Gail H. Deutsch Huaqin Pan NHLBI Molecular Atlas of Lung Development Program Consortium Ontology Subcommittee Susan E Wert BFO:0000050 part of RO:0002202 develops_from http://purl.obolibrary.org/obo/CL_0000057 A connective tissue cell that secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appears fusiform or spindle-shaped. LMMA:00007 matrix synthesizing fibroblast matrix fibroblast LMMA:00007 A cuboidal epithelial cell that lines the branching acinar tubules of the peripheral fetal lung. These tubules are formed during the pseudoglandular stage of lung development (E12.5 - E16.5). They are called "acinar tubules", since they will become the mature pulmonary acinus (alveolar duct and alveoli) in the adult lung. LMMA:00052 acinar epithelial cell LMMA:00052 A connective tissue cell specialized to synthesize and store fat, primarily in the form of triglycerides. CL:0000136 LMHA:00054 LMMA:00054 adipocyte LMMA:00054 A mesenchymal-derived connective tissue cell located in the interstitial space (interstitium or connective tissue compartment) of the alveolar septum (wall). LMHA:00066 LMMA:00066 alveolar connective tissue cell alveolar stromal cell alveolar interstitial cell LMMA:00066 CL:0000236 LMHA:00086 LMMA:00086 Type of white blood cell, or leukocyte, of the B lymphocyte lineage that includes antibody secreting cells (plasma cells, memory B cells, follicular and marginal zone B cells) that function in the body's antibody-driven humoral adaptive immunity. Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). B cell B Lymphocyte LMMA:00086 An epithelial cell located at the base, or basal side, of the epithelium, in direct contact with the underlying basement membrane. These are small polyhedral cells with a large nucleus, relatively little cytoplasm and few organelles. They are undifferentiated, self-renewing, multipotent, progenitor (stem) cells for other epithelial cell types in the airway. CL:0000646 LMHA:00087 LMMA:00087 true basal cell LMMA:00087 CL:0000767 LMHA:00090 LMMA:00090 A granular leukocyte with coarse, bluish-black granules. Basophils mediate hypersensitivity reactions and contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation basophilic granulocyte basophilic leukocyte basophil LMMA:00090 A rare, cholinergic, chemosensory, epithelial cell located in the upper respiratory tract, larynx, and trachea, as well as in the ducts of the submucosal glands. This cell expresses "bitter" taste receptors (TAS2R) and is responsible for detecting chemical irritants that trigger a variety of reflex responses, such as coughing, This cell also called a "brush" cell, based on a brush-like tuft of microvilli located on its apical cell surface. LMMA:00125 brush cell chemosensory cell LMMA:00125 LMMA:00132 true cardiac myocyte cardiomyocyte LMMA:00132 A group of cells derived from embryonic mesoderm (mesenchyme) that includes fibroblasts, cartilage cells, adipocytes, smooth muscle cells and bone cells. CL:0002320 LMHA:00136 LMMA:00136 connective tissue cell LMMA:00136 A mesenchymal-derived, connective tissue cell located in the interstitial space (interstitium or connective tissue compartment) between the branching acinar tubules of the peripheral fetal lung during the pseudoglandular stage of lung development (E12.5 - E16.5). LMMA:00137 pre-alveolar acinar stromal cell pre-alveolar connective tissue cell pre-alveolar mesenchymal cell pre-alveolar interstitial cell LMMA:00137 A type of connective tissue cell that secretes and maintains the structural components of cartilage, primarily collagen and proteoglycans. BTO:0000249 LMHA:00141 LMMA:00141 true chondrocyte LMMA:00141 A columnar epithelial cell with microscopic hair-like processes, i.e., motile cilia, that extend from the apical cell surface. These cells are found in the epithelia of the conducting airways (trachea, bronchi, and bronchioles), where they sweep mucous, dirt, dust, bacteria and other pathogens up and out of the lung, bronchi, and trachea. CL:0000064 LMHA:00142 LMMA:00142 true ciliated cell LMMA:00142 The club cell is a non-ciliated, dome-shaped, secretory cell with short microvilli and abundant secretory granules. Its secretory proteins function to protect the bronchiolar epithelium from environmental toxins/irritants. The club cell also has the capacity for self-renewal (maintenance of a progenitor cell pool) and regeneration of the bronchiolar epithelium after injury. CL:0000158 LMHA:00143 LMMA:00143 true Clara cell bronchiolar exocrine cell nonciliated secretory cell club cell LMMA:00143 An epithelial cell located in the ducts (tube-like structures) that transport seromucous secretions from the submucosal glands to the lumen of the upper trachea in the mouse and to the lumen of the cartilaginous airways in the human. LMHA:00146 LMMA:00146 collecting duct cell LMMA:00146 CL:0000738 LMHA:00150 LMMA:00150 A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative. dendritic cell LMMA:00150 A mesenchymal-derived, polygonal, rounded, flat, or squamous ("scale-like") cell that lines the inner (luminal) surface of the blood vessels and lymphaic vessels. These cells contain vimentin filaments and are held together by junctional complexes to form a thin, continuous, endothelial cell layer or sheath (endothelium). LMMA:00161 END endothelial cell LMMA:00161 CL:0000771 LMHA:00163 LMMA:00163 A granular leukocyte with cytoplasm containing coarse, round granules which can be stained by the dye eosin. Eosinophils contain histamines and other enzymatic proteins, such as esoinophil peroxidase, RNase, DNase, and lipase, as well as plasminogen and major basic protein, which are released by degarnulation following activation. These cells play a specialized role in immunity to parasitic infections, and are the primary inflammatory cells in allergic reactions, such as asthma, hay fever, and hives. eosinophil LMMA:00163 Cells that line the inner and outer surfaces of the body by forming single or mutliple cell layers or sheets (epithelia). Epithelial cells lining the respiratory system are derived from endoderm. Epithelial cells can be classified by cell shape into squamous, cuboidal, columnar, and transitional epithelial cells. They have a cytoskeleton that allows for tight cell-to-cell contact and cell polarity. LMMA:00164 EPI epithelial cell LMMA:00164 A connective tissue cell that secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. LMMA:00169 true fibroblast LMMA:00169 CL:0000094 LMHA:00179 LMMA:00179 granulocyte LMMA:00179 CL:0000235 LMHA:00182 LMMA:00182 A mononuclear phagocyte of the myeloid lineage that is present in a variety of tissues, typically differentiated from monocytes, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. Additional functions include anitgen presentation and tissue remodeling. This phagocyte is large, highly adhesive cell with abundant cytoplasm, an eccentric nucleus, and irregularly shaped pseuodopods. Contains azurophilic granules, vacuoles and phagosomes. histiocyte macrophage LMMA:00182 LMMA:00184 A partially differentiated fetal club cell, whose cytoplasm contains abundant glycogen granules. Full differentiation occurs postnatally when glycogen levels decrease and secretory granules increase. true immature Clara cell immature club cell LMMA:00184 CL:0000738 LMHA:00185 LMMA:00185 WBC leukocyte immune cell LMMA:00185 A pneumocyte with characteristics of both type I and type II precursor cells, identified by co-expression of SFTPC (a type II cell marker) and HOPX (a type I cell marker). LMMA:00187 bi-potential pneumocyte intermediate alveolar epithelial cell intermediate pneumocyte LMMA:00187 A mesenchymal-derived, connective tissue cell located in the interstitial space (i.e., interstitium or connective tissue compartments) of the lung. LMMA:00192 MES mesenchymal cell stromal cell interstitial cell LMMA:00192 Lipid-containing interstitial cell located in the alveolar septum (wall). The lipofibroblast transfers neutral lipid (tryglyceride) from the capillaries to the type II pneumocyte for the synthesis of surfactant phopholipids. It also synthesizes ECM proteins, such as collagen and elastin, and contains intermediate contractile filaments. LMHA:00209 LMMA:00209 true lipofibroblast LMMA:00209 LMMA:00213 A subset of lung macrophages which inhabit the interstitium where they interact with interstitial lymphocytes and help in mounting a specific immune response. They are CD45 pos, CD68 low, F4/80 low, CD11b+, Gr1-, CD11c low, CD14 low lung tissue macrophage pulmonary interstitial macrophage interstitial macrophage LMMA:00213 A mesenchymal-derived, squamous (flat), endothelial cell that lines the inner (i.e., luminal) surface of lymphatic vessels, forming a continuous, thin, endothelial cell layer or sheath (endothelium). CL:0002138 LMHA:00216 LMMA:00216 true lymphatic endothelial cell LMMA:00216 CL:0000542 LMHA:00223 LMMA:00223 Subtype of white blood cells including large lymphocytes (NK cells) and small lymphocytes (T cells, B cells, and plasma cells). lymphocyte LMMA:00223 CL:0000583 LMHA:00226 LMMA:00226 A tissue-resident macrophage found in the alveoli (lumen) of the lungs that is repsonsible for the clearance of inhaled particles, microorganisms, and pulmonary surfactant. Ingestion of small inhaled particles results in degradation and presentation of the antigen to immunocompetent cells. These cells are long-lived and self renewing. Marker profile: CD45 pos, CD68 high, F4/80 high, CD11b neg, CD11c high,MCHCII low, CD103 neg (1), CD64 pos and SiglecF high (2). true alveolar macrophage LMMA:00226 CL:0000097 LMHA:00227 LMMA:00227 A leukocyte that contains numerous basophilic granules, capable of releasing large amounts of histamine and heparin upon activation. Known for their role in allergy and anaphylaxis. mast cell LMMA:00227 A flat cell of mesenchymal origin that forms the superficial layer of the serosal membranes lining the body cavities of the abdomen and thorax. CL:0000077 LMHA:00231 LMMA:00231 true mesothelial cell LMMA:00231 CL:0000576 LMHA:00233 LMMA:00233 A bone marrow derived circulating, mononuclear leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. monocyte LMMA:00233 An epithelial cell that produces and secretes mucin, a substance containing mucopolysaacharides and protein, whch protects the epithelial cell surface. Mucous cells are found predominantely in the submucosal glands of the trachea and more rarely in the epithelum of the cartilaginous airways. LMHA:00238 MESH:D009077 LMMA:00238 true Mucous cell mucus cell LMMA:00238 CL:0000766 LMHA:00241 LMMA:00241 A cell of the monocyte, granulocyte, or mast cell lineage. myeloid leukocyte LMMA:00241 A contractile cell found between secretory cells and basement membrane of the seromucus glands located in the submucosa of the upper trachea in the mouse. Each myoepithelial cell has long cytoplasmic processes that wrap around a secretory unit (acinus, or smalll cluster of cells with a central lumen). The contraction of the myoepithelial processes forces the secretory product from the secretory unit into its duct. BTO:0002309 LMHA:00242 LMMA:00242 myoepithelial cell LMMA:00242 A stromal cell combining the features of a fibroblast and a smooth muscle cell, such as alpha-smooth-muscle-actin positive, contractile myofilaments BTO:0001946 LMHA:00243 LMMA:00243 true myofibroblast LMMA:00243 CL:0000623 LMHA:00245 LMMA:00245 A type of lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells large granular lymphocyte non-T, non-B lymphocyte natural killer cell LMMA:00245 An endocrine cell that produces and secretes neurotransmitters and neuropeptide hormones in response to neuronal signals. In the lung, these cells are found as single cells or in cell clusters (neuroepithelial bodies) and are located in the epithelium of the conducting airways, including trachea, bronchi, and bronchioles. CL:0000165 LMHA:00252 LMMA:00252 true neuroendocrine cell LMMA:00252 CL:0000775 LMHA:00256 LMMA:00256 A granular leukocyte that in its mature form contains a nucleus with 3-5 lobes containing fine inconspicuous granules stainable by neutral dyes in its cytoplasm. These granules contain anti-microbial substances that help combat infection when released by a process called degranulation neutrophil LMMA:00256 A supporting cell of the peripheral nervous system, derived from neural crest cells, which forms the insulating myelin sheaths of peripheral axons and is required for nerve maintenance and function. CL:0000218 LMHA:00338 LMMA:00338 Schwann cell neuroglial cell glial cell LMMA:00338 An epithelial cell that produces and secretes water, electrolytes, antimicrobial, anti-inflammatory, and antioxidant molecules, which protects the epithelial surrface. Serous cells are found predominantely in the submucosal glands of the trachea and more rarely in the epithelum of the cartilaginous airways. CL:0000313 LMHA:00340 LMMA:00340 serous cell LMMA:00340 A non-striated, elongated, spindle-shaped, involuntary contractile cell found in internal organs and blood vessels. Smooth muscle cells are found in the walls of the conducting airways (trachea, bronchi, bronchioles) and of the pulmonary and bronchial blood vessels (vascular smooth muscle). CL:0000192 LMHA:00343 LMMA:00343 true smooth muscle cell LMMA:00343 CL:0000084 LMHA:00354 LMMA:00354 A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex (specific cell-surface antigen receptors) T cell T Lymphocyte LMMA:00354 The telocyte is a type of fibroblast (interstitial/connective tissue cell) that has a small oval-shaped cell body with multiple (1-5), thin, elongated telopods (cytoplasmic extensions) that can be up to 100-microns long. These cells are C-KIT positive and are associated with morphogenesis and local tissue homeostasis. LMHA:00356 MESH:D000067170 LMMA:00356 telocyte LMMA:00356 A fibroblast found in the connective tissue layer located immediately under the vascular endothelium in the tunica intima of blood vessels. LMHA:00378 LMMA:00378 subendothelial connective tissue cell LMMA:00378 A thin, flat or squamous ("scale-like") alveolar epithelial cell, covering ~95% of the surface area of each alveolus, that facilitates gas exchange across the alveolar wall (septum), i.e., between the alveolus (airspace) and the capillary network. CL:0002062 LMHA:00379 LMMA:00379 true hypothetical, not published AEC1 AT1 cell ATI cell alveolar epithelial cell, type I alveolar type 1 cell alveolar type I cell alveolar type I epithelial cell lung type 1 cell pulmonary alveolar type I cell squamous alveolar cell squamous alveolar lining cell type I alveolar cell type I alveolar epithelial cell type I pneumocyte LMMA:00379 A fetal type I pneumocytes that is structurally immature. This former cuboidal-like cell changes shape to a flat, squamous-like cell, thinning and spreading over the luminal surface of the expanding terminal and/or primary alveolar saccule during late fetal lung development (E17.5 - E19.5). This process requires extensive membrane enlargement and reorganization of the cytoskeleton. LMMA:00380 AT1 precursor cell pre-type I pneumocyte type I progenitor cell type I pneumocyte precursor cell LMMA:00380 A cuboidal-like, alveolar epithelial cell that synthesizes, stores, secretes, and recycles pulmonary surfactant phospholipids and proteins, substances that reduce the surface tension in the alveolus. Pulmonary surfactant is stored in lipid-rich lamellar bodies, a distinctive feature of this cell type.. The type II pneumocyte is also capable of cell division and can repopulate the alveolar epitheium after injury, differentiating into type I pneumocytes. Although this cell type covers less than 5% of the alveolar surface, it represents 60% of all alveolar epithelial cells. CL:0002063 LMHA:00381 LMMA:00381 true hypothetical, not published AT2 cell ATII cell TII (type II) alveolar epithelial cell, type II alveolar epithelial type II cell alveolar type II cell cuboidal type II cell granular pneumocyte lung type 2 cell type 2 alveolar epithelial cell type 2 pneumocyte type II alveolar cell type II alveolar epithelial cell type II pneumocyte LMMA:00381 A fetal type II peumocyte that is structurally and biochemically immature. This cell is glycogen-rich with lamellar bodies in various stages of formation. Metabolically, large stores of glycogen are required to support surfactant lipid synthesis and lamellar body formation in this cell. LMMA:00382 AT2 precursor cell pre-type II pneumocyte type II progenitor cell type II pneumocyte precursor cell LMMA:00382 This term is used to describe an epithelial cell that cannot be classified under an existing epithelial cell type. LMHA:00384 LMMA:00384 general epithelial cell nonspecific epithelial cell this is included for general epithelial cell markers for imaging annotation unclassified epithelial cell LMMA:00384 This term is used to describe a fibroblast that cannot be classified under an existing fibroblast cell type. LMMA:00386 unclassified fibroblast LMMA:00386 An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. CL:0002139 LMHA:00392 LMMA:00392 true vascular endothelial cell LMMA:00392 CL:0002089 LMHA:00437 LMMA:00437 A innate lymphoid cell that plays an important role in type 2 immune responses to helminth worm infection and in conditions such as asthma and other atopic diseases. This cell secretes the type 2 cytokines, IL-4, -5, -9 and -13. nuocyte LMMA:00437 This term is used to describe an alveolar interstitial (stromal or connective tissue) cell that cannot be classified under an existing cell type. LMMA:00465 unclassified alveolar interstitial cell LMMA:00465 An epithelial cell that is located in the conducting airways of the fetal lung in the late pseudoglandular stage of lug development (E15.5-E16.5). This cell is committed to the ciliated cell lineage, but is not fully differentiated. It expresses FOXJ1, a marker for ciliated cells, but does not have fully formed, functional. motile cilia. LMMA:00476 true ciliated cell precusor LMMA:00476 LMMA:00477 This cell is found in the fetal lung and is defined by high levels of F4/80 and low levels of CD11b. true fetal macrophage primitive macrophage LMMA:00477 LMMA:00478 This cell is found in the fetal lung and is defined by high levels of Ly6C (a monocte marker) and high levels of CD11b true fetal monocyte LMMA:00478 A vascular endothelial cell that forms the endothelial lining of veins. LMMA:00507 true venous endothelial cell LMMA:00507 A neuron whose cell body is located within an autonomic ganglion, i.e., part of a cluster of nerve cell bodies in the peripheral nervous system. Each neuron consists of a body, an axon, and dendrites. Its purpose is to receive, conduct, and transmit impulses between the central nervous system and its target organs/tissues. CL:0000107 LMHA:00521 LMMA:00521 autonomic ganglion cell autonomic ganglion neuron autonomic neuron LMMA:00521 An epithelial cell found in the extrapulmonary conducting airways (tracheal and bronchial epithelia). This cell is a non-proliferative, TRP63-negative, MYB-positive, progenitor cell that can give rise to both ciliated and secretory cell types. It is distinct from basal cells, which are TRP63-positive, MYB-negative, and self-renewing. LMMA:00526 intermediate airway progenitor cell LMMA:00526 A cuboidal epithelial cell located in the distal acinar tubule, or bud, of the peripheral fetal lung in the pseudoglandular stage of lung development (E12.5-E16.5). These cells express cell-specific proteins (or markers) for pre-type II pneumocytes, such as surfactant protein C (SFTPC). LMMA:00572 Distal acinar epithelial cell distal acinar tubule epithelial cell LMMA:00572 A cuboidal epithelial cell that lines the proximal acinar tubule of the peripheral fetal lung in the pseudoglandular stage of lung development (E12.5 - E16.5). These cells express cell-specific proteins (or markers) for pre-type I pneumocytes, such as HOPX. LMMA:00573 proximal acinar epithelial cell proximal acinar tubule epithelial cell LMMA:00573 An epithelial cell that lines the peripheral gas exchange region (epithelial lining of the alveolar duct and alveoli) of the lungs. Includes both alveolar type I and type II pneumocytes. FMA:62499 LMHA:00586 LMMA:00574 alveolar epithelial cell LMMA:00574 An epithelial cell that lines the terminal saccule of the peripheral lung in the saccular stage of lung development (E18.5 - P0). The terminal saccule is an epithelial-lined, pre-alveolar structure with an immature, double capillary network in its septum (wall). At E18.5, it can be distinguished from the transitory duct by its relative location (distal), morphology (low cuboidal-like epithelium with more closely space nuclei), and immunohistochemical and/or immunofluorescence marker analysis. LMMA:00576 terminal saccule epithelial cell LMMA:00576 An epithelial cell that lines the intrapulmonary conducting airway, or bronchioles. The more proximal bronchioles are lined predominantly by ciliated cells with a greater proportion of club cells in the distal bronchioles. LMMA:00582 bronchiolar epithelial cell LMMA:00582 A mesenchymal-derived, connective tissue cell located in the interstitial space (interstitium or connective tissue compartment) between the pre-alveolar saccules of the peripheral lung in the saccular stage of lung development (E18.5 - P05). LMMA:00587 interstitial tissue cell pre-alveolar saccule mesenchymal cell pre-alveolar saccule stromal cell pre-alveolar saccule interstitial cell LMMA:00587 An epithelial cell that lines the trachea. The trachea is lined by pseudostratified columnar epithelial cells, including ciliated cells, club cells, basal cells, and neuroepithelial cells. CL:0000307 LMHA:00583 LMMA:00590 tracheal epithelial cell LMMA:00590 An epithelial cell that lines the bronchus. Bronchi are lined by pseudostratified columnar epithelial cells, including ciliated cells, club cells, basal cells, and neuroepithelial cells. CL:0002328 LMHA:00577 LMMA:00591 bronchial epithelial cell LMMA:00591 LMMA:00596 cell type LMMA:00596 A connective tissue (interstitial or stromal) cell that is undergoing cell division and can be distinguished by dual immunostaining for cell cycle markers and specific interstitial cell markers. LMMA:00598 proliferating interstitial cell proliferative interstitial cell LMMA:00598 LMMA:00599 proliferating epithelial cell proliferative epithelial cell LMMA:00599 LMMA:00607 true proliferative fibroblast LMMA:00607 LMMA:00609 This cell is found in the perinatal lung and is CD11b+,F4/80+ with intermediate levels of CD11c and CD64 and low levels of SiglecF true fetal macrophage immature alveolar macrophage immature macrophage LMMA:00609 LMMA:00612 true transitory duct epithelial cell LMMA:00612 BTO:0001096 LMHA:00614 LMMA:00614 Cells derived from stem cells of the lymphoid lineage. Responsible for the production of immunity mediated by cells or antibodies true lymphoid cell LMMA:00614 LMMA:00616 true arterial endothelial cell LMMA:00616 LMMA:00618 A immature or mature cell in the lineage leading to and including erythrocytes erythroid cell LMMA:00618 CL:0000232 LMHA:00622 LMMA:00619 A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. RBC red blood cell erythrocyte LMMA:00619 CL:0001065 LMHA:00623 LMMA:00620 A cell of the lymphoid lineage that lacks expression of rearranged antigen-specific receptors, existing mainly in non-lymphoid tissues as tissue-resident cells. These cells have physiological functions analogous to helper T cells, while also including the cytotoxic NK cells. They can be divided into 3 groups based on the cytokines they produce: Group 1 (ILC and NK cells) produces type 1 cytokines (IFNgamma and TNF); Group 2 (nuocytes) produces type 2 cytokines (IL-4, -5, -9, and -13); and Group 3 (ILC3 and lymphoid tissue-inducer cells) produces IL-17A and/or IL-22. They play an important role in protective immunity and in the regulation of homeostasis and inflammation. Dysregulation can result in allergic responses (asthma) and autoimmune disease. innate lymphoid cell LMMA:00620 LMMA:00627 true muscle cell LMMA:00627 LMMA:00655 proliferative smooth muscle cell LMMA:00655 LMMA:00671 proliferative cell LMMA:00671 BTO:0000392 CL:0000786 FMA:70574 LMHA:00574 LMMA:00677 plasma cell LMMA:00677 LMMA:00685 reticular cell LMMA:00685 CL:0000081 LMHA:00692 LMMA:00692 blood cell LMMA:00692 LMMA:00693 submucosal gland duct epithelial cell LMMA:00693 LMMA:00694 submucosal gland epithelial cell LMMA:00694 CL:0000868 LMHA:00681 LMMA:00698 mucosa-associated lymphoid tissue macrophage LMMA:00698 LMMA:00701 mesenchymal derived cell LMMA:00701 Cell Ontology for Mouse Lung Maturation Gail H. Deutsch Huaqin Pan NHLBI Molecular Atlas of Lung Development Program Consortium Ontology Subcommittee Susan E Wert