BD2D:Alcohol_Units Equivalence of number of alcohol units per drink. BD2D:Authors BD2D:CONTEXT BD2D:CT_Scans Automatically generated by OncoRadiomics SW (MAASTRO) BD2D:Cancer_Registries_Data BD2D:Clinical_T_and_N_Characteristics BD2D:Demographic_Clinical_Data BD2D:Follow_Up BD2D:Genes_Relevant_for_Prognosis Only genes relevant for prognosis. The rows in green (all this data) are repeated for each prognostic gene used by the models. BD2D:Genomic_Analysis BD2D:Genomic_Data BD2D:High_Resolution_Study BD2D:Imaging_Data BD2D:MRI_FOS BD2D:MRI_GLCM BD2D:MRI_GLRLM BD2D:MRI_SS BD2D:MRI_and_DWIMRI_Scans Automatically generated by the radiomics SW developed by POLIMI BD2D:Pathology_Data BD2D:Patient_Selection BD2D:Pilot_Study BD2D:Quality_of_Life BD2D:REFERENCES BD2D:Radiomics_Data BD2D:Toxicity_Data BD2D:Virtual_Patient Chemotherapy:Best_Tumor_Response Response Evaluation Criteria In Solid Tumors: A standard way to measure how well a cancer patient responds to treatment. It is based on whether tumors shrink, stay the same, or get bigger. To use Response Evaluation Criteria In Solid Tumors, there must be at least one tumor that can be measured on x-rays, CT scans, or MRI scans. The types of response a patient can have are a complete response (CR), a partial response (PR), progressive disease (PD), and stable disease (SD). Also called RECIST. Chemotherapy:Cancer_Therapy_Agent_Name List of anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. Chemotherapy:Chemotherapy_Treatment Treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemotherapy may be given by mouth, injection, or infusion, or on the skin, depending on the type and stage of the cancer being treated. It may be given alone or with other treatments, such as surgery, radiation therapy, or biologic therapy. Chemotherapy:Note_chemo Chemotherapy:Number_of_Cycles_Performed_1 Number of cycles performed during the chemotherapy treatment. Chemotherapy:Number_of_Cycles_Performed_2 Number of cycles performed during the chemotherapy treatment. Chemotherapy:Number_of_Cycles_Performed_3 Number of cycles performed during the chemotherapy treatment. Chemotherapy:Reason_for_Stopping_the_Treatment_1 Reason for stopping the chemotherapy treatment. Chemotherapy:Reason_for_Stopping_the_Treatment_2 Reason for stopping the chemotherapy treatment. Chemotherapy:Reason_for_Stopping_the_Treatment_3 Reason for stopping the chemotherapy treatment. Chemotherapy:Start_Date_of_First_Cycle_1 Start date of first cycle of the chemotherapy treatment. Chemotherapy:Start_Date_of_First_Cycle_2 Start date of first cycle of the chemotherapy treatment. Chemotherapy:Start_Date_of_First_Cycle_3 Start date of first cycle of the chemotherapy treatment. Chemotherapy:Stop_Date_of_Last_Cycle_1 Stop date of last cycle of the chemotherapy treatment. Chemotherapy:Stop_Date_of_Last_Cycle_2 Stop date of last cycle of the chemotherapy treatment. Chemotherapy:Stop_Date_of_Last_Cycle_3 Stop date of last cycle of the chemotherapy treatment. Chemotherapy:Target_Volume_to_be_irradiated_RT Indicates the total target volume to be irradiated, that is the sum of volumes of primary tumor and involved nodes. Expressed in cubic centimeter (cc). Chemotherapy:Total_Dose_throughout_Treatment_1 Number of total dose of chemotherapy agent throughout treatment. unit: (mg/m2) Chemotherapy:Total_Dose_throughout_Treatment_2 Number of total dose of chemotherapy agent throughout treatment. unit: (mg/m2) Chemotherapy:Total_Dose_throughout_Treatment_3 Number of total dose of chemotherapy agent throughout treatment. unit: (mg/m2) Chemotherapy:Treatment_Scheduled_1 Schedule of administration of chemotherapy drug. Chemotherapy:Treatment_Scheduled_2 Schedule of administration of chemotherapy drug. Chemotherapy:Treatment_Scheduled_3 Schedule of administration of chemotherapy drug. Chemotherapy:Type_of_CT Type of strategy used in chemotherapy. DemographicClinicalData:ASA ASA Physical Status Classification System is a system for assessing the fitness of patients before surgery. DemographicClinicalData:Age_at_Diagnosis Age of the patient when he/she was diagnosed with head and neck cancer. DemographicClinicalData:Clinical_Notes DemographicClinicalData:Date_of_Diagnosis_of_Positive_HIV Date when patient was diagnosed with HIV positive, expressed as DD/MM/YYYY. DemographicClinicalData:Date_of_first_Diagnosis Date when patient was first diagnosed with cancer (whether at its primary site or as a metastasis), expressed as DD/MM/YYYY. DemographicClinicalData:ECOG_Performance_Status Is a standard criteria for measuring how the disease impacts a patient’s daily living abilities (known to physicians and researchers as a patient’s performance status). It describes a patient’s level of functioning in terms of their ability to care for themself, daily activity, and physical ability (walking, working, etc.). The scale was developed by the Eastern Cooperative Oncology Group (ECOG), now part of the ECOG-ACRIN Cancer Research Group . DemographicClinicalData:Ethnicity A large group of people who have the same national, racial, or cultural origins, or the state of belonging to such a group. DemographicClinicalData:HB_Level Hemoglobin (sometimes abbreviated as HB) is a complex protein found in red blood cells that contains an iron molecule. The main function of hemoglobin is to carry oxygen from the lungs to the body tissues, and to exchange the oxygen for carbon dioxide, and then carry the carbon dioxide back to the lungs and where it is exchanged for oxygen. The iron molecule in hemoglobin helps maintain the normal shape of red blood cells. The hemoglobin test measures how much hemoglobin is in the blood. Normal values are 7.45 to 11 mmol/L. DemographicClinicalData:HB_Level_Total It is the HB level in mmol/L. This value is obtained after conversion of HB level from g/dL to mmol/L. DemographicClinicalData:HB_Level_Units Units of measurement of Hemoglobin (HB). DemographicClinicalData:HIV_Status Human Immunodeficiency Virus also called HIV is the virus that causes acquired immunodeficiency syndrome (AIDS). An HIV antibody test checks for HIV antibodies in a sample of blood, urine, or saliva. It can take from 2 weeks to 6 months after a person is infected with HIV before the antibodies are found with this test. It is the most common type of HIV test. DemographicClinicalData:Hospital A medical organization at which sick or injured people are given clinical care. DemographicClinicalData:Leukocytes A type of blood cell that is made in the bone marrow and found in the blood and lymph tissue. Leukocytes are part of the body’s immune system. They help the body fight infection and other diseases. Types of leukocytes are granulocytes (neutrophils, eosinophils, and basophils), monocytes, and lymphocytes (T cells and B cells). Checking the number of leukocytes in the blood is usually part of a complete blood cell (CBC) test. It may be used to look for conditions such as infection, inflammation, allergies, and leukemia. Also called WBC and white blood cell. DemographicClinicalData:Leukocytes_Total It is the leukocytes count in 10^9/L. This value is obtained after conversion of leukocytes from 10^3/µL to 10^9/L. DemographicClinicalData:Leukocytes_Units Units of measurement of Leukocytes. DemographicClinicalData:Local_Patient_ID Unique identification code from Hospital for each patient. DemographicClinicalData:Lymphocytes A type of immune cell that is made in the bone marrow and is found in the blood and in lymph tissue. The two main types of lymphocytes are B lymphocytes and T lymphocytes. B lymphocytes make antibodies, and T lymphocytes help kill tumor cells and help control immune responses. A lymphocyte is a type of white blood cell. DemographicClinicalData:Lymphocytes_Total It is the lymphocytes count in 10^9/L. This value is obtained after conversion of lymphocytes from 10^3/µL to 10^9/L. DemographicClinicalData:Lymphocytes_Units Units of measurement of Lymphocytes. DemographicClinicalData:Overall_Comorbidity_Score A 27-item comorbidity index for patients with cancer. The ACE‐27 allows accurate and efficient collection of comorbid health information. The ACE‐27 takes into consideration the severity of individual organ decompensation and the negative prognostic impact attributable to each comorbid ailment and categorizes comorbid conditions into one of three levels of comorbidity: grade 1 (mild), grade 2 (moderate), and grade 3 (severe). The single highest ranked comorbid ailment must be identified and used to calculate the final comorbidity score: none, 0; mild, 1; moderate, 2; or severe, 3. Overall Comorbidity Score is defined according to the highest ranked single ailment, except in the case where two or more Grade 2 ailments occur in different organ systems. In this situation, the overall comorbidity score should be designated Grade 3. DemographicClinicalData:PLT_Level A platelet (PLT) count is a lab test to measure the amount of platelets in the blood. Platelets are parts of the blood that helps the blood clot. They are smaller than red or white blood cells. The normal number of platelets in the blood is 150,000 to 400,000 platelets per microliter (mcL) or 150 to 400 × 10^9/L. DemographicClinicalData:PLT_Level_Total It is the PLT level in 10^9/L. This value is obtained after conversion of PLT level from 10^3/µL to 10^9/L. DemographicClinicalData:PLT_Level_Units Units of measurement of platelet (PLT) level. DemographicClinicalData:Patient_ID Unique identification code for each patient. DemographicClinicalData:Sex Sex refers to the biological characteristics that define humans as female or male. DemographicClinicalData:Year_of_Birth Year in which patient was born. Should be an integer number ≤ current year. DemographicClinicalData:Zubrod_Performance_Status A rating scale measuring the ability of a cancer patient to carry out the activities of daily living. The ranges are a score of 0 (fully active, unrestricted by disease) to 1 (able to carry out light work), 2 (ambulatory but resting for as much as 50% of the day), 3 (resting in bed or a chair for more than half the day), 4 (confined to bed at all times) and 5 (patient has died). cTN:Anatomical_Tumor_Location Tumor localization according to the ICD10-CM classification. cTN:Depth_of_Invasion_8Edition Indicates the depth range for tumor invasion in the oral cavity. Extracted from TNM 8th edition. cTN:Extension_to_lingual_surface_of_epiglottis_is_present Indicates whether or not the epiglottis is extended to the lingual surface in a tumor located in the oropharynx. cTN:Laterality_of_T Indicates the side of the body where the tumor is located. The possible options can be: left, right and midline. cTN:N_Side Indicates the position of the involved lymph nodes in relation to the primary tumor. The possible options can be: ipsilateral, contralateral and bilateral. cTN:Node_Levels_Left Localization in left side of body, of the involved lymph nodes based on the lymph node levels of the neck. cTN:Node_Levels_Right Localization in right side of body, of the involved lymph nodes based on the lymph node levels of the neck. cTN:Notes_ctn cTN:Stage_at_Diagnosis_7Edition Prognostic stage groups are assigned based on disease site-specific T, N, and M categories and relevant prognostic factors to group patients with similar prognosis and/or treatment approach. Indicates the stage group based on the AJCC 7th edition. The stage is calculated as follows: Stage 0 = Tis - N0 - M0 Stage I = T1 - N0 - M0 Stage II = T2 - N0 - M0 Stage III = T3 - N0 - M0 T1 - N1 - M0 T2 - N1 - M0 T3 - N1 - M0 Stage IVA = T4a - N0 - M0 T4a - N1 - M0 T1 - N2 - M0 T2 - N2 - M0 T3 - N2 - M0 T4a - N2 - M0 Stage IVB = Any T - N3 (7th Ed.)/N3a,b (8th Ed.) - M0 T4b - Any N - M0 Stage IVC = Any T - Any N - M1 cTN:Stage_at_Diagnosis_8Edition_OralCavity_Oropharynx_p16Negative_Hypopharynx_Larynx Prognostic stage groups are assigned based on disease site-specific T, N, and M categories and relevant prognostic factors to group patients with similar prognosis and/or treatment approach. Indicates the stage group based on the AJCC 8th edition for Oral Cavity, Oropharynx (p16-Negative), Hypopharynx and Larynx. The stage is calculated as follows: Stage 0 = Tis - N0 - M0 Stage I = T1 - N0 - M0 Stage II = T2 - N0 - M0 Stage III = T3 - N0 - M0 T1 - N1 - M0 T2 - N1 - M0 T3 - N1 - M0 Stage IVA = T4a - N0 - M0 T4a - N1 - M0 T1 - N2 - M0 T2 - N2 - M0 T3 - N2 - M0 T4a - N2 - M0 Stage IVB = Any T - N3 (7th Ed.)/N3a,b (8th Ed.) - M0 T4b - Any N - M0 Stage IVC = Any T - Any N - M1 cTN:Stage_at_Diagnosis_8Edition_Oropharynx_p16Positive Prognostic stage groups are assigned based on disease site-specific T, N, and M categories and relevant prognostic factors to group patients with similar prognosis and/or treatment approach. Indicates the stage group based on the AJCC 8th edition for Oropharynx (p16-Positive). The stage is calculated as follows: Stage 0 = Tis - N0 - M0 Stage I = T1 - N0 - M0 T2 - N0 - M0 T1 - N1 - M0 T2 - N1 - M0 Stage II = T3 - N0 - M0 T3 - N1 - M0 T1 - N2 - M0 T2 - N2 - M0 T3 - N2 - M0 Stage III = Any T - N3 - M0 T4 - Any N - M0 Stage IV = Any T - Any N - M1 cTN:T4_Oral_Cavity_classified_as_such_for_only_bone_erosion Indicates whether or not there is bone erosion in a tumor located in the oral cavity. cTN:TNM_cN_7Edition cTN:TNM_cN_8Edition_OralCavity_Oropharynx_p16Negative_Hypopharynx_Larynx cTN:TNM_cN_8Edition_Oropharynx_p16Positive Method used to determine the grade of a tumor for Oropharynx cancer p-16 positive (HPV positive) patients. cTN:TNM_cT_7Edition Neoplasm Staging - Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. The TNM staging system is a system to describe the amount and spread of cancer in a patient’s body, using TNM. T describes the size of the tumor and any spread of cancer into nearby tissue; N describes spread of cancer to nearby lymph nodes; and M describes metastasis (spread of cancer to other parts of the body). This system was created and is updated by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). The TNM staging system is used to describe most types of cancer. Also called AJCC staging system. This refer to the 7th edition published in 2009 and the effective dates for cancer diagnoses are 2010-2016. cTN:TNM_cT_8Edition_OralCavity_Oropharynx_p16Negative_Hypopharynx_Larynx The TNM staging system is a system to describe the amount and spread of cancer in a patient’s body, using TNM. T describes the size of the tumor and any spread of cancer into nearby tissue; N describes spread of cancer to nearby lymph nodes; and M describes metastasis (spread of cancer to other parts of the body). This system was created and is updated by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). The TNM staging system is used to describe most types of cancer. Also called AJCC staging system. This refer to the 8th edition published in 2016 and the effective dates for cancer diagnoses are from 2017. cTN:TNM_cT_8Edition_Oropharynx_p16Positive cTN:Tissue_Invasion_ExtraNodalExtension Invasion refers to the direct extension and penetration by cancer cells into neighbouring tissues. Indicates whether or not the tumor has spread beyond the outer margin of a lymph node. Extra-capsular extension of nodal tumor. cTN:Tissue_Invasion_ExtraNodalExtension_to Indicates which tissue have been invaded by the tumor once has spread beyond the outer margin of lymph node. The possible invaded tissues can be: skin, muscle, cranial nerve XI, brachial plexus and parotid gland. cTN:Tumor_Region Anatomical site of a tumor, where the tumor is localized. FollowUp:Date_of_Death Date of clinical death, expressed as DD/MM/YYYY. Related to Death (MeSH browser): https://meshb.nlm.nih.gov/record/ui?ui=D003643 FollowUp:Date_of_Examination_or_Last_Contact Date of last clinical encounter, expressed as DD/MM/YYYY. Related: https://ushik.ahrq.gov/ViewItemDetails?system=mdr&itemKey=74379000 FollowUp:Date_of_Recurrence Date when cancer has recurred, expressed as DD/MM/YYYY. FollowUp:Follow_Up_Period Period between date of diagnosis and date of the last encounter/office visit Made By Patients To Health Service Providers' Offices. Related to MeSH Browser: Office Visits Descriptor. FollowUp:Follow_Up_Period_Before_Recurrence Time (in months) between the date of first diagnosis and the date of recurrence. FollowUp:Primary_Cause_of_Death Main reason of patient death. Related to MeSH browser: cause of death https://meshb.nlm.nih.gov/record/ui?ui=D002423 FollowUp:Recurrence Cancer that has recurred (come back), usually after a period of time during which the cancer could not be detected. The cancer may come back to the same place as the original (primary) tumor or to another place in the body. Also called recurrent cancer. Reference: MeSH browser: https://meshb.nlm.nih.gov/record/ui?ui=D009364 FollowUp:Status_of_Patient Living condition for a patient. FollowUp:Treatment_Intention Purpose of apply treatment upon a patient. FollowUp:Treatment_of_Recurrence Treatment given for a patient with tumor recurrence. FollowUp:Type_of_Recurrence Type of cancer recurrence, based on the location of the tumor reapparance. GenesRelevantforPrognosis:Gene_Annotation_EntrezID GenesRelevantforPrognosis:Gene_Annotation_Gene_Symbol GenesRelevantforPrognosis:Genes_Reference_Gene_Normalized_Count GenesRelevantforPrognosis:Genes_Reference_Gene_Raw_Count GenesRelevantforPrognosis:Target_Gene_Name GenomicData:Analysis_ID Same as Unique Sample ID. GenomicData:Data_Processing_Date_of_Analysis GenomicData:Data_Processing_Operator_Name GenomicData:Genomic_Reference_Gene_Normalized_Count GenomicData:Genomic_Reference_Gene_Raw_Count GenomicData:Library_Construction_and_Sequencing_Date_of_Analysis GenomicData:Library_Construction_and_Sequencing_Operator_Name GenomicData:Processed_Data Processed data (Entire Gene Profiling) GenomicData:RNA_Extraction_Date_of_Analysis GenomicData:RNA_Extraction_Operator_Name GenomicData:Raw_Data_BAM_File Raw data (entire gene profiling) BAM file Binary format for storing sequence data Data storing (please be aware about the size) GenomicData:Raw_Data_FASTQ_File Raw data (entire gene profiling) FASTQ file Text-based format for storing both a biological sequence and its corresponding quality scores Data storing (please note be aware about the size) Imaging:Buccal_Fat_Invasion Indicates if tumor has invaded the buccal fat pad. Imaging:Carotid_Infiltration Indicates if tumor from the involved lymph node has infiltrated the carotid artery. Imaging:Case_Number_Image_ID Indicates the identifier for a diagnostic imaging study. Imaging:Central_Necrosis Presence or absence of death of the central part of a tissue or organ. Imaging:Cutaneous_Invasion Indicates if tumor has invaded the skin. Imaging:Cutaneous_Invasion_Skin Indicates if tumor from the involved lymph node has invaded the skin. Imaging:Date_of_Analysis Date on which an imaging procedure was performed for a patient. Expressed as DD/MM/YYYY. Imaging:ENS_Irregular_Margin_Edges It refers to the alteration of the surrounding fat/irregular margins edges in the lymph node. Imaging:Extension_Site Body site where the tumor spreads. The body site is determined according to the ICD10-CM classification. Imaging:Extra_Nodal_Spreading Presence of tumor extension beyond the lymph node capsule. Imaging:Extra_Tumor_Spreading Presence of tumor extension beyond the primary boundaries of an organ. Imaging:Extrinsic_Tongue_Musculature_Invasion Indicates if tumor has invaded the extrinsic muscles of the tongue, which all arise outside the tongue, which is in comparison to the intrinsic muscles of the tongue which are entirely within the tongue with no external attachments. The extrinsic tongue muscles are genioglossus muscle, hyoglossus muscle, styloglossus muscle and palatoglossus muscle. Imaging:Floor_of_the_Mouth_Invasion Indicates if tumor has invaded the floor of the mouth, that is the area of the mouth under the ventral surface of the tongue. Imaging:Image_Contrast Characteristic of imaging procedure. The contrast agent can be used or not to enhance the image. Imaging:Image_Site Tumor localization according to the ICD10-CM classification. Imaging:Image_Type Indicates the diagnostic imaging type used during the diagnosis procedure. Imaging:Internal_Carotid_Invasion Indicates if tumor has invaded the internal carotid. Imaging:Lymph_Bone_Infiltration Indicates if tumor from the involved lymph node has infiltrated the bone, which could be any bone adjacent to the involved lymph node. Imaging:Lymph_Contrast_Take_up_Rate Amount of contrast enhancement in lymph nodes, based on the difference between contrast and non contrast imaging. Imaging:Lymph_Major_Axis The largest cross sectional diameter of an involved lymph node. Imaging:Lymph_Minor_Axis The smalles cross sectional diameter of an involved lymph node. Imaging:Lymph_Necrosis Presence or not of necrosis within a lymph node. Imaging:Lymph_Side Position of the body where the lymph node is located. It could be the right or left side or in the midline. Imaging:Lymph_Site Localization of involved lymph nodes based on the lymph node levels of the neck. Imaging:Lymph_Volume The size of an involved lymph node, measured in mm^3. Imaging:Masticator_Space_Invasion Indicates if tumor has invaded the masticator space, which is the potential space containing the pterygoid and masseter muscles. Imaging:Maxillary_Sinus_Invasion Indicates if tumor has invaded the maxillary sinus, which is the pyramidal-shaped, thin-walled, air-filled cavity located in the maxilla. Imaging:Number_of_Lymph_Nodes_Involved Reports the presence and the number of involved lymph nodes. Imaging:Orbital_Invasion Indicates if tumor has invaded the orbit, which is the bony cavity of the skull which contains the eye, anterior portion of the optic nerve, ocular muscles and ocular adnexa. Imaging:Oropharynx_Invasion Indicates if tumor has invaded the oropharynx, which is the part of the pharynx between the soft palate and the upper portion of the epiglottis. Imaging:Parapharyngeal_Space_Invasion Indicates if tumor has invaded the parapharyngeal space. The parapharyngeal space is the potential space of the neck, which is bounded superiorly by the base of the skull, inferiorly by the greater cornu of the hyoid bone, anteriorly by the investing fascia of the deep cervical fascia covering the medial pterygoid muscle, posteriorly by the prevertebral layer of the deep cervical fascia, medially by the middle (pretracheal) layer of the deep cervical fascia, and laterally by the investing fascia of the deep cervical fascia covering the deep lobe of the parotid. Imaging:Perineural_Infiltration Indicates if tumor has invaded the nerve fibers or is around a nerve or group of nerves. Imaging:Periosteal_Infiltration Indicates if tumor has infiltrated the periosteum. Imaging:Pterygo_Invasion Indicates if tumor has invaded the pterygoid muscle. Imaging:Pterygo_Palatine_Invasion Indicates if tumor has invaded the pterygopalatine fossa. Imaging:Retromolar_Area_Invasion Indicates if tumor has invaded the retromolar trigone, which is the triangular-shaped area of mucosa located posterior the last mandibular molar tooth. Imaging:Selected_Images A number of images selected by the radiologist to use for analysis. Imaging:Shape_Deviation Imaging:Side_Relative_to_Tumour Position of the involved lymph nodes in relation to the primary tumor. Imaging:Skull_Base_Invasion Indicates if tumor has invaded the base of skull, which is the portion of the skull that forms the floor on which the brain lies. Imaging:Spread_Across_Midline A response that indicates whether the tumor spreading has occurred through the midline of body. Imaging:Stage_Grouping An assessment based on the combined evaluation of the patient's T stage, M stage, and N stage, as well as prognostic parameters for specific cancers. See TNM staging system for each anatomic (sub)site. Imaging:TNM_Radiological_M Presence or absence of distant tumor spreading based on diagnostic imaging, defined for each anatomic (sub)site in the TNM staging system. Imaging:TNM_Radiological_N Extension of nodal tumor involvement based on diagnostic imaging, defined for each anatomic (sub)site in the TNM staging system. Imaging:TNM_Radiological_T Extension of primary tumor based on diagnostic imaging, defined for each anatomic (sub)site in the TNM staging system. Imaging:Tumor_Bone_Infiltration Indicates if the primary tumor has infiltrated the bone , which could be any bone adjacent to the primary tumor. For head and neck cancers most important bones for infiltration are the mandible, maxilla and skull base. Imaging:Tumor_Contrast_Take_up_Rate Amount of contrast enhancement, based on the difference between contrast and non contrast imaging. Imaging:Tumor_Major_Axis The largest cross sectional diameter of a primary tumor. Imaging:Tumor_Minor_Axis The smalles cross sectional diameter of a primary tumor. Imaging:Tumor_Necrosis Presence or not of necrosis within a tumor. Imaging:Tumor_Side Position of the body where the tumor is located. It could be the right or left side or in the midline. Imaging:Tumor_Site Tumor localization according to the ICD10-CM classification. ICD10-CM is a classification of neoplasms, whether are functionally active or not. The classification is primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. Imaging:Tumor_Thickness_Staging Classification of primary tumor thickness. Imaging:Tumor_Volume The size of a cancer measured by the amount of space taken up by the primary tumor, measured in mm^3. The volume is automatically calculated based on tumor contouring. PathologyData:Basaloid_features Morphological features of the tumors cells resembling those of cells from the basal (deep) layers of a squamous epithelium. PathologyData:Date_of_Pathology_Report The written and signed form of a pathological diagnosis. PathologyData:Degree_of_Cell_Keratinisation The amount of keratin produced by a squamous cell carcinoma. It is an index of cell differentiation. PathologyData:Depth_of_Invasion The value in millimeters (mm) of the depth of tissue invasion as measured perpendicularly from the line of the epithelial-stromal interface of the adjacent squamous mucosa to the deepest part of the tumor; it excludes any exophytic component. PathologyData:Extracapsular_Spread It indicates whether or not there is tumor spread beyond the lymphnode capsule. PathologyData:Grade_at_Diagnosis A measure of the tumor cell differentiation as compared to the normal reference tissue according to WHO criteria. PathologyData:HPV_DNA Indicates whether or not there is presence of DNA of Human Papillomavirus in tumor tissue. PathologyData:HPV_Status Indicates whether or not Human papillomavirus (HPV) was detected in a tumor sample as assessed either directly by HPV DNA/RNA test or indirectly through p16ink4a immunostain. PathologyData:HPV_Testing Indicates which method was used to assess the presence of Human Papillomavirus (HPV) DNA or RNA transcripts in a tumor sample. Accepted methods are: polymerase chain reaction (PCR), reverse transcription- polymerase chain reaction (RT-PCR), and in situ hybridization (ISH). PathologyData:Left_Side_Level_I Indicates the number of involved metastatic lymph nodes on the left side of level I of the neck. PathologyData:Left_Side_Level_II Indicates the number of involved metastatic lymph nodes on the left side of level II of the neck. PathologyData:Left_Side_Level_III Indicates the number of involved metastatic lymph nodes on the left side of level III of the neck. PathologyData:Left_Side_Level_IV Indicates the number of involved metastatic lymph nodes on the left side of level IV of the neck. PathologyData:Left_Side_Level_V Indicates the number of involved metastatic lymph nodes on the left side of level V of the neck. PathologyData:Level_of_Invasion The anatomical level of tumor invasion in adjacent tissues. PathologyData:Lympho_Plasmacytic_Reaction The degree of the lympho-plasmacellular reaction as assessed mainly at the tumor-stroma interface; this is a favourable prognostic variable. The possible values can be: none, mild, moderate, marked or not evaluable. PathologyData:Lympho_Vascular_Invasion The presence of tumor cells within small vessels, either lymphatic or blood vessels. PathologyData:Nuclear_Pleomorphism The degree of variation in size, form or chromatin texture, shown by the nuclei of tumor cells. PathologyData:Pathology_Case_Number The number of the pathology report that refers to the tissue specimen used for the evaluation of the pathological data. PathologyData:Pattern_of_Invasion The pattern of growth of the tumor at the front of invasion. The possible categories can be: cohesive, focal non cohesive, extensive non cohesive or not evaluable. The worst pattern of invasion is a validated outcome for oral SCC patients. PathologyData:Perineural_Invasion The presence of tumor cells within the perineural layer of a nerve, either named (should be specified) or unnamed. PathologyData:Right_Side_Level_I Indicates the number of involved metastatic lymph nodes on the right side of level I of the neck. PathologyData:Right_Side_Level_II Indicates the number of involved metastatic lymph nodes on the right side of level II of the neck. PathologyData:Right_Side_Level_III Indicates the number of involved metastatic lymph nodes on the right side of level III of the neck. PathologyData:Right_Side_Level_IV Indicates the number of involved metastatic lymph nodes on the right side of level IV of the neck. PathologyData:Right_Side_Level_V Indicates the number of involved metastatic lymph nodes on the right side of level V of the neck. PathologyData:Site Anatomical localization of the tumor according to the ICD10-CM classification. PathologyData:Surgical_Margins Indicates whether cancer cells are present or not at the surgical edge of the resection specimen; it does not apply to incisional biopsies. PathologyData:TNM_pN_7Edition The TNM staging system is a system to describe the amount and spread of cancer in a patient’s body, using TNM. T describes the size of the tumor and any spread of cancer into nearby tissue; N describes spread of cancer to nearby lymph nodes; and M describes metastasis (spread of cancer to other parts of the body). This system was created and is updated by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). The TNM staging system is used to describe most types of cancer. Also called AJCC staging system. This refer to the 7th edition published in 2009 and the effective dates for cancer diagnoses are 2010-2016. PathologyData:TNM_pN_8Edition_OralCavity_Oropharynx_p16Negative_Hypopharynx_Larynx The TNM staging system is a system to describe the amount and spread of cancer in a patient’s body, using TNM. T describes the size of the tumor and any spread of cancer into nearby tissue; N describes spread of cancer to nearby lymph nodes; and M describes metastasis (spread of cancer to other parts of the body). This system was created and is updated by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). The TNM staging system is used to describe most types of cancer. Also called AJCC staging system. This refer to the 8th edition published in 2016 and the effective dates for cancer diagnoses are from 2017. This staging is for the following tumor regions: Oral Cavity, Oropharynx (p16-Negative), Hypopharynx and Larynx. PathologyData:TNM_pN_8Edition_Oropharynx_p16Positive The TNM staging system is a system to describe the amount and spread of cancer in a patient’s body, using TNM. T describes the size of the tumor and any spread of cancer into nearby tissue; N describes spread of cancer to nearby lymph nodes; and M describes metastasis (spread of cancer to other parts of the body). This system was created and is updated by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). The TNM staging system is used to describe most types of cancer. Also called AJCC staging system. This refer to the 8th edition published in 2016 and the effective dates for cancer diagnoses are from 2017. This staging is for the following tumor regions: Oropharynx (p16-Positive). PathologyData:TNM_pT_7Edition The TNM staging system is a system to describe the amount and spread of cancer in a patient’s body, using TNM. T describes the size of the tumor and any spread of cancer into nearby tissue; N describes spread of cancer to nearby lymph nodes; and M describes metastasis (spread of cancer to other parts of the body). This system was created and is updated by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). The TNM staging system is used to describe most types of cancer. Also called AJCC staging system. This refer to the 7th edition published in 2009 and the effective dates for cancer diagnoses are 2010-2016. PathologyData:TNM_pT_8Edition_OralCavity_Oropharynx_p16Negative_Hypopharynx_Larynx The TNM staging system is a system to describe the amount and spread of cancer in a patient’s body, using TNM. T describes the size of the tumor and any spread of cancer into nearby tissue; N describes spread of cancer to nearby lymph nodes; and M describes metastasis (spread of cancer to other parts of the body). This system was created and is updated by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). The TNM staging system is used to describe most types of cancer. Also called AJCC staging system. This refer to the 8th edition published in 2016 and the effective dates for cancer diagnoses are from 2017. This staging is for the following tumor regions: Oral Cavity, Oropharynx (p16-Negative), Hypopharynx and Larynx. PathologyData:TNM_pT_8Edition_Oropharynx_p16Positive The TNM staging system is a system to describe the amount and spread of cancer in a patient’s body, using TNM. T describes the size of the tumor and any spread of cancer into nearby tissue; N describes spread of cancer to nearby lymph nodes; and M describes metastasis (spread of cancer to other parts of the body). This system was created and is updated by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). The TNM staging system is used to describe most types of cancer. Also called AJCC staging system. This refer to the 8th edition published in 2016 and the effective dates for cancer diagnoses are from 2017. This staging is for the following tumor regions: Oropharynx (p16-Positive). PathologyData:Tissue_Type The type of specimen used for diagnosis based on the procedure performed to remove the tissue from the body. The possible options can be: resection specimen (wide surgical resection performed with intent of cure) and biopsy (excisional or incisional sample obtained for diagnostic purposes). PathologyData:Tumor_Depth_Invasion Describes the degree tumor depth invasion only when oral cavity cancer is diagnosed. Indicates if the tumor depth invasion is less than 5mm, between 5mm and 10mm or more than 10mm. PathologyData:Tumor_Maximum_Diameter Indicates the value in millimeters (mm) of maximum diameter of tumor. PathologyData:Tumor_Thickness The value in millimeters (mm) of tumor thickness; it includes any exophytic component. PathologyData:Type_of_Test Describes in detail the polymerase chain reaction (PCR) method used for HPV DNA or RNA detection. PathologyData:p16ink4a_stain Immunoreactivity to p16ink4a protein in tumor cells; strong stain in >70% of tumor cells correlates with the presence of cancerogenic HPV types. This applies only to oro-pharyngeal tumors. PathologyData:p53_stain Immunoreactivity to p53 protein, either diffuse overexpression or complete loss of expression correlate with mutated status. PathologyData:p53_stain_percentage Indicates the percentage of immunoreactive tumor cells on the total of tumor cells to p53 in a tissue sample. PatientSelection:Consent PatientSelection:Date_of_ICF PatientSelection:Eligibility_Criteria PopHRS:Chemotherapy PopHRS:Clinical_T_and_N_Characteristics PopHRS:Country PopHRS:Demographic_Clinical_Data PopHRS:Follow_Up PopHRS:Hospital_of_Chemotherapy PopHRS:Hospital_of_Chemotherapy_2 PopHRS:Hospital_of_Radiotherapy PopHRS:Hospital_of_Surgery PopHRS:Number_of_Info_Available_in_Patho_Report PopHRS:Number_of_Info_Available_in_Patho_Report_for_Patients_Without_Lymph_Involvement PopHRS:Pathology_Data PopHRS:Radiotherapy PopHRS:Registry PopHRS:Stage_cM PopHRS:Stage_pM PopHRS:Surgery PopHRSchemo:Chemotherapy_Treatment PopHRSchemo:Date_of_Start_Chemotherapy PopHRSclinical:Date_of_Birth PopHRSclinical:Date_of_Diagnose PopHRSclinical:Gender PopHRSclinical:Hospital_of_Diagnose PopHRSclinical:Patient_ID PopHRSclinical:Stage_Diagnosis PopHRSctn:Site PopHRSctn:Stage_cN PopHRSctn:Stage_cT PopHRSfollow:Last_Date_of_Follow_Up PopHRSfollow:Status_Patient PopHRSpatho:Morphology PopHRSpatho:Stage_pN PopHRSpatho:Stage_pT PopHRSradio:Date_of_Start_Radiotherapy PopHRSradio:Radiotherapy_Treatment PopHRSsurge:Date_of_Surgery PopHRSsurge:Surgery_Treatment PopHRSsurge:Surgery_of_Primary_Tumor_Done PopPS:Clinical_TNM_Reference PopPS:Clinical_T_and_N_Characteristics PopPS:Country PopPS:Demographic_Clinical_Data PopPS:Follow_Up PopPS:Pathological_TNM_Reference PopPS:Pathology_Data PopPS:TNM_Condensed_M PopPS:TNM_Condensed_N PopPS:TNM_Condensed_T PopPS:TNM_cM PopPS:TNM_pM PopPS:Tier1 PopPS:Tier2 PopPS:Treatment_1 PopPS:Treatment_2 PopPS:Treatment_3 PopPS:Treatment_4 PopPS:Treatment_5 PopPS:Tumor_Sequence_Number PopPSclinical:Age_at_Diagnosis PopPSclinical:Date_of_Diagnosis PopPSclinical:Hospital_Diagnosis_Geographic_Area PopPSclinical:Hospital_Diagnosis_Level_of_Specialization PopPSclinical:Hospital_of_Diagnosis PopPSclinical:Morphology PopPSclinical:Patient_ID PopPSclinical:Sex PopPSclinical:Stage PopPSclinical:Stage_cN PopPSclinical:University_Hospital_Diagnosis PopPSclinical:Year_of_Birth PopPSctn:Stage_cT PopPSctn:Topography PopPSfollow:Date_Last_Known_Vital_Status PopPSfollow:Vital_Status PopPSpatho:Grade PopPSpatho:Stage_pN PopPSpatho:Stage_pT PopPSt1:Day_of_T1 PopPSt1:Hospital_Geographic_Area_T1 PopPSt1:Hospital_Level_of_Specialization_T1 PopPSt1:Hospital_of_T1 PopPSt1:Intent_of_T1 PopPSt1:Month_of_T1 PopPSt1:Type_of_T1 PopPSt1:University_Hospital_T1 PopPSt1:Year_of_T1 PopPSt2:Day_of_T2 PopPSt2:Hospital_Geographic_Area_T2 PopPSt2:Hospital_Level_of_Specialization_T2 PopPSt2:Hospital_of_T2 PopPSt2:Intent_of_T2 PopPSt2:Month_of_T2 PopPSt2:Type_of_T2 PopPSt2:University_Hospital_T2 PopPSt2:Year_of_T2 PopPSt3:Day_of_T3 PopPSt3:Hospital_Geographic_Area_T3 PopPSt3:Hospital_Level_of_Specialization_T3 PopPSt3:Hospital_of_T3 PopPSt3:Intent_of_T3 PopPSt3:Month_of_T3 PopPSt3:Type_of_T3 PopPSt3:University_Hospital_T3 PopPSt3:Year_of_T3 PopPSt4:Day_of_T4 PopPSt4:Hospital_Geographic_Area_T4 PopPSt4:Hospital_Level_of_Specialization_T4 PopPSt4:Hospital_of_T4 PopPSt4:Intent_of_T4 PopPSt4:Month_of_T4 PopPSt4:Type_of_T4 PopPSt4:University_Hospital_T4 PopPSt4:Year_of_T4 PopPSt5:Day_of_T5 PopPSt5:Hospital_Geographic_Area_T5 PopPSt5:Hospital_Level_of_Specialization_T5 PopPSt5:Hospital_of_T5 PopPSt5:Intent_of_T5 PopPSt5:Month_of_T5 PopPSt5:Type_of_T5 PopPSt5:University_Hospital_T5 PopPSt5:Year_of_T5 QoL:Deglutition Indicates the evaluation of deglutition function. Deglutition assessment is based on the ability to swallow normally, liquid diet, semi-liquid diet, or if the patient has a gastrostomy or SNG. Swallowing-related quality of life (SWAL-QOL) scoring may be used. QoL:EORTC_QLQ_HN30 The EORTC QLQ-C30 is a questionnaire developed to assess the quality of life of cancer patients. Questionnaire to evaluate overall quality of life in terms of health, treatments and financial impact of cancer patients. Available at URL: http://groups.eortc.be/qol/sites/default/files/img/slider/specimen_qlq-c30_english.pdf QoL:EORTC_QLQ_HN35 Specific module of EORTC Quality of Life questionnaire to assess the quality of life in head and neck cancer patients, consisting of 35 questions complementing the EORTC QLQ-HN30 Questionnaire. Available at URL: http://groups.eortc.be/qol/sites/default/files/img/specimen_for_printing_hn35.pdf QoL:EuroQoL_EQ_5D Standardized instrument developed by the EuroQol Group as a measure of health-related quality of life that can be used in a wide range of health conditions and treatments. The EQ-5D consists of a descriptive system and the EQ VAS. The descriptive system comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. The EQ VAS records the patient’s self-rated health on a vertical visual analogue scale. This can be used as a quantitative measure of health outcome that reflects the patient’s own judgment. The scores on these five dimensions can be presented as a health profile or can be converted to a single summary index number (utility) reflecting preferability compared to other health profiles. Currently three versions of EQ-5D exist: EQ-5D with 3 levels of severity for each of the 5 dimensions: EQ-5D-3L EQ-5D with 5 levels of severity for each of the 5 dimensions: EQ-5D-5L EQ-5D for use in children: EQ-5D-Y QoL:Respiration Indicates the evaluation of respiration function. The breathing assessment is based on the ability to breathe normally or if the patient has a permanent tracheotomy. Radiotherapy:LR_CTV_Elective_Nodal_Volume Low Risk – Clinical Target Volume : Indicates whether (elective) lymph nodes on one side or both sides of the neck are irradiated. Radiotherapy:Note_to_ToRT Radiotherapy:Overall_Treatment_Time Total duration of radiotherapy treatment. Number of days from the first day of radiotherapy treatment until the last day of radiotherapy treatment. Radiotherapy:RT_End_Date Date when radiotherapy treatment ends. Expressed as DD/MM/YYYY. Radiotherapy:RT_Fractionation_Referred_to_dose_per_fraction_HR_CTV Indicates the dose per fraction to High Risk – Clinical Target Volume. Radiotherapy:RT_Start_Date Date when radiotherapy treatment starts. Expressed as DD/MM/YYYY. Radiotherapy:Radiotherapy_Treatment Indicates if radiotherapy treatment is performed or not. Radiotherapy:Reason_for_Discontinuation Indicates the reason for treatment (radiotherapy) termination. The termination could be when the planned treatment is finished, or when it is finished earlier, for example due to tumor progression or toxicity. Radiotherapy:Setting Indicates the configuration of the radiotherapy performed. Radiotherapy:Target_Volume_RT Radiotherapy:Time_from_Surgery_to_beginning_of_RT Indicates the number of weeks from surgery until the first day of radiotherapy. Radiotherapy:Total_Dose_HR_CTV High risk CTV represents an area around the macroscopic disease (GTV) with high risk for microscopic spread, that is treated to the same dose as the GTV. Usually 5-10mm around primary tumor or positive lymph nodes. Radiotherapy:Total_Dose_IR_CTV Indicates the total dose of radiotherapy applied in Intermediate Risk – Clinical Target Volume. Expressed in Gy. IR-CTV is optional in case a third dose level for radiotherapy is used, for example when pathologic lymph nodes or a larger area around the HR-CTV receive a lower dose than the GTV. Should be 0 if no IR-CTV is used. Radiotherapy:Total_Dose_LR_CTV LR-CTV represents an area with low risk for microscopic disease, treated with a lower dose than the GTV. For example elective nodal regions or a structure or compartment adjacent to the primary tumor. Radiotherapy:Total_Number_of_Fractions Indicates the total number of fractions applied during the radiotherapy. Radiotherapy:Total_Number_of_Fractions_to_HR_CTV Indicates the total number of fractions to High Risk – Clinical Target Volume applied during the radiotherapy. Radiotherapy:Total_Treatment_Package Indicates the total time from surgery to completion of postoperative treatment, that is the amount of days between the day of surgery and the last day of postoperative radiotherapy. Shorter treatment package time is associated with improved tumor control and survival. Radiotherapy:Type_of_RT Indicates the modality of the radiotherapy treatment. RadiomicsDataMRI:FOS_Histogram_Entropy RadiomicsDataMRI:FOS_Histogram_Kurtosis RadiomicsDataMRI:FOS_Histogram_Mad RadiomicsDataMRI:FOS_Histogram_Max RadiomicsDataMRI:FOS_Histogram_Mean RadiomicsDataMRI:FOS_Histogram_Median RadiomicsDataMRI:FOS_Histogram_Min RadiomicsDataMRI:FOS_Histogram_Quantile_0 RadiomicsDataMRI:FOS_Histogram_Quantile_0.1 RadiomicsDataMRI:FOS_Histogram_Quantile_0.2 RadiomicsDataMRI:FOS_Histogram_Quantile_0.3 RadiomicsDataMRI:FOS_Histogram_Quantile_0.4 RadiomicsDataMRI:FOS_Histogram_Quantile_0.5 RadiomicsDataMRI:FOS_Histogram_Quantile_0.6 RadiomicsDataMRI:FOS_Histogram_Quantile_0.7 RadiomicsDataMRI:FOS_Histogram_Quantile_0.8 RadiomicsDataMRI:FOS_Histogram_Quantile_0.9 RadiomicsDataMRI:FOS_Histogram_Quantile_1 RadiomicsDataMRI:FOS_Histogram_RMS RadiomicsDataMRI:FOS_Histogram_Range RadiomicsDataMRI:FOS_Histogram_STD RadiomicsDataMRI:FOS_Histogram_Skewness RadiomicsDataMRI:FOS_Histogram_TotalFrequency RadiomicsDataMRI:FOS_Histogram_Uniformity RadiomicsDataMRI:FOS_Histogram_Variance RadiomicsDataMRI:FOS_Signal_Energy RadiomicsDataMRI:FOS_Signal_Kurtosis RadiomicsDataMRI:FOS_Signal_Mad RadiomicsDataMRI:FOS_Signal_Max RadiomicsDataMRI:FOS_Signal_Mean RadiomicsDataMRI:FOS_Signal_Median RadiomicsDataMRI:FOS_Signal_Min RadiomicsDataMRI:FOS_Signal_RMS RadiomicsDataMRI:FOS_Signal_Range RadiomicsDataMRI:FOS_Signal_STD RadiomicsDataMRI:FOS_Signal_Skewness RadiomicsDataMRI:FOS_Signal_Variance RadiomicsDataMRI:GLCM_Autocorrelation RadiomicsDataMRI:GLCM_Cluster_Prominence RadiomicsDataMRI:GLCM_Cluster_Shade RadiomicsDataMRI:GLCM_Cluster_Tendency RadiomicsDataMRI:GLCM_Contrast RadiomicsDataMRI:GLCM_Correlation RadiomicsDataMRI:GLCM_Difference_Entropy RadiomicsDataMRI:GLCM_Dissimilarity RadiomicsDataMRI:GLCM_Energy RadiomicsDataMRI:GLCM_Entropy RadiomicsDataMRI:GLCM_Homogeneity RadiomicsDataMRI:GLCM_Homogeneity2 RadiomicsDataMRI:GLCM_IMOC1 RadiomicsDataMRI:GLCM_IMOC2 RadiomicsDataMRI:GLCM_Inertia RadiomicsDataMRI:GLCM_Inverse_Difference_moment RadiomicsDataMRI:GLCM_Inverse_Difference_moment2 RadiomicsDataMRI:GLCM_Inverse_Variance RadiomicsDataMRI:GLCM_Max_Probability RadiomicsDataMRI:GLCM_Sum_Average RadiomicsDataMRI:GLCM_Sum_Entropy RadiomicsDataMRI:GLRLM_Gray_Level_Non_Uniformity RadiomicsDataMRI:GLRLM_High_Gray_Level_Run_Emphasis RadiomicsDataMRI:GLRLM_Long_Run_Emphasis RadiomicsDataMRI:GLRLM_Long_Run_High_Gray_Level_Emphasis RadiomicsDataMRI:GLRLM_Long_Run_Low_Gray_Level_Emphasis RadiomicsDataMRI:GLRLM_Low_Gray_Level_Run_Emphasis RadiomicsDataMRI:GLRLM_Run_Length_Non_Uniformity RadiomicsDataMRI:GLRLM_Run_Percentage RadiomicsDataMRI:GLRLM_Short_Run_Emphasis RadiomicsDataMRI:GLRLM_Short_Run_High_Gray_Level_Emphasis RadiomicsDataMRI:GLRLM_Short_Run_Low_Gray_Level_Emphasis RadiomicsDataMRI:SS_Area RadiomicsDataMRI:SS_Compactness_1 RadiomicsDataMRI:SS_Compactness_2 RadiomicsDataMRI:SS_Equivalent_R RadiomicsDataMRI:SS_Kurtosis_3D_diameter RadiomicsDataMRI:SS_Maximum_3D_diameter RadiomicsDataMRI:SS_Mean_3D_diameter RadiomicsDataMRI:SS_Mean_Facet_Normal0 RadiomicsDataMRI:SS_Mean_Facet_Normal1 RadiomicsDataMRI:SS_Mean_Facet_Normal2 RadiomicsDataMRI:SS_Median_3D_diameter RadiomicsDataMRI:SS_Minimum_3D_diameter RadiomicsDataMRI:SS_STD_3D_diameter RadiomicsDataMRI:SS_Skewness_3D_diameter RadiomicsDataMRI:SS_Spherical_Disproportion RadiomicsDataMRI:SS_Sphericity RadiomicsDataMRI:SS_Surface_to_Volume_Ratio RadiomicsDataMRI:SS_Variance_3D_diameter RadiomicsDataMRI:SS_Volume RiskFactors:Additional_precancerous_lesion_1 A premalignant pathologic process that affects the anatomic structures of the head and neck. Representative examples include oral leukoplakia and leukoplakia of the vocal cords. RiskFactors:Additional_precancerous_lesion_2 A premalignant pathologic process that affects the anatomic structures of the head and neck. Representative examples include oral leukoplakia and leukoplakia of the vocal cords. RiskFactors:Family_History_of_Malignancies A clinical history in which there is a diagnosis of cancer in a blood relative. RiskFactors:History_of_Alcohol_Dependence Alcohol dependence is a chronic disease in which a person craves drinks that contain alcohol and is unable to control his or her drinking. A person with this disease also needs to drink greater amounts to get the same effect and has withdrawal symptoms after stopping alcohol use. Alcohol dependence affects physical and mental health, and can cause problems with family, friends, and work. Regular heavy alcohol intake increases the risk of several types of cancer. Also called alcoholism. RiskFactors:Location_of_additional_precancerous_lesion_1 Location of the additional precancerous lesion based on the ICD-10 code. RiskFactors:Location_of_additional_precancerous_lesion_2 Location of the additional precancerous lesion based on the ICD-10 code. RiskFactors:Notes_risk Additional notes for Risk section. RiskFactors:Number_of_Alcohol_Units_per_Day Number of alcohol units consumed in 1 day based on the unit calculator (https://www.alcoholconcern.org.uk/unit-calculator) Type of drink ---------- Number of alcohol units Standard glass of wine ---------- 2.3 units Small Glass of Wine ---------- 1.3 units Large glass of wine ---------- 3.3 units Pint of strong lager or ale ---------- 3.0 units Alcopop ---------- 1.4 units Shot of whiskey ---------- 1.0 units Pint of lager ---------- 2.0 units Bottle of super strength lager or ale ---------- 3.0 units Can of super strength lager or ale ---------- 3.5 units RiskFactors:Oral_Hygiene The practice of keeping the mouth, teeth, and gums clean and healthy to prevent disease, as by regular brushing and flossing and visits to a dentist. RiskFactors:Pack_Years A way to measure the amount a person has smoked over a long period of time. It is calculated by multiplying the number of packs of cigarettes smoked per day by the number of years the person has smoked. For example, 1 pack year is equal to smoking 1 pack (20 cigarettes) per day for 1 year, or 2 packs per day for half a year, and so on. Number of pack-years = (packs smoked per day) × (years as a smoker) or Number of pack-years = (number of cigarettes smoked per day/20) × number of years smoked. (1 pack has 20 cigarettes in some countries) RiskFactors:Packs_Smoked_per_Day Number of packs of cigarettes or cigars consumed in 1 day. 1pack = numbers per Day/20 per cigarettes or /4 per cigars RiskFactors:Risk_Factors RiskFactors:Smoker_at_Time_of_Diagnosis An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history. RiskFactors:Smoking_Habits Indicates any of the habits associated with smoking. RiskFactors:Years_as_a_Smoker Number of total years an individual smoked or currently smokes cigarettes. This drink is equivalent to 1.4 units of alcohol. Alcopop This drink is equivalent to 3.0 units of alcohol. Bottle_Super_Strength_Lager This drink is equivalent to 3.5 units of alcohol. Can_Super_Strength_Lager This drink is equivalent to 3.3 units of alcohol. Lar_Wine This drink is equivalent to 2.0 units of alcohol. Pint_Lager This drink is equivalent to 3.0 units of alcohol. Pint_Strong_Lager This drink is equivalent to 1.3 units of alcohol. Sm_Wine This drink is equivalent to 2.3 units of alcohol. Std_Wine This drink is equivalent to 1.0 units of alcohol. Whiskey Surgery:Complication A response that indicates whether a complication occurred during or after surgery. Surgery:Complication_Action_Taken A response that indicates different actions that can be addressed after complication. Surgery:Date_of_Resolution Date on which the problem of the complication is resolved. Expressed as DD/MM/YYYY. Surgery:Date_of_Surgery Date when patient was intervened with a surgical procedure. Expressed as DD/MM/YYYY. Surgery:Hospitalization_End_Date Date when patient was discharged from the hospital after a surgical procedure. Expressed as DD/MM/YYYY. Surgery:Hospitalization_Start_Date Date when patient was admitted to the hospital for a surgical procedure. Expressed as DD/MM/YYYY. Surgery:Kind_of_Left_Neck_Dissection Kind of neck dissection performed in the left side. Surgery:Kind_of_Right_Neck_Dissection Kind of neck dissection performed in the right side. Surgery:Method_of_Surgery Type of surgical procedure taking into account the method implemented. Surgery:Neck_Dissection Surgery to remove lymph nodes and other tissues in the neck. Surgery:Note_PoC_MbC Description how the original plan of care was modified because of the complication. Expressed in a text note. Surgery:Plan_of_Care_Modified_by_Complication A response that indicates whether the plan of care was modified due to complication. Surgery:Site_Neck_Dissection Position of the neck where the dissection is performed. It could be in the right side, left side or both (bilateral). Surgery:Site_of_Surgery Position of the body where the surgery is performed. It could be the right or left side or in the midline. Surgery:Surgery_Reason A response indicating the surgery’s aim, which could be a primary tumor or a recurrent tumor. Surgery:Surgical_Reconstruction Surgery that is done to reshape or rebuild (reconstruct) a part of the body changed by previous surgery. Surgery:Tracheostomy Surgery to create an opening (stoma) into the windpipe. The opening itself may also be called a tracheostomy. Surgery:Type_of_Complication A response that indicates specific complication occurred during or after surgery. Surgery:Type_of_Surgery Type of surgery dependent on the involved structure in the head and neck region. The removed structure of the head and neck region is defined by the name of the performed surgery. Surgery:Undergone_Cancer_Surgery A response indicating that an individual has been operated or not due to head and neck cancer. Toxicity:Aspiration_Toxicity_12 A disorder characterized by inhalation of solids or liquids into the lungs. G3: Dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally G4: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated G5: Death Toxicity:Aspiration_Toxicity_24 A disorder characterized by inhalation of solids or liquids into the lungs. G3: Dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally G4: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated G5: Death Toxicity:Aspiration_Toxicity_6 A disorder characterized by inhalation of solids or liquids into the lungs. G3: Dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally G4: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated G5: Death Toxicity:Asthenia_Toxicity_12 CTCAE: Fatigue. G1: Fatigue relieved by rest G2: Fatigue not relieved by rest; limiting instrumental ADL G3: Fatigue not relieved by rest, limiting self care ADL G4-G5: Not reported Toxicity:Asthenia_Toxicity_24 CTCAE: Fatigue. G1: Fatigue relieved by rest G2: Fatigue not relieved by rest; limiting instrumental ADL G3: Fatigue not relieved by rest, limiting self care ADL G4-G5: Not reported Toxicity:Asthenia_Toxicity_6 CTCAE: Fatigue. G1: Fatigue relieved by rest G2: Fatigue not relieved by rest; limiting instrumental ADL G3: Fatigue not relieved by rest, limiting self care ADL G4-G5: Not reported Toxicity:Date_of_Compilation_12 Date when the information regarding the toxicity at 12 months was collected. Toxicity:Date_of_Compilation_24 Date when the information regarding the toxicity at 24 months was collected. Toxicity:Date_of_Compilation_6 Date when the information regarding the toxicity at 6 months was collected. Toxicity:Date_of_Compilation_AcTox Date when the toxicity information was collected. Toxicity:Dysphagia_AcTox A disorder characterized by difficulty in swallowing. G3: Severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Dysphagia_Toxicity_12 A disorder characterized by difficulty in swallowing. G3: Severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Dysphagia_Toxicity_24 A disorder characterized by difficulty in swallowing. G3: Severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Dysphagia_Toxicity_6 A disorder characterized by difficulty in swallowing. G3: Severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Dyspnea_Toxicity_12 A disorder characterized by an uncomfortable sensation of difficulty breathing. G3: Shortness of breath at rest; limiting self care ADL G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Dyspnea_Toxicity_24 A disorder characterized by an uncomfortable sensation of difficulty breathing. G3: Shortness of breath at rest; limiting self care ADL G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Dyspnea_Toxicity_6 A disorder characterized by an uncomfortable sensation of difficulty breathing. G3: Shortness of breath at rest; limiting self care ADL G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Gastrostomy_Toxicity_12 Is the creation of an artificial external opening into the stomach for nutritional support or gastric decompression. (ICD-10-CM: Z93.1) Toxicity:Gastrostomy_Toxicity_24 Is the creation of an artificial external opening into the stomach for nutritional support or gastric decompression. (ICD-10-CM: Z93.1) Toxicity:Gastrostomy_Toxicity_6 Is the creation of an artificial external opening into the stomach for nutritional support or gastric decompression. (ICD-10-CM: Z93.1) Toxicity:Hepatic_AcTox Presence of at least one of these CTCAE definitions: 1.Alanine aminotransferase increased G1: >ULN - 3.0 x ULN G2: >3.0 - 5.0 x ULN G3: >5.0 - 20.0 x ULN G4: >20.0 x ULN G5: not reported 2.Alkaline phosphatase increased G1: >ULN - 2.5 x ULN G2: >2.5 - 5.0 x ULN G3: >5.0 - 20.0 x ULN G4: >20.0 x ULN G5: Not reported 3.Aspartate aminotransferase increased G1: >ULN - 3.0 x ULN G2: >3.0 - 5.0 x ULN G3: >5.0 - 20.0 x ULN G4: >20.0 x ULN G5: Not reported 4.Blood bilirubin increased G1: >ULN - 1.5 x ULN G2: >1.5 - 3.0 x ULN G3: >3.0 - 10.0 x ULN G4: >10.0 x ULN G5: Not reported 5.GGT increased G1: >ULN - 2.5 x ULN G2: >2.5 - 5.0 x ULN G3: >5.0 - 20.0 x ULN G4: >20.0 x ULN G5: Not reported Toxicity:Infection_AcTox A disorder characterized by an inflammatory or infectious process involving the larynx, lips, lymph nodes, trachea, salivary glands, etc. G3: IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Medullary_AcTox Presence of at least one of these CTCAE definitions: 1.White blood cell decreased G1: <LLN - 3000/mm3; <LLN - 3.0 x 10^9 /L G2: <3000 - 2000/mm3; <3.0 - 2.0 x 10^9 /L G3: <2000 - 1000/mm3; <2.0 - 1.0 x 10^9 /L G4: <1000/mm3; <1.0 x 10^9 /L G5: Not reported 2.Neutrophil count decreased G1: <LLN - 1500/mm3; <LLN - 1.5 x 10^9 /L G2: <1500 - 1000/mm3; <1.5 - 1.0 x 10^9 /L G3: <1000 - 500/mm3; <1.0 - 0.5 x 10^9 /L G4: <500/mm3; <0.5 x 10^9 /L G5: Not reported 3.Platelet count decreased G1: <LLN - 75,000/mm3; <LLN - 75.0 x 10^9 /L G2: <75,000 - 50,000/mm3; <75.0 - 50.0 x 10^9 /L G3: <50,000 - 25,000/mm3; <50.0 - 25.0 x 10^9 /L G4: <25,000/mm3; <25.0 x 10^9/L G5: Not reported 4.Anemia G1: Hemoglobin (Hgb) <LLN - 10.0 g/dL; <LLN - 6.2 mmol/L; <LLN - 100 g/L G2: Hgb <10.0 - 8.0 g/dL; <6.2 - 4.9 mmol/L; <100 - 80g/L G3: Hgb <8.0 g/dL; <4.9 mmol/L; <80 g/L; transfusion indicated G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Mucositis_AcTox Oral: A disorder characterized by inflammation of the oral mucosal. G3: Severe pain; interfering with oral intake G4: Life-threatening consequences; urgent intervention indicated G5: Death Laryngeal: A disorder characterized by an inflammation involving the mucous membrane of the larynx G3: Severe pain; severely altered eating/swallowing; medical intervention indicated G4: Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) G5: Death Pharyngeal: A disorder characterized by an inflammation involving the mucous membrane of the pharynx. G3: Severe pain; unable to adequately aliment or hydrate orally; limiting self-care ADL G4: Life-threatening consequences; urgent intervention indicated G5: Death Tracheal: A disorder characterized by an inflammation involving the mucous membrane of the trachea. G3: Severe pain; hemorrhage or respiratory symptoms; limiting self-care ADL G4: Life-threatening consequences; urgent intervention indicated G5: Death Toxicity:Pain_Toxicity_12 A disorder characterized by the sensation of distress, agony or marked discomfort in a lymph node, mouth, tongue or lips. G3: Severe pain; limiting self care ADL (Activities of Daily Living) G4: Grade not available G5: Grade not available Toxicity:Pain_Toxicity_24 A disorder characterized by the sensation of distress, agony or marked discomfort in a lymph node, mouth, tongue or lips. G3: Severe pain; limiting self care ADL (Activities of Daily Living) G4: Grade not available G5: Grade not available Toxicity:Pain_Toxicity_6 A disorder characterized by the sensation of distress, agony or marked discomfort in a lymph node, mouth, tongue or lips. G3: Severe pain; limiting self care ADL (Activities of Daily Living) G4: Grade not available G5: Grade not available Toxicity:Renal_AcTox CTCAE: Acute kidney injury. G1: Creatinine level increase of >0.3 mg/dL; creatinine 1.5 - 2.0 x above baseline G2: Creatinine 2 - 3 x above baseline G3: Creatinine >3 x baseline or >4.0 mg/dL; hospitalization indicated G4: Life-threatening consequences; dialysis indicated G5: Death Toxicity:Toxicity_Availability_12 Availability of the information regarding the patient toxicity at 12 months after treatment end. Toxicity:Toxicity_Availability_24 Availability of the information regarding the patient toxicity at 24 months after treatment end. Toxicity:Toxicity_Availability_6 Availability of the information regarding the patient toxicity at 6 months after treatment end. Toxicity:Tracheotomy_Toxicity_12 A surgical procedure which consists of making an incision on the anterior aspect of the neck and opening a direct airway through an incision in the trachea. (ICD-10-PCS: 0B110F4) Toxicity:Tracheotomy_Toxicity_24 A surgical procedure which consists of making an incision on the anterior aspect of the neck and opening a direct airway through an incision in the trachea. (ICD-10-PCS: 0B110F4) Toxicity:Tracheotomy_Toxicity_6 A surgical procedure which consists of making an incision on the anterior aspect of the neck and opening a direct airway through an incision in the trachea. (ICD-10-PCS: 0B110F4) Toxicity:Trismus_Toxicity_12 A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication. G3: Decreased ROM with inability to adequately aliment or hydrate orally G4: Grade not available G5: Grade not available Toxicity:Trismus_Toxicity_24 A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication. G3: Decreased ROM with inability to adequately aliment or hydrate orally G4: Grade not available G5: Grade not available Toxicity:Trismus_Toxicity_6 A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication. G3: Decreased ROM with inability to adequately aliment or hydrate orally G4: Grade not available G5: Grade not available Toxicity:Xerostomia_AcTox CTCAE: Dry mouth. G1: Symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min G2: Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min G3: Inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min G4-G5: Not reported Toxicity:Xerostomia_Toxicity_12 CTCAE: Dry mouth. G1: Symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min G2: Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min G3: Inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min G4-G5: Not reported Toxicity:Xerostomia_Toxicity_24 CTCAE: Dry mouth. G1: Symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min G2: Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min G3: Inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min G4-G5: Not reported Toxicity:Xerostomia_Toxicity_6 CTCAE: Dry mouth. G1: Symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min G2: Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min G3: Inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min G4-G5: Not reported BFO:0000141 IAO:0000027 IAO:0000178 IAO:0000300 IAO:0000310 IAO:0000314 Ontology1325521724189:Clinical_Trial_Study Erythroplakia Blanca Baselga 12/07/2019 The performance of this model is significantly better than the predictive value of the TNMclassification alone, but still need additional data before being used in clinical practice. ctn_TNM_cN_7Edition, risk_Pack_Years Clara Beltrán 08/07/2019 Among smokers, patients with ≤ 15 pack year history of smoking had a longer median survival than patients who had smoked > 15 pack years. As the number of pack years increased, the median overall survival decreased. risk_Pack_Years Complete response Partial response Stable disease Progression Non-evaluable Carboplatin Cetuximab Cisplatin Docetaxel 5-fluorouracil Paclitaxel Other Unknown No Yes Completed Treatment Treatment complication/Adverse Event/Adverse Drug Reaction Progression Physician decision Death Other Not specified Completed Treatment Treatment complication/Adverse Event/Adverse Drug Reaction Progression Physician decision Death Other Not specified Completed Treatment Treatment complication/Adverse Event/Adverse Drug Reaction Progression Physician decision Death Other Not specified Daily Weekly Every 21 days Every 28 days Other Daily Weekly Every 21 days Every 28 days Other Daily Weekly Every 21 days Every 28 days Other Chemotherapy strategy in which drugs are administered before a loco-regional treatment (either surgery or radiotherapy or chemo-radiotherapy). Administered before a loco-regional treatment (either surgery or radiotherapy or chemo-radiotherapy) Induction Chemotherapy strategy in which drugs are administered with radiotherapy. Administered with radiotherapy Concomitant Chemotherapy strategy in which drugs are administered after a loco-regional treatment (either surgery or radiotherapy or chemo-radiotherapy). Administered after a loco-regional treatment (either surgery or radiotherapy or chemo-radiotherapy) Adjuvant ASA category that includes normal healthy patients. Normal healthy patient I ASA category that includes patients with mild systemic disease. Patient with mild systemic disease II ASA category that includes patients with severe systemic disease. Patient with severe systemic disease III ASA category that includes patients with severe systemic disease that is a constant threat to life. Patient with severe systemic disease that is a constant threat to life IV ASA category that includes moribund patients who are not expected to survive without the operation. Moribund patient who is not expected to survive without the operation V Not Available Grade of the ECOG Performance Status that indicates that the patient is fully active and able to carry on all pre-disease performance without restriction. Fully active, able to carry on all pre-disease performance without restriction 0 Grade of the ECOG Performance Status that indicates that the patient is restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g, light house work, office work. Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work 1 Grade of the ECOG Performance Status that indicates that the patient is ambulatory and capable of all selfcare but unable to carry out any work activities and that he/she is up and about more than 50% of waking hours. Ambulatory and capable of all selfcare but unable to carry out any work activities; up and about more than 50% of waking hours 2 Grade of the ECOG Performance Status that indicates that the patient is capable of only limited selfcare and confined to bed or chair more than 50% of waking hours. Capable of only limited selfcare; confined to bed or chair more than 50% of waking hours 3 Grade of the ECOG Performance Status that indicates that the patient is completely disabled, totally confined to bed or chair and cannot carry on any selfcare. Completely disabled; cannot carry on any selfcare; totally confined to bed or chair 4 Grade of the ECOG Performance Status that indicates that the patient is dead. Dead 5 White Black or African Asian Other Not applicable for local regulations g/dL mmol/L Seropositive AIDS Negative Unknown AOP VUMC INT UDUS MAASTRO ULM GECCP MUV OTHER 10^3/µL 10^9/L 10^3/µL 10^9/L Comorbidity score according to ACE-27 that categorizes comorbid conditions of the patient as "none". None 0 Comorbidity score according to ACE-27 that categorizes comorbid conditions of the patient as "mild". Mild 1 Comorbidity score according to ACE-27 that categorizes comorbid conditions of the patient as "moderate". Moderate 2 Comorbidity score according to ACE-27 that categorizes comorbid conditions of the patient as "severe". Severe 3 Comorbidity score according to ACE-27 that categorizes comorbid conditions of the patient as "unknown". Unknown 9 10^3/µL 10^9/L Male Female Score of the Zubrod performance status that indicates that the patient is fully active, unrestricted by disease. Fully active, unrestricted by disease 0 Score of the Zubrod performance status that indicates that the patient is able to carry out light work. Able to carry out light work 1 Score of the Zubrod performance status that indicates that the patient is ambulatory but resting for as much as 50% of the day. Ambulatory but resting for as much as 50% of the day 2 Score of the Zubrod performance status that indicates that the patient is resting in bed or chair for more than half the day. Resting in bed or a chair for more than half the day 3 Score of the Zubrod performance status that indicates that the patient is confined to bed at all times. Confined to bed at all times 4 Score of the Zubrod performance status that indicates that the patient has died. Patient has died 5 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip. Malignant neoplasm of lip C00 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified. Malignant neoplasm of lip, unspecified C00.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of base of tongue. Malignant neoplasm of base of tongue C01 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of tongue. Malignant neoplasm of other and unspecified parts of tongue C02 ICD-10 code used to specify a diagnosis of malignant neoplasm of dorsal surface of tongue. Malignant neoplasm of dorsal surface of tongue C02.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of border of tongue. Malignant neoplasm of border of tongue C02.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of ventral surface of tongue. Malignant neoplasm of ventral surface of tongue C02.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior two-thirds of tongue, part unspecified. Malignant neoplasm of anterior two-thirds of tongue, part unspecified C02.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of lingual tonsil. Malignant neoplasm of lingual tonsil C02.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tongue. Malignant neoplasm of overlapping sites of tongue C02.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tongue, unspecified. Malignant neoplasm of tongue, unspecified C02.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of external upper lip. Malignant neoplasm of external upper lip C00.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum. Malignant neoplasm of gum C03 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper gum. Malignant neoplasm of upper gum C03.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower gum. Malignant neoplasm of lower gum C03.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum, unspecified. Malignant neoplasm of gum, unspecified C03.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth. Malignant neoplasm of floor of mouth C04 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior floor of mouth. Malignant neoplasm of anterior floor of mouth C04.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral floor of mouth. Malignant neoplasm of lateral floor of mouth C04.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of floor of mouth. Malignant neoplasm of overlapping sites of floor of mouth C04.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth, unspecified. Malignant neoplasm of floor of mouth, unspecified C04.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate. Malignant neoplasm of palate C05 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lower lip. Malignant neoplasm of external lower lip C00.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of hard palate. Malignant neoplasm of hard palate C05.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of soft palate. Malignant neoplasm of soft palate C05.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of uvula. Malignant neoplasm of uvula C05.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of palate. Malignant neoplasm of overlapping sites of palate C05.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate, unspecified. Malignant neoplasm of palate, unspecified C05.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of mouth. Malignant neoplasm of other and unspecified parts of mouth C06 ICD-10 code used to specify a diagnosis of malignant neoplasm of cheek mucosa. Malignant neoplasm of cheek mucosa C06.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of vestibule of mouth. Malignant neoplasm of vestibule of mouth C06.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of retromolar area. Malignant neoplasm of retromolar area C06.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of parotid gland. Malignant neoplasm of parotid gland C07 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lip, unspecified. Malignant neoplasm of external lip, unspecified C00.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified major salivary glands. Malignant neoplasm of other and unspecified major salivary glands C08 ICD-10 code used to specify a diagnosis of malignant neoplasm of submandibular gland. Malignant neoplasm of submandibular gland C08.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of sublingual gland. Malignant neoplasm of sublingual gland C08.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of major salivary gland, unspecified. Malignant neoplasm of major salivary gland, unspecified C08.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil. Malignant neoplasm of tonsil C09 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar fossa. Malignant neoplasm of tonsillar fossa C09.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar pillar (anterior) (posterior). Malignant neoplasm of tonsillar pillar (anterior) (posterior) C09.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tonsil. Malignant neoplasm of overlapping sites of tonsil C09.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil, unspecified. Malignant neoplasm of tonsil, unspecified C09.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx. Malignant neoplasm of oropharynx C10 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper lip, inner aspect. Malignant neoplasm of upper lip, inner aspect C00.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of vallecula. Malignant neoplasm of vallecula C10.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior surface of epiglottis. Malignant neoplasm of anterior surface of epiglottis C10.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of oropharynx. Malignant neoplasm of lateral wall of oropharynx C10.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of oropharynx. Malignant neoplasm of posterior wall of oropharynx C10.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of branchial cleft. Malignant neoplasm of branchial cleft C10.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of oropharynx. Malignant neoplasm of overlapping sites of oropharynx C10.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx, unspecified. Malignant neoplasm of oropharynx, unspecified C10.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx. Malignant neoplasm of nasopharynx C11 ICD-10 code used to specify a diagnosis of malignant neoplasm of superior wall of nasopharynx. Malignant neoplasm of superior wall of nasopharynx C11.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of nasopharynx. Malignant neoplasm of posterior wall of nasopharynx C11.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower lip, inner aspect. Malignant neoplasm of lower lip, inner aspect C00.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of nasopharynx. Malignant neoplasm of lateral wall of nasopharynx C11.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior wall of nasopharynx. Malignant neoplasm of anterior wall of nasopharynx C11.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of nasopharynx. Malignant neoplasm of overlapping sites of nasopharynx C11.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx, unspecified. Malignant neoplasm of nasopharynx, unspecified C11.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of pyriform sinus. Malignant neoplasm of pyriform sinus C12 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx. Malignant neoplasm of hypopharynx C13 ICD-10 code used to specify a diagnosis of malignant neoplasm of postcricoid region. Malignant neoplasm of postcricoid region C13.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect. Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect C13.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of hypopharynx. Malignant neoplasm of posterior wall of hypopharynx C13.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of hypopharynx. Malignant neoplasm of overlapping sites of hypopharynx C13.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified, inner aspect. Malignant neoplasm of lip, unspecified, inner aspect C00.5 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx, unspecified. Malignant neoplasm of hypopharynx, unspecified C13.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx. Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx C14 ICD-10 code used to specify a diagnosis of malignant neoplasm of pharynx, unspecified. Malignant neoplasm of pharynx, unspecified C14.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of Waldeyer's ring. Malignant neoplasm of Waldeyer's ring C14.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip, oral cavity and pharynx. Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx C14.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx. Malignant neoplasm of larynx C32 ICD-10 code used to specify a diagnosis of malignant neoplasm of glottis. Malignant neoplasm of glottis C32.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of supraglottis. Malignant neoplasm of supraglottis C32.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of subglottis. Malignant neoplasm of subglottis C32.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of laryngeal cartilage. Malignant neoplasm of laryngeal cartilage C32.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of commissure of lip, unspecified. Malignant neoplasm of commissure of lip, unspecified C00.6 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of larynx. Malignant neoplasm of overlapping sites of larynx C32.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx, unspecified. Malignant neoplasm of larynx, unspecified C32.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip. Malignant neoplasm of overlapping sites of lip C00.8 Depth range for tumour invasion corresponding to less invasive lesions. It matches with T1 in the TNM classification system. Indicates less invasive lesion (T1) ≤5mm Depth range for tumour invasion corresponding to moderate depth of invasion cancer. It matches with T2 in the TNM classification system. Indicates moderate depth (T2) >5mm and ≤10mm Depth range for tumour invasion corresponding to deeply invasive cancers. It matches with T3 in the TNM classification system. Indicates deeply invasive cancers (T3) >10mm Yes No Left Right Midline Ipsilateral Contralateral Bilateral IA IB IIA IIB III IV VA VB VI IA IB IIA IIB III IV VA VB VI Stage 0 Stage I Stage II Stage III Stage IVA Stage IVB Stage IVC Stage 0 Stage I Stage II Stage III Stage IVA Stage IVB Stage IVC Stage 0 Stage I Stage II Stage III Stage IV Yes No NX N0 N1 N2a N2b N2c N3 NX N0 N1 N2a N2b N2c N3a N3b NX N0 Alphanumeric code of the TNM classification system (8th Edition) which in this case indicates that the oropharynx cancer (p16-Positive) has spread to one or more ipsilateral lymph nodes, none larger than 6 cm. One or more ipsilateral lymph nodes, none larger than 6 cm N1 Alphanumeric code of the TNM classification system (8th Edition) which in this case indicates that the oropharynx cancer (p16-Positive) has spread to contralateral or bilateral lymph nodes, none larger than 6 cm. Contralateral or bilateral lymph nodes, none larger than 6 cm N2 Alphanumeric code of the TNM classification system (8th Edition) which in this case indicates that the oropharynx cancer (p16-Positive) has spread to one or more lymph nodes, none larger than 6 cm. Lymph node(s), larger than 6 cm N3 T1 T2 T3 T4a T4b T1 T2 T3 T4a T4b T1 T2 T3 T4 Presence Yes Absence No Skin Muscle Cranial nerve XI Brachial plexus Parotid gland The part of the throat at the back of the mouth behind the oral cavity. It includes the back third of the tongue, the soft palate, the side and back walls of the throat, and the tonsils. Oropharynx The area of the throat containing the vocal cords and used for breathing, swallowing, and talking. Also called voice box. Larynx Malignant disease under study: a disease in which abnormal cells divide without control and can invade nearby tissues. In our case head and neck cancer. Complication due to malignant disease under study: medical problem that occurs during a disease, or after a procedure or treatment (in our case head and neck cancer). The complication may be caused by the disease, procedure, or treatment or may be unrelated to them. Malignant disease under study, or complication due to malignant disease under study Second primary malignant disease: a new primary cancer that occurs in a person who has had cancer in the past. Second primary cancers may occur months or years after the original (primary) cancer was diagnosed and treated. Certain types of cancer treatment, such as chemotherapy and radiation therapy, may increase the risk of a second primary cancer. Having certain inherited gene mutations (changes) and being exposed to certain cancer-causing substances, such as tobacco smoke, may also increase the risk of a second primary cancer. Complication due to second primary malignant disease: medical problem that occurs during a second primary cancer, or after a procedure or treatment (in our case second primary head and neck cancer). The complication may be caused by the disease, procedure, or treatment or may be unrelated to them. Second primary malignant disease, or complication due to second primary malignant disease An unexpected medical problem that happens during treatment with a drug or other therapy. Adverse events may be mild, moderate, or severe, and may be caused by something other than the drug or therapy being given. Also called adverse effect. Adverse event (not otherwise specified) Other cause Unknown cause (not assessable or insufficient data) No Yes Dead Alive Surgery to remove all malignant (cancerous) tissue, which is meant to cure the disease. This includes removing part or all of the cancerous organ or tissue and a small amount of healthy tissue around it. Nearby lymph nodes may also be removed. Curative surgery works best for localized cancer. Chemotherapy or radiation therapy may be given before surgery to shrink the tumor or after surgery to kill any cancer cells that remain. Curative Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed) Ref. MeSH browser: https://meshb.nlm.nih.gov/record/ui?ui=D010166 Palliative A procedure to remove or repair a part of the body or to find out whether disease is present. An operation. Surgery Radiotherapy: the use of ionizing radiation to treat malignant neoplasms and some benign conditions. REF MeSH Browser https://meshb.nlm.nih.gov/record/ui?ui=D011878 RT Chemoradiotherapy: treatment that combines chemotherapy with radiotherapy. REF MeSH browser https://meshb.nlm.nih.gov/record/ui?ui=D059248 CRT Chemotherapy Adjuvant: drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment. REF. MeSH browser: https://meshb.nlm.nih.gov/record/ui?ui=D017024 CT A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis, or treatment of a disease. Also called clinical trial. Clinical study Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection. REF. MeSH Browser: https://meshb.nlm.nih.gov/record/ui?ui=D007167 Immunotherapy Other No treatment An invasive malignant cancer confined entirely to the organ where the cancer began. Local Refers to cancer that has grown beyond the original (primary) tumor to nearby lymph nodes or organs and tissues. Regional Cancer that has recurred (come back) at or near the same place as the original (primary) tumor, usually after a period of time during which the cancer could not be detected. An invasive malignant cancer confined entirely to the organ where the cancer began. Locoregional Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. Second primary tumor Refers to cancer that has spread from the original (primary) tumor to distant organs or distant lymph nodes. Also known as distant cancer. Distant metastasis Delayed lymph node metastasis When the tumor has not invaded the buccal fat. The tumor has not invaded the buccal fat Absent When there is no certainty that the tumor has invaded the buccal fat. There is no certainty that the tumor has invaded the buccal fat Probable When the tumor has invaded the buccal fat. The tumor has invaded the buccal fat Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not infiltrated the carotid. The tumor has not infiltrated the carotid Absent When there is no certainty that the tumor has infiltrated the carotid. There is no certainty that the tumor has infiltrated the carotid Probable When the tumor has infiltrated the carotid. When the tumor has infiltrated the carotid Present When it is not possible to give an answer. It is not possible to give an answer Not assessable Absent Present The tumor has not invaded the skin When the tumor has not invaded the skin. Absent When there is no certainty that the tumor has invaded the skin. There is no certainty that the tumor has invaded the skin Probable When the tumor has invaded the skin. The tumor has invaded the skin Present It is not possible to give an answer When it is not possible to give an answer. Not assessable When the tumor from lymph node has not invaded the skin. The tumor from lymph node has not invaded the skin Absent When there is no certainty that the tumor from lymph node has invaded the skin. There is no certainty that the tumor from lymph node has invaded the skin Probable When the tumor from lymph node has invaded the skin. The tumor from lymph node has invaded the skin Present When it is not possible to give an answer. It is not possible to give an answer Not assessable Absent Present ICD-10 code used to specify a diagnosis of malignant neoplasm of lip. Malignant neoplasm of lip C00 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified. Malignant neoplasm of lip, unspecified C00.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of base of tongue. Malignant neoplasm of base of tongue C01 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of tongue. Malignant neoplasm of other and unspecified parts of tongue C02 ICD-10 code used to specify a diagnosis of malignant neoplasm of dorsal surface of tongue. Malignant neoplasm of dorsal surface of tongue C02.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of border of tongue. Malignant neoplasm of border of tongue C02.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of ventral surface of tongue. Malignant neoplasm of ventral surface of tongue C02.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior two-thirds of tongue, part unspecified. Malignant neoplasm of anterior two-thirds of tongue, part unspecified C02.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of lingual tonsil. Malignant neoplasm of lingual tonsil C02.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tongue. Malignant neoplasm of overlapping sites of tongue C02.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tongue, unspecified. Malignant neoplasm of tongue, unspecified C02.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper lip. Malignant neoplasm of external upper lip C00.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum. Malignant neoplasm of gum C03 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper gum. Malignant neoplasm of upper gum C03.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower gum. Malignant neoplasm of lower gum C03.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum, unspecified. Malignant neoplasm of gum, unspecified C03.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth. Malignant neoplasm of floor of mouth C04 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior floor of mouth. Malignant neoplasm of anterior floor of mouth C04.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral floor of mouth. Malignant neoplasm of lateral floor of mouth C04.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of floor of mouth. Malignant neoplasm of overlapping sites of floor of mouth C04.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth, unspecified. Malignant neoplasm of floor of mouth, unspecified C04.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate. Malignant neoplasm of palate C05 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lower lip. Malignant neoplasm of external lower lip C00.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of hard palate. Malignant neoplasm of hard palate C05.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of soft palate. Malignant neoplasm of soft palate C05.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of uvula. Malignant neoplasm of uvula C05.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of palate. Malignant neoplasm of overlapping sites of palate C05.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate, unspecified. Malignant neoplasm of palate, unspecified C05.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of mouth. Malignant neoplasm of other and unspecified parts of mouth C06 ICD-10 code used to specify a diagnosis of malignant neoplasm of cheek mucosa. Malignant neoplasm of cheek mucosa C06.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of vestibule of mouth. Malignant neoplasm of vestibule of mouth C06.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of retromolar area. Malignant neoplasm of retromolar area C06.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of parotid gland. Malignant neoplasm of parotid gland C07 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lip, unspecified. Malignant neoplasm of external lip, unspecified C00.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified major salivary glands. Malignant neoplasm of other and unspecified major salivary glands C08 ICD-10 code used to specify a diagnosis of malignant neoplasm of submandibular gland. Malignant neoplasm of submandibular gland C08.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of sublingual gland. Malignant neoplasm of sublingual gland C08.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of major salivary gland, unspecified. Malignant neoplasm of major salivary gland, unspecified C08.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil. Malignant neoplasm of tonsil C09 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar fossa. Malignant neoplasm of tonsillar fossa C09.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar pillar (anterior) (posterior). Malignant neoplasm of tonsillar pillar (anterior) (posterior) C09.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tonsil. Malignant neoplasm of overlapping sites of tonsil C09.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil, unspecified. Malignant neoplasm of tonsil, unspecified C09.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx. Malignant neoplasm of oropharynx C10 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper lip, inner aspect. Malignant neoplasm of upper lip, inner aspect C00.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of vallecula. Malignant neoplasm of vallecula C10.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior surface of epiglottis. Malignant neoplasm of anterior surface of epiglottis C10.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of oropharynx. Malignant neoplasm of lateral wall of oropharynx C10.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of oropharynx. Malignant neoplasm of posterior wall of oropharynx C10.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of branchial cleft. Malignant neoplasm of branchial cleft C10.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of oropharynx. Malignant neoplasm of overlapping sites of oropharynx C10.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx, unspecified. Malignant neoplasm of oropharynx, unspecified C10.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx. Malignant neoplasm of nasopharynx C11 ICD-10 code used to specify a diagnosis of malignant neoplasm of superior wall of nasopharynx. Malignant neoplasm of superior wall of nasopharynx C11.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of nasopharynx. Malignant neoplasm of posterior wall of nasopharynx C11.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower lip, inner aspect. Malignant neoplasm of lower lip, inner aspect C00.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of nasopharynx. Malignant neoplasm of lateral wall of nasopharynx C11.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior wall of nasopharynx. Malignant neoplasm of anterior wall of nasopharynx C11.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of nasopharynx. Malignant neoplasm of overlapping sites of nasopharynx C11.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx, unspecified. Malignant neoplasm of nasopharynx, unspecified C11.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of pyriform sinus. Malignant neoplasm of pyriform sinus C12 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx. Malignant neoplasm of hypopharynx C13 ICD-10 code used to specify a diagnosis of malignant neoplasm of postcricoid region. Malignant neoplasm of postcricoid region C13.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect. Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect C13.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of hypopharynx. Malignant neoplasm of posterior wall of hypopharynx C13.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of hypopharynx. Malignant neoplasm of overlapping sites of hypopharynx C13.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified, inner aspect. Malignant neoplasm of lip, unspecified, inner aspect C00.5 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx, unspecified. Malignant neoplasm of hypopharynx, unspecified C13.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx. Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx C14 ICD-10 code used to specify a diagnosis of malignant neoplasm of pharynx, unspecified. Malignant neoplasm of pharynx, unspecified C14.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of Waldeyer's ring. Malignant neoplasm of Waldeyer's ring C14.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip, oral cavity and pharynx. Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx C14.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx. Malignant neoplasm of larynx C32 ICD-10 code used to specify a diagnosis of malignant neoplasm of glottis. Malignant neoplasm of glottis C32.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of supraglottis. Malignant neoplasm of supraglottis C32.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of subglottis. Malignant neoplasm of subglottis C32.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of laryngeal cartilage. Malignant neoplasm of laryngeal cartilage C32.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of commissure of lip, unspecified. Malignant neoplasm of commissure of lip, unspecified C00.6 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of larynx. Malignant neoplasm of overlapping sites of larynx C32.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx, unspecified. Malignant neoplasm of larynx, unspecified C32.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip. Malignant neoplasm of overlapping sites of lip C00.8 Absent Probable Present Not assessable Absent Probable Present Not assessable The tumor has not invaded the extrinsic muscles of the tongue When the tumor has not invaded the extrinsic muscles of the tongue. Absent There is no certainty that the tumor has invaded the extrinsic muscles of the tongue When there is no certainty that the tumor has invaded the extrinsic muscles of the tongue. Probable The tumor has invaded the extrinsic muscles of the tongue When the tumor has invaded the extrinsic muscles of the tongue. Present It is not possible to give an answer When it is not possible to give an answer. Not assessable When the tumor has not invaded the floor of the mouth. The tumor has not invaded the floor of the mouth Absent When there is no certainty that the tumor has invaded the floor of the mouth. There is no certainty that the tumor has invaded the floor of the mouth Probable When the tumor has invaded the floor of the mouth. The tumor has invaded the floor of the mouth Present When it is not possible to give an answer. It is not possible to give an answer Not assessable No Yes Malignant neoplasm of lip C00 Malignant neoplasm of lip, unspecified C00.9 Malignant neoplasm of base of tongue C01 Malignant neoplasm of other and unspecified parts of tongue C02 Malignant neoplasm of dorsal surface of tongue C02.0 Malignant neoplasm of border of tongue C02.1 Malignant neoplasm of ventral surface of tongue C02.2 Malignant neoplasm of anterior two-thirds of tongue, part unspecified C02.3 Malignant neoplasm of lingual tonsil C02.4 Malignant neoplasm of overlapping sites of tongue C02.8 Malignant neoplasm of tongue, unspecified C02.9 Malignant neoplasm of external upper lip C00.0 Malignant neoplasm of gum C03 Malignant neoplasm of upper gum C03.0 Malignant neoplasm of lower gum C03.1 Malignant neoplasm of gum, unspecified C03.9 Malignant neoplasm of floor of mouth C04 Malignant neoplasm of anterior floor of mouth C04.0 Malignant neoplasm of lateral floor of mouth C04.1 Malignant neoplasm of overlapping sites of floor of mouth C04.8 Malignant neoplasm of floor of mouth, unspecified C04.9 Malignant neoplasm of palate C05 Malignant neoplasm of external lower lip C00.1 Malignant neoplasm of hard palate C05.0 Malignant neoplasm of soft palate C05.1 Malignant neoplasm of uvula C05.2 Malignant neoplasm of overlapping sites of palate C05.8 Malignant neoplasm of palate, unspecified C05.9 Malignant neoplasm of other and unspecified parts of mouth C06 Malignant neoplasm of cheek mucosa C06.0 Malignant neoplasm of vestibule of mouth C06.1 Malignant neoplasm of retromolar area C06.2 Malignant neoplasm of parotid gland C07 Malignant neoplasm of external lip, unspecified C00.2 Malignant neoplasm of other and unspecified major salivary glands C08 Malignant neoplasm of submandibular gland C08.0 Malignant neoplasm of sublingual gland C08.1 Malignant neoplasm of major salivary gland, unspecified C08.9 Malignant neoplasm of tonsil C09 Malignant neoplasm of tonsillar fossa C09.0 Malignant neoplasm of tonsillar pillar (anterior) (posterior) C09.1 Malignant neoplasm of overlapping sites of tonsil C09.8 Malignant neoplasm of tonsil, unspecified C09.9 Malignant neoplasm of oropharynx C10 Malignant neoplasm of upper lip, inner aspect C00.3 Malignant neoplasm of vallecula C10.0 Malignant neoplasm of anterior surface of epiglottis C10.1 Malignant neoplasm of lateral wall of oropharynx C10.2 Malignant neoplasm of posterior wall of oropharynx C10.3 Malignant neoplasm of branchial cleft C10.4 Malignant neoplasm of overlapping sites of oropharynx C10.8 Malignant neoplasm of oropharynx, unspecified C10.9 Malignant neoplasm of nasopharynx C11 Malignant neoplasm of superior wall of nasopharynx C11.0 Malignant neoplasm of posterior wall of nasopharynx C11.1 Malignant neoplasm of lower lip, inner aspect C00.4 Malignant neoplasm of lateral wall of nasopharynx C11.2 Malignant neoplasm of anterior wall of nasopharynx C11.3 Malignant neoplasm of overlapping sites of nasopharynx C11.8 Malignant neoplasm of nasopharynx, unspecified C11.9 Malignant neoplasm of pyriform sinus C12 Malignant neoplasm of hypopharynx C13 Malignant neoplasm of postcricoid region C13.0 Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect C13.1 Malignant neoplasm of posterior wall of hypopharynx C13.2 Malignant neoplasm of overlapping sites of hypopharynx C13.8 Malignant neoplasm of lip, unspecified, inner aspect C00.5 Malignant neoplasm of hypopharynx, unspecified C13.9 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx C14 Malignant neoplasm of pharynx, unspecified C14.0 Malignant neoplasm of Waldeyer's ring C14.2 Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx C14.8 Malignant neoplasm of larynx C32 Malignant neoplasm of glottis C32.0 Malignant neoplasm of supraglottis C32.1 Malignant neoplasm of subglottis C32.2 Malignant neoplasm of laryngeal cartilage C32.3 Malignant neoplasm of commissure of lip, unspecified C00.6 Malignant neoplasm of overlapping sites of larynx C32.8 Malignant neoplasm of larynx, unspecified C32.9 Malignant neoplasm of overlapping sites of lip C00.8 CT MRI When the tumor has not invaded the internal carotid. The tumor has not invaded the internal carotid Absent When there is no certainty that the tumor has invaded the internal carotid. There is no certainty that the tumor has invaded the internal carotid Probable When the tumor has invaded the internal carotid. The tumor has invaded the internal carotid Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not infiltrated the bone. The tumor has not infiltrated the bone Absent When there is no certainty that the tumor has infiltrated the bone. There is no certainty that the tumor has infiltrated the bone Probable When the tumor has infiltrated the bone. The tumor has infiltrated the bone Present When it is not possible to give an answer. It is not possible to give an answer Not assessable No uptake. No uptake 0 Mild and/or homogeneous uptake. Mild and/or homogeneous uptake 1 Abundant and/or heterogeneous uptake. Abundant and/or heterogeneous uptake 2 Not evaluated. Not evaluated X Absent Present Left Right Midline IA IB IIA IIB III IV VA VB VI When the tumor has not invaded the masticator space. The tumor has not invaded the masticator space Absent When there is no certainty that the tumor has invaded the masticator space. There is no certainty that the tumor has invaded the masticator space Probable When the tumor has invaded the masticator space. The tumor has invaded the masticator space Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not invaded the maxillary sinus. The tumor has not invaded the maxillary sinus Absent When there is no certainty that the tumor has invaded the maxillary sinus. There is no certainty that the tumor has invaded the maxillary sinus Probable When the tumor has invaded the maxillary sinus. The tumor has invaded the maxillary sinus Present When it is not possible to give an answer. It is not possible to give an answer Not assessable 1 2 3 4 5 6 7 8 9 When the tumor has not invaded the orbit. The tumor has not invaded the orbit Absent When there is no certainty that the tumor has invaded the orbit. There is no certainty that the tumor has invaded the orbit Probable When the tumor has invaded the orbit. The tumor has invaded the orbit Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not invaded the oropharynx. The tumor has not invaded the oropharynx Absent When there is no certainty that the tumor has invaded the oropharynx. There is no certainty that the tumor has invaded the oropharynx Probable When the tumor has invaded the oropharynx. The tumor has invaded the oropharynx Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not invaded the parapharyngeal space. The tumor has not invaded the parapharyngeal space Absent When there is no certainty that the tumor has invaded the parapharyngeal space. There is no certainty that the tumor has invaded the parapharyngeal space Probable When the tumor has invaded the parapharyngeal space. The tumor has invaded the parapharyngeal space Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not invaded the nerve fibers. The tumor has not invaded the nerve fibers Absent When there is no certainty that the tumor has invaded the nerve fibers. There is no certainty that the tumor has invaded the nerve fibers Probable When the tumor has invaded the nerve fibers. The tumor has invaded the nerve fibers Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not infiltrated the periosteal. The tumor has not infiltrated the periosteal Absent When there is no certainty that the tumor has infiltrated the periosteal. There is no certainty that the tumor has infiltrated the periosteal Probable When the tumor has infiltrated the periosteal. The tumor has infiltrated the periosteal Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not invaded the pterygoid muscle. The tumor has not invaded the pterygoid muscle Absent When there is no certainty that the tumor has invaded the pterygoid muscle. There is no certainty that the tumor has invaded the pterygoid muscle Probable When the tumor has invaded the pterygoid muscle. The tumor has invaded the pterygoid muscle Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not invaded the pterygopalatine fossa. The tumor has not invaded the pterygopalatine fossa Absent When there is no certainty that the tumor has invaded the pterygopalatine fossa. There is no certainty that the tumor has invaded the pterygopalatine fossa Probable When the tumor has invaded the pterygopalatine fossa. The tumor has invaded the pterygopalatine fossa Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not invaded the retromolar trigone. The tumor has not invaded the retromolar trigone Absent When there is no certainty that the tumor has invaded the retromolar trigone. There is no certainty that the tumor has invaded the retromolar trigone Probable When the tumor has invaded the retromolar trigone. Wthe tumor has invaded the retromolar trigone Present When it is not possible to give an answer. It is not possible to give an answer Not assessable Ipsilateral Contralateral Bilateral When the tumor has not invaded the base of skull. The tumor has not invaded the base of skull Absent When there is no certainty that the tumor has invaded the base of skull. There is no certainty that the tumor has invaded the base of skull Probable When the tumor has invaded the base of skull. The tumor has invaded the base of skull Present When it is not possible to give an answer. It is not possible to give an answer Not assessable When the tumor has not spread through the midline of body. The tumor has not spread through the midline of body Absent When there is no certainty that the tumor has spread through the midline of body. There is no certainty that the tumor has spread through the midline of body Probable When the tumor has spread through the midline of body. The tumor has spread through the midline of body Present When it is not possible to give an answer. It is not possible to give an answer Not assessable Stage 0 Stage I Stage II Stage III Stage IVA Stage IVB Stage IVC Mx M0 M1 Nx N0 N1 N2a N2b N2c N3 T1 T2 T3 T4a T4b When the tumor has not infiltrated the bone. The tumor has not infiltrated the bone Absent When there is no certainty that the tumor has infiltrated the bone. There is no certainty that the tumor has infiltrated the bone Probable When the tumor has infiltrated the bone. The tumor has infiltrated the bone Present When it is not possible to give an answer. It is not possible to give an answer Not assessable No uptake. No uptake 0 Mild and/or homogeneous uptake. Mild and/or homogeneous uptake 1 Abundant and/or heterogeneous uptake. Abundant and/or heterogeneous uptake 2 Not evaluated. Not evaluated X Absent Present Left Right Midline ICD-10 code used to specify a diagnosis of malignant neoplasm of lip. Malignant neoplasm of lip C00 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified. Malignant neoplasm of lip, unspecified C00.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of base of tongue. Malignant neoplasm of base of tongue C01 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of tongue. Malignant neoplasm of other and unspecified parts of tongue C02 ICD-10 code used to specify a diagnosis of malignant neoplasm of dorsal surface of tongue. Malignant neoplasm of dorsal surface of tongue C02.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of border of tongue. Malignant neoplasm of border of tongue C02.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of ventral surface of tongue. Malignant neoplasm of ventral surface of tongue C02.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior two-thirds of tongue, part unspecified. Malignant neoplasm of anterior two-thirds of tongue, part unspecified C02.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of lingual tonsil. Malignant neoplasm of lingual tonsil C02.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tongue Malignant neoplasm of overlapping sites of tongue C02.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tongue, unspecified. Malignant neoplasm of tongue, unspecified C02.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of external upper lip. Malignant neoplasm of external upper lip C00.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum. Malignant neoplasm of gum C03 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper gum. Malignant neoplasm of upper gum C03.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower gum. Malignant neoplasm of lower gum C03.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum, unspecified. Malignant neoplasm of gum, unspecified C03.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth. Malignant neoplasm of floor of mouth C04 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior floor of mouth. Malignant neoplasm of anterior floor of mouth C04.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral floor of mouth. Malignant neoplasm of lateral floor of mouth C04.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of floor of mouth. Malignant neoplasm of overlapping sites of floor of mouth C04.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth, unspecified. Malignant neoplasm of floor of mouth, unspecified C04.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate. Malignant neoplasm of palate C05 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lower lip. Malignant neoplasm of external lower lip C00.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of hard palate. Malignant neoplasm of hard palate C05.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of soft palate. Malignant neoplasm of soft palate C05.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of uvula. Malignant neoplasm of uvula C05.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of palate. Malignant neoplasm of overlapping sites of palate C05.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate, unspecified. Malignant neoplasm of palate, unspecified C05.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of mouth. Malignant neoplasm of other and unspecified parts of mouth C06 ICD-10 code used to specify a diagnosis of malignant neoplasm of cheek mucosa. Malignant neoplasm of cheek mucosa C06.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of vestibule of mouth. Malignant neoplasm of vestibule of mouth C06.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of retromolar area. Malignant neoplasm of retromolar area C06.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of parotid gland. Malignant neoplasm of parotid gland C07 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lip, unspecified. Malignant neoplasm of external lip, unspecified C00.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified major salivary glands. Malignant neoplasm of other and unspecified major salivary glands C08 ICD-10 code used to specify a diagnosis of malignant neoplasm of submandibular gland. Malignant neoplasm of submandibular gland C08.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of sublingual gland. Malignant neoplasm of sublingual gland C08.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of major salivary gland, unspecified. Malignant neoplasm of major salivary gland, unspecified C08.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil. Malignant neoplasm of tonsil C09 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar fossa. Malignant neoplasm of tonsillar fossa C09.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar pillar (anterior) (posterior). Malignant neoplasm of tonsillar pillar (anterior) (posterior) C09.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tonsil. Malignant neoplasm of overlapping sites of tonsil C09.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil, unspecified. Malignant neoplasm of tonsil, unspecified C09.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx. Malignant neoplasm of oropharynx C10 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper lip, inner aspect. Malignant neoplasm of upper lip, inner aspect C00.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of vallecula. Malignant neoplasm of vallecula C10.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior surface of epiglottis. Malignant neoplasm of anterior surface of epiglottis C10.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of oropharynx. Malignant neoplasm of lateral wall of oropharynx C10.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of oropharynx. Malignant neoplasm of posterior wall of oropharynx C10.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of branchial cleft. Malignant neoplasm of branchial cleft C10.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of oropharynx. Malignant neoplasm of overlapping sites of oropharynx C10.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx, unspecified. Malignant neoplasm of oropharynx, unspecified C10.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx. Malignant neoplasm of nasopharynx C11 ICD-10 code used to specify a diagnosis of malignant neoplasm of superior wall of nasopharynx. Malignant neoplasm of superior wall of nasopharynx C11.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of nasopharynx. Malignant neoplasm of posterior wall of nasopharynx C11.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower lip, inner aspect. Malignant neoplasm of lower lip, inner aspect C00.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of nasopharynx. Malignant neoplasm of lateral wall of nasopharynx C11.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior wall of nasopharynx. Malignant neoplasm of anterior wall of nasopharynx C11.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of nasopharynx. Malignant neoplasm of overlapping sites of nasopharynx C11.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx, unspecified. Malignant neoplasm of nasopharynx, unspecified C11.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of pyriform sinus. Malignant neoplasm of pyriform sinus C12 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx. Malignant neoplasm of hypopharynx C13 ICD-10 code used to specify a diagnosis of malignant neoplasm of postcricoid region. Malignant neoplasm of postcricoid region C13.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect. Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect C13.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of hypopharynx. Malignant neoplasm of posterior wall of hypopharynx C13.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of hypopharynx. Malignant neoplasm of overlapping sites of hypopharynx C13.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified, inner aspect. Malignant neoplasm of lip, unspecified, inner aspect C00.5 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx, unspecified. Malignant neoplasm of hypopharynx, unspecified C13.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx. Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx C14 ICD-10 code used to specify a diagnosis of malignant neoplasm of pharynx, unspecified. Malignant neoplasm of pharynx, unspecified C14.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of Waldeyer's ring. Malignant neoplasm of Waldeyer's ring C14.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip, oral cavity and pharynx. Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx C14.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx. Malignant neoplasm of larynx C32 ICD-10 code used to specify a diagnosis of malignant neoplasm of glottis. Malignant neoplasm of glottis C32.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of supraglottis. Malignant neoplasm of supraglottis C32.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of subglottis. Malignant neoplasm of subglottis C32.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of laryngeal cartilage. Malignant neoplasm of laryngeal cartilage C32.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of commissure of lip, unspecified. Malignant neoplasm of commissure of lip, unspecified C00.6 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of larynx. Malignant neoplasm of overlapping sites of larynx C32.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx, unspecified. Malignant neoplasm of larynx, unspecified C32.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip. Malignant neoplasm of overlapping sites of lip C00.8 3mm 3mm ≤ 9mm >9mm No Yes None Mild Moderate High Not evaluable No ≤2mm >2mm Soft tissue invasion Not applicable Not evaluable Undetermined. Gx Tumor grade in which cancer cells are well differentiated from normal cells. Well differentiated G1 Tumor grade in which cancer cells are moderately differentiated from normal cells. Moderately differentiated G2 Tumor grade in which cancer cells are poorly differentiated from normal cells. Poorly differentiated G3 Tumor grade in which cancer cells are undifferentiated from normal cells. Undifferentiated. G4 Not done Unknown Not applicable Negative Positive Positive Negative Unknown DNA PCR RNA RT-PCR ISH No HPV test Unknown Microinvasion Lamina propria Muscle Bone Other Not evaluable None Mild Moderate Marked Not evaluable No Yes Not evaluable None Mild Moderate Marked Extreme Not evaluable Cohesive Focal non cohesive <50% Extensive non cohesive Not evaluable No Focal (1 slides) Extensive (all slides) Not evaluable ICD-10 code used to specify a diagnosis of malignant neoplasm of lip. Malignant neoplasm of lip C00 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified. Malignant neoplasm of lip, unspecified C00.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of base of tongue. Malignant neoplasm of base of tongue C01 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of tongue. Malignant neoplasm of other and unspecified parts of tongue C02 ICD-10 code used to specify a diagnosis of malignant neoplasm of dorsal surface of tongue. Malignant neoplasm of dorsal surface of tongue C02.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of border of tongue. Malignant neoplasm of border of tongue C02.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of ventral surface of tongue. Malignant neoplasm of ventral surface of tongue C02.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior two-thirds of tongue, part unspecified. Malignant neoplasm of anterior two-thirds of tongue, part unspecified C02.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of lingual tonsil. Malignant neoplasm of lingual tonsil C02.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tongue. Malignant neoplasm of overlapping sites of tongue C02.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tongue, unspecified. Malignant neoplasm of tongue, unspecified C02.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of external upper lip. Malignant neoplasm of external upper lip C00.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum. Malignant neoplasm of gum C03 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper gum. Malignant neoplasm of upper gum C03.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower gum. Malignant neoplasm of lower gum C03.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum, unspecified. Malignant neoplasm of gum, unspecified C03.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth. Malignant neoplasm of floor of mouth C04 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior floor of mouth. Malignant neoplasm of anterior floor of mouth C04.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral floor of mouth. Malignant neoplasm of lateral floor of mouth C04.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of floor of mouth. Malignant neoplasm of overlapping sites of floor of mouth C04.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth, unspecified. Malignant neoplasm of floor of mouth, unspecified C04.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate. Malignant neoplasm of palate C05 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lower lip. Malignant neoplasm of external lower lip C00.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of hard palate. Malignant neoplasm of hard palate C05.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of soft palate. Malignant neoplasm of soft palate C05.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of uvula. Malignant neoplasm of uvula C05.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of palate. Malignant neoplasm of overlapping sites of palate C05.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate, unspecified. Malignant neoplasm of palate, unspecified C05.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of mouth. Malignant neoplasm of other and unspecified parts of mouth C06 ICD-10 code used to specify a diagnosis of malignant neoplasm of cheek mucosa. Malignant neoplasm of cheek mucosa C06.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of vestibule of mouth. Malignant neoplasm of vestibule of mouth C06.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of retromolar area. Malignant neoplasm of retromolar area C06.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of parotid gland. Malignant neoplasm of parotid gland C07 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lip, unspecified. Malignant neoplasm of external lip, unspecified C00.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified major salivary glands. Malignant neoplasm of other and unspecified major salivary glands C08 ICD-10 code used to specify a diagnosis of malignant neoplasm of submandibular gland. Malignant neoplasm of submandibular gland C08.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of sublingual gland. Malignant neoplasm of sublingual gland C08.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of major salivary gland, unspecified. Malignant neoplasm of major salivary gland, unspecified C08.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil. Malignant neoplasm of tonsil C09 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar fossa. Malignant neoplasm of tonsillar fossa C09.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar pillar (anterior) (posterior). Malignant neoplasm of tonsillar pillar (anterior) (posterior) C09.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tonsil. Malignant neoplasm of overlapping sites of tonsil C09.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil, unspecified. Malignant neoplasm of tonsil, unspecified C09.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx. Malignant neoplasm of oropharynx C10 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper lip, inner aspect. Malignant neoplasm of upper lip, inner aspect C00.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of vallecula. Malignant neoplasm of vallecula C10.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior surface of epiglottis. Malignant neoplasm of anterior surface of epiglottis C10.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of oropharynx. Malignant neoplasm of lateral wall of oropharynx C10.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of oropharynx. Malignant neoplasm of posterior wall of oropharynx C10.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of branchial cleft. Malignant neoplasm of branchial cleft C10.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of oropharynx. Malignant neoplasm of overlapping sites of oropharynx C10.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx, unspecified. Malignant neoplasm of oropharynx, unspecified C10.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx. Malignant neoplasm of nasopharynx C11 ICD-10 code used to specify a diagnosis of malignant neoplasm of superior wall of nasopharynx. Malignant neoplasm of superior wall of nasopharynx C11.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of nasopharynx. Malignant neoplasm of posterior wall of nasopharynx C11.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower lip, inner aspect. Malignant neoplasm of lower lip, inner aspect C00.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of nasopharynx. Malignant neoplasm of lateral wall of nasopharynx C11.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior wall of nasopharynx. Malignant neoplasm of anterior wall of nasopharynx C11.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of nasopharynx. Malignant neoplasm of overlapping sites of nasopharynx C11.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx, unspecified. Malignant neoplasm of nasopharynx, unspecified C11.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of pyriform sinus. Malignant neoplasm of pyriform sinus C12 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx. Malignant neoplasm of hypopharynx C13 ICD-10 code used to specify a diagnosis of malignant neoplasm of postcricoid region. Malignant neoplasm of postcricoid region C13.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect. Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect C13.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of hypopharynx. Malignant neoplasm of posterior wall of hypopharynx C13.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of hypopharynx. Malignant neoplasm of overlapping sites of hypopharynx C13.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified, inner aspect. Malignant neoplasm of lip, unspecified, inner aspect C00.5 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx, unspecified. Malignant neoplasm of hypopharynx, unspecified C13.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx. Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx C14 ICD-10 code used to specify a diagnosis of malignant neoplasm of pharynx, unspecified. Malignant neoplasm of pharynx, unspecified C14.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of Waldeyer's ring. Malignant neoplasm of Waldeyer's ring C14.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip, oral cavity and pharynx. Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx C14.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx. Malignant neoplasm of larynx C32 ICD-10 code used to specify a diagnosis of malignant neoplasm of glottis. Malignant neoplasm of glottis C32.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of supraglottis. Malignant neoplasm of supraglottis C32.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of subglottis. Malignant neoplasm of subglottis C32.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of laryngeal cartilage. Malignant neoplasm of laryngeal cartilage C32.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of commissure of lip, unspecified. Malignant neoplasm of commissure of lip, unspecified C00.6 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of larynx. Malignant neoplasm of overlapping sites of larynx C32.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx, unspecified. Malignant neoplasm of larynx, unspecified C32.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip. Malignant neoplasm of overlapping sites of lip C00.8 Involved (<1 mm) Close (1-5 mm) Clear (>5 mm) N0 N1 N2a N2b N2c N3 pNX pN0 pN1 pN2a pN2b pN2c pN3a pN3b NX N0 Alphanumeric code of the TNM classification system (8th Edition) which in this case indicates that the oropharynx cancer (p16-Positive) has spread to 4 or fewer lymph nodes. Metastasis in 4 or fewer lymph nodes N1 Alphanumeric code of the TNM classification system (8th Edition) which in this case indicates that the oropharynx cancer (p16-Positive) has spread to more than 4 lymph nodes. Metastasis in more than 4 lymph nodes N2 Tis T1 T2 T3 T4a T4b Tis T1 T2 T3 T4a T4b T1 T2 T3 T4 Resection specimen Biopsy ≤5mm >5mm and ≤10mm >10mm Negative Positive No Yes 0% 90% 100% 10% 20% 30% 40% 50% 60% 70% 80% Yes - Patient Yes - Next of Kin/Legal Representative Not Applicable Yes No Normal Liquid diet Semi-liquid diet Gastrostomy SNG Normal Permanent tracheotomy Unilateral neck Bilateral neck 1.8-2 Gy die (conventional) Up to 1.2 x2 frs/die bifractionation Up to 2.2 Gy (moderately acceleration with SIB (IMRT)) Over 2.2 Gy (acceleration with SIB) Other No Yes Treatment completed Progression Toxicity Other Radiotherapy configuration in which radiotherapy is the main treatment. Radiotherapy is the main treatment Definitive Radiotherapy configuration in which radiotherapy is perforomed after surgery. Radiotherapy is performed after surgery Postoperative Gross Target Volume of the primary tumor. Selected when only the primary tumor is irradiated. GTVT (definitive cases only) Gross Target Volume of positive lymph nodes. Selected when only lymph nodes are irradiated. GTVN (definitive cases only) Global gross target Volume including primary tumor and lymph nodes. Selected when both primary tumor and lymph nodes are irradiated. total GTV (definitive cases only) A procedure that uses a computer to create a 3-dimensional picture of the tumor. This allows doctors to give the highest possible dose of radiation to the tumor, while sparing the normal tissue as much as possible. Also called 3-dimensional conformal radiation therapy and 3-dimensional radiation therapy. 3D-RT Intensity-modulated radiation therapy: a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. Also called IMRT. Conventional IMRT VMAT A type of therapy in which radiation is aimed at a tumor from many different directions. The patient lays on a table and is moved through a donut-shaped machine. The radiation source in the machine rotates around the patient in a spiral pattern. Before radiation, a 3-dimensional (3-D) image of the tumor is taken. This helps doctors find the highest dose of radiation that can be used to kill tumor cells while causing less damage to nearby tissue. Tomotherapy is a type of intensity-modulated radiation therapy (IMRT). Also called helical tomotherapy. Tomotherapy RiskFactors:Alcohol_at_Time_of_Diagnosis An indication of a person's current alcohol consumption as well as some indication of alcohol consumption history. No Leukoplakia Lichen ruben planus Erythroplakia Oral submucous fibrosis No Leukoplakia Lichen ruben planus Erythroplakia Oral submucous fibrosis Current Former Never Unknown No Yes Unknown No Yes Unknown ICD-10 code used to specify a diagnosis of malignant neoplasm of lip. Malignant neoplasm of lip C00 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified. Malignant neoplasm of lip, unspecified C00.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of base of tongue. Malignant neoplasm of base of tongue C01 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of tongue. Malignant neoplasm of other and unspecified parts of tongue C02 ICD-10 code used to specify a diagnosis of malignant neoplasm of dorsal surface of tongue. Malignant neoplasm of dorsal surface of tongue C02.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of border of tongue. Malignant neoplasm of border of tongue C02.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of ventral surface of tongue. Malignant neoplasm of ventral surface of tongue C02.2 Specific ICD-10 code that refers to a malignant neoplasm of anterior two-thirds of tongue, part unspecified. Malignant neoplasm of anterior two-thirds of tongue, part unspecified C02.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of lingual tonsil. Malignant neoplasm of lingual tonsil C02.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tongue. Malignant neoplasm of overlapping sites of tongue C02.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tongue, unspecified. Malignant neoplasm of tongue, unspecified C02.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of external upper lip. Malignant neoplasm of external upper lip C00.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum. Malignant neoplasm of gum C03 ICD-10 code used to specify a diagnosis of malignant neoplasmof upper gum. Malignant neoplasm of upper gum C03.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower gum. Malignant neoplasm of lower gum C03.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum, unspecified. Malignant neoplasm of gum, unspecified C03.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth. Malignant neoplasm of floor of mouth C04 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior floor of mouth. Malignant neoplasm of anterior floor of mouth C04.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral floor mouth. Malignant neoplasm of lateral floor of mouth C04.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of floor of mouth. Malignant neoplasm of overlapping sites of floor of mouth C04.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth, unspecified. Malignant neoplasm of floor of mouth, unspecified C04.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate. Malignant neoplasm of palate C05 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lower lip. Malignant neoplasm of external lower lip C00.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of hard palate. Malignant neoplasm of hard palate C05.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of soft palate. Malignant neoplasm of soft palate C05.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of uvula. Malignant neoplasm of uvula C05.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of palate. Malignant neoplasm of overlapping sites of palate C05.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate, unspecified. Malignant neoplasm of palate, unspecified C05.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of mouth. Malignant neoplasm of other and unspecified parts of mouth C06 ICD-10 code used to specify a diagnosis of malignant neoplasm of cheek mucosa. Malignant neoplasm of cheek mucosa C06.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of vestibule of mouth. Malignant neoplasm of vestibule of mouth C06.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of retromolar area. Malignant neoplasm of retromolar area C06.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of parotid gland. Malignant neoplasm of parotid gland C07 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lip, unspecified. Malignant neoplasm of external lip, unspecified C00.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified major salivary glands. Malignant neoplasm of other and unspecified major salivary glands C08 ICD-10 code used to specify a diagnosis of malignant neoplasm of submandibular gland. Malignant neoplasm of submandibular gland C08.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of sublingual gland. Malignant neoplasm of sublingual gland C08.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of major salivary gland, unspecified. Malignant neoplasm of major salivary gland, unspecified C08.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil. Malignant neoplasm of tonsil C09 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar fossa. Malignant neoplasm of tonsillar fossa C09.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar pillar (anterior) (posterior). Malignant neoplasm of tonsillar pillar (anterior) (posterior) C09.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tonsil. Malignant neoplasm of overlapping sites of tonsil C09.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil, unspecified. Malignant neoplasm of tonsil, unspecified C09.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx. Malignant neoplasm of oropharynx C10 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper lip, inner aspect. Malignant neoplasm of upper lip, inner aspect C00.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of vallecula. Malignant neoplasm of vallecula C10.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior surface of epiglottis. Malignant neoplasm of anterior surface of epiglottis C10.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of oropharynx. Malignant neoplasm of lateral wall of oropharynx C10.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of oropharynx. Malignant neoplasm of posterior wall of oropharynx C10.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of branchial cleft. Malignant neoplasm of branchial cleft C10.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of oropharynx. Malignant neoplasm of overlapping sites of oropharynx C10.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx, unspecified. Malignant neoplasm of oropharynx, unspecified C10.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx. Malignant neoplasm of nasopharynx C11 ICD-10 code used to specify a diagnosis of malignant neoplasm of superior wall of nasopharynx. Malignant neoplasm of superior wall of nasopharynx C11.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of nasopharynx. Malignant neoplasm of posterior wall of nasopharynx C11.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower lip, inner aspect. Malignant neoplasm of lower lip, inner aspect C00.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of nasopharynx. Malignant neoplasm of lateral wall of nasopharynx C11.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior wall of nasopharynx. Malignant neoplasm of anterior wall of nasopharynx C11.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of nasopharynx. Malignant neoplasm of overlapping sites of nasopharynx C11.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx, unspecified. Malignant neoplasm of nasopharynx, unspecified C11.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of pyriform sinus. Malignant neoplasm of pyriform sinus C12 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx. Malignant neoplasm of hypopharynx C13 ICD-10 code used to specify a diagnosis of malignant neoplasm of postcricoid region. Malignant neoplasm of postcricoid region C13.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect. Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect C13.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of hypopharynx. Malignant neoplasm of posterior wall of hypopharynx C13.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of hypopharynx. Malignant neoplasm of overlapping sites of hypopharynx C13.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified, inner aspect. Malignant neoplasm of lip, unspecified, inner aspect C00.5 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx, unspecified. Malignant neoplasm of hypopharynx, unspecified C13.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx. Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx C14 ICD-10 code used to specify a diagnosis of malignant neoplasm of pharynx, unspecified. Malignant neoplasm of pharynx, unspecified C14.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of Waldeyer's ring. Malignant neoplasm of Waldeyer's ring C14.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip, oral cavity and pharynx. Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx C14.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx. Malignant neoplasm of larynx C32 ICD-10 code used to specify a diagnosis of malignant neoplasm of glottis. Malignant neoplasm of glottis C32.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of supraglottis. Malignant neoplasm of supraglottis C32.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of subglottis. Malignant neoplasm of subglottis C32.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of laryngeal cartilage. Malignant neoplasm of laryngeal cartilage C32.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of commissure of lip, unspecified. Malignant neoplasm of commissure of lip, unspecified C00.6 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of larynx. Malignant neoplasm of overlapping sites of larynx C32.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx, unspecified. Malignant neoplasm of larynx, unspecified C32.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip. Malignant neoplasm of overlapping sites of lip C00.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip. Malignant neoplasm of lip C00 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified. Malignant neoplasm of lip, unspecified C00.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of base of tongue. Malignant neoplasm of base of tongue C01 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of tongue. Malignant neoplasm of other and unspecified parts of tongue C02 ICD-10 code used to specify a diagnosis of malignant neoplasm of dorsal surface of tongue. Malignant neoplasm of dorsal surface of tongue C02.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of border of tongue. Malignant neoplasm of border of tongue C02.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of ventral surface of tongue. Malignant neoplasm of ventral surface of tongue C02.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior two-thirds of tongue, part unspecified. Malignant neoplasm of anterior two-thirds of tongue, part unspecified C02.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of lingual tonsil. Malignant neoplasm of lingual tonsil C02.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tongue. Malignant neoplasm of overlapping sites of tongue C02.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tongue, unspecified. Malignant neoplasm of tongue, unspecified C02.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of external upper lip. Malignant neoplasm of external upper lip C00.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum. Malignant neoplasm of gum C03 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper gum. Malignant neoplasm of upper gum C03.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower gum. Malignant neoplasm of lower gum C03.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of gum, unspecified. Malignant neoplasm of gum, unspecified C03.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth. Malignant neoplasm of floor of mouth C04 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior floor of mouth. Malignant neoplasm of anterior floor of mouth C04.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral floor of mouth. Malignant neoplasm of lateral floor of mouth C04.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of floor of mouth. Malignant neoplasm of overlapping sites of floor of mouth C04.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of floor of mouth, unspecified. Malignant neoplasm of floor of mouth, unspecified C04.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate. Malignant neoplasm of palate C05 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lower lip. Malignant neoplasm of external lower lip C00.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of hard palate. Malignant neoplasm of hard palate C05.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of soft palate. Malignant neoplasm of soft palate C05.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of uvula. Malignant neoplasm of uvula C05.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of palate. Malignant neoplasm of overlapping sites of palate C05.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of palate, unspecified. Malignant neoplasm of palate, unspecified C05.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified parts of mouth. Malignant neoplasm of other and unspecified parts of mouth C06 ICD-10 code used to specify a diagnosis of malignant neoplasm of cheek mucosa. Malignant neoplasm of cheek mucosa C06.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of vestibule of mouth. Malignant neoplasm of vestibule of mouth C06.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of retromolar area. Malignant neoplasm of retromolar area C06.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of parotid gland. Malignant neoplasm of parotid gland C07 ICD-10 code used to specify a diagnosis of malignant neoplasm of external lip, unspecified. Malignant neoplasm of external lip, unspecified C00.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and unspecified major salivary glands. Malignant neoplasm of other and unspecified major salivary glands C08 ICD-10 code used to specify a diagnosis of malignant neoplasm of submandibular gland. Malignant neoplasm of submandibular gland C08.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of sublingual gland. Malignant neoplasm of sublingual gland C08.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of major salivary gland, unspecified. Malignant neoplasm of major salivary gland, unspecified C08.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil. Malignant neoplasm of tonsil C09 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar fossa. Malignant neoplasm of tonsillar fossa C09.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsillar pillar (anterior) (posterior). Malignant neoplasm of tonsillar pillar (anterior) (posterior) C09.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of tonsil. Malignant neoplasm of overlapping sites of tonsil C09.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of tonsil, unspecified. Malignant neoplasm of tonsil, unspecified C09.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx. Malignant neoplasm of oropharynx C10 ICD-10 code used to specify a diagnosis of malignant neoplasm of upper lip, inner aspect. Malignant neoplasm of upper lip, inner aspect C00.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of vallecula. Malignant neoplasm of vallecula C10.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior surface of epiglottis. Malignant neoplasm of anterior surface of epiglottis C10.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of oropharynx. Malignant neoplasm of lateral wall of oropharynx C10.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of oropharynx. Malignant neoplasm of posterior wall of oropharynx C10.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of branchial cleft. Malignant neoplasm of branchial cleft C10.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of oropharynx. Malignant neoplasm of overlapping sites of oropharynx C10.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of oropharynx, unspecified. Malignant neoplasm of oropharynx, unspecified C10.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx. Malignant neoplasm of nasopharynx C11 ICD-10 code used to specify a diagnosis of malignant neoplasm of superior wall of nasopharynx. Malignant neoplasm of superior wall of nasopharynx C11.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of nasopharynx. Malignant neoplasm of posterior wall of nasopharynx C11.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of lower lip, inner aspect. Malignant neoplasm of lower lip, inner aspect C00.4 ICD-10 code used to specify a diagnosis of malignant neoplasm of lateral wall of nasopharynx. Malignant neoplasm of lateral wall of nasopharynx C11.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of anterior wall of nasopharynx. Malignant neoplasm of anterior wall of nasopharynx C11.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of nasopharynx. Malignant neoplasm of overlapping sites of nasopharynx C11.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of nasopharynx, unspecified. Malignant neoplasm of nasopharynx, unspecified C11.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of pyriform sinus. Malignant neoplasm of pyriform sinus C12 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx. Malignant neoplasm of hypopharynx C13 ICD-10 code used to specify a diagnosis of malignant neoplasm of postcricoid region. Malignant neoplasm of postcricoid region C13.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect. Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect C13.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of posterior wall of hypopharynx. Malignant neoplasm of posterior wall of hypopharynx C13.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of hypopharynx. Malignant neoplasm of overlapping sites of hypopharynx C13.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of lip, unspecified, inner aspect. Malignant neoplasm of lip, unspecified, inner aspect C00.5 ICD-10 code used to specify a diagnosis of malignant neoplasm of hypopharynx, unspecified. Malignant neoplasm of hypopharynx, unspecified C13.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx. Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx C14 ICD-10 code used to specify a diagnosis of malignant neoplasm of pharynx, unspecified. Malignant neoplasm of pharynx, unspecified C14.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of Waldeyer's ring. Malignant neoplasm of Waldeyer's ring C14.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip, oral cavity and pharynx. Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx C14.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx. Malignant neoplasm of larynx C32 ICD-10 code used to specify a diagnosis of malignant neoplasm of glottis. Malignant neoplasm of glottis C32.0 ICD-10 code used to specify a diagnosis of malignant neoplasm of supraglottis. Malignant neoplasm of supraglottis C32.1 ICD-10 code used to specify a diagnosis of malignant neoplasm of subglottis. Malignant neoplasm of subglottis C32.2 ICD-10 code used to specify a diagnosis of malignant neoplasm of laryngeal cartilage. Malignant neoplasm of laryngeal cartilage C32.3 ICD-10 code used to specify a diagnosis of malignant neoplasm of commissure of lip, unspecified. Malignant neoplasm of commissure of lip, unspecified C00.6 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of larynx. Malignant neoplasm of overlapping sites of larynx C32.8 ICD-10 code used to specify a diagnosis of malignant neoplasm of larynx, unspecified. Malignant neoplasm of larynx, unspecified C32.9 ICD-10 code used to specify a diagnosis of malignant neoplasm of overlapping sites of lip. Malignant neoplasm of overlapping sites of lip C00.8 Good Intermediate Poor Not available Current Former Never Unknown Cigarettes Cigar/pipes Betel quid Smokeless(spit) tobacco No Yes A procedure to remove or repair a part of the body or to find out whether disease is present. An operation or in case of action for complications, surgery that is perfomed to improve the situation or recover after a surgical complication. Further surgery Closely watching a patient’s condition but not giving treatment unless symptoms appear or change. Watchful waiting is sometimes used in conditions that progress slowly. It is also used when the risks of treatment are greater than the possible benefits. During watchful waiting, patients may be given certain tests and exams. Nothing waiting and observation Medical treatment in which an ambient preassure greater than sea level atmospheric pressure is used to improve e.g. wound healing. Hyperbaric radiotherapy Other Selective Modified Radical Radical Removal and examination of the sentinel node(s) (the first lymph node(s) to which cancer cells are likely to spread from a primary tumor). To identify the sentinel lymph node(s), the surgeon injects a radioactive substance, blue dye, or both near the tumor. The surgeon then uses a probe to find the sentinel lymph node(s) containing the radioactive substance or looks for the lymph node(s) stained with dye. The surgeon then removes the sentinel node(s) to check for the presence of cancer cells. Sentinel node biopsy Selective Modified Radical Radical Removal and examination of the sentinel node(s) (the first lymph node(s) to which cancer cells are likely to spread from a primary tumor). To identify the sentinel lymph node(s), the surgeon injects a radioactive substance, blue dye, or both near the tumor. The surgeon then uses a probe to find the sentinel lymph node(s) containing the radioactive substance or looks for the lymph node(s) stained with dye. The surgeon then removes the sentinel node(s) to check for the presence of cancer cells Sentinel node biopsy Open/Conventional surgery A surgical procedure that uses the cutting power of a laser beam to make bloodless cuts in tissue or to remove a surface lesion such as a tumor. Laser surgery No Yes No Yes Right Left Bilateral Left Right Midline A term used to describe the original, or first, tumor in the body. Cancer cells from a primary cancer may spread to other parts of the body and form new, or secondary, tumors. This is called metastasis. These secondary tumors are the same type of cancer as the primary cancer. Also called primary tumor. Primary Tumor Cancer that has recurred (come back), usually after a period of time during which the cancer could not be detected. The cancer may come back to the same place as the original (primary) tumor or to another place in the body. Also called recurrent cancer. Recurrence Other Surgical reconstruction technique in which the removed tissue has no direct blood connection by local vessels or locally surgically connected vessels while being transferred. There is no direct blood connection by local vessels or locally surgically connected vessels Free flaps Healthy skin, bone, or other tissue taken from one part of the body and used to replace diseased or injured tissue removed from another part of the body. Graft Surgical reconstruction technique in which the local tissue next to the removed tissue is used for reconstruction. The local tissue next to the removed tissue is used for reconstrucion Local flaps Surgical reconstruction technique in which the local and connected tissue of the region is used for reconstruction. The local and connected tissue of the region is used for reconstruction Loco-Regional flaps Type of surgical reconstruction in which the wound/defect is either directly closed or left open for primary wound healing (e.g. laser surgery od the larynx). No reconstrucion by grafts and/or flaps is performed. No reconstrucion by grafts and/or flaps is performed. The wound/defect is either directly closed or left open for primary wound healing (e.g. laser surgery od the larynx) Primary closure No Yes Wound infection Intraoperative hemorrhage Postoperative hemorrhage Wound complication Wound dehiscence Loss of skin during or mostly after a surgical procedure. Skin loss Necrosis of a flap during or mostly after surgery due to infection, local thrombosis, loss of perfusion or adaption or for other reasons. Flap necrosis An abnormal opening or passage between two organs or between an organ and the surface of the body. Fistulas may be caused by injury, infection, or inflammation, or may be created during surgery. Fistula Other Surgerical procedure that removes parts of the tongue or even the whole organ. Glossectomy Surgery that removes parts of the floor of the mouth. Surgery –Floor of the mouth Total surgical removement of the larynx. Total Laryngectomy Resection Other Surgery that removes parts of the larynx and pharynx or even the whole organ (in case of the larynx). Laryngopharyngectomy Surgery that removes parts of/the whole mandibula. Mandibulectomy Surgery that removes parts of the maxilla. Maxillectomy Surgery that removes parts of the oropharynx with a reconstruction of the mandibula. Oropharyngeal resection with mandible split/reconstruction Surgery that removes parts of the oropharynx. Oropharyngeal tumor resection Surgery that removes parts of the larynx but not the whole organ. Partial laryngeal resection Surgery that removes parts of the pharynx. Pharyngectomy Surgery that removes at least parts of the orbital floor or even the whole structure. Surgery – Orbital Floor Resection No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes Available Not available Available Not available Available Not available No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes