genotype exhibit the phenotype associated with that genotype. ISBN:978-0-7167-3520-5 Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is incomplete when only a percentage of the individuals of a given genotype exhibit the phenotype associated with that genotype. FlyBase miscellaneous CV FBcv:0000020 This term should be modified by a % value. This is not currently possible in FlyBase curation. obsolete penetrance percent true FBcv:0000020 Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is incomplete when only a percentage of the individuals of a given genotype exhibit the phenotype associated with that genotype. ISBN:978-0-7167-3520-5 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. FlyBase miscellaneous CV FBcv:0000021 obsolete expressivity qualifier true FBcv:0000021 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. ISBN:978-0-7167-3520-5 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. Expressivity is complete when an individual of a given genotype expresses the full phenotype associated with that genotype. FlyBase miscellaneous CV FBcv:0000022 obsolete expressivity complete true FBcv:0000022 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. Expressivity is complete when an individual of a given genotype expresses the full phenotype associated with that genotype. ISBN:978-0-7167-3520-5 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. Expressivity is incomplete when an individual of a given genotype expresses only partially the phenotype associated with that genotype. FlyBase miscellaneous CV FBcv:0000023 obsolete expressivity incomplete true FBcv:0000023 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. Expressivity is incomplete when an individual of a given genotype expresses only partially the phenotype associated with that genotype. ISBN:978-0-7167-3520-5 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. 'High expressivity' conveys that while expressivity is not complete, the phenotype expressed is approaching that of complete expressivity. FlyBase miscellaneous CV FBcv:0000024 obsolete expressivity high true FBcv:0000024 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. 'High expressivity' conveys that while expressivity is not complete, the phenotype expressed is approaching that of complete expressivity. ISBN:978-0-7167-3520-5 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. 'Low expressivity' conveys that phenotype expressed is a much reduced version compared to complete expressivity. FlyBase miscellaneous CV FBcv:0000025 obsolete expressivity low true FBcv:0000025 Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. 'Low expressivity' conveys that phenotype expressed is a much reduced version compared to complete expressivity. ISBN:978-0-7167-3520-5 FlyBase miscellaneous CV FBcv:0000026 obsolete recessive visible allele recombination mapping stock true FBcv:0000026 FlyBase miscellaneous CV FBcv:0000027 obsolete dominant visible allele recombination mapping stock true FBcv:0000027 FlyBase miscellaneous CV FBcv:0000028 Consider - FBsv:0001018. obsolete SNP recombination mapping stock true FBcv:0000028 FlyBase miscellaneous CV FBcv:0000029 obsolete transposable element mutagenesis stock true FBcv:0000029 spatial_qualifier FBcv:0000030 This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027 obsolete compartment true FBcv:0000030 spatial_qualifier FBcv:0000031 This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027 obsolete anterior compartment true FBcv:0000031 spatial_qualifier FBcv:0000032 This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027 obsolete compartment boundary true FBcv:0000032 spatial_qualifier FBcv:0000033 This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027 obsolete anterior/posterior compartment boundary true FBcv:0000033 spatial_qualifier FBcv:0000034 This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027 obsolete dorsal/ventral compartment boundary true FBcv:0000034 spatial_qualifier FBcv:0000035 This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027 obsolete dorsal compartment true FBcv:0000035 spatial_qualifier FBcv:0000036 This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027 obsolete posterior compartment true FBcv:0000036 spatial_qualifier FBcv:0000037 This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027 obsolete ventral compartment true FBcv:0000037 Qualifier that describes the spatial characteristics of a phenotype or expression pattern relative to the position of another entity. PATO:0001631 spatial_qualifier FBcv:0000038 relative spatial qualifier FBcv:0000038 Qualifier that describes the spatial characteristics of a phenotype or expression pattern relative to the position of another entity. FBC:CP A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front of an organism relative to another entity. PATO:0001632 spatial_qualifier FBcv:0000039 anterior to FBcv:0000039 A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front of an organism relative to another entity. PATO:0001632 A spatial quality inhering in a bearer by virtue of the bearer's being located further from a more centrally located entity. PATO:0001234 spatial_qualifier FBcv:0000040 distal to FBcv:0000040 A spatial quality inhering in a bearer by virtue of the bearer's being located further from a more centrally located entity. PATO:0001234 A spatial quality inhering in a bearer by virtue of the bearer's being located toward the back or upper surface of an organism relative to another entity. PATO:0001233 spatial_qualifier FBcv:0000041 dorsal to FBcv:0000041 A spatial quality inhering in a bearer by virtue of the bearer's being located toward the back or upper surface of an organism relative to another entity. PATO:0001233 FlyBase miscellaneous CV deletion kit stock FBcv:0000042 obsolete deficiency kit stock true FBcv:0000042 FlyBase miscellaneous CV FBcv:0000043 Consider - FBsv:0001020. obsolete transposase source for transposable element mutagenesis true FBcv:0000043 FlyBase miscellaneous CV FBcv:0000044 Consider - FBsv:0001022. obsolete ammunition source for transposable element mutagenesis true FBcv:0000044 A spatial quality inhering in a bearer by virtue of the bearer's being located toward the rear of an organism relative to another entity. PATO:0001633 spatial_qualifier FBcv:0000045 posterior to FBcv:0000045 A spatial quality inhering in a bearer by virtue of the bearer's being located toward the rear of an organism relative to another entity. PATO:0001633 temporal_qualifier FBcv:0000046 precursor FBcv:0000046 A spatial quality inhering in a bearer by virtue of the bearer's being located more centrally than another entity. PATO:0001195 spatial_qualifier FBcv:0000047 proximal to FBcv:0000047 A spatial quality inhering in a bearer by virtue of the bearer's being located more centrally than another entity. PATO:0001195 A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously. PATO:0001772 spatial_qualifier FBcv:0000048 surrounding FBcv:0000048 A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously. PATO:0001772 A spatial quality inhering in a bearer by virtue of the bearer's being located toward the belly or lower surface of an organism relative to another entity. PATO:0001196 spatial_qualifier FBcv:0000049 ventral to FBcv:0000049 A spatial quality inhering in a bearer by virtue of the bearer's being located toward the belly or lower surface of an organism relative to another entity. FBC:CP A spatial quality inhering in a bearer by virtue of the bearer's being located near in space in relation to another entity. PATO:0002259 adjacent to spatial_qualifier FBcv:0000050 vicinity of FBcv:0000050 A spatial quality inhering in a bearer by virtue of the bearer's being located near in space in relation to another entity. PATO:0002259 adjacent to PATO:0002259 Present in the area that separates segments. spatial_qualifier FBcv:0000051 segment boundary FBcv:0000051 Present in the area that separates segments. FBC:MMC Qualifier that describes the spatial characteristics of a phenotype or expression pattern. spatial_qualifier FBcv:0000052 spatial qualifier FBcv:0000052 Qualifier that describes the spatial characteristics of a phenotype or expression pattern. FBC:MMC Restricted to anterior region of some specified type. spatial_qualifier FBcv:0000053 anterior FBcv:0000053 Restricted to anterior region of some specified type. FBC:DS Restricted to apical region of some specified type. spatial_qualifier FBcv:0000054 apical FBcv:0000054 Restricted to apical region of some specified type. FBC:DS Restricted to basal region of some specified type. spatial_qualifier FBcv:0000055 basal FBcv:0000055 Restricted to basal region of some specified type. FBC:DS Restricted to central region of some specified type. spatial_qualifier FBcv:0000056 central FBcv:0000056 Restricted to central region of some specified type. FBC:DS spatial_qualifier FBcv:0000057 This term has been obsoleted because there is no way to combine it with an anatomy term to produce a meaningful statement [FBC:MMC]. mc160113. obsolete contralateral true FBcv:0000057 Restricted to distal region of some specified type. spatial_qualifier FBcv:0000058 distal FBcv:0000058 Restricted to distal region of some specified type. FBC:DS Restricted to dorsal region of some specified type. spatial_qualifier FBcv:0000059 dorsal FBcv:0000059 Restricted to dorsal region of some specified type. FBC:DS Restricted to dorso-lateral region of some specified type. spatial_qualifier FBcv:0000060 dorso-lateral FBcv:0000060 Restricted to dorso-lateral region of some specified type. FBC:DS Anatomical structure is present in a location in which it would not be present in wild-type. PATO:0000628 structural_qualifier FBcv:0000061 An extra copy of an anatomical structure that is present in the same location as in wild-type should use 'increased number', rather than 'ectopic'. ectopic FBcv:0000061 Anatomical structure is present in a location in which it would not be present in wild-type. FBC:CP spatial_qualifier FBcv:0000062 This term has been obsoleted because there is no way to combine it with an anatomy term to produce a meaningful statement [FBC:MMC]. mc161027 obsolete ipsilateral true FBcv:0000062 Restricted to lateral region(s) of some specified type. spatial_qualifier FBcv:0000063 lateral FBcv:0000063 Restricted to lateral region(s) of some specified type. FBC:DS Restricted to medial region of some specified type. spatial_qualifier FBcv:0000064 medial FBcv:0000064 Restricted to medial region of some specified type. FBC:DS Restricted to posterior region of some specified type. spatial_qualifier FBcv:0000065 posterior FBcv:0000065 Restricted to posterior region of some specified type. FBC:DS Restricted to proximal region of some specified type. spatial_qualifier FBcv:0000066 proximal FBcv:0000066 Restricted to proximal region of some specified type. FBC:DS Restricted to unknown part(s) of a specified type. spatial_qualifier FBcv:0000067 restricted FBcv:0000067 Restricted to unknown part(s) of a specified type. FBC:DS Present in the correct location but in larger numbers than in wild-type. supernumerary structural_qualifier FBcv:0000068 increased number FBcv:0000068 Present in the correct location but in larger numbers than in wild-type. FBC:DOS Expressed everywhere at some specified stage. spatial_qualifier FBcv:0000069 ubiquitous FBcv:0000069 Expressed everywhere at some specified stage. FBC:DOS Restricted to ventral region of some specified type. spatial_qualifier FBcv:0000070 ventral FBcv:0000070 Restricted to ventral region of some specified type. FBC:DS Restricted to ventro-lateral region of some specified type. spatial_qualifier FBcv:0000071 ventro-lateral FBcv:0000071 Restricted to ventro-lateral region of some specified type. FBC:DS FlyBase miscellaneous CV FBcv:0000072 obsolete gene expression qualifier true FBcv:0000072 FlyBase miscellaneous CV FBcv:0000073 obsolete embryonic expression pattern true FBcv:0000073 Position in the egg or pre-gastrula embryo expressed as a percentage of egg length, where 0% corresponds to the posterior tip and 100% to the anterior tip. spatial_qualifier FBcv:0000074 egg length FBcv:0000074 Position in the egg or pre-gastrula embryo expressed as a percentage of egg length, where 0% corresponds to the posterior tip and 100% to the anterior tip. FBC:DOS At the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000075 0% egg length FBcv:0000075 At the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 0-10% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000076 0-10% egg length FBcv:0000076 0-10% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS The full length of the pre-gastrula embryo. spatial_qualifier FBcv:0000077 0-100% egg length FBcv:0000077 The full length of the pre-gastrula embryo. FBC:DOS 0-20% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000078 0-20% egg length FBcv:0000078 0-20% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 0-30% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000079 0-30% egg length FBcv:0000079 0-30% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 0-40% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000080 0-40% egg length FBcv:0000080 0-40% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 0-50% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000081 0-50% egg length FBcv:0000081 0-50% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 0-60% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000082 0-60% egg length FBcv:0000082 0-60% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 0-70% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000083 0-70% egg length FBcv:0000083 0-70% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 0-80% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000084 0-80% egg length FBcv:0000084 0-80% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 0-90% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000085 0-90% egg length FBcv:0000085 0-90% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 10% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000086 10% egg length FBcv:0000086 10% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 10-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000087 10-100% egg length FBcv:0000087 10-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 10-20% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000088 10-20% egg length FBcv:0000088 10-20% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 10-30% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000089 10-30% egg length FBcv:0000089 10-30% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 10-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000090 10-40% egg length FBcv:0000090 10-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 10-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000091 10-50% egg length FBcv:0000091 10-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 10-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000092 10-60% egg length FBcv:0000092 10-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 10-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000093 10-70% egg length FBcv:0000093 10-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 10-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000094 10-80% egg length FBcv:0000094 10-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 10-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000095 10-90% egg length FBcv:0000095 10-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS At the anterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000096 100% egg length FBcv:0000096 At the anterior tip of the egg or pre-gastrula embryo. FBC:DOS 20% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000097 20% egg length FBcv:0000097 20% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 20-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000098 20-100% egg length FBcv:0000098 20-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 20-30% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000099 20-30% egg length FBcv:0000099 20-30% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 20-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000100 20-40% egg length FBcv:0000100 20-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 20-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000101 20-50% egg length FBcv:0000101 20-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 20-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000102 20-60% egg length FBcv:0000102 20-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 20-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000103 20-70% egg length FBcv:0000103 20-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 20-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000104 20-80% egg length FBcv:0000104 20-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 20-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000105 20-90% egg length FBcv:0000105 20-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 30% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000106 30% egg length FBcv:0000106 30% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 30-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000107 30-100% egg length FBcv:0000107 30-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 30-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000108 30-40% egg length FBcv:0000108 30-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 30-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000109 30-50% egg length FBcv:0000109 30-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 30-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000110 30-60% egg length FBcv:0000110 30-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 30-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000111 30-70% egg length FBcv:0000111 30-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 30-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000112 30-80% egg length FBcv:0000112 30-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 30-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000113 30-90% egg length FBcv:0000113 30-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 40% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000114 40% egg length FBcv:0000114 40% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 40-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000115 40-100% egg length FBcv:0000115 40-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 40-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000116 40-50% egg length FBcv:0000116 40-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 40-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000117 40-60% egg length FBcv:0000117 40-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 40-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000118 40-70% egg length FBcv:0000118 40-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 40-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000119 40-80% egg length FBcv:0000119 40-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 40-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000120 40-90% egg length FBcv:0000120 40-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 50% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000121 50% egg length FBcv:0000121 50% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 50-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000122 50-100% egg length FBcv:0000122 50-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 50-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000123 50-60% egg length FBcv:0000123 50-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 50-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000124 50-70% egg length FBcv:0000124 50-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 50-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000125 50-80% egg length FBcv:0000125 50-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 50-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000126 50-90% egg length FBcv:0000126 50-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 60% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000127 60% egg length FBcv:0000127 60% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 60-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000128 60-100% egg length FBcv:0000128 60-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 60-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000129 60-80% egg length FBcv:0000129 60-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 60-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000130 60-90% egg length FBcv:0000130 60-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 70% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000131 70% egg length FBcv:0000131 70% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 70-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000132 70-100% egg length FBcv:0000132 70-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 70-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000133 70-80% egg length FBcv:0000133 70-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 70-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000134 70-90% egg length FBcv:0000134 70-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 80% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000135 80% egg length FBcv:0000135 80% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS 80-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000136 80-90% egg length FBcv:0000136 80-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 90% of egg length from the posterior tip of the egg or pre-gastrula embryo. spatial_qualifier FBcv:0000137 90% egg length FBcv:0000137 90% of egg length from the posterior tip of the egg or pre-gastrula embryo. FBC:DOS FBcv:0000138 true 90-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBcv:0000138 spatial_qualifier 90-100% egg length FBcv:0000139 90-100% egg length FBcv:0000139 90-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS A record of an analysis carried out by FlyBase that has not been formally published. pub_type FBcv:0000140 FlyBase analysis FBcv:0000140 A record of an analysis carried out by FlyBase that has not been formally published. FBC:SM Expression pattern which varies in intensity following a gradient in a specific axis. spatial_qualifier FBcv:0000141 gradient FBcv:0000141 Expression pattern which varies in intensity following a gradient in a specific axis. FBC:MMC Expression pattern which varies in intensity following a gradient in the anterior-posterior axis. spatial_qualifier FBcv:0000142 anterior posterior gradient FBcv:0000142 Expression pattern which varies in intensity following a gradient in the anterior-posterior axis. FBC:MMC Expression pattern which varies in intensity following a gradient in the dorsal-ventral axis. spatial_qualifier FBcv:0000143 dorsal ventral gradient FBcv:0000143 Expression pattern which varies in intensity following a gradient in the dorsal-ventral axis. FBC:MMC FlyBase miscellaneous CV FBcv:0000144 obsolete maternal pattern true FBcv:0000144 Restricted to stripes in some specified type. spatial_qualifier FBcv:0000145 striped FBcv:0000145 Restricted to stripes in some specified type. FBC:DS Sequence change caused by the cleavage of a 19-24 bp palindromic DNA site by the I-CreI endonuclease. change induced by I-CreI endonuclease cleavage origin_of_mutation FBcv:0000146 I-CreI FBcv:0000146 Sequence change caused by the cleavage of a 19-24 bp palindromic DNA site by the I-CreI endonuclease. UniProt:P05725 Expression in even, but not odd numbered segment of the blastoderm. embryonic_pattern_qualifier FBcv:0000147 even pair rule expression pattern FBcv:0000147 Expression in even, but not odd numbered segment of the blastoderm. FBC:DOS Expression in odd, but not even numbered segments of the blastoderm. embryonic_pattern_qualifier FBcv:0000148 odd pair rule expression pattern FBcv:0000148 Expression in odd, but not even numbered segments of the blastoderm. FBC:DOS A list of species found in a specified area. pub_type FBcv:0000149 species list FBcv:0000149 A list of species found in a specified area. FBC:SM Restricted to a segmentally repeated pattern with some specified type. spatial_qualifier FBcv:0000150 segmentally repeated FBcv:0000150 Restricted to a segmentally repeated pattern with some specified type. FBC:DOS pub_type FBcv:0000151 This term was obsoleted because there because there were no instances of its use to classify any artefact in FlyBase. obsolete archive true FBcv:0000151 A stock with one or more chromosomes (balancers) that are used primarily for their ability to preserve a stock genotype without selection. FlyBase miscellaneous CV FBcv:0000152 Consider - FBsv:0001001. obsolete balancer stock true FBcv:0000152 A stock with one or more chromosomes (balancers) that are used primarily for their ability to preserve a stock genotype without selection. FBC:KM A phenotypic effect which is expressed in and limited to cells of the mutant genetic constitution under investigation is said to be cell autonomous. genotype_to_phenotype_relation FBcv:0000153 cell autonomous FBcv:0000153 A phenotypic effect which is expressed in and limited to cells of the mutant genetic constitution under investigation is said to be cell autonomous. FlyBase:FBrf0002379 A phenotypic effect which is not expressed in/limited to cells of the mutant genetic constitution under investigation is said to be cell non-autonomous. genotype_to_phenotype_relation FBcv:0000154 cell non-autonomous FBcv:0000154 A phenotypic effect which is not expressed in/limited to cells of the mutant genetic constitution under investigation is said to be cell non-autonomous. FlyBase:FBrf0002379 Chromosome that carries inversions and visible mutations, and which can be used to identify the genotype of an individual. FlyBase miscellaneous CV FBcv:0000155 single balancer FBcv:0000155 Chromosome that carries inversions and visible mutations, and which can be used to identify the genotype of an individual. FlyBase:FBrf0089469 FlyBase:FBrf0202435 FlyBase miscellaneous CV FBcv:0000156 obsolete pair of homologous balancers true FBcv:0000156 FlyBase miscellaneous CV FBcv:0000157 obsolete recessive lethal balancer true FBcv:0000157 FlyBase miscellaneous CV FBcv:0000158 Consider - FBsv:0001006. obsolete balancer for chromosome 1 true FBcv:0000158 FlyBase miscellaneous CV FBcv:0000159 Consider - FBsv:0001007. obsolete balancer for chromosome 2 true FBcv:0000159 FlyBase miscellaneous CV FBcv:0000160 Consider - FBsv:0001008. obsolete balancer for chromosome 3 true FBcv:0000160 A phenotypic attribute is described as showing a maternal effect when the phenotype of an individual is a manifestation of the genotype of the mother, rather than the genotype of the individual. genotype_to_phenotype_relation FBcv:0000161 maternal effect FBcv:0000161 A phenotypic attribute is described as showing a maternal effect when the phenotype of an individual is a manifestation of the genotype of the mother, rather than the genotype of the individual. ISBN:978-0-7167-3520-5 A phenotypic attribute is described as showing a non-rescuable maternal effect (strict maternal effect) when the introduction of a wild-type copy of the responsible mutation from the father has no ameliorating effect on the maternal effect mutant phenotype. genotype_to_phenotype_relation FBcv:0000162 non-rescuable maternal effect FBcv:0000162 A phenotypic attribute is described as showing a non-rescuable maternal effect (strict maternal effect) when the introduction of a wild-type copy of the responsible mutation from the father has no ameliorating effect on the maternal effect mutant phenotype. FlyBase:FBrf0049894 A phenotypic attribute is described as showing a rescuable maternal effect when the introduction of a wild-type copy of the responsible mutation from the father ameliorates the maternal effect mutant phenotype. genotype_to_phenotype_relation FBcv:0000163 rescuable maternal effect FBcv:0000163 A phenotypic attribute is described as showing a rescuable maternal effect when the introduction of a wild-type copy of the responsible mutation from the father ameliorates the maternal effect mutant phenotype. FlyBase:FBrf0049894 A phenotypic attribute is described as showing a paternal effect when the phenotype of an individual is a manifestation of the genotype of the father, rather than the genotype of the individual. genotype_to_phenotype_relation FBcv:0000164 paternal effect FBcv:0000164 A phenotypic attribute is described as showing a paternal effect when the phenotype of an individual is a manifestation of the genotype of the father, rather than the genotype of the individual. FlyBase:FBrf0102738 FlyBase miscellaneous CV FBcv:0000165 obsolete pair of balancers for chromosome 2 true FBcv:0000165 Qualifier that describes an observed expression pattern. expression_qualifier FBcv:0000166 morphological qualifier FBcv:0000166 Qualifier that describes an observed expression pattern. FBC:MMC Weak expression. expression_qualifier FBcv:0000167 faint FBcv:0000167 Weak expression. FBC:MMC Expression pattern that resembles small grains or particles. PATO:0001759 expression_qualifier FBcv:0000168 granular FBcv:0000168 Expression pattern that resembles small grains or particles. FBC:MMC Strong expression. PATO:0000049 expression_qualifier FBcv:0000169 intense FBcv:0000169 Strong expression. FBC:MMC Expression pattern that resembles small dots. PATO:0001512 expression_qualifier FBcv:0000170 punctate FBcv:0000170 Expression pattern that resembles small dots. FBC:MMC Expression pattern that is constant throughout the assayed anatomical entity. PATO:0000438 expression_qualifier FBcv:0000171 uniform FBcv:0000171 Expression pattern that is constant throughout the assayed anatomical entity. FBC:MMC Expression pattern that changes throughout the assayed anatomical entity. PATO:0001227 expression_qualifier FBcv:0000172 variable FBcv:0000172 Expression pattern that changes throughout the assayed anatomical entity. FBC:MMC FlyBase miscellaneous CV FBcv:0000173 obsolete pair of balancers for chromosome 3 true FBcv:0000173 FlyBase miscellaneous CV FBcv:0000174 Consider - FBsv:0001012. obsolete dominant male sterile balancer true FBcv:0000174 FlyBase miscellaneous CV FBcv:0000175 Consider - FBsv:0001012. obsolete dominant female sterile balancer true FBcv:0000175 temporal_qualifier FBcv:0000176 temporal qualifier FBcv:0000176 FlyBase miscellaneous CV FBcv:0000177 obsolete dominant female sterile balancer for chromosome 2 true FBcv:0000177 temporal_qualifier FBcv:0000178 This term was obsoleted because a term from the developmental ontology (FBdv) should be used instead [FBC:MMC]. mc161027 obsolete early true FBcv:0000178 FlyBase miscellaneous CV FBcv:0000179 obsolete dominant female sterile balancer for chromosome 3 true FBcv:0000179 FlyBase miscellaneous CV FBcv:0000180 obsolete dominant male sterile balancer for chromosome 2 true FBcv:0000180 temporal_qualifier FBcv:0000181 This term was obsoleted because a term from the developmental ontology (FBdv) should be used instead [FBC:MMC]. mc161027 obsolete late true FBcv:0000181 temporal_qualifier FBcv:0000182 This term was obsoleted because a term from the developmental ontology (FBdv) should be used instead [FBC:MMC]. mc161027 obsolete mid true FBcv:0000182 FlyBase miscellaneous CV FBcv:0000183 This term has been obsoleted because there are new stage terms that can be used instead [FBC:MMC]. mc160113 obsolete n day true FBcv:0000183 FlyBase miscellaneous CV FBcv:0000184 This term has been obsoleted because there are new stage terms that can be used instead [FBC:MMC]. mc160113 obsolete n hr true FBcv:0000184 FlyBase miscellaneous CV FBcv:0000185 obsolete dominant male sterile balancer for chromosome 3 true FBcv:0000185 FlyBase miscellaneous CV FBcv:0000186 obsolete recessive lethal balancer for chromosome 1 true FBcv:0000186 FlyBase miscellaneous CV FBcv:0000187 obsolete recessive lethal balancer for chromosome 2 true FBcv:0000187 Qualifier that describes the type of publication. FlyBase miscellaneous CV FBcv:0000188 publication descriptor FBcv:0000188 Qualifier that describes the type of publication. FBC:MMC A publicly available document. It includes individual articles, such as research papers and reviews, and collections of articles, such as scientific journals. pub_type FBcv:0000189 publication class FBcv:0000189 A publicly available document. It includes individual articles, such as research papers and reviews, and collections of articles, such as scientific journals. FBC:DOS FBC:SM An individual abstract of a presentation at a meeting, congress, conference, symposium, colloquium, seminar, workshop, round table, or other professional gathering. MeSH:D016416 Meeting Abstracts pub_type FBcv:0000190 abstract FBcv:0000190 An individual abstract of a presentation at a meeting, congress, conference, symposium, colloquium, seminar, workshop, round table, or other professional gathering. MeSH:D016416 Meeting Abstracts MeSH:D016416 pub_type FBcv:0000191 This term was obsoleted because it only ever used to annotate a couple of publications. obsolete advertisement true FBcv:0000191 A work consisting of a self-described account. MeSH:D020493 pub_type FBcv:0000192 autobiography FBcv:0000192 A work consisting of a self-described account. MeSH:D020493 A work consisting of a list of books, articles, documents, publications, and other items, usually on a single subject or related subjects. MeSH:D016417 Bibliography pub_type FBcv:0000193 bibliographic list FBcv:0000193 A work consisting of a list of books, articles, documents, publications, and other items, usually on a single subject or related subjects. MeSH:D016417 Bibliography MeSH:D016417 A work consisting of an account of the events, works, and achievements, personal and professional, during a person's life. This class includes articles on the activities and accomplishments of living persons as well as the presentation of an obituary. MeSH:D019215 pub_type FBcv:0000194 biography FBcv:0000194 A work consisting of an account of the events, works, and achievements, personal and professional, during a person's life. This class includes articles on the activities and accomplishments of living persons as well as the presentation of an obituary. MeSH:D019215 A publication on a single subject or related subjects that is complete in itself, whether constructed of chapters, sections, or parts, and that is not issued on a regular, ongoing basis. Every chapter is written by the same author or authors of the publication. pub_type FBcv:0000195 For books (in the common sense of the term) that have different authors for each chapter, please use 'edited book'. book FBcv:0000195 A publication on a single subject or related subjects that is complete in itself, whether constructed of chapters, sections, or parts, and that is not issued on a regular, ongoing basis. Every chapter is written by the same author or authors of the publication. FBC:SM pub_type FBcv:0000196 This term was obsoleted because it was little used in curation. The formerly associated publications have mainly been annotated with other, more appropriate publication classes. obsolete booklet true FBcv:0000196 A work consisting of a critical analysis of one or more books or other monographic works. MeSH:D022921 Book Reviews pub_type FBcv:0000197 book review FBcv:0000197 A work consisting of a critical analysis of one or more books or other monographic works. MeSH:D022921 Book Reviews MeSH:D022921 pub_type CD-ROM FBcv:0000198 obsolete computer file true FBcv:0000198 The published records of the papers delivered at or issued on the occasion of individual congresses, symposia, and meetings; abstracts of papers delivered at such congresses; reports of the officers and delegates of such congresses; combinations of the foregoing; or proceedings of the conference of a society if they are not limited to matters of internal organization. MeSH:D016423 Congresses conference proceedings meeting report pub_type FBcv:0000199 The definition is taken straight from the MeSH term Congresses, which PubMed uses to annotate both meeting reports written by attendees and conference abstract books. This term should therefore be used to index both of these two rather different artefacts. conference report FBcv:0000199 The published records of the papers delivered at or issued on the occasion of individual congresses, symposia, and meetings; abstracts of papers delivered at such congresses; reports of the officers and delegates of such congresses; combinations of the foregoing; or proceedings of the conference of a society if they are not limited to matters of internal organization. MeSH:D016423 Congresses MeSH:D016423 pub_type FBcv:0000200 This term was obsoleted because it was little used. All publications associated with it have been re-annotated with other publication classes. obsolete demonstration true FBcv:0000200 A record of a DNA or RNA sequence in some standard format, such as GenBank or EMBL or DDBJ. pub_type FBcv:0000201 DNA/RNA sequence record FBcv:0000201 A record of a DNA or RNA sequence in some standard format, such as GenBank or EMBL or DDBJ. FBC:DOS FBC:SM A record of a protein sequence in some standard format, such as UniProtKB. pub_type FBcv:0000202 protein sequence record FBcv:0000202 A record of a protein sequence in some standard format, such as UniProtKB. FBC:SM A work consisting of an acknowledgement of an error, issued by a publisher, editor, or author. MeSH:D016425 Corrigendum Published Erratum correction pub_type FBcv:0000203 erratum FBcv:0000203 A work consisting of an acknowledgement of an error, issued by a publisher, editor, or author. MeSH:D016425 Corrigendum MeSH:D016425 Published Erratum MeSH:D016425 A film or video that is factual, documentary or instructional in character. video pub_type FBcv:0000204 film FBcv:0000204 A film or video that is factual, documentary or instructional in character. FBC:SM MeSH:D019499 MeSH:D019514 A work consisting of a conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer. MeSH:D017203 pub_type FBcv:0000205 interview FBcv:0000205 A work consisting of a conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer. MeSH:D017203 pub_type FBcv:0000206 This term was obsoleted because it only ever used to annotate one, unarchived publication. obsolete jigsaw puzzle true FBcv:0000206 A work consisting of written or printed communication between individuals or between persons and representatives of corporate bodies. The correspondence may be personal or professional. MeSH:D016422 pub_type FBcv:0000207 In medical and other scientific publications the letter is usually from one or more authors to the editor of the journal or book publishing the item being commented upon or discussed. letter FBcv:0000207 A work consisting of written or printed communication between individuals or between persons and representatives of corporate bodies. The correspondence may be personal or professional. MeSH:D016422 pub_type FBcv:0000208 This term was obsoleted because it had only been used once in FlyBase, and this was for an artefact that is not present in a FlyBase associated archive. The associated record in FlyBase CHADO has been obsoleted. obsolete microscope slides true FBcv:0000208 A work consisting of an announcement or statement of recent or current events of new data and matters of interest in the field of medicine or science, published in a scientific journal. MeSH:D016433 pub_type FBcv:0000209 news article FBcv:0000209 A work consisting of an announcement or statement of recent or current events of new data and matters of interest in the field of medicine or science, published in a scientific journal. FBC:SM MeSH:D016433 A work consisting of a critical or explanatory note written to discuss, support, or dispute an article or other presentation previously published. MeSH:D016420 Comment pub_type FBcv:0000210 note FBcv:0000210 A work consisting of a critical or explanatory note written to discuss, support, or dispute an article or other presentation previously published. MeSH:D016420 Comment MeSH:D016420 A published announcement of a death accompanied by a short biography of the deceased. pub_type FBcv:0000211 obituary FBcv:0000211 A published announcement of a death accompanied by a short biography of the deceased. FBC:SM An article reporting original research, published in a peer-reviewed journal. Journal article MeSH:D016428 pub_type FBcv:0000212 Note that this is a much more specific class than that referred to by MeSH Journal article (D016428). paper FBcv:0000212 An article reporting original research, published in a peer-reviewed journal. FBC:SM Journal article MeSH:D016428 A work consisting of documents granted by a government giving exclusive rights to an inventor or assignee to manufacture, use, or sell an invention for a certain number of years. MeSH:D020490 pub_type FBcv:0000213 patent FBcv:0000213 A work consisting of documents granted by a government giving exclusive rights to an inventor or assignee to manufacture, use, or sell an invention for a certain number of years. MeSH:D020490 A work that has not been formally published and that consists of observations or data submitted by a researcher or group of researchers directly to FlyBase. pub_type FBcv:0000214 personal communication to FlyBase FBcv:0000214 A work that has not been formally published and that consists of observations or data submitted by a researcher or group of researchers directly to FlyBase. FBC:DOS FBC:SM A literary or oral work expressing meaning via symbolism and following formal or informal patterns. MeSH:D055821 poetry pub_type FBcv:0000215 poem FBcv:0000215 A literary or oral work expressing meaning via symbolism and following formal or informal patterns. MeSH:D055821 poetry MeSH:D055821 A work consisting of a single or multi-sheet notice made to attract attention to events, activities, causes, goods, or services. It is for posting, usually in a public place and is chiefly pictorial. It is intended to make an immediate impression from a distance. MeSH:D019519 pub_type FBcv:0000216 The class does not encompass poster presentations at conferences and meetings. poster FBcv:0000216 A work consisting of a single or multi-sheet notice made to attract attention to events, activities, causes, goods, or services. It is for posting, usually in a public place and is chiefly pictorial. It is intended to make an immediate impression from a distance. MeSH:D019519 A written or recorded communication directed at members of the news media for the purpose of announcing something ostensibly newsworthy. pub_type FBcv:0000217 press release FBcv:0000217 A written or recorded communication directed at members of the news media for the purpose of announcing something ostensibly newsworthy. http://en.wikipedia.org/w/index.php?title=Press_release&oldid=482495713 pub_type FBcv:0000218 This term has been obsoleted because it was little used in curation and the artefacts annotated with it are not present in any FlyBase associated archive. Records annotated with this term have been obsoleted in the FlyBase CHADO database. obsolete recording true FBcv:0000218 A work consisting of a statement issued by one or more authors of an article or a book, withdrawing or disavowing acknowledgement of their participation in performing research or writing the results of their study. MeSH:D016440 Retraction of Publication pub_type FBcv:0000219 retraction FBcv:0000219 A work consisting of a statement issued by one or more authors of an article or a book, withdrawing or disavowing acknowledgement of their participation in performing research or writing the results of their study. MeSH:D016440 Retraction of Publication MeSH:D016440 An article or book published after examination of published material on a subject. MeSH:D016454 pub_type FBcv:0000220 The reviews most often desired are reviews of the current literature, but a review of historical literature is also within the scope of this publication type. review FBcv:0000220 An article or book published after examination of published material on a subject. MeSH:D016454 pub_type FBcv:0000221 This term has been obsoleted because it was little used in curation and the artefacts annotated with it are not present in any FlyBase associated archive. obsolete slides true FBcv:0000221 A mildly satirical mockery or parody of a conventional publication type. MeSH:D020480 pub_type FBcv:0000222 spoof FBcv:0000222 A mildly satirical mockery or parody of a conventional publication type. FBC:SM A list of Drosophila stocks kept by a specified stock center or research group. pub_type FBcv:0000223 stock list FBcv:0000223 A list of Drosophila stocks kept by a specified stock center or research group. FBC:SM Supporting content or information, such as animation, datasets, multimedia files, video, movies, audio files, text files, or software, which is submitted for publication in an online journal or an online edition of a journal. This information may be referenced in the text of the article with a link to the supplementary data provided. MeSH:D058537 Electronic Supplementary Materials additional files supplementary information supporting information pub_type FBcv:0000224 supplementary material FBcv:0000224 Supporting content or information, such as animation, datasets, multimedia files, video, movies, audio files, text files, or software, which is submitted for publication in an online journal or an online edition of a journal. This information may be referenced in the text of the article with a link to the supplementary data provided. MeSH:D058537 Electronic Supplementary Materials MeSH:D058537 pub_type FBcv:0000225 This term was obsoleted because it had been used only once in ~20 years of curation. obsolete T-shirt true FBcv:0000225 A diagram that is designed to be touched, rather than looked at. These are generally made for use by blind or visually impaired people. pub_type FBcv:0000226 obsolete tactile diagram true FBcv:0000226 A diagram that is designed to be touched, rather than looked at. These are generally made for use by blind or visually impaired people. FBC:DOS An article describing exercises or practicals suitable for teaching. pub_type FBcv:0000227 teaching note FBcv:0000227 An article describing exercises or practicals suitable for teaching. FBC:SM A work consisting of a formal presentation made usually to fulfill requirements for an academic degree. MeSH:D019478 Academic Dissertations pub_type FBcv:0000228 thesis FBcv:0000228 A work consisting of a formal presentation made usually to fulfill requirements for an academic degree. MeSH:D019478 Academic Dissertations MeSH:D019478 A systematic effort to annotate gene models on a sequenced Drosophila genome, such as those conducted for D. melanogaster at the Celera Jamboree. Annotations may be performed manually or automatically. pub_type automatic genome annotation FBcv:0000229 Note that the name of this publication type will change to simply 'genome annotation', but this change has been delayed pending required work on the database. curated genome annotation FBcv:0000229 A systematic effort to annotate gene models on a sequenced Drosophila genome, such as those conducted for D. melanogaster at the Celera Jamboree. Annotations may be performed manually or automatically. FBC:SM pub_type FBcv:0000230 This term was obsoleted because it was hardly ever used. Please use FBcv:0000229 instead. obsolete automatic genome annotation true FBcv:0000230 A work consisting of a set of statements, directions, or principles presenting current or future rules or policy. Guideline MeSH:D016431 pub_type FBcv:0000231 white paper FBcv:0000231 A work consisting of a set of statements, directions, or principles presenting current or future rules or policy. FBC:SM MeSH:D016431 Guideline MeSH:D016431 FlyBase miscellaneous CV FBcv:0000232 obsolete recessive lethal balancer for chromosome 3 true FBcv:0000232 A work that has not been formally published. MeSH:D022902 Unpublished Works pub_type privately distributed report FBcv:0000233 unpublished FBcv:0000233 A work that has not been formally published. MeSH:D022902 Unpublished Works MeSH:D022902 Qualifier that describes the language of the publication. language FBcv:0000234 publication language FBcv:0000234 Qualifier that describes the language of the publication. FBC:MMC Publication in the Afrikaans language. language FBcv:0000235 Afrikaans FBcv:0000235 Publication in the Afrikaans language. FBC:MMC Publication in the Arabic language. language FBcv:0000236 Arabic FBcv:0000236 Publication in the Arabic language. FBC:MMC Publication in the Armenian language. language FBcv:0000237 Armenian FBcv:0000237 Publication in the Armenian language. FBC:MMC Publication in the Belarussian language. language Belarusian FBcv:0000238 Belarussian FBcv:0000238 Publication in the Belarussian language. FBC:MMC Publication in the Bulgarian language. language FBcv:0000239 Bulgarian FBcv:0000239 Publication in the Bulgarian language. FBC:MMC Publication in the Catalan language. language FBcv:0000240 Catalan FBcv:0000240 Publication in the Catalan language. FBC:MMC Publication in the Chinese language. language FBcv:0000241 Chinese FBcv:0000241 Publication in the Chinese language. FBC:MMC Publication in the Cumbrian language. language FBcv:0000242 Cumbrian FBcv:0000242 Publication in the Cumbrian language. FBC:MMC Publication in the Czech language. language FBcv:0000243 Czech FBcv:0000243 Publication in the Czech language. FBC:MMC Publication in the Danish language. language FBcv:0000244 Danish FBcv:0000244 Publication in the Danish language. FBC:MMC Publication in the Dutch language. language FBcv:0000245 Dutch FBcv:0000245 Publication in the Dutch language. FBC:MMC Publication in the English language. language FBcv:0000246 English FBcv:0000246 Publication in the English language. FBC:MMC Publication in the Estonian language. language FBcv:0000247 Estonian FBcv:0000247 Publication in the Estonian language. FBC:MMC Publication in the Faroese language. language FBcv:0000248 Faroese FBcv:0000248 Publication in the Faroese language. FBC:MMC Publication in the Farsi language. language FBcv:0000249 Farsi FBcv:0000249 Publication in the Farsi language. FBC:MMC Publication in the Finnish language. language FBcv:0000250 Finnish FBcv:0000250 Publication in the Finnish language. FBC:MMC Publication in the Flemish language. language FBcv:0000251 Flemish FBcv:0000251 Publication in the Flemish language. FBC:MMC Publication in the French language. language FBcv:0000252 French FBcv:0000252 Publication in the French language. FBC:MMC Publication in the German language. language FBcv:0000253 German FBcv:0000253 Publication in the German language. FBC:MMC Publication in the Greek language. language FBcv:0000254 Greek FBcv:0000254 Publication in the Greek language. FBC:MMC Publication in the Hebrew language. language FBcv:0000255 Hebrew FBcv:0000255 Publication in the Hebrew language. FBC:MMC Publication in the Hungarian language. language FBcv:0000256 Hungarian FBcv:0000256 Publication in the Hungarian language. FBC:MMC Publication in the Icelandic language. language FBcv:0000257 Icelandic FBcv:0000257 Publication in the Icelandic language. FBC:MMC Publication in the Indonesian language. language FBcv:0000258 Indonesian FBcv:0000258 Publication in the Indonesian language. FBC:MMC Publication in the Italian language. language FBcv:0000259 Italian FBcv:0000259 Publication in the Italian language. FBC:MMC Publication in the Japanese language. language FBcv:0000260 Japanese FBcv:0000260 Publication in the Japanese language. FBC:MMC Publication in the Jugoslavian language. language FBcv:0000261 Jugoslavian FBcv:0000261 Publication in the Jugoslavian language. FBC:MMC Publication in the Korean language. language FBcv:0000262 Korean FBcv:0000262 Publication in the Korean language. FBC:MMC Publication in the Latin language. language FBcv:0000263 Latin FBcv:0000263 Publication in the Latin language. FBC:MMC Publication in the Latvian language. language FBcv:0000264 Latvian FBcv:0000264 Publication in the Latvian language. FBC:MMC Publication in the Lithuanian language. language FBcv:0000265 Lithuanian FBcv:0000265 Publication in the Lithuanian language. FBC:MMC Publication in the Malay language. language FBcv:0000266 Malay FBcv:0000266 Publication in the Malay language. FBC:MMC Publication in the Malayalam language. language FBcv:0000267 Malayalam FBcv:0000267 Publication in the Malayalam language. FBC:MMC Publication in the Norwegian language. language FBcv:0000268 Norwegian FBcv:0000268 Publication in the Norwegian language. FBC:MMC Publication in the Polish language. language FBcv:0000269 Polish FBcv:0000269 Publication in the Polish language. FBC:MMC Publication in the Portuguese language. language FBcv:0000270 Portuguese FBcv:0000270 Publication in the Portuguese language. FBC:MMC Publication in the Serbo-Croat (Roman) language. language FBcv:0000271 Serbo-Croat(Roman) FBcv:0000271 Publication in the Serbo-Croat (Roman) language. FBC:MMC Publication in the Roman language. language FBcv:0000272 Romanian FBcv:0000272 Publication in the Roman language. FBC:MMC Publication in the Russian language. language FBcv:0000273 Russian FBcv:0000273 Publication in the Russian language. FBC:MMC Publication in the Serbo-Croat language. language FBcv:0000274 Serbo-Croat FBcv:0000274 Publication in the Serbo-Croat language. FBC:MMC Publication in the Slovak language. language FBcv:0000275 Slovak FBcv:0000275 Publication in the Slovak language. FBC:MMC Publication in the Slovenian language. language FBcv:0000276 Slovenian FBcv:0000276 Publication in the Slovenian language. FBC:MMC Publication in the Spanish language. language FBcv:0000277 Spanish FBcv:0000277 Publication in the Spanish language. FBC:MMC Publication in the Swedish language. language FBcv:0000278 Swedish FBcv:0000278 Publication in the Swedish language. FBC:MMC Publication in the Turkish language. language FBcv:0000279 Turkish FBcv:0000279 Publication in the Turkish language. FBC:MMC Publication in the Ukrainian language. language FBcv:0000280 Ukrainian FBcv:0000280 Publication in the Ukrainian language. FBC:MMC Publication in the Yiddish language. language FBcv:0000281 Yiddish FBcv:0000281 Publication in the Yiddish language. FBC:MMC Rank that describes the usefulness of mutants according to their phenotype. scorability FBcv:0000282 mutant scorability rank FBcv:0000282 Rank that describes the usefulness of mutants according to their phenotype. FBC:MMC The RK1 rank describes mutants that are easily scored. scorability FBcv:0000283 RK1 FBcv:0000283 The RK1 rank describes mutants that are easily scored. FlyBase:FBrf0066905 The RK2 rank describes mutants that are usable but less convenient. scorability FBcv:0000284 RK2 FBcv:0000284 The RK2 rank describes mutants that are usable but less convenient. FlyBase:FBrf0066905 The RK3 rank describes mutants that are of limited usefulness. scorability FBcv:0000285 RK3 FBcv:0000285 The RK3 rank describes mutants that are of limited usefulness. FlyBase:FBrf0066905 Term that describes the type of allele. allele morphy class allele_class FBcv:0000286 allele class FBcv:0000286 Term that describes the type of allele. FBC:MMC An allele that either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type. allele_class FBcv:0000287 Loss of function alleles are generally, but not exclusively, recessive. At haplo-insufficient loci (loci that require two copies for normal function), loss of function alleles can be dominant. loss of function allele FBcv:0000287 An allele that either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type. FlyBase:FBrf0049147 An allele inferred to completely lack function from the observation that addition of extra copies in the genome has no effect on the phenotype. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy). allele_class FBcv:0000288 amorphic allele - genetic evidence FBcv:0000288 An allele inferred to completely lack function from the observation that addition of extra copies in the genome has no effect on the phenotype. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy). FlyBase:FBrf0002371 FlyBase:FBrf0049147 Allele inferred to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity from the observation that extra copies in the genome decrease the expressivity and/or penetrance of the phenotype. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype than the allele in trans to a deletion of the gene (1 copy)). allele_class FBcv:0000289 hypomorphic allele - genetic evidence FBcv:0000289 Allele inferred to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity from the observation that extra copies in the genome decrease the expressivity and/or penetrance of the phenotype. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype than the allele in trans to a deletion of the gene (1 copy)). FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type. allele_class FBcv:0000290 Gain of function alleles are generally dominant. But not all dominant alleles are gain of function alleles. gain of function allele FBcv:0000290 An allele that either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type. FlyBase:FBrf0049147 An allele that is inferred to make a gene product with a novel function or expression pattern compared to wild-type based on the evidence that the phenotype is unaffected by extra or fewer doses of the wild-type gene. allele_class FBcv:0000291 neomorphic allele - genetic evidence FBcv:0000291 An allele that is inferred to make a gene product with a novel function or expression pattern compared to wild-type based on the evidence that the phenotype is unaffected by extra or fewer doses of the wild-type gene. FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that is inferred to make a gene product that is antagonistic to the wild-type gene product from the observations that extra copies of the wild-type allele reduce the expressivity and/or penetrance of the phenotype. So, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. This test is similar to that used for hypomorphic alleles. An antimorph can be distinguished from a dominant hypermorph as only the former can be reverted to wild-type by deletion of the mutant allele. allele_class FBcv:0000292 antimorphic allele - genetic evidence FBcv:0000292 An allele that is inferred to make a gene product that is antagonistic to the wild-type gene product from the observations that extra copies of the wild-type allele reduce the expressivity and/or penetrance of the phenotype. So, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. This test is similar to that used for hypomorphic alleles. An antimorph can be distinguished from a dominant hypermorph as only the former can be reverted to wild-type by deletion of the mutant allele. FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred to make either increased amounts of a normal gene product or a gene product with normal function but increased activity compared to wild-type from the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype. Most commonly this evidence takes the form of experiments showing that homozygotes (2 copies) have a stronger phenotype than transheterozygotes to a deletion of the gene (1 copy). allele_class FBcv:0000293 hypermorphic allele - genetic evidence FBcv:0000293 An allele inferred to make either increased amounts of a normal gene product or a gene product with normal function but increased activity compared to wild-type from the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype. Most commonly this evidence takes the form of experiments showing that homozygotes (2 copies) have a stronger phenotype than transheterozygotes to a deletion of the gene (1 copy). FlyBase:FBrf0002371 FlyBase:FBrf0049147 Allele that corresponds to the wild-type one. allele_class FBcv:0000294 wild-type allele FBcv:0000294 Allele that corresponds to the wild-type one. FBC:MMC Wild-type allele that can be distinguished from others. allele_class FBcv:0000295 wild-type generic FBcv:0000295 Wild-type allele that can be distinguished from others. FBC:MMC Wild-type allele that can only be distinguished from another one under special conditions. allele_class FBcv:0000296 isoallele FBcv:0000296 Wild-type allele that can only be distinguished from another one under special conditions. FlyBase:FBrf0202435 FlyBase miscellaneous CV FBcv:0000297 obsolete extracted wild-type chromosome 1 true FBcv:0000297 A phenotypic attribute is described as recessive when it is manifest only in individuals homozygous or hemizygous for the allele that causes that phenotype. dominance_qualifier FBcv:0000298 recessive FBcv:0000298 A phenotypic attribute is described as recessive when it is manifest only in individuals homozygous or hemizygous for the allele that causes that phenotype. ISBN:978-0-8053-0316-2 A phenotypic attribute is described as dominant when it is manifest in individuals heterozygous for the allele that causes that phenotype. dominance_qualifier FBcv:0000299 dominant FBcv:0000299 A phenotypic attribute is described as dominant when it is manifest in individuals heterozygous for the allele that causes that phenotype. ISBN:978-0-8053-0316-2 A phenotypic attribute is described as codominant when it is manifest in individuals carrying the allele that causes that phenotype, irrespective of the homologous allele. dominance_qualifier FBcv:0000300 codominant FBcv:0000300 A phenotypic attribute is described as codominant when it is manifest in individuals carrying the allele that causes that phenotype, irrespective of the homologous allele. ISBN:978-0-8053-0316-2 A phenotypic attribute is described as semidominant when individuals heterozygous for the allele show phenotypes part way between homozygotes for either allele. dominance_qualifier FBcv:0000301 semidominant FBcv:0000301 A phenotypic attribute is described as semidominant when individuals heterozygous for the allele show phenotypes part way between homozygotes for either allele. ISBN:978-0-8053-0316-2 FlyBase miscellaneous CV FBcv:0000302 obsolete extracted wild-type chromosome 2 true FBcv:0000302 FlyBase miscellaneous CV FBcv:0000303 obsolete extracted wild-type chromosome 3 true FBcv:0000303 FlyBase miscellaneous CV FBcv:0000304 obsolete extracted wild-type chromosome 4 true FBcv:0000304 FlyBase miscellaneous CV FBcv:0000305 obsolete extracted wild-type chromosome Y true FBcv:0000305 Expression is limited to one or other sex by virtue of the particular biology of that sex, rather than the sex-linkage of the genes underlying the attribute. sex_qualifier FBcv:0000306 May be used to qualify expression of phenotypes or of genes, transgenes etc. sex limited FBcv:0000306 Expression is limited to one or other sex by virtue of the particular biology of that sex, rather than the sex-linkage of the genes underlying the attribute. FlyBase:FBrf0075559 Expression is limited to males by virtue of the particular biology of males, rather than the sex-linkage of the gene(s) involved. sex_qualifier FBcv:0000307 May be used to qualify expression of phenotypes or of genes, transgenes etc. male limited FBcv:0000307 Expression is limited to males by virtue of the particular biology of males, rather than the sex-linkage of the gene(s) involved. FlyBase:FBrf0075559 Expression is limited to females by virtue of the particular biology of females, rather than the sex-linkage of the gene(s) involved. sex_qualifier FBcv:0000308 May be used to qualify expression of phenotypes or of genes, transgenes etc. female limited FBcv:0000308 Expression is limited to females by virtue of the particular biology of females, rather than the sex-linkage of the gene(s) involved. FlyBase:FBrf0075559 Phenotype expressed only under specific environmental conditions that do not induce the same defect in wild-type animals. environmental_qualifier conditional qualifier FBcv:0000309 conditional FBcv:0000309 Phenotype expressed only under specific environmental conditions that do not induce the same defect in wild-type animals. FBC:DOS Phenotype only expressed in some subset of the temperature range within which wild-type animals are viable. environmental_qualifier FBcv:0000310 temperature conditional FBcv:0000310 Phenotype only expressed in some subset of the temperature range within which wild-type animals are viable. FBC:DOS Phenotype only expressed at high temperatures. conditional - heat sensitive conditional ts hs environmental_qualifier FBcv:0000311 heat sensitive FBcv:0000311 Phenotype only expressed at high temperatures. FBC:DOS Phenotype only expressed at low temperatures. conditional - cold sensitive conditional cs cs environmental_qualifier FBcv:0000312 cold sensitive FBcv:0000312 Phenotype only expressed at low temperatures. FBC:DOS Phenotype expressed only in the presence of some specific drug (CHEBI:23888) whose presence does not induce the same defect in wild-type animals. environmental_qualifier FBcv:0000313 drug conditional FBcv:0000313 Phenotype expressed only in the presence of some specific drug (CHEBI:23888) whose presence does not induce the same defect in wild-type animals. FBC:DOS Phenotype expressed only in the presence of RU486 (CHEBI:50692), also known as mifepristone. conditional RU486 conditional mifepristone environmental_qualifier FBcv:0000314 RU486 conditional FBcv:0000314 Phenotype expressed only in the presence of RU486 (CHEBI:50692), also known as mifepristone. FBC:DOS Phenotype expressed only in the presence of tetracycline (CHEBI:27902). conditional tetracycline environmental_qualifier FBcv:0000315 tetracycline conditional FBcv:0000315 Phenotype expressed only in the presence of tetracycline (CHEBI:27902). FBC:DOS Phenotype that is the partial or full transformation of one or more segments (FBbt:00000003) or segmental appendages from one identity to another. For example, in antennapedia an antenna is partially or fully transformed into a leg. phenotypic_class FBcv:0000316 homeotic FBcv:0000316 Phenotype that is the partial or full transformation of one or more segments (FBbt:00000003) or segmental appendages from one identity to another. For example, in antennapedia an antenna is partially or fully transformed into a leg. FBC:DOS FlyBase miscellaneous CV FBcv:0000317 obsolete isogenic chromosome 1 true FBcv:0000317 FlyBase miscellaneous CV FBcv:0000318 obsolete isogenic chromosome 2 true FBcv:0000318 Expression across a contiguous block of two or more segments of the blastoderm. embryonic_pattern_qualifier FBcv:0000319 gap expression pattern FBcv:0000319 Expression across a contiguous block of two or more segments of the blastoderm. FBC:DOS Expression in the terminal regions of the embryo/larva: the acron, telson and adjacent segments. embryonic_pattern_qualifier terminal FBcv:0000320 terminal expression pattern FBcv:0000320 Expression in the terminal regions of the embryo/larva: the acron, telson and adjacent segments. FBC:DOS FlyBase miscellaneous CV FBcv:0000321 obsolete isogenic chromosome 3 true FBcv:0000321 Expression in alternate segments of the blastoderm. embryonic_pattern_qualifier FBcv:0000322 pair rule expression pattern FBcv:0000322 Expression in alternate segments of the blastoderm. FBC:DOS Qualifier that describes an expression pattern of a segment polarity gene. Expression is observed in a specific location in each segment. embryonic_pattern_qualifier FBcv:0000323 segment polarity expression pattern FBcv:0000323 Qualifier that describes an expression pattern of a segment polarity gene. Expression is observed in a specific location in each segment. FBC:MMC Phenotype that is any abnormality in dorsal/ventral axis specification (GO:0009950). 'dorsal/ventral axis specification' is defined as: 'The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.' dorsal/ventral axis specification defective phenotypic_class dorsal-ventral polarity FBcv:0000324 abnormal dorsal/ventral axis specification FBcv:0000324 Phenotype that is any abnormality in dorsal/ventral axis specification (GO:0009950). 'dorsal/ventral axis specification' is defined as: 'The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.' FBC:DOS GOC:dph GOC:go_curators GOC:tb dorsal-ventral polarity FBC:DOS A phenotype that is an expansion of the developing embryonic nervous system at the expense of developing ventral epidermis. 2011-09-13T02:42:10Z phenotypic_class FBcv:0000325 Typically this is caused by and expansion of the population of neuroblasts at the expense of prospective epidermis, both of which originate in the ventral ectoderm. neurogenic phenotype FBcv:0000325 A phenotype that is an expansion of the developing embryonic nervous system at the expense of developing ventral epidermis. FlyBase:FBrf0040185 FlyBase miscellaneous CV FBcv:0000326 obsolete isogenic chromosome 4 true FBcv:0000326 FlyBase miscellaneous CV FBcv:0000327 obsolete P-element transposase source for transposable element mutagenesis true FBcv:0000327 FlyBase miscellaneous CV FBcv:0000328 obsolete hobo transposase source for transposable element mutagenesis true FBcv:0000328 FlyBase miscellaneous CV FBcv:0000329 obsolete piggyBac transposase source for transposable element mutagenesis true FBcv:0000329 FlyBase miscellaneous CV FBcv:0000330 obsolete minos transposase source for transposable element mutagenesis true FBcv:0000330 temporal_qualifier FBcv:0000331 This term has been obsoleted because there are new terms to replace it [FBC:MMC]. mc161027 obsolete polyphasic true FBcv:0000331 Qualifier that relates the expression of a phenotype to the sex of the individual. sex qualifier sex_qualifier FBcv:0000332 sex FBcv:0000332 Qualifier that relates the expression of a phenotype to the sex of the individual. FBC:MMC sex qualifier FBC:DOS Expressed in males. sex_qualifier FBcv:0000333 This term has historically been used as a qualifier for expression and phenotype, but its use for phenotype has been deprecated. Its use does not imply expression exclusively in males. male FBcv:0000333 Expressed in males. FBC:DOS Expressed in females. sex_qualifier FBcv:0000334 This term has historically been used as a qualifier for expression and phenotype, but its use for phenotype has been deprecated. Its use does not imply expression exclusively in females. female FBcv:0000334 Expressed in females. FBC:DOS A clone of germline cells that share a genotype. germ-line clone clone_qualifier FBcv:0000335 germline clone FBcv:0000335 A clone of germline cells that share a genotype. FBC:DOS A clone of somatic cells that share a genotype that is different from the genotype of the animal in which it resides and from which it is derived. clone_qualifier FBcv:0000336 somatic clone FBcv:0000336 A clone of somatic cells that share a genotype that is different from the genotype of the animal in which it resides and from which it is derived. FBC:DOS FlyBase miscellaneous CV FBcv:0000337 obsolete P-element ammunition for transposable element mutagenesis true FBcv:0000337 FlyBase miscellaneous CV FBcv:0000338 obsolete hobo ammunition for transposable element mutagenesis true FBcv:0000338 extent FBcv:0000339 DEPRECATION WARNING: This term has been obsoleted as 'fully' is assumed in the absence of use of 'partially'. mc151118 obsolete fully true FBcv:0000339 Incomplete penetrance or expressivity of a phenotype or incomplete suppression of a phenotype. extent FBcv:0000340 Note on usage: This qualifier should not be used in combination with lethal, viable, sterile or fertile. For these cases, terms of the form semi-X should be used instead. partially FBcv:0000340 Incomplete penetrance or expressivity of a phenotype or incomplete suppression of a phenotype. FBC:DOS intensity_qualifier FBcv:0000341 This term has been obsoleted as it should be assumed a phenotype is good, unless it is said otherwise, by using other qualifiers. mc151118 obsolete good true FBcv:0000341 Qualifier that describes a phenotype that has poor penetrance or expressivity. intensity_qualifier FBcv:0000342 poor FBcv:0000342 Qualifier that describes a phenotype that has poor penetrance or expressivity. FBC:MMC Qualifier that describes a phenotype that has reduced penetrance or expressivity when compared to wild-type. intensity_qualifier FBcv:0000343 reduced FBcv:0000343 Qualifier that describes a phenotype that has reduced penetrance or expressivity when compared to wild-type. FBC:MMC Qualifier that describes an electrophoretic migration of a gene product that is slower than the wild-type. PATO:0000304 intensity_qualifier FBcv:0000344 slow FBcv:0000344 Qualifier that describes an electrophoretic migration of a gene product that is slower than the wild-type. FBC:MMC Qualifier that describes an electrophoretic migration of a gene product that is intermediate in speed compared to the wild-type. PATO:0000303 intensity_qualifier FBcv:0000345 fast FBcv:0000345 Qualifier that describes an electrophoretic migration of a gene product that is intermediate in speed compared to the wild-type. FBC:MMC Qualifier that describes a phenotype that is intermediate in speed compared to the wild-type. intensity_qualifier FBcv:0000346 This qualifier can be used to describe an electrophoretic migration of a gene product that is intermediate in speed compared to the wild-type. intermediate FBcv:0000346 Qualifier that describes a phenotype that is intermediate in speed compared to the wild-type. FBC:MMC phenotypic_class FBcv:0000347 phenotypic class FBcv:0000347 The canonical phenotype of a wild-type Drosophilid. phenotypic_class FBcv:0000348 wild-type FBcv:0000348 The canonical phenotype of a wild-type Drosophilid. FBC:DOS A phenotype that is survival to mature adulthood, where mature is defined as after adult stage A3 (FBdv:00006012). phenotypic_class FBcv:0000349 Note, this term should not be used with the qualifier 'partially'. Use semi-viable or semi-lethal instead. viable FBcv:0000349 A phenotype that is survival to mature adulthood, where mature is defined as after adult stage A3 (FBdv:00006012). FBC:DOS A phenotype of a population that is the death of some significant proportion of animals in that population, but less that half, prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). semi-viable phenotypic_class FBcv:0000350 partially lethal - majority live FBcv:0000350 A phenotype of a population that is the death of some significant proportion of animals in that population, but less that half, prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). FBC:DOS A phenotype of a population that is the death of all animals in that population at some stage or stages prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). phenotypic_class FBcv:0000351 Note on usage: lethal is appropriate in cases where escaper adults are very rare. The lethal phase prior to becoming a mature adult may be further specified using children terms which specify stage. lethal FBcv:0000351 A phenotype of a population that is the death of all animals in that population at some stage or stages prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). FBC:DOS FBC:KM A phenotype of a population that is the death of a majority of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). semi-lethal phenotypic_class FBcv:0000352 Stages during which there is significant death prior to mature adulthood can be indicated using one or more stage qualifiers. partially lethal - majority die FBcv:0000352 A phenotype of a population that is the death of a majority of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). FBC:DOS FBC:KM FBC:NB A phenotype that is a failure of mutant cells to survive. phenotypic_class FBcv:0000353 Typically, this phenotype is assayed in clones of cells. cell lethal FBcv:0000353 A phenotype that is a failure of mutant cells to survive. FBC:DOS A post-embryonic, macroscopic, anatomical phenotype. phenotypic_class FBcv:0000354 visible FBcv:0000354 A post-embryonic, macroscopic, anatomical phenotype. FBC:DOS Phenotype that is any abnormality in eye color compared to wild-type. eye color defective eye colour defective phenotypic_class FBcv:0000355 abnormal eye color FBcv:0000355 Phenotype that is any abnormality in eye color compared to wild-type. FBC:DOS A phenotype that is any abnormality in body color compared to wild-type. body color defective body colour defective phenotypic_class FBcv:0000356 abnormal body color FBcv:0000356 A phenotype that is any abnormality in body color compared to wild-type. FBC:DOS A phenotype that is any abnormality in the size of the whole body or some body part compared to wild-type. size defective phenotypic_class FBcv:0000357 abnormal size FBcv:0000357 A phenotype that is any abnormality in the size of the whole body or some body part compared to wild-type. FBC:DOS Phenotype that is a decrease in body size compared to identically raised wild-type controls. reduced body size small body phenotypic_class FBcv:0000358 decreased body size FBcv:0000358 Phenotype that is a decrease in body size compared to identically raised wild-type controls. FBC:DOS Phenotype that is a decrease in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth - there may be fewer cells in an otherwise normal volume of tissue. reduced cell number phenotypic_class FBcv:0000359 decreased cell number FBcv:0000359 Phenotype that is a decrease in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth - there may be fewer cells in an otherwise normal volume of tissue. FBC:DOS Phenotype that is a decrease in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth of a tissue - there may be more cells in an otherwise normal volume of tissue. reduced cell size phenotypic_class FBcv:0000360 Note that defects in cell size are not necessarily the result of defects in cell growth. A change in the rate of cell division in the absence of any change in cell growth rate can result in smaller or larger cells. decreased cell size FBcv:0000360 Phenotype that is a decrease in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth of a tissue - there may be more cells in an otherwise normal volume of tissue. FBC:DOS Phenotype that is an increase in body size compared to identically raised wild-type controls. large body phenotypic_class FBcv:0000361 increased body size FBcv:0000361 Phenotype that is an increase in body size compared to identically raised wild-type controls. FBC:DOS Phenotype that is an increase in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. phenotypic_class FBcv:0000362 This phenotype is not necessarily accompanied by overgrowth of a tissue - there may be more cells in an otherwise normal volume of tissue. It is not necessarily due to an increase in cell growth -it may be the result of an increase in the division rate at normal growth rates. It may not even be due to an increase in the cell division rate - a reduced rate of cell death while the division rate is normal could also achieve it. increased cell number FBcv:0000362 Phenotype that is an increase in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. FBC:DOS Phenotype that is an increase in the size of cells compared to wild-type. phenotypic_class FBcv:0000363 May be due to an increase in the cell growth rate or to a reduced rate of cell division along with a normal rate of cell growth. increased cell size FBcv:0000363 Phenotype that is an increase in the size of cells compared to wild-type. FBC:DOS A phenotype that is the inability to produce fertilized eggs as a result of mating. phenotypic_class FBcv:0000364 The cause of sterility may be physical or behavioral. Note, this term should not be used with the qualifier 'partially'. Use semi-sterile or semi-fertile instead. sterile FBcv:0000364 A phenotype that is the inability to produce fertilized eggs as a result of mating. FBC:AO FBC:CP FBC:DOS A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating to below 50% of wild-type. phenotypic_class FBcv:0000365 semi-sterile FBcv:0000365 A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating to below 50% of wild-type. FBC:AO FBC:CP FBC:DOS A phenotype that is the inability of females to produce fertilized eggs as a result of mating. phenotypic_class FBcv:0000366 The cause of sterility may be physical or behavioral. Note: this term should not be used with the qualifier 'partially' - use semi-sterile or semi-fertile instead. female sterile FBcv:0000366 A phenotype that is the inability of females to produce fertilized eggs as a result of mating. FBC:AO FBC:CP FBC:DOS A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating to below 50% of wild-type. phenotypic_class FBcv:0000367 female semi-sterile FBcv:0000367 A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating to below 50% of wild-type. FBC:AO FBC:CP FBC:DOS A phenotype of female sterility due to defects in the female germline. female sterile germ-line-dependent phenotypic_class FBcv:0000368 female sterile germline-dependent FBcv:0000368 A phenotype of female sterility due to defects in the female germline. FBC:DOS A phenotype of female sterility due to defects in somatic cells of the ovary (FBbt:00006030), or of the products of these cells (such as eggshell). phenotypic_class FBcv:0000369 female sterile soma-dependent FBcv:0000369 A phenotype of female sterility due to defects in somatic cells of the ovary (FBbt:00006030), or of the products of these cells (such as eggshell). FBC:DOS A phenotype that is the inability of males to produce fertilized eggs as a result of mating. phenotypic_class FBcv:0000370 The cause of sterility may be physical or behavioral. Note - this term should not be used with the qualifier 'partially' - use semi-sterile or semi-fertile instead. male sterile FBcv:0000370 A phenotype that is the inability of males to produce fertilized eggs as a result of mating. FBC:AO FBC:CP FBC:DOS A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating to below 50% of wild-type. phenotypic_class FBcv:0000371 male semi-sterile FBcv:0000371 A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating to below 50% of wild-type. FBC:AO FBC:CP FBC:DOS A phenotype of male sterility due to defects in the male germline. male sterile germ-line-dependent phenotypic_class FBcv:0000372 male sterile germline-dependent FBcv:0000372 A phenotype of male sterility due to defects in the male germline. FBC:DOS A phenotype of male sterility due to defects in somatic cells of the testis (FBbt:00006031) or of the products of these cells. phenotypic_class FBcv:0000373 male sterile soma-dependent FBcv:0000373 A phenotype of male sterility due to defects in somatic cells of the testis (FBbt:00006031) or of the products of these cells. FBC:DOS A phenotype that is the ability to produce fertilized eggs as a result of mating. phenotypic_class FBcv:0000374 Note, this term should not be used with the qualifier 'partially'. Use semi-sterile or semi-fertile instead. fertile FBcv:0000374 A phenotype that is the ability to produce fertilized eggs as a result of mating. FBC:AO FBC:CP FBC:DOS A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating, but only to > 50% of wild-type. phenotypic_class FBcv:0000375 semi-fertile FBcv:0000375 A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating, but only to > 50% of wild-type. FBC:AO FBC:CP FBC:DOS A phenotype that is the ability of males to produce fertilized eggs as a result of mating. phenotypic_class FBcv:0000376 Note - this term should not be used with the qualifier 'partially' - use male semi-sterile or male semi-fertile instead. male fertile FBcv:0000376 A phenotype that is the ability of males to produce fertilized eggs as a result of mating. FBC:AO FBC:CP FBC:DOS A phenotype that is the ability of females to produce fertilized eggs as a result of mating. phenotypic_class FBcv:0000377 Note - this term should not be used with the qualifier 'partially' - use female semi-sterile or female semi-fertile instead. female fertile FBcv:0000377 A phenotype that is the ability of females to produce fertilized eggs as a result of mating. FBC:AO FBC:CP FBC:DOS A phenotype in which all offspring are sterile. Typically, this is due to maternal effect sterility resulting from defects in pole cell development. phenotypic_class FBcv:0000378 grandchildless FBcv:0000378 A phenotype in which all offspring are sterile. Typically, this is due to maternal effect sterility resulting from defects in pole cell development. ISBN:978-0-87969-321-3 Genotype g1 is an enhancer of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is greater than that caused by g2 alone. phenotypic_class FBcv:0000379 Typically, g2 is a chromosomal aberration or an insertion. enhancer of variegation FBcv:0000379 Genotype g1 is an enhancer of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is greater than that caused by g2 alone. FBC:DOS Genotype g1 is a non-enhancer of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not greater than that caused by g2 alone. phenotypic_class FBcv:0000380 non-enhancer of variegation FBcv:0000380 Genotype g1 is a non-enhancer of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not greater than that caused by g2 alone. FBC:DOS Genotype g1 is a suppressor of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is less than that caused by to g2 alone. phenotypic_class FBcv:0000381 Typically, g2 is a chromosomal aberration or an insertion. suppressor of variegation FBcv:0000381 Genotype g1 is a suppressor of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is less than that caused by to g2 alone. FBC:DOS Genotype g1 is a non-suppressor of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not less than that caused by g2 alone. phenotypic_class FBcv:0000382 non-suppressor of variegation FBcv:0000382 Genotype g1 is a non-suppressor of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not less than that caused by g2 alone. FBC:DOS A phenotype that is the inability to synthesize some organic compound that can be synthesized by wild-type animals, and that is required for normal growth and/or development. phenotypic_class FBcv:0000383 auxotroph FBcv:0000383 A phenotype that is the inability to synthesize some organic compound that can be synthesized by wild-type animals, and that is required for normal growth and/or development. http://en.wikipedia.org/wiki/Auxotrophic Phenotype that is any abnormality in aging. aging defective phenotypic_class FBcv:0000384 abnormal aging FBcv:0000384 Phenotype that is any abnormality in aging. GOC:PO_curators Phenotype that is a shorter adult life-span than wild-type. increased adult mortality phenotypic_class FBcv:0000385 short lived FBcv:0000385 Phenotype that is a shorter adult life-span than wild-type. FBC:DOS Phenotype that is a longer adult life-span than wild-type. phenotypic_class FBcv:0000386 long lived FBcv:0000386 Phenotype that is a longer adult life-span than wild-type. FBC:DOS Phenotype that is any abnormality in behavior (GO:0007610). 'behavior' is defined as: 'The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.' behavior defective behaviour defective behavioural phenotypic_class behavioral FBcv:0000387 abnormal behavior FBcv:0000387 Phenotype that is any abnormality in behavior (GO:0007610). 'behavior' is defined as: 'The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.' GOC:ems GOC:jl ISBN:0395448956 PMID:20160973 Phenotype that is a change in the strong tendency, seen in wild-type Drosophila melanogaster, to climb - a behavior otherwise known as negative gravitaxis (GO:0048060 ; movement away from the source of gravity). gravitaxis defective phenotypic_class geotaxis behaviour defective gravitaxis behavior defective FBcv:0000388 Note, this term should not be used when flies have climbing defects purely as a consequence of locomotion defects, use 'locomotor behavior defective' instead. abnormal gravitaxis FBcv:0000388 Phenotype that is a change in the strong tendency, seen in wild-type Drosophila melanogaster, to climb - a behavior otherwise known as negative gravitaxis (GO:0048060 ; movement away from the source of gravity). FBC:DOS Phenotype that is a disposition to paralysis under conditions that do not cause paralysis in a wild-type animal. Paralysis is defined as an inability to exhibit `multicellular organismal movement` (GO:0050879) phenotypic_class FBcv:0000389 paralytic FBcv:0000389 Phenotype that is a disposition to paralysis under conditions that do not cause paralysis in a wild-type animal. Paralysis is defined as an inability to exhibit `multicellular organismal movement` (GO:0050879) FBC:DOS A phenotype consisting of an decrease in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type. hypoactive reduced rate of movement phenotypic_class FBcv:0000390 decreased rate of movement FBcv:0000390 A phenotype consisting of an decrease in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type. FBC:DOS A phenotype exhibited following mechanical shock and consisting of a brief period of intense, uncoordinated motor activity (legs and wings flailing, abdomen coiling) followed by a prolonged period of paralysis. phenotypic_class easily shocked FBcv:0000391 bang sensitive FBcv:0000391 A phenotype exhibited following mechanical shock and consisting of a brief period of intense, uncoordinated motor activity (legs and wings flailing, abdomen coiling) followed by a prolonged period of paralysis. FlyBase:FBrf0022877 easily shocked FlyBase:FBrf0022877 A phenotype consisting of an increase in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type. hyperactive phenotypic_class FBcv:0000392 increased rate of movement FBcv:0000392 A phenotype consisting of an increase in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type. FBC:DOS Phenotype that is any abnormality in response to pain (GO:0048265). 'response to pain' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.' pain response defective phenotypic_class FBcv:0000393 abnormal pain response FBcv:0000393 Phenotype that is any abnormality in response to pain (GO:0048265). 'response to pain' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.' FBC:DOS GOC:jid PMID:10203867 PMID:12723742 PMID:12843304 Wikipedia:Pain Phenotype that is any abnormality in circadian rhythm (GO:0007623). 'circadian rhythm' is defined as: 'Any biological process in an organism that recurs with a regularity of approximately 24 hours.' circadian rhythm defective phenotypic_class FBcv:0000394 abnormal circadian rhythm FBcv:0000394 Phenotype that is any abnormality in circadian rhythm (GO:0007623). 'circadian rhythm' is defined as: 'Any biological process in an organism that recurs with a regularity of approximately 24 hours.' FBC:DOS GOC:bf GOC:go_curators Phenotype that is any abnormality in locomotor rhythm (GO:0045475). 'locomotor rhythm' is defined as: 'The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.' locomotor rhythm defective phenotypic_class FBcv:0000395 abnormal locomotor rhythm FBcv:0000395 Phenotype that is any abnormality in locomotor rhythm (GO:0045475). 'locomotor rhythm' is defined as: 'The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.' FBC:DOS GOC:go_curators Phenotype that is any abnormality in eclosion rhythm (GO:0008062). 'eclosion rhythm' is defined as: 'The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.' eclosion rhythm defective phenotypic_class FBcv:0000396 abnormal eclosion rhythm FBcv:0000396 Phenotype that is any abnormality in eclosion rhythm (GO:0008062). 'eclosion rhythm' is defined as: 'The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.' FBC:DOS PMID:11715043 Phenotype that is any abnormality in learning (GO:0007612). 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.' learning defective phenotypic_class FBcv:0000397 abnormal learning FBcv:0000397 Phenotype that is any abnormality in learning (GO:0007612). 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.' FBC:DOS ISBN:0582227089 ISBN:0721662544 Phenotype that is any abnormality in memory (GO:0007613). 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).' memory defective phenotypic_class FBcv:0000398 abnormal memory FBcv:0000398 Phenotype that is any abnormality in memory (GO:0007613). 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).' FBC:DOS GOC:curators ISBN:0582227089 Phenotype that is any abnormality in courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.' courtship behavior defective phenotypic_class FBcv:0000399 abnormal courtship behavior FBcv:0000399 Phenotype that is any abnormality in courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.' FBC:DOS GOC:ai GOC:dph Phenotype that is any abnormality in mating (GO:0007618). 'mating' is defined as: 'The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.' mating defective phenotypic_class FBcv:0000400 abnormal mating FBcv:0000400 Phenotype that is any abnormality in mating (GO:0007618). 'mating' is defined as: 'The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.' FBC:DOS GOC:jl ISBN:0387520546 Phenotype that is any abnormality in circadian mating behavior (GO:0035648). 'circadian mating behavior' is defined as: 'The fluctuation in mating behavior that occurs over an approximately 24 hour cycle.' mating rhythm defective phenotypic_class FBcv:0000401 abnormal mating rhythm FBcv:0000401 Phenotype that is any abnormality in circadian mating behavior (GO:0035648). 'circadian mating behavior' is defined as: 'The fluctuation in mating behavior that occurs over an approximately 24 hour cycle.' FBC:DOS GOC:bf GOC:dos PMID:11470898 PMID:17276917 Phenotype that is any abnormality in male courtship behavior, veined wing generated song production (GO:0045433). This is defined as 'The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.' singing defective song defective song production defective phenotypic_class FBcv:0000402 abnormal song FBcv:0000402 Phenotype that is any abnormality in male courtship behavior, veined wing generated song production (GO:0045433). This is defined as 'The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.' FBC:DOS GOC:mtg_sensu PMID:11092827 singing defective FBC:SM song production defective FBC:SM Phenotype that is any abnormality in chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'. abnormal chemosensitive behavior chemosensitive behavior defective chemosensitive behaviour defective phenotypic_class FBcv:0000403 abnormal chemosensory behavior FBcv:0000403 Phenotype that is any abnormality in chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'. FBC:DOS GOC:go_curators Phenotype that is any abnormality in sensory perception of smell (GO:0007608). 'sensory perception of smell' is defined as: 'The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.' olfaction defective smell perception defective phenotypic_class FBcv:0000404 abnormal smell perception FBcv:0000404 Phenotype that is any abnormality in sensory perception of smell (GO:0007608). 'sensory perception of smell' is defined as: 'The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.' FBC:DOS GOC:ai Phenotype that is any abnormality in sensory perception of taste (GO:0050909). 'sensory perception of taste' is defined as: 'The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.' gustation defective taste defective taste perception defective phenotypic_class FBcv:0000405 abnormal taste perception FBcv:0000405 Phenotype that is any abnormality in sensory perception of taste (GO:0050909). 'sensory perception of taste' is defined as: 'The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.' FBC:DOS GOC:ai Phenotype that is any abnormality in or absense of proboscis extension reflex in response to a sugar stimulus via taste sensilla on the tarsus. tarsal response defective phenotypic_class FBcv:0000406 abnormal tarsal response FBcv:0000406 Phenotype that is any abnormality in or absense of proboscis extension reflex in response to a sugar stimulus via taste sensilla on the tarsus. FBC:DOS Phenotype that is any abnormality in sensory perception of sound (GO:0007605). 'sensory perception of sound' is defined as: 'The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.' auditory perception defective phenotypic_class auditory system defective FBcv:0000407 abnormal auditory perception FBcv:0000407 Phenotype that is any abnormality in sensory perception of sound (GO:0007605). 'sensory perception of sound' is defined as: 'The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.' FBC:DOS GOC:ai Phenotype that is any abnormality in response to stress (GO:0006950). 'response to stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).' stress response defective environmental stress response defective phenotypic_class FBcv:0000408 abnormal stress response FBcv:0000408 Phenotype that is any abnormality in response to stress (GO:0006950). 'response to stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).' FBC:DOS GOC:mah Phenotype that is any abnormality in response to osmotic stress (GO:0006970). 'response to osmotic stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.' osmotic stress response defective phenotypic_class FBcv:0000409 abnormal osmotic stress response FBcv:0000409 Phenotype that is any abnormality in response to osmotic stress (GO:0006970). 'response to osmotic stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.' FBC:DOS GOC:jl Phenotype that is any abnormality in response to heat (GO:0009408). 'response to heat' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.' heat stress response defective phenotypic_class FBcv:0000410 abnormal heat stress response FBcv:0000410 Phenotype that is any abnormality in response to heat (GO:0009408). 'response to heat' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.' FBC:DOS GOC:lr Phenotype that is any abnormality in visual behavior (GO:0007632). 'visual behavior' is defined as: 'The behavior of an organism in response to a visual stimulus.' visual behavior defective visual behaviour defective phenotypic_class FBcv:0000411 abnormal visual behavior FBcv:0000411 Phenotype that is any abnormality in visual behavior (GO:0007632). 'visual behavior' is defined as: 'The behavior of an organism in response to a visual stimulus.' FBC:DOS GOC:jid GOC:pr Phenotype that is any abnormality in optomotor response: a motor response during flight or walking that serves to stabilize both image formation on the retina and locomotor course. optomotor behaviour defective optomotor response defective phenotypic_class FBcv:0000412 abnormal optomotor response FBcv:0000412 Phenotype that is any abnormality in optomotor response: a motor response during flight or walking that serves to stabilize both image formation on the retina and locomotor course. FBC:DOS Phenotype that is any abnormality in phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.' phototaxis defective phenotypic_class phototaxis behaviour defective FBcv:0000413 abnormal phototaxis FBcv:0000413 Phenotype that is any abnormality in phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.' FBC:DOS GOC:jl ISBN:0192800981 Phenotype that is any abnormality in locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.' locomotor behavior defective locomotor behaviour defective phenotypic_class FBcv:0000414 abnormal locomotor behavior FBcv:0000414 Phenotype that is any abnormality in locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.' FBC:DOS GOC:dph Phenotype that is a reduced ability to jump or a reduced jump response. This may be due to neurological or muscular defects. jumping defective phenotypic_class FBcv:0000415 abnormal jumping FBcv:0000415 Phenotype that is a reduced ability to jump or a reduced jump response. This may be due to neurological or muscular defects. FBC:DOS Phenotype that is abnormal co-ordination of motor activity. phenotypic_class FBcv:0000416 uncoordinated FBcv:0000416 Phenotype that is abnormal co-ordination of motor activity. FBC:CP FBC:DOS Phenotype that is any abnormality in flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.' flight defective flight behaviour defective phenotypic_class FBcv:0000417 This term is agnostic as to the causes of defects in flight. An animal's flight may be defective for mechanical, behavioral or sensory reasons. abnormal flight FBcv:0000417 Phenotype that is any abnormality in flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.' FBC:DOS GOC:dph Phenotype that is the absence of flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.' phenotypic_class FBcv:0000418 This term is agnostic as to the causes of flightlessness. An animal may be flightless for mechanical or behavioral reasons. flightless FBcv:0000418 Phenotype that is the absence of flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.' FBC:DOS GOC:dph Phenotype that is any abnormality in feeding behavior (GO:0007631). 'feeding behavior' is defined as: 'Behavior associated with the intake of food.' feeding behavior defective feeding behaviour defective phenotypic_class FBcv:0000419 abnormal feeding behavior FBcv:0000419 Phenotype that is any abnormality in feeding behavior (GO:0007631). 'feeding behavior' is defined as: 'Behavior associated with the intake of food.' FBC:DOS GOC:mah Phenotype that is any abnormality in grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.' grooming behavior defective grooming behaviour defective phenotypic_class FBcv:0000420 abnormal grooming behavior FBcv:0000420 Phenotype that is any abnormality in grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.' FBC:DOS GOC:jl GOC:pr Phenotype that is any abnormality in or loss of a stereotypical behavioral response to touch. touch response defective touch sensitivity defective phenotypic_class FBcv:0000421 This phenotype is commonly assayed by scoring larval avoidance responses following stroking of the thoracic segments (see Kernan et al., 1994). On its own, this is not sufficient evidence for an abnormality in sensory perception of touch, as motor defects can also cause this phenotype. abnormal touch response FBcv:0000421 Phenotype that is any abnormality in or loss of a stereotypical behavioral response to touch. FlyBase:FBrf0073546 Phenotype that is any abnormality in entrainment of circadian clock by photoperiod (GO:0043153), which is defined as: 'The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).' phenotypic_class FBcv:0000422 photoperiod response variant FBcv:0000422 Phenotype that is any abnormality in entrainment of circadian clock by photoperiod (GO:0043153), which is defined as: 'The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).' FBC:DOS GOC:jl Phenotype that is any abnormality in DNA repair (GO:0006281). 'DNA repair' is defined as: 'The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.' DNA repair defective phenotypic_class FBcv:0000423 abnormal DNA repair FBcv:0000423 Phenotype that is any abnormality in DNA repair (GO:0006281). 'DNA repair' is defined as: 'The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.' FBC:DOS PMID:11563486 Phenotype that is a change in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. This may be due to effects on the regulation of cell death (GO:0010941) or in cell death (GO:0008219) pathways themselves. cell death defective apoptosis defective pcd defective programmed cell death defective phenotypic_class FBcv:0000424 abnormal cell death FBcv:0000424 Phenotype that is a change in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. This may be due to effects on the regulation of cell death (GO:0010941) or in cell death (GO:0008219) pathways themselves. FBC:DOS Phenotype that is an increase in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. pcd increase programmed cell death increase phenotypic_class FBcv:0000425 increased cell death FBcv:0000425 Phenotype that is an increase in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. FBC:DOS Phenotype that is a decrease in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. reduced cell death pcd decrease programmed cell death decrease phenotypic_class FBcv:0000426 decreased cell death FBcv:0000426 Phenotype that is a decrease in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. FBC:DOS Phenotype that is any abnormality in cell growth (GO:0016049). 'cell growth' is defined as: 'The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.' cell growth defective phenotypic_class FBcv:0000427 Note that defects in cell size are not necessarily the result of defects in cell growth. A change in the rate of cell division in the absence of any change in cell growth rate can result in smaller or larger cells. abnormal cell growth FBcv:0000427 Phenotype that is any abnormality in cell growth (GO:0016049). 'cell growth' is defined as: 'The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.' FBC:DOS GOC:ai Phenotype that is any abnormality in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. cell size defective phenotypic_class FBcv:0000428 abnormal cell size FBcv:0000428 Phenotype that is any abnormality in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. FBC:DOS Phenotype that is any abnormality in the shape (PATO:0000052) of some cell compared to wild-type. cell shape defective phenotypic_class FBcv:0000429 abnormal cell shape FBcv:0000429 Phenotype that is any abnormality in the shape (PATO:0000052) of some cell compared to wild-type. FBC:DOS Phenotype that is any abnormality in the asymmetric distribution of components within a cell. For example an epithelial cell is 'cell polarity defective' if it lacks the normal asymmetric distribution of proteins or cell components such as junctions or villi along its apical-basal axis. cell polarity defective phenotypic_class FBcv:0000430 abnormal cell polarity FBcv:0000430 Phenotype that is any abnormality in the asymmetric distribution of components within a cell. For example an epithelial cell is 'cell polarity defective' if it lacks the normal asymmetric distribution of proteins or cell components such as junctions or villi along its apical-basal axis. FBC:DOS Phenotype that is any abnormality in meiotic cell cycle (GO:0051321). 'meiotic cell cycle' is defined as: 'Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.' meiotic cell cycle defective phenotypic_class meiotic FBcv:0000431 abnormal meiotic cell cycle FBcv:0000431 Phenotype that is any abnormality in meiotic cell cycle (GO:0051321). 'meiotic cell cycle' is defined as: 'Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.' FBC:DOS GOC:ai Phenotype that is any abnormality in mitotic cell cycle (GO:0000278). 'mitotic cell cycle' is defined as: 'Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.' mitotic cell cycle defective phenotypic_class mitotic FBcv:0000432 abnormal mitotic cell cycle FBcv:0000432 Phenotype that is any abnormality in mitotic cell cycle (GO:0000278). 'mitotic cell cycle' is defined as: 'Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.' FBC:DOS GOC:mah ISBN:0815316194 Phenotype that is any abnormality in cytokinesis (GO:0000910). 'cytokinesis' is defined as: 'The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.' cytokinesis defective phenotypic_class FBcv:0000433 abnormal cytokinesis FBcv:0000433 Phenotype that is any abnormality in cytokinesis (GO:0000910). 'cytokinesis' is defined as: 'The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.' FBC:DOS GOC:mtg_cell_cycle Phenotype that is any abnormality in the electrophysiological properties of some class of neurons, muscles or other anatomical structure of the nervous system. Examples of these phenotypes at the neuron class level include defects in spontaneous or evoked excitatory junction potential. Examples at a more gross anatomical level include abnormal retinal electrophysiology (e.g.- measured by an electroretinogram). neurophysiology defective phenotypic_class FBcv:0000434 abnormal neurophysiology FBcv:0000434 Phenotype that is any abnormality in the electrophysiological properties of some class of neurons, muscles or other anatomical structure of the nervous system. Examples of these phenotypes at the neuron class level include defects in spontaneous or evoked excitatory junction potential. Examples at a more gross anatomical level include abnormal retinal electrophysiology (e.g.- measured by an electroretinogram). FBC:DOS Phenotype that is any abnormality in the anatomy of the nervous system (FBbt:00005093). 'nervous system' is defined as: 'All the nerve centers and nerve fibers in the central, visceral and peripheral nervous systems.' neuroanatomy defective phenotypic_class FBcv:0000435 abnormal neuroanatomy FBcv:0000435 Phenotype that is any abnormality in the anatomy of the nervous system (FBbt:00005093). 'nervous system' is defined as: 'All the nerve centers and nerve fibers in the central, visceral and peripheral nervous systems.' FBC:DOS FlyBase:FBrf0166419 Phenotype that is any abnormality in sex determination (GO:0007530). 'sex determination' is defined as: 'Any process that establishes and transmits the specification of sexual status of an individual organism.' sex-determination defective phenotypic_class FBcv:0000436 abnormal sex-determination FBcv:0000436 Phenotype that is any abnormality in sex determination (GO:0007530). 'sex determination' is defined as: 'Any process that establishes and transmits the specification of sexual status of an individual organism.' FBC:DOS ISBN:0198506732 FBcv:0000436 phenotypic_class FBcv:0000437 This term was obsoleted because it was felt that the evidence provided in papers is not enough to annotate with this term. mc161014 obsolete dosage compensation defective true FBcv:0000437 Phenotype that is a difference in electrophoretic migration of a gene product compared to wild-type. phenotypic_class FBcv:0000438 electrophoretic variant FBcv:0000438 Phenotype that is a difference in electrophoretic migration of a gene product compared to wild-type. FBC:DOS Phenotype that is a decreased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death. phenotypic_class FBcv:0000439 chemical resistant FBcv:0000439 Phenotype that is a decreased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death. FBC:DOS Phenotype that is an increased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death. phenotypic_class FBcv:0000440 chemical sensitive FBcv:0000440 Phenotype that is an increased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death. FBC:DOS Phenotype that is a decreased tendency for radiation exposure to cause toxic effects. phenotypic_class FBcv:0000441 radiation resistant FBcv:0000441 Phenotype that is a decreased tendency for radiation exposure to cause toxic effects. FBC:DOS Phenotype that is an increased tendency for radiation exposure to cause toxic effects. phenotypic_class FBcv:0000442 radiation sensitive FBcv:0000442 Phenotype that is an increased tendency for radiation exposure to cause toxic effects. FBC:DOS Dominant phenotype consisting of short slender bristles and delayed development. Homozygotes are cell lethal. phenotypic_class FBcv:0000443 The phenotype may be a general result of mutations in essential components of the protein synthesis pathway, as a number of Minutes encode ribosomal proteins. In an animal that is heterozygous for a Minute mutation, cells with two wild-type alleles of the affected gene have a growth advantage. Many developmental studies take advantage of this fact to give somatic clones a growth advantage. The term 'Minute' should not be used to annotate the resulting phenotypes. Minute FBcv:0000443 Dominant phenotype consisting of short slender bristles and delayed development. Homozygotes are cell lethal. FlyBase:FBrf0066905 Phenotype that is an increase in the number of cells in a tissue or organ, usually associated with an increase in size, where the affected tissue or organ maintains its normal form. hyperplastic phenotypic_class FBcv:0000444 hyperplasia FBcv:0000444 Phenotype that is an increase in the number of cells in a tissue or organ, usually associated with an increase in size, where the affected tissue or organ maintains its normal form. ISBN:978-0-19-850673-7 Phenotype that is characterized by the formation of abnormal masses of tissue (tumors) as the result of neoplasia. FBcv:0000723 phenotypic_class FBcv:0000445 Obsoleted as this is the same phenotype as neoplasia. obsolete tumorigenic true FBcv:0000445 Phenotype that is characterized by the formation of abnormal masses of tissue (tumors) as the result of neoplasia. FBC:DOS Phenotype characterized by the formation of lumps of melanotic tissue inside the body in the absence of foreign bodies or wounding. melanization melanotic nodule phenotypic_class melanotic tumor pseudotumor FBcv:0000446 Melanotic capsules are formed around wounds and foreign bodies in wild-type animals as part of the immune response, for example as a protection against parasitoid wasps. For the wild-type structure, consider FBbt:00005064. Some, but not all melanotic mass phenotypes involve ectopic activation of the same immune response. Melanotic masses caused by genetic manipulations are sometimes referred to as 'melanotic tumors' or 'pseudotumors', but this is a misnomer as they are rarely neoplastic (Minakhina and Steward, 2006). melanotic mass phenotype FBcv:0000446 Phenotype characterized by the formation of lumps of melanotic tissue inside the body in the absence of foreign bodies or wounding. FlyBase:FBrf0094387 FlyBase:FBrf0194475 melanization FlyBase:FBrf0194475 melanotic nodule FlyBase:FBrf0194475 melanotic tumor FlyBase:FBrf0194475 pseudotumor FlyBase:FBrf0194475 Phenotype characterized by closely associated necrosis and melanization. phenotypic_class FBcv:0000447 melanotic necrosis FBcv:0000447 Phenotype characterized by closely associated necrosis and melanization. FlyBase:FBrf0155704 Phenotype that is any abnormality in immune response (GO:0006955). 'immune response' is defined as: 'Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.' immune response defective phenotypic_class FBcv:0000448 abnormal immune response FBcv:0000448 Phenotype that is any abnormality in immune response (GO:0006955). 'immune response' is defined as: 'Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.' FBC:DOS GOC:add GO_REF:0000022 Phenotype that is any abnormality in establishment of planar polarity (GO:0001736). 'establishment of planar polarity' is defined as: 'Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.' tissue polarity defective planar polarity defective phenotypic_class FBcv:0000449 For apical-basal polarity phenotypes of epithelia, the appropriate term is 'cell polarity defective'. abnormal planar polarity FBcv:0000449 Phenotype that is any abnormality in establishment of planar polarity (GO:0001736). 'establishment of planar polarity' is defined as: 'Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.' GOC:dph Phenotype that is a change in any kind of rate (e.g. speed, frequency) of any developmental process (GO:0032502) taking place prior to mature adulthood (defined as adult stage A3), compared to wild-type. Note, developmental processes include stages in development of the whole animal (e.g. larval development) as well as specific sub-processes, such as dorsal closure. developmental rate defective phenotypic_class FBcv:0000450 A more complete formalization would require a clause specifying stage. It might be possible to do this in OWL using the same system as we are using for lethal phase. abnormal developmental rate FBcv:0000450 Phenotype that is a change in any kind of rate (e.g. speed, frequency) of any developmental process (GO:0032502) taking place prior to mature adulthood (defined as adult stage A3), compared to wild-type. Note, developmental processes include stages in development of the whole animal (e.g. larval development) as well as specific sub-processes, such as dorsal closure. FBC:DOS Phenotype that is any abnormality in wound healing (GO:0042060). 'wound healing' is defined as: 'The series of events that restore integrity to a damaged tissue, following an injury.' wound healing defective phenotypic_class FBcv:0000451 abnormal wound healing FBcv:0000451 Phenotype that is any abnormality in wound healing (GO:0042060). 'wound healing' is defined as: 'The series of events that restore integrity to a damaged tissue, following an injury.' GOC:bf PMID:15269788 Describes the origin of the mutation that causes a phenotype. origin_of_mutation FBcv:0000452 origin of mutation FBcv:0000452 Describes the origin of the mutation that causes a phenotype. FBC:MMC FlyBase miscellaneous CV FBcv:0000453 obsolete piggyBac ammunition for transposable element mutagenesis true FBcv:0000453 origin_of_mutation FBcv:0000454 obsolete synthetic true FBcv:0000454 DNA change introduced by using an in vitro construct. The sequence of the in vitro construct determines the type of change. change induced by in vitro construct origin_of_mutation FBcv:0000455 in vitro construct FBcv:0000455 DNA change introduced by using an in vitro construct. The sequence of the in vitro construct determines the type of change. FBC:MMC Sequence change introduced by using an in vitro construct that contains a fusion of the regulatory region of one gene on to the coding region of another. Examples in FlyBase include heat shock constructs, FRT flip out constructs and reporter genes. change induced by an in vitro construct - regulatory fusion origin_of_mutation in vitro construct | regulatory fusion FBcv:0000456 This term has been obsoleted because the nature of an in vitro construct (e.g. 'regulatory fusion') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information. obsolete in vitro construct - regulatory fusion true FBcv:0000456 Sequence change introduced by using an in vitro construct that contains a fusion of the regulatory region of one gene on to the coding region of another. Examples in FlyBase include heat shock constructs, FRT flip out constructs and reporter genes. FBC:DOS Sequence change introduced by using an in vitro construct that contains a in-frame fusion of the open reading frames from two or more genes. In FlyBase, the resulting genes may be classified as fusion genes or tagged genes. change induced by an in vitro construct - coding region fusion origin_of_mutation in vitro construct | coding region fusion FBcv:0000457 This term has been obsoleted because the nature of an in vitro construct (e.g. 'coding region fusion') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information. obsolete in vitro construct - coding region fusion true FBcv:0000457 Sequence change introduced by using an in vitro construct that contains a in-frame fusion of the open reading frames from two or more genes. In FlyBase, the resulting genes may be classified as fusion genes or tagged genes. FBC:DOS Mutation induced by an in vitro construct that uses site directed mutagenesis to target a particular region of the gene. mutation induced by an in vitro construct - site directed mutagenesis origin_of_mutation in vitro construct | site directed mutagenesis FBcv:0000458 This term has been obsoleted because the nature of an in vitro construct (e.g. 'site directed mutagenesis') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information. obsolete in vitro construct - site directed mutagenesis true FBcv:0000458 Mutation induced by an in vitro construct that uses site directed mutagenesis to target a particular region of the gene. FBC:DOS Sequence change introduced by an in vitro construct generated by internal deletion of some genomic sequence or cDNA. change induced by an in vitro construct - deletion origin_of_mutation in vitro construct | deletion FBcv:0000459 This term has been obsoleted because the nature of an in vitro construct (e.g. 'deletion') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information. obsolete in vitro construct - deletion true FBcv:0000459 Sequence change introduced by an in vitro construct generated by internal deletion of some genomic sequence or cDNA. FBC:DOS Sequence change introduced by an in vitro construct containing a genomic fragment that partially or fully rescues loss of function mutations or deletions of the gene whose sequence it carries. change induced by an in vitro construct - genomic fragment origin_of_mutation in vitro construct | genomic fragment FBcv:0000460 This term has been obsoleted because the nature of an in vitro construct (e.g. 'genomic fragment') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information. obsolete in vitro construct - genomic fragment true FBcv:0000460 Sequence change introduced by an in vitro construct containing a genomic fragment that partially or fully rescues loss of function mutations or deletions of the gene whose sequence it carries. FBC:DOS Sequence change introduced by an in vitro construct that contains the wild-type open reading frame of a gene (without introns), the expression of which is controlled by a wild-type promoter of the same gene. Such constructs are often generated by fusing a cDNA to a genomic region containing promoter sequences, or more rarely by deletion of introns and other non-essential sequences from a genomic region, leaving a wild type coding region and promoter intact. change induced by an in vitro construct - minigene origin_of_mutation in vitro construct | minigene FBcv:0000461 This term has been obsoleted because the nature of an in vitro construct (e.g. 'minigene') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information. obsolete in vitro construct - minigene true FBcv:0000461 Sequence change introduced by an in vitro construct that contains the wild-type open reading frame of a gene (without introns), the expression of which is controlled by a wild-type promoter of the same gene. Such constructs are often generated by fusing a cDNA to a genomic region containing promoter sequences, or more rarely by deletion of introns and other non-essential sequences from a genomic region, leaving a wild type coding region and promoter intact. FBC:DOS Sequence change introduced by an in vitro construct that uses site directed mutagenesis to target a particular region of the gene resulting in a change to the change to the amino acids sequence encodes.. change induced by an in vitro construct - amino acid replacement origin_of_mutation in vitro construct | amino acid replacement FBcv:0000462 This term has been obsoleted because the nature of an in vitro construct (e.g. 'amino acid replacement') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information. obsolete in vitro construct - amino acid replacement true FBcv:0000462 Sequence change introduced by an in vitro construct that uses site directed mutagenesis to target a particular region of the gene resulting in a change to the change to the amino acids sequence encodes.. FBC:DOS Sequence change introduced by an in vitro construct designed to generate dsRNA for RNA interference (RNAi) experiments. change induced by an in vitro construct - RNAi origin_of_mutation in vitro construct | RNAi FBcv:0000463 This term has been obsoleted because the nature of an in vitro construct (e.g. 'RNAi') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information. obsolete in vitro construct - RNAi true FBcv:0000463 Sequence change introduced by an in vitro construct designed to generate dsRNA for RNA interference (RNAi) experiments. FBC:DOS in vitro construct | other origin_of_mutation FBcv:0000464 obsolete in vitro construct - other true FBcv:0000464 Mutation found in a natural population. origin_of_mutation FBcv:0000465 natural population FBcv:0000465 Mutation found in a natural population. FBC:MMC Mutation caused by exposure to a temperature that is higher or lower than 25 degrees Celsius. mutation induced by temperature treatment origin_of_mutation environmental treatment FBcv:0000466 temperature FBcv:0000466 Mutation caused by exposure to a temperature that is higher or lower than 25 degrees Celsius. FBC:MMC Mutation induced by exposure to temperature that is lower than 25 degrees Celsius. mutation induced by cold treatment origin_of_mutation cold-treatment FBcv:0000467 cold FBcv:0000467 Mutation induced by exposure to temperature that is lower than 25 degrees Celsius. FBC:MMC Mutation induced by exposure to a temperature that is higher than 25 degrees Celsius. mutation induced by heat treatment origin_of_mutation heat-treatment FBcv:0000468 heat FBcv:0000468 Mutation induced by exposure to a temperature that is higher than 25 degrees Celsius. FBC:MMC Mutation caused by a spontaneous event. mutation induced by spontaneous event origin_of_mutation FBcv:0000469 spontaneous FBcv:0000469 Mutation caused by a spontaneous event. FBC:MMC Sequence change induced by the genetic exchange that takes place between DNA sequences. change induced by recombination origin_of_mutation FBcv:0000470 recombination FBcv:0000470 Sequence change induced by the genetic exchange that takes place between DNA sequences. FBC:MC ISBN:978-0-8153-3218-3 Sequence change caused by a DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor (GO:0035822). change induced by gene conversion origin_of_mutation FBcv:0000471 Strictly, gene conversion (GO:0035822) defines only the endogenous process, not its use for engineered gene targeting. gene conversion FBcv:0000471 Sequence change caused by a DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor (GO:0035822). PMID:17846636 Mutation caused by a recombination event that causes the unequal exchange of small intralocus regions, usually leading to the formation of duplication and deficiency products. mutation induced by intralocus exchange origin_of_mutation FBcv:0000472 intralocus exchange FBcv:0000472 Mutation caused by a recombination event that causes the unequal exchange of small intralocus regions, usually leading to the formation of duplication and deficiency products. FBC:MC FlyBase:FBrf0014117 FlyBase:FBrf0202435 Sequence change caused by a recombination event that causes an unequal exchange of genetic material between homologous or non-homologous regions. change induced by unequal recombination origin_of_mutation FBcv:0000473 unequal recombination FBcv:0000473 Sequence change caused by a recombination event that causes an unequal exchange of genetic material between homologous or non-homologous regions. FlyBase:FBrf0202435 Sequence change caused by the exchange of genetic material during mitosis that occurs at crossing over, and more frequently between homologous chromosomes. change induced by mitotic recombination origin_of_mutation FBcv:0000474 mitotic recombination FBcv:0000474 Sequence change caused by the exchange of genetic material during mitosis that occurs at crossing over, and more frequently between homologous chromosomes. FlyBase:FBrf0202435 Sequence change caused by a recombination event between tandem repeats of rRNA genes that causes unequal chromatid exchange at crossing over and an increase in the number of functional copies. It causes a reversion from mutant to wild-type phenotype. mutation induced by magnification origin_of_mutation FBcv:0000475 magnification FBcv:0000475 Sequence change caused by a recombination event between tandem repeats of rRNA genes that causes unequal chromatid exchange at crossing over and an increase in the number of functional copies. It causes a reversion from mutant to wild-type phenotype. FlyBase:FBrf0202435 FlyBase:FBrf0218934 Mutation that is caused by a recombination event that causes the breakdown of compound chromosome arms resulting in duplications or deletions in proximal regions. mutation induced by detachment origin_of_mutation FBcv:0000476 detachment FBcv:0000476 Mutation that is caused by a recombination event that causes the breakdown of compound chromosome arms resulting in duplications or deletions in proximal regions. FBC:MC FlyBase:FBrf0202435 Mutation caused by a recombination event between tandem repeats of rRNA genes that causes unequal chromatid exchange at crossing over and a reduction in the number of functional copies. It leads to an aggravation of phenotype, in the case of a mutation causing a change from a wildtype to mutant phenotype or a change from a mutant to a more severe mutant phenotype. mutation induced by reduction origin_of_mutation FBcv:0000477 reduction FBcv:0000477 Mutation caused by a recombination event between tandem repeats of rRNA genes that causes unequal chromatid exchange at crossing over and a reduction in the number of functional copies. It leads to an aggravation of phenotype, in the case of a mutation causing a change from a wildtype to mutant phenotype or a change from a mutant to a more severe mutant phenotype. FlyBase:FBrf0026874 Sequence change induced by a recombination event catalyzed by a recombinase that occurs at specific nucleotide sequences. change induced by site specific recombination origin_of_mutation FBcv:0000478 site specific recombination FBcv:0000478 Sequence change induced by a recombination event catalyzed by a recombinase that occurs at specific nucleotide sequences. FlyBase:FBrf0202435 ISBN:978-0-8153-3218-3 Sequence change caused by a site specific recombination event catalyzed by the tyrosine recombinase FLPase, that recognizes minimal FLP recombination target (FRT) sites of 34 base pairs. For site specific integration, the recombination site consists of 48 base pairs containing an additional isolated base pair and a third 13 base pair direct repeat. change induced by FLPase recombination origin_of_mutation FBcv:0000479 FLPase FBcv:0000479 Sequence change caused by a site specific recombination event catalyzed by the tyrosine recombinase FLPase, that recognizes minimal FLP recombination target (FRT) sites of 34 base pairs. For site specific integration, the recombination site consists of 48 base pairs containing an additional isolated base pair and a third 13 base pair direct repeat. FlyBase:FBrf0201927 UniProt:P03870 Sequence change caused by the cleavage of an 18 base pair DNA sequence by the I-SceI endonuclease. change induced by I-SceI endonuclease cleavage origin_of_mutation SCEI endonuclease FBcv:0000480 I-SceI FBcv:0000480 Sequence change caused by the cleavage of an 18 base pair DNA sequence by the I-SceI endonuclease. FlyBase:FBrf0128625 UniProt:P03882 Sequence change induced by a site specific recombination event catalyzed by the tyrosine recombinase cre. Recombination is induced between two 34 base pairs loxP sites. These consist of two 13 base pair perfect inverted repeats flanking an 8 base pair asymmetric spacer that confers directionality. change induced by cre recombinase recombination origin_of_mutation Cre recombinase FBcv:0000481 cre recombinase FBcv:0000481 Sequence change induced by a site specific recombination event catalyzed by the tyrosine recombinase cre. Recombination is induced between two 34 base pairs loxP sites. These consist of two 13 base pair perfect inverted repeats flanking an 8 base pair asymmetric spacer that confers directionality. FlyBase:FBrf0201927 PMID:6954485 UniProt:P06956 Sequence change induced by chromosomal segregation. change induced by segregation origin_of_mutation FBcv:0000482 segregation FBcv:0000482 Sequence change induced by chromosomal segregation. FBC:MMC Mutation induced by the mobilization of a transposable element. mutation induced by transposable element activity origin_of_mutation FBcv:0000483 transposable element activity FBcv:0000483 Mutation induced by the mobilization of a transposable element. FBC:MC FlyBase:FBrf0202435 Mutation caused by hybrid dysgenesis that results from the mobilization of the I-element retrotransposon. mutation induced by IR-hybrid dysgenesis origin_of_mutation IR FBcv:0000484 IR-hybrid dysgenesis FBcv:0000484 Mutation caused by hybrid dysgenesis that results from the mobilization of the I-element retrotransposon. FlyBase:FBrf0202435 Mutation induced by hybrid dysgenesis caused by the mobilization of the Stalker transposable element. mutation induced by Stalker-hybrid dysgenesis origin_of_mutation FBcv:0000485 Stalker-hybrid dysgenesis FBcv:0000485 Mutation induced by hybrid dysgenesis caused by the mobilization of the Stalker transposable element. FlyBase:FBrf0202435 Mutation induced by the transposable activity caused by a P-element, a DNA transposable element. The P-element is 2.9 kilobases in length with 31 base pairs inverted terminal repeats. Upon insertion it generates a flanking duplication of 8 base pairs at the target site upon insertion. Mobilization is induced by the activity of a P-element transposase. mutation induced by P-element activity origin_of_mutation FBcv:0000486 P-element activity FBcv:0000486 Mutation induced by the transposable activity caused by a P-element, a DNA transposable element. The P-element is 2.9 kilobases in length with 31 base pairs inverted terminal repeats. Upon insertion it generates a flanking duplication of 8 base pairs at the target site upon insertion. Mobilization is induced by the activity of a P-element transposase. FlyBase:FBrf0202435 Mutation caused by hybrid dysgenesis that results from the action of the P-element. mutation induced by PM hybrid dysgenesis origin_of_mutation FBcv:0000487 PM hybrid dysgenesis FBcv:0000487 Mutation caused by hybrid dysgenesis that results from the action of the P-element. FlyBase:FBrf0202435 Mutation induced by the mobilization of a P-element by the Delta2-3 transposase. The source of Delta2-3 is a stable genomic integration from which the third intron has been deleted. mutation induced by P-element mobilization by Delta2-3 transposase origin_of_mutation FBcv:0000488 Delta2-3 transposase FBcv:0000488 Mutation induced by the mobilization of a P-element by the Delta2-3 transposase. The source of Delta2-3 is a stable genomic integration from which the third intron has been deleted. FlyBase:FBrf0202435 Mutation caused by a P-element that is inserted into the genome and that is used to create more insertions at other sites. mutation induced by jumpstarter mobilization origin_of_mutation Js Jumpstarter FBcv:0000489 jumpstarter activity FBcv:0000489 Mutation caused by a P-element that is inserted into the genome and that is used to create more insertions at other sites. FlyBase:FBrf0202435 Mutation caused by the mobilization of a P-element by the transposase produced from the helper plasmid p pi25.1. This plasmid is a P-element from which the 3' terminus has been deleted, making it unable to integrate into the host's DNA. It is missing a 23 base pairs deletion of the 3' terminus compared to p pi25.1wc. mutation induced by P-element mobilization by p pi25.1 supplied transposase origin_of_mutation p pi25.1 FBcv:0000490 p pi25.1 supplied transposase FBcv:0000490 Mutation caused by the mobilization of a P-element by the transposase produced from the helper plasmid p pi25.1. This plasmid is a P-element from which the 3' terminus has been deleted, making it unable to integrate into the host's DNA. It is missing a 23 base pairs deletion of the 3' terminus compared to p pi25.1wc. FlyBase:FBrf0202435 Mutation caused by the mobilization of a P-element by the transposase produced from the helper plasmid p pi25.7wc. This plasmid is a P-element from which the 3' terminus has been deleted, making it unable to integrate into the host's DNA. It has an additional 23 base pairs deletion of the 3' terminus compared to p pi25.1. mutation induced by P-element mobilization by p pi25.7wc supplied transposase origin_of_mutation p pi25.7wc FBcv:0000491 p pi25.7wc FBcv:0000491 Mutation caused by the mobilization of a P-element by the transposase produced from the helper plasmid p pi25.7wc. This plasmid is a P-element from which the 3' terminus has been deleted, making it unable to integrate into the host's DNA. It has an additional 23 base pairs deletion of the 3' terminus compared to p pi25.1. FlyBase:FBrf0202435 Mutation caused by PM hybrid dysgenesis that is induced by the higher frequency of recombination in certain male chromosomes. mutation induced by male recombination origin_of_mutation MR FBcv:0000492 male recombination induced by dysgenesis FBcv:0000492 Mutation caused by PM hybrid dysgenesis that is induced by the higher frequency of recombination in certain male chromosomes. FlyBase:FBrf0202435 Mutation caused by a male recombination event induced by a male recombination factor which is present in chromosomes extracted from a population in Haifa, Israel. mutation induced by MRh12 male recombination origin_of_mutation MRh12 FBcv:0000493 MRh12 induced male recombination FBcv:0000493 Mutation caused by a male recombination event induced by a male recombination factor which is present in chromosomes extracted from a population in Haifa, Israel. FlyBase:FBrf0202435 Mutation caused by a male recombination event in the second and third chromosomes induced by a male recombination factor which is present in chromosomes extracted from a population in Harlingen, Texas. mutation induced by MRT007 male recombination origin_of_mutation MRT007 FBcv:0000494 MRT007 induced male recombination FBcv:0000494 Mutation caused by a male recombination event in the second and third chromosomes induced by a male recombination factor which is present in chromosomes extracted from a population in Harlingen, Texas. FlyBase:FBrf0202435 Mutation caused by a male recombination event induced by male recombination factor 23.5 MRF which is present in second chromosomes extracted from a population in Patras, Greece. 23.5 MRF mutation induced by MRF23.5 male recombination origin_of_mutation MRF23.5 FBcv:0000495 MRF23.5 induced male recombination FBcv:0000495 Mutation caused by a male recombination event induced by male recombination factor 23.5 MRF which is present in second chromosomes extracted from a population in Patras, Greece. FlyBase:FBrf0039984 FlyBase:FBrf0202435 23.5 MRF FlyBase:FBrf0039984 Mutation caused by a male recombination event induced by male recombination factor 31.1 MRF which is present in second chromosomes extracted from a population in Patras, Greece. 31.1 MRF mutation induced by MRF31.1 male recombination origin_of_mutation MRF31.1 FBcv:0000496 MRF31.1 induced male recombination FBcv:0000496 Mutation caused by a male recombination event induced by male recombination factor 31.1 MRF which is present in second chromosomes extracted from a population in Patras, Greece. FlyBase:FBrf0030109 FlyBase:FBrf0202435 31.1 MRF FlyBase:FBrf0030109 Mutation induced by the transposable activity caused by hobo, a DNA transposable element. The hobo element is 3.0 kilobases in length with 12 base pairs inverted terminal repeats. After mobilization by the hobo transposase and upon insertion it generates a flanking duplication of 8 base pairs at the target site upon insertion. mutation induced by hobo element activity origin_of_mutation FBcv:0000497 hobo activity FBcv:0000497 Mutation induced by the transposable activity caused by hobo, a DNA transposable element. The hobo element is 3.0 kilobases in length with 12 base pairs inverted terminal repeats. After mobilization by the hobo transposase and upon insertion it generates a flanking duplication of 8 base pairs at the target site upon insertion. FlyBase:FBrf0202435 Mutation caused by hybrid dysgenesis that results from the mobilization of the hobo element. mutation induced by hobo dysgenesis origin_of_mutation FBcv:0000498 hobo dysgenesis FBcv:0000498 Mutation caused by hybrid dysgenesis that results from the mobilization of the hobo element. FlyBase:FBrf0202435 Mutation caused by the activity of the hobo element, mobilized by an hobo transposase which is produced from the supplied P-element helper plasmid HBL1. mutation induced by Hobo transposase source HBL1 origin_of_mutation Hobbled1 Hobo transposase source FBcv:0000499 HBL1 supplied transposase FBcv:0000499 Mutation caused by the activity of the hobo element, mobilized by an hobo transposase which is produced from the supplied P-element helper plasmid HBL1. FlyBase:FBrf0202435 Mutation induced by the transposable activity caused by mariner, a DNA transposable element. The mariner element is 1.3 kilobases in length with 28 base pairs inverted terminal repeats. It specifically targets TA dinucleotides and generates a flanking duplication of these two bases upon insertion. Mobilization is induced by the activity of the mariner transposase. mutation induced by mariner activity origin_of_mutation FBcv:0000500 mariner activity FBcv:0000500 Mutation induced by the transposable activity caused by mariner, a DNA transposable element. The mariner element is 1.3 kilobases in length with 28 base pairs inverted terminal repeats. It specifically targets TA dinucleotides and generates a flanking duplication of these two bases upon insertion. Mobilization is induced by the activity of the mariner transposase. FlyBase:FBrf0202435 Mutation induced by transposable activity caused by the gypsy retrovirus. The gypsy element is a 7.5 kilobases in length with 482 base pairs terminal repeats. Mobilization is induced by the activity of the gypsy element transposase. mutation induced by gypsy element activity origin_of_mutation FBcv:0000501 gypsy element activity FBcv:0000501 Mutation induced by transposable activity caused by the gypsy retrovirus. The gypsy element is a 7.5 kilobases in length with 482 base pairs terminal repeats. Mobilization is induced by the activity of the gypsy element transposase. FlyBase:FBrf0202435 Mutation induced by the transposable activity caused by piggyBac, a DNA transposable element. The piggyBac is 2.5 kilobases in length with 13 base pairs inverted terminal repeats. It specifically targets TTAA dinucleotides and generates a flanking duplication of these 4 base pairs upon insertion. Mobilization is induced by the activity of the piggyBac transposase. mutation induced by piggyBac activity origin_of_mutation FBcv:0000502 piggyBac activity FBcv:0000502 Mutation induced by the transposable activity caused by piggyBac, a DNA transposable element. The piggyBac is 2.5 kilobases in length with 13 base pairs inverted terminal repeats. It specifically targets TTAA dinucleotides and generates a flanking duplication of these 4 base pairs upon insertion. Mobilization is induced by the activity of the piggyBac transposase. FlyBase:FBrf0202435 Mutation induced by exposure to radiation. mutation induced by irradiation origin_of_mutation FBcv:0000503 irradiation FBcv:0000503 Mutation induced by exposure to radiation. FBC:MMC Mutation induced by exposure to ionizing radiation. mutation induced by ionizing irradiation origin_of_mutation FBcv:0000504 ionizing radiation FBcv:0000504 Mutation induced by exposure to ionizing radiation. FBC:MMC Mutation induced by exposure to alpha rays. mutation induced by alpha ray irradiation origin_of_mutation FBcv:0000505 alpha ray FBcv:0000505 Mutation induced by exposure to alpha rays. FBC:MMC Mutation induced by exposure to gamma rays. mutation induced by gamma ray irradiation origin_of_mutation FBcv:0000506 gamma ray FBcv:0000506 Mutation induced by exposure to gamma rays. FBC:MMC Mutation induced by exposure to 60Co gamma rays. mutation induced by 60Co gamma ray irradiation origin_of_mutation FBcv:0000507 60Co gamma ray FBcv:0000507 Mutation induced by exposure to 60Co gamma rays. FBC:MMC Mutation induced by exposure to 137Cs gamma rays. mutation induced by 137Cs gamma ray irradiation origin_of_mutation FBcv:0000508 137Cs gamma ray FBcv:0000508 Mutation induced by exposure to 137Cs gamma rays. FBC:MMC Mutation induced by exposure to 226Ra alpha rays. mutation induced by 226Ra alpha ray irradiation origin_of_mutation radium FBcv:0000509 226Ra alpha ray FBcv:0000509 Mutation induced by exposure to 226Ra alpha rays. FBC:MMC The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days (from CHEBI). 32-phosphorous mutation induced by 32-P irradiation phosphorus-32 atom origin_of_mutation FBcv:0000510 32P FBcv:0000510 The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days (from CHEBI). CHEBI:37972 The radioactive isotope of hydrogen with relative atomic mass 3.016049 and half-life of 12.33 years (from Greek taurhoiotatauomicronsigma, third) (from CHEBI). hydrogen-3 mutation induced by 3H irradiation tritium atom origin_of_mutation FBcv:0000511 3H FBcv:0000511 The radioactive isotope of hydrogen with relative atomic mass 3.016049 and half-life of 12.33 years (from Greek taurhoiotatauomicronsigma, third) (from CHEBI). CHEBI:29238 Mutation induced by exposure to 3H-deoxycytidine radiation. mutation induced by 3H-deoxycytidine irradiation tritiated 2'-deoxycytidine tritiated deoxycytidine origin_of_mutation FBcv:0000512 3H-deoxycytidine FBcv:0000512 Mutation induced by exposure to 3H-deoxycytidine radiation. FBC:MMC Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis (from CHEBI). mutation induced by 3H-thymidine irradiation tritiated thymidine origin_of_mutation FBcv:0000513 3H-thymidine FBcv:0000513 Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis (from CHEBI). CHEBI:53526 Mutation induced by treatment in a Bevatron. mutation induced by Bevatron irradiation origin_of_mutation FBcv:0000514 Bevatron FBcv:0000514 Mutation induced by treatment in a Bevatron. FBC:MMC Mutation induced by exposure to deuteron radiation. mutation induced by deuteron irradiation origin_of_mutation FBcv:0000515 deuteron FBcv:0000515 Mutation induced by exposure to deuteron radiation. FBC:MMC Mutation induced by exposure to neutron radiation. mutation induced by neutron irradiation origin_of_mutation FBcv:0000516 neutron FBcv:0000516 Mutation induced by exposure to neutron radiation. FBC:MMC Mutation induced by exposure to 252Cf fission neutron radiation. mutation induced by 252Cf fission neutron irradiation origin_of_mutation FBcv:0000517 252Cf fission neutron FBcv:0000517 Mutation induced by exposure to 252Cf fission neutron radiation. FBC:MMC Mutation induced by exposure to X rays. mutation induced by X ray irradiation origin_of_mutation FBcv:0000518 X ray FBcv:0000518 Mutation induced by exposure to X rays. FBC:MMC Mutation induced by exposure to non-ionizing radiation. mutation induced by non-ionizing irradiation origin_of_mutation FBcv:0000519 non-ionizing radiation FBcv:0000519 Mutation induced by exposure to non-ionizing radiation. FBC:MMC Mutation induced by exposure to a magnetic field. mutation induced by magnetic field irradiation origin_of_mutation FBcv:0000520 magnetic field FBcv:0000520 Mutation induced by exposure to a magnetic field. FBC:MMC Mutation induced by exposure to radio waves. mutation induced by radio waves irradiation origin_of_mutation FBcv:0000521 radio waves FBcv:0000521 Mutation induced by exposure to radio waves. FBC:MMC Mutation induced by exposure to the stratosphere. mutation induced by stratosphere irradiation origin_of_mutation FBcv:0000522 stratosphere FBcv:0000522 Mutation induced by exposure to the stratosphere. FBC:MMC Mutation induced by exposure to supersonic radiation. mutation induced by supersonic irradiation origin_of_mutation FBcv:0000523 supersonic FBcv:0000523 Mutation induced by exposure to supersonic radiation. FBC:MMC Mutation induced by exposure to U.V. radiation. mutation induced by U.V. irradiation origin_of_mutation FBcv:0000524 U.V. FBcv:0000524 Mutation induced by exposure to U.V. radiation. FBC:MMC A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances (from CHEBI). mutation induced by chemical exposure origin_of_mutation FBcv:0000525 chemical FBcv:0000525 A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances (from CHEBI). CHEBI:24431 Any chemical (FBcv:0000525) that has role some alkylating agent (CHEBI:22333). mutation induced by alkylating agent exposure origin_of_mutation FBcv:0000526 alkylating agent FBcv:0000526 Any chemical (FBcv:0000525) that has role some alkylating agent (CHEBI:22333). CHEBI:22333 The diethyl ester of sulfuric acid (from CHEBI). mutation induced by diethyl sulfate exposure origin_of_mutation DES FBcv:0000527 diethyl sulfate FBcv:0000527 The diethyl ester of sulfuric acid (from CHEBI). CHEBI:34699 No definition for CHEBI:19508. mutation induced by 2-chloroethyl methanesulfonate exposure origin_of_mutation CB1506 FBcv:0000528 2-chloroethyl methanesulfonate FBcv:0000528 No definition for CHEBI:19508. CHEBI:19508 No definition for CHEBI:19579. mutation induced by 2-fluoroethyl methanesulfonate exposure origin_of_mutation CB1522 FBcv:0000529 2-fluoroethyl methanesulfonate FBcv:0000529 No definition for CHEBI:19579. CHEBI:19579 A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol (from CHEBI). mutation induced by EMS exposure mutation induced by ethyl methanesulfonate exposure origin_of_mutation CB1528 EMS FBcv:0000530 ethyl methanesulfonate FBcv:0000530 A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol (from CHEBI). CHEBI:23994 A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups (from CHEBI). mutation induced by ENU exposure mutation induced by ethyl nitrosourea exposure origin_of_mutation ENU N-ethyl-N-nitrosourea FBcv:0000531 ethyl nitrosourea FBcv:0000531 A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups (from CHEBI). CHEBI:23995 N-ethyl-N-nitrosourea CHEBI:23995 A methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel (from CHEBI). mutation induced by HMS exposure mutation induced by hycanthon methanesulfonate exposure origin_of_mutation HMS hycanthone mesylate FBcv:0000532 hycanthon methanesulfonate FBcv:0000532 A methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel (from CHEBI). CHEBI:24624 hycanthone mesylate CHEBI:24624 A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol (from CHEBI). mutation induced by MMS exposure mutation induced by methyl methanesulfonate exposure origin_of_mutation CB1540 MMS FBcv:0000533 methyl methanesulfonate FBcv:0000533 A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol (from CHEBI). CHEBI:25255 An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention (from CHEBI). FBcv:0000536 mutation induced by bis(2-chloroethyl) sulfide exposure mutation induced by mustard gas exposure mutation induced by sulfur gas exposure origin_of_mutation 1,1'-thiobis(2-chloroethane) CB1735 mustard gas sulfur mustard FBcv:0000534 bis(2-chloroethyl) sulfide FBcv:0000534 An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention (from CHEBI). CHEBI:25434 1,1'-thiobis(2-chloroethane) CHEBI:25434 mustard gas CHEBI:25434 sulfur mustard CHEBI:25434 An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position (from CHEBI). mutation induced by N-methyl-N'-nitro-N-nitrosoguanidine exposure origin_of_mutation MNNG NNG FBcv:0000535 N-methyl-N'-nitro-N-nitrosoguanidine FBcv:0000535 An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position (from CHEBI). CHEBI:21759 FBcv:0000536 true FlyBase miscellaneous CV FBcv:0000537 obsolete minos ammunition for transposable element mutagenesis true FBcv:0000537 No definition for CHEBI:13941. mutation induced by carbamate exposure origin_of_mutation FBcv:0000538 carbamate FBcv:0000538 No definition for CHEBI:13941. CHEBI:13941 A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages (from CHEBI). mutation induced by urethane exposure origin_of_mutation FBcv:0000539 urethane FBcv:0000539 A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages (from CHEBI). CHEBI:17967 No definition for CHEBI:27292. mutation induced by vinyl carbamate exposure origin_of_mutation FBcv:0000540 vinyl carbamate FBcv:0000540 No definition for CHEBI:27292. CHEBI:27292 Any chemical (FBcv:0000525) that has role some intercalator (CHEBI:24853). mutation induced by intercalating agent exposure origin_of_mutation FBcv:0000541 intercalating agent FBcv:0000541 Any chemical (FBcv:0000525) that has role some intercalator (CHEBI:24853). CHEBI:24853 No definition for CHEBI:27504. mutation induced by mitomycin C exposure origin_of_mutation FBcv:0000542 mitomycin C FBcv:0000542 No definition for CHEBI:27504. CHEBI:27504 No definition for CHEBI:37595. mutation induced by quinacrine mustard exposure origin_of_mutation 2-methoxy-6-[3-(ethyl-2-chloroethyl)aminopropylamino]acridine ICR 100 FBcv:0000543 Mapped to CHEBI on basis of synonym - quinacrine mustard. Originally primary name, ICR 100 is now relegated to a synonym. quinacrine mustard FBcv:0000543 No definition for CHEBI:37595. CHEBI:37595 ICR 100 CHEBI:37595 No definition for CHEBI:21183. mutation induced by ICR 170 exposure origin_of_mutation 2-methoxy-6-dichloro-9-(3-ethyl-2-chloroethyl-aminopropylamino)acridine-dihydrochloride FBcv:0000544 ICR 170 FBcv:0000544 No definition for CHEBI:21183. CHEBI:21183 A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae (from CHEBI). mutation induced by 1,2-dibromoethane exposure origin_of_mutation DBE FBcv:0000545 1,2-dibromoethane FBcv:0000545 A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae (from CHEBI). CHEBI:28534 A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2 (from CHEBI). mutation induced by 1,2-dichloroethane exposure origin_of_mutation DCE FBcv:0000546 1,2-dichloroethane FBcv:0000546 A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2 (from CHEBI). CHEBI:27789 A haloalkane that is bromoethane substituted by chlorine at position 2 (from CHEBI). mutation induced by 1-bromo-2-chloroethane exposure origin_of_mutation BCE FBcv:0000547 1-bromo-2-chloroethane FBcv:0000547 A haloalkane that is bromoethane substituted by chlorine at position 2 (from CHEBI). CHEBI:19032 A molecule that can substitute for a normal nucleobase in nucleic acids (from CHEBI). origin_of_mutation nucleobase analogue FBcv:0000548 base analog FBcv:0000548 A molecule that can substitute for a normal nucleobase in nucleic acids (from CHEBI). CHEBI:67142 nucleobase analogue CHEBI:67142 A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen (from CHEBI). mutation induced by 5-bromouracil exposure origin_of_mutation FBcv:0000549 5-bromouracil FBcv:0000549 A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen (from CHEBI). CHEBI:20552 A uridine having a bromo substituent at the 5-position (from CHEBI). mutation induced by 5-bromouridine exposure origin_of_mutation FBcv:0000550 5-bromouridine FBcv:0000550 A uridine having a bromo substituent at the 5-position (from CHEBI). CHEBI:20553 Any chemical (FBcv:0000525) that has role some enzyme inhibitor (CHEBI:23924). mutation induced by enzyme inhibitor exposure origin_of_mutation FBcv:0000551 enzyme inhibitor FBcv:0000551 Any chemical (FBcv:0000525) that has role some enzyme inhibitor (CHEBI:23924). CHEBI:23924 No definition for CHEBI:22526. mutation induced by aminopterin exposure origin_of_mutation FBcv:0000552 aminopterin FBcv:0000552 No definition for CHEBI:22526. CHEBI:22526 A molecular entity that contains no carbon (from CHEBI). inorganic molecular entity mutation induced by inorganic compound exposure origin_of_mutation FBcv:0000553 inorganic compound FBcv:0000553 A molecular entity that contains no carbon (from CHEBI). CHEBI:24835 inorganic molecular entity CHEBI:24835 A metal sulfate compound having copper(2+) as the metal ion (from CHEBI). mutation induced by cupric sulfate origin_of_mutation copper(2+) sulfate FBcv:0000554 cupric sulfate FBcv:0000554 A metal sulfate compound having copper(2+) as the metal ion (from CHEBI). CHEBI:23414 copper(2+) sulfate CHEBI:23414 No definition for CHEBI:33118. mutation induced by H3BO3 exposure origin_of_mutation FBcv:0000555 H3BO3 FBcv:0000555 No definition for CHEBI:33118. CHEBI:33118 An inorganic sodium salt having hydrogensulfite as the counterion (from CHEBI). mutation induced by sodium bisulphite exposure origin_of_mutation FBcv:0000556 sodium bisulphite FBcv:0000556 An inorganic sodium salt having hydrogensulfite as the counterion (from CHEBI). CHEBI:26709 A metal fluoride salt with a Na(+) counterion (from CHEBI). mutation induced by sodium fluoride exposure origin_of_mutation FBcv:0000557 sodium fluoride FBcv:0000557 A metal fluoride salt with a Na(+) counterion (from CHEBI). CHEBI:28741 Mutation induced by exposure to epoxy hydrocarbon. mutation induced by epoxy hydrocarbon exposure origin_of_mutation FBcv:0000558 epoxy hydrocarbon FBcv:0000558 Mutation induced by exposure to epoxy hydrocarbon. FBC:MMC No definition for CHEBI:23704. mutation induced by diepoxybutane exposure origin_of_mutation DEB erythritol anhydride FBcv:0000559 diepoxybutane FBcv:0000559 No definition for CHEBI:23704. CHEBI:23704 No definition for CHEBI:23705. mutation induced by diepoxyoctane exposure origin_of_mutation 1,2:7,8-diepoxyoctane FBcv:0000560 diepoxyoctane FBcv:0000560 No definition for CHEBI:23705. CHEBI:23705 1,2:7,8-diepoxyoctane CHEBI:23705 origin_of_mutation FBcv:0000561 obsolete unclassified chemical true FBcv:0000561 No definition for CHEBI:35299. mutation induced by 1,2:5,6-dibenzanthracene exposure origin_of_mutation FBcv:0000562 1,2:5,6-dibenzanthracene FBcv:0000562 No definition for CHEBI:35299. CHEBI:35299 A methanesulfonate ester that is hexane-2,5-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups (from CHEBI). mutation induced by 1,4-dimethanesulfonoxy-1,4-dimethylbutane exposure origin_of_mutation 1,4-dimethanesulfonoxy-1:4-dimethylbutane CB2348 dimethylmyleran FBcv:0000563 1,4-dimethanesulfonoxy-1,4-dimethylbutane FBcv:0000563 A methanesulfonate ester that is hexane-2,5-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups (from CHEBI). CHEBI:67107 dimethylmyleran CHEBI:67107 Mutation induced by exposure to 1,4-dimethanesulfonoxybut-2-yne. mutation induced by 1,4-dimethanesulfonoxybut-2-yne exposure origin_of_mutation CB2058 FBcv:0000564 1,4-dimethanesulfonoxybut-2-yne FBcv:0000564 Mutation induced by exposure to 1,4-dimethanesulfonoxybut-2-yne. FBC:MMC Dominance relationships describe the dependence of the expression of a phenotypic attribute of an allele on the genotype at the locus in question. An allele might be recessive with respect to one phenotypic attribute, but dominant with respect to another. dominance_qualifier FBcv:0000565 dominance relationship qualifier FBcv:0000565 Dominance relationships describe the dependence of the expression of a phenotypic attribute of an allele on the genotype at the locus in question. An allele might be recessive with respect to one phenotypic attribute, but dominant with respect to another. FBC:rd Mutation induced by exposure to 1,6-dimethylsulfonoxy D-mannitol. mutation induced by 1,6-dimethylsulfonoxy D-mannitol exposure origin_of_mutation CB2511 FBcv:0000566 1,6-dimethylsulfonoxy D-mannitol FBcv:0000566 Mutation induced by exposure to 1,6-dimethylsulfonoxy D-mannitol. FBC:MMC Mutation induced by exposure to 1,6-dimethylsulfonoxy L-mannitol. mutation induced by 1,6-dimethylsulfonoxy L-mannitol exposure origin_of_mutation CB2628 FBcv:0000567 1,6-dimethylsulfonoxy L-mannitol FBcv:0000567 Mutation induced by exposure to 1,6-dimethylsulfonoxy L-mannitol. FBC:MMC No definition for CHEBI:19024. mutation induced by 1-amino-2-naphthol-4-sulfonic acid exposure origin_of_mutation FBcv:0000568 1-amino-2-naphthol-4-sulfonic acid FBcv:0000568 No definition for CHEBI:19024. CHEBI:19024 A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone (from CHEBI). mutation induced by lucanthone exposure origin_of_mutation 1-diethylaminoethylethylamino-4-methyl-thioxanthenone 1-{[2-(diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one lucanthone FBcv:0000569 lucanthone FBcv:0000569 A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone (from CHEBI). CHEBI:51052 1-{[2-(diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one CHEBI:51052 lucanthone CHEBI:51052 A hydroxyether that is ethanol substituted by a methoxy group at position 2 (from CHEBI). mutation induced by 2-methoxyethanol exposure origin_of_mutation FBcv:0000570 2-methoxyethanol FBcv:0000570 A hydroxyether that is ethanol substituted by a methoxy group at position 2 (from CHEBI). CHEBI:46790 A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups (from CHEBI). mutation induced by 2,5-bis(ethyleneimino)-1,4-benzoquinone exposure origin_of_mutation 2,5,-bisethylene-imine-1,4-benzoquinone FBcv:0000571 2,5-bis(ethyleneimino)-1,4-benzoquinone FBcv:0000571 A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups (from CHEBI). CHEBI:19363 A member of the class of tetraphenes that is tetraphene in which the hydrogens at positions 7 and 12 are replaced by bromomethyl and methyl groups, respectively (from CHEBI). mutation induced by 7-bromomethyl-12-methylbenz[a]anthracene exposure origin_of_mutation 7-bromomethyl 12 methyl benzalpha anthracine 7-bromomethyl-12-methyltetraphene FBcv:0000572 7-bromomethyl-12-methylbenz[a]anthracene FBcv:0000572 A member of the class of tetraphenes that is tetraphene in which the hydrogens at positions 7 and 12 are replaced by bromomethyl and methyl groups, respectively (from CHEBI). CHEBI:20787 7-bromomethyl-12-methyltetraphene CHEBI:20787 No definition for CHEBI:27666. mutation induced by actinomycin D exposure origin_of_mutation FBcv:0000573 actinomycin D FBcv:0000573 No definition for CHEBI:27666. CHEBI:27666 An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings (from CHEBI). mutation induced by benzo(alpha)pyrene exposure origin_of_mutation benzo[a]pyrene FBcv:0000574 benzo(alpha)pyrene FBcv:0000574 An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings (from CHEBI). CHEBI:29865 benzo[a]pyrene CHEBI:29865 A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee (from CHEBI). mutation induced by caffeine exposure origin_of_mutation FBcv:0000575 caffeine FBcv:0000575 A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee (from CHEBI). CHEBI:27732 A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups) (from CHEBI). mutation induced by cisplatin exposure origin_of_mutation cis-dichlorodiammineplatinum(II) FBcv:0000576 cisplatin FBcv:0000576 A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups) (from CHEBI). CHEBI:27899 An alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum (from CHEBI). mutation induced by colchicine exposure origin_of_mutation FBcv:0000577 colchicine FBcv:0000577 An alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum (from CHEBI). CHEBI:23359 A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents (from CHEBI). mutation induced by dimethyl sulfoxide exposure origin_of_mutation FBcv:0000578 dimethyl sulfoxide FBcv:0000578 A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents (from CHEBI). CHEBI:28262 High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms (from CHEBI). mutation induced by DNA treatment origin_of_mutation FBcv:0000579 DNA FBcv:0000579 High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms (from CHEBI). CHEBI:16991 An ether in which the oxygen atom is linked to two ethyl groups (from CHEBI). mutation induced by ethyl ether exposure origin_of_mutation FBcv:0000580 ethyl ether FBcv:0000580 An ether in which the oxygen atom is linked to two ethyl groups (from CHEBI). CHEBI:35702 No definition for CHEBI:30969. mutation induced by ethylenimine exposure origin_of_mutation EI FBcv:0000581 ethylenimine FBcv:0000581 No definition for CHEBI:30969. CHEBI:30969 A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom (from CHEBI). mutation induced by ethylene oxide exposure origin_of_mutation ethylene oxide oxirane FBcv:0000582 ethylene oxide FBcv:0000582 A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom (from CHEBI). CHEBI:27561 ethylene oxide CHEBI:27561 oxirane CHEBI:27561 No definition for CHEBI:28954. mutation induced by fagaronine exposure origin_of_mutation FBcv:0000583 fagaronine FBcv:0000583 No definition for CHEBI:28954. CHEBI:28954 An aldehyde resulting from the formal oxidation of methanol (from CHEBI). mutation induced by formaldehyde exposure origin_of_mutation FBcv:0000584 formaldehyde FBcv:0000584 An aldehyde resulting from the formal oxidation of methanol (from CHEBI). CHEBI:16842 A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage (from CHEBI). mutation induced by hesperidine exposure origin_of_mutation hesperidin FBcv:0000585 hesperidine FBcv:0000585 A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage (from CHEBI). CHEBI:28775 hesperidin CHEBI:28775 No definition for CHEBI:24564. mutation induced by HMM exposure mutation induced by hexamethylmelamine exposure origin_of_mutation HMM altretamine FBcv:0000586 hexamethylmelamine FBcv:0000586 No definition for CHEBI:24564. CHEBI:24564 No definition for CHEBI:24565. mutation induced by HMPA exposure mutation induced by hexamethylphosphoramide exposure origin_of_mutation HMPA FBcv:0000587 hexamethylphosphoramide FBcv:0000587 No definition for CHEBI:24565. CHEBI:24565 Chemical element with atomic number 53 (from CHEBI). mutation induced by iodine exposure origin_of_mutation FBcv:0000588 iodine FBcv:0000588 Chemical element with atomic number 53 (from CHEBI). CHEBI:24859 No definition for CHEBI:21184. mutation induced by Janus green B exposure origin_of_mutation Janus green B chloride FBcv:0000589 Janus green B FBcv:0000589 No definition for CHEBI:21184. CHEBI:21184 Janus green B chloride CHEBI:21184 No definition for CHEBI:25234. mutation induced by methoxy diethylnitrosamine exposure origin_of_mutation 1-methoxy-N-nitrosodiethylamine FBcv:0000590 Mapped to CHEBI:25234 (1-methoxy-N-nitrosodiethylamine) based on synonym of nitrosodiethylamine being diethylnitrosamine and CHEBI:25234 being classified as a mutagen. methoxy diethylnitrosamine FBcv:0000590 No definition for CHEBI:25234. CHEBI:25234 1-methoxy-N-nitrosodiethylamine CHEBI:25234 Mutation induced by exposure to natural gas. mutation induced by natural gas exposure origin_of_mutation FBcv:0000591 natural gas FBcv:0000591 Mutation induced by exposure to natural gas. FBC:MMC A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups (from CHEBI). mutation induced by MNU exposure mutation induced by nitrosomethyl urea exposure origin_of_mutation MNU N-methyl-N-nitrosourea FBcv:0000592 nitrosomethyl urea FBcv:0000592 A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups (from CHEBI). CHEBI:50102 N-methyl-N-nitrosourea CHEBI:50102 No definition for CHEBI:35807. mutation induced by DMN exposure mutation induced by N-nitrosodimethylamine exposure origin_of_mutation DMN FBcv:0000593 N-nitrosodimethylamine FBcv:0000593 No definition for CHEBI:35807. CHEBI:35807 No definition for CHEBI:25813. mutation induced by p-N,N-di(2-chloroethyl)aminophenylvaleric acid exposure origin_of_mutation CB1356 FBcv:0000594 p-N,N-di(2-chloroethyl)aminophenylvaleric acid FBcv:0000594 No definition for CHEBI:25813. CHEBI:25813 No definition for CHEBI:25814. mutation induced by p-N,N-di-(2-chloroethyl)amino-D-phenylalanine exposure origin_of_mutation CB3026 FBcv:0000595 p-N,N-di-(2-chloroethyl)amino-D-phenylalanine FBcv:0000595 No definition for CHEBI:25814. CHEBI:25814 A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring (from CHEBI). mutation induced by melphalan exposure mutation induced by p-N,N-di-(2-chloroethyl)amino-DL-phenylalanine exposure origin_of_mutation CB3007 melphalan FBcv:0000596 p-N,N-di-(2-chloroethyl)amino-DL-phenylalanine FBcv:0000596 A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring (from CHEBI). CHEBI:28876 melphalan CHEBI:28876 No definition for CHEBI:25816. mutation induced by p-N,N-di-(2-chloroethyl)amino-L-phenylalanine exposure origin_of_mutation CB3025 FBcv:0000597 p-N,N-di-(2-chloroethyl)amino-L-phenylalanine FBcv:0000597 No definition for CHEBI:25816. CHEBI:25816 FlyBase miscellaneous CV FBcv:0000598 Consider - FBsv:0001009. obsolete dominant temperature-sensitive lethal balancer true FBcv:0000598 No definition for CHEBI:25818. mutation induced by p-N,N-di-(2-chloroethyl)aminophenylethylamine exposure origin_of_mutation CB3034 FBcv:0000599 p-N,N-di-(2-chloroethyl)aminophenylethylamine FBcv:0000599 No definition for CHEBI:25818. CHEBI:25818 No definition for CHEBI:25829. mutation induced by p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine exposure origin_of_mutation CB305 FBcv:0000600 p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine FBcv:0000600 No definition for CHEBI:25829. CHEBI:25829 No definition for CHEBI:26491. mutation induced by quinhydrone exposure origin_of_mutation FBcv:0000601 quinhydrone FBcv:0000601 No definition for CHEBI:26491. CHEBI:26491 No definition for CHEBI:22025. mutation induced by S-2-chloroethylcysteine exposure origin_of_mutation CB1592 FBcv:0000602 S-2-chloroethylcysteine FBcv:0000602 No definition for CHEBI:22025. CHEBI:22025 No definition for CHEBI:26800. mutation induced by styryl quinoline exposure origin_of_mutation CB3086 FBcv:0000603 styryl quinoline FBcv:0000603 No definition for CHEBI:26800. CHEBI:26800 A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups (from CHEBI). mutation induced by triaziquone exposure origin_of_mutation FBcv:0000604 triaziquone FBcv:0000604 A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups (from CHEBI). CHEBI:27090 No definition for CHEBI:27919. mutation induced by triethylenemelamine exposure origin_of_mutation CB1246 TEM tretamine FBcv:0000605 triethylenemelamine FBcv:0000605 No definition for CHEBI:27919. CHEBI:27919 tretamine CHEBI:27919 Assay method used to generate an allele. mode_of_assay FBcv:0000606 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete allele assay method true FBcv:0000606 Assay method used to generate an allele. FBC:MMC mode_of_assay FBcv:0000607 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete In transgenic Drosophila true FBcv:0000607 mode_of_assay FBcv:0000608 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete Whole-organism transient assay true FBcv:0000608 mode_of_assay FBcv:0000609 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete Drosophila cell culture true FBcv:0000609 mode_of_assay FBcv:0000610 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete In transgenic Drosophila (allele of one drosophilid species in genome of another drosophilid) true FBcv:0000610 mode_of_assay FBcv:0000611 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete Whole-organism transient assay (allele from one drosophilid species assayed in another drosophilid) true FBcv:0000611 mode_of_assay FBcv:0000612 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete In transgenic Drosophila (allele of foreign species in genome of drosophilid) true FBcv:0000612 mode_of_assay FBcv:0000613 This term has been obsoleted because it is no longer used and relevant. mc151005 obsolete Whole-organism transient assay (allele of foreign species assayed in drosophilid) true FBcv:0000613 FlyBase miscellaneous CV FBcv:0000614 Consider - FBsv:0000000. obsolete stock descriptor true FBcv:0000614 FlyBase miscellaneous CV FBcv:0000615 obsolete extracted wild-type chromosome true FBcv:0000615 FlyBase miscellaneous CV FBcv:0000616 I don't think this is a useful term. obsolete laboratory stock true FBcv:0000616 FlyBase miscellaneous CV FBcv:0000617 obsolete selected wild-type stock true FBcv:0000617 FlyBase miscellaneous CV FBcv:0000618 Consider - FBsv:0001005. obsolete wild-type stock true FBcv:0000618 FlyBase miscellaneous CV FBcv:0000619 Consider - FBsv:0001002. obsolete isogenic stock true FBcv:0000619 Qualifier that describes the relation between two phenotypes that are due to genotypes g1 and g2. genetic_interaction_type FBcv:0000620 genetic interaction qualifier FBcv:0000620 Qualifier that describes the relation between two phenotypes that are due to genotypes g1 and g2. FBC:MMC The genotype g1 is a suppressor of genotype g2 if (and only if) the phenotype due to g2 is made less severe by g1. genetic_interaction_type FBcv:0000621 Not used directly in curation, but automatically inferred from its inverse (suppressible). suppressor FBcv:0000621 The genotype g1 is a suppressor of genotype g2 if (and only if) the phenotype due to g2 is made less severe by g1. FBC:DOS FlyBase:FBrf0000957 ISBN:978-0-387-52054-4 A phenotype due to genotype g1 is suppressible by genotype g2 if the if the phenotype due to the genotype g1g2 is less severe than that due to g1 alone. genetic_interaction_type FBcv:0000622 suppressible FBcv:0000622 A phenotype due to genotype g1 is suppressible by genotype g2 if the if the phenotype due to the genotype g1g2 is less severe than that due to g1 alone. FBC:DOS FlyBase:FBrf0000957 ISBN:978-0-387-52054-4 Genotype g1 is enhancer of genotype g2 if (and only if) the phenotype due to the genotype g1g2 is more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions. genetic_interaction_type FBcv:0000623 Not used directly in curation, but automatically inferred from its inverse (enhanceable). enhancer FBcv:0000623 Genotype g1 is enhancer of genotype g2 if (and only if) the phenotype due to the genotype g1g2 is more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions. FBC:DOS FlyBase:FBrf0000957 ISBN:978-0-387-52054-4 A phenotype due to genotype g1 is enhanceable by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions. genetic_interaction_type FBcv:0000624 enhanceable FBcv:0000624 A phenotype due to genotype g1 is enhanceable by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions. FBC:DOS FlyBase:FBrf0000957 ISBN:978-0-387-52054-4 Genotype g1 is a non-enhancer of genotype g2 if (and only if) the phenotype due to the genotype g1g2 is not more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions. genetic_interaction_type FBcv:0000625 Not used directly in curation, but automatically inferred from its inverse (non-enhanceable). non-enhancer FBcv:0000625 Genotype g1 is a non-enhancer of genotype g2 if (and only if) the phenotype due to the genotype g1g2 is not more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions. FBC:MMC FlyBase:FBrf0000957 ISBN:978-0-387-52054-4 A phenotype due to genotype g1 is non-enhanceable by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is no more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions. genetic_interaction_type FBcv:0000626 non-enhanceable FBcv:0000626 A phenotype due to genotype g1 is non-enhanceable by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is no more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions. FBC:DOS FlyBase:FBrf0000957 ISBN:978-0-387-52054-4 The genotype g1 is a non-suppressor of genotype g2 if (and only if) the phenotype due to g2 is not made less severe by g1. genetic_interaction_type FBcv:0000627 Not used directly in curation, but automatically inferred from its inverse (non-suppressible). non-suppressor FBcv:0000627 The genotype g1 is a non-suppressor of genotype g2 if (and only if) the phenotype due to g2 is not made less severe by g1. FBC:MMC FlyBase:FBrf0000957 ISBN:978-0-387-52054-4 A phenotype due to genotype g1 is non-suppressible by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is no less severe than the phenotype due to g1 alone. genetic_interaction_type FBcv:0000628 non-suppressible FBcv:0000628 A phenotype due to genotype g1 is non-suppressible by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is no less severe than the phenotype due to g1 alone. FBC:DOS FlyBase:FBrf0000957 ISBN:978-0-387-52054-4 FlyBase miscellaneous CV FBcv:0000629 obsolete dominant temperature-sensitive lethal balancer for chromosome 2 true FBcv:0000629 FlyBase miscellaneous CV FBcv:0000630 obsolete dominant temperature-sensitive lethal balancer for chromosome 3 true FBcv:0000630 FlyBase miscellaneous CV FBcv:0000631 obsolete DrosDel Project deficiency core kit stock true FBcv:0000631 FlyBase miscellaneous CV FBcv:0000632 Consider - FBsv:0000601. obsolete Bloomington Stock Center deficiency kit stock true FBcv:0000632 FlyBase miscellaneous CV FBcv:0000633 obsolete Exelixis deficiency kit stock true FBcv:0000633 FlyBase miscellaneous CV FBcv:0000634 obsolete duplication kit stock true FBcv:0000634 FlyBase miscellaneous CV FBcv:0000635 Consider - FBsv:0000603. obsolete Cambridge 2 duplication kit stock true FBcv:0000635 FlyBase miscellaneous CV FBcv:0000636 Consider - FBsv:0000602. obsolete Bloomington duplication kit stock true FBcv:0000636 FlyBase miscellaneous CV FBcv:0000637 obsolete Gene Disruption Project stock true FBcv:0000637 FlyBase miscellaneous CV FBcv:0000638 Consider - FBsv:0001003. obsolete sequenced strain true FBcv:0000638 FlyBase miscellaneous CV FBcv:0000639 Consider - FBsv:0000604. obsolete Golic gene replacement kit stock true FBcv:0000639 FlyBase miscellaneous CV FBcv:0000640 obsolete Golic laboratory gene replacement kit stock true FBcv:0000640 FlyBase miscellaneous CV FBcv:0000641 obsolete stock by cytotype true FBcv:0000641 FlyBase miscellaneous CV FBcv:0000642 obsolete H cytotype stock true FBcv:0000642 FlyBase miscellaneous CV FBcv:0000643 obsolete hobo family transposable element insertions present true FBcv:0000643 FlyBase miscellaneous CV FBcv:0000644 obsolete hobo family transposable element insertions absent true FBcv:0000644 FlyBase miscellaneous CV FBcv:0000645 obsolete P cytotype stock true FBcv:0000645 FlyBase miscellaneous CV FBcv:0000646 obsolete P-element family transposable element insertions absent true FBcv:0000646 FlyBase miscellaneous CV FBcv:0000647 obsolete P-element family transposable element insertions present true FBcv:0000647 FlyBase miscellaneous CV FBcv:0000648 obsolete mapping stock true FBcv:0000648 FlyBase miscellaneous CV FBcv:0000649 obsolete visible allele recombination mapping stock true FBcv:0000649 Work consisting of a statement of the opinions, beliefs, and policy of the editor or publisher of a journal, usually on current matters of medical or scientific significance to the medical community or society at large. MeSH:D016421 pub_type FBcv:0000650 editorial FBcv:0000650 Work consisting of a statement of the opinions, beliefs, and policy of the editor or publisher of a journal, usually on current matters of medical or scientific significance to the medical community or society at large. MeSH:D016421 pub_type FBcv:0000651 This term was obsoleted to conform with the MeSH terms used by PubMed. Please use 'FBcv:0000199 obsolete meeting report true FBcv:0000651 A publication containing a collection of separate articles written by distinct authors. Parent publication multipub multipublication pub_type FBcv:0000652 compendium FBcv:0000652 A publication containing a collection of separate articles written by distinct authors. FBC:SM Parent publication FBC:SM multipub FBC:SM multipublication FBC:SM Restricted to unknown subtype(s) of a specified type. expression_qualifier FBcv:0000653 subset FBcv:0000653 Restricted to unknown subtype(s) of a specified type. FBC:DS Qualifier that describes the expression pattern of an embryo. embryonic_pattern_qualifier FBcv:0000654 embryonic pattern qualifier FBcv:0000654 Qualifier that describes the expression pattern of an embryo. FBC:MMC VDRC Vienna FlyBase miscellaneous CV FBcv:0000655 Consider - FBsv:0000107. obsolete Vienna Drosophila RNAi Center true FBcv:0000655 FlyBase miscellaneous CV FBcv:0000656 Consider - FBsv:0000008. obsolete frozen specimen true FBcv:0000656 FlyBase miscellaneous CV FBcv:0000657 obsolete mutant stock true FBcv:0000657 FlyBase miscellaneous CV FBcv:0000658 obsolete DrosDel Project deficiency stock true FBcv:0000658 FlyBase miscellaneous CV FBcv:0000659 obsolete deficiency stock true FBcv:0000659 FlyBase miscellaneous CV FBcv:0000660 Consider - FBsv:0000501. obsolete inbred line true FBcv:0000660 FlyBase miscellaneous CV FBcv:0000661 Consider - FBsv:0000502. obsolete isofemale line true FBcv:0000661 A stock established from flies collected in the wild within the past 3 years. FlyBase miscellaneous CV FBcv:0000662 Consider - FBsv:0000504. obsolete recently collected stock true FBcv:0000662 A stock established from flies collected in the wild within the past 3 years. FBC:KM FlyBase miscellaneous CV FBcv:0000663 obsolete transposable element-containing stock true FBcv:0000663 FlyBase miscellaneous CV FBcv:0000664 obsolete duplication stock true FBcv:0000664 Phenotype that is an abnormality in body size compared to wild-type animals raised under the same conditions as the animals exhibiting the phenotype. body size defective phenotypic_class FBcv:0000665 abnormal body size FBcv:0000665 Phenotype that is an abnormality in body size compared to wild-type animals raised under the same conditions as the animals exhibiting the phenotype. FBC:DOS pub_type FBcv:0000666 This term was obsoleted to conform with the MeSH terms used by PubMed. Please use 'FBcv:0000199 obsolete conference proceedings true FBcv:0000666 A set of related web pages containing content such as text, images, video, audio, etc., prepared and maintained as a collection of information on a particular subject. pub_type FBcv:0000667 website FBcv:0000667 A set of related web pages containing content such as text, images, video, audio, etc., prepared and maintained as a collection of information on a particular subject. FBC:SM Phenotype that is any abnormality in cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.' cell adhesion defective phenotypic_class FBcv:0000668 abnormal cell adhesion FBcv:0000668 Phenotype that is any abnormality in cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.' FBC:DOS GOC:hb GOC:pf Phenotype that is any abnormality in hatching behavior (GO:0035187). 'hatching behavior' is defined as: 'The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell.' hatching behavior defective hatching behaviour defective phenotypic_class FBcv:0000669 abnormal hatching behavior FBcv:0000669 Phenotype that is any abnormality in hatching behavior (GO:0035187). 'hatching behavior' is defined as: 'The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell.' FBC:DOS GOC:pr PMID:10436051 Phenotype that is any abnormality in eclosion (GO:0007562). 'eclosion' is defined as: 'The emergence of an adult insect from a pupa case.' eclosion defective phenotypic_class FBcv:0000670 abnormal eclosion FBcv:0000670 Phenotype that is any abnormality in eclosion (GO:0007562). 'eclosion' is defined as: 'The emergence of an adult insect from a pupa case.' FBC:DOS GOC:dgh GOC:dos GOC:mah ISBN:0198600461 Phenotype that is any abnormality in cell cycle (GO:0007049). 'cell cycle' is defined as: 'The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.' cell cycle defective phenotypic_class FBcv:0000671 abnormal cell cycle FBcv:0000671 Phenotype that is any abnormality in cell cycle (GO:0007049). 'cell cycle' is defined as: 'The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.' FBC:DOS GOC:go_curators GOC:mtg_cell_cycle Phenotype that is any abnormality in endomitotic cell cycle (GO:0007113). 'endomitotic cell cycle' is defined as: 'A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.' endocycle defective endomitotic cell cycle defective phenotypic_class FBcv:0000672 abnormal endomitotic cell cycle FBcv:0000672 Phenotype that is any abnormality in endomitotic cell cycle (GO:0007113). 'endomitotic cell cycle' is defined as: 'A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.' FBC:DOS GOC:curators GOC:dos GOC:expert_vm FlyBase miscellaneous CV FBcv:0000673 Consider - FBsv:0001003. obsolete sequenced whole genome stock true FBcv:0000673 FlyBase miscellaneous CV FBcv:0000674 obsolete phiC31 based integration system true FBcv:0000674 FlyBase miscellaneous CV FBcv:0000675 obsolete phiC31 docking site stock true FBcv:0000675 FlyBase miscellaneous CV FBcv:0000676 Consider - FBsv:0000503. obsolete multi-female collection true FBcv:0000676 60-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. 2009-05-28T03:54:39Z spatial_qualifier FBcv:0000677 60-70% egg length FBcv:0000677 60-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS 80-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. 2009-05-28T03:55:30Z spatial_qualifier FBcv:0000678 80-100% egg length FBcv:0000678 80-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo. FBC:DOS Phenotype that is any abnormality in circadian behavior (GO:0048512). 'circadian behavior' is defined as: 'The specific behavior of an organism that recurs with a regularity of approximately 24 hours.' 2009-11-30T11:06:35Z circadian behavior defective phenotypic_class FBcv:0000679 abnormal circadian behavior FBcv:0000679 Phenotype that is any abnormality in circadian behavior (GO:0048512). 'circadian behavior' is defined as: 'The specific behavior of an organism that recurs with a regularity of approximately 24 hours.' FBC:DOS GOC:bf GOC:go_curators GOC:pr Phenotype that is any abnormality in proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.' proboscis extension reflex defective phenotypic_class FBcv:0000680 abnormal proboscis extension reflex FBcv:0000680 Phenotype that is any abnormality in proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.' FB:FBrf0044924 FBC:DOS GOC:jid Phenotype that is any abnormality in sensory perception (GO:0007600). 'sensory perception' is defined as: 'The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.' 2010-02-23T12:28:26Z sensory perception defective phenotypic_class FBcv:0000681 abnormal sensory perception FBcv:0000681 Phenotype that is any abnormality in sensory perception (GO:0007600). 'sensory perception' is defined as: 'The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.' FBC:DOS GOC:ai GOC:dph Phenotype that is any abnormality in sensory perception of touch (GO:0050975). 'sensory perception of touch' is defined as: 'The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).' touch perception defective phenotypic_class FBcv:0000682 abnormal touch perception FBcv:0000682 Phenotype that is any abnormality in sensory perception of touch (GO:0050975). 'sensory perception of touch' is defined as: 'The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).' FBC:DOS GOC:ai Phenotype that is any abnormality in response to temperature stimulus (GO:0009266). 'response to temperature stimulus' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.' 2010-02-23T12:51:02Z temperature response defective phenotypic_class FBcv:0000683 abnormal temperature response FBcv:0000683 Phenotype that is any abnormality in response to temperature stimulus (GO:0009266). 'response to temperature stimulus' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.' FBC:DOS GOC:hb Phenotype that is any abnormality in response to cold (GO:0009409). 'response to cold' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.' 2010-02-23T02:11:27Z cold stress response defective phenotypic_class FBcv:0000684 abnormal cold stress response FBcv:0000684 Phenotype that is any abnormality in response to cold (GO:0009409). 'response to cold' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.' FBC:DOS GOC:lr Parental effects describe the dependence of the expression of a phenotypic attribute of an allele on the parent from which that allele is inherited. genotype_to_phenotype_relation FBcv:0000685 parental effect FBcv:0000685 Parental effects describe the dependence of the expression of a phenotypic attribute of an allele on the parent from which that allele is inherited. FBC:rd Phenotype that is any abnormality in axis specification (GO:0009798). 'axis specification' is defined as: 'The establishment, maintenance and elaboration of a pattern along a line or around a point.' axis specification defective phenotypic_class FBcv:0000686 This phenotypic class does not encompass planar polarity. abnormal axis specification FBcv:0000686 Phenotype that is any abnormality in axis specification (GO:0009798). 'axis specification' is defined as: 'The establishment, maintenance and elaboration of a pattern along a line or around a point.' FBC:DOS GOC:dph GOC:go_curators GOC:isa_complete Descriptor that relates to aspects of a balancer. FlyBase miscellaneous CV FBcv:0000687 balancer descriptor FBcv:0000687 Descriptor that relates to aspects of a balancer. FBC:MMC An allele that completely lacks function, coding either for a completely inactive gene product or none at all. 2010-09-06T03:57:21Z allele_class amorph null FBcv:0000688 amorphic allele FBcv:0000688 An allele that completely lacks function, coding either for a completely inactive gene product or none at all. FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele shown by molecular evidence to completely lack function, producing either a completely inactive gene product or none at all. 2010-09-06T03:57:49Z molecular null allele_class FBcv:0000689 amorphic allele - molecular evidence FBcv:0000689 An allele shown by molecular evidence to completely lack function, producing either a completely inactive gene product or none at all. FlyBase:FBrf0049147 Allele that makes a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. 2010-09-06T03:58:15Z hypomorph allele_class FBcv:0000690 hypomorphic allele FBcv:0000690 Allele that makes a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele shown by molecular evidence to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. 2010-09-06T03:59:31Z allele_class FBcv:0000691 hypomorphic allele - molecular evidence FBcv:0000691 An allele shown by molecular evidence to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. FlyBase:FBrf0049147 An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern compared to wild-type. 2010-09-06T04:01:04Z allele_class FBcv:0000692 neomorphic allele - molecular evidence FBcv:0000692 An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern compared to wild-type. FlyBase:FBrf0002371 FlyBase:FBrf0049147 Allele shown by molecular evidence to make either a functionally wild-type gene product at increased levels or a gene product with the same function as wild-type but with increased activity. 2010-09-06T04:01:04Z allele_class FBcv:0000693 hypermorphic allele - molecular evidence FBcv:0000693 Allele shown by molecular evidence to make either a functionally wild-type gene product at increased levels or a gene product with the same function as wild-type but with increased activity. FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product. 2010-09-06T04:01:04Z allele_class dominant negative FBcv:0000694 antimorphic allele - molecular evidence FBcv:0000694 An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product. FlyBase:FBrf0049147 An allele that makes a gene product that is antagonistic to the function of the wild-type gene product. 2010-09-06T04:02:05Z allele_class antimorph FBcv:0000695 antimorphic allele FBcv:0000695 An allele that makes a gene product that is antagonistic to the function of the wild-type gene product. FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that makes either increased amounts of a normal gene product or a gene product with normal function but increased activity compared to wild-type. 2010-09-06T04:02:45Z allele_class hypermorph FBcv:0000696 hypermorphic allele FBcv:0000696 An allele that makes either increased amounts of a normal gene product or a gene product with normal function but increased activity compared to wild-type. FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that makes a gene product with a novel function or expression pattern compared to wild-type. 2010-09-06T04:03:33Z allele_class neomorph FBcv:0000697 neomorphic allele FBcv:0000697 An allele that makes a gene product with a novel function or expression pattern compared to wild-type. FlyBase:FBrf0002371 FlyBase:FBrf0049147 A phenotype that is a disruption in the wild-type pattern of segments or parasegments of the embryo or larva. phenotypic_class FBcv:0000698 Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns. embryonic/larval segmentation phenotype FBcv:0000698 A phenotype that is a disruption in the wild-type pattern of segments or parasegments of the embryo or larva. FlyBase:FBrf0035438 Embryonic/larval segmentation phenotype that is the complete or partial loss of alternate segments or parasegments. phenotypic_class FBcv:0000699 Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns. pair rule phenotype FBcv:0000699 Embryonic/larval segmentation phenotype that is the complete or partial loss of alternate segments or parasegments. FlyBase:FBrf0035438 Embryonic/larval segmentation phenotype that is the complete or partial loss of even segments. phenotypic_class FBcv:0000700 Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns. even pair-rule phenotype FBcv:0000700 Embryonic/larval segmentation phenotype that is the complete or partial loss of even segments. FlyBase:FBrf0035438 Embryonic/larval segmentation phenotype that is the complete or partial loss of odd segments. phenotypic_class FBcv:0000701 Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns. odd pair-rule phenotype FBcv:0000701 Embryonic/larval segmentation phenotype that is the complete or partial loss of odd segments. FlyBase:FBrf0035438 Embryonic/larval segmentation phenotype in which some fraction of each segment (along the anterior-posterior axis) is deleted and replaced by a mirror image duplication of the remaining part of the segment. phenotypic_class FBcv:0000702 Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns. segment polarity phenotype FBcv:0000702 Embryonic/larval segmentation phenotype in which some fraction of each segment (along the anterior-posterior axis) is deleted and replaced by a mirror image duplication of the remaining part of the segment. FlyBase:FBrf0035438 Embryonic/larval segmentation phenotype that is the complete loss of a contiguous stretch of 2 or more segments. phenotypic_class FBcv:0000703 Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns. gap phenotype FBcv:0000703 Embryonic/larval segmentation phenotype that is the complete loss of a contiguous stretch of 2 or more segments. FlyBase:FBrf0035438 Phenotype expressed only in the presence or absence of some specific chemical whose presence or absence does not induce the same defect in wild-type animals. 2010-09-20T11:13:19Z environmental_qualifier FBcv:0000704 chemical conditional FBcv:0000704 Phenotype expressed only in the presence or absence of some specific chemical whose presence or absence does not induce the same defect in wild-type animals. FBC:DOS Phenotype that is any abnormality in sleep (GO:0030431). 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.' 2010-09-20T12:06:13Z sleep defective phenotypic_class FBcv:0000705 abnormal sleep FBcv:0000705 Phenotype that is any abnormality in sleep (GO:0030431). 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.' FBC:DOS ISBN:0192800981 Phenotype that is any abnormality in entry into diapause (GO:0055115). 'entry into diapause' is defined as: 'The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation.' 2010-09-20T12:06:28Z diapause defective phenotypic_class FBcv:0000706 abnormal diapause FBcv:0000706 Phenotype that is any abnormality in entry into diapause (GO:0055115). 'entry into diapause' is defined as: 'The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation.' FBC:DOS GOC:ds GOC:jid GOC:mah Phenotype that is any abnormality in entry into reproductive diapause (GO:0055116). 'entry into reproductive diapause' is defined as: 'The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli.' 2010-09-20T12:21:29Z reproductive diapause defective phenotypic_class FBcv:0000707 abnormal reproductive diapause FBcv:0000707 Phenotype that is any abnormality in entry into reproductive diapause (GO:0055116). 'entry into reproductive diapause' is defined as: 'The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli.' FBC:DOS GOC:ds GOC:jid GOC:mah Phenotype that is any abnormality in response to starvation (GO:0042594). 'response to starvation' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.' starvation stress response defective phenotypic_class FBcv:0000708 abnormal starvation stress response FBcv:0000708 Phenotype that is any abnormality in response to starvation (GO:0042594). 'response to starvation' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.' FBC:DOS GOC:go_curators Phenotype that is an increase or decrease in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by defects in cell growth - there may be a greater or lesser number of cells in an otherwise normal volume of tissue. cell number defective phenotypic_class FBcv:0000709 abnormal cell number FBcv:0000709 Phenotype that is an increase or decrease in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by defects in cell growth - there may be a greater or lesser number of cells in an otherwise normal volume of tissue. FBC:DOS Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double stranded break in an engineered donor construct that contains sequence homologous to the target gene. change induced by gene targeting via homologous recombination origin_of_mutation FBcv:0000710 Strictly, homologous recombinational repair (GO:0000724) defines only the endogenous process, not its use for engineered gene targeting. gene targeting by homologous recombination FBcv:0000710 Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double stranded break in an engineered donor construct that contains sequence homologous to the target gene. FBC:MC FlyBase:FBrf0202435 Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double strand break on both sides of the homologous region in an engineered donor sequence. This double-strand break is usually generated by cutting at a single site adjacent to the homologous region in a circularized donor sequence. This typically generates a simple targeted replacement of the target sequence by the donor sequence. However, more complicated outcomes are possible. change induced by ends-out gene targeting origin_of_mutation FBcv:0000711 ends-out gene targeting FBcv:0000711 Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double strand break on both sides of the homologous region in an engineered donor sequence. This double-strand break is usually generated by cutting at a single site adjacent to the homologous region in a circularized donor sequence. This typically generates a simple targeted replacement of the target sequence by the donor sequence. However, more complicated outcomes are possible. FBC:MC FlyBase:FBrf0167363 FlyBase:FBrf0202435 Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double strand break within an engineered homologous donor sequence. This typically generates a tandem duplication of the homologous sequence from the donor, separated by the remainder of the incoming donor DNA. However, more complicated outcomes are possible. change induced by ends-in gene targeting origin_of_mutation FBcv:0000712 ends-in gene targeting FBcv:0000712 Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double strand break within an engineered homologous donor sequence. This typically generates a tandem duplication of the homologous sequence from the donor, separated by the remainder of the incoming donor DNA. However, more complicated outcomes are possible. FBC:MC FlyBase:FBrf0167363 FlyBase:FBrf0202435 Phenotype that is a inability to jump. This may be due to neurological or muscular defects. 2011-03-10T04:57:06Z phenotypic_class FBcv:0000713 jumpless FBcv:0000713 Phenotype that is a inability to jump. This may be due to neurological or muscular defects. FBC:DOS Phenotype only expressed under some specific nutritional regime. 2011-01-14T12:34:01Z environmental_qualifier FBcv:0000714 nutrition conditional FBcv:0000714 Phenotype only expressed under some specific nutritional regime. FBC:DOS Phenotype only expressed under conditions where calorie intake is restricted. 2011-01-14T05:12:37Z environmental_qualifier FBcv:0000715 calorie restriction conditional FBcv:0000715 Phenotype only expressed under conditions where calorie intake is restricted. FBC:DOS Phenotype that is any abnormality in cell migration (GO:0016477). 'cell migration' is defined as: 'The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.' cell migration defective phenotypic_class FBcv:0000716 abnormal cell migration FBcv:0000716 Phenotype that is any abnormality in cell migration (GO:0016477). 'cell migration' is defined as: 'The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.' FBC:DOS GOC:cjm GOC:dph GOC:ems GOC:pf Wikipedia:Cell_migration Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of cell growth (GO:0016049) in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. phenotypic_class FBcv:0000717 increased cell growth rate FBcv:0000717 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of cell growth (GO:0016049) in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. FBC:DOS Phenotype that is an decrease in any kind of rate (e.g. speed, frequency) of cell growth (GO:0016049) in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. reduced cell growth rate phenotypic_class FBcv:0000718 decreased cell growth rate FBcv:0000718 Phenotype that is an decrease in any kind of rate (e.g. speed, frequency) of cell growth (GO:0016049) in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. FBC:DOS Phenotype that is a decrease in size of an initially normally sized organ or tissue due to wasting away of cells. 2011-03-10T05:59:04Z phenotypic_class FBcv:0000719 atrophy FBcv:0000719 Phenotype that is a decrease in size of an initially normally sized organ or tissue due to wasting away of cells. FBC:DOS Phenotype that is any abnormality or in or absence of a jump response (GO:0007630). The jump response in Drosophila is a reflex escape response that can be triggered by a number of signals including odor and light. Standard assays are commonly used to test odor and light induced jump response. 2011-03-11T08:03:28Z jump response defective phenotypic_class FBcv:0000720 abnormal jump response FBcv:0000720 Phenotype that is any abnormality or in or absence of a jump response (GO:0007630). The jump response in Drosophila is a reflex escape response that can be triggered by a number of signals including odor and light. Standard assays are commonly used to test odor and light induced jump response. FlyBase:FBrf0187887 FlyBase:FBrf0191819 Phenotype that is any abnormality in mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.' mating behavior defective phenotypic_class FBcv:0000721 abnormal mating behavior FBcv:0000721 Phenotype that is any abnormality in mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.' FBC:DOS GOC:ai GOC:dph A clone of somatic cells that share a mutant genotype that includes being Minute +/+ and that is part of and derived from an animal with a different genotype that includes being Minute +/-. 2011-01-27T04:55:28Z clone_qualifier FBcv:0000722 somatic clone - Minute background FBcv:0000722 A clone of somatic cells that share a mutant genotype that includes being Minute +/+ and that is part of and derived from an animal with a different genotype that includes being Minute +/-. FBC:DOS Phenotype that consists of abnormal growth of a tissue or organ due to increased numbers of cells, but in which the affected tissue or organ does not maintain its normal form. neoplasm neoplastic tumorigenesis tumorigenic phenotypic_class FBcv:0000723 neoplasia FBcv:0000723 Phenotype that consists of abnormal growth of a tissue or organ due to increased numbers of cells, but in which the affected tissue or organ does not maintain its normal form. FBC:DOS Phenotype that is a reduction in size of an organ or tissue compared to wild-type due to reduced numbers of cells being produced during its development or growth. phenotypic_class FBcv:0000724 This term should not be used where an organ or tissue is reduced in size due to the wasting away of existing cells. hypoplasia FBcv:0000724 Phenotype that is a reduction in size of an organ or tissue compared to wild-type due to reduced numbers of cells being produced during its development or growth. FBC:DOS Phenotype that is any abnormality in response to oxidative stress (GO:0006979). 'response to oxidative stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.' oxidative stress response defective phenotypic_class FBcv:0000725 abnormal oxidative stress response FBcv:0000725 Phenotype that is any abnormality in response to oxidative stress (GO:0006979). 'response to oxidative stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.' FBC:DOS GOC:jl PMID:12115731 Expressed in virgin females. 2011-04-21T01:10:32Z sex_qualifier FBcv:0000726 May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in virgin females. virgin female FBcv:0000726 Expressed in virgin females. FBC:DOS Expressed in mated females. 2011-04-21T01:10:49Z sex_qualifier FBcv:0000727 May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in mated females. mated female FBcv:0000727 Expressed in mated females. FBC:DOS Expressed in virgin males. 2011-04-21T01:11:13Z sex_qualifier FBcv:0000728 May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in virgin males. virgin male FBcv:0000728 Expressed in virgin males. FBC:DOS Expressed in mated males. 2011-04-21T01:11:21Z sex_qualifier FBcv:0000729 May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in mated females. mated male FBcv:0000729 Expressed in mated males. FBC:DOS Expression is limited to virgin females. 2011-04-21T01:11:46Z sex_qualifier FBcv:0000730 May be used to qualify expression of phenotypes or of genes, transgenes etc. virgin female limited FBcv:0000730 Expression is limited to virgin females. FBC:DOS Expression is limited to mated females. 2011-04-21T01:11:59Z sex_qualifier FBcv:0000731 May be used to qualify expression of phenotypes or of genes, transgenes etc. mated female limited FBcv:0000731 Expression is limited to mated females. FBC:DOS Expression is limited to mated males. 2011-04-21T01:12:14Z sex_qualifier FBcv:0000732 May be used to qualify expression of phenotypes or of genes, transgenes etc. mated male limited FBcv:0000732 Expression is limited to mated males. FBC:DOS Expression is limited to virgin males. 2011-04-21T01:13:00Z sex_qualifier FBcv:0000733 May be used to qualify expression of phenotypes or of genes, transgenes etc. virgin male limited FBcv:0000733 Expression is limited to virgin males. FBC:DOS Embryonic/larval segmentation phenotype that is the complete or partial loss of terminal regions of the embryo/larva: the acron, telson and immediately adjacent segments. 2011-09-13T02:31:53Z phenotypic_class FBcv:0000734 terminal phenotype FBcv:0000734 Embryonic/larval segmentation phenotype that is the complete or partial loss of terminal regions of the embryo/larva: the acron, telson and immediately adjacent segments. FBC:DOS A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom (from CHEBI). mutation induced by N-nitrosodiethylamine exposure origin_of_mutation NDEA FBcv:0000735 N-nitrosodiethylamine FBcv:0000735 A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom (from CHEBI). CHEBI:34873 NDEA FlyBase:FBrf0139766 An allele that completely lacks function (i.e. whose gene productive is completely inactive) at high temperatures, but that retains at least some function at lower temperatures. 2012-03-22T03:54:34Z allele_class FBcv:0000736 heat sensitive amorphic allele FBcv:0000736 An allele that completely lacks function (i.e. whose gene productive is completely inactive) at high temperatures, but that retains at least some function at lower temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred to completely lack function at some temperatures (restrictive temperatures) but not others (permissive temperatures) from the observation that addition of extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy). 2012-03-22T03:55:17Z allele_class FBcv:0000737 temperature conditional amorphic allele - genetic evidence FBcv:0000737 An allele inferred to completely lack function at some temperatures (restrictive temperatures) but not others (permissive temperatures) from the observation that addition of extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy). FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 A publication that is not issued on a regular, ongoing basis containing separate articles or chapters (typically reviews) written by different authors on a single subject or related subjects, overseen by one or more editors. 2012-07-10T04:05:08Z pub_type FBcv:0000738 edited book FBcv:0000738 A publication that is not issued on a regular, ongoing basis containing separate articles or chapters (typically reviews) written by different authors on a single subject or related subjects, overseen by one or more editors. FBC:SM An allele that completely lacks function (i.e. whose gene productive is completely inactive) at some temperatures, but not others. 2012-03-22T03:57:02Z allele_class FBcv:0000739 temperature conditional amorphic allele FBcv:0000739 An allele that completely lacks function (i.e. whose gene productive is completely inactive) at some temperatures, but not others. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred to completely lack function at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures) from the observation that adding extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy). 2012-03-22T03:58:31Z allele_class FBcv:0000740 cold sensitive amorphic allele - genetic evidence FBcv:0000740 An allele inferred to completely lack function at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures) from the observation that adding extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy). FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred to completely lack function at high temperatures (restrictive temperatures) but not at low temperatures (permissive temperatures) from the observation that adding extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy). 2012-03-22T03:59:43Z allele_class FBcv:0000741 heat sensitive amorphic allele - genetic evidence FBcv:0000741 An allele inferred to completely lack function at high temperatures (restrictive temperatures) but not at low temperatures (permissive temperatures) from the observation that adding extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy). FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele shown by molecular evidence to completely lack function at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures). 2012-03-22T03:58:31Z allele_class FBcv:0000742 cold sensitive amorphic allele - molecular evidence FBcv:0000742 An allele shown by molecular evidence to completely lack function at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures). FBC:DOS FlyBase:FBrf0049147 An allele shown by molecular evidence to completely lack function at high temperatures (restrictive temperatures) but not at low temperatures (permissive temperatures). 2012-03-22T03:59:43Z allele_class FBcv:0000743 heat sensitive amorphic allele - molecular evidence FBcv:0000743 An allele shown by molecular evidence to completely lack function at high temperatures (restrictive temperatures) but not at low temperatures (permissive temperatures). FBC:DOS FlyBase:FBrf0049147 An allele shown by molecular evidence to completely lack function at some temperatures (restrictive temperatures) but not at others (permissive temperatures). 2012-03-22T03:55:17Z allele_class FBcv:0000744 temperature conditional amorphic allele - molecular evidence FBcv:0000744 An allele shown by molecular evidence to completely lack function at some temperatures (restrictive temperatures) but not at others (permissive temperatures). FBC:DOS FlyBase:FBrf0049147 An allele that at some temperatures but not others either makes no functional gene product or makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type. 2012-03-22T03:57:02Z allele_class FBcv:0000745 temperature conditional loss of function allele FBcv:0000745 An allele that at some temperatures but not others either makes no functional gene product or makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type. FBC:DOS FlyBase:FBrf0049147 An allele that at high temperatures but not low temperatures, either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type. 2012-03-22T03:54:34Z allele_class FBcv:0000746 heat sensitive loss of function allele FBcv:0000746 An allele that at high temperatures but not low temperatures, either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type. FBC:DOS FlyBase:FBrf0049147 An allele that at low temperatures but not high temperatures, either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type. allele_class FBcv:0000747 cold sensitive loss of function allele FBcv:0000747 An allele that at low temperatures but not high temperatures, either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type. FBC:DOS FlyBase:FBrf0049147 An allele that at some temperatures but not others, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type. 2012-03-22T03:57:02Z allele_class FBcv:0000748 temperature conditional gain of function allele FBcv:0000748 An allele that at some temperatures but not others, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type. FBC:DOS FlyBase:FBrf0049147 An allele that at high temperatures but not low temperatures, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type. 2012-03-22T03:54:34Z allele_class FBcv:0000749 heat sensitive gain of function allele FBcv:0000749 An allele that at high temperatures but not low temperatures, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type. FBC:DOS FlyBase:FBrf0049147 An allele that at low temperatures but not high temperatures, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type. allele_class FBcv:0000750 cold sensitive gain of function allele FBcv:0000750 An allele that at low temperatures but not high temperatures, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type. FBC:DOS FlyBase:FBrf0049147 An allele that, at some temperatures but not others, makes a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. 2012-03-22T03:57:02Z allele_class FBcv:0000751 temperature conditional hypomorphic allele FBcv:0000751 An allele that, at some temperatures but not others, makes a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that makes a gene product that is functionally equivalent to wild-type but which at high temperatures is present in a lesser amount or with lowered activity, and that retains normal levels of expression or activity at low temperatures. 2012-03-22T03:54:34Z allele_class FBcv:0000752 heat sensitive hypomorphic allele FBcv:0000752 An allele that makes a gene product that is functionally equivalent to wild-type but which at high temperatures is present in a lesser amount or with lowered activity, and that retains normal levels of expression or activity at low temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that makes a gene product that is functionally equivalent to wild-type but which at low temperatures is present in a lesser amount or with lowered activity, and that retains normal function at higher temperatures. allele_class FBcv:0000753 cold sensitive hypomorphic allele FBcv:0000753 An allele that makes a gene product that is functionally equivalent to wild-type but which at low temperatures is present in a lesser amount or with lowered activity, and that retains normal function at higher temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred from genetic evidence to have normal activity at some temperatures (permissive temperatures) but at other temperatures to make a gene product with normal function but in a lesser amount or with lowered activity (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy)). 2012-03-22T03:55:17Z allele_class FBcv:0000754 temperature conditional hypomorphic allele - genetic evidence FBcv:0000754 An allele inferred from genetic evidence to have normal activity at some temperatures (permissive temperatures) but at other temperatures to make a gene product with normal function but in a lesser amount or with lowered activity (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy)). FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred from genetic evidence to have normal activity at high temperatures (permissive temperatures) but to make a gene product with normal function but in a lesser amount or with lowered activity at lower temperatures (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy)). 2012-03-22T03:58:31Z allele_class FBcv:0000755 cold sensitive hypomorphic allele - genetic evidence FBcv:0000755 An allele inferred from genetic evidence to have normal activity at high temperatures (permissive temperatures) but to make a gene product with normal function but in a lesser amount or with lowered activity at lower temperatures (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy)). FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred from genetic evidence to have normal activity at low temperatures (permissive temperatures) but to make a gene product with normal function but in a lesser amount or with lowered activity at higher temperatures (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy)). 2012-03-22T03:59:43Z allele_class FBcv:0000756 heat sensitive hypomorphic allele - genetic evidence FBcv:0000756 An allele inferred from genetic evidence to have normal activity at low temperatures (permissive temperatures) but to make a gene product with normal function but in a lesser amount or with lowered activity at higher temperatures (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy)). FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele shown by molecular evidence to make a normal gene product in normal amounts at some temperatures, but at other temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. 2012-03-22T03:55:17Z allele_class FBcv:0000757 temperature conditional hypomorphic allele - molecular evidence FBcv:0000757 An allele shown by molecular evidence to make a normal gene product in normal amounts at some temperatures, but at other temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. FBC:DOS FlyBase:FBrf0049147 An allele shown by molecular evidence to make a normal gene product in normal amounts at high temperatures, but at lower temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. 2012-03-22T03:58:31Z allele_class FBcv:0000758 cold sensitive hypomorphic allele - molecular evidence FBcv:0000758 An allele shown by molecular evidence to make a normal gene product in normal amounts at high temperatures, but at lower temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. FBC:DOS FlyBase:FBrf0049147 An allele shown by molecular evidence to make a normal gene product in normal amounts at low temperatures, but at higher temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. 2012-03-22T03:59:43Z allele_class FBcv:0000759 heat sensitive hypomorphic allele - molecular evidence FBcv:0000759 An allele shown by molecular evidence to make a normal gene product in normal amounts at low temperatures, but at higher temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity. FBC:DOS FlyBase:FBrf0049147 An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at some temperatures, but not others. 2012-03-22T03:57:02Z allele_class FBcv:0000760 temperature conditional antimorphic allele FBcv:0000760 An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at some temperatures, but not others. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at high temperatures, but not at lower temperatures. 2012-03-22T03:54:34Z allele_class FBcv:0000761 heat sensitive antimorphic allele FBcv:0000761 An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at high temperatures, but not at lower temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at cold temperatures, but not at higher temperatures. allele_class FBcv:0000762 cold sensitive antimorphic allele FBcv:0000762 An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at cold temperatures, but not at higher temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred to make a gene product that is antagonistic to the wild-type gene product at some temperatures (restrictive temperatures) but not at others (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. 2012-03-22T03:55:17Z allele_class FBcv:0000763 temperature conditional antimorphic allele - genetic evidence FBcv:0000763 An allele inferred to make a gene product that is antagonistic to the wild-type gene product at some temperatures (restrictive temperatures) but not at others (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred to make a gene product that is antagonistic to the wild-type gene product at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. 2012-03-22T03:58:31Z allele_class FBcv:0000764 cold sensitive antimorphic allele - genetic evidence FBcv:0000764 An allele inferred to make a gene product that is antagonistic to the wild-type gene product at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred to make a gene product that is antagonistic to the wild-type gene product at high temperatures (restrictive temperatures) but not at lower temperatures (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. 2012-03-22T03:59:43Z allele_class FBcv:0000765 heat sensitive antimorphic allele - genetic evidence FBcv:0000765 An allele inferred to make a gene product that is antagonistic to the wild-type gene product at high temperatures (restrictive temperatures) but not at lower temperatures (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at some temperatures but not others. 2012-03-22T03:55:17Z allele_class FBcv:0000766 temperature conditional antimorphic allele - molecular evidence FBcv:0000766 An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at some temperatures but not others. FBC:DOS FlyBase:FBrf0049147 An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at low temperatures but not higher temperatures. 2012-03-22T03:58:31Z allele_class FBcv:0000767 cold sensitive antimorphic allele - molecular evidence FBcv:0000767 An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at low temperatures but not higher temperatures. FBC:DOS FlyBase:FBrf0049147 An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at high temperatures but not lower temperatures. 2012-03-22T03:59:43Z allele_class FBcv:0000768 heat sensitive antimorphic allele - molecular evidence FBcv:0000768 An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at high temperatures but not lower temperatures. FBC:DOS FlyBase:FBrf0049147 An allele that, at some temperatures but not others, makes a gene product with a novel function or expression pattern compared to wild-type. 2012-03-22T03:57:02Z allele_class FBcv:0000769 temperature conditional neomorphic allele FBcv:0000769 An allele that, at some temperatures but not others, makes a gene product with a novel function or expression pattern compared to wild-type. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that, at some high temperatures but not lower temperatures, makes a gene product with a novel function or expression pattern compared to wild-type. 2012-03-22T03:54:34Z allele_class FBcv:0000770 heat sensitive neomorphic allele FBcv:0000770 An allele that, at some high temperatures but not lower temperatures, makes a gene product with a novel function or expression pattern compared to wild-type. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that, at some low temperatures but not higher temperatures, makes a gene product at with a novel function or expression pattern compared to wild-type. allele_class FBcv:0000771 cold sensitive neomorphic allele FBcv:0000771 An allele that, at some low temperatures but not higher temperatures, makes a gene product at with a novel function or expression pattern compared to wild-type. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some temperatures (non-permissive temperatures) but not others (permissive temperatures) based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene. 2012-03-22T03:55:17Z allele_class FBcv:0000772 temperature conditional neomorphic allele - genetic evidence FBcv:0000772 An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some temperatures (non-permissive temperatures) but not others (permissive temperatures) based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some low temperatures (non-permissive temperatures) but not higher temperatures (permissive temperatures), based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene. 2012-03-22T03:58:31Z allele_class FBcv:0000773 cold sensitive neomorphic allele - genetic evidence FBcv:0000773 An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some low temperatures (non-permissive temperatures) but not higher temperatures (permissive temperatures), based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some high temperatures (non-permissive temperatures) but not lower temperatures (permissive temperatures), based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene. 2012-03-22T03:59:43Z allele_class FBcv:0000774 heat sensitive neomorphic allele - genetic evidence FBcv:0000774 An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some high temperatures (non-permissive temperatures) but not lower temperatures (permissive temperatures), based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at some temperatures but not others. 2012-03-22T03:55:17Z allele_class FBcv:0000775 temperature conditional neomorphic allele - molecular evidence FBcv:0000775 An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at some temperatures but not others. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at low temperatures but not higher temperatures. 2012-03-22T03:58:31Z allele_class FBcv:0000776 cold sensitive neomorphic allele - molecular evidence FBcv:0000776 An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at low temperatures but not higher temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at high temperatures but not lower temperatures. 2012-03-22T03:59:43Z allele_class FBcv:0000777 heat sensitive neomorphic allele - molecular evidence FBcv:0000777 An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at high temperatures but not lower temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that, at some temperatures but not others, makes a gene product with normal function but at higher levels or with higher activity than in wild-type. 2012-03-22T03:57:02Z allele_class FBcv:0000778 temperature conditional hypermorphic allele FBcv:0000778 An allele that, at some temperatures but not others, makes a gene product with normal function but at higher levels or with higher activity than in wild-type. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that, at high temperatures but not lower temperatures, makes a gene product with normal function but at higher levels or with higher activity than in wild-type. 2012-03-22T03:54:34Z allele_class FBcv:0000779 heat sensitive hypermorphic allele FBcv:0000779 An allele that, at high temperatures but not lower temperatures, makes a gene product with normal function but at higher levels or with higher activity than in wild-type. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele that, at low temperatures but not higher temperatures, makes a gene product with normal function but at higher levels or with higher activity than in wild-type.. allele_class FBcv:0000780 cold sensitive hypermorphic allele FBcv:0000780 An allele that, at low temperatures but not higher temperatures, makes a gene product with normal function but at higher levels or with higher activity than in wild-type.. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at some temperatures (non-permissive temperatures) but not others (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures. 2012-03-22T03:55:17Z allele_class FBcv:0000781 temperature conditional hypermorphic allele - genetic evidence FBcv:0000781 An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at some temperatures (non-permissive temperatures) but not others (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at low temperatures (non-permissive temperatures) but not higher temperatures (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures. 2012-03-22T03:58:31Z allele_class FBcv:0000782 cold sensitive hypermorphic allele - genetic evidence FBcv:0000782 An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at low temperatures (non-permissive temperatures) but not higher temperatures (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at high temperatures (non-permissive temperatures) but not lower temperatures (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures. 2012-03-22T03:59:43Z allele_class FBcv:0000783 heat sensitive hypermorphic allele - genetic evidence FBcv:0000783 An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at high temperatures (non-permissive temperatures) but not lower temperatures (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at some temperatures but not others. 2012-03-22T03:55:17Z allele_class FBcv:0000784 temperature conditional hypermorphic allele - molecular evidence FBcv:0000784 An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at some temperatures but not others. FBC:DOS FlyBase:FBrf0049147 An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at low temperatures but not higher temperatures. 2012-03-22T03:58:31Z allele_class FBcv:0000785 cold sensitive hypermorphic allele - molecular evidence FBcv:0000785 An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at low temperatures but not higher temperatures. FBC:DOS FlyBase:FBrf0049147 An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at high temperatures but not lower temperatures. 2012-03-22T03:59:43Z allele_class FBcv:0000786 heat sensitive hypermorphic allele - molecular evidence FBcv:0000786 An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at high temperatures but not lower temperatures. FBC:DOS FlyBase:FBrf0049147 A publication issued on a regular, ongoing basis containing separate research articles and other writings such as reviews, comments and conference reports. 2012-07-10T04:08:06Z MeSH:D020492 pub_type Periodicals FBcv:0000787 journal FBcv:0000787 A publication issued on a regular, ongoing basis containing separate research articles and other writings such as reviews, comments and conference reports. FBC:SM MeSH:D020492 Periodicals MeSH:D020492 A work consisting of a news item appearing in a general-interest newspaper or other general news periodical, containing information of current and timely interest in the field of medicine or science. 2012-07-10T04:17:34Z MeSH:D018431 pub_type FBcv:0000788 newspaper article FBcv:0000788 A work consisting of a news item appearing in a general-interest newspaper or other general news periodical, containing information of current and timely interest in the field of medicine or science. FBC:SM MeSH:D018431 A record of a nucleotide or protein sequence in some standard format. 2012-07-10T05:42:47Z pub_type FBcv:0000789 sequence record FBcv:0000789 A record of a nucleotide or protein sequence in some standard format. FBC:SM Work consisting of a structured file of information or a set of logically related data stored and retrieved using computer-based means. 2012-07-13T02:06:57Z MeSH:D019991 pub_type FBcv:0000790 database FBcv:0000790 Work consisting of a structured file of information or a set of logically related data stored and retrieved using computer-based means. FBC:SM MeSH:D019991 A phenotype in which the aging process is slower than in wild-type. reduced speed of aging phenotypic_class delayed aging FBcv:0000791 decreased speed of aging FBcv:0000791 A phenotype in which the aging process is slower than in wild-type. FBC:DOC A phenotype in which the aging process is accelerated compared to wild-type. phenotypic_class premature aging FBcv:0000792 increased speed of aging FBcv:0000792 A phenotype in which the aging process is accelerated compared to wild-type. FBC:DOC A phenotype that becomes more severe with age. 2012-10-10T12:02:35Z temporal_qualifier FBcv:0000793 progressive FBcv:0000793 A phenotype that becomes more severe with age. FBC:DOS Cell autonomy statements describe the cellular focus of mutant phenotype, generally revealed by genetic mosaic analysis, in terms of whether the mutant has its phenotypic effect limited to, or not limited to, cells of the mutant genotype. genotype_to_phenotype_relation FBcv:0000797 cell autonomy qualifier FBcv:0000797 Cell autonomy statements describe the cellular focus of mutant phenotype, generally revealed by genetic mosaic analysis, in terms of whether the mutant has its phenotypic effect limited to, or not limited to, cells of the mutant genotype. FBC:rd FlyBase miscellaneous CV FBcv:0000799 obsolete gene descriptor true FBcv:0000799 FlyBase miscellaneous CV FBcv:0000801 obsolete polymorphism assay true FBcv:0000801 FlyBase miscellaneous CV restriction fragment length polymorphism FBcv:0000803 obsolete RFLP true FBcv:0000803 FlyBase miscellaneous CV FBcv:0000805 obsolete DNA sequence variant true FBcv:0000805 Descriptor that relates to aspects of an allele. FlyBase miscellaneous CV FBcv:0000807 allele descriptor FBcv:0000807 Descriptor that relates to aspects of an allele. FBC:MMC Qualifier that describes an observable phenotype. FlyBase miscellaneous CV FBcv:0000809 phenotype qualifier FBcv:0000809 Qualifier that describes an observable phenotype. FBC:MMC Qualifier that describes a particular quality of an observable phenotype. FlyBase miscellaneous CV FBcv:0000811 qualitative qualifier FBcv:0000811 Qualifier that describes a particular quality of an observable phenotype. FBC:MMC A clone of cells that share a genotype. clone_qualifier clone qualifier FBcv:0000812 clone of cells FBcv:0000812 A clone of cells that share a genotype. FBC:DOS Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR (from CHEBI). mutation induced by nitrogen mustard exposure origin_of_mutation 2-chloro-N-(2-chloroethyl)-N-methylethanamine CB1414 HN2 mechlorethamine FBcv:0000813 nitrogen mustard FBcv:0000813 Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR (from CHEBI). CHEBI:37598 A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant (from CHEBI). mutation induced by 1,4-dimethanesulfonoxybutane exposure mutation induced by busulfan exposure origin_of_mutation CB2041 busulfan FBcv:0000814 1,4-dimethanesulfonoxybutane FBcv:0000814 A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant (from CHEBI). CHEBI:28901 busulfan CHEBI:28901 A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia (from CHEBI). chlorambucil mutation induced by chlorambucil exposure mutation induced by p-N,N-di-(2-chloroethyl)aminophenylbutyric acid exposure origin_of_mutation CB1348 FBcv:0000815 p-N,N-di-(2-chloroethyl)aminophenylbutyric acid FBcv:0000815 A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia (from CHEBI). CHEBI:28830 chlorambucil CHEBI:28830 An allele that completely lacks function (i.e. whose gene productive is completely inactive) at low temperatures, but that retains at least some function at higher temperatures. FlyBase miscellaneous CV FBcv:0001003 cold sensitive amorphic allele FBcv:0001003 An allele that completely lacks function (i.e. whose gene productive is completely inactive) at low temperatures, but that retains at least some function at higher temperatures. FBC:DOS FlyBase:FBrf0002371 FlyBase:FBrf0049147 Phenotype expressed only in the presence of beta-estradiol (CHEBI:16469). conditional beta-estradiol environmental_qualifier FBcv:0001315 beta-estradiol conditional FBcv:0001315 Phenotype expressed only in the presence of beta-estradiol (CHEBI:16469). FBC:DOS Phenotype that is a defect in endocytosis (GO:0006897). 'endocytosis' is defined as: 'A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.' abnormal endocytosis phenotypic_class FBcv:0001324 Obsoleted as this is phenotype is too molecular to be captured by FlyBase phenotype curation and will be captured by GO curation [FBC:CP]. obsolete endocytosis defective true FBcv:0001324 Phenotype that is a defect in endocytosis (GO:0006897). 'endocytosis' is defined as: 'A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.' FBC:DOS Phenotype that is a defect in exocytosis (GO:0006887). 'exocytosis' is defined as: 'A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.' abnormal exocytosis phenotypic_class FBcv:0001325 Obsoleted as this is phenotype is too molecular to be captured by FlyBase phenotype curation and will be captured by GO curation [FBC:CP]. obsolete exocytosis defective true FBcv:0001325 Any abnormality in or loss of some anatomical structure or biological process compared to wild-type. phenotypic class phenotypic_class FBcv:0001347 The subclasses of this term classify Drosophila phenotypes into different common categories. They have been chosen by FlyBase to reflect phenotype terms most often reported by Drosophila researchers in the published literature. phenotype FBcv:0001347 Any abnormality in or loss of some anatomical structure or biological process compared to wild-type. FBC:DOS Mutation induced by the transposable activity caused by Minos, a DNA transposable element. The minos element is 1.4 kilobases in length with 254 base pairs inverted terminal repeats. It specifically targets TA dinucleotides and generates a flanking duplication of 2 base pairs upon insertion. Mobilization is induced by the activity of the minos transposase. mutation induced by minos activity origin_of_mutation FBcv:0001500 minos activity FBcv:0001500 Mutation induced by the transposable activity caused by Minos, a DNA transposable element. The minos element is 1.4 kilobases in length with 254 base pairs inverted terminal repeats. It specifically targets TA dinucleotides and generates a flanking duplication of 2 base pairs upon insertion. Mobilization is induced by the activity of the minos transposase. FBC:DOS FlyBase:FBrf0202435 A phenotype of a population that is the death of all animals in that population at some stage or stages prior to eclosion from the pupal case (the end of the P-stage). pupal lethal lethal - all die before end of pharate adult stage phenotypic_class FBcv:0002000 As the P-Stage and the 'pharate adult stage' have the same end, there is no need for a separate term for 'lethal - all die before end of pharate adult stage. lethal - all die before end of P-stage FBcv:0002000 A phenotype of a population that is the death of all animals in that population at some stage or stages prior to eclosion from the pupal case (the end of the P-stage). FBC:DOS A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the first instar larval stage. phenotypic_class FBcv:0002001 lethal - all die before end of first instar larval stage FBcv:0002001 A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the first instar larval stage. FBC:DOS A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the larval stage. larval lethal lethal - all die before end of third instar larval stage phenotypic_class FBcv:0002002 As the larval stage and third instar larval stage have the same end, there is no need for a separate term for 'lethal - all die before end of third instar larval stage'. lethal - all die before end of larval stage FBcv:0002002 A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the larval stage. FBC:DOS A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the second instar larval stage. phenotypic_class FBcv:0002003 lethal - all die before end of second instar larval stage FBcv:0002003 A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the second instar larval stage. FBC:DOS A phenotype that is an increase in the rate of death in a population at any stage of life (during development or adulthood), over the rate seen in a wild type control population. phenotypic_class FBcv:0002004 increased mortality FBcv:0002004 A phenotype that is an increase in the rate of death in a population at any stage of life (during development or adulthood), over the rate seen in a wild type control population. FBC:DOS A phenotype of a population that is the death of all animals in that population during the P-stage. pupal lethal phenotypic_class FBcv:0002005 lethal - all die during P-stage FBcv:0002005 A phenotype of a population that is the death of all animals in that population during the P-stage. FBC:DOS A phenotype of a population that is the death of all animals in that population during the first instar larval stage. phenotypic_class FBcv:0002006 lethal - all die during first instar larval stage FBcv:0002006 A phenotype of a population that is the death of all animals in that population during the first instar larval stage. FBC:DOS A phenotype of a population that is the death of all animals in that population during the larval stage. larval lethal phenotypic_class FBcv:0002007 lethal - all die during larval stage FBcv:0002007 A phenotype of a population that is the death of all animals in that population during the larval stage. FBC:DOS A phenotype of a population that is the death of all animals in that population during the second instar larval stage. phenotypic_class FBcv:0002008 lethal - all die during second instar larval stage FBcv:0002008 A phenotype of a population that is the death of all animals in that population during the second instar larval stage. FBC:DOS A phenotype of a population that is the death of all animals in that population during the third instar larval stage. phenotypic_class FBcv:0002009 lethal - all die during third instar larval stage FBcv:0002009 A phenotype of a population that is the death of all animals in that population during the third instar larval stage. FBC:DOS A phenotype of a population that is the death of the majority of animals in that population during the P-stage. phenotypic_class FBcv:0002010 majority die during P-stage FBcv:0002010 A phenotype of a population that is the death of the majority of animals in that population during the P-stage. FBC:DOS A phenotype of a population that is the death of the majority of animals in that population during the first instar larval stage. phenotypic_class FBcv:0002011 majority die during first instar larval stage FBcv:0002011 A phenotype of a population that is the death of the majority of animals in that population during the first instar larval stage. FBC:DOS A phenotype of a population that is the death of the majority of animals in that population during the larval stage. phenotypic_class FBcv:0002012 majority die during larval stage FBcv:0002012 A phenotype of a population that is the death of the majority of animals in that population during the larval stage. FBC:DOS A phenotype of a population that is the death of the majority of animals in that population during the second instar larval stage. phenotypic_class FBcv:0002013 majority die during second instar larval stage FBcv:0002013 A phenotype of a population that is the death of the majority of animals in that population during the second instar larval stage. FBC:DOS A phenotype of a population that is the death of the majority of animals in that population during the third instar larval stage. phenotypic_class FBcv:0002014 majority die during third instar larval stage FBcv:0002014 A phenotype of a population that is the death of the majority of animals in that population during the third instar larval stage. FBC:DOS A phenotype of a population that is the death of some significant proportion of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). phenotypic_class FBcv:0002015 partially lethal FBcv:0002015 A phenotype of a population that is the death of some significant proportion of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). FBC:DOS FBC:KM A phenotype of a population that is the death of a significant proportion of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). phenotypic_class FBcv:0002019 increased mortality during development FBcv:0002019 A phenotype of a population that is the death of a significant proportion of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012). FBC:DOS A phenotype of a population that is the death of a significant proportion of animals in that population during the P-stage. phenotypic_class FBcv:0002020 some die during P-stage FBcv:0002020 A phenotype of a population that is the death of a significant proportion of animals in that population during the P-stage. FBC:DOS A phenotype of a population that is the death of a significant proportion of animals in that population during the first instar larval stage. phenotypic_class FBcv:0002021 some die during first instar larval stage FBcv:0002021 A phenotype of a population that is the death of a significant proportion of animals in that population during the first instar larval stage. FBC:DOS A phenotype of a population that is the death of a significant proportion of animals in that population during the second instar larval stage. phenotypic_class FBcv:0002022 some die during second instar larval stage FBcv:0002022 A phenotype of a population that is the death of a significant proportion of animals in that population during the second instar larval stage. FBC:DOS A phenotype of a population that is the death of a significant proportion of animals in that population during the larval stage. phenotypic_class FBcv:0002023 some die during larval stage FBcv:0002023 A phenotype of a population that is the death of a significant proportion of animals in that population during the larval stage. FBC:DOS A phenotype of a population that is the death of a significant proportion of animals in that population during the third instar larval stage. phenotypic_class FBcv:0002024 some die during third instar larval stage FBcv:0002024 A phenotype of a population that is the death of a significant proportion of animals in that population during the third instar larval stage. FBC:DOS A phenotype of a population that is the death of all animals in that population during the pharate adult stage. phenotypic_class FBcv:0002025 lethal - all die during pharate adult stage FBcv:0002025 A phenotype of a population that is the death of all animals in that population during the pharate adult stage. FBC:DOS A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the prepupal stage. phenotypic_class FBcv:0002026 lethal - all die before end of prepupal stage FBcv:0002026 A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the prepupal stage. FBC:DOS A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the pupal stage. pupal lethal phenotypic_class FBcv:0002027 lethal - all die before end of pupal stage FBcv:0002027 A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the pupal stage. FBC:DOS A phenotype of a population that is the death of all animals in that population during the pupal stage. pupal lethal phenotypic_class FBcv:0002030 lethal - all die during pupal stage FBcv:0002030 A phenotype of a population that is the death of all animals in that population during the pupal stage. FBC:DOS A phenotype of a population that is the death of all animals in that population during the prepupal stage. phenotypic_class FBcv:0002031 lethal - all die during prepupal stage FBcv:0002031 A phenotype of a population that is the death of all animals in that population during the prepupal stage. FBC:DOS FBcv:0002032 A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the embryonic stage. FBcv:0002033 phenotypic_class Obsoleted due to equivalence with FBcv:0002033 'lethal - all die during embryonic stage'. obsolete lethal - all die before end of embryonic stage true A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the embryonic stage. FBC:DOS A phenotype of a population that is the death of all animals in that population during the embryonic stage. embryonic lethal phenotypic_class FBcv:0002033 lethal - all die during embryonic stage FBcv:0002033 A phenotype of a population that is the death of all animals in that population during the embryonic stage. FBC:DOS A phenotype of a population that is the death of the majority of animals in that population during the pupal stage. phenotypic_class FBcv:0002034 majority die during pupal stage FBcv:0002034 A phenotype of a population that is the death of the majority of animals in that population during the pupal stage. FBC:DOS A phenotype of a population that is the death of the majority of animals in that population during the prepupal stage. phenotypic_class FBcv:0002035 majority die during prepupal stage FBcv:0002035 A phenotype of a population that is the death of the majority of animals in that population during the prepupal stage. FBC:DOS A phenotype of a population that is the death of the majority of animals in that population during the pharate adult stage. phenotypic_class FBcv:0002036 majority die during pharate adult stage FBcv:0002036 A phenotype of a population that is the death of the majority of animals in that population during the pharate adult stage. FBC:DOS A phenotype of a population that is the death of the majority of animals in that population during the embryonic stage. phenotypic_class FBcv:0002037 This term is agnostic about whether any survive to adulthood. majority die during embryonic stage FBcv:0002037 A phenotype of a population that is the death of the majority of animals in that population during the embryonic stage. FBC:DOS A phenotype of a population that is the death of a significant proportion of animals in that population during the pharate adult stage. phenotypic_class FBcv:0002038 some die during pharate adult stage FBcv:0002038 A phenotype of a population that is the death of a significant proportion of animals in that population during the pharate adult stage. FBC:DOS A phenotype of a population that is the death of a significant proportion of animals in that population during the pupal stage. phenotypic_class FBcv:0002039 some die during pupal stage FBcv:0002039 A phenotype of a population that is the death of a significant proportion of animals in that population during the pupal stage. FBC:DOS A phenotype of a population that is the death of a significant proportion of animals in that population during the prepupal stage. phenotypic_class FBcv:0002040 some die during prepupal stage FBcv:0002040 A phenotype of a population that is the death of a significant proportion of animals in that population during the prepupal stage. FBC:DOS A phenotype of a population that is the death of a significant proportion of animals in that population during the embryonic stage. phenotypic_class FBcv:0002041 some die during embryonic stage FBcv:0002041 A phenotype of a population that is the death of a significant proportion of animals in that population during the embryonic stage. FBC:DOS A phenotype of a population that is the death of all animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012)). phenotypic_class FBcv:0002042 lethal - all die during immature adult stage FBcv:0002042 A phenotype of a population that is the death of all animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012)). FBC:DOS A phenotype of a population that is the death of the majority of animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012)). phenotypic_class FBcv:0002050 majority die during immature adult stage FBcv:0002050 A phenotype of a population that is the death of the majority of animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012)). FBC:DOS A phenotype of a population that is the death of some significant number of animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012)). phenotypic_class FBcv:0002051 some die during immature adult stage FBcv:0002051 A phenotype of a population that is the death of some significant number of animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012)). FBC:DOS Qualifier that describes aspects of genetic models of disease. 2014-03-27T11:07:29Z disease_qualifier FBcv:0003000 disease qualifier FBcv:0003000 Qualifier that describes aspects of genetic models of disease. FBC:MMC Makes a condition better. 2014-03-27T11:07:29Z disease_qualifier FBcv:0003001 The 'ameliorates' term is used in FlyBase disease annotation when an allele interacts to remove or reduce the severity of the disease phenotype associated with a given disease model (FBC:ST). ameliorates FBcv:0003001 Makes a condition better. FBC:ST Contrary to expectation, does not make a condition better. 2014-03-27T11:07:29Z disease_qualifier FBcv:0003002 The 'DOES NOT ameliorate' term is used in FlyBase disease annotation when an allele is expected to remove or reduce the severity of the disease phenotype associated with a given disease model but fails to do so. DOES NOT ameliorate FBcv:0003002 Contrary to expectation, does not make a condition better. FBC:ST Contrary to expectation, does not make a condition worse. 2014-03-27T11:07:29Z disease_qualifier FBcv:0003003 The 'DOES NOT exacerbate' term is used in FlyBase disease annotation when an allele is expected to makes the disease phenotype associated with a given disease model more severe but fails to do so (FBC:ST). DOES NOT exacerbate FBcv:0003003 Contrary to expectation, does not make a condition worse. FBC:ST Contrary to expectation, characteristics associated with a given condition are not recapitulated in a different system. 2014-03-27T11:07:29Z disease_qualifier FBcv:0003004 The 'DOES NOT model' term is used in FlyBase disease annotation when an allele is expected to recapitulate one or more aspects of a particular human disease phenotype in Drosophila but fails to do so (FBC:ST). DOES NOT model FBcv:0003004 Contrary to expectation, characteristics associated with a given condition are not recapitulated in a different system. FBC:ST Makes a condition worse. 2014-03-27T11:07:29Z disease_qualifier FBcv:0003005 The 'exacerbates' term is used in FlyBase disease annotation when an allele interacts to make the disease phenotype associated with a given disease model more severe (FBC:ST). exacerbates FBcv:0003005 Makes a condition worse. FBC:ST Characteristics associated with a given condition recapitulated in a different system. 2014-03-27T11:07:29Z disease_qualifier FBcv:0003006 The 'model of' term is used in FlyBase disease annotation when alleles (typically of fly or human genes) recapitulate one or more aspect of a human disease phenotype in Drosophila (FBC:ST). model of FBcv:0003006 Characteristics associated with a given condition recapitulated in a different system. FBC:ST Sequence change induced by a cleavage event that is caused by an endonuclease that recognizes and cleaves specific sequences in double stranded DNA causing double-strand breaks (DSB). 2014-03-27T11:07:29Z change induced by site specific cleavage origin_of_mutation FBcv:0003007 site specific cleavage FBcv:0003007 Sequence change induced by a cleavage event that is caused by an endonuclease that recognizes and cleaves specific sequences in double stranded DNA causing double-strand breaks (DSB). FlyBase:FBrf0202435 Sequence change caused by a cleavage of a specific DNA sequence induced by CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 nuclease system. This system relies on the transcription of a chimeric guide RNA (gRNA) which directs the Cas9 endonuclease to a specified DNA sequence through basepairing to 20 nucleotide CRISPR target sites. These sites are located next to a 3 nucleotide protospacer adjacent motif (PAM) required for DNA cleavage. 2014-03-27T11:07:29Z change induced by CRISPR/Cas9 endonuclease cleavage origin_of_mutation CRISPR/Cas9 endonuclease FBcv:0003008 CRISPR/Cas9 FBcv:0003008 Sequence change caused by a cleavage of a specific DNA sequence induced by CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 nuclease system. This system relies on the transcription of a chimeric guide RNA (gRNA) which directs the Cas9 endonuclease to a specified DNA sequence through basepairing to 20 nucleotide CRISPR target sites. These sites are located next to a 3 nucleotide protospacer adjacent motif (PAM) required for DNA cleavage. FlyBase:FBrf0222128 FlyBase:FBrf0222292 FlyBase:FBrf0222617 UniProt:Q99ZW2 Sequence change caused by the cleavage of specific DNA sequences by transcription activator-like effector nucleases (TALENs). TALEN proteins comprise a DNA binding domain fused to the catalytic domain of the FokI endonuclease. The DNA binding domain contains a repetitive region within the middle of the protein, consisting of tandem repeats of 34 amino acid segments, with each of these segments recognizing a single base pair. The specificity of the binding is determined by two hypervariable amino acids in positions 12 and 13 (repeat-variable diresidues). Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of TALENs which bind to adjacent sequences separated by a spacer region, allowing dimerization and promoting cleavage. 2014-03-27T11:07:29Z change induced by TALE endonuclease cleavage origin_of_mutation TALE endonuclease FBcv:0003009 TALEN FBcv:0003009 Sequence change caused by the cleavage of specific DNA sequences by transcription activator-like effector nucleases (TALENs). TALEN proteins comprise a DNA binding domain fused to the catalytic domain of the FokI endonuclease. The DNA binding domain contains a repetitive region within the middle of the protein, consisting of tandem repeats of 34 amino acid segments, with each of these segments recognizing a single base pair. The specificity of the binding is determined by two hypervariable amino acids in positions 12 and 13 (repeat-variable diresidues). Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of TALENs which bind to adjacent sequences separated by a spacer region, allowing dimerization and promoting cleavage. PMID:10954606 PMID:20660643 Sequence change caused by a site specific recombination catalyzed by the serine recombinase phiC31 integrase that recognizes a minimal high-efficiency attP recognition site of 39 base pairs and a minimal high-efficiency attB recognition site of 34 base pairs. The attP and attB sites contain imperfect inverted repeats flanking a short recombination core (TTG) that provides directionality. 2014-03-27T11:07:29Z change induced by phiC31 integrase recombination origin_of_mutation FBcv:0003010 phiC31 integrase FBcv:0003010 Sequence change caused by a site specific recombination catalyzed by the serine recombinase phiC31 integrase that recognizes a minimal high-efficiency attP recognition site of 39 base pairs and a minimal high-efficiency attB recognition site of 34 base pairs. The attP and attB sites contain imperfect inverted repeats flanking a short recombination core (TTG) that provides directionality. FlyBase:FBrf0174693 FlyBase:FBrf0201927 UniProt:Q9T221 Descriptor that relates aspects of the grouping of genes or gene products. 2014-03-28T15:23:42Z group_descriptor FBcv:0003011 group descriptor FBcv:0003011 Descriptor that relates aspects of the grouping of genes or gene products. FBC:MMC Genes or gene products that are acknowledged to form a natural biological group. 2014-03-28T15:23:42Z group_descriptor FBcv:0003012 gene or gene product group FBcv:0003012 Genes or gene products that are acknowledged to form a natural biological group. FBC:SM Two or more genes contiguously arranged where the individual genes are either identical in sequence, or essentially so (SO:0005851). 2014-03-28T15:23:42Z group_descriptor FBcv:0003013 gene array group FBcv:0003013 Two or more genes contiguously arranged where the individual genes are either identical in sequence, or essentially so (SO:0005851). FBC:SM SO:ma Genes whose products share a common biological and/or molecular function. 2014-03-28T15:23:42Z group_descriptor FBcv:0003014 functional group FBcv:0003014 Genes whose products share a common biological and/or molecular function. FBC:SM Genes with the same location on the chromosome and whose products have a similar function. 2014-03-28T15:23:42Z group_descriptor FBcv:0003015 gene complex group FBcv:0003015 Genes with the same location on the chromosome and whose products have a similar function. FBC:SM http://www.sdbonline.org/fly/aignfam/ensplitc.htm Genes whose protein products form a macromolecular complex (GO:0043234). 2014-03-28T15:23:42Z group_descriptor FBcv:0003016 protein complex group FBcv:0003016 Genes whose protein products form a macromolecular complex (GO:0043234). FBC:SM GOC:go_curators Genes whose products act in a specified signal transduction or metabolic pathway. 2014-03-28T15:23:42Z group_descriptor FBcv:0003017 pathway group FBcv:0003017 Genes whose products act in a specified signal transduction or metabolic pathway. FBC:SM Genes whose products act in a specified biological process. 2014-03-28T15:23:42Z group_descriptor FBcv:0003018 process group FBcv:0003018 Genes whose products act in a specified biological process. FBC:SM Mutation caused by the transposable activity caused by the I-element, a non-LTR retrotransposon. The I-element is 5371 base pairs long. Mobilization is induced by the activity of the I-element transposase. 2014-09-16T13:30:48Z mutation induced by I-element activity origin_of_mutation FBcv:0003019 I-element activity FBcv:0003019 Mutation caused by the transposable activity caused by the I-element, a non-LTR retrotransposon. The I-element is 5371 base pairs long. Mobilization is induced by the activity of the I-element transposase. FlyBase:FBrf0202435 Mutation caused by the transposable activity caused by the Stalker element, a LTR retrotransposon. Mobilization is induced by the activity of the stalker element transposase. 2014-09-16T13:30:48Z mutation induced by Stalker element activity origin_of_mutation FBcv:0003020 Stalker element activity FBcv:0003020 Mutation caused by the transposable activity caused by the Stalker element, a LTR retrotransposon. Mobilization is induced by the activity of the stalker element transposase. FlyBase:FBrf0202435 Term that describes a dataset. 2016-02-24T19:19:21Z FlyBase miscellaneous CV FBcv:0003021 dataset descriptor FBcv:0003021 Term that describes a dataset. FBC:GD Term that specifies the dataset component type. 2016-02-24T19:19:21Z dataset_entity_type FBcv:0003022 dataset entity type FBcv:0003022 Term that specifies the dataset component type. FBC:GD A set of biological data from a single study. Corresponds to the NCBI bioproject, GEO series or SRA study. 2016-02-24T19:19:21Z dataset_entity_type FBcv:0003023 project FBcv:0003023 A set of biological data from a single study. Corresponds to the NCBI bioproject, GEO series or SRA study. FBC:GD Biological source material characterized by an experiment. 2016-02-24T19:19:21Z dataset_entity_type FBcv:0003024 biosample FBcv:0003024 Biological source material characterized by an experiment. FBC:GD Quantitative or qualitative assessment of biological source material to measure some attribute. 2016-02-24T19:19:21Z dataset_entity_type FBcv:0003025 assay FBcv:0003025 Quantitative or qualitative assessment of biological source material to measure some attribute. FBC:GD Analysis of raw data generated by an assay(s) that makes some conclusion. 2016-02-24T19:19:21Z dataset_entity_type FBcv:0003026 result FBcv:0003026 Analysis of raw data generated by an assay(s) that makes some conclusion. FBC:GD A collection of material reagents. 2016-02-24T19:19:21Z dataset_entity_type FBcv:0003027 reagent collection FBcv:0003027 A collection of material reagents. FBC:GD The data type content of a dataset. 2016-02-24T19:19:21Z FlyBase miscellaneous CV FBcv:0003028 dataset data type FBcv:0003028 The data type content of a dataset. FBC:GD The type of project as characterized its data content. 2016-02-24T19:19:21Z project_type FBcv:0003029 project type FBcv:0003029 The type of project as characterized its data content. FBC:GD A project that groups together related sub-projects. 2016-02-24T19:19:21Z project_type FBcv:0003030 umbrella project FBcv:0003030 A project that groups together related sub-projects. FBC:GD A project that characterizes an organism's genome sequence. 2016-02-24T19:19:21Z project_type FBcv:0003031 genome FBcv:0003031 A project that characterizes an organism's genome sequence. FBC:GD A project that characterizes the intraspecific variation of an organism's genome. 2016-02-24T19:19:21Z project_type FBcv:0003032 genome variation FBcv:0003032 A project that characterizes the intraspecific variation of an organism's genome. FBC:GD A project that characterizes the occupancy profile of a factor that binds directly or indirectly to the genome. 2016-02-24T19:19:21Z project_type FBcv:0003033 genome binding FBcv:0003033 A project that characterizes the occupancy profile of a factor that binds directly or indirectly to the genome. FBC:GD A project that characterizes the set of transcribed RNA sequences expressed by the genome. 2016-02-24T19:19:21Z project_type FBcv:0003034 transcriptome FBcv:0003034 A project that characterizes the set of transcribed RNA sequences expressed by the genome. FBC:GD A project that characterizes the set of proteins expressed in an organism. 2016-02-24T19:19:21Z project_type FBcv:0003035 proteome FBcv:0003035 A project that characterizes the set of proteins expressed in an organism. FBC:GD A project that characterizes the set of inter-molecular interactions in an organism. 2016-02-24T19:19:21Z project_type FBcv:0003036 interactome FBcv:0003036 A project that characterizes the set of inter-molecular interactions in an organism. FBC:GD A project that characterizes the set of small molecules in an organism. 2016-02-24T19:19:21Z project_type FBcv:0003037 metabolome FBcv:0003037 A project that characterizes the set of small molecules in an organism. FBC:GD A project that searches for the genes responsible for a particular observable trait. 2016-02-24T19:19:21Z project_type FBcv:0003038 phenotypic screen FBcv:0003038 A project that searches for the genes responsible for a particular observable trait. FBC:GD A project that searches for chemicals, natural or synthetic, that elicit some biological effect. 2016-02-24T19:19:21Z project_type FBcv:0003039 chemical screen FBcv:0003039 A project that searches for chemicals, natural or synthetic, that elicit some biological effect. FBC:GD A project that constructs models describing the set of transcripts and polypeptides encoded by some group of genes. 2016-02-24T19:19:21Z project_type FBcv:0003040 gene model annotation FBcv:0003040 A project that constructs models describing the set of transcripts and polypeptides encoded by some group of genes. FBC:GD A project that reconstructs the evolutionary history of a group of genes or organisms. 2016-02-24T19:19:21Z project_type FBcv:0003041 phylogenetic analysis FBcv:0003041 A project that reconstructs the evolutionary history of a group of genes or organisms. FBC:GD A project that describes a large material resource that is accessible to the community. 2016-02-24T19:19:21Z project_type FBcv:0003042 reagent FBcv:0003042 A project that describes a large material resource that is accessible to the community. FBC:GD A project type that is not described by other more specific terms. 2016-02-24T19:19:21Z project_type FBcv:0003043 other FBcv:0003043 A project type that is not described by other more specific terms. FBC:GD The type of biosample as characterized by its biological source material. 2016-02-24T19:19:21Z biosample_type FBcv:0003044 biosample type FBcv:0003044 The type of biosample as characterized by its biological source material. FBC:GD A biosample that comprises the whole animal. 2016-02-24T19:19:21Z biosample_type FBcv:0003045 whole organism FBcv:0003045 A biosample that comprises the whole animal. FBC:GD A biosample derived from a multicellular structure comprising similar cells with some specific function, typically isolated by dissection. 2016-02-24T19:19:21Z biosample_type FBcv:0003046 tissue FBcv:0003046 A biosample derived from a multicellular structure comprising similar cells with some specific function, typically isolated by dissection. FBC:GD A biosample containing dissociated cells isolated from the organism, typically isolated by affinity capture or sorting methods. 2016-02-24T19:19:21Z biosample_type FBcv:0003047 isolated cells FBcv:0003047 A biosample containing dissociated cells isolated from the organism, typically isolated by affinity capture or sorting methods. FBC:GD A biosample consisting of cells that were isolated from animal tissue and cultured in vitro for a limited amount of time. 2016-02-24T19:19:21Z biosample_type FBcv:0003048 primary cell line FBcv:0003048 A biosample consisting of cells that were isolated from animal tissue and cultured in vitro for a limited amount of time. FBC:GD A biosample consisting of cells isolated from animal tissue that have acquired the ability to proliferate indefinitely. 2016-02-24T19:19:21Z biosample_type FBcv:0003049 immortalized cell line FBcv:0003049 A biosample consisting of cells isolated from animal tissue that have acquired the ability to proliferate indefinitely. FBC:GD The type of assay as characterized by its data content. 2016-02-24T19:19:21Z assay_type FBcv:0003050 assay type FBcv:0003050 The type of assay as characterized by its data content. FBC:GD An assay of 5' capped transcripts, using CAGE to biotinylate and isolate the 7-methylguanosine cap, with subsequent characterization by high-throughput sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003051 CAGE-Seq FBcv:0003051 An assay of 5' capped transcripts, using CAGE to biotinylate and isolate the 7-methylguanosine cap, with subsequent characterization by high-throughput sequencing. FBC:GD A genome binding assay of some factor as characterized by chromatin immunoprecipitation (ChIP) of that factor and analysis of co-purifying DNA fragments using genome tiling array. 2016-02-24T19:19:21Z assay_type FBcv:0003052 ChIP-chip FBcv:0003052 A genome binding assay of some factor as characterized by chromatin immunoprecipitation (ChIP) of that factor and analysis of co-purifying DNA fragments using genome tiling array. FBC:GD A genome binding assay of some factor as characterized by chromatin immunoprecipitation (ChIP) of that factor and high-throughput sequencing of co-purifying DNA fragments. 2016-02-24T19:19:21Z assay_type FBcv:0003053 ChIP-Seq FBcv:0003053 A genome binding assay of some factor as characterized by chromatin immunoprecipitation (ChIP) of that factor and high-throughput sequencing of co-purifying DNA fragments. FBC:GD An RNA binding assay of some protein as characterized by cross-linking immunoprecipitation (CLiP) and high-throughput sequencing of co-purifying RNA fragments. 2016-02-24T19:19:21Z assay_type FBcv:0003054 CLiP-Seq FBcv:0003054 An RNA binding assay of some protein as characterized by cross-linking immunoprecipitation (CLiP) and high-throughput sequencing of co-purifying RNA fragments. FBC:GD A genome binding assay of some protein as characterized by creating a fusion to DNA adenine methyltransferase and analysis of methylated DNA sequences by genome tiling array. 2016-02-24T19:19:21Z assay_type FBcv:0003055 DamID-chip FBcv:0003055 A genome binding assay of some protein as characterized by creating a fusion to DNA adenine methyltransferase and analysis of methylated DNA sequences by genome tiling array. FBC:GD A genome binding assay of some protein as characterized by creating a fusion to DNA adenine methyltransferase and analysis of methylated DNA sequences by high-throughput sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003056 DamID-Seq FBcv:0003056 A genome binding assay of some protein as characterized by creating a fusion to DNA adenine methyltransferase and analysis of methylated DNA sequences by high-throughput sequencing. FBC:GD An assay that characterizes the genome's DNase hypersensitivity using genome tiling array. 2016-02-24T19:19:21Z assay_type FBcv:0003057 DNase-chip FBcv:0003057 An assay that characterizes the genome's DNase hypersensitivity using genome tiling array. FBC:GD An assay that characterizes the genome's DNase hypersensitivity using high-throughput sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003058 DNase-Seq FBcv:0003058 An assay that characterizes the genome's DNase hypersensitivity using high-throughput sequencing. FBC:GD An assay that characterizes transcriptional regulatory elements using formaldehyde-assisted isolation of regulatory elements (FAIRE) and high-throughput sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003059 FAIRE-Seq FBcv:0003059 An assay that characterizes transcriptional regulatory elements using formaldehyde-assisted isolation of regulatory elements (FAIRE) and high-throughput sequencing. FBC:GD An assay that maps the genome-wide position, orientation and amount of transcriptionally engaged RNA polymerase by global run-on sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003060 GRO-Seq FBcv:0003060 An assay that maps the genome-wide position, orientation and amount of transcriptionally engaged RNA polymerase by global run-on sequencing. PMID:19056941 An assay that maps nucleosome positions by using micrococcal nuclease to cleave linker DNA with the subsequent isolation of mononucleosomal DNA fragments that are characterized by genome tiling array. 2016-02-24T19:19:21Z assay_type FBcv:0003061 MNase-chip FBcv:0003061 An assay that maps nucleosome positions by using micrococcal nuclease to cleave linker DNA with the subsequent isolation of mononucleosomal DNA fragments that are characterized by genome tiling array. FBC:GD An assay that maps nucleosome positions by using micrococcal nuclease to cleave linker DNA with the subsequent isolation of mononucleosomal DNA fragments that are characterized by high-throughput sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003062 MNase-Seq FBcv:0003062 An assay that maps nucleosome positions by using micrococcal nuclease to cleave linker DNA with the subsequent isolation of mononucleosomal DNA fragments that are characterized by high-throughput sequencing. FBC:GD An assay of 5'-capped transcripts using the orthogonal approaches of reverse transcriptase template-switching and cap-trapping, with subsequent characterization by high-throughput sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003063 RAMPAGE-Seq FBcv:0003063 An assay of 5'-capped transcripts using the orthogonal approaches of reverse transcriptase template-switching and cap-trapping, with subsequent characterization by high-throughput sequencing. PMID:22936248 An assay mapping genomic replication patterns by labeling newly synthesized DNA in vivo with 5-bromo-2-deoxyuridine (BrdU), with subsequent affinity purification and characterization by high-throughput sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003064 Repli-Seq FBcv:0003064 An assay mapping genomic replication patterns by labeling newly synthesized DNA in vivo with 5-bromo-2-deoxyuridine (BrdU), with subsequent affinity purification and characterization by high-throughput sequencing. PMID:19966280 Ribosome profiling, an assay in which mRNA fragments protected by ribosomes are isolated and characterized by high-throughput sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003065 Ribo-Seq FBcv:0003065 Ribosome profiling, an assay in which mRNA fragments protected by ribosomes are isolated and characterized by high-throughput sequencing. PMID:22056041 An assay in which a factor is immunoprecipitated and the associated RNA sequences are characterized by high-throughput sequencing. 2016-02-24T19:19:21Z assay_type FBcv:0003066 RIP-Seq FBcv:0003066 An assay in which a factor is immunoprecipitated and the associated RNA sequences are characterized by high-throughput sequencing. PMID:21051541 Measurement of global transcript abundance by hybridization of cDNA to an oligonucleotide array, in which the array contains a set of probes designed with complementarity to each annotated transcript. 2016-02-24T19:19:21Z assay_type FBcv:0003067 RNA expression microarray FBcv:0003067 Measurement of global transcript abundance by hybridization of cDNA to an oligonucleotide array, in which the array contains a set of probes designed with complementarity to each annotated transcript. FBC:GD A quantitative method for mapping transcribed regions, in which complementary DNA fragments are subjected to high-throughput sequencing. 2016-02-24T19:19:21Z EFO:0008896 assay_type FBcv:0003068 RNA-Seq FBcv:0003068 A quantitative method for mapping transcribed regions, in which complementary DNA fragments are subjected to high-throughput sequencing. PMID:18451266 Measurement of transcribed regions across the genome by hybridization of cDNA to an oligonucleotide array, in which the genome is represented by oligonucleotides at regularly spaced intervals. 2016-02-24T19:19:21Z assay_type FBcv:0003069 RNA tiling array FBcv:0003069 Measurement of transcribed regions across the genome by hybridization of cDNA to an oligonucleotide array, in which the genome is represented by oligonucleotides at regularly spaced intervals. FBC:GD An assay characterizing of small RNA species 17-35 nt in size by high-throughput sequencing. 2016-02-24T19:19:21Z EFO:0008947 assay_type FBcv:0003070 short RNA-Seq FBcv:0003070 An assay characterizing of small RNA species 17-35 nt in size by high-throughput sequencing. FBC:GD An assay that identifies and characterizes of proteins and their post-translational modifications by mass spectrometry. 2016-02-24T19:19:21Z assay_type FBcv:0003071 protein mass spectrometry FBcv:0003071 An assay that identifies and characterizes of proteins and their post-translational modifications by mass spectrometry. FBC:GD An assay that identifies and characterizes lipids by mass spectrometry. 2016-02-24T19:19:21Z assay_type FBcv:0003072 lipid mass spectrometry FBcv:0003072 An assay that identifies and characterizes lipids by mass spectrometry. FBC:GD An assay that identifies and characterizes complex carbohydrates by mass spectrometry. 2016-02-24T19:19:21Z assay_type FBcv:0003073 carbohydrate mass spectrometry FBcv:0003073 An assay that identifies and characterizes complex carbohydrates by mass spectrometry. FBC:GD An assay that identifies and characterizes small metabolites by mass spectrometry. 2016-02-24T19:19:21Z assay_type FBcv:0003074 metabolite mass spectrometry FBcv:0003074 An assay that identifies and characterizes small metabolites by mass spectrometry. FBC:GD An assay that identifies the molecules that interact with a particular bait factor by mass spectrometry. 2016-02-24T19:19:21Z assay_type FBcv:0003075 affinity purification and mass spectrometry FBcv:0003075 An assay that identifies the molecules that interact with a particular bait factor by mass spectrometry. FBC:GD An assay that tests proteins pairwise for interaction by fusing each to separate, complementary domains of some protein, usually a transcription factor. Upon interaction, the proximity of the complementary domains generates reporter activity. 2016-02-24T19:19:21Z assay_type FBcv:0003076 two hybrid screen FBcv:0003076 An assay that tests proteins pairwise for interaction by fusing each to separate, complementary domains of some protein, usually a transcription factor. Upon interaction, the proximity of the complementary domains generates reporter activity. FBC:GD An assay that uses a panel of RNA interference (RNAi) reagents to systematically knockdown a large set of genes, one at a time, to identify those that are involved in some biological process. 2016-02-24T19:19:21Z assay_type FBcv:0003077 RNAi screen FBcv:0003077 An assay that uses a panel of RNA interference (RNAi) reagents to systematically knockdown a large set of genes, one at a time, to identify those that are involved in some biological process. FBC:GD An assay that uses a panel of deficiencies to systematically delete large segments of the genome to identify those segments that are involved in some biological process. 2016-02-24T19:19:21Z assay_type FBcv:0003078 deficiency screen FBcv:0003078 An assay that uses a panel of deficiencies to systematically delete large segments of the genome to identify those segments that are involved in some biological process. FBC:GD An assay that uses a large set of mutations to identify genes that are involved in some biological process. 2016-02-24T19:19:21Z assay_type FBcv:0003079 genetic screen FBcv:0003079 An assay that uses a large set of mutations to identify genes that are involved in some biological process. FBC:GD An assay that characterizes copy number variation of the genome in a sample using genome tiling array. 2016-02-24T19:19:21Z assay_type FBcv:0003080 comparative genomic hybridization by array FBcv:0003080 An assay that characterizes copy number variation of the genome in a sample using genome tiling array. FBC:GD An assay of genomic sequence that generates a large number of random genomic sequences, typically derived from paired-end sequencing of genomic fragments, that together give a complete (albeit scrambled) representation of the entire genome. 2016-02-24T19:19:21Z assay_type FBcv:0003081 whole genome shotgun sequencing FBcv:0003081 An assay of genomic sequence that generates a large number of random genomic sequences, typically derived from paired-end sequencing of genomic fragments, that together give a complete (albeit scrambled) representation of the entire genome. FBC:GD The type of result as characterized by its data content. 2016-02-24T19:19:21Z result_type FBcv:0003082 result type FBcv:0003082 The type of result as characterized by its data content. FBC:GD A result that maps the relative position of genetic markers, where distances are measured by recombination frequency. 2016-02-24T19:19:21Z result_type FBcv:0003083 genetic map FBcv:0003083 A result that maps the relative position of genetic markers, where distances are measured by recombination frequency. FBC:GD A result that maps the relative position of genes and other sequence landmarks. 2016-02-24T19:19:21Z result_type FBcv:0003084 physical map FBcv:0003084 A result that maps the relative position of genes and other sequence landmarks. FBC:GD A result in which a collection of whole genome shotgun sequences is combined to build successively larger contigs. 2016-02-24T19:19:21Z result_type FBcv:0003085 whole genome shotgun assembly FBcv:0003085 A result in which a collection of whole genome shotgun sequences is combined to build successively larger contigs. FBC:GD The result of reconstruction of the genome achieved by aligning and merging smaller fragments. 2016-02-24T19:19:21Z result_type FBcv:0003086 genome assembly FBcv:0003086 The result of reconstruction of the genome achieved by aligning and merging smaller fragments. FBC:GD The result of extensive sequence alignment and merging to produce a genome assembly that serves as the current reference for a particular organism. 2016-02-24T19:19:21Z result_type FBcv:0003087 reference genome assembly FBcv:0003087 The result of extensive sequence alignment and merging to produce a genome assembly that serves as the current reference for a particular organism. FBC:GD A result that provides the expression values for all (or some subset) of genes in a given biological sample. 2016-02-24T19:19:21Z result_type FBcv:0003088 gene expression profile FBcv:0003088 A result that provides the expression values for all (or some subset) of genes in a given biological sample. FBC:GD A result that profiles expressed RNA-seq sequences along genome. 2016-02-24T19:19:21Z result_type FBcv:0003089 RNA-seq profile FBcv:0003089 A result that profiles expressed RNA-seq sequences along genome. FBC:GD A result that profiles the genome occupancy for some factor. 2016-02-24T19:19:21Z result_type FBcv:0003090 genome binding profile FBcv:0003090 A result that profiles the genome occupancy for some factor. FBC:GD A result of Ribo-seq analysis that profiles ribosome protected sequences along the genome. 2016-02-24T19:19:21Z result_type FBcv:0003091 mRNA translation profile FBcv:0003091 A result of Ribo-seq analysis that profiles ribosome protected sequences along the genome. FBC:GD An analysis that results in the identification of discrete transcription start site regions. 2016-02-24T19:19:21Z result_type FBcv:0003092 TSS identification FBcv:0003092 An analysis that results in the identification of discrete transcription start site regions. FBC:GD An analysis that results in the identification of discrete polyadenylation sites. 2016-02-24T19:19:21Z result_type FBcv:0003093 poly(A) site identification FBcv:0003093 An analysis that results in the identification of discrete polyadenylation sites. FBC:GD An analysis that results in the identification of discrete exon junctions. 2016-02-24T19:19:21Z result_type FBcv:0003094 exon junction identification FBcv:0003094 An analysis that results in the identification of discrete exon junctions. FBC:GD An analysis that results in the identification of discrete A-to-I RNA editing sites. 2016-02-24T19:19:21Z result_type FBcv:0003095 editing site identification FBcv:0003095 An analysis that results in the identification of discrete A-to-I RNA editing sites. FBC:GD An analysis that results in the identification of discrete DNA or RNA binding sites. 2016-02-24T19:19:21Z result_type FBcv:0003096 binding site identification FBcv:0003096 An analysis that results in the identification of discrete DNA or RNA binding sites. FBC:GD An analysis that results from the comparison of expression profiles for different conditions to identify genes that are regulated by those conditions. 2016-02-24T19:19:21Z result_type FBcv:0003097 differential gene expression analysis FBcv:0003097 An analysis that results from the comparison of expression profiles for different conditions to identify genes that are regulated by those conditions. FBC:GD The analysis of a gene expression profiles to define sets of genes that share similar expression characteristics. 2016-02-24T19:19:21Z result_type FBcv:0003098 expression clustering FBcv:0003098 The analysis of a gene expression profiles to define sets of genes that share similar expression characteristics. FBC:GD A result that represents a set of genes that share similar expression characteristics across some set of conditions. 2016-02-24T19:19:21Z result_type FBcv:0003099 expression cluster FBcv:0003099 A result that represents a set of genes that share similar expression characteristics across some set of conditions. FBC:GD A result that represents a set of genes that have some shared characteristic. 2016-02-24T19:19:21Z result_type FBcv:0003100 gene list FBcv:0003100 A result that represents a set of genes that have some shared characteristic. FBC:GD A result that represents a set of protein-protein interactions for a given sample. 2016-02-24T19:19:21Z result_type FBcv:0003101 protein-protein interaction FBcv:0003101 A result that represents a set of protein-protein interactions for a given sample. FBC:GD A result that represents a set of RNA-protein interactions for a given sample. 2016-02-24T19:19:21Z result_type FBcv:0003102 RNA-protein interaction FBcv:0003102 A result that represents a set of RNA-protein interactions for a given sample. FBC:GD A result that represents a set of RNA-RNA interactions for a given sample. 2016-02-24T19:19:21Z result_type FBcv:0003103 RNA-RNA interaction FBcv:0003103 A result that represents a set of RNA-RNA interactions for a given sample. FBC:GD A result that represents a set of small molecules identified for a given sample. 2016-02-24T19:19:21Z result_type FBcv:0003104 metabolite profile FBcv:0003104 A result that represents a set of small molecules identified for a given sample. FBC:GD A result that represents the range of phenotypes obtained for a set of genetic perturbations. 2016-02-24T19:19:21Z result_type FBcv:0003105 phenotypic profile FBcv:0003105 A result that represents the range of phenotypes obtained for a set of genetic perturbations. FBC:GD A result that represents the copy number variation across the genome for a given sample. 2016-02-24T19:19:21Z result_type FBcv:0003106 genomic copy number profile FBcv:0003106 A result that represents the copy number variation across the genome for a given sample. FBC:GD A result that represents the mapping of coordinates between two different genome assemblies for a given species. 2016-02-24T19:19:21Z result_type FBcv:0003107 liftover file FBcv:0003107 A result that represents the mapping of coordinates between two different genome assemblies for a given species. FBC:GD A result that is produced from the detailed examination of data to come to some conclusion. 2016-02-24T19:19:21Z result_type FBcv:0003108 analysis FBcv:0003108 A result that is produced from the detailed examination of data to come to some conclusion. FBC:GD The type of reagent collection as characterized by the material resources comprised by the collection. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003109 reagent collection type FBcv:0003109 The type of reagent collection as characterized by the material resources comprised by the collection. FBC:GD A collection of large chromosomal aberrations, available as fly stocks, which may include duplications, deletions, inversions or translocations. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003110 aberration stock collection FBcv:0003110 A collection of large chromosomal aberrations, available as fly stocks, which may include duplications, deletions, inversions or translocations. FBC:GD A collection of alleles that are available as fly stocks. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003111 allele collection FBcv:0003111 A collection of alleles that are available as fly stocks. FBC:GD A collection of cDNAs available as plasmids. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003112 cDNA library FBcv:0003112 A collection of cDNAs available as plasmids. FBC:GD A collection of transgenic constructs that are available as fly stocks. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003113 construct collection FBcv:0003113 A collection of transgenic constructs that are available as fly stocks. FBC:GD A collection of PCR products used for the synthesis of double-stranded RNA to induce RNA-interference. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003114 dsRNA amplicon collection FBcv:0003114 A collection of PCR products used for the synthesis of double-stranded RNA to induce RNA-interference. FBC:GD A collection of transgenic constructs, available as fly stocks, designed to target gene knockdown by RNA-interference. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003115 RNAi construct collection FBcv:0003115 A collection of transgenic constructs, available as fly stocks, designed to target gene knockdown by RNA-interference. FBC:GD A collection of genomic DNA clones available as plasmids. This may include BAC, YAC, fosmid, cosmid and P1 clone collections. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003116 genomic clone collection FBcv:0003116 A collection of genomic DNA clones available as plasmids. This may include BAC, YAC, fosmid, cosmid and P1 clone collections. FBC:GD A collection of wild-type fly strains. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003117 fly strain collection FBcv:0003117 A collection of wild-type fly strains. FBC:GD A collection of transgenic construct insertions available as fly stocks. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003118 transgenic insertion collection FBcv:0003118 A collection of transgenic construct insertions available as fly stocks. FBC:GD A collection of transposable element insertions available as fly stocks. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003119 TE insertion stock collection FBcv:0003119 A collection of transposable element insertions available as fly stocks. FBC:GD A collection of hybridization targets on a microarray. 2016-02-24T19:19:21Z reagent_collection_type FBcv:0003120 microarray library FBcv:0003120 A collection of hybridization targets on a microarray. FBC:GD A descriptor that describes some aspect of a dataset. 2016-02-24T19:19:21Z FlyBase miscellaneous CV FBcv:0003121 dataset attribute FBcv:0003121 A descriptor that describes some aspect of a dataset. FBC:GD A descriptor that describes some aspect of a project. 2016-02-24T19:19:21Z project_attribute FBcv:0003122 project attribute FBcv:0003122 A descriptor that describes some aspect of a project. FBC:GD The aim of the project investigation, as defined by the key variables in the set of experiments. 2016-02-24T19:19:21Z project_attribute FBcv:0003123 study design FBcv:0003123 The aim of the project investigation, as defined by the key variables in the set of experiments. FBC:GD A project study design that aims to compare different species. 2016-02-24T19:19:21Z project_attribute FBcv:0003124 species study FBcv:0003124 A project study design that aims to compare different species. FBC:GD A project study design that aims to compare different wild-type strains for a given species. 2016-02-24T19:19:21Z project_attribute FBcv:0003125 strain study FBcv:0003125 A project study design that aims to compare different wild-type strains for a given species. FBC:GD A project study design that aims to characterize the biological mechanisms responsible for the development or maintenance of the sex-related properties of an organism. 2016-02-24T19:19:21Z project_attribute FBcv:0003126 sex study FBcv:0003126 A project study design that aims to characterize the biological mechanisms responsible for the development or maintenance of the sex-related properties of an organism. FBC:CT A project study design investigating the biological mechanisms responsible for the control or maintenance of development. 2016-02-24T19:19:21Z project_attribute FBcv:0003127 developmental stage study FBcv:0003127 A project study design investigating the biological mechanisms responsible for the control or maintenance of development. FBC:CT A project study design investigating the biological mechanisms responsible for the control or maintenance of circadian rhythm. 2016-02-24T19:19:21Z project_attribute FBcv:0003128 circadian rhythm study FBcv:0003128 A project study design investigating the biological mechanisms responsible for the control or maintenance of circadian rhythm. FBC:CT A project study design investigating the biological mechanisms of the cell responsible for maintaining or controlling aspects of the cell cycle. 2016-02-24T19:19:21Z project_attribute FBcv:0003129 cell cycle study FBcv:0003129 A project study design investigating the biological mechanisms of the cell responsible for maintaining or controlling aspects of the cell cycle. FBC:CT A project study design investigating the biological mechanisms of intact or dissected tissues in order to understand their form or function. 2016-02-24T19:19:21Z project_attribute FBcv:0003130 tissue type study FBcv:0003130 A project study design investigating the biological mechanisms of intact or dissected tissues in order to understand their form or function. FBC:CT A project study design involving the use of cultured or extracted cells with an investigative focus of studying a cellular property. 2016-02-24T19:19:21Z project_attribute FBcv:0003131 cell type study FBcv:0003131 A project study design involving the use of cultured or extracted cells with an investigative focus of studying a cellular property. FBC:CT A project study design examining subcellular components of cells including organelles, the nucleus, or any other grouping of intra- or extracellular material. 2016-02-24T19:19:21Z project_attribute FBcv:0003132 subcellular component study FBcv:0003132 A project study design examining subcellular components of cells including organelles, the nucleus, or any other grouping of intra- or extracellular material. FBC:CT A project study design in which the goal of the study is to examine properties of a specific gene or set of genes. 2016-02-24T19:19:21Z project_attribute FBcv:0003133 gene study FBcv:0003133 A project study design in which the goal of the study is to examine properties of a specific gene or set of genes. FBC:CT A project study design investigating the effects of a biotic stimulus on some aspect of an organism. 2016-02-24T19:19:21Z project_attribute FBcv:0003134 biotic stimulus study FBcv:0003134 A project study design investigating the effects of a biotic stimulus on some aspect of an organism. FBC:CT A project study design investigating the effects of a chemical stimulus on some aspect of an organism. 2016-02-24T19:19:21Z project_attribute FBcv:0003135 chemical stimulus study FBcv:0003135 A project study design investigating the effects of a chemical stimulus on some aspect of an organism. FBC:CT A project study design investigating the effects of a physical stimulus on some aspect of an organism. 2016-02-24T19:19:21Z project_attribute FBcv:0003136 physical stimulus study FBcv:0003136 A project study design investigating the effects of a physical stimulus on some aspect of an organism. FBC:CT Characteristics pertaining to the growth conditions, treatments and tissue isolation methods used to generate and obtain a biosample. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003137 biosample attribute FBcv:0003137 Characteristics pertaining to the growth conditions, treatments and tissue isolation methods used to generate and obtain a biosample. FBC:GD The scope and purity of a biosample, ranging from single cell to environmental sample. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003138 biosample scope FBcv:0003138 The scope and purity of a biosample, ranging from single cell to environmental sample. http://www.ncbi.nlm.nih.gov/books/NBK54364/ A biosample that is derived from only a single cell. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003139 single cell sample FBcv:0003139 A biosample that is derived from only a single cell. FBC:CT A biosample that is derived from one individual. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003140 single individual sample FBcv:0003140 A biosample that is derived from one individual. FBC:CT A biosample that is derived from multiple individuals. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003141 multi-individual sample FBcv:0003141 A biosample that is derived from multiple individuals. FBC:CT A biosample that is derived from multiple species. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003142 multispecies sample FBcv:0003142 A biosample that is derived from multiple species. FBC:CT A biosample derived from an environmental sample for which the species content is unknown. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003143 environmental FBcv:0003143 A biosample derived from an environmental sample for which the species content is unknown. http://www.ncbi.nlm.nih.gov/books/NBK54364/ A biosample that was synthesized in a laboratory. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003144 artificial FBcv:0003144 A biosample that was synthesized in a laboratory. http://www.ncbi.nlm.nih.gov/books/NBK54364/ A sample that originated from a wild caught population and is considered true wild type. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003145 wild caught FBcv:0003145 A sample that originated from a wild caught population and is considered true wild type. FBC:CT Growth conditions and treatments used to culture the organism prior to biosample isolation. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003146 growth condition FBcv:0003146 Growth conditions and treatments used to culture the organism prior to biosample isolation. FBC:GD An inbred strain is subjected to artificial laboratory selection of some trait over the course of several generations. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003147 trait selection FBcv:0003147 An inbred strain is subjected to artificial laboratory selection of some trait over the course of several generations. FBC:GD A sample that is derived from a controlled mating between individuals of two specific species. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003148 interspecific hybrid FBcv:0003148 A sample that is derived from a controlled mating between individuals of two specific species. FBC:CT A sample in which the individuals have undergone mating. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003149 mated FBcv:0003149 A sample in which the individuals have undergone mating. FBC:CT A sample in which the individuals have not undergone mating. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003150 virgin FBcv:0003150 A sample in which the individuals have not undergone mating. FBC:CT A sample that is maintained in conditions comparable to constant darkness. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003151 constant dark FBcv:0003151 A sample that is maintained in conditions comparable to constant darkness. FBC:CT A sample that is maintained in conditions comparable to constant light. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003152 constant light FBcv:0003152 A sample that is maintained in conditions comparable to constant light. FBC:CT A sample that is maintained in conditions with a specific cycle that included exposure to both light and darkness. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003153 light-dark cycle FBcv:0003153 A sample that is maintained in conditions with a specific cycle that included exposure to both light and darkness. FBC:CT A sample that is derived from a primary cell culture. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003154 primary cell culture FBcv:0003154 A sample that is derived from a primary cell culture. FBC:CT Characteristics pertaining to the cell culture conditions used to generate the biosample. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003155 cell culture property FBcv:0003155 Characteristics pertaining to the cell culture conditions used to generate the biosample. FBC:GD A sample that contains a transfected agent which is not incorporated into the genome. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003156 transiently transfected cell line FBcv:0003156 A sample that contains a transfected agent which is not incorporated into the genome. FBC:CT A sample that contains a transfected agent which has been stably incorporated into the genome. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003157 stably transfected cell line FBcv:0003157 A sample that contains a transfected agent which has been stably incorporated into the genome. FBC:CT A sample that is derived from a population of cells undergoing a log phase of division. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003158 log phase cells FBcv:0003158 A sample that is derived from a population of cells undergoing a log phase of division. FBC:CT A sample that is derived from a population of cells undergoing a stationary phase of division. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003159 stationary phase cells FBcv:0003159 A sample that is derived from a population of cells undergoing a stationary phase of division. FBC:CT A sample that is derived from a population of cells undergoing cell cycle division in a synchronized manner. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003160 cell cycle synchronized cells FBcv:0003160 A sample that is derived from a population of cells undergoing cell cycle division in a synchronized manner. FBC:CT The cells that are grown in liquid culture. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003161 suspension culture FBcv:0003161 The cells that are grown in liquid culture. FBC:GD The cells that are grown on plates. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003162 adherent culture FBcv:0003162 The cells that are grown on plates. FBC:GD The conditioned medium containing factors secreted by cultured cells that has been isolated. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003163 culture supernatant FBcv:0003163 The conditioned medium containing factors secreted by cultured cells that has been isolated. FBC:GD Methods pertaining to the experimental treatment or isolation of a biosample. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003164 biosample method FBcv:0003164 Methods pertaining to the experimental treatment or isolation of a biosample. FBC:GD A sample that has undergone a disruption to the activity of one of its genes. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003165 gene perturbation FBcv:0003165 A sample that has undergone a disruption to the activity of one of its genes. FBC:GD Treatment of an organism with a biological stimulus, such as an infectious or parasitic agent. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003166 biotic treatment FBcv:0003166 Treatment of an organism with a biological stimulus, such as an infectious or parasitic agent. FBC:GD A sample that has been exposed to one or more forms of chemical agent. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003167 chemical treatment FBcv:0003167 A sample that has been exposed to one or more forms of chemical agent. FBC:CT A sample that has been exposed to changes in the physical environment including temperature, pressure and radiation. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003168 physical treatment FBcv:0003168 A sample that has been exposed to changes in the physical environment including temperature, pressure and radiation. FBC:GD A sample that has been dissected from the tissue of a more complete organism. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003169 tissue dissection FBcv:0003169 A sample that has been dissected from the tissue of a more complete organism. FBC:CT A single cell type that has been isolated by affinity purification or fluorescent cell sorting. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003170 cell isolation FBcv:0003170 A single cell type that has been isolated by affinity purification or fluorescent cell sorting. FBC:GD A sample that has undergone fractionation in order to isolate specific subcellular components for study. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003171 subcellular fractionation FBcv:0003171 A sample that has undergone fractionation in order to isolate specific subcellular components for study. FBC:CT A sample in which specific cells within a tissue have been ablated by some method, such as targeted expression of a cell toxin, or laser ablation of fluorescently marked cells. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003172 cell ablation FBcv:0003172 A sample in which specific cells within a tissue have been ablated by some method, such as targeted expression of a cell toxin, or laser ablation of fluorescently marked cells. FBC:GD A sample that has been labelled in a targeted, cell-specific manner. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003173 targeted cell labeling FBcv:0003173 A sample that has been labelled in a targeted, cell-specific manner. FBC:CT Neuronal activity that has been perturbed using genetically controlled agents to activate or depress membrane potential. 2016-02-24T19:19:21Z biosample_attribute FBcv:0003174 neuronal activity perturbation FBcv:0003174 Neuronal activity that has been perturbed using genetically controlled agents to activate or depress membrane potential. FBC:GD Some characteristic of an assay pertaining to the methods involved in processing the biological source material or generating the raw output data of the assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003175 assay attribute FBcv:0003175 Some characteristic of an assay pertaining to the methods involved in processing the biological source material or generating the raw output data of the assay. FBC:GD A type of biomolecule that is isolated from a biosample and characterized by downstream steps in an assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003176 assay material FBcv:0003176 A type of biomolecule that is isolated from a biosample and characterized by downstream steps in an assay. FBC:GD Material that is derived from isolation of genomic DNA. 2016-02-24T19:19:21Z assay_attribute FBcv:0003177 genomic DNA isolation FBcv:0003177 Material that is derived from isolation of genomic DNA. FBC:CT Material that is derived from isolation of the total RNA. 2016-02-24T19:19:21Z assay_attribute FBcv:0003178 total RNA isolation FBcv:0003178 Material that is derived from isolation of the total RNA. FBC:CT Material that is derived from the isolation of RNA containing a poly(A) tail. 2016-02-24T19:19:21Z assay_attribute FBcv:0003179 poly(A) RNA isolation FBcv:0003179 Material that is derived from the isolation of RNA containing a poly(A) tail. FBC:CT The isolation of small RNA species 17-35 nt in size. 2016-02-24T19:19:21Z assay_attribute FBcv:0003180 short RNA isolation FBcv:0003180 The isolation of small RNA species 17-35 nt in size. FBC:GD Material that is derived from the isolation of translated messenger RNA. 2016-02-24T19:19:21Z assay_attribute FBcv:0003181 translated mRNA isolation FBcv:0003181 Material that is derived from the isolation of translated messenger RNA. FBC:CT Material that is derived from the isolation of proteins. 2016-02-24T19:19:21Z assay_attribute FBcv:0003182 protein isolation FBcv:0003182 Material that is derived from the isolation of proteins. FBC:CT Material that is derived from the isolation of chromatin and its subcellular components and/or binding partners. 2016-02-24T19:19:21Z assay_attribute FBcv:0003183 chromatin isolation FBcv:0003183 Material that is derived from the isolation of chromatin and its subcellular components and/or binding partners. FBC:CT Isolation of RNA-protein complexes. 2016-02-24T19:19:21Z assay_attribute FBcv:0003184 RNA-protein isolation FBcv:0003184 Isolation of RNA-protein complexes. FBC:GD Material that is derived from the isolation of metabolites. 2016-02-24T19:19:21Z assay_attribute FBcv:0003185 metabolite isolation FBcv:0003185 Material that is derived from the isolation of metabolites. FBC:CT The biosample that is depleted of specific biomolecule types before further processing. 2016-02-24T19:19:21Z assay_attribute FBcv:0003186 assay material depletion FBcv:0003186 The biosample that is depleted of specific biomolecule types before further processing. FBC:GD Material that has undergone the depletion of ribosomal RNA. 2016-02-24T19:19:21Z assay_attribute FBcv:0003187 rRNA depletion FBcv:0003187 Material that has undergone the depletion of ribosomal RNA. FBC:CT Material that has undergone the depletion of single-stranded RNA. 2016-02-24T19:19:21Z assay_attribute FBcv:0003188 ssRNA depletion FBcv:0003188 Material that has undergone the depletion of single-stranded RNA. FBC:CT Material that has undergone the depletion of double-stranded RNA. 2016-02-24T19:19:21Z assay_attribute FBcv:0003189 dsRNA depletion FBcv:0003189 Material that has undergone the depletion of double-stranded RNA. FBC:CT Material that has undergone the depletion of unbound RNA. 2016-02-24T19:19:21Z assay_attribute FBcv:0003190 unbound RNA depletion FBcv:0003190 Material that has undergone the depletion of unbound RNA. FBC:CT The biosample that is enriched for a specific biomolecule type for further processing. 2016-02-24T19:19:21Z assay_attribute FBcv:0003191 assay material selection FBcv:0003191 The biosample that is enriched for a specific biomolecule type for further processing. FBC:GD Material that has been selected using Chromatin Immunoprecipitation, or ChIP. 2016-02-24T19:19:21Z assay_attribute FBcv:0003192 ChIP FBcv:0003192 Material that has been selected using Chromatin Immunoprecipitation, or ChIP. FBC:CT Material that has been selected using DNA Adenine Methyltransferase Identification, or DamID. 2016-02-24T19:19:21Z assay_attribute FBcv:0003193 DamID FBcv:0003193 Material that has been selected using DNA Adenine Methyltransferase Identification, or DamID. FBC:CT Material that has been selected using formaldehyde-assisted isolation of Regulatory Elements or FAIRE. 2016-02-24T19:19:21Z assay_attribute FBcv:0003194 FAIRE FBcv:0003194 Material that has been selected using formaldehyde-assisted isolation of Regulatory Elements or FAIRE. FBC:CT Material that has been selected using Cap Analysis Gene Expression, in which the 7-methylguanosine cap at 5' transcript ends is biotinylated and affinity purified. 2016-02-24T19:19:21Z assay_attribute FBcv:0003195 CAGE FBcv:0003195 Material that has been selected using Cap Analysis Gene Expression, in which the 7-methylguanosine cap at 5' transcript ends is biotinylated and affinity purified. PMID:16489339 Chromatin that has been cleaved using micrococcal nuclease to cleave at linker DNA between nucleosomes. 2016-02-24T19:19:21Z assay_attribute FBcv:0003196 MNase FBcv:0003196 Chromatin that has been cleaved using micrococcal nuclease to cleave at linker DNA between nucleosomes. FBC:GD Material that has been selected from a sample treated by deoxyribonuclease. 2016-02-24T19:19:21Z assay_attribute FBcv:0003197 DNase FBcv:0003197 Material that has been selected from a sample treated by deoxyribonuclease. FBC:CT Material that has been selected using a low salt chromatin extraction, typically 80mM. 2016-02-24T19:19:21Z assay_attribute FBcv:0003198 low salt chromatin extraction FBcv:0003198 Material that has been selected using a low salt chromatin extraction, typically 80mM. FBC:CT Material that has been selected using a high salt chromatin extraction, typically 600mM. 2016-02-24T19:19:21Z assay_attribute FBcv:0003199 high salt chromatin extraction FBcv:0003199 Material that has been selected using a high salt chromatin extraction, typically 600mM. FBC:CT Mononucleosomal fragments, generated by micrococcal nuclease cleavage at linker DNA between nucleosomes, that have been isolated by gel electrophoresis. 2016-02-24T19:19:21Z assay_attribute FBcv:0003200 mononucleosomal DNA isolation FBcv:0003200 Mononucleosomal fragments, generated by micrococcal nuclease cleavage at linker DNA between nucleosomes, that have been isolated by gel electrophoresis. FBC:GD Material that has been selected using affinity purification. 2016-02-24T19:19:21Z assay_attribute FBcv:0003201 affinity purification FBcv:0003201 Material that has been selected using affinity purification. FBC:CT Material that has been selected using size fractionation. 2016-02-24T19:19:21Z assay_attribute FBcv:0003202 size fractionation FBcv:0003202 Material that has been selected using size fractionation. FBC:CT Material that has been selected using short sequences of deoxy-thymine nucleotides to affinity purify RNA containing long polyA stretches. 2016-02-24T19:19:21Z assay_attribute FBcv:0003203 oligo-dT selection FBcv:0003203 Material that has been selected using short sequences of deoxy-thymine nucleotides to affinity purify RNA containing long polyA stretches. FBC:CT Material that has been selected using short sequences of deoxy-thymine nucleotides to prime first strand cDNA synthesis by reverse transcriptase at long polyA stretches. 2016-02-24T19:19:21Z assay_attribute FBcv:0003204 oligo-dT priming FBcv:0003204 Material that has been selected using short sequences of deoxy-thymine nucleotides to prime first strand cDNA synthesis by reverse transcriptase at long polyA stretches. FBC:CT Random oligomers that have been used to prime first strand cDNA synthesis by reverse transcriptase at random positions along transcripts. 2016-02-24T19:19:21Z assay_attribute FBcv:0003205 random priming FBcv:0003205 Random oligomers that have been used to prime first strand cDNA synthesis by reverse transcriptase at random positions along transcripts. FBC:GD Material that has been selected based on density via density sedimentation. 2016-02-24T19:19:21Z assay_attribute FBcv:0003206 density sedimentation FBcv:0003206 Material that has been selected based on density via density sedimentation. FBC:CT Nucleotide analogs that are used to map the position and orientation of the RNA polymerase active site. 2016-02-24T19:19:21Z assay_attribute FBcv:0003207 nuclear run-on FBcv:0003207 Nucleotide analogs that are used to map the position and orientation of the RNA polymerase active site. FBC:GD A method used to characterize the biological molecules isolated from a biosample. 2016-02-24T19:19:21Z assay_attribute FBcv:0003208 assay method FBcv:0003208 A method used to characterize the biological molecules isolated from a biosample. FBC:GD A method that uses Sanger sequencing for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003209 Sanger sequencing FBcv:0003209 A method that uses Sanger sequencing for this assay. FBC:CT A method that uses single molecule sequencing, by highly processive DNA polymerase to generate an extremely long single read on the order of several kilobases, for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003210 single molecule real time sequencing FBcv:0003210 A method that uses single molecule sequencing, by highly processive DNA polymerase to generate an extremely long single read on the order of several kilobases, for this assay. FBC:GD A method that uses high-throughput sequencing for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003211 high-throughput sequencing FBcv:0003211 A method that uses high-throughput sequencing for this assay. FBC:CT A method that uses 454 sequencing, a form of high-throughput sequencing with 400-500 nt read length, for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003212 454 sequencing FBcv:0003212 A method that uses 454 sequencing, a form of high-throughput sequencing with 400-500 nt read length, for this assay. FBC:CT A method that uses Illumina sequencing, a form of high-throughput sequencing, for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003213 Illumina sequencing FBcv:0003213 A method that uses Illumina sequencing, a form of high-throughput sequencing, for this assay. FBC:CT A method that uses an Affymetrix Gene Expression Array, version 1, for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003214 Affymetrix Gene Expression Array 1 FBcv:0003214 A method that uses an Affymetrix Gene Expression Array, version 1, for this assay. FBC:CT FBC:GD A method that uses an Affymetrix Gene Expression Array, version 2, for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003215 Affymetrix Gene Expression Array 2 FBcv:0003215 A method that uses an Affymetrix Gene Expression Array, version 2, for this assay. FBC:CT A method that uses a genomic tiling array, a subtype of microarray chip in which the genome is represented by oligonucleotides at regularly spaced intervals, for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003216 genomic tiling array FBcv:0003216 A method that uses a genomic tiling array, a subtype of microarray chip in which the genome is represented by oligonucleotides at regularly spaced intervals, for this assay. FBC:CT A method that uses a peptide array, a subtype of microarray chip, for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003217 peptide array FBcv:0003217 A method that uses a peptide array, a subtype of microarray chip, for this assay. FBC:CT A method that uses mass spectrometry, an analytical technique for sorting ions based on mass, for this assay. 2016-02-24T19:19:21Z assay_attribute FBcv:0003218 mass spectrometry FBcv:0003218 A method that uses mass spectrometry, an analytical technique for sorting ions based on mass, for this assay. FBC:CT A method that uses two samples, one a control and the other an experimental sample, for this assay. The samples are labeled in different colors and hybridized to the same oligonucleotide array. Each sample is scanned using different excitation and emission parameters. 2016-02-24T19:19:21Z assay_attribute FBcv:0003219 two channel scanning FBcv:0003219 A method that uses two samples, one a control and the other an experimental sample, for this assay. The samples are labeled in different colors and hybridized to the same oligonucleotide array. Each sample is scanned using different excitation and emission parameters. FBC:GD A method that uses an RNA-seq assay in which only one end of the library fragment is sequenced. 2016-02-24T19:19:21Z assay_attribute FBcv:0003220 single-end layout FBcv:0003220 A method that uses an RNA-seq assay in which only one end of the library fragment is sequenced. FBC:GD A method that uses an RNA-seq assay in which both ends of the library fragment are sequenced to provide additional mapping constraints. 2016-02-24T19:19:21Z assay_attribute FBcv:0003221 paired-end layout FBcv:0003221 A method that uses an RNA-seq assay in which both ends of the library fragment are sequenced to provide additional mapping constraints. FBC:GD Some characteristic of a result pertaining to the methods involved in analyzing the input data, or the content or format of the output data. 2016-02-24T19:19:21Z result_attribute FBcv:0003222 result attribute FBcv:0003222 Some characteristic of a result pertaining to the methods involved in analyzing the input data, or the content or format of the output data. FBC:GD A genomic mapping profile that distinguishes forward and reverse strand distributions. 2016-02-24T19:19:21Z result_attribute FBcv:0003223 stranded profile FBcv:0003223 A genomic mapping profile that distinguishes forward and reverse strand distributions. FBC:GD A genomic mapping profile that does not distinguish between forward and reverse strand mapping. 2016-02-24T19:19:21Z result_attribute FBcv:0003224 unstranded profile FBcv:0003224 A genomic mapping profile that does not distinguish between forward and reverse strand mapping. FBC:GD An alignment of high-throughput sequences that includes only those reads mapping uniquely to the genome. 2016-02-24T19:19:21Z result_attribute FBcv:0003225 uniquely mapping read alignment FBcv:0003225 An alignment of high-throughput sequences that includes only those reads mapping uniquely to the genome. FBC:GD An alignment of high-throughput sequences that includes reads mapping to multiple sites in the genome. Coverage values for a given sequence weighted equally across the multiple sites to which it maps. 2016-02-24T19:19:21Z result_attribute FBcv:0003226 multiply mapping read alignment FBcv:0003226 An alignment of high-throughput sequences that includes reads mapping to multiple sites in the genome. Coverage values for a given sequence weighted equally across the multiple sites to which it maps. FBC:GD A unit of expression (reads per kilobase per million reads) in which high-throughput sequencing reads mapping to a given feature are normalized both to the size of that feature and to the total number of reads in the sample. 2016-02-24T19:19:21Z result_attribute FBcv:0003227 RPKM calculation FBcv:0003227 A unit of expression (reads per kilobase per million reads) in which high-throughput sequencing reads mapping to a given feature are normalized both to the size of that feature and to the total number of reads in the sample. FBC:GD A unit of expression (reads per million miRNA reads) in which high-throughput sequencing reads for a given miRNA are normalized against all reads mapping to all miRNA. 2016-02-24T19:19:21Z result_attribute FBcv:0003228 RPMM calculation FBcv:0003228 A unit of expression (reads per million miRNA reads) in which high-throughput sequencing reads for a given miRNA are normalized against all reads mapping to all miRNA. FBC:GD A unit of expression (reads per million reads) in which high-throughput sequencing reads for a given type of feature are normalized against all reads mapping to all features of the same type. 2016-02-24T19:19:21Z result_attribute FBcv:0003229 RPM calculation FBcv:0003229 A unit of expression (reads per million reads) in which high-throughput sequencing reads for a given type of feature are normalized against all reads mapping to all features of the same type. FBC:GD Sequencing the full extent of selected large clones, typically by sub-cloning large inserts as smaller fragments, to improve the accuracy and completeness of an assembly. 2016-02-24T19:19:21Z result_attribute FBcv:0003230 clone-based finishing FBcv:0003230 Sequencing the full extent of selected large clones, typically by sub-cloning large inserts as smaller fragments, to improve the accuracy and completeness of an assembly. FlyBase:FBrf0155823 Mapping of restriction enzyme recognition sites to develop a physical map of a genome. 2016-02-24T19:19:21Z result_attribute FBcv:0003231 restriction fingerprinting FBcv:0003231 Mapping of restriction enzyme recognition sites to develop a physical map of a genome. FBC:GD Mapping of short (200-500 bp) sequence-tagged sites (STS) landmarks to develop a physical map of a genome. 2016-02-24T19:19:21Z result_attribute FBcv:0003232 sequence tagged site mapping FBcv:0003232 Mapping of short (200-500 bp) sequence-tagged sites (STS) landmarks to develop a physical map of a genome. FBC:GD An ordered list of a minimal set of overlapping clones that provides complete coverage across an assembly. 2016-02-24T19:19:21Z result_attribute FBcv:0003233 tiling path FBcv:0003233 An ordered list of a minimal set of overlapping clones that provides complete coverage across an assembly. FBC:GD Sequences that have been mapped to mitotic or polytene chromosomes to guide genome assembly. 2016-02-24T19:19:21Z result_attribute FBcv:0003234 cytogenetic mapping FBcv:0003234 Sequences that have been mapped to mitotic or polytene chromosomes to guide genome assembly. FBC:GD There is sequence for one or more chromosomes. This could be a completely sequenced chromosome without gaps or a chromosome containing scaffolds or contigs with gaps between them. There may also be unplaced or unlocalized scaffolds. 2016-02-24T19:19:21Z result_attribute FBcv:0003235 assembly level - chromosome FBcv:0003235 There is sequence for one or more chromosomes. This could be a completely sequenced chromosome without gaps or a chromosome containing scaffolds or contigs with gaps between them. There may also be unplaced or unlocalized scaffolds. http://www.ncbi.nlm.nih.gov/assembly/help/ Some sequence contigs have been connected across gaps to create scaffolds, but no scaffolds have been placed on chromosomes. 2016-02-24T19:19:21Z result_attribute FBcv:0003236 assembly level - scaffold FBcv:0003236 Some sequence contigs have been connected across gaps to create scaffolds, but no scaffolds have been placed on chromosomes. http://www.ncbi.nlm.nih.gov/assembly/help/ The assembly represents the whole genome, though there may still be gaps. 2016-02-24T19:19:21Z result_attribute FBcv:0003237 genome representation - full FBcv:0003237 The assembly represents the whole genome, though there may still be gaps. http://www.ncbi.nlm.nih.gov/assembly/help/ The assembly represents only part of the organism's genome, because only a single chromosome was targeted, coverage is <1, or total length is less than half the average for other assemblies of the same species. 2016-02-24T19:19:21Z result_attribute FBcv:0003238 genome representation - partial FBcv:0003238 The assembly represents only part of the organism's genome, because only a single chromosome was targeted, coverage is <1, or total length is less than half the average for other assemblies of the same species. http://www.ncbi.nlm.nih.gov/assembly/help/ Sequence change caused by the cleavage of specific DNA sequences by zinc finger nucleases (ZFNs). ZFN proteins comprise a DNA binding domain linked to the DNA cleavage domain of FokI endonuclease. The DNA binding domain is composed of three Cys2His2 zinc fingers, with each zinc finger contacting three consecutive base pairs of DNA. The specificity of the binding is determined by the sequence of the three-zinc finger DNA binding domain, which recognizes a 9 base pair sequence. Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of ZFNs which bind to sequences in close proximity, allowing dimerization and promoting cleavage. 2016-04-06T10:22:52Z change induced by zinc finger nuclease-mediated cleavage origin_of_mutation zinc finger nuclease FBcv:0003239 ZFN FBcv:0003239 Sequence change caused by the cleavage of specific DNA sequences by zinc finger nucleases (ZFNs). ZFN proteins comprise a DNA binding domain linked to the DNA cleavage domain of FokI endonuclease. The DNA binding domain is composed of three Cys2His2 zinc fingers, with each zinc finger contacting three consecutive base pairs of DNA. The specificity of the binding is determined by the sequence of the three-zinc finger DNA binding domain, which recognizes a 9 base pair sequence. Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of ZFNs which bind to sequences in close proximity, allowing dimerization and promoting cleavage. PMID:10954606 PMID:12730594 PMID:8577732 2016-05-17T15:35:41Z assay_attribute FBcv:0003240 expression array FBcv:0003240 Phenotype that is any abnormality in sensory perception of light stimulus (GO:0050953). 'sensory perception of light stimulus' is defined as: 'The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.' visual perception defective phenotypic_class FBcv:0004000 abnormal visual perception FBcv:0004000 Phenotype that is any abnormality in sensory perception of light stimulus (GO:0050953). 'sensory perception of light stimulus' is defined as: 'The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.' FBC:MMC GOC:ai Sequence change caused by a site specific recombination catalyzed by the serine recombinase Bxb1 integrase that recognizes a minimal high-efficiency attPX recognition site of 48 base pairs and a minimal high-efficiency attBX recognition site of 38 base pairs. The attPX and attBX sites share an 8bp common core flanked by imperfect inverted repeats (19bp in attPX and 8bp in attBX). A non-palindromic central dinucleotide (5'-GT) determines the directionality of integration. 2017-06-12T10:56:07Z change induced by Bxb1 integrase recombination origin_of_mutation FBcv:0005000 Bxb1 integrase FBcv:0005000 Sequence change caused by a site specific recombination catalyzed by the serine recombinase Bxb1 integrase that recognizes a minimal high-efficiency attPX recognition site of 48 base pairs and a minimal high-efficiency attBX recognition site of 38 base pairs. The attPX and attBX sites share an 8bp common core flanked by imperfect inverted repeats (19bp in attPX and 8bp in attBX). A non-palindromic central dinucleotide (5'-GT) determines the directionality of integration. PMID:14636570 Term that describes the use of an experimental tool. 2017-06-28T11:41:27Z FlyBase miscellaneous CV FBcv:0005001 experimental tool descriptor FBcv:0005001 Term that describes the use of an experimental tool. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that gene product by an experimental method. 2017-06-28T11:41:27Z experimental_tool_descriptor gene product detection tag FBcv:0005002 gene product detection tool FBcv:0005002 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that gene product by an experimental method. FBC:GM gene product detection tag FBC:GM Sequence that forms all or part of the RNA product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that RNA product by an experimental method. 2017-06-28T11:41:27Z experimental_tool_descriptor RNA detection tag FBcv:0005003 RNA detection tool FBcv:0005003 Sequence that forms all or part of the RNA product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that RNA product by an experimental method. FBC:GM RNA detection tag FBC:TJ Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that protein product by an experimental method. 2017-06-28T11:41:27Z experimental_tool_descriptor protein detection tag FBcv:0005004 protein detection tool FBcv:0005004 Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that protein product by an experimental method. FBC:GM protein detection tag FBC:TJ Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity can be used to detect the presence of that protein product. 2017-06-28T11:41:27Z MI:0365 experimental_tool_descriptor FBcv:0005005 reporter enzyme FBcv:0005005 Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity can be used to detect the presence of that protein product. FBC:GM Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that exhibits the property of fluorescence, that can be used to detect the presence of that protein product. A fluorescent protein emits light following the absorption of radiation, with the wavelength of the emitted light being longer than the excitation wavelength of the absorbed radiation. 2017-06-28T11:41:27Z MI:0687 experimental_tool_descriptor FBcv:0005006 fluorescent protein FBcv:0005006 Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that exhibits the property of fluorescence, that can be used to detect the presence of that protein product. A fluorescent protein emits light following the absorption of radiation, with the wavelength of the emitted light being longer than the excitation wavelength of the absorbed radiation. FBC:GM Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 499-519nm. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005007 green fluorescent protein FBcv:0005007 Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 499-519nm. FBC:GM http://blog.addgene.org/which-fluorescent-protein-should-i-use Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 424-467nm. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005008 blue fluorescent protein FBcv:0005008 Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 424-467nm. FBC:GM http://blog.addgene.org/which-fluorescent-protein-should-i-use Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 474-492nm. 2017-06-28T11:41:27Z MI:0733 experimental_tool_descriptor FBcv:0005009 cyan fluorescent protein FBcv:0005009 Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 474-492nm. FBC:GM http://blog.addgene.org/which-fluorescent-protein-should-i-use Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 524-538nm. 2017-06-28T11:41:27Z MI:0368 experimental_tool_descriptor FBcv:0005010 yellow fluorescent protein FBcv:0005010 Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 524-538nm. FBC:GM http://blog.addgene.org/which-fluorescent-protein-should-i-use Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 559-572nm. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005011 orange fluorescent protein FBcv:0005011 Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 559-572nm. FBC:GM http://blog.addgene.org/which-fluorescent-protein-should-i-use Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 574-610nm. 2017-06-28T11:41:27Z MI:0732 experimental_tool_descriptor FBcv:0005012 red fluorescent protein FBcv:0005012 Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 574-610nm. FBC:GM http://blog.addgene.org/which-fluorescent-protein-should-i-use Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 625-659nm. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005013 far-red fluorescent protein FBcv:0005013 Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 625-659nm. FBC:GM http://blog.addgene.org/which-fluorescent-protein-should-i-use Protein having well characterized fluorescence excitation and emission spectra, with an emission peak equal or greater than 670nm. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005014 infra-red fluorescent protein FBcv:0005014 Protein having well characterized fluorescence excitation and emission spectra, with an emission peak equal or greater than 670nm. FBC:GM http://blog.addgene.org/which-fluorescent-protein-should-i-use A fluorescent protein whose spectral properties are changeable, resulting from a reversible or irreversible change in fluorophore conformation. Changes in fluorophore conformation may occur either as a function of time (in the case of fluorescent timer proteins), or in response to an external trigger such as irradiation with a specific wavelength of light (in the case of photomodulatable fluorescent proteins). 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005015 modulatable fluorescent protein FBcv:0005015 A fluorescent protein whose spectral properties are changeable, resulting from a reversible or irreversible change in fluorophore conformation. Changes in fluorophore conformation may occur either as a function of time (in the case of fluorescent timer proteins), or in response to an external trigger such as irradiation with a specific wavelength of light (in the case of photomodulatable fluorescent proteins). FBC:TEMJ A fluorescent protein whose spectral properties can be modulated by exposure to light of a specific wavelength, triggering a conformational change of the fluorophore and subsequent change in fluorescent state. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005016 photomodulatable fluorescent protein FBcv:0005016 A fluorescent protein whose spectral properties can be modulated by exposure to light of a specific wavelength, triggering a conformational change of the fluorophore and subsequent change in fluorescent state. FBC:TEMJ PMID:20539741 A protein that can be switched from an essentially non-fluorescent state to a fluorescent state by irradiation with a pulse of light of a specific wavelength. This activation is irreversible. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005017 photoactivatable fluorescent protein FBcv:0005017 A protein that can be switched from an essentially non-fluorescent state to a fluorescent state by irradiation with a pulse of light of a specific wavelength. This activation is irreversible. FBC:GM http://www.leica-microsystems.com/science-lab/photoactivatable-photoconvertable-and-photoswitchable-fluorescent-proteins/ A protein that can be converted from one fluorescent state to another fluorescent state (with a changed emission spectrum peak) by irradiation with a pulse of light of a specific wavelength. This conversion is irreversible. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005018 photoconvertible fluorescent protein FBcv:0005018 A protein that can be converted from one fluorescent state to another fluorescent state (with a changed emission spectrum peak) by irradiation with a pulse of light of a specific wavelength. This conversion is irreversible. FBC:GM http://www.leica-microsystems.com/science-lab/photoactivatable-photoconvertable-and-photoswitchable-fluorescent-proteins/ A protein that can be reversibly switched between a non-fluorescent state and a fluorescent state, or between two different fluorescent states. The switch from one state to the other is triggered by irradiation with a pulse of light of a specific wavelength, and the switch back to the original state is triggered with a pulse of light of another specific wavelength. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005019 photoswitchable fluorescent protein FBcv:0005019 A protein that can be reversibly switched between a non-fluorescent state and a fluorescent state, or between two different fluorescent states. The switch from one state to the other is triggered by irradiation with a pulse of light of a specific wavelength, and the switch back to the original state is triggered with a pulse of light of another specific wavelength. FBC:GM FBC:TEMJ http://www.leica-microsystems.com/science-lab/photoactivatable-photoconvertable-and-photoswitchable-fluorescent-proteins/ A protein that converts from one fluorescent state to another fluorescent state (with a changed emission spectrum peak) over time. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005020 fluorescent timer protein FBcv:0005020 A protein that converts from one fluorescent state to another fluorescent state (with a changed emission spectrum peak) over time. FBC:GM Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an epitope that can be used to detect the presence of the tagged protein product. An epitope (SO:0001018) is defined as 'A binding site that, in the molecule, interacts selectively and non-covalently with antibodies, B cells or T cells.' 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005021 epitope tag FBcv:0005021 Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an epitope that can be used to detect the presence of the tagged protein product. An epitope (SO:0001018) is defined as 'A binding site that, in the molecule, interacts selectively and non-covalently with antibodies, B cells or T cells.' FBC:GM Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged gene product either to a specific subcellular location within the cell or for secretion to the extracellular space. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005022 gene product localization tag FBcv:0005022 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged gene product either to a specific subcellular location within the cell or for secretion to the extracellular space. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein either to a specific subcellular location within the cell or for secretion to the extracellular space. 2017-06-28T11:41:27Z SO:0001527 experimental_tool_descriptor FBcv:0005023 protein localization tag FBcv:0005023 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein either to a specific subcellular location within the cell or for secretion to the extracellular space. FBC:GM http://en.wikipedia.org/wiki/Target_peptide A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the nucleus. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005024 nuclear protein localization tag FBcv:0005024 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the nucleus. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the mitochondrion. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005025 mitochondrial protein localization tag FBcv:0005025 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the mitochondrion. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the peroxisome. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005026 peroxisomal protein localization tag FBcv:0005026 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the peroxisome. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the centrosome. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005027 centrosome protein localization tag FBcv:0005027 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the centrosome. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the microtubule. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005028 microtubule protein localization tag FBcv:0005028 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the microtubule. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the endoplasmic reticulum. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005029 endoplasmic reticulum protein localization tag FBcv:0005029 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the endoplasmic reticulum. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the Golgi apparatus. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005030 Golgi protein localization tag FBcv:0005030 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the Golgi apparatus. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to a cellular membrane. The membrane targeting sequence may be an intrinsic component of the membrane (GO:0031224), having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane; or may be an extrinsic component of the membrane (GO:0019898), being loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005031 membrane protein localization tag FBcv:0005031 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to a cellular membrane. The membrane targeting sequence may be an intrinsic component of the membrane (GO:0031224), having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane; or may be an extrinsic component of the membrane (GO:0019898), being loosely bound to one of its surfaces, but not integrated into the hydrophobic region. FBC:GM GOC:dos GOC:jl GOC:mah A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the plasma membrane. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005032 plasma membrane protein localization tag FBcv:0005032 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the plasma membrane. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to a vesicle. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005033 vesicle protein localization tag FBcv:0005033 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to a vesicle. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the secretory pathway. This results in the protein either being secreted or inserted into a cellular membrane, depending on the presence of other specific sequences in the tagged protein. The signal sequence must be fused to the N-terminal end of the tagged protein. 2017-06-28T11:41:27Z SO:0000418 experimental_tool_descriptor FBcv:0005034 signal sequence FBcv:0005034 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the secretory pathway. This results in the protein either being secreted or inserted into a cellular membrane, depending on the presence of other specific sequences in the tagged protein. The signal sequence must be fused to the N-terminal end of the tagged protein. FBC:GM http://en.wikipedia.org/wiki/Signal_peptide A peptide sequence used to target a tagged protein for export from the nucleus to the cytoplasm. 2017-06-28T11:41:27Z SO:0001531 NES experimental_tool_descriptor FBcv:0005035 nuclear export signal FBcv:0005035 A peptide sequence used to target a tagged protein for export from the nucleus to the cytoplasm. FBC:GM SO:0001531 http://en.wikipedia.org/wiki/Nuclear_export_signal Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific, novel property that facilitates purification of the gene product and/or any associated macromolecular complex by an experimental method. 2017-06-28T11:41:27Z isolation tag experimental_tool_descriptor FBcv:0005036 purification tag FBcv:0005036 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific, novel property that facilitates purification of the gene product and/or any associated macromolecular complex by an experimental method. FBC:GM Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which is used to regulate the activity of the tagged gene product. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005037 gene product activity regulation tag FBcv:0005037 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which is used to regulate the activity of the tagged gene product. FBC:GM Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the activity of the tagged gene product being regulated in response to a particular stimulus. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005038 conditional activity regulation tag FBcv:0005038 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the activity of the tagged gene product being regulated in response to a particular stimulus. FBC:GM Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the activity of the tagged gene product being regulated in response to irradiation with a pulse of light. 2017-06-28T11:41:27Z light-dependent activity regulation tag experimental_tool_descriptor FBcv:0005039 light-regulated activity regulation tag FBcv:0005039 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the activity of the tagged gene product being regulated in response to irradiation with a pulse of light. FBC:GM Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being regulated by binding to a small molecule, such as an ion or ligand. 2017-06-28T11:41:27Z small molecule-dependent activity regulation tag experimental_tool_descriptor FBcv:0005040 small molecule-regulated activity regulation tag FBcv:0005040 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Sequence that forms part of the protein encoded by a transgenic locus or modified endogenous locus and which allows a protein to be inactivated by the chromophore-assisted light inactivation (CALI) technique. The tag consists of a peptide sequence that specifically binds a membrane-permeable, chromophore-containing molecule. When activated using a pulse of high-intensity light that is absorbed by the chromophore but not by cellular components, the membrane-permeable molecule generates short-lived reactive oxygen species which inactivate the tagged protein to which the molecule is bound via the chromophore-assisted light inactivation tag. 2017-06-28T11:41:27Z CALI tag experimental_tool_descriptor FBcv:0005041 chromophore-assisted light inactivation tag FBcv:0005041 Sequence that forms part of the protein encoded by a transgenic locus or modified endogenous locus and which allows a protein to be inactivated by the chromophore-assisted light inactivation (CALI) technique. The tag consists of a peptide sequence that specifically binds a membrane-permeable, chromophore-containing molecule. When activated using a pulse of high-intensity light that is absorbed by the chromophore but not by cellular components, the membrane-permeable molecule generates short-lived reactive oxygen species which inactivate the tagged protein to which the molecule is bound via the chromophore-assisted light inactivation tag. FBC:GM PMID:14625562 PMID:16605242 PMID:21226520 PMID:3399501 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation. 2017-06-28T11:41:27Z gene product degradation tag experimental_tool_descriptor FBcv:0005042 degradation tag FBcv:0005042 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation. FBC:GM Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by the cell cycle. 2017-06-28T11:41:27Z cell cycle-regulated gene product degradation tag experimental_tool_descriptor FBcv:0005043 cell cycle-regulated degradation tag FBcv:0005043 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by the cell cycle. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of a biologically relevant property that is not part of or directly encoded by the genome, for example pH, redox state, membrane potential, a change in concentration of a particular molecule. For experimental tools that are used to detect a gene product directly encoded by the genome, see instead 'gene product detection tag'. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005044 genetically encoded sensor FBcv:0005044 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of a biologically relevant property that is not part of or directly encoded by the genome, for example pH, redox state, membrane potential, a change in concentration of a particular molecule. For experimental tools that are used to detect a gene product directly encoded by the genome, see instead 'gene product detection tag'. FBC:GM PMID:20664080 Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of a molecule that is not part of or directly encoded by the genome. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005045 small molecule sensor FBcv:0005045 Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of a molecule that is not part of or directly encoded by the genome. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of calcium ion concentration. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005046 calcium ion sensor FBcv:0005046 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of calcium ion concentration. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of pH. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005047 pH sensor FBcv:0005047 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of pH. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of voltage. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005048 voltage sensor FBcv:0005048 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of voltage. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the redox state of a cell/tissue. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005049 redox state sensor FBcv:0005049 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the redox state of a cell/tissue. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of changes in the mechanical force the gene product is subjected to. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005050 mechanical force sensor FBcv:0005050 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of changes in the mechanical force the gene product is subjected to. FBC:GM Component that forms part of a 'split system'. A split system component corresponds to a non-functional fragment of a functional experimental tool. When combined with another appropriate split system component in vivo, a functional experimental tool is produced. The fragments of a split system can be brought together in vivo in a number of different ways; for example, by fusing fragments to peptides that physically interact in vivo. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005051 split system component FBcv:0005051 Component that forms part of a 'split system'. A split system component corresponds to a non-functional fragment of a functional experimental tool. When combined with another appropriate split system component in vivo, a functional experimental tool is produced. The fragments of a split system can be brought together in vivo in a number of different ways; for example, by fusing fragments to peptides that physically interact in vivo. FBC:GM Non-fluorescent fragment of a fluorescent protein. A functional fluorophore can be reconstituted if a split fluorescent protein fragment is expressed with a complementary split fluorescent protein fragment and the fragments are brought together in vivo, permitting the study of biological interactions. Protein-protein interactions can be studied using the bimolecular fluorescence complementation (BiFC) technique, where a fluorescent protein is reconstituted if the two complementary split fluorescent protein fragments are fused to interacting proteins or protein domains that bring the split halves together into the same macromolecular complex. Associations between closely apposed cells can be studied if the two complementary split fluorescent protein fragments are tethered to the surface of these cells, for example to study connectivity in the nervous system using the GFP Reconstitution Across Synaptic Partners (GRASP) technique. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005052 split fluorescent protein FBcv:0005052 Non-fluorescent fragment of a fluorescent protein. A functional fluorophore can be reconstituted if a split fluorescent protein fragment is expressed with a complementary split fluorescent protein fragment and the fragments are brought together in vivo, permitting the study of biological interactions. Protein-protein interactions can be studied using the bimolecular fluorescence complementation (BiFC) technique, where a fluorescent protein is reconstituted if the two complementary split fluorescent protein fragments are fused to interacting proteins or protein domains that bring the split halves together into the same macromolecular complex. Associations between closely apposed cells can be studied if the two complementary split fluorescent protein fragments are tethered to the surface of these cells, for example to study connectivity in the nervous system using the GFP Reconstitution Across Synaptic Partners (GRASP) technique. FBC:GM PMID:11983170 PMID:18255029 Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes a catalytically inactive fragment of an enzyme whose activity can be used to detect the presence of that protein product when complementary split reporter enzyme fragments are brought together in vivo. Fragments may be brought together when fused to peptides that physically interact, permitting the study of protein-protein interactions. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005053 split reporter enzyme FBcv:0005053 Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes a catalytically inactive fragment of an enzyme whose activity can be used to detect the presence of that protein product when complementary split reporter enzyme fragments are brought together in vivo. Fragments may be brought together when fused to peptides that physically interact, permitting the study of protein-protein interactions. FBC:GM PMID:9237989 http://orcid.org/0000-0002-1373-1705 Non-functional fragment of a transcriptional activator ('driver') that includes a DNA-binding domain and which can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment that encodes a transcription activation domain, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005054 split driver - DNA-binding fragment FBcv:0005054 Non-functional fragment of a transcriptional activator ('driver') that includes a DNA-binding domain and which can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment that encodes a transcription activation domain, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments. FBC:GM Non-functional fragment of a transcriptional activator ('driver') that includes a transcription activation domain and which can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment that encodes a DNA-binding domain, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005055 split driver - transcription activation fragment FBcv:0005055 Non-functional fragment of a transcriptional activator ('driver') that includes a transcription activation domain and which can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment that encodes a DNA-binding domain, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments. FBC:GM Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which allows the tagged gene product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005056 gene product cleavage tag FBcv:0005056 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which allows the tagged gene product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process. FBC:GM Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which allows the tagged protein product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process. Examples of protein cleavage tags include sequences recognized and cleaved by proteases such as the human rhinovirus (HRV) 3C protease (often produced with the tradename PreScission Protease) and the tobacco etch virus (TEV) protease. Protein product cleavage can be used for a number of different purposes, including release of a protein after purification, or removal of a detection tag to assess that the tag does not interfere with protein function. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005057 protein cleavage tag FBcv:0005057 Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which allows the tagged protein product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process. Examples of protein cleavage tags include sequences recognized and cleaved by proteases such as the human rhinovirus (HRV) 3C protease (often produced with the tradename PreScission Protease) and the tobacco etch virus (TEV) protease. Protein product cleavage can be used for a number of different purposes, including release of a protein after purification, or removal of a detection tag to assess that the tag does not interfere with protein function. FBC:GM FBC:TEMJ Component that forms part of a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005058 binary expression system component FBcv:0005058 Component that forms part of a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. FBC:GM FlyBase:FBrf0216478 Transactivator ('driver') that is encoded by a transgenic locus or modified endogenous locus and which forms part of a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005059 binary expression system - driver FBcv:0005059 Transactivator ('driver') that is encoded by a transgenic locus or modified endogenous locus and which forms part of a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. FBC:GM FlyBase:FBrf0216478 Specific DNA sequence that is used as the effector in a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. 2017-06-28T11:41:27Z binary expression system - effector experimental_tool_descriptor FBcv:0005060 binary expression system - regulatory region FBcv:0005060 Specific DNA sequence that is used as the effector in a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. FBC:GM FlyBase:FBrf0216478 Repressor that can be used to regulate expression in a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. 2017-06-28T11:41:27Z experimental_tool_descriptor FBcv:0005061 binary expression system - repressor FBcv:0005061 Repressor that can be used to regulate expression in a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. FBC:GM FlyBase:FBrf0216478 An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site. The recognition site for a particular site-specific recombinase is defined by the enzyme itself. The recognition site contains perfect inverted repeats flanking an asymmetric spacer. Under normal conditions, the two recognition sites are identical and are reformed during the recombination event, and thus the reaction is bidirectional: recombination can occur in both 'forward' and 'reverse' directions. However, recognition sites can be mutated to drive the directionality of the reaction: different classes of site may be combined so that recombination can occur in one direction, but produces reformed sites that are no longer compatible. In addition, mutually exclusive sites have been engineered for some recombinases. Recombinases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE). 2017-06-28T11:41:27Z site-specific recombinase experimental_tool_descriptor FBcv:0005062 recombinase FBcv:0005062 An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site. The recognition site for a particular site-specific recombinase is defined by the enzyme itself. The recognition site contains perfect inverted repeats flanking an asymmetric spacer. Under normal conditions, the two recognition sites are identical and are reformed during the recombination event, and thus the reaction is bidirectional: recombination can occur in both 'forward' and 'reverse' directions. However, recognition sites can be mutated to drive the directionality of the reaction: different classes of site may be combined so that recombination can occur in one direction, but produces reformed sites that are no longer compatible. In addition, mutually exclusive sites have been engineered for some recombinases. Recombinases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE). FlyBase:FBrf0231034 The recognition site for a particular site-specific recombinase, an enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a copy of the recognition site. The recognition site contains perfect inverted repeats flanking an asymmetric spacer. Under normal conditions, the two recognition sites are identical and are reformed during the recombination event, and thus the reaction is bidirectional: recombination can occur in both 'forward' and 'reverse' directions. However, recognition sites can be mutated to drive the directionality of the reaction: different classes of site may be combined so that recombination can occur in one direction, but produces reformed sites that are no longer compatible. In addition, mutually exclusive sites have been engineered for some recombinases. Recombinases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE). 2017-06-28T11:41:27Z site-specific recombination target region experimental_tool_descriptor FBcv:0005063 recombinase target site FBcv:0005063 The recognition site for a particular site-specific recombinase, an enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a copy of the recognition site. The recognition site contains perfect inverted repeats flanking an asymmetric spacer. Under normal conditions, the two recognition sites are identical and are reformed during the recombination event, and thus the reaction is bidirectional: recombination can occur in both 'forward' and 'reverse' directions. However, recognition sites can be mutated to drive the directionality of the reaction: different classes of site may be combined so that recombination can occur in one direction, but produces reformed sites that are no longer compatible. In addition, mutually exclusive sites have been engineered for some recombinases. Recombinases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE). FlyBase:FBrf0231034 Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated in response to a particular stimulus. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a conditional driver permits further refinement of this expression pattern. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005064 binary expression system - conditional driver FBcv:0005064 Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated in response to a particular stimulus. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a conditional driver permits further refinement of this expression pattern. FBC:GM Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated by binding to a small molecule, such as an ion or ligand. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a small molecule-regulated driver permits further refinement of this expression pattern. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005065 binary expression system - small molecule-regulated driver FBcv:0005065 Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated by binding to a small molecule, such as an ion or ligand. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a small molecule-regulated driver permits further refinement of this expression pattern. FBC:GM Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated in response to a particular stimulus. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a conditional repressor permits further refinement of this expression pattern. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005066 binary expression system - conditional repressor FBcv:0005066 Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated in response to a particular stimulus. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a conditional repressor permits further refinement of this expression pattern. FBC:GM Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated by temperature. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a temperature conditional repressor permits further refinement of this expression pattern. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005067 binary expression system - temperature conditional repressor FBcv:0005067 Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated by temperature. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a temperature conditional repressor permits further refinement of this expression pattern. FBC:GM Sequence that forms all or part of a transgenic locus or modified endogenous locus and which is designed to impact or assess any proximate gene(s) when integrated into the genome. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005068 insertional mutagenesis tool FBcv:0005068 Sequence that forms all or part of a transgenic locus or modified endogenous locus and which is designed to impact or assess any proximate gene(s) when integrated into the genome. FBC:GM FBC:LC An enhancer trap cassette is designed to report or utilize the expression of endogenous enhancer elements upon integration of the cassette into the genome. The basic components of an enhancer trap cassette are a minimal promoter element fused upstream of a gene. Upon integration into the genome, a neighboring genomic enhancer may activate expression of the gene encoded by the enhancer trap cassette. Depending on the nature of this gene, the insertion may directly report the expression pattern of the 'trapped' enhancer (e.g. if the gene encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encodes a driver that forms part of a binary expression system). An enhancer trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. An enhancer trap insertion can be mutagenic, disrupting the function of an endogenous locus, depending on the particular insertion site. 2017-12-13T13:17:30Z SO:0001479 experimental_tool_descriptor enhancer detection tool FBcv:0005069 enhancer trap FBcv:0005069 An enhancer trap cassette is designed to report or utilize the expression of endogenous enhancer elements upon integration of the cassette into the genome. The basic components of an enhancer trap cassette are a minimal promoter element fused upstream of a gene. Upon integration into the genome, a neighboring genomic enhancer may activate expression of the gene encoded by the enhancer trap cassette. Depending on the nature of this gene, the insertion may directly report the expression pattern of the 'trapped' enhancer (e.g. if the gene encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encodes a driver that forms part of a binary expression system). An enhancer trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. An enhancer trap insertion can be mutagenic, disrupting the function of an endogenous locus, depending on the particular insertion site. FBC:GM FlyBase:FBrf0128252 FlyBase:FBrf0216478 PMID:10899970 enhancer detection tool FBC:GM A protein trap cassette is designed to tag protein(s) encoded by an endogenous locus upon integration of the cassette into the genome. The basic structure of a protein trap cassette is an artificial exon composed of a splice acceptor site, an open reading frame without initiation and stop codons, and a splice donor site. No promoter sequences are present. Upon integration into a coding intron of an endogenous locus, the open reading frame (ORF) encoded by the artificial exon can be incorporated into ('tag') the protein encoded by the locus. This only occurs if the insertion is in the correct orientation and when the frame of the artificial exon corresponds to that of the preceeding exon. Thus, only one out of six insertions in a coding intron will function as a protein trap. To account for each reading frame, three versions of a given protein trap element, differing only in the splice phase, are typically produced for use in an insertional mutagenesis screen. Depending on the nature of the ORF encoded by the artificial exon, the tag may be used to detect the expression pattern and/or subcellular localization of the protein (e.g. if the tag is an epitope tag or fluorescent protein), to drive expression of a gene of interest (e.g. if the tag is a driver that forms part of a binary expression system), or may modify the properties of the endogenous protein (e.g. if the tag affects protein localization or stability). A protein trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. The presence of the splice acceptor and donor sites mean that a protein trap cassette is not inherently mutagenic, since it is designed to insert in frame into a protein. However, an insertion into an intron that splits a critical functional or localization domain may alter the activity of the encoded protein, and the protein trap tag sequence itself may be designed to alter function (for example targeting the protein to a new location within the cell or altering its stability). 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005070 protein trap FBcv:0005070 A protein trap cassette is designed to tag protein(s) encoded by an endogenous locus upon integration of the cassette into the genome. The basic structure of a protein trap cassette is an artificial exon composed of a splice acceptor site, an open reading frame without initiation and stop codons, and a splice donor site. No promoter sequences are present. Upon integration into a coding intron of an endogenous locus, the open reading frame (ORF) encoded by the artificial exon can be incorporated into ('tag') the protein encoded by the locus. This only occurs if the insertion is in the correct orientation and when the frame of the artificial exon corresponds to that of the preceeding exon. Thus, only one out of six insertions in a coding intron will function as a protein trap. To account for each reading frame, three versions of a given protein trap element, differing only in the splice phase, are typically produced for use in an insertional mutagenesis screen. Depending on the nature of the ORF encoded by the artificial exon, the tag may be used to detect the expression pattern and/or subcellular localization of the protein (e.g. if the tag is an epitope tag or fluorescent protein), to drive expression of a gene of interest (e.g. if the tag is a driver that forms part of a binary expression system), or may modify the properties of the endogenous protein (e.g. if the tag affects protein localization or stability). A protein trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. The presence of the splice acceptor and donor sites mean that a protein trap cassette is not inherently mutagenic, since it is designed to insert in frame into a protein. However, an insertion into an intron that splits a critical functional or localization domain may alter the activity of the encoded protein, and the protein trap tag sequence itself may be designed to alter function (for example targeting the protein to a new location within the cell or altering its stability). FBC:GM FlyBase:FBrf0216478 FlyBase:FBrf0236840 A gene trap cassette is designed to interrupt transcription of an endogenous locus upon integration of the cassette into the genome. The basic components of a gene trap cassette are a promoterless gene with an upstream splice acceptor site. Upon integration into an intron, splicing from the genomic splice donor site to the splice acceptor site in the cassette results in a transcriptional fusion containing the endogenous exon(s) upstream of the insertion fused to the gene sequence encoded by the cassette. Any open reading frame (ORF) encoded by the trap cassette gene may be translated from this transcriptional fusion either as a translational fusion with any ORF sequence encoded by the upstream exons, or if an internal ribosome entry site (IRES) or viral 2A-like peptide sequence (which promotes ribosome skipping) is present upstream of the gene trap ORF, it may be produced as a separate protein expressed under the control of the regulatory sequences of the endogenous locus. Gene trap insertions are usually mutagenic, disrupting the locus into which they have inserted, since termination sequences are usually present at the 3' end of the cassette, truncating the endogenous transcript. Depending on the nature of the gene encoded by the gene trap cassette, a gene trap insertion may directly report the expression pattern of the disrupted locus (e.g. if it encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest in the pattern of the trapped locus (e.g. if it is a driver that forms part of a binary expression system). A gene trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. 2017-12-13T13:17:30Z SO:0001477 experimental_tool_descriptor FBcv:0005071 gene trap FBcv:0005071 A gene trap cassette is designed to interrupt transcription of an endogenous locus upon integration of the cassette into the genome. The basic components of a gene trap cassette are a promoterless gene with an upstream splice acceptor site. Upon integration into an intron, splicing from the genomic splice donor site to the splice acceptor site in the cassette results in a transcriptional fusion containing the endogenous exon(s) upstream of the insertion fused to the gene sequence encoded by the cassette. Any open reading frame (ORF) encoded by the trap cassette gene may be translated from this transcriptional fusion either as a translational fusion with any ORF sequence encoded by the upstream exons, or if an internal ribosome entry site (IRES) or viral 2A-like peptide sequence (which promotes ribosome skipping) is present upstream of the gene trap ORF, it may be produced as a separate protein expressed under the control of the regulatory sequences of the endogenous locus. Gene trap insertions are usually mutagenic, disrupting the locus into which they have inserted, since termination sequences are usually present at the 3' end of the cassette, truncating the endogenous transcript. Depending on the nature of the gene encoded by the gene trap cassette, a gene trap insertion may directly report the expression pattern of the disrupted locus (e.g. if it encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest in the pattern of the trapped locus (e.g. if it is a driver that forms part of a binary expression system). A gene trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. FBC:GM PMID:10899970 http://www.genetrap.org/tutorials/overview.html#vector The basic components of a polyA trap cassette are a promoter fused to a gene sequence that lacks a polyadenylation (polyA) sequence but is followed by a splice donor sequence. If the cassette is integrated into the genome outside a gene, the mRNA produced by the polyA trap is not polyadenylated and is expected to be rapidly degraded. However, if the cassette is integrated into an intron, the promoter in the polyA trap will drive expression of a transcriptional fusion containing the polyA gene trap fused to any downstream exons. The downstream terminal exon can provide a polyA signal, allowing stable expression of the gene encoded by the polyA trap. polyA trap cassettes can be used to report the expression of genes that are not normally expressed, or are expressed at very low levels, or may be used as a marker of successful integration of an insertion into a transcription unit. A polyA trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005072 polyA trap FBcv:0005072 The basic components of a polyA trap cassette are a promoter fused to a gene sequence that lacks a polyadenylation (polyA) sequence but is followed by a splice donor sequence. If the cassette is integrated into the genome outside a gene, the mRNA produced by the polyA trap is not polyadenylated and is expected to be rapidly degraded. However, if the cassette is integrated into an intron, the promoter in the polyA trap will drive expression of a transcriptional fusion containing the polyA gene trap fused to any downstream exons. The downstream terminal exon can provide a polyA signal, allowing stable expression of the gene encoded by the polyA trap. polyA trap cassettes can be used to report the expression of genes that are not normally expressed, or are expressed at very low levels, or may be used as a marker of successful integration of an insertion into a transcription unit. A polyA trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. FBC:GM FlyBase:FBrf0132344 FlyBase:FBrf0206814 PMID:9560157 http://www.genetrap.org/tutorials/overview.html#vector The basic component of a promoter trap cassette is a promoterless gene. This gene is not flanked by splice acceptor or donor sites, and thus the gene within a promoter trap can only be expressed if the cassette integrates into the genome within an exon, resulting in a transcriptional fusion. If the promoter trap gene encodes an open reading frame (ORF) and the insertion is in the correct frame, the trap ORF may be translated from this transcriptional fusion either as a translational fusion with ORF sequence of the disrupted endogenous locus, or if an internal ribosome entry site (IRES) or viral 2A-like peptide sequence (which promotes ribosome skipping) is present upstream of the promoter trap ORF, it may be produced as a separate protein expressed under the control of the regulatory sequences of the endogenous locus. Depending on the nature of the gene encoded by the promoter trap cassette, the insertion may directly report the expression pattern of the 'trapped' locus (e.g. if the gene encoded by the cassette is a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encoded by the cassette is a driver that form part of a binary expression system). A promoter trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. Promoter trap insertions are usually mutagenic, disrupting the locus into which they have inserted, since termination sequences are usually present at the 3' end of the cassette, truncating the endogenous transcript. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005073 promoter trap FBcv:0005073 The basic component of a promoter trap cassette is a promoterless gene. This gene is not flanked by splice acceptor or donor sites, and thus the gene within a promoter trap can only be expressed if the cassette integrates into the genome within an exon, resulting in a transcriptional fusion. If the promoter trap gene encodes an open reading frame (ORF) and the insertion is in the correct frame, the trap ORF may be translated from this transcriptional fusion either as a translational fusion with ORF sequence of the disrupted endogenous locus, or if an internal ribosome entry site (IRES) or viral 2A-like peptide sequence (which promotes ribosome skipping) is present upstream of the promoter trap ORF, it may be produced as a separate protein expressed under the control of the regulatory sequences of the endogenous locus. Depending on the nature of the gene encoded by the promoter trap cassette, the insertion may directly report the expression pattern of the 'trapped' locus (e.g. if the gene encoded by the cassette is a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encoded by the cassette is a driver that form part of a binary expression system). A promoter trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. Promoter trap insertions are usually mutagenic, disrupting the locus into which they have inserted, since termination sequences are usually present at the 3' end of the cassette, truncating the endogenous transcript. FBC:GM PMID:10899970 The basic components of a misexpression element are an enhancer sequence plus a minimal promoter. Upon integration into the genome, this element can activate expression of nearby endogenous loci. Typically, constructs containing misexpression elements are designed to insert at or near the 5' end of a gene, such that expression from the promoter within the misexpression element drives overexpression of the endogenous locus and causes a gain-of-function phenotype. However, if the insertion is within a locus, a truncated product may be produced, while an insertion in the opposite orientation to that of the direction of transcription of the endogenous locus can result in the production of an antisense transcript. If the enhancer present in the misexpression element forms part of a binary expression system, the misexpression pattern of the endogenous gene is controlled by combining the misexpression element insertion with a driver expressed in the desired temporal and spatial pattern. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005074 misexpression element FBcv:0005074 The basic components of a misexpression element are an enhancer sequence plus a minimal promoter. Upon integration into the genome, this element can activate expression of nearby endogenous loci. Typically, constructs containing misexpression elements are designed to insert at or near the 5' end of a gene, such that expression from the promoter within the misexpression element drives overexpression of the endogenous locus and causes a gain-of-function phenotype. However, if the insertion is within a locus, a truncated product may be produced, while an insertion in the opposite orientation to that of the direction of transcription of the endogenous locus can result in the production of an antisense transcript. If the enhancer present in the misexpression element forms part of a binary expression system, the misexpression pattern of the endogenous gene is controlled by combining the misexpression element insertion with a driver expressed in the desired temporal and spatial pattern. FBC:GM FlyBase:FBrf0090768 Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to an modify an organism's genetic material in a defined manner. Genome engineering can occur on many levels, ranging from targeting of an individual gene with a small modification through to the engineering of chromosomal rearrangements. In addition to the manipulation of endogenous loci, genome engineering can also be used to introduce exogenous material into the genome, and to manipulate such exogenous material already introduced the genome. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005075 genome engineering tool FBcv:0005075 Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to an modify an organism's genetic material in a defined manner. Genome engineering can occur on many levels, ranging from targeting of an individual gene with a small modification through to the engineering of chromosomal rearrangements. In addition to the manipulation of endogenous loci, genome engineering can also be used to introduce exogenous material into the genome, and to manipulate such exogenous material already introduced the genome. FlyBase:FBrf0231034 An enzyme that mediates an exchange reaction between two DNA templates, resulting in integration of DNA from one of the templates into the other. An integrase binds a pair of compatible recognition sites (typically called attP and attB) which each contain a short integration core flanked by imperfect inverted repeats that are not identical. Exchange between the attP/attB pair results in the formation of hybrid sites (typically called attL and attR) that are no longer a substrate of the integrase. Thus the exchange reaction driven by an integrase is unidirectional. Mutually exclusive pairs of recognition site have been engineered for some integrases. Integrases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE). 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005076 integrase FBcv:0005076 An enzyme that mediates an exchange reaction between two DNA templates, resulting in integration of DNA from one of the templates into the other. An integrase binds a pair of compatible recognition sites (typically called attP and attB) which each contain a short integration core flanked by imperfect inverted repeats that are not identical. Exchange between the attP/attB pair results in the formation of hybrid sites (typically called attL and attR) that are no longer a substrate of the integrase. Thus the exchange reaction driven by an integrase is unidirectional. Mutually exclusive pairs of recognition site have been engineered for some integrases. Integrases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE). FlyBase:FBrf0231034 An enzyme that catalyzes hydrolysis of DNA in a site-specific manner. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome. 2017-12-13T13:17:30Z experimental_tool_descriptor site-specific DNA nuclease FBcv:0005077 nuclease FBcv:0005077 An enzyme that catalyzes hydrolysis of DNA in a site-specific manner. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome. FBC:GM FlyBase:FBrf0231034 site-specific DNA nuclease FBC:GM An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, and in which the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest, rather than being an inherent property of the nuclease itself. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005078 RNA-guided nuclease FBcv:0005078 An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, and in which the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest, rather than being an inherent property of the nuclease itself. FBC:GM FlyBase:FBrf0231034 A recognition site for an integrase, an enzyme that mediates an exchange reaction between two DNA templates, resulting in integration of DNA from one of the templates into the other. An integrase binds a pair of compatible recognition sites (typically called attP and attB) which each contain a short integration core flanked by imperfect inverted repeats that are not identical. Exchange between the attP/attB pair results in the formation of hybrid sites (typically called attL and attR) that are no longer a substrate of the integrase. Thus the exchange reaction driven by an integrase is unidirectional. Mutually exclusive pairs of recognition site have been engineered for some integrases. Integrases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE). 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005079 integrase target site FBcv:0005079 A recognition site for an integrase, an enzyme that mediates an exchange reaction between two DNA templates, resulting in integration of DNA from one of the templates into the other. An integrase binds a pair of compatible recognition sites (typically called attP and attB) which each contain a short integration core flanked by imperfect inverted repeats that are not identical. Exchange between the attP/attB pair results in the formation of hybrid sites (typically called attL and attR) that are no longer a substrate of the integrase. Thus the exchange reaction driven by an integrase is unidirectional. Mutually exclusive pairs of recognition site have been engineered for some integrases. Integrases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE). FlyBase:FBrf0231034 A recognition site for a site-specific DNA nuclease, an enzyme that catalyzes hydrolysis of DNA in a site-specific manner. The DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005080 nuclease target site FBcv:0005080 A recognition site for a site-specific DNA nuclease, an enzyme that catalyzes hydrolysis of DNA in a site-specific manner. The DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome. FBC:GM FlyBase:FBrf0231034 Engineered sequence that forms all or part of a transgenic locus or modified endogenous locus and that has the property of a 'regulatory_region' (SO:0005836). 'regulatory_region' is defined as 'A region of sequence that is involved in the control of a biological process. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005081 engineered regulatory region FBcv:0005081 Engineered sequence that forms all or part of a transgenic locus or modified endogenous locus and that has the property of a 'regulatory_region' (SO:0005836). 'regulatory_region' is defined as 'A region of sequence that is involved in the control of a biological process. FBC:GM Engineered sequence that forms all or part of a transgenic locus or modified endogenous locus and that has the property of a 'transcription_regulatory_region' (SO:0001679). 'transcription_regulatory_region' is defined as 'A regulatory region that is involved in the control of the process of transcription.'. 2017-12-13T13:17:30Z experimental_tool_descriptor FBcv:0005082 engineered transcription regulatory region FBcv:0005082 Engineered sequence that forms all or part of a transgenic locus or modified endogenous locus and that has the property of a 'transcription_regulatory_region' (SO:0001679). 'transcription_regulatory_region' is defined as 'A regulatory region that is involved in the control of the process of transcription.'. FBC:GM Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by a small molecule. 2017-12-22T13:09:10Z small molecule-dependent gene product degradation tag small molecule-regulated gene product degradation tag experimental_tool_descriptor FBcv:0005083 small molecule-regulated degradation tag FBcv:0005083 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by a small molecule. FBC:GM Phenotype that is any abnormality in copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.' copulation defective phenotypic_class FBcv:0006000 abnormal copulation FBcv:0006000 Phenotype that is any abnormality in copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.' FBC:TEMJ ISBN:0721662544 Phenotype that is an increase in the number of gametes produced. phenotypic_class FBcv:0006001 increased fecundity FBcv:0006001 Phenotype that is an increase in the number of gametes produced. FBC:TEMJ Phenotype that is a decrease in the number of gametes produced. reduced fecundity phenotypic_class FBcv:0006002 decreased fecundity FBcv:0006002 Phenotype that is a decrease in the number of gametes produced. FBC:TEMJ FlyBase miscellaneous CV FBcv:0006003 population of Drosophila FBcv:0006003 Phenotype that is any abnormality in oviposition (GO:0018991) despite production of eggs. 'oviposition' is defined as: 'A reproductive behavior that results in the deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.'. oviposition defective phenotypic_class FBcv:0006004 This term should only be used to report defects specifically in oviposition, as opposed to an overall loss of fertility. It is not possible to observe an oviposition abnormality if eggs are not being produced. If a difference in "oviposition rate" is measured by authors as a proxy for sterility/fertility, it would be better to use the terms "sterile", "semi-sterile", or "semi-fertile", as appropriate. abnormal oviposition FBcv:0006004 Phenotype that is any abnormality in oviposition (GO:0018991) despite production of eggs. 'oviposition' is defined as: 'A reproductive behavior that results in the deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.'. FBC:TEMJ GOC:ems PMID:18050396 PMID:31164023 A phenotype that is an increased occurrence of cell division (GO:0051301). 'cell division' is defined as 'The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.'. phenotypic_class FBcv:0006005 increased occurrence of cell division FBcv:0006005 A phenotype that is an increased occurrence of cell division (GO:0051301). 'cell division' is defined as 'The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.'. FBC:TEMJ GOC:di GOC:go_curators GOC:pr A phenotype that is a decreased occurrence of cell division (GO:0051301). 'cell division' is defined as 'The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.'. reduced occurrence of cell division phenotypic_class FBcv:0006006 decreased occurrence of cell division FBcv:0006006 A phenotype that is a decreased occurrence of cell division (GO:0051301). 'cell division' is defined as 'The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.'. FBC:TEMJ GOC:di GOC:go_curators GOC:pr FlyBase miscellaneous CV FBcv:0006007 population of cells FBcv:0006007 A short report describing a single stand-alone research finding that is peer-reviewed and published. 2019-06-25T08:45:04Z pub_type FBcv:0007000 Obsoleted, as 'paper' publication type will now be used for micropublications. obsolete micropublication true FBcv:0007000 A short report describing a single stand-alone research finding that is peer-reviewed and published. FBC:SM http://www.micropublication.org A version of a scientific manuscript that is shared publicly on the web without peer review. In most cases, work posted as a preprint will be submitted for peer review at a journal. 2019-06-25T09:00:50Z pub_type FBcv:0007001 preprint FBcv:0007001 A version of a scientific manuscript that is shared publicly on the web without peer review. In most cases, work posted as a preprint will be submitted for peer review at a journal. FBC:SM http://www.asapbio.org/preprint-info Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to regulate the activity of a neuron. This is often achieved by manipulation of membrane potential or synaptic transmission dynamics. 2019-06-25T09:54:56Z electrically signalling cell activity regulation tool experimental_tool_descriptor FBcv:0007002 neuron activity regulation tool FBcv:0007002 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to regulate the activity of a neuron. This is often achieved by manipulation of membrane potential or synaptic transmission dynamics. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron. This is often achieved by inducing membrane hyperpolarization (GO:0060081). 2019-06-25T10:13:24Z electrically signalling cell inhibition tool experimental_tool_descriptor FBcv:0007003 neuron inhibition tool FBcv:0007003 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron. This is often achieved by inducing membrane hyperpolarization (GO:0060081). FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated in response to a particular stimulus. 2019-06-25T10:15:49Z experimental_tool_descriptor FBcv:0007004 conditional neuron inhibition tool FBcv:0007004 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated in response to a particular stimulus. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by irradiation with a pulse of light. 2019-06-25T10:17:16Z optogenetic neuron inhibition tool experimental_tool_descriptor FBcv:0007005 light-regulated neuron inhibition tool FBcv:0007005 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by irradiation with a pulse of light. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by binding to a small molecule, such as an ion or ligand. 2019-06-25T10:18:34Z experimental_tool_descriptor FBcv:0007006 small molecule-regulated neuron inhibition tool FBcv:0007006 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by temperature. 2019-06-25T10:20:00Z thermogenetic neuron inhibition tool experimental_tool_descriptor FBcv:0007007 temperature-regulated neuron inhibition tool FBcv:0007007 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by temperature. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron. This is often achieved by inducing membrane depolarization (GO:0051899). 2019-06-25T10:25:57Z electrically signalling cell activation tool experimental_tool_descriptor FBcv:0007008 neuron activation tool FBcv:0007008 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron. This is often achieved by inducing membrane depolarization (GO:0051899). FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated in response to a particular stimulus. 2019-06-25T10:26:57Z experimental_tool_descriptor FBcv:0007009 conditional neuron activation tool FBcv:0007009 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated in response to a particular stimulus. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by temperature. 2019-06-25T10:28:57Z thermogenetic neuron activation tool experimental_tool_descriptor FBcv:0007010 temperature-regulated neuron activation tool FBcv:0007010 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by temperature. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by irradiation with a pulse of light. 2019-06-25T10:31:02Z optogenetic neuron activation tool experimental_tool_descriptor FBcv:0007011 light-regulated neuron activation tool FBcv:0007011 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by irradiation with a pulse of light. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by binding to a small molecule, such as an ion or ligand. 2019-06-25T10:34:48Z experimental_tool_descriptor FBcv:0007012 small molecule-regulated neuron activation tool FBcv:0007012 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure. 2019-06-25T10:53:21Z experimental_tool_descriptor FBcv:0007013 cell ablation tool FBcv:0007013 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated in response to a particular stimulus. 2019-06-25T10:54:32Z experimental_tool_descriptor FBcv:0007014 conditional cell ablation tool FBcv:0007014 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated in response to a particular stimulus. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by temperature. 2019-06-25T10:55:40Z experimental_tool_descriptor FBcv:0007015 temperature-regulated cell ablation tool FBcv:0007015 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by temperature. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by irradiation with a pulse of light. 2019-06-25T10:56:47Z experimental_tool_descriptor FBcv:0007016 light-regulated cell ablation tool FBcv:0007016 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by irradiation with a pulse of light. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by binding to a small molecule, such as an ion or ligand. 2019-06-25T10:57:45Z experimental_tool_descriptor FBcv:0007017 small molecule-regulated cell ablation tool FBcv:0007017 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activity of a specific biological process. 2019-06-25T11:38:48Z reporter of biological process pathway activity experimental_tool_descriptor FBcv:0007018 biological process activity sensor FBcv:0007018 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activity of a specific biological process. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activity of a specific signal transduction pathway. 2019-06-25T11:41:19Z reporter of signal transduction pathway activity experimental_tool_descriptor FBcv:0007019 signal transduction pathway activity sensor FBcv:0007019 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activity of a specific signal transduction pathway. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activation state of a specific gene product. 2019-06-25T11:43:24Z gene product activation state detection tool experimental_tool_descriptor FBcv:0007020 gene product activity sensor FBcv:0007020 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activation state of a specific gene product. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring macromolecules, facilitating the subsequent purification or detection of the tagged macromolecules by an experimental method. 2019-06-25T14:01:14Z experimental_tool_descriptor FBcv:0007021 proximity labeling tool FBcv:0007021 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring macromolecules, facilitating the subsequent purification or detection of the tagged macromolecules by an experimental method. FBC:GM PMID:30774936 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring proteins, facilitating the subsequent purification or detection of the tagged proteins by an experimental method. 2019-06-25T14:08:26Z experimental_tool_descriptor FBcv:0007022 proximity labeling tool (protein) FBcv:0007022 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring proteins, facilitating the subsequent purification or detection of the tagged proteins by an experimental method. FBC:GM PMID:29125959 PMID:30774936 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring RNA, facilitating the subsequent purification or detection of the tagged RNA by an experimental method. 2019-06-25T14:18:36Z experimental_tool_descriptor FBcv:0007023 proximity labeling tool (RNA) FBcv:0007023 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring RNA, facilitating the subsequent purification or detection of the tagged RNA by an experimental method. FBC:GM PMID:30774936 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring DNA, facilitating the subsequent purification or detection of the tagged DNA by an experimental method. 2019-06-25T14:24:50Z experimental_tool_descriptor FBcv:0007024 proximity labeling tool (DNA) FBcv:0007024 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring DNA, facilitating the subsequent purification or detection of the tagged DNA by an experimental method. FBC:GM PMID:30774936 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to facilitate the detection of a specific cell population by an experimental method. 2019-06-25T14:41:38Z experimental_tool_descriptor FBcv:0007025 cell labeling tool FBcv:0007025 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to facilitate the detection of a specific cell population by an experimental method. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific property that can be used to stochastically label cells in the same sample with different colors of fluorescent protein. This property can be exploited to study cell morphology and to track lineages of clonally related cells. 2019-06-25T14:42:41Z experimental_tool_descriptor FBcv:0007026 multicolor cell labeling tool FBcv:0007026 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific property that can be used to stochastically label cells in the same sample with different colors of fluorescent protein. This property can be exploited to study cell morphology and to track lineages of clonally related cells. FBC:GM PMID:25491327 Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which allows the tagged protein product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process that can be regulated by binding to a small molecule, such as an ion or ligand. 2019-06-25T14:58:18Z experimental_tool_descriptor FBcv:0007027 small molecule-regulated protein cleavage tag FBcv:0007027 Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which allows the tagged protein product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process that can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Catalytically inactive fragment of a recombinase. A functional recombinase can be reconstituted when complementary split recombinase fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2019-06-26T07:55:34Z experimental_tool_descriptor FBcv:0007028 split recombinase FBcv:0007028 Catalytically inactive fragment of a recombinase. A functional recombinase can be reconstituted when complementary split recombinase fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Sequence that has a property that allows specific binding to another macromolecule. 2019-06-26T08:11:17Z experimental_tool_descriptor FBcv:0007029 specific binding tool FBcv:0007029 Sequence that has a property that allows specific binding to another macromolecule. FBC:GM Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated in response to a particular stimulus. 2019-06-26T08:12:05Z experimental_tool_descriptor FBcv:0007030 conditional specific binding tool FBcv:0007030 Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated in response to a particular stimulus. FBC:GM Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by irradiation with a pulse of light. 2019-06-26T08:13:06Z experimental_tool_descriptor FBcv:0007031 light-regulated specific binding tool FBcv:0007031 Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by irradiation with a pulse of light. FBC:GM Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by temperature. 2019-06-26T08:13:56Z experimental_tool_descriptor FBcv:0007032 temperature-regulated specific binding tool FBcv:0007032 Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by temperature. FBC:GM Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by binding to a small molecule, such as an ion or ligand. 2019-06-26T08:14:35Z experimental_tool_descriptor FBcv:0007033 small molecule-regulated specific binding tool FBcv:0007033 Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Genes whose products act in a specified signal transduction pathway. 2024-03-15T11:24:40Z group_descriptor FBcv:0007034 signaling pathway group FBcv:0007034 Genes whose products act in a specified signal transduction pathway. FBC:SM An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, having a cognate recognition site of 20-30bp. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome. 2019-06-26T09:17:20Z experimental_tool_descriptor FBcv:0007035 meganuclease FBcv:0007035 An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, having a cognate recognition site of 20-30bp. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome. FBC:GM FlyBase:FBrf0231034 Work consisting of speeches read or delivered before an audience or class, especially for instruction or to set forth some subject. 2020-01-23T15:24:54Z pub_type FBcv:0007036 lecture FBcv:0007036 Work consisting of speeches read or delivered before an audience or class, especially for instruction or to set forth some subject. MeSH:D019531 An immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact with the antigen that induced its synthesis and with molecules containing structures similar to that antigen. An antigen is any substance capable of inducing a specific immune response, including but not limited to toxins, bacterial proteins and viruses. 2020-01-24T08:44:55Z XCO:0000194 experimental_tool_descriptor FBcv:0007037 antibody FBcv:0007037 An immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact with the antigen that induced its synthesis and with molecules containing structures similar to that antigen. An antigen is any substance capable of inducing a specific immune response, including but not limited to toxins, bacterial proteins and viruses. XCO:0000194 Phenotype expressed only in the presence or absence of light, which may be white light or particular wavelength(s). 2020-01-24T09:10:41Z environmental_qualifier FBcv:0007038 light conditional FBcv:0007038 Phenotype expressed only in the presence or absence of light, which may be white light or particular wavelength(s). FBC:CP An antibody whose domain architecture has been engineered in vitro. An engineered antibody typically contains only a subset of the domains found in a naturally occurring antibody. In some cases, domains that are normally found in different chains of a naturally occurring antibody are synthesized as a single fusion protein. 2020-02-03T11:36:12Z experimental_tool_descriptor FBcv:0007039 engineered antibody FBcv:0007039 An antibody whose domain architecture has been engineered in vitro. An engineered antibody typically contains only a subset of the domains found in a naturally occurring antibody. In some cases, domains that are normally found in different chains of a naturally occurring antibody are synthesized as a single fusion protein. FBC:GM An engineered antibody consisting of the antigen-binding variable domain (VHH domain) of a camelid single-domain heavy chain antibody (HCab). 2020-02-03T11:51:11Z experimental_tool_descriptor FBcv:0007040 nanobody FBcv:0007040 An engineered antibody consisting of the antigen-binding variable domain (VHH domain) of a camelid single-domain heavy chain antibody (HCab). FBC:GM PMID:22886243 PMID:8502296 PMID:9323027 An engineered antibody consisting of the heavy (VH) and light (VL) chains of an immunoglobulin, separated by a short flexible linker peptide and expressed as a single fusion protein. 2020-02-03T12:25:24Z sFv antibody scFv antibody single-chain variable region fragment antibody experimental_tool_descriptor FBcv:0007041 single-chain variable fragment antibody FBcv:0007041 An engineered antibody consisting of the heavy (VH) and light (VL) chains of an immunoglobulin, separated by a short flexible linker peptide and expressed as a single fusion protein. FBC:GM PMID:3045807 sFv antibody PMID:3045807 scFv antibody FBC:GM single-chain variable region fragment antibody PMID:3045807 An RMCE target element contains a region of DNA sequence flanked by a pair of target sites for a recombinase or an integrase, which are arranged such that this target sequence cassette can be replaced with donor sequence from a compatible RMCE donor element via recombination-mediated cassette exchange (RMCE). For RMCE mediated by a recombinase, the target cassette is flanked by two non-identical recombinase target sites that each carry a different mutation in the spacer sequence of the target site; this renders the two sites incompatible with each other. A compatible RMCE donor cassette is flanked by the same pair of non-identical sites; in the presence of recombinase, a double recombination event between the identical sites on the donor and target sequences results in replacement of the target cassette with the donor cassette. In the case of RMCE mediated by an integrase, the RMCE cassette is flanked by identical integrase target sites, while a compatible RMCE donor cassette is flanked by copies of the orthogonal integrase target site; in the presence of integrase, a double recombination event results in the target cassette being replaced with that of the donor cassette. In this case, if the flanking sites are in inverted orientation, replacement of the target cassette can occur in either direction. 2020-02-03T14:52:50Z recombination-mediated cassette exchange target element experimental_tool_descriptor FBcv:0007042 RMCE target element FBcv:0007042 An RMCE target element contains a region of DNA sequence flanked by a pair of target sites for a recombinase or an integrase, which are arranged such that this target sequence cassette can be replaced with donor sequence from a compatible RMCE donor element via recombination-mediated cassette exchange (RMCE). For RMCE mediated by a recombinase, the target cassette is flanked by two non-identical recombinase target sites that each carry a different mutation in the spacer sequence of the target site; this renders the two sites incompatible with each other. A compatible RMCE donor cassette is flanked by the same pair of non-identical sites; in the presence of recombinase, a double recombination event between the identical sites on the donor and target sequences results in replacement of the target cassette with the donor cassette. In the case of RMCE mediated by an integrase, the RMCE cassette is flanked by identical integrase target sites, while a compatible RMCE donor cassette is flanked by copies of the orthogonal integrase target site; in the presence of integrase, a double recombination event results in the target cassette being replaced with that of the donor cassette. In this case, if the flanking sites are in inverted orientation, replacement of the target cassette can occur in either direction. FBC:GM FlyBase:FBrf0231034 PMID:21445009 PMID:7947678 An RMCE donor element contains a region of DNA sequence flanked by a pair of target sites for a recombinase or an integrase, which are arranged such that this donor sequence cassette can be used to replace target sequence of a compatible RMCE target element via recombination-mediated cassette exchange (RMCE). For RMCE mediated by a recombinase, the target cassette is flanked by two non-identical recombinase target sites that each carry a different mutation in the spacer sequence of the target site; this renders the two sites incompatible with each other. A compatible RMCE donor cassette is flanked by the same pair of non-identical sites; in the presence of recombinase, a double recombination event between the identical sites on the donor and target sequences results in replacement of the target cassette with the donor cassette. In the case of RMCE mediated by an integrase, the RMCE cassette is flanked by identical integrase target sites, while a compatible RMCE donor cassette is flanked by copies of the orthogonal integrase target site; in the presence of integrase, a double recombination event results in the target cassette being replaced with that of the donor cassette. In this case, if the flanking sites are in inverted orientation, replacement of the target cassette can occur in either direction. 2020-02-03T15:00:41Z recombination-mediated cassette exchange donor element experimental_tool_descriptor FBcv:0007043 RMCE donor element FBcv:0007043 An RMCE donor element contains a region of DNA sequence flanked by a pair of target sites for a recombinase or an integrase, which are arranged such that this donor sequence cassette can be used to replace target sequence of a compatible RMCE target element via recombination-mediated cassette exchange (RMCE). For RMCE mediated by a recombinase, the target cassette is flanked by two non-identical recombinase target sites that each carry a different mutation in the spacer sequence of the target site; this renders the two sites incompatible with each other. A compatible RMCE donor cassette is flanked by the same pair of non-identical sites; in the presence of recombinase, a double recombination event between the identical sites on the donor and target sequences results in replacement of the target cassette with the donor cassette. In the case of RMCE mediated by an integrase, the RMCE cassette is flanked by identical integrase target sites, while a compatible RMCE donor cassette is flanked by copies of the orthogonal integrase target site; in the presence of integrase, a double recombination event results in the target cassette being replaced with that of the donor cassette. In this case, if the flanking sites are in inverted orientation, replacement of the target cassette can occur in either direction. FBC:GM FlyBase:FBrf0231034 PMID:21445009 PMID:7947678 A docking element is an element that has been introduced into a site in the genome to allow integration of DNA at a defined location; this neutralizes the problem of position effects that are seen with non-specific insertion techniques such as transposable-element-mediated transgenesis. A docking element contains a single target site for an integrase, allowing subsequent integration of DNA into this site from a donor element via integrase mediated recombination. The docking element in the genome typically contains the 'attB' site and the donor plasmid contains the 'attP' site, since this directionality gives higher integration rates compared to the alternative combination where the 'attB' site is integrated into the genome. A docking element insertion is typically selected to be 'benign' (that is it does not result in disruption of an endogenous locus) and to show a high rate of integration in the presence of integrase. 2020-02-03T15:54:09Z docking site element landing site element experimental_tool_descriptor FBcv:0007044 This includes any element containing a single site for integrase-mediated integration, as in FBrf0231034 Fig 10a, but not elements with multiple integrase sites, as in FBrf0231034 Fig 10b (see FBcv:0007042 - RMCE target element). Elements with sites for recombinase-mediated exchange (as in FBrf0231034 Fig 10c) are only included if they additionally carry exactly one integrase site for integrase-mediated integration. docking element FBcv:0007044 A docking element is an element that has been introduced into a site in the genome to allow integration of DNA at a defined location; this neutralizes the problem of position effects that are seen with non-specific insertion techniques such as transposable-element-mediated transgenesis. A docking element contains a single target site for an integrase, allowing subsequent integration of DNA into this site from a donor element via integrase mediated recombination. The docking element in the genome typically contains the 'attB' site and the donor plasmid contains the 'attP' site, since this directionality gives higher integration rates compared to the alternative combination where the 'attB' site is integrated into the genome. A docking element insertion is typically selected to be 'benign' (that is it does not result in disruption of an endogenous locus) and to show a high rate of integration in the presence of integrase. FBC:GM FlyBase:FBrf0192974 FlyBase:FBrf0194996 FlyBase:FBrf0231034 PMID:11359900 PMID:12563279 Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to modify an RNA of interest in a defined manner. Examples of RNA engineering include the targeting of an individual transcript for knockdown, and targeted manipulation of RNA splicing or editing. 2020-02-04T09:01:14Z experimental_tool_descriptor FBcv:0007045 RNA engineering tool FBcv:0007045 Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to modify an RNA of interest in a defined manner. Examples of RNA engineering include the targeting of an individual transcript for knockdown, and targeted manipulation of RNA splicing or editing. FBC:GM PMID:30021724 PMID:30388409 PMID:31367845 An enzyme that catalyzes hydrolysis of RNA in a site-specific manner, and in which the specificity is determined by a guide RNA that contains sequence complementary to the target RNA sequence of interest, rather than being an inherent property of the ribonuclease itself. This property can be used to modify an organism's transcriptome in a defined manner. 2020-02-04T09:12:14Z experimental_tool_descriptor FBcv:0007046 RNA-guided ribonuclease FBcv:0007046 An enzyme that catalyzes hydrolysis of RNA in a site-specific manner, and in which the specificity is determined by a guide RNA that contains sequence complementary to the target RNA sequence of interest, rather than being an inherent property of the ribonuclease itself. This property can be used to modify an organism's transcriptome in a defined manner. FBC:GM PMID:30021724 PMID:30388409 PMID:31367845 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by irradiation with a pulse of light. 2020-12-10T13:05:28Z light-regulated gene product degradation tag experimental_tool_descriptor FBcv:0007047 light-regulated degradation tag FBcv:0007047 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by irradiation with a pulse of light. FBC:GM Present in the correct location but in smaller numbers than in wild-type. 2020-12-14T14:38:52Z structural_qualifier FBcv:0007048 decreased number FBcv:0007048 Present in the correct location but in smaller numbers than in wild-type. FBC:CP Anatomical structure that would be present in wild-type is not present. 2020-12-14T14:39:35Z PATO:0000462 structural_qualifier FBcv:0007049 absent FBcv:0007049 Anatomical structure that would be present in wild-type is not present. FBC:CP A clone of somatic cells that share a genotype that is different from the genotype of the animal and are intentionally generated in a specific tissue of the organism. 2021-08-26T09:58:12Z clone_qualifier FBcv:0007050 somatic clone - tissue specific FBcv:0007050 A clone of somatic cells that share a genotype that is different from the genotype of the animal and are intentionally generated in a specific tissue of the organism. FBC:AO A clone of somatic cells that share a mutant genotype that includes being Minute +/+ and that are part of and derived from an animal with a different genotype that includes being Minute +/- and are intentionally generated in a specific tissue of the organism. 2021-08-26T10:04:31Z clone_qualifier FBcv:0007051 somatic clone - tissue specific, Minute background FBcv:0007051 A clone of somatic cells that share a mutant genotype that includes being Minute +/+ and that are part of and derived from an animal with a different genotype that includes being Minute +/- and are intentionally generated in a specific tissue of the organism. FBC:CP A peptide sequence used to target a tagged protein for export from the nucleus to the cytoplasm, where this property can be regulated by irradiation with a pulse of light. 2022-04-26T11:49:16Z experimental_tool_descriptor FBcv:0007052 light-regulated nuclear export signal FBcv:0007052 A peptide sequence used to target a tagged protein for export from the nucleus to the cytoplasm, where this property can be regulated by irradiation with a pulse of light. FBC:GM FlyBase:FBrf0253050 PMID:26853913 Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by a particular stimulus. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate stimulus is applied. 2022-05-04T14:32:02Z FlyBase miscellaneous CV FBcv:0007053 Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation. obsolete conditional split driver - transcription activation fragment true FBcv:0007053 Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by a particular stimulus. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate stimulus is applied. FBC:GM Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by irradiation with a pulse of light. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate light stimulus is applied. 2022-05-04T14:33:41Z FlyBase miscellaneous CV FBcv:0007054 Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation. obsolete light-regulated split driver - transcription activation fragment true FBcv:0007054 Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by irradiation with a pulse of light. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate light stimulus is applied. FBC:GM Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by binding to a small molecule, such as an ion or ligand. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate small molecule stimulus is applied. 2022-05-04T14:34:38Z FlyBase miscellaneous CV FBcv:0007055 Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation. obsolete small molecule-regulated split driver - transcription activation fragment true FBcv:0007055 Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by binding to a small molecule, such as an ion or ligand. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate small molecule stimulus is applied. FBC:GM Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by a particular stimulus. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate stimulus is applied. 2022-05-04T14:35:30Z FlyBase miscellaneous CV FBcv:0007056 Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation. obsolete conditional split driver - DNA-binding fragment true FBcv:0007056 Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by a particular stimulus. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate stimulus is applied. FBC:GM Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by irradiation with a pulse of light. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate light stimulus is applied. 2022-05-04T14:37:56Z FlyBase miscellaneous CV FBcv:0007057 Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation. obsolete light-regulated split driver - DNA-binding fragment true FBcv:0007057 Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by irradiation with a pulse of light. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate light stimulus is applied. FBC:GM Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by binding to a small molecule, such as an ion or ligand. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate small molecule stimulus is applied. 2022-05-04T14:38:38Z FlyBase miscellaneous CV FBcv:0007058 Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation. obsolete small molecule-regulated split driver - DNA-binding fragment true FBcv:0007058 Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by binding to a small molecule, such as an ion or ligand. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate small molecule stimulus is applied. FBC:GM An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site (defined by the enzyme itself), where the activity of the enzyme can be regulated in response to a particular stimulus. 2022-05-04T14:52:00Z experimental_tool_descriptor FBcv:0007059 conditional recombinase FBcv:0007059 An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site (defined by the enzyme itself), where the activity of the enzyme can be regulated in response to a particular stimulus. FBC:GM An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site (defined by the enzyme itself), where the activity of the enzyme can be regulated by binding to a small molecule, such as an ion or ligand. 2022-05-04T14:53:20Z experimental_tool_descriptor FBcv:0007060 small molecule-regulated recombinase FBcv:0007060 An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site (defined by the enzyme itself), where the activity of the enzyme can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Catalytically inactive fragment of a recombinase that can be used to reconstitute a functional recombinase when brought together in vivo with a complementary split recombinase fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus. 2022-05-04T14:56:23Z experimental_tool_descriptor FBcv:0007061 conditional split recombinase FBcv:0007061 Catalytically inactive fragment of a recombinase that can be used to reconstitute a functional recombinase when brought together in vivo with a complementary split recombinase fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus. FBC:GM Catalytically inactive fragment of a recombinase that can be used to reconstitute a functional recombinase when brought together in vivo with a complementary split recombinase fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light. 2022-05-04T14:57:37Z experimental_tool_descriptor FBcv:0007062 light-regulated split recombinase FBcv:0007062 Catalytically inactive fragment of a recombinase that can be used to reconstitute a functional recombinase when brought together in vivo with a complementary split recombinase fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light. FBC:GM A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the nucleus, where this property can be regulated by irradiation with a pulse of light. 2022-08-19T13:19:05Z experimental_tool_descriptor FBcv:0007063 light-regulated nuclear protein localization tag FBcv:0007063 A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the nucleus, where this property can be regulated by irradiation with a pulse of light. FBC:GM Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated by irradiation with a pulse of light. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a light-regulated driver permits further refinement of this expression pattern. 2023-01-18T11:52:12Z experimental_tool_descriptor FBcv:0007064 binary expression system - light-regulated driver FBcv:0007064 Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated by irradiation with a pulse of light. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a light-regulated driver permits further refinement of this expression pattern. FBC:GM Genes whose products act in a specified metabolic pathway. 2024-03-15T11:25:37Z group_descriptor FBcv:0007065 metabolic pathway group FBcv:0007065 Genes whose products act in a specified metabolic pathway. FBC:SM Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity results in covalent tagging of the protein product with a small molecule whose properties (typically fluorescence) can be used to detect the presence of that protein product. 2024-04-12T10:15:59Z experimental_tool_descriptor FBcv:0007066 chemical labeling reporter FBcv:0007066 Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity results in covalent tagging of the protein product with a small molecule whose properties (typically fluorescence) can be used to detect the presence of that protein product. FBC:GM Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity results in bioluminescence, which can be used to detect the presence of that protein product. 2024-04-12T10:18:38Z experimental_tool_descriptor FBcv:0007067 bioluminescence reporter FBcv:0007067 Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity results in bioluminescence, which can be used to detect the presence of that protein product. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and which can be used to target a gene product for degradation in a defined manner. 2024-04-16T15:24:59Z experimental_tool_descriptor FBcv:0007068 Degradation tool may or may not be fused directly to the degradation target. gene product degradation tool FBcv:0007068 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and which can be used to target a gene product for degradation in a defined manner. FBC:GM Phenotype that is any abnormality in anesthesia-resistant memory (GO:0007615). 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.' 2020-12-15T14:46:41Z phenotypic_class FBcv:0007500 abnormal anesthesia-resistant memory FBcv:0007500 Phenotype that is any abnormality in anesthesia-resistant memory (GO:0007615). 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.' PMID:15143285 PMID:17088531 Phenotype that is any abnormality in short-term memory (GO:0007614). 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.' 2020-12-15T14:50:19Z phenotypic_class FBcv:0007501 abnormal short-term memory FBcv:0007501 Phenotype that is any abnormality in short-term memory (GO:0007614). 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.' ISBN:0582227089 http://hebb.mit.edu/courses/9.03/lecture4.html Phenotype that is any abnormality in medium-term memory (GO:0072375). 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).' 2020-12-15T14:51:08Z phenotypic_class FBcv:0007502 abnormal medium-term memory FBcv:0007502 Phenotype that is any abnormality in medium-term memory (GO:0072375). 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).' GOC:sart PMID:14659098 PMID:7923375 Phenotype that is any abnormality in long-term memory (GO:0007616). 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.' 2020-12-15T14:51:45Z phenotypic_class FBcv:0007503 abnormal long-term memory FBcv:0007503 Phenotype that is any abnormality in long-term memory (GO:0007616). 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.' ISBN:0582227089 http://hebb.mit.edu/courses/9.03/lecture4.html Phenotype that is any abnormality in body weight compared to identically raised wild-type controls. 2020-12-15T15:47:07Z phenotypic_class FBcv:0007504 abnormal body weight FBcv:0007504 Phenotype that is any abnormality in body weight compared to identically raised wild-type controls. FBC:CP Phenotype that is an increase in body weight compared to identically raised wild-type controls. 2020-12-15T15:50:18Z phenotypic_class FBcv:0007505 increased body weight FBcv:0007505 Phenotype that is an increase in body weight compared to identically raised wild-type controls. FBC:CP Phenotype that is a decrease in body weight compared to identically raised wild-type controls. 2020-12-15T15:50:44Z reduced body weight phenotypic_class FBcv:0007506 decreased body weight FBcv:0007506 Phenotype that is a decrease in body weight compared to identically raised wild-type controls. FBC:CP A phenotype that is an increase in the size of the whole body or some body part compared to wild-type. 2020-12-15T15:52:00Z phenotypic_class FBcv:0007507 increased size FBcv:0007507 A phenotype that is an increase in the size of the whole body or some body part compared to wild-type. FBC:CP A phenotype that is a decrease in the size of the whole body or some body part compared to wild-type. 2020-12-15T15:52:59Z reduced size phenotypic_class FBcv:0007508 decreased size FBcv:0007508 A phenotype that is a decrease in the size of the whole body or some body part compared to wild-type. FBC:CP Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.' 2020-12-16T09:10:39Z phenotypic_class FBcv:0007509 increased rate of phototaxis FBcv:0007509 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.' FBC:CP GOC:jl ISBN:0192800981 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.' 2020-12-16T09:20:20Z reduced rate of phototaxis phenotypic_class FBcv:0007510 decreased rate of phototaxis FBcv:0007510 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.' FBC:CP GOC:jl ISBN:0192800981 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.' 2020-12-16T09:21:22Z phenotypic_class FBcv:0007511 increased rate of cell adhesion FBcv:0007511 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.' FBC:CP GOC:hb GOC:pf Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.' 2020-12-16T09:22:22Z reduced rate of cell adhesion phenotypic_class FBcv:0007512 decreased rate of cell adhesion FBcv:0007512 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.' FBC:CP GOC:hb GOC:pf Phenotype that is an increase in the total amount or frequency of sleep (GO:0030431) over a given time interval, compared to wild-type. 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.' 2020-12-16T12:02:45Z phenotypic_class FBcv:0007513 increased sleep FBcv:0007513 Phenotype that is an increase in the total amount or frequency of sleep (GO:0030431) over a given time interval, compared to wild-type. 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.' FBC:CP ISBN:0192800981 Phenotype that is a decrease in the total amount or frequency of sleep (GO:0030431) over a given time interval, compared to wild-type. 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.' 2020-12-16T12:12:40Z reduced sleep phenotypic_class FBcv:0007514 decreased sleep FBcv:0007514 Phenotype that is a decrease in the total amount or frequency of sleep (GO:0030431) over a given time interval, compared to wild-type. 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.' FBC:CP ISBN:0192800981 Phenotype that is an increase in the total amount or frequency of feeding behavior (GO:0007631) over a given time interval, compared to wild-type. 'feeding behavior' is defined as: 'Behavior associated with the intake of food.' 2020-12-16T12:14:26Z phenotypic_class FBcv:0007515 increased rate of feeding behavior FBcv:0007515 Phenotype that is an increase in the total amount or frequency of feeding behavior (GO:0007631) over a given time interval, compared to wild-type. 'feeding behavior' is defined as: 'Behavior associated with the intake of food.' FBC:DOS GOC:mah Phenotype that is a decrease in the total amount or frequency of feeding behavior (GO:0007631) over a given time interval, compared to wild-type. 'feeding behavior' is defined as: 'Behavior associated with the intake of food.' 2020-12-16T12:16:19Z reduced rate of feeding behavior phenotypic_class FBcv:0007516 decreased rate of feeding behavior FBcv:0007516 Phenotype that is a decrease in the total amount or frequency of feeding behavior (GO:0007631) over a given time interval, compared to wild-type. 'feeding behavior' is defined as: 'Behavior associated with the intake of food.' FBC:DOS GOC:mah Phenotype that is an increase in the efficacy of memory (GO:0007613) relative to controls. 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).' 2021-08-06T11:45:09Z improved memory phenotypic_class FBcv:0007517 This will usually be measured as an increased magnitude/rate of a behavioral output associated with memory formation. increased efficacy of memory FBcv:0007517 Phenotype that is an increase in the efficacy of memory (GO:0007613) relative to controls. 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).' FBC:CP GOC:curators ISBN:0582227089 Phenotype that is a decrease in the efficacy of memory (GO:0007613) relative to controls. 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).' 2021-08-06T11:55:18Z impaired memory reduced efficacy of memory phenotypic_class FBcv:0007518 This will usually be measured as a decreased magnitude/rate of a behavioral output associated with memory formation. decreased efficacy of memory FBcv:0007518 Phenotype that is a decrease in the efficacy of memory (GO:0007613) relative to controls. 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).' FBC:CP GOC:curators ISBN:0582227089 Phenotype that is an increase in the efficacy of short-term memory (GO:0007614) relative to controls. 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.' 2021-08-06T11:56:41Z phenotypic_class FBcv:0007519 This will usually be measured as an increased magnitude/rate of a behavioral output associated with short-term memory formation. increased efficacy of short-term memory FBcv:0007519 Phenotype that is an increase in the efficacy of short-term memory (GO:0007614) relative to controls. 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.' FBC:CP ISBN:0582227089 http://hebb.mit.edu/courses/9.03/lecture4.html Phenotype that is a decrease in the efficacy of short-term memory (GO:0007614) relative to controls. 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.' 2021-08-06T11:57:17Z reduced efficacy of short-term memory phenotypic_class FBcv:0007520 This will usually be measured as a decreased magnitude/rate of a behavioral output associated with short-term memory formation. decreased efficacy of short-term memory FBcv:0007520 Phenotype that is a decrease in the efficacy of short-term memory (GO:0007614) relative to controls. 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.' FBC:CP ISBN:0582227089 http://hebb.mit.edu/courses/9.03/lecture4.html Phenotype that is an increase in the efficacy of long-term memory (GO:0007616) relative to controls. 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.' 2021-08-06T12:02:59Z phenotypic_class FBcv:0007521 This will usually be measured as an increased magnitude/rate of a behavioral output associated with long-term memory formation. increased efficacy of long-term memory FBcv:0007521 Phenotype that is an increase in the efficacy of long-term memory (GO:0007616) relative to controls. 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.' FBC:CP ISBN:0582227089 http://hebb.mit.edu/courses/9.03/lecture4.html Phenotype that is a decrease in the efficacy of long-term memory (GO:0007616) relative to controls. 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.' 2021-08-06T12:04:30Z reduced efficacy of long-term memory phenotypic_class FBcv:0007522 This will usually be measured as a decreased magnitude/rate of a behavioral output associated with long-term memory formation. decreased efficacy of long-term memory FBcv:0007522 Phenotype that is a decrease in the efficacy of long-term memory (GO:0007616) relative to controls. 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.' FBC:CP ISBN:0582227089 http://hebb.mit.edu/courses/9.03/lecture4.html Phenotype that is an increase in the efficacy of anesthesia-resistant memory (GO:0007615) relative to controls. 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.' 2021-08-06T12:08:22Z phenotypic_class FBcv:0007523 This will usually be measured as an increased magnitude/rate of a behavioral output associated with anesthesia-resistant memory formation. increased efficacy of anesthesia-resistant memory FBcv:0007523 Phenotype that is an increase in the efficacy of anesthesia-resistant memory (GO:0007615) relative to controls. 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.' FBC:CP PMID:15143285 PMID:17088531 Phenotype that is a decrease in the efficacy of anesthesia-resistant memory (GO:0007615) relative to controls. 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.' 2021-08-06T12:10:03Z reduced efficacy of anesthesia-resistant memory phenotypic_class FBcv:0007524 This will usually be measured as a decreased magnitude/rate of a behavioral output associated with anesthesia-resistant memory formation. decreased efficacy of anesthesia-resistant memory FBcv:0007524 Phenotype that is a decrease in the efficacy of anesthesia-resistant memory (GO:0007615) relative to controls. 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.' FBC:CP PMID:15143285 PMID:17088531 Phenotype that is an increase in the efficacy of medium-term memory (GO:0072375) relative to controls. 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).' 2021-08-06T12:11:31Z phenotypic_class FBcv:0007525 This will usually be measured as an increased magnitude/rate of a behavioral output associated with medium-term memory formation. increased efficacy of medium-term memory FBcv:0007525 Phenotype that is an increase in the efficacy of medium-term memory (GO:0072375) relative to controls. 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).' FBC:CP GOC:sart PMID:14659098 PMID:7923375 Phenotype that is a decrease in the efficacy of medium-term memory (GO:0072375) relative to controls. 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).' 2021-08-06T12:12:48Z reduced efficacy of medium-term memory phenotypic_class FBcv:0007526 This will usually be measured as a decreased magnitude/rate of a behavioral output associated with medium-term memory formation. decreased efficacy of medium-term memory FBcv:0007526 Phenotype that is a decrease in the efficacy of medium-term memory (GO:0072375) relative to controls. 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).' FBC:CP GOC:sart PMID:14659098 PMID:7923375 Any abnormality in adult walking behavior (GO:0007628), which is defined as 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'. 2022-08-12T08:45:06Z phenotypic_class FBcv:0007527 abnormal adult walking behavior FBcv:0007527 Any abnormality in adult walking behavior (GO:0007628), which is defined as 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'. GO:0007628 GOC:jid GOC:pr ISBN:0198606907 Any abnormality in larval locomotory behavior (GO:0008345), which is defined as 'Locomotory behavior in a larval (immature) organism.'. 2022-08-12T08:46:33Z phenotypic_class FBcv:0007528 abnormal larval locomotory behavior FBcv:0007528 Any abnormality in larval locomotory behavior (GO:0008345), which is defined as 'Locomotory behavior in a larval (immature) organism.'. GO:0008345 GOC:ai Any abnormality in adult locomotory behavior (GO:0008344), which is defined as 'Locomotory behavior in a fully developed and mature organism.'. 2022-08-12T08:50:44Z phenotypic_class FBcv:0007529 abnormal adult locomotory behavior FBcv:0007529 Any abnormality in adult locomotory behavior (GO:0008344), which is defined as 'Locomotory behavior in a fully developed and mature organism.'. GO:0008344 GOC:ai Phenotype that is an increase in the efficacy of learning (GO:0007612), relative to controls. 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.' 2022-08-12T08:57:36Z improved learning phenotypic_class FBcv:0007530 increased efficacy of learning FBcv:0007530 Phenotype that is an increase in the efficacy of learning (GO:0007612), relative to controls. 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.' ISBN:0582227089 ISBN:0721662544 Phenotype that is a decrease in the efficacy of learning (GO:0007612), relative to controls. 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.' 2022-08-12T09:06:29Z impaired learning reduced efficacy of learning phenotypic_class FBcv:0007531 decreased efficacy of learning FBcv:0007531 Phenotype that is a decrease in the efficacy of learning (GO:0007612), relative to controls. 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.' ISBN:0582227089 ISBN:0721662544 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'. 2022-08-12T10:04:22Z increased rate of chemosensitive behavior phenotypic_class FBcv:0007532 increased rate of chemosensory behavior FBcv:0007532 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'. GO:0007635 GOC:go_curators Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'. 2022-08-12T10:14:45Z phenotypic_class FBcv:0007533 increased rate of proboscis extension reflex FBcv:0007533 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'. FB:FBrf0044924 GO:0007637 GOC:jid Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'. 2022-08-12T10:16:08Z phenotypic_class FBcv:0007534 increased rate of grooming behavior FBcv:0007534 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'. GO:0007625 GOC:jl GOC:pr Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'. 2022-08-12T10:19:14Z phenotypic_class FBcv:0007535 increased rate of locomotory behavior FBcv:0007535 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'. GO:0007626 GOC:dph Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of adult walking behavior (GO:0007628). 'adult walking behavior' is defined as: 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'. 2022-08-12T10:20:31Z phenotypic_class FBcv:0007536 increased rate of adult walking behavior FBcv:0007536 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of adult walking behavior (GO:0007628). 'adult walking behavior' is defined as: 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'. GO:0007628 GOC:jid GOC:pr ISBN:0198606907 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of larval locomotory behavior (GO:0008345). 'larval locomotory behavior' is defined as: 'Locomotory behavior in a larval (immature) organism.'. 2022-08-12T10:21:27Z phenotypic_class FBcv:0007537 increased rate of larval locomotory behavior FBcv:0007537 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of larval locomotory behavior (GO:0008345). 'larval locomotory behavior' is defined as: 'Locomotory behavior in a larval (immature) organism.'. GO:0008345 GOC:ai Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of adult locomotory behavior (GO:0008344). 'adult locomotory behavior' is defined as: 'Locomotory behavior in a fully developed and mature organism.'. 2022-08-12T10:22:30Z phenotypic_class FBcv:0007538 increased rate of adult locomotory behavior FBcv:0007538 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of adult locomotory behavior (GO:0008344). 'adult locomotory behavior' is defined as: 'Locomotory behavior in a fully developed and mature organism.'. GO:0008344 GOC:ai Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'. 2022-08-12T10:23:15Z phenotypic_class FBcv:0007539 increased rate of mating behavior FBcv:0007539 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'. GO:0007617 GOC:ai GOC:dph Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'. 2022-08-12T10:23:56Z phenotypic_class FBcv:0007540 increased rate of courtship behavior FBcv:0007540 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'. GO:0007619 GOC:ai GOC:dph Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of flight behavior (GO:0007629). 'flight behavior' is defined as: 'The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air.'. 2022-08-12T10:25:01Z phenotypic_class FBcv:0007541 increased rate of flight behavior FBcv:0007541 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of flight behavior (GO:0007629). 'flight behavior' is defined as: 'The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air.'. GO:0007629 GOC:jid ISBN:0198606907 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of jump response (GO:0007630). 'jump response' is defined as: 'The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.'. 2022-08-12T10:25:43Z phenotypic_class FBcv:0007542 increased rate of jump response FBcv:0007542 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of jump response (GO:0007630). 'jump response' is defined as: 'The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.'. GO:0007630 GOC:jid ISBN:0198606907 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'. 2022-08-12T10:26:28Z phenotypic_class FBcv:0007543 increased rate of copulation FBcv:0007543 Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'. GO:0007620 ISBN:0721662544 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'. 2022-08-12T10:30:08Z decreased rate of chemosensitive behavior reduced rate of chemosensory behavior phenotypic_class FBcv:0007544 decreased rate of chemosensory behavior FBcv:0007544 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'. GO:0007635 GOC:go_curators Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'. 2022-08-12T10:30:42Z reduced rate of proboscis extension reflex phenotypic_class FBcv:0007545 decreased rate of proboscis extension reflex FBcv:0007545 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'. FB:FBrf0044924 GO:0007637 GOC:jid Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'. 2022-08-12T10:31:07Z reduced rate of grooming behavior phenotypic_class FBcv:0007546 decreased rate of grooming behavior FBcv:0007546 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'. GO:0007625 GOC:jl GOC:pr Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'. 2022-08-12T10:31:37Z reduced rate of locomotory behavior phenotypic_class FBcv:0007547 decreased rate of locomotory behavior FBcv:0007547 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'. GO:0007626 GOC:dph Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of adult walking behavior (GO:0007628). 'adult walking behavior' is defined as: 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'. 2022-08-12T10:31:54Z reduced rate of adult walking behavior phenotypic_class FBcv:0007548 decreased rate of adult walking behavior FBcv:0007548 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of adult walking behavior (GO:0007628). 'adult walking behavior' is defined as: 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'. GO:0007628 GOC:jid GOC:pr ISBN:0198606907 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of larval locomotory behavior (GO:0008345). 'larval locomotory behavior' is defined as: 'Locomotory behavior in a larval (immature) organism.'. 2022-08-12T10:32:11Z reduced rate of larval locomotory behavior phenotypic_class FBcv:0007549 decreased rate of larval locomotory behavior FBcv:0007549 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of larval locomotory behavior (GO:0008345). 'larval locomotory behavior' is defined as: 'Locomotory behavior in a larval (immature) organism.'. GO:0008345 GOC:ai Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of adult locomotory behavior (GO:0008344). 'adult locomotory behavior' is defined as: 'Locomotory behavior in a fully developed and mature organism.'. 2022-08-12T10:32:30Z reduced rate of adult locomotory behavior phenotypic_class FBcv:0007550 decreased rate of adult locomotory behavior FBcv:0007550 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of adult locomotory behavior (GO:0008344). 'adult locomotory behavior' is defined as: 'Locomotory behavior in a fully developed and mature organism.'. GO:0008344 GOC:ai Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'. 2022-08-12T10:32:56Z reduced rate of mating behavior phenotypic_class FBcv:0007551 decreased rate of mating behavior FBcv:0007551 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'. GO:0007617 GOC:ai GOC:dph Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'. 2022-08-12T10:33:17Z reduced rate of courtship behavior phenotypic_class FBcv:0007552 decreased rate of courtship behavior FBcv:0007552 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'. GO:0007619 GOC:ai GOC:dph Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of flight behavior (GO:0007629). 'flight behavior' is defined as: 'The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air.'. 2022-08-12T10:33:37Z reduced rate of flight behavior phenotypic_class FBcv:0007553 decreased rate of flight behavior FBcv:0007553 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of flight behavior (GO:0007629). 'flight behavior' is defined as: 'The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air.'. GO:0007629 GOC:jid ISBN:0198606907 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of jump response (GO:0007630). 'jump response' is defined as: 'The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.'. 2022-08-12T10:33:59Z reduced rate of jump response phenotypic_class FBcv:0007554 decreased rate of jump response FBcv:0007554 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of jump response (GO:0007630). 'jump response' is defined as: 'The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.'. GO:0007630 GOC:jid ISBN:0198606907 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'. 2022-08-12T10:34:20Z reduced rate of copulation phenotypic_class FBcv:0007555 decreased rate of copulation FBcv:0007555 Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'. GO:0007620 ISBN:0721662544 A method for quantifying the transcriptome of individual cells, in which transcripts isolated from single cells are subjected to high-throughput sequencing and mapping to a reference genome. 2021-07-26T12:18:07Z EFO:0008913 OBI:0002631 scRNA-Seq single-cell RNA sequencing assay assay_type FBcv:0009000 single-cell RNA-Seq FBcv:0009000 A method for quantifying the transcriptome of individual cells, in which transcripts isolated from single cells are subjected to high-throughput sequencing and mapping to a reference genome. PMID:28821273 scRNA-Seq PMID:32405060 A method for quantifying the transcriptome of individual cells, in which transcripts isolated from single nuclei are subjected to high-throughput sequencing and mapping to a reference genome. 2021-07-26T12:19:45Z EFO:0009809 single-nucleus RNA sequencing assay snRNA-Seq assay_type FBcv:0009001 single-nucleus RNA-Seq FBcv:0009001 A method for quantifying the transcriptome of individual cells, in which transcripts isolated from single nuclei are subjected to high-throughput sequencing and mapping to a reference genome. PMID:28821273 snRNA-Seq PMID:32405060 A result that groups individual cells into populations sharing a similar transcriptional profile. 2021-07-26T12:21:05Z result_type FBcv:0009002 cell clustering analysis FBcv:0009002 A result that groups individual cells into populations sharing a similar transcriptional profile. PMID:28821273 A result that represents a population of cells sharing a similar transcriptional profile. 2021-07-26T12:22:16Z result_type FBcv:0009003 transcriptional cell cluster FBcv:0009003 A result that represents a population of cells sharing a similar transcriptional profile. PMID:28821273 A biosample containing dissociated cell nuclei isolated from the organism. 2021-07-26T12:23:17Z biosample_type FBcv:0009004 isolated nuclei FBcv:0009004 A biosample containing dissociated cell nuclei isolated from the organism. FBC:DPG A method to prepare and sequence a library of cDNAs obtained from single cells. 2021-07-26T13:40:26Z assay_attribute FBcv:0009005 single-cell library sequencing FBcv:0009005 A method to prepare and sequence a library of cDNAs obtained from single cells. FBC:DPG A method that uses the DROP-Seq platform (Macosko et al., 2015) to prepare and sequence a cDNA library. 2021-07-26T13:41:58Z assay_attribute FBcv:0009006 DROP-Seq FBcv:0009006 A method that uses the DROP-Seq platform (Macosko et al., 2015) to prepare and sequence a cDNA library. PMID:26000488 A method that uses the Smart-seq2 platform (Picelli et al., 2013) to prepare and sequence a cDNA library. 2021-07-26T13:44:02Z assay_attribute FBcv:0009007 Smart-seq2 FBcv:0009007 A method that uses the Smart-seq2 platform (Picelli et al., 2013) to prepare and sequence a cDNA library. PMID:24056875 A method that uses the Chromium platform from 10x Genomics to prepare and sequence a cDNA library. 2021-07-26T13:45:06Z assay_attribute FBcv:0009008 10x sequencing FBcv:0009008 A method that uses the Chromium platform from 10x Genomics to prepare and sequence a cDNA library. PMID:29126257 A sample in which individuals have been deprived of food. 2022-02-03T18:11:36Z biosample_attribute FBcv:0009009 starvation FBcv:0009009 A sample in which individuals have been deprived of food. FBC:DPG A sample in which a biological specimen has been separated into individual cells. 2022-02-16T14:12:02Z EFO:0009091 biosample_attribute FBcv:0009010 cell dissociation FBcv:0009010 A sample in which a biological specimen has been separated into individual cells. EFO:0009091 A sample in which a biological specimen has been separated into individual cells by applying mechanical forces. 2022-02-16T14:14:12Z EFO:0009129 biosample_attribute FBcv:0009011 mechanical cell dissociation FBcv:0009011 A sample in which a biological specimen has been separated into individual cells by applying mechanical forces. EFO:0009129 A sample in which a biological specimen has been separated into individual cells by using enzymes. 2022-02-16T14:16:03Z EFO:0009128 biosample_attribute FBcv:0009012 enzymatic cell dissociation FBcv:0009012 A sample in which a biological specimen has been separated into individual cells by using enzymes. EFO:0009128 A sample in which a biological specimen has been separated into individual cells by using non-enzymatic chemicals. 2022-02-16T14:19:01Z EFO:0011026 biosample_attribute FBcv:0009013 chemical cell dissociation FBcv:0009013 A sample in which a biological specimen has been separated into individual cells by using non-enzymatic chemicals. EFO:0011026 Experimental treatment method that a biosample has been subjected to. 2022-02-17T13:55:39Z biosample_attribute FBcv:0009014 biosample treatment method FBcv:0009014 Experimental treatment method that a biosample has been subjected to. FBC:DPG Method pertaining to the collection or isolation of a biosample. 2022-02-17T14:12:00Z biosample_attribute FBcv:0009015 biosample preparation method FBcv:0009015 Method pertaining to the collection or isolation of a biosample. FBC:DPG Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated in response to a particular stimulus. 2023-02-23T14:00:00Z conditional gene product degradation tag experimental_tool_descriptor FBcv:0009016 conditional degradation tag FBcv:0009016 Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated in response to a particular stimulus. FBC:GM A result that provides the expression values for all (or some subset of) genes in a given biological sample containing cells of a single cell type. 2023-02-24T19:07:31Z result_type FBcv:0009017 cell type-specific gene expression profile FBcv:0009017 A result that provides the expression values for all (or some subset of) genes in a given biological sample containing cells of a single cell type. FBC:DPG An analysis that results from the sequencing of RNAs from multiple highly purified samples. 2023-02-24T19:16:13Z result_type FBcv:0009018 cell type-specific RNA-sequencing analysis FBcv:0009018 An analysis that results from the sequencing of RNAs from multiple highly purified samples. FBC:DPG Nuclei of a single cell type have been isolated with the INTACT (Isolation of Nuclei TAgged in a specific Cell Type) strategy (Henry et al., 2012). 2023-02-24T19:27:43Z biosample_attribute FBcv:0009019 INTACT nuclei isolation FBcv:0009019 Nuclei of a single cell type have been isolated with the INTACT (Isolation of Nuclei TAgged in a specific Cell Type) strategy (Henry et al., 2012). FlyBase:FBrf0219710 Nuclei of a single cell type have been isolated with the TAPIN (Tandem Affinity Purification of Intact Nuclei) strategy (Davis et al., 2020). 2023-02-24T19:29:12Z TAPIN-seq biosample_attribute FBcv:0009020 TAPIN nuclei isolation FBcv:0009020 Nuclei of a single cell type have been isolated with the TAPIN (Tandem Affinity Purification of Intact Nuclei) strategy (Davis et al., 2020). FlyBase:FBrf0244935 TAPIN-seq FlyBase:FBrf0244935 Material that is derived from the isolation of RNA from nuclei. 2023-02-24T19:33:34Z assay_attribute FBcv:0009021 nuclear RNA isolation FBcv:0009021 Material that is derived from the isolation of RNA from nuclei. FBC:DPG Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to modify a gene product of interest in a defined manner. 2023-03-24T18:05:17Z experimental_tool_descriptor FBcv:0009022 gene product engineering tool FBcv:0009022 Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to modify a gene product of interest in a defined manner. FBC:GM An enzyme that catalyzes hydrolysis of a peptide bond. 2023-03-24T18:18:03Z peptidase experimental_tool_descriptor FBcv:0009023 protease FBcv:0009023 An enzyme that catalyzes hydrolysis of a peptide bond. GO:0008233 peptidase FBC:GM A recognition site for a protease, an enzyme that catalyzes hydrolysis of a peptide bond. 2023-03-24T18:24:12Z experimental_tool_descriptor FBcv:0009024 protease target site FBcv:0009024 A recognition site for a protease, an enzyme that catalyzes hydrolysis of a peptide bond. FBC:GM A result that provides the expression values for all (or some subset of) genes in a given biological sample obtained using a specific transcriptional driver (or combination of drivers), when that driver is not associated to a clearly identified cell type. 2023-04-21T12:58:46Z result_type FBcv:0009025 driver-specific gene expression profile FBcv:0009025 A result that provides the expression values for all (or some subset of) genes in a given biological sample obtained using a specific transcriptional driver (or combination of drivers), when that driver is not associated to a clearly identified cell type. FBC:DPG A combination of two or more 'split system components' that together reconstitute a functional experimental tool. 2023-07-24T11:13:29Z experimental_tool_descriptor FBcv:0009026 split system combination FBcv:0009026 A combination of two or more 'split system components' that together reconstitute a functional experimental tool. FBC:GM Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments. 2023-07-31T17:10:54Z experimental_tool_descriptor FBcv:0009027 split driver fragment FBcv:0009027 Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments. FBC:GM Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus. 2023-07-31T17:13:57Z experimental_tool_descriptor FBcv:0009028 conditional split driver fragment FBcv:0009028 Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus. FBC:GM Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light. 2023-07-31T17:16:35Z experimental_tool_descriptor FBcv:0009029 light-regulated split driver fragment FBcv:0009029 Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light. FBC:GM Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated by binding to a small molecule, such as an ion or ligand. 2023-07-31T17:18:43Z small-molecule regulated split driver fragment experimental_tool_descriptor FBcv:0009030 small molecule-regulated split driver fragment FBcv:0009030 Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Catalytically inactive fragment of a protease. A functional protease can be reconstituted when complementary split protease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-05-03T13:12:34Z experimental_tool_descriptor FBcv:0009031 split protease FBcv:0009031 Catalytically inactive fragment of a protease. A functional protease can be reconstituted when complementary split protease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Catalytically inactive fragment of a bioluminescence reporter. A functional bioluminescence reporter can be reconstituted when complementary split bioluminescence reporter fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-05-03T13:17:31Z experimental_tool_descriptor FBcv:0009032 split bioluminescence reporter FBcv:0009032 Catalytically inactive fragment of a bioluminescence reporter. A functional bioluminescence reporter can be reconstituted when complementary split bioluminescence reporter fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Catalytically inactive fragment of a protease that can be used to reconstitute a functional protease when brought together in vivo with a complementary split protease fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus. 2024-05-29T10:04:16Z experimental_tool_descriptor FBcv:0009033 conditional split protease FBcv:0009033 Catalytically inactive fragment of a protease that can be used to reconstitute a functional protease when brought together in vivo with a complementary split protease fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus. FBC:GM Catalytically inactive fragment of a protease that can be used to reconstitute a functional protease when brought together in vivo with a complementary split protease fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light. 2024-05-29T10:06:15Z experimental_tool_descriptor FBcv:0009034 light-regulated split protease FBcv:0009034 Catalytically inactive fragment of a protease that can be used to reconstitute a functional protease when brought together in vivo with a complementary split protease fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light. FBC:GM Non-functional fragment of a cell ablation tool. A functional cell ablation tool can be reconstituted when complementary split cell ablation tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-05-29T10:09:01Z experimental_tool_descriptor FBcv:0009035 split cell ablation tool FBcv:0009035 Non-functional fragment of a cell ablation tool. A functional cell ablation tool can be reconstituted when complementary split cell ablation tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM A peptide sequence that can act as a recognition site for a protease (an enzyme that catalyzes hydrolysis of a peptide bond), where this property can be regulated in response to a particular stimulus. 2024-05-29T10:12:31Z experimental_tool_descriptor FBcv:0009036 conditional protease target site FBcv:0009036 A peptide sequence that can act as a recognition site for a protease (an enzyme that catalyzes hydrolysis of a peptide bond), where this property can be regulated in response to a particular stimulus. FBC:GM A peptide sequence that can act as a recognition site for a protease (an enzyme that catalyzes hydrolysis of a peptide bond), where this property can be regulated by irradiation with a pulse of light. 2024-05-29T10:13:50Z experimental_tool_descriptor FBcv:0009037 light-regulated protease target site FBcv:0009037 A peptide sequence that can act as a recognition site for a protease (an enzyme that catalyzes hydrolysis of a peptide bond), where this property can be regulated by irradiation with a pulse of light. FBC:GM An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated in response to a particular stimulus. 2024-06-24T10:42:33Z experimental_tool_descriptor FBcv:0009038 conditional RNA-guided nuclease FBcv:0009038 An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated in response to a particular stimulus. FBC:GM An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated by binding to a small molecule, such as an ion or ligand. 2024-06-24T10:44:12Z experimental_tool_descriptor FBcv:0009039 small molecule-regulated RNA-guided nuclease FBcv:0009039 An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product undergoing protein splicing. 2024-06-24T10:47:32Z experimental_tool_descriptor FBcv:0009040 protein splicing tag FBcv:0009040 Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product undergoing protein splicing. FBC:GM Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product undergoing protein splicing, where this process can be regulated in response to a particular stimulus. 2024-06-24T10:48:27Z experimental_tool_descriptor FBcv:0009041 conditional protein splicing tag FBcv:0009041 Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product undergoing protein splicing, where this process can be regulated in response to a particular stimulus. FBC:GM Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product undergoing protein splicing, where this process can be regulated by binding to a small molecule, such as an ion or ligand. 2024-06-24T10:49:38Z experimental_tool_descriptor FBcv:0009042 small molecule-regulated protein splicing tag FBcv:0009042 Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product undergoing protein splicing, where this process can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to regulate the viability of a specific cell or anatomical structure. 2024-06-24T11:04:56Z experimental_tool_descriptor FBcv:0009043 cell viability regulation tool FBcv:0009043 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to regulate the viability of a specific cell or anatomical structure. FBC:GM Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to inhibit cell death in a specific cell or anatomical structure. 2024-06-24T11:06:20Z experimental_tool_descriptor FBcv:0009044 cell death inhibition tool FBcv:0009044 Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to inhibit cell death in a specific cell or anatomical structure. FBC:GM Non-functional fragment of a genome engineering tool. A functional genome engineering tool can be reconstituted when complementary split genome engineering tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-06-24T11:11:57Z experimental_tool_descriptor FBcv:0009045 split genome engineering tool FBcv:0009045 Non-functional fragment of a genome engineering tool. A functional genome engineering tool can be reconstituted when complementary split genome engineering tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Non-functional fragment of a gene product engineering tool. A functional gene product engineering tool can be reconstituted when complementary split gene product engineering tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-06-24T11:13:39Z experimental_tool_descriptor FBcv:0009046 split gene product engineering tool FBcv:0009046 Non-functional fragment of a gene product engineering tool. A functional gene product engineering tool can be reconstituted when complementary split gene product engineering tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Non-functional fragment of a gene product detection tool. A functional gene product detection tool can be reconstituted when complementary split gene product detection tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-06-24T11:14:32Z experimental_tool_descriptor FBcv:0009047 split gene product detection tool FBcv:0009047 Non-functional fragment of a gene product detection tool. A functional gene product detection tool can be reconstituted when complementary split gene product detection tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Non-functional fragment of a protein detection tool. A functional protein detection tool can be reconstituted when complementary split protein detection tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-06-24T11:15:29Z experimental_tool_descriptor FBcv:0009048 split protein detection tool FBcv:0009048 Non-functional fragment of a protein detection tool. A functional protein detection tool can be reconstituted when complementary split protein detection tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Non-functional fragment of a cell viability regulation tool. A functional cell viability regulation tool can be reconstituted when complementary split cell viability regulation tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-06-24T11:16:29Z experimental_tool_descriptor FBcv:0009049 split cell viability regulation tool FBcv:0009049 Non-functional fragment of a cell viability regulation tool. A functional cell viability regulation tool can be reconstituted when complementary split cell viability regulation tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Non-functional fragment of a nuclease. A functional nuclease can be reconstituted when complementary split nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-06-24T11:30:43Z experimental_tool_descriptor FBcv:0009050 split nuclease FBcv:0009050 Non-functional fragment of a nuclease. A functional nuclease can be reconstituted when complementary split nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Non-functional fragment of an RNA-guided nuclease. A functional RNA-guided nuclease can be reconstituted when complementary split RNA-guided nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-06-24T11:31:36Z experimental_tool_descriptor FBcv:0009051 split RNA-guided nuclease FBcv:0009051 Non-functional fragment of an RNA-guided nuclease. A functional RNA-guided nuclease can be reconstituted when complementary split RNA-guided nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus. 2024-06-24T11:33:51Z experimental_tool_descriptor FBcv:0009052 conditional split RNA-guided nuclease FBcv:0009052 Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus. FBC:GM Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated by binding to a small molecule, such as an ion or ligand. 2024-06-24T11:35:10Z experimental_tool_descriptor FBcv:0009053 small molecule-regulated split RNA-guided nuclease FBcv:0009053 Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated by binding to a small molecule, such as an ion or ligand. FBC:GM Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and that can catalyze protein splicing when brought together with a complementary split protein splicing tag in vivo. Typically used to join two separate protein sequences by trans-splicing; in this case the two separate protein sequences are each initially tagged with one half of a pair of complementary split protein splicing tags. Alternatively, if both halves of a pair of complementary split protein splicing tags are used to tag each end of a single protein sequence, they can be used to generate a cyclized protein molecule. 2024-06-24T11:44:00Z experimental_tool_descriptor FBcv:0009054 split protein splicing tag FBcv:0009054 Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and that can catalyze protein splicing when brought together with a complementary split protein splicing tag in vivo. Typically used to join two separate protein sequences by trans-splicing; in this case the two separate protein sequences are each initially tagged with one half of a pair of complementary split protein splicing tags. Alternatively, if both halves of a pair of complementary split protein splicing tags are used to tag each end of a single protein sequence, they can be used to generate a cyclized protein molecule. FBC:GM Non-functional fragment of a specific binding tool. A functional specific binding tool can be reconstituted when complementary split specific binding tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. 2024-07-23T11:51:23Z experimental_tool_descriptor FBcv:0009055 split specific binding tool FBcv:0009055 Non-functional fragment of a specific binding tool. A functional specific binding tool can be reconstituted when complementary split specific binding tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact. FBC:GM A method that uses split-pool barcoding to unique label the mRNAs from a large number of single cells and sequence the resulting cDNA libraries (Cao et al., 2019). 2025-01-27T11:13:39Z sci-RNA-seq sci-RNA-seq3 assay_attribute FBcv:0009056 single-cell combinatorial indexing RNA sequencing FBcv:0009056 A method that uses split-pool barcoding to unique label the mRNAs from a large number of single cells and sequence the resulting cDNA libraries (Cao et al., 2019). PMID:28818938 A method, or a set of methods, used to analyze single-cell RNA-sequencing data and produce a cell-by-gene expression matrix. 2025-02-25T11:24:12Z result_attribute FBcv:0009057 single-cell RNA-sequencing analysis method FBcv:0009057 A method, or a set of methods, used to analyze single-cell RNA-sequencing data and produce a cell-by-gene expression matrix. FBC:DPG The single-cell RNA-sequencing analysis method used by the EMBL-EBI's Single-Cell Expression Atlas. 2025-02-25T11:42:22Z result_attribute FBcv:0009058 EMBL-EBI SCEA standard analysis method FBcv:0009058 The single-cell RNA-sequencing analysis method used by the EMBL-EBI's Single-Cell Expression Atlas. PMID:37992296 FlyBase miscellaneous CV FBcv:0010000 Consider - FBsv:0000002. obsolete living stock true FBcv:0010000 FlyBase miscellaneous CV FBcv:0010001 Consider - FBsv:0000003. obsolete molecular extract true FBcv:0010001 FlyBase miscellaneous CV FBcv:0010002 Consider - FBsv:0000005. obsolete preserved specimen true FBcv:0010002 FlyBase miscellaneous CV FBcv:0010003 obsolete E cytotype stock true FBcv:0010003 FlyBase miscellaneous CV FBcv:0010004 obsolete M cytotype stock true FBcv:0010004 FlyBase miscellaneous CV FBcv:0010005 Consider - FBsv:0000004. obsolete genomic DNA true FBcv:0010005 FlyBase miscellaneous CV FBcv:0010006 Consider - FBsv:0000007. obsolete ethanol-preserved specimen true FBcv:0010006 FlyBase miscellaneous CV FBcv:0010007 obsolete pinned specimen true FBcv:0010007 FlyBase miscellaneous CV FBcv:0010009 Consider - FBsv:0001010. obsolete fluorescent balancer true FBcv:0010009 FlyBase miscellaneous CV FBcv:0010010 Consider - FBsv:0001011. obsolete lacZ balancer true FBcv:0010010 FlyBase miscellaneous CV FBcv:0010011 obsolete laboratory wild-type stock true FBcv:0010011 FlyBase miscellaneous CV FBcv:0010012 Consider - FBsv:0000100. obsolete collection true FBcv:0010012 FlyBase miscellaneous CV FBcv:0010013 Consider - FBsv:0000101. obsolete stock center collection true FBcv:0010013 FlyBase miscellaneous CV FBcv:0010014 Consider - FBsv:0000102. obsolete laboratory collection true FBcv:0010014 FlyBase miscellaneous CV FBcv:0010015 obsolete Saxton laboratory true FBcv:0010015 FlyBase miscellaneous CV FBcv:0010016 Consider - FBsv:0000109. obsolete Garcia-Bellido laboratory true FBcv:0010016 FlyBase miscellaneous CV FBcv:0010017 Consider - FBsv:0000108. obsolete Nusslein-Volhard laboratory true FBcv:0010017 FlyBase miscellaneous CV FBcv:0010018 Consider - FBsv:0000110. obsolete Carpenter laboratory true FBcv:0010018 FlyBase miscellaneous CV Harvard Medical School Exelixis Drosophila Collection FBcv:0010019 obsolete Artavanis laboratory true FBcv:0010019 FlyBase miscellaneous CV Artavanis-Tsakonas laboratory FBcv:0010020 Consider - FBsv:0000105. obsolete Exelixis Drosophila Stock Collection at Harvard Medical School true FBcv:0010020 Bloomington FlyBase miscellaneous CV BDSC BSC FBcv:0010021 Consider - FBsv:0000103. obsolete Bloomington Drosophila Stock Center true FBcv:0010021 species stock center FlyBase miscellaneous CV Drosophila species stock center Tucson FBcv:0010022 Consider - FBsv:0000106. obsolete San Diego Drosophila Species Stock Center true FBcv:0010022 FlyBase miscellaneous CV Szeged FBcv:0010023 obsolete Szeged Drosophila Stock Centre true FBcv:0010023 FlyBase miscellaneous CV DGRC Kyoto Kyoto stock center FBcv:0010024 Consider - FBsv:0000104. obsolete Drosophila Genetic Resource Center true FBcv:0010024 UBERON:0001062 2025-05-30 a core relation that holds between a whole and its part has part a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence has role http://dx.doi.org/10.1186/2041-1480-4-30 http://orcid.org/0000-0002-1373-1705 http://orcid.org/0000-0002-7073-9172 https://orcid.org/0000-0001-5948-3092 https://orcid.org/0000-0002-0027-0858 A miscellaneous ontology of terms used for curation in FlyBase, including the DPO. https://creativecommons.org/licenses/by/4.0/ FlyBase Controlled Vocabulary (FBcv) 30:05:2025 10:40 FlyBase miscellaneous CV 1.2 2025-05-30 FlyBase miscellaneous CV conditionality conditionality