License Policy is in compliance with Creative Commons http://creativecommons.org/licenses/by/3.0/ MCBCC_0000001:FluidsAndSecretions Liquid substances produced by living organisms to fulfill specific functions or excreted as waste. MCBCC_0000002:BodyFluids Liquid components of living organisms. Ascitic_Fluids Effusion,_Peritoneal Effusions,_Peritoneal Fluid,_Ascitic Fluid,_Peritoneal Fluids,_Ascitic Fluids,_Peritoneal Peritoneal_Effusion Peritoneal_Effusions Peritoneal_Fluid Peritoneal_Fluids MCBCC_0000003:AsciticFluid The serous fluid of ascites, the accumulation of fluids in the peritoneal cavity. Chylopericardium Chylopericardiums Effusion,_Pericardial Effusions,_Pericardial Hemopericardium Pericardial_Effusions MCBCC_0000004:PericardialEffusion Fluid accumulation within the pericardium. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of thorasic duct. Severe cases can lead to cardiac tamponade. Effusion,_Pleural Effusions,_Pleural Pleural_Effusions MCBCC_0000005:PleuralEffusion Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself. MCBCC_0000006:BioMolecule A biomolecule is any organic molecule that is produced by a living organism, including large polymeric molecules such as proteins, polysaccharides, and nucleic acids as well as small molecules such as primary metabolites, secondary metabolites, and natural products. MCBCC_0000007:BacterialToxin A bacterial toxin is a type of toxin that is generated by bacteria. MCBCC_0000008:Cholera_Endotoxin MCBCC_0000009:Hormone Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects. MCBCC_0000010:AdrenalCortexHormone Hormones secreted from Adrenal cortex. MCBCC_0000011:Glucocorticoids MCBCC_0000012:PancreaticHormone Hormones secreted from Pancreas MCBCC_0000013:Proinsulin A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the pancreatic beta cells, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts. MCBCC_0000014:Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (glycogenolysis; gluconeogenesis) and indirectly by suppressing glucagon secretion and lipolysis. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (Diabetes mellitus, type 1) MCBCC_0000015:Protein Linear polypeptides that are synthesized on ribosomes and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of amino acids determines the shape the polypeptide will take, during protein folding, and the function of the protein. AIS Androgen_receptor DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM dihydrotestosterone_receptor MCBCC_0000016:AR The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. BRCA1/BRCA2-containing_complex,_subunit_1 BRCAI BRCC1 BROVCA1 IRIS PSCP RING_finger_protein_53 RNF53 breast_and_ovarian_cancer_susceptibility_protein_1 breast_and_ovarian_cancer_sususceptibility_protein breast_cancer_1,_early_onset MCBCC_0000017:BRCA1 This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. CRT CTR CTR1 calcitonin receptor MCBCC_0000018:CALCR This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. B-cell CLL/lymphoma 1 BCL1 CCND1 D11S287E G1/S-specific cyclin D1 PRAD1 U21B31 cyclin D1 MCBCC_0000019:CCND1 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. CD44 antigen CDW44 antigen GP90 lymphocyte homing/adhesion receptor Hermes antigen antigen gp90 homing receptor cell adhesion molecule cell surface glycoprotein CD44 chondroitin sulfate proteoglycan 8 extracellular matrix receptor-III hematopoietic cell E- and L-selectin ligand heparan sulfate proteoglycan homing function and Indian blood group system hyaluronate receptor phagocytic glycoprotein I MCBCC_0000020:CD44 The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. MCBCC_0000021:CDC4 Arc-1 CD324 CDH1 CDHE ECAD LCAM UVO cadherin 1, type 1, E-cadherin (epithelial) MCBCC_0000022:CDH1 CMD1I CSM1 CSM2 FLJ12025 FLJ39719 FLJ41013 FLJ41793 desmin intermediate filament protein MCBCC_0000023:DES This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. HOMG4 URG beta-urogastrone epidermal growth factor MCBCC_0000024:EGF Epidermal growth factor has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. ERBB ERBB1 HER1 PIG61 avian erythroblastic leukemia viral oncogene homolog cell growth inhibiting protein 40 cell proliferation-inducing protein 61 epidermal growth factor receptor mENA MCBCC_0000025:EGFR The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. CO-17A CO17-1A EGP EGP-2 EGP34 EGP40 ESA Ep-CAM GA733-2 KS1/4 KSA M4S1 MIC18 MK-1 TACST-1 TACSTD1 TROP1 adenocarcinoma-associated antigen carcinoma-associated antigen GA733-2 epithelial cell adhesion molecule epithelial glycoprotein-2 hEGP-2 membrane component, chromosome 4, surface marker tumor-associated calcium signal transducer 1 MCBCC_0000026:EPCAM This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. CD340 HER-2 HER-2/neu HER2 NEU NGL TKR1 c-erb B2/neu protein erbB-2 herstatin neuroblastoma/glioblastoma derived oncogene homolog v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 MCBCC_0000027:ERBB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. ErbB-3 HER3 LCCS2 MDA-BF-1 MGC88033 c-erbB-3 c-erbB3 erbB-3 erbB3-S p180-ErbB3 p45-sErbB3 p85-sErbB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 MCBCC_0000028:ERBB3 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. HER4 MGC138404 avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 p180erbB4 receptor tyrosine-protein kinase erbB-4 tyrosine kinase-type cell surface receptor HER4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 MCBCC_0000029:ERBB4 This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. DKFZp686N23123 ESRA Era NR3A1 estrogen receptor 1 estrogen receptor alpha MCBCC_0000030:ESR1 This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. ER ESR Estradiol receptor MCBCC_0000031:Estrogen_receptor Estrogen receptor is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. AGO CDC4 DKFZp686F23254 F-box and WD repeat domain containing 7 F-box and WD-40 domain protein 7 F-box protein FBW7 F-box protein SEL-10 FBW6 FBW7 FBX30 FBXO30 FBXW6 FLJ16457 SEL-10 SEL10 archipelago homolog archipelago, Drosophila, homolog of homolog of C elegans sel-10 MCBCC_0000032:FBXW7 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene. BFGFR CD331 CEK FGFBR FLG FLJ99988 FLT2 FMS-like tyrosine kinase 2 HBGFR KAL2 N-SAM OGD OTTHUMP00000190881 basic fibroblast growth factor receptor 1 fibroblast growth factor receptor 1 fms-related tyrosine kinase 2 heparin-binding growth factor receptor hydroxyaryl-protein kinase soluble FGFR1 variant 1 soluble FGFR1 variant 2 MCBCC_0000033:FGFR1 The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. BEK BEK fibroblast growth factor receptor BFR-1 CD332 CEK3 CFD1 ECT1 FLJ98662; JWS K-SAM KGFR OTTHUMP00000020624 OTTHUMP00000020626 TK14 TK25 bacteria-expressed kinase fibroblast growth factor receptor 2 hydroxyaryl-protein kinase keratinocyte growth factor receptor protein tyrosine kinase, receptor like 14 soluble FGFR4 variant 4 MCBCC_0000034:FGFR2 The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. FGF receptor FGFR MCBCC_0000035:FGF_receptors The fibroblast growth factor receptors consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. These receptors bind fibroblast growth factors, members of the largest family of growth factor ligands, comprising 22 members. So far, five distinct membrane FGFR have been identified in vertebrates and all of them belong to the tyrosine kinase superfamily (FGFR1 to FGFR4). AP3A hydrolase AP3Aase FRA3B bis(5'-adenosyl)-triphosphatase diadenosine 5',5'''-P1,P3-triphosphate hydrolase dinucleosidetriphosphatase fragile histidine triad gene tumor suppressor protein MCBCC_0000036:FHIT This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. FLJ45472 glial fibrillary acidic protein MCBCC_0000037:GFAP This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. ILPR IRDN insulin MCBCC_0000038:INS After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. CD220 HHF5 insulin receptor MCBCC_0000039:INSR After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. CK10 K10 KPP cytokeratin 10 keratin 10 MCBCC_0000040:KRT10 This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. CK13 K13 MGC161462 MGC3781 cytokeratin 13 keratin 13 keratin, type I cytoskeletal 13 MCBCC_0000041:KRT13 The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. CK14 EBS3 EBS4 K14 NFJ cytokeratin 14 keratin 14 MCBCC_0000042:KRT14 This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. CK16 FNEPPK K16 K1CP KRT16A; NEPPK cytokeratin 16 focal non-epidermolytic palmoplantar keratoderma keratin 16 keratin, type I cytoskeletal 16 MCBCC_0000043:KRT16 The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. K17 PC PC2 PCHC1 cytokeratin-17 keratin 17 MCBCC_0000044:KRT17 This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. CYK18 K18 cell proliferation-inducing protein 46 cytokeratin 18 keratin 18 MCBCC_0000045:KRT18 KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. 40-kDakeratinintermediatefilament CK19 K19 K1CS MGC15366 cytokeratin19 keratin,typeI,40-kd keratin,typeIcytoskeletal19 keratin19 MCBCC_0000046:KRT19 The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. CK4 CYK4 FLJ31692 K4 cytokeratin 4 keratin 4 keratin, type II cytoskeletal 4 MCBCC_0000047:KRT4 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. CK7 K2C7 K7 MGC129731; MGC3625 SCL cytokeratin 7 keratin 7 keratin, 55K type II cytoskeletal keratin, simple epithelial type I, K7 keratin, type II cytoskeletal 7 sarcolectin type II mesothelial keratin K7 MCBCC_0000048:KRT7 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. CARD2 CK8 CYK8 K2C8 K8 KO cytokeratin 8 keratin 8 keratin, type II cytoskeletal 8 MCBCC_0000049:KRT8 This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. CK6 KRT6 cytokeratin 6 MCBCC_0000050:Keratin_6 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. CD227 DF3 antigen EMA H23 antigen H23AG KL-6 MAM6 MUC-1/SEC MUC-1/X MUC1/ZD PEM PEMT PUM breast carcinoma-associated antigen DF3 episialin mucin 1, cell surface associated mucin 1, transmembrane peanut-reactive urinary mucin polymorphic epithelial mucin tumor associated epithelial mucin MCBCC_0000051:MUC1 This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. MLP SMUC mucin 2, intestinal/tracheal mucin 2, oligomeric mucus/gel-forming MCBCC_0000052:MUC2 This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. MRTL avian myelocytomatosis viral oncogene homolog bHLHe39 c-Myc myc proto-oncogene protein myc-related translation/localization regulatory factor v-myc avian myelocytomatosis viral oncogene homolog v-myc myelocytomatosis viral oncogene homolog MCBCC_0000053:MYC The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. MUC3 mucin 3 mucin 3, intestinal MCBCC_0000054:Mucin_3 The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation. GR-A glucocorticoid receptor alpha nuclear receptor subfamily 3, group C, member 1 MCBCC_0000055:NR3C1 Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation. ARIA GGF GGF2 HGL HRG HRG1 HRGA NDF SMDF glial growth factor heregulin, alpha (45kD, ERBB2 p185-activator) neu differentiation factor neuregulin 1 sensory and motor neuron derived factor MCBCC_0000056:NRG1 The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). NR3C3 PR progesterone receptor MCBCC_0000057:PGR This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined. 10q23del BZS MGC11227 MHAM MMAC1 MMAC1 phosphatase and tensin homolog deleted on chromosome 10 PTEN1 TEP1 mutated in multiple advanced cancers 1 phosphatase and tensin homolog MCBCC_0000058:PTEN This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. ABCB MDR PGP MCBCC_0000059:P_glycoprotein P-glycoprotein is a well-characterized ABC-transporter of the MDR/TAP subfamily. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. DKFZp686K18126 FLJ42304 Ga55 KIAA1103 gastric cancer antigen Ga55 taxin 1 transforming, acidic coiled-coil containing protein 1 MCBCC_0000060:TACC1 This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. DPD1 ED LAP TGF-beta 1 protein TGFB TGFbeta diaphyseal dysplasia 1, progressive latency-associated peptide transforming growth factor, beta 1 MCBCC_0000061:TGFB1 This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. AAT5 ACVRLK4 ALK-5 ALK5 LDS1A LDS2A SKR4 TGFR-1 activin A receptor type II-like kinase, 53kD activin A receptor type II-like kinase, 53kDa activin receptor-like kinase 5 serine/threonine-protein kinase receptor R4 transforming growth factor beta receptor I transforming growth factor, beta receptor 1 transforming growth factor, beta receptor I transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) MCBCC_0000062:TGFBR1 The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. AAT3 FAA3 LDS1B LDS2B MFS2 RIIC TAAD2 TGF-beta receptor type IIB TGF-beta type II receptor TGFR-2 TGFbeta-RII transforming growth factor beta receptor type IIC transforming growth factor, beta receptor II MCBCC_0000063:TGFBR2 This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. APC1 protein DIF TNF superfamily, member 2 TNF, macrophage-derived TNF, monocyte-derived TNF-alpha TNFA TNFSF2 cachectin tumor necrosis factor tumor necrosis factor alpha MCBCC_0000064:TNF This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. FLJ92943 LFS1 TRP53 p53 p53 antigen p53 transformation suppressor p53 tumor suppressor phosphoprotein p53 transformation-related protein 53 tumor protein p53 MCBCC_0000065:TP53 This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. FLJ36605 vimentin MCBCC_0000066:VIM This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract. INT4 MGC131950 MGC138321 MGC138323 WNT-3 proto-oncogene protein wingless-type MMTV integration site family, member 3 MCBCC_0000067:WNT3 The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. WNT-5A protein hWNT5A wingless-type MMTV integration site family, member 5A MCBCC_0000068:WNT5A The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98%, 98% and 87% amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction. wingless-type MMTV integration site family, member 7B MCBCC_0000069:WNT7B This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. MCBCC_0000070:CellLine MCBCC_0000071:NormalCellLine MCBCC_0000072:NormalHumanCellLine 184-A1 184_A1 CRL-8798 MCBCC_0000074:A1 184-A1N4 184_A1N4 184_A_1_N_4 MCBCC_0000075:A1N4 184-B5 184_B5 CRL-8799 MCBCC_0000076:B5 184htert MCBCC_0000077:htrt HBL-100 HBL_100 MCBCC_0000078:HBL100 MCBCC_0000079:HMEC CRL-7145 Hs190.T MCBCC_0000080:Hs_190.T CRL-7242 Hs329.T MCBCC_0000081:Hs_329.T CRL-7246 Hs344.T MCBCC_0000082:Hs_344.T CRL-7248 Hs350.T MCBCC_0000083:Hs_350.T CRL-7256 Hs371.T MCBCC_0000084:Hs_371.T HTB-125 HS578BST MCBCC_0000085:Hs_578Bst CRL-7347 Hs579.Mg MCBCC_0000086:Hs_579.Mg CRL-7379 Hs617.Mg MCBCC_0000087:Hs_617.Mg CRL-7574 Hs841.T MCBCC_0000088:Hs_841.T CRL-7583 Hs849.T MCBCC_0000089:Hs_849.T CRL-7584 Hs851.T MCBCC_0000090:Hs_851.T CRL-7612 Hs875.T MCBCC_0000091:Hs_875.T MCBCC_0000092:M566 MCF10A-Myc c-Myc-MCF10A MCBCC_0000093:MCF10AMyc MCF10A cells (human mammary epithelial cells) stably expressing c-Myc. CRL-10317 MCF-10A MCBCC_0000094:MCF_10A ECACC-94122105 MCBCC_0000095:SVCT 98031102 MCBCC_0000096:fR2 98031103 MCBCC_0000097:fR5 ME16C hTERTHME1 CRL-4010 MCBCC_0000098:hTERT-HME1 Human non cancer breast epithelial cells immortalized by infection with the retrovirus pBabepuro+hTERT vectorline MCBCC_0000099:PathologicalCellLine MCBCC_0000100:PathologicalHumanCellLine CRL-7329 Hs564(E).Mg E:Mg CRL-7336 Hs566(B).T B:T MPE-600 MPE600 MPE_600 MCBCC_0000103:MPE AU-565 AU_565 CRL-2351 MCBCC_0000104:AU565 BCAP-37 MCBCC_0000105:BCAP37 BRC 230 BRC230 MCBCC_0000106:BRC-230 BT-20 BT_20 HTB-19 MCBCC_0000107:BT-20 BT-474 BT_474 HTB-20 ACC 64 ICLC_HTL00008 MCBCC_0000108:BT-474 BT-483 BT_483 HTB-121 MCBCC_0000109:BT-483 BT-549 BT_549 HTB-122 ICLC HTL02006 MCBCC_0000110:BT-549 CAL120 MCBCC_0000111:CAL-120 ACC 460 CAL148 MCBCC_0000112:CAL-148 CAL51 MCBCC_0000113:CAL-51 CAL851 MCBCC_0000114:CAL-85-1 CAMA-1 CAMA_1 HTB-21 MCBCC_0000115:CAMA-1 COLO824 MCBCC_0000116:COLO-824 DU-4475 DU_4475 HTB-123 MCBCC_0000117:DU4475 ACC 231 EFM19 MCBCC_0000118:EFM-19 ACC 258 EFM192A MCBCC_0000119:EFM-192A ACC 308 EFM192B MCBCC_0000120:EFM-192B ACC 311 EFM192C MCBCC_0000121:EFM-192C MCBCC_0000122:EVSA-T GI101A MCBCC_0000123:GI-101A MCBCC_0000124:H3922 MCBCC_0000125:HCC1007 HCC-1008 HCC_1008 CRL-2320 MCBCC_0000126:HCC1008 HCC-1143 HCC_1143 CRL-2321 MCBCC_0000127:HCC1143 HCC-1187 HCC_1187 CRL-2322 MCBCC_0000128:HCC1187 HCC-1395 HCC_1395 CRL-2324 MCBCC_0000129:HCC1395 HCC-1419 HCC_1419 CRL-2326 MCBCC_0000130:HCC1419 HCC-1428 HCC_1428 CRL-2327 MCBCC_0000131:HCC1428 HCC-1500 HCC_1500 CRL-2329 MCBCC_0000132:HCC1500 HCC-1569 HCC_1569 CRL-2330 MCBCC_0000133:HCC1569 HCC-1599 HCC_1599 CRL-2331 MCBCC_0000134:HCC1599 HCC-1739 HCC_1739 MCBCC_0000135:HCC1739 HCC-1806 HCC_1806 CRL-2335 MCBCC_0000136:HCC1806 HCC-1937 HCC_1937 CRL-2336 MCBCC_0000137:HCC1937 HCC-1954 HCC_1954 CRL-2338 MCBCC_0000138:HCC1954 HCC-202 HCC_202 CRL-2316 MCBCC_0000139:HCC202 HCC-2157 HCC_2157 CRL-2340 MCBCC_0000140:HCC2157 HCC-2185 HCC_2185 MCBCC_0000141:HCC2185 HCC-2218 HCC_2218 CRL-2343 MCBCC_0000142:HCC2218 HCC_3153 MCBCC_0000143:HCC3153 CRL-2314 HCC_38 MCBCC_0000144:HCC38 CRL-2315 HCC_70 MCBCC_0000145:HCC70 HCC_712 MCBCC_0000146:HCC712 ACC 494 HDQP1 MCBCC_0000147:HDQ-P1 HMT 3909 HMT3909 MCBCC_0000148:HMT-3909 Hs-274.T Hs274.T CRL-7222 MCBCC_0000149:Hs_274.T Hs-281.T Hs281.T CRL-7227 MCBCC_0000150:Hs_281.T Hs-319.T Hs319.T CRL-7236 MCBCC_0000151:Hs_319.T Hs-343.T Hs343.T CRL-7245 MCBCC_0000152:Hs_343.T Hs-362.T Hs362.T CRL-7253 MCBCC_0000153:Hs_362.T Hs-574.T Hs574.T CRL-7345 MCBCC_0000154:Hs_574.T HTB-126 Hs-578T MCBCC_0000155:Hs_578T Hs-605.T Hs605.T CRL-7365 MCBCC_0000156:Hs_605.T Hs-606.T Hs606.T CRL-7368 MCBCC_0000157:Hs_606.T Hs-739.T Hs739.T CRL-7477 MCBCC_0000158:Hs_739.T Hs-741.T Hs741.T CRL-7480 MCBCC_0000159:Hs_741.T Hs-742.T Hs742.T CRL-7482 MCBCC_0000160:Hs_742.T Hs-748.T Hs748.T CRL-7486 MCBCC_0000161:Hs_748.T Hs-861.T Hs861.T CRL-7596 MCBCC_0000162:Hs_861.T IBEP2 MCBCC_0000163:IBEP-2 IBH6 MCBCC_0000164:IBH-6 IBH7 MCBCC_0000165:IBH-7 JIMT1 JIMT_1 ACC 589 MCBCC_0000166:JIMT-1 KPL1 MCBCC_0000167:KPL-1 LY-2 MCBCC_0000168:LY2 CRL-2914 MCBCC_0000169:M4A4 CRL-2915 MCBCC_0000170:M4A4_GFP CRL-2916 MCBCC_0000171:M4A4_LM3-2_GFP CRL-2917 MCBCC_0000172:M4A4_LM3-4_CL16_GFP MCBCC_0000173:M7TS90 MB-157 MB157 CRL-7721 MCBCC_0000174:MB_157 CRL-10781 MCF10-2A MCBCC_0000175:MCF-10-2A CRL-10782 MCF-12A MCBCC_0000176:MCF-12A CRL-10783 MCF12F MCBCC_0000177:MCF-12F MCF-7/TAMR-1 MCBCC_0000178:MCF-7_Tam1 MCBCC_0000179:MCF10CA1 MCBCC_0000180:MCF10CA1a Ca1h MCBCC_0000181:MCF10CA1h MCBCC_0000182:MCF10DCIS.com HTB-22 MCF-7 MCF7-MVLN MCBCC_0000183:MCF7 ICLC HTL95018 MCBCC_0000184:MCF7-382 ICLC HTL95017 MCBCC_0000185:MCF7-422 ICLC HTL95019 MCBCC_0000186:MCF7-432 ICLC HTL96004 MCF7488X1 MCBCC_0000187:MCF7-488X1 ICLC HTL96002 MCF7490X1 MCBCC_0000188:MCF7-490X1 ICLC HTL96028 MCF7492X1 MCBCC_0000189:MCF7-492X1 MCF-7:2A MCF72:a MCF75:LCC1 MCF74:LCC2 LCC-9 MCF7:LCC9 MCF73:WS8 HER2-18 MCF-7/Her2-18 MCF7/HER2-18 MCBCC_0000195:MCF7_Her2-18 MCF7A/Z MCF7A:Z MCF-7/Adr MCBCC_0000197:MCF7ADR MCF-7_early_passage MCF7E MCBCC_0000198:MCF7E MCBCC_0000199:MCF7IMIII MCF-7_late_passage MCF7L MCBCC_0000200:MCF7L MCBCC_0000201:MCF7mp53 CRL-10318 MCF_10F MCBCC_0000202:MCF_10F MDA_kb2 MDAkb2 CRL-2713 MCBCC_0000203:MDA-kb2 MDAMB134VI MDA_MB_134_VI HTB-23 MCBCC_0000204:MDA-MB-134-VI MDAMB157 MDA_MB_157 HTB-24 MCBCC_0000205:MDA-MB-157 MDAMB175VII MDA_MB_175_VII HTB-25 MCBCC_0000206:MDA-MB-175-VII MDAMB231 MDA_MB_231 HTB-26 MCBCC_0000207:MDA-MB-231 MDA-231-D MCBCC_0000208:MDA-MB-231-5a-D MDA-5a MCBCC_0000209:MDA-MB-231-5a MDAMB330 MDA_MB_330 HTB-127 MCBCC_0000210:MDA-MB-330 MDAMB361 MDA_MB_361 HTB-27 MCBCC_0000211:MDA-MB-361 MDAMB415 MDA_MB_415 HTB-128 MCBCC_0000212:MDA-MB-415 MDAMB436 MDA_MB_436 HTB-130 MCBCC_0000213:MDA-MB-436 MDAMB453 MDA_MB_453 HTB-131 MCBCC_0000214:MDA-MB-453 MDAMB468 MDA_MB_468 HTB-132 MCBCC_0000215:MDA-MB-468 MDA468/NQ16 MDA468_NQ16 NQ16 MCBCC_0000216:MDA468_Clone_NQ16 ACC 422 MFM223 MCBCC_0000217:MFM-223 ACC 403 MT3 MCBCC_0000218:MT-3 MCBCC_0000219:MVLN MCBCC_0000220:MX-1 CRL-2918 MCBCC_0000221:NM2C5 CRL-2919 MCBCC_0000222:NM2C5_GFP MCBCC_0000223:OCUB-F SKBR3 SK_BR_3 HTB-30 ICLC HTL03005 MCBCC_0000224:SK-BR-3 SKBR5 SK_BR_5 MCBCC_0000225:SK-BR-5 SKBR7 SK_BR_7 MCBCC_0000226:SK-BR-7 SUM-102PT MCBCC_0000227:SUM102PT SUM-1315MO2 MCBCC_0000228:SUM1315MO2 SUM-149 SUM-149PT MCBCC_0000229:SUM149PT SUM-159PT MCBCC_0000230:SUM159PT SUM-185PE MCBCC_0000231:SUM185PE SUM-190PT MCBCC_0000232:SUM190PT SUM-225CWN MCBCC_0000233:SUM225CWN SUM-229PE MCBCC_0000234:SUM229PE SUM-44PE MCBCC_0000235:SUM44PE SUM-52PE SUM52 MCBCC_0000236:SUM52PE SW-527 SW_527 CRL-7940 MCBCC_0000237:SW527 HTB-133 85102201 ICLC HTL98003 T47D MCBCC_0000238:T-47D CRL-2865 MCBCC_0000239:T47D-KBluc T-47D/A1-2 T47D(A1-2) T47D:A1-2 MCBCC_0000241:TSE CRL-1897 UACC812 MCBCC_0000242:UACC-812 CRL-1902 UACC893 MCBCC_0000243:UACC-893 MCBCC_0000244:YMB-1 MCBCC_0000245:YMB-A MCBCC_0000246:YMB-S CRL-1500 87012601 ICLC HTL99006 ZR75-1 MCBCC_0000247:ZR-75-1 MCBCC_0000248:ZR-75-1_dox MCBCC_0000249:ZR-75-27 CRL-1504 88113004 ZR7530 MCBCC_0000250:ZR-75-30 MCBCC_0000251:ZR-75-9a1 MCBCC_0000252:ZR-PR-LT ZR-75-B MCBCC_0000253:ZR75B MCBCC_0000254:PathologicalMouseCellLine MCBCC_0000255:T1 The 4T1 cell line was derived from a spontaneously arising BALB/c mammary tumor MCBCC_0000256:ChemicalsAndDrugs MCBCC_0000257:HormoneAntagonists Inhibitors of hormonal activity MCBCC_0000258:Antiestrogens Inhibitors of estrogen hormone activity ICI 164,384 ICI M164384 N-n-Butyl-N-methyl-11-(3,17beta-dihydroxyestra-1,3,5(10)-trien-7alpha-yl)undecanamide MCBCC_0000259:ICI_164384 7alpha-(9-((4,4,5,5,5-Pentafluoropentyl)sulfinyl)nonyl)estra-1,3,5(10)-triene-3,17beta-diol CCRIS 8741 Faslodex Fulvestrant HSDB 7658 ICI 182,780 ICI 182780 UNII-22X328QOC4 ZM 182780 MCBCC_0000260:ICI_182780 MCBCC_0000261:Lipid A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. Acids, Aliphatic Acids, Esterified Fatty Acids, Fatty Acids, Saturated Fatty Aliphatic Acids Esterified Fatty Acids Fatty Acids, Esterified Fatty Acids, Saturated Saturated Fatty Acids MCBCC_0000262:FattyAcid Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated. EINECS 207-595-8 UNII-HU9DX48N0T MCBCC_0000263:Mycophenolic_acid MCBCC_0000264:OrganicChemicals A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form. MCBCC_0000265:Hydrocarbons Isoprenoids Terpenoids MCBCC_0000266:Terpenes A class of compounds composed of repeating 5-carbon units of hemiterpenes Carotene Carotenes MCBCC_0000267:Carotenoids The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons consisting of a polyisoprene backbone. MCBCC_0000268:Retinoids A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic acne; psoriasis; and other disorders of keratinization. 11-cis-Retinol 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer All Trans Retinol All-Trans-Retinol Aquasol A Retinol Vitamin A1 MCBCC_0000269:VitaminA Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of carotenoids found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. Acid, Retinoic Acid, Vitamin A Acid, all-trans-Retinoic Acid, beta-all-trans-Retinoic Acid, trans-Retinoic Potassium Salt, Tretinoin Retin A Retin-A Retinoic Acid Salt, Tretinoin Potassium Salt, Tretinoin Sodium Salt, Tretinoin Zinc Sodium Salt, Tretinoin Tretinoin Potassium Salt Tretinoin Sodium Salt Tretinoin Zinc Salt Vesanoid Vitamin A Acid Zinc Salt, Tretinoin all trans Retinoic Acid all-trans-Retinoic Acid beta all trans Retinoic Acid beta-all-trans-Retinoic Acid trans Retinoic Acid trans-Retinoic Acid MCBCC_0000270:Tretinoin An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). Cembrane Diterpenes Cembranes Diterpenes, Cembrane Diterpenes, Labdane Diterpenoids Labdane Diterpenes Labdanes Norditerpenes Norditerpenoids MCBCC_0000271:Diterpenes Twenty-carbon compounds derived from mavalonic acid or deoxyxylulose phosphate. MCBCC_0000272:Phorbols The parent alcohol of the tumor promoting compounds from croton oil (Croton tiglium). Diesters, Phorbol Esters, Phorbol Phorbol Diesters MCBCC_0000273:PhorbolEsters Tumor-promoting compounds obtained from croton oil (Croton tiglium). Some of these are used in cell biological experiments as activators of protein kinase C. 12 Myristoyl 13 acetylphorbol 12 O Tetradecanoyl Phorbol 13 Acetate 12-Myristoyl-13-acetylphorbol 12-O-Tetradecanoyl Phorbol 13-Acetate 13-Acetate, 12-O-Tetradecanoyl Phorbol Acetate, Phorbol Myristate Acetate, Tetradecanoylphorbol Myristate Acetate, Phorbol Phorbol 13-Acetate, 12-O-Tetradecanoyl Phorbol Myristate Acetate Tetradecanoylphorbol Acetate, 4a alpha Isomer Tetradecanoylphorbol Acetate, 4a alpha-Isomer MCBCC_0000274:TetradecanoylphorbolAcetate A phorbol ester found in croton oil with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA. MCBCC_0000275:ReceptorAntagonists Compounds inhibiting receptor activity MCBCC_0000276:ERBB2Inhibitors Compounds inhibitng ERBB2 receptor activity. MCBCC_0000277:TherapeuticAgent Compounds used in treatment of various pathological conditions. Agents, Anti-Bacterial Agents, Anti-Mycobacterial Agents, Antibacterial Agents, Antimycobacterial Agents, Bacteriocidal Anti Bacterial Agents Anti Mycobacterial Agents Anti-Mycobacterial Agents Antibacterial Agents Antibiotics Antimycobacterial Agents Bacteriocidal Agents Bacteriocides MCBCC_0000278:AntiBacterialAgents Substances that reduce the growth or reproduction of bacteria. Antibiotic G418 BRN 1669188 G 418 MCBCC_0000279:Geneticin (4-Oxo-5-(phenylmethoxy)-4H-pyran-2-yl)methyl thiocyanate 5-Benzyloxy-2-thiocyanatomethyl-4-pyranone 5-Bz-2-Scnm-4-pyranone Zeomycin MCBCC_0000280:Zeocin Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind and cleave DNA. MCBCC_0000281:AntineoplasticAgents Adriablastin Adriablastine Adriamycin Adriblastin Adriblastina Adriblastine Adrimedac Baxter Brand of Doxorubicin Hydrochloride Bristol-Myers Squibb Brand of Doxorubicin Hydrochloride Caelyx Columbia Brand of Doxorubicin Hydrochloride DOX SL DOX-SL DOXO cell DOXO-cell Doxil Doxolem Doxorubicin Hexal Doxorubicin Hydrochloride Doxorubicin NC Doxorubicin, Liposomal Doxorubicina Ferrer Farm Doxorubicina Funk Doxorubicina Tedec Doxorubicine Baxter Doxotec Elan Brand of Doxorubicin Hydrochloride Essex Brand of Doxorubicin Hydrochloride Farmiblastina Ferrer Brand of Doxorubicin Hydrochloride Hexal Brand of Doxorubicin Hydrochloride Hydrochloride, Doxorubicin Kenfarma Brand of Doxorubicin Hydrochloride Lemery Brand of Doxorubicin Hydrochloride Liposomal Doxorubicin Myocet Neocorp Brand of Doxorubicin Hydrochloride Onkodox Onkoworks Brand of Doxorubicin Hydrochloride Ortho Biotech Brand of Doxorubicin Hydrochloride Pharmacia Brand of Doxorubicin Hydrochloride Prasfarma Brand of Doxorubicin Hydrochloride Ribodoxo Rubex Schering Brand of Doxorubicin Hydrochloride Schering-Plough Brand of Doxorubicin Hydrochloride Tedec Meiji Brand of Doxorubicin Hydrochloride Urokit Doxo cell Urokit Doxo-cell cell pharm Brand of Doxorubicin Hydrochloride medac Brand of Doxorubicin Hydrochloride ribosepharm Brand of Doxorubicin Hydrochloride MCBCC_0000282:Doxorubicin Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of daunorubicin. 4' Epi Adriamycin 4' Epi DXR 4' Epi Doxorubicin 4' Epiadriamycin 4' Epidoxorubicin 4'-Epi-Adriamycin 4'-Epi-DXR 4'-Epi-Doxorubicin 4'-Epiadriamycin 4'-Epidoxorubicin EPI-cell Ellence Epilem Epirubicin Hydrochloride Farmorubicin Farmorubicina Farmorubicine Hydrochloride, Epirubicin IMI 28 IMI-28 IMI28 Kenfarma Brand of Epirubicin Hydrochloride Lemery Brand of Epirubicin Hydrochloride NSC 256942 NSC-256942 NSC256942 Pharmacia Brand of Epirubicin Hydrochloride Pharmorubicin cell pharm Brand of Epirubicin MCBCC_0000283:Epirubicin An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. Baxter Brand of Etoposide Baxter Oncology Brand of Etoposide Bristol Myers Brand of Etoposide Bristol Myers Squibb Brand of Etoposide Bristol-Myers Brand of Etoposide Bristol-Myers Squibb Brand of Etoposide Celltop Demethyl Epipodophyllotoxin Ethylidine Glucoside Eposide Eposin Eto CS Eto GRY Eto-GRY Etomedac Etopos Etoposide Pierre Fabre Etoposide Teva Etoposide, (5S)-Isomer Etoposide, (5a alpha)-Isomer Etoposide, (5a alpha,9 alpha)-Isomer Etoposide, alpha D Glucopyranosyl Isomer Etoposide, alpha-D-Glucopyranosyl Isomer Etoposido Ferrer Farma Exitop Ferrer Brand of Etoposide Gry Brand of Etoposide Lastet Lemery Brand of Etoposide Medac Brand of Etoposide NSC 141540 NSC-141540 NSC141540 Novartis Brand of Etoposide Onkoposid Onkoworks Brand of Etoposide Pharmachemie Brand of Etoposide Pharmacia Brand of Etoposide Pierre Fabre Brand of Etoposide Prasfarma Brand of Etoposide Riboposid Sanfer Brand of Etoposide Tedec Meiji Brand of Etoposide Teva Brand of Etoposide Toposar VP 16 VP 16 213 VP 16-213 VP 16213 VP-16 VP16 Vepesid Vépéside Sandoz Vépéside-Sandoz alpha-D-Glucopyranosyl Isomer Etoposide ribosepharm Brand of Etoposide MCBCC_0000284:Etoposide A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. 13-dihydroidarubicin 4-demethoxy-14-hydroxydaunorubicin idarubicinol, (7S-(7alpha,9alpha,9(S*)))-isomer MCBCC_0000285:Idarubicinol AHP Brand of Mitoxantrone Hydrochloride ASTA Medica Brand of Mitoxantrone Hydrochloride Acetate, Mitoxantrone Amgen Brand of Mitoxantrone Hydrochloride Baxter Oncology Brand of Mitoxantrone Hydrochloride CL 232325 CL-232325 CL232325 Columbia Brand of Mitoxantrone Hydrochloride DHAQ Hydrochloride, Mitoxantrone Inibsa Brand of Mitoxantrone Hydrochloride Lederle Brand of Mitoxantrone Hydrochloride Mitoxantrone Acetate Mitoxantrone Hydrochloride Mitozantrone Mitroxone NSC 279836 NSC 287836 NSC 299195 NSC 301739 NSC 301739D NSC-279836 NSC-287836 NSC-299195 NSC-301739 NSC-301739D NSC279836 NSC287836 NSC299195 NSC301739 NSC301739D Novantron Novantrone Onkotrone Pralifan Ralenova Wyeth Brand of Mitoxantrone Hydrochloride MCBCC_0000286:Mitoxantrone An anthracenedione-derived antineoplastic agent. MCBCC_0000287:GeneticVariation MCBCC_0000288:ChromosomalMutation MCBCC_0000289:ChromosomalDeletion MCBCC_0000290:Deletion_in_long_arm MCBCC_0000291:Deletion_in_shortarm MCBCC_0000292:Homozygous_deletion_at_3p12 MCBCC_0000293:Homozygous_deletion_at_3p14.2 MCBCC_0000294:Homozygous_deletion_at_3p21.3 MCBCC_0000295:GeneMutation MCBCC_0000296:Deletion MCBCC_0000297:ExonDeletion MCBCC_0000298:Exon2_deletion_CDH1 MCBCC_0000299:Exon5_deletion_EstrogenReceptor MCBCC_0000300:Exon9_deletion_CDH1 MCBCC_0000301:HomozygousDeletion_FHITgene MCBCC_0000302:HomozygousDeletion_PTENgene MCBCC_0000303:Duplication MCBCC_0000304:ExonDuplication MCBCC_0000305:Exon8_duplication_CDC4 MCBCC_0000306:Exon9_duplication_CDC4 MCBCC_0000307:GeneDuplication MCBCC_0000308:CCND1_GeneAmplification MCBCC_0000309:ERBB2_GeneAmplification MCBCC_0000310:FGFR1_GeneAmplification MCBCC_0000311:FGFR2_GeneAmplification MCBCC_0000312:MYC_GeneAmplification MCBCC_0000313:TACC1_GeneAmplification MCBCC_0000314:Insertion MCBCC_0000315:insC_BRCA1 MCBCC_0000316:ins10bp_BRCA1 MCBCC_0000317:PointMutation MCBCC_0000318:NonsenseMutation MCBCC_0000319:Exon10_Codon342_StopCodon_TP53 MCBCC_0000320:Exon5_Codon_166_StopCodon_TP53 MCBCC_0000321:Exon6_Codon213_StopCodon_TP53 MCBCC_0000322:Exon8_Codon266_StopCodon_TP53 MCBCC_0000323:Exon8_Codon294_StopCodon_TP53 MCBCC_0000324:Exon8_Codon306_StopCodon_TP53 MCBCC_0000325:Transition MCBCC_0000326:Exon5_Codon175_CGCtoCAC_TP53 MCBCC_0000327:Exon6_Codon194_CTTtoTTT_TP53 MCBCC_0000328:Exon7_Codon248_CGGtoCAG_TP53 MCBCC_0000329:Exon7_Codon249_AGGtoGGG_TP53 MCBCC_0000330:Exon8_Codon273_CGTtoCAT_TP53 MCBCC_0000331:Exon8_Codon280_AGAtoAAA_TP53 MCBCC_0000332:Exon8_Codon283_CGCtoTGC_TP53 MCBCC_0000333:Exon8_Codon285_GAGtoAAG_TP53 MCBCC_0000334:Transversion MCBCC_0000335:Exon5_Codon132_AAGtoCAG_TP53 MCBCC_0000336:Exon5_Codon157_GTCtoTTC_TP53 MCBCC_0000337:Exon7_Codon249_AGGtoAGC_TP53 MCBCC_0000338:Exon8_Codon273_CGTtoCTT_TP53 MCBCC_0000339:Exon8_Codon280_AGAtoACA_TP53 MCBCC_0000340:Exon8_Codon281_GACtoCAC_TP53 MCBCC_0000341:Nucleotide651_GtoT_FHIT MCBCC_0000342:PathologicalCondition Benign Neoplasm Benign Neoplasms Cancer Cancers Neoplasm Neoplasm, Benign Neoplasms, Benign Tumor Tumors MCBCC_0000343:Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. MCBCC_0000344:PapillaryInvasiveDuctalTumor Invasive form of papillary ductal cercinoma of the breast. MCBCC_0000345:NonInvasiveBreastCarcinoma Benign tumors of the breast. Carcinoma, Intraductal Carcinoma, Intraductal, Noninfiltrating Carcinoma, Noninfiltrating Intraductal Carcinomas, Intraductal Carcinomas, Noninfiltrating Intraductal DCIS Intraductal Carcinoma Intraductal Carcinoma, Noninfiltrating Intraductal Carcinomas Intraductal Carcinomas, Noninfiltrating Noninfiltrating Intraductal Carcinoma Noninfiltrating Intraductal Carcinomas MCBCC_0000346:DuctalCarcinomaInSitu A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma. MCBCC_0000347:LobularCarcinomaInSitu Although the name includes the term carcinoma, lobular carcinoma in situ (LCIS) is not really cancer, but rather a noninvasive condition that increases the risk of developing cancer in the future. LCIS, also known as lobular neoplasia or stage 0 breast cancer, occurs when abnormal cells accumulate in the breast lobules. Each breast has hundreds of milk producing lobules, which are connected to the milk ducts. In LCIS, the abnormal cells are often found throughout the breast lobules and both breasts are affected about 30 percent of the time. MCBCC_0000348:AcantholyticSquamousCellCarcinomaOfBreast Primary acantholytic squamous cell carcinoma (ASCC) of the breast is a rare and aggressive variant of invasive breast cancer. Breast Disease Breast Disease, Endocrine Breast Diseases, Endocrine Disease, Breast Disease, Endocrine Breast Diseases, Breast Diseases, Endocrine Breast Endocrine Breast Disease Endocrine Breast Diseases Pathological processes of the breast. Inflammatory Breast Cancer (IBC) is a very aggressive type of breast cancer in which the cancer cells block the lymph vessels in the skin of the breast. This type of breast cancer is called “inflammatory” because the breast often looks swollen and red, or “inflamed”, sometimes overnight and can be misdiagnosed as mastitis. Invasion of the local lymphatic ducts impairs drainage and causes edematous swelling of the breast. Metastatic carcinoma of the breast. Medullary carcinoma of the breast is a variant of breast cancer. These tumors have a similar presentation to other breast cancers but are distinguished by a characteristic histologic appearance. In addition, pure medullary carcinomas have a better prognosis than usual cases of infiltrating ductal carcinoma. Papillary carcinoma is a type of ductal carcinoma in situ (DCIS). This type of breast cancer is rarely invasive, and usually stays within the milk ducts of your breast. Papilla (a projection) refers to the microscopic shape of the cancer cells, which resemble fingers, or threads. An infiltrating ductal breast carcinoma associated with stromal fibrosis. SCC of the breast was first reported in 1908 by Troell. It is thought to arise directly from the epithelium of the mammary ducts, although an alternate theory is that the tumor arises from foci of squamous metaplasia within a preexisting adenocarcinoma of the breast. Squamous cell carcinoma (SCC) of the breast is rare and generally aggressive. Adenocarcinoma of the breast. Adenoses, Microglandular Adenosis of Breast Adenosis, Microglandular Breast Adenosis Breast Cystic Disease Breast Cystic Diseases Breast Disease, Cystic Breast Disease, Fibrocystic Breast Dysplasia Breast Fibrocystic Change Breast Fibrocystic Changes Breast Fibrocystic Disease Chronic Cystic Mastitis Cystic Breast Disease Cystic Disease of Breast Cystic Mastitis, Chronic Disease, Cystic Breast Disease, Fibrocystic Breast Dysplasia, Breast Dysplasia, Mammary Fibrocystic Changes of Breast Fibrocystic Disease of Breast Fibrocystic Mastopathy Mammary Dysplasia Mastopathy, Fibrocystic Microglandular Adenoses Microglandular Adenosis A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including fibrosis, formation of cysts, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency. Carcinoma, Ductal, Breast Carcinoma, Infiltrating Duct Carcinoma, Invasive Ductal, Breast Carcinoma, Mammary Ductal Carcinomas, Infiltrating Duct Carcinomas, Mammary Ductal Invasive Ductal Carcinoma, Breast Mammary Ductal Carcinoma Mammary Ductal Carcinomas An invasive (infiltrating) carcinoma of the mammary ductal system (mammary glands) in the human breast. Invasive Lobular Carcinoma (ILC) is a type of breast cancer that starts in the lobules of your breast, where milk is produced. At first, the cancer cells are at work in the lining of the milk lobes, but later these cells invade, or infiltrate, the nearby tissue outside of the lobes. As with invasive ductal carcinoma (IDC), ILC has the potential to spread, or metastasize, to other parts of your body. Breast Benign Neoplasm Breast Benign Neoplasms Breast Cancer Breast Cancers Breast Neoplasm Breast Neoplasm, Benign Breast Neoplasms, Benign Breast Tumor Breast Tumors Neoplasm of the breast. Mucinous (colloid) carcinoma is a rare type of invasive breast cancer that is formed when cancer cells within your breast produce mucous. This mucous contains breast cancer cells that are easily distinguished from normal cells under a microscope. Together, the mucous and cancer cells form a jelly-like tumor. Most mucinous carcinomas of the breast are estrogen-receptor positive and HER2/neu negative. This type of breast cancer rarely spreads to your lymph nodes. Tubular carcinoma is a rare type of invasive ductal carcinoma of the breast. It takes its name from its microscopic appearance, in which the cancer cells resemble small tubes. Tubular carcinomas tend to be small, estrogen-receptor positive, HER2/neu negative. In some cases, tubular cancer cells are mixed with ductal or lobular cancer cells, giving a mixed-tumor diagnosis. fma3:AbdominalLymphNodes Within the abdominal cavity, nodes occur in chains along the main branches of the arteries of the intestine and the abdominal aorta. fma3:AnatomicalEntity Biological entity, which constitutes the structural organization of a biological organism, or is an attribute of that organization. fma3:AxillaryLymphNodes These nodes are in the underarm region and receive lymph from vessels that drain the arm, the walls of the thorax, the breast, and the upper walls of the abdomen. Encephalon Encephalons fma3:Brain The part of Central Nervous System that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem. fma3:Cardinal_body_part Anatomical areas of the body. fma3:ChestWallNodule Nodules in chest wall fma3:ExocrineGland Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands) fma3:ImmuneSystem The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. fma3:InguinalLymphNodes These nodes receive lymph from the legs, the outer portion of the genitalia and the lower abdominal wall. fma3:Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. fma3:LymphNode They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. fma3:Lymph_node_of_neck These nodes are grouped along the lower border of the jaw, in front of and behind the ears, and deep in the neck along the larger blood vessels. They drain the skin of the scalp, face, tissues of the nasal cavity, and the pharynx. fma3:LymphaticSystem A system of organs and tissues that process and transport immune cells and lymph. Lymphatic_Tissue Lymphatic_Tissues Lymphoid_Tissues Tissue,_Lymphatic Tissue,_Lymphoid Tissues,_Lymphatic Tissues,_Lymphoid fma3:LymphoidTissue Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of lymphocytes can form, mature and multiply. The lymphoid tissues are connected by a network of lymphatic vessels. fma3:NervousSystem The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. fma3:PelvicLymphNodes The nodes here appear mostly along the paths of the blood vessels within the pelvic cavity and receive lymph from the lymphatic vessels in the area. Respiratory_Tract Respiratory_Tracts fma3:RespiratorySystem The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about. fma3:ThoracicLymphNodes These nodes occur between the lungs and along the windpipe and bronchi, and receive lymph from this area and from the internal wall of the thorax. fma3:ThoracicWall The outer margins of the thorax containing skin, deep fascia; thorasic vertebrae; ribs; sternum; and muscles. Chest fma3:Thorax The upper part of the trunk between the neck and the abdomen. It contains the chief organs of the circulatory and respiratory systems. Alveoli,_Mammary Alveolus,_Mammary Duct,_Mammary Ducts,_Mammary Epithelia,_Mammary Epithelium,_Mammary Gland,_Mammary Glands,_Mammary Mammary_Alveoli Mammary_Alveolus Mammary_Duct Mammary_Ducts Mammary_Epithelia Mammary_Epithelium Mammary_Gland Mammary_Glands Mammary_Lobule Mammary_Lobules fma3:lactiferous_gland Glandular tissue in the breast that is under the influence of hormones such as estrogens; progestins; and prolactin. After parturition, the mammary glands secrete milk for the nourishment of the young. fma3:neuraxis The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges. fma3:portion_of_tissue Collections of differentiated cells, such as epithelium; connective tissue; muscles; and nerve tissue. Tissues are cooperatively arranged to form organs with specialized functions such as respiration; digestion; reproduction; movement; and others. 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