Chaoying Zhan The myocardial infarction ontology (MIO) is a disease-specific ontology that characterizes the knowledge field of myocardial infarction. en myocardial infarction ontology (MIO) V1.0.0 NCIT:C25641 A note acknowledging a source of information or quoting a passage. [url:http://purl.obolibrary.org/obo/NCIT_C25641] reference The ID of entites in MIO. MIO_ID NCIT:C25393 A written explanation, observation or criticism added to textual material. [url:http://purl.obolibrary.org/obo/NCIT_C25393] comment comments remark remarks NCIT:P97 A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software. [url:http://purl.obolibrary.org/obo/NCIT_P97] definition NCIT:C45561 A brief description given for purposes of identification; an identifying or descriptive marker that is attached to an object. [url:http://purl.obolibrary.org/obo/NCIT_C45561] label tag synonyms SCDO:1000202 A relationship between a condition (a phenotype or disease) and an entity (e.g. environment) or condition (phenotype or disease) which could be an existing condition or an event, where the entity or second condition has a causal role for the condition being described. (url: http://purl.obolibrary.org/obo/SCDO_1000202) caused_by caused by differential_diagnosis differential diagnosis CIDO:0000124 An object property that represents a relation between a drug and a protein where the drug can target the protein. [url:http://purl.obolibrary.org/obo/CIDO_0000124] drug_target drug has protein target drug target has_complication has_diagnostic_imaging home_care_patients MIO:3088 Individuals who are receiving medical care or assistance while remaining at home rather than in a hospital or other healthcare facility. home care patients hospitalized_patients MIO:3089 Individuals who are admitted to a hospital for medical care, treatment, or observation. hospitalized patients inpatients MIO:3090 Individuals who receive medical treatment, care, or diagnostic services without being admitted to a hospital or healthcare facility for an overnight stay. outpatients patients NCIT: C16960 MIO: 03087 A person who receives medical attention, care, or treatment, or who is registered with medical professional or institution with the purpose to receive medical care when necessary. [url: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16960] patients patient NCIT:C27996 MIO:00000 Necrosis of the myocardium, as a result of interruption of the blood supply to the area. A condition which occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle. Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis. A disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area. [url:http://purl.obolibrary.org/obo/NCIT_C27996] myocardial infarction-related concepts MI MI, myocardial infarction heart attack myocardial infarct myocardial infarction (MI) CLAO:0001117 MIO:00001 Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. [ SPDrf : CARO ] [url:http://purl.obolibrary.org/obo/CLAO_0001117] anatomical entity anatomic structure NCIT:C3367 MIO:00002 Clinical, laboratory or molecular evidence, or absence of evidence of disease. [url:http://purl.obolibrary.org/obo/NCIT_C3367] clinical finding clinical findings finding observable entity NCIT:C15220 MIO:00003 The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation. [url:http://purl.obolibrary.org/obo/NCIT_C15220] diagnosis diagnosed diagnostic ExO:0000103 MIO:00004 Other conditions with the power to have an effect on health status. [url:http://purl.obolibrary.org/obo/ExO_0000103] influencing factor influencing factors MIO:00005 Myocardial infarction (MI) is a common cardiovascular disease and a leading cause of death worldwide. MI has different classification methods, which can be classified according to the disease phase, electrocardiogram (ECG) expression, infarction location, clinical classification, clinical manifestation coronary stenosis, etc. myocardial infarction MI type myocardial infarction subcategory myocardial infarction subtype myocardial infarction subtypes myocardial infarction type myocardial infarction types subcategory of myocardial infarction subtype of myocardial infarction subtypes of myocardial infarction type of myocardial infarction types of myocardial infarction NCIT:C20200 MIO:00006 The result of an action. A specific result or effect that can be measured. Examples of outcomes include decreased pain, reduced tumor size, and improvement of disease. The measureable characteristic (clinical outcome assessment, biomarker) that is influenced or affected by an individual's baseline state or an intervention, as in a clinical trial or other exposure. NOTE: Outcome can be a result of analysis and is more general than endpoint in that it does not necessarily relate to a planned objective of the study outcome (SDTM). [After BEST Resource] See also variable, observation. Events or experiences that clinicians or investigators examining the impact of an intervention or exposure measure because they believe such events or experiences may be influenced by the research intervention or exposure. Outcome is a general term in that it does not necessarily relate to a planned objective of the study. (FDA) [url:http://purl.obolibrary.org/obo/NCIT_C20200] outcome outcomes result NCIT:C18264 MIO:00007 The pathologic, physiologic, or biochemical mechanism resulting in the development of a disease or morbid process. [url:http://purl.obolibrary.org/obo/NCIT_C18264] pathogenesis NCIT:C16960 MIO:00008 A person who receives medical attention, care, or treatment, or who is registered with medical professional or institution with the purpose to receive medical care when necessary. [url:http://purl.obolibrary.org/obo/NCIT_C16960] patients-related concepts patient GSSO:003443 MIO:00009 There is a large crossover between the lifestyle and activity recommendations to prevent a myocardial infarction, and those that may be adopted as secondary prevention after an initial myocardial infarction, because of shared risk factors and an aim to reduce atherosclerosis affecting heart vessels. The influenza vaccine also appear to protect against myocardial infarction with a benefit of 15 to 45%. [url:https://en.wikipedia.org/wiki/Myocardial_infarctionPrevention] prevention preventions preventive intervention prophylaxis EFO:0000727 MESH:D013812 MIO:00010 A planned process intended to modify or alter a condition or characteristic of an individual with myocardial infarction. [url:http://www.ebi.ac.uk/efo/EFO_0000727] treatment therapeutic procedure therapeutics therapy NCIT:C12686 MIO:00011 Relating to the heart and the blood vessels or the circulation. [url:http://purl.obolibrary.org/obo/NCIT_C12686] cardiovascular system body system, cardiovascular cardiovascular cardiovascular body system cardiovascular organ system circulatory system organ system, cardiovascular vascular, heart NCIT:C35552 MIO:00012 Symptoms, physical examination results, and/or laboratory test results related to the cardiovascular system. [url:http://purl.obolibrary.org/obo/NCIT_C35552] cardiovascular system finding NCIT:C16457 MIO:00013 The coexistence of two or more disease processes. [url:http://purl.obolibrary.org/obo/NCIT_C16457] comorbidity co-morbid conditions co-morbidities co-morbidity comorbidities medical comorbidities NCIT:C2959 MIO:00014 A complication in medicine, or medical complication, is an unfavorable result of a disease, health condition, or treatment. Complications may adversely affect the prognosis, or outcome, of a disease. Complications generally involve a worsening in severity of disease or the development of new signs, symptoms, or pathological changes which may become widespread throughout the body and affect other organ systems. Thus, complications may lead to the development of new diseases resulting from a previously existing disease. Complications may also arise as a result of various treatments. [url:https://en.wikipedia.org/wiki/Complication_(medicine)] complication complications medical complication NCIT:C36292 MIO:00015 The outcome of a laboratory test. [url:http://purl.obolibrary.org/obo/NCIT_C36292] laboratory test result lab findings lab result laboratory finding laboratory report laboratory test result labs test result test_result HP:0032443 NCIT:C18772 MIO:00016 In a medical encounter, the physician generally will interview the patient about his or her current problem, and may perform additional testing. The past medical history (PMH) in contrast records information about the patient's medical, personal and family history that might be relevant to the presenting illness or to provide optimal clinical management. The PMH generally includes (if relevant) other major illnesses, hospitalizations, surgeries, injuries, allergies, gynecologic and obstetric history, family history, personal history including occupational history, alcohol and drug use, etc. [url:http://purl.obolibrary.org/obo/HP_0032443] personal medical history general medical history medical history past medical history personal health record personal history NCIT:C100104 MIO:00017 Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom). [url:http://purl.obolibrary.org/obo/NCIT_C100104] sign or symptom clinical signs clinical signs or symptoms sign or symptom signs or symptoms symptom SNOMED:386053000 MIO:00018 Any procedure or test to diagnose a disease or disorder. [ NCI ] A specific test or series of steps done to help diagnose a disease or condition. Mammograms and colonscopies are examples of diagnostic procedures. [url:http://purl.obolibrary.org/obo/NCIT_C18020] diagnostic procedure diagnostic measurement diagnostic method diagnostic technique diagnostic test SIO:001002 MIO:00019 A differential diagnosis (sometimes abbreviated DDx, ddx, DD, D/Dx, or ΔΔ) is a systematic diagnostic method used to identify the presence of an entity where multiple alternatives are possible (and the process may be termed differential diagnostic procedure), and may also refer to any of the included candidate alternatives (which may also be termed candidate condition). [url:https://semanticscience.org/resource/SIO_001002.rdf] differential diagnosis NCIT:C117960 MIO:00020 A standard from which a judgment concerning a medical diagnosis can be established. [url:http://purl.obolibrary.org/obo/NCIT_C117960] diagnostic criteria MIO:00021 Factors about biochemistry. biochemical factor biochemical factors NCIT:C79751 MIO:00022 Any stepwise set of actions. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79751] procedure MIO:00023 Clinical factors include abnormal phenotype, treatment factors, personal medical history, etc. clinical factor clinical factors EFO:0000469 NCIT:C18244 MIO:00024 Health hazards at home, in the work place, or in nature (e.g., infectious agents, irritants, respiratory fibrotic agents, asphyxiants, allergens, metabolic poisons, physical agents, mutagens, teratogens, and carcinogens). (Winett et al: Health Psychology and Public Health) [url:http://purl.obolibrary.org/obo/NCIT_C18244] environmental factor environmental risk factor MIO:00025 An imaging feature is a biologic feature detected in an image. imaging feature GSSO:003697 NCIT:C16795 SCDO:0000689 MIO:00026 The interests, opinions, behaviours, and behavioral orientations of an individual, group, or culture. [url:http://purl.obolibrary.org/obo/GSSO_003697] lifestyle life style life-style lifestyle factor lifestyle factors MIO:00027 aspects regarding the acts of a living organism and its parts in addition to the physical and chemical procedures engaged in these acts. [url:https://psychologydictionary.org/physiological-factors/] physiological factor NCIT:C94434 MIO:00028 Something that may decrease the chance of getting a certain disease. Some examples of protective factors for cancer are getting regular physical activity, staying at a healthy weight, and having a healthy diet. [url:http://purl.obolibrary.org/obo/NCIT_C94434] protective factor protective factors MIO:00029 Psychosocial factors include personality and presence of psychiatric disorder, as well as family, peer, and other environmental factors that either increase the risk of an individual developing an addictive disorder (risk factors) or decrease such risks (protective factors). [url:https://nap.nationalacademies.org/read/5802/chapter/6] psychosocial factor psychosocial factors NCIT:C17103 MIO:00030 Any aspect of an individual's life, behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of a disease, condition or injury. [url:http://purl.obolibrary.org/obo/NCIT_C17103] risk factor risk factors risk_factor DOID:9408 EFO:0008583 ICD11:BA41 NCIT:C35204 SNOMED:57054005 MIO:00031 The term acute myocardial infarction (MI) should be used when there is evidence of myocardial necrosis in a clinical setting consistent with acute myocardial ischemia. Under these conditions any one of the following criteria meets the diagnosis for MI; Detection of a rise and/or fall of cardiac biomarker values with at least one value above the 99th percentile upper reference limit (URL ) and with at least one of the following; a. Symptoms of ischaemia. b. New or presumed new significant ST-segment-T wave (ST-T) changes or new left bundle branch block (LBBB). c. Development of pathologic Q waves in the ECG. d. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality. e. Identification of an intracoronary thrombus by angiography or autopsy. Infarction of any myocardial site, occurring within 4 weeks (28 days) from onset of a previous infarction (WHO).[url:http://id.who.int/icd/entity/1334938734] Necrosis of the myocardium, as a result of interruption of the blood supply to the area. It is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations. [url:http://purl.obolibrary.org/obo/NCIT_C35204] acute myocardial infarction AMI acute MI acute myocardial infarction (AMI) myocardial infarction NCIT:C71069 SNOMED:429731003 MIO:00032 An electrocardiographic finding of pathologic Q waves in leads V3 and V4, which is suggestive of myocardial infarction of the anterior wall of the left ventricle. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C71069] anterior myocardial infarction anterior MI anterior wall myocardial infarction DOID:5845 EFO:1000812 MESH:D056988 NCIT:C35303 SNOMED:43630006 UMLS:C0262564 MIO:00033 Myocardial infarction in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction. [ MESH:D056988 ] [url:http://www.ebi.ac.uk/efo/EFO_1000812] anterolateral myocardial infarction anterolateral wall myocardial infarction infarcts in the LAD territory DOID:5855 MESH:D056988 NCIT:C35304 SNOMED:164868007 UMLS:C0262565 MIO:00034 An electrocardiographic finding of pathologic Q waves in leads V1 through V4, which is suggestive of myocardial infarction of the anteroseptal wall of the left ventricle. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C35304] anteroseptal myocardial infarction anteroseptal MI anteroseptal wall myocardial infarction DOID:5850 EFO:1000983 MESH:D056989 NCIT:C35398 SNOMED:7326005 UMLS:C0340305 MIO:00035 An electrocardiographic finding of pathologic Q waves in leads III, aVF and often II, which is suggestive of myocardial infarction of the inferior wall of the left ventricle. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C35398] inferior myocardial infarction diaphragmatic myocardial infarction inferior MI inferior wall myocardial infarction DOID:5852 NCIT:C35673 UMLS:C3537017 MIO:00036 An electrocardiographic finding of an injury in leads corresponding to the anatomic region of the inferolateral wall of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C35673] inferolateral myocardial infarction inferolateral myocardial infarct DOID:5845 MESH:D056988 NCIT:C35586 UMLS:C0262564 MIO:00037 An electrocardiographic finding of pathologic Q waves in leads V5, V6, I and aVL, which is suggestive of myocardial infarction of the lateral wall of the left ventricle. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C35586] lateral myocardial infarction lateral MI lateral wall extension lateral wall infarction lateral wall myocardial infarction SNOMED:371068009 MIO:00038 myocardial infarction with complication PMID:30571511 MIO:00039 It is increasingly recognized that there is a group of MI patients with no angiographic obstructive CAD (≥50% diameter stenosis in a major epicardial vessel), and the term myocardial infarction with non-obstructive coronary arteries (MINOCA) has been coined for this entity. The diagnosis of MINOCA, like the diagnosis of MI, indicates that there is an ischaemic mechanism responsible for the myocyte injury (i.e., non-ischaemic causes such as myocarditis have been excluded). [url:https://www.sciencedirect.com/science/article/pii/S0735109718369419?via%3Dihubsec24] myocardial infarction with non-obstructive coronary arteries MINOCA myocardial infarction with unobstructed coronary arteries myocardial infarction without obstructive coronary arteries MESH:D000072658 NCIT:C80383 MIO:00040 An electrocardiographic finding of a myocardial infarction that does not produce elevations in the ST segment of the EKG. [url:http://purl.obolibrary.org/obo/NCIT_C80383] non-ST elevation myocardial infarction NSTEMI endocardial extent of myocardial infarction endocardial myocardial infarction non-Q wave myocardial infarction non-ST elevated myocardial infarction non-ST elevation MI non-ST segment elevation myocardial infarction non-transmural myocardial infarction nontransmural myocardial infarction subendocardial MI subendocardial myocardial infarction ICD11:BA50 NCIT:C101597 NCIT:C35400 SNOMED:164867002 MIO:00041 An electrocardiographic finding of pathologic Q waves, which is suggestive of myocardial infarction of one or more regions of the heart, without evidence of current or ongoing acute infarction. No specification is provided for localization. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C101597] old myocardial infarction healed myocardial infarction history of myocardial infarction history of previous infarction history of previous myocardial infarction old MI previous MI previous infarct previous myocardial infarction prior MI prior myocardial infarction PMID:30571511 SNOMED:703212004 MIO:00042 There is no universal consensus on the cTn or hs-cTn cut-off points that clearly distinguish cardiac procedural myocardial injury from MI. The distinction is made on the basis of an injury created by a flow-limiting complication during the procedure that results in sufficient myocardial ischaemia to generate a procedure-related MI. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] periprocedural myocardial infarction PMI myocardial infarction during procedure perioperative MI periprocedural MI periprocedural MIs DOID:5847 NCIT:C35399 SNOMED:73999000 UMLS:C0340319 MIO:00043 An electrocardiographic finding in leads V1 or V2 of an initial R wave duration greater than or equal to 40 ms, R wave greater than S wave, and upright T wave, which is suggestive of myocardial infarction of the posterior wall of the left ventricle. Evidence of inferior or lateral myocardial infarction is usually also present. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C35399] posterior myocardial infarction posterior MI posterior infarction posterior wall myocardial infarction DOID:5843 NCIT:C36068 UMLS:C3642318 MIO:00044 An electrocardiographic finding of an injury in leads corresponding to the anatomic region of the posteroinferior wall of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C36068] posteroinferior myocardial infarction DOID:5846 NCIT:C35519 UMLS:C0746727 MIO:00045 An electrocardiographic finding suggesting an infarction in the anatomic location of the cardiac septum. [url:http://purl.obolibrary.org/obo/NCIT_C35519] septal myocardial infarction DOID:5854 NCIT:C35400 SNOMED:233843008 UMLS:C0340324 MIO:00046 An electrocardiographic finding that a myocardial infarction has occurred concurrently with the absence of clinical symptoms. [url:http://purl.obolibrary.org/obo/NCIT_C101598] silent myocardial infarction SMI silent MI unrecognized myocardial infarction MESH:D000072657 NCIT:C101888 MIO:00047 A myocardial infarction that produces elevation in the ST segments of the ECG. [url:http://purl.obolibrary.org/obo/NCIT_C101888] ST elevation myocardial infarction Q wave MI Q wave myocardial infarction ST elevated myocardial infarction ST elevation MI ST-elevation MI ST-elevation myocardial infarction ST-elevation myocardial infarction (STEMI) ST-segment elevation myocardial infarction STEMI STEMI, ST-segment elevation myocardial infarction transmural myocardial infarction NCIT:C119220 PMID:30571511 MIO:00048 MI caused by atherothrombotic coronary artery disease (CAD) and usually precipitated by atherosclerotic plaque disruption (rupture or erosion) is designated as a type 1 MI. The relative burden of atherosclerosis and thrombosis in the culprit lesion varies greatly, and the dynamic thrombotic component may lead to distal coronary embolization resulting in myocyte necrosis. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] type 1 myocardial infarction myocardial infarction type 1 type 1 MI type I MI type I myocardial infarction NCIT:C119221 PMID:30571511 MIO:00049 The pathophysiological mechanism leading to ischaemic myocardial injury in the context of a mismatch between oxygen supply and demand has been classified as type 2 MI. By definition, acute atherothrombotic plaque disruption is not a feature of type 2 MI. In patients with stable known or presumed CAD, an acute stressor such as an acute gastrointestinal bleed with a precipitous drop in hemoglobin or a sustained tachyarrhythmia with clinical manifestations of myocardial ischemia, may result in myocardial injury and a type 2 MI. These effects are due to insufficient blood flow to the ischemic myocardium to meet the increased myocardial oxygen demand of the stressor. Ischemic thresholds may vary substantially in individual patients depending on the magnitude of the stressor, the presence of noncardiac comorbidities, and the extent of underlying CAD and cardiac structural abnormalities. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] type 2 myocardial infarction myocardial infarction due to demand ischaemia myocardial infarction due to demand ischemia myocardial infarction type 2 type 2 MI type II MI type II myocardial infarction NCIT:C119222 PMID:30571511 MIO:00050 When a type 3 MI is diagnosed and a subsequent autopsy reveals recent evidence of an MI, with a fresh or recent thrombus in the infarct-related artery, the type 3 MI should be reclassified to a type 1 MI. Sudden unexpected cardiac death, including cardiac arrest, where symptoms may suggest MI, an ECG may be taken with suggestive changes, or a blood clot is found in a coronary artery by angiography and/or at autopsy, but where blood samples could not be obtained, or at a time before the appearance of cardiac biomarkers in the blood. [url:https://en.wikipedia.org/wiki/Myocardial_infarction] type 3 myocardial infarction type 3 MI type III MI type III myocardial infarction PMID:10532513 MIO:00051 aborted myocardial infarction aborted MI DOID:5848 NCIT:C36073 UMLS:C3642319 MIO:00052 An electrocardiographic finding of an injury in leads corresponding to the anatomic region of the apex of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C36073] apical myocardial infarction apical MI PMID: 1127069 MIO:00053 Clinical infarct refers to those subjects who complained of symptoms suggestive of heart disease and who in addition had at least one of the following: a. ECG showing signs of probable or possible infarct. (cf. criteria in previous publication. b. Autopsy findings showing evidence of recent MI and/or coronary thrombosis. c. A composite of clinical, laboratory and ECG diagnosis in subjects who were hospitalized and in whom the composite picture of clinical signs and symptoms, changes in laboratory findings (transaminase, sedimentation rates, leucocytes, etc.) and ECG ischemic changes, together, led to the diagnosis of probable MI. d. Sudden death, i.e. death occurring within 1 hr of onset of symptoms in a person who was not hospitalized or confined to bed. In other words, it was an unexpected death. Autopsy studies have shown that the majority of these are due to MI. [url:https://pubmed.ncbi.nlm.nih.gov/1127069/] clinical myocardial infarction CMI clinical infarct recognized myocardial infarction typical myocardial infarction SNOMED:394710008 MIO:00054 Myocaridial infarction for the first time. first myocardial infarction first MI DOID:5851 NCIT:C35672 UMLS:C3642463 MIO:00055 An electrocardiographic finding of an injury in leads corresponding to the anatomic region of the posterolateral wall of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C35672] posterolateral myocardial infarction NCIT:C17013 MIO:00056 Prediction of the probable course and outcome of myocardial infarction. [url:http://purl.obolibrary.org/obo/NCIT_C17013] prognosis NCIT:C18919 MIO:00057 The result of therapy for a given disease or condition in a patient or group of patients. [url:http://purl.obolibrary.org/obo/NCIT_C18919] outcome of therapy therapy effect therapy outcome treatment effect treatment outcome APOLLO_SV:00000204 NCIT:C18226 MIO:00058 A processual entity that is either the outcome of a disease course or a part of a disease course and has etiological relevance. [url:http://purl.obolibrary.org/obo/APOLLO_SV_00000204] disease outcome PMID:30153967 MIO:00059 imbalance between the heart's oxygen demand and supply oxygen supply and demand imbalance imbalance between myocardial oxygen supply and demand mismatch between oxygen supply and demand oxygen supply/demand imbalance supply-demand mismatch SNOMED:449873008 MIO:00060 atherosclerotic plaque disruption with thrombosis atherosclerotic plaque disruption with thrombosis of artery NCIT:C15306 PMID:30563358 UMLS:C0033144 MIO:00062 The adjunctive therapies of proven benefit in the primary prevention of myocardial infarction include statins, blood pressure medications, aspirin, and drugs to treat insulin resistance and hyperglycemia. [url:https://pubmed.ncbi.nlm.nih.gov/30563358/] primary prevention NCIT:C15712 UMLS:C0679699 MIO:00063 Procedures or treatment processes designed to prevent complications (e.g., modifying a drug or surgical procedure to prevent complications). [url:http://purl.obolibrary.org/obo/NCIT_C15712] secondary prevention NCIT:C49803 SNOMED:112802009 UMLS:C0038897 MIO:00064 Cardiothoracic surgery is the field of medicine involved in surgical treatment of organs inside the thoracic cavity — generally treatment of conditions of the heart (heart disease), lungs (lung disease), and other pleural or mediastinal structures. [url:https://en.wikipedia.org/wiki/Cardiothoracic_surgery] cardiovascular surgical procedure cardiothoracic surgery cardiovascular operation cardiovascular operative procedure cardiovascular surgery surgical procedure on cardiovascular system EFO:0010064 NCIT:C15986 MIO:00065 Treatment with any substance, other than food, that is used to prevent, diagnose, treat, or relieve symptoms of a disease or abnormal condition. [url:http://purl.obolibrary.org/obo/NCIT_C15986] pharmacotherapy MI pharmacotherapy drug therapy drug treatment pharmaceutical drug pharmaceutical therapy pharmacoinvasive treatment pharmacological treatment pharmacological treatments NCIT:C100067 UMLS:C0027054 MIO:00066 Procedures intended to re-establish normal coronary flow. Reperfusion therapy includes thrombolysis and primary percutaneous coronary intervention (PCI). Reperfusion therapy also includes per-hospital thrombolytics. [url:http://purl.obolibrary.org/obo/NCIT_C100067] reperfusion therapy coronary reperfusion procedure reperfusion therapies NCIT:C15747 UMLS:C0344211 MIO:00067 Supportive care is that which helps the patient and their family to cope with cancer and treatment of it from pre-diagnosis, through the process of diagnosis and treatment, to cure, continuing illness or death and into bereavement. It helps the patient to maximize the benefits of treatment and to live as well as possible with the effects of the disease. Supportive therapy may provide a patient with friendship, encouragement, practical advice such as access to community resources or how to develop a more active social life, vocational counseling, suggestions for minimizing friction with family members, and, above all, hope that the life of the patient may be improved. In all situations, supportive therapy involves the teaching of such life skills as managing medication, learning to socialize, handling finances, and getting a job. [url:http://purl.obolibrary.org/obo/NCIT_C15747] supportive care supportive therapy NCIT:C101251 MIO:00068 Delivery of strong electrical impulses by a cardioverter defibrillator to return the electrical activity of the heart to normal. (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C101251] cardioverter defibrillator shock therapy cardiac defibrillator procedure NCIT:C70909 UMLS:C0199470 MIO:00069 A method to mechanically assist or replace spontaneous breathing in patients by use of a powered device that forces oxygenated air into the lungs. [url:http://purl.obolibrary.org/obo/NCIT_C70909] mechanical ventilation mechanical respiratory support respiratory support NCIT:C12727 SNOMED:80891009 MIO:00070 A hollow organ located slightly to the left of the middle portion of the chest. It is composed of muscle and it is divided by a septum into two sides: the right side which receives de-oxygenated blood from the body and the left side which sends newly oxygenated blood to the body. Each side is composed of two chambers: the atrium (receiving blood) and ventricle (ejecting blood). [url:http://purl.obolibrary.org/obo/NCIT_C12727] heart cardiac cardiac structure heart structure NCIT:C33854 MIO:00071 The cardiovascular and lymphatic systems, collectively. [url:http://purl.obolibrary.org/obo/NCIT_C33854] vascular system vascular system HP:0500015 MIO:00072 abnormal cardiac test SNOMED:251015000 MIO:00073 coronary artery finding NCIT:C41328 UMLS:C0438154 MIO:00074 Graphic representation and categorization of the electrical vectors produced by the depolarization and repolarization of myocardial tissue. [url:http://purl.obolibrary.org/obo/NCIT_C41328] electrocardiographic finding ECG Finding ECG findings electrocardiographic findings NCIT:C176716 MIO:00075 The result of an evaluation of an individual's ability to endure the workload that is achieved during a specified period of exercise. [url:http://purl.obolibrary.org/obo/NCIT_C176716] exercise tolerance test result exercise tolerance finding NCIT:C19253 MIO:00076 In epidemiology, a rating scale for comorbidity. [url:http://purl.obolibrary.org/obo/NCIT_C19253] comorbidity index comorbidity measure comorbidity measures measures of comorbidity MIO:00077 comorbidity of myocardial infarction comorbidity of MI DOID:3021 HP:0001919 ICD11:GB60 MESH:D058186 PMID:31860670 MIO:00078 An increase in serum creatinine by 0.3 mg/dl or greater within 48 hours; or Increase in serum creatinine by 1.5-fold or greater above baseline, which is known or presumed to have occurred within 7 days; or Urine volume less than 0.5 ml/kg/h for 6 hours or more. [url:http://id.who.int/icd/entity/476391827] acute kidney failure AKI acute kidney injury acute renal failure NCIT:C115199 MIO:00079 Any heart or vascular disorder occurring as a consequence of injury to the cardiovascular system. [url:http://purl.obolibrary.org/obo/NCIT_C115199] cardiovascular complication cardiac complication cardiac complications cardiovascular complications MIO:00080 inflammatory complication DOID:2224 NCIT:C3407 OMIM:187950 OMIM:601977 OMIM:614521 PMID:30626836 PMID:33558452 SNOMED:109994006 UMLS:C0040028 MIO:00081 A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage. It is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage. (WHO, 2008) [url:http://purl.obolibrary.org/obo/NCIT_C3407] essential thrombocythemia essential thrombocythaemia essential thrombocythemia familial thrombocytosis hemorrhagic thrombocythemia hereditary thrombocythemia idiopathic thrombocythemia primary Thrombocytosis OAE:0000040 MIO:00082 an adverse event that shows a complication that occurs after a medical procedure such as a surgery. [url:http://purl.obolibrary.org/obo/OAE_0000040] procedural complication procedural complications DOID:11396 HP:0100598 ICD11:CB01 MSH:D011654 NCIT:C26868 PMID:22850288 PMID:319645 PMID:8404085 SNOMED:19242006 UMLS:C0034063 MIO:00083 Pulmonary edema, also known as pulmonary congestion, is liquid accumulation in the tissue and air spaces of the lungs. [url:https://en.wikipedia.org/wiki/Pulmonary_edema] pulmonary edema pulmonary congestion NCIT:C81326 MIO:00084 A result of a test that is higher than a previous value or a normal range of values. [url:http://purl.obolibrary.org/obo/NCIT_C81326] elevated test result NCIT:C17726 PMID:29083808 MIO:00085 A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. [url:http://purl.obolibrary.org/obo/NCIT_C17726] family history family history of family history of disease family medical history SNOMED:312850006 MIO:00086 history of disorder GECKO:0000067 MIO:00087 A clinical history that is about the lifestyle and behaviors of an individual which may impact health outcomes. [url:http://purl.obolibrary.org/obo/GECKO_0000067] lifestyle history GECKO:0000115 MIO:00088 A clinical history that is about any treatment (surgical, prescription, etc.) for disease, disorder, or symptom. [url:http://purl.obolibrary.org/obo/GECKO_0000115] treatment history NCIT:C17655 MIO:00089 An account of all reproductive events and problems a person has experienced. An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage. [ NCI from On-line Medical Dictionary ] [url:http://purl.obolibrary.org/obo/NCIT_C17655] reproductive history reproductive factor reproductive factors reproductive issues HP:0031657 MIO:00090 The first two heart sounds, S1 and S2, define ventricular systole. S1 comprises the closure of the mitral and tricuspid valves. S2 is produced by aortic and pulmonic valve closure. [url:http://purl.obolibrary.org/obo/HP_0031657] abnormal heart sound HP:0032016 MIO:00091 Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin. [url:http://purl.obolibrary.org/obo/HP_0032016] abnormal sputum abnormal sputum morphology SYMP:0000208 MIO:00092 Anaemia is a decrease in normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. [url:http://purl.obolibrary.org/obo/SYMP_0000208] anaemia anemia EFO:0003913 NCIT:C51221 UMLS:C0002962 MIO:00093 A heart condition marked by paroxysms of chest pain due to reduced oxygen to the heart. Chest pain secondary to decreased blood flow to cardiac muscle. A disorder characterized by substernal discomfort due to insufficient myocardial oxygenation. Chest pain resulting from inadequate oxygen delivery for the needs of the myocardium. [url:http://purl.obolibrary.org/obo/NCIT_C51221] angina pectoris angina anginal pain angor pectoris HP:0011675 ICD11:BA60.8 NCIT:C2881 OAE:0000590 PMID:15760518 PMID:29083808 PMID:5307390 SNOMED:698247007 MIO:00094 A large and heterogeneous group of conditions in which the heart beats with an irregular or abnormal rhythm that can complicate the course of patients with acute myocardial infarction. [url:http://id.who.int/icd/entity/1063181491] arrhythmia abnormal heart rate adverse arrhythmic cardiac events arrhythmias arrhythmic endpoint arrhythmic events cardiac arrhythmia cardiac arrhythmia events cardiac arrhythmias cardiac dysrhythmia cardiac rhythm disturbances disorder of heart rhythm heart rhythm disorders irregular heart beat irregular heart rate irregular heartbeat major arrhythmic event malignant arrhythmia malignant arrhythmia events PMID:22363379 MIO:00095 The cluster with atypical symptoms was characterized by the least chest pain and moderate frequencies of gastrointestinal symptoms, weakness or fatigue, and shortness of breath. [url:https://pubmed.ncbi.nlm.nih.gov/22363379/] atypical symptom cluster atypical symptom atypical symptoms cluster with atypical symptoms presenting symptom other than chest pain ICD11:MD12 MSH:D003371 NCIT:C37935 PMID:11182180 PMID:16020420 SNOMED:49727002 UMLS:C0010200 MIO:00096 Cough is an important natural defensive mechanism and protective reflex for clearing the upper and lower airways of excessive secretions such as mucus and inhaled particles. Cough is a common symptom of most respiratory disorders and may be indicative of trivial to very serious airway or lung pathology. [url:http://id.who.int/icd/entity/2027526159] cough cughing NCIT:C37942 MIO:00097 Extreme mental or physical pain or suffering. A state of physiological or psychological stress that cannot be compensated for by normal adaptive measures. [url:http://purl.obolibrary.org/obo/NCIT_C37942] distress HP:0000969 ICD11:MG29 MSH:D004487 NCIT:C3002 PMID:29083808 PMID:33652063 SNOMED:79654002 UMLS:C0013604 MIO:00098 Extremities may show edema or cyanosis and will be cold.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body. [url:http://purl.obolibrary.org/obo/HP_0000969] edema oedema NCIT:C3038 PMID:29083808 MIO:00099 Fever is not uncommon.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] Elevation of body temperature above normal due to inflammatory or immune responses. [url:http://purl.obolibrary.org/obo/NCIT_C3038] fever pyrexia NCIT:C3429 PMID:30807351 MIO:00100 Involuntary passage of stool or urine from the body. [url:http://purl.obolibrary.org/obo/NCIT_C3429] incontinence PMID:30153967 MIO:00101 Possible ischaemic symptoms include various combinations of chest, upper extremity, mandibular, or epigastric discomfort during exertion or at rest, or an ischaemic equivalent such as dyspnoea or fatigue. [url:https://pubmed.ncbi.nlm.nih.gov/30153967/] ischemic symptom ischaemic symptom ischaemic symptoms ischemic symptoms symptoms of acute myocardial ischemia symptoms of myocardial ischemia HP:0002360 ICD11:MG41 NCIT:C3376 PMID:20071239 PMID:31447516 SNOMED:53888004 UMLS:C0037317 MIO:00102 An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness. [url:http://purl.obolibrary.org/obo/HP_0002360] sleep disturbance difficulty sleeping sleep disorder sleep disturbance sleep dysfunction trouble sleeping NCIT:C9232 MIO:00103 An increase or decrease in the weight of an individual. [url:http://purl.obolibrary.org/obo/NCIT_C9232] weight change ICD11:MD11.1 NCIT:C50465 PMID:12087893 MIO:00104 Asphyxia is a life-threatening condition in which oxygen is prevented from reaching the tissues by obstruction of or damage to any part of the respiratory system. More generally the term indicates all the conditions generating impaired or impeded breathing. [url:http://id.who.int/icd/entity/2008663041] asphyxia ICD11:MD91 NCIT:C143198 PMID:11182180 SNOMED:275299008 MIO:00105 The liberation of gas in the upper gastrointestinal tract via the oesophagus through the mouth. [url:http://id.who.int/icd/entity/1093292760] belching HP:0031352 PMID:30807351 MIO:00106 An unpleasant sensation of tightness or pressure in the chest. [url:http://purl.obolibrary.org/obo/HP_0031352] chest distress tightness in chest tightness of chest NCIT:C50494 PMID:29083808 SNOMED:373909009 UMLS:C0008301 MIO:00107 Interference with respiration by compression or obstruction of the larynx or trachea. choking choking sensation NCIT:C50495 MIO:00108 Pain, cramping, and fatigue of the lower extremities upon ambulation due to ischemia. [url:http://purl.obolibrary.org/obo/NCIT_C50495] claudication lameness limping NCIT:C26737 PMID:29083808 UMLS:C2750144 MIO:00109 Extremities may show edema or cyanosis and will be cold.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] A bluish or purplish discoloration of the skin and mucous membranes resulting from a reduced concentration of oxygenated hemoglobin in the blood. [url:http://purl.obolibrary.org/obo/NCIT_C26737] cyanosis HP:0011037 NCIT:C80522 PMID:28710236 UMLS:C3887784 MIO:00110 A finding indicating that the urine production is less than 500 milliliters during a 24 hour period.[url:http://purl.obolibrary.org/obo/NCIT_C80522] A decreased rate of urine production. [url:http://purl.obolibrary.org/obo/HP_0011037] decreased urine output HP:0410281 ICD11:MD92 NCIT:C26756 PMID:16020420 MIO:00111 A heterogeneous group of symptoms that are localized in the epigastric region. Typical dyspeptic symptoms include postprandial fullness, early satiation, epigastric pain and epigastric burning, but other upper gastrointestinal symptoms such as nausea, belching or abdominal bloating often occur. [url:http://purl.obolibrary.org/obo/HP_0410281] dyspepsia indigestion HP:0033838 MIO:00112 A state of feeling very unhappy, uneasy, or dissatisfied. [url:http://purl.obolibrary.org/obo/HP_0033838] dysphoria HP:0033675 MIO:00113 There is no objective test for frailty. An operational definition recognizes frailty in an individual who has three out of the following five criteria: (i) low grip strength; (ii) low energy; (iii) slowed waking speed; (iv) low physical activity; and (v) unintentional weight loss.[url:http://purl.obolibrary.org/obo/HP_0033675] A clinically recognizable state of increased vulnerability resulting from a decline in reserve and function across multiple physiologic systems such that the ability to cope with everyday or acute stressors is compromised. [url:http://purl.obolibrary.org/obo/HP_0033675] frailty HP:0100247 ICD11:MD11.6 MSH:D006606 NCIT:C37966 PMID:11182180 PMID:21277137 PMID:31006602 SNOMED:65958008 UMLS:C0019521 MIO:00114 Hiccough are repeated involuntary spasms of the diaphragm followed by sudden closure of the glottis, which checks the inflow of air and causes the characteristic sound. Transient episodes are very common. Persistent (> 2 days) and intractable (> 1 mo) Hiccough are uncommon but quite distressing.[url:http://id.who.int/icd/entity/798509501] A contraction of the diaphragm that repeats several times per minute. In humans, the abrupt rush of air into the lungs causes the epiglottis to close, creating a hic sound. Also known as synchronous diaphragmatic flutter (SDF), or singultus, from the Latin singult, the act of catching one's breath while sobbing. The hiccup is an involuntary action involving a reflex arc. [url:http://purl.obolibrary.org/obo/HP_0100247] hiccough hiccup hiccups recurrent singultus recurrent synchronous diaphragmatic flutter, singultus HP:0031667 PMID:29083808 MIO:00115 Heart: lateral displacement of apical impulse, soft S1, palpable S4, new mitral regurgitation murmur. A loud holosystolic murmur radiating to the sternum may be indicative of ventricular septal rupture.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] A heart murmur that occurs during the entire systolic phase from S1 to S2. [url:http://purl.obolibrary.org/obo/HP_0031667] holosystolic murmur MSH:D007022 NCIT:C3128 PMID:34127584 SNOMED:45007003 UMLS:C0020649 MIO:00116 Low Blood Pressure, vascular hypotension. [url:http://purl.obolibrary.org/obo/HP_0002615] hypotension arterial hypotension low blood pressure ICD11:MB48.3 PMID:26989121 MIO:00117 light-headedness HP:0007185 MSH:D014474 NCIT:C50635 PMID:26989121 SNOMED:418107008 UMLS:C0041657 MIO:00118 An inability to purposefully respond to stimuli. [url:http://purl.obolibrary.org/obo/NCIT_C50635] loss of consciousness passing out unconscious HP:0002018 ICD11:MD90.0 MSH:D009325 NCIT:C3258 PMID:11182180 PMID:30807351 PMID:3458080 SNOMED:422587007 UMLS:C0027497 MIO:00119 A sensation of unease in the stomach together with an urge to vomit. [url:http://purl.obolibrary.org/obo/HP_0002018] nausea HP:0033050 ICD11:MD36.0 NCIT:C105054 PMID:21373323 SNOMED:162397003 MIO:00120 An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the throat. [url:http://purl.obolibrary.org/obo/HP_0033050] pharyngalgia pain in throat sore throat throat discomfort throat pain HP:0004396 ICD11:MG43.7 NCIT:C126430 NCIT:C2875 PMID:16020420 PMID:33612605 SNOMED:64379006 UMLS:C0232462 MIO:00121 A reduced desire to eat. [url:http://purl.obolibrary.org/obo/HP_0004396] poor appetite anorexia decreased appetite inappetence loss of appetite no appetite poor appetite PMID:29083808 SNOMED:110299009 MIO:00122 poor oral hygiene HP:0000989 ICD11:EC90 MSH:D011537 NCIT:C3344 PMID:11182180 PMID:5565435 SNOMED:418290006 UMLS:C0033774 MIO:00123 Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus. [url:http://purl.obolibrary.org/obo/HP_0000989] pruritus itching itchy skin pruritis skin itching NCIT:C119216 PMID:29083808 UMLS:C1336953 MIO:00124 Wheezing and rales are common if the patient has developed pulmonary edema.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] Abnormal breath sounds (crackles) heard on auscultation, indicating inflammation, fluid, or infection of the lung. [url:http://purl.obolibrary.org/obo/NCIT_C119216] rales pulmonary crackles pulmonary crepitations pulmonary rales HP:0000975 ICD11:EE00 NCIT:C36172 PMID:11182180 PMID:26695479 PMID:30807351 SNOMED:415691001 UMLS:C0020458 MIO:00125 A watery secretion by the sweat glands that is primarily composed of salt, urea and minerals. sweating diaphoresis hyperhidrosis sweats HP:0001279 ICD11:MG45.0 MSH:D013575 NCIT:C35053 PMID:29243857 PMID:30807351 SNOMED:271594007 UMLS:C0039070 MIO:00126 Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow. [url:http://purl.obolibrary.org/obo/HP_0001279] syncope cardiac syncope fainting fainting spell HP:0002789 MSH:D059246 NCIT:C50767 PMID:29083808 PMID:8893117 SNOMED:271823003 UMLS:C0231835 MIO:00127 Tachypnea is not uncommon.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] Abnormal increase of rate of breathing. [url:http://purl.obolibrary.org/obo/NCIT_C5076] tachypnea fast breathing increased respiratory rate increased respiratory rate or depth of breathing polypnea HP:0000360 ICD11:MC41 MSH:D014012 NCIT:C50772 PMID:12486425 SNOMED:162349004 UMLS:C0040264 MIO:00128 Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation. [url:http://purl.obolibrary.org/obo/HP_0000360] tinnitus ringing in ears ringing in the ears tinnitus aurium HP:0002321 ICD11:MB48.0 MSH:D014717 NCIT:C38057 PMID:11182180 SNOMED:399153001 UMLS:C0012833 MIO:00129 A feeling of movement, a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo). Vertigo is medically distinct from dizziness, lightheadedness, and unsteadiness. [url:http://purl.obolibrary.org/obo/NCIT_C38057] vertigo dizziness dizzy spell lightheadedness HP:0002013 ICD11:MD90.1 MSH:D014839 NCIT:C3442 PMID:11182180 PMID:30807351 PMID:3458080 SNOMED:249497008 UMLS:C0042963 MIO:00130 Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions. [url:http://purl.obolibrary.org/obo/HP_0002013] vomiting NCIT:C50809 PMID:11182180 MIO:00131 The property of lacking physical strength. [url:http://purl.obolibrary.org/obo/NCIT_C50809] weakness NCIT:C78718 PMID:29083808 UMLS:C0043144 MIO:00132 Wheezing and rales are common if the patient has developed pulmonary edema.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema. [url:http://purl.obolibrary.org/obo/NCIT_C78718] wheezing wheeze NCIT:C20993 UMLS:C1516602 MIO:00133 Any evaluation or assessment tool used to ascertain a patient's condition or diagnosis. [url:http://purl.obolibrary.org/obo/NCIT_C20993] assessment tool classification systems clinical assessment tool clinical or research assessment tool diagnostic tool research or clinical assessment tool EFO:0004298 NCIT:C122008 UMLS:C3854344 MIO:00134 Tests and assessments pertaining to the cardiovascular system. [url:http://purl.obolibrary.org/obo/NCIT_C122008] cardiovascular examination cardiovascular measurement NCIT:C16502 MIO:00135 Any method that uses a visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. [url:http://purl.obolibrary.org/obo/NCIT_C16502] diagnostic imaging NCIT:C25294 MIO:00136 Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting. [url:http://purl.obolibrary.org/obo/NCIT_C25294] laboratory test lab exam lab test lab tests laboratory procedure laboratory tests NCIT:C20989 MIO:00137 A systemic evaluation of the body and its functions using visual inspection, palpation, percussion and auscultation. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment. [url:http://purl.obolibrary.org/obo/NCIT_C20989] physical examination general examination physical assessment physical exam MIO:00138 myocardial infarction mimics NMR:1000859 MIO:00139 A molecules is a fundamental component of a chemical compound that is the smallest part of the compound that can participate in a chemical reaction. [ MSI : NMR ] [url:http://nmrML.org/nmrCVNMR:1000859] molecular factor molecular factors molecule MIO:00140 Biochemical factors other than factors about molecules and cells. other biochemical factors EFO:1000883 PMID:5411049 MIO:00141 Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction. [url:http://www.ebi.ac.uk/efo/EFO_1000883] coronary thrombosis coronary artery thrombosis coronary thrombus coronary vessel thrombotic disease thrombotic disease of coronary vessel EFO:0004225 PMID:380605 MIO:00142 Sudden coronary artery smooth muscle contraction leading to lumen constriction and decreased blood flow. [url:http://www.ebi.ac.uk/efo/EFO_0004225] coronary vasospasm coronary artery spasm coronary artery vasospasm coronary spasm DCM:122363 PMID:10960209 MIO:00143 Plaque ulceration with a tear detected in a fibrous cap. [url:http://dicom.nema.org/resources/ontology/DCM/122363] plaque rupture plaque disruption plaque fissuring rupture of coronary plaque rupture of plaque ruptured plaque HP:0006702 ICD11:BA82 NCIT:C165532 PMID:10800297 PMID:1764739 PMID:7661390 PMID:7732214 PMID:8022067 MIO:00144 The spontaneous occurrence of a dissection of the coronary artery. The clinical recognition of this phenomenon has increased as coronary angiography is becoming more commonly used in the treatment of acute coronary syndrome. The etiology of the condition has not been fully elucidated, but the mean age of presentation is 30-45 years, more than 70% are women, and 30% of cases occur in the peripartum period. [url:http://purl.obolibrary.org/obo/NCIT_C165532] spontaneous coronary artery dissection SCAD MIO:00145 other clinical factors HP:0000118 MIO:00146 A phenotype that shows detectable differences from normal. [url:http://purl.obolibrary.org/obo/HP_0000118] phenotypic abnormality abnormal phenotype MIO:00147 Factors about treatment. treatment factor therapeutic factor therapeutic factors treatment factors SCDO:0000236 MIO:00148 Meteorological conditions, including temperature, precipitation, and wind, that characteristically prevail in a particular region; includes regions of the earth having particular meteorological conditions. [url:http://purl.obolibrary.org/obo/SCDO_0000236] climate weather ENVO:02500036 MIO:00149 An environmental system process that results in the introduction of contaminants into an environment. [url:http://purl.obolibrary.org/obo/ENVO_02500036] environmental pollution GAZ:00000448 MIO:00150 A reference to a place on the Earth, by its name or by its geographical location. [url:http://purl.obolibrary.org/obo/GAZ_00000448] geographic location geographic region region MIO:00151 distance between home and hospital ECTO:0010000 MIO:00152 A exposure event involving the interaction of an exposure receptor to quality. [url:http://purl.obolibrary.org/obo/ECTO_0010000] exposure to environmental quality NCIT:C79660 MIO:00153 The male genetic material of a seed plant contained in the anther, usually appearing as fine grains or dust.[url:http://purl.obolibrary.org/obo/NCIT_C79660] exposure to pollen airborne pollen NCIT:C17140 MIO:00154 Exposure to tobacco smoke products among individuals who do not smoke. This can result from sharing space with a smoker or from placental transfer from mother to fetus. [url:http://purl.obolibrary.org/obo/NCIT_C17140] passive smoke exposure environmental tobacco smoke environmental tobacco smoke exposure exposure to environmental tobacco smoke passive smoke exposure passive smoking DICOM:110828 OMIT:0003143 MIO:00155 Velocity of blood flow based on Doppler measurements. [url:http://dicom.nema.org/resources/ontology/DCM/110828] blood flow velocity flow propagation velocity flow velocity NCIT:C124142 MIO:00156 A medical imaging test that involves injecting contrast media into the heart's ventricle(s) to determine a patient's cardiac function. [url:http://purl.obolibrary.org/obo/NCIT_C124142] cardiac ventriculography radionuclide ventriculography ventriculography DICOM:130677 MIO:00157 This is the third strain component whose direction is orthogonal to both the radial and longitudinal. One way to see it is the reduction of the circumference of the LV chamber as seen in a short-axis view. The annular shape of the LV wall will change and become thicker (radial strain) with a smaller inner circle (circumferential strain). In a normal heart, the circumferential strain or positives negative as measured from end-diastole. [url:https://en.wikipedia.org/wiki/Regional_function_of_the_heartCircumferential_strain_%28Ecc%29] circumferential strain E(cc) Ecc circumferential lagrangian strain NCIT:C100086 MIO:00158 The contribution of blood supply from the right or left vessel system to the posterior descending artery. (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C100086] coronary artery dominance COARTDOM PMID:21514503 MIO:00159 Diastolic deceleration time (DDT) was measured from the peak diastolic velocity to the point of intercept of initial decay slope with baseline. [url:https://pubmed.ncbi.nlm.nih.gov/21514503/] diastolic deceleration time DDT deceleration time of diastolic flow velocity diastolic velocity deceleration time NCIT:C120919 MIO:00160 The pressure within the left ventricle of the heart at the end of the period when the chambers of the heart refill with blood and just before the contraction begins. [url:http://purl.obolibrary.org/obo/NCIT_C120919] left ventricular end-diastolic pressure LVEDP left ventricular end diastolic pressure SNOMED:250932006 MIO:00161 In cardiovascular physiology, end-diastolic volume (EDV) is the volume of blood in the right and/or left ventricle at end load or filling in (diastole) or the amount of blood in the ventricles just before systole. [url:https://en.wikipedia.org/wiki/End-diastolic_volume] left ventricular end-diastolic volume LV cavity size end-diastolic LVEDV end-diastolic volume left ventricular cavity size end-diastolic left ventricular end diastolic volume left ventricular end-diastolic cavity size SNOMED:250931004 MIO:00162 End-systolic volume (ESV) is the volume of blood in a ventricle at the end of contraction, or systole, and the beginning of filling, or diastole. ESV is the lowest volume of blood in the ventricle at any point in the cardiac cycle. The main factors that affect the end-systolic volume are afterload and the contractility of the heart. [url:https://en.wikipedia.org/wiki/End-systolic_volume] left ventricular end-systolic volume LV cavity size end-systolic LVESV left ventricular cavity size end-systolic left ventricular end systolic volume left ventricular end-systolic cavity size NCIT:C35462 MIO:00163 The left ventricular volume calculated as the difference between the epicardium delimited volume and the left ventricular chamber volume. [ url:http://purl.obolibrary.org/obo/NCIT_C35462] left ventricular mass LV mass DICOM:125202 SNOMED:250909007 MIO:00164 The average of all scored (non-zero) Left Ventricle segment wall motion scores. [url:http://dicom.nema.org/resources/ontology/DCM/125202] left ventricular wall motion score index LV wall motion score index WMSI left ventricular wall motion index wall motion score index DICOM:130670 MIO:00165 Lagrangian strain parallel to the reference contour (i.e. in the longitudinal direction) calculated as: SL(t)=(L(t) -L0)/L0, where L(t) is the length at a given point t in time and L0 is the reference length at the reference time t0.Strain values are negative with shortening. Due to the common convention of using end-diastole as the t0 reference time, echocardiography strain values are typically negative. [url:http://dicom.nema.org/resources/ontology/DCM/130670] longitudinal strain EII longitudinal lagrangian strain PMID:9639373 MIO:00166 Myocardial blush grade (MBG) is an angiographic measure of myocardial perfusion.[url:https://pubmed.ncbi.nlm.nih.gov/12695301/] Myocardial blush grades were defined as follows: 0, no myocardial blush or contrast density; 1, minimal myocardial blush or contrast density; 2, moderate myocardial blush or contrast density but less than that obtained during angiography of a contralateral or ipsilateral non–infarct-related coronary artery; and 3, normal myocardial blush or contrast density, comparable with that obtained during angiography of a contralateral or ipsilateral non–infarct-related coronary artery. [url:https://pubmed.ncbi.nlm.nih.gov/9639373/] myocardial blush grade MBG DICOM:130675 MIO:00167 Lagrangian strain in the wall of a cavity perpendicular to the longitudinal strain and towards the center of the cavity. [url:http://dicom.nema.org/resources/ontology/DCM/130675] radial strain Err radial lagrangian strain MIO:00168 Strain is defined as the fractional or percentage change in an objects dimension in comparison to the object’s original dimension. [url:https://en.wikipedia.org/wiki/Speckle_tracking_echocardiographyStrain] strain S MIO:00169 Strain rate is the rate of deformation. In ultrasound it is usually measured from the velocity gradient SR = (v2 - v1)/L where v2and v1 are the myocardial velocities at two different points, and L is the instantaneous distance between them. [url:https://en.wikipedia.org/wiki/Strain_rate_imaging] strain rate SR NCIT:C100021 MIO:00170 A grading system for coronary blood flow based on the classification developed by the Thrombolysis in Myocardial Infarction Group. It classifies coronary blood flow into four classes based upon the angiographic appearance of the blood vessels. [url:http://purl.obolibrary.org/obo/NCIT_C100021] thrombolysis in myocardial infarction flow TFG TIMI flow TIMI grade TIMI grade flow TIMI-flow TIMIFLOW thrombolysis in myocardial infarction grade flow NCIT:C161615 PMID:26369341 MIO:00171 TIMI coronary thrombus grade TIMI thrombus grade Thrombolysis In Myocardial Infarction thrombus grade timi coronary thrombus grade NCIT:C116144 MIO:00172 The minimum diameter of the inside of a blood vessel (lumen) derived quantitatively in a single view. [url:http://purl.obolibrary.org/obo/NCIT_C116144] minimum vessel lumen diameter minimum vessel lumen diameter minldiam NCIT:C130061 MIO:00173 A method of ultrasound imaging that uses pulsed wave Doppler signals to depict tissue motion direction and velocity in color images that are superimposed over normal, 2D images. [url:http://purl.obolibrary.org/obo/NCIT_C130061] color tissue doppler ultrasound mode color flow tissue doppler mode color tissue doppler mode color tissue doppler ultrasound mode NCIT:C168098 MIO:00174 A history of having had an abnormal chest radiograph. [url:http://purl.obolibrary.org/obo/NCIT_C168098] abnormal chest radiograph abnormal chest radiograph abnormal chest x-ray patient_had_abnormal_chest_x-ray NCIT:C32874 MIO:00175 The wall that separates the left and right ventricles of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C32874] interventricular septum heart, ventricular septum interventricular septal wall interventricular septum ventricular septum NCIT:C38712 MIO:00176 The acetate salt of the radioisotope carbon-11. Although the mechanism is unclear, carbon-11 acetate preferentially accumulates in tumor tissue, serving as a tracer for imaging tumors with positron emission tomography (PET). [url:http://purl.obolibrary.org/obo/NCIT_C38712] 11C-acetate uptake uptake of 11C-acetate MIO:00177 123I-BMIPP uptake uptake of 123I-BMIPP MIO:00178 99mTc-pyrophosphate uptake uptake of 99mTc-pyrophosphate NCIT:C1419 MIO:00179 Sestamibi is a large synthetic molecule of the isonitrile family, which can be labeled with Tc99m. It passes through cells membranes passively, collecting in cells with large numbers of mitochondria. It is often used for imaging of the thyroid and parathyroid. [url:http://purl.obolibrary.org/obo/NCIT_C1419] 99mTc-sestamibi uptake uptake of 99mTc-sestamibi NCIT:C87410 MIO:00180 A radiopharmaceutical consisting of tetrofosmin, composed of two bidentate diphosphine ligands chelating the metastable radioisotope technetium Tc-99 (99mTc), with potential imaging activity upon SPECT (single photon emission computed tomography). Upon administration, technetium Tc 99m tetrofosmin is preferentially taken up by, and accumulates in, myocardial cells. Upon imaging, myocardial cells can be visualized and changes in ischemia and/or perfusion can be detected. [url:http://purl.obolibrary.org/obo/NCIT_C87410] 99mTc-tetrofosmin uptake uptake of 99mTc-tetrofosmin PMID:17388105 MIO:00181 Adt was calculated as the time between peak A velocity and the upper deceleration slope extrapolated to zero baseline.[PMID:17388105] A wave deceleration time Adt PMID:1854492 MIO:00182 ratio of peak velocities with atrial filling to early diastolic filling [PMID:1854492] A/E wave ratio MIO:00183 Area of diastolic wall motion abnormality was expressed as percentages of the LV cavity size in end-diastole. abnormal diastolic wall motion PMID:3719599 MIO:00184 The echo parameters evaluated were: left ventricular diastolic diameter, left ventricular percent fractional shortening and the mitral valve E point septal separation. The combination of these three echo criteria was defined as an echo-index, which was considered abnormal if at least two of the three single parameters were pathological.[PMID:3719599] abnormal echo-index PMID:7722131 MIO:00185 Two distinct abnormal flow patterns can be recognized: apical rotating flow and vortex ring formation.[PMID:7722131] abnormal spatial patterns of mitral inflow MIO:00186 aneurysmal lesion MIO:00187 angle between the left anterior descending and the left main coronary artery MIO:00188 apical regional wall stress DICOM:130523 MIO:00189 The angle about the center of rotation for a rotating object. [url:http://dicom.nema.org/resources/ontology/DCM/130523] apical rotation angle MIO:00190 apical wall thickness PMID:28025463 MIO:00191 Area change ratio (ACR) represents the changes in the endocardial surface area.[PMID:28025463] area change ratio ACR PMID:9693164 MIO:00192 The atrial emptying index, an estimate of early left ventricular (LV) filling properties, was calculated from the posterior aortic wall motion by means of a digitizer and a computer as previously described.[PMID:9693164] atrial emptying index PMID:22582478 MIO:00193 Atrioventricular plane displacement is a well-accepted method for assessment of left ventricular systolic function.[PMID:22582478] atrioventricular plane displacement PMID:28247458 MIO:00194 Average global longitudinal peak systolic strain (GLPSavg) is a proven parameter which shows LV systolic functions. GLPSavg and the extent of infarction have been reported to be closely linked with ischemic heart diseases which are associated with prognosis in heart failure with ischemic origin.[PMID:28247458] average global longitudinal peak systolic strain GLPSavg PMID:10421592 MIO:00195 Average systolic peak velocity (ASV) is a parameter of coronary blood flow velocity (CFV).[PMID:10421592] average systolic peak velocity ASV PMID:23476044 MIO:00196 The backward expansion wave (BEW) was derived from wave intensity analysis of phasic coronary pressure and velocity in the infarct-related artery, whereas mean values were used to calculate hyperemic microvascular resistance.[PMID:23476044] backward expansion wave BEW PMID:24550440 MIO:00197 Bimodal: defined as 2 peak shapes.[PMID:24550440] bimodal shape pattern of coronary blood flow PMID:16376766 MIO:00198 Biphasic response was present when infarcted region showed improvement of contractility on the first dose of dipyridamole followed by worsening of contractility of the same segments on the second dose of dipyridamole.[PMID:16376766] biphasic response MIO:00199 A newer approach to using these x-rays for evaluating heart health takes the ratio of heart area to chest area and has been called the two-dimensional cardiothoracic ratio.[url:https://en.wikipedia.org/wiki/Cardiomegaly#Cardiothoracic_ratio] cardiothoracic ratio PMID:31387432 MIO:00200 Circumferential uniformity ratio estimate (CURE) was calculated per slice with subsequent averaging across basal, midventricular, and apical slices and then expressed as global myocardial values, as described previously.[PMID:31387432] circumferential uniformity ratio estimate CURE PMID:18930629 MIO:00201 the time delay from end-systolic to peak strain divided by the RR interval [PMID:18930629] corrected time to peak strain MIO:00202 contrast-flow QFR (cQFR), fixed-flow QFR (fQFR) cQFR-fQFR MIO:00203 cutoff occlusion pattern PMID:12381081 MIO:00204 The cyclic variation (CV) of integrated backscatter (IBS) reflects intrinsic contractile performance [PMID:12381081] cyclic variation of ultrasonic integrated backscatter PMID:12196333 MIO:00205 Delayed hyperenhancement was defined as being present if signal intensity on late images was higher than mean+2 SD of the 9 remote normal segments 10 minutes after contrast injection. [PMID:12196333] delayed hyperenhancement MIO:00206 dense scar area MIO:00207 diameter of target lesion PMID:10841232 MIO:00208 time-averaged diastolic peak velocity divided by time-averaged systolic peak velocity [PMID:10841232] diastolic to systolic velocity ratio MIO:00209 discordance in defect size between 123I-BMIPP uptake and thallium-201 uptake PMID:27703973 MIO:00210 septal peak velocities of early (E)/(septal corners of the mitral annular velocity (E') * peak mitral annular systolic velocity (S')) ratio [PMID:27703973] E/(E' X S') ratio PMID:20846606 MIO:00211 Early diastolic circumferential strain rate (Ecc/s) was defined as the slope divided by the duration from end-systole to mid-diastole.[PMID:20846606] early diastolic circumferential strain rate Ecc/s PMID:31973603 MIO:00212 Early systolic lengthening (ESL) may occur in ischemic myocardial segments with reduced contractile force. [PMID:31973603] early systolic lengthening ESL PMID:15541245 MIO:00213 End-diastolic sphericity index was calculated as the ratio of the major to the minor semi-axis of the left ventricle at end-diastole.[PMID:15541245] end-diastolic sphericity index PMID:15093888 MIO:00214 The EDWT was assessed at the center of each myocardial segment from the leading endocardial edge to the leading epicardial edge as the mean of three measurements. Dysfunctional segments were categorized as segments with an EDWT <11 mm and an EDWT >=11 mm.[PMID:15093888] end-diastolic wall thickness EDWT MIO:00215 endocardial scar extension PMID:18930629 MIO:00216 End-systolic strain was defined to be the magnitude of deformation from the end-diastolic reference time point to the end of systole (i.e., aortic valve closure).[PMID:18930629] end-systolic strain PMID:27852304 MIO:00217 EAT thickness was measured on the free wall of the right ventricle (RV) in a still image at end diastole on the parasternal long-axis view. EAT thickness was measured at the point on the free wall of the RV at which the ultrasound beam was oriented perpendicularly to the aortic annulus.[PMID:27852304] epicardial adipose tissue thickness EAT thickness PMID:17426322 MIO:00218 Total epicardial fat volume was obtained after the summation of data of all slices.[PMID:17426322] epicardial adipose tissue volume epicardial fat volume NCIT:C32555 MIO:00219 A thin layer of fibrous tissue capable of stretching and contracting. It is part of the tunica media of the blood vessels.[url:http://purl.obolibrary.org/obo/NCIT_C32555] external elastic membrane area MIO:00220 fade-out type of infarct-related artery MIO:00221 The uptake of 18F-FDG by tissues is a marker for the tissue uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. After 18F-FDG is injected into a patient, a PET scanner can form two-dimensional or three-dimensional images of the distribution of 18F-FDG within the body.[url:https://en.wikipedia.org/wiki/Fluorodeoxyglucose_(18F)] FDG uptake uptake of 18F-FDG PMID:26088511 MIO:00222 Fibrous cap thickness was estimated by measuring the thinnest signal-rich zone separating the lipid content from the vessel lumen in the entire stenosis (in um).[PMID:26088511] fibrous cap thickness PMID:17634879 MIO:00223 First-pass hypoenhancement was determined as being present if the percent signal intensity increase was less than a mean of -2 SD of the remote normal myocardium. [PMID:17634879] first-pass hypoenhancement PMID:30182321 MIO:00224 FWRVLS as the average of three free wall segments.[PMID:30182321] free wall right ventricular longitudinal strain FWRVLS PMID:23614917 MIO:00225 The functional integrated bi-myocardial tissue Doppler (FIT) index was defined as (s'-T)/(E/e'). [PMID:23614917] functional integrated bi-myocardial tissue Doppler index FIT index PMID:26100310 MIO:00226 Videodensitometric parameter G(max)/T(max) was calculated to characterize myocardial perfusion, derived from the plateau of grey-level intensity (G(max)), divided by the time-to-peak intensity (Tmax). [PMID:26100310] G(max)/T(max) MIO:00227 global area strain PMID:31440976 MIO:00228 The heart/mediastinum count (H/M) ratio was determined from the anterior planar delayed 123I-MIBG image.[PMID:31440976] heart/mediastinum count ratio H/M ratio PMID:31912991 MIO:00229 Modeled HFV was automatically calculated by the AngioPlus system and computation of QFR was performed by two operators who were blinded to clinical data.[PMID:31912991] hyperemic flow velocity PMID:7977113 MIO:00230 Both inward wall motion and wall thickening were evaluated, and each segment was graded as 1 = normal or hyperkinetic, 2 = hypokinetic, 3 = akinetic, and 4 = dyskinetic. [PMID:7977113] hyperkinetic segments PMID:26259581 MIO:00231 Hypointense cores (HIC) subjects were identified as those with eight or more contiguous nearest-neighbor hypointense pixels in the infarct territory that are present in every frame of a given short-axis set of cine steady-state free precession (bSSFP) CMR images.[PMID:26259581] hypointense cores PMID:2741826 MIO:00232 Indium-111 antimyosin uptake was evaluated for count density index (count density of infarct zone/left lung count density) in the left anterior oblique projection, in which the infarction zone was well displayed in all patients.[PMID:2741826] indium-111 antimyosin uptake uptake of indium-111 antimyosin PMID:19479315 MIO:00233 Infarct severity was defined as the mean sectorial tracer uptake in the IRA territory.[PMID:19479315] infarct severity MIO:00234 infarct zone wall motion score index MIO:00235 The time of infarct-related artery patency. infarct-related artery open-up time MIO:00236 inferior annular systolic velocity MIO:00237 initial postsystolic to systolic strain rate ratio MIO:00238 The IMT was the average of the discrete maximum separately for both common and both internal carotid arteries. intima-to-media wall thickness of internal carotid artery IMT PMID:32227520 MIO:00239 In the scar core, islets of heterogeneous myocardium were revealed. They were defined as areas of potentially viable myocardium within or adjacent to the core scar.[PMID:32227520] islets of heterogeneous myocardium PMID:22209631 MIO:00240 Late defects were similarly defined when identified on the late scan.[PMID:22209631] late defect NCIT:C99970 MIO:00241 The diameter across the left atrium measured at the end of systole. (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C99970] left atrial dimension PMID:22696494 MIO:00242 left atrial fractional change = cyclic change/left atrial maximal volume [PMID:22696494] left atrial fractional change MIO:00243 left atrial reservoir strain CMO:0001191 MIO:00244 A measurement of the extent of a two-dimensional plane through the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter.[CMO:0001191] left ventricle end-diastolic area CMO:0001192 MIO:00245 A measurement of the extent of a two-dimensional plane through the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter.[CMO:0001192] left ventricle end-systolic area PMID:19026291 MIO:00246 LV conic index was defined as LV end-diastolic volume (LVEDV) divided by the volume of a cone whose bottom diameter is the internal diameter of the mitral annulus and height is the LV long axis) [PMID:19026291] left ventricular conic index LV conic index PMID:19460838 MIO:00247 Based on hemodynamic and echocardiographic data, end-diastolic and systolic meridional wall stresses were calculated as follows: WS = 0.334 脳 P(LVID)/WT(1 + WT/LVID), where WS is wall stress, P is LV pressure [i.e., peak systolic pressure or end-diastolic pressure (EDP), which was obtained during cardiac catheterization], LVID is left ventricular internal dimension, and WT is wall thickness.[PMID:19460838] left ventricular end-diastolic wall stress PMID:19460838 MIO:00248 Based on hemodynamic and echocardiographic data, end-diastolic and systolic meridional wall stresses were calculated as follows: WS = 0.334 脳 P(LVID)/WT(1 + WT/LVID), where WS is wall stress, P is LV pressure [i.e., peak systolic pressure or end-diastolic pressure (EDP), which was obtained during cardiac catheterization], LVID is left ventricular internal dimension, and WT is wall thickness.[PMID:19460838] left ventricular end-systolic wall stress PMID:33160891 MIO:00249 LVGFI = (stroke volume/[mean cavity volume + myocardial volume]) 脳 100 [PMID:33160891] left ventricular global functional index LVGFI PMID:26206466 MIO:00250 LV twist was calculated as the net difference of apical and basal rotation at isochronal time points for each sublayer at both rest and peak-dose stages.[PMID:26206466] left ventricular sublayer twist LV twist EFO:0008206 MIO:00251 quantification of some aspect of the systolic function of the left cardiac ventricle such as ventricular fractional shortening or systolic dysfunction [url:http://www.ebi.ac.uk/efo/EFO_0008206] left ventricular systolic function LV systolic function PMID:15637484 MIO:00252 LV Tei index was measured at the time of admission as (a - b)/ b , where a is the interval between cessation and onset of mitral filling flow and interval b is the aortic flow ejection time.[PMID:15637484] left ventricular Tei index PMID:30591753 MIO:00253 Left ventricular (LV) torsion was defined as the net difference of LV rotation at the basal and apical planes (in degrees). left ventricular torsion LV torsion MIO:00254 length of left main coronary artery PMID:29390391 MIO:00255 The length of lipid pool was measured as consecutive longitudinal length of lipid pool at culprit plaque assessed by OCT. PMID:29390391] length of lipid pool MIO:00256 length of the culprit vessel PMID:2656822 MIO:00257 Lesion length was scored as the length of that portion of the stenosis that had >=30% reduction in luminal diameter using the adjacent normal vessel diameter as a yardstick or unit.[PMID:2656822] lesion length MIO:00258 Lipid index was calculated as the average of lipid arc multiplied by lipid length. lipid index PMID:31329854 MIO:00259 Assessment of LAS was performed in a blinded core-laboratory measuring the systolic shortening between the epicardial apical border and the middle of a line connecting the origins of the mitral leaflets.[PMID:31329854] long-axis strain PMID:31074229 MIO:00260 The LSant was defined as the mean peak systolic longitudinal strain of the 11 segments supplied by left anterior descending (LAD) and calculated by the operator using the bull's eye plot image.[PMID:31074229] longitudinal strain of left anterior descending artery territory LSant PMID:28673476 MIO:00261 average longitudinal strain of segments using wall motion score index (WMSI) scores >/=2 [PMID:28673476] longitudinal strain-wall motion score index MIO:00262 low-dose dobutamine stress cine magnetic resonance imaging PMID:2656822 MIO:00263 A stenosis was judged to be "rough" ifits luminal edge was irregular, or had a "sawtooth" component. A stenosis was judged "smooth" if its edge was smooth. Luminal edge was judged only if anterograde flow visualized the vessel edge well.[PMID:2656822] luminal roughness MIO:00264 material stiffness in fiber direction at end-systole PMID:26003018 MIO:00265 lesions with a maximal lipid core burden index over any 4-mm length [PMID:26003018] maxLCBI4mm PMID:11801696 MIO:00266 For each infarct zone, the following parameters were determined: mean 99mTc-sestamibi activity value, calculated as the sum of the activity in the related segments divided by 9; extent of infarct, expressed as the total number of segments with abnormal uptake.[PMID:11801696] mean activity of the infarct zone DICOM:130673 MIO:00267 The standard deviation of the time to peak longitudinal strain value for different myocardial segments. Typically assessed over 18-segments of the left ventricle.[url:http://dicom.nema.org/resources/ontology/DCM/130673] mechanical dispersion PMID:25424161 MIO:00268 Infarct size and acute MI extent and transmurality were analyzed alone and together, using the variable named "MET-AMI".[PMID:25424161] MET-AMI PMID:12114092 MIO:00269 A segment with no resting wall thickening was defined as viable if the contrast opacification score was 1 or 2.[PMID:12114092] microvascular integrity MIO:00270 minimum stent area PMID:23791116 MIO:00271 Mitral annular displacement (MAD) was defined as the part of the displacement curve corresponding to the interval from the onset of the QRS complex to the end of the T wave on the electrocardiogram. [PMID:23791116] mitral annular displacement MAD PMID:22305962 MIO:00272 Tenting area, defined as the area enclosed between the annular plane and the mitral leaflets in mid-systole.[PMID:22305962] mitral tenting area MIO:00273 myocardial blood volume PMID:10337544 MIO:00274 The peak myocardial velocity gradient assessed in both walls was defined by: MVG=(Vendo-Vepi)/T, with MVG: myocardial velocity gradient, Vendo: peak endocardial excursion velocity, Vepi: peak epicardial excursion velocity, T: wall thickness. [PMID:10337544] myocardial velocity gradient PMID:33010853 MIO:00275 MW was calculated from a combination of 2D left ventricular (LV) longitudinal strain data (as described above) and a noninvasively estimated LV pressure curve, using the commercially available machine and workstation described above from GE.[PMID:33010853] myocardial work MIO:00276 nearby bifurcation MIO:00277 necrotic core volume NCIT:C79714 MIO:00278 A radiopharmaceutical composed of ammonia labeled with the radioisotope nitrogen N 13 that can be used, during positron emission tomography (PET), as a blood flow imaging agent and potentially as a tumor imaging agent. Upon intravenous administration, ammonia N 13 distributes to various organs in the body, such as the myocardium, liver, kidneys and brain. This agent is taken up by cells and is retained following conversion to glutamine N 13 by glutamine synthetase (GS). Upon PET, organ perfusion and the presence of cancer cells can be assessed. GS, an enzyme that catalyzes the synthesis of glutamine from glutamate and ammonia, is overexpressed in a variety of cancers and plays a key role in cancer cell proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C79714] nitrogen-13 ammonia uptake MIO:00279 heart function in the noninfarct zone noninfarct zone function MIO:00280 normalized time delay MIO:00281 number of segments with reduced longitudinal strain PMID:9811174 MIO:00282 The opacification index was calculated by dividing the sum of opacification score by the number of segments within left anterior descending coronary artery territory.[PMID:9811174] opacification index MIO:00283 peak atrial longitudinal strain PMID:9768708 MIO:00284 The peak gray scale ratio (PSGR) within the RA normalized to the peak gray scale of the left circumflex artery area with subtraction of the baseline using the following formulas: PGSR =A/X, A =BSPGS in RA, and X =BSPGS in LCX, where PGSR is the peak gray scale ratio, BSPGS the baseline-subtracted peak gray scale value after opening the IRA and LCX the region of interest in the territory of the left circumflex coronary artery.[PMID:9768708] peak gray scale ratio PSGR PMID:18930629 MIO:00285 Peak strain was defined to be the lowest strain value obtained for the longitudinal direction.[PMID:18930629] peak strain MIO:00286 peak systolic longitudinal strain MIO:00287 peak systolic strain rate PMID:23764484 MIO:00288 The amounts of penumbra were divided by the total amount of enhanced area to calculate the proportion of the penumbra within the total enhanced area.[PMID:23764484] penumbra size PMID:3942074 MIO:00289 The percentage of abnormally contracting regions (%ACR) was calculated as the proportion of the 8 regions where regional ejection fraction (EF) was more than 2 standard deviations below the mean for that region in a group of 15 normals.[PMID:3942074] percent abnormally contracting regions PMID:10702647 MIO:00290 Percent (%) fixed defect was calculated as a ratio of number of pixels in fixed defect area to that in whole left ventricular area. [PMID:10702647] percent fixed defect PMID:1854492 MIO:00291 The percentage of left ventricular filling contributed by atrial systole, estimated as the time velocity integral of the A wave divided by the total time velocity integral * 100 (A%).[PMID:1854492] percentage of filling with atrial systole PMID:26341122 MIO:00292 The duration of longitudinal systolic lengthening (when present) was measured, as previously described, as the time interval from end-diastole (peak R in the QRS complex) to the return to zero strain and was reported as a percentage of systolic duration (SL % duration). [PMID:26341122] percentage of systolic duration PMID:20829210 MIO:00293 Perfused capillary density (PCD) was calculated by measuring total length of perfused capillaries divided by the image area.[PMID:20829210] perfused capillary density PCD PMID:9024727 MIO:00294 Perfusion defect score was quantitatively calculated by measuring the area between the lower limit of normal values ({ 2 SD) and the actual circumferential profile in 6 short-axis slices.[PMID:9024727] perfusion defect score PMID:29866393 MIO:00295 Pericoronary adipose tissue (PCAT) is the vessel surrounding layer of epicardial adipose tissue (EAT), without anatomical borders but different function and morphology.[PMID:29866393] pericoronary adipose tissue PCAT MIO:00296 pharmacologic dose at ischemia PMID:15165914 MIO:00297 If the normalized delay value was >1.2, we considered it indicative of asynchronous (or delayed) contraction and multiplied the magnitude by -1.0 to calculate the phase-corrected magnitude (PCM).[PMID:15165914] phase-corrected magnitude PMID:9833578 MIO:00298 The phase-weighted variation represents the alteration in variation and phase simultaneously and was considered as the parameter of ultrasonic tissue characterization in our study.[PMID:9833578] phase-weighted variation DICOM:122542 MIO:00299 Longitudinal cross sectional area of plaque.[url:http://dicom.nema.org/resources/ontology/DCM/122542] plaque area DICOM:122334 MIO:00300 Area within the EEM occupied by atheroma, regardless of lumen compromise. Plaque plus Media Area = EEM cross-sectional area - vessel lumen cross-sectional area.[url:http://dicom.nema.org/resources/ontology/DCM/122334] plaque plus media cross-sectional area PMID:19632518 MIO:00301 Plaque prolapse was defined as tissue extrusion through the stent strut at post-intervention, and the volume of plaque prolapse was calculated by subtracting lumen volume from stent volume.[PMID:19632518] plaque prolapse MIO:00302 positive finding on stress echocardiography positive stress echocardiography abnormal stress echocardiography PMID:21406475 MIO:00303 Post-systolic strain was defined as the maximal negative strain value occurring after aortic valve closure.[PMID:21406475] post-systolic strain NCIT:C147156 MIO:00304 The amount of time required for the maximum transvalvular pressure gradient to decrease to one half of its initial value.[url:http://purl.obolibrary.org/obo/NCIT_C147156] pressure half-time of pulmonary regurgitation PMID:16474232 MIO:00305 The pressure-derived collateral flow index (CFIp) is assessed by the intracoronary pressure measurement with pressure wire, is significantly influenced by the presence and severity of ischemic microvascular dysfunction in MI, and is associated with the no-reflow phenomenon.[PMID:16474232] pressure-derived collateral flow index CFIp PMID:28673476 MIO:00306 average radial strain of segments using wall motion score index (WMSI) scores >/=2 [PMID:28673476] radial strain-wall motion score index PMID:33289360 MIO:00307 Radiomics signatures were constructed with the selected strongest features to evaluate the myocardial injury severity and predict the recovery of left ventricular (LV) longitudinal systolic myocardial contractility.[PMID:33289360] radiomics signature MIO:00308 reference vessel diameter PMID:16752326 MIO:00309 The regional myocardial contrast index was evaluated as the mean value in dyssynergic left ventricular segments (LVRCstI).[PMID:16752326] regional myocardial contrast index PMID:21514503 MIO:00310 Regional wall motion score in the infarct zone was calculated as the sum of the individual scores of the segments in infarctrelated artery territory.[PMID:21514503] regional wall motion score PMID:24899474 MIO:00311 Relative importance index (RII) for the culprit lesion was calculated by dividing the culprit segment diameter by the total coronary artery diameter. [PMID:24899474] relative importance index RII PMID:12221399 MIO:00312 The perfusion defect size divided by the total endocardial border length defined the relative perfusion defect size (in %) (relMCD). [PMID:12221399] relative perfusion defect size relMCD PMID:9768708 MIO:00313 RA ratio = RA in the territory of left anterior descending coronary artery/total longitudinal cross-sectional area in the apical long axial view of the left ventricle. [PMID:9768708] relative size of the initial risk area RA ratio PMID:3882265 MIO:00314 Residual flow was considered to be present if the artery supplying the area of infarct was subtotally or totally occluded and there were well-developed coronary collaterals to the infarct zone.[PMID:3882265] residual flow PMID:30797759 MIO:00315 Resistive reserve ratio (RRR) is a novel index that expresses the ratio between basal and hyperemic microcirculatory resistance.[PMID:30797759] resistive reserve ratio RRR MIO:00316 response to dobutamine infusion PMID:12376007 MIO:00317 The restrictive mitral inflow pattern was defined as the ratio of early filling velocity to atrial contraction flow velocity > 2 or 1 to 2, but deceleration time </=160 ms.[PMID:12376007] restrictive filling MIO:00318 In human physiology, the atria facilitate circulation primarily by allowing uninterrupted venous flow to the heart during ventricular systole.[url:https://en.wikipedia.org/wiki/Atrium_(heart)#Functional_abnormalities] right atrial function PMID:28977357 MIO:00319 The right ventricular (RV) free wall strain was used as a measure of global RV function, because the septal wall was included in the analysis of left ventricular (LV) global longitudinal strain (GLS), which has previously been shown to be the strongest predictor of arrhythmia in the current cohort.[PMID:28977357] right ventricular free wall strain MIO:00320 The right ventricle receives deoxygenated blood from the right atrium via the tricuspid valve and pumps it into the pulmonary artery via the pulmonary valve, into the pulmonary circulation.[url:https://en.wikipedia.org/wiki/Ventricle_(heart)] right ventricular function PMID:32878921 MIO:00321 RV GLS was assessed in 4-chamber long-axis images.[PMID:32878921] right ventricular global longitudinal strain RV GLS PMID:24186956 MIO:00322 The scar mass was obtained by multiplying the percent scar by left ventricular (LV) mass.[PMID:24186956] scar mass MIO:00323 side branch lesion length MIO:00324 sigma shaped right coronary artery PMID:16765120 MIO:00325 The single-photon emission computed tomographic score index was calculated using the sum of tracer uptakes in dysfunctional segments divided by the number of dysfunctional segments.[PMID:16765120] single-photon emission computed tomographic score index MIO:00326 Sm-6 MIO:00327 stress total perfusion deficit PMID:10562261 MIO:00328 A summed difference (reversibility) score (SDS) was determined by the sum of the difference between the summed stress score (SSS) and summed rest score (SRS) for each segment.[PMID:10562261] summed difference score SDS PMID:10562261 MIO:00329 The summed rest score (SRS) was determined by the sum of scores for each of the 17 segments on stress and rest images, respectively. SRS was categorized as low (0 through 4), intermediate (5 through 8), or high (>8).[PMID:10562261] summed rest score SRS PMID:10562261 MIO:00330 The summed stress score (SSS) was determined by the sum of scores for each of the 17 segments on stress and rest images, respectively. SSS was categorized as low (0 through 4), intermediate (5 through 8), or high (>8).[PMID:10562261] summed stress score SSS PMID:29417419 MIO:00331 Based on the principle of QGS software in measuring wall thickening, a scale of 0 to 3 was applied to score the wall thickening for each segment on the AHA 17-segmentation polar map (0 = normal, 1 = mildly reduced, 2 = moderately to severely reduced, 3 = no thickening) and STS was calculated as the total score of wall thickening from all the 17 segments. STS reveals the global wall thickening abnormalities is the independent predictor of LV mechanical dyssynchrony. [PMID:29417419] summed thickening score STS PMID:24294138 MIO:00332 SAI is the area of systolic portion under the pulse wave curve of a complete cardiac cycle. [PMID:24294138] systolic area index SAI PMID:12639863 MIO:00333 Systolic flow reversal was defined as a coronary flow reversal showing a peak velocity of </= -10 cm/s and a duration of>/= 60 ms during systole. [PMID:12639863] systolic flow reversal PMID:3942074 MIO:00334 Thallium-201 defect index is a quantitative measure of defect size.[PMID:3942074] thallium-201 defect score thallium-201 defect index DICOM:109093 MIO:00335 Imaging after allowing a moderate amount of time for tracer to move from its initial sites of uptake.Example: For Thallium imaging this would correspond to imaging 2-6 hours after injection.[url:http://dicom.nema.org/resources/ontology/DCM/109093] thallium-201 rest-redistribution PMID:15347134 MIO:00336 Percent Tl-201 uptake was calculated by using the following formula: Tl-201 uptake (%) = [Tl-201 counts in the segment/maximal Tl-201 counts in normal segment]*100.[PMID:15347134] thallium-201 uptake Tl-201 uptake PMID:32624460 MIO:00337 The TIMI myocardial perfusion grade (TMPG) was used to assess the tissue level perfusion. [PMID:32624460] TIMI myocardial perfusion grade TMPG DICOM:110827 MIO:00338 Velocity of tissue based on Doppler measurements.[url:http://dicom.nema.org/resources/ontology/DCM/110827] tissue velocity during isovolumic relaxation PMID:20599003 MIO:00339 The PA-TDI duration, defined as the time interval from the initiation of the electrocardiographic P wave on surface electrocardiography to the peak of the A' wave of the atrial tissue Doppler tracing, was measured in 3 cardiac cycles and averaged. [PMID:20599003] total atrial activation time PA-TDI duration PMID:31440976 MIO:00340 The total defect score (TDS) was defined as the sum of the segment defect scores for each patient. [PMID:31440976] total defect score TDS PMID:20185003 MIO:00341 TMDE was defined as any enhancement extent (DE) involving the entire wall thickness, no matter what proportion of the segment involved.[PMID:20185003] transmural relative delayed enhancement extent pattern PMID:29191504 MIO:00342 Right ventricular function was determined by using tricuspid annular plane systolic excursion (TAPSE) which has been described as an accurate method for evaluation of right ventricular function. [PMID:29191504] tricuspid annular plane systolic excursion TAPSE MIO:00343 tricuspid annular velocity BTO:0004041. MIO:00344 Adipose tissue located inside the peritoneal cavity, packed in between internal organs and torso. An excess of visceral fat is known as central obesity, or belly fat, the pot belly or beer belly effect, in which the abdomen protrudes excessively[BTO:0004041]. visceral abdominal adipose tissue PMID:21796358 MIO:00345 global WR (%) = [(mean early cardiac pixel counts - mean delayed cardiac pixel count)/mean early cardiac pixel count] * 100 [PMID:21796358] washout rate WR PMID:26404192 MIO:00346 Pzf is the distal coronary pressure when theoretically the flow in a coronary artery would cease. Pzf is extrapolated from pressure-velocity loops.[PMID:26404192] zero-flow pressure Pzf NCIT:C122038 UMLS:C4055449 MIO:00347 The augmentation pressure divided by the aortic pulse pressure (aortic systolic minus aortic diastolic pressure) multiplied by 100, expressed as a percentage. A complex measure of wave reflection calculated as the ratio of aortic augmentation pressure to pulse pressure, and used as an indirect measure of arterial stiffness. [url:http://purl.obolibrary.org/obo/NCIT_C122038] aortic augmentation index AAUGIX AIaortic aAIx aortic pressure augmentation index CMO:0000179 MIO:00348 The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at either the inner surface or outer surface of the blood vessel wall. [url:http://purl.obolibrary.org/obo/CMO_0000179] blood vessel diameter vessel diameter NCIT:C96950 MIO:00349 A measure of the amount of minerals (mostly calcium and phosphorous) contained in a certain volume of bone. Bone mass measurements are used to diagnose osteoporosis (a condition marked by decreased bone mass), to see how well osteoporosis treatments are working, and to predict how likely the bones are to break. Low bone mass can occur in patients treated for cancer. [url:http://purl.obolibrary.org/obo/NCIT_C96950] bone mineral density BMD bone mass OMIT:0004406 MIO:00350 collateral circulation CCC collateral blood flow coronary collateral circulation SNOMED:251032001 MIO:00351 coronary artery collaterals collateral vessel coronary artery collateral coronary collateral NCIT:C80425 MIO:00352 A quantitative value that is the compilation of assessed size and densities of calcium deposits throughout the coronary tree. [url:http://purl.obolibrary.org/obo/NCIT_C80425] coronary calcium score CAC score coronary artery calcification score coronary artery calcium scoring DICOM:122217 MIO:00353 Coronary flow reserve (CFR) is the maximum increase in blood flow through the coronary arteries above the normal resting volume. Its measurement is often used in medicine to assist in the treatment of conditions affecting the coronary arteries and to determine the efficacy of treatments used. [url:https://en.wikipedia.org/wiki/Coronary_flow_reserve] coronary flow reserve CFR PMID:9777142 MIO:00354 The CTFC assesses infarct-artery coronary blood flow by counting cine frames until there is initial contrast opacification at pre-defined endpoints in the coronary tree depending on the culprit lesion location. The first frame is defined as the one where there is complete filling of the arterydiameter; frame 0 is the prior frame. The TIMI group used a cine angiographic filming rate of 30 frames per second. As cine angiogram rates vary at different laboratories, frame counts can beadjusted to the equivalent of 30 frames per second. [url:https://pubmed.ncbi.nlm.nih.gov/9777142/] corrected TIMI frame count CTFC TIMI frame count TMPFC corrected thrombolysis in MI frame count corrected thrombolysis in myocardial infarction frame count thrombolysis in myocardial infarction (TIMI) myocardial perfusion frame count MIO:00355 diameter of infarct-related artery IRA diameter TVD reference lumen diameter of the IRA target vessel diameter CMO:0002789 MIO:00356 A calculated measurement in which the value of the E wave (that is, the velocity of the blood flow across the mitral valve during passive filling of the left ventricle in early diastole) is divided by the value of the A wave (that is, the velocity of the blood flow across the mitral valve during active filling of the left ventricle caused by atrial contraction in late diastole). [url:http://purl.obolibrary.org/obo/CMO_0002789] E/A wave ratio E wave/A wave ratio E/A ratio Em/Am ratio ratio of mitral peak flow velocity in early diastole to that in late diastole ratio of peak velocity blood flow from gravity in early diastole to peak velocity flow in late diastole CMO:0002862 MIO:00357 The E/E' is a ratio of peak velocity of early diastolic trans-mitral flow (E) to the peak velocity of early diastolic mitral annular motion (E') [url:http://purl.obolibrary.org/obo/CMO_0002862] E/E' wave ratio E wave velocity to E' wave velocity ratio E/Em E/e' ratio of early diastolic mitral flow velocity to early diastolic mitral annular velocity CMO:0002504 MIO:00358 An echocardiographic measurement of the amount of time between the maximum 'E point', that is, the maximum velocity of passive blood flow from the atrium to the ventricle, and the return to baseline at the end of early mitral flow. [url:http://purl.obolibrary.org/obo/CMO_0002504] E wave deceleration time EDT deceleration time of E wave deceleration time of early filling deceleration time of early mitral filling wave mitral E-wave deceleration time mitral deceleration time mitral rapid filling deceleration time mitral valve E-wave deceleration time NCIT:C132332 MIO:00359 The ratio of interstitial fluid volume to total body fluid. [url:http://purl.obolibrary.org/obo/NCIT_C132332] extravascular extracellular volume fraction ECV extracellular volume fraction ERO:0001340 MIO:00360 A physiological assay used to evaluate endothelial dysfunction non-invasively and used for early detection of atherosclerosis and determining the efficacy of treatment. [url:http://purl.obolibrary.org/obo/ERO_0001340] flow-mediated dilation FMD flow-mediated vascular reactivity flow-mediated vasodilation NCIT:C99533 MIO:00361 A lesion-specific measure of stenosis severity within a blood vessel. [url:http://purl.obolibrary.org/obo/NCIT_C99533] fractional flow reserve fractional flow reserve of vessel MIO:00362 The size of myocardial infarction. infarct size extent of infarcted myocardium myocardial infarct size MIO:00363 infarct-related artery patency IRA patency high flow in the infarct-related artery infarct artery recanalization open infarct-related artery patency of IRA patency of infarct related arteries patency of infarct-related artery patency of the infarct-related coronary patent IRA patent infarct artery patent infarct-related artery target vessel reopening EFO:0007117 OMIT:0027534 SNOMED:427312003 MIO:00364 quantification of the thickness of tunica intima and tunica media, the innermost two layers of the wall of the carotid artery, usually by carotid ultrasound [url:http://www.ebi.ac.uk/efo/EFO_0007117] intima media thickness CIMT carotid artery intima media thickness carotid intima-media thickness DICOM:122664 MIO:00365 Delayed hyperenhancement of a tissue observed in an image acquired after injection of contrast media. [url:http://dicom.nema.org/resources/ontology/DCM/122664] late contrast enhancement EFO:0600035 MIO:00366 The volume of the heart's left atrium (left atrial volume) is an important biomarker for cardiovascular physiology and clinical cardiology. It is usually calculated as left atrial volume index in terms of body surface area. [url:https://en.wikipedia.org/wiki/Left_atrial_volume] left atrial volume LAVI LAVImax heart left atrium capacity indexed left atrial maximum volume left atrial maximum volume index left atrial volume index VT:0007075 MIO:00367 The distance between the surfaces of the wall of the left lower chamber of the heart. [ https://www.worldcat.org/search?q=bn%3A0-683-40008-8 ] [url:http://purl.obolibrary.org/obo/VT_0007075] left ventricle wall thickness LVWT heart left ventricle wall thickness left ventricular segmental wall thickness NCIT:C99524 UMLS:C2700378 MIO:00368 The fraction of the left ventricular end diastolic volume ejected with each beat. The left ventricular ejection fraction is equal to the left ventricular stroke volume divided by the left ventricular end diastolic volume. [url:http://purl.obolibrary.org/obo/NCIT_C99524] left ventricular ejection fraction LVEF ejection fraction CMO:0000982 MIO:00369 The diameter across the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter. [url:http://purl.obolibrary.org/obo/CMO_0000982] left ventricular end-diastolic diameter LVEDD PMID:19356570 MIO:00370 Microvascular resistance index was calculated as the ratio of mean Pd to average peak flow velocity during maximal hyperemia. [url:https://pubmed.ncbi.nlm.nih.gov/19356570/] microvascular resistance index IMR MVRI index of microcirculatory resistance NCIT:C94939 MIO:00371 Perfusion of blood through the myocardium. [url:http://purl.obolibrary.org/obo/NCIT_C94939] myocardial blood flow MBF myocardial flow myocardial perfusion myocardial tissue perfusion PMID:10520780 MIO:00372 Myocardial contractile reserve was defined as improvement in wall thickening of ≥1 grade. A dyskinetic segment (score 5) becoming akinetic (score 4) during stress was not considered viable. Contractile reserve was considered to be present in a patient when improvement in wall thickening concerned at least two contiguous infarct zone segments. [url:https://pubmed.ncbi.nlm.nih.gov/10520780/] myocardial contractile reserve contractile reserve PMID:15979425 MIO:00373 Myocardial contrast opacification was scored on a 3-point scale (2 = normal [i.e., homogenous], 1 = patchy, or 0 = absent) using the same 16-segment model. [url:https://pubmed.ncbi.nlm.nih.gov/15979425/] myocardial contrast opacification contrast intensity contrast opacification myocardial contrast intensity perfusion score HP:4000004 MIO:00374 LGE can be detected in post-infarct scars, inflammation, as well as non-ischemic CMP, cardiac neoplasm and storage diseases such as amyloidosis.[url:http://purl.obolibrary.org/obo/HP_4000004] Areas of high signal intensity in magnetic resonance imaging of the heart appearing 10 to 15 minutes after injection of the intercellular contrast agent gadolinium. [url:http://purl.obolibrary.org/obo/HP_4000004] myocardial late gadolinium enhancement LGE delayed enhancement delayed myocardial gadolinium enhancement late enhancement late gadolinium enhancement late gadolinium-enhanced myocardial contrast-delayed enhancement pattern myocardial delayed enhancement NCIT:C139043 MIO:00375 A calculated result that uses the following base formula to quantify both systolic and diastolic ventricular function: MPI = (IVCT + IVRT)/VET, where IVCT is isovolumetric contraction time, IVRT is isovolumetric relaxation time, and VET is ventricular ejection time. [url:http://purl.obolibrary.org/obo/NCIT_C139043] myocardial performance index IMP LVMPI MPI left ventricular myocardial performance index myocardial performance index XCO:0000641 MIO:00376 Any experimental condition in which the flow of blood to the heart is restored after a period of blood vessel occlusion occurred naturally or experimentally. [url:http://purl.obolibrary.org/obo/XCO_0000641] myocardial reperfusion reperfusion reperfusion phenomenon spontaneous reperfusion successful thrombolysis PMID:12804927 MIO:00377 Salvage index was then calculated as the proportion of the initial perfusion defect that was salvaged by reperfusion. [url:https://pubmed.ncbi.nlm.nih.gov/12804927/] myocardial salvage index MSI myocardial salvage salvage index PMID:32833510 MIO:00378 Pathophysiologically, myocardial viability refers to those cardiomyocytes that are alive, defined by a presence of cellular, metabolic, and microscopic contractile function. On the other hand, in a clinical setting, viability is defined by the presence of dysfunctional myocardium at rest with a potential for functional recovery on restoration of normal blood supply. [url:https://pubmed.ncbi.nlm.nih.gov/32833510/] myocardial viability myocardial cellular viability viability viable myocardium HP:4000006 MIO:00379 Increased duration of myocardial T1 time without gadolinium contrast. T1 mapping consists of quantifying the T1 relaxation time of a tissue by using analytical expressions of image-based signal intensities. A fundamental principle of MR imaging is that the signal intensity of pixels is based on the relaxation of hydrogen nuclei protons in a static magnetic field. The T1 relaxation times between two tissues vary substantially. Edema, fat infiltration, and fibrosis also cause differences in T1 relaxivity.[url:http://purl.obolibrary.org/obo/HP_4000006] native T1 T1 mapping T1 value T1 values myocardial native T1 native T1 mapping PMID:19840559 MIO:00380 The perfusion score index (PSI) was obtained by summing the contrast scores of all segments and dividing by the total number of segments. The PSI represented the extent and intensity of residual infarction and thus residual myocardial viability on MCE. [PMID:19840559] [url:https://pubmed.ncbi.nlm.nih.gov/19840559/] perfusion score index CPI MPSI PSI contrast perfusion index contrast score index myocardial contrast perfusion myocardial perfusion score index DICOM:122354 MIO:00381 Fractional area within the External Elastic Membrane (EEM) occupied by atheroma. Plaque Burden = (EEM area - vessel lumen cross-sectional area) / EEM area. [url:http://dicom.nema.org/resources/ontology/DCM/122354] plaque burden PMID:33382775 MIO:00382 Post-systolic shortening (PSS) was defined as persistent shortening beyond aortic valve closure (PSS = peak negative strain in the cardiac cycle—peak negative strain in systole). Thus, PSS were negative values. PSS was average of segmental PSS from 18 segments. Mechanical dispersion was measured as standard deviation (SD) of time from onset Q in electrocardiography to peak negative longitudinal strain from 18 segments. [url:https://pubmed.ncbi.nlm.nih.gov/33382775/] post-systolic shortening PSS postsystolic shortening NCIT:C122087 MIO:00383 The rate at which a pressure wave moves distally through an artery, which is a direct measure of arterial stiffness. Clinically, this value is calculated by placing two pressure catheters a known distance apart (pulse wave distance), measuring the pressure wave's travel time between sensors (pulse transit time), and then dividing the distance by the transit time. [url:http://purl.obolibrary.org/obo/NCIT_C122087] pulse wave velocity PWV PMID:24993985 MIO:00384 The Rentrop score is utilized to provide an index of collateral vessel development, and in particular, our results indicate a Rentrop score of 2 or 3, reflecting good collateral formation from the non-infarct related artery. [url:https://pubmed.ncbi.nlm.nih.gov/24993985/] Rentrop score Rentrop grade Rentrop’s classification NCIT:C135380 SNOMED:250939002 MIO:00385 The percent or fraction of the right ventricular end diastolic volume ejected in systole, which is calculated as the right ventricular stroke volume divided by the right ventricular end diastolic volume. [url:http://purl.obolibrary.org/obo/NCIT_C135380] right ventricular ejection fraction RVEF NCIT:C129953 MIO:00386 The maximum pressure exerted into the systemic arterial circulation during the contraction of the right ventricle of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C129953] right ventricular systolic pressure RVSP PMID:15347134 MIO:00387 SWT (%) = [(end-systolic wall thickness - end-diastolic wall thickness)/end-diastolic wall thickness]*100 [PMID:15347134] [url:https://pubmed.ncbi.nlm.nih.gov/15347134/] systolic wall thickening index SWT SWTI systolic wall thickening DICOM:122376 MIO:00388 Total amount of plaque between the EEM and the Lumen, over the entire region that is measured. Total Plaque Volume = EEM Volume - Lumen Volume. [url:http://dicom.nema.org/resources/ontology/DCM/122376] total plaque volume plaque volume SNOMED:85844000 MIO:00389 transmural extent of infarction TEI full thickness infarct infarct transmurality relative infarct transmurality through-and-through infarct transmural extent of myocardial scar transmural infarct transmural infarction transmural involvement transmurality index NBO:0001845 MIO:00390 Behavior related to the intake of substances. [url:http://purl.obolibrary.org/obo/NBO_0001845] consumption behavior MIO:00391 lifestyle modification life style modification lifestyle change lifestyle changes therapeutic lifestyle change therapeutic lifestyle changes NCIT:C17708 MIO:00392 Any form of exercise or movement. Physical activity may include planned activity such as walking, running, basketball, or other sports. Physical activity may also include other daily activities such as household chores, yard work, walking the dog, etc. [url:http://purl.obolibrary.org/obo/NCIT_C17708] physical activity NBO:0000024 MIO:00393 Observable characteristic of behavior related to the readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. [url:http://purl.obolibrary.org/obo/NBO_0000024] sleeping behavior SNOMED:284499009 MIO:00394 Maladaptive behavior is a type of behavior that is often used to reduce one's anxiety, but the result is dysfunctional and non-productive. [url:https://en.wikipedia.org/wiki/Adaptive_behavior] maladaptive behavior maladaptive behaviour NBO:0000034 MIO:00395 Behaviour related to the activity which primary purpose is the sexual reproduction. [url:http://purl.obolibrary.org/obo/NBO_0000034] sexual activity sexual actions NCIT:C25150 PMID:29083808 MIO:00396 How long something has existed; elapsed time since birth. [url:http://purl.obolibrary.org/obo/NCIT_C25150] age aged chronological age NCIT:C54706 PMID:29083808 UMLS:C0005823 MIO:00397 Blood pressure is usually high, but hypotension if the patient is in shock.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] The pressure of the circulating blood against the walls of the blood vessels. [url:http://purl.obolibrary.org/obo/NCIT_C54706] blood pressure BP NCIT:C119246 MIO:00398 The total volume of blood pumped by the heart over a set period of time, conventionally one minute; it is calculated as heart rate times stroke volume (CO= HR x SV), and is additionally dependent on preload and afterload for functional output. [url:http://purl.obolibrary.org/obo/NCIT_C119246] cardiac output CARDOUT cardiac power output MIO:00399 The feature of ECG. ECG feature electrocardiographic feature NCIT:C17357 NCIT:C28421 PMID:29083808 UMLS:C0079399 MIO:00400 The assemblage of physical properties or qualities by which male is distinguished from female; the physical difference between male and female; the distinguishing peculiarity of male or female. [url:http://purl.obolibrary.org/obo/NCIT_C28421] gender sex NCIT:C49677 MIO:00401 The number of heartbeats per unit of time, usually expressed as beats per minute. [url:http://purl.obolibrary.org/obo/NCIT_C49677] heart rate HR MIO:00402 The shock index (heart rate divided by systolic blood pressure) is a stronger predictor of the impact of blood loss than heart rate and blood pressure alone. [url:https://en.wikipedia.org/wiki/Shock_(circulatory)] shock index shock index (SI) NCIT:C111361 MIO:00403 The maximum volume of air that can be exhaled after forced maximum inhalation. [url:http://purl.obolibrary.org/obo/NCIT_C111361] forced vital capacity forced vital capacity fvc NCIT:C61455 MIO:00404 A finding which can be heard on auscultation of the heart in the setting of congestive heart failure. The sound of the S3 gallop, which immediately follows the second heart sound (S2) is thought to be produced by the sound of blood flowing into a noncompliant ventricle. [url:http://purl.obolibrary.org/obo/NCIT_C61455] S3 gallop s3 s3 gallop s3 heart sound third heart sound ventricular gallop NCIT:C64193 MIO:00405 The lateral prominence of the pelvis from the waist to the thigh. [url:http://purl.obolibrary.org/obo/NCIT_C64193] hip hip NCIT:C71258 MIO:00406 The mass of the body minus the fat. [url:http://purl.obolibrary.org/obo/NCIT_C71258] lean body mass lbm lean body mass PMID:28721147 MIO:00407 Conicity index (Cindex) = waist circumference (WC)/(0.109 * (weight/height) [PMID:28721147] conicity index Cindex PMID:29382891 MIO:00408 The coronary wedge pressure was defined as the mean distal coronary pressure measured from the tip of the dilation catheter while the balloon was inflated in the stenosis with a pressure of 2 atmospheres.[PMID:29382891] coronary wedge pressure CWP MIO:00409 FEV1 is the volume of air that can forcibly be blown out in first 1 second, after full inspiration. [url:https://en.wikipedia.org/wiki/Spirometry#Forced_expiratory_volume_in_1_second_.28FEV1.29] forced expiratory volume in one second FEV1 MIO:00410 A functional capacity evaluation (FCE) is a set of tests, practices and observations that are combined to determine the ability of the evaluated person to function in a variety of circumstances, most often employment, in an objective manner. Physicians change diagnoses based on FCEs. hey are also required by insurers in when an insured person applies for disability payments or a disability pension in the case of permanent disability.[url:https://en.wikipedia.org/wiki/Functional_capacity_evaluation] functional capacity FCE PMID:16716016 MIO:00411 Inflection time was defined as the time interval from initiation of a systolic pressure waveform to the inflection point.[PMID:16716016] inflection time MIO:00412 left ventricle contractility LV contractility PMID:3078547 MIO:00413 Left ventricular stroke work index (LVSWI in grams per square meter) was calculated from stroke index (SI), mean systolic arterial pressure (MAP), and pulmonary capillary pressure (PCP) [0.0136 x SI x (MAP - PCP)]. [PMID:3078547] left ventricular stroke work index LVSWI PMID:10809494 MIO:00414 QRS complex onset was defined as the mid-point of a 5-msec interval where the average first deviates 3 SD over the noise level when approaching the QRS complex.[PMID:10809494] MCG QRS complex PMID:25585377 MIO:00415 The systolic pressures of the pulse waves following RRi and RRi+1 were labeled Pi and Pi+1. PESPAfib was calculated as (Pi+1-Pi)/(RRi+1-RRi).[PMID:25585377] PESPAfib VT:0010826 MIO:00416 The distance from point to point along the longest axis of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor.[url:http://purl.obolibrary.org/obo/VT_0010826] tongue length PMID:32218225 MIO:00417 UTCC was calculated as the upstroke time divided by cardiac cycle.[PMID:32218225] upstroke time per cardiac cycle UTCC EFO:0003912 NCIT:C87304 OMIT:0026150 PMID:33086427 MIO:00418 The ratio of ankle systolic pressure to brachial systolic pressure, used to assess arterial insufficiency in the lower extremities. [url:http://purl.obolibrary.org/obo/NCIT_C87304] ankle brachial index ABI Toe-Brachial Indices Toe-Brachial index ankle brachial pressure index ankle-arm index ankle-arm pressure index ankle-brachial index ankle-brachial pressure index PMID:18426445 MIO:00419 The evaluation of baroreflex sensitivity (BRS) is an established tool for the assessment of autonomic control of the cardiovascular system. Besides the well‐acknowledged physiological role in the maintenance of circulatory homeostasis, evidence has been accumulated that changes in the characteristics of baroreflex function reflect alterations in autonomic control of the cardiovascular system. [url:https://pubmed.ncbi.nlm.nih.gov/18426445/] baroreflex sensitivity BRS baroreflex sensitivity (BRS) MIO:00420 The body adiposity index (BAI) is a method of estimating the amount of body fat in humans. The BAI is calculated without using body weight, unlike the body mass index (BMI). Instead, it uses the size of the hips compared to the person's height. Based on population studies, the BAI is approximately equal to the percentage of body fat for adult men and women of differing ethnicities. [url:https://en.wikipedia.org/wiki/Body_adiposity_index] body adiposity index NCIT:C164634 MIO:00421 The vertical measurement or distance from the base to the top of a subject or participant. [url:http://purl.obolibrary.org/obo/NCIT_C164634] body height height subject height NCIT:C16358 UMLS:C1305855 MIO:00422 A measure that relates body weight to height. BMI is sometimes used to measure total body fat and whether a person is a healthy weight. Excess body fat is linked to an increased risk of some diseases including heart disease and some cancers. A measurement that is used to indicate the body fat an individual is carrying based on the ratio of weight to height as measured in kilograms per square meters. A general indicator of the body fat an individual is carrying based upon the ratio of weight to height. [url:http://purl.obolibrary.org/obo/NCIT_C16358] body mass index BMI quetelet Index NCIT:C25157 MIO:00423 A measurement that indicates overall patient size incorporating one of several different accepted equations, as measured in square meters. A measure of the 2-dimensional extent of the body surface (i.e., the skin). Body surface area (BSA) can be calculated by mathematical formula or from a chart that relates height to weight. BSA is often an important factor in dosing. [url:http://purl.obolibrary.org/obo/NCIT_C25157] body surface area BSA NCIT:C88164 MIO:00424 The ability of the heart and lungs to deliver blood and oxygen to the tissues during aerobic activity. It is a general measure of the relative conditioning of the heart and respiratory system. [url:http://purl.obolibrary.org/obo/NCIT_C88164] cardiorespiratory fitness SNOMED:165079009 MIO:00425 exercise tolerance exercise capacity exercise test exercise tolerance test NCIT:C129955 UMLS:C0034094 MIO:00426 The pressure measured by wedging a pulmonary catheter with an inflated balloon into a small pulmonary arterial branch. [url:http://purl.obolibrary.org/obo/NCIT_C129955] pulmonary artery wedge pressure PAOP PAWP PCWP PWP cross-sectional pressure pulmonary arterial wedge pressure pulmonary artery occlusion pressure pulmonary capillary wedge pressure pulmonary wedge pressure NCIT:C49676 MIO:00427 The rate of the pulse as observed in an artery, expressed as beats per minute. It can be measured at several anatomic sites, including the wrist, neck, temple, groin, behind the knees, or on top of the foot. [url:http://purl.obolibrary.org/obo/NCIT_C49676] pulse rate NCIT:C49678 MIO:00428 The rate of breathing (inhalation and exhalation) measured within in a unit time, usually expressed as breaths per minute. [url:http://purl.obolibrary.org/obo/NCIT_C49678] respiratory rate NCIT:C100948 UMLS:C0455829 MIO:00429 A circumferential measurement of the waist, which may be classified as the area immediately below the lowest rib, at the narrowest part of the torso, midpoint between the lowest rib and the iliac crest, or immediately above the iliac crest. [url:http://purl.obolibrary.org/obo/NCIT_C100948] waist circumference WSTCIR CMO:0000020 EFO:0005191 OMIT:0028788 MIO:00430 A quantification of the waist-height WHtR - a measurement of body fat distribution. [url:http://www.ebi.ac.uk/efo/EFO_0005191] waist-height ratio WHtR Waist-to-height ratio waist height ratio NCIT:C17651 UMLS:C0205682 MIO:00431 The ratio of the abdominal circumference at the navel to maximum hip and buttocks circumference; looks at the proportion of fat stored on the body around the waist and hip. Carrying extra weight around the waist is a greater health risk than carrying extra weight around the hips or thighs. [url:http://purl.obolibrary.org/obo/NCIT_C17651] waist-hip ratio WAISTHIP waist to hip ratio SIO:000276 MIO:00432 An emotion is a process (experience) that arises internally or from an involuntary physiological response to a stimulus [url:http://semanticscience.org/resource/SIO_000276] emotion NCIT:C179143 MIO:00433 The state of a person with regard to earning wages or salary. [url:http://purl.obolibrary.org/obo/NCIT_C179143] employment status NCIT:C157356 MIO:00434 A type of insurance designed to cover some of or all the cost of treating an insured person's illnesses or injuries. In some cases, it pays for preventive care, such as annual physicals and diagnostic tests. [url:http://purl.obolibrary.org/obo/NCIT_C157356] health insurance health insurance insurance MIO:00435 Job control is a person's ability to influence what happens in their work environment, in particular to influence matters that are relevant to their personal goals. Job control may include control over work tasks, control over the work pace and physical movement, control over the social and technical environment, and freedom from supervision. [url:https://en.wikipedia.org/wiki/Job_control_(workplace)] job control workplace autonomy NCIT:C94852 MIO:00436 A description of a personal residence and the relationship between the occupants that reside there. [url:http://purl.obolibrary.org/obo/NCIT_C94852] living arrangement cohabitation status living arrangements NCIT:C25188 MIO:00437 A demographic parameter indicating a person's current conjugal status. [url:http://purl.obolibrary.org/obo/NCIT_C25188] marital status MARISTAT Marital Status MaritalStatus MaritalStatusUB92 marital or partnership status NCIT:C38002 OMIT:0011542 MIO:00438 The complex of all the attributes--behavioral, temperamental, emotional and mental--that characterize a unique individual. [url:http://purl.obolibrary.org/obo/NCIT_C38002] personality NCIT:C17049 MIO:00439 An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution. [url:http://purl.obolibrary.org/obo/NCIT_C17049] race ethnic group ethnic groups racial group racialized group NCIT:C93218 MIO:00440 An individuals' perception of the amount of positive support (e.g., love, care, concern) and negative support (e.g., demand, critique) that they experience. [url:http://purl.obolibrary.org/obo/NCIT_C93218] social support OPMI:0000121 MIO:00441 The personal information that indicates an individual's or his/her family's economic and social position in relation to others, based on income, education, and occupation. [url:http://purl.obolibrary.org/obo/OPMI_0000121] socioeconomic status SES socioeconomic class socioeconomic condition NCIT:C176259 MIO:00442 The degree to which an individual has the capacity to obtain, communicate, process, and understand basic health information and services to make health decisions. (After The Patient Protection and Affordable Care Act of 2010, Title V; After What is Health Literacy? Oct 23, 2019) [url:http://purl.obolibrary.org/obo/NCIT_C176259] health literacy health literacy GSSO:003000 MIO:00443 A form of child abuse in which an adult or older adolescent abuses a child for sexual stimulation. Sexual abuse refers to the participation of a child in a sexual act aimed toward the physical gratification or the financial profit of the person committing the act. Forms of child sexual abuse include asking or pressuring a child to engage in sexual activities (regardless of the outcome), indecent exposure of the genitals to a child, displaying pornography to a child, actual sexual contact with a child, physical contact with the child's genitals, viewing of the child's genitalia without physical contact, or using a child to produce child pornography. [url:http://purl.obolibrary.org/obo/GSSO_003000] child sexual abuse sexual child abuse MIO:00444 social dominance orientation MIO:00445 exposure to cumulative social risk MIO:00446 positive effects of illness MIO:00447 quality of psychological domain MIO:00448 quality of social relationships domain MIO:00449 The job in restaurant. restaurant worker MIO:00450 sense of time urgency MIO:00451 illness perception MIO:00452 John Henryism (JH) is a strategy for coping with prolonged exposure to stresses such as social discrimination by expending high levels of effort which results in accumulating physiological costs.[url:https://en.wikipedia.org/wiki/John_Henryism] John Henryism MIO:00453 low emotional sensitivity MIO:00454 low predictability at work MIO:00455 The job is relatively poorly paid. low reward at work MIO:00456 The "sense of coherence" is a theoretical formulation that provides a central explanation for the role of stress in human functioning. "Beyond the specific stress factors that one might encounter in life, and beyond your perception and response to those events, what determines whether stress will cause you harm is whether or not the stress violates your sense of coherence." [url:https://en.wikipedia.org/wiki/Salutogenesis#Sense_of_coherence] sense of coherence MIO:00457 Perceived control (PC) can be defined as the belief that one sees they have control over their inside state, behaviors and the place or people or things or feelings or activities surrounding a person. There are two important dimensions: (1) whether the object of control is in the past or the future and (2) whether the object of control is over outcome, behavior, or process. [url:https://en.wikipedia.org/wiki/Perceived_control] perceived control PC MIO:00458 Working time is the period of time that a person spends at paid labor. Unpaid labor such as personal housework or caring for children or pets is not considered part of the working week. [url:https://en.wikipedia.org/wiki/Working_time] working time working hours NCIT:C159384 SNOMED:133921002 MIO:00459 A question about an individual meeting their own emotional support needs. [url:http://purl.obolibrary.org/obo/NCIT_C159384] emotional support psychological support SNOMED:102912007 MIO:00460 fear of death fear of dying MIO:00461 Job demands: physical, psychological, social, or organizational aspects of the job, that require sustained physical and/or psychological effort or skills. Therefore, they are associated with certain physiological and/or psychological costs. Examples are work pressure and emotional demands. [url:https://en.wikipedia.org/wiki/Job_demands-resources_model] job demand job demands work demand MIO:00462 Psychosocial work environment pertains to interpersonal and social interactions that influence behavior and development in the workplace. Research has been conducted to determine the effects of the psychosocial work environment on stress levels and overall health. One study in particular found that low levels of support and control at work leads to increased rates of sickness absence (North, Syme, Feeney, Shipley, & Marmot, 1996). In other words, a positive and supportive psychosocial work environment is beneficial to employees in an occupational organization. [url:https://link.springer.com/referenceworkentry/10.1007%2F978-1-4419-1005-9_920howtocite] psychosocial work environment NCIT:C21100 MIO:00463 A condition in which an individual feels or is made to feel as though he or she has no place within society. This is often the case with persons who have inadequate support systems or who suffer from stigmatized disease, such as AIDS and mental illness. [url:http://purl.obolibrary.org/obo/NCIT_C21100] social isolation NCIT:C67147 MIO:00464 An adult who has smoked 100 cigarettes in his or her lifetime and who currently smokes cigarettes. Includes daily smokers and non-daily smokers (also known as occasional smokers). [url:http://purl.obolibrary.org/obo/NCIT_C67147] current smoker actively smoking current smokers current smoking NCIT:C122444 MIO:00465 A reduction in the normal physical activity for an individual. [url:http://purl.obolibrary.org/obo/NCIT_C122444] decreased physical activity low PA low physical activity DOID:9351 MESH:D003920 NCIT:C2985 PMID:22279115 PMID:29083808 PMID:32829713 PMID:9034940 SNOMED:267467004 UMLS:C0011849 MIO:00466 A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization. [url:http://purl.obolibrary.org/obo/NCIT_C2985] diabetes mellitus DM diabetes diabetics MIO:00467 family history of cardiovascular disease family medical history of cardiovascular disease paternal history of cardiovascular disease DOID:10763 EFO:0000537 MESH:D006973 NCIT:C3117 PMID:22537796 PMID:29083808 PMID:32829713 PMID:9034940 SNOMED:38341003 UMLS:C0020538 MIO:00468 Blood pressure that is abnormally high. [url:http://purl.obolibrary.org/obo/NCIT_C3117] hypertension HTN high blood pressure hyperpiesia hypertension hypertensive disease vascular hypertensive disorder HP:0004324 MIO:00469 Abnormally increased body weight. [url:http://purl.obolibrary.org/obo/HP_0004324] increased body weight body mass index > or = 25 kg/m2 obesity or overweight overweight or obesity OPMI:0000436 PATO:0000308 SNOMED:49808004 MIO:00470 An age which is relatively high. [ PATOC:GVG ] [url:http://purl.obolibrary.org/obo/PATO_0000308] old age advanced age elderly old old age old-age older older age SNOMED:266961004 MIO:00471 Shift work is an employment practice designed to make use of, or provide service across, all 24 hours of the clock each day of the week (often abbreviated as 24/7). The practice typically sees the day divided into shifts, set periods of time during which different groups of workers perform their duties. The term "shift work" includes both long-term night shifts and work schedules in which employees change or rotate shifts. [url:https://en.wikipedia.org/wiki/Shift_work] shift worker shift work shift workers NCIT:C46109 MIO:00472 An individual who reports belonging to the cultural gender role distinction of male. [url:http://purl.obolibrary.org/obo/NCIT_C46109] male gender male male sex males man men men gender NCIT:C71065 SNOMED:54329005 MIO:00473 An electrocardiographic finding of pathologic Q waves with accompanying ST elevation in leads V3 and V4, which is suggestive of acute myocardial infarction of the anterior wall of the left ventricle. [url:http://purl.obolibrary.org/obo/NCIT_C71065] acute anterior myocardial infarction acute anterior MI acute anterior wall myocardial infarction acute myocardial infarction of anterior wall anterior AMI DOID:10651 UMLS:C0155627 MIO:00474 acute anterolateral myocardial infarction NCIT:C102592 SNOMED:62695002 MIO:00475 An electrocardiographic finding of pathologic Q waves with accompanying ST elevation in leads V1 through V4, which is suggestive of acute myocardial infarction of the anteroseptal wall of the left ventricle. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C102592] acute anteroseptal myocardial infarction acute anteroseptal MI acute anteroseptal wall myocardial infarction NCIT:C71066 SNOMED:73795002 MIO:00476 An electrocardiographic finding of pathologic Q waves with accompanying ST elevation in leads III, aVF and often II, which is suggestive of acute myocardial infarction of the inferior wall of the left ventricle. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C71066] acute inferior myocardial infarction acute inferior MI acute inferior wall myocardial infarction acute myocardial infarction of inferior wall DOID:10649 SNOMED:65547006 UMLS:C0155636 MIO:00477 acute inferolateral myocardial infarction acute myocardial infarction of inferolateral wall NCIT:C71067 SNOMED:58612006 MIO:00478 An electrocardiographic finding of pathologic Q waves with accompanying ST elevation in leads V5, V6, I and aVL, which is suggestive of acute myocardial infarction of the lateral wall of the left ventricle. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C71067] acute lateral myocardial infarction acute myocardial infarction of lateral wall MIO:00479 acute myocardial infarction with non-obstructive coronary arteries acute MI with non-obstructive coronary arteries acute MINOCA SNOMED:401314000 MIO:00480 acute non-ST elevation myocardial infarction NSTE-ACS acute NSTEMI acute non-Q wave myocardial infarction acute non-ST segment elevation myocardial infarction acute subendocardial MI acute subendocardial myocardial infarction non-Q wave AMI DOID:9407 NCIT:C71068 SNOMED:233838001 UMLS:C0155652 MIO:00481 An electrocardiographic finding in leads V1 or V2 of an initial R wave duration greater than or equal to 40 ms, R wave greater than S wave, upright T wave, with accompanying ST elevation, which is suggestive of acute myocardial infarction of the posterior wall of the left ventricle. Evidence of inferior or lateral myocardial infarction is usually also present. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C71068] acute posterior myocardial infarction strictly posterior acute myocardial infarction SNOMED:70998009 MIO:00482 acute posterobasal myocardial infarction acute myocardial infarction of posterobasal wall DOID:10648 UMLS:C0155640 MIO:00483 acute posteroinferior myocardial infarction acute inferoposterior infarction acute inferoposterior myocardial infarction SNOMED:15990001 MIO:00484 acute posterolateral myocardial infarction acute myocardial infarction of posterolateral wall NCIT:C102594 UMLS:C3640832 MIO:00485 An electrocardiographic finding in leads V1 or V2 of an initial R wave duration greater than or equal to 40 ms, R wave greater than S wave, upright T wave, with accompanying ST elevation, which is suggestive of acute myocardial infarction of the ventricular wall of the left ventricle. Evidence of inferior or lateral myocardial infarction is usually also present. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C102594] acute right ventricular myocardial infarction acute RVMI acute right ventricular MI acute right ventricular wall myocardial infarction ICD11:BA41.0 MIO:00486 STEMI is an acute myocardial infarction with developing ST elevation in two contiguous leads. The criteria of ST elevation is follows; New ST elevation at the J point in two contiguous leads with the cut-points apply: 0.2mV in men>40 years; >0.25mV in men<40 years, or >0.15 mV in women. [url:http://id.who.int/icd/entity/391388807] acute ST elevation myocardial infarction acute ST elevation MI acute ST segment elevation myocardial infarction acute STEMI MIO:00487 acute type 1 myocardial infarction acute type 1 MI acute type I MI acute type I myocardial infarction type 1 AMI type 1 acute myocardial infarction MIO:00488 acute type 2 myocardial infarction acute type II MI SNOMED:52035003 MIO:00489 acute anteroapical myocardial infarction acute anteroapical infarction MIO:00490 acute myocardial infarction with cardiogenic shock AMI with cardiogenic shock AMICS CS complicating acute myocardial infarction acute myocardial infarction complicated by cardiogenic shock SNOMED:30277009 MIO:00491 acute myocardial infarction with rupture of ventricle NCIT:C102595 MIO:00492 An electrocardiographic finding of pathologic Q waves with accompanying ST elevation in leads V1, V2 and often V3, which is suggestive of acute myocardial infarction of the intraventricular septum. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C102595] acute septal myocardial infarction acute septal MI acute septal wall myocardial infarction MIO:00493 acute silent myocardial infarction acute SMI acute silent MI silent AMI silent acute MI silent acute myocardial infarction MIO:00494 acute type 3 myocardial infarction MIO:00495 acute type 4a myocardial infarction acute type 4a MI acute type IVa MI acute type IVa myocardial infarction MIO:00496 acute type 4b myocardial infarction acute type 4b MI acute type IVb MI acute type IVb myocardial infarction MIO:00497 acute type 5 myocardial infarction acute type V MI SNOMED:233835003 MIO:00498 acute widespread myocardial infarction MIO:00499 anterior ST elevation myocardial infarction anterior Q-wave MI anterior Q-wave myocardial infarction anterior ST segment elevation myocardial infarction anterior STEMI MIO:00500 old anterior myocardial infarction old anterior MI previous anterior MI previous anterior myocardial infarction prior anterior MI prior anterior myocardial infarction SNOMED:194857001 MIO:00501 subsequent myocardial infarction of anterior wall MIO:00502 inferior ST elevation myocardial infarction SNOMED:194858006 MIO:00503 subsequent myocardial infarction of inferior wall MIO:00504 old inferior myocardial infarction old inferior MI NCIT:C102643 MIO:00505 An electrocardiographic finding of pathologic Q waves in leads I and aVL, which is suggestive of myocardial infarction of the high lateral wall of the left ventricle. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C102643] high lateral myocardial infarction MIO:00506 type 1 non-ST elevation myocardial infarction type 1 NSTEMI type 1 non-ST segment elevation myocardial infarction MIO:00507 type 2 non-ST elevation myocardial infarction type 2 NSTEMI type 2 non-ST segment elevation myocardial infarction type II non-ST elevation myocardial infarction EFO:0008586 ICD11:BA42.1 SNOMED:703360004 MIO:00508 Extension or recurrent myocardial infarction. For morbidity coding, this category should be assigned for infarction of any myocardial site, occurring within 4 weeks (28 days) from onset of a previous infarction. This most commonly results from severe obstruction, but not total occlusion, of the culprit coronary artery. [url:http://id.who.int/icd/entity/2070501946] subsequent non-ST elevation myocardial infarction subsequent non-ST segment elevation myocardial infarction MIO:00509 old ST elevation myocardial infarction old Q wave MI old ST elevation MI old ST segment elevation myocardial infarction old STEMI previous Q-wave MI previous Q-wave myocardial infarction previous ST elevation myocardial infarction previous STEMI prior Q-wave MI prior Q-wave myocardial infarction prior ST elevation myocardial infarction prior STEMI MIO:00510 old silent myocardial infarction PMID:30571511 MIO:00511 Myocardial infarction associated with coronary angioplasty or stents. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] type 4 myocardial infarction PCI-related MI myocardial infarction type 4 type 4 MI type IV MI type IV myocardial infarction NCIT:C119226 PMID:30571511 MIO:00512 Myocardial Infarction associated with coronary artery bypass grafting. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] type 5 myocardial infarction CABG-related MI type 5 MI type V MI type V myocardial infarction EFO:0008585 ICD11:BA42.0 SNOMED:703211006 MIO:00513 Extension or recurrent myocardial infarction. This category should be assigned for infarction of any myocardial site, occurring within 4 weeks (28 days) from onset of a previous infarction. This most commonly results from total occlusion of the culprit coronary artery. [url:http://id.who.int/icd/entity/1401866267] subsequent ST elevation myocardial infarction subsequent ST segment elevation myocardial infarction MIO:00514 type 1 ST elevation myocardial infarction type 1 STEMI type I ST elevation myocardial infarction type I STEMI SNOMED:170969009 MIO:00515 bad prognosis poor prognosis prognosis bad prognosis poor SNOMED:170968001 MIO:00516 good prognosis favorable prognosis prognosis favorable prognosis favourable prognosis good SNOMED:251054004 MIO:00517 myocardial perfusion defect hypoperfusion impaired myocardial flow impaired myocardial perfusion impaired perfusion inadequate myocardial tissue perfusion insufficient myocardial reperfusion perfusion defect poor myocardial perfusion reduced myocardial perfusion SNOMED:238163001 MIO:00518 increased oxygen demand Increased myocardial oxygen demand PMID:30153967 MIO:00519 reduce oxygen supply NCIT:C61009 MIO:00520 The specific reaction pattern of erythrocytes of an individual to the antisera of one blood group; e.g., the ABO blood group consists of four major blood types: O, A, B, and AB. This classification depends on the presence or absence of two major antigens: A or B. Type O occurs when neither is present and type AB when both are present. The blood type is the genetic phenotype of the individual for one blood group system and may be determined using different antisera available for testing. [url:http://purl.obolibrary.org/obo/NCIT_C61009] blood type blood group NCIT:C17047 MIO:00521 The subjective measurement of an individual's sense of well-being and ability to enjoy life. The concept holds varying meanings for different people and may evolve over time. For some individuals it implies autonomy, empowerment, capability, and choice; for others, security, social integration, or freedom from stress or illness. [url:http://purl.obolibrary.org/obo/NCIT_C17047] quality of life QOL quality-of-life NCIT:C176764 MIO:00522 The location where someone was born, usually referring to a town, city, or country. [url:http://purl.obolibrary.org/obo/NCIT_C176764] birthplace place of Birth MIO:00523 Drugs for primary prevention of myocardial infarction. medication adjunctive drug therapies adjunctive drug therapy drug medications medicine PMID:20351550 MIO:00524 Guidelines recommend that patients should receive treatment with acetyl salicylic acid (ASA), clopidogrel, b-blocker, angiotensin-converting enzyme (ACE) inhibitor or sartan and statin unless a contraindication exists. [url:https://pubmed.ncbi.nlm.nih.gov/20351550/] guideline-recommended secondary prevention drug therapy secondary prevention drug therapy NCIT:C51999 MIO:00525 An endovascular procedure used to widen diseased arteries resulting in increasing blood flow through the area. [url:http://purl.obolibrary.org/obo/NCIT_C51999] angioplasty NCIT:C38044 UMLS:C0018795 MIO:00526 A procedure in which a thin plastic tube (catheter) is inserted into an artery or vein in the arm or leg and then advanced into the chambers of the heart or into the coronary arteries. Catheterization can measure blood pressure within the heart and how much oxygen is in the blood. It's also used to get information about the pumping ability of the heart muscle. Catheters are also used to inject dye into the coronary arteries. Catheters with a balloon on the tip are used in the procedure called percutaneous transluminal coronary angioplasty. [url:http://purl.obolibrary.org/obo/NCIT_C38044] cardiac catheterization coronary catheterization heart cath NCIT:C100080 SNOMED:103716009 UMLS:C3272316 MIO:00527 A procedure performed during a percutaneous coronary intervention in which a device is deployed into the lumen of a coronary artery to expand and support the vessel wall such that the vessel remains patent and blood flow is uninhibited. [url:http://purl.obolibrary.org/obo/NCIT_C100080] cardiac stent placement coronary stent placement coronary stenting placement of a stent placement of stent stent stent implantation stent placement stenting NCIT:C157806 MIO:00528 A surgical procedure on the heart. [url:http://purl.obolibrary.org/obo/NCIT_C157806] cardiac surgery cardiac procedure cardiac procedures heart procedures heart surgery NCIT:C51998 SNOMED:232717009 UMLS:C0010055 MIO:00529 coronary artery bypass grafting CABG CBG aortocoronary bypass bypass surgery cardiac bypass surgery coronary artery bypass coronary artery bypass graft coronary artery bypass graft operation coronary artery bypass graft operations coronary artery bypass graft surgery coronary artery bypass surgery coronary artery graft coronary bypass graft heart bypass NCIT:C99540 SNOMED:232957001 UMLS:C3274791 MIO:00530 Use of a device to replace the function of a cardiac ventricle. This includes use of cardiopulmonary bypass, left ventricular assist device (LVAD), intra-aortic balloon pump (IABP) and/or extracorporeal membrane oxygenation (ECMO). [url:http://purl.obolibrary.org/obo/NCIT_C99540] mechanical circulatory support MCS MCSS cardiac support procedure circulatory support mechanical circulatory support system NCIT:C99521 UMLS:C1532338 MIO:00531 The placement of an angioplasty guide wire, balloon, or other device (e.g. stent, atherectomy, brachytherapy, or thrombectomy catheter) into a native coronary artery or coronary artery bypass graft for the purpose of mechanical coronary revascularization. [url:http://purl.obolibrary.org/obo/NCIT_C99521] percutaneous coronary intervention PCI NCIT:C52003 UMLS:C0162578 MIO:00532 Surgery performed with the purpose of removing a thrombus. [url:http://purl.obolibrary.org/obo/NCIT_C52003] thrombectomy NCIT:C157742 MIO:00533 Surgery to repair any of the valves of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C157742] valvular surgery valve surgery SNOMED:30904006 MIO:00534 vascular surgery procedure blood vessel operations operation on vessels vascular operation vascular surgery NCIT:C157793 MIO:00535 The removal of plaque from a blood vessel. [url:http://purl.obolibrary.org/obo/NCIT_C157793] atherectomy coronary atherectomy NCIT:C100068 MIO:00536 Catheter ablation is an invasive procedure used to remove or terminate a faulty electrical pathway from sections of the hearts of those who are prone to developing cardiac arrhythmias such as atrial fibrillation, atrial flutter, SVT and Wolff-Parkinson-White syndrome. [url:http://purl.obolibrary.org/obo/NCIT_C100068] catheter ablation NCIT:C80435 MIO:00537 A surgical procedure in which a small, battery-powered device is placed in the chest wall to detect arrhythmias and correct them by delivering a jolt of electricity. [url:http://purl.obolibrary.org/obo/NCIT_C80435] implantable cardioverter-defibrillator placement ICD cardioverter-defibrillator therapy implantable cardioverter-defibrillator implantable cardioverter-defibrillator procedure implantable cardioverter-defibrillators SNOMED:232965003 MIO:00538 A ventricular assist device (VAD) is an electromechanical device for assisting cardiac circulation, which is used either to partially or to completely replace the function of a failing heart. The function of a VAD differs from that of an artificial cardiac pacemaker in that a VAD pumps blood, whereas a pacemaker delivers electrical impulses to the heart muscle. Some VADs are for short-term use, typically for patients recovering from myocardial infarction (heart attack) and for patients recovering from cardiac surgery; some are for long-term use (months to years to perpetuity), typically for patients suffering from advanced heart failure. [url:https://en.wikipedia.org/wiki/Ventricular_assist_device] implantation of ventricular assist device VAD VAD implantation ventricular assist device ventricular assist device implantation SNOMED:609236006 MIO:00539 percutaneous cardiopulmonary bypass support PCPS percutaneous cardiopulmonary bypass percutaneous cardiopulmonary support peripheral cardiopulmonary support NCIT:C78275 UMLS:C2697895 MIO:00540 An agent that exerts an effect on the synthesis or function of blood, blood components or body fluids. [url:http://purl.obolibrary.org/obo/NCIT_C78275] agent affecting blood or body fluid NCIT:C78274 UMLS:C0280076 MIO:00541 An agent that exerts a physiologic effect on any anatomic entity that is part of the cardiovascular system, including the heart and blood vessels. [url:http://purl.obolibrary.org/obo/NCIT_C78274] agent affecting cardiovascular system cardiovascular agent cardiovascular agents cardiovascular drug cardiovascular drugs NCIT:C78272 UMLS:C2697973 MIO:00542 An agent that exerts a physiologic effect on neurotransmission or on any anatomic entity that is part of the nervous system, including the central nervous system (CNS) and peripheral nervous system (PNS). [url:http://purl.obolibrary.org/obo/NCIT_C78272] agent affecting nervous system NCIT:C29703 UMLS:C1516000 MIO:00543 An agent that reduces plasma lipids, such as cholesterol or low density lipoproteins (LDL), acting systemically or locally (intestines) to decrease fat digestion, absorption, production, and accumulation in the plasma and reducing pathogenic atherosclerosis and thrombosis. [url:http://purl.obolibrary.org/obo/NCIT_C29703] antilipidemic agent lipid-lowering agent lipid-lowering agents lipid-lowering drug lipid-lowering drugs NCIT:C275 MIO:00544 A group of organic or inorganic substances capable of preventing the genotoxic and carcinogenic effects of free-radical compounds. Antioxidants bind to and neutralize ('scavenge') free radicals, thereby transforming them into non-toxic compounds and blocking their genotoxic and carcinogenic effects. This class of agents includes the vitamins C and E, the carotenoids, and selenium. Organic antioxidants are found in high concentrations in fruits, seeds and vegetables. [url:http://purl.obolibrary.org/obo/NCIT_C275] antioxidant NCIT:C168966 MIO:00545 An agent used to modify the strength of the contraction of the heart muscle. [url:http://purl.obolibrary.org/obo/NCIT_C168966] inotropic support inotrope inotropic agent inotropic agents inotropic drug inotropic drugs SNOMED:372742009 UMLS:C0016018 MIO:00546 Thrombolysis, also called fibrinolytic therapy, is the breakdown (lysis) of blood clots formed in blood vessels, using medication. It is used in ST elevation myocardial infarction, stroke, and in cases of severe venous thromboembolism (massive pulmonary embolism or extensive deep vein thrombosis).The main complication is bleeding (which can be dangerous), and in some situations thrombolysis may therefore be unsuitable. Thrombolysis can also play an important part in reperfusion therapy that deals specifically with blocked arteries. [url:https://en.wikipedia.org/wiki/Thrombolysis] thrombolytic agent antithrombotic agent antithrombotic drug antithrombotic drugs fibrinolysis fibrinolytic agent fibrinolytic agents fibrinolytic drug fibrinolytic drugs fibrinolytic therapy lytic therapy thrombolysis thrombolytic agents thrombolytic drug thrombolytic drugs thrombolytic therapy NCIT:C15292 SNOMED:103735009 MIO:00547 The patient- and family-centered active holistic care of patients with advanced, progressive disease. Essential components of palliative care are: pain and symptom control, communication regarding treatment and alternatives, prognosis, and available services, rehabilitation services, care that addresses treatment and palliative concerns, intellectual, emotional, social, and spiritual needs, terminal care, support in bereavement. The goal of palliative care is an achievement of the best quality of life for patients and their families. [url:http://purl.obolibrary.org/obo/NCIT_C15292] palliative care comfort care palliation palliative palliative therapy symptom management symptoms management NCIT:C101234 UMLS:C0700431 MIO:00548 A medically supervised program to improve the health and well-being of people who have heart problems. This may include exercise training, education on heart healthy living, and/or counseling to reduce stress. [url:http://purl.obolibrary.org/obo/NCIT_C101234] cardiac rehabilitation NCIT:C12728 MIO:00549 The paired upper chambers of the heart. The left atrium receives oxygenated blood from the pulmonary vein and pumps blood into the left ventricle. The right atrium receives venous deoxygenated blood from the entire body via the superior and inferior vena cavae and pumps blood into the right ventricle. [url:http://purl.obolibrary.org/obo/NCIT_C12728] cardiac atrium atria of heart atrium atrium of heart heart atria heart atrium NCIT:C12730 MIO:00550 One of the two lower chambers of the heart that receives blood from an atrium and pumps blood to the arteries. [url:http://purl.obolibrary.org/obo/NCIT_C12730] cardiac ventricle cardiac ventricles cardiac ventricular structure heart ventricle ventricle ventricles FMA:7274 MIO:00551 Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees. [url:http://purl.obolibrary.org/obo/FMA_7274] wall of heart NCIT:C13002 MIO:00552 A muscle cell in heart tissue (myocardium). [http://purl.obolibrary.org/obo/NCIT_C13002] cardiomyocyte cardiocyte cardiomyocytes heart muscle cell NCIT:C12679 MIO:00553 A tubular structure through which the blood circulates in the body. Blood vessels constitute a network composed of arteries, arterioles, capillaries, venules, and veins. [url:http://purl.obolibrary.org/obo/NCIT_C12679] blood vessel blood vessel human blood vessel vessel vessel, blood HP:0003116 MIO:00554 An abnormality detectable by sonography of the heart (echocardiography). [url:http://purl.obolibrary.org/obo/HP_0003116] abnormal echocardiogram abnormal echocardiography SNOMED:251017008 MIO:00555 coronary artery patency artery patency NCIT:C100072 SNOMED:371895000 MIO:00556 The lesion considered to be responsible for the acute coronary syndrome. [url:http://purl.obolibrary.org/obo/NCIT_C100072] coronary culprit lesion culprit lesion culprit lesion of coronary artery culprit lesions BTO:0003698 MIO:00557 coronary plaque coronary atherosclerotic plaque plaque MIO:00558 infarct-related artery IRA culprit artery culprit vessel infarct-related coronary artery NCIT:C165530 MIO:00559 An angiographic finding characterized by delayed progression of contrast medium into distal epicardial vessels in the absence of significant coronary artery disease. [url:http://purl.obolibrary.org/obo/NCIT_C165530] coronary slow flow phenomenon CSF CSFP coronary SF phenomenon coronary slow flow impaired coronary flow slow-flow NCIT:C99996 MIO:00560 Number of major epicardial vessels with greater than or equal to 70% reduction in diameter or greater than or equal to 50% reduction in cross-sectional area. (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C99996] number of diseased coronary artery vessels number of culprit vessels number of diseased coronary vessels number of diseased vessels NCIT:C50727 MIO:00561 reocclusion reocclusion HP:0003115 NCIT:C168100 MIO:00562 A history of having had an abnormal electrocardiogram (ECG). [url:http://purl.obolibrary.org/obo/NCIT_C168100] abnormal electrocardiogram ECG changes EKG abnormality abnormal ECG abnormal EKG electrocardiographic abnormalities PMID:3964796 MIO:00563 exercise-induced ST segment change abnormal ST segment response during exercise abnormal ST segment response to maximal treadmill testing abnormal ST segment response to treadmill exercise abnormal ST-segment response to exercise exercise ST deviation exercise induced ST segment deviation exercise-induced ST shift MIO:00564 exercise-induced T wave normalization SNOMED:165084003 MIO:00565 exercise tolerance test abnormal exercise ECG abnormal exercise ECG positive positive exercise ECG test MIO:00566 exercise-induced U wave inversion exercise test-induced U wave exercise-induced negative U wave exercise-induced negative U waves SNOMED:267044007 MIO:00567 impaired performance during controlled physical activity [url:http://purl.obolibrary.org/obo/MP_0012106] impaired exercise tolerance declined exercise capacity decreased exercise endurance impaired exercise endurance poor physical performance reduced exercise capacity reduced exercise endurance MP:0012107 SNOMED:703941003 MIO:00568 improved performance during controlled physical activity [url:http://purl.obolibrary.org/obo/MP_0012107] improved exercise tolerance enhanced exercise endurance improved exercise capacity prolonged exercise endurance PMID:15373990 PMID:20185982 PMID:31576177 PMID:33244274 MIO:00569 The Charlson comorbidity index predicts the one-year mortality for a patient who may have a range of comorbid conditions, such as heart disease, AIDS, or cancer (a total of 22 conditions). Each condition is assigned a score of 1, 2, 3, or 6, depending on the risk of dying associated with each one. Scores are summed to provide a total score to predict mortality. Many variations of the Charlson comorbidity index have been presented, including the Charlson/Deyo, Charlson/Romano, Charlson/Manitoba, and Charlson/D'Hoores comorbidity indices. [url:https://en.wikipedia.org/wiki/ComorbidityCharlson_index] Charlson Comorbidity Index Charlson index PMID:30683244 MIO:00570 The Chronic Disease Score was developed using medications from the pharmaceutical database instead of ICD codes to measure chronic disease status. The index includes 17 comorbid conditions that were validated against medical records and physician rating of disease severity. [url:https://pubmed.ncbi.nlm.nih.gov/30683244/] Chronic Disease Score PMID:33244274 MIO:00571 The DANCAMI included 24 comorbidities. DANish Comorbidity index for Acute Myocardial Infarction DANCAMI PMID:33244274 MIO:00572 DANish Comorbidity index for Acute Myocardial Infarction restricted to non-cardiovascular comorbidities. The rDANCAMI included 17 non-cardiovascular comorbidities. DANish Comorbidity index for Acute Myocardial Infarction restricted to non-cardiovascular comorbidities rDANCAMI PMID:33244274 MIO:00573 The Elixhauser comorbidity measure was developed using administrative data from a statewide California inpatient database from all non-federal inpatient community hospital stays in California (n = 1,779,167). The Elixhauser comorbidity measure developed a list of 30 comorbidities relying on the ICD-9-CM coding manual. The comorbidities were not simplified as an index because each comorbidity affected outcomes (length of hospital stay, hospital changes, and mortality) differently among different patients groups. The comorbidities identified by the Elixhauser comorbidity measure are significantly associated with in-hospital mortality and include both acute and chronic conditions. van Walraven et al. have derived and validated an Elixhauser comorbidity index that summarizes disease burden and can discriminate for in-hospital mortality.[9] In addition, a systematic review and comparative analysis shows that among various comorbidities indices, Elixhauser index is a better predictor of the risk especially beyond 30 days of hospitalisation. [url:https://en.wikipedia.org/wiki/ComorbidityElixhauser_comorbidity_measure] Elixhauser Comorbidity Index Elixhauser comorbidity measure PMID:9034940 MIO:00574 This measure consisted of two dimensions: (1) severity levels of 14 coexistent medical conditions, graded on a 4-point ordinal scale; and (2) a 3-point ordinal rating of the severity of 11 dimensions of physical and mental impairment. [url:https://pubmed.ncbi.nlm.nih.gov/9034940/] Greenfield Index of Coexistent Disease Greenfield's index of coexistent disease ICED DOID:162 MESH:D009369 NCIT:C9305 SNOMED:269513004 UMLS:C0006826 MIO:00575 A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. [url:http://purl.obolibrary.org/obo/DOID_162] cancer malignant neoplasm malignant tumor primary cancer DOID:1287 EFO:0000319 NCIT:C2931 SNOMED:49601007 UMLS:C0007222 MIO:00576 A disease involving the cardiovascular system. [url:http://www.ebi.ac.uk/efo/EFO_0000319] cardiovascular disease CVD cardiovascular diseases cardiovascular disorder cardiovascular disorders cardiovascular system disease disease of cardiovascular system disorder of cardiovascular system NCIT:C26729 PMID:22279115 UMLS:C0009782 MIO:00577 A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects. A non-neoplastic or neoplastic disorder that affects the connective tissue. [url:http://purl.obolibrary.org/obo/NCIT_C26729] connective tissue disease connective tissue diseases connective tissue disorders disorder of connective tissue primary disorder of connective tissue NCIT:C3009 UMLS:C0014130 MIO:00578 A non-neoplastic or neoplastic disorder that affects the endocrine system. Representative examples of non-neoplastic disorders include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency. Representative examples of neoplastic disorders include carcinoid tumor, neuroendocrine carcinoma, and pheochromocytoma. [url:http://purl.obolibrary.org/obo/NCIT_C3009] endocrine system disorder disorder of endocrine system endocrine disease endocrine diseases endocrine disorder endocrinopathy DOID:77 EFO:0010282 PMID:9034940 MIO:00579 A disease that occurs in the gastrointestinal system, excluding the hepatobiliary system. [url:http://www.ebi.ac.uk/efo/EFO_0010282] gastrointestinal disease gastroenterological system disorder gastrointestinal diseases gastrointestinal events gastrointestinal system disease gastrointestinal system disorder EFO:0005803 MESH:D006402 MONDO:0005570 NCIT:C26323 UMLS:C0018939 MIO:00580 A disease involving the hematopoietic system. [url:http://www.ebi.ac.uk/efo/EFO_0005803] hematologic disease blood disease blood disorder blood dyscrasia disease of hematopoietic system disease of the blood and blood-forming organs disease or disorder of hematopoietic system disorder of hematopoietic system haematological system disease haematological system disorder hematologic and lymphocytic disorder hematologic diseases hematologic disorder hematological disease hematological disorder hematological system disease hematological system disorder hematopoietic disease hematopoietic system disease hematopoietic system disease or disorder rare hematologic disease MIO:00581 A disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. It can be transmitted by direct or indirect contact. [url:http://www.ebi.ac.uk/efo/EFO_0005741] infectious disease clinical infection communicable disease disease by infectious agent disorder due to infection infection infections infectious infectious diseases and manifestations infectious disorder transmissible disease NCIT:C3149 PMID:22537796 PMID:9034940 UMLS:C4014900 MIO:00582 A neoplastic or non-neoplastic condition affecting the kidney. Representative examples of non-neoplastic conditions include glomerulonephritis and nephrotic syndrome. Representative examples of neoplastic conditions include benign processes (e.g., renal lipoma and renal fibroma) and malignant processes (e.g., renal cell carcinoma and renal lymphoma). [url:http://purl.obolibrary.org/obo/NCIT_C3149] kidney disorder kidney disease nephropathy renal disease renal disorder DOID:850 EFO:0003818 MONDO:0005275 MeSH:D008171 MIO:00583 A disease involving the lung. [url:http://www.ebi.ac.uk/efo/EFO_0003818] lung disease DIS PULM LUNG DIS PULM DIS disease of lung disease or disorder of lung disorder of lung lung disease or disorder lung diseases lung disorders pulmonary disease pulmonary diseases pulmonary disorders SNOMED:75934005 MIO:00584 metabolic disease metabolic diseases metabolic disorder metabolic disorders EFO:0000618 MESH:D009422 MONDO:0005071 NCIT:C26835 UMLS:C0027765 MIO:00585 A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves. [url:http://www.ebi.ac.uk/efo/EFO_0000618] nervous system disease disease of nervous system disease or disorder of nervous system disorder of nervous system nervous system disease nervous system disease or disorder nervous system disorder neurologic disease neurologic disorder neurological disease neurological disorder neurological problem NCIT:C2893 PMID:20031840 UMLS:C0004936 MIO:00586 A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia. [url:http://purl.obolibrary.org/obo/NCIT_C2893] psychiatric disorder disease of mental health mental disorder mental dysfunction mental illness psychiatric disease psychiatric disorders NCIT:C26871 PMID:9034940 UMLS:C0035204 MIO:00587 A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma. [url:http://purl.obolibrary.org/obo/NCIT_C26871] respiratory system disorder disorder of respiratory system respiratory problem respiratory problems respiratory dysfunction respiratory system disorders unspecified respiratory problem PMID:25130788 MIO:00588 Contrast-induced acute kidney injury (CI-AKI) may occur in 2–25% of patients undergoing percutaneous coronary intervention (PCI).[url:https://pubmed.ncbi.nlm.nih.gov/25130788/] contrast-induced acute kidney injury CI-AKI MIO:00589 embolic complication NCIT:C50577 UMLS:C4227568 MIO:00590 Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. [url:http://purl.obolibrary.org/obo/NCIT_C50577] heart failure HF cardiac failure NCIT:C26791 MIO:00591 The presence of extravascular erythrocytes. In medicine, loss of blood from damaged blood vessels. A hemorrhage may be internal or external, and usually involves a lot of bleeding in a short time. Loss of blood. The loss of blood from a ruptured blood vessel. In medicine, loss of blood from damaged blood vessels. A hemorrhage may be internal or external, and usually involves excessive bleeding in a short time. [url:http://purl.obolibrary.org/obo/NCIT_C26791] hemorrhage bleeding bleeding complication bleeding complications bleeding event bleeding events bleedings haemorrhage hemorrhagic complication major bleeding major bleedings MIO:00592 ischemic complication NCIT:C157906 MIO:00593 In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of the heart. This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling). The injury is typically due to acute myocardial infarction (usually transmural or ST segment elevation infarction), but may be from a number of causes that result in increased pressure or volume, causing pressure overload or volume overload (forms of strain) on the heart. Chronic hypertension, congenital heart disease with intracardiac shunting, and valvular heart disease may also lead to remodeling. After the insult occurs, a series of histopathological and structural changes occur in the left ventricular myocardium that lead to progressive decline in left ventricular performance. Ultimately, ventricular remodeling may result in diminished contractile (systolic) function and reduced stroke volume. [url:https://en.wikipedia.org/wiki/Ventricular_remodeling] left ventricular remodeling LV remodeling LV remodelling LVR adverse LV remodeling adverse left ventricular remodeling adverse remodelling cardiac remodeling left ventricle remodeling left ventricular remodelling ventricular remodeling PMID:34126755 MIO:00594 Mechanical complications of AMI are high-acuity and time-sensitive conditions associated with high morbidity and mortality rates. [url:https://pubmed.ncbi.nlm.nih.gov/34126755/] mechanical complication mechanical complications TXPO:0003292 MIO:00595 Mcrovascular dysfunction is a subtype of organ malfunction: A process that does not perform microvascular function correctly or not functioning at all. [url:http://purl.obolibrary.org/obo/TXPO_0003292] microvascular dysfunction coronary microvascular dysfunction coronary microvascular impairment DOID:0060903 MESH:D013927 NCIT:C26891 MIO:00596 The formation of a blood clot in the lumen of a vessel or heart chamber; causes include coagulation disorders and vascular endothelial injury. [url:http://purl.obolibrary.org/obo/NCIT_C26891] thrombosis blood clot thrombus thrombus formation NCIT:C111655 UMLS:C0242973 MIO:00597 Impairment of the ventricle to either fill or eject adequately. [url:http://purl.obolibrary.org/obo/NCIT_C111655] ventricular dysfunction HP:0030149 NCIT:C50482 PMID:12459082 PMID:21264440 PMID:34245691 PMID:34352369 SNOMED:89138009 MIO:00598 The leading cause of death in MI patients is cardiogenic shock (CGS), with an incidence of approximately 7%.[url:https://thoracickey.com/complications-of-myocardial-infarction/] The most severe clinical expression of left ventricular failure and is associated with extensive damage to the left ventricular myocardium after acute myocardial infarction, unrelated to a mechanical defect such as ventricular septal or papillary muscle rupture. Shock is defined as systolic BP < 90 mmHg and organ hypoperfusion. [url:http://id.who.int/icd/entity/147717581] cardiogenic shock cardiac shock DOID:118 HP:0001698 MESH:D010490 NCIT:C3319 SNOMED:373945007 UMLS:C0031039 MIO:00599 Pericardial effusion is an abnormal accumulation of fluid in the pericardial sac. Noninflammatory diseases such as chronic renal failure, circulatory congestion, hypothyroidism and amyroidosis can cause pericardial effusion. [url:http://id.who.int/icd/entity/2002014072] pericardial effusion PE fluid around heart pericardial effusions DOID:552 ICD11:CA40 MSH:D011014 NCIT:C3333 PMID:6700130 PMID:8533841 SNOMED:233604007 UMLS:C0032285 MIO:00600 A disease of the lungs, frequently but not always caused by an infection with bacteria, virus, fungus, or parasite. This disease is characterised by fever, chills, cough with sputum production, chest pain and shortness of breath. Confirmation is by chest x-ray. [url:http://id.who.int/icd/entity/142052508] pneumonia DOID:9352 EFO:0001360 ICD11:5A11 MESH:D003924 NCIT:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 PMID:28261283 UMLS:C0011860 MIO:00601 Diabetes mellitus type 2 (formerly noninsulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes) is a metabolic disorder that is characterised by high blood glucose in the context of insulin resistance and relative insulin deficiency. [url:http://id.who.int/icd/entity/119724091] type 2 diabetes mellitus NIDDM T2DM non-insulin-dependent diabetes mellitus type 2 diabetes type II diabetes mellitus DOID:115 HP:0033415 ICD11:BB23 MESH:D002305 NCIT:C50481 PMID:1898952 SNOMED:35304003 UMLS:C0007177 MIO:00602 Cardiac tamponade is a clinical syndrome caused by the accumulation of fluid in the pericardial space, resulting in reduced ventricular filling and subsequent hemodynamic compromise. Cardiac tamponade is a medical emergency, the complications of which include shock, and death. [url:http://id.who.int/icd/entity/216782575] cardiac tamponade Rose's tamponade pericardial Tamponade DOID:13139 NCIT:C35444 PMID:3790385 SNOMED:236398000 UMLS:C0403416 MIO:00603 A histopathologic term for a pattern of diseases characterized by extensive crescent formation in the glomeruli; patients present clinically with rapid deterioration of renal function, and possible progression to end-stage renal failure within weeks or months. [url:http://purl.obolibrary.org/obo/NCIT_C35444] crescentic glomerulonephritis DOID:10507 ICD11:BA60.0 UMLS:C0152107 MIO:00604 A condition of postmyocardial infarction (1 to 8 weeks), characterised by a set of associated symptom, including malaise, fever, pericardial discomfort, leukocytosis, an elevated sedimentation rate, and a pericardial effusion. Patients with this syndrome usually demonstrate localised fibrous pericarditis containing polymorphonuclear leukocytes. [url:http://id.who.int/icd/entity/1353640147] dressler's syndrome dressler syndrome post-myocardial infarction pericarditis postmyocardial infarction syndrome DOID:12842 ICD11:8C01.0 MESH:D020275 NCIT:C116345 OMIM:139393 PMID:12821231 PMID:21088346 PMID:24099761 PMID:25722582 PMID:3103829 PMID:8162787 SNOMED:16064651000119108 UMLS:C0018378 MIO:00605 A rapidly progressive autoimmune disorder of the peripheral nervous system characterized by limb paresthesias, areflexia, and generalized muscle weakness or paralysis that often begins in the legs and spreads to the arms, torso, and face. [url:http://purl.obolibrary.org/obo/NCIT_C116345] Guillain-Barre syndrome acute infective polyneuritis acute inflammatory demyelinating polyradiculopathy acute postinfectious polyneuropathy infectious neuronitis post-infectious polyneuritis postinfectious polyneuritis ICD11:4A44.B PMID:24249963 MIO:00606 Leukocytoclastic vasculitis (hypersensitivity vasculitis; hypersensitivity angiitis) is a histopathological term commonly used to denote a small-vessel vasculitis. It may be localised to the skin or may manifest in other organs. The internal organs affected most commonly include the joints, the gastrointestinal tract, and the kidneys. The prognosis is good in the absence of internal involvement. Leukocytoclastic vasculitis has many causes including infections, drugs and systemic autoimmune diseases but no cause is identified in up to 50% of patients with this condition. [url:http://id.who.int/icd/entity/748282847] leucocytoclastic vasculitis DOID:1787 HP:0001701 ICD11:BA60.1 MESH:D010493 MSH:D010493 NCIT:C34915 PMID:18560293 PMID:31359060 PMID:4579706 PMID:8417527 SNOMED:3238004 UMLS:C0031046 MIO:00607 Inflammation of the sac-like covering around the heart (pericardium).[url:http://purl.obolibrary.org/obo/HP_0001701] An inflammation of the pericardium that can produce chest pain, which occurs as early as the first day and as late as 6 weeks after acute myocardial infarction. The pain of pericarditis radiates to either trapezius ridge. Transmural myocardial infarction is responsible for local pericardial inflammation. Transient pericardial friction rubs are relatively common in patients with transmural infarction within the first 48 hours. An acute fibrinous pericarditis occurs commonly after transmural infarction, whereas the risk of haemorrhagic pericarditis is increased by anticoagulation. [url:http://id.who.int/icd/entity/910277130] pericarditis swelling or irritation of membrane around heart ICD11:4A85.03 PMID:2021968 MIO:00608 Serum sickness–like reactions (SSLRs) refer to adverse reactions that have symptoms similar to those of serum sickness (type III immune complex hypersensitivity) but in which immune complexes are not found. [url:https://en.wikipedia.org/wiki/Serum_sickness-like_reaction] serum sickness-like reaction serum-sickness-like illness OAE:0001473 MIO:00609 a troponin level abnormal AE that has an outcome of an increased amount of troponin, a protein released when the heart muscle is damaged [url:http://purl.obolibrary.org/obo/OAE_0001473] troponin level increased blood cardiac troponin increased cardiac troponin elevation elevated troponin troponin elevation SNOMED:160303001 MIO:00610 family history of diabetes mellitus FH: diabetes mellitus family history: diabetes mellitus NCIT:C66921 MIO:00611 A record of a patient's medical background regarding cardiovasular disease. [url:http://purl.obolibrary.org/obo/NCIT_C66921] cardiovascular history cardiac history history of cardiovascular disease previous cardiovascular disease SCDO:1000340 MIO:00612 A record of an individual's history of stroke(s) and associated symptoms such as slurred speech, double vision, loss of vision, and paralysis. [url:http://purl.obolibrary.org/obo/SCDO_1000340] history of stroke previous stroke prior stroke SNOMED:161445009 MIO:00613 history of diabetes mellitus history of diabetes previous diabetes mellitus prior diabetes mellitus SNOMED:161451004 MIO:00614 history of gout SNOMED:16864911000119103 MIO:00615 history of intracranial hemorrhage history of intracranial haemorrhage previous intracranial haemorrhage SNOMED:161515009 MIO:00616 history of subarachnoid hemorrhage history of subarachnoid haemorrhage NCIT:C16273 MIO:00617 Consumption of liquids containing ethanol, including the behaviors associated with drinking the alcohol. [url:http://purl.obolibrary.org/obo/NCIT_C16273] alcohol consumption alcohol drinking behavior alcohol intake alcohol use consumption of alcohol intake of alcohol EFO:0004318 NCIT:C154329 PMID:29083808 SCDO:0001079 MIO:00618 The act of puffing and/or inhaling the combustion products of a substance so as to be tasted and absorbed into the bloodstream. [url:http://purl.obolibrary.org/obo/NCIT_C154329] smoking GECKO:0000091 MIO:00619 A treatment history that is about any non-pharamacological treatments such as surgery or physical therapy. [url:http://purl.obolibrary.org/obo/GECKO_0000091] non-pharmacological treatment history NCIT:C81246 MIO:00620 A description of an individual's current and past use and/or abuse of drugs and chemicals. This includes prescription medication, illicit drugs and recreational substances. [url:http://purl.obolibrary.org/obo/NCIT_C81246] prescription drug history drug use history history of drug therapy HP:0033113 MIO:00621 In the normal heart cycle, two heart sounds can be heard by auscultation per cycle: S1 and S2. A gallop rhythm refers to the presence of three or four heart sounds per cardiac cycle, which is said to resemble the gallop of a horse. [url:http://purl.obolibrary.org/obo/HP_0033113] gallop rhythm triple rhythm PMID:33725969 MIO:00622 Frothy pink sputum may indicate more severe pulmonary edema. Antibiotics may not be necessary at this time. [url:https://en.wikipedia.org/wiki/Sputum] frothy pink sputum pink bubble sputum cough pink foam sputum pink foaming sputum pink frothy sputum whooping cough pink foam process HP:0002105 ICD11:MD22 MSH:D006469 NCIT:C3094 PMID:23489823 PMID:29944595 SNOMED:6686005 UMLS:C0019079 MIO:00623 Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs. [url:http://purl.obolibrary.org/obo/HP_0002105] hemoptysis coughing up Blood haemoptysis SNOMED:413532003 MIO:00624 blood-loss anemia anemia due to blood loss DOID:13121 SNOMED:191125001 UMLS:C0041782 MIO:00625 deficiency anaemia deficiency anemia EUPATH:0000215 MIO:00626 An anemia with hemoglobin levels less than 5 gm/dL. [url:http://purl.obolibrary.org/obo/EUPATH_0000215] severe anaemia severe anemia MIO:00627 duration of angina pectoris CVDO:0000511 MIO:00628 An angina that is not unstable. [url:http://purl.obolibrary.org/obo/CVDO_0000511] stable angina pectoris stable angina NCIT:C66911 MIO:00629 Angina pectoris (or equivalent type of ischemic discomfort) which has recently changed in frequency, duration, intensity, or occurs at rest. A condition in which there is angina pectoris that occurs without stress or activity, or with decreasing stress or activity compared with stable angina, and has been present for less than 2 wks. [url:http://purl.obolibrary.org/obo/NCIT_C66911] unstable angina UA unstable angina pectoris HP:0001662 ICD11:MC81.1 MSH:D001919 NCIT:C37920 PMID:30341846 SNOMED:48867003 UMLS:C0428977 MIO:00630 A slower than normal heart rate (in adults, slower than 60 beats per minute). [url:http://purl.obolibrary.org/obo/HP_0001662] bradycardia bradyarrhythmia bradyarrhythmias bradyrhythmia slow heartbeats HP:0001695 ICD11:MC82 MSH:D006323 NCIT:C50479 PMID:29243857 SNOMED:410429000 UMLS:C0018790 MIO:00631 An abrupt loss of heart function. [url:http://purl.obolibrary.org/obo/HP_0001695] cardiac arrest arrhythmic cardiac arrest heart stops beating HP:0012722 NCIT:C34665 PMID:11136486 PMID:1575181 PMID:29050735 PMID:5552078 SNOMED:233916004 MIO:00632 Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway. [url:http://purl.obolibrary.org/obo/HP_0012722] heart block NCIT:C62239 PMID:5307390 SNOMED:427393009 MIO:00633 Sinus arrhythmia is a commonly encountered variation of normal sinus rhythm. Sinus arrhythmia characteristically presents with an irregular rate in which the variation in the R-R interval is greater than 0.12 seconds. [url:https://en.wikipedia.org/wiki/Sinus_arrhythmia] sinus arrhythmia HP:0005115 NCIT:C27158 PMID:2440643 SNOMED:72654001 UMLS:C0428974 MIO:00634 A type of arrhythmia that originates above the ventricles, whereby the electrical impulse propagates down the normal His Purkinje system similar to normal sinus rhythm. [url:http://purl.obolibrary.org/obo/HP_0005115] supraventricular arrhythmia HP:0001649 MSH:D013610 NCIT:C38029 PMID:33335633 SNOMED:3424008 UMLS:C0039231 MIO:00635 An abnormally rapid heart rate. Thresholds for different age, gender, and patient populations exist. [url:http://purl.obolibrary.org/obo/NCIT_C38029] tachycardia tachyarrhythmia tachyarrhythmias HP:0004308 NCIT:C26924 PMID:29018522 PMID:30234552 PMID:30371294 PMID:850804 SNOMED:44103008 UMLS:C0085612 MIO:00636 A disorder characterized by an electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles. [url:http://purl.obolibrary.org/obo/NCIT_C26924] ventricular arrhythmia VA ventricular arrhythmias ventricular arrythmias ventricular heart rhythm disorders ventricular rhythm disturbances PMID:22816542 PMID:22950360 MIO:00637 Turbulence onset (TO,%), slope (TS, ms/RR interval) and timing (TT) were calculated. TO ≥ 0, TS ≤ 2.5 and TT ≥ 10 were considered abnormal. [url:https://pubmed.ncbi.nlm.nih.gov/22816542/] abnormal heart rate turbulence HRT positive abnormal HRT positive HRT HP:0031861 MIO:00638 Reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle. [url:http://purl.obolibrary.org/obo/HP_0031861] decreased heart rate variability depressed heart rate variability depressed HRV impaired HRV impaired heart rate variability reduced heart rate variability PMID:29765434 MIO:00639 The term electrical storm (ES) was used for the first time in the early 1990s and was defined as a state of high electrical instability of the heart, which is manifested by numerous episodes of ventricular tachycardia (VT)/ventricular fibrillation (VF) within a short period of time. Electrical storms are associated with a very high mortality (80–90%) both during the incident alone and during further observation. [url:https://pubmed.ncbi.nlm.nih.gov/29765434/] electrical storm HP:0001962 ICD11:MC81.2 NCIT:C37999 PMID:34046479 SNOMED:80313002 UMLS:C0030252 MIO:00640 A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia. [url:http://purl.obolibrary.org/obo/HP_0001962] palpitations heart palpitations missed heart beat palpitation skipped heart beat MIO:00641 In the clinical setting, reperfusion induced arrhythmias include accelerated idioventricular rhythms, ventricular fibrillation, and acute sinus bradycardia combined with hypotension in inferior infarcts. In addition, they are usually accompanied by disappearance of angina pectoris and an abrupt decrease in ST-segment elevation. The occurrence of ventricular arrhythmias during thrombolytic therapy may indicate the time of reperfusion. [url:https://www.sciencedirect.com/science/article/abs/pii/S0268949908800185] reperfusion arrhythmias reperfusion induced arrhythmias reperfusion ventricular arrhythmia HP:0031246 NCIT:C173623 PMID:12087893 SNOMED:11833005 MIO:00642 A cough that does not produce phlegm or mucus. [url:http://purl.obolibrary.org/obo/HP_0031246] dry cough dry coughing non-productive cough NCIT:C117162 MIO:00643 Disturbed mental state characterized by moodiness, irritability, agitation, anxiety, and/or depression resulting from physical or mental stress. [url:http://purl.obolibrary.org/obo/NCIT_C117162] emotional distress SNOMED:87383005 MIO:00644 Mental distress (or psychological distress) is a term used, by some mental health practitioners and users of mental health services, to describe a range of symptoms and experiences of a person's internal life that are commonly held to be troubling, confusing or out of the ordinary. Mental distress can potentially lead to a change of behavior, affect a person's emotions in a negative way, and affect their relationships with the people around them. [url:https://en.wikipedia.org/wiki/Mental_distress] mental distress psychological distress HP:0007430 NCIT:C143202 SNOMED:271808008 UMLS:C1850534 MIO:00645 Generalized abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body. [url:http://purl.obolibrary.org/obo/HP_0007430] generalized edema generalised oedema generalised tissue oedema generalized tissue edema HP:0010741 NCIT:C80306 SNOMED:102572006 UMLS:C0235886 UMLS:C0239340 MIO:00646 An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg. [url:http://purl.obolibrary.org/obo/HP_0010741] pedal edema dependant edema dependant oedema edema of the lower limbs fluid accumulation in lower limbs leg edema leg oedema leripheral oedema of lower extremity lower leg swelling oedema of the lower limbs pedal oedema peripheral edema of lower extremity EFO:1001340 MIO:00647 A reaction to prolonged exposure to high temperatures that can result in a failure of the body's temperature control system. It is often characterized by body temperature over 105 degrees, dehydration, headache, dizziness, nausea, vomiting, and muscle weakness. [url:http://purl.obolibrary.org/obo/NCIT_C35047] heat stroke heat apoplexy sun stroke thermoplegia HP:0002607 ICD11:ME07 MSH:D005242 NCIT:C78498 PMID:431704 SNOMED:72042002 UMLS:C0015732 MIO:00648 Involuntary passage of stool from the rectum. [url:http://purl.obolibrary.org/obo/NCIT_C78498&ns=ncit] fecal incontinence anal incontinence faecal incontinence loss of bowel control HP:0000020 ICD11:MF50.2 MSH:D014549 NCIT:C78497 PMID:11499737 SNOMED:165232002 UMLS:C0042024 MIO:00649 Loss of the ability to control the urinary bladder leading to involuntary urination. [url:http://purl.obolibrary.org/obo/HP_0000020] urinary incontinence bladder incontinence loss of bladder control HP:0100749 MSH:D002637 PMID:16020420 PMID:29083808 PMID:30807351 SNOMED:29857009 UMLS:C0008031 MIO:00650 Early and rapid ECG testing should be employed in all patients presenting with chest pain.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] Chest pain is the most common symptom of acute myocardial infarction and is often described as a sensation of tightness, pressure, or squeezing. [url:https://en.wikipedia.org/wiki/Myocardial_infarctionSigns_and_symptoms] chest pain chest discomfort thoracic pain typical chest symptom typical symptom HP:0002094 ICD11:MD11.5 MSH:D004417 PMID:11182180 PMID:12087893 PMID:16020420 PMID:26872739 PMID:29083808 PMID:29243857 PMID:30807351 SNOMED:230145002 UMLS:C0013404 MIO:00651 Elderly patients more often have shortness of breath as their presenting symptom for myocardial infarction.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] Dyspnoea is used to describe perceptions of difficulty or distress related to breathing and is recognised as symptomatic of disease when it occurs under inappropriate circumstances. Dyspnoea is a presenting complaint of patients with a wide variety of medical diseases by multiple mechanisms. [url:http://id.who.int/icd/entity/960305085] dyspnoea abnormal breathing breathing difficulty difficult to breathe difficulty breathing dyspnea labored breath panting respiratory distress shortness of breath trouble breathing HP:0012378 ICD11:MG22 MSH:D005221 NCIT:C3036 PMID:16020420 PMID:30064979 PMID:5212358 SNOMED:84229001 UMLS:C0015672 MIO:00652 A feeling of exhaustion, lethargy, or decreased energy, usually experienced as a weakening or depletion of one's physical or mental resource and characterised by a decreased capacity for work and reduced efficiency in responding to stimuli. Fatigue is normal following a period of exertion, mental or physical, but sometimes may occur in the absence of such exertion as a symptom of health conditions. [url:http://id.who.int/icd/entity/1109546957] fatigue tired tiredness HP:0001262 MIO:00653 A state of abnormally strong desire for sleep during the daytime. [url:http://purl.obolibrary.org/obo/HP_0001262] excessive daytime somnolence excessive daytime sleepiness more than typical sleepiness during day NCIT:C28286 MIO:00654 A sleep disorder characterized by difficulty in falling asleep and/or remaining asleep. [url:http://purl.obolibrary.org/obo/NCIT_C28286] insomnia HP:0010535 MIO:00655 An intermittent cessation of airflow at the mouth and nose during sleep. Apneas of at least 10 seconds are considered important, but persons with sleep apnea may have apneas of 20 seconds to up to 2 or 3 minutes. Patients may have up to 15 events per hour of sleep. [url:http://purl.obolibrary.org/obo/HP_0010535] sleep apnoea pauses in breathing while sleeping HP:0025267 MIO:00656 Deep, noisy breathing during sleep accompanied by hoarse or harsh sounds caused by the vibration of respiratory structures (especially the soft palate) resulting in sound due to obstructed air movement during breathing while sleeping. [url:http://purl.obolibrary.org/obo/HP_0025267] snoring snore snores snoring symptoms NCIT:C3445 PMID:30563358 UMLS:C1262477 MIO:00657 The prevention and treatment of overweight and obesity is a major therapeutic lifestyle change of proven benefit in the primary prevention of MI and stroke.[url:https://pubmed.ncbi.nlm.nih.gov/30563358/] A reduction in total body weight. [url:http://purl.obolibrary.org/obo/NCIT_C3445] weight loss weight decrease NCIT:C62754 MIO:00658 An increase in total body weight. [url:http://purl.obolibrary.org/obo/NCIT_C62754] weight gain BWGAIN body weight gain weight increase NCIT:C16342 MIO:00659 A defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Molecular, histologic, radiographic, or physiologic characteristics are types of biomarkers. A biomarker is not an assessment of how an individual feels, functions, or survives. Categories of biomarkers include: susceptibility/risk biomarker; diagnostic biomarker; monitoring biomarker; prognostic biomarker; predictive biomarker; safety biomarker; pharmacodynamic/response biomarker. [url:http://purl.obolibrary.org/obo/NCIT_C16342] biomarker biological marker biological markers biomarkers marker markers signature molecule PMID:31127678 MIO:00660 This classification scheme is based on bedside evaluation and categorization by clinical signs of congestion (‘wet’ vs. ‘dry’ if present vs. absent) and hypoperfusion (‘cold’ vs. ‘warm’ if present vs. absent),1 to allow differentiation into four distinct profiles: ‘wet-warm’ – patients demonstrating congestion and adequate peripheral perfusion; ‘wet-cold’ – with congestion and hypoperfusion; ‘dry-cold’ – free of congestion but with hypoperfusion; and ‘dry-warm’ – free of either congestion or hypoperfusion. [url:https://pubmed.ncbi.nlm.nih.gov/31127678/] forrester class forrester classification forrester grade NCIT:C66916 UMLS:C1881332 MIO:00661 A finding associated with a patient based on the classification developed by Killip and Kimball, which classifies patients with myocardial infarction based on routine physical examination parameters, such as the presence or absence of rales, or a decreased systolic blood pressure. [url:http://purl.obolibrary.org/obo/NCIT_C66916] Killip class KILLIPCL Killip Classification Killip Classification Scale Killip grade NCIT:C66909 MIO:00662 A finding associated with a patient based on the functional classification developed by the New York Heart Association (NYHA), for categorizing patients with defined or presumed cardiac disease. The classification system is based on the ability, or lack thereof, to engage in physical activity. The classification system comprises four classes, though NYHA Class III and Class IV are often aggregated for the purpose of outcomes analysis. [url:http://purl.obolibrary.org/obo/NCIT_C66909] New York Heart Association class NYHA class NYHACLS PMID:19506110 MIO:00663 A risk model limited to 3 independent predictors has similar or better accuracy and calibration compared with more complex risk scores if applied to elective cardiac operations.[url:https://pubmed.ncbi.nlm.nih.gov/19506110/] The ACEF score was computed as follows: age (years)/ejection fraction (%)+1 (if serum creatinine value was >2 mg/dL). [url:https://pubmed.ncbi.nlm.nih.gov/19506110/] ACEF score ACEF risk score PMID:23703775 MIO:00664 Advanced age, depressed EF, and reduced eGFR are independent predictors of Contrast-Induced Nephropathy (CIN) development after primary PCI for STEMI. The preprocedural individual patient risk can be clinically assessed with the calculation of the AGEF score, which is based on such readily available parameters. AGEF score was calculated by adding 1 point to the Age/EF(%) ratio if the eGFR was <60 mL/min per 1.73 m(2) . [url:https://pubmed.ncbi.nlm.nih.gov/23703775/] AGEF score AGEF risk score MIO:00665 The ASA physical status classification system is a system for assessing the fitness of patients before surgery. In 1963 the American Society of Anesthesiologists (ASA) adopted the five-category physical status classification system; a sixth category was later added. These are: 1. Healthy person. 2. Mild systemic disease. 3. Severe systemic disease. 4. Severe systemic disease that is a constant threat to life. 5. A moribund person who is not expected to survive without the operation. 6. A declared brain-dead person whose organs are being removed for donor purposes. [url:https://en.wikipedia.org/wiki/ASA_physical_status_classification_system] American Society of Anesthesiologists physical status class ASA physical status classification system American Society of Anesthesiologists (ASA) physical status classification scale American Society of Anesthesiologists class American Society of Anesthesiologists physical status classification scale PMID:3928249 MIO:00666 APACHE II uses a point score based upon initial values of 12 routine physiologic measurements, age, and previous health status to provide a general measure of severity of disease. [url:https://pubmed.ncbi.nlm.nih.gov/3928249/] APACHE II APACHE II score APACHE II system APACHE-II Acute Physiology and Chronic Health Evaluation (APACHE) II score NCIT:C131914 SNOMED:273302005 UMLS:C0451019 MIO:00667 A clinical assessment tool designed to measure functional independence and need for assistance in mobility, self-care, and activities of daily living. [url:http://purl.obolibrary.org/obo/NCIT_C131914] Barthel index Barthel ADL index Barthel activities of daily living (ADL) index Barthel index of ADL Barthel index of activities of daily living Barthel scale PMID:15862409 MIO:00668 In AMI patients treated with primary PCI, seven risk factors readily available at the time of intervention accurately predict short- and long-term mortality. The components of CADILLAC risk score are as follows: age >65 years [2 points], Killip class 2/3 [3 points], baseline left ventricular ejection fraction <40% [4 points], anemia [2 points], renal insufficiency [3 points], triple-vessel disease [2 points], and post-procedural Thrombolysis In Myocardial Infarction flow grade [2 points]. CADILLAC risk score CADILLAC score NCIT:C100074 MIO:00669 The relative risk of developing ischemia determined by a cardiac stress test. (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C100074] cardiac ischemic risk score SNOMED:713678009 MIO:00670 The components of CHA2DS2-VASc score include congestive heart failure (1 point), hypertension (1 point), age (>75 years [2 points]), diabetes mellitus (1 point), history of stroke or transient ischemic attack (2 points), history of vascular disease (1 point), age (>65 years [1 point]), female gender (1 point). [url:https://en.wikipedia.org/wiki/CHA2DS2%E2%80%93VASc_scoreCHA2DS2-VASc] CHA2DS2-VASc score congestive heart failure, hypertension, age 75 years or older, diabetes, previous stroke or transient ischemic attack, vascular disease, age 65-74 years, and sex category risk score MIO:00671 The components of CHADS2 score are as follows: congestive heart failure (1 points), hypertension (1 points), age >75 years (1 points), diabetes mellitus (1 points), and history of stroke (2 points). [url:https://en.wikipedia.org/wiki/CHA2DS2%E2%80%93VASc_scoreCHADS2] CHADS2 score CHADS2 risk score PMID:19628105 MIO:00672 Gensini score is a widely used means of quantifying angiographic atherosclerosis, where a zero score indicates absence of atherosclerotic disease. The Gensini score accounts for the degree of artery narrowing as well as locations of narrowing. [url:https://en.wikipedia.org/wiki/Gensini_score] Gensini score PMID:18572028 MIO:00673 The Global Registry for Acute Coronary Events (GRACE) score, based on a large registry of patients across the entire spectrum of acute coronary syndromes, also incorporates clinical and electrocardiographic characteristics. [url:https://pubmed.ncbi.nlm.nih.gov/18572028/] GRACE risk score GRACE score Global Registry for Acute Coronary Events (GRACE) risk scores Global Registry for Acute Coronary Events (GRACE) score PMID:15187054 MIO:00674 The risk-prediction tool for all forms of acute coronary syndrome (ACS) identified 9 variables predictive of 6-month mortality: older age, history of myocardial infarction, history of heart failure, increased pulse rate at presentation, lower systolic blood pressure at presentation, elevated initial serum creatinine level, elevated initial serum cardiac biomarker levels, ST-segment depression on presenting electrocardiogram, and not having a percutaneous coronary intervention performed in hospital. [url:https://pubmed.ncbi.nlm.nih.gov/15187054/] PAMI risk score PAMI score Primary Angioplasty in Myocardial Infarction (PAMI) risk score PMID:28290994 MIO:00675 The risk of bleeding was calculated using the PRECISE-DAPT score. The components of PRECISE-DAPT score are as follows: age, creatinine clearance, haemoglobin, white-blood-cell count, and previous spontaneous bleeding (http://www.precisedaptscore.com/predapt/). [url:https://pubmed.ncbi.nlm.nih.gov/28290994/] PRECISE-DAPT score PRECISE-DAPT risk score PMID:7350839 MIO:00676 The prognostic nutritional index (PNI) is a combined nutritional-inflammatory score based on serum albumin levels and the lymphocyte count that reflects the immunological nutritional condition. [url:https://pubmed.ncbi.nlm.nih.gov/7350839/] prognostic nutritional index PNI SNOMED:448236008 MIO:00677 The Revised Cardiac Risk Index (RCRI) is a tool used to estimate a patient's risk of perioperative cardiac complications. The RCRI and similar clinical prediction tools are derived by looking for an association between preoperative variables (e.g., patient's age, type of surgery, comorbid diagnoses, or laboratory data) and the risk for cardiac complications in a cohort of surgical patients (the "derivation cohort"). Variables that have independent predictive value in a logistic regression analysis are incorporated into the risk index. Ideally, the accuracy and validity of the risk index is then tested in a separate cohort (the "validation cohort"). [url:https://en.wikipedia.org/wiki/Revised_Cardiac_Risk_Index] revised cardiac risk index RCRI MIO:00678 The Roxana Mehran score is a clinical prediction rule to estimate probability of nephropathy (increase ≥25% and/or ≥0.5 mg/dl in serum creatinine at 48 h): (1) Systolic blood pressure <80 mm Hg - 5 points (if systolic BP less than 80 mmHg for at least one hour requiring inotropic support) (2) Intra-arterial balloon pump - 5 points (3) Congestive heart failure, counting as NYHA class III (marked limitation in activity due to symptoms, even during less-than-ordinary activity) or worse, or history of pulmonary edema - 5 points (4) Age >75 y - 4 points (5) Hematocrit level <39% for men and <35% for women - 3 points (6) Diabetes mellitus- 3 points (7) Contrast media volume - 1 point for each 100 mL ( 8) Decreased kidney function: 1) Serum creatinine level >1.5 g/dL - 4 points or 2) Estimated Glomerular filtration rate (online calculator) a. 2 for 40–60 mL/min/1.73 m2 b. 4 for 20–40 mL/min/1.73 m2 c. 6 for < 20 mL/min/1.73 m2 [url:https://en.wikipedia.org/wiki/Contrast-induced_nephropathyRoxana_Mehran_score] Roxana Mehran score Mehran risk score Mehran score PMID:32554162 MIO:00679 The Synergy between Percutaneous Coronary Intervention (SYNTAX) score, a lesion-based angiographic scoring system, has been widely used to grade the complexity of coronary artery disease. It guides the decision-making between coronary artery bypass grafting (CABG) surgery and percutaneous coronary intervention (PCI). Among patients with low (0 to 22) and intermediate (23 to 32) SYNTAX score, the clinical outcomes were comparable with PCI and CABG, whereas, in those with a high score (≥33), outcomes were better with CABG at 12 months. Syntax score was computed using an online SYNTAX score calculator ( http://www.syntaxscore.com/calculator/start.htm). [url:https://pubmed.ncbi.nlm.nih.gov/32554162/] SYNTAX score Synergy between Percutaneous Coronary Intervention (SYNTAX) score Synergy between Percutaneous Coronary Intervention score Syntax score Syntax score I PMID:23439103 MIO:00680 SYNTAX score II contained eight predictors: anatomical SYNTAX score, age, creatinine clearance, left ventricular ejection fraction (LVEF), presence of unprotected left main coronary artery (ULMCA) disease, peripheral vascular disease, female sex, and chronic obstructive pulmonary disease (COPD). [url:https://pubmed.ncbi.nlm.nih.gov/23439103/] SYNTAX score II SS II SS-II SSII Syntax score II PMID:11044416 MIO:00681 In patients with UA/NSTEMI, the TIMI risk score is a simple prognostication scheme that categorizes a patient's risk of death and ischemic events and provides a basis for therapeutic decision making. 1) Age ≥ 65 years? Yes (+1) 2) ≥ 3 Risk Factors for CAD*? Yes (+1) 3) Known CAD (stenosis ≥ 50%)? Yes (+1) 4) ASA Use in Past 7d? Yes (+1) 5) Severe angina (≥ 2 episodes w/in 24 hrs)? Yes (+1) 6) ST changes ≥ 0.5mm? Yes (+1) 7) + Cardiac Marker? Yes (+1) *Risk factors include family history of CAD, hypertension, hypercholesterolemia, diabetes, or being a current smoker. [url:https://en.wikipedia.org/wiki/TIMITIMI_Risk_Score] TIMI risk score TIMI (Thrombolysis in Myocardial Infarction) Risk Index (TRI) TIMI model TIMI risk index TIMI score TRI Thrombolysis In Myocardial Infarction (TIMI) risk score Thrombolysis in Myocardial Infarction (TIMI) Risk Index (TRI) Thrombolysis in Myocardial Infarction (TIMI) score thrombolysis in myocardial infarction (TIMI) risk scoring system thrombolysis in myocardial infarction score CMO:0000077 MIO:00682 Any quantification of a morphological or physiological parameter of one or more blood vessels, the network of muscular tubes that carry blood through the body. [url:http://purl.obolibrary.org/obo/CMO_0000077] blood vessel measurement CMO:0000195 MIO:00683 Any measurement of the movement of blood through the heart and blood vessels. [url:http://purl.obolibrary.org/obo/CMO_0000195] circulation measurement CMO:0000670 MIO:00684 This is not the same term as the original "heart measurement". That term is now "heart morphological measurement". [url:http://purl.obolibrary.org/obo/CMO_0000670] heart measurement cardiac feature heart feature NCIT:C25749 PMID:29083808 MIO:00685 Unequal pulses if the patient has an aortic dissection.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] The rhythmic wave within the arteries occurring with each contraction of the left ventricle. [url:http://purl.obolibrary.org/obo/NCIT_C25749] pulse NCIT:C38101 MIO:00686 A radiographic procedure using the emission of x-rays to form an image of the structure penetrated by the radiation. [url:http://purl.obolibrary.org/obo/NCIT_C38101] X-ray imaging X-ray conventional X-Ray diagnostic radiology radiography NCIT:C17204 MIO:00687 A series of detailed pictures of areas inside the body; the pictures are created by a computer linked to an x-ray machine. An imaging technique for examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis. [url:http://purl.obolibrary.org/obo/NCIT_C17204] computed tomography CAT scan CT CT scan computerized axial tomography computerized tomography tomography MIO:00688 Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders. [url:http://purl.obolibrary.org/obo/NCIT_C16809] magnetic resonance imaging MR imaging MRI MRI scan NMR imaging NMRI magnetic resonance imaging scan medical imaging, nuclear magnetic resonance nuclear magnetic resonance imaging NCIT:C17007 MIO:00689 A technique for measuring the gamma radiation produced by collisions of electrons and positrons (anti-electrons) within living tissue. In positron emission tomography (PET), a subject is given a dose of a positron-emitting radionuclide attached to a metabolically active substance (for example, 2-fluoro-2-deoxy-D-glucose (FDG), which is similar to a naturally occurring sugar, glucose, with the addition of a radioactive fluorine atom). When living tissue containing the positron emitter is bombarded by electrons, gamma radiation produced by collisions of electrons and positrons is detected by a scanner, revealing in fine detail the tissue location of the metabolically-active substance administered. [url:http://purl.obolibrary.org/obo/NCIT_C17007] positron emission tomography PET PET scan positron emission tomography scan positron-emission tomography proton magnetic resonance spectroscopic imaging NCIT:C62667 MIO:00690 An imaging technique that uses a small dose of a radioactive chemical (isotope) called a tracer that can detect sites of cancer growth, trauma, infection or degenerative disorders. The tracer, which is either injected into a vein or swallowed, travels through the bloodstream to the target organ, and emits gamma rays, which are detected by a gamma camera and analyzed by a computer to form an image of the target organ. [url:http://purl.obolibrary.org/obo/NCIT_C62667] radionuclide imaging nuclear medicine scan radioimaging radionuclide scanning scintigraphy NCIT:C17230 OMIT:0015299 MIO:00691 A technique in which high-frequency sound waves are bounced off internal organs and the echo pattern is converted into a 2 dimensional picture of the structures beneath the transducer. [url:http://purl.obolibrary.org/obo/NCIT_C17230] ultrasonography 2-dimensional grayscale ultrasound imaging 2-dimensional ultrasound imaging 2d-us ultrasonography ultrasound ultrasound imaging ultrasound test ultrasound, medical us NCIT:C49237 UMLS:C0201682 MIO:00692 A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen. [url:http://purl.obolibrary.org/obo/NCIT_C49237] chemistry test chemistry measurement chemistry procedure chemistry technique NCIT:C49286 MIO:00693 A laboratory test to measure hematopoietic components and investigate hematologic disorders in a blood sample. [url:http://purl.obolibrary.org/obo/NCIT_C49286] hematology test blood measurement blood test hematological measurement hematology procedure NCIT:C16723 UMLS:C0021061 MIO:00694 Laboratory test involving interaction of antigens with specific antibodies. [url:http://purl.obolibrary.org/obo/NCIT_C16723] immunology test immunoassay immunological laboratory method NCIT:C38081 MIO:00695 A test used to measure how well the lungs work. It measures how much air the lungs can hold and how quickly air is moved into and out of the lungs. It also measures how much oxygen is used and how much carbon dioxide is given off during breathing. A PFT can be used to diagnose a lung disease and to see how well treatment for the disease is working. [url:http://purl.obolibrary.org/obo/NCIT_C38081] pulmonary function test PFT lung function test pulmonary function testing pulmonary function tests NCIT:C49672 MIO:00696 The act of assessing an individual's current temperature, heart rate, respiratory rate, pulse oxygenation, and blood pressure. [url:http://purl.obolibrary.org/obo/NCIT_C49672] vital signs vital signs vital signs test NCIT:C81328 UMLS:C0005910 MIO:00697 A measurement that describes the vertical force exerted by a mass of the patient as a result of gravity. [url:http://purl.obolibrary.org/obo/NCIT_C81328] body weight BW patient weight subject weight weight HP:0033400 MIO:00698 A sudden onset of abdominal pain with associated nausea or vomiting. The acute abdomen may be caused by an infection, inflammation, vascular occlusion, or obstruction. [url:http://purl.obolibrary.org/obo/HP_0033400] acute abdomen acute abdominal pain NCIT:C35152 PMID:18560293 UMLS:C0149520 MIO:00699 Acute inflammation of the gallbladder. [url:http://purl.obolibrary.org/obo/NCIT_C35152] acute cholecystitis NCIT:C95437 PMID:18560293 UMLS:C0001339 MIO:00700 An acute inflammatory process that leads to necrosis of the pancreatic parenchyma. Signs and symptoms include severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock. Causes include alcohol consumption, presence of gallstones, trauma, and drugs. [url:http://purl.obolibrary.org/obo/NCIT_C95437] acute pancreatitis HP:0002647 NCIT:C50461 PMID:22389656 PMID:24592567 PMID:26509348 UMLS:C0340643 MIO:00701 A progressive tear in the tissue lining the aorta, characterized by the passage of blood from the tunica intima into, and partially through, the tunica media. [url:http://purl.obolibrary.org/obo/NCIT_C50461] aortic dissection DOID:13405 NCIT:C35589 PMID:34317484 UMLS:C0392077 MIO:00702 Sarcoidosis affecting the tissues of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C35589] cardiac sarcoidosis sarcoidosis NCIT:C102629 PMID:18560293 UMLS:C1997354 MIO:00703 An electrocardiographic finding of J point and ST segment elevation in the absence of other signs of acute ischemia or pericarditis. [url:http://purl.obolibrary.org/obo/NCIT_C102629] early repolarization ERP Early Repolarization Early Repolarization Pattern Early Ventricular Repolarization NCIT:C3444 PMID:32376663 UMLS:C3495801 MIO:00704 A rare, autoimmune, systemic medium and small size vasculitis. It is characterized by the formation of necrotizing granulomas in the respiratory tract, necrotizing angiitis, and glomerulonephritis. [url:http://purl.obolibrary.org/obo/NCIT_C3444] granulomatosis with polyangiitis GPA wegener granulomatosis wegener's granulomatosis NCIT:C37968 PMID:18560293 UMLS:C0020461 MIO:00705 Higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs. [url:http://purl.obolibrary.org/obo/NCIT_C37968] hyperkalemia NCIT:C34449 PMID:11575264 UMLS:C0007194 MIO:00706 A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract. [url:http://purl.obolibrary.org/obo/NCIT_C34449] hypertrophic cardiomyopathy hypertrophic obstructive cardiomyopathy NCIT:C34831 PMID:32513516 UMLS:C0027059 MIO:00707 Inflammation of the muscle tissue of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C34831] myocarditis DOID:9477 HP:0002204 ICD11:BA60.5 MESH:D011655 NCIT:C50713 PMID:21432791 PMID:31952498 SNOMED:59282003 UMLS:C0034065 MIO:00708 A pulmonary embolism that resulted from thrombi in the veins of the lower extremities (e.g. after prolonged periods of bed rest) or mural thrombi overlying an area of right ventricular infarction after acute myocardial infarction.[url:http://id.who.int/icd/entity/847963591] The obstruction of the pulmonary artery or one of its branches by an embolus, sometimes associated with infarction of the lung. [url:http://purl.obolibrary.org/obo/NCIT_C50713] pulmonary embolism NCIT:C50757 PMID:26717338 UMLS:C0038525 MIO:00709 Intracranial hemorrhage into the subarachnoid space. [url:http://purl.obolibrary.org/obo/NCIT_C50757] subarachnoid hemorrhage subarachnoid haemorrhage NCIT:C85181 PMID:15373314 PMID:15583228 PMID:18560293 PMID:18790504 PMID:32513516 UMLS:C1739395 MIO:00710 A rare disorder characterized by transient left ventricular wall systolic dysfunction, resulting in apical ballooning appearance, chest pain, and ST segment elevation. [url:http://purl.obolibrary.org/obo/NCIT_C85181] takotsubo cardiomyopathy Ballooning cardiomyopathy TTS Tako-Tsubo cardiomyopathy Takotsubo syndrome ampulla cardiomyopathy apical ballooning syndrome broken heart syndrome broken-heart syndrome stress cardiomyopathy takotsubo syndrome transient left ventricular apical ballooning transient left ventricular apical ballooning syndrome NCIT:C78242 PMID:30123608 UMLS:C0347646 MIO:00711 A rupture in the colonic wall due to traumatic or pathologic processes. [url:http://purl.obolibrary.org/obo/NCIT_C78242] colonic perforation MONDO:0001858 MIO:00712 Idiopathic painful nonsuppurative swellings of one or more costal cartilages, especially of the second rib. The anterior chest pain may mimic that of coronary artery disease. [ MESH:D013991 ] [url:http://purl.obolibrary.org/obo/MONDO_0001858] Tietze syndrome Costochondritis Tietze's disease Tietze's syndrome costalchondritis costochondral joint syndromic disease costochondral junction syndrome slipping rib syndrome syndromic disease of costochondral joint NCIT:C16612 MIO:00713 A functional unit of heredity which occupies a specific position on a particular chromosome and serves as the template for a product that contributes to a phenotype or a biological function. [url:http://purl.obolibrary.org/obo/NCIT_C16612] gene genes NCIT:C17248 MIO:00714 Genetic Variation consists of deviation(s) in the nucleotide sequence of the genetic material of an individual from that typical of the group to which the individual belongs, or deviation(s) in the nucleotide sequence of the genetic material of offspring from that of its parents. [url:http://purl.obolibrary.org/obo/NCIT_C17248] genetic variation genetic diversity geneticvriation sequence Variation sequence variant variant classification variant_classification NCIT:C61154 MIO:00715 Any substance involved in metabolism, either as a product of metabolism or as necessary for metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C61154] metabolite NCIT:C17021 MIO:00716 A group of complex organic macromolecules composed of one or more chains (linear polymers) of alpha-L-amino acids linked by peptide bonds and ranging in size from a few thousand to over 1 million Daltons. Proteins are fundamental genetically encoded components of living cells with specific structures and functions dictated by amino acid sequence. [url:http://purl.obolibrary.org/obo/NCIT_C17021] protein proteins XCO:0000233 MIO:00717 RNA or ribonucleic acid is a polymer of nucleotides with a backbone made of ribose sugar and phosphate groups linked together by ester bonds. RNA has the base uracil instead of thymine, which is present in DNA. [url:http://www.bioassayontology.org/baoBAO_0000270] RNA ribonucleic acid NCIT:C17961 MIO:00718 The process by which methyl groups are added to nucleotides in genomic DNA. [url:http://purl.obolibrary.org/obo/NCIT_C17961] DNA methylation DNA methylation process DNA-methylation NCIT:C51946 MIO:00719 The determination of the number of erythrocytes in a biospecimen. [url:http://purl.obolibrary.org/obo/NCIT_C51946] erythrocyte count RBC erythrocyte count erythrocytes red blood cell count red blood cells red cell count EFO:0005208 NCIT:C110935 UMLS:C3811844 MIO:00720 A laboratory test that estimates kidney function. It is calculated using an individual's serum creatinine measurement, age, gender, and race. Actual results are reported when the estimated glomerular filtration rate is less than 60 ml/min. [url:http://purl.obolibrary.org/obo/NCIT_C110935] estimated glomerular filtration rate GFR GFRE eGFR glomerular filtration rate NCIT:C51948 UMLS:C0023508 MIO:00721 A measurement of the leukocytes in a biological specimen.; Concentration of leukocytes in the peripheral blood stream, expressed as WBCs per milliliter of whole blood. [url:http://purl.obolibrary.org/obo/NCIT_C51948] leukocyte count WBC WBC count leukocyte leukocytes white blood cell count white blood cells white cell count HP:0011877 MIO:00722 Mean platelet volume (MPV) is a measure of the average size of platelets, with a typical reference range of 7.5 to 11.5 femtoliters (fL).[url:http://purl.obolibrary.org/obo/HP_0011877] Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems. [url:https://en.wikipedia.org/wiki/Mean_platelet_volume] mean platelet volume MPV MI:0681 MIO:00723 DNA that consists of two base pairing strands. The 2 nucleotide chains are held together by hydrogen bonds between base pairs of nucleotides. [ http://www.ncbi.nlm.nih.gov/pubmed/14755292 ] double stranded deoxyribonucleic acid DsDNA NCIT:C51951 UMLS:C0032181 MIO:00724 The determination of the number of platelets in a blood sample, usually expressed as platelets per milliliter of whole blood. A measurement of the platelets (non-nucleated thrombocytes) in a biological specimen. [url:http://purl.obolibrary.org/obo/NCIT_C51951] platelet count PLAT anucleated thrombocytes platelets EFO:0009188 SCDO:1000638 MIO:00725 Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood count. Usually red blood cells are a standard size of about 6-8 μm in diameter. Certain disorders, however, cause a significant variation in cell size. Higher RDW values indicate greater variation in size. Normal reference range of RDW-CV in human red blood cells is 11.5-14.5%.[1] If anemia is observed, RDW test results are often used together with mean corpuscular volume (MCV) results to determine the possible causes of the anemia. It is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause. [url:http://purl.obolibrary.org/obo/SCDO_1000638] red blood cell distribution width RCDW RDW RDW-CV RDW-SD erythrocyte distribution width red cell distribution width red cell volume distribution width NCIT:C102267 PMID:33620437 MIO:00726 The determination of the amount of maximum concentration of thrombin generated during a thrombin generation test. [url:http://purl.obolibrary.org/obo/NCIT_C102267] endogenous thrombin potential peak height ETP peak height ETPPH peak thrombin concentration NCIT:C64604 MIO:00727 The determination of the ratio of eosinophils compared to leukocytes in a blood sample. The measurement may be expressed as a ratio or percentage. [url:http://purl.obolibrary.org/obo/NCIT_C64604] eosinophil to leukocyte ratio ELR EOS% EOSLE Eosinophils/Leukocytes eosinophil percentage MIO:00728 carbon dioxide combining power MIO:00729 CD45-/CXCR4+/FLK-1+ cells EFO:0009132 MIO:00730 Quantification of cholesterol efflux capacity, a measure of HDL functionality that quantifies the ability of an individual鈥檚 HDL to extract cholesterol from cholesterol-loaded macrophages. Efflux capacity is considered to be a predictor of atherosclerotic burden.[url:http://www.ebi.ac.uk/efo/EFO_0009132] cholesterol efflux capacity NCIT:C156516 MIO:00731 A calculation that indicates the likely presence of fatty liver disease, taking into account waist circumference, body mass index, triglyceride concentrations, and gamma-glutamyltransferase activity. (Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, Tiribelli C. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population.[url:http://purl.obolibrary.org/obo/NCIT_C156516] fatty liver index FATLVIDX FLI PMID:25890059 MIO:00732 The fractal dimension of the clot, df, which is a quantification of the clot structure. [PMID:25890059] fractal dimension MIO:00733 leuko-glycemic index MIO:00734 lipophilic index NCIT:C89729 MIO:00735 A mathematic formula used to estimate individual oxygen consumption, and thus energy expenditure, at rest and for various physical activities. [url:http://purl.obolibrary.org/obo/NCIT_C89729] metabolic equivalent of task MET PMID:25063538 MIO:00736 NEAC (excluding coffee) was measured using Italian food composition tables in terms of ferric reducing-antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC) and total radical-trapping antioxidant parameter (TRAP).[PMID:25063538] non-enzymatic antioxidant capacity NEAC NCIT:C13268 MIO:00737 A DNA packaging complex comprised of approximately 200 base pairs of DNA wound around a protein core, which is formed by an octomer of histones. The histone octomer includes two dimers of histones H2A and H2B that surround a tetramer consisting of two molecules of histone H3 and two molecules of histone H4. [url:http://purl.obolibrary.org/obo/NCIT_C13268] nucleosome PMID:31492095 MIO:00738 Oxygen consumption per kilogram of weight per minute at anaerobic threshold [PMID:31492095] oxygen consumption at ventilation threshold SNOMED:16206004 MIO:00739 oxygen delivery DICOM:126392 MIO:00740 The percent of the oxygen removed from the blood by tissue during its passage through the capillary network. For example, as measured by blood oxygenation level dependent (BOLD) MR. [DICOM:126392] oxygen extraction ratio OER oxygen extraction fraction CMO:0001324 MIO:00741 The amount of oxygen bound to hemoglobin in the blood expressed as a percentage of the maximal binding capacity.[url:http://purl.obolibrary.org/obo/CMO_0001324] oxygen saturation NCIT:C12954 MIO:00742 A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes. [http://purl.obolibrary.org/obo/NCIT_C12954] peripheral blood mononuclear cell PBMC peripheral blood mononuclear cells EFO:0009186 MIO:00743 Indicator of larger (> 12 fL) circulating platelets (percentage). [http://www.ebi.ac.uk/efo/EFO_0009186] platelet larger cell ratio P-LCR PMID:25890059 MIO:00744 the time taken to reach the Gel Point [PMID:25890059] real-time clot formation time PMID:19118249 MIO:00745 RPR, defined in the presence of P2Y12 reaction unit values above this cutoff. [PMID:19118249] residual platelet reactivity to adenosine diphosphate RPR to adenosine diphosphate MIO:00746 total antioxidant status NCIT:C74718 MIO:00747 The determination of the saturation of iron binding sites on serum transferrin proteins. [url:http://purl.obolibrary.org/obo/NCIT_C74718] total iron-binding capacity IBCT CMO:0002923 MIO:00748 The number of dissolved particles in a specified volume of plasma. [url:http://purl.obolibrary.org/obo/CMO_0002923] plasma osmolality PMID:18696021 MIO:00749 S1, the aerobic slope of the VCO2/VO2-curve, was calculated by linear regression analysis including all (y;x) pairs of the VCO2-O2 data points until reaching the anaerobic threshold. [PMID:18696021] S1 s1 NCIT:C38462 UMLS:C0030605 MIO:00750 A measurement of the length of time that it takes for clotting to occur when activating reagents are added to a plasma specimen. The test is partial due to the absence of tissue factor (Factor III) from the reaction mixture. [url:http://purl.obolibrary.org/obo/NCIT_C38462] activated partial thromboplastin time APTT NCIT:C74685 MIO:00751 A computed estimate of the unmeasured anions (those other than the chloride and bicarbonate anions) in a biological specimen. [url:http://purl.obolibrary.org/obo/NCIT_C74685] anion gap ANIONG NCIT:C76246 MIO:00752 A blood group indicating the presence on erythrocytes of only the A form of the H Antigen. [url:http://purl.obolibrary.org/obo/NCIT_C76246] blood group A A blood type blood type A NCIT:C76249 MIO:00753 A blood group indicating the absence on erythrocytes of both the A and B forms of the H Antigen. [url:http://purl.obolibrary.org/obo/NCIT_C76249] blood group O O blood group blood type O NCIT:C96592 UMLS:C3272886 MIO:00754 The determination of the amount of circulating endothelial cells present in the blood sample. [url:http://purl.obolibrary.org/obo/NCIT_C96592] circulating endothelial cell count CEC CEC count circulating endothelial cell circulating endothelial cell (CEC) count circulating endothelial cells counts of circulating endothelial cells OMIT:0028239 PMID:22082241 PMID:22476576 MIO:00755 Clot-lysis time (CLT) was assessed by measuring the changes in plasma turbidity during tissue-factor induced clot formation and subsequent lysis by exogenous t-PA. CLT was divided into tertiles based on the control group (T1-T3), with T2 as reference. clot-lysis time clot lysis time fibrin clot lysis time NCIT:C25747 MIO:00756 The determination of the clearance of endogenous creatinine, used for evaluating the glomerular filtration rate. A measurement of the volume of serum or plasma that would be cleared of creatinine by excretion of urine for a specified unit of time (e.g. one minute). [url:http://purl.obolibrary.org/obo/NCIT_C25747] creatinine clearance CCr CREATCLR CrCl creatinine clearance rate EFO:0005538 NCIT:C102266 PMID:33620437 UMLS:C3640656 MIO:00757 A measurement of the total concentration of thrombin generated in the presence of a substrate in a plasma or blood sample. [url:http://purl.obolibrary.org/obo/NCIT_C102266] endogenous thrombin potential ETP thrombin generation potential NCIT:C74611 UMLS:C1176468 MIO:00758 A quantitative measurement of the distance that red blood cells travel in 1 hour in a sample of unclotted blood.; The distance (e.g. millimeters) that red blood cells settle in unclotted blood over a specified unit of time (e.g. one hour).; The distance red blood cells travel in one hour in a sample of blood as they settle to the bottom of a test tube. The sedimentation rate is increased in inflammation, infection, cancer, rheumatic diseases, and diseases of the blood and bone marrow.; A quantitative measurement of the distance that red blood cells settle in one hour in a sample of unclotted blood. Used in the evaluation of systemic inflammation. [url:http://purl.obolibrary.org/obo/NCIT_C74611] erythrocyte sedimentation rate ESR biernacki reaction sed rate sedimentation rate GO:0042730 OMIT:0006553 MIO:00759 A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. [url:http://purl.obolibrary.org/obo/GO_0042730] fibrinolysis NCIT:C64796 UMLS:C0018935 MIO:00760 A measure of the volume of red blood cells expressed as a percentage of the total blood volume. Normal in males is 43-49%, in females 37-43%. [url:http://purl.obolibrary.org/obo/NCIT_C64796] hematocrit EVF HCT PCV erythrocyte volume fraction packed cell volume MIO:00761 The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system. [url:https://en.wikipedia.org/wiki/T_helper_cell] CD34+ cell CD4+ cells CD4-positive cell CD4-positive cells T helper cell T helper cells Th cell Th cells NCIT:C150814 MIO:00762 A determination of the amount of albumin being excreted in a biological specimen over a defined period of time. [http://purl.obolibrary.org/obo/NCIT_C150814] albumin excretion rate ALBEXR PMID:25890059 MIO:00763 the shear elastic modulus at the Gel Point (GP), G'GP, which is a measure of the strength of the incipient clot [PMID:25890059] blood clot strength NCIT:C126895 MIO:00764 A mouse monoclonal antibody that recognizes the soluble caspase-cleaved (cc) form of human keratin, type I cytoskeletal 18 (cytokeratin 18, K18, KRT18, CK18). Monoclonal antibody M30 binds to a neo-epitope (NE) exposed after caspase cleavage after the aspartic acid residue at position 396 of K18 (K18Asp396). This neo-epitope results from the proteolytic activity of caspase-3, -7 or -9, which are active during apoptosis. Thus, M30 can be used to indirectly identify caspase activation and to determine if the cell death in a sample is due to apoptosis rather than necrosis. [http://purl.obolibrary.org/obo/NCIT_C126895] monoclonal antibody M30 M30 monoclonal antibody M30 mouse anti-human K18Asp396 monoclonal antibody mouse anti-human K18Asp396 neo-epitope monoclonal antibody mouse anti-human K18Asp396-NE monoclonal antibody mouse anti-human caspase cleaved keratin 18 monoclonal antibody mouse anti-human ccK18 monoclonal antibody mouse monoclonal antibody M30 MIO:00765 A Muse cell (Multi-lineage differentiating stress enduring cell) is an endogenous non-cancerous pluripotent stem cell. They reside in the connective tissue of nearly every organ including the umbilical cord, bone marrow and peripheral blood.[url:https://en.wikipedia.org/wiki/Muse_cell] muse cell Multi-lineage differentiating stress enduring cell MIO:00766 NPAR was calculated as neutrophil percentage numerator divided by albumin in the admission blood samples. neutrophil percentage to albumin ratio NPAR PMID:8519007 MIO:00767 The oxygen tension at 50% saturation (P50), which expressed the hemoglobin affinity foroxygen,was calculated from a single measurement ofmixed venous pH, oxygen tension, and oxygen satura-tion according to Severinghaus'equation. [PMID:8519007] oxygen tension at 50% saturation P50 MIO:00768 systemic immune-inflammatory index MIO:00769 Maximum amplitude (MA): Maximum deviation of tracing to baseline.[url:https://en.wikipedia.org/wiki/Thromboelastography] thromboelastography maximum amplitude MIO:00770 total oxidative status TOS MP:0009348 MIO:00771 any anomaly in urinary pH, indicating alterations in urine acidity or alkalinity [ http://www.informatics.jax.org/accession/anna ] urinary pH SNOMED:250409002 MIO:00772 whole blood viscosity WBV whole blood viscosity level EFO:0008447 NCIT:C141271 MIO:00773 The determination of the ratio of neutrophils compared to lymphocytes present in a biological sample. The measurement may be expressed as a ratio or percentage. [url:http://purl.obolibrary.org/obo/NCIT_C141271] neutrophil to lymphocyte ratio N to L ratio NLR neutrophil to lymphocytes ratio neutrophil-to-lymphocyte ratio neutrophil/lymphocyte ratio neutrophils/lymphocytes NCIT:C123570 MIO:00774 The rate at which oxygen is absorbed and utilized by any given tissue in the body. [url:http://purl.obolibrary.org/obo/NCIT_C123570] oxygen consumption VO2 oxygen uptake NCIT:C40854 MIO:00775 Platelet Activation involves initiation of a set of stimulated platelet activities involved in aggregation of platelets and fibrin during blood coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C40854] platelet activation NCIT:C103427 OMIT:0011947 MIO:00776 The determination of the amount of the association of platelets to one another via adhesion molecules in a biological sample. [url:http://purl.obolibrary.org/obo/NCIT_C103427] platelet aggregation PLATAGGR platelet function EFO:0007984 NCIT:C81962 MIO:00777 Platelet distribution width (PDW) is an index reflecting heterogeneous platelet size. platelet distribution width PCDW PDW platelet component distribution width EFO:0004985 MIO:00778 A platelet reactivity measurement is the quantification of platelet reactivity e.g. by measuring platelet induced agglutination. High levels of platelet reactivity are reported to be associated with cardiovascular events. [url:http://www.ebi.ac.uk/efo/EFO_0004985] platelet reactivity PRU CMO:0001349 SNOMED:250314004 MIO:00779 The proportion of blood volume that is occupied by platelets, expressed as a percentage. [url:http://purl.obolibrary.org/obo/CMO_0001349] plateletcrit platecrit platelet haematocrit platelet hematocrit EFO:0008446 PMID:33738014 MIO:00780 The ratio of platelet count to lymphocyte count, quantified in a blood sample. Both neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio have been proposed as biomarkers for the diagnosis or prognostic prediction of disease. [url:http://www.ebi.ac.uk/efo/EFO_0008446] platelet-to-lymphocyte ratio PLR platelet:lymphocyte ratio NCIT:C174013 MIO:00781 The time interval from blood supply separation or reduction to further processing, preservation, or blood supply reconnection for a tissue, organ, or body part. [url:http://purl.obolibrary.org/obo/NCIT_C174013] ischemia time SO-FMC SO-FMC time SO-to-FMC time ischaemic time ischemic time symptom onset to first medical contact time time from onset of symptom to treatment time from onset of symptoms to treatment time from onset to reperfusion time from symptom debut to intervention time from symptom onset to infarct-related arteries reflow time from symptom onset to reperfusion time to coronary reperfusion time to reperfusion time to treatment total ischemic time EUPATH:0000745 MIO:00782 A time measurement datum of duration of an individual acquires, develops, or first experiences a condition or symptoms of a disease or disorder. [url:http://purl.obolibrary.org/obo/EUPATH_0000745] time to onset time of onset of symptoms time of symptom onset NCIT:C180918 MIO:00783 A vehicle specially equipped for transporting the injured or sick. [url:http://purl.obolibrary.org/obo/NCIT_C180918] ambulance ambulance MIO:00784 Failure of angiography. angiographic failure failure of angiography MIO:00785 arrived from cardiac rehabilitation center PMID:30354373 MIO:00786 CCL cancellations (CCLX) are defined as any CCL-staff activation for possible patients with STEMI who ultimately do not require emergent coronary angiography (EA). CCLX can cause patient confusion, frustration, and perhaps even distrust in the medical providers.[PMID:30354373] cardiac catheterization laboratory cancellations CCL cancellations CCLX EFO:0007653 MIO:00787 the characteristics of a person's cardiovascular health based on a number of factors including cholesterol levels in the absence of treatment, blood pressure and diabetes status [url:http://www.ebi.ac.uk/efo/EFO_0007653] clinical ideal cardiovascular health MIO:00788 discharge against medical advice MIO:00789 duration of intensive care unit stay duration of cardiac intensive care unit stay PMID:7572573 MIO:00790 the ability to suppress ambient ventricular ectopy on the lowest dose of the first randomly chosen CAST drug [PMID:7572573] ease of suppression MIO:00791 The cost for hospitalization. hospitalization cost MIO:00792 return to operating room MIO:00793 severe preoperative condition MIO:00794 surgical priority MIO:00795 thermodilution-derived temperature recovery time MIO:00796 time from onset to ventricular septal rupture MIO:00797 time from symptom-onset to wire MIO:00798 transtelephonic electrocardiogram-based triage NCIT:C100085 MIO:00799 The passage of a catheter into the aortic root or other great vessel for the purpose of angiography of the native coronary arteries or bypass grafts supplying native coronary arteries.[url:http://purl.obolibrary.org/obo/NCIT_C100085] undergoing coronary angiography PMID:32065586 MIO:00800 The Academic Research Consortium for High Bleeding Risk (ARC-HBR) defined consensus-based criteria for patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI). [PMID:32065586] ARC-HBR criteria ARC-HBR Academic Research Consortium for High Bleeding Risk PMID:24393257/ MIO:00801 D2B time was defined as hospital arrival to primary PCI. [url:https://pubmed.ncbi.nlm.nih.gov/24393257/] door-to-balloon time D2B time PMID:25889701 MIO:00802 door-to-extracorporeal membrane oxygenation time door-to-ECMO time SCDO:0000739 MIO:00803 Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency. [url:http://purl.obolibrary.org/obo/SCDO_0000739] medication adherence NCIT:C117536 MIO:00804 The interval between two procedure reference time points. [url:http://purl.obolibrary.org/obo/NCIT_C117536] procedure elapsed time PRELTM duration of surgery procedure time EFO:0004778 MIO:00805 The process of questioning an individual, usually by means of a survey to determine general health. [url:http://www.ebi.ac.uk/efo/EFO_0004778] self rated health SRH self-rated health PMID:26728478 MIO:00806 From chest pain onset to diagnosis time to hospital time from the onset of symptoms to hospital NCIT:C171454 MIO:00807 The subject or patient has been admitted as an inpatient to a intensive care unit. [url:http://purl.obolibrary.org/obo/NCIT_C171454] intensive care unit stay icu stay intensive care unit stay MIO:00808 emergency hospital admission MIO:00809 European Society of Cardiology Acute Cardiovascular Care Association quality MIO:00810 guideline adherence PMID:28070360 MIO:00811 Draw a picture of what you think your heart looked like before your heart attack and another picture of what you think has happened to your heart after your heart attack.[PMID:28070360] heart drawing MIO:00812 hospital process interval MIO:00813 hour of emergency medical service activation MIO:00814 non-home discharge MIO:00815 off-hours admissions for primary percutaneous coronary intervention PMID:28603592 MIO:00816 Polymer jacketed guidewires (PGW) have the advantage of maximum lubricity which allows them to be easily withdrawn from a jailed position. [PMID:28603592] polymer jacketed guidewire PGW MIO:00817 postoperative stay MIO:00818 programmed ventricular stimulation MIO:00819 radial access MIO:00820 referral to endoscopy service GO:0036273 MIO:00821 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its [url:http://purl.obolibrary.org/obo/GO_0036273] response to statin MIO:00822 surgery at low-volume centers MIO:00823 usual source of care MIO:00824 volume of contrast agent NCIT:C34943 MIO:00825 A pregnancy induced hypertensive state that occurs after 20 weeks of gestation characterized by an increase in blood pressure, along with body swelling and proteinuria. [url:http://purl.obolibrary.org/obo/NCIT_C34943] toxemia of pregnancy toxemia of pregnancy NCIT:C3671 MIO:00826 Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity. [url:http://purl.obolibrary.org/obo/NCIT_C3671] injury injury trauma traumatic injury wound HP:0004323 MIO:00827 An abnormal increase or decrease of weight or an abnormal distribution of mass in the body. [url:http://purl.obolibrary.org/obo/HP_0004323] abnormality of body weight HP:0001928 MIO:00828 An abnormality of the process of blood coagulation. That is, altered ability or inability of the blood to clot. [ HPO : probinson ] [url:http://purl.obolibrary.org/obo/HP_0001928] abnormality of coagulation abnormal blood coagulation studies cbnormal blood coagulation studies coagulation abnormalities haemorrhagic disorders HP:0001939 MIO:00829 abnormality of metabolism/homeostasis laboratory abnormality metabolism abnormality HP:0001626 MIO:00830 The cardiovascular system consists of the heart, vasculature, and the lymphatic system.[url:http://purl.obolibrary.org/obo/HP_0001626] Any abnormality of the cardiovascular system. The cardiovascular system consists of the heart, vasculature, and the lymphatic system. [url:http://purl.obolibrary.org/obo/HP_0001626] abnormality of the cardiovascular system abnormality of the cardiovascular system cardiovascular abnormality HP:0025031 MIO:00831 Any anomaly of the digestive system, a collection of organs that is made up of the gastrointestinal tract and the liver, pancreas, and gallbladder. The gastrointestinal tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus, including the mouth, esophagus, stomach, small intestine, large intestine and anus.[url:http://purl.obolibrary.org/obo/HP_0025031] abnormality of the digestive system HP:0000818 MIO:00832 An abnormality of the endocrine system. [ HPO : probinson ] [url:http://purl.obolibrary.org/obo/HP_0000818] abnormality of the endocrine system HP:0002715 MIO:00833 An abnormality of the immune system. [ HPO : probinson ] [url:http://purl.obolibrary.org/obo/HP_0002715] abnormality of the immune system abnormality of the immune system immunological abnormality HP:0000707 MIO:00834 An abnormality of the nervous system. [ HPO : probinson ] [url:http://purl.obolibrary.org/obo/HP_0000707] abnormality of the nervous system abnormality of the nervous system neurologic abnormalities neurological abnormality HP:0002086 MIO:00835 An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles. [ HPO : probinson ] [url:http://purl.obolibrary.org/obo/HP_0002086] abnormality of the respiratory system respiratory abnormality DOID:17 EFO:0009676 NCIT:C107377 MIO:00836 A disease of anatomical entity that occurs in the muscular and/or skeletal system. [url:http://purl.obolibrary.org/obo/DOID_17] musculoskeletal system disease disease of musculoskeletal system disease or disorder of musculoskeletal system disorder of musculoskeletal system musculoskeletal disease musculoskeletal disorder musculoskeletal system disease or disorder musculoskeletal system disorder HP:0012531 MSH:D010146 PMID:11182180 SNOMED:22253000 UMLS:C0030193 MIO:00837 An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. [url:http://purl.obolibrary.org/obo/HP_0012531] pain DOID:1876 NCIT:C3347 MIO:00838 Disturbances in sexual desire or performance. [url:http://purl.obolibrary.org/obo/NCIT_C3347] sexual dysfunction sexual dysfunction EFO:0002461 MIO:00839 A disease involving the skeletal system. [url:http://www.ebi.ac.uk/efo/EFO_0002461] skeletal system disease disease of skeletal system disease or disorder of skeletal system disorder of skeletal system skeletal system disease or disorder MONDO:0002254 NCIT:C28193 MIO:00840 A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition. [url:http://purl.obolibrary.org/obo/MONDO_0002254] syndromic disease syndrome MIO:00841 emergency medical services provider-assessed cardiac symptoms PMID:28599258 MIO:00842 Clinical manifestations of extracoronary artery diseases (ECADs), such as claudication or cerebrovascular disease, are linked to CAD and are associated with worse prognosis in patients with manifest CAD. [PMID:28599258] extracoronary artery disease SNOMED:297994000 MIO:00843 Hypopigmented hair that appears silver-gray.[url:http://purl.obolibrary.org/obo/HP_0002218] gray hair grey hair silver-gray hair silver-gray hair color silver-gray hair colour silvery-gray hair MIO:00844 low vitality MP:0013139 MIO:00845 in terminal decline and approaching death; lacking vitality or vigor and becoming unresponsive [url:http://purl.obolibrary.org/obo/MP_0013139] moribund MIO:00846 non-aneurysm HP:0031413 MIO:00847 An abnormal reduction in telomere length. Telomeres are non-coding, repetitive sequences of DNA at the ends of the chromosomes of eukaryotic cells which become shorter as cells divide, and when telomere attrition reaches its limit, cell proliferation arrest, senescence, and apoptosis can occur. [url:http://purl.obolibrary.org/obo/HP_0031413] short telomere length MIO:00848 ulcer stigmata MIO:00849 In an declined condition by physical activity. worsened by physical activity MIO:00850 physically ill PMID:29083808 SNOMED:87872006 MIO:00851 Pattern hair loss is hair loss that primarily affects the top and front of the scalp. In male-pattern hair loss (MPHL), the hair loss typically presents itself as either a receding front hairline, loss of hair on the crown (vertex) of the scalp, or a combination of both. Female-pattern hair loss (FPHL) typically presents as a diffuse thinning of the hair across the entire scalp. [url:https://en.wikipedia.org/wiki/Pattern_hair_loss] male pattern baldness androgenetic alopecia androgenic alopecia common baldness female pattern baldness hereditary alopecia male pattern alopecia male-pattern hair loss pattern baldness pattern hair loss vertex baldness MP:0003674 NCIT:C17741 MIO:00852 condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma [url:http://purl.obolibrary.org/obo/MP_0003674] oxidative stress OSI oxidative stress index SIO:010038 MIO:00853 A drug is a chemical substance that contains one or more active ingredients that regulate one or more biological processes. [url:http://semanticscience.org/resource/SIO_010038] drug agent MIO:00854 Job demands: physical, psychological, social, or organizational aspects of the job, that require sustained physical and/or psychological effort or skills. Therefore, they are associated with certain physiological and/or psychological costs. Examples are work pressure and emotional demands. [url:https://en.wikipedia.org/wiki/Job_demands-resources_model] high job demand NCIT:C17173 MIO:00855 The branch of medical science that treats disease or injury by operative procedures. [url:http://purl.obolibrary.org/obo/NCIT_C17173] surgery MIO:00856 In meteorology, precipitation is any product of the condensation of atmospheric water vapor that falls under gravitational pull from clouds. The main forms of precipitation include drizzling, rain, sleet, snow, ice pellets, graupel and hail. [url:https://en.wikipedia.org/wiki/Precipitation] precipitation NCIT:C94729 MIO:00857 Any of the four periods into which the year is divided by the equinoxes and solstices. [url:http://purl.obolibrary.org/obo/NCIT_C94729] season XCO:0000011 MIO:00858 The degree of heat or cold of the air surrounding an organism. [url:http://purl.obolibrary.org/obo/XCO_0000011] temperature air temperature temperature of air PATO:0015009 MIO:00859 A quality inhering in air by virtue of the partial pressure exerted by the bearer's water vapour content. [url:http://purl.obolibrary.org/obo/PATO_0015009] humidity ECTO:8000036 MIO:00860 A exposure event involving the interaction of an exposure receptor to air pollution. [url:http://purl.obolibrary.org/obo/ECTO_8000036] exposure to air pollution air pollution air pollution exposure SNOMED:102412001 MIO:00861 Noise pollution, also known as environmental noise or sound pollution, is the propagation of noise with ranging impacts on the activity of human or animal life, most of them harmful to a degree. The source of outdoor noise worldwide is mainly caused by machines, transport, and propagation systems. [url:https://en.wikipedia.org/wiki/Noise_pollution] noise pollution exposed to noise exposure to noise CHEBI:77853 MIO:00862 Any environmental contaminant that is resistant to environmental degradation through photolytic, biological or chemical processes. Such substances can have significant impact on health and the environment, as they persist in the environment, bioaccumulate in animal tissue and so biomagnify in food chains. [url:http://purl.obolibrary.org/obo/CHEBI_77853] exposure to persistent organic pollutant POPs persistent organic pollutant persistent organic pollutants ECTO:9001625 MIO:00863 An exposure to polychlorinated dibenzodioxine. [url:http://purl.obolibrary.org/obo/ECTO_9001625] exposure to polychlorinated dibenzodioxine GSSO:011080 SCDO:0001204 MIO:00864 A human settlement with a high population density and infrastructure of built environment. Urban areas are created through urbanization and are categorized by urban morphology as cities, towns, conurbations or suburbs. In urbanism, the term contrasts to rural areas such as villages and hamlets; in urban sociology or urban anthropology it contrasts with natural environment. [url:http://purl.obolibrary.org/obo/GSSO_011080] urban area urban urban areas urban environment urban location urban setting PMID:20411218 MIO:00865 Early mitral inflow peak velocity (E) divided by mitral flow propagation velocity (FPV) has been documented to predict left ventricular (LV) filling pressure in patients with various degrees of LV dysfunction. [PMID:20411218] ratio of peak E wave velocity to flow propagation velocity E/FPV E/flow propagation velocity SNOMED:265484009 MIO:00866 left ventriculography LVG left ventriculogram PMID:7722131 MIO:00867 Circumferential strain (CS) of the LV apex was calculated using the same apical short-axis cycle that was used for the calculation of the apical rotation. Apical circumferential strain (CS) was defined as the average CS of all 6 segments in a particular short-axis view.[PMID:25039026] apical circumferential strain PMID:28673476 MIO:00868 average circumferential strain of segments using wall motion score index (WMSI) scores >/=2 [PMID:28673476] circumferential strain-wall motion score index DICOM:130677 MIO:00869 Lagrangian strain tangential to the reference contour, perpendicular to the longitudinal strain, with positive values in the counterclockwise direction when viewed from the apex.[url:http://dicom.nema.org/resources/ontology/DCM/130677] endocardial circumferential strain DICOM:130677 MIO:00870 Lagrangian strain tangential to the reference contour, perpendicular to the longitudinal strain, with positive values in the counterclockwise direction when viewed from the apex.[DICOM:130677] epicardial circumferential strain PMID:29450717 MIO:00871 Global circumferential strain was recorded as the average of all segmental peak circumferential strains. [url:https://pubmed.ncbi.nlm.nih.gov/35295253/] global circumferential strain GCS LVGCS global CS NCIT:C99941 MIO:00872 The right coronary artery supplies the posterior descending artery (PDA) and the circumflex supplies the posterolateral artery (PLA). Thus, there is approximately equal contribution to the inferior surface of the left ventricle from both the left circumflex and right coronary arteries. (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C99941] co-dominant artery co-dominant NCIT:C99942 MIO:00873 The posterior descending artery (PDA) and posterolateral artery (PLA) arises from the right coronary artery. (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C99942] coronary artery right dominance right coronary dominance right dominance NCIT:C99971 MIO:00874 The posterior descending artery (PDA) and posterolateral artery (PLA) arises from the left circumflex artery. (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C99971] left cardiac artery dominance left dominance PMID:11502048 MIO:00875 Diastolic deceleration half time was determined as the time interval between peak diastolic velocity and 1/2 of it. [url:https://pubmed.ncbi.nlm.nih.gov/11502048/] diastolic deceleration half time DHT PMID:28303647 MIO:00876 Systolic blood pressure (SBP)/left ventricular end-diastolic pressure (SBP/LVEDP) ratio was calculated as SBP divided by LVEDP.[PMID:28303647] systolic blood pressure to left ventricular end-diastolic pressure ratio PMID:12778023 MIO:00877 Left ventricular end-diastolic volume (LVEDV) was indexed to body surface to get the LVEDV index. [PMID:12778023] left ventricular end-diastolic volume index EFO:0010556 MIO:00878 Quantification of the ratio of left ventricular mass to end-diastolic volume. Elevated left ventricular mass/end-diastolic volume ratio has been associated with higher evidence of myocardial fibrosis and dysfunction in hypertensive patients.[EFO:0010556] left ventricular mass to end-diastolic volume ratio ratio of left ventricular mass to end-diastolic volume PMID:12778023 MIO:00879 Left ventricular end-systolic volume (LVSDV) was indexed to body surface to get the LVESV index. [PMID:12778023] left ventricular end-systolic volume index LVSDV NCIT:C142243 MIO:00880 The left ventricular mass divided by the subject's body surface area. [url:http://purl.obolibrary.org/obo/NCIT_C142243] left ventricular mass index LVMASIDX LVMI DICOM:130670 MIO:00881 Lagrangian strain parallel to the reference contour (i.e. in the longitudinal direction) calculated as: SL(t)=(L(t) -L0)/L0, where L(t) is the length at a given point t in time and L0 is the reference length at the reference time t0.Strain values are negative with shortening. Due to the common convention of using end-diastole as the t0 reference time, echocardiography strain values are typically negative. [url:http://dicom.nema.org/resources/ontology/DCM/130670] endocardial longitudinal strain DICOM:130670 MIO:00882 Lagrangian strain parallel to the reference contour (i.e. in the longitudinal direction) calculated as: SL(t)=(L(t) -L0)/L0, where L(t) is the length at a given point t in time and L0 is the reference length at the reference time t0.Strain values are negative with shortening. Due to the common convention of using end-diastole as the t0 reference time, echocardiography strain values are typically negative. [DICOM:130670] epicardial longitudinal strain MIO:00883 left atrial longitudinal strain NCIT:C172266 PMID:3229696 MIO:00884 A parameter that is used to assess global left ventricular systolic function by quantifying the percent change in myocardial length from a relaxed to a contractile state using tissue tracking imaging techniques. [url:http://purl.obolibrary.org/obo/NCIT_C172266] global longitudinal strain GLS LVGLS global LS left ventricular global longitudinal strain DICOM:130671 MIO:00885 Peak value of longitudinal Lagrangian strain during an identified interval, such as systole or a full cardiac cycle. [url:http://dicom.nema.org/resources/ontology/DCM/130671] peak longitudinal strain peak longitudinal lagrangian strain MIO:00886 Regional longitudinal strain was defined as the highest longitudinal strain values in four adjacent left ventricular segments and termed 4AS. [url:https://pubmed.ncbi.nlm.nih.gov/35290613/] regional longitudinal strain RLS regional LS PMID:9639373 MIO:00887 no myocardial blush or contrast density [url:https://pubmed.ncbi.nlm.nih.gov/9639373/] myocardial blush grade-0 MBG 0 PMID:9639373 MIO:00888 minimal myocardial blush or contrast density [url:https://pubmed.ncbi.nlm.nih.gov/9639373/] myocardial blush grade-1 MBG 1 PMID:9639373 MIO:00889 moderate myocardial blush or contrast density but less than that obtained during angiography of a contralateral or ipsilateral non–infarct-related coronary artery [url:https://pubmed.ncbi.nlm.nih.gov/9639373/] myocardial blush grade-2 MBG 2 PMID:9639373 MIO:00890 normal myocardial blush or contrast density, comparable with that obtained during angiography of a contralateral or ipsilateral non–infarct-related coronary artery [url:https://pubmed.ncbi.nlm.nih.gov/9639373/] myocardial blush grade-3 MBG 3 PMID:32296969 MIO:00891 Global radial strain was recorded as the average of all segmental peak radial strain. [url:https://pubmed.ncbi.nlm.nih.gov/32296969/] global radial strain GRS global RS PMID:33057322 MIO:00892 The 2D AS was measured from the apical 4-, 2-, and 3-chamber views. Measurements were obtained for each segment in a modified 17-segment model. [PMID:33057322] apical strain AS MIO:00893 strain rate during isovolumic relaxation NCIT:C100040 MIO:00894 No perfusion: No antegrade flow beyond the point of occlusion. [url:http://purl.obolibrary.org/obo/NCIT_C100040] thrombolysis in myocardial infarction flow-0 TIMI flow-0 TIMI grade 0 thrombolysis in myocardial infarction flow - 0 NCIT:C100041 MIO:00895 Penetration without perfusion: The contrast material passes beyond the area of obstruction, but fails to opacify the entire coronary bed distal to the obstruction for the duration of the cine run. [url:http://purl.obolibrary.org/obo/NCIT_C100041] thrombolysis in myocardial infarction flow-1 TIMI flow-1 TIMI grade 1 thrombolysis in myocardial infarction flow - 1 NCIT:C100042 MIO:00896 Partial reperfusion: The contrast material passes across the obstruction and opacifies the entire coronary bed distal to the obstruction. However, the rate of entry of contrast into the vessel distal to the obstruction and/or its rate of clearance from the distal bed are perceptibly slower than its entry into and/or clearance from comparable areas not perfused by the culprit vessel (e.g., the opposite coronary artery or coronary bed proximal to the obstruction). [url:http://purl.obolibrary.org/obo/NCIT_C100042] thrombolysis in myocardial infarction flow-2 TIMI flow-2 TIMI grade 2 thrombolysis in myocardial infarction flow - 2 NCIT:C100043 MIO:00897 Complete perfusion: Antegrade flow into the bed distal to the obstruction occurs as promptly as into the bed proximal to the obstruction and clearance of contrast material from the involved bed is as rapid as from an uninvolved bed in the same vessel or the opposite artery. [url:http://purl.obolibrary.org/obo/NCIT_C100043] thrombolysis in myocardial infarction flow-3 TIMI flow-3 TIMI grade 3 thrombolysis in myocardial infarction flow - 3 NCIT:C119583 MIO:00898 Possible thrombus present - angiography demonstrates characteristics such as reduced contrast density, haziness, irregular lesion contour or a smooth convex 'meniscus' at the site of total occlusion suggestive but not diagnostic of thrombus. [url:http://purl.obolibrary.org/obo/NCIT_C119583] TIMI coronary thrombus grade 1 TIMI thrombus grade 1 NCIT:C119584 MIO:00899 Small size definite thrombus, with greatest dimensions less than or equal to 1/2 vessel diameter. [url:http://purl.obolibrary.org/obo/NCIT_C119584] TIMI coronary thrombus grade 2 TIMI thrombus grade 2 NCIT:C119585 MIO:00900 Moderate size definite thrombus, with greatest linear dimension greater than 1/2 but less than 2 vessel diameters. [url:http://purl.obolibrary.org/obo/NCIT_C119585] TIMI coronary thrombus grade 3 TIMI thrombus grade 3 NCIT:C119586 MIO:00901 Large size definite thrombus, with the largest dimension greater than or equal to 2 vessel diameters. [url:http://purl.obolibrary.org/obo/NCIT_C119586] TIMI coronary thrombus grade 4 TIMI thrombus grade 4 NCIT:C119587 MIO:00902 Total vessel occlusion. [url:http://purl.obolibrary.org/obo/NCIT_C119587] TIMI coronary thrombus grade 5 TIMI thrombus grade 5 NBO:0001884 MIO:00903 Behavior related to the intake of addictive substances. [url:http://purl.obolibrary.org/obo/NBO_0001884] consumption of an addictive substance NCIT:C169077 SNOMED:226379006 MIO:00904 A record of the food and liquid consumed by an individual. [url:http://purl.obolibrary.org/obo/NCIT_C169077] dietary intake dietary intake DOID:302 MESH:D019966 NCIT:C16522 MIO:00905 A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. [url:http://purl.obolibrary.org/obo/DOID_302] substance abuse MIO:00906 Tar is the name for the resinous, partially combusted particulate matter made by the burning of tobacco and other plant material in the act of smoking. Tar is toxic and damages the smoker's lungs over time through various biochemical and mechanical processes. [url:https://en.wikipedia.org/wiki/Tar_(tobacco_residue)] tar intake intake of tar tar NCIT:C15447 PMID:30563358 MIO:00907 In numerous observational studies, both case–control and cohort as well as their meta-analyses, men and women who adopt a healthy diet experience significantly decreased risks of a first MI and stroke.[url:https://pubmed.ncbi.nlm.nih.gov/30563358/] Any alteration or treatment in an individual's diet with a planned goal, usually designed to improve the individual's overall health. [url:http://purl.obolibrary.org/obo/NCIT_C15447] dietary modification dietary intervention dietary interventions dietary modifications nutrition intervention nutrition interventions SNOMED:1171000175109 MIO:00908 increased physical activity NCIT:C17427 PMID:30563358 UMLS:C0085134 MIO:00909 The amount currently smoked is a major risk factor for MI and stroke. Thus, a 4 pack per day smoker for 10 years has a far higher risk of MI or stroke than a 1 pack per day smoker for 40 years although each has experienced 40 pack-years of smoking. Further, in general, current smokers have about twice the risk of MI or stroke than non-smokers, including the elderly population.[url:https://pubmed.ncbi.nlm.nih.gov/30563358/] Discontinuation of the habit of smoking. [url:http://purl.obolibrary.org/obo/NCIT_C17427] smoking cessation cessation of cigarette smoking quit smoking quitting smoking stopping smoking SNOMED:160593006 MIO:00910 moderate alcohol consumption alcohol intake in moderation alcohol intake within recommended sensible limits avoidance of heavy alcohol consumption light drinker light drinkers light-to-moderate alcohol consumption low to moderate consumption moderate alcohol intake NCIT:C16567 MIO:00911 Activity that requires physical or mental exertion, especially when performed to develop or maintain fitness. [url:http://purl.obolibrary.org/obo/NCIT_C16567] exercise exercise training exercise-training SNOMED:4751000 MIO:00912 LTPA was defined as 0, 1-149 or ≥150 min/week of moderate-to-vigorous activity. [url:https://pubmed.ncbi.nlm.nih.gov/33737330/] leisure time physical activity LTPA leisure activities leisure physical activity leisure-time physical activity PMID:25599524 MIO:00913 OPA was measured using two questions: (1) ‘How often does your job involve repeated lifting, pushing, pulling or bending?’ (occupational exertion (OE)) and (2) ‘How often does your job involve standing or walking around?’ (occupational standing and walking (OSW)). Participants responded to a 5- item Likert scale (0=never, 1=seldom, 2=sometimes, 3=often, 4=always). Total occupational activity (TOA) was calculated by summing these two scores and then categorising as: 0=never, 1 or 2=seldom, 3 or 4=sometimes, 5 or 6=often, 7 or 8=always. [url:https://pubmed.ncbi.nlm.nih.gov/33737330/] occupational physical activity OPA work related activity working activity NCIT:C85399 MIO:00914 An active diversion requiring physical exertion and competition. [url:http://purl.obolibrary.org/obo/NCIT_C85399] sport sports NCIT:C53291 MIO:00915 Those physical activities which are required for our daily existence. These include personal maintenance activities and activities for maintenance of our living space, as well as activities related to independent living. The tasks of everyday life. These activities include eating, dressing, getting into or out of a bed or chair, taking a bath or shower, and using the toilet. Instrumental activities of daily living are activities related to independent living and include preparing meals, managing money, shopping, doing housework, and using a telephone. [url:http://purl.obolibrary.org/obo/NCIT_C53291] activity of daily living ADL activities of daily living activity of daily living daily activity household activity NCIT:C85401 MIO:00916 Riding a bicycle for transportation or recreation. [url:http://purl.obolibrary.org/obo/NCIT_C85401] bicycling bike cycling SNOMED:724237005 VT:0010731 MIO:00917 Any measurable or observable characteristic related to the pattern of movement of the limbs, characterized by elements of progression, stability, speed and length over the ground. [url:http://purl.obolibrary.org/obo/VT_0010731] gait speed MIO:00918 gardening MIO:00919 physical activity in the case period SCDO:0001029 MIO:00920 Usual level of physical activity that is less than 30 minutes of moderate-intensity activity on most days of the week. [url:http://purl.obolibrary.org/obo/SCDO_0001029] sedentary lifestyle sedentary PMID:17236983 MIO:00921 Time spent on activities exceeding 6 METS was used to calculate usual heavy physical exertion. [url:https://pubmed.ncbi.nlm.nih.gov/17236983/] strenuous physical activity heavy physical activity heavy physical exertion MIO:00922 The act of traveling by foot. [url:http://purl.obolibrary.org/obo/NCIT_C73554] walking ambulation by foot on foot walk EFO:0005271 NBO:0000160 MIO:00923 duration of sleep, measured either via a self-reporting questionnaire, interview or through obversation in a sleep lab [url:http://www.ebi.ac.uk/efo/EFO_0005271] sleep duration duration of sleep MIO:00924 age under 70 years age 69 years or younger age </=69 years age <70 years age below 70 years age ≤69 years aged </=69 years aged <70 years aged under 70 years under 70 years of age under 70 years old PATO:0000309 MIO:00925 An age which is relatively low. [ PATOC:GVG ] [url:http://purl.obolibrary.org/obo/PATO_0000309] young EFO:0004704 NCIT:C106497 MIO:00926 The age at which permanent cessation of menses occurs. [url:http://purl.obolibrary.org/obo/NCIT_C106497] age at menopause MENOAGE menopause age NCIT:C25298 MIO:00927 The maximum pressure exerted into the systemic arterial circulation during the contraction of the left ventricle of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C25298] systolic blood pressure SBP SYSBP systolic BP systolic pressure NCIT:C120941 MIO:00928 The blood pressure in the pulmonary artery during ventricular relaxation (diastole). [url:http://purl.obolibrary.org/obo/NCIT_C120941] pulmonary artery diastolic pressure PULDIABP pulmonary arterial diastolic pressure pulmonary diastolic pressure MIO:00929 Right atrial pressure (RAP) is the blood pressure in the right atrium of the heart. RAP reflects the amount of blood returning to the heart and the ability of the heart to pump the blood into the arterial system. [url:https://en.wikipedia.org/wiki/Right_atrial_pressure] right atrial pressure RAP NCIT:C25299 UMLS:C0428883 MIO:00930 The minimum pressure exerted into the systemic arterial circulation during cardiac ventricular relaxation and filling. [url:http://purl.obolibrary.org/obo/NCIT_C25299] diastolic blood pressure DBP DIABP Diastolic Pressure NCIT:C49679 MIO:00931 The mean pressure of the blood within the arterial circulation. The arterial pressure may be directly measured by insertion of an intra-arterial catheter connected to a transducer. The mean arterial pressure (MAP) can be calculated by subsequent analysis of the waveform. MAP can be approximated without an invasive procedure using the following formula: diastolic pressure plus 1/3 of the pulse pressure, where pulse pressure is systolic pressure - diastolic pressure. [url:http://purl.obolibrary.org/obo/NCIT_C49679] mean arterial pressure CMO:0000292 NCIT:C100945 MIO:00932 The difference between systolic and diastolic blood pressures, i.e. the difference between the maximal arterial pressure and minimal arterial pressure during the cardiac cycle. [url:http://purl.obolibrary.org/obo/CMO_0000292] pulse pressure PULSEPR NCIT:C119245 UMLS:C0428776 MIO:00933 The measure of an individual's cardiac output as divided by their body surface area (CI= CO/BSA). This calculation is a useful function to determine an individual's cardiac performance in relation to their body size, providing an overview of global cardiovascular function. [url:http://purl.obolibrary.org/obo/NCIT_C119245] cardiac index CARDIDX ECG:000001064 MIO:00934 A specifically dependent continuant that is computed based upon an ECG Wave. [url:http://www.cvrgrid.org/files/ECGOntologyv1.owl#ECG_000001064] electrocardiographic score ECG score ECG:000000309 MIO:00935 The junction between the QRS complex and the ST segment. [url:http://www.cvrgrid.org/files/ECGOntologyv1.owl#ECG_000000309] J point NCIT:C41327 UMLS:C0429084 MIO:00936 An electrocardiographic finding of the current of atrial contraction when they are depolarized. The initial portion of the P wave is largely a reflection of right atrial depolarization and the terminal portion reflects depolarization of the left atrium. [url:http://purl.obolibrary.org/obo/NCIT_C41327] P wave P-wave MIO:00937 Positive T wave was defined as T‐wave amplitude >0 mV. positive T wave T wave positivity positive T waves SNOMED:24607002 MIO:00938 Q wave Q wave feature Q-wave morphology EFO:0005054 NCIT:C41329 UMLS:C0429097 MIO:00939 A QRS complex is a combination of the three electrocardiographical measurements of the Q, R and S waves in the heart's electrical cycle. It corresponds to the depolarization of the right and left ventricles of the human heart. The QRS complex can be further classified into a set of parameters, including QRS duration, QRS amplitude and ventricular activation time (VAT). [url:http://www.ebi.ac.uk/efo/EFO_0005054] QRS complex NCIT:C83501 MIO:00940 The time interval between the start of the Q wave and the end of the T wave in the cardiac cycle. [url:http://purl.obolibrary.org/obo/NCIT_C83501] QT interval SNOMED:81184002 MIO:00941 R wave SNOMED:3030002 MIO:00942 In electrocardiography, the ST segment connects the QRS complex and the T wave and has a duration of 0.005 to 0.150 sec (5 to 150 ms). [url:https://en.wikipedia.org/wiki/ST_segment] ST segment PMID:21875755 MIO:00943 Numerous studies have reported that the degree of resolution of ST-segment resolution (STR) following reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI) represents a predictor of the preserved left ventricular function, malignant ventricular arrhythmia or sudden cardiac death, and long-term survival.[url:https://pubmed.ncbi.nlm.nih.gov/30412109/] ST segment resolution (STR) after reperfusion therapy was defined as 70% ST recovery, complete ST resolution; 30% but 70% ST recovery, partial ST resolution; or 30% ST recovery, no ST resolution. ST segment resolution ST resolution ST segment recovery ST-recovery ST-segment resolution STR STSR MIO:00944 In electrocardiography, the T wave represents the repolarization of the ventricles. The interval from the beginning of the QRS complex to the apex of the T wave is referred to as the absolute refractory period. The last half of the T wave is referred to as the relative refractory period or vulnerable period. The T wave contains more information than the QT interval. The T wave can be described by its symmetry, skewness, slope of ascending and descending limbs, amplitude and subintervals like the Tpeak–Tend interval. [url:https://en.wikipedia.org/wiki/T_wave] T wave T wave morphology T-wave NCIT:C71089 UMLS:C0232333 MIO:00945 U waves represent prolonged repolarisation of myocardial M cells. Under normal conditions the M cells are electrically coupled to adjacent cell layers. However, in conditions that produce electrical uncoupling, these M cells have significant effects on repolarisation producing prolonged rounded ST-T waves or U waves. The finding of U wave inversion on an ECG at rest or baseline is a non-specific finding. It is significant when observed post exercise, being originally described in early 1940s. Subsequent studies in the late 1970s, demonstrated a significant correlation of U wave inversion with either left main or LAD disease.[url:http://purl.obolibrary.org/obo/HP_0025070] An electrocardiographic finding of a small hump following the T wave occurring during the final phase of Purkinje repolarization. [url:http://purl.obolibrary.org/obo/NCIT_C71089] U wave U waves U-wave PMID:8586480 MIO:00946 Three different patterns of the electrocardiogram were defined: (A) Tall symmetric T waves in the involved leads; (B) ST segment elevation > 0.1 mV in two or more adjacent leads; and (C) ST segment elevation together with distortion of the terminal portion of the QRS complex in two or more adjacent leads.[PMID:8586480] electrocardiogram pattern PMID:9207646 MIO:00947 The high resolution D is the slope of the line relating log (relative counts) to log (interval lengths)——that is, log C(r) = alpha + beta log (r), determined by linear regression using the method of least squares.[PMID:9207646] high resolution D PMID:1516189 MIO:00948 p(VT) = 1/[1+exp (6.2-0.11 low-amplitude signal durations-0.01 area ratio) [PMID:1516189] p(VT) PMID:24642467 MIO:00949 Periodic repolarization dynamics (PRD) is a novel electrocardiographic phenomenon that refers to sympathetic activity-associated low-frequency modulations of cardiac repolarization.[PMID:24642467] periodic repolarization dynamics PMID:10946049 MIO:00950 QTB =QT/RR^(1/2) [PMID:10946049] QTB interval PMID:10946049 MIO:00951 QTS =QT+0.154*(1-RR) [PMID:10946049] QTS interval PMID:17604046 MIO:00952 The resolution of 2 or more ECG stages during the first 48 hours after infarct-related artery recanalization was considered a rapid change.[PMID:17604046] rapid electrocardiographic stage changes MIO:00953 extreme deviation of mean QRS axis to the right PMID:18242541 MIO:00954 Repolarization scatter (RTI:DI(StdErr)) was then calculated as the standard error about the RTI:DI regression line. [PMID:18242541] RTI:DI(StdErr) PMID:2353645 MIO:00955 the ratio of sum of R-wave amplitude (sigma R) to sum of ST segment elevation [PMID:2353645] sigma R/sigma ST PMID:11786941 MIO:00956 The ST/HR slope was determined by linear regression analysis to relate the amount of ST segment elevation to the heart rate.[PMID:11786941] ST/HR slope PMID:31066723 MIO:00957 These ECG changes, also known as STEMI equivalents, include de Winter ST/T-wave complex, N wave (delayed activation wave), T-wave precordial instability, and posterior myocardial infarction. [PMID:31066723] STEMI equivalents PMID:15120052 MIO:00958 The stress-recovery index, defined as the difference in absolute values of the areas designated by ST depression in the heart-rate domain during exercise and recovery. [PMID:15120052] stress-recovery index PMID:23251630 MIO:00959 SAI QRST was regressed on QRS width, mean magnitude of spatial QRS and T vectors, 3D J-point deviation amplitude (interloop distance) and QT duration.[PMID:23251630] sum absolute QRST integral SAI QRST PMID:16337496 MIO:00960 Turbulence dynamics was assessed as the slope of the regression line between turbulence slope and heart rate (VPC). [PMID:16337496] turbulence dynamics PMID:23228925 MIO:00961 Monomorphic VT with CL >= 200 ms lasting at least 10 s or requiring cardioversion due to haemodynamic instability was considered a positive study. [PMID:23228925] ventricular tachycardia cycle length PMID:28236543 MIO:00962 The V-index is a metric derived by combining a statistical model of the myocytes' repolarization times with an electrophysiological model describing the generation of the ECG starting from the action potential of individual cells. [PMID:28236543] V-index PMID:8522710 MIO:00963 Wavelet correlation functions of the signal-averaged ECG were evaluated in a time-frequency plane ranging from 25 ms before QRS onset to 25 ms after QRS offset in the frequency range between 40 and 100 Hz. [PMID:8522710] wavelet correlation functions of the signal-averaged ECG PMID:15508659 MIO:00964 AMSA represents a numerical value based on the sum of the magnitude of the weighted frequency spectrum between 3 and 48 Hz. The greater the AMSA value, the greater was the probability of reversal of ventricular fibrillation. [url:https://pubmed.ncbi.nlm.nih.gov/15508659/] amplitude spectrum area AMSA amplitude spectral area PMID:8733084 MIO:00965 During the test, T wave normalization was defined as a resting negative T wave becoming upright in one or more ECG leads during stress. [url:https://pubmed.ncbi.nlm.nih.gov/8733084/] dobutamine-induced T wave normalization T wave normalization during dobutamine stress testing stress-induced T wave normalization EFO:0007885 MIO:00966 measurement of the repolarisation phase of the heart's electrical cycle, defined as the difference between the duration of the QT interval and duration of the QRS interval [url:http://www.ebi.ac.uk/efo/EFO_0007885] JT interval EFO:0004462 MIO:00967 A PR interval is an electrocardiography measurement which measures from the beginning of the P wave to the beginning of the QRS complex in the heart's electrical cycle [url:http://www.ebi.ac.uk/efo/EFO_0004462] PR interval ECG:000001071 MIO:00968 An angle between ventricular depolarization (i.e., the QRS Wave Complex) and repolarization (i.e., the T Wave). See Yamazki, T et al., (2005) Heart Rhythm. 2(1):73-78. [url:http://www.cvrgrid.org/files/ECGOntologyv1.owlECG_000001071] QRS-T angle QRS/T angle QRS/T angles angle between the QRS vector and the T-wave vector fQRS-T angle spatial QRS-T angle PMID:15851335 MIO:00969 The QT/RR variability ratio (VR) was calculated as the standard deviation of all QT intervals during 24 hours (SDQT) divided by the standard deviation of all RR intervals (SDNN)-would be of prognostic value. [url:https://pubmed.ncbi.nlm.nih.gov/15851335/] QT/RR variability ratio QT-RR variability QT/RR interval slope QT/RR slope PMID:10404857 MIO:00970 The ratio between the levels of S wave amplitude and R wave amplitude. S/R wave ratio BCIO:010111 ExO:0000111 NCIT:C46110 MIO:00971 An individual who reports belonging to the cultural gender role distinction of female. [url:http://purl.obolibrary.org/obo/NCIT_C46110] female gender female female sex females girl woman women NCIT:C154421 MIO:00972 A person whose gender identity or gender expression differs from their assigned sex. [url:http://purl.obolibrary.org/obo/NCIT_C154421] transgender transfer patient PMID:22950360 MIO:00973 The measured values of HRT parameters have been shown to be a statistically significant predictor of the probability of dying from cardiac disease after a patient suffers a myocardial infarction. HRT can also be used to predict death in patients with congestive heart failure from a lethal arrhythmia.[url:https://en.wikipedia.org/wiki/Heart_rate_turbulence] Heart rate turbulence (HRT) is the return to equilibrium of heart rate after a premature ventricular contraction (PVC). It consists of a brief speed-up in heart rate, followed by a slow decrease back to the baseline rate. An important feature of HRT is that PVCs occur naturally in most adults, so measuring the characteristics of a given person's HRT offers a noninvasive way to evaluate his or her cardiac function without applying artificial external stimuli. [url:https://en.wikipedia.org/wiki/Heart_rate_turbulence] heart rate turbulence HRT heart rate turbulence (HRT) CMO:0002812 EFO:0008003 MIO:00974 A variability measurement in which the mean is calculated from the standard deviations or the standard deviation is calculated from the means of sequential one hour heart rate measurements. [url:http://purl.obolibrary.org/obo/CMO_0002812] heart rate variability HRV RR variability cycle length variability cyclic variation of heart rate MIO:00975 nighttime heart rate PMID:27593860 MIO:00976 If there were more than 2 poles, it was defined as a non-dipole pattern.[PMID:27593860] non-dipole pattern EFO:0009185 MIO:00977 Quantification of heart rate during a recovery period following exercise. [url:http://www.ebi.ac.uk/efo/EFO_0009185] heart rate response to recovery post exercise HR recovery after exercise test heart rate recovery after exercise heart rate recovery post exercise OMIT:0028737 MIO:00978 Respiratory sinus arrhythmia (RSA) is typically a benign, normal variation in heart rate that occurs during each breathing cycle: the heart rate increases when breathing in and decreases when breathing out. [url:https://en.wikipedia.org/wiki/Vagal_toneRespiratory_sinus_arrhythmia] respiratory sinus arrhythmia RSA EFO:0004351 MIO:00979 quantification of the number of times the heart beats in a given time interval, usually a minute, while the body is at rest [url:http://www.ebi.ac.uk/efo/EFO_0004351] resting heart rate resting heart rate (RHR) PMID:31206405 MIO:00980 Age shock index (age SI) is defined as age multiplied by SI. [url:https://pubmed.ncbi.nlm.nih.gov/31206405/] age shock index age SI PMID:31206405 MIO:00981 The modified shock index (MSI), which is the ratio of heart rate to mean arterial pressure. [url:https://pubmed.ncbi.nlm.nih.gov/31206405/] modified shock index MSI SIO:000832 MIO:00982 negative emotion is an emotion that does not feel good. [url:http://semanticscience.org/resource/SIO_000832] negative emotion SIO:000831 MIO:00983 A positive emotion is an emotion that feels good. [url:http://semanticscience.org/resource/SIO_000831] positive emotion SNOMED:160895006 MIO:00984 stopped work NCIT:C25172 MIO:00985 The state of being engaged in an activity or service for wages or salary. [url:http://purl.obolibrary.org/obo/NCIT_C25172] employed employment NCIT:C70696 MIO:00986 Financial coverage provided through third party reimbursement, that is designed to minimize monetary loss associated with health care costs. [url:http://purl.obolibrary.org/obo/NCIT_C70696] private health insurance private insurance NCIT:C307 MIO:00987 Biotechnology-derived pharmaceutical agents made from living organisms or their products. Includes recombinant proteins, monoclonal antibodies, and nucleic acids. [url:http://purl.obolibrary.org/obo/NCIT_C307] low job control decreased job control NCIT:C85868 MIO:00988 Without a stable or permanent residence. [url:http://purl.obolibrary.org/obo/NCIT_C85868] homeless NCIT:C168308 MIO:00989 An indication that an individual lives alone. [url:http://purl.obolibrary.org/obo/NCIT_C168308] lives alone living alone NCIT:C51776 MIO:00990 Indicates a person whose marriage has been legally dissolved and has not remarried. [url:http://purl.obolibrary.org/obo/NCIT_C51776] divorced divorce divorced status NCIT:C51773 MIO:00991 Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together. [url:http://purl.obolibrary.org/obo/NCIT_C51773] married married status NCIT:C150747 MIO:00992 An indication that an individual has married, after already having been married at least once. [url:http://purl.obolibrary.org/obo/NCIT_C150747] remarried NCIT:C150721 MIO:00993 Unwed. [url:http://purl.obolibrary.org/obo/NCIT_C150721] single MIO:00994 Depressive personality disorder (also known as melancholic personality disorder) is a psychiatric diagnosis that denotes a personality disorder with depressive features. [url:https://en.wikipedia.org/wiki/Depressive_personality_disorder] depressive personality disorder melancholic personality disorder HP:0000712 MIO:00995 Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or out of proportion to events and circumstances. [url:http://purl.obolibrary.org/obo/HP_0000712] emotional lability emotional instability mood alterations mood changes mood lability MF:0000063 OMIT:0006344 MIO:00996 Associated Adjectives: active, assertive, energetic, enthusiastic, outgoing, talkative.[url:http://purl.obolibrary.org/obo/MF_0000063] A personality trait manifesting itself in individual behavioral characteristics that are perceived as positive, assertive, social, and outgoing. [url:http://purl.obolibrary.org/obo/MF_0000063] extraversion OMIT:0008556 MIO:00997 introversion OMIT:0014342 MIO:00998 superego OMIT:0015270 MIO:00999 The hypothesis describes Type A individuals as outgoing, ambitious, rigidly organized, highly status-conscious, impatient, anxious, proactive, and concerned with time management. People with Type A personalities are often high-achieving "workaholics". They push themselves with deadlines, and hate both delays and ambivalence. [url:https://en.wikipedia.org/wiki/Type_A_and_Type_B_personality_theoryType_A] type A personality type A behavior type A behavior pattern type A behaviour OMIT:0028438 MIO:01000 type D personalityType D personality, a concept used in the field of medical psychology, is defined as the joint tendency towards negative affectivity (e.g. worry, irritability, gloom) and social inhibition (e.g. reticence and a lack of self-assurance). The letter D stands for "distressed". [url:https://en.wikipedia.org/wiki/Type_D_personality] type D personality NCIT:C41260 MIO:01001 A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, including for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam. (OMB) [url:http://purl.obolibrary.org/obo/NCIT_C41260] Asian Asian Ancestry Asians NCIT:C16352 MIO:01002 A person having origins in any of the Black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American". (OMB) [url:http://purl.obolibrary.org/obo/NCIT_C16352] Black or African American NCIT:C154875 MIO:01003 The native people of Australia. [url:http://purl.obolibrary.org/obo/NCIT_C154875] Aboriginal Australian HANCESTRO:0567 NCIT:C41226 MIO:01004 Denotes a person of African ancestral origins whose family settled in the Caribbean region. [url:http://purl.obolibrary.org/obo/NCIT_C41226] African Caribbean African Caribbean Ancestry African Caribbean Descent Afro-Caribbean ExO:0000145 MIO:01005 A person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. [url:http://purl.obolibrary.org/obo/ExO_0000145] Hispanic Hispanics NCIT:C158274 MIO:01006 The native people of New Zealand. [url:http://purl.obolibrary.org/obo/NCIT_C158274] Maori NCIT:C41261 MIO:01007 A person having origins in any of the original peoples of Europe, the Middle East, or North Africa. (OMB) [url:http://purl.obolibrary.org/obo/NCIT_C41261] White Caucasian Caucasians Caucasoid Occidental Whites MIO:01008 lack of partnership NCIT:C17953 MIO:01009 An indication of the years of schooling completed in graded public, private, or parochial schools, and in colleges, universities, or professional schools. [url:http://purl.obolibrary.org/obo/NCIT_C17953] education level EDULEVEL education education level education level completed educational attainment educational level level of education attained SNOMED:160932005 MIO:01010 financial problem financial difficulties NCIT:C41150 MIO:01011 A gain or recurrent benefit during a period of time, usually measured in money that derives from capital or labor. [url:http://purl.obolibrary.org/obo/NCIT_C41150] income income level NCIT:C25193 MIO:01012 The principal activity that a person does to earn money. [url:http://purl.obolibrary.org/obo/NCIT_C25193] occupation EMPJOB employee job employment category job occupation type MIO:01013 neighborhood socioeconomic status nSES neighborhood SES NCIT:C67145 MIO:01014 Indicates a person who has smoked at least 100 cigarettes in his or her lifetime and who currently smokes every day. [url:http://purl.obolibrary.org/obo/NCIT_C67145] current every day smoker current every day smoking daily conventional cigarette smoking daily smoker daily smoking every day smoker MIO:01015 Indicates a person who has smoked at least 100 cigarettes in his or her lifetime, who smokes now, but does not smoke every day. [url:http://purl.obolibrary.org/obo/NCIT_C67146] current some day smoker non-daily smoker non-daily smoking occasional smoker some day cigarette smoking some day smoker NCIT:C118254 MIO:01016 A sedentary activity level. [url:http://purl.obolibrary.org/obo/NCIT_C118254] inactivity PMID:29572325 MIO:01017 diabetes mellitus with complications DM with complications EFO:0009706 MIO:01018 Latent autoimmune diabetes in adults (LADA) is a form of diabetes mellitus type 1 that occurs in adulthood, often with a slower course of onset than type 1 diabetes diagnosed in juveniles.[url:http://www.ebi.ac.uk/efo/EFO_0009706] latent autoimmune diabetes in adults LADA NCIT:C177763 PMID:22279115 MIO:01019 Diabetes mellitus that does not show any evidence of tissue or organ damage. [url:http://purl.obolibrary.org/obo/NCIT_C177763] uncomplicated diabetes mellitus diabetes mellitus without complications diabetes without complications diabetes without end organ damage uncomplicated diabetes NCIT:C80398 MIO:01020 History of a first-degree relative (less than 55 years for male relatives or less than 65 years for female relatives) having had any of the following: coronary artery disease, myocardial infarction, coronary artery bypass graft surgery, percutaneous coronary intervention, or sudden cardiac death without obvious cause. [url:http://purl.obolibrary.org/obo/NCIT_C80398] family history of coronary artery disease family history of CAD family history of CHD family history of coronary artery diseases family history of coronary heart disease SNOMED:297242006 MIO:01021 family history of ischemic heart disease family history of IHD SNOMED:117361000119104 MIO:01022 family history of sudden cardiac death family history of SCD family history of sudden death MONDO:0005081 MIO:01023 Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia. [url:http://purl.obolibrary.org/obo/MONDO_0005081] preeclampsia pre-eclampsia NCIT:C3120 MIO:01024 Elevated pulmonary vascular pressure. A disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder. Increased pressure within the pulmonary circulation due to lung or heart disorder. [url:http://purl.obolibrary.org/obo/NCIT_C3120] pulmonary hypertension OAE:0002304 MIO:01025 Severe hypertension AE is a hypotension AE that shows severe sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. [url:http://purl.obolibrary.org/obo/OAE_0002304] severe hypertension HP:0001513 NCIT:C3283 PMID:29083808 UMLS:C0028754 MIO:01026 Having a high amount of body fat (body mass index [BMI] of 30 or more). [url:http://purl.obolibrary.org/obo/NCIT_C3283] obesity BMI 30+ adiposity body mass index 30+ body mass index more than 30 having too much body fat obese NCIT:C94250 UMLS:C0497406 MIO:01027 A condition in which body mass index falls between 25 and 29.9. Being too heavy for one's height. Excess body weight can come from fat, muscle, bone, and/or water retention. Being overweight does not always mean being obese. [url:http://purl.obolibrary.org/obo/NCIT_C94250] overweight BMI 25-29.9 body mass index 25-29.9 body mass index of 25 to 30 MIO:01028 age 55 years or older above 54 years of age age >/=55 years age >54 years age above 54 years age of more than 54 age over 54 years age ≥55 years aged >54 years aged over 54 aged over 54 years at least 55 years of age at least 55 years old over 54 years of age over 54 years old PMID:27032692 MIO:01029 travelling work (at least 3 nights per week away from home, also called ‘work on demand’) travelling work MIO:01030 acute anterior non-ST elevation myocardial infarction acute anterior NSTEMI acute anterior non-Q wave MI acute anterior non-Q wave myocardial infarction anterior non-Q wave AMI SNOMED:703164000 MIO:01031 acute anterior ST elevation myocardial infarction acute ST segment elevation myocardial infarction of anterior wall acute STEMI of anterior wall acute anterior ST segment elevation myocardial infarction acute anterior STEMI anterior acute STEMI SNOMED:703252002 MIO:01032 acute myocardial infarction of anterior wall involving right ventricle SNOMED:15712881000119105 MIO:01033 acute anterolateral ST elevation myocardial infarction acute ST segment elevation myocardial infarction of anterolateral wall acute anterolateral ST segment elevation myocardial infarction acute anterolateral STEMI acute anterolateral wall ST elevation myocardial infarction SNOMED:62695002 MIO:01034 acute anteroseptal ST elevation myocardial infarction acute ST segment elevation myocardial infarction of anteroseptal wall acute anteroseptal ST segment elevation myocardial infarction MIO:01035 acute inferior non-ST elevation myocardial infarction acute NSTEMI of inferior wall acute inferior NSTEMI acute inferior non-ST elevation MI acute inferior non-ST segment elevation myocardial infarction acute inferior wall NSTEMI acute non-Q-wave myocardial infarction of inferior wall inferior acute NSTEMI inferior acute non-ST elevation myocardial infarction inferior non-Q-wave AMI inferior non-Q-wave acute myocardial infarction non-Q-wave acute inferior myocardial infarction non-Q-wave acute myocardial infarction of inferior wall SNOMED:703213009 MIO:01036 acute inferior ST elevation myocardial infarction acute ST segment elevation myocardial infarction of inferior wall acute inferior Q-wave myocardial infarction acute inferior ST elevation MI acute inferior STEMI inferior Q-wave AMI inferior Q-wave acute myocardial infarction SNOMED:703251009 MIO:01037 acute myocardial infarction of inferior wall involving right ventricle SNOMED:12238111000119106 MIO:01038 acute inferolateral ST elevation myocardial infarction acute ST segment elevation myocardial infarction of inferolateral wall SNOMED:59063002 MIO:01039 acute apical-lateral myocardial infarction acute myocardial infarction of apical-lateral wall SNOMED:282006 MIO:01040 acute basal-lateral myocardial infarction acute myocardial infarction of basal-lateral wall NCIT:C102593 SNOMED:64627002 MIO:01041 An electrocardiographic finding of pathologic Q waves with accompanying ST elevation in leads I and aVL, which is suggestive of acute myocardial infarction of the high lateral wall of the left ventricle. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C102593] acute high-lateral myocardial infarction acute myocardial infarction of high lateral wall SNOMED:15712921000119103 MIO:01042 acute lateral ST elevation myocardial infarction acute ST segment elevation myocardial infarction of lateral wall MIO:01043 acute non-ST elevation myocardial infarction with non-obstructive coronary arteries acute NSTEMI with non-obstructive coronary arteries acute NSTEMI without obstructive CAD MIO:01044 acute ST elevation myocardial infarction with non-obstructive coronary arteries MIO:01045 acute type 1 non-ST elevation myocardial infarction acute type 1 NSTEMI acute type 1 non-ST elevation MI acute type I NSTEMI acute type I non-ST elevation MI MIO:01046 acute type 2 non-ST elevation myocardial infarction acute type 2 NSTEMI acute type 2 non-ST segment elevation myocardial infarction acute type II non-ST elevation myocardial infarction SNOMED:15713041000119103 MIO:01047 acute posterior ST elevation myocardial infarction acute ST segment elevation myocardial infarction of posterior wall SNOMED:15713201000119105 MIO:01048 acute posterobasal ST elevation myocardial infarction acute ST segment elevation myocardial infarction of posterobasal wall SNOMED:12238151000119107 MIO:01049 acute posteroinferior ST elevation myocardial infarction acute ST segment elevation myocardial infarction of inferoposterior wall acute inferoposterior ST elevation myocardial infarction SNOMED:15712841000119100 MIO:01050 acute posterolateral ST elevation myocardial infarction acute ST segment elevation myocardial infarction of posterolateral wall MIO:01051 old anterior ST elevation myocardial infarction old anterior ST elevation MI old anterior ST segment elevation myocardial infarction old anterior STEMI SNOMED:194857001 MIO:01052 subsequent ST elevation myocardial infarction of anterior wall SNOMED:194858006 MIO:01053 subsequent ST elevation myocardial infarction of inferior wall NCIT:C119223 PMID:30571511 MIO:01054 Myocardial infarction associated with percutaneous coronary intervention (PCI). [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] type 4a myocardial infarction coronary intervention–related MI post-PCI myocardial infarction post-percutaneous coronary intervention myocardial infarction type 4a MI type IVa MI type IVa myocardial infarction NCIT:C119224 PMID:30571511 MIO:01055 Myocardial infarction associated with stent thrombosis as documented by angiography or at autopsy. A subcategory of PCI-related MI is stent/scaffold thrombosis, type 4b MI, as documented by angiography or autopsy using the same criteria utilized for type 1 MI. It is important to indicate the time of the occurrence of the stent/scaffold thrombosis in relation to the timing of the PCI procedure. The following temporal categories are suggested: acute, 0 to 24 hours; subacute, >24 hours to 30 days; late, >30 days to 1 year; and very late >1 year after stent/scaffold implantation. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] type 4b myocardial infarction type 4b MI type IVb MI type IVb myocardial infarction NCIT:C119225 PMID:30571511 MIO:01056 Restensosis associated with percutaneous coronary intervention. Occasionally MI occurs and—at angiography, in-stent restenosis, or restenosis following balloon angioplasty in the infarct territory—is the only angiographic explanation since no other culprit lesion or thrombus can be identified. This PCI-related MI type is designated as type 4c MI, defined as focal or diffuse restenosis, or a complex lesion associated with a rise and/or fall of cTn values above the 99th percentile URL applying, the same criteria utilized for type 1 MI. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] type 4c myocardial infarction type 4c MI type IVc MI type IVc myocardial infarction OAE:0000001 MIO:01057 a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. [url:http://purl.obolibrary.org/obo/OAE_0000001] adverse events adverse clinical outcomes adverse event adverse outcome adverse outcomes composite outcomes major adverse clinical events major adverse clinical outcomes major adverse coronary events net adverse clinical events poor outcomes unfavorable outcomes MIO:01058 left ventricular function recovery LV function improvement LV function recovery LV functional recovery LV recovery functional recovery improvement of ventricular function left ventricular functional improvement left ventricular recovery left ventricular wall motion recovery recovery of LV function recovery of impaired LV function recovery of left ventricular function recovery of left ventricular wall motion recovery of regional left ventricular function regional functional recovery regional wall motion recovery segmental functional improvement wall motion recovery NCIT:C17177 MIO:01059 Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival. [url:http://purl.obolibrary.org/obo/NCIT_C17177] survival survivorship survivorship issues PMID:27546353 SNOMED:251057006 MIO:01060 A fixed perfusion defect was defined as a perfusion defect on stress images in >/=2 contiguous segments or slices, which persists on rest images. fixed myocardial perfusion defect fixed perfusion defect PMID:34322304 MIO:01061 It was defined by Thrombolysis In Myocardial Infarction (TIMI) flow grade following pPCI or of 0, 1 or 2 of the infarct-related artery. [url:https://pubmed.ncbi.nlm.nih.gov/34322304/] reperfusion failure TIMI < or =2 flow absence of reperfusion absence of successful clinical reperfusion failed coronary reperfusion therapy failed reperfusion failure of reperfusion impaired angiographic reperfusion impaired microvascular reperfusion impaired myocardial reperfusion insufficient reperfusion nonreperfusion unfavorable myocardial reperfusion unfavorable reperfusion unsuccessful coronary thrombolysis unsuccessful reperfusion worse reperfusion PMID:27546353 SNOMED:251055003 MIO:01062 A reversible perfusion defect was defined as a perfusion defect on stress mages that partially or completely resolved at rest in >/=2 contiguous segments or slices. [url:https://pubmed.ncbi.nlm.nih.gov/27546353/] reversible myocardial perfusion defect residual contrast defect reversible defect reversible ischemia reversible perfusion defect NCIT:C76245 MIO:01063 A system used to group human blood into different types, based on the presence or absence of certain markers on the surface of red blood cells. The four main blood types are A, B, O, and AB. For a blood transfusion, the ABO blood group system is used to match the blood type of the donor and the person receiving the transfusion. People with blood type O can donate blood to anyone and are called universal donors. People with blood type AB can accept blood from all donors and are called universal recipients. People with type A or B can receive matching blood or type O blood. [url:http://purl.obolibrary.org/obo/NCIT_C76245] ABO blood group ABO blood group system ABO type NCIT:C16669 MIO:01064 The state of a subject's mental or physical condition. [url:http://purl.obolibrary.org/obo/NCIT_C16669] health status NCIT:C142570 MIO:01065 A multi-domain concept that represents the patient's general perception of the effect of illness and treatment on physical, psychological, and social aspects of life. NOTE: Claiming a statistical and meaningful improvement in HRQoL implies: (1) that all HRQoL domains that are important to interpreting change in how the clinical trial's population feels or functions as a result of the targeted disease and its treatment were measured; (2) that a general improvement was demonstrated; and (3) that no decrement was demonstrated in any domain. [FDA Clinical Outcome Assessment (COA) Glossary] Compare to quality of life (QoL). [url:http://purl.obolibrary.org/obo/NCIT_C142570] health-related quality of life HRQoL health-related quality of life (HRQoL) CHEBI:35674 NCIT:C270 PMID:30563358 UMLS:C0003364 MIO:01066 Unlike lipid management with high-intensity statins where a single drug will suffice, most patients with hypertension will require 2 or 3 blood pressure medications to achieve the recommended targets.[url:https://pubmed.ncbi.nlm.nih.gov/30563358/] Any substance used in the treatment of acute or chronic hypertension regardless of pharmacological mechanism. Antihypertensive agents include diuretics, alpha-adrenergic and beta-adrenergic antagonists, angiotensin-converting enzyme inhibitors, calcium channel blockers, ganglionic blockers, and vasodilator agents. [url:http://purl.obolibrary.org/obo/NCIT_C270] antihypertensive agent antihypertensive agents antihypertensive drug antihypertensive drugs antihypertensive therapy antihypertensive treatment antihypertensives hypotensive drug hypotensive drugs CHEBI:87631 MIO:01067 The available evidence indicates clear and conclusive benefits of statins in the primary prevention of MI and stroke. In numerous randomized trials of over 170 000 patients in primary and secondary prevention, as well as their meta-analyses, statins produce both statistically and clinically significant reductions in MI and stroke as well as CVD and total mortality.[url:https://pubmed.ncbi.nlm.nih.gov/30563358/] Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that reduce illness and mortality in those who are at high risk of cardiovascular disease. They are the most common cholesterol-lowering drugs. [url:https://en.wikipedia.org/wiki/Statin] statin HMG-CoA reductase inhibitor HMG-CoA reductase inhibitors hydroxymethylglutaryl coenzymeA reductase inhibitor hydroxymethylglutaryl coenzymeA reductase inhibitors hydroxymethylglutaryl-coenzyme A reductase inhibitor statins CHEBI:15365 NCIT:C287 PMID:30563358 UMLS:C0004057 MIO:01068 If a clinician decides to prescribe aspirin in primary prevention, it is also important to educate patients since only 50% of patients prescribed the drug are taking it.[url:https://pubmed.ncbi.nlm.nih.gov/30563358/] An orally administered non-steroidal antiinflammatory agent. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties. [url:http://purl.obolibrary.org/obo/NCIT_C287] aspirin 2-(Acetyloxy)benzoic acid ASA acetylsalicylic acid aspergum empirin entericin extren measurin NCIT:C61686 MIO:01069 A thienopyridine, with antiplatelet activity. Clopidogrel targets, irreversibly binds to and alters the platelet receptor for adenosine diphosphate (ADP), thereby blocking the binding of ADP to its receptor, inhibiting ADP-mediated activation of the glycoprotein complex GPIIb/IIIa, and inhibiting fibrinogen binding to platelets and platelet adhesion and aggregation. This results in increased bleeding time. [url:http://purl.obolibrary.org/obo/NCIT_C61686] clopidogrel Plavix clopidogrel bisulfate NCIT:C29711 PMID:30563358 UMLS:C0935929 MIO:01070 Diabetes leads to macrovascular complications such as MI and stroke and microvascular complications, principally ocular and renal. Nonetheless, MI and stroke are far and away the leading causes of death in patients with type 2 diabetes, and heart failure is also a major cause of their hospitalizations and deaths.[url:https://pubmed.ncbi.nlm.nih.gov/30563358/] Any substance used to reduce hyperglycemia or treat disorders associated with diabetes. Based on their mechanism of action, this class of agents can be classified to the following groups: directly acting insulomimetics, which activates insulin receptors; indirectly acting insulinomimetics, which increase insulin release such as sulfonylureas or which potentiate the effect of insulin such as metformin; those act directly on the metabolism of glucose such as inhibitors of glucosidases and inhibitors of aldose reductase. [url:http://purl.obolibrary.org/obo/NCIT_C29711] anti-diabetic agent anti-diabetic agents anti-diabetics antidiabetic agent antidiabetic agents antidiabetic drug drug to treat diabetes drugs to treat diabetes NCIT:C76404 MIO:01071 Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y12 receptor. [url:https://en.wikipedia.org/wiki/Ticagrelor] ticagrelor (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol AR-C126532XX AZD6140 brilinta NCIT:C81566 MIO:01072 An orally bioavailable thienopyridine, with antiplatelet activity. Upon oral administration, the active metabolite of prasugrel targets and irreversibly binds to the platelet receptor for adenosine diphosphate (ADP), thereby blocking the binding of ADP to its receptor. This inhibits ADP-mediated activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation. This results in increased bleeding time. [url:http://purl.obolibrary.org/obo/NCIT_C81566] prasugrel effient efient CHEBI:82702 NCIT:C152912 PMID:30178075 MIO:01073 Vorapaxar is an oral competitive selective inhibitor of thrombin receptor, PAR-1. Selective PAR-1 blockade has shown to cause potent inhibition of thrombin-induced platelet aggregation but preserves primary hemostatic function. [url:https://pubmed.ncbi.nlm.nih.gov/30178075/] vorapaxar ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate NCIT:C51999 SNOMED:41339005 MIO:01074 A procedure to enlarge the opening in a blood vessel that has become narrowed or blocked by plaque (a buildup of fat and cholesterol on the inner wall of the blood vessel). Examples of angioplasty are balloon angioplasty and laser angioplasty. An endovascular procedure used to widen diseased arteries resulting in increasing blood flow through the area. [url:http://purl.obolibrary.org/obo/NCIT_C51999] coronary angioplasty NCIT:C80413 MIO:01075 The passage of a catheter into the left ventricle for the purposes of angiography, measurement of ventricular pressures, and/or oxygen saturation. [url:http://purl.obolibrary.org/obo/NCIT_C80413] left heart catheterization left-sided heart catheterization NCIT:C80411 MIO:01076 A diagnostic procedure in which a catheter is guided into the right heart, where pressures may be measured and radiocontrast material may be injected to visualize blood flow in and around the right heart. [url:http://purl.obolibrary.org/obo/NCIT_C80411] right heart catheterization Swan-Ganz catheterization pulmonary artery catheterization right-sided heart catheterization NCIT:C80465 SNOMED:705637003 MIO:01077 A vascular metal mesh tube coated with medication. The drug coating is intended to lessen the likelihood of restenosis. [url:http://purl.obolibrary.org/obo/NCIT_C80465] drug-eluting stent placement DES drug eluting stent drug-eluting coronary artery stent placement drug-eluting stent drug-eluting stents implantation of coronary drug-eluting stent implantation of drug-eluting stent MIO:01078 number of stent NCIT:C80464 MIO:01079 A vascular metal mesh tube without a coating. [url:http://purl.obolibrary.org/obo/NCIT_C80464] bare-metal stent placement bare metal stent bare metal stents bare-metal stent bare-metal stents implantation of bare metal stent implantation of bare-metal stent MIO:01080 the stent is threaded through the lesion and expanded [url:https://en.wikipedia.org/wiki/Coronary_stent] direct stenting SNOMED:408706001 MIO:01081 stent diameter vascular stent diameter SNOMED:22953008 MIO:01082 repair of heart cardioplasty MIO:01083 nonelective coronary artery bypass grafting OMIT:0023939 MIO:01084 off-pump coronary artery bypass grafting OPCAB SNOMED:63697000 MIO:01085 Cardiopulmonary bypass (CPB) is a technique in which a machine temporarily takes over the function of the heart and lungs during surgery, maintaining the circulation of blood and the oxygen content of the patient's body. The CPB pump itself is often referred to as a heart–lung machine or "the pump". Cardiopulmonary bypass pumps are operated by perfusionists. CPB is a form of extracorporeal circulation. Extracorporeal membrane oxygenation is generally used for longer-term treatment. [url:https://en.wikipedia.org/wiki/Cardiopulmonary_bypass] cardiopulmonary bypass operation CPB cardiopulmonary bypass cardiopulmonary perfusion heart lung bypass NCIT:C171507 UMLS:C0015357 MIO:01086 A technique that utilizes a device to pump a patient's blood outside of the body, oxygenate it, and return it to the body. [url:http://purl.obolibrary.org/obo/NCIT_C171507] extracorporeal membrane oxygenation ECLS treatment ECMO ECMO treatment extracorporeal life support NCIT:C172591 MIO:01087 A type of mechanical circulatory support in which a balloon catheter inserted into the proximal descending aorta is inflated immediately after aortic valve closure in diastole and deflated just before aortic valve opening in systole, with the augmentation of coronary blood flow during diastole increasing coronary blood flow and systemic perfusion. [url:http://purl.obolibrary.org/obo/NCIT_C172591] intra-aortic balloon pump counterpulsation IABP intra-aortic balloon counterpulsation intra-aortic balloon pump intra-aortic balloon pump therapy intra-aortic balloon pumping intraaortic balloon pump NCIT:C80473 MIO:01088 A mechanical pump which also includes a control system and an energy supply. It receives blood from the left ventricle and delivers it to the aorta, thus helping the heart to pump sufficient blood to the body. [url:http://purl.obolibrary.org/obo/NCIT_C80473] left ventricular assist device MIO:01089 duration of percutaneous coronary intervention MIO:01090 multivessel percutaneous coronary intervention multivessel PCI MIO:01091 primary percutaneous coronary intervention direct PCI direct percutaneous coronary intervention emergency PCI emergency percutaneous coronary intervention primary PCI urgent PCI urgent percutaneous coronary intervention PMID:33817772 MIO:01092 Thrombus aspiration (TA) before PPCI has been proposed as a useful treatment to reduce oxidative stress and distal embolization, thereby improving microvascular perfusion and reducing no-reflow phenomena. [url:https://pubmed.ncbi.nlm.nih.gov/33817772/] thrombus aspiration TA thrombosis aspiration NCIT:C168093 MIO:01093 Surgery performed with the purpose of replacing a degenerated, calcified, malformed, dysfunctional, etc. cardiac valve with a bioprosthetic, homograft, or autograft valve. [url:http://purl.obolibrary.org/obo/NCIT_C168093] valve replacement NCIT:C119202 UMLS:C0877341 MIO:01094 Any procedure that is undertaken to reestablished blood flow to the heart. [url:http://purl.obolibrary.org/obo/NCIT_C119202] coronary revascularization coronary revascularization procedure heart revascularization revascularization SNOMED:233505002 MIO:01095 lower limb revascularization revascularisation of lower limb revascularization of lower limb NCIT:C263 UMLS:C0003280 MIO:01096 Any agent capable of preventing blood clot formation. [url:http://purl.obolibrary.org/obo/NCIT_C263] anticoagulant agent anticoagulant anticoagulant agents anticoagulant drugs anticoagulants anticoagulation anticoagulation therapy anticoagulation treatment blood thinner NCIT:C1327 SNOMED:438486002 MIO:01097 An agent that inhibits platelet aggregation and reduces coagulation in the circulatory system. [url:http://purl.obolibrary.org/obo/NCIT_C1327] antiplatelet agent anti-platelet agent anti-platelet agents anti-platelet drug anti-platelet drugs anti-platelet therapy anti-platelet treatment antiplatelet agents antiplatelet drug antiplatelet drugs antiplatelet therapy antiplatelet treatment NCIT:C448 MIO:01098 A class of agents that increases the production of urine by the kidney. Via various mechanism of actions, diuretics retain water in urine, thus provides a means of forced diuresis. [url:http://purl.obolibrary.org/obo/NCIT_C448] diuretic diuretics NCIT:C29730 UMLS:C1512185 MIO:01099 Any agent or mixture of agents that are used to replenish electrolytes in body fluids, such as sodium, potassium, calcium, magnesium, phosphorus, chloride and bicarbonate. [url:http://purl.obolibrary.org/obo/NCIT_C29730] electrolyte replacement agent NCIT:C47793 UMLS:C0003195 MIO:01100 Agents used for the treatment or prevention of cardiac arrhythmias; they may effect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. [url:http://purl.obolibrary.org/obo/NCIT_C47793] antiarrhythmic agent anti-arrhythmic agent antiarrhythmic agents antiarrhythmic drug antiarrhythmic drugs antiarrhythmic therapy cardiac depressant CHEBI:137431 NCIT:C126567 MIO:01101 Any substance used in the treatment of hypotension. A vasopressor agent increases reduced blood pressure. [url:http://purl.obolibrary.org/obo/NCIT_C126567] antihypotensive agent anti-hypotensive agent antihypotensive agents pressor pressors vasopressor vasopressor agens vasopressor agent SNOMED:373267003 MIO:01102 antilipemic agent NCIT:C78322 MIO:01103 Any agent having a favorable effect on the function of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C78322] cardiotonic agent cardiotonic agents cardiotonic drug cardiotonic drugs MAXO:0000190 MIO:01104 Treatment with Renin-angiotensin-aldosterone system (RAAS) inhibitors, a group of drugs that act by inhibiting the renin-angiotensin-aldosterone system and include angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), and direct renin inhibitors [url:http://purl.obolibrary.org/obo/MAXO_0000190] RAAS inhibitor ACE/ARB ACEI/ARB therapy ACEIs/ARBs therapy RAAS inhibitor therapy angiotensin-converting enzyme inhibitors/angiotensin receptor blocker renin-angiotensin-aldosterone system inhibitor treatment with RAAS inhibitor treatment with renin-angiotensin-aldosterone system inhibitor CHEBI:35620 NCIT:C29707 UMLS:C0042402 MIO:01105 Any agent that causes widening of blood vessels as a result of smooth muscle relaxation. [url:http://purl.obolibrary.org/obo/NCIT_C29707] vasodilating agent vasodilator NCIT:C166829 MIO:01106 Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient. [url:https://en.wikipedia.org/wiki/Calcium_dobesilate] calcium dobesilate NCIT:C65385 MIO:01107 A substance used to make drugs that are used to treat several heart conditions, including congestive heart failure. Digitalis is made from the dried leaves of Digitalis purpurea (common foxglove) plants. It is a type of cardiac glycoside. [url:http://purl.obolibrary.org/obo/NCIT_C65385] digitalis digifortis digiglusin NCIT:C170012 MIO:01108 fulacimstat fulacimstat CHEBI:35480 MIO:01109 An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. [url:http://purl.obolibrary.org/obo/CHEBI_35480] analgesic agent analgesic analgesic drug analgesic drugs analgesics anodynes antinociceptive agent antinociceptive agents pain-relief medication painkiller CHEBI:66991 MIO:01110 sympatholytic agent sympatholytic sympatholytic agents sympatholytic drug sympatholytic drugs sympatholytics NCIT:C98150 UMLS:C3273847 MIO:01111 An antilipidemic agent derived from fibric acid that lowers serum LDL cholesterol levels by activating peroxisome proliferator activated receptor alpha (PPARa). [url:http://purl.obolibrary.org/obo/NCIT_C98150] fibrate antilipidemic agent NCIT:C123926 MIO:01112 An orally bioavailable combination agent containing the cholesterol absorption inhibitor ezetimibe and the hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor simvastatin, with lipid-lowering activity. Upon oral administration, ezetimibe binds to the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1) at the brush border of the small intestine and inhibits the intestinal absorption of biliary and dietary cholesterol and related phytosterols. This decreases blood cholesterol levels, decreases the delivery of intestinal cholesterol to the liver, reduces hepatic cholesterol stores and enhances the clearance of cholesterol from the bloodstream. Upon administration of simvastatin and subsequent hydrolyzation to its active beta-hydroxyacid form, this statin competitively inhibits HMG-CoA reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, which is an essential step in cholesterol synthesis. Ezetimibe and simvastatin together reduce blood levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), very-low-density lipoproteins (VLDL), and apolipoprotein B (Apo B), and increase the plasma concentration of high-density lipoprotein cholesterol (HDL-C). Higher cholesterol blood levels appear to be associated with an increased risk in the proliferation of certain cancer cells, such as prostate cancer cells. [url:http://purl.obolibrary.org/obo/NCIT_C123926] ezetimibe/simvastatin Butanoic Acid, 2,2-Dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl Ester, Mixture with (3R,4S)-1-(4-Fluorophenyl)-3-((3S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-2-azetidinone Ezetimibe/Simvastatin simvastatin-ezetimibe vytorin NCIT:C200 MIO:01113 A synthetic N-acetyl derivative and prodrug of the endogenous amino acid L-cysteine, a precursor of the antioxidant glutathione (GSH), with mucolytic, antioxidant, and potential cytoprotective, cancer-preventive, and anti-inflammatory activities. Upon administration, acetylcysteine exerts its mucolytic activity by reducing disulfide bonds in mucoproteins, resulting in liquification of mucus and reducing its viscosity. It is also used for the treatment of acetaminophen overdose as it can restore the depleted GSH reserves in the hepatocytes during the process of detoxification. The antioxidant activity is attributed to the ability of GSH to scavenge reactive oxygen species (ROS), thereby preventing ROS-mediated cell damage, decreasing oxidative stress, protecting cells against the damaging effects of free radicals and preventing apoptosis in these cells. In addition, this may inhibit tumor cell proliferation, progression and survival, in susceptible tumor cells that rely on ROS-mediated signaling for their proliferation and malignant behavior. Under certain circumstances, acetylcysteine is able to induce apoptosis in susceptible cells, including certain tumor cells, via the intrinsic mitochondria-dependent pathway but not involving endoplasmic reticulum stress. Also, acetylcysteine may also be able to degrade Notch2, thereby preventing proliferation, migration, and invasion in Notch2-overexpressing glioblastoma cells. In addition, acetylcysteine may inhibit viral stimulation by reactive oxygen intermediates, thereby producing antiviral activity in HIV patients. Acetylcysteine also possesses anti-inflammatory activity through modulation of the nuclear factor-kappa B (NF-kB) pathway and the modulation of cytokine synthesis. [url:http://purl.obolibrary.org/obo/NCIT_C200] acetylcysteine L-Alpha-acetamido-beta-mercaptopropionic Acid N-Acetyl-L-cysteine N-Acetylcysteine N-acetyl cysteine N-acetyl-3-mercaptoalanine NAC acetadote acetylcysteine airbron broncholysin brunac fabrol fluatox fluimucetin fluimucil fluprowit muco sanigen mucocedyl mucolator mucolyticum mucomyst mucosolvin mucret neo-fluimucil parvolex respaire tixair NCIT:C942 MIO:01114 A natural fat-soluble antioxidant with potential chemopreventive activity. Also known as tocopherol, vitamin E ameliorates free-radical damage to biological membranes, protecting polyunsaturated fatty acids (PUFA) within membrane phospholipids and within circulating lipoproteins. Peroxyl radicals react 1000-fold faster with vitamin E than with PUFA. In the case of oxygen free radical-mediated tumorigenesis, vitamin E may be chemopreventive. [url:http://purl.obolibrary.org/obo/NCIT_C942] vitamin E 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol 5,7,8-Trimethyltocol E vitamin vitamin E compound NCIT:C39607 UMLS:C0032143 MIO:01115 A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. alteplase activase plasminogen activator (human tissue-type protein moiety) r-tPA recombinant tissue plasminogen activator rt-PA t-PA t-plasminogen activator tPA tissue plasminogen activator tissue plasminogen activator, recombinant NCIT:C95255 UMLS:C0591120 MIO:01116 A proteolytic enzyme and defibrinogenating agent derived from the venom of the Malayan pit viper, with profibrinolytic and anticoagulant activities. Upon administration, ancrod cleaves fibrinogen and releases A-fibrinopeptides. This inactivates fibrinogen and leads to a reduction in blood viscosity, increases blood flow and perfusion of the microcirculation. [url:http://purl.obolibrary.org/obo/NCIT_C95255] ancrod Acc-C abbott 38414 agkistrododon protein C activator agkistrododon rhodostoma venom proteinase arwin brevinase proteinase, sgkistrodon serine venacil venombin-A viprinex NCIT:C29750 UMLS:C0016018 MIO:01117 Any agent capable of dissolving an existing blood clot in order to reperfuse the blocked blood vessel. [url:http://purl.obolibrary.org/obo/NCIT_C29750] anistreplase NCIT:C79483 UMLS:C0035158 MIO:01118 A recombinant form of reptilase identical to or similar to the blood-coagulation factor X activator from the tropical snake Bothrops atrox. Orthologous to human thrombin, batroxobin activates soluble fibrinogen into fibrin and facilitates blood coagulation, thereby can be used in substitution of thrombin in quantitative thrombin time test. Furthermore, as a serine protease, batroxobin has the potential applications in cardiovascular treatments, such as dissolving thrombus, preventing thrombus formation and improving microcirculation. [url:http://purl.obolibrary.org/obo/NCIT_C79483] batroxobin DF 521 DF-521 batroxobin bhrombin-like enzyme batroxobin bothrops atrox blood-coagulation factor X activator bothrops venom proteinase defibrase hemostase reptilase NCIT:C96707 MIO:01119 lanoteplase 7-L-glutamine-245-L-methionine SUN 9216 lanoteplase NCIT:C166422 MIO:01120 Monteplase is an antithrombic proposed for use in acute myocardial infarction. [url:https://en.wikipedia.org/wiki/Monteplase] monteplase DRON:00013611 SNOMED:59082006 MIO:01121 Urokinase is used clinically as a thrombolytic agent in the treatment of severe or massive deep venous thrombosis, peripheral arterial occlusive disease, pulmonary embolism, acute myocardial infarction (AMI, heart attack), and occluded dialysis cannulas (catheter clearance). It is also administered intrapleurally to improve the drainage of complicated pleural effusions and empyemas. [url:https://en.wikipedia.org/wiki/Urokinase] recombinant urokinase UK abbokinase breokinase uPA urinary plasminogen activator urokinase urokinase-type plasminogen activator NCIT:C90972 UMLS:C0256103 MIO:01122 A recombinant, non-glycosylated deletion mutein of tissue plasminogen activator (tPA), a serine protease that catalyzes the cleavage of plasminogen to plasmin, with fibrinolytic activity. Upon administration, reteplase converts plasminogen to plasmin, thereby increasing plasmin enzymatic activity and resulting in degradation of the fibrin matrix of the thrombus and potential dissolution of a thrombus or embolism. [url:http://purl.obolibrary.org/obo/NCIT_C90972] reteplase BM-06022 CUSA 081 CUSA-081 CUSA081 human T-PA (Amino Acids 1-3 and 176-527) retavase NCIT:C152436 SNOMED:395889004 MIO:01123 streptokinase SK streptokinase NCIT:C29489 UMLS:C0872913 MIO:01124 A 527 amino acid glycoprotein and the modified form of the naturally occurring human plasminogen activator (tPA) with tissue plasminogen activating activity. Tenecteplase (TNKase) is a serine protease created by introducing substitutions of threonine 103 with asparagine, asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. TNKase converts fibrin-bound plasminogen to plasmin by cleaving the Arg/Val bond in plasminogen. Plasmin in turn degrades the fibrin matrix of the thrombus mass, thereby helps eliminate blood clots or arterial blockages that cause myocardial infarction. [url:http://purl.obolibrary.org/obo/NCIT_C29489] tenecteplase TNK-tPA TNK-tissue plasminogen activator TNKase NCIT:C12869 MIO:01125 One of four chambers of the heart, which receives blood from the pulmonary veins and pumps blood through the mitral valve into the left ventricle. [url:http://purl.obolibrary.org/obo/NCIT_C12869] left atrium left atrium left atrium of heart NCIT:C12868 MIO:01126 One of the four chambers of the heart, which is located immediately superior to the right ventricle, and which receives deoxygenated venous blood from the systemic circulation. [url:http://purl.obolibrary.org/obo/NCIT_C12868] right atrium NCIT:C12871 SNOMED:87878005 MIO:01127 The left lower chamber of the heart that receives blood from the left atrium and pumps it through the aorta to the body. [url:http://purl.obolibrary.org/obo/NCIT_C12871] left ventricle left cardiac ventricular structure left ventricle of heart left ventricular structure NCIT:C12870 SNOMED:53085002 MIO:01128 The lower chamber of the heart located in the right side. It receives blood from the right atrium that is no longer oxygenated and it pumps it to the pulmonary artery. [url:http://purl.obolibrary.org/obo/NCIT_C12870] right ventricle right cardiac ventricular structure right ventricle right ventricle of heart right ventricular structure FMA:64154 MIO:01129 anterior wall of heart MIO:01130 inferior wall of heart inferior wall NCIT:C127645 MIO:01131 The wall of the left ventricle, comprising anterior, inferior, lateral, apical, basal wall; and excluding the interventricular septum. [url:http://purl.obolibrary.org/obo/NCIT_C127645] left ventricular wall FMA:64155 MIO:01132 posterior wall of heart NCIT:C127649 MIO:01133 The wall of the right ventricle, comprising anterior, inferior, and lateral walls; and excluding the interventricular septum. [url:http://purl.obolibrary.org/obo/NCIT_C127649] right ventricular wall NCIT:C12372 MIO:01134 A blood vessel that carries blood away from the heart. [url:http://purl.obolibrary.org/obo/NCIT_C12372] artery arterial artery MIO:01135 left main coronary artery culprit lesion left main stem as infarct-related artery left main stem coronary artery lesion left main stem lesion PMID:17897129 MIO:01136 Proximal coronary culprit lesions were defined as occlusions occurring prior to the take-off of the first diagonal branch, the first obtuse marginal branch, and the right ventricular branch, in the case of the left anterior descending artery, left circumflex artery, and right coronary artery, respectively. [url:https://pubmed.ncbi.nlm.nih.gov/17897129/] proximal coronary culprit lesion proximal coronary culprit lesions proximal culprit coronary lesion MIO:01137 right coronary artery culprit lesion RCA culprit vessel RCA-related AMI right coronary artery of IRA PMID:20189566 MIO:01138 color grade of the plaques PMID:30913893 MIO:01139 Plaque erosion is defined as a thrombus contiguous to the luminal surface of a plaque without signs of rupture. Plaque erosion is a distinct entity caused primarily by endothelial erosion, compared with plaque rupture caused by inflammation. [url:https://pubmed.ncbi.nlm.nih.gov/30913893/] plaque erosion DCM:122389 MIO:01140 Plaque with a thin cap fibrous atheroma that is at increased risk of rupture and thrombosis (or re-thrombosis) and rapid stenosis progression. [url:http://dicom.nema.org/resources/ontology/DCM/122389] vulnerable plaque MIO:01141 infarct-related artery occlusion IRA occlusion occluded infarct-related artery HP:0025070 MIO:01142 U waves represent prolonged repolarisation of myocardial M cells. Under normal conditions the M cells are electrically coupled to adjacent cell layers. However, in conditions that produce electrical uncoupling, these M cells have significant effects on repolarisation producing prolonged rounded ST-T waves or U waves. The finding of U wave inversion on an ECG at rest or baseline is a non-specific finding. It is significant when observed post exercise, being originally described in early 1940s. Subsequent studies in the late 1970s, demonstrated a significant correlation of U wave inversion with either left main or LAD disease.[url:http://purl.obolibrary.org/obo/HP_0025070] An anomaly of the U wave of the electrocardiogram (EKG). The U wave is a small (0.5 mm) deflection immediately following the T wave, usually in the same direction as the T wave. It is best seen in leads V2 and V3. [url:http://purl.obolibrary.org/obo/HP_0025070] abnormal U wave SNOMED:164861001 MIO:01143 electrocardiographic myocardial ischemia ECG ischemia electrocardiographic myocardial ischaemia ischaemic ECG ischaemic ECG changes ischemia by electrocardiography ischemia by exercise echocardiography ischemic ECG changes myocardial ischemia by ECG finding new ischemic ECG changes HP:0031595 MIO:01144 P waves are normally upright in leads I and II and inverted in aVR.[url:http://purl.obolibrary.org/obo/HP_0031595] Any anomaly of the P wave of the EKG, which results from atrial depolarization. The P wave occurs when the sinoatrial node creates an action potential that depolarizes the atria. [url:http://purl.obolibrary.org/obo/HP_0031595] abnormal P wave PMID:32032438 PMID:32568742 MIO:01145 According to the following criteria, a “N” wave was considered present in the ECG:1 (a) a notch or deflection in the terminal QRS complex of the surface ECG; (b) the height of notch or deflection of ≥2 mm (the point of deflection was measured with reference to the PR segment); (c) a continuous change of the notch (the point of deflection shifted ≥2 mm with reference to the PR segment, ≥2 leads) in 24 hours, even disappeared or come into the “s” wave (d) with a prolongation of QRS wave duration in these leads. [url:https://pubmed.ncbi.nlm.nih.gov/32032438/] N wave N-wave delayed activation wave MP:0003898 MIO:01146 The ventricles have a large muscle mass compared to the atria and so the QRS complex usually has a much larger amplitude than the P-wave.[url:http://purl.obolibrary.org/obo/MP_0003898] anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction [url:http://purl.obolibrary.org/obo/MP_0003898] abnormal QRS complex HP:0031547 MP:0003899 MIO:01147 anomaly in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave [url:http://purl.obolibrary.org/obo/MP_0003899] abnormal QT interval QT variability HP:0012249 UMLS:C4022993 MIO:01148 An electrocardiographic anomaly of the ST segment, which is the segment that connects the QRS complex and the T wave. The ST segment normally has a duration of 80 to 120 ms, is flat and at the same level (isoelectric) as the PR and TP segment. [url:http://purl.obolibrary.org/obo/HP_0012249] abnormal ST segment ST segment changes ST segment elevation or depression HP:0005135 MIO:01149 abnormal T wave T-wave abnormalities abnormal T-wave MIO:01150 number of electrocardiographic leads involved HP:0012272 MIO:01151 J waves can be seen in hypothermia when the core body temperature falls below 32 degrees C. Then, they occur most prominently in the inferior leads: II, III, and aVF and the precordial leads: V5-V6. J waves can also be observed in other conditions such as some forms of Brugada syndrome.[url:http://purl.obolibrary.org/obo/HP_0012272] The J wave is a positive convex deflection that occurs at the junction of the QRS complex and ST segment, the J-point. [url:http://purl.obolibrary.org/obo/HP_0012272] J wave J waves osborne waves MIO:01152 Late potentials are taken to represent delayed and fragmented depolarisation of the ventricular myocardium, which may be the substrate for a micro-re-entry mechanism, implying a higher risk of potentially dangerous ventricular tachyarrhythmias.[url:https://en.wikipedia.org/wiki/Signal-averaged_electrocardiogram] SAECG recording yields a single, averaged QRS potential, usually printed in a much larger scale than standard ECGs, upon which the SAECG software performs calculations to reveal small variations (typically 1-25 uV) in the final portion of the QRS complex (the so-called "late potentials, or more accurately, "late ventricular potentials"). These can be immediately interpreted by comparing results with cut-off values. [url:https://en.wikipedia.org/wiki/Signal-averaged_electrocardiogram] late potentials LP abnormal signal-averaged ECG abnormal signal-averaged electrocardiogram late ventricular potentials NCIT:C47872 MIO:01153 An electrocardiographic finding of a QS wave, which is atypical. [url:http://purl.obolibrary.org/obo/NCIT_C47872] QS wave QS complex QS complexes QS wave by ECG finding abnormal Q wave PMID:10080460 MIO:01154 exercise-induced ST segment depression ST depression during exercise ST segment depression during exercise ST segment depression in exercise ST segment depression on exercise exercise-induced ST depression exercise-induced STD PMID:1597219 MIO:01155 exercise-induced ST segment elevation ESTE ST elevation during exercise testing ST elevation on exercise ST segment elevation during exercise ST segment elevation during exercise testing ST-elevation in exercise ST-segment elevation during exercise treadmill test exercise induced ST elevation NCIT:C36263 PMID:22279115 MIO:01156 A malignant tumor that has spread from its original (primary) site of growth to another site close to or distant from the primary site. [url:http://purl.obolibrary.org/obo/NCIT_C36263] metastatic malignant neoplasm metastatic cancer MONDO:0007254 MIO:01157 A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males. [url:http://purl.obolibrary.org/obo/MONDO_0007254] breast cancer breast tumor malignant neoplasm of breast malignant tumor of the breast mammary cancer mammary tumor primary breast cancer NCIT:C2955 MIO:01158 A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. [url:http://purl.obolibrary.org/obo/NCIT_C2955] colorectal cancer CRC cancer of large bowel cancer of the large bowel cancer of the large intestine carcinoma of large bowel carcinoma of large intestine carcinoma of the large bowel carcinoma of the large intestine colorectal (colon or rectal) cancer colorectal carcinoma large bowel cancer large bowel carcinoma large intestine cancer large intestine carcinoma HP:0001909 PMID:22279115 SCDO:0000687 MIO:01159 A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [url:http://purl.obolibrary.org/obo/HP_0001909] leukaemia blood cancer NCIT:C3208 PMID:22279115 UMLS:C4227552 MIO:01160 A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas. [url:http://purl.obolibrary.org/obo/NCIT_C3208] lymphoma lymphomatous malignant lymphoma NCIT:C4863 MIO:01161 One of the most common malignant tumors afflicting men. The majority of carcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland. Grossly, prostatic carcinomas appear as ill-defined yellow areas of discoloration in the prostate gland lobes. Adenocarcinomas represent the overwhelming majority of prostatic carcinomas. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic carcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease. [url:http://purl.obolibrary.org/obo/NCIT_C4863] prostate cancer cancer of prostate cancer of the prostate carcinoma of prostate carcinoma of the prostate prostate carcinoma DOID:4159 MIO:01162 An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells. [url:http://purl.obolibrary.org/obo/DOID_4159] skin cancer NCIT:C180553 MIO:01163 A disorder in which there is pathological development of blood clots within the cardiovascular system. [url:http://purl.obolibrary.org/obo/NCIT_C180553] thrombotic disorder thrombotic disease thrombotic events DOID:114 NCIT:C3079 MIO:01164 A cardiovascular system disease that involves the heart. [url:http://purl.obolibrary.org/obo/DOID_114] heart disease cardiac disease cardiac diseases disease of heart disease or disorder of heart disorder of heart heart disease or disorder heart diseases heart disorder heart trouble heart/pericardial disease or disorde unspecified heart problem EFO:0004264 MIO:01165 A non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels. Examples include vasculitis, thrombophlebitis, arteriosclerosis, lymphedema, hemangioma, and angiosarcoma. [url:http://www.ebi.ac.uk/efo/EFO_0004264] vascular disease disease of vasculature disease or disorder of vasculature disorder of blood vessel disorder of vasculature vascular diseases vascular disorder vascular tissue disease vasculature disease vasculature disease or disorder DOID:1575 EFO:0005755 MIO:01166 A musculoskeletal system disease that involves inflammation or pain in the muscles, joints, or fibrous tissue. [url:http://purl.obolibrary.org/obo/DOID_1575] rheumatic disease rheumatic disorder rheumatism rheumatologic disorder NCIT:C2883 PMID:9034940 UMLS:C4014799 MIO:01167 An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain. [url:http://purl.obolibrary.org/obo/NCIT_C2883] arthritis DOID:854 MESH:D003095 NCIT:C27204 SNOMED:268048008 UMLS:C0009326 MIO:01168 A connective tissue disease that characterized by connective tissue disease that has_material_basis in inheritable defects in collagen. [url:http://purl.obolibrary.org/obo/DOID_854] collagen disease collagen vascular disease DOID:8893 MIO:01169 A skin disease that is characterized by patches of thick red skin and silvery scales. [url:http://purl.obolibrary.org/obo/DOID_8893] psoriasis NCIT:C26800 UMLS:C4229471 MIO:01170 Abnormally low levels of thyroid hormone. [url:http://purl.obolibrary.org/obo/NCIT_C26800] hypothyroidism underactive thyroid NCIT:C3123 MIO:01171 Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor. [url:http://purl.obolibrary.org/obo/NCIT_C3123] hyperthyroidism hyperthyroid hyperthyroidism overactive thyroid DOID:5295 NCIT:C26801 MIO:01172 A gastrointestinal system disease that is located in the intestine. [url:http://purl.obolibrary.org/obo/DOID_5295] intestinal disease NCIT:C26781 MIO:01173 A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa. [url:http://purl.obolibrary.org/obo/NCIT_C26781] gastroesophageal reflux disease GERD acid reflux gastroesophageal reflux reflux disease NCIT:C2851 PMID:22279115 UMLS:C0001175 MIO:01174 A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. [url:http://purl.obolibrary.org/obo/NCIT_C2851] acquired immunodeficiency syndrome AIDS HIV / AIDS HIV/AIDS acquired immune deficiency acquired immune deficiency syndrome NCIT:C2902 UMLS:C4229995 MIO:01175 A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood. [url:http://purl.obolibrary.org/obo/NCIT_C2902] coagulation disorder coagulation defect coagulopathy NCIT:C2890 MIO:01176 An acute infectious disorder that is caused by gram positive or gram negative bacteria; representative examples include pneumococcal, streptococcal, salmonella, and meningeal infections. [url:http://purl.obolibrary.org/obo/NCIT_C2890] bacterial infection bacterial disease bacterial disorder HP:0011947 SNOMED:275498002 MIO:01177 An infection of the upper or lower respiratory tract. [url:http://purl.obolibrary.org/obo/HP_0011947] respiratory tract infection respiratory infection respiratory tract infectious disease NCIT:C3364 MIO:01178 The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention.; Disease caused by the spread of bacteria and their toxins in the bloodstream.; A systemic inflammatory response to an infection.; A disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock. [url:http://purl.obolibrary.org/obo/NCIT_C3364] septicemia blood poisoning sepsis systemic sepsis toxemia NCIT:C3439 MIO:01179 Any disease caused by a virus. [url:http://purl.obolibrary.org/obo/NCIT_C3439] viral infection viral disease viral disorder IDO:0000630 MIO:01180 An infection resulting from a transmission process that unfolds in a hospital. [url:http://purl.obolibrary.org/obo/IDO_0000630] hospital-acquired infection NCIT:C3889 MIO:01181 Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection. [url:http://purl.obolibrary.org/obo/NCIT_C3889] pelvic inflammatory disease PID pelvic infection NCIT:C35018 MIO:01182 A state of acute circulatory failure resulting from organ injury or damage in response to infection that results in dangerously low blood pressure. A state of acute circulatory failure characterized by persistent arterial hypotension despite adequate fluid resuscitation or by tissue hypoperfusion unexplained by other causes. [url:http://purl.obolibrary.org/obo/NCIT_C35018] septic shock sepsis-associated hypotension septicaemic shock septicemic shock systemic septic shock NCIT:C78639 MIO:01183 An infectious process affecting a tooth. [url:http://purl.obolibrary.org/obo/NCIT_C78639] tooth infection dental infection dental infections NCIT:C123129 MIO:01184 Contrast-induced nephropathy (CIN) is a form of kidney damage in which there has been recent exposure to medical imaging contrast material without another clear cause for the acute kidney injury. CIN is classically defined as a serum creatinine increase of at least 25% and/or an absolute increase in serum creatinine of 0.5 mg/dL after using iodine contrast agent without another clear cause for acute kidney injury, but other definitions have also been used. [url:https://en.wikipedia.org/wiki/Contrast-induced_nephropathy] contrast-induced nephropathy CIN DOID:1074 DOID:557 MESH:D051437 NCIT:C4376 MIO:01185 A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. [url:http://purl.obolibrary.org/obo/DOID_1074] kidney failure renal failure renal failure syndrome renal insufficiency DOID:576 MIO:01186 A kidney disease that is characterized by the presence of excess proteins in the urine. [url:http://purl.obolibrary.org/obo/DOID_576] proteinuria NCIT:C114592 MIO:01187 Diminished kidney function. An acute or chronic condition where the kidneys are not functioning normally. Contributing Source [url:http://purl.obolibrary.org/obo/NCIT_C114592] renal impairment IRF decreased kidney function: decreased renal function impaired renal function impairment of renal function kidney function decline kidney impairment renal dysfunction worsening renal function NCIT:C26807 MIO:01188 Crystals in the pelvis of the kidney. [url:http://purl.obolibrary.org/obo/NCIT_C26807] renal stone kidney calculus kidney stone renal calculi renal calculus renal stone EFO:0007299 NCIT:C84753 MIO:01189 A disorder caused by hantaviruses of the family Bunyaviridae. It is transmitted by rodents and is manifested with fever, hemorrhage, and renal failure. Other symptoms include headaches, abdominal and back pain, and blurred vision. [url:http://purl.obolibrary.org/obo/NCIT_C84753] hemorrhagic fever with renal syndrome HFRS haemorrhagic fever with renal syndrome hemorrhagic fever, russian hemorrhagic nephrosonephritis puumala virus nephropathy EFO:0009910 NCIT:C98541 MIO:01190 According to the definitions of the American and British Thoracic Societies, including pulmonary functional tests, X-rays, and CT scans for items such as fibrosis, bronchiectasis, bullae, emphysema, nodular or lymphomatous abnormalities. [url:http://www.ebi.ac.uk/efo/EFO_0009910] chronic lung disease chronic lung disorder NCIT:C26872 MIO:01191 The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. [url:http://purl.obolibrary.org/obo/NCIT_C26872] respiratory failure NCIT:C164315 MIO:01192 A category of lung diseases characterized by varying degrees of inflammation and fibrosis of the interstitial lung tissue. Causes include occupational lung exposures and drugs. In a minority of cases there is no clear cause and such cases are termed idiopathic interstitial pneumonia. [url:http://purl.obolibrary.org/obo/NCIT_C164315] interstitial lung disease NCIT:C35772 MIO:01193 A disorder that is caused by the deficiency of a vitamin. The deficiency may result from either suboptimal vitamin intake or conditions that prevent the vitamin's use or absorption in the body. Representative examples include beriberi caused by thiamine deficiency, scurvy caused by vitamin C deficiency, and rickets caused by vitamin D deficiency. [url:http://purl.obolibrary.org/obo/NCIT_C35772] vitamin deficiency disorder avitaminosis vitamin deficiency vitamin deficiency disorder NCIT:C80385 PMID:29083808 UMLS:C4229397 MIO:01194 A lipoprotein metabolism disorder characterized by decreased levels of high-density lipoproteins, or elevated levels of plasma cholesterol, low-density lipoproteins and/or triglycerides. [url:http://purl.obolibrary.org/obo/NCIT_C80385] dyslipidemia dyslipidaemia SNOMED:76314005 MIO:01195 fluid and electrolyte disorders disorder of fluid AND/OR electrolyte fluid and electrolyte disorder water-electrolyte imbalance NCIT:C53655 MIO:01196 A metabolic disorder characterized by abnormal blood glucose levels. [url:http://purl.obolibrary.org/obo/NCIT_C53655] glucose metabolism disorder disorder of glucose metabolism glucose metabolism disorder MIO:01197 hyperoestrogenaemia hyperoestrogenemia NCIT:C84770 MIO:01198 A serious metabolic condition caused by mutations in the MTHFR gene, medications, or nutritional deficiency. It results in increased levels of homocysteine in the blood. Patients with this condition are at an increased risk for recurrent blood clots formation and cardiovascular accidents. [url:http://purl.obolibrary.org/obo/NCIT_C84770] hyperhomocysteinemia DOID:2018 MIO:01199 Abnormally high levels of insulin in the blood. [url:http://purl.obolibrary.org/obo/MONDO_0002177] hyperinsulinism NCIT:C3961 MIO:01200 Abnormally high level of uric acid in the blood. A disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid. A buildup of uric acid (a byproduct of metabolism) in the blood. Hyperuricemia is a side effect of some anticancer drugs. [url:http://purl.obolibrary.org/obo/NCIT_C3961] hyperuricemia MONDO:0000440 NCIT:C28228 MIO:01201 Increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock. [url:http://purl.obolibrary.org/obo/NCIT_C28228] metabolic acidosis acidosis NCIT:C84442 MIO:01202 A combination of medical conditions that when present, increase the risk of heart attack, stroke, and diabetes mellitus. It includes the following medical conditions: increased blood pressure, central obesity, dyslipidemia, impaired glucose tolerance, and insulin resistance. [url:http://purl.obolibrary.org/obo/NCIT_C84442] metabolic syndrome Mets cardiometabolic syndrome metabolic syndrome X EFO:0003839 MIO:01203 Any disease or disorder of the retina. [url:http://www.ebi.ac.uk/efo/EFO_0003839] retinopathy eye disease of retina retina eye disease retinal disease Orphanet:441 MIO:01204 Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension.[Orphanet:441] pure autonomic failure PAF NCIT:C116921 MIO:01205 Diminished mental function. [url:http://purl.obolibrary.org/obo/NCIT_C116921] cognitive impairment NCIT:C4786 PMID:22279115 UMLS:C1969275 MIO:01206 A condition in which a person loses the ability to think, remember, learn, make decisions, and solve problems. Symptoms may also include personality changes and emotional problems. There are many causes of dementia, including Alzheimer disease, brain cancer, and brain injury. Dementia usually gets worse over time. Loss of intellectual abilities interfering with an individual's social and occupational functions. [url:http://purl.obolibrary.org/obo/NCIT_C4786] dementia EFO:0000474 NCIT:C3020 UMLS:C3810329 MIO:01207 A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions. epilepsy epileptic attack epileptic convulsion epileptic convulsions epileptic seizures seizure disorder NCIT:C64329 PMID:22279115 UMLS:C2749590 MIO:01208 Paralysis of one side of the body. [url:http://purl.obolibrary.org/obo/NCIT_C64329] hemiplegia NCIT:C3243 MIO:01209 A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers. [url:http://purl.obolibrary.org/obo/NCIT_C3243] multiple sclerosis DOID:1289 EFO:0005772 MESH:D019636 MONDO:0005559 NCIT:C4802 SNOMED:362975008 UMLS:C1285162 MIO:01210 A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function. [url:http://www.ebi.ac.uk/efo/EFO_0005772] neurodegenerative disease NCIT:C50672 SYMP:0000336 MIO:01211 A finding of pathologic function within the central or peripheral nervous system, secondary to developmental abnormalities, infections, neurologic damage, or tumors. [url:http://purl.obolibrary.org/obo/NCIT_C50672] neurological dysfunction neurological deficit neurological deficit or dysfunction neurological failure MONDO:0043373 MIO:01212 Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning. [url:http://purl.obolibrary.org/obo/MONDO_0043373] sudden sensorineural hearing loss SSHL sudden deafness sudden hearing loss NCIT:C2878 PMID:20031840 UMLS:C0003469 MIO:01213 A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety. [url:http://purl.obolibrary.org/obo/NCIT_C2878] anxiety disorder anxiety disorders NCIT:C92200 PMID:20031840 MIO:01214 A category of psychiatric disorders which have as their most predominant feature a disturbance in mood. [url:http://purl.obolibrary.org/obo/NCIT_C92200] mood disorder emotional disorder psycho-emotional disorder psycho-emotional disorders psychoemotional disorder NCIT:C92201 PMID:20031840 UMLS:C0236988 MIO:01215 A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening. [url:http://purl.obolibrary.org/obo/NCIT_C92201] schizophrenia or other psychotic disorders schizophrenia or other psychotic disorder DOID:303 MESH:D019966 NCIT:C92203 MIO:01216 A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. [url:http://purl.obolibrary.org/obo/DOID_303] substance-related disorder MIO:01217 Psychasthenia was a psychological disorder characterized by phobias, obsessions, compulsions, or excessive anxiety. [url:https://en.wikipedia.org/wiki/Psychasthenia] psychasthenia NCIT:C2981 MIO:01218 A usually reversible condition characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Causes include drug abuse, poisoning, infectious processes, and fluid and electrolyte imbalance. [url:http://purl.obolibrary.org/obo/NCIT_C2981] delirium DOID:0050848 MIO:01219 A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep. [url:http://purl.obolibrary.org/obo/DOID_0050848] obstructive sleep apnea obstructive apnea NCIT:C148023 MIO:01220 A group of breathing disorders characterized by abnormal respiratory patterns or insufficient ventilation during sleep. [url:http://purl.obolibrary.org/obo/NCIT_C148023] sleep-disordered breathing SDB PMID:30956041 SNOMED:119772003 MIO:01221 acute coronary artery closure acute coronary closure ICD11:D53.4 MESH:D017700 PMID:8363430 PMID:9679800 UMLS:C0149649 MIO:01222 A vascular disease that is characterized by blood vessel obstruction resulting from the release of cholesterol from the inside of blood vessels along the bloodstream. [url:http://en.wikipedia.org/wiki/Cholesterol_embolism] cholesterol embolism HP:0002140 PMID:26298362 PMID:30542472 SNOMED:422504002 UMLS:C0948008 MIO:01223 Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured. [url:http://purl.obolibrary.org/obo/HP_0002140] ischemic stroke cerebral ischaemic stroke ischaemic stroke SNOMED:445236007 MIO:01224 A disorder of the heart and kidneys in which dysfunction of one of the organs induces dysfunction of the other organ. [url:http://purl.obolibrary.org/obo/NCIT_C123225] cardiorenal syndrome EFO:0003146 MIO:01225 A heart failure which results in symptoms such as shortness of breath, fatigue, inability to exerciseb& etc [url:http://www.ebi.ac.uk/efo/EFO_0003146] symptomatic heart failure ACC Stage C SNOMED:56675007 MIO:01226 acute heart failure acute HF SNOMED:410431009 MIO:01227 cardiorespiratory failure cardio-respiratory failure ICD11:BD1Z&XT8W PMID:32829713 SNOMED:48447003 MIO:01228 chronic heart failure chronic cardiac failure DOID:6000 ICD11:BD10 MESH:D006333 NCIT:C3080 NCIT:C50577 PMID:22279115 PMID:22537796 PMID:33319509 PMID:34216428 UMLS:C0018801 UMLS:C0018802 UMLS:C3551869 MIO:01229 Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales. [url:http://purl.obolibrary.org/obo/NCIT_C3080] congestive heart failure CHF cardiac failure congestive congestive cardiac failure congestive heart disease congetive cardiac failure SNOMED:446221000 MIO:01230 heart failure with normal ejection fraction HFpEF heart failure with preserved ejection fraction NCIT:C50630 MIO:01231 Failure of adequate output by the left ventricle despite an increase in distending pressure and in end-diastolic volume, with dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema. [url:http://purl.obolibrary.org/obo/NCIT_C50630] left ventricular failure left HF left heart failure left-sided heart failure MONDO:0005253 SNOMED:44088000 MIO:01232 High-output heart failure is a heart condition that occurs when the cardiac output is higher than normal. [url:http://purl.obolibrary.org/obo/MONDO_0005253] low cardiac output syndrome LCOS high output heart failure ICD11:ME24.9 PMID:21532042 PMID:33833517 SNOMED:74474003 UMLS:C0017181 MIO:01233 Gastrointestinal bleeding is a hemorrhagic complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction (STEMI). [url:https://pubmed.ncbi.nlm.nih.gov/21532042/] gastrointestinal bleeding GI haemorrhage GI hemorrhage gastrointestinal bleed gastrointestinal haemorrhage NCIT:C50438 MIO:01234 Bleeding within the cranium. A disorder characterized by bleeding from the cranium. [url:http://purl.obolibrary.org/obo/NCIT_C50438] intracranial hemorrhage HP:0040223 ICD11:MD23 NCIT:C78578 PMID:28154663 PMID:30615768 SNOMED:78144005 MIO:01235 Bleeding from the lung parenchyma. [url:http://purl.obolibrary.org/obo/NCIT_C78578] pulmonary hemorrhage intrapulmonary haemorrhage intrapulmonary hemorrhage pulmonary alveolar hemorrhage pulmonary haemorrhage pulmonary hemorrhage PMID:31217800 SNOMED:451036001 MIO:01236 The manifestations of spinal cord hemorrhage depends on the degree of acuteness and the longitudinal and cross-sectional position of the hematoma. Spinal cord hemorrhage is rare, acute and life-threatening. [url:https://pubmed.ncbi.nlm.nih.gov/31217800/] spinal cord hemorrhage OMIT:0020116 PMID:33381422 SNOMED:304831001 MIO:01237 chronic intracranial subdural hematoma chronic intracranial subdural haematomac chronic subdural hematoma HP:0000225 MSH:D005884 PMID:24808792 PMID:8997108 SNOMED:86276007 MIO:01238 Hemorrhage affecting the gingiva. [url:http://purl.obolibrary.org/obo/HP_0000225] gingival bleeding ICD11:NC51.1Y MIO:01239 hand hematoma hand haematoma PMID:12917730 PMID:26576303 SNOMED:54493002 MIO:01240 Intramural haematoma is defined pathologically as aortic dissection without an intimal tear. [url:https://pubmed.ncbi.nlm.nih.gov/23515169/] intramural hematoma intramural haematoma PMID:19339261 PMID:28895993 PMID:31760241 PMID:33738413 MIO:01241 Intramyocardial dissecting haematoma is a rare complication of myocardial infarction (MI) associated with high mortality rates. [url:https://pubmed.ncbi.nlm.nih.gov/31449618/] intramyocardial dissecting hematoma dissecting intramyocardial hematoma intramyocardial dissecting haematoma intramyocardial haematoma intramyocardial hematoma PMID:3344285 MIO:01242 IMH has been described in areas of microvascular injury caused by erythrocyte extravasation. It is well established that presence of microvascular obstruction confers a worse prognosis. The presence of IMH has been linked to higher concentrations of inflammatory markers and myocardial necrosis and has been linked to adverse left ventricular remodeling. [url:https://pubmed.ncbi.nlm.nih.gov/33442854/] intramyocardial hemorrhage IMH intramyocardial haemorrhage PMID:27751282 MIO:01243 Spontaneous bleed into psoas muscle is a very rare complication of thrombolysis that may require surgical exploration. [url:https://pubmed.ncbi.nlm.nih.gov/27751282/] psoas hematoma spontaneous psoas hematoma PMID:30956041 PMID:9048293 MIO:01244 Retroperitoneal bleeding is an accumulation of blood in the retroperitoneal space. Signs and symptoms may include abdominal or upper leg pain, hematuria, and shock. It can be caused by major trauma or by non-traumatic mechanisms. [url:https://en.wikipedia.org/wiki/Retroperitoneal_bleeding] retroperitoneal bleeding PMID:34317306 MIO:01245 Atraumatic or spontaneous splenic hemorrhage (hematoma and rupture) is a rare condition, often presenting challenges in clinical diagnosis. [url:https://pubmed.ncbi.nlm.nih.gov/34317306/] spontaneous splenic hemorrhage atraumatic splenic hemorrhage PMID:28112701 SNOMED:262797004 MIO:01246 subcapsular liver hematoma subcapsular liver haematoma PMID:9892272 MIO:01247 Subfascial hematoma remains a rare and self-limited complication of thrombolytic therapy. [url:https://pubmed.ncbi.nlm.nih.gov/9892272/] subfascial hematoma DOID:682 ICD11:FB32.2Y MESH:D003161 NCIT:C118422 PMID:15611553 SNOMED:111245009 UMLS:C0009492 MIO:01248 Compartment syndrome is a condition in which increased pressure within one of the body's anatomical compartments results in insufficient blood supply to tissue within that space. There are two main types: acute and chronic. Compartments of the leg or arm are most commonly involved. [url:https://en.wikipedia.org/wiki/Compartment_syndrome] compartment syndrome compartmental syndrome ICD11:BA42 SNOMED:194856005 MIO:01249 Excusions: specified as chronic or with a stated duration of more than 4 weeks (more than 28 days) from onset[url:http://id.who.int/icd/entity/993844371] Infarction of any myocardial site, occurring within 4 weeks (28 days) from onset of a previous infarction. [url:http://id.who.int/icd/entity/993844371] subsequent myocardial infarction extension of myocardial infarction re-infarction reinfarction subsequent MI DOID:0060181 MESH:D017091 PMID:25782050 SNOMED:30588004 UMLS:C0162529 MIO:01250 Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and injury of the large intestine result from inadequate blood supply. Although uncommon in the general population, ischemic colitis occurs with greater frequency in the elderly, and is the most common form of bowel ischemia. [url:https://en.wikipedia.org/wiki/Ischemic_colitis] ischemic colitis ischaemic colitis PMID:29234228 MIO:01251 Purtscher-like retinopathy (PUR) covers a spectrum of conditions with clinical presentation similar to that of Purtscher’s retinopathy, but unlike that which was originally described by Purtscher, they have etiologies that are non-traumatic. [url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717495/] purtscher-like retinopathy DOID:2533 ICD11:3B81.6 MESH:D013159 PMID:17878643 SNOMED:22996003 UMLS:C0037998 MIO:01252 A disease caused by determinants such as trauma, infection, or inherited factors leading to a shortage of oxygen in the spleen. This disease is characterised by death of spleen tissue and loss of function. Confirmation is by medical imaging. [url:http://id.who.int/icd/entity/2072693588] splenic infarction infarction of spleen splenic infarct MP:0002753 MIO:01253 the luminal space of the lower left chamber of the heart is increased in volume or area, usually with an increase in contained fluid [url:http://purl.obolibrary.org/obo/MP_0002753] left ventricular dilation LV dilation LV enlargement dilated heart left ventricle dilated left ventricle left ventricle dilation left ventricular dilatation left ventricular enlargement DOID:1657 GARD:7853 HP:0001629 ICD11:BA60.3 MESH:D006345 NCIT:C84506 OMIM:614429 OMIM:614431 OMIM:614432 ORDO:1480 PMID:34126755 SNOMED:30288003 UMLS:C0018818 MIO:01254 A mechanical rupture of the interventricular septum after S-T elevation myocardial infarction resulting in the left-to-right shunt to deteriorate hemodynamic, which confers a high 30-day mortality. Rupture of the septum with an anterior infarction tends to be apical in location, whereas inferior infarctions are associated with perforation of the basal septum. [url:http://id.who.int/icd/entity/528140652] ventricular septal defect VSD ventricular septal defects NCIT:C50711 MIO:01255 The creation of hematoma outside the arterial wall following bleeding due to puncture of the arterial wall. Pseudoaneurysms can also occur in the heart chambers following myocardial infarction and bleeding. [url:http://purl.obolibrary.org/obo/NCIT_C50711] pseudoaneurysm false aneurysm NCIT:C26693 MIO:01256 Localized dilatation of a blood vessel wall. Bulging or ballooning in an area of an artery secondary to arterial wall weakening. [url:http://purl.obolibrary.org/obo/NCIT_C26693] aneurysm aneurism ICD11:BA60.4 NCIT:C34669 PMID:13365498 PMID:14453446 PMID:22673027 PMID:5697942 PMID:7788773 SNOMED:233847009 MIO:01257 A tearing of acutely infarcted tissue after acute myocardial infarction, which may involve the papillary muscles, interventricular septum, or free wall of either ventricle. [url:http://id.who.int/icd/entity/318811736] cardiac rupture cardiac ruptures heart rupture heart ruptures myocardial rupture PMID:17667459 UMLS:C3640832 MIO:01258 An electrocardiographic finding in leads V1 or V2 of an initial R wave duration greater than or equal to 40 ms, R wave greater than S wave, upright T wave, with accompanying ST elevation, which is suggestive of acute myocardial infarction of the ventricular wall of the left ventricle. Evidence of inferior or lateral myocardial infarction is usually also present. [url:http://purl.obolibrary.org/obo/NCIT_C102594] right ventricular myocardial infarction RVMI right ventricular MI right ventricular infarction right ventricular involvement right ventricular wall myocardial infarction DOID:11502 HP:0001653 ICD11:BB61.Z MESH:D008944 NCIT:C50888 PMID:12436029 SNOMED:48724000 MIO:01259 Dysfunction of the mitral valve characterized by incomplete valve closure. [url:http://purl.obolibrary.org/obo/NCIT_C50888] mitral valve insufficiency mitral incompetence mitral insufficiency mitral valve insufficiency mitral valve insufficiency/ regurgitation ICD11:BE19 NCIT:C99126 PMID:12356339 PMID:12463627 PMID:8721663 SNOMED:253546004 MIO:01260 Dynamic left ventricular outflow tract (LVOT) obstruction was thought to be a hallmark of hypertrophic obstructive cardiomyopathy, especially in those cases with isolated asymmetric septal hypertrophy and systolic anterior motion (SAM) of the mitral valve.[url:https://pubmed.ncbi.nlm.nih.gov/12356339/] Left ventricular outflow tract (LVOT) obstruction can occur at the valvular, subvalvular, or supravalvular level. In general, there is an obstruction to forward flow which increases afterload, and if untreated, can result in hypertrophy, dilatation, and eventual failure of the left ventricle. [url:http://purl.obolibrary.org/obo/HP_0032092] left ventricular outflow tract obstruction dynamic left ventricular outflow tract obstruction HP:0005180 ICD11:BB81.Z PMID:33629006 SNOMED:111287006 UMLS:C0040961 MIO:01261 Failure of the tricuspid valve to close sufficiently upon contraction of the right ventricle, causing blood to regurgitate (flow backward) into the right atrium. [url:http://purl.obolibrary.org/obo/HP_0005180] tricuspid valve insufficiency tricuspid incompetence tricuspid regurgitation tricuspid valve regurgitation EFO:1001461 MIO:01262 In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium (the inner lining of blood vessels) and can be broadly defined as an imbalance between vasodilating and vasoconstricting substances produced by (or acting on) the endothelium. Normal functions of endothelial cells include mediation of coagulation, platelet adhesion, immune function and control of volume and electrolyte content of the intravascular and extravascular spaces. [url:http://www.ebi.ac.uk/efo/EFO_1001461] endothelial dysfunction coronary endothelial dysfunction endothelial damage impaired endothelial function NCIT:C116115 MIO:01263 The formation of a blood clot of a vessel or heart chamber after and due to the placement of a stent. [url:http://purl.obolibrary.org/obo/NCIT_C116115] stent thrombosis ST in-stent thrombosis intrastent thrombus scaffold thrombosis stent thrombus PMID:31544899 MIO:01264 Intracoronary thrombus burden is an important factor affecting the success of the procedure particularly in patients undergoing percutaneous coronary intervention (PCI). According to thrombus grade the patients were grouped as low thrombus burden (grades 0-3) and high thrombus burden (grades 4 and 5). [url:https://pubmed.ncbi.nlm.nih.gov/31544899/] thrombus burden NCIT:C114397 MIO:01265 The formation of a blood clot in the lumen of a vessel; causes include coagulation disorders, and vascular endothelial injury. [url:http://purl.obolibrary.org/obo/NCIT_C114397] vascular thrombosis PMID:12586252 MIO:01266 Angiographic distal embolization was defined as the angiographic cutoff of the distal branch or vessel at any point during the procedure. [url:https://pubmed.ncbi.nlm.nih.gov/12586252/] distal embolization angiographic distal embolization PMID:27824538 SNOMED:765465004 MIO:01267 Left ventricular thrombus (LVT) is a common complication of acute myocardial infarction and is associated with morbidity from embolic complications. [url:https://pubmed.ncbi.nlm.nih.gov/33389609/] left ventricular thrombus LV apical thrombus LVT apical thrombus left ventricular thrombosis ICD11:BA60.7 PMID:7606646 PMID:8821415 SNOMED:51670003 MIO:01268 A blood clot formed on the endoventricle or endoatirium, usually overlying dyskinetic or akinetic area of the ventricular infarction after acute myocardial infarction. [url:http://id.who.int/icd/entity/8597952] mural thrombus mural thrombosis PMID:23386235 MIO:01269 Organized thrombus was defined as having the features of endothelialization and capillary vessel ingrowth with or without smooth muscle cell ingrowth and connective tissue deposition; plaque components as material with any fragment of vessel wall, inflammatory cells, a necrotic core and cholesterol crystals; and calcification as calcium deposition [url:https://pubmed.ncbi.nlm.nih.gov/23386235/] organized thrombus PMID:30571511 MIO:01270 procedure-related thrombosis procedure-related thrombus HP:0005162 MSH:D006333 NCIT:C50629 SNOMED:429589006 UMLS:C0023212 MIO:01271 Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole. [url:http://purl.obolibrary.org/obo/HP_0005162] left ventricular dysfunction LVD abnormal left ventricular function impaired left ventricular function left ventricle dysfunction left ventricular cardiac dysfunction left ventricular impairment poor cardiac function reduced ventricular function worsening of LV function NCIT:C50733 MIO:01272 Impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall. [url:http://purl.obolibrary.org/obo/NCIT_C50733] right ventricular dysfunction RV dysfunction RVD NCIT:C27197 MIO:01273 Acute inflammation of the lung parenchyma caused by viruses, bacteria, fungi, radiation treatment, or exposure to chemicals. Signs and symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness. [url:http://purl.obolibrary.org/obo/NCIT_C27197] acute pneumonia acute pulmonary infection NCIT:C115163 MIO:01274 Pneumonia that is not acquired in a hospital or long-term care facility setting. [url:http://purl.obolibrary.org/obo/NCIT_C115163] community-acquired pneumonia NCIT:C66924 MIO:01275 An event in the personal medical history of coronary artery disease as evidenced by one of the following: 1) prior coronary artery bypass surgery (CABG), 2) prior percutaneous coronary intervention (PCI), 3) angiographically documented coronary artery stenosis greater than or equal to 50 percent 4) angiographically documented coronary atherosclerosis (not greater than 50 percent), 5) a positive stress test, 6) alternatively documented coronary atherosclerosis using other imaging techniques, 7) prior myocardial infarction, or 8) prior angina pectoris. (from NIH Roadmap Cardiovascular Data Standards Working Group) [url:http://purl.obolibrary.org/obo/NCIT_C66924] personal history of coronary artery disease history of coronary artery disease history of coronary heart disease personal history of coronary artery disease previous CAD previous coronary artery disease SNOMED:308064009 MIO:01276 history of cerebrovascular disease previous cerebrovascular disease SNOMED:275538002 MIO:01277 history of anemia history of anaemia SNOMED:312442005 MIO:01278 history of atrial fibrillation NCIT:C66922 MIO:01279 An event in the personal medical history of sustained, inadequate tissue perfusion secondary to cardiac dysfunction, generally defined as systolic blood pressure of less than 90 mm Hg of more than 1 hour and not responsive to fluid resuscitation alone. Associated signs of peripheral hypoperfusion (e.g. cool extremities, oliguria, altered sensorium) or a cardiac index of less than 2.2L/min/m^(2) are present. This clinical entity includes instances in which the systolic blood pressure is raised to 90 mmHg or more using inotropic agents, within the first hour. [url:http://purl.obolibrary.org/obo/NCIT_C66922] history of cardiogenic shock NCIT:C66926 MIO:01280 An event in the personal medical history of heart failure, a condition in which the heart is unable to pump enough blood to meet the body's requirements. [url:http://purl.obolibrary.org/obo/NCIT_C66926] history of heart failure history of congestive heart failure prior heart failure SNOMED:161501007 MIO:01281 history of hypertension MIO:01282 history of hemorrhagic stroke previous hemorrhagic stroke prior hemorrhagic stroke MIO:01283 history of ischemic stroke prior ischemic stroke SNOMED:82581004 MIO:01284 former drinker ex-drinker former alcohol drinker NCIT:C126383 SNOMED:219006 MIO:01285 An individual who drinks at least once per week with regularity. [url:http://purl.obolibrary.org/obo/NCIT_C126383] current drinker alcohol user current alcohol use current drinker of alcohol current drinkers drinks alcohol regular drinker use alcohol NCIT:C66824 MIO:01286 A carbonated alcoholic beverage made through the fermentation of sugars derived from malted grains; this beverage is usually flavored with hops but other herbs or fruit may be used to enhance its flavor. [http://purl.obolibrary.org/obo/NCIT_C66824] beer consumption beer NCIT:C19796 MIO:01287 An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history. [url:http://purl.obolibrary.org/obo/NCIT_C19796] smoking status current tobacco and nicotine consumption status tobacco smoking status SNOMED:365983005 MIO:01288 snuff use NCIT:C164166 MIO:01289 An indication of an individual's current vaping use. [url:http://purl.obolibrary.org/obo/NCIT_C164166] vaping e-cigarette e-cigarette use electronic cigarette electronic cigarrete vaping status GECKO:0000092 SNOMED:161615003 MIO:01290 A clinical history that is about surgical operations performed on an individual. [url:http://purl.obolibrary.org/obo/GECKO_0000092] surgical history history of surgery SNOMED:439631004 MIO:01291 history of statin therapy pre-treatment with statin preinfarct statin use HP:0031659 MIO:01292 S4 occurs in late diastole, is associated with atrial contraction, and coincides with the P wave on the EKG.[url:http://purl.obolibrary.org/obo/HP_0031659] The fourth heart sound (S4) is a low-pitched sound that occurs just before the first heart sound (S1) when the atria contract to force blood into the left ventricle, that is, coincident with late diastolic filling of the ventricle due to atrial contraction. [url:http://purl.obolibrary.org/obo/HP_0031659] fourth heart sound S4 atrial gallop presystolic gallop HP:0001688 ICD11:BC80.1 NCIT:C26923 PMID:30341846 SNOMED:49710005 UMLS:C0085610 MIO:01293 Bradycardia related to a mean resting sinus rate of less than 50 beats per minute. [url:http://purl.obolibrary.org/obo/HP_0001688] sinus bradycardia ICD11:C62242 NCIT:C62242 PMID:914096 MIO:01294 An interruption in the typical sinus cadence where the p-p interval > sum of 2 previous p-p (excludes sinus arrhythmia). [url:http://id.who.int/icd/entity/800198008] sinus pause sinus arrest sinus standstill NCIT:C67106 MIO:01295 Cardiac arrest that is reversed, usually by CPR and/or defibrillation or cardioversion, or cardiac pacing. [url:http://purl.obolibrary.org/obo/NCIT_C67106] resuscitated cardiac arrest event resuscitated cardiac arrest resuscitated cardiac arrest events EFO:0004278 MONDO:0007264 MIO:01296 An unexpected natural death from a cardiac cause within a short time period from the onset of symptoms. [url:http://www.ebi.ac.uk/efo/EFO_0004278] sudden cardiac arrest aborted SCD aborted sudden cardiac death MSH:D054537 SNOMED:233917008 UMLS:C1841659 MIO:01297 Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles. [url:http://purl.obolibrary.org/obo/HP_0001678] atrioventricular block atrioventricular nodal disease interruption of electrical communication between upper and lower chambers of heart MP:0010560 MIO:01298 absent or delayed conduction within the ventricular conducting system or in the ventricular myocardium [ https://www.worldcat.org/search?q=bn%3A0-683-40008-8 ] [url:http://purl.obolibrary.org/obo/MP_0010560] intraventricular block IVB IVCD intraventricular conduction defects HP:0012723 ICD11:BC80.21 MSH:D012848 PMID:15342281 SNOMED:65778007 UMLS:C0037188 MIO:01299 Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria. [url:http://purl.obolibrary.org/obo/HP_0012723] sinoatrial block PMID:27173032 MIO:01300 The expiratory phase was defined as the time interval between 2 threshold values: f1 and f2. For computation of ETA, heartbeat intervals starting between f1 and f2 were identified as anchors. [url:https://pubmed.ncbi.nlm.nih.gov/27173032/] expiration-triggered sinus arrhythmia ETA HP:0011703 MSH:D013616 NCIT:C26889 PMID:30341846 SNOMED:11092001 UMLS:C0039239 MIO:01301 Heart rate of greater than 100 beats per minute. [url:http://purl.obolibrary.org/obo/HP_0011703] sinus tachycardia sinus tach sinus tachy HP:0001692 NCIT:C80503 PMID:1378995 SNOMED:17366009 UMLS:C4025755 MIO:01302 A type of supraventricular tachycardia in which the atria are the principal site of electrophysiologic disturbance. [url:http://purl.obolibrary.org/obo/HP_0001692] atrial arrhythmia atrial arrhythmias primary atrial arrhythmia PMID:3769957 SNOMED:63593006 MIO:01303 supraventricular premature beats premature supraventricular beats supraventricular extrasystoles supraventricular premature contraction HP:0004755 MSH:D013617 NCIT:C35061 PMID:32307093 PMID:868738 SNOMED:6456007 UMLS:C0039240 UMLS:C1698480 MIO:01304 Supraventricular tachycardia (SVT) is an abnormally increased heart rate (over 100 beats per minute at rest) with origin above the level of the ventricles. [url:http://purl.obolibrary.org/obo/HP_0004755] supraventricular tachycardia rapid ventricular rate supraventricular tachyarrhythmia MSH:D018880 PMID:937356 SNOMED:287057009 UMLS:C0033036 MIO:01305 A type of cardiac arrhythmia with premature atrial contractions or beats caused by signals originating from ectopic atrial sites. [url:http://purl.obolibrary.org/obo/HP_0006699] premature atrial contractions PACs atrial ectopic beats atrial premature complex premature atrial contraction HP:0004756 ICD11:BC71.0 NCIT:C50802 PMID:30341846 PMID:31706474 PMID:34191359 SNOMED:25569003 MIO:01306 Ventricular tachycardia is a cardiac arrhythmia of three or more consecutive complexes in duration emanating from the ventricles at a rate of greater than 120 bpm in adolescents or adults and a rate greater than 150 bpm in child. Ventricular tachycardia may occur with or without loss of cardiac output.[url:http://id.who.int/icd/entity/1171837620] Ventricular tachycardia (VT) is a potentially life-threatening ventricular arrhythmia that presents as a wide QRS complex tachycardia, and is defined as three or more consecutive QRS complexes with a duration longer than 120 milliseconds (ms) and a rate of 100 beats per minute or more, whereby the complexes have a ventricular origin. VT can be subdivided as follows: (i) sustained VT persists for 30 seconds or more; (ii) non-sustained VT lasts less than 30 seconds; (iii) monomorphic VT displays a uniform QRS morphology; and (iv) polymorphic VT displays QRS morphologies that variy from beat to beat. VT is observed most commonly in individuals with structural heart disease or acute myocardial infarction (MI). VT may also be observed in in the setting of drug toxicity or electrolyte abnormalities or in individuals with Mendelian disease. [url:http://purl.obolibrary.org/obo/HP_0004756] ventricular tachycardia ventricular tachyarrhythmia ventricular tachyarrhythmias HP:0001663 ICD11:BC71.1 NCIT:C50799 PMID:32838731 PMID:33990895 PMID:3965958 SNOMED:71908006 MIO:01307 Ventricular fibrillation is a rapid grossly irregular ventricular rhythm, usually more than 300 bpm/200 ms (cycle length 180 ms or less), with marked variability in QRS cycle length, morphology, and amplitude, associated with loss of cardiac output, and is usually sustained, requiring intervention to terminate.[url:http://id.who.int/icd/entity/1662472992] Uncontrolled contractions of muscles fibers in the left ventricle not producing contraction of the left ventricle. Ventricular fibrillation usually begins with a ventricular premature contraction and a short run of rapid ventricular tachycardia degenerating into uncoordinating ventricular fibrillations. [url:http://purl.obolibrary.org/obo/HP_0001663] ventricular fibrillation VF HP:0006682 MIO:01308 Premature ventricular contractions (PVC) or ventricular extrasystoles are premature contractions of the heart that arise in response to an impulse in the ventricles rather than the normal impulse from the sinoatrial (SA) node. [url:http://purl.obolibrary.org/obo/HP_0006682] premature ventricular contraction VPC extra heart beat premature ventricular beat premature ventricular contractions ventricular ectopic activity ventricular ectopic beat ventricular ectopic beats ventricular ectopics ventricular extrasystoles ventricular premature beat ventricular premature beats PMID:30807351 MIO:01309 radiation chest pain radiation pain MIO:01310 A time measurement datum that measures the duration of having chest pain. duration of chest pain chest pain duration SNOMED:102587001 MIO:01311 acute chest pain PMID:20819565 MIO:01312 central chest pain SNOMED:225566008 MIO:01313 ischemic chest pain Ischaemic chest pain PMID:20819565 MIO:01314 left chest pain left side chest pain HP:0032141 ICD11:MC86 SNOMED:71884009 MIO:01315 A type of chest pain that arises in the or under the left breast and often described as throbbing, stabbing, or burning, and lasting hours or longer. The pain may arise with or after effort, and may spread to the left arm or left side of the neck. [url:http://purl.obolibrary.org/obo/HP_0032141] precordial pain NCIT:C168501 MIO:01316 The sensation of chest pain described as an object creating physical force. [url:http://purl.obolibrary.org/obo/NCIT_C168501] pressure chest pain chest pressure pressure pain MIO:01317 right chest pain right side chest pain HP:0012764 MIO:01318 A sensation of breathlessness in the recumbent position, relieved by sitting or standing. [ UToronto:htrang ] [url:http://purl.obolibrary.org/obo/HP_0012764] orthopnea MIO:01319 physiological biomarker physiological biomarkers physiological marker physiological markers EFO:0008471 MIO:01320 cardiac stress biomarker MIO:01321 coagulation and fibrinolysis biomarker coagulation biomarker fibrinolysis biomarker OPMI:0000457 MIO:01322 A biomarker that can serve a role in narrowing down diagnosis, which can lead to diagnosis that is significantly more specific to individual patients. [url:http://purl.obolibrary.org/obo/OPMI_0000457] diagnostic biomarker diagnostic biomarkers diagnostic marker diagnostic markers OPMI:0000454 MIO:01323 imaging biomarker imaging biomarkers imaging marker imaging markers EFO:0004872 MIO:01324 Is a quantification of any molecule involved in the process of inflammatory response. [url:http://www.ebi.ac.uk/efo/EFO_0004872] inflammatory biomarker inflammatory biomarkers OPMI:0000452 MIO:01325 molecular biomarker molecular biomarkers molecular marker molecular markers OPMI:0000456 MIO:01326 A biomarker that provides information about the patient's overall outcome, regardless of therapy. [url:http://purl.obolibrary.org/obo/OPMI_0000456] prognostic biomarker prognostic biomarkers prognostic marker prognostic markers PMID:31127678 MIO:01327 ‘wet-warm’ – patients demonstrating congestion and adequate peripheral perfusion [url:https://pubmed.ncbi.nlm.nih.gov/31127678/] forrester class 1 forrester grade 1 PMID:31127678 MIO:01328 ‘wet-cold’ – with congestion and hypoperfusion [url:https://pubmed.ncbi.nlm.nih.gov/31127678/] forrester class 2 forrester grade 2 PMID:31127678 MIO:01329 ‘dry-cold’ – free of congestion but with hypoperfusion [url:https://pubmed.ncbi.nlm.nih.gov/31127678/] forrester class 3 forrester grade 3 PMID:31127678 MIO:01330 ‘dry-warm’ – free of either congestion or hypoperfusion [url:https://pubmed.ncbi.nlm.nih.gov/31127678/] forrester class 4 forrester grade 4 MIO:01331 Killip class I-II MIO:01332 Killip class II-IV High Killip class over II Killip class > 1 Killip class > or = 2 Killip class >/= 2 Killip class over II Killip class>/=2 Killip classification 2-4 Killip grade >/=2 Killip's class > or =II NCIT:C66904 MIO:01333 A finding associated with a patient with defined or presumed cardiac disease without limitations of physical activity. Ordinary physical activity does not cause undue fatigue, palpitation, or dyspnea. (from The Criteria Committee of the New York Heart Association. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed. Boston, Mass: Little, Brown & Co; 1994:253-256.) [url:http://purl.obolibrary.org/obo/NCIT_C66904] New York Heart Association class I NYHA class 1 NYHA class I NCIT:C66905 MIO:01334 A finding associated with a patient with defined or presumed cardiac disease with slight limitation of physical activity. They are comfortable at rest. Ordinary physical activity results in fatigue, palpitation, or dyspnea. (from The Criteria Committee of the New York Heart Association. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed. Boston, Mass: Little, Brown & Co; 1994:253-256.) [ NCI ]v [url:http://purl.obolibrary.org/obo/NCIT_C66905] New York Heart Association class II NYHA class 2 NYHA class II NCIT:C66907 MIO:01335 A finding associated with a patient with defined or presumed cardiac disease with marked limitation of physical activity. They are comfortable at rest. Less than ordinary activity causes fatigue, palpitation, or dyspnea. (from The Criteria Committee of the New York Heart Association. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed. Boston, Mass: Little, Brown & Co; 1994:253-256.) [url:http://purl.obolibrary.org/obo/NCIT_C66907] New York Heart Association class III NYHA class 3 NYHA class III NCIT:C66908 MIO:01336 A finding associated with a patient with defined or presumed cardiac disease with inability to carry on any physical activity without discomfort. Symptoms are present even at rest or minimal exertion. (from The Criteria Committee of the New York Heart Association. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed. Boston, Mass: Little, Brown & Co; 1994:253-256.) [url:http://purl.obolibrary.org/obo/NCIT_C66908] New York Heart Association class IV NYHA class 4 NYHA class IV CMO:0001997 MIO:01337 Measurement of the physical form or structure of one or more blood vessels, the network of muscular tubes that carry blood through the body. [url:http://purl.obolibrary.org/obo/CMO_0001997] blood vessel morphological measurement blood vessel morphology vascular morphology CMO:0000220 MIO:01338 Resistance to blood flow by blood vessels throughout the body, the degree to which the blood vessels impede the flow of blood, often calculated as SVR equal to the difference between mean arterial blood pressure(MAP) and central venous pressure(CVP) divided by cardiac output(CO). [url:http://purl.obolibrary.org/obo/CMO_0000220] systemic vascular resistance SVR TPR systemic vascular resistances total peripheral resistance SNOMED:364080001 MIO:01339 feature of left ventricle CMO:0002502 MIO:01340 Any measurement of the movement of blood into, through or out of the heart. [url:http://purl.obolibrary.org/obo/CMO_0002502] heart blood flow measurement EFO:0004311 MIO:01341 A heart function measurement is a measurement of some heart function or process typically used to establish normal heart function or in process of diagnosis. [url:http://www.ebi.ac.uk/efo/EFO_0004311] heart function measurement cardiac function study cardiac function tests heart function tests CMO:0001544 MIO:01342 Any measurement of the thick contractile middle layer of uniquely constructed and arranged muscle cells that forms the bulk of the heart wall. [url:http://purl.obolibrary.org/obo/CMO_0001544] myocardium measurement myocardium feature NCIT:C20080 MIO:01343 The X-ray examination of the blood vessels or chambers of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C20080] angiography NCIT:C38103 MIO:01344 An x-ray of the structures inside the chest. An x-ray is a type of high-energy radiation that can go through the body and onto film, making pictures of areas inside the chest, which can be used to diagnose disease. [url:http://purl.obolibrary.org/obo/NCIT_C38103] chest radiography CXR chest X-ray NCIT:C17203 MIO:01345 A type of tomography in which gamma photon-emitting radionuclides are administered to the patient and then detected by one or more gamma cameras rotated around the patient. From the series of two-dimensional images produced, a three-dimensional image can be created by computer reconstruction. [url:http://purl.obolibrary.org/obo/NCIT_C17203] single photon emission computed tomography SPECT SPECT imaging SPECT scan SPET single photon emission tomography single-photon emission computed tomography NCIT:C168175 MIO:01346 A noninvasive medical imaging technology that uses x-ray procedure with the aid of computer to generate cross-sectional images of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C168175] computed tomography of the heart cardiac CT cardiac computed tomography heart CT NCIT:C137805 MIO:01347 Computed tomography that uses a contrast agent to visualize anatomic structures. [url:http://purl.obolibrary.org/obo/NCIT_C137805] computed tomography with contrast CT scan with contrast CT with contrast contrast enhanced computed tomography contrast-enhanced computed tomography NCIT:C157337 MIO:01348 A type of computed tomography that uses a two-dimensional detector array, allowing for the acquisition of multiple slices simultaneously. This results in an increase in imaging acquisition speed, more coverage of the patient, and high spatial resolution. MDCT acquires volume data instead of individual slice data. [url:http://purl.obolibrary.org/obo/NCIT_C157337] multi-detector computed tomography MDCT multidetector CT multidetector computed tomography NCIT:C137915 MIO:01349 A noninvasive medical imaging technology using magnetic field and radio waves to evaluate the heart's anatomy and function for detection and monitoring of cardiac diseases. [url:http://purl.obolibrary.org/obo/NCIT_C137915] cardiac magnetic resonance imaging CMR cardiac MRI cardiac magnetic resonance cardiovascular MRI cardiovascular magnetic resonance heart MRI magnetic resonance imaging of the heart NCIT:C103400 MIO:01350 An imaging technique that utilizes positron emission tomography to produce a three-dimensional image of functional processes in the body. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on the biologically active molecule (fludeoxyglucose) FDG. FDG is an analogue of glucose which when imaged will give tissue metabolic activity, in terms of regional glucose uptake. [url:http://purl.obolibrary.org/obo/NCIT_C103400] FDG-positron emission tomography FDG-PET FDG-PET imaging fluorine-18 fluorodeoxyglucose positron emission tomography SNOMED:764709003 MIO:01351 positron emission tomography using methionine C-11 C-11 acetate positron emission tomography C-11 choline positron emission tomography PET using methionine C-11 OMIT:0012805 MIO:01352 Radionuclide angiography is an area of nuclear medicine which specialises in imaging to show the functionality of the right and left ventricles of the heart, thus allowing informed diagnostic intervention in heart failure. It involves use of a radiopharmaceutical, injected into a patient, and a gamma camera for acquisition. [url:https://en.wikipedia.org/wiki/Radionuclide_angiography] radionuclide angiography radionuclide angiocardiography SNOMED:764840003 MIO:01353 Technique for the combined evaluation of myocardial perfusion and left ventricular function within a single procedure. [url:http://snomed.info/id/764840003] 99mTc-sestamibi single photon emission computed tomography 99Tcm-sestamibi SPECT 99Tcm-sestamibi single-photon emission computed tomography Tc-99m-MIBI single photon emission computed tomography dipyridamole (99m) Tc-sestamibi single-photon emission computed tomography dipyridamole (99m)Tc-sestamibi single photon emission computed tomographic imaging gated single photon emission computed tomography of myocardium using technetium (99m-Tc) sestamibi single photon emission computed tomography with technetium-99m hexakis 2-methoxyisobutyl isonitrile technetium-99m hexakis 2-methoxyisobutyl isonitrile single photon emission computed tomography NCIT:C102676 UMLS:C2350390 MIO:01354 A procedure that captures pictures of blood flow throughout the heart muscle. [url:http://purl.obolibrary.org/obo/NCIT_C102676] myocardial perfusion imaging myocardial perfusion scan radionuclide myocardial perfusion study NCIT:C38058 UMLS:C1455714 MIO:01355 A nuclear imaging procedure, using the radionuclide Thallium, that shows whether the heart muscle is receiving adequate blood supply under stress and/or rest conditions. [url:http://purl.obolibrary.org/obo/NCIT_C38058] thallium myocardial perfusion imaging stress test exercise thallium stress thallium test thallium stress test NCIT:C16525 MIO:01356 A test that uses high-frequency sound waves (ultrasound) to create an image of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C16525] echocardiography ECHO_TEST echocardiogram NCIT:C99535 MIO:01357 An invasive procedure in which sound waves (called ultrasound) are bounced off of vascular tissues from within the vessel and the echoes produce a picture (sonogram). [url:http://purl.obolibrary.org/obo/NCIT_C99535] intravascular ultrasound IVUS NCIT:C17241 UMLS:C0042014 MIO:01358 Laboratory analysis of urine, commonly used to aid in the diagnosis of disease or to detect the presence of a specific substance. It involves examination of the urine by physical or chemical means as well as microscopic examination that helps to screen for urinary tract infections, renal disease, and diseases of other organs, that result in abnormal metabolites (break-down products) appearing in the urine. [url:http://purl.obolibrary.org/obo/NCIT_C17241] urinalysis NCIT:C47868 UMLS:C1706969 MIO:01359 A procedure in which a sample of blood is examined to measure the amounts of certain substances made in the body. An abnormal amount of a substance can be a sign of disease in the organ or tissue that produces it. [url:http://purl.obolibrary.org/obo/NCIT_C47868] blood chemistry measurement blood chemistry evaluation blood chemistry study blood chemistry test NCIT:C74971 MIO:01360 A laboratory procedure that tests the function of an endocrine organ and measures the amount of a hormone present in a sample. [http://purl.obolibrary.org/obo/NCIT_C74971] endocrine test NCIT:C64430 UMLS:C1882496 MIO:01361 A term that refers to a chemistry test measuring a specific protein or enzyme in the peripheral blood or body fluid. [url:http://purl.obolibrary.org/obo/NCIT_C64430] protein or enzyme type measurement NCIT:C28133 UMLS:C0005771 MIO:01362 The determination of the number of red blood cells, white blood cells, and platelets in a biospecimen. [url:http://purl.obolibrary.org/obo/NCIT_C28133] blood cell count CBC FBC complete blood count full blood count EFO:0004301 MIO:01363 The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA. [url:http://purl.obolibrary.org/obo/EFO_0004301] blood viscosity GO:0007596 NCIT:C62662 UMLS:C0005790 MIO:01364 The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [url:http://purl.obolibrary.org/obo/GO_0007596] coagulation study blood coagulation NCIT:C16676 NCIT:C64848 MIO:01365 The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb. The substance inside red blood cells that binds to oxygen in the lungs and carries it to the tissues. [url:http://purl.obolibrary.org/obo/NCIT_C16676] hemoglobin HGB Hb haemoglobin MIO:01366 platelet measurement platelet SNOMED:56027003 MIO:01367 Thromboelastography (TEG) is a method of testing the efficiency of blood coagulation. It is a test mainly used in surgery and anesthesiology, although increasingly used in resuscitations in Emergency Departments, intensive care units, and labor and delivery suites. More common tests of blood coagulation include prothrombin time (PT) and partial thromboplastin time (aPTT) which measure coagulation factor function, but TEG also can assess platelet function, clot strength, and fibrinolysis which these other tests cannot. [url:https://en.wikipedia.org/wiki/Thromboelastography] thromboelastography TEG NCIT:C16295 MIO:01368 A type of protein made by B lymphocytes in response to a foreign substance (antigen). Each antibody only binds to a specific antigen, helping to destroy the antigen directly or by assisting white blood cells to destroy the antigen. [url:http://purl.obolibrary.org/obo/NCIT_C16295] antibody Ab antibodies NCIT:C268 SNOMED:7120007 MIO:01369 Any substance, generally a protein, that stimulates the immune system and elicits an immune response. Recognition by the immune system elicits either a T-lymphocyte response, recognizing processed antigens, or a B-lymphocyte response, producing antibodies that bind to unprocessed antigens. [url:http://purl.obolibrary.org/obo/NCIT_C268] antigen antigen antigens NCIT:C21523 MIO:01370 Any of the serum proteins that interact with antigen antibody complex to produce cytolytic, chemotaxic, anaphylactic, and other effects. (from CSP2000) [url:http://purl.obolibrary.org/obo/NCIT_C21523] complement component protein complement complement protein NCIT:C174446 MIO:01371 A measurement of the temperature of the body. [url:http://purl.obolibrary.org/obo/NCIT_C174446] body temperature TEMP temperature OGG:0000000033 MIO:01372 a RNA gene that encodes for a ncRNA [url:http://purl.obolibrary.org/obo/OGG_0000000033] ncRNA gene non-protein coding RNA (ncRNA) gene OGG:0000000039 MIO:01373 a gene that encodes for a protein [url:http://purl.obolibrary.org/obo/OGG_0000000039] protein-coding gene protein coding gene OGG:0000000040 MIO:01374 a gene that has lost its protein-coding ability or is otherwise no longer expressed in the cell. [url:http://purl.obolibrary.org/obo/OGG_0000000040] pseudo gene pseudogene GSSO:010092 MIO:01375 A variation in chromosome structure or number. [url:http://purl.obolibrary.org/obo/GSSO_010092] chromosome variation chromosomal variant chromosomal variation chromosome variant NCIT:C63547 MIO:01376 A way of denoting the collective genotype of a number of closely linked loci on a chromosome. [url:http://purl.obolibrary.org/obo/NCIT_C63547] haplotype haplo NCIT:C99752 SO:1000032 MIO:01377 A sequence alteration which included an insertion and a deletion, affecting 2 or more bases. [http://purl.obolibrary.org/obo/SO_1000032] indel mutation deletion-insertion delins indel indel mutation indel variant indel_variant insertion and deletion insertion-deletion insertion-deletion mutation insertion/deletion MIO:01378 Gene variations other than chromosomal variations, copy number variations, indel mutations and sing-nucleotide variations. other genetic variations GSSO:010090 MIO:01379 A variation of a single nucleotide at a specific location of the genome due to base substitution, which is found at any frequency in the population. [url:http://purl.obolibrary.org/obo/GSSO_010090] single-nucleotide variation SNV single nucleotide variation single-nucleotide variant single-nucleotide variants NCIT:C64840 MIO:01380 An alkaline earth metal, Magnesium is important for many biochemical functions and reactions; for bone and muscle function, protein and fatty acid formation, activation of B vitamins, blood clotting, insulin secretion, and ATP formation. More than 300 enzymes require magnesium for catalytic action. [url:http://purl.obolibrary.org/obo/NCIT_C29239] magnesium Mg NCIT:C331 MIO:01381 A mineral needed for healthy teeth, bones, and other body tissues. It is the most common mineral in the body. A deposit of calcium in body tissues, such as breast tissue, may be a sign of disease.[url:http://purl.obolibrary.org/obo/NCIT_C331] calcium Ca NCIT:C830 MIO:01382 An element with atomic symbol Na, atomic number 11, and atomic weight 23. [url:http://purl.obolibrary.org/obo/NCIT_C830] sodium Na sodium (NOS) NCIT:C2299 MIO:01383 A hormone made mainly in the testes (part of the male reproductive system). It is needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth. Testosterone may also be made in the laboratory and is used to treat certain medical conditions.[url:http://purl.obolibrary.org/obo/NCIT_C2299] testosterone (17Beta)-17-hydroxyandrost-4-en-3-one Delta4-androsten-17beta-ol-3-one Trans-Testosterone CHEBI:29256 MIO:01384 An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety. [url:http://purl.obolibrary.org/obo/CHEBI_29256] thiol thiols NCIT:C64853 NCIT:C765 MIO:01385 A metallic element that is important in body functions such as regulation of blood pressure and of water content in cells, transmission of nerve impulses, digestion, muscle contraction, and heartbeat. [url:http://purl.obolibrary.org/obo/NCIT_C765] potassium K NCIT:C2303 NCIT:C74747 UMLS:C0428419 MIO:01386 A thyroid hormone containing 3 iodine atoms generally synthesized from levothyroxine, and has greater biological activity. [url:http://purl.obolibrary.org/obo/NCIT_C2303] triiodothyronine 3,3',5-triiodo-L-thyronine Liothyronine T-3 T3 TT3 total T3 CHEBI:17775 CHEBI:27226 CHEBI:46823 NCIT:C62652 UMLS:C0041980 MIO:01387 A waste product left over from normal chemical processes in the body and found in the urine and blood. Abnormal buildup of uric acid in the body may cause a condition called gout. Increased levels of uric acid in the blood and urine can be a side effect of chemotherapy or radiation therapy. [url:http://purl.obolibrary.org/obo/NCIT_C62652] uric acid 1H-Purine-2,6,8-triol 2,6,8-Trihydroxypurine 2,6,8-Trioxopurine 2,6,8-Trioxypurine 7,9-Dihydro-1H-purine-2,6,8(3H)-trione UA NCIT:C84818 XCO:0000543 MIO:01388 An experimental condition in which the main influencing factor is one or more closely related forms (vitamers) of vitamin D, a group of fat-soluble secosteroid vitamins (when ingested from dietary sources) and/or hormones (when produced by the skin in response to ultraviolet radiation). Vitamin D is involved in intestinal absorption of calcium, magnesium and phosphate, and in calcium homeostasis and metabolism. [url:http://purl.obolibrary.org/obo/XCO_0000543] vitamin D D vitamin VitD vitamin-D NCIT:C94312 MIO:01389 Impaired glucose metabolism is also associated with heart failure and is a predictor of poor outcome in patients with acute MI (AMI). Glucose present in circulating blood. [url:http://purl.obolibrary.org/obo/NCIT_C94312] blood glucose GLUC blood sugar glucose glycaemia glycemia plasma glucose serum glucose MMO:0000253 NCIT:C61019 MIO:01390 A test which measures the amount of nitrogen present in the blood in the form of urea, the chief nitrogenous end product of protein metabolism. Urea is formed in the liver from amino acids and from ammonia compounds and is found in urine, blood, and lymph. [url:http://purl.obolibrary.org/obo/MMO_0000253] blood urea nitrogen BUN NCIT:C399 NCIT:C64547 MIO:01391 The breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function. [url:http://purl.obolibrary.org/obo/NCIT_C399] creatinine CREAT Cr NCIT:C74949 MIO:01392 A quantitative measurement of the amount of lipids (cholesterol, lipoproteins, and triglycerides) present in a sample. [url:http://purl.obolibrary.org/obo/NCIT_C74949] lipid lipid measurement lipids total Lipid NCIT:C73539 MIO:01393 Any derivatives of amino acids that containing amino (-NH2) and carboxyl (-COOH) groups. [url:http://purl.obolibrary.org/obo/NCIT_C73539] amino acid derivative amino acid derivatives NCIT:C1016 MIO:01394 A naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene inhibits free-radical damage to DNA. This agent also induces cell differentiation and apoptosis of some tumor cell types, particularly in early stages of tumorigenesis, and enhances immune system activity by stimulating the release of natural killer cells, lymphocytes, and monocytes. (NCI04) [url:http://purl.obolibrary.org/obo/NCIT_C1016] beta-carotene .beta.-Carotene 3,7,12,16-tetramethyl-1,18-bis(2,6,6-trimethyl-1-cyclohexenyl)-octadeca-1,3,5,7,9,11,13,15,17-nonaene beta carotene beta-carotene lumitene solatene NCIT:C68306 MIO:01395 Carotenoid having a chemical structure similar to beta-carotene with addition of a hydroxyl group at the number 3 carbon atom. [url:http://purl.obolibrary.org/obo/NCIT_C68306] beta-cryptoxanthin 3,5,5-trimethyl-4-[3,7,12,16-tetramethyl-18-(2,6,6-trimethyl-1-cyclohexenyl) octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-cyclohex-3-en-1-ol NCIT:C2290 MIO:01396 A hormone made by the adrenal cortex (the outer layer of the adrenal gland). It helps the body use glucose (a sugar), protein, and fats. Cortisol made in the laboratory is called hydrocortisone. It is used to treat many conditions, including inflammation, allergies, and some cancers. Cortisol is a type of glucocorticoid hormone. [url:http://purl.obolibrary.org/obo/NCIT_C2290] cortisol 11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione hydrocortisone NCIT:C82621 PMID:33620437 PR:000050369 UMLS:C2826333 MIO:01397 A protein-containing complex that is the remnant of fibrin mesh degradation (fibrinolysis) by plasmin in human. [url:http://purl.obolibrary.org/obo/PR_000050369] D-dimer DDIMER NCIT:C107563 PMID:33620437 UMLS:C0060327 MIO:01398 Derivatives of thrombin-cleaved fibrinogen that are plasma soluble due to limiting amounts of the clot promoting protein factor XIII. Detection of these proteins may be used to aid in the diagnosis or exclusion of thrombotic events or determine if a patient is at risk for post-operative hemorrhage. [url:http://purl.obolibrary.org/obo/NCIT_C107563] fibrin monomer fibrin monomer complex soluble fibrin monomer SNOMED:16670003 MIO:01399 fibrinopeptide B-beta 1-42 B-beta 1-42 MIO:01400 fibrinopeptide B-beta 30-43 NCIT:C1444 MIO:01401 A cofactor for 1-carbon transfer involved with DNA synthesis. [url:http://purl.obolibrary.org/obo/NCIT_C1444] folate 2-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid vitamin B-11 NCIT:C2267 MIO:01402 A hormone involved in sleep regulatory activity, and a tryptophan-derived neurotransmitter, which inhibits the synthesis and secretion of other neurotransmitters such as dopamine and GABA. Melatonin is synthesized from serotonin intermediate in the pineal gland and the retina where the enzyme 5-hydroxyindole-O-methyltransferase, that catalyzes the last step of synthesis, is found. This hormone binds to and activates melatonin receptors and is involved in regulating the sleep and wake cycles. In addition, melatonin possesses antioxidative and immunoregulatory properties via regulating other neurotransmitters. [url:http://purl.obolibrary.org/obo/NCIT_C2267] melatonin 5-Methoxy-N-acetyltryptamine N-Acetyl-5-methoxytryptamine N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide N-[2-(5-methoxyindol-3-yl)ethyl]acetamide MIO:01403 Heparin is a highly acidic heterogeneous mucopolysaccharide consisting of a variably sulfated repeating disaccharide unit. The most common repeating unit is a trisulfated disaccharide composed of a 2-O-sulfated iduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S). Heparin is formed from equal parts sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lungs, and mast cells of vertebrates. Its function is unknown, but it is used to prevent blood clotting, in vivo and in vitro, in the form of many different salts. [url:https://hmdb.ca/metabolites/HMDB0001394] endogenous heparin heparin NCIT:C598 MIO:01404 An important mineral the body needs to make hemoglobin, a substance in the blood that carries oxygen from the lungs to tissues throughout the body. Iron is also an important part of many other proteins and enzymes needed by the body for normal growth and development. It is found in red meat, fish, poultry, lentils, beans, and foods with iron added, such as cereal. [url:http://purl.obolibrary.org/obo/NCIT_C598] iron Fe Niferex NCIT:C94711 MIO:01405 An organic compound with the formula CH2(CHO)2, and a byproduct of lipid metabolism in the body. Malondialdehyde, a highly reactive compound, is one of the many reactive electrophile species that cause toxic stress in cells and form covalent protein adducts, called advanced lipoxidation end products (ALE). This compound also forms mutagenic DNA adducts when it reacts with deoxyadenosine and deoxyguanosine in DNA. Malondialdehyde is also found in many foods and is present in high levels in rancid foods. [url:http://purl.obolibrary.org/obo/NCIT_C94711] malondialdehyde 1,3-Propanedial 1,3-Propanedione 1,3-propanedialdehyde Malonaldehyde Malondialdehyde malonic aldehyde malonicdialdehyde NCIT:C66842 MIO:01406 A naturally occurring trace metalloid element and known neurotoxin with atomic symbol Hg, atomic number 80, and atomic weight 200.59. Mercury has been used in manufacturing, as well as in dental and medical equipment, fertilizers, and pesticides. It is characterized as a heavy, silvery-white metallic liquid at room temperature that is odorless. Exposure occurs by inhalation of fumes, ingestion, or contact. [url:http://purl.obolibrary.org/obo/NCIT_C66842] mercury Hg hydrargyrum liquid silver quicksilver NCIT:C29600 MIO:01407 One of nine essential amino acids in humans (provided by food), Methionine is required for growth and tissue repair. A sulphur-containing amino acid, methionine improves the tone and pliability of skin, hair, and strengthens nails. Involved in many detoxifying processes, sulphur provided by methionine protects cells from pollutants, slows cell aging, and is essential for absorption and bio-availability of selenium and zinc. Methionine chelates heavy metals, such as lead and mercury, aiding their excretion. It also acts as a lipotropic agent and prevents excess fat buildup in the liver. (NCI04) [url:http://purl.obolibrary.org/obo/NCIT_C29600] methionine (S)-2-Amino-4-(methyl-sulfanyl)butanoic acid L-Methionine Met methionine NCIT:C129010 MIO:01408 A pteridine that is a metabolite of guanine triphosphate (GTP) and a precursor for biopterin. Neopterin is released from interferon-gamma (IFNg) stimulated macrophages and dendritic cells (DCs); therefore, urine or serum levels may be used as a marker of immune system activation. [url:http://purl.obolibrary.org/obo/NCIT_C129010] neopterin 2-Amino-6-(1,2,3-Trihydroxypropyl)-4(3H)-Pteridinone 4(1H)-Pteridinone, 2-Amino-6-(1,2,3-Trihydroxypropyl)- NCIT:C695 MIO:01409 An unstable free-radical gas which reacts rapidly with oxygen to form nitrogen oxides. Water soluble, NO is produced normally in numerous tissues and is considered to be a mediator of cell-to cell communication; it functions in numerous processes including vasodilation, inflammation, and neurotransmission. (NCI04) [url:http://purl.obolibrary.org/obo/NCIT_C695] nitric oxide EDRF Inomax Mononitrogen Monoxide Nitrogen Monoxide endothelium-derived relaxing factor OMIT:0013441 MIO:01410 An element of the rare earth family of metals. It has the atomic symbol Sc, atomic number 21, and atomic weight 45. [url:http://purl.bioontology.org/ontology/MESH/D012538] scandium CHEBI:34093 MIO:01411 1-Hydroxypyrene is a human metabolite. It can be found in urine of outdoor workers exposed to air pollution. [url:https://en.wikipedia.org/wiki/1-Hydroxypyrene] 1-hydroxypyrene CHEBI:40304 MIO:01412 Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.[url:http://purl.obolibrary.org/obo/CHEBI_40304] 8-hydroxy-2'-deoxyguanosine 2'-deoxy-8-hydroxyguanosine 2'-deoxy-8-oxoguanosine NCIT:C219 MIO:01413 A mineralocorticoid hormone produced by aldosterone synthase (CYP11B2) in the zona glomerulosa of the adrenal cortex. Aldosterone binds to mineralocorticoid receptors (MR; NR3C2) and MR-aldosterone complexes regulate the expression of genes involved in the retention of sodium, the secretion of potassium, and water reabsorption, all of which may result increased blood pressure. [url:http://purl.obolibrary.org/obo/NCIT_C219] aldosterone (+)-Aldosterone MIO:01414 alkyl-phosphatidylcholine CHEBI:149669 MIO:01415 A 12 amino acid oligopeptide fragment of apelin-13 lacking the terminal L-phenylalanine residue.[url:http://purl.obolibrary.org/obo/CHEBI_149669] apelin-12 L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-proline MIO:01416 apelin-36 MIO:01417 The ratio between the levels of arachidonic acid and dihomogammalinolenic acid. arachidonic acid/dihomogammalinolenic acid ratio NCIT:C305 MIO:01418 A dark orange, yellow pigment that is the product of the breakdown of iron in the blood; it is conjugated in the liver and excreted in the bile. [url:http://purl.obolibrary.org/obo/NCIT_C305] bilirubin MIO:01419 Cerium is a chemical element with the symbol Ce and atomic number 58. Cerium is a soft, ductile, and silvery-white metal that tarnishes when exposed to air. Cerium is the second element in the lanthanide series, and while it often shows the +3 oxidation state characteristic of the series, it also has a stable +4 state that does not oxidize water. It is also considered one of the rare-earth elements. Cerium has no biological role in humans and is not very toxic.[url:https://en.wikipedia.org/wiki/Cerium] cerium NCIT:C391 MIO:01420 An element with atomic symbol Cu, atomic number 29, and atomic weight 63. [url:http://purl.obolibrary.org/obo/NCIT_C391] copper Cu CHEBI:16814 MIO:01421 A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone. [url:http://purl.obolibrary.org/obo/CHEBI_16814] dehydroepiandrosterone sulfate 17-oxoandrost-5-en-3beta-yl hydrogen sulfate PMID:30406496 MIO:01422 Derivatives of reactive oxygen metabolites (d-ROMs) levels, as a proxy for the reactive oxygen species burden. [PMID:30406496] derivatives of reactive oxygen metabolites d-ROMs MIO:01423 Glutarylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:. acyl-CoA + glycine < -- > CoA + N-acylglycine. Glutarylglycine is involved in lysine metabolism. An elevated level of glutarylglycine occurs in patients with glutaric acidemia type II, which is an autosomal recessive inborn error of metabolism due to a mitochondrial respiratory electron chain transport defect. [url:http://www.pediatricneuro.com/alfonso/pg75.html] glutarylglycine NCIT:C523 MIO:01424 A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes. [url:http://purl.obolibrary.org/obo/NCIT_C523] glutathione -(N-L-gamma-glutamyl-L-cysteinyl)glycine GSH Glutham Reduced Glutathione NCIT:C524 MIO:01425 A non-essential, non-polar, non-optical, glucogenic amino acid. Glycine, an inhibitory neurotransmitter in the CNS, triggers chloride ion influx via ionotropic receptors, thereby creating an inhibitory post-synaptic potential. In contrast, this agent also acts as a co-agonist, along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is an important component and precursor for many macromolecules in the cells. [url:http://purl.obolibrary.org/obo/NCIT_C524] glycine Gly aminoethanoic acid NCIT:C28153 MIO:01426 Linear polysaccharides composed of disaccharide repeating units of glycosamine-glycans, two monosaccharide units (hexosamine and the repeating disaccharide of either hexuronate or galactose) located on the surface of cells or in the extracellular matrix contributing to adhesion, elasticity, and viscosity of extracellular substances. [url:http://purl.obolibrary.org/obo/NCIT_C28153] glycosaminoglycan GAG mucopolysaccharide CHEBI:24996 MIO:01427 A hydroxy monocarboxylic acid anion that is the conjugate base of lactic acid, arising from deprotonation of the carboxy group.[url:http://purl.obolibrary.org/obo/CHEBI_24996] lactate 2-hydroxypropanoate NCIT:C1965 MIO:01428 Lutein (LOO-teen) is a oxygenated carotenoid found in vegetables and fruits. lutein is found in the macula of the eye, where it is believed to act as a yellow filter. Lutein acts as an antioxidant, protecting cells against the damaging effects of free radicals. [url:http://purl.obolibrary.org/obo/NCIT_C1965] lutein (3R,3'R,6'R)-beta,epsilon-Carotene-3,3'-diol 4-[18-(4-hydroxy-2,6,6-trimethyl-1-cyclohex-2-enyl)-3,7,12,16-tetramethyl-octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethyl-cyclohex-3-en-1-ol LUT adaptinol all-trans-lutein leutin xanthophyll xanthophylls NCIT:C2226 MIO:01429 A linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. As a class, carotenoids are pigment compounds found in photosynthetic organisms (plants, algae, and some types of fungus), and are chemically characterized by a large polyene chain containing 35-40 carbon atoms; some carotenoid polyene chains are terminated by two 6-carbon rings. In animals, carotenoids such as lycopene may possess antioxidant properties which may retard aging and many degenerative diseases. As an essential nutrient, lycopene is required in the animal diet. (NCI04) [url:http://purl.obolibrary.org/obo/NCIT_C2226] lycopene 2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene Lyc-O-Mato all-trans-Lycopene psi,psi-Carotene CHEBI:40410 MIO:01430 An N-acylglycine where the acyl group is specified as acetyl.[url:http://purl.obolibrary.org/obo/CHEBI_40410] N-acetylglycine (acetylamino)acetic acid MIO:01431 Nonanoylcarnitine is an acylcarnitine. More specifically, it is an nonanoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago.[url:https://hmdb.ca/metabolites/HMDB0013288] nonanoylcarnitine CHEBI:26020 MIO:01432 Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom. [url:http://purl.obolibrary.org/obo/CHEBI_26020] phosphate phosphates NCIT:C68419 MIO:01433 An ether lipid in which glycerol is covalently bound to a polar phospholipid head group like choline or ethanolamine, a typical ester-linked fatty acid, and an ether-linked fatty acid, which is usually a vinyl alcohol. Plasmalogens occur in nervous tissues, testes and kidneys at significant levels in vertebrates. [url:http://purl.obolibrary.org/obo/NCIT_C68419] plasmalogen NCIT:C825 MIO:01434 A nonmetallic chemical element found in trace amounts in human body. Selenium primarily occurs in vivo as selenocompounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase (enzymes responsible for detoxification). Alone or in combination with Vitamin E, selenocompounds act as antioxidants. These agents scavenge free radicals; prevent blood clots by inhibiting platelet aggregation; strengthen the immune system; and have been shown, in some instances, to inhibit chromosomal damage and mutations. Exhibiting chemopreventive activity, selenocompounds also inhibit the induction of protein kinase C. [url:http://purl.obolibrary.org/obo/NCIT_C825] selenium Se CHEBI:26806 MIO:01435 A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of succinic acid. [url:http://purl.obolibrary.org/obo/CHEBI_26806] succinate MIO:01436 Sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside, is a class of sulfolipids, specifically a class of sulfoglycolipids, which are glycolipids that contain a sulfate group. [url:https://en.wikipedia.org/wiki/Sulfatide] sulfatide 3-O-sulfogalactosylceramide SM4 sulfated galactocerebroside MIO:01437 Thiobarbituric acid reactive substances (TBARS) are formed as a byproduct of lipid peroxidation (i.e. as degradation products of fats) which can be detected by the TBARS assay using thiobarbituric acid as a reagent. TBARS can be upregulated, for example, by heart attack[1] or by certain kinds of stroke. [url:https://en.wikipedia.org/wiki/TBARS] thiobarbituric acid reactive substances TBARS MIO:01438 Threonylglycine is a dipeptide composed of threonine and glycine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. [url:https://hmdb.ca/metabolites/HMDB0029061] threonylglycine NCIT:C107560 MIO:01439 An eicosanoid and biologically inactive metabolite of thromboxane A2. Thromboxane B2 is released during anaphylaxis. As thromboxane A2 has a short half-life, the levels of thromboxane B2 can be used to indirectly measure the production of thromboxane A2 [url:http://purl.obolibrary.org/obo/NCIT_C107560] thromboxane B2 (5Z,13E,15S)-9alpha,11,15-Trihydroxythromboxa-5,13-Dien-1-Oic acid 5-Heptenoic Acid, 7-(Tetrahydro-4,6-Dihydroxy-2-(3-Hydroxy-1-Octenyl)- 2H-Pyran-3-Yl)-, (2R-(2alpha(1E,3S*),3beta(Z),4beta,6alpha))- TXB2 Thromboxa-5,13-Dien-1-Oic Acid, 9,11,15-Trihydroxy-, (5Z,9alpha,13E,15S)- MIO:01440 Trimethylamine N-oxide (TMAO) is an organic compound with the formula (CH3)3NO. It is in the class of amine oxides. Although the anhydrous compound is known, trimethylamine N-oxide is usually encountered as the dihydrate. Both the anhydrous and hydrated materials are white, water-soluble solids. [url:https://en.wikipedia.org/wiki/Trimethylamine_N-oxide] trimethylamine N-oxide TMAO MOD:00083 MIO:01441 A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine. [MOD:00083] trimethyllysine 6-N-L-trimethyl-L-lysine NCIT:C948 MIO:01442 An element with atomic symbol Zn, atomic number 30, and atomic weight 65.39. [url:http://purl.obolibrary.org/obo/NCIT_C948] zinc Zn NCIT:C81627 MIO:01443 The active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. [url:http://purl.obolibrary.org/obo/NCIT_C81627] pyridoxal phosphate PLP active vitamin B6 PR:O00468 MIO:01444 An agrin that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_O00468] agrin AGRIN AGRN hAGRN NCIT:C25293 NCIT:C64433 UMLS:C0201836 UMLS:C0376147 MIO:01445 An enzyme found in the liver and other tissues. A high level of serum glutamate pyruvate transaminase released into the blood may be a sign of liver damage, cancer, or other diseases. [url:http://purl.obolibrary.org/obo/NCIT_C25293] alanine aminotransferase ALT SGPT alanine transaminase NCIT:C214 MIO:01446 A family of globular proteins found in many plant and animal tissues that tend to bind a wide variety of ligands. Albumin is the main protein in blood plasma. Low serum levels occur in conditions associated with malnutrition, inflammation and liver and kidney diseases. [url:http://purl.obolibrary.org/obo/NCIT_C214] albumin ALB NCIT:C107565 MIO:01447 A family of hydrolases that cleaves alpha-linkages in polysaccharides, such as starch and glycogen, and yield glucose and maltose. This family includes the amylase forms that are produced by mammals. In humans, alpha-amylase is produced by salivary glands and the pancreas. [url:http://purl.obolibrary.org/obo/NCIT_C107565] alpha-amylase 1,4-alpha-d-glucan glucanohydrolase 4-alpha-d-glucan glucanohydrolase alpha amylase alpha-amylase ec 3.2.1.1 endoamylase glycogenase EFO:0005200 NCIT:C102258 NCIT:C121327 UMLS:C0201534 MIO:01448 A class of autoantibodies directed against phospholipids or phospholipoproteins. Its presence may indicate an increased risk for hypercoagulability, pregnancy loss or autoimmune disease. [url:http://purl.obolibrary.org/obo/NCIT_C121327] antiphospholipid antibody APLA APLAB anti-phospholipid antibody antiphospholipid antibodies antiphospholipid antibody NCIT:C116419 NCIT:C74733 MIO:01449 Apolipoprotein A-I (267 aa, ~31 kDa) is encoded by the human APOA1 gene. This protein is involved in the transport and metabolism of cholesterol. [url:http://purl.obolibrary.org/obo/NCIT_C116419] apolipoprotein A-I APOA1 Apo-AI ApoA-I apolipoprotein A1 NCIT:C25202 UMLS:C0242192 MIO:01450 An enzyme found in the liver, heart, and other tissues. A high level of serum glutamic-oxaloacetic transaminase released into the blood may be a sign of liver or heart damage, cancer, or other diseases [url:http://purl.obolibrary.org/obo/NCIT_C25202] aspartate aminotransferase AAT ASAT AST AspAT EC 2.6.1.1 SGOT aspartate transaminase glutamic oxaloacetic transaminase NCIT:C111327 PMID:29083808 UMLS:C0523952 MIO:01451 Troponin is the most specific lab test and has two isoforms, I and T. Troponins peak at 12 hours and persist for seven days. [url:https://pubmed.ncbi.nlm.nih.gov/29083808/] cardiac troponin cTn troponin NCIT:C20528 NCIT:C82007 MIO:01452 CD40 ligand (261 aa, ~29 kDa) is encoded by the human CD40LG gene. This protein is involved in both binding to CD40 and the modulation of B-cell function. [url:http://purl.obolibrary.org/obo/NCIT_C20528] CD40 ligand CD-40-ligand CD154 CD154 antigen CD40 antigen ligand CD40-L CD40-ligand CD40L CD40LG HIGM1 IMD3 T cell antigen gp39 T-B cell-activating molecule T-BAM T-cell antigen Gp39 TNF-related activation protein TNFSF5 TRAP gp39 sCD40L tumor necrosis factor ligand superfamily member 5 EFO:0004458 MeSH:D002097 NCIT:C60651 NCIT:C64548 SNOMED:55235003 MIO:01453 An acute phase reactant used in the evaluation of systemic inflammation. [url:http://purl.obolibrary.org/obo/NCIT_C60651] C-reactive protein CRP Pentraxin 1 Pentraxin 1, Short NCIT:C113245 NCIT:C64489 MIO:01454 An enzyme complex that can reversibly convert ATP and creatine to phosphocreatine and ADP. Cytosolic creatine kinases are comprised of homodimers or heterodimers of creatine kinase B-type protein and creatine kinase M-type protein. Mitochondrial creatine kinases are octomers comprised of either four homodimers of creatine kinase U-type, mitochondrial protein or four creatine kinase S-type, mitochondrial protein homodimers. [url:http://purl.obolibrary.org/obo/NCIT_C113245] creatine kinase ATP:Creatine N-Phosphotransferase Adenosine Triphosphate-Creatine Transphosphorylase CK CPK Creatine Phosphokinase Creatine Phosphotransferase Phosphocreatine Kinase NCIT:C1285 MIO:01455 Endothelin-1 is proteolytically processed to form big endothelin-1 (38 amino acids) or a 21 amino acid peptide also called endothelin-1. The active forms inhibits active Na-K transport by inhibiting Na(+)-K(+)-ATPase in intact renaltubular epithelial cells. [url:http://purl.obolibrary.org/obo/NCIT_C1285] endothelin-1 ENDOTH1 ET-1 PPET1 endothelin 1 preproendothelin 1 preproendothelin-1 NCIT:C25736 NCIT:C64606 PMID:33620437 UMLS:C0016006 UMLS:C0337428 MIO:01456 A fibrillar protein present in blood plasma; it converts to fibrin during the process of blood clot formation. [url:http://purl.obolibrary.org/obo/NCIT_C25736] fibrinogen FIBRINO fibrinogen antigen NCIT:C37959 OMIT:0006923 SNOMED:60153001 TXPO:0000858 MIO:01457 GGT participates in the transfer of amino acids across the cellular membrane and in glutathione metabolism. High concentrations are found in the liver, bile ducts, and the kidney. A test that measures the amount of GGT in the blood is used to detect diseases of the liver, bile ducts, and kidney; and to differentiate liver or bile duct (hepatobiliary) disorders from bone disease. [url:http://purl.obolibrary.org/obo/NCIT_C37959] gamma-glutamyltransferase EC 2.3.2.2 EC 3.4.19.13 GGT gamma gTP gamma glutamyl transferase gamma-GGT gamma-GT gamma-glutamyl endopeptidase gamma-glutamyl transferase gamma-glutamyl transpeptidase gamma-glutamyltransferase glutamyl transpeptidase γ-GGT γ-glutamyl endopeptidase CHEBI:17089 EFO:0004555 NCIT:C16642 MIO:01458 A compound in which a carbohydrate component is covalently bound to a protein component. [url:http://purl.obolibrary.org/obo/CHEBI_17089] glycoprotein NCIT:C565 MIO:01459 IgA is the immunoglobulin subclass that is associated with antibody-mediated mucosal immunity. It is secreted as dimers into the mucosa and is the most effective isotype at fixing complement by the alternative pathway, even though it lacks the ability to fix complement by the classical pathway. There are two subtypes in the human - IgA1 and IgA2. [url:http://purl.obolibrary.org/obo/NCIT_C565] IgA immunoglobulin A NCIT:C567 MIO:01460 An immunoglobulin isotype (subclass). This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast cells and basophils and induce degranulation and cytokine production by these cells when they are crosslinked by antigen. In addition to a central role in atopy and allergic responses, it has been speculated that IgE-mediated mast cell degranulation, by its release of mediators that increase vascular permeability, has an important role in the initiation of immune response in general. [url:http://purl.obolibrary.org/obo/NCIT_C567] IgE immunoglobulin E NCIT:C568 MIO:01461 An immunoglobulin isotype (subclass) that characterizes secondary immune responses. This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli. [url:http://purl.obolibrary.org/obo/NCIT_C568] IgG immunoglobulin G NCIT:C20497 MIO:01462 Interleukin is the generic name for a group of well-characterized cytokines that are produced by leukocytes and other cell types. They have a broad spectrum of functional activities that regulate the activities and capabilities of a wide variety of cell types. They are particularly important as members of the cytokine networks that regulate inflammatory and immune responses. [url:http://purl.obolibrary.org/obo/NCIT_C20497] interleukin IL interleukins NCIT:C25184 NCIT:C64855 PMID:29083808 UMLS:C0202113 MIO:01463 LDH peaks over 72 hours and normalizes over ten to 14 hours. In clinical practice, LDH is not used to diagnose acute MI.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] One of a group of enzymes found in the blood and other body tissues and involved in energy production in cells. An increased amount of lactate dehydrogenase in the blood may be a sign of tissue damage and some types of cancer or other diseases. [url:http://purl.obolibrary.org/obo/NCIT_C25184] lactate dehydrogenase EC 1.1.1.27 L-(+)-Lactate Dehydrogenase L-Lactic Acid Dehydrogenase LDH Lactic Acid Dehydrogenase NAD-Lactate Dehydrogenase NCIT:C25187 MIO:01464 A lipoprotein that carries cholesterol around the body, for use by various cells. LDL transports cholesterol to the arteries and increased levels are associated with atherosclerosis, and thus myocardial infarctions and strokes. This is why cholesterol inside LDL lipoproteins is called bad cholesterol. [url:http://purl.obolibrary.org/obo/NCIT_C25187] low-density lipoprotein LDL NCIT:C18164 MIO:01465 Matrix metalloproteinases are Zn(2+)-binding endopeptidases that degrade components of the extracellular matrix. These enzymes are implicated in tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. Matrix metalloproteinases have been associated with the development of advanced-stage cancer via their role in tumor progression, invasion, and metastasis. [url:http://purl.obolibrary.org/obo/NCIT_C18164] matrix metalloproteinase MMP matrix metalloproteas matrix metalloproteinases NCIT:C79436 PR:000010213 UMLS:C0373680 MIO:01466 Myoglobin (symbol Mb or MB) is an iron- and oxygen-binding protein found in the cardiac and skeletal muscle tissue of vertebrates in general and in almost all mammals. Myoglobin is distantly related to hemoglobin. Compared to hemoglobin, myoglobin has a higher affinity for oxygen and does not have cooperative-binding with oxygen like hemoglobin does. In humans, myoglobin is only found in the bloodstream after muscle injury. [url:https://en.wikipedia.org/wiki/Myoglobin] myoglobin MB MGB PR:000030444 MIO:01467 Osteocalcin (100 aa, ~11 kDa) is encoded by the human BGLAP gene. This protein is involved in bone development. [url:http://purl.obolibrary.org/obo/NCIT_C104592] osteocalcin BGLAP BGP bone Gla protein bone gamma-carboxyglutamic acid-containing protein gamma-carboxyglutamic acid-containing protein PR:P35318 MIO:01468 ADM (185 aa, ~20 kDa) is encoded by the human ADM gene. This protein plays a role in both signal transduction and vasodilation. ADM protein is cleaved into 2 chains adrenomedullin and proadrenomedullin N-20 terminal peptide (PAMP or ProAM-N20). [url:http://purl.obolibrary.org/obo/NCIT_C113266] pro-adrenomedullin ADM ADM precursor PAMP PreproAM ProAM adrenomedullin preproadrenomedullin NCIT:C82854 MIO:01469 Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen. [url:http://purl.obolibrary.org/obo/NCIT_C82854] prothrombin coagulation factor ii ec 3.4.21.5 f2 factor ii prothrombin NCIT:C28774 MIO:01470 Stromal cell-derived factor 1 (93 aa, ~11 kDa) is encoded by the human CXCL12 gene. This protein is involved in signal transduction and chemotaxis of T-lymphocytes, and monocytes. [url:http://purl.obolibrary.org/obo/NCIT_C28774] stromal cell-derived factor 1 C-X-C motif chemokine 12 CXCL12 IRH PBSF SDF-1 SDF-1-Beta(1-72) SDF1 chemokine (C-X-C Motif) ligand 12 hIRH hSDF-1 hSDF-1beta intercrine reduced in hepatomas pre-B cell growth stimulating factor pre-B cell growth-stimulating factor stromal cell-derived factor 1 NCIT:C17172 MIO:01471 Proteins that protect cells against elevated levels of superoxide a reactive oxygen species. These antioxidant enzymes catalyze the formation of molecular oxygen and hydrogen peroxide from the superoxide anion. They are also potential therapeutic agents in diseases related to oxidative stress and in the regulation of the aging process. [url:http://purl.obolibrary.org/obo/NCIT_C17172] superoxide dismutase e.c. 1.15.1.1 superoxide dismutase EFO:0005416 MIO:01472 A soluble ST2 measurement is the quantification of the ST2 protein, also known as Interleukin-1 receptor-like 1 or IL1RL1. The protein ST2 levels are associated with adverse cardiovascular events. [url:http://www.ebi.ac.uk/efo/EFO_0005416] suppression of tumorigenicity 2 ST2 sST2 soluble ST2 soluble suppression of tumorigenicity 2 NCIT:C20535 MIO:01473 Tumor necrosis factor (233 aa, ~26 kDa) is encoded by the human TNF gene. This protein is involved in the induction of cytokine expression, the stimulation of cell proliferation and the positive regulation of cell differentiation. Tumor necrosis factor (TNF) is a serum glycoprotein produced by activated macrophages and other mammalian mononuclear leukocytes which has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. [url:http://purl.obolibrary.org/obo/NCIT_C20535] tumor necrosis factor TNF TNF alpha TNF-A TNF-alpha TNFA tumor necrosis factor alpha tumor necrosis factor ligand superfamily member 2 tumor necrosis factor-alpha NCIT:C124129 MIO:01474 A heterotrimeric fibrillar protein complex comprised of two collagen alpha-1(I) chains and one collagen alpha-2(I) chains. Type I collagen is the most abundant fibrillar collagen in humans and is present in scar tissue, tendons, ligaments, bone, dermis, dentin, and organ capsules. [url:http://purl.obolibrary.org/obo/NCIT_C124129] type I collagen collagen 1 collagen i collagen type 1 collagen type i type 1 collagen type i collagen NCIT:C104200 MIO:01475 Type III procollagen N-terminal peptide (130 aa, ~13 kDa) is encoded by the human COL3A1 gene. This protein is produced by the cleavage of procollagen chains. Once the N-terminal peptides are removed, triple helical collagen fibrils can form. Increased serum levels of this peptide are associated with liver diseases. [url:http://purl.obolibrary.org/obo/NCIT_C104200] type III procollagen N-terminal peptide p3np pro-c3 pro-peptide of type lll collagen procollagen-3 n-terminal peptide procollagen-iii n-terminal peptide type iii procollagen n-terminal peptide NCIT:C20450 MIO:01476 Vascular endothelial growth factor A (232 aa, ~27 kDa) is encoded by the human VEGFA gene. This protein plays a role in both cell proliferation and angiogenesis. [url:http://purl.obolibrary.org/obo/NCIT_C20450] vascular endothelial growth factor A VEGF VEGF121 VEGF145 VEGF148 VEGF165 VEGF183 VEGF189 VEGF206 VPF vascular endothelial growth factor vascular permeability factor NCIT:C127612 MIO:01477 Copeptin (also known as CT-proAVP) is a 39-amino acid-long peptide derived from the C-terminus of pre-pro-hormone of arginine vasopressin, neurophysin II and copeptin. Arginine vasopressin (AVP), also known as the antidiuretic hormone (ADH), is encoded by the AVP gene and is involved in multiple cardiovascular and renal pathways and abnormal level of AVP are associated with various diseases. Hence measurement of AVP would be useful, but is not commonly carried out in clinical practice because of its very short half-life making it difficult to quantify. In contrast, copeptin can be immunologically tested with ease and therefore can be used as a vasopressin surrogate marker. [url:https://en.wikipedia.org/wiki/CopeptinAcute_myocardial_infarction] vasopressin-neurophysin 2-copeptin C-terminal provasopressin COPEP CT-pro AVP CT-proAVP copeptin NCIT:C104340 MIO:01478 60 kDa heat shock protein, mitochondrial (573 aa, ~61 kDa) is encoded by the human HSPD1 gene. This protein plays a role in mitochondrial protein folding. [url:http://purl.obolibrary.org/obo/NCIT_C104340] 60 kDa heat shock protein, mitochondrial 60 kda chaperonin 60 kda heat shock protein, mitochondrial chaperonin 60 cpn60 heat shock protein 60 heat shock protein 65 hsp-60 hsp60 hspd1 hucha60 mitochondrial matrix protein p1 p60 lymphocyte protein short heat shock protein 60 hsp60s1 EFO:0009269 NCIT:C118327 PMID:33620437 MIO:01479 A disintegrin and metalloproteinase with thrombospondin motifs 13 (1427 aa, ~154 kDa) is encoded by the human ADAMTS13 gene. This protein plays a role in the proteolysis of von Willebrand factor multimers. [url:http://purl.obolibrary.org/obo/NCIT_C118327] a disintegrin and metalloproteinase with thrombospondin motifs 13 ADAM-TS 13 ADAM-TS13 ADAMTS-13 ADAMTS13 EC 3.4.24.87 a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 a disintegrin and metalloproteinase with thrombospondin motifs-13 vWF-CP vWF-Cleaving Protease PR:P22303 MIO:01480 An acetylcholinesterase that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P22303] acetylcholinesterase ACHE hACHE NCIT:C120022 NCIT:C80163 UMLS:C0001109 MIO:01481 A family of phosphatases that add monophosphates to substrates. The optimal pH for activity of these enzymes is below 7. [url:http://purl.obolibrary.org/obo/NCIT_C120022] acid phosphatase ACPHOS EC 3.1.3.2 acid monophosphatase acid nucleoside diphosphate phosphatase acid phosphomonoester hydrolase acid phosphomonoesterase alycerophosphatase orthophosphoric-monoester phosphohydrolase phosphate-monoester phosphohydrolase phosphomonoesteras PR:P68133 MIO:01482 An actin, alpha skeletal muscle that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P68133] actin, alpha skeletal muscle ACTA ACTA1 alpha-actin-1 hACTA1 NCIT:C103972 MIO:01483 Actin, aortic smooth muscle (377 aa, ~42 kDa) is encoded by the human ACTA2 gene. This protein plays a role in the contraction of smooth muscle. [url:http://purl.obolibrary.org/obo/NCIT_C103972] actin, aortic smooth muscle acta2 actin, aortic smooth muscle alpha-actin-2 alpha-cardiac actin alpha-sma cell growth-inhibiting gene 46 protein NCIT:C30011 MIO:01484 Actin, gamma-enteric smooth muscle (376 aa, ~42 kDa) is encoded by the human ACTG2 gene. This protein plays a role in the cytoskelton and cell motility. [url:http://purl.obolibrary.org/obo/NCIT_C30011] actin, gamma-enteric smooth muscle actg2 actin, alpha-3 actin, gamma 2 actin, gamma 2, smooth muscle, enteric actin, gamma-enteric smooth muscle actin-like protein 3 alpha-actin 3 alpha-actin-3 gamma-2-actin smooth muscle gamma-actin NCIT:C26612 MIO:01485 Activin receptor type-1 (509 aa, ~57 kDa) is encoded by the human ACVR1 gene. This protein is involved in embryonic development, protein phosphorylation, and signal transduction. [url:http://purl.obolibrary.org/obo/NCIT_C26612] activin receptor type-1 activin a receptor, type i activin a receptor, type ii-like kinase 2 activin receptor type i activin receptor type-1 activin receptor-like kinase 2 actr-i acvr1 alk-2 serine/threonine-protein kinase receptor r1 skr1 tgf-b superfamily receptor type i tsr-i NCIT:C16261 MIO:01486 Adenosine deaminase (363 aa, ~41 kDa) is encoded by the human ADA gene. This protein plays a role in purine metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C16261] adenosine deaminase ada adenine deaminase adenosine aminohydrolase adenosine deaminase ec 3.5.4.4 PR:Q5T7M4 MIO:01487 An adipolin that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q5T7M4] adipolin C1QDC2 C1QTNF12 C1q and TNF related protein 12 CTRP12 FAM132A adipose-derived insulin-sensitizing factor complement C1q tumor necrosis factor-related protein 12 hC1QTNF12 NCIT:C74839 MIO:01488 Adiponectin (244 aa, ~26 kDa) is encoded by the human ADIPOQ gene. This protein is involved in the modulation of both glucose metabolism and lipid homeostasis. [url:http://purl.obolibrary.org/obo/NCIT_C94786] adiponectin 30 kDa adipocyte complement-related protein ACRP30 ADPNCTN APN AdipoQ GBP-28 adipocyte complement-related 30 kDa protein adipocyte, C1q and collagen domain-containing protein adipocyte-specific secretory protein adipose most abundant gene transcript 1 protein apM-1 gelatin-binding protein gelatin-binding protein, 28-kD PR:O95450 MIO:01489 An a disintegrin and metalloproteinase with thrombospondin motifs 2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_O95450] a disintegrin and metalloproteinase with thrombospondin motifs 2 ADAM-TS 2 ADAM-TS2 ADAMTS-2 ADAMTS2 PC I-NP PCINP PCPNI hADAMTS2 pNPI procollagen I N-proteinase procollagen I/II amino propeptide-processing enzyme procollagen N-endopeptidase PR:O15072 MIO:01490 An a disintegrin and metalloproteinase with thrombospondin motifs 3 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_O15072] a disintegrin and metalloproteinase with thrombospondin motifs 3 ADAM-TS 3 ADAM-TS3 ADAMTS-3 ADAMTS3 KIAA0366 PC II-NP hADAMTS3 procollagen II N-proteinase procollagen II amino propeptide-processing enzyme PR:Q9UKP4 MIO:01491 An a disintegrin and metalloproteinase with thrombospondin motifs 7 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9UKP4] a disintegrin and metalloproteinase with thrombospondin motifs 7 ADAM-TS 7 ADAM-TS7 ADAMTS-7 ADAMTS7 COMPase hADAMTS7 PR:Q9P2N4 MIO:01492 An a disintegrin and metalloproteinase with thrombospondin motifs 9 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9P2N4] a disintegrin and metalloproteinase with thrombospondin motifs 9 ADAM-TS 9 ADAM-TS9 ADAMTS-9 ADAMTS9 KIAA1312 hADAMTS9 PR:Q6UWT2 MIO:01493 An adropin that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q6UWT2] adropin C9orf165 ENHO UNQ470/PRO830 energy homeostasis-associated protein hENHO NCIT:C106214 MIO:01494 Advanced glycosylation end product-specific receptor (404 aa, ~43 kDa) is encoded by the human AGER gene. This protein is involved in advanced glycation end product binding, inflammatory responses and receptor-mediated signaling. [url:http://purl.obolibrary.org/obo/NCIT_C106214] advanced glycosylation end product-specific receptor advanced glycosylation end product-specific receptor ager rage receptor for advanced glycosylation end products NCIT:C129393 UMLS:C0001990 MIO:01495 A family of enzymes that either create or cleave aldols (aldehyde alcohols). [url:http://purl.obolibrary.org/obo/NCIT_C129393] aldolase Aldehyde-Lyase EC 4.1.2 NCIT:C16276 MIO:01496 An enzyme that catalyses the cleavage of inorganic phosphate non-specifically from a wide variety of phosphate esters and having a high (greater than 8) pH optimum. [url:http://purl.obolibrary.org/obo/NCIT_C16276] alkaline phosphatase alk phos alkaline phosphatase alkp alkphos alp ap phosphatase, alkaline NCIT:C111126 UMLS:C0919751 MIO:01497 The determination of the amount of alpha-hydroxybutyrate dehydrogenase present in a sample. [url:http://purl.obolibrary.org/obo/NCIT_C111126] alpha hydroxybutyrate dehydrogenase AHBDH alpha-hydroxybutyrate dehydrogenase NCIT:C126967 MIO:01498 Alpha-1-acid glycoprotein 1 (201 aa, ~24 kDa) is encoded by the human ORM1 gene. This protein may play a role in immunosuppression and small molecule transport. [url:http://purl.obolibrary.org/obo/NCIT_C126967] alpha-1-acid glycoprotein 1 agp 1 alpha-1-acid glycoprotein alpha-1-acid glycoprotein 1 epididymis secretory sperm binding protein li 153w omd 1 orm1 orosomucoid 1 orosomucoid-1 NCIT:C116579 MIO:01499 Alpha-1-antichymotrypsin (423 aa, ~48 kDa) is encoded by the human SERPINA3 gene. This protein is involved in the inhibition of neutrophil cathepsin G and mast cell chymase proteolytic activity. [url:http://purl.obolibrary.org/obo/NCIT_C116579] alpha-1-antichymotrypsin act alpha-1-antichymotrypsin cell growth-inhibiting gene 24/25 protein growth-inhibiting protein 24 growth-inhibiting protein 25 serpin a3 NCIT:C105012 MIO:01500 Alpha-1-antitrypsin (418 aa, ~47 kDa) is encoded by the human SERPINA1 gene. This protein plays a role in regulation of proteolysis. [url:http://purl.obolibrary.org/obo/NCIT_C105012] alpha-1-antitrypsin alpha-1 antitrypsin alpha-1 protease inhibitor alpha-1-antiproteinase alpha-1-antitrypsin alpha1at anti-elastase protease inhibitor 1 serine (or cysteine) proteinase inhibitor, clade a, member 1 serpin a1 serpin family a member 1 serpin peptidase inhibitor clade a member 1 serpina1 NCIT:C105924 PMID:33620437 MIO:01501 Alpha-2-macroglobulin (1474 aa, ~163 kDa) is encoded by the human A2M gene. This protein has activity as a protease inhibitor. [url:http://purl.obolibrary.org/obo/NCIT_C105924] alpha-2 macroglobulin A2MACG Alpha-2-M C3 and PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 alpha-2-macroglobulin α2-macroglobulin α2M NCIT:C129263 MIO:01502 Alpha-2-antiplasmin (491 aa, ~55 kDa) is encoded by the human SERPINF2 gene. This protein plays a role in the regulation of plasmin-mediated processes during blood coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C129263] alpha-2-antiplasmin alpha-2-antiplasmin alpha-2-ap alpha-2-pi alpha-2-plasmin inhibitor serpin f2 NCIT:C113823 MIO:01503 Alpha-2-HS-glycoprotein (367 aa, ~39 kDa) is encoded by the human AHSG gene. This protein is involved in the regulation of bone mineralization. [url:http://purl.obolibrary.org/obo/NCIT_C113823] alpha-2-HS-glycoprotein alpha-2-hs-glycoprotein alpha-2-z-globulin ba-alpha-2-glycoprotein fetuin a fetuin-a NCIT:C18042 MIO:01504 Angiopoietin-1 (498 aa, ~58 kDa) is encoded by the human ANGPT1 gene. This protein is involved in both signal transduction and angiogenesis. [url:http://purl.obolibrary.org/obo/NCIT_C18042] angiopoietin-1 ang-1 ang1 angiopoietin 1 angiopoietin-1 angpt1 NCIT:C18056 MIO:01505 Angiopoietin-2 (496 aa, ~57 kDa) is encoded by the human ANGPT2 gene. This protein plays a role in the regulation of endothelial cell apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C18056] angiopoietin-2 ang-2 ang2 angiopoietin 2 angiopoietin-2 angpt2 tie2-ligand PR:Q9UKU9 MIO:01506 An angiopoietin-related protein 2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9UKU9] angiopoietin-related protein 2 ANGPTL2 ARP2 UNQ170/PRO196 angiopoietin-like protein 2 hANGPTL2 NCIT:C96325 MIO:01507 Angiopoietin-related protein 4 (406 aa, ~45 kDa) is encoded by the human ANGPTL4 gene. This protein plays a role in the modulation of signaling during hypoxic stress and angiogenesis. [url:http://purl.obolibrary.org/obo/NCIT_C96325] angiopoietin-related protein 4 angiopoietin-like protein 4 angiopoietin-related protein 4 hepatic fibrinogen/angiopoietin-related protein hfarp PR:P12821 MIO:01508 Angiotensin-converting enzyme (1306 aa, ~150 kDa) is encoded by the human ACE gene. This protein plays a role in the hydrolysis of angiotensin I to form angiotensin II and the solubilization of glycophophoinositol-anchored proteins from the plasma membrane. [url:http://purl.obolibrary.org/obo/NCIT_C91297] angiotensin-converting enzyme ACE CD143 CD143 antigen EC 3.2.1.- EC 3.4.15.1 angiotensin converting enzyme, somatic isoform angiotensin-converting enzyme carboxycathepsin dipeptidyl carboxypeptidase 1 dipeptidyl carboxypeptidase I kininase II peptidase P peptidyl-dipeptidase A testicular ECA NCIT:C102530 MIO:01509 Angiotensin-converting enzyme 2 (805 aa, ~92 kDa) is encoded by the human ACE2 gene. This protein plays a role in both vasodilation and protein cleavage. [url:http://purl.obolibrary.org/obo/NCIT_C102530] angiotensin-converting enzyme 2 ace-related carboxypeptidase ace2 aceh angiotensin i converting enzyme 2 angiotensin i-converting enzyme 2 angiotensin-converting enzyme 2 angiotensin-converting enzyme homolog ec 3.4.17.23 metalloprotease mprot15 NCIT:C21333 MIO:01510 Annexin A5 (320 aa, ~36 kDa) is encoded by the human ANXA5 gene. This protein plays a role in the inhibition of blood coagulation and the transmembrane transport of calcium. [url:http://purl.obolibrary.org/obo/NCIT_C21333] annexin A5 anchorin cii annexin a5 annexin v annexin-5 anxa5 calphobindin i cbp-i endonexin ii lipocortin v pap-i placental anticoagulant protein 4 placental anticoagulant protein i placental protein 4 pp4 thromboplastin inhibitor vac-alpha vascular anticoagulant-alpha SNOMED:726769004 MIO:01511 antibody to platelet factor 4-heparin complex HIT (Heparin induced thrombocytopenia) antibody anti-platelet factor 4-heparin complex antibody antibodies to the platelet factor 4/heparin complex platelet factor 4-heparin complex antibody PMID:19369878 MIO:01512 anti-phosphorylcholine IgM IgM anti-phosphorylcholine antibody IgM antibodies against phosphorylcholine NCIT:C104098 PR:000004135 MIO:01513 Apelin (77 aa, ~9 kDa) is encoded by the human APLN gene. This protein is involved in both the inhibition of HIV-1 entry into cells and in immune responses. Apelin is a precursor to at least four active peptides that are produced by proteolytic processing of the full length gene product. These active peptides include Apelin-36, Apelin-31, Apelin-28 and Apelin-13. [url:http://purl.obolibrary.org/obo/NCIT_C104098] apelin AGTRL1 ligand APJ endogenous ligand APLN NCIT:C138159 MIO:01514 Apelin receptor (380 aa, ~43 kDa) is encoded by the human APLNR gene. This protein plays a role in G protein-coupled receptor signaling. [url:http://purl.obolibrary.org/obo/NCIT_C138159] apelin receptor angiotensin ii receptor-like 1 angiotensin receptor-like 1 apelin receptor apj receptor aplnr g protein-coupled receptor apj g-protein coupled receptor apj g-protein coupled receptor hg11 hg11 orphan receptor NCIT:C140118 MIO:01515 Apolipoprotein(a) (4548 aa, ~501 kDa) is encoded by the human LPA gene. This protein is involved in the regulation of thrombosis and lipid metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C140118] apolipoprotein(a) antiangiogenic ak38 protein apo(a) apolipoprotein(a) ec 3.4.21.- lpa NCIT:C74734 MIO:01516 Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. Apolipoprotein B is the primary apolipoprotein of chylomicrons, VLDL, Lp(a), IDL, and LDL particles (LDL - known commonly as "bad cholesterol" when in reference to both heart disease and vascular disease in general), which is responsible for carrying fat molecules (lipids), including cholesterol, around the body to all cells within all tissues. While all the functional roles of ApoB within the LDL (and all larger) particles remain somewhat unclear, it is the primary organizing protein (of the entire complex shell enclosing/carrying fat molecules within) component of the particles and is absolutely required for the formation of these particles. What is also clear is that the ApoB on the LDL particle acts as a ligand for LDL receptors in various cells throughout the body (i.e., less formally, ApoB indicates fat carrying particles are ready to enter any cells with ApoB receptors and deliver fats carried within into the cells). [url:https://en.wikipedia.org/wiki/Apolipoprotein_B] apolipoprotein B-100 APOB apolipoprotein B PR:P02652 MIO:01517 An apolipoprotein A-II that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P02652] apolipoprotein A-II APOA2 ApoA-II apo-AII apolipoprotein A2 hAPOA2 NCIT:C117099 MIO:01518 Apolipoprotein C-III (99 aa, ~11 kDa) is encoded by the human APOC3 gene. This protein is involved in the modulation of cellular uptake and metabolism of very low density lipoproteins and chylomicrons. [url:http://purl.obolibrary.org/obo/NCIT_C117099] apolipoprotein C-III apo-cii apoc-iii apoc3 apolipoprotein c-iii apolipoprotein c3 NCIT:C84470 MIO:01519 Apolipoprotein E (317 aa, ~36 kDa) is encoded by the human APOE gene. This protein is involved in lipid metabolism and transport. [url:http://purl.obolibrary.org/obo/NCIT_C84470] apolipoprotein E apo-e apoe apolipoprotein e PR:Q13790 MIO:01520 An apolipoprotein F that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q13790] apolipoprotein F APOF LTIP apo-F hAPOF lipid transfer inhibitor protein NCIT:C104429 MIO:01521 Appetite-regulating hormone (117 aa, ~13 kDa) is encoded by the human GHRL gene. This protein is involved in satiety, thirst and anxiety and regulating growth hormone release. [url:http://purl.obolibrary.org/obo/NCIT_C104429] appetite-regulating hormone appetite-regulating hormone ghrelin ghrelin, growth hormone secretagogue receptor ligand growth hormone secretagogue growth hormone-releasing peptide motilin-related peptide obestatin protein m46 PR:P18859 MIO:01522 An ATP synthase-coupling factor 6, mitochondrial that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P18859] ATP synthase-coupling factor 6, mitochondrial ATP synthase peripheral stalk subunit F6 ATP5A ATP5J ATP5PF ATPM ATPase subunit F6 hATP5PF PR:Q9Y5Q5 MIO:01523 An atrial natriuretic peptide-converting enzyme that is encoded in the genome of human. [url:http://purl.obolibrary.org/obo/PR_Q9Y5Q5] atrial natriuretic peptide-converting enzyme corin hCORIN heart-specific serine proteinase ATC2 pro-ANP-converting enzyme transmembrane protease serine 10 NCIT:C91371 MIO:01524 Atypical chemokine receptor 3 (362 aa, ~41 kDa) is encoded by the human ACKR3 gene. This protein is involved in the negative regulation of chemokine signaling. [url:http://purl.obolibrary.org/obo/NCIT_C91371] atypical chemokine receptor 3 ackr3 atypical chemokine receptor 3 c-x-c chemokine receptor type 7 chemokine orphan receptor 1 cmkor1 cxc-r7 cxcr-7 cxcr7 g protein-coupled receptor 159 g-protein coupled receptor 159 g-protein coupled receptor rdc1 homolog rdc-1 NCIT:C17278 MIO:01525 Azurocidin (251 aa, ~27 kDa) is encoded by the human AZU1 gene. This protein plays a role in chemotaxis and receptor activation. [url:http://purl.obolibrary.org/obo/NCIT_C17278] azurocidin azamp azu azu1 azu1 protein azurocidin azurocidin 1 azurocidin 1 (cationic antimicrobial protein 37) cap37 cationic antimicrobial protein 37 cationic antimicrobial protein, 37kd cationic antimicrobial protein-37 hbp heparin binding protein heparin-binding protein humazur nazc neutrophil azurocidin NCIT:C26101 MIO:01526 B2 bradykinin receptor (391 aa, ~44 kDa) is encoded by the human BDKRB2 gene. This protein plays a role in bradykinin binding and receptor signaling. [url:http://purl.obolibrary.org/obo/NCIT_C26101] B2 bradykinin receptor b2 bradykinin receptor b2r bdkrb2 bk-2 bk-2 receptor bk2 bkr2 bradykinin receptor 2 bradykinin receptor b2 brb2 NCIT:C95070 MIO:01527 Basigin (385 aa, ~42 kDa) is encoded by the human BSG gene. This protein is involved in signal transduction that mediates protease gene expression, implantation, sperm formation and neural development. [url:http://purl.obolibrary.org/obo/NCIT_C95070] basigin 5f7 antigen cd147 basigin cd147 cd147 antigen collagenase stimulatory factor emmprin extracellular matrix metalloproteinase inducer leukocyte activation antigen m6 ok blood group antigen tcsf tumor cell-derived collagenase stimulatory factor NCIT:C103359 MIO:01528 beta-2 glycoprotein 1 IgM antibody APOH IgM antibody B2G1GMAB anti-beta2GPI IgM antibodies apolipoprotein H IgM antibody NCIT:C21292 MIO:01529 Expressed in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Beta Adrenergic Receptor Genes encode Beta Adrenergic Receptors, one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac rate and force of contraction; beta-2 type receptor activation promotes bronchial and vascular smooth muscle relaxation. When coupled to adenylate cyclase through Gs protein, Beta Adrenergic Receptor stimulation results in increased intracellular cyclic AMP. (NCI) [http://purl.obolibrary.org/obo/NCIT_C21292] beta-adrenergic receptor beta adrenergic receptor NCIT:C21382 MIO:01530 Beta-adrenergic receptor kinase 1 (689 aa, ~80 kDa) is encoded by the human GRK2 gene. This protein is involved in both G protein-coupled receptor signaling and muscle contraction. [url:http://purl.obolibrary.org/obo/NCIT_C21382] beta-adrenergic receptor kinase 1 adrbk1 adrenergic beta receptor kinase 1 bark1 beta-adrenergic receptor kinase 1 beta-ark-1 beta-ark1 ec 2.7.1.126 ec 2.7.11.15 g protein-dependent receptor kinase 2 g-protein coupled receptor kinase 2 grk2 PR:P13929 MIO:01531 A beta-enolase that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P13929] beta-enolase 2-phospho-D-glycerate hydro-lyase ENO3 MSE enolase 3 hENO3 muscle-specific enolase skeletal muscle enolase NCIT:C20468 MIO:01532 Beta-thromboglobulin (81 aa, ~9 kDa) is encoded by the human PPBP gene. This protein plays a role in chemotaxis. [url:http://purl.obolibrary.org/obo/NCIT_C20468] beta-thromboglobulin b-tg1 beta tg beta thromboglobulin beta-tg beta-thromboglobulin btg ppbp tgb thromboglobulin, beta-1 NCIT:C21350 MIO:01533 Bone morphogenetic protein 2 (396 aa, ~45 kDa) is encoded by the human BMP2 gene. This protein plays a role in cartilage and bone formation. [url:http://purl.obolibrary.org/obo/NCIT_C21350] bone morphogenetic protein 2 bmp-2 bmp-2a bmp2 bone morphogenetic protein 2 bone morphogenetic protein 2a NCIT:C95043 MIO:01534 Bone morphogenetic protein 4 (408 aa, ~47 kDa) is encoded by the human BMP4 gene. This protein is involved in the mediation of bone, cartilage, tooth and limb development. [url:http://purl.obolibrary.org/obo/NCIT_C95043] bone morphogenetic protein 4 bmp-2b bmp-4 bmp4 bone morphogenetic protein 2b bone morphogenetic protein 4 NCIT:C20445 MIO:01535 Brain-derived neurotrophic factor (247 aa, ~28 kDa) is encoded by the human BDNF gene. This protein plays a role in both the development of the nervous system and neuronal survival. [url:http://purl.obolibrary.org/obo/NCIT_C20445] brain-derived neurotrophic factor abrineurin bdnf brain derived neurotrophic factor brain-derived neurotrophic factor NCIT:C105971 MIO:01536 A heterodimeric or heterotetrameric protein complex comprised of protein S100A8 and protein S100A9. This complex is expressed in the cytosol of neutrophils and macrophages and plays a role in multiple host defense related processes including immunomodulation, neutrophil chemotaxis and both antibacterial and antifungal responses. [url:http://purl.obolibrary.org/obo/NCIT_C105971] calprotectin calprotectin leukocyte l1 complex mrp-8/mrp-14 complex s100a8/a9 complex s100a8/s100a9 complex NCIT:C165953 NCIT:C178158 PMID:33620437 MIO:01537 The carboxypeptidase B2 zymogen is stabilized by interactions with the activation peptide. Thrombin mediates the release of the activation peptide and results in increased mobility of a dynamic flap in the protein structure. This leads to conformational changes that expose a cryptic thrombin-cleavage site present at Arg-324 and contributes to the short half-life of active carboxypeptidase B2. [url:http://purl.obolibrary.org/obo/NCIT_C178158] carboxypeptidase B2 CPB2 CPU Carboxypeptidase B2 Carboxypeptidase U EC 3.4.17.20 PCPB TAFI Thrombin-Activable Fibrinolysis Inhibitor Thrombin-Activatable Fibrinolysis Inhibitor NCIT:C26086 MIO:01538 Cardiotrophin-1 (201 aa, ~21 kDa) is encoded by the human CTF1 gene. This protein plays a role in the neuromuscular development. [url:http://purl.obolibrary.org/obo/NCIT_C26086] cardiotrophin-1 cardiophin 1 cardiotrophin 1 cardiotrophin-1 ctf1 NCIT:C131264 MIO:01539 Cartilage oligomeric matrix protein (757 aa, ~83 kDa) is encoded by the human COMP gene. This protein plays a role in the formation and maintenance of cartilage. [url:http://purl.obolibrary.org/obo/NCIT_C131264] cartilage oligomeric matrix protein cartilage oligomeric matrix protein comp thrombospondin 5 thrombospondin v thrombospondin-5 thrombospondin-v tsp5 NCIT:C61062 MIO:01540 Catalase (527 aa, ~60 kDa) is encoded by the human CAT gene. This protein plays a role in the detoxification of hydrogen peroxide. [url:http://purl.obolibrary.org/obo/NCIT_C61062] catalase cat cat protein catalase ec 1.11.1.6 PR:P49913 MIO:01541 A cathelicidin antimicrobial peptide that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P49913] cathelicidin antimicrobial peptide 18 kDa cationic antimicrobial protein CAMP CAP-18 CAP18 FALL39 HSD26 hCAMP hCAP-18 NCIT:C16388 MIO:01542 Cathepsin D (412 aa, ~45 kDa) is encoded by the human CTSD gene. This protein is involved in proteolysis. [url:http://purl.obolibrary.org/obo/NCIT_C16388] cathepsin D cathepsin d cathepsin d (lysosomal aspartyl protease) ctsd ec 3.4.23.5 NCIT:C103232 MIO:01543 Cathepsin S (331 aa, ~37 kDa) is encoded by the human CTSS gene. This protein is involved in both proteolysis and immunity. [url:http://purl.obolibrary.org/obo/NCIT_C103232] cathepsin S cathepsin s cathepsin s precursor ctss ec 3.4.22.27 NCIT:C20909 MIO:01544 C-C motif chemokine 2 (99 aa, ~11 kDa) is encoded by the human CCL2 gene. This protein plays a role in monocyte and basophil chemotaxis. [url:http://purl.obolibrary.org/obo/NCIT_C20909] C-C motif chemokine 2 CCL2 HC11 MCAF MCP-1 monocyte chemoattractant protein 1 monocyte chemoattractant protein-1 monocyte chemotactic and activating factor monocyte chemotactic and activating protein monocyte chemotactic protein 1 monocyte chemotactic protein-1 monocyte secretory protein JE small inducible cytokine A2 small-inducible cytokine A2 NCIT:C25776 MIO:01545 C-C chemokine receptor type 1 (355 aa, ~41 kDa) is encoded by the human CCR1 gene. This protein plays a role in chemokine-mediated signaling. [url:http://purl.obolibrary.org/obo/NCIT_C25776] C-C chemokine receptor type 1 c-c chemokine receptor type 1 c-c ckr-1 cc-ckr-1 ccr-1 ccr1 ckr-1 cmkbr1 cmkr1 hm145 ld78 receptor macrophage inflammatory protein 1-alpha receptor macrophage inflammatory protein 1-alpha/rantes receptor macrophage inflammatory protein-1 alpha receptor mip-1 alpha-r mip-1alpha-r mip1ar rantes receptor rantes-r NCIT:C20481 MIO:01546 C-C motif chemokine 3 (92 aa, ~10 kDa) is encoded by the human CCL3 gene. This protein is involved in both the inhibition of HIV binding to C-C chemokine receptor type 5 and the regulation of neutrophil and monocyte chemotaxis. [url:http://purl.obolibrary.org/obo/NCIT_C20481] C-C motif chemokine 3 c-c motif chemokine 3 ccl3 chemokine (c-c motif) ligand 3 g0/g1 switch regulatory protein 19-1 ld78 ld78-alpha macrophage inflammatory protein 1-alpha mip-1 alpha mip-1-alpha mip-1a pat 464.1 sis-beta small inducible cytokine a3 small-inducible cytokine a3 stem cell inhibitor tonsillar lymphocyte ld78 alpha protein NCIT:C20483 MIO:01547 C-C motif chemokine 5 (91 aa, ~10 kDa) is encoded by the human CCL5 gene. This protein plays a role in both the release of histamine and chemoattraction of monocytes, memory T-helper cells and eosinophils. [url:http://purl.obolibrary.org/obo/NCIT_C20483] C-C motif chemokine 5 beta-chemokine rantes c-c motif chemokine 5 chemokine (c-c motif) ligand 5 d17s136e eocp eosinophil chemotactic cytokine mgc17164 rantes scya5 sis-delta sisd small inducible cytokine a5 small-inducible cytokine a5 t-cell rantes protein t-cell specific protein p288 t-cell specific rantes t-cell specific rantes protein t-cell-specific protein rantes tcp228 NCIT:C28731 MIO:01548 C-C motif chemokine 7 (99 aa, ~11 kDa) is encoded by the human CCL7 gene. This protein is involved in chemotaxis of monocytes and eosinophils. [url:http://purl.obolibrary.org/obo/NCIT_C28731] C-C motif chemokine 7 c-c motif chemokine 7 ccl7 fic marc mcp-3 mcp3 monocyte chemoattractant protein 3 monocyte chemotactic protein 3 nc28 scya7 small inducible cytokine a7 small-inducible cytokine a7 NCIT:C62460 MIO:01549 CCN family member 2 (349 aa, ~38kDa) is encoded by the human CCN2 gene. This protein plays a role in the promotion of proliferation and differentiation of chondrocytes and also mediates heparin- and divalent cation-dependent cell adhesion in many different cell types. [url:http://purl.obolibrary.org/obo/NCIT_C62460] CCN family member 2 ccn family member 2 ccn2 cellular communication network factor 2 connective tissue growth factor ctcf hypertrophic chondrocyte-specific protein 24 ibp-8 igf-binding protein 8 igfbp-8 insulin-like growth factor-binding protein 8 NCIT:C104073 MIO:01550 CD27 antigen (260 aa, ~29 kDa) is encoded by the human CD27 gene. This protein is involved in regulating B-cell activation, immunoglobulin synthesis, and apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C104073] CD27 antigen cd27 antigen cd27 molecule cd27l receptor t-cell activation antigen cd27 t-cell activation antigen s152 tumor necrosis factor receptor superfamily member 7 tumor necrosis factor receptor superfamily, member 7 NCIT:C106593 MIO:01551 CD63 antigen (238 aa, ~256 kDa) is encoded by the human CD63 gene. This protein is involved in signal transduction and may play a role in growth regulation. [url:http://purl.obolibrary.org/obo/NCIT_C106593] CD63 antigen cd63 antigen cd63 antigen (melanoma 1 antigen) granulophysin lysosomal-associated membrane protein 3 lysosome-associated membrane glycoprotein 3 melanoma-associated antigen me491 melanoma-associated antigen mla1 ocular melanoma-associated antigen tetraspanin-30 tspan-30 NCIT:C17387 MIO:01552 Cellular tumor antigen p53 (393 aa, ~44 kDa) is encoded by the human TP53 gene. This protein plays a role in the regulation of both the cell cycle and apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C17387] cellular tumor antigen p53 antigen ny-co-13 cellular tumor antigen p53 p53 p53 protein p53 tumor suppressor phosphoprotein p53 tp53 transformation-related protein 53 tumor protein p53 tumor suppressor p53 NCIT:C104139 MIO:01553 Ceruloplasmin (1065 aa, ~122 kDa) is encoded by the human CP gene. This protein is involved in iron homeostasis. [url:http://purl.obolibrary.org/obo/NCIT_C104139] ceruloplasmin ceruloplasmin cp ferroxidase PR:P36222 MIO:01554 A chitinase-3-like protein 1 that is encoded in the genome of human. [url:http://purl.obolibrary.org/obo/PR_P36222] chitinase-3-like protein 1 9 kDa synovial protein CGP-39 CHI3L1 GP-39 YKL-40 cartilage glycoprotein 39 NCIT:C40097 MIO:01555 Cholesteryl ester transfer protein (493 aa, ~55 kDa) is encoded by the human CETP gene. This protein is involved in cholesterol transport, metabolism, and homeostasis. [url:http://purl.obolibrary.org/obo/NCIT_C40097] cholesteryl ester transfer protein cetp cholesteryl ester transfer protein lipid transfer protein i plasma cholesteryl ester transfer protein NCIT:C45486 NCIT:C92289 UMLS:C0202207 UMLS:C0728810 MIO:01556 Cholinesterase (602 aa, ~68 kDa) is encoded by the human BCHE gene. This protein plays a role in choline metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C45486] cholinesterase BCHE CHE1 CHOLINES Choline Esterase II EC 3.1.1.8 Pseudocholinesterase Pseudocholinesterase E1 acylcholine acylhydrolase butyrylcholine esterase butyrylcholinesterase NCIT:C17284 PR:000005421 MIO:01557 Chromogranin-A (457 aa, ~51 kDa) is encoded by the human CHGA gene. This protein plays a role in the modulation of both blood pressure and pancreatic release of insulin. [url:http://purl.obolibrary.org/obo/NCIT_C17284] chromogranin-A CHGA CST SP-I catestatin chromogranin A parathyroid secretory protein 1 pituitary secretory protein I NCIT:C84432 MIO:01558 Clusterin (449 aa, ~52 kDa) is encoded by the human CLU gene. This protein may be involved in lipid metabolism, complement regulation and the initiation of apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C84432] clusterin aging-associated gene 4 protein apo-j apolipoprotein j cli clusterin complement cytolysis inhibitor complement lysis inhibitor complement-associated protein sp-40,40 ku70-binding protein 1 na1/na2 sulfated glycoprotein 2 testosterone-repressed prostate message 2 trpm-2 NCIT:C91335 MIO:01559 Coagulation factor V (2224 aa, ~252 kDa) is encoded by the human F5 gene. This protein plays a role in the coagulation cascade. Coagulation factor V has no activity until it is cleaved by thrombin into two chains, called coagulation factor V heavy chain and coagulation factor V light chain. The two chains are non-covalently bound in a complex, factor Va, which is a cofactor that enhances the enzymatic activity of coagulation factor Xa. [url:http://purl.obolibrary.org/obo/NCIT_C91335] coagulation factor V F5 PTC activated protein C cofactor factor V proaccelerin, labile factor NCIT:C16570 MIO:01560 Coagulation factor VII (466 aa, ~52 kDa) is encoded by the human F7 gene. This protein is involved in both binding to tissue factor and the initiation of blood coagulation. Coagulation factor VII is converted from a zymogen to an active protease through a single proteolytic cleavage by by factor Xa, factor XIIa, factor IXa, or thrombin. [url:http://purl.obolibrary.org/obo/NCIT_C16570] coagulation factor VII EC 3.4.21.21 F7 FVIIc eptacog alfa factor VII factor VII coagulant proconvertin serum prothrombin conversion accelerator SNOMED:73801006 MIO:01561 coagulation factor VIIa FVIIa activated factor VII factor VIIa PMID:14760323 SNOMED:75840004 MIO:01562 Activated factor XII (FXIIa) is involved in vascular injury and repair, participating in inflammation, thrombosis, and fibrinolysis. [url:https://pubmed.ncbi.nlm.nih.gov/14760323/] coagulation factor XIIa FXIIa activated factor 12 activated factor XII activity of blood coagulation factor XIII factor XIIa hageman factor (activated) PR:P03951 MIO:01563 A coagulation factor XI that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P03951] coagulation factor XI F11 FXI PTA hF11 plasma thromboplastin antecedent NCIT:C104219 MIO:01564 Coagulation factor XII (615 aa, ~68 kDa) is encoded by the human F12 gene. This protein is involved in blood coagulation and fibrinolysis. [url:http://purl.obolibrary.org/obo/NCIT_C104219] coagulation factor XII beta-factor xiia part 1 beta-factor xiia part 2 coagulation factor xii coagulation factor xiia heavy chain coagulation factor xiia light chain ec 3.4.21.38 f12 hageman factor PR:P00488 MIO:01565 A coagulation factor XIII A chain that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P00488] coagulation factor XIII A chain F13A F13A1 coagulation factor XIIIa hF13A1 protein-glutamine gamma-glutamyltransferase A chain transglutaminase A chain NCIT:C143055 MIO:01566 Collagen alpha-1(III) chain (1466 aa, ~139 kDa) is encoded by the human COL3A1 gene. This protein plays a role in connective tissue organization. [url:http://purl.obolibrary.org/obo/NCIT_C143055] collagen alpha-1(III) chain alpha-1 type 3 collagen alpha-1 type iii collagen alpha1 (iii) collagen collagen alpha-1(iii) chain collagen type 3 alpha 1 chain collagen type iii alpha 1 chain NCIT:C17792 MIO:01567 Collagen alpha-1(XVIII) chain (1754 aa, ~178 kDa) is encoded by the human COL18A1 gene. This protein is involved in extracellular matrix structure, closure of the neural tube and retinal development. [url:http://purl.obolibrary.org/obo/NCIT_C17792] collagen alpha-1(XVIII) chain col18a1 col18a1 protein collagen alpha-1(xviii) chain collagen alpha1 (xviii) collagen xviii (alpha 1) collagen, type xviii, alpha 1 PR:P12110 MIO:01568 A collagen alpha-2(VI) chain that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P12110] collagen alpha-2(VI) chain COL6A2 hCOL6A2 PR:Q9BXJ1 MIO:01569 A complement C1q tumor necrosis factor-related protein 1 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9BXJ1] complement C1q tumor necrosis factor-related protein 1 C1QTNF1 CTRP1 G protein-coupled receptor-interacting protein GIP UNQ310/PRO353 hC1QTNF1 PR:000050137 MIO:01570 A complement C3 acylation stimulating protein in human. UniProtKB:P01024, 672-747.|Category=organism-modification. [url:http://purl.obolibrary.org/obo/PR_000050137] complement C3 acylation stimulating protein PRO_0000419935 UniProtKB:P01024, 672-747 hC3/ASP NCIT:C128865 MIO:01571 Complement C4-A (1744 aa, ~193 kDa) is encoded by the human C4A gene. This protein plays a role in both host defense and inflammation. [url:http://purl.obolibrary.org/obo/NCIT_C128865] complement C4-A acidic c4 acidic complement c4 c3 and pzp-like alpha-2-macroglobulin domain-containing protein 2 c4a complement c4-a complement component 4a complement component 4s rodgers form of c4 PR:Q9NPY3 MIO:01572 A complement component C1q receptor that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9NPY3] complement component C1q receptor C1QR1 C1q/MBL/SPA receptor C1qR C1qR(p) C1qRp CD93 CDw93 MXRA4 complement component 1 q subcomponent receptor 1 hCD93 matrix-remodeling-associated protein 4 NCIT:C84439 MIO:01573 Complement receptor type 1 (2039 aa, ~224 kDa) is encoded by the human CR1 gene. This protein is involved in complement activation. [url:http://purl.obolibrary.org/obo/NCIT_C84439] complement receptor type 1 c3b/c4b receptor cd35 cd35 antigen complement receptor type 1 cr1 NCIT:C16473 MIO:01574 Creatine kinase B-type (381 aa, ~43 kDa) is encoded by the human CKB gene. This protein plays a role in both energy homeostasis and creatine metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C16473] creatine kinase B-type b-ck brain creatine kinase ckb creatine kinase b-type creatine kinase-b creatine kinase-b chain ec 2.7.3.2 PR:P23582 MIO:01575 A C-type natriuretic peptide that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P23582] C-type natriuretic peptide CNP2 NPPC hNPPC NCIT:C26209 MIO:01576 CX3C chemokine receptor 1 (355 aa, ~40 kDa) is encoded by the human CX3CR1 gene. This protein plays a role in cell adhesion, chemotaxis, cell defense response and signal transduction. [url:http://purl.obolibrary.org/obo/NCIT_C26209] CX3C chemokine receptor 1 beta chemokine receptor-like 1 c-x3-c ckr-1 chemokine (c-c) receptor-like 1 chemokine (c-x3-c motif) receptor 1 chemokine, cx3c motif, receptor 1 cmk-brl-1 cmk-brl1 cmkblr1 cx3c chemokine receptor 1 cx3cr1 cx3cr1 protein fractalkine receptor fractalkine receptor cx3cr1 g protein-coupled receptor 13 g protein-coupled receptor v28 g-protein coupled receptor 13 g-protein coupled receptor family 1 v28 NCIT:C17789 MIO:01577 C-X-C chemokine receptor type 4 (352 aa, ~40 kDa) is encoded by the human CXCR4 gene. This protein is involved in the stimulation of mitogenic signaling pathways, vascularization of the gastrointestinal tract and hematopoiesis. [url:http://purl.obolibrary.org/obo/NCIT_C17789] C-X-C chemokine receptor type 4 c-x-c chemokine receptor type 4 cd184 antigen chemokine (c-x-c motif) receptor 4 chemokine, cxc motif, receptor 4 cxc-r4 cxcr4 cxcr4 receptor fb22 fusin hm89 lap-3 lcr1 lestr leukocyte-derived seven transmembrane domain receptor leukocyte-derived seven-transmembrane-domain receptor lipopolysaccharide-associated protein 3 lps-associated protein 3 neuropeptide y receptor y3 sdf-1 receptor sdf1/pbsf receptor cxcr4 seven-transmembrane-segment receptor, spleen stromal cell-derived factor 1 receptor NCIT:C28756 MIO:01578 C-X-C motif chemokine 10 (98 aa, ~11 kDa) is encoded by the human CXCL10 gene. This protein is involved in chemotaxis of monocytes and T-lymphocytes. [url:http://purl.obolibrary.org/obo/NCIT_C28756] C-X-C motif chemokine 10 10 kda interferon gamma-induced protein c-x-c motif chemokine 10 c-x-c motif chemokine ligand 10 chemokine (c-x-c motif) ligand 10 cxcl10 gamma ip10 gamma-ip10 ifn-gamma-inducible protein-10 interferon gamma-induced factor interferon-alpha inducible protein 10 interferon-gamma induced protein interferon-gamma-induced factor interferon-gamma-inducible protein 10 interferon-inducible cytokine ip-10 ip-10 ip10 small inducible cytokine b10 small-inducible cytokine b10 NCIT:C104145 MIO:01579 C-X-C motif chemokine 16 (254 aa, ~28 kDa) is encoded by the human CXCL16 gene. This protein may be involved in lymphocyte chemotaxis. [url:http://purl.obolibrary.org/obo/NCIT_C104145] C-X-C motif chemokine 16 c-x-c motif chemokine 16 cxc chemokine ligand 16 cxcl16 scavenger receptor for phosphatidylserine and oxidized low density lipoprotein NCIT:C17586 MIO:01580 Cyclin-dependent kinase inhibitor 1C (316 aa, ~32 kDa) is encoded by the human CDKN1C gene. This protein is involved in the regulation of cell proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C17586] cyclin-dependent kinase inhibitor 1C beckwith-wiedemann syndrome protein cdkn1c cdkn1c protein cyclin-dependent kinase inhibitor 1c cyclin-dependent kinase inhibitor p57 kip2 protein p57-kip2 protein NCIT:C88359 MIO:01581 Cystatin-C (146 aa, ~16 kDa) is encoded by the human CST3 gene. This protein is involved in the inhibition of cysteine proteinases. [url:http://purl.obolibrary.org/obo/NCIT_C88359] cystatin-C CYSTATC Cys C Gamma-Trace Post-Gamma-Globulin cystatin C cystatin-3 neuroendocrine basic polypeptide NCIT:C106596 MIO:01582 Cytochrome B-245 heavy chain (570 aa, ~65 kDa) is encoded by the human CYBB gene. This protein plays a role in the microbicidal activity of phagocytes. [url:http://purl.obolibrary.org/obo/NCIT_C106596] cytochrome b-245 heavy chain cgd91-phox cybb cytochrome b(558) subunit beta cytochrome b-245 heavy chain cytochrome b558 subunit beta ec 1.6.3 gp91 phox gp91-1 gp91-phox heme-binding membrane glycoprotein gp91phox nadph oxidase 2 neutrophil cytochrome b 91 kda polypeptide p22 phagocyte b-cytochrome superoxide-generating nadph oxidase heavy chain subunit NCIT:C129851 MIO:01583 Cytochrome c (105 aa, ~12 kDa) is encoded by the human CYCS gene. This protein is involved in the transfer of electrons between complex III and complex IV of the mitochondrial electron transport chain. [url:http://purl.obolibrary.org/obo/NCIT_C129851] cytochrome c cyt c cytochrome c NCIT:C25948 MIO:01584 Cytochrome P450 2C19 (490 aa, ~56 kDa) is encoded by the human CYP2C19 gene. This protein is involved in steroid, terpenoid and drug metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C25948] cytochrome P450 2C19 (s)- limonene 6-monooxygenase (s)- limonene 7-monooxygenase cyp2c19 cypiic17 cypiic19 cytochrome p450 2c19 cytochrome p450, family 2, subfamily c, polypeptide 19 cytochrome p450, subfamily iic (mephenytoin 4-hydroxylase), polypeptide 19 cytochrome p450-11a cytochrome p450-254c ec 1.14.13.- ec 1.14.13.48 ec 1.14.13.49 ec 1.14.13.80 flavoprotein-linked monooxygenase mephenytoin 4'-hydroxylase mephenytoin 4-hydroxylase mephenytoin 4-prime-hydroxylase microsomal monooxygenase p450-11a p450-254c xenobiotic monooxygenase NCIT:C53621 MIO:01585 Deoxycytidylate deaminase (178 aa, ~20 kDa) is encoded by the human DCTD gene. This protein plays a role in the conversion of deoxycytidine to deoxyuridine. [url:http://purl.obolibrary.org/obo/NCIT_C53621] deoxycytidylate deaminase dcmp deaminase dctd protein deoxycytidine monophosphate deaminase deoxycytidylate deaminase PR:P24855 MIO:01586 A deoxyribonuclease-1 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P24855] deoxyribonuclease-1 DNASE1 DNL1 DNase I DRNI deoxyribonuclease I dornase alfa hDNASE1 NCIT:C91300 MIO:01587 Dipeptidyl peptidase 4 (766 aa, ~88 kDa) is encoded by the human DPP4 gene. This protein is involved in proteolytic regulation of T cell activation. [url:http://purl.obolibrary.org/obo/NCIT_C91300] dipeptidyl peptidase 4 adabp adcp-2 adenosine deaminase complexing protein 2 cd26 cd26 antigen dipeptidyl peptidase 4 dipeptidyl peptidase iv dipeptidyl-peptidase 4 dipeptidyl-peptidase iv dpp iv dpp4 ec 3.4.14.5 t-cell activation antigen cd26 tp103 PR:Q99543 MIO:01588 A DnaJ homolog subfamily C member 2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q99543] DnaJ homolog subfamily C member 2 DNAJC2 M-phase phosphoprotein 11 MPHOSPH11 MPP11 ZRF1 hDNAJC2 zuotin-related factor 1 PR:Q05923 MIO:01589 A dual specificity protein phosphatase 2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q05923] Dual specificity protein phosphatase 2 DUSP2 PAC1 dual specificity protein phosphatase PAC-1 hDUSP2 NCIT:C17406 MIO:01590 Endoglin (658 aa, ~71 kDa) is encoded by the human ENG gene. This protein plays a role in transforming growth factor receptor signaling. [url:http://purl.obolibrary.org/obo/NCIT_C17406] endoglin cd105 cd105 antigen end endoglin endoglin (osler-rendu-weber syndrome 1) eng hht1 orw orw1 transforming growth factor p receptor iii NCIT:C18046 MIO:01591 Endostatin (183 aa, ~20 kDa) is encoded by the human COL18A1 gene. This protein fragment is involved in the inhibition of both endothelial cell proliferation and blood vessel formation. [url:http://purl.obolibrary.org/obo/NCIT_C18046] endostatin col18a1 endostatin NCIT:C104089 MIO:01592 Endothelial cell-specific molecule 1 (184 aa, ~20 kDa) is encoded by the human ESM1 gene. This protein may play a role in the modulation of leukocyte-endothelial cell interactions. [url:http://purl.obolibrary.org/obo/NCIT_C104089] endothelial cell-specific molecule 1 ESM-1 ESM1 endocan PR:Q96AP7 MIO:01593 An endothelial cell-selective adhesion molecule that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q96AP7] endothelial cell-selective adhesion molecule ESAM UNQ220/PRO246 hESAM NCIT:C118584 MIO:01594 Endothelial protein C receptor (238 aa, ~27 kDa) is encoded by the human PROCR gene. This protein plays a role in the regulation of protein C-mediated blood coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C118584] endothelial protein C receptor activated protein c receptor apc receptor cd201 cd201 antigen cell cycle, centrosome-associated protein centrocyclin endothelial cell protein c receptor endothelial protein c receptor NCIT:C20429 MIO:01595 Erythropoietin (193 aa, ~21 kDa) is encoded by the human EPO gene. This protein plays a role in both erythropoiesis and the maintenance of red blood cell volume. [url:http://purl.obolibrary.org/obo/NCIT_C20429] erythropoietin epo epoetin erythrocyte colony stimulating factor erythropoeitin erythropoietin hematopoietin hemopoietin NCIT:C17491 MIO:01596 E-selectin (610 aa, ~67 kDa) is encoded by the human SELE gene. This protein is involved in leukocyte adhesion, migration and rolling. [url:http://purl.obolibrary.org/obo/NCIT_C17491] E-selectin cd62 antigen-like family member e cd62e cell adhesion molecule e-selectin e-selectin elam elam-1 elam1 endothelial adhesion molecule 1 endothelial leukocyte adhesion molecule 1 esel lecam2 leukocyte endothelial cell adhesion molecule 2 leukocyte-endothelial cell adhesion molecule 2 sele NCIT:C20974 PR:000007311 MIO:01597 Fatty acid-binding protein, heart (133 aa, ~15 kDa) is encoded by the human FABP3 gene. This protein plays a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. [url:http://purl.obolibrary.org/obo/NCIT_C20974] fatty acid-binding protein, heart FABP3 H-FABP M-FABP MDGI fatty acid binding protein 11 fatty acid binding protein, heart fatty acid-binding protein 3 fatty acid-binding protein 3, muscle fatty acid-binding protein, muscle and heart fatty acid-binding protein, skeletal muscle heart fatty acid-binding protein heart-type FABP heart-type fatty acid binding protein mammary-derived growth inhibitor muscle fatty acid-binding protein NCIT:C29617 MIO:01598 Fatty acid-binding protein, adipocyte (132 aa, ~15 kDa) is encoded by the human FABP4 gene. This protein is involved in binding to both long chain fatty acids and retinoic acid. [url:http://purl.obolibrary.org/obo/NCIT_C29617] fatty acid-binding protein, adipocyte a-fabp adipocyte lipid-binding protein adipocyte protein ap2 adipocyte-type fatty acid-binding protein afabp albp epididymis secretory protein li 104 fabp4 fatty acid-binding protein 4 fatty acid-binding protein 4, adipocyte fatty acid-binding protein, adipocyte NCIT:C117080 MIO:01599 Fermitin family homolog 3 (667 aa, ~76 kDa) is encoded by the human FERMT3 gene. This protein plays a role in hematopoietic cell adhesion, migration and proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C117080] fermitin family homolog 3 fermitin family homolog 3 fermt3 kindlin 3 kindlin-3 mig2-like protein unc-112 related protein 2 unc-112-related protein 2 NCIT:C16577 MIO:01600 An iron protein complex, containing up to 23% iron, formed by the union of ferric iron with apoferritin; it is found in the intestinal mucosa, spleen, bone marrow, reticulocytes, and liver, and regulates iron storage and transport from the intestinal lumen to plasma. [url:http://purl.obolibrary.org/obo/NCIT_C16577] ferritin PR:Q9UGM5 MIO:01601 A fetuin-B that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9UGM5] fetuin-B 16G2 FETUB Gugu fetuin-like protein IRL685 hFETUB NCIT:C32598 MIO:01602 A glycosylated elastic protein produced by the cleavage of fibrinogen by the protease thrombin during blood coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C32598] fibrin NCIT:C20547 MIO:01603 Fibroblast growth factor 2 (288 aa, ~31 kDa) is encoded by the human FGF2 gene. This protein plays a role in the regulation of cell proliferation, angiogenesis, and limb and nervous system development. [url:http://purl.obolibrary.org/obo/NCIT_C20547] fibroblast growth factor 2 basic fibroblast growth factor bfgf fgf-2 fgf2 fibroblast growth factor 2 hbgf-2 heparin-binding growth factor 2 prostatropin NCIT:C26127 MIO:01604 Fibroblast growth factor 21 (209 aa, ~22 kDa) is encoded by the human FGF21 gene. This protein may play a role in glucose metabolism in adipocytes. [url:http://purl.obolibrary.org/obo/NCIT_C26127] fibroblast growth factor 21 fgf-21 fgf21 fibroblast growth factor 21 NCIT:C104384 MIO:01605 Fibroblast growth factor 23 (251 aa, ~28 kDa) is encoded by the human FGF23 gene. This protein is involved in inhibition of renal tubular phosphate transport. [url:http://purl.obolibrary.org/obo/NCIT_C104384] fibroblast growth factor 23 fgf-23 fibroblast growth factor 23 phosphatonin tumor-derived hypophosphatemia inducing factor tumor-derived hypophosphatemia-inducing factor NCIT:C16581 MIO:01606 Fibronectin (2386 aa, ~263 kDa) is encoded by the human FN1 gene. This protein is involved in cell adhesion- and migration-dependent processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. [url:http://purl.obolibrary.org/obo/NCIT_C16581] fibronectin cig cold-insoluble globulin fibronectin fibronectin 1 fn fn1 fnz large external transformation-sensitive protein large, external, transformation-sensitive protein lets lets protein NCIT:C158412 MIO:01607 Fibronectin type III domain-containing protein 5 (212 aa, ~24 kDa) is encoded by the human FNDC5 gene. This protein plays a role in the cellular response to physical reactivity. [url:http://purl.obolibrary.org/obo/NCIT_C158412] fibronectin type III domain-containing protein 5 fibronectin type iii domain containing protein 5 fibronectin type iii domain-containing protein 5 fibronectin type iii repeat-containing protein 2 fndc5 PR:P23142 MIO:01608 A fibulin-1 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P23142] fibulin-1 FBLN1 FIBL-1 PP213 hFBLN1 PR:Q9UBX5 MIO:01609 A fibulin-5 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9UBX5] fibulin-5 DANCE FBLN5 FIBL-5 UNQ184/PRO210 UP50 developmental arteries and neural crest EGF-like protein hFBLN5 urine p50 protein NCIT:C153282 MIO:01610 Ficolin-2 (313 aa, ~34 kDa) is encoded by the human FCN2 gene. This protein is involved in calcuim-dependent binding to carbohydrates. [url:http://purl.obolibrary.org/obo/NCIT_C153282] ficolin-2 37 kda elastin-binding protein collagen/fibrinogen domain-containing protein 2 ebp-37 fcn2 ficolin 2 ficolin b ficolin-2 ficolin-b ficolin-beta hucolin l-ficolin serum lectin p35 NCIT:C131547 MIO:01611 Follistatin-related protein 1 (308 aa, ~35 kDa) is encoded by the human FSTL1 gene. This protein is involved in both signaling pathways and binding to heparin. [url:http://purl.obolibrary.org/obo/NCIT_C131547] follistatin-related protein 1 follistatin-like protein 1 follistatin-related protein 1 fstl1 NCIT:C20489 MIO:01612 Fractalkine (397 aa, ~42 kDa) is encoded by the human CX3CL1 gene. This protein is involved in chemotaxis of T-cells and monocytes. [url:http://purl.obolibrary.org/obo/NCIT_C20489] fractalkine c-x3-c motif chemokine 1 chemokine (c-x3-c motif) ligand 1 cx3c membrane-anchored chemokine cx3cl1 fractalkine neurotactin small inducible cytokine d1 small-inducible cytokine d1 MIO:01613 Furin (794 aa, ~87 kDa) is encoded by the human FURIN gene. This protein is involved in endopeptidase activity and the secretory pathway. [url:http://purl.obolibrary.org/obo/NCIT_C17902] furin PACE protein dibasic-processing enzyme NCIT:C104859 MIO:01614 Galectin-3 (250 aa, ~26 kDa) is encoded by the human LGALS3 gene. This protein plays a role in both antibody-mediated immunity and carbohydrate binding. [url:http://purl.obolibrary.org/obo/NCIT_C104859] galectin-3 35 kDa lectin CBP 35 GALBP Gal-3 IgE-binding protein L-31 LGALS3 carbohydrate-binding protein 35 galactose-specific lectin 3 galactoside-binding protein laminin-binding protein lectin L-29 mac-2 antigen NCIT:C26351 MIO:01615 Galectin-3-binding protein (585 aa, ~65 kDa) is encoded by the human LGALS3BP gene. This protein plays a role in the positive regulation of integrin-mediated cell adhesion. [url:http://purl.obolibrary.org/obo/NCIT_C26351] galectin-3-binding protein basement membrane autoantigen p105 galectin 3 binding protein galectin-3-binding protein l3 antigen lectin galactoside-binding soluble 3-binding protein lectin, galactoside-binding, soluble, 3 binding protein lgals3bp lgals3bp protein mac-2 bp mac-2-binding protein mac2-binding protein mac2bp serum protein 90k transport and golgi organization 10 homolog b tumor-associated antigen 90k NCIT:C94668 MIO:01616 Gastrin (101 aa, ~11 kDa) is encoded by the human GAST gene. This protein plays a role in the modulation of food digestion by the gastrointestinal system. [url:http://purl.obolibrary.org/obo/NCIT_C94668] gastrin gast gastrin MIO:01617 Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from the tissue-specific posttranslational processing of the proglucagon peptide. It is produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption.[url:https://en.wikipedia.org/wiki/Glucagon-like_peptide-1] glucagon-like peptide 1 GLP-1 PR:P43220 MIO:01618 A glucagon-like peptide 1 receptor that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P43220] glucagon-like peptide 1 receptor GLP-1 receptor GLP-1-R GLP-1R GLP1R hGLP1R NCIT:C127004 MIO:01619 Glutathione peroxidase 3 (226 aa, ~26 kDa) is encoded by the human GPX3 gene. This protein is involved in hydrogen peroxide and lipid peroxide detoxification. [url:http://purl.obolibrary.org/obo/NCIT_C127004] glutathione peroxidase 3 ec 1.11.1.9 extracellular glutathione peroxidase glutathione peroxidase 3 gpx-3 gpx-p gpx3 gshpx-3 gshpx-p plasma glutathione peroxidase PR:P11216 MIO:01620 Glycogen phosphorylase isoenzyme BB (abbreviation: GPBB) is an isoenzyme of glycogen phosphorylase. This isoform of the enzyme exists in cardiac (heart) and brain tissue. The enzyme is one of the "new cardiac markers" which are discussed to improve early diagnosis in acute coronary syndrome. A rapid rise in blood levels can be seen in myocardial infarction and unstable angina. [url:https://en.wikipedia.org/wiki/Glycogen_phosphorylase_isoenzyme_BB] glycogen phosphorylase, brain form GPBB glycogen phosphorylase BB glycogen phosphorylase isoenzyme BB NCIT:C101406 MIO:01621 Glypican-6 (555 aa, ~63 kDa) is encoded by the human GPC6 gene. This protein plays a role in the mediation of cell-protein interactions. [url:http://purl.obolibrary.org/obo/NCIT_C101406] glypican-6 glypican proteoglycan 6 glypican-6 NCIT:C104268 MIO:01622 Granzyme B (247 aa, ~28 kDa) is encoded by the human GZMB gene. This protein plays a role in the mediation of cell-dependent cytotoxicity. [url:http://purl.obolibrary.org/obo/NCIT_C104268] granzyme B c11 cathepsin g-like 1 ctla-1 ctsgl1 cytotoxic serine protease b cytotoxic t-lymphocyte proteinase 2 cytotoxic t-lymphocyte-associated serine esterase 1 ec 3.4.21.79 fragmentin fragmentin-2 granzyme 2 granzyme b granzyme-2 gzmb hlp human lymphocyte protein lymphocyte protease sect t-cell serine protease 1-3e NCIT:C34026 MIO:01623 Growth/differentiation factor 15 (308 aa, ~34 kDa) is encoded by the human GDF15 gene. This protein plays a role in both tissue differentiation and signal transduction. [url:http://purl.obolibrary.org/obo/NCIT_C34026] growth/differentiation factor 15 GDF-15 GDF15 MIC-1 MIC1 NAG-1 NAG1 NRG-1 NRG1 NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1 NSAID-activated gene 1 protein NSAID-activated protein 1 NSAID-regulated gene 1 protein NSAID-regulated protein 1 PDF PLAB PTGF-Beta PTGFB TGF-PL growth differentiation factor 15 macrophage inhibitory cytokine 1 macrophage inhibitory cytokine-1 macrophage-inhibiting cytokine 1 nonsteroidal anti-inflammatory drug-activated protein 1 placental TGF-Beta placental bone morphogenic protein prostate differentiation factor prostate-derived factor NCIT:C26328 MIO:01624 Growth/differentiation factor 8 (375 aa, ~43 kDa) is encoded by the human MSTN gene. This protein plays a role in the negative regulation of skeletal muscle growth. [url:http://purl.obolibrary.org/obo/NCIT_C26328] growth/differentiation factor 8 gdf-8 gdf8 growth/differentiation factor 8 myostatin MIO:01625 Binding free plasma hemoglobin, secreted haptoglobin prevents loss of iron through the kidneys, protects the kidneys from oxidative damage by hemoglobin (Hb), and makes hemoglobin accessible to degradative enzymes. Hp/Hb clearance appears to be mediated by the monocyte/macrophage scavenger receptor CD163. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, by allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. (UniProt) Although homologous to serine proteases, haptoglobin is missing all of the essential catalytic residues; therefore, it has no enzymatic activity. (UniProt)[url:http://purl.obolibrary.org/obo/NCIT_C37962] Haptoglobin (406 aa, ~45 kDa) is encoded by the human HP gene. This protein plays a role in tight junction disassembly, intestinal permeability, heme iron recycling, antimicrobial activity and the regulation of hydrogen peroxide catabolism. [url:http://purl.obolibrary.org/obo/NCIT_C37962] haptoglobin HP zonulin PR:P34932 MIO:01626 A heat shock 70 kDa protein 4 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P34932] heat shock 70 kDa protein 4 APG2 HSP70RY HSPA4 hHSPA4 heat shock 70-related protein APG-2 NCIT:C16671 MIO:01627 Heat shock protein beta-1 (205 aa, ~23 kDa) is encoded by the human HSPB1 gene. This protein is involved in protein denaturation and the cellular response to oxidative stress. [url:http://purl.obolibrary.org/obo/NCIT_C16671] heat shock protein beta-1 28 kda heat shock protein estrogen-regulated 24 kda protein heat shock 27 kda protein heat shock protein 27 heat shock protein beta-1 hsp 27 hsp27 hspb1 srp27 stress-responsive protein 27 NCIT:C43318 MIO:01628 Heme oxygenase 1 (288 aa, ~33 kDa) is encoded by the human HMOX1 gene. This protein is involved in heme metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C43318] heme oxygenase 1 ec 1.14.99.3 heme oxygenase (decyclizing) heme oxygenase 1 hmox1 ho1 NCIT:C26313 MIO:01629 Heparanase (543 aa, ~61 kDa) is encoded by the human HPSE gene. This protein plays a role in proteoglycan catabolism. [url:http://purl.obolibrary.org/obo/NCIT_C26313] heparanase ec 3.2.1.166 endo-glucoronidase heparanase heparanase-1 hpa1 hpse hpse protein NCIT:C113637 MIO:01630 Heparin cofactor 2 (499 aa, ~57 kDa) is encoded by the human SERPIND1 gene. This protein plays a role in the glycosaminoglycan-dependent inhibition of thrombin. [url:http://purl.obolibrary.org/obo/NCIT_C113637] heparin cofactor 2 hc-ii heparin cofactor 2 heparin cofactor ii hls2 leuserpin 2 leuserpin-2 protease inhibitor leuserpin-2 serpin d1 NCIT:C82875 MIO:01631 Hepatic triacylglycerol lipase (499 aa, ~56 kDa) is encoded by the human LIPC gene. This protein is involved in the metabolism of lipids. [url:http://purl.obolibrary.org/obo/NCIT_C82875] hepatic triacylglycerol lipase ec 3.1.1.3 hepatic lipase hepatic triacylglycerol lipase hl lipase member c lipc NCIT:C116608 MIO:01632 Hepatitis A virus cellular receptor 1 (359 aa, ~39 kDa) is encoded by the human HAVCR1 gene. This protein is involved in the modulation of asthma and allergic reactions. [url:http://purl.obolibrary.org/obo/NCIT_C116608] hepatitis A virus cellular receptor 1 havcr-1 hepatitis a virus cellular receptor 1 kidney injury molecule 1 kidney injury molecule-1 kim-1 t cell immunoglobin domain and mucin domain protein 1 t-cell immunoglobulin and mucin domain-containing protein 1 t-cell immunoglobulin and mucin domains-containing protein 1 t-cell immunoglobulin mucin receptor 1 t-cell membrane protein 1 tim tim-1 timd-1 NCIT:C20428 MIO:01633 Hepatocyte growth factor (728 aa, ~83 kDa) is encoded by the human HGF gene. This protein is involved in both the modulation of hepatocyte proliferation and growth factor receptor signaling in hepatocytes and many other cell types. [url:http://purl.obolibrary.org/obo/NCIT_C20428] hepatocyte growth factor fibroblast-derived tumor cytotoxic factor hepatocyte growth factor hepatopoietin a hgf hgf/sf lung fibroblast-derived mitogen scatter factor NCIT:C104274 MIO:01634 Hepcidin (84 aa, ~9 kDa) is encoded by the human HAMP gene. This protein is involved in antimicrobial activity and iron absorption and storage. [url:http://purl.obolibrary.org/obo/NCIT_C104274] hepcidin hamp hepcidin leap-1 liver-expressed antimicrobial peptide 1 pltr putative liver tumor regressor NCIT:C20328 PR:P09429 MIO:01635 High mobility group protein B1 (215 aa, ~25 kDa) is encoded by the human HMGB1 gene. This protein is involved in the regulation of both chromatin structure and DNA topology. HMGB1 is a very abundant and conserved 25-kD protein which plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221) [url:http://purl.obolibrary.org/obo/NCIT_C20328] high mobility group protein B1 HMG 1 HMG-1 HMG1 HMG3 HMGB1 SBP-1 amphoterin high-mobility group (nonhistone chromosomal) protein 1 high-mobility group box 1 nonhistone chromosomal protein HGM1 sulfoglucuronyl carbohydrate binding protein NCIT:C25186 MIO:01636 The smallest and densest lipoproteins, containing a high proportion of protein. They are synthesized in the liver as empty proteins and they pick up cholesterol and increase in size as they circulate through the bloodstream. Because HDL can remove cholesterol from the arteries, and transport it back to the liver for excretion, they are seen as "good" lipoproteins. high-density lipoprotein HDL NCIT:C20214 MIO:01637 Hypoxia-inducible factor 1-alpha (826 aa, ~93 kDa) is encoded by the human HIF1A gene. This protein plays a role in transcriptional regulation in response to hypoxia. [url:http://purl.obolibrary.org/obo/NCIT_C20214] hypoxia-inducible factor 1-alpha arnt interacting protein arnt-interacting protein basic-helix-loop-helix-pas protein mop1 bhlhe78 class e basic helix-loop-helix protein 78 hif-1 alpha hif-1-alpha hif-1alpha hif1a hypoxia-inducible factor 1, alpha subunit hypoxia-inducible factor 1-alpha hypoxia-inducible factor1alpha member of pas protein 1 member of pas superfamily 1 pas domain-containing protein 8 PR:Q9Y4L1 MIO:01638 A hypoxia up-regulated protein 1 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9Y4L1] hypoxia up-regulated protein 1 150 kDa oxygen-regulated protein 170 kDa glucose-regulated protein GRP-170 GRP170 HYOU1 ORP-150 ORP150 hHYOU1 PMID:15978102 MIO:01639 IgM antibody to endothelial protein C receptor IgM anti-EPCR IgM antibodies to endothelial protein C receptor PR:P01854 MIO:01640 An immunoglobulin heavy constant epsilon that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P01854] immunoglobulin heavy constant epsilon IGHE Ig epsilon chain C region Ig epsilon chain C region ND hIGHE NCIT:C176526 MIO:01641 Immunoglobulin heavy constant mu (453 aa, ~49 kDa) is encoded by the human IGHM gene. This protein plays a role in structure of membrane-bound and secreted immunoglobulins. [url:http://purl.obolibrary.org/obo/NCIT_C176526] immunoglobulin heavy constant mu ig mu chain c region ig mu chain c region bot ig mu chain c region gal ig mu chain c region ou ighm igm heavy chain constant region immunoglobulin heavy chain constant region mu immunoglobulin heavy chain mu constant region immunoglobulin heavy constant mu immunoglobulin mu chain PMID:24979051 MIO:01642 a mimic peptide (PMI-1) with high validity in preoperative prediction of PMI after CABG [PMID:24979051] inserted peptide sequence GVIMVIAVSCVF NCIT:C2271 MIO:01643 Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C2271] insulin ins insulin NCIT:C17505 PR:000008947 MIO:01644 Insulin-like growth factor-binding protein 1 (259 aa, ~28 kDa) is encoded by the human IGFBP1 gene. This protein is involved in cell migration and both insulin-like growth factor binding and signaling. [url:http://purl.obolibrary.org/obo/NCIT_C17505] insulin-like growth factor-binding protein 1 AFBP IBP-1 IGF binding protein 1 IGF-binding protein 1 IGFBP-1 IGFBP1 PP12 alpha-pregnancy-associated endometrial globulin amniotic fluid binding protein binding protein-25 binding protein-26 binding protein-28 growth hormone independent-binding protein placental protein 12 NCIT:C17509 MIO:01645 Insulin-like growth factor-binding protein 3 (291 aa, ~32 kDa) is encoded by the human IGFBP3 gene. This protein plays a role in insulin-like growth factor signaling, apoptosis promotion, and cell proliferation inhibition. [url:http://purl.obolibrary.org/obo/NCIT_C17509] insulin-like growth factor-binding protein 3 acid stable subunit of the 140 k igf complex binding protein 29 binding protein 53 growth hormone-dependent binding protein ibp-3 igf binding protein 3 igf-binding protein 3 igfbp-3 igfbp3 insulin-like growth factor binding protein 3 insulin-like growth factor-binding protein 3 NCIT:C17507 MIO:01646 Insulin-like growth factor-binding protein 4 (258 aa, ~28 kDa) is encoded by the human IGFBP4 gene. This protein plays a role in both insulin-like growth factor binding and downstream signal transduction. [url:http://purl.obolibrary.org/obo/NCIT_C17507] insulin-like growth factor-binding protein 4 ibp-4 igf binding protein 4 igf-binding protein 4 igfbp-4 igfbp4 insulin-like growth factor binding protein 4 insulin-like growth factor-binding protein 4 NCIT:C16743 MIO:01647 Insulin-like growth factor I (195 aa, ~22 kDa) is encoded by the human IGF1 gene. This protein may be involved in the regulation of glucose metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C16743] insulin-like growth factor I igf i igf-1 igf-i igf1 insulin-like growth factor 1 insulin-like growth factor i insulin-like growth factor-i mechano growth factor mgf somatomedin c somatomedin-c NCIT:C17373 MIO:01648 Integrin alpha-M (1152 aa, ~127 kDa) is encoded by the human ITGAM gene. This protein is involved in both leukocyte adhesion and the phagocytosis of complement coated particles. [url:http://purl.obolibrary.org/obo/NCIT_C17373] integrin alpha-M cd11 antigen-like family member b cd11b cd11b antigen cell surface glycoprotein mac-1 subunit alpha complement receptor type 3, alpha subunit cr-3 alpha chain integrin alpha m integrin alpha-m itgam leukocyte adhesion receptor mo1 mac1 alpha macrophage antigen alpha polypeptide mo1 alpha neutrophil adherence receptor neutrophil adherence receptor alpha-m subunit NCIT:C124078 MIO:01649 Intelectin-1 (313 aa, ~35 kDa) is encoded by the human ITLN1 gene. This protein is involved in the enhancement of insulin-dependent signaling. [url:http://purl.obolibrary.org/obo/NCIT_C124078] intelectin-1 endothelial lectin hl-1 galactofuranose-binding lectin intelectin intelectin 1 intelectin-1 intestinal lactoferrin receptor lactoferrin receptor omentin EFO:0004520 NCIT:C17304 MIO:01650 A soluble ICAM-1 measurement is the quantification of the ICAM-1 protein. ICAM-1 levels are associated with adverse cardiovascular events. [url:http://www.ebi.ac.uk/efo/EFO_0004520] intercellular adhesion molecule 1 CD54 CD54 Antigen Human Rhinovirus Receptor ICAM-1 ICAM1 Major Group Rhinovirus Receptor intercellular adhesion molecule-1 intracellular adhesion molecule-1 sICAM-1 soluble intercellular adhesion molecule-1 NCIT:C20496 MIO:01651 Interferon gamma (166 aa, ~19 kDa) is encoded by the human IFNG gene. This protein is involved in antiviral activity, macrophage activation, antiproliferative activity and immunopotentiation. [url:http://purl.obolibrary.org/obo/NCIT_C20496] interferon gamma gamma interferon gamma-interferon ifn-g ifn-ii ifng immune interferon interferon gamma interferon type ii interferon, gamma lfn-gamma type ii interferon NCIT:C98166 MIO:01652 Interleukin-1 receptor antagonist protein (177 aa, ~20 kDa) is encoded by the human IL1RN gene. This protein is involved in the inhibition of the interaction between interleukin-1 and its receptor. [url:http://purl.obolibrary.org/obo/NCIT_C98166] interleukin-1 receptor antagonist protein icil-1ra il-1ra il-1rn il1 inhibitor il1rn interleukin-1 receptor antagonist protein intracellular il-1 receptor antagonist type ii intracellular interleukin-1 receptor antagonist irap NCIT:C29751 MIO:01653 Interleukin-1 receptor-associated kinase 3 (596 aa, ~68 kDa) is encoded by the human IRAK3 gene. This protein plays a role in the negative regulation of toll-like receptor signaling [url:http://purl.obolibrary.org/obo/NCIT_C29751] interleukin-1 receptor-associated kinase 3 il-1 receptor-associated kinase m interleukin 1 receptor-associated kinase 3 interleukin 1 receptor-associated kinase m interleukin-1 receptor-associated kinase 3 interleukin-1 receptor-associated kinase m irak-3 irak-m irak3 irakm NCIT:C106011 MIO:01654 Interleukin-1 receptor-like 1 (556 aa, ~63 kDa) is encoded by the human IL1RL1 gene. This protein plays a role in binding interleukin-33 and immune response signaling. [url:http://purl.obolibrary.org/obo/NCIT_C106011] interleukin-1 receptor-like 1 il1rl1 interleukin 1 receptor-related protein interleukin-1 receptor-like 1 protein st2 NCIT:C38914 MIO:01655 Interleukin-1 receptor type 2 (398 aa, ~45 kDa) is encoded by the human IL1R2 gene. This protein plays a role in both interleukin-1 binding and the inhibition of signaling. [url:http://purl.obolibrary.org/obo/NCIT_C38914] interleukin-1 receptor type 2 antigen cdw121b cd121 antigen-like family member b cd121b cd121b antigen cdw121b il-1 type ii receptor il-1r-2 il-1r-beta il-1rt-2 il-1rt2 interleukin 1 receptor type ii interleukin-1 receptor beta interleukin-1 receptor beta type-ii interleukin-1 receptor type 2 interleukin-1 receptor type ii NCIT:C17073 MIO:01656 Interleukin-2 receptor subunit alpha (272 aa, ~31 kDa) is encoded by the human IL2RA gene. This protein plays a role in interleukin-2-dependent signaling. [url:http://purl.obolibrary.org/obo/NCIT_C17073] interleukin-2 receptor subunit alpha cd25 il-2 receptor il-2 receptor subunit alpha il-2-ra il-2r il-2r subunit alpha il2 receptor il2-ra il2r il2ra interleukin 2 receptor interleukin 2 receptor, alpha interleukin-2 receptor alpha chain interleukin-2 receptor subunit alpha low affinity interleukin 2 receptor p55 t-cell growth factor receptor tac antigen NCIT:C38921 MIO:01657 Interleukin-6 receptor subunit alpha (468 aa, ~52 kDa) is encoded by the human IL6R gene. This protein plays a role in regulation of the immune response, interleukin-6-mediated signaling, and hematopoiesis. [url:http://purl.obolibrary.org/obo/NCIT_C38921] interleukin-6 receptor subunit alpha cd126 antigen gp80 il-6 receptor subunit alpha il-6r il-6r 1 il-6r subunit alpha il-6r-alpha il-6ra il6r il6ra interleukin 6 receptor interleukin-6 receptor interleukin-6 receptor alpha chain interleukin-6 receptor alpha subunit interleukin-6 receptor subunit alpha membrane glycoprotein 80 NCIT:C26265 MIO:01658 Interleukin-6 receptor subunit beta (918 aa, ~104 kDa) is encoded by the human IL6ST gene. This protein is involved in cytokine receptor-mediated signal transduction. [url:http://purl.obolibrary.org/obo/NCIT_C26265] interleukin-6 receptor subunit beta cd130 cd130 antigen cdw130 gp130 gp130 transducer chain il-6 receptor subunit beta il-6r subunit beta il-6r-beta il-6rb il6st interleukin 6 signal transducer interleukin receptor beta chain interleukin-6 receptor subunit beta interleukin-6 signal transducer membrane glycoprotein 130 membrane glycoprotein gp130 oncostatin m receptor oncostatin-m receptor subunit alpha NCIT:C114390 MIO:01659 Kininogen-1 (644 aa, ~72 kDa) is encoded by the human KNG1 gene. This protein is involved in the positive regulation of fibrinolysis. [url:http://purl.obolibrary.org/obo/NCIT_C114390] kininogen-1 alpha-2-thiol proteinase inhibitor fitzgerald factor high molecular weight kininogen hmwk kininogen kininogen 1 kininogen-1 kng1 williams-fitzgerald-flaujeac factor NCIT:C98116 MIO:01660 Klotho (1012 aa, ~116 kDa) is encoded by the human KL gene. This protein is involved in signal transduction. [url:http://purl.obolibrary.org/obo/NCIT_C98116] Klotho ec 3.2.1.31 kl klotho PR:Q99538 MIO:01661 A legumain that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q99538] legumain LGMN PRSC1 asparaginyl endopeptidase hLGMN protease, cysteine 1 NCIT:C46081 MIO:01662 Leptin (167 aa, ~16 kDa) is encoded by the human LEP gene. This protein is secreted by adipocytes and plays a role in the regulation of both appetite and body fat stores. [url:http://purl.obolibrary.org/obo/NCIT_C46081] leptin obese protein obesity factor NCIT:C26349 MIO:01663 Leptin receptor (1165 aa, ~132 kDa) is encoded by the human LEPR gene. This protein plays a role in hormone binding, lipid metabolism, and lymphopoiesis. [url:http://purl.obolibrary.org/obo/NCIT_C26349] leptin receptor cd295 antigen hub219 lep-r lepr lepr protein leptin receptor ob receptor ob-r PR:P02750 MIO:01664 A leucine-rich alpha-2-glycoprotein that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P02750] leucine-rich alpha-2-glycoprotein LRG LRG1 hLRG1 NCIT:C26200 MIO:01665 Leucine-rich repeat neuronal protein 2 (713 aa, ~79 kDa) is encoded by the human LRRN2 gene. This protein may play a role in cell adhesion or ligand-mediated signal transduction. [url:http://purl.obolibrary.org/obo/NCIT_C26200] leucine-rich repeat neuronal protein 2 gac1 glioma amplification on chromosome 1 glioma amplified on chromosome 1 protein glioma amplified on chromosome 1 protein (leucine-rich) leucine rich and ankyrin repeats 1 leucine rich repeat neuronal 5 protein leucine-rich repeat neuronal protein 2 leucine-rich repeat neuronal protein 5 lrrn5 NCIT:C105867 MIO:01666 Lipopolysaccharide-binding protein (481 aa, ~53 kDa) is encoded by the human LBP gene. This protein plays a role in lipopolysaccharide binding. [url:http://purl.obolibrary.org/obo/NCIT_C105867] lipopolysaccharide-binding protein lbp lipopolysaccharide-binding protein lps-bp NCIT:C82022 MIO:01667 Lipoprotein(a) is a low-density lipoprotein variant containing a protein called apolipoprotein(B). Genetic and epidemiological studies have identified lipoprotein(a) as a risk factor for atherosclerosis and related diseases, such as coronary heart disease and stroke. [url:https://en.wikipedia.org/wiki/Lipoprotein(a)] lipoprotein(a) LPA Lp(a) lipoprotein a NCIT:C104616 MIO:01668 Lipoprotein lipase (475 aa, ~53 kDa) is encoded by the human LPL gene. This protein is involved in the metabolism of triglycerides. [url:http://purl.obolibrary.org/obo/NCIT_C104616] lipoprotein lipase 3.1.1.34 lipoprotein lipase lpl PR:P07195 MIO:01669 An L-lactate dehydrogenase B chain that is encoded in the genome of human.|Category=organism-gene. Requested by=PubChem. [url:http://purl.obolibrary.org/obo/PR_P07195] L-lactate dehydrogenase B chain LDH heart subunit LDH-B LDH-H LDHB hLDHB renal carcinoma antigen NY-REN-46 NCIT:C28467 PR:P14174 MIO:01670 Macrophage migration inhibitory factor (115 aa, ~12 kDa) is encoded by the human MIF gene. This protein is involved in the regulation of the innate immune response. [url:http://purl.obolibrary.org/obo/NCIT_C28467] macrophage migration inhibitory factor EC 5.3.2.1 EC 5.3.3.12 L-dopachrome isomerase L-dopachrome tautomerase MIF glycosylation-inhibiting factor phenylpyruvate tautomerase NCIT:C20437 MIO:01671 Macrophage colony-stimulating factor 1 (554 aa, ~60 kDa) is encoded by the human CSF1 gene. This protein is involved in in the regulation of survival, proliferation and differentiation of mononuclear phagocytes. [url:http://purl.obolibrary.org/obo/NCIT_C20437] macrophage colony-stimulating factor 1 colony stimulating factor 1 colony-stimulating factor 1 csf-1 csf1 m-csf macrophage colony stimulating factor macrophage colony-stimulating factor 1 mcsf NCIT:C88923 MIO:01672 Macrosialin (354 aa, ~37 kDa) is encoded by the human CD68 gene. This protein may be involved in both pathogen phagocytosis and macrophage targeting. [url:http://purl.obolibrary.org/obo/NCIT_C88923] macrosialin antigen cd68 cd68 cd68 antigen gp110 macrosialin NCIT:C116405 UMLS:C0024544 MIO:01673 A family of enzymes whose members reversibly catalyze the oxidation of malate to oxaloacetate using the reduction of NAD+ to NADH and are involved in multiple metabolic pathways. There are 2 proteins in this family, malate dehydrogenase, cytoplasmic and malate dehydrogenase, mitochondrial. [url:http://purl.obolibrary.org/obo/NCIT_C116405] malate dehydrogenase EC 1.1.1.37 L-malate dehydrogenase MDH NAD-L-malate dehydrogenase NAD-dependent malate dehydrogenase NAD-dependent malic dehydrogenase NAD-linked malate dehydrogenase NAD-malate dehydrogenase NAD-malic dehydrogenase NAD-specific malate dehydrogenase malate (NAD) dehydrogenase malic acid dehydrogenase malic dehydrogenase PR:P48740 MIO:01674 A mannan-binding lectin serine protease 1 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P48740] mannan-binding lectin serine protease 1 CRARF CRARF1 MASP-1 MASP1 PRSS5 Ra-reactive factor serine protease p100 RaRF complement factor MASP-3 complement-activating component of Ra-reactive factor hMASP1 mannose-binding lectin-associated serine protease 1 mannose-binding protein-associated serine protease serine protease 5 NCIT:C68581 PR:P11226 MIO:01675 Mannose-binding protein C (248 aa, ~26 kDa) is encoded by the human MBL2 gene. This protein plays a role in the initiation of targeted host defense mechanisms against pathogens by activating the complement pathway. [url:http://purl.obolibrary.org/obo/NCIT_C68581] mannose-binding protein C MBP MBP-C MBP1 collectin-1 hMBL2 mannan-binding protein mannose binding protein mannose-binding lectin NCIT:C39587 MIO:01676 Xanthine dehydrogenase/oxidase (1333 aa, ~146 kDa) is encoded by the human XDH gene. This protein is involved in purine degradation. [url:http://purl.obolibrary.org/obo/NCIT_C39587] xanthine dehydrogenase/oxidase ec 1.1.1.204 ec 1.1.3.22 xanthine dehydrogenase xanthine dehydrogenase/oxidase xanthine oxidase xanthine oxidoreductase xd xdh xo xor PR:Q9H239 MIO:01677 A matrix metalloproteinase-28 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9H239] matrix metalloproteinase-28 MMP-28 MMP25 MMP28 UNQ1893/PRO4339 epilysin hMMP28 NCIT:C178567 MIO:01678 A protein complex composed of five activated complement proteins that form a transmembrane pore in pathogen cell membranes. Formation of the complex is initiated by C5 convertase cleavage of complement C5 that yields C5b. C5b forms a complex with C6 and then C7; this initial complex has an exposed hydrophobic site that can insert into the pathogen's cell membrane. Then the trimeric C8 is recruited to the complex and the C5b-6-7-8 complex promotes the polymerization of 10-16 molecules of C9, which form the pore. If enough of these pores penetrate the cell membrane of the pathogen, the targeted cell will lyse and die. [url:http://purl.obolibrary.org/obo/NCIT_C178567] membrane attack complex C5B9 C5b-6-7-8-9 TCC complement C5b-9 complement C5b-9 complex membrane-attack complex terminal complement complex PR:P01033 MIO:01679 Metalloproteinase inhibitor 1 (207aa, ~28 kDa) is encoded by the human TIMP1 gene. This protein is involved in both erythropoiesis and metalloproteinase inhibition. [url:http://purl.obolibrary.org/obo/NCIT_C17543] metalloproteinase inhibitor 1 EPA TIMP-1 TIMP1 collagenase inhibitor erythroid potentiating activity erythroid potentiating activity, collagenase inhibitor erythroid-potentiating activity fibroblast collagenase inhibitor tissue inhibitor of matrix metalloproteinase-1 tissue inhibitor of metalloproteinases tissue inhibitor of metalloproteinases 1 tissue inhibitor of metalloproteinases-1 PR:P16035 MIO:01680 Metalloproteinase inhibitor 2 (220aa, ~24 kDa) is encoded by the human TIMP2 gene. This protein plays a role in metalloproteinase inhibition. [url:http://purl.obolibrary.org/obo/NCIT_C17542] metalloproteinase inhibitor 2 CSC-21K TIMP-2 TIMP2 tissue inhibitor of matrix metalloproteinase-2 tissue inhibitor of metalloproteinases 2 tissue inhibitor-of metalloproteinase-2 MIO:01681 Metalloproteinase inhibitor 4 (224 aa, ~26 kDa) is encoded by the human TIMP4 gene. This protein plays a role in the inhibition of matrix metalloproteinases. [url:http://purl.obolibrary.org/obo/NCIT_C124088] metalloproteinase inhibitor 4 TIMP-4 tissue inhibitor of matrix metalloproteinase-4 tissue inhibitor of metalloproteinase 4 tissue inhibitor of metalloproteinase-4 tissue inhibitor of metalloproteinases 4 NCIT:C17681 MIO:01682 Metalloproteinase inhibitor 3 (221aa, ~24 kDa) is encoded by the human TIMP3 gene. This protein is involved in metalloproteinase inhibition. [url:http://purl.obolibrary.org/obo/NCIT_C17681] metalloproteinase inhibitor 3 k222 expressed in degenerative retinas metalloproteinase inhibitor 3 mig-5 protein protein mig-5 timp-3 tissue inhibitor of metalloproteinase-3 tissue inhibitor of metalloproteinases 3 NCIT:C126961 MIO:01683 MHC class I polypeptide-related sequence A (383 aa, ~43 kDa) is encoded by the human MICA gene. This protein plays a role in the negative regulation of natural killer cells. [url:http://purl.obolibrary.org/obo/NCIT_C126961] MHC class I polypeptide-related sequence A mhc class i polypeptide-related sequence a mic-a mica stress inducible class i homolog EFO:0008468 NCIT:C172523 MIO:01684 mid-regional pro-atrial natriuretic peptide ANPPROMR MR-proANP MRproANP midregional pro atrial natriuretic peptide midregional pro-atrial natriuretic peptide PR:P20774 MIO:01685 A mimecan that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P20774] mimecan OGN OIF SLRR3A hOGN osteoglycin osteoinductive factor NCIT:C325 PR:Q8WXI7 MIO:01686 An antigen expressed by tissues derived from mullerian epithelium (tubal, endometrial and endocervical) or celomic epithelium (mesothelial cells of the pleura, pericardium and peritoneum). Although its biochemical nature has not been clearly defined, CA125 has been described as a glycosylated, high-molecular-weight protein that may be released from damaged cells. Measurable in plasma, CA125 is a sensitive, nonspecific tumor marker for ovarian cancer; as such it is much more useful for monitoring clinical responses to the treatment of ovarian cancer than for the diagnosis of ovarian cancer. Elevated plasma CA125 may occur in association with other malignancies and non-malignant gynecologic disorders. (NCI04) [url:http://purl.obolibrary.org/obo/NCIT_C325] mucin-16 CA-125 CA-125 antigen CA125 cancer antigen 125 carbohydrate antigen 125 NCIT:C17391 MIO:01687 Myc proto-oncogene protein (439 aa, ~49 kDa) is encoded by the human MYC gene. This protein plays a role in the regulation of transcription and cell proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C17391] myc proto-oncogene protein bhlhe39 c-myc protein class e basic helix-loop-helix protein 39 myc myc proto-oncogene protein myc transcription factor proto-oncogene c-myc transcription factor p64 NCIT:C17548 MIO:01688 Myeloblastin (256 aa, ~28 kDa) is encoded by the human PRTN3 gene. This protein is involved in the proteolysis of extracellular matrix proteins. [url:http://purl.obolibrary.org/obo/NCIT_C17548] myeloblastin acpa agp7 azurophil granule protein 7 c-anca c-anca antigen ec 3.4.21.76 leukocyte proteinase 3 mbt myeloblastin neutrophil proteinase 4 neutrophil serine proteinase np-4 p29 pr-3 pr3 proteinase 3 serine proteinase, neutrophil wegener autoantigen wegener granulomatosis autoantigen NCIT:C71145 MIO:01689 Myeloperoxidase (745 aa, ~84 kDa) is encoded by the human MPO gene. This protein is involved in the regulation of the innate host defense through the production of hypohalous acids. [url:http://purl.obolibrary.org/obo/NCIT_C71145] myeloperoxidase EC 1.11.1.7 MPO CLAO:0001255 MIO:01690 Motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. [ https://en.wikipedia.org/wiki/Myosin lagonzalezmo 2021-08-26 ] myosin NCIT:C138125 PR:Q14896 MIO:01691 Myosin-binding protein C, cardiac-type (1274 aa, ~141 kDa) is encoded by the human MYBPC3 gene. This protein is involved in cardiac muscle cell contraction. [url:http://purl.obolibrary.org/obo/NCIT_C138125] myosin-binding protein C, cardiac-type C-protein, cardiac muscle isoform MYBPC3 cMyBP-C cMyC cardiac MyBP-C cardiac myosin binding protein-C myosin-binding protein C myosin-binding protein C, cardiac PR:P05976 MIO:01692 A myosin light chain 1/3, skeletal muscle isoform that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P05976] myosin light chain 1/3, skeletal muscle isoform MLC1/MLC3 MLC1F/MLC3F MYL1 hMYL1 myosin light chain A1/A2 myosin light chain alkali 1/2 PR:P08590 MIO:01693 A myosin light chain 3 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P08590] myosin light chain 3 CMLC1 MLC-lV/sb MLC1SB MYL3 VLCl cardiac myosin light chain 1 hMYL3 myosin light chain 1, slow-twitch muscle B/ventricular isoform ventricular myosin alkali light chain ventricular myosin light chain 1 ventricular/slow twitch myosin alkali light chain PR:P10916 MIO:01694 A myosin regulatory light chain 2, ventricular/cardiac muscle isoform that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P10916] myosin regulatory light chain 2, ventricular/cardiac muscle isoform MLC-2 MLC-2s/v MLC-2v MLC2 MYL2 cardiac myosin light chain 2 hMYL2 myosin light chain 2, slow skeletal/ventricular muscle isoform ventricular myosin light chain 2 NCIT:C77204 MIO:01695 NACHT, LRR and PYD domains-containing protein 3 (1034 aa, ~118 kDa) is encoded by the human NLRP3 gene. This protein plays a role in the modulation of both inflammation and apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C77204] NACHT, LRR and PYD domains-containing protein 3 angiotensin/vasopressin receptor aii/avp-like cold autoinflammatory syndrome 1 protein cryopyrin nacht, lrr and pyd domains-containing protein 3 pyrin-containing apaf1-like protein 1 NCIT:C80115 MIO:01696 NAD-dependent protein deacetylase sirtuin-1 (747 aa, ~82 kDa) is encoded by the human SIRT1 gene. This protein may be involved in protein deacetylation. [url:http://purl.obolibrary.org/obo/NCIT_C80115] NAD-dependent protein deacetylase sirtuin-1 ec 3.5.1.- hsir2 hsirt1 nad-dependent deacetylase sirtuin-1 nad-dependent protein deacetylase sirtuin-1 regulatory protein sir2 homolog 1 sir2-like protein 1 sirt1 sirtuin type 1 PR:Q8N6T7 MIO:01697 An NAD-dependent protein deacetylase sirtuin-6 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q8N6T7] NAD-dependent protein deacetylase sirtuin-6 SIR2-like protein 6 SIR2L6 SIRT6 hSIRT6 regulatory protein SIR2 homolog 6 PR:O43847 MIO:01698 A nardilysin that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_O43847] nardilysin N-arginine dibasic convertase NRD convertase NRD-C NRD1 NRDC hNRDC nardilysin convertase NCIT:C74886 UMLS:C0201900 MIO:01699 Atrial natriuretic factor (28 aa, ~3 kDa) is encoded by the human NPPA gene. This protein is involved in both cardiac homeostasis and pregnancy. [url:http://purl.obolibrary.org/obo/NCIT_C139911] natriuretic peptides A ANP CDD NPPA atrial natriuretic factor prohormone atrial natriuretic peptide atrial natriuretic peptide prohormone atrial natruiretic factor atriopeptigen atriopeptin atriopeptins cardiodilatin EFO:0006920 NCIT:C74735 SNOMED:407059007 UMLS:C1095989 MIO:01700 Ventricular natriuretic peptide or brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume. [url:https://en.wikipedia.org/wiki/Ventricular_natriuretic_peptide] natriuretic peptides B B-type natriuretic peptide BNP brain natriuretic peptide ventricular natriuretic peptide NCIT:C16836 MIO:01701 Neprilysin (750 aa, ~86 kDa) is encoded by the human MME gene. This protein is involved in the metabolism of biologically active peptides. [url:http://purl.obolibrary.org/obo/NCIT_C16836] neprilysin antigen cd10 atriopeptidase calla cd10 cd10 antigen common acute lymphoblastic leukemia antigen common all antigen ec 3.4.24.11 enkephalinase membrane metalloendopeptidase mme nep neprilysin neutral endopeptidase sfe skin fibroblast elastase NCIT:C71452 MIO:01702 Neutrophil gelatinase-associated lipocalin (198 aa, ~23 kDa) is encoded by the human LCN2 gene. This protein may play a role in iron transport, apoptosis, and innate immunity. Neutrophil gelatinase-associated lipocalin can form a complex with the protease matrix metalloproteinase-9. Formation of this complex may effect the protease activity and inhibitor susceptibility of the enzyme. [url:http://purl.obolibrary.org/obo/NCIT_C71452] neutrophil gelatinase-associated lipocalin 25 kDa alpha-2-microglobulin-related subunit of MMP-9 NGAL lipocalin-2 migration-stimulating factor inhibitor oncogene 24p3 oncogenic lipocalin 24p3 p25 siderocalin LCN2 uterocalin NCIT:C104198 MIO:01703 Neutrophil elastase (267 aa, ~29 kDa) is encoded by the human ELANE gene. This protein plays a role in innate host defense and tissue remodeling. [url:http://purl.obolibrary.org/obo/NCIT_C104198] neutrophil elastase bone marrow serine protease ec 3.4.21.37 elane elastase 2 elastase 2, neutrophil elastase, neutrophil expressed granulocyte-derived elastase human leukocyte elastase leukocyte elastate medullasin neutrophil elastase pmn elastase polymorphonuclear elastase NCIT:C30138 MIO:01704 Nicotinamide phosphoribosyltransferase (491 aa, ~56 kDa) is encoded by the human NAMPT gene. This protein plays a role in both NAD biosynthesis and immunomodulation. [url:http://purl.obolibrary.org/obo/NCIT_C30138] nicotinamide phosphoribosyltransferase ec 2.4.2.12 namprtase nampt nicotinamide phosphoribosyltransferase pbef pre-b cell enhancing factor pre-b cell-enhancing factor pre-b-cell colony enhancing factor 1 pre-b-cell colony-enhancing factor pre-b-cell colony-enhancing factor 1 visfatin NCIT:C38571 MIO:01705 Nitric oxide synthase, endothelial (1203 aa, ~133 kDa) is encoded by the human NOS3 gene. This protein plays a role in the modulation of vascular smooth muscle relaxation, VEGF-induced angiogenesis and blood coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C38571] nitric oxide synthase, endothelial cnos constitutive nos ec 1.14.13.39 ec-nos ecnos endothelial nitric oxide synthase endothelial nitric oxide synthase 3 endothelial nos enos nitric oxide synthase 3 nitric oxide synthase, endothelial nos type iii nos3 nosiii NCIT:C139088 MIO:01706 Atrial natriuretic peptide (ANP) is produced primarily by the cardiac atria, being synthesized first as pre-proANP, with a final cleavage of proANP into the active ANP, with relatively short half-life, and the more stable N-terminal proANP (NT-proANP) with relatively long half-life. [url:https://pubmed.ncbi.nlm.nih.gov/33770445/] N-terminal proA-type natriuretic peptide ANPPRONT N-terminal atrial natriuretic peptide N-terminal fragment of proA-type natriuretic peptide N-terminal fragments of natriuretic peptides N-terminal pro-atrial natriuretic peptide NT proANP II NT-ANP NT-pro-ANP NT-proANP Pro-NPPA ProANP EFO:0004745 NCIT:C88524 MIO:01707 The N-terminal prohormone of brain natriuretic peptide (NT-proBNP or BNPT) is a prohormone with a 76 amino acid N-terminal inactive protein that is cleaved from the molecule to release brain natriuretic peptide. [url:https://en.wikipedia.org/wiki/N-terminal_prohormone_of_brain_natriuretic_peptide] N-terminal prohormone of brain natriuretic peptide N-Terminal Fragment Brain Natriuretic Protein N-Terminal Fragment of Brain Natriuretic Protein N-Terminal Fragment of Prohormone Brain Natriuretic Peptide N-terminal brain natriuretic peptide N-terminal pro-brain natriuretic peptide N-terminal prohormone of brain natriuretic peptide NT-pro-BNP NT-proBNP NT-proBNP measurement NCIT:C94300 MIO:01708 Nuclear factor NF-kappa-B p105 subunit (968 aa, ~105 kDa) is encoded by the human NFKB1 gene. This protein is involved in the mediation of signal transduction, the regulation of apoptosis and the modulation of transcription. [url:http://purl.obolibrary.org/obo/NCIT_C94300] nuclear factor NF-kappa-B p105 subunit dna-binding factor kbf1 ebp-1 nuclear factor nf-kappa-b p105 subunit nuclear factor of kappa light polypeptide gene enhancer in b-cells 1 PR:P80303 MIO:01709 A nucleobindin-2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P80303] nucleobindin-2 DNA-binding protein NEFA NEFA NUCB2 epididymis secretory protein Li 109 gastric cancer antigen Zg4 hNUCB2 prepronesfatin NCIT:C46082 MIO:01710 Osteopontin (314 aa, ~35 kDa) is encoded by the human SPP1 gene. This protein is involved in the regulation of both tissue mineralization and cell-cell signaling. [url:http://purl.obolibrary.org/obo/NCIT_C46082] osteopontin bone sialoprotein 1 nephropontin osteopontin secreted phosphoprotein 1 spp-1 urinary stone protein uropontin SNOMED:259562001 MIO:01711 oxidized low density lipoprotein OxLDL ox-LDL oxidised low-density lipoprotein oxidised low-density lipoproteins oxidized LDL oxidized low-density lipoprotein xidized low-density lipoproteins PR:000011634 MIO:01712 A protein that is a translation product of the human OLR1 gene or a 1:1 ortholog thereof. [url:http://purl.obolibrary.org/obo/PR_000011634] oxidized low-density lipoprotein receptor 1 C-type lectin domain family 8 member A LOX-1 OLR1 Ox-LDL receptor 1 lectin-like oxLDL receptor 1 lectin-like oxidized LDL receptor 1 lectin-like oxidized low-density lipoprotein receptor-1 lectin-type oxidized LDL receptor 1 PR:000012270 MIO:01713 A protein that is a translation product of the human PAPPA gene or a 1:1 ortholog thereof. [url:http://purl.obolibrary.org/obo/PR_000012270] pappalysin-1 EC 3.4.24.79 IGF-dependent IGFBP-4 protease IGFBP-4ase PAPP-A PAPPA insulin-like growth factor-dependent IGF-binding protein 4 protease pregnancy-associated plasma protein A NCIT:C41027 MIO:01714 Parathyroid hormone (115 aa, ~13 kDa) is encoded by the human PTH gene. This protein is involved in the modulation of calcium ion and phosphate concentration in the blood. [url:http://purl.obolibrary.org/obo/NCIT_C41027] parathyroid hormone parathormone parathyrin parathyroid hormone parathyroid hormone 1 prepro-pth preproparathyroid hormone pth NCIT:C119682 MIO:01715 Pentraxin-related protein PTX3 (381 aa, ~42 kDa) is encoded by the human PTX3 gene. This protein is involved in both inflammation and complement recognition of pathogens. [url:http://purl.obolibrary.org/obo/NCIT_C119682] pentraxin-related protein PTX3 TNF alpha-induced protein 5 TSG-14 pentraxin 3 pentraxin-3 tumor necrosis factor alpha-induced protein 5 tumor necrosis factor-inducible gene 14 protein tumor necrosis factor-inducible protein TSG-14 NCIT:C104812 MIO:01716 Peptide YY (97 aa, ~11 kDa) is encoded by the human PYY gene. This protein is involved in hormone signaling to regulate gastrointestinal processes. [url:http://purl.obolibrary.org/obo/NCIT_C104812] peptide YY peptide tyrosine tyrosine peptide yy pyy pyy-i PR:O75594 MIO:01717 A peptidoglycan recognition protein 1 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_O75594] peptidoglycan recognition protein 1 PGLYRP PGLYRP1 PGRP PGRP-S SBBI68 TNFSF3L UNQ639/PRO1269 hPGLYRP1 peptidoglycan recognition protein short NCIT:C156929 MIO:01718 Peptidyl-prolyl cis-trans isomerase A (165 aa, ~18 kDa) is encoded by the human PPIA gene. This protein plays a role in cyclosporin-mediated immunosuppression, HIV virion assembly and protein folding. [url:http://purl.obolibrary.org/obo/NCIT_C156929] peptidyl-prolyl cis-trans isomerase A cyclophilin a cyclosporin a-binding protein ec 5.2.1.8 epididymis secretory sperm binding protein li 69p peptidyl-prolyl cis-trans isomerase a peptidyl-prolyl isomerase a peptidylprolyl isomerase a ppia ppiase a rotamase a NCIT:C116428 MIO:01719 Perilipin-2 (437 aa, ~48 kDa) is encoded by the human PLIN2 gene. This protein plays a role in cellular lipid storage [url:http://purl.obolibrary.org/obo/NCIT_C116428] perilipin-2 adipophilin adipose differentiation-related protein adrp perilipin-2 plin2 NCIT:C101424 MIO:01720 Periostin (836 aa, ~93 kDa) is encoded by the human POSTN gene. This protein plays a role in cell adhesion. [url:http://purl.obolibrary.org/obo/NCIT_C101424] periostin osf-2 osteoblast-specific factor 2 periodontal ligament-specific periostin periostin pn NCIT:C116295 MIO:01721 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (798 aa, ~91 kDa) is encoded by the human PPARGC1A gene. This protein plays a role in the regulation of gene transcription. [url:http://purl.obolibrary.org/obo/NCIT_C116295] peroxisome proliferator-activated receptor gamma coactivator 1-alpha l-pgc-1alpha ligand effect modulator 6 ligand effect modulator-6 peroxisome proliferator-activated receptor gamma coactivator 1 alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha pgc-1-alpha ppar-gamma coactivator 1 ppar-gamma coactivator 1-alpha ppargc-1-alpha ppargc1a NCIT:C18181 MIO:01722 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (403 aa, ~47 kDa) is encoded by the human PTEN gene. This protein plays a role in signaling and as both a dual-specificity phosphoprotein phosphatase and a lipid phosphatase. [url:http://purl.obolibrary.org/obo/NCIT_C18181] phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN ec 3.1.3.16 ec 3.1.3.48 ec 3.1.3.67 mitochondrial phosphatase and tensin protein alpha mitochondrial ptenalpha mutated in multiple advanced cancers 1 phosphatase and tensin homolog phosphatase and tensin-like protein phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten pten pten tyrosine phosphatase NCIT:C129389 MIO:01723 A family of enzymes that catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate. [url:http://purl.obolibrary.org/obo/NCIT_C129389] phosphoglucomutase alpha-d-glucose 1,6-phosphomutase ec 5.4.2.2 glucose phosphomutase pgm phosphoglucomutase phosphoglucose mutase NCIT:C104973 MIO:01724 Phospholipase A2 (148 aa, ~16 kDa) is encoded by the human PLA2G1B gene. This protein plays a role in fatty acid metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C104973] phospholipase A2 group ib phospholipase a2 phosphatidylcholine 2-acylhydrolase 1b phospholipase a2 phospholipase a2 group ib pla2g1b NCIT:C34063 MIO:01725 Phospholipase A2, membrane associated (144 aa, ~16 kDa) is encoded by the human PLA2G2A gene. This protein plays a role in the metabolism of phospholipids. [url:http://purl.obolibrary.org/obo/NCIT_C34063] phospholipase A2, membrane associated giic spla2 group iia phospholipase a2 membrane associated phospholipase a2 non-pancreatic secretory phospholipase a2 nps-pla2 phosphatidylcholine 2-acylhydrolase phosphatidylcholine 2-acylhydrolase 2a phospholipase a2 group iia phospholipase a2 polypeptide b phospholipase a2, group iia phospholipase a2, membrane associated pla2b pla2g2a pla2l pla2s plas1 NCIT:C116410 MIO:01726 ATP-binding cassette sub-family A member 1 (2261 aa, ~254 kDa) is encoded by the human ABCA1 gene. This protein plays a role in intracellular cholesterol transport. [url:http://purl.obolibrary.org/obo/NCIT_C116410] phospholipid-transporting ATPase ABCA1 abc transporter 1 abc-1 abca1 atp binding cassette subfamily a member 1 atp-binding cassette 1 atp-binding cassette sub-family a member 1 atp-binding cassette transporter 1 atp-binding cassette transporter a1 cholesterol efflux regulatory protein ec 7.6.2.1 phospholipid-transporting atpase abca1 NCIT:C28666 MIO:01727 Placenta growth factor (221 aa, ~25 kDa) is encoded by the human PGF gene. This protein is involved in both angiogenesis and the positive regulation of endothelial cell growth. [url:http://purl.obolibrary.org/obo/NCIT_C28666] placenta growth factor isoform plgf-3 pgf placenta growth factor placental growth factor placental growth factor-like plgf plgf-2 plgf-203 NCIT:C17324 MIO:01728 Plasma serine protease inhibitor (406 aa, ~46 kDa) is encoded by the human SERPINA5 gene. This protein is involved in the regulation of serine proteinases, spermatogenesis and fusion of sperm with the plasma membrane of an egg. [url:http://purl.obolibrary.org/obo/NCIT_C17324] plasma serine protease inhibitor acrosomal serine protease inhibitor alpha-1 antiproteinase antitrypsin pai-3 planh3 plasma serine protease inhibitor plasminogen activator inhibitor iii plasminogen activator inhibitor-3 proci protein c inhibitor serine or cysteine proteinase inhibitor clade a member 5 serpin a5 serpina5 NCIT:C129410 MIO:01729 A protein complex comprised of the serine proteinase plasmin irreversibly bound to its corresponding serine proteinase inhibitor protein (SERPIN) alpha-2-antiplasmin. [url:http://purl.obolibrary.org/obo/NCIT_C129410] plasmin-antiplasmin complex PAP plasmin-antiplasmin complex plasmin/alpha-2-antiplasmin complex plasmin/antiplasmin complex NCIT:C16994 MIO:01730 Plasminogen (810 aa, ~91 kDa) is encoded by the human PLG gene. This protein is involved in fibrinolysis, platelet activation and tissue remodeling. [url:http://purl.obolibrary.org/obo/NCIT_C16994] plasminogen ec 3.4.21.7 fibrinase precursor fibrinolysin precursor plasmin precursor plasminogen plg plmn thrombolysin precursor EFO:0004792 NCIT:C16947 PMID:33620437 MIO:01731 Plasminogen Activator Inhibitor-1 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators. PAI1 shows structural similarities to angiotensinogen, alpha-1-antitrypsin, and antithrombin III and also regulates motility through the interaction of vitronectin with its receptor, integrin alpha-V-beta-3. [url:http://purl.obolibrary.org/obo/NCIT_C16947] plasminogen activator inhibitor 1 Endothelial Plasminogen Activator Inhibitor Nexin PAI-1 PAI1 PLANH1 Plasminogen Activator Inhibitor 1 Plasminogen Activator Inhibitor Type 1 Plasminogen Activator Inhibitor-1 SERPINE1 Serine or Cysteine Proteinase Inhibitor Clade E Member 1 Serpin E1 SNOMED:121224003 MIO:01732 plasminogen activator inhibitor-1 antigen PAI-1 antigen PAI1AG plasminogen Activator Inhibitor-1 AG NCIT:C122066 MIO:01733 Platelet-activating factor acetylhydrolase (441 aa, ~50 kDa) is encoded by the human PLA2G7 gene. This protein is involved in platelet-activating factor metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C122066] platelet-activating factor acetylhydrolase 1-alkyl-2-acetylglycerophosphocholine esterase 2-acetyl-1-alkylglycerophosphocholine esterase ec 3.1.1.47 group-viia phospholipase a2 gviia-pla2 ldl-associated phospholipase a2 ldl-pla(2) lipoprotein-associated phospholipase a2 paf 2-acylhydrolase paf acetylhydrolase pla2g7 platelet-activating factor acetylhydrolase NCIT:C20810 MIO:01734 Platelet basic protein (128 aa, ~14 kDa) is encoded by the human PPBP gene. This protein is involved in platelet activation, chemotaxis, cytokine receptor binding and anti-bacterial activity. [url:http://purl.obolibrary.org/obo/NCIT_C20810] platelet basic protein c-x-c motif chemokine 7 cxc chemokine ligand 7 ldgf leukocyte-derived growth factor macrophage-derived growth factor mdgf pbp platelet basic protein ppbp pro-platelet basic protein small inducible cytokine subfamily b, member 7 small-inducible cytokine b7 thrombocidin 1 thrombocidin 2 NCIT:C128285 MIO:01735 A disulfide-linked homodimeric protein complex comprised of 2 platelet-derived growth factor subunit A proteins. This dimeric growth factor binds to a homodimeric receptor comprised of two platelet-derived growth factor receptor alpha proteins. Ligand binding activates the intrinsic tyrosine-protein kinase activity of the receptor complex and initiates signal transduction pathways. [url:http://purl.obolibrary.org/obo/NCIT_C128285] platelet-derived growth factor-AA pdgf-aa platelet-derived growth factor-aa NCIT:C30162 MIO:01736 Platelet-derived growth factor subunit A (211 aa, ~24 kDa) is encoded by the human PDGFA gene. This protein plays a role in the regulation of chemotaxis, cell migration, cell survival, cell proliferation, and embryonic development. [url:http://purl.obolibrary.org/obo/NCIT_C30162] platelet-derived growth factor subunit A pdgf a-chain pdgf subunit a pdgf-1 pdgfa platelet-derived growth factor a chain platelet-derived growth factor alpha platelet-derived growth factor alpha chain platelet-derived growth factor alpha polypeptide platelet-derived growth factor subunit a platelet-derived growth factor, a chain NCIT:C17402 MIO:01737 Platelet endothelial cell adhesion molecule (738 aa, ~83 kDa) is encoded by the human PECAM1 gene. This protein is involved in leukocyte transendothelial migration and angiogenesis. [url:http://purl.obolibrary.org/obo/NCIT_C17402] platelet endothelial cell adhesion molecule cd31 antigen endocam gpiia' peca1 pecam pecam-1 pecam1 platelet and endothelial cell adhesion molecule 1 platelet endothelial cell adhesion molecule platelet endothelial cell adhesion molecule-1 platelet/endothelial cell adhesion molecule 1 NCIT:C20811 MIO:01738 Platelet factor 4 (101 aa, ~11 kDa) is encoded by the human PF4 gene. This protein is involved in the negative regulation of endothelial cell proliferation, the chemotaxis of neutrophils and monocytes and the positive regulation of blood coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C20811] platelet factor 4 c-x-c motif chemokine 4 chemokine (c-x-c motif) ligand 4 cxcl4 iroplact oncostatin-a pf4 platelet factor 4 platelet factor-4 small inducible cytokine b4 small inducible cytokine subfamily b, member 4 small-inducible cytokine b4 NCIT:C18400 MIO:01739 Platelet glycoprotein 4 (472 aa, ~53 kDa) is encoded by the human CD36 gene. This protein is involved in blood coagulation, fatty acid binding, and cell adhesion. [url:http://purl.obolibrary.org/obo/NCIT_C18400] platelet glycoprotein 4 cd36 cd36 antigen cluster determinant 36 csvtcg-specific receptor csvtcg-specific tsp-1 receptor cysteine-serine-valine-threonine-cysteine-glycine specific tsp-1 receptor fat fatty acid translocase glycoprotein iiib gp iiib gp iv gpiiib gpiv leukocyte differentiation antigen cd36 pas-4 pas-4 protein platelet collagen receptor platelet glycoprotein 4 platelet glycoprotein iv scavenger receptor class b member 3 thrombospondin receptor NCIT:C126557 MIO:01740 Platelet glycoprotein V (560 aa, ~61 kDa) is encoded by the human GP5 gene. This protein is involved in von Willebrand factor binding. [url:http://purl.obolibrary.org/obo/NCIT_C126557] platelet glycoprotein V cd42d cd42d antigen glycoprotein 5 gp v gp-v gpv platelet glycoprotein 5 platelet glycoprotein v PR:P20742 MIO:01741 A pregnancy zone protein that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P20742] pregnancy zone protein C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6 CPAMD6 PZP hPZP PR:000050392 MIO:01742 A CD14 molecule isoform 1, signal peptide removed form that has been cleaved by plasma proteases to yield a soluble 13kD N-terminal fragment in human.|Category=organism-modification. Note: The cleavage position indicated in [PMID:21740312] is based on a synthetic construct; the true point of cleavage is unknown. It is believed that presepsin is derived from a membrane-bound precursor as opposed to a secreted form [PMID:16258819]. [url:http://purl.obolibrary.org/obo/PR_000050392] presepsin P-SEP PSEP hPSEP sCD14-ST soluble CD14 subtype soluble cluster of differentiation 14 subtype NCIT:C173465 MIO:01743 Procalcitonin (116 aa, ~13 kDa) is encoded by the human CALCA gene. This protein plays a role in sepsis. [url:http://purl.obolibrary.org/obo/NCIT_C173465] procalcitonin Pro-CALCA NCIT:C116020 MIO:01744 This polypeptide is comprised of the carboxy-terminal portions of procollagen, which are proteolytically removed by bone morphogenetic protein 1 during the intracellular formation of type I collagen fibrils. Increased plasma or serum concentrations of these peptides are associated with both fibrillogenesis of type I collagen and bone formation. [url:http://purl.obolibrary.org/obo/NCIT_C116020] procollagen type I C-terminal peptide collagen type 1 c-terminal propeptide collagen type i c-terminal propeptide p1cp picp procollagen type 1 c-terminal peptide procollagen type i c-terminal peptide NCIT:C116963 MIO:01745 A polypeptide comprised of the amino-terminal portions of procollagen, which are proteolytically removed during the intracellular formation of type I collagen fibrils. Increased plasma or serum concentrations of these peptides are associated with both fibrillogenesis of type I collagen and bone formation. [url:http://purl.obolibrary.org/obo/NCIT_C116963] procollagen type I N-terminal peptide amino-terminal propeptide of type 1 procollagen amino-terminal propeptide of type i procollagen p1np pinp procollagen type 1 amino-terminal peptide procollagen type 1 n-terminal peptide procollagen type i amino-terminal peptide procollagen type i n-terminal peptide type 1 procollagen amino-terminal peptide type 1 procollagen n-terminal peptide type i procollagen amino-terminal peptide type i procollagen n-terminal peptide NCIT:C126496 MIO:01746 Proenkephalin-A (267 aa, ~31 kDa) is encoded by the human PENK gene. This protein is involved in opioid receptor signaling. [url:http://purl.obolibrary.org/obo/NCIT_C126496] proenkephalin-A preproenkephalin preproenkephalin a preproenkephalin-a proenkephalin proenkephalin a proenkephalin-a NCIT:C125446 MIO:01747 Profilin-1 (140 aa, ~15 kDa) is encoded by the human PFN1 gene. This protein plays a role in the modulation of actin polymerization. [url:http://purl.obolibrary.org/obo/NCIT_C125446] profilin-1 epididymis tissue protein li 184a profilin i profilin-1 profilin-i NCIT:C118380 MIO:01748 Proheparin-binding EGF-like growth factor (208 aa, ~23 kDa) is encoded by the human HBEGF gene. This protein plays a role in both heart valve formation and mitogenesis for fibroblasts and smooth muscle cells. [url:http://purl.obolibrary.org/obo/NCIT_C118380] proheparin-binding EGF-like growth factor pro-hb-egf proheparin-binding egf-like growth factor NCIT:C113517 MIO:01749 Proinsulin (110 aa, ~12 kDa) is encoded by the human INS gene. This protein plays a role in the modulation of glucose metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C113517] proinsulin ins insulin precursor proinsulin NCIT:C116765 MIO:01750 Pro-interleukin-16 (1332 aa, ~142 kDa) is encoded by the human IL16 gene. This protein is involved in both transcriptional repression and cytokine signaling. [url:http://purl.obolibrary.org/obo/NCIT_C116765] pro-interleukin-16 npro-il-16 pro-il-16 pro-interleukin-16 prointerleukin 16 prointerleukin-16 NCIT:C778 MIO:01751 Prolactin (227 aa, ~26 kDa) is encoded by the human PRL gene. This protein is involved in the promotion of lactation in the mammary gland. [url:http://purl.obolibrary.org/obo/NCIT_C778] prolactin decidual prolactin growth hormone a1 prl prolactin PR:Q12884 MIO:01752 A prolyl endopeptidase FAP that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q12884] prolyl endopeptidase FAP 170 kDa melanoma membrane-bound gelatinase FAP FAPalpha SIMP dipeptidyl peptidase FAP fibroblast activation protein alpha gelatine degradation protease FAP hFAP integral membrane serine protease post-proline cleaving enzyme seprase serine integral membrane protease surface-expressed protease NCIT:C136721 MIO:01753 Pro-neuropeptide Y (97 aa, ~11 kDa) is encoded by the human NPY gene. This protein plays a role in the regulation of feeding behavior. [url:http://purl.obolibrary.org/obo/NCIT_C136721] pro-neuropeptide Y prepro-neuropeptide y pro-neuropeptide y NCIT:C114796 MIO:01754 Pro-opiomelanocortin (267 aa, ~29 kDa) is encoded by the human POMC gene. This protein plays a role in peptide hormone-dependent signaling. [url:http://purl.obolibrary.org/obo/NCIT_C114796] pro-opiomelanocortin corticotropin-lipotropin opiomelanocortin prepropeptide pomc pro-opiomelanocortin proopiomelanocortin proopiomelanocortin preproprotein NCIT:C122918 MIO:01755 Proprotein convertase subtilisin/kexin type 9 (692 aa, ~74 kDa) is encoded by the human PCSK9 gene. This protein is involved in the degradation of low density lipoprotein receptor family proteins. [url:http://purl.obolibrary.org/obo/NCIT_C122918] proprotein convertase subtilisin/kexin type 9 convertase subtilisin/kexin type 9 preproprotein narc-1 neural apoptosis regulated convertase 1 neural apoptosis-regulated convertase 1 pc9 pcsk9 proprotein convertase 9 proprotein convertase subtilisin/kexin type 9 subtilisin/kexin-like protease pc9 PR:P04090 MIO:01756 A prorelaxin H2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P04090] prorelaxin H2 RLN2 hRLN2 NCIT:C17525 MIO:01757 Prostate-specific antigen (261 aa, ~29 kDa) is encoded by the human KLK3 gene. This protein plays a role in both proteolysis and seminal fluid liquefaction. [url:http://purl.obolibrary.org/obo/NCIT_C17525] prostate-specific antigen antigen, prostate-specific ec 3.4.21.77 gamma-seminoprotein kallikrein-3 klk3 p-30 antigen prostate specific antigen prostate specific antigen preproprotein prostate-specific antigen prostate-specific antigen (psa) psa semenogelase seminin NCIT:C124856 MIO:01758 Protachykinin-1 (129 aa, ~15 kDa) is encoded by the human TAC1 gene. This protein is involved in neuronal excitation, behavioral responses, and smooth muscle contraction. [url:http://purl.obolibrary.org/obo/NCIT_C124856] protachykinin-1 ppt preprotachykinin protachykinin protachykinin 1 protachykinin-1 EFO:0004637 NCIT:C100436 PMID:33620437 MIO:01759 Protein S (also known as PROS) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by the PROS1 gene. [url:https://en.wikipedia.org/wiki/Protein_S] protein S PROTS NCIT:C99610 PR:P23297 MIO:01760 Protein S100-A1 (94 aa, ~11 kDa) is encoded by the human S100A1 gene. This protein plays a role in the binding of zinc and calcium. [url:http://purl.obolibrary.org/obo/NCIT_C99610] protein S100-A1 S-100 protein alpha chain S-100 protein subunit alpha S100 calcium-binding protein A1 S100 protein, alpha polypeptide S100A1 PR:Q7Z4H4 MIO:01761 A protein ADM2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q7Z4H4] protein ADM2 ADM2 AM2 hADM2 intermedin PR:Q7Z3U7 MIO:01762 A protein MON2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q7Z3U7] protein MON2 homolog KIAA1040 MON2 SF21 hMON2 protein SF21 NCIT:C175986 MIO:01763 Protein O-GlcNAcase (916 aa, ~103 kDa) is encoded by the human OGA gene. This protein plays a role in the hydrolysis of O-linkages between N-acetylglucosamine (GlcNAc) and serine or threonine protein residues. [url:http://purl.obolibrary.org/obo/NCIT_C175986] protein O-GlcNAcase beta-hexosaminidase beta-n-acetylglucosaminidase beta-n-acetylhexosaminidase bifunctional protein ncoat ec 3.2.1.169 meningioma-expressed antigen 5 mgea5 n-acetyl-beta-d-glucosaminidase n-acetyl-beta-glucosaminidase ncoat nuclear cytoplasmic o-glcnacase and acetyltransferase o-glcnacase o-linked n-acetylglucosaminidase oga protein o-glcnacase NCIT:C102439 MIO:01764 Protein S100-A4 (101 aa, ~12 kDa) is encoded by the human S100A4 gene. This protein is involved in both the positive regulation of signaling and calcium binding. [url:http://purl.obolibrary.org/obo/NCIT_C102439] protein S100-A4 calcium placental protein calvasculin fibroblast-specific protein-1 leukemia multidrug resistance associated protein malignant transformation suppression 1 metastasin placental calcium-binding protein protein mts1 protein s100-a4 s100 calcium-binding protein a4 NCIT:C29927 MIO:01765 Protein S100-A8 (93 aa, ~11 kDa) is encoded by the human S100A8 gene. This protein is involved in calcium and zinc binding and in the modulation of leukocyte functions. [url:http://purl.obolibrary.org/obo/NCIT_C29927] protein S100-A8 caga calgranulin a calprotectin l1l subunit cfag cgla cp-10 cystic fibrosis antigen leukocyte l1 complex light chain mif migration inhibitory factor-related protein 8 mrp8 myeloid-related protein 8 nif p8 protein s100-a8 s100 calcium binding protein a8 s100 calcium-binding protein a8 s100a8 urinary stone protein band a NCIT:C29928 MIO:01766 Protein S100-A9 (114 aa, ~13 kDa) is encoded by the human S100A9 gene. This protein plays a role in the regulation of leukocyte functions and binding to calcium and zinc. [url:http://purl.obolibrary.org/obo/NCIT_C29928] protein S100-A9 cagb calgranulin b calgranulin-b cfag cglb l1ag leukocyte l1 complex heavy chain mif migration inhibitory factor-related protein 14 mrp-14 mrp14 myeloid-related protein 14 nif p14 protein s100-a9 s100 calcium binding protein a9 s100 calcium-binding protein a9 s100a9 NCIT:C18560 MIO:01767 Proto-oncogene Wnt-1 (370 aa, ~41 kDa) is encoded by the human WNT1 gene. This protein plays a role in the stimulation of Wnt signaling pathways. [url:http://purl.obolibrary.org/obo/NCIT_C18560] proto-oncogene Wnt-1 proto-oncogene int-1 homolog proto-oncogene protein wnt-1 proto-oncogene wnt-1 wnt-1 wnt1 NCIT:C17522 PR:P16109 MIO:01768 P-Selectin is a cell surface adhesion molecule that mediates the interaction of activated endothelial cells or platelets with neutrophils and monocytes. The protein is detected in megakaryocytes and platelets, as well as in vascular endothelial cells, but not in other cell types. In endothelia, the protein is localized to the membranes of Weibel-Palade bodies, intracellular storage granules for von Willebrand factor. CD24 is a ligand for P-selectin. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and may function in the intracellular trafficking of P-selectin. [url:http://purl.obolibrary.org/obo/NCIT_C17522] P-selectin CD62 CD62 antigen-like family member P CD62P CD62P antigen GMP-140 GMP140 LECAM3 PADGEM SELP granule membrane protein 140 granulocyte membrane protein latelet activation dependent granule-external membrane protein leukocyte-endothelial cell adhesion molecule 3 platelet activation dependent granule-external membrane protein platelet alpha-granule membrane protein NCIT:C29873 MIO:01769 Receptor-interacting serine/threonine-protein kinase 3 (518 aa, ~57 kDa) is encoded by the human RIPK3 gene. This protein plays a role in the induction of necrosis. [url:http://purl.obolibrary.org/obo/NCIT_C29873] receptor-interacting serine/threonine-protein kinase 3 receptor-interacting protein 3 receptor-interacting serine/threonine protein kinase 3 receptor-interacting serine/threonine-protein kinase 3 rip-3 rip-like protein kinase 3 rip3 ripk3 MIO:01770 Relaxin is a protein hormone of about 6000 Da first described in 1926 by Frederick Hisaw. The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1 (RLN1), 2 (RLN2) and 3 (RLN3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, and INSL6 remain uncharacterised.[url:https://en.wikipedia.org/wiki/Relaxin] relaxin NCIT:C113591 MIO:01771 Renin (406 aa, ~45 kDa) is encoded by the human REN gene. This protein plays a role in activation of angiotensin. [url:http://purl.obolibrary.org/obo/NCIT_C113591] renin angiotensin-forming enzyme angiotensinogenase ec 3.4.23.15 ren renin renin precursor, renal NCIT:C113643 PR:Q9HD89 MIO:01772 Resistin (108 aa, ~11 kDa) is encoded by the human RETN gene. This protein plays a role in the regulation of insulin-mediated glucose metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C113643] resistin ADSF C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1 C/EBP-epsilon-rgulated myeloid-specific secreted cysteine-rich protein adipose tissue-specific secretory factor cysteine-rich secreted protein A12-alpha-Like 2 cysteine-rich secreted protein FIZZ3 PR:Q99969 MIO:01773 A retinoic acid receptor responder protein 2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q99969] retinoic acid receptor responder protein 2 RAR-responsive protein TIG2 RARRES2 TIG2 chemerin hRARRES2 tazarotene-induced gene 2 protein NCIT:C138098 MIO:01774 Retinol-binding protein 4 (201 aa, ~23 kDa) is encoded by the human RBP4 gene. This protein plays a role in retinol transport. [url:http://purl.obolibrary.org/obo/NCIT_C138098] retinol-binding protein 4 plasma retinol-binding protein prbp rbp4 retinol-binding protein 4 NCIT:C29877 MIO:01775 Rho-associated protein kinase 1 (1354 aa, ~158 kDa) is encoded by the human ROCK1 gene. This protein is involved in both the propagation of Rho signaling and protein phosphorylation. [url:http://purl.obolibrary.org/obo/NCIT_C29877] rho-associated protein kinase 1 p160 rock-1 p160-rock p160rock renal carcinoma antigen ny-ren-35 rho kinase rho-associated protein kinase 1 rho-associated, coiled-coil containing protein kinase 1 rho-associated, coiled-coil-containing protein kinase i rock-i rock1 NCIT:C104064 MIO:01776 Scavenger receptor cysteine-rich type 1 protein M130 (1156 aa, ~125 kDa) is encoded by the human CD163 gene. This protein plays a role in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages. [url:http://purl.obolibrary.org/obo/NCIT_C104064] scavenger receptor cysteine-rich type 1 protein M130 antigen cd163 cd163 cd163 antigen cd163 molecule hemoglobin scavenger receptor macrophage-associated antigen scavenger receptor cysteine-rich type 1 protein m130 NCIT:C105006 MIO:01777 Secreted frizzled-related protein 5 (317 aa, ~36 kDa) is encoded by the human SFRP5 gene. This protein may play a role in determining the polarity of photoreceptor cells in the retina. [url:http://purl.obolibrary.org/obo/NCIT_C105006] secreted frizzled-related protein 5 frizzled-related protein 1b frp-1b sarp-3 secreted apoptosis related protein 3 secreted apoptosis-related protein 3 secreted frizzled-related protein 5 sfrp-5 NCIT:C105739 MIO:01778 Selenoprotein P (381 aa, ~43 kDa) is encoded by the human SELENOP gene. This protein is involved in the modulation of selenium metabolism. [url:http://purl.obolibrary.org/obo/NCIT_C105739] selenoprotein P selenop selenoprotein p sep sepp1 PR:O43464 MIO:01779 A serine protease HTRA2, mitochondrial that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_O43464] serine protease HTRA2, mitochondrial HTRA2 OMI Omi stress-regulated endoprotease PRSS25 hHTRA2 high temperature requirement protein A2 serine protease 25 serine proteinase OMI PR:000014681 MIO:01780 A serpin that is a translation product of the human SERPINA12 gene or a 1:1 ortholog thereof. [url:http://purl.obolibrary.org/obo/PR_000014681] serpin A12 OL-64 SERPINA12 vaspin visceral adipose tissue-derived serine protease inhibitor visceral adipose-specific serpin NCIT:C178652 MIO:01781 Serum amyloid A-1 protein (122 aa, ~14 kDa) is encoded by the human SAA1 gene. This protein plays a role in heparin binding and acute phase inflammatory responses. [url:http://purl.obolibrary.org/obo/NCIT_C178652] serum amyloid A-1 protein SAA SAA1 amyloid fibril protein AA amyloid protein A precursor serum amyloid A serum amyloid A protein serum amyloid A1 tumor protein P53 inducible protein 4 NCIT:C116049 PR:P27169 MIO:01782 Serum paraoxonase/arylesterase 1 (355 aa, ~40 kDa) is encoded by the human PON1 gene. This protein plays a role in the catabolism of aromatic carboxylic acid esters, organophosphates and lactones. [url:http://purl.obolibrary.org/obo/NCIT_C116049] serum paraoxonase/arylesterase 1 A-esterase 1 EC 3.1.1.2 EC 3.1.1.81 EC 3.1.8.1 K-45 PON 1 PON1 aromatic esterase 1 arylesterase B-type esterase A paraoxonase B-type serum aryldiakylphosphatase serum aryldialkylphosphatase 1 NCIT:C61033 MIO:01783 A quantitative measurement of the total amount of protein present in a sample of serum. [url:http://purl.obolibrary.org/obo/NCIT_C61033] serum total protein total serum protein PR:Q8IWY4 MIO:01784 A signal peptide, CUB and EGF-like domain-containing protein 1 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q8IWY4] signal peptide, CUB and EGF-like domain-containing protein 1 SCUBE1 hSCUBE1 NCIT:C105876 MIO:01785 Sodium-dependent serotonin transporter (630 aa, ~70 kDa) is encoded by the human SLC6A4 gene. This protein is involved in serotonin internalization. [url:http://purl.obolibrary.org/obo/NCIT_C105876] sodium-dependent serotonin transporter 5-hydroxytryptamine transporter 5ht transporter 5htt na+/cl- dependent serotonin transporter slc6a4 sodium-dependent serotonin transporter solute carrier family 6 member 4 NCIT:C2288 MIO:01786 Somatotropin (217 aa, ~25 kDa) is encoded by the human GH1 gene. This protein is involved in the regulation of many physiologic processes, including the growth of organs and tissues and the metabolism of amino acids and proteins. [url:http://purl.obolibrary.org/obo/NCIT_C2288] somatotropin gh gh-n ghn growth hormone growth hormone 1 hghn pituitary growth hormone somatotropic hormone somatotropin NCIT:C159510 MIO:01787 Stabilin-1 (2570 aa, ~275 kDa) is encoded by the human STAB1 gene. This protein is involved in signal transduction mediated by acetylated low density lipoprotein binding. [url:http://purl.obolibrary.org/obo/NCIT_C159510] stabilin-1 clever-1 common lymphatic endothelial and vascular endothelial receptor-1 fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor 1 fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-1 fasciclin, egf-like, laminin-type egf-like and link domain-containing scavenger receptor 1 feel-1 ms-1 antigen stab-1 stab1 stabilin 1 stabilin-1 NCIT:C30004 MIO:01788 Stanniocalcin-1 (247 aa, ~28 kDa) is encoded by the human STC1 gene. This protein plays a role in renal phosphate reabsorption. [url:http://purl.obolibrary.org/obo/NCIT_C30004] stanniocalcin-1 stanniocalcin 1 stanniocalcin-1 stc-1 stc1 NCIT:C97975 MIO:01789 Suppressor of cytokine signaling 3 (225 aa, ~25 kDa) is encoded by the human SOCS3 gene. This protein is involved in the down-regulation of cytokine-stimulated signaling. [url:http://purl.obolibrary.org/obo/NCIT_C97975] suppressor of cytokine signaling 3 cis-3 cytokine-inducible sh2 protein 3 socs-3 ssi-3 stat-induced stat inhibitor 3 suppressor of cytokine signaling 3 NCIT:C96914 MIO:01790 Syndecan-1 (310 aa, ~32 kDa) is encoded by the human SDC1 gene. This protein is involved in the mediation of cell adhesion, signaling and cytoskeletal organization. [url:http://purl.obolibrary.org/obo/NCIT_C96914] syndecan-1 antigen cd138 cd138 cd138 antigen sdc1 synd1 syndecan-1 NCIT:C101433 MIO:01791 Syndecan-4 (198 aa, ~22 kDa) is encoded by the human SDC4 gene. This protein is involved in cell surface localization of heparan sulfate. [url:http://purl.obolibrary.org/obo/NCIT_C101433] syndecan-4 amphiglycan ryudocan ryudocan core protein synd4 syndecan-4 NCIT:C17338 MIO:01792 Tenascin (2201 aa, ~241 kDa) is encoded by the human TNC gene. This protein is involved in neuron migration and axon guidance. [url:http://purl.obolibrary.org/obo/NCIT_C17338] tenascin cytotactin glioma-associated-extracellular matrix antigen gmem gp 150-225 hexabrachion ji myotendinous antigen neuronectin tenascin tenascin c tenascin-c tn tn-c tnc PR:P05452 MIO:01793 A tetranectin that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P05452] tetranectin C-type lectin domain family 3 member B CLEC3B TN TNA hCLEC3B plasminogen kringle 4-binding protein NCIT:C30098 PR:000000047 MIO:01794 TGF-beta receptor type-1 (503 aa, ~56 kDa) is encoded by the human TGFBR1 gene. This protein plays a role in both TGF-beta-dependent signaling and serine/threonine phosphorylation. There are three TGF-beta receptors, Type I and Type II together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. Type III is a transmembrane proteoglycan with a large extracellular domain and a cytoplasmic domain that lacks an obvious signaling motif. [url:http://purl.obolibrary.org/obo/NCIT_C30098] TGF-beta receptor type-1 ALK-5 ALK5 ESK2 SKR4 TGF-beta receptor type I TGF-beta type I receptor TGFBR1 TGFR-1 TbetaR-I activin A receptor type II-like protein kinase of 53kD activin receptor-like kinase 5 serine/threonine-protein kinase receptor R4 transforming growth factor beta receptor 1 transforming growth factor beta receptor I transforming growth factor beta receptor type I transforming growth factor-beta receptor type I NCIT:C991 MIO:01795 Adult T-cell Leukemia derived factor: Human thioredoxin. A cytokine. [url:http://purl.obolibrary.org/obo/NCIT_C991] thioredoxin recombinant atl derived factor thioredoxin thioredoxin human NCIT:C161371 NCIT:C17272 PMID:33620437 MIO:01796 A protease involved in clotting. [url:http://purl.obolibrary.org/obo/NCIT_C17272] thrombin antithrombin complex TAT TAT complexes TATC Thrombin-Antithrombin Complex thrombin antithrombin complex antigen thrombin-antithrombin III complex thrombin–antithrombin EFO:0007774 NCIT:C101380 NCIT:C135444 PMID:33620437 PR:000002105 UMLS:C0373785 MIO:01797 Thrombomodulin (575 aa, ~60 kDa) is encoded by the human THBD gene. This protein plays a role in thrombin binding, fibrinolysis and coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C101380] thrombomodulin Antigen CD141 BDCA-3 CD141 CD141 Antigen Fetomodulin TM NCIT:C17547 MIO:01798 Thrombospondin-1 (1170 aa, ~129 kDa) is encoded by the human THBS1 gene. This protein plays a role in both cell-cell and cell-matrix interactions. [url:http://purl.obolibrary.org/obo/NCIT_C17547] thrombospondin-1 thbs1 thrombospondin 1 thrombospondin-1 tsp tsp-1 tsp1 PMID:8787726 MIO:01799 Thrombus precursor protein (TpP) is an important indicator of thrombin activity and evaluation of coagulation is normal.[PMID:8787726] thrombus precursor protein TpP NCIT:C137963 MIO:01800 Thymosin beta-4 (44 aa, ~5 kDa) is encoded by the human TMSB4X gene. This protein plays a role in the downregulation of actin polymerization. [url:http://purl.obolibrary.org/obo/NCIT_C137963] thymosin beta-4 fx prothymosin beta-4 t beta-4 thymosin beta-4 tmsb4x NCIT:C2280 MIO:01801 A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland. [url:http://purl.obolibrary.org/obo/NCIT_C2280] thyroid-stimulating hormone thyreotrophic hormone thyreotropin thyroid stimulating hormone thyroid-stimulating hormone thyrotropic hormone thyrotropin tsh NCIT:C17197 PMID:33620437 MIO:01802 Tissue factor (295 aa, ~33 kDa) is encoded by the human F3 gene. This protein is involved in both binding to coagulation factor VII and the initiation of blood coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C17197] tissue factor CD142 CD142 antigen F3 F3 protein TF coagulation factor III factor III thromboplastin tissue thromboplastin EFO:0007968 NCIT:C97262 PMID:33620437 MIO:01803 Tissue factor pathway inhibitor (304 aa, ~35 kDa) is encoded by the human TFPI gene. This protein plays a role in the inhibition of blood coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C97262] tissue factor pathway inhibitor EPI Extrinsic Pathway Inhibitor LACI Lipoprotein-Associated Coagulation Inhibitor TFPI SNOMED:103242005 MIO:01804 tissue plasminogen activator/plasminogen activator inhibitor-1 complex tPA-PAI complex tPA/PAI-1 complex tissue plasminogen activator-plasminogen activator inhibitor complex tissue plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) complex NCIT:C81993 SNOMED:121222004 UMLS:C2825874 MIO:01805 The determination of the amount of tissue plasminogen activator antigen present in a sample. [url:http://purl.obolibrary.org/obo/NCIT_C81993] tissue plasminogen activator antigen TPAAG tPA antigen tissue-type plasminogen activator antigen EFO:0004791 NCIT:C16995 PMID:33620437 MIO:01806 An enzyme made in the body that helps dissolve blood clots. A form of this enzyme is made in the laboratory to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. Tissue plasminogen activator is a type of systemic thrombolytic agent. [url:http://purl.obolibrary.org/obo/NCIT_C16995] tissue-type plasminogen activator EC 3.4.21.68 PLAT T-Plasminogen Activator t-PA tPA tissue plasminogen activator NCIT:C101758 MIO:01807 Titin (34350 aa, ~3816 kDa) is encoded by the human TTN gene. This protein plays a role in muscle filament structure and contraction. [url:http://purl.obolibrary.org/obo/NCIT_C101758] titin connectin rhabdomyosarcoma antigen mu-rms-40.14 titin ttn NCIT:C30101 MIO:01808 Toll-like receptor 1 (786 aa, ~90 kDa) is encoded by the human TLR1 gene. This protein plays a role in antimicrobial immune responses. [url:http://purl.obolibrary.org/obo/NCIT_C30101] toll-like receptor 1 cd281 antigen til tlr1 toll-like receptor 1 toll/interleukin-1 receptor-like toll/interleukin-1 receptor-like protein NCIT:C30102 MIO:01809 Toll-like receptor 2 (784 aa, ~90 kDa) is encoded by the human TLR2 gene. This protein is involved in signal transduction that modulates innate immunity. [url:http://purl.obolibrary.org/obo/NCIT_C30102] toll-like receptor 2 cd282 antigen til4 tlr2 toll-like receptor 2 toll/interleukin 1 receptor-like 4 toll/interleukin 1 receptor-like protein 4 NCIT:C30105 MIO:01810 Toll-like receptor 4 (839 aa, ~96 kDa) is encoded by the human TLR4 gene. This protein is involved in regulation of both fatty acid-induced inflammation and the innate immune response following bacterial lipopolysaccharide binding. [url:http://purl.obolibrary.org/obo/NCIT_C30105] toll-like receptor 4 Toll-like receptor 4 cd284 antigen htoll tlr4 toll toll homolog NCIT:C20457 MIO:01811 Transforming growth factor beta-1 (390 aa, ~44 kDa) is encoded by the human TGFB1 gene. This protein is involved in cell proliferation, cell death and a large number of signal transduction pathways. [url:http://purl.obolibrary.org/obo/NCIT_C20457] transforming growth factor beta-1 TGF-Beta 1 TGF-Beta-1 TGF-Beta1 TGFB1 Transforming Growth Factor Beta-1 Transforming Growth Factor-Beta 1 NCIT:C94620 MIO:01812 Transient receptor potential cation channel subfamily V member 6 (725 aa, ~83 kDa) is encoded by the human TRPV6 gene. This protein is involved in the mediation of calcium-dependent signaling that regulates both muscle contraction and neurotransmission. [url:http://purl.obolibrary.org/obo/NCIT_C94620] transient receptor potential cation channel subfamily V member 6 calcium transport protein 1 cat-l cat-like cat1 ecac2 epithelial calcium channel 2 transient receptor potential cation channel subfamily v member 6 transient receptor potential cation channel, subfamily v, member 6 trpv6 PR:Q86YW5 MIO:01813 A trem-like transcript 1 protein that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q86YW5] trem-like transcript 1 protein TLT-1 TLT1 TREML1 UNQ1825/PRO3438 hTREML1 triggering receptor expressed on myeloid cells-like protein 1 NCIT:C178292 MIO:01814 Triggering receptor expressed on myeloid cells 1 (234 aa, ~26 kDa) is encoded by the human TREM1 gene. This protein is involved in the stimulation of inflammation. [url:http://purl.obolibrary.org/obo/NCIT_C178292] triggering receptor expressed on myeloid cells 1 cd354 antigen trem-1 trem1 triggering receptor expressed on monocytes 1 triggering receptor expressed on myeloid cells 1 GO:0034385 MIO:01815 A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood. [url:http://purl.obolibrary.org/obo/GO_0034385] triglyceride-rich lipoprotein particle remnant-like particles-triglyceride PR:Q6ZMU5 MIO:01816 A tripartite motif-containing protein 72 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q6ZMU5] tripartite motif-containing protein 72 MG53 TRIM72 hTRIM72 mitsugumin-53 NCIT:C17800 PR:000001958 MIO:01817 Tumor necrosis factor receptor superfamily member 1A (455 aa, ~50 kDa) is encoded by the human TNFRSF1A gene. This protein is involved in tumor necrosis factor signaling and the initiation of apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C17800] tumor necrosis factor receptor superfamily member 1A CD120a antigen TNF-R1 TNF-RI TNFR-I TNFR1 TNFRSF1A p55 p60 sTNFR1 tumor necrosis factor binding protein 1 tumor necrosis factor receptor 1 tumor necrosis factor receptor type 1 tumor necrosis factor receptor type I tumor necrosis factor-alpha receptor NCIT:C18487 PR:000001959 MIO:01818 Tumor necrosis factor receptor superfamily member 1B (461 aa, ~48 kDa) is encoded by the human TNFRSF1B gene. This protein plays a role in tumor necrosis factor signaling and the negative regulation of apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C18487] tumor necrosis factor receptor superfamily member 1B CD120b CD120b antigen TNF-R-II TNF-R2 TNF-RII TNFR, 75-kD TNFR, 80-kD TNFR-II TNFR2 TNFRSF1B etanercept p75 p75 TNF receptor p80 TNF-alpha receptor tumor necrosis factor beta receptor tumor necrosis factor binding protein 2 tumor necrosis factor receptor 2 tumor necrosis factor receptor superfamily member 1B tumor necrosis factor receptor type II NCIT:C20533 MIO:01819 Tumor necrosis factor ligand superfamily member 10 (281 aa, ~33 kDa) is encoded by the human TNFSF10 gene. This protein plays a role in the induction of apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C20533] tumor necrosis factor ligand superfamily member 10 apo-2 ligand apo-2l apo2 ligand apo2l cd253 cd253 antigen chemokine tumor necrosis factor ligand superfamily member 10 protein trail tl2 tnf-related apoptosis inducing ligand tnf-related apoptosis inducing ligand trail tnf-related apoptosis-inducing ligand tnfsf10 tnfsf10 protein trail tumor necrosis factor ligand superfamily member 10 tumor necrosis factor ligand superfamily, member 10 tumor necrosis factor-related apoptosis-inducing ligand NCIT:C30113 MIO:01820 Tumor necrosis factor ligand superfamily member 11 (317 aa, ~35 kDa) is encoded by the human TNFSF11 gene. This protein is involved in osteoclast differentiation and activation and the regulation of the interactions between T-cells and dendritic cells. [url:http://purl.obolibrary.org/obo/NCIT_C30113] tumor necrosis factor ligand superfamily member 11 cd254 cd254 antigen odf opgl osteoclast differentiation factor osteoprotegerin ligand rankl receptor activator of nf-kappa-b ligand receptor activator of nuclear factor kappa b ligand receptor activator of nuclear factor kappa-b ligand tnf-related activation-induced cytokine tnfsf11 trance tumor necrosis factor ligand superfamily member 11 NCIT:C117068 MIO:01821 Tumor necrosis factor ligand superfamily member 12 (249 aa, ~27 kDa) is encoded by the human TNFSF12 gene. This protein plays a role in the positive regulation of angiogenesis. [url:http://purl.obolibrary.org/obo/NCIT_C117068] tumor necrosis factor ligand superfamily member 12 apo3 ligand apo3/dr3 ligand tnf superfamily member 12 tnf-related weak inducer of apoptosis tnfsf12 tumor necrosis factor ligand superfamily member 12 tweak NCIT:C94789 MIO:01822 Tumor necrosis factor ligand superfamily member 13B (285 aa, ~31 kDa) is encoded by the human TNFSF13B gene. This protein is involved in signal transduction and the modulation of B- and T-cell proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C94789] tumor necrosis factor ligand superfamily member 13B antigen cd257 b lymphocyte stimulator b-cell-activating factor b-lymphocyte stimulator baff blys cd257 cd257 antigen dendritic cell-derived tnf-like molecule tall-1 tnf homolog that activates apoptosis, nkfb, and jnk tnf- and apol-related leukocyte expressed ligand 1 tnfsf13b tumor necrosis factor ligand superfamily member 13b NCIT:C18178 MIO:01823 Tumor necrosis factor receptor superfamily member 10B (440 aa, ~48 kDa) is encoded by the human TNFRSF10B gene. This protein is involved in the modulation of the caspase cascade. [url:http://purl.obolibrary.org/obo/NCIT_C18178] tumor necrosis factor receptor superfamily member 10B apoptosis inducing protein trick2a/2b apoptosis inducing receptor trail-r2 cd262 antigen cytotoxic trail receptor-2 death domain containing receptor for trail/apo-2l death receptor 5 fas-like protein fas-like protein precursor p53-regulated dna damage-inducible cell death receptor (killer) tnf receptor superfamily member 10b tnf-related apoptosis-inducing ligand receptor 2 tnfrsf10b trail receptor 2 trail-r2 trailr-2 trailr2 tumor necrosis factor receptor superfamily member 10b tumor necrosis factor receptor-like protein ztnfr9 NCIT:C116206 NCIT:C30111 OMIT:0025294 MIO:01824 Tumor necrosis factor receptor superfamily member 11B (401 aa, ~46 kDa) is encoded by the human TNFRSF11B gene. This protein plays a role in the negative regulation of both osteoblast differentiation and bone resorption. [url:http://purl.obolibrary.org/obo/NCIT_C30111] tumor necrosis factor receptor superfamily member 11B OCIF OPG TNFRS11B osteoclastogenesis inhibitory factor osteoprotegerin tnfrsf11b tumor necrosis factor receptor superfamily member 11b NCIT:C17281 MIO:01825 Tumor necrosis factor receptor superfamily member 5 (277 aa, ~31 kDa) is encoded by the human CD40 gene. This protein is involved in the positive regulation of immunoglobulin secretion. [url:http://purl.obolibrary.org/obo/NCIT_C17281] tumor necrosis factor receptor superfamily member 5 b cell surface antigen cd40 b cell-associated molecule cd40 cd40 cd40 antigen cd40 type ii isoform cd40l receptor cdw40 nerve growth factor receptor-related b-lymphocyte activation molecule tnfrsf5 tumor necrosis factor receptor superfamily member 5 NCIT:C17776 MIO:01826 Tumor necrosis factor receptor superfamily member 6 (335 aa, ~38 kDa) is encoded by the human FAS gene. This protein is involved in the regulation of apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C17776] tumor necrosis factor receptor superfamily member 6 apo-1 antigen apo-1 cell surface antigen apoptosis antigen 1 apoptosis-mediating surface antigen fas cd95 antigen fas antigen faslg receptor surface antigen apo1 tnf receptor superfamily member 6 tnfrsf6 tumor necrosis factor receptor superfamily member 6 NCIT:C115147 MIO:01827 Any immunoglobulin that recognizes type V collagen. [url:http://purl.obolibrary.org/obo/NCIT_C115147] type V collagen antibody anti-collagen V antibody anti-collagen type V antibody anti-type V collagen antibody anti-type-V collagen antibody autoantibodies against native collagen type IV collagen V antibody collagen type V antibody type V collagen antibody type-V collagen antibody NCIT:C179874 MIO:01828 Type-1 angiotensin II receptor (359 aa, ~41 kDa) is encoded by the human AGTR1 gene. This protein is involved in modulation of blood pressure and blood volume. [url:http://purl.obolibrary.org/obo/NCIT_C179874] type-1 angiotensin II receptor agtr1 angiotensin ii receptor type 1 angiotensin ii type-1 receptor angiotensin receptor 1 at1 at1ar at1br type-1 angiotensin ii receptor NCIT:C17475 MIO:01829 Tyrosine-protein kinase receptor UFO (894 aa, ~98 kDa) is encoded by the human AXL gene. This protein plays a role in ligand binding, signaling and cellular growth and differentiation. [url:http://purl.obolibrary.org/obo/NCIT_C17475] tyrosine-protein kinase receptor UFO axl axl oncogene axl protein tyrosine-protein kinase receptor ufo PR:P55089 MIO:01830 A urocortin that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P55089] urocortin UCN hUCN EFO:0010932 NCIT:C17321 PMID:33620437 MIO:01831 Urokinase plasminogen activator surface receptor (335 aa, ~37 kDa) is encoded by the human PLAUR gene. This protein is involved in urokinase localization, plasmin formation, and signal transduction. [url:http://purl.obolibrary.org/obo/NCIT_C17321] urokinase plasminogen activator surface receptor CD87 CD87 Antigen Monocyte Activation Antigen Mo3 U-PAR U-Plasminogen Activator Receptor UPA Receptor Urokinase Plasminogen Activator Receptor Urokinase Receptor soluble uPA receptor suPAR uPAR urokinase-type plasminogen activator receptor NCIT:C17242 PMID:33620437 MIO:01832 Urokinase-type plasminogen activator (431 aa, ~49 kDa) is encoded by the human PLAU gene. This protein plays a role in both cell surface receptor binding and the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin. An enzyme that is made in the kidney and found in the urine. A form of this enzyme is made in the laboratory and used to dissolve blood clots or to prevent them from forming. [url:http://purl.obolibrary.org/obo/NCIT_C17242] urokinase-type plasminogen activator EC 3.4.21.73 PLAU Plasminogen Activator, Urinary U-Plasminogen Activator Urinary Plasminogen Activator Urokinase Plasminogen Activator plasminogen activator, urokinase u-PA uPA urokinase urokinase-plasminogen activator PR:O95399 MIO:01833 A urotensin-2 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_O95399] urotensin-2 U-II UII UNQ525/PRO1068 UTS2 hUTS2 urotensin II NCIT:C17975 PR:P17948 MIO:01834 Vascular endothelial growth factor receptor 1 (1338 aa, ~151 kDa) is encoded by the human FLT1 gene. This protein is involved in angiogenesis, tyrosine phosphorylation, ligand binding and signal transduction. [url:http://purl.obolibrary.org/obo/NCIT_C17975] vascular endothelial growth factor receptor 1 FLT FLT-1 FLT1 VEGFR VEGFR-1 VEGFR1 fms-like tyrosine kinase 1 receptor tyrosine kinase,class V sFLT-1 tyrosine protein kinase FRT tyrosine protein kinase receptor FLT tyrosine-protein kinase FRT tyrosine-protein kinase receptor FLT vascular endothelial growth factor receptor vascular permeability factor receptor NCIT:C48214 MIO:01835 Vascular cell adhesion protein 1 (739 aa, ~81 kDa) is encoded by the human VCAM1 gene. This protein is involved in the adhesion of immune cells. [url:http://purl.obolibrary.org/obo/NCIT_C48214] vascular cell adhesion protein 1 cd106 cd106 antigen incam-100 v-cam 1 vascular cell adhesion molecule 1 vascular cell adhesion molecule-1 vascular cell adhesion protein 1 vcam 1 NCIT:C105598 MIO:01836 Vascular endothelial growth factor B (207 aa, ~22 kDa) is encoded by the human VEGFB gene. This protein plays a role in both the formation of blood vessels and endothelial cell physiology. [url:http://purl.obolibrary.org/obo/NCIT_C105598] vascular endothelial growth factor B vascular endothelial growth factor b vegf-related factor PR:Q9NY84 MIO:01837 A vascular non-inflammatory molecule 3 that is encoded in the genome of human. [ PRO : DNx https://www.uniprot.org/uniprot/Q9NY84 ] vascular non-inflammatory molecule 3 VNN3 protein vanin-3 CHEBI:47776 SNOMED:259570006 MIO:01838 Triglycerides which are contained in very low density lipoproteins (VLDL). [url:http://purl.obolibrary.org/obo/CHEBI_47776] very low density lipoprotein triglyceride VLDL triglyceride very-low-density lipoprotein triglyceride PR:O14975 MIO:01839 A very long-chain acyl-CoA synthetase that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_O14975] very long-chain acyl-CoA synthetase ACSVL1 FACVL1 FATP-2 FATP2 SLC27A2 THCA-CoA ligase VLACS VLCS arachidonate--CoA ligase fatty acid transport protein 2 fatty-acid-coenzyme A ligase, very long-chain 1 hSLC27A2 long-chain-fatty-acid--CoA ligase phytanate--CoA ligase solute carrier family 27 member 2 very long-chain-fatty-acid-CoA ligase NCIT:C136790 MIO:01840 VIP peptides (170 aa, ~19 kDa) is encoded by the human VIP gene. This protein plays a role in the regulation of vasodilation. [url:http://purl.obolibrary.org/obo/NCIT_C136790] VIP peptides prepro-vip vip vip peptides NCIT:C102826 MIO:01841 Vitamin K-dependent protein C (461 aa, ~52 kDa) is encoded by the human PROC gene. This protein is involved in the degradation of factors Va and VIIIa. [url:http://purl.obolibrary.org/obo/NCIT_C102826] vitamin K-dependent protein C anticoagulant protein c autoprothrombin iia blood coagulation factor xiv ec 3.4.21.69 proc protein c vitamin k-dependent protein c NCIT:C107573 MIO:01842 Vitamin K-dependent protein S (676 aa, ~75 kDa) is encoded by the human PROS1 gene. This protein plays a role in coagulation regulation. [url:http://purl.obolibrary.org/obo/NCIT_C107573] vitamin K-dependent protein S protein sa vitamin k-dependent plasma protein s vitamin k-dependent protein s PR:P22891 MIO:01843 A vitamin K-dependent protein Z that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P22891] vitamin K-dependent protein Z PROZ hPROZ NCIT:C17283 MIO:01844 Vitronectin (478 aa, ~54 kDa) is encoded by the human VTN gene. This protein is involved in the modulation of cell-matrix adhesion and cell spreading. [url:http://purl.obolibrary.org/obo/NCIT_C17283] vitronectin complement s-protein epibolin s-protein serum spreading factor serum-spreading factor somatomedin b v75 vitronectin vtn EFO:0004629 NCIT:C16572 NCIT:C98799 PMID:33620437 UMLS:C2239219 MIO:01845 Is a quantification of von Willebrand factor (vWF) is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome.[1] Increased plasma levels in a large number of cardiovascular, neoplastic, and connective tissue diseases are presumed to arise from adverse changes to the endothelium, and may contribute to an increased risk of thrombosis. [url:http://www.ebi.ac.uk/efo/EFO_0004629] von Willebrand factor Coagulation Factor VIII VWF factor VIII related antigen factor VIII-von Willebrand factor vWFAg von Willebrand Factor Antigen SO:0000655 MIO:01846 An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product. [ http://www.sequenceontology.org/browser/current_svn/term/SO:ke ] ncRNA noncoding RNA BAO:0000274 MIO:01847 mRNA or messenger RNA is a genetic intermediate between DNA and protein. It is transcribed from DNA by RNA polymerases which is further processed by other enzymes. mRNA serves as the template to synthesize proteins on the ribosomes. [url:http://www.bioassayontology.org/baoBAO_0000274] mRNA messenger RNA MIO:01848 The ratio between the red blood cell distribution and erythrocyte count. red blood cell distribution width to erythrocyte count ratio MIO:01849 The ratio between the contrast volume and glomerular filtration rate. ratio of contrast volume to glomerular filtration rate NCIT:C64823 MIO:01850 The determination of the number of monocytes in a blood sample. [url:http://purl.obolibrary.org/obo/NCIT_C64823] monocyte count MONO monocyte monocytes NCIT:C51949 MIO:01851 The determination of the number of lymphocytes in a blood sample. [url:http://purl.obolibrary.org/obo/NCIT_C51949] lymphocyte count LYM lymphocyte lymphocytes MIO:01852 The ratio between the leukocyte count and mean platelet volume. leukocyte count to mean platelet volume ratio leukocyte count to MPV ratio NCIT:C51950 UMLS:C0200633 MIO:01853 A test to determine the number of neutrophils in a sample of blood. [url:http://purl.obolibrary.org/obo/NCIT_C51950] neutrophil count NEUT neutrophil NCIT:C64470 UMLS:C0200641 MIO:01854 The determination of the absolute number of basophils in a blood sample. [url:http://purl.obolibrary.org/obo/NCIT_C64470] total basophil count BASO basophil basophils MIO:01855 The ratio between the mean platelet volume and lymphocyt. mean platelet volume to lymphocyte ratio MPV to lymphocyte ratio MIO:01856 The ratio between the mean platelet volume and platelet count. mean platelet volume to platelet count ratio MPV to platelet count ratio NCIT:C128274 MIO:01857 DNA that is found in blood plasma and is not associated with cells in the circulation. [url:http://purl.obolibrary.org/obo/NCIT_C128274] circulating cell-free DNA cell free DNA cell free circulating DNA cfDNA circulating cell free DNA MIO:01858 The ratio between the red blood cell distribution and platelet. red blood cell distribution width to platelet ratio PMID:22291735 MIO:01859 Balloon ischaemic time included the whole time in which the treated artery was occluded by an inflated balloon catheter (balloon dilation or stent implantation). [url:https://pubmed.ncbi.nlm.nih.gov/22291735/] balloon ischemic time balloon ischaemic time MIO:01860 symptom-onset-to-balloon time EMS scene arrival to reperfusion S2B S2B time pain to balloon time pain-to-balloon time symptom onset-to-balloon time SNOMED:448906006 MIO:01861 time from onset of pain to administration of thrombolytic agent time from symptom onset to thrombolytic therapy MIO:01862 time from symptom-onset to operation to coronary artery bypass grafting CABG interval after symptom onset time interval from symptom onset to CABG time interval from symptom onset to coronary artery bypass grafting MIO:01863 time from symptom-onset to percutaneous coronary intervention interval between symptom-onset and percutaneous coronary intervention interval between the onset of symptoms and PCI pre-PCI time precoronary time symptom onset to PCI time symptom onset to primary PCI time time to pPCI MIO:01864 symptom onset between 0-12 hours MIO:01865 symptom onset between 06:00 pm-11:59 pm NCIT:C50750 MIO:01866 Traumatic damage of the spinal cord. [url:http://purl.obolibrary.org/obo/NCIT_C50750] spinal cord injury spinal cord injury PMID:33208092 MIO:01867 The presence of hypoxic liver injury (HLI) was defined as serum transaminase levels more than two times of the upper normal limit. [PMID:33208092] hypoxic liver injury HLI EFO:0005936 SYMP:0000475 UMLS:C0041667 MIO:01868 quantification of weight/height relationships below a certain threshold that classes an individual as underweight. This threshold may vary based on an individual's ethnicity but is commonly considered in European populations to correspond to a BMI < 18 [url:http://www.ebi.ac.uk/efo/EFO_0005936] underweight lean low body weight underweight body mass index status HP:0012175 MIO:01869 Poor anticoagulant response to activated protein C. A plasma is termed 'APC resistant' when the addition of exogenous APC fails to prolong its clotting time in an activated partial thromboplastin time assay. [url:http://purl.obolibrary.org/obo/HP_0012175] resistance to activated protein C ACP-R APCR activated protein C resistance HP:0012337 MIO:01870 An anomaly in the processes involved in the maintenance of an internal equilibrium. [ HPO : probinson ] [url:http://purl.obolibrary.org/obo/HP_0012337] abnormal homeostasis IDOMAL:0000532 MIO:01871 A circulatory collapse is defined as a general or specific failure of the circulation, either cardiac or peripheral in nature.[url:http://purl.obolibrary.org/obo/IDOMAL_0000532] circulatory collapse NCIT:C35016 MIO:01872 A life-threatening condition that requires immediate medical intervention. It is characterized by reduced blood flow that may result in damage of multiple organs. Types of shock include cardiogenic, hemorrhagic, septic, anaphylactic, and traumatic shock. [url:http://purl.obolibrary.org/obo/NCIT_C35016] shock EFO:0004517 MIO:01873 Arterial stiffness is a predictor of cardiovascular mortality. [url:http://www.ebi.ac.uk/efo/EFO_0004517] arterial stiffness NCIT:C100063 MIO:01874 Pathologic material in a vessel that obstructs myocardial perfusion. [url:http://purl.obolibrary.org/obo/NCIT_C100063] coronary vessel lesion NCIT:C168025 MIO:01875 An auscultated finding describing high or medium pitched and scratchy sound, generated by inflammation of the pericardial sac. (ACC/AHA) [url:http://purl.obolibrary.org/obo/NCIT_C168025] pericardial rub pericardial rub rub NCIT:C3408 MIO:01876 A laboratory test result indicating that there is an abnormally small number of platelets in the circulating blood. [url:http://purl.obolibrary.org/obo/NCIT_C3408] thrombocytopenia platelet count decreased thrombocytopenia thrombocytopenic disorder NCIT:C84479 MIO:01877 A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome. [url:http://purl.obolibrary.org/obo/NCIT_C84479] thrombophilia excessive blood clotting hypercoagulability hypercoagulability state hypercoagulable thrombophilia MIO:01878 circumflex artery narrowing narrowing of the circumflex artery narrowing MIO:01879 hematological failure PMID:31573723 MIO:01880 Inter-atrial dyssynchrony was defined as the difference between P-A' intervals at lateral mitral and tricuspid locations. [PMID:31573723] inter-atrial dyssynchrony PMID:12586252 MIO:01881 Intracoronary mobile mass was defined as a round form mass that was observed to be mobile and occupied the vessel lumen for several millimeters. [PMID:12586252] intracoronary mobile mass MIO:01882 long tubular lesion PMID:10496446 MIO:01883 Left ventricular regional wall motion abnormality (hypokinesia, akinesia, dyskinesia) in the region overlying the anterolateral or posteromedial papillary muscle was considered to be papillary muscle region asynergy. [PMID:10496446] papillary muscle region asynergy PMID:31707554 MIO:01884 PMI was scored based on the presence of late-enhancement in at least 2 consecutive short axis slices. [PMID:31707554] posteromedial papillary muscle infarction PMI MIO:01885 postsystolic thickening MIO:01886 saphenous vein graft-infarct-related artery PMID:31702950 MIO:01887 Calcified carotid artery atheromas (CCAAs), detected in panoramic radiographs, and periodontitis have both been associated with increased risk of cardiovascular disease.[PMID:31702950] calcified carotid artery atheroma CCAAs calcified carotid artery atheromas HP:0031313 MIO:01888 An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in abdominal aorta. [url:http://purl.obolibrary.org/obo/HP_0031313] abdominal aortic calcification AAC HP:0006670 MIO:01889 impaired myocardial contractility MP:0003037 MIO:01890 increased size of necrotic area of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors [url:http://purl.obolibrary.org/obo/MP_0003037] increased myocardial infarct size increased infarct size infarction expansion large infarct size larger IS MP:0004878 MIO:01891 increase in the normal force opposing blood flow in the peripheral blood vessels [url:http://purl.obolibrary.org/obo/MP_0004878] increased systemic vascular resistance high SVR increased SVR DICOM:122388 MIO:01892 Separation of neointimal hyperplasia from stent struts, usually seen only after treatment of in-stent restenosis. [url:http://dicom.nema.org/resources/ontology/DCM/122388] intra-stent dissection intrastent dissection PMID:26082844 MIO:01893 left atrial remodeling LA remodeling left atrial remodelling MIO:01894 In cardiology, ventricular dyssynchrony is a difference in the timing, or lack of synchrony, of contractions in different ventricles in the heart. Large differences in timing of contractions can reduce cardiac efficiency and is correlated with heart failure. [url:https://en.wikipedia.org/wiki/Ventricular_dyssynchronycite_note-Nagueh-1] left ventricular dyssynchrony LV dyssynchrony LV dyssynergy LV mechanical dyssynchron Ts-diff left ventricular dyssynergy left ventricular mechanical dyssynchrony left ventricular systolic dyssynchrony mechanical dyssynchron HP:0001712 MIO:01895 Enlargement or increased size of the heart left ventricle. [url:http://purl.obolibrary.org/obo/HP_0001712] left ventricular hypertrophy LVH heart left ventricle hypertrophy left ventricular wall hypertrophy NCIT:C172011 MIO:01896 Thickening of the myocardium often due to chronic pressure overload. [url:http://purl.obolibrary.org/obo/NCIT_C172011] myocardial hypertrophy HP:0001700 MIO:01897 Irreversible damage to heart tissue (myocardium) due to lack of oxygen after a heart attack (myocardial infarction). [url:http://purl.obolibrary.org/obo/HP_0001700] myocardial necrosis OMIT:0025730 MIO:01898 No reflow phenomenon is the failure of blood to reperfuse an ischemic area after the physical obstruction has been removed or bypassed. [url:https://en.wikipedia.org/wiki/No_reflow_phenomenon] no-reflow phenomenon no-reflow PMID:25770973 MIO:01899 Wraparound LAD was defined as an LAD reaching the apex and supplying the apical inferior aspect of the heart. [url:https://pubmed.ncbi.nlm.nih.gov/25770973/] wrap-around left anterior descending artery left anterior descending artery wrapping around the left ventricular apex wrap-around LAD wraparound LAD HP:0012667 MIO:01900 This feature can be appreciated using color kinesis, which tracks the motion of the endocardium in real time throughout systole and results in color-encoded images reflecting the magnitude and timing of endocardial motion.[url:http://purl.obolibrary.org/obo/HP_0012667] An abnormal motion of a segment of the left ventricle during the cardiac cycle. [url:http://purl.obolibrary.org/obo/HP_0012667] regional left ventricular wall motion abnormality abnormal regional myocardial motion regional abnormal wall motion regional wall motion abnormality EFO:0000405 MIO:01901 A disease or disorder that involves the digestive system. [url:http://www.ebi.ac.uk/efo/EFO_0000405] digestive system disease alimentary system disease digestive disease digestive system disease or disorder digestive system disorder disease of digestive system disease or disorder of digestive system disorder of digestive system git disease stomach or intestinal disorder NCIT:C141245 MIO:01902 The inability of the liver to perform its normal synthetic and metabolic functions. [url:http://purl.obolibrary.org/obo/NCIT_C141245] liver insufficiency hepatic failure hepatic insufficiency liver failure liver insufficiency HP:0003270 MIO:01903 Distention of the abdomen. [url:http://purl.obolibrary.org/obo/HP_0003270] abdominal distention abdominal bloating abdominal swelling belly bloating bloating distended abdomen HP:0001541 MIO:01904 Ascites is commonly associated with liver disease that has resulted in portal hypertension and low serum albumin levels.[url:http://purl.obolibrary.org/obo/HP_0001541] Accumulation of fluid in the peritoneal cavity. [url:http://purl.obolibrary.org/obo/HP_0001541] ascites accumulation of fluid in the abdomen HP:0500167 MIO:01905 An elevated amount of gastrin in the blood. [url:http://purl.obolibrary.org/obo/HP_0500167] hypergastrinemia elevated gastrin in the blood increased blood gastrin NCIT:C3507 SNOMED:414029004 MIO:01906 A disorder resulting from an abnormality in the immune system. [url:http://purl.obolibrary.org/obo/NCIT_C3507] immune system disorder disorder of immune function immune disorder immune disorders immune dysfunction unspecified immune system problem NCIT:C3137 MIO:01907 A finding of a localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. [url:http://purl.obolibrary.org/obo/NCIT_C3137] inflammation inflammatory EFO:0009903 MIO:01908 A disease involving a pathogenic inflammatory response in the anatomical structure. [url:http://www.ebi.ac.uk/efo/EFO_0009903] inflammatory disease anatomical structure inflammation inflammation of anatomical structure inflammatory disorder DOID:0060500 MIO:01909 An allergic disease that is triggered by a drug. [url:http://purl.obolibrary.org/obo/DOID_0060500] drug allergy NCIT:C21075 MIO:01910 The stimulus-response process involving the stimulation of peripheral pain-carrying nerve fibers (e.g., C-fibers, A-delta fibers) and the transmission of impulses along peripheral nerves of the central nervous system, where the stimulus is perceived as pain. (Taber's) [url:http://purl.obolibrary.org/obo/NCIT_C21075] nociception nociception NCIT:C34497 MIO:01911 Prolonged unconsciousness. A state of profound unconsciousness associated with markedly depressed cerebral activity. A condition in which a patient is in a state of deep sleep and cannot be awakened. A coma may be caused by many things, including trauma, drugs, toxins, or certain diseases. [url:http://purl.obolibrary.org/obo/NCIT_C34497] coma comatose HP:0500165 MIO:01912 An abnormality of the partial pressure of oxygen in the arterial blood. [ HPO : probinson ] [url:http://purl.obolibrary.org/obo/HP_0500165] abnormal blood oxygen level abnormal O2 blood concentration abnormal blood O2 level abnormal blood oxygen levels NCIT:C118318 MIO:01913 A clinical syndrome resulting from direct or indirect muscle injury and subsequent release of myoglobin into the plasma. [url:http://purl.obolibrary.org/obo/NCIT_C118318] rhabdomyolysis rhabdomyolysis NCIT:C26940 MIO:01914 Ongoing or recurrent pain that persists beyond that which is expected following acute injury, usually 3 months or more. [url:http://purl.obolibrary.org/obo/NCIT_C26940] chronic pain NCIT:C34887 MIO:01915 A sensation of discomfort secondary to surgery. [url:http://purl.obolibrary.org/obo/NCIT_C34887] post-operative pain post surgery pain post-operative pain postoperative pain HP:0100639 OMIT:0008300 MIO:01916 A multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological [url:http://purl.obolibrary.org/obo/HP_0100639] erectile dysfunction abnormal erection erectile abnormalities NCIT:C3046 MIO:01917 A traumatic injury to the bone in which the continuity of the bone is broken. [url:http://purl.obolibrary.org/obo/NCIT_C3046] fracture bone fracture fracture of bone MIO:01918 rotator cuff tear arthropathy NCIT:C53652 MIO:01919 Signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction. [url:http://purl.obolibrary.org/obo/NCIT_C53652] acute coronary syndrome ACS acute coronary ischemic syndromes acute coronary syndromes NCIT:C130995 MIO:01920 Reduced serum concentration of tri-iodothyronine caused by a variety of non-thyroidal conditions in which there is no dysfunction in the thyroid gland or the hypothalamic-pituitary axis. [url:http://purl.obolibrary.org/obo/NCIT_C130995] low T3 syndrome LT3S low triiodothyronine syndrome MONDO:0043726 MIO:01921 The development of potentially reversible physiologic derangement involving two or more organ systems not involved in the disorder that resulted in intensive care unit (ICU) admission, and arising in the wake of a potentially life-threatening physiologic insult. [url:http://purl.obolibrary.org/obo/MONDO_0043726] multiple organ dysfunction syndrome MODS NCIT:C27168 MIO:01922 A disorder characterized by recurrent episodic disruptions of breathing during sleep. It is caused by the intermittent relaxation of pharyngeal muscles leading to the narrowing or complete blockage of the upper airway. This results in compensatory arousal from sleep to breathe again. An anatomically narrow airway from body habitus or enlarged pharyngeal structures may also predispose to obstruction. Clinical presentation usually includes snoring, daytime sleepiness, difficulty concentrating and fatigue. Clinical course may progress to chronic hypoxemia with cardiovascular and cerebrovascular sequelae. [url:http://purl.obolibrary.org/obo/NCIT_C27168] obstructive sleep apnea syndrome obstructive sleep apnea-hypopnea syndrome OMIT:0009582 MIO:01923 Traditional Chinese medicine (TCM) is a branch of traditional medicine in China. It has been described as "fraught with pseudoscience", and the majority of its treatments as having no logical mechanism of action. [url:https://en.wikipedia.org/wiki/Traditional_Chinese_medicine] traditional Chinese medicine Chinese medicine medicine, Chinese traditional CHEBI:35842 MIO:01924 A drug used to treat rheumatoid arthritis. [url:http://purl.obolibrary.org/obo/CHEBI_35842] antirheumatic drug anti-rheumatic drugs antirheumatic agent antirheumatic drugs MIO:01925 A pharmacological agent that acts on neurotransmitter signaling pathways to alleviate the symptoms of depression. [url:http://purl.obolibrary.org/obo/NCIT_C265] antidepressant agent antidepressant antidepressant agents antidepressant drug antidepressant drugs antidepressants NCIT:C88516 MIO:01926 A group of sympathetic amines containing a catechol group derived from the amino acid tyrosine. Catecholamines are hormones and neuromodulators synthesized in the chromaffin cells of the adrenal glands and the postganglionic fibers of the sympathetic nervous system in response to stress. Examples of catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine, all of which participate in a wide variety of functions throughout the body. [url:http://purl.obolibrary.org/obo/NCIT_C88516] catecholamine catecholamines NCIT:C179456 MIO:01927 A hormonal contraceptive that utilizes a combination of estrogen and progestin (synthetic progesterone) to prevent ovulation and pregnancy. [url:http://purl.obolibrary.org/obo/NCIT_C179456] combination estrogen/progestin hormonal contraception combination estrogen/progestin hormonal contraception progestin and estrogen NCIT:C307 MIO:01928 Biotechnology-derived pharmaceutical agents made from living organisms or their products. Includes recombinant proteins, monoclonal antibodies, and nucleic acids. [url:http://purl.obolibrary.org/obo/NCIT_C307] biological agent biologic agent biological agent biological drug biological product biological products biologicals biologics biopharmaceuticals immunologic, immunochemical immunologics CHEBI:24261 MIO:01929 Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood.[url:http://purl.obolibrary.org/obo/CHEBI_24261] glucocorticoid glucocorticoids NCIT:C61523 MIO:01930 A nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS. [url:http://purl.obolibrary.org/obo/NCIT_C61523] abacavir 1592U89 2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)- ABC NCIT:C224 MIO:01931 A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies [url:http://purl.obolibrary.org/obo/NCIT_C224] allopurinol 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 1H-Pyrazolo[3,4-d]pyrimidin-4-ol 4'-HPP 4-Hydroxypyrazolo[3,4-d]pyrimidine allopurinol lopurin sigapurol zurinol NCIT:C62006 MIO:01932 A synthetic substance related to natural sympathomimetic amines. Amphetamine appears to exert its central nervous system (CNS) and peripheral effects indirectly by inducing the release of biogenic amines from their storage sites in nerve terminals. This agent is a commonly abused psychostimulant drug, which may be snorted, taken orally, smoked, or injected. Amphetamine induces psychologic dependence which is manifested by elevated mood, increased wakefulness, concentration, physical performance and a feeling of well-being. With sustained use, the effects of tachycardia and enhanced alertness diminish while psychotoxic effects such as hallucinations and delusions may occur. [url:http://purl.obolibrary.org/obo/NCIT_C62006] amphetamine amfetamine benzedrine desoxynorephedrine NCIT:C29710 MIO:01933 Also known as neuroleptics, major tranquilizers, or antischizophrenics, natural or synthetic. Antipsychotic Agents relieve and control the symptoms of schizophrenic illness (hallucinations, delusions, dementia). Most antipsychotic agents interfere with various neurotransmitter functions, often blocking dopamine receptors, and induce diverse behavioral, endocrine, motor-kinetic effects. A type of drug used to treat symptoms of psychosis. These include hallucinations (sights, sounds, smells, tastes, or touches that a person believes to be real but are not real), delusions (false beliefs), and dementia (loss of the ability to think, remember, learn, make decisions, and solve problems). Most antipsychotic agents block the action of certain chemicals in the nervous system. [url:http://purl.obolibrary.org/obo/NCIT_C29710] antipsychotic agent antipsychotic antipsychotic agents antipsychotic drug antipsychotic drugs major tranquilizer neuroleptic agent neuroleptic agents neuroleptic drug CHEBI:35474 MAXO:0000163 MIO:01934 Treatment with a drug that alleviates anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting the clarity of consciousness or neurologic conditions. [url:http://purl.obolibrary.org/obo/MAXO_0000163] anxiolytic drug anti-anxiety agents anti-anxiety drugs anxiolytic agents anxiolytics minor tranquilisers minor tranquilizers minor tranquilizing agents SNOMED:372907000 MIO:01935 Bisphosphonates are a class of drugs that prevent the loss of bone density, used to treat osteoporosis and similar diseases. They are the most commonly prescribed drugs used to treat osteoporosis. They are called bisphosphonates because they have two phosphonate (PO(OH) 2) groups. They are thus also called diphosphonates (bis- or di- + phosphonate). [url:https://en.wikipedia.org/wiki/Bisphosphonate] bisphosphonate bisphosphonates diphosphonate NCIT:C916 MIO:01936 A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme Q10 functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme Q10 may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. [url:http://purl.obolibrary.org/obo/NCIT_C916] coenzyme Q10 Co-Q10 CoQ10 Q10 Ubidecarenone Ubiquinone 10 ubiquinone vitamin Q10 NCIT:C431 MIO:01937 A nucleoside reverse transcriptase inhibitor analog of adenosine. [url:http://purl.obolibrary.org/obo/NCIT_C431] didanosine 2',3'-dideoxyinosine ddI didanosine didanosine EC dideoxyinosine videx videx EC NCIT:C80487 MIO:01938 A class of ester compounds of nitric acid (HNO3) and alcohols. [url:http://purl.obolibrary.org/obo/NCIT_C80487] nitrate nitrates NCIT:C1506 MIO:01939 A class of synthetic chemicals/drugs similar to opiates (opium derivatives) with analgesic properties. Due to binding to opiate receptors, opioids mimic opiate activity on neurons, various cells (i.e. lymphocytes), pain suppression and other neurobehavioral activity. [url:http://purl.obolibrary.org/obo/NCIT_C1506] opioid opioids NCIT:C389 MIO:01940 An agent taken orally to prevent conception. [url:http://purl.obolibrary.org/obo/NCIT_C389] oral contraceptive oral contraceptives NCIT:C783 MIO:01941 A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies of itself (for example, AIDS virus protease inhibitors), and some can prevent cancer cells from spreading. [url:http://purl.obolibrary.org/obo/NCIT_C783] protease inhibitor protease inhibitors NCIT:C29723 MIO:01942 Any one of the substituted benzimidazole compounds with anti-ulcer activity. A proton pump inhibitor is orally administered in the neutrally charged, inactive form and, upon entering the acidic environment of the parietal cell, gets protonated and converted into its active form. The active form will covalently and irreversibly bind to the proton pump, the H+/K+-ATPase, located on the surface of parietal cells. This leads to an inhibition of the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion. [url:http://purl.obolibrary.org/obo/NCIT_C29723] proton pump inhibitor PPI proton pump inhibitors CHEBI:145810 NCIT:C581 MIO:01943 A synthetic or animal-derived form of insulin used in the treatment of diabetes mellitus. Therapeutic insulin is formulated to be short-, intermediate- and long-acting in order to individualize an insulin regimen according to individual differences in glucose and insulin metabolism. Therapeutic insulin may be derived from porcine, bovine or recombinant sources. Endogenous human insulin, a pancreatic hormone composed of two polypeptide chains, is important for the normal metabolism of carbohydrates, proteins and fats and has anabolic effects on many types of tissues. [url:http://purl.obolibrary.org/obo/NCIT_C581] therapeutic insulin insulin insulin treatment recombinant insulin MIO:01944 A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response. TNF is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so TNF inhibitors may be used in their treatment. The important side effects of TNF inhibitors include lymphomas, infections (especially reactivation of latent tuberculosis), congestive heart failure, demyelinating disease, a lupus-like syndrome, induction of auto-antibodies, injection site reactions, and systemic side effects. [url:https://en.wikipedia.org/wiki/TNF_inhibitor] TNF inhibitor TNF inhibitors tumor necrosis factor (TNF) inhibitors tumor necrosis factor inhibitor tumor necrosis factor inhibitors MIO:01945 Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches. This drug class was first introduced in the 1990s. While effective at treating individual headaches, they do not provide preventive treatment and are not considered a cure. [url:https://en.wikipedia.org/wiki/Triptan] triptan triptans NCIT:C15192 MIO:01946 The infusion of whole blood or a blood component into the bloodstream. The infusion of components of blood or whole blood into the bloodstream. The blood may be donated from another person, or it may have been taken from the person earlier and stored until needed. Patient required an infusion of whole blood or a blood component directly into the bloodstream. [url:http://purl.obolibrary.org/obo/NCIT_C15192] blood transfusion blood component transfusion transfusion transfusion of blood products NCIT:C15221 MIO:01947 A procedure to remove toxic substances from the blood that is used in patients with end-stage chronic kidney disease or acute kidney failure. This includes hemodialysis and peritoneal dialysis. [url:http://purl.obolibrary.org/obo/NCIT_C15221] dialysis dialysis procedure dialysis therapy NCIT:C50822 MIO:01948 The measures applied for the restoration a person to life and/or consciousness. The act of resuscitation includes such components as artificial respiration and cardiac massage. [url:http://purl.obolibrary.org/obo/NCIT_C50822] resuscitation MIO:01949 systemic treatment MIO:01950 Epidural anaesthesia causes a loss of sensation, including pain, by blocking the transmission of signals through nerve fibres in or near the spinal cord. For this reason, epidurals are commonly used for pain control during childbirth and surgery. [url:https://en.wikipedia.org/wiki/Epidural_administration] epidurals ERO:0001108 MIO:01951 Agent delivery of a tube into an external or internal orifice of the body for the purpose of adding or removing fluids or air.[url:http://purl.obolibrary.org/obo/ERO_0001108] intubation MIO:01952 invasive therapy MIO:01953 lung impedance-guided pre-emptive therapy CIDO:0000367 MIO:01954 A respirator designed to protect the user from breathing in contaminants in the air, thus preserving the health of their respiratory tract.[url:http://purl.obolibrary.org/obo/CIDO_0000367] use of respirator NCIT:C15481 MIO:01955 A therapeutic regimen that utilizes pharmaceuticals to reduce serum levels of male sex hormones. [url:http://purl.obolibrary.org/obo/NCIT_C15481] antiandrogen therapy ADT androgen deprivation therapy androgen-deprivation therapy anti-androgen therapy anti-androgen treatment antiandrogen treatment hormone deprivation therapy hormone-deprivation therapy NCIT:C94631 MIO:01956 Treatment of retroviral infections with medications that target the virus directly, limiting the ability of infected cells to produce new virus particles. antiretroviral therapy ART anti-retroviral therapy SNOMED:281131004 MIO:01957 Therapeutic approaches that are limited, gradual, or well-established as opposed to radical methods. [url:http://purl.bioontology.org/ontology/MESH/D000072700] conservative therapy conservation therapy conservative management conservative strategy conservative treatment medical management NCIT:C64380 MIO:01958 A temporary loss of feeling and a complete loss of awareness that feels like a very deep sleep. It is caused by special drugs or other substances called anesthetics. General anesthesia keeps patients from feeling pain during surgery or other procedures. [url:http://purl.obolibrary.org/obo/NCIT_C64380] general anesthesia general anaesthesia general anesthesia procedure procedure related to general anesthesia PMID:30351514 MIO:01959 GDMT was defined according to American College of Cardiology/American Heart Association (ACC/AHA) class I recommendations, specifically, dual antiplatelet therapy, statin and beta-blocker for all AMI patients, and additional ACEI/ARB in patients with left ventricular ejection fraction (LVEF) less than 40%, hypertension, diabetes mellitus (DM) or chronic kidney disease (CKD). [url:https://pubmed.ncbi.nlm.nih.gov/30351514/] guideline-directed medical therapy GDMT guideline-based medication guideline-recommended medications NCIT:C15599 MIO:01960 Treatment with estrogens or estrogen/progesterone after menopause or ovariectomy to prevent pathological effects of decreased estrogen production. [url:http://purl.obolibrary.org/obo/NCIT_C15599] hormone replacement therapy HRT hormone replacement therapy type menopausal hormone therapy NCIT:C96408 MIO:01961 The administration of live or attenuated influenza virus for the prophylaxis of influenza. [url:http://purl.obolibrary.org/obo/NCIT_C96408] influenza vaccination NCIT:C175523 MIO:01962 The laterality intended for radiation therapy. [url:http://purl.obolibrary.org/obo/NCIT_C175523] radiation therapy laterality laterality of RT laterality of radiation therapy NCIT:C126400 MIO:01963 Treatments that substitute for the blood-filtering function of the kidneys. It includes dialysis (hemodialysis or peritoneal dialysis), hemofiltration, and hemodiafiltration. Kidney transplant may also be considered a renal replacement therapy. [url:http://purl.obolibrary.org/obo/NCIT_C126400] renal replacement therapy RRT NCIT:C157986 MIO:01964 Fusing two or more vertebrae into one. [url:http://purl.obolibrary.org/obo/NCIT_C157986] spinal fusion spinal fusion MIO:01965 length of surgery MIO:01966 abdominal aortic surgery MIO:01967 failure of coronary angioplasty MIO:01968 failure of percutaneous coronary intervention MIO:01969 failure of percutaneous transluminal coronary angioplasty MIO:01970 internal thoracic artery grafting MIO:01971 planned vascular operation MIO:01972 predilatation EFO:0009806 MIO:01973 A surgical procedure in which the hip joint is replaced by a prosthetic implant, that is, a hip prosthesis. A total hip replacement (total hip arthroplasty) consists of replacing both the acetabulum and the femoral head.[url:http://www.ebi.ac.uk/efo/EFO_0009806] total hip arthroplasty hip prosthesis implantation hip replacement hip replacement arthroplasty total hip replacement PMID:15615820 MIO:01974 Vein graft failure (VGF) is a condition in which vein grafts, which are used as alternative conduits in bypass surgeries (e.g. CABG), get occluded.[PMID:15615820] vein graft failure VGF SNOMED:73994005 MIO:01975 emergency operation SCDO:0000985 MIO:01976 The transference of a kidney from one human or animal to another. [url:http://purl.obolibrary.org/obo/SCDO_0000985] renal transplant kidney grafting kidney transplant kidney transplantation kidney transplantations renal transplantation renal transplantations ENVO:01000895 MIO:01977 A hydrological process in which irregular aggregates of snow fall to a planetary surface. [url:http://purl.obolibrary.org/obo/ENVO_01000895] snowfall snow fall NCIT:C94730 MIO:01978 The season between the winter solstice and the vernal equinox. [url:http://purl.obolibrary.org/obo/NCIT_C94730] winter XCO:0000306 XCO:0000307 MIO:01979 An activity or condition in which the air surrounding or encircling the organism has a relatively low, or lower than considered normal, temperature, i.e., air in which the molecules possess a lower than normal amount of random kinetic energy. [url:http://purl.obolibrary.org/obo/XCO_0000307] cold exposure cold ambient air exposure SBO:0000148 MIO:01980 Quantity resulting from the difference between two thermodynamic temperatures. A difference or interval of temperature may be expressed in Kelvins or in degrees Celsius. [url:http://biomodels.net/SBO/SBO_0000148] temperature difference ECTO:9000404 MIO:01981 exposure to nitrogen exposure to nitrogen molecular entity nitrogen oxide ECTO:7000001 MIO:01982 A exposure event involving the interaction of an exposure receptor to dust. [url:http://purl.obolibrary.org/obo/ECTO_7000001] exposure to dust dust exposure ECTO:9000034 MIO:01983 exposure to benzene benzene in ambient air ECTO:0000207 MIO:01984 exposure to carbon monoxide exposure to CO ECTO:9000052 MIO:01985 exposure to ozone exposure to O3 ENVO:01000405 MIO:01986 A portion of respirable suspended particulate matter is a form of particulate matter composed primarily of solid particles each with a diameter of 10 micrometers or less. exposure to PM10 PM(10) PM10 exposure to respirable suspended particulate matter respirable suspended particulate matter ENVO:01000415 MIO:01987 A portion of fine respirable suspended particulate matter is a form of particulate matter composed primarily of solid particles each with a diameter of 2.5 micrometers or less. [url:http://purl.obolibrary.org/obo/ENVO_01000415] exposure to PM2.5 PM2.5 exposure to fine respirable suspended particulate matter fine respirable suspended particulate matter ECTO:9000196 MIO:01988 exposure to sulfur dioxide exposure to SO2 PMID:19116496 MIO:01989 exposure to road traffic noise SNOMED:735932007 MIO:01990 occupational exposure to vibration vibration exposure working entailing vibrating machines EFO:0007585 NBO:0045004 MIO:01991 The consumption of the recreational drug cannabis (also known as marijuna and a number of other colloquial names). Cannabis use is illegal in some countries but not in others. cannabis consumption cannabis use cannabis use behaviour marijuana use NBO:0001915 MIO:01992 Behavior related to the intake of cocaine. [url:http://purl.obolibrary.org/obo/NBO_0001915] cocaine consumption cocaine use NBO:0002086 MIO:01993 Behavior related to the intake of nicotine. [url:http://purl.obolibrary.org/obo/NBO_0002086] nicotine consumption intake of nicotine nicotine intake ONS:0000094 MIO:01994 Dietary pattern represent the quantity, proportion, variety and combination of different foods and drinks consumed in meals, and the frequency with which they are habitually consumed. [url:http://purl.obolibrary.org/obo/ONS_0000094] dietary pattern dietary patterns SNOMED:226380009 MIO:01995 drink intake SNOMED:226379006 MIO:01996 food intake MAXO:0000106 NCIT:C1505 SNOMED:226320007 MIO:01997 The addition of one or more elements and/or chemical compounds that are either absent or deficient in an individual's daily diet. [url:http://purl.obolibrary.org/obo/MAXO_0000106] nutrient intake dietary supplement dietary supplements nutritional supplement nutritional supplementation supplement supplemental nutrition supplements PMID:23999993 MIO:01998 diet quality DOID:12797 SNOMED:74851005 MIO:01999 A substance abuse that involves the recurring use of hallucinogenic drugs despite negative consequences. [url:http://purl.obolibrary.org/obo/DOID_12797] hallucinogen abuse NCIT:C20701 UMLS:C0085762 MIO:02000 The use of alcoholic beverages to excess, either on individual occasions ("binge drinking") or as a regular practice. [url:http://purl.obolibrary.org/obo/NCIT_C20701] alcohol abuse alcohol use disorders ethanol abuse MONDO:0003969 MIO:02001 Disorders related or resulting from use of amphetamines. [url:http://purl.obolibrary.org/obo/MONDO_0003969] amphetamine abuse DOID:809 MIO:02002 A substance abuse that involves the recurring use of cocaine despite negative consequences. [url:http://purl.obolibrary.org/obo/DOID_809] cocaine abuse DOID:11206 MIO:02003 A substance abuse that involves the recurring use of opioid drugs despite negative consequences. [url:http://purl.obolibrary.org/obo/DOID_11206] opioid abuse opium addiction EFO:0002758 MAXO:0000766 ONS:1000042 SNOMED:16208003 MIO:02004 A recommendation to alter dietary intake where 30% or less of the calories come from fat. [url:http://purl.obolibrary.org/obo/MAXO_0000766] low-fat diet consumption of low-fat foods consumption of low-fat products intake of low-fat foods intake of low-fat products low fat diet intake low fat food consumption low fat food intake PMID:6023859 MIO:02005 The most cogent evidence so far is the epidemiological evidence that showed that the habitual intake of suger by men who developed myocardial infarction had been on the average twice as great as that of men of the same age wih no manifest arterial disease.[url:https://pubmed.ncbi.nlm.nih.gov/6023859/] reducing sugar intake reduce consumption of sugar reduce intake of sugar reduce sugar consumption reduce sugar intake reduced consumption of sugar reduced intake of sugar reduced sugar intake reducing consumption of sugar reducing intake of sugar reducing sugar consumption reducing the intake of sugar PMID:19161646 MIO:02006 The increasing fruit and vegetable intake was found to decrased MI risk.[url:https://pubmed.ncbi.nlm.nih.gov/19161646/] increasing fruit and vegetable intake increased consumption of fruit and vegetables increased consumption of fruits and vegetables increased consumption of vegetables and fruit increased fruit and vegetable consumption increased fruit and vegetable intake increased intake of fruit and vegetables increased vegetable and fruit intake increasing consumption of fruit and vegetables increasing consumption of vegetables and fruit increasing fruit and vegetable consumption increasing intake of fruit and vegetables increasing vegetable and fruit intake PMID:30563358 SNOMED:437391000124102 MIO:02007 Those who consume less sodium or more potassium have decreased risks of MI and stroke, due, at least in part, to direct effects on blood pressure.[url:https://pubmed.ncbi.nlm.nih.gov/30563358/] Increase in potassium content of diet compared to the assessed baseline intake of potassium for the individual. [url:http://snomed.info/id/437391000124102] increased potassium diet high potassium diet PMID:28185684 MIO:02008 The increasing fish intake was found to decrased MI risk.[url:https://pubmed.ncbi.nlm.nih.gov/28185684/] increasing fish intake increase consumption of fish increase fish intake increased consumption of fish increased fish consumption increased fish intake increased intake of fish increasing consumption of fish increasing fish consumption increasing intake of fish PMID:26888710 MIO:02009 Helnæs et al. showed that whole-grain intake was related to lower risk of myocardial infarction and suggest that the cereals rye and oats might especially hold a beneficial effect.[url:https://pubmed.ncbi.nlm.nih.gov/26888710/] increasing whole-grain intake increased consumption of wholegrain increased consumption of wholegrain foods increased intake of whole grain increased intake of wholegrain increased whole grain consumption increased whole-grain intake increased wholegrain consumption increasing consumption of wholegrain increasing the consumption of whole grain foods increasing the consumption of wholegrain increasing the dietary intake of whole grain foods increasing whole grain consumption increasing wholegrain consumption increasing wholegrain intake PMID:30563358 SNOMED:386619000 MIO:02010 Those who consume less sodium or more potassium have decreased risks of MI and stroke, due, at least in part, to direct effects on blood pressure.[url:https://pubmed.ncbi.nlm.nih.gov/30563358/] low sodium diet consume less sodium consumption of a low sodium diet diet in low sodium diets in low sodium low sodium consumption low sodium diets low sodium intake OMIT:0022848 ONS:1000005 MIO:02011 A moderate-fat, restricted-calorie, Mediterranean diet is rich in vegetables and low in red meat, with poultry and fish replacing beef and lamb. [url:http://purl.obolibrary.org/obo/ONS_1000038] Mediterranean diet diet, Mediterranean meditteranean diet dietary pattern NCIT:C39771 MIO:02012 20-60 minutes of exercise which elevates your heart rate to 35-60% of your maximum heart rate performed at least 3-4 times per week. Light exercises include housework, gardening, bowling, and slow walking. Maximum heart rate is approximately 220 minus current age in years. [url:http://purl.obolibrary.org/obo/NCIT_C39771] light exercise light activity mild exercise NCIT:C39772 MIO:02013 20-60 minutes of exercise which elevates your heart rate to 60-80% of your maximum heart rate performed at least 3-4 times per week. Moderate exercises include basketball, singles tennis, downhill skiing, and moderate walking. Maximum heart rate is approximately 220 minus current age in years. [url:http://purl.obolibrary.org/obo/NCIT_C39772] moderate exercise moderate activity SNOMED:225925001 MIO:02014 regular exercise NCIT:C39773 MIO:02015 20-60 minutes of exercise which elevates your heart rate to 80-90% of your maximum heart rate performed at least 3-4 times per week. Strenuous exercises include jogging, swimming, bicycling, and brisk walking. Maximum heart rate is approximately 220 minus current age in years. [url:http://purl.obolibrary.org/obo/NCIT_C39773] strenuous exercise strenuous activity vigorous exercise PMID:31150433 MIO:02016 light leisure time physical activity light LTPA low LTPA low level of LTPA low level of light leisure time physical activity low level of sports activities in leisure time PMID:31150433 MIO:02017 moderate leisure time physical activity moderate LTPA moderate level of sports activities in leisure time PMID:31150433 MIO:02018 Sedentary: Almost completely inactive or light activity less than 2 hours per week (e.g. reading, television and cinema). [url:https://pubmed.ncbi.nlm.nih.gov/31150433/] sedentary leisure time physical activity no sports activities in leisure time sedentary LTPA PMID:31150433 MIO:02019 strenuous leisure time physical activity high level of sports activities in leisure time strenuous LTPA MIO:02020 light occupational physical activity light OPA MIO:02021 moderate occupational physical activity moderate OPA MIO:02022 strenuous occupational physical activity strenuous OPA OMIT:0011788 MIO:02023 physical fitness MIO:02024 age under 65 years age 64 years or younger age </=64 years age <65 years age below 65 years age ≤64 years aged <65 years aged under 65 years under 65 years of age under 65 years old MIO:02025 age above 40 years above 40 years of age age 41 years or older age >/=41 years age >40 years age of more than 40 age over 40 years age ≥41 years aged >40 years aged over 40 aged over 40 years at least 41 years of age at least 41 years old over 40 years of age over 40 years old CMO:0002809 MIO:02026 A variability measurement in which the mean is calculated from the standard deviations or the standard deviation is calculated from the means of sequential one hour systolic blood pressure measurements. [url:http://purl.obolibrary.org/obo/CMO_0002809] systolic blood pressure variability SBP variability SBPV systolic BPV VSO:0000041 MIO:02027 The blood pressure in the pulmonary artery during the contraction of the left ventricle of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C120943] systolic pulmonary artery pressure PULSYSBP pulmonary artery systolic pressure pulmonary systolic pressure PMID:16643362 MIO:02028 The intra-QRS fragmentation score (FRA) of these magnetocardiographic QRS complexes was computed by calculating the number of extrema and their magnitudes within the QRS complex.[PMID:16643362] intra-QRS fragmentation score PMID:18233976 MIO:02029 It combines filtered QRS duration (fQRS), root mean-square voltage of the terminal QRS complex (RMS), and duration of low-amplitude signals (LAS) by simple logarithmic functions, which can be easily implemented in spreadsheet programs.[PMID:18233976] SAECG index PMID:1516189 MIO:02030 The score ranged from 0 to 4 depending on the number of pathological single spectral turbulence indices. Spectral turbulence score values greater than 2 were defined as abnormal.[PMID:1516189] spectral turbulence score ECG:000000836 PMID:4037949 MIO:02031 An ECG Score with a 32-point system for estimating the myocardial infarct size. The score is computed based upon 54 criteria across 10 of the leads in a 12 lead ECG, excluding leads III and aVR. See Selvester RH, et.al. (1985) Arch Intern Med. 145(10):1877-1881. [url:http://www.cvrgrid.org/files/ECGOntologyv1.owlECG_000000836] Selvester QRS score QRS score PMID:10085489 MIO:02032 The admission ECGs were classified into two patterns based on the J-point to R-wave amplitude ratio: pattern 1: those with J-point/R-wave ratio <0.5; pattern 2: patients with J-point/R-wave ratio >=0.5 in >=2 inferior leads (II, III and aVF). [PMID:10085489] J point to R wave amplitude ratio EFO:0005094 PMID:27924760 MIO:02033 normal value in adults is 60–110 ms (1.5–2.75 small boxes) < 120 ms or 0.12 s (three small boxes). Over the years, the P-wave duration progressively increases; normal maximal values of the P-wave duration with the advancement of age.[url:https://pubmed.ncbi.nlm.nih.gov/27924760/] measurement of the time from start to finish of the P wave, in the electrocardiograph illustrating the initial deflection of the cardiac cycle, representing the excitation of the atria. [url:http://www.ebi.ac.uk/efo/EFO_0005094] P wave duration P-wave duration EFO:0008379 MIO:02034 quantification of P wave terminal force, the product of the duration and the amplitude of the terminal negative part of the P-wave [url:http://www.ebi.ac.uk/efo/EFO_0008379] P wave terminal force PTF PMID:28205276 PMID:31608771 MIO:02035 Positive T wave in lead aVR (TaVR) on a routine 12-lead electrocardiogram, as a marker of repolarization abnormality, suggested to be a powerful, independent prognostic predictor of CV mortality in the general population and in some CV diseases.[url:https://pubmed.ncbi.nlm.nih.gov/31608771/] Positive T wave in lead aVR was defined as T‐wave amplitude >0 mV. [url:https://pubmed.ncbi.nlm.nih.gov/28205276/] positive T wave in lead aVR CMO:0000266 MIO:02036 The time from start to finish of the Q wave which illustrates the initial downward deflection related to the initial phase of depolarization of the ventricular myocardium and the depolarization of the interventricular septum as measured by an electrocardiograph [url:http://purl.obolibrary.org/obo/CMO_0000266] Q wave duration QW duration PMID:31869764 MIO:02037 Q wave area was calculated by using the equation of a triangle: duration*depth*0.5 (ms.mv). [url:https://pubmed.ncbi.nlm.nih.gov/31869764/] Q wave area QW area CMO:0000265 SNOMED:251224000 MIO:02038 The distance to the lowest part of the Q wave which shows the initial downward deflection related to the initial phase of depolarization of the ventricular myocardium and the depolarization of the interventricular septum as measured by electrocardiograph. [url:http://purl.obolibrary.org/obo/CMO_0000265] Q wave height Q wave depth QW depth SNOMED:251249001 MIO:02039 Q wave shape MIO:02040 The QRS loop in a two-dimensional plane was constructed by sampling the QRS complex of the first principal component as the x-coordinate and the corresponding data of the second principal component as the y-coordinate. [url:https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263894] QRS loop QRS vector loop PMID:21723240 MIO:02041 Intra-QRS high-frequency powers (IQHFP) within the QRS complex was assumed that abnormal IQHFP originates from the invisible arrhythmogenic potentials within the QRS complex.[PMID:21723240] intra-QRS high-frequency powers within the QRS complex PMID:24050376 MIO:02042 The scale of the WMI score was designed prospectively such that WMI-R > 0.5 was defined as positive WMI-R. [PMID:24050376] Wedensky Modulation Index for the QRS complex WMI-R EFO:0007742 MIO:02043 The magnitude of the portion of the electrocardiograph comprising the Q, R, and S waves which together represent ventricular depolarization. [url:http://www.ebi.ac.uk/efo/FEFO_0007742] QRS amplitude QRS vector EFO:0005055 MIO:02044 QRS duration is a measurement of the combined duration of the Q, R and S waves of the human heart's electric cycle [url:http://www.ebi.ac.uk/efo/EFO_0005055] QRS duration QRS interval PMID:28149660 MIO:02045 The QT dispersion was determined as the difference between the longest and shortest QT intervals in any derivation in the standard 12-lead ECG. [url:https://pubmed.ncbi.nlm.nih.gov/28149660/] QT dispersion QT interval dispersion QTd NCIT:C100391 PMID:23326164 MIO:02046 Extended QTc interval was defined as a duration of > 440 ms.[url:https://pubmed.ncbi.nlm.nih.gov/23326164/] The time interval between the start of the Q wave and the end of the T wave in the cardiac cycle as corrected with a Bazett’s formula. [url:http://purl.obolibrary.org/obo/NCIT_C100391] corrected QT interval QTCUNS QTc QTc Interval QTc duration corrected QT-interval heart rate-corrected QT interval EFO:0007741 MIO:02047 The magnitude of the R wave, which is the initial upward deflection of the QRS complex following the Q wave representing early depolarization of the ventricles as illustrated by an electrocardiograph. [url:http://www.ebi.ac.uk/efo/EFO_0007741] R wave amplitude R-wave amplitude EFO:0004831 MIO:02048 A RR interval is an electrocardiography measurement - R wave to R wave interval (RR interval) and is the inverse of the heart rate. [url:http://www.ebi.ac.uk/efo/EFO_0004831] RR interval R wave duration MIO:02049 R wave in lead V2 DICOM:122666 MIO:02050 Time relative to R-wave peak. [url:http://dicom.nema.org/resources/ontology/DCM/122666] R wave peak time R-wave peak time time relative to R-wave peak NCIT:C117799 MIO:02051 An aggregate ST segment deviation value based on the measurement of ST segment deviation from multiple beats within a single ECG. The method of aggregation, which can vary, is typically a measure of central tendency such as the mean. [url:http://purl.obolibrary.org/obo/NCIT_C117799] ST segment deviation ST segment shift ST-segment shift ST-segment shifts shift in ST segment PMID:15547654 MIO:02052 ST segment index was defined as the ratio of exercise-induced ST elevation amplitude in L II/L III.[PMID:15547654] ST segment index PMID:20106487 MIO:02053 ST segment vector magnitude (ST-VM), which constitutes the deflection of the ST segment from the isoelectric level, measured 60ms after the J-ponint; and ST segment change vector magnitude (STC-VM), which constitutes the spatial difference vector beteen the initial and the current ST-vector.[PMID:20106487] ST change-vector magnitude ST segment vector magnitude ST-VM PMID:30412109 MIO:02054 Complete ST resolution after reperfusion therapy was defined as 70% ST recovery. [url:https://pubmed.ncbi.nlm.nih.gov/30412109/] complete ST resolution 70% ST recovery ST recovery >/=70% complete ST-segment resolution PMID:30663468 MIO:02055 STR < 70% was defined as incomplete (ISTR). [url:https://pubmed.ncbi.nlm.nih.gov/30663468/] incomplete ST resolution ISTR ST recovery <70% ST resolution <70% failure of ST-segment resolution failure of STR failure to achieve complete STR incomplete ST-segment resolution incomplete STR incomplete-STR non-STR non-resolution PMID:16442395 MIO:02056 T wave loop EFO:0008334 MIO:02057 quantification of the duration of the T wave from its peak to its end [url:http://www.ebi.ac.uk/efo/EFO_0008334] T-peak to T-end interval T weave peak to T wave end T-wave peak to End (Tpe) time Tp-e interval TpTe TpTe interval Tpeak-end interval between the peak and the end of the T wave PMID:24050376 MIO:02058 The scale of the WMI score was designed prospectively such that WMI-T > 0.5 was defined as positive WMI-T. [PMID:24050376] Wedensky Modulation Index for the T wave WMI-T EFO:0008333 NCIT:C117814 MIO:02059 quantification of the magnitude of the T wave, the part of the electrocardiograph that represents the repolarisation or recovery of the ventricles [url:http://www.ebi.ac.uk/efo/EFO_0008333] T wave amplitude SNOMED:251254005 MIO:02060 U wave shape PMID:22950360 MIO:02061 heart rate turbulence index HRT index HRT parameters MIO:02062 heart rate variability index HRV index HRV indexs HRV methods HRV variable HRV variables heart rate variability indexes heart rate variability measurement heart rate variability method heart rate variability methods heart rate variability variable heart rate variability variables PMID:26262922 MIO:02063 The density HRV parameter density analysis (Dyx) is a new heart rate variability (HRV) measure based on multipole analysis of the Poincare plot obtained from RR interval time series, deriving information from both the time and frequency domain.[PMID:26262922] heart rate variability density PMID:23248218 MIO:02064 Heart rate acceleration capacity (AC) is determined by the overall trend analysis of the 24-hour heart rate.[PMID:23248218] heart rate acceleration capacity acceleration capacity of heart rate PMID:23248218 MIO:02065 Heart rate deceleration capacity (DC) is determined by the overall trend analysis of the 24-hour heart rate.[PMID:23248218] heart rate deceleration capacity DC deceleration capacity of heart rate deceleration capacity of rate MIO:02066 heart rate deceleration run MIO:02067 ventricular rate variability VRV NCIT:C2982 PMID:20031840 UMLS:C3277399 MIO:02068 A mental condition marked by ongoing feelings of sadness, despair, loss of energy, and difficulty dealing with normal daily life. Other symptoms of depression include feelings of worthlessness and hopelessness, loss of pleasure in activities, changes in eating or sleeping habits, and thoughts of death or suicide. Depression can affect anyone, and can be successfully treated. Depression affects 15-25% of cancer patients. [url:http://purl.obolibrary.org/obo/NCIT_C2982] depression depression disorder depressive disorder depressive disorders mental depression MFOEM:000029 MIO:02069 A negative emotion in response to a stressful elicitor. May be acute or chronic. Associated with health implications, such as impaired resistance to infectious diseases. [url:http://purl.obolibrary.org/obo/MFOEM_000029] stress stressed NCIT:C73506 MIO:02070 An emotional state characterized by marked annoyance or hostility. [url:http://purl.obolibrary.org/obo/NCIT_C73506] anger anger NCIT:C95503 MIO:02071 A feeling of worry and unhappiness. [url:http://purl.obolibrary.org/obo/NCIT_C95503] upset upset NCIT:C26696 MIO:02072 Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. [url:http://purl.obolibrary.org/obo/NCIT_C26696] anxiety NCIT:C95745 MIO:02073 A feeling of being unable to control yourself or your circumstances. [url:http://purl.obolibrary.org/obo/NCIT_C95745] helplessness helpless NCIT:C74531 MIO:02074 The despair you feel when you have abandoned hope of comfort or success. [url:http://purl.obolibrary.org/obo/NCIT_C74531] hopelessness hopeless SIO:000844 MIO:02075 Hostility is the intense negative emotion of being in conflict or opposition to someone or something. [url:http://semanticscience.org/resource/SIO_000844] hostility SIO:000852 MIO:02076 Loneliness is an unpleasant emotion in which a person feels a strong sense of emptiness, yearning distress and solitude resulting from inadequate quantity or quality of social relationships. [url:http://semanticscience.org/resource/SIO_000852] loneliness NCIT:C77962 MIO:02077 A feeling of optimism that one will attain a desired outcome. [url:http://purl.obolibrary.org/obo/NCIT_C77962] hope hopeful hopefulness NCIT:C94593 MIO:02078 The tendency to believe that there is good in everything and to have positive thoughts about most things that happen. [url:http://purl.obolibrary.org/obo/NCIT_C94593] optimism NCIT:C62188 MIO:02079 A state of refreshing tranquility; freedom from work, strain, or responsibility. [url:http://purl.obolibrary.org/obo/NCIT_C62188] relaxation relax relaxed SNOMED:266956001 MIO:02080 loss of job job loss job losses NCIT:C78237 SNOMED:105493001 MIO:02081 To stop working at one's occupation; the state of being retired. [url:http://purl.obolibrary.org/obo/NCIT_C78237] retirement retire retired retired, life event NCIT:C75563 MIO:02082 The state of not having a job. [url:http://purl.obolibrary.org/obo/NCIT_C75563] unemployed does not work doesn't work don't work not employed unemployment NCIT:C161419 MIO:02083 A person having origins in any of the original peoples of East Asian, including China, Japan, Korea, or Mongolia. [url:http://purl.obolibrary.org/obo/NCIT_C161419] East Asian East Asians NCIT:C41263 MIO:02084 Denotes a person whose ancestry is in the countries of the Indian sub-continent, including India, Pakistan, Bangladesh, and Sri Lanka. [url:http://purl.obolibrary.org/obo/NCIT_C41263] South Asian South Asians GSSO:001039 MIO:02085 An ethnic group of Americans with total or partial ancestry from any of the Black racial groups of Africa. The term typically refers to descendants of enslaved Black people who are from the United States. [url:http://purl.obolibrary.org/obo/GSSO_001039] African American African Americans African-American NCIT:C128938 MIO:02086 A person having origins in the original peoples of sub-Saharan Africa or the Caribbean. [url:http://purl.obolibrary.org/obo/NCIT_C128938] Black African race Negroid PMID:32757779 MIO:02087 Low education level was defined as none, elementary school or secondary school degree. [url:https://pubmed.ncbi.nlm.nih.gov/32757779/] low education level low education non-high school graduates NCIT:C76123 PMID:32757779 MIO:02088 High education level was defined as high school or university degree. [url:https://pubmed.ncbi.nlm.nih.gov/32757779/] high education level NCIT:C19250 MIO:02089 Refers to the costs required to deal with a specific situation (e.g., disease burden). [url:http://purl.obolibrary.org/obo/NCIT_C19250] economic burden NCIT:C70811 MIO:02090 A demographic parameter indicating the amount of earnings made by a family. [url:http://purl.obolibrary.org/obo/NCIT_C70811] household income MIO:02091 type of job NCIT:C92457 MIO:02092 The extent to which one can make decisions and exercise control over their work. [url:http://purl.obolibrary.org/obo/NCIT_C92457] job decision latitude decision latitude at work NCIT:C113717 PMID:22279115 UMLS:C3830315 MIO:02093 Irreparable damage to multiple organs/systems which is the result of chronic complications of diabetes. The affected organs/systems include the cardiovascular system, kidneys, eyes, nervous system, joints and feet. [url:http://purl.obolibrary.org/obo/NCIT_C113717] diabetes mellitus with end organ damage diabetes with end organ damage diabetes with end-organ damage end organ damage from diabetes NCIT:C168206 MIO:02094 A history of a first-degree relative that has had a myocardial infarction. [url:http://purl.obolibrary.org/obo/NCIT_C168206] family history of myocardial infarction family history of MI SNOMED:134439009 MIO:02095 family history of premature coronary artery disease family history of premature CAD family history: premature coronary heart disease DOID:13593 NCIT:C87167 MIO:02096 A potentially life-threatening pregnancy-related disorder characterized by tonic-clonic seizures in association with hypertension after the twentieth week of gestation and up to six weeks postpartum and in the absence of other potential causes of seizures. [url:http://purl.obolibrary.org/obo/NCIT_C87167] eclampsia PMID:11524051 MIO:02097 An excess of body weight, normally defined as an individual with a body mass index greater than 35 or a body weight greater than one hundred percent of ideal body weight. [url:http://purl.obolibrary.org/obo/NCIT_C34858] morbid obesity BMI > or =35 BMI ≥ 35 body mass index equal to or greater than 35 class II to III obesity excess adiposity HP:0012743 MIO:02098 Excessive fat around the stomach and abdomen. [url:http://purl.obolibrary.org/obo/HP_0012743] abdominal obesity central obesity HP:0025499 MIO:02099 Obesity with a body mass index of 30 to 34.9 kg per square meter. [url:http://purl.obolibrary.org/obo/HP_0025499] class I obesity BMI 30 to 34.9 BMI 30.0-34.9 body mass index 30.00 to 34.99 obese class I obesity grade 1 MIO:02100 age 60 years or older age >/=60 years age >59 years age above 59 years age over 59 years age ≥60 years aged >59 years aged over 59 years at least 60 years of age at least 60 years old over 59 years of age over 59 years old OAE:0000493 MIO:02101 an AE that occurs in cardiovascular system. [url:http://purl.obolibrary.org/obo/OAE_0000493] cardiovascular adverse events adverse cardiac events adverse cardiovascular events adverse cardiovascular outcomes cardiac combined events cardiac events cardiac outcome cardiac outcomes cardiovascular AE cardiovascular composite end point cardiovascular disease prognosis cardiovascular disorder AE cardiovascular events cardiovascular outcomes combined cardiovascular end-points coronary events coronary incidence NCIT:C28554 MIO:02102 The cessation of life. [url:http://purl.obolibrary.org/obo/NCIT_C28554] death dead deceased died expired mortality patient deceased OMIT:0011353 MIO:02103 A hospital readmission is an episode when a patient who had been discharged from a hospital is admitted again within a specified time interval. Readmission rates have increasingly been used as an outcome measure in health services research and as a quality benchmark for health systems. Generally, higher readmission rate indicates ineffectiveness of treatment during past hospitalizations. [url:https://en.wikipedia.org/wiki/Hospital_readmission] hospital readmission hospital readmissions patient readmission re-hospitalisation re-hospitalization readmission rehospitalization MIO:02104 Any noxious and unintended response associated with the use of a drug in humans. NOTE: 1. Post-approval: an adverse event that occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of diseases or for modification of physiological function. 2. Pre-approval: an adverse event that occurs at any dose and where a causal relationship is at least a reasonable possibility. 3. FDA 21 CFR 310.305 defines an adverse drug experience to include any adverse event, "whether or not considered to be drug-related." CDISC recognizes that current usage incorporates the concept of causality. [WHO Technical Report 498(1972); ICH E2A] [url:http://purl.obolibrary.org/obo/NCIT_C142385] adverse drug reaction ADR ADRs adverse drug experience adverse drug reactions SNOMED:305340004 MIO:02105 prolonged hospital stay admission to long stay hospital prolonged hospital length of stay prolonged hospitalization MIO:02106 improvement of left ventricular ejection fraction LVEF evolution LVEF improvement LVEF improvers improve LVEF improvement in LVEF improvement in ejection fraction normal LVEF normal left ventricular ejection fraction PMID:29523183 MIO:02107 Left ventricular reverse remodeling (LVRR) is a dynamic process of myocardial repair and usually takes a few months. LVRR is often accompanied with left ventricular volume decrease and left ventricular ejection fraction (LVEF) improvement. [url:https://pubmed.ncbi.nlm.nih.gov/29523183/] left ventricular reverse remodeling LVRR PMID:22477594 MIO:02108 The occurrence of myocardial contractile recovery was defined by improvement of regional wall motion score by at least one grade in at least two contiguous nonoverlap segments, along with at least 20% reduction in the global WMSI compared with baseline evaluation. [url:https://pubmed.ncbi.nlm.nih.gov/22477594/] myocardial contractile recovery contractile recovery improvement in contractile function preserved SWT preserved contractile function preserved systolic thickening recovery of contraction recovery of regional contractile function NCIT:C96340 MIO:02109 The length of time after treatment during which a patient survives with no sign of a particular complication of disease. [url:http://purl.obolibrary.org/obo/NCIT_C96340] event-free survival EFS NCIT:C76248 MIO:02110 A blood group indicating the presence on erythrocytes of both the A and B forms of the H Antigen. [url:http://purl.obolibrary.org/obo/NCIT_C76248] blood group AB blood type AB NCIT:C76247 MIO:02111 A blood group indicating the presence on erythrocytes of only the B form of the H Antigen. [url:http://purl.obolibrary.org/obo/NCIT_C76247] blood group B B blood type blood type B NCIT:C21007 MIO:02112 Any physical or mental impairment that interferes with an individual's ability to perform desired activities. [url:http://purl.obolibrary.org/obo/NCIT_C21007] disability handicap infirmity SCDO:0000746 MIO:02113 Emotional, psychological, and social well-being of an individual or group. [url:http://purl.obolibrary.org/obo/SCDO_0000746] mental health emotional health mental HRQoL mental health status mental health-related quality of life mental hygiene SCDO:0000900 MIO:02114 One's ability to carry out activities that require physical actions, ranging from self-care (activities of daily living) to more complex activities that require a combination of skills, often within a social context. Physical function is inclusive of the term disability and includes the full spectrum of physical functioning from severe impairment to exceptional physical abilities. [url:http://purl.obolibrary.org/obo/SCDO_0000900] physical health mobility motor function physical function physical health-related quality of life CHEBI:35457 NCIT:C247 UMLS:C0003015 MIO:02115 A pharmaceutical agent that inhibits angiotensin-converting enzyme (ACE), which catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis. It is primarily used for the reduction of proteinuria and the treatment of hypertension.; A drug that is used to lower blood pressure. An ACE inhibitor is a type of antihypertensive agent. [url:http://purl.obolibrary.org/obo/NCIT_C247] ACE inhibitor ACE-I ACE-inhibitor ACE-inhibitors ACEIs angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors angiotensin-converting-enzyme inhibition NCIT:C66930 UMLS:C0521942 MIO:02116 A class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. Although this class of agents is also used in diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure, it is primarily used for the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy. [url:http://purl.obolibrary.org/obo/NCIT_C66930] angiotensin II receptor antagonist ARB ARBs RAS blockers Renin-angiotensin system blockers angiotensin II receptor antagonists angiotensin II receptor blocker angiotensin II receptor blockers angiotensin receptor blocker angiotensin receptor blockers renin-angiotensin system blocker rennin-angiotensin system (RAS) blockers CHEBI:38215 NCIT:C333 UMLS:C0006684 MIO:02117 A pharmaceutical agent that inhibits the movement of calcium across through calcium channels in the cell membrane, preventing or decreasing the amount of calcium able to enter the cell. These drugs are used for their chronotropic, antihypertensive and vasodilatory effects. [url:http://purl.obolibrary.org/obo/NCIT_C333] calcium channel blocker CCB calcium channel blockers CHEBI:31547 NCIT:C47513 UMLS:C0961485 MIO:02118 A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure. [url:http://purl.obolibrary.org/obo/NCIT_C47513] eplerenone 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester inspra NCIT:C152281 MIO:02119 A neprilysn (NEP) inhibitor prodrug with natriuretic activity. Upon administration, sacubitril is metabolized by esterases to its active metabolite, sacubitrilat, which inhibits NEP, a neutral endopeptidase that cleaves natriuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP), as well as certain vasoconstricting peptides including as angiotensin I and II, and endothelin-1. Additionally, sacubitrilat may inhibit NEP-mediated catabolism of certain peptide-based agents, thereby improving their in vivo stability and increasing tumor cell exposure. [url:http://purl.obolibrary.org/obo/NCIT_C152281] sacubitril (2R,4S)-5-(biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid ethyl ester AHU 377 AHU-377 AHU377 NCIT:C47746 MIO:02120 A benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure. [url:http://purl.obolibrary.org/obo/NCIT_C47746] telmisartan (1,1'-Biphenyl)-2-carboxylic Acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)- 4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic Acid BIBR 277 micardis MIO:02121 The combination therapy of statin and acetylcysteine. statin plus acetylcysteine CHEBI:39548 NCIT:C61527 UMLS:C0286651 MIO:02122 A synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Atorvastatin also increases the number of LDL receptors on hepatic cell surfaces to enhance uptake and catabolism of LDL and reduces LDL production and the number of LDL particles. This agent lowers plasma cholesterol and lipoprotein levels and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. [url:http://purl.obolibrary.org/obo/NCIT_C61527] atorvastatin (betaR,deltaR)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid (betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-pyrrole-1-heptanoic Acid CHEBI:38561 CHEBI:5136 NCIT:C61768 UMLS:C0082608 MIO:02123 A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. [url:http://purl.obolibrary.org/obo/NCIT_C61768] fluvastatin CHEBI:40303 NCIT:C620 UMLS:C0024027 MIO:02124 A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation. [url:http://purl.obolibrary.org/obo/NCIT_C620] lovastatin (2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester lovastatin sodium mevacor mevinolin monacolin K NCIT:C87751 MIO:02125 A novel statin that induces plaque regression and elevates HDL-cholesterol levels. [url:http://purl.obolibrary.org/obo/NCIT_C87751] pitavastatin (3r,5s,6e)-7-[2-cyclopropyl-4-(p-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoic acid itavastatin pitavastatin CHEBI:63618 NCIT:C62070 UMLS:C0085542 MIO:02126 A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. [url:http://purl.obolibrary.org/obo/NCIT_C62070] pravastatin [1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid NCIT:C66523 MIO:02127 A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades. [url:http://purl.obolibrary.org/obo/NCIT_C66523] rosuvastatin rosuvastatin CHEBI:9150 NCIT:C29454 UMLS:C0074554 MIO:02128 A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. [url:http://purl.obolibrary.org/obo/NCIT_C29454] simvastatin MK 733 Zocor [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate synvinolin MIO:02129 The combination therapy of clopidogrel and aspirin. aspirin plus clopidogrel CHEBI:4653 NCIT:C445 UMLS:C0012582 MIO:02130 A synthetic agent derivative of pyrimido-pyrimidine, with antiplatelet properties. Dipyridamole inhibits adenosine uptake by platelets and endothelial cells, triggering an accumulation of cyclic adenosine monophosphate (cAMP), and inhibiting the stimulation of platelet aggregation by agents such as platelet activating factor and collagen. [url:http://purl.obolibrary.org/obo/NCIT_C445] dipyridamole 2,2',2'',2''''-[(4,8-Dipiperidinopyrimido-[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol DP persantine NCIT:C62076 MIO:02131 An agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities. In addition to its selective affinity for peroxisome proliferator-activated receptor (PPAR) gamma and its ability to lower blood glucose levels, rosiglitazone also exerts anti-inflammatory activity through its ability to inhibit nuclear factor-kappaB (NF-KB) activity and increase I-kappaB levels. In addition, rosiglitazone may cause fluid retention and may worsen congestive heart failure. This agent is also associated with an increased risk of heart attacks. [url:http://purl.obolibrary.org/obo/NCIT_C62076] rosiglitazone NCIT:C97936 MIO:02132 Sulfonamide urea derivatives with antihyperglycemic activity. Sulphonylurea antidiabetic agents bind to sulfonylurea receptor type 1 (SUR1), the subunit of ATP-sensitive inwardly-rectifier potassium (IKATP) channels on the membranes of pancreatic beta cells, thereby blocking the inward current flow (influx) of positively charged K+ ions into the cell. This results in tonic membrane depolarization, and induces a calcium ion influx through voltage-sensitive calcium channels; increased intracellular calcium ion levels trigger exocytosis of insulin-containing granules. This eventually induces secretion of insulin. The IKATP channels found in pancreatic islets are complexes of four IKATP 6.2 and four SUR1 subunits. In addition, some sulfonylureas of larger molecular size may increase the sensitivity of peripheral tissues to insulin mediated through peroxisome proliferator-activated receptor gamma (PPARgamma). [url:http://purl.obolibrary.org/obo/NCIT_C97936] sulfonylurea antidiabetic agent sulfonylurea MIO:02133 primary coronary angioplasty direct angioplasty direct coronary angioplasty emergency angioplasty emergency coronary angioplasty primary angioplasty EFO:0003951 NCIT:C38078 MIO:02134 A procedure to open an occluded coronary artery, performed by percutaneous introduction of a catheter into a peripheral (usually femoral) artery which is directed in a retrograde fashion to reach the diseased coronary artery. [url:http://purl.obolibrary.org/obo/NCIT_C38078] percutaneous transluminal coronary angioplasty PTCA PTCR balloon PTCA balloon angioplasty of coronary artery coronary balloon angioplasty percutaneous angioplasty of coronary artery percutaneous balloon angioplasty percutaneous transluminal coronary balloon angioplasty transcutaneous coronary angioplasty SNOMED:437857009 MIO:02135 everolimus-eluting stent everolimus 100 microgram/cc drug eluting stent SNOMED:411193005 MIO:02136 paclitaxel-eluting stent paclitaxel 1mcg/mm drug eluting stent paclitaxel-eluting stents SNOMED:411192000 MIO:02137 sirolimus-eluting stent sirolimus 140mcg/cc drug eluting stent sirolimus-eluting stents SNOMED:89814007 MIO:02138 repair of ventricular septal defect with prosthesis VSD repair VSR surgical repair correction of ventricular septal defect repair of heart septum with prosthesis ventricular septal defect repair ventricular septal rupture surgical repair MIO:02139 cardiopulmonary bypass operation time NCIT:C80449 MIO:02140 Surgery performed for the purpose of repairing stenosis or regurgitation of the mitral valve. [url:http://purl.obolibrary.org/obo/NCIT_C80449] mitral valve repair NCIT:C50825 MIO:02141 Surgery performed with the purpose of replacing a degenerated, calcified, malformed, dysfunctional, etc. mitral valve with bioprosthetic, homograft or autograft valve. [url:http://purl.obolibrary.org/obo/NCIT_C50825] mitral valve replacement NCIT:C158020 SNOMED:275227003 MIO:02142 The use of a laser to create channels directly into the heart muscle to encourage vascularization and treat severe coronary artery disease in those individuals who are not considered good candidates for standard bypass surgery. [url:http://purl.obolibrary.org/obo/NCIT_C158020] myocardial revascularization myocardial revascularization procedure transmyocardial revascularization MIO:02143 non-target lesion revascularization nontarget lesion revascularization MIO:02144 non-target vessel revascularization nontarget vessel revascularization PMID:20843572 MIO:02145 Target lesion revascularization was defined as PCI for restenosis or other complications of lesion that was treated segment from 5 mm proximal and 5 mm distal to stent. [url:https://pubmed.ncbi.nlm.nih.gov/20843572/] target lesion revascularization TLR TLRs PMID:20843572 MIO:02146 Target vessel revascularization was defined as repeated PCI for any segment of entire coronary artery proximal and distal to target lesion except for target lesion revascularization. [url:https://pubmed.ncbi.nlm.nih.gov/20843572/] target vessel revascularization TVR target-vessel revascularization NCIT:C173066 MIO:02147 Any agent that directly binds to and inactivates thrombin (factor IIa), with anticoagulant activity. [url:http://purl.obolibrary.org/obo/NCIT_C173066] direct thrombin inhibitor DTI NCIT:C2578 UMLS:C0019139 MIO:02148 Substances comprised of fragmented heparin molecules derived from unfractionated heparin that bind to antithrombin III with a molecular weight ranging from 1000 to 10,000 daltons, which causes changes in property from unfractionated heparin, including decreased protein binding, enhanced bioavailability, decreased platelet interaction, and decreased binding to thrombin. [url:http://purl.obolibrary.org/obo/NCIT_C2578] low molecular weight heparin LMWH NCIT:C173064 UMLS:C1096489 MIO:02149 Any agent that inhibits the function of vitamin K, with anticoagulant activity. [url:http://purl.obolibrary.org/obo/NCIT_C173064] vitamin K antagonist VKA vitamin K antagonists NCIT:C180619 MIO:02150 An agent taken orally to prevent blood clot formation by directly inhibiting certain coagulation factors including thrombin (factor IIa) or factor Xa. [url:http://purl.obolibrary.org/obo/NCIT_C180619] direct oral anticoagulant DOAC DOACs NOAC direct oral anticoagulants direct-acting oral anticoagulant direct-acting oral anticoagulants novel oral anticoagulant oral anticoagulant CHEBI:61033 NCIT:C73142 UMLS:C0701492 MIO:02151 A synthetic glucopyranoside with antithrombotic activity. Fondaparinux selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development. [url:http://purl.obolibrary.org/obo/NCIT_C73142] fondaparinux ORG 31540 PENTA SR 90107 natural heparin pentasaccharide CHEBI:28304 NCIT:C539 UMLS:C2825026 MIO:02152 A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots. [url:http://purl.obolibrary.org/obo/NCIT_C539] heparin UFH unfractionated heparin NCIT:C77995 UMLS:C1739768 MIO:02153 An orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels. rivaroxaban 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)- 1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide BAY 59-7939 Xarelto NCIT:C80483 MIO:02154 A class of agents that target at platelet ADP receptor or purinergic receptor P2RY12 with antiplatelet activity. [url:http://purl.obolibrary.org/obo/NCIT_C80483] thienopyridine antiplatelet agent platelet ADP receptor antagonist thienopyridine thienopyridines NCIT:C101256 UMLS:C3640054 MIO:02155 A class of agents that act by selectively inhibiting glycoprotein IIb/IIIa with anticoagulant activity. Glycoprotein IIb/IIIa antagonists bind to and block the activation of the platelet-surface integrin glycoprotein IIb/IIIa, thus preventing the binding of fibrinogen and von Willebrand factor leading to the inhibition of platelet activation and aggregation. [url:http://purl.obolibrary.org/obo/NCIT_C101256] glycoprotein IIb/IIIa antagonist GPIIb/IIa antagonist GpIIb/IIIa inhibitors glycoprotein IIb/IIIa inhibitor glycoprotein IIb/IIIa inhibitors MIO:02156 Often a combination of aspirin plus an ADP/P2Y inhibitor (such as clopidogrel, prasugrel, ticagrelor, or another) is used in order to obtain greater effectiveness than with either agent alone. This is known as "dual antiplatelet therapy" (or DAPT). [url:https://en.wikipedia.org/wiki/Antiplatelet_drugDual_antiplatelet_therapy] dual antiplatelet therapy DAPT CHEBI:291902 NCIT:C47516 UMLS:C0253563 MIO:02157 A cyclical heptapeptide with anticoagulant activity. Eptifibatide selectively and reversibly binds to and blocks the platelet glycoprotein IIb/IIIa receptor. This prevents the binding of fibrinogen, von Willebrand factor, and other adhesive ligands and leads to an inhibition of platelet aggregation and prevents thrombus development. [url:http://purl.obolibrary.org/obo/NCIT_C47516] eptifibatide L-Cysteinamide L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-prolyl-, cyclic(1-6)-disulfide N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-prolyl- cyclic(1-6)-disulfide integrilin CHEBI:9605 NCIT:C76405 UMLS:C0247025 MIO:02158 A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time. [url:http://purl.obolibrary.org/obo/NCIT_C76405] tirofiban MK-383 aggrastat-TM NCIT:C49184 UMLS:C3536704 MIO:02159 Any agent belonging to the class of loop diuretics. Loop diuretics block and inhibit the function of the sodium-potassium-chloride (Na+, K+, Cl-) cotransporter system in the thick ascending limb of the loop of Henle, thereby inhibiting the reabsorption of sodium, potassium, and chloride ions. This leads to an increase in the excretion of sodium, potassium, chloride, calcium, magnesium, ammonium and water. [url:http://purl.obolibrary.org/obo/NCIT_C49184] loop diuretic NCIT:C49186 UMLS:C0304490 MIO:02160 Any diuretic agent that produces diuresis without increasing potassium excretion. Potassium sparing diuretics are generally either aldosterone antagonists and thus prevent the aldosterone-mediated promotion of sodium and water retention, or are epithelial sodium channel blockers and prevent the exchange of potassium for sodium in the distal convoluted tubule. These agents cause diuresis without increasing potassium secretion and thus do not cause hypokalemia. [url:http://purl.obolibrary.org/obo/NCIT_C49186] potassium-sparing diuretic OMIT:0001875 MIO:02161 mineralocorticoid receptor antagonist mineralocorticoid receptor antagonists CHEBI:32588 NCIT:C47679 UMLS:C0032825 MIO:02162 A metal halide composed of potassium and chloride. Potassium maintains intracellular tonicity, is required for nerve conduction, cardiac, skeletal and smooth muscle contraction, production of energy, the synthesis of nucleic acids, maintenance of blood pressure and normal renal function. This agent has potential antihypertensive effects and when taken as a nutritional supplement may prevent hypokalemia. [url:http://purl.obolibrary.org/obo/NCIT_C47679] potassium chloride Cena-K K-Lor Klorvess klotrix potasalan potassium chloride slow-K NCIT:C207 MIO:02163 A ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities. Phosphorylated forms of adenosine play roles in cellular energy transfer, signal transduction and the synthesis of RNA. [url:http://purl.obolibrary.org/obo/NCIT_C207] adenosine NCIT:C62002 MIO:02164 An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors. [url:http://purl.obolibrary.org/obo/NCIT_C62002] amiodarone CHEBI:4681 NCIT:C47499 UMLS:C0114771 MIO:02165 A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter. [url:http://purl.obolibrary.org/obo/NCIT_C47499] dofetilide beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)- tikosyn NCIT:C62025 MIO:02166 A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [url:http://purl.obolibrary.org/obo/NCIT_C62025] dopamine 3-Hydroxytyramine dopamina dopaminum oxytyramine NCIT:C2292 MIO:02167 A hormone and neurotransmitter [url:http://purl.obolibrary.org/obo/NCIT_C2292] epinephrine adrenaline XCO:0000127 MIO:02168 Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. [url:https://go.drugbank.com/drugs/DB00368] noradrenaline (R)-norepinephrine L-Norepinephrine L-noradrenaline arterenol nor-adrenaline NCIT:C174672 SNOMED:716068004 MIO:02169 A human immunoglobulin G2 (IgG2) monoclonal antibody directed against human proprotein convertase subtilisin/kexin type 9 (PCSK9), that can be used in the treatment of hypercholesterolemia. Upon administration, evolocumab targets, binds to and inhibits the activity of PCSK9. This prevents binding of PCSK9 to low-density lipoprotein receptor (LDLR) on hepatocytes and prevents its degradation. This increases LDLR on hepatocytes and increases the liver's ability to remove LDL cholesterol (LDL-C) from the blood, thereby lowering LDL-C levels. PCSK9 binds to LDLR on the surface of hepatocytes to promote LDLR degradation within the liver. [url:http://purl.obolibrary.org/obo/NCIT_C174672] evolocumab amg 145 amg-145 amg145 antilipemic agent evolocumab repatha NCIT:C28990 MIO:02170 A drug used to treat irregular heartbeat and some types of heart failure. It is also being studied in the treatment of some types of cancer. Digoxin helps the heart work normally by controlling the amount of calcium that goes into the heart muscle. It also may kill cancer cells and make them more sensitive to anticancer drugs. It is a type of cardiac glycoside. [url:http://purl.obolibrary.org/obo/NCIT_C28990] digoxin 12beta-Hydroxydigitoxin 3beta,12beta,14-Trihydroxy-5beta,14beta-card-20(22)-enolid-3-tridigitoxosid cardiogoxin digoxigenin-tridigitoxosid lanoxin NCIT:C76590 UMLS:C0041037 MIO:02171 An orally available small molecule compound with anti-ischemic, and potential immunomodulating and antineoplastic properties. Although its exact mechanism is not yet fully elucidated, it is postulated that upon administration, trimetazidine selectively inhibits long-chain 3-ketoacyl coenzyme A thiolase (LC 3-KAT), the final enzyme in the free fatty acid (FFA) beta-oxidation pathway. This stimulates glucose oxidation, which requires less oxygen usage and cellular energy than in the beta-oxidation process. This optimizes myocardial energy metabolism and cardiac functioning in an ischemic condition. In cancer cells, the inhibition of fatty acid oxidation (FAO) alters the metabolic processes needed for tumor cell function and proliferation, thereby inducing tumor cell apoptosis. In addition, inhibition of FAO may potentially block the immunosuppressive functions of myeloid-derived suppressor cells (MSDCs), which are thought to promote malignant cell proliferation and migration by inhibiting T-cell function. [url:http://purl.obolibrary.org/obo/NCIT_C76590] trimetazidine vastarel MR NCIT:C29134 UMLS:C0022252 MIO:02172 The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. [url:http://purl.obolibrary.org/obo/NCIT_C29134] isosorbide dinitrate isordil CHEBI:6062 NCIT:C47575 UMLS:C0064079 MIO:02173 The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. [url:http://purl.obolibrary.org/obo/NCIT_C47575] isosorbide mononitrate 1,4:3,6-Dianhydro-D-glucitol 5-nitrate ISMO imdur monoket monosordil NCIT:C47636 MIO:02174 A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation. [url:http://purl.obolibrary.org/obo/NCIT_C47636] nesiritide 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane, Cyclic Peptide Derivative B-type natriuretic peptide human recombinant L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-, Cyclic (10-26)-disulfide human brain natriuretic factor-32 human recombinant-B-type natriuretic peptide natriuretic factor-32 natriuretic peptide type-B recombinant human B-type natriuretic peptide rh-BNP NCIT:C84012 MIO:02175 A niacinamide derivative, a plasma membrane adenosine triphosphate (ATP)-sensitive potassium (K+) (KATP) channel activator and a nitric oxide (NO) donor, with vasodilatory, antihypertensive and potential cardio- and lung-protective activities. Upon administration, nicorandil binds to and opens KATP channels, which causes relaxation of vascular smooth muscles, stimulates vasodilatation, reduces vasoresistance, decreases blood pressure and protects the myocardium against ischemia. In addition, nicorandil exerts nitrate-like properties, through the stimulation of guanylate cyclase, the downregulation of Rho-kinase activity and the further promotion of venous vasodilation. Although the mechanism of action has not been fully elucidated, nicorandil may exhibit protective activity against radiation-induced lung and heart toxicity, possibly by preventing both accumulation of reactive oxygen species (ROS) and ROS-induced cellular damage. [url:http://purl.obolibrary.org/obo/NCIT_C84012] nicorandil 2-nicotinamidoethyl nitrate 3-Pyridinecarboxamide, N-(2-(nitroxy)ethyl)- angedil aprior dancor ikorel nikoran nitorubin sigmart CHEBI:28787 NCIT:C29294 UMLS:C0017887 MIO:02176 An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution. [url:http://purl.obolibrary.org/obo/NCIT_C29294] nitroglycerin rectiv NCIT:C2198 UMLS:C0242937 MIO:02177 Nonopioid agents that produce an analgesic effect, such as NSAIDs. [url:http://purl.obolibrary.org/obo/NCIT_C2198] nonnarcotic analgesic nonopioid CHEBI:37886 NCIT:C87053 UMLS:C0001648 MIO:02178 An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors. The five main categories of adrenergic receptors are: α1, α2, β1, β2, and β3, although there are more subtypes, and agonists vary in specificity between these receptors, and may be classified respectively. However, there are also other mechanisms of adrenergic agonism. Epinephrine and norepinephrine are endogenous and broad-spectrum. More selective agonists are more useful in pharmacology. [url:https://en.wikipedia.org/wiki/Adrenergic_agonist] adrenergic agonist CHEBI:6456 NCIT:C614 UMLS:C0023660 MIO:02179 A synthetic aminoethylamide with local anesthetic and antiarrhythmic properties. Lidocaine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the ionic fluxes required for the initiation and conduction of impulses and effecting local anesthesia. [url:http://purl.obolibrary.org/obo/NCIT_C614] lidocaine .omega.-Diethylamino-2,6-dimethylacetanilide 2-(Diethylamino)-2',6'-acetoxylidide 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide 2-Diethylamino-2',6'-acetoxylidide cuivasil duncaine leostesin lidocaine lidothesin omega-diethylamino-2,6-dimethylacetanilide rucaina CHEBI:17303 NCIT:C62051 UMLS:C0026549 MIO:02180 An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. Morphine binds to and activates specific opiate receptors (delta, mu and kappa), each of which are involved in controlling different brain functions. In the central nervous and gastrointestinal systems, this agent exhibits widespread effects including analgesia, anxiolysis, euphoria, sedation, respiratory depression, and gastrointestinal system smooth muscle contraction [url:http://purl.obolibrary.org/obo/NCIT_C62051] morphine NCIT:C72900 MIO:02181 Any agent that binds to and inhibits adrenergic receptors. [url:http://purl.obolibrary.org/obo/NCIT_C72900] adrenergic antagonist adrenergic blockers adrenergic blocking agent CHEBI:47612 NCIT:C87449 UMLS:C0005330 MIO:02182 An agonist of peroxisome proliferator-activated receptor alpha (PPARalpha) with antilipidemic activity. Bezafibrate decreases triglyceride levels, increases high density lipoprotein (HDL) cholesterol levels, and decreases total and low density lipoprotein (LDL) cholesterol levels. [url:http://purl.obolibrary.org/obo/NCIT_C87449] bezafibrate 2-(4-(2-((4-Chlorobenzoyl)Amino)Ethyl)Phenoxy)-2-Methyl- 2-(p-(2-(p-chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid BM 15.075 bezalip propanoic acid CHEBI:3750 NCIT:C378 UMLS:C0009002 MIO:02183 An aryloxyisobutyric acid derivate with antihyperlipidemic activity. Although the exact mechanism of action has not been fully characterized, clofibrate may enhance the conversion of very-low-density lipoprotein (VLDL) to low-density lipoprotein (LDL), decreasing the production of hepatic VLDL, inhibiting cholesterol production, and increasing fecal excretion of neutral sterols. [url:http://purl.obolibrary.org/obo/NCIT_C378] clofibrate 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester CFB atromid S atromid-S ethyl 2-(4-Chlorophenoxy)-2-methylpropanoate ethyl p-chlorophenoxyisobyturate NCIT:C65653 UMLS:C1880757 MIO:02184 fenirofibrate fenirofibrate NCIT:C29047 MIO:02185 A synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. Fenofibrate is hydrolyzed in vivo to its active metabolite fenofibric acid that binds to and activates peroxisome proliferator activated receptor alpha (PPARalpha), resulting in the activation of lipoprotein lipase and reduction of the production of apoprotein C-III, an inhibitor of lipoprotein lipase activity. Increased lipolysis and a fall in plasma triglycerides, in turn, leads to the modification of the small, dense low density lipoporotein (LDL) particles into larger particles that are catabolized more rapidly due to a greater affinity for cholesterol receptors. In addition, activation of PPARalpha also increases the synthesis of apoproteins A-I, A-II, and high density lipoprotein (HDL)-cholesterol. Overall, fenofibrate reduces total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) while increasing HDL cholesterol. [url:http://purl.obolibrary.org/obo/NCIT_C29047] fenofibrate lofibra tricor CHEBI:5296 NCIT:C29071 UMLS:C0017245 MIO:02186 A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C). [url:http://purl.obolibrary.org/obo/NCIT_C29071] gemfibrozil lopid NCIT:C82243 UMLS:C0064967 MIO:02187 lifibrate lifibrate NCIT:C72998 UMLS:C0074551 MIO:02188 Simfibrate (JAN/INN; trade name Cholesolvin) is a fibrate that has been used for the treatment of hyperlipidemia. [url:https://en.wikipedia.org/wiki/Simfibrate] simfibrate cholesolvin CHEBI:135681 NCIT:C152583 MIO:02189 theofibrate ethophylline clofibrate etofylline clofibrate etophylline clofibrate theofibrate NCIT:C12843 MIO:02190 One of two arteries that arise from the aortic sinuses of the ascending aorta and supply blood to the myocardium [url:http://purl.obolibrary.org/obo/NCIT_C12843] coronary artery coronary artery structure MIO:02191 left anterior descending artery culprit lesion LAD culprit LAD culprit lesion LAD culprit vessel LAD disease LAD infarction LAD infarctions LAD lesions culprit lesion in left anterior descending artery disease of the left anterior descending coronary artery infarct related artery-LAD left anterior descending artery (LAD) disease left anterior descending artery disease left anterior descending artery infarction left anterior descending artery lesion left anterior descending disease left anterior descending-related infarct lesion in left anterior descending artery lesion in the left anterior descending coronary artery PMID:30228908 MIO:02192 left circumflex artery culprit lesion LCX of IRA LCx infarction LCx infarctions culprit left circumflex artery left circumflex artery involvement left circumflex intervention MIO:02193 proximal left anterior descending artery culprit lesion culprit lesion location in the proximal left anterior descending artery lesion in the proximal left anterior descending coronary artery proximal LAD lesion proximal left anterior descending artery lesion PMID:20189566 MIO:02194 light yellow plaque LYP PMID:20189566 MIO:02195 white plaque PMID:20189566 MIO:02196 yellow plaque YP PMID:20189566 MIO:02197 thick yellow plaque TYP dark yellow plaque intensive yellow plaque MIO:02198 U wave inversion inverted U negative U wave MIO:02199 absent U wave absence of a U wave absence of the U wave MIO:02200 A positive U wave deflection was followed by a negative phase. biphasic U wave MIO:02201 grade of ischaemia grade of ischemia PMID:23160859 MIO:02202 P-wave terminal force in lead V1 (PTFV1) is a marker of left atrial abnormalities on the electrocardiogram (ECG).[url:https://pubmed.ncbi.nlm.nih.gov/23160859/] Most studies defined abnormal P-wave terminal force in lead V1 (PTFV1) as ≤ −4000 μV*ms, but some studies it as ≤ −2000 μV*ms. Few normal people have a PTFV1 less than -2000 μV*ms. abnormal P wave terminal force in lead V1 abnormal P-wave terminal force in lead V1 abnormal PTFV1 decreased P-wave terminal force in lead V1 decreased PTFV1 MP:0004071 SNOMED:251205003 MIO:02203 increase in the length of time of the P wave electrical impulses, measured from the beginning to the end of the P wave [ http://www.informatics.jax.org/accession/anna ] [url:http://purl.obolibrary.org/obo/MP_0004071] prolonged P wave increased P wave width MIO:02204 N wave in lead aVL MP:0010515 NCIT:C117770 SNOMED:164917005 MIO:02205 An electrocardiographic finding assessment of new or presumed new pathologic Q waves suggestive of myocardial infarction.[url:http://purl.obolibrary.org/obo/NCIT_C117770] any anomaly in the downward deflection in the ECG occurring after the PR interval that represents depolarization of the interventricular septum [url:http://purl.obolibrary.org/obo/MP_0010515] pathological Q wave Q wave abnormal Q-wave presence abnormal Q wave early QW new Q Wave pathologic Q waves pathological Q waves pathological QW HP:0025076 MIO:02206 Abnormal amplitude of the QRS complex of the electrocardiogram (EKG). [url:http://purl.obolibrary.org/obo/HP_0025076] abnormal QRS voltage MP:0010514 MIO:02207 changes in QRS waveform pattern including different RSR' patterns, additional R waves, notched or absent Q or S wave, or more than one R wave [url:http://purl.obolibrary.org/obo/MP_0010514] fragmented QRS complex QRS complex fragmentation fQRS fragment QRS complex PMID:31571793 MIO:02208 Terminal QRS distortion is defined as a decrease in S-wave amplitude in leads with a terminal S wave and an elevation of the J point > 50% of the height of the R wave amplitude in leads with qR configuration. [url:https://pubmed.ncbi.nlm.nih.gov/31571793/] QRS distortion QRS complex distortion distortion of the terminal portion of the QRS terminal QRS Distortion HP:0001657 MP:0003233 MIO:02209 A prolonged QT interval is a risk factor for ventricular tachyarrhythmias and sudden death. It varies with heart rate and for clinical relevance requires a correction for this, giving the QTc.[url:http://purl.obolibrary.org/obo/MP_0003233] increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave [url:http://purl.obolibrary.org/obo/MP_0003233] prolonged QT interval QT interval prolongation augmented oscillation in QT interval duration increase in QT interval increased QT interval long QT syndrome prolong qt interval on ekg widened QT interval MIO:02210 abnormal QT dispersion abnormal QTd HP:0012250 SNOMED:26141007 SNOMED:429622005 UMLS:C0520887 MIO:02211 An electrocardiographic anomaly in which the ST segment is observed to be located inferior to the isoelectric line. [url:http://purl.obolibrary.org/obo/HP_0012250] ST segment depression ST depression ST segment depression (STD) ST-segment depression STD HP:0012251 UMLS:C0520886 MIO:02212 ST segment elevation may have multiple causes including myocardial infaction, left ventricular aneurysm, and hyperkalemia.[url:http://purl.obolibrary.org/obo/HP_0012251] An electrocardiographic anomaly in which the ST segment is observed to be located superior to the isoelectric line. [url:http://purl.obolibrary.org/obo/HP_0012251] ST segment elevation ST elevation ST-segment elevation PMID:10068843 MIO:02213 An injury pattern was considered present in aVL if any of the following criteria were met: first, ST elevation 2 0.05 mV; second, any lesser degree of ST elevation if associated with symmeuical T-wave inversion; third, any isoelectric ST segment associated with both symmetrical T-wave inversion and an abnormal Q wave (defined as 2 30 ms in duration).[PMID:10068843] ST segment injury pattern in lead aVL HP:0012266 SNOMED:428550008 UMLS:C1998313 MIO:02214 A periodic beat-to-beat variation in the amplitude or shape of the T wave in an EKG. [url:http://purl.obolibrary.org/obo/HP_0012266] T wave alternans T-wave alternans TWA HP:0010872 SNOMED:59931005 UMLS:C0520888 MIO:02215 Inverted T wave is considered abnormal if inversion is deeper than 1.0 mm. Inverted T waves found in leads other than the V1 to V4 leads is associated with increased cardiac deaths. Inverted T waves associated with cardiac signs and symptoms (chest pain and cardiac murmur) are highly suggestive of myocardial ischaemia.[url:https://en.wikipedia.org/wiki/T_wave#Inverted_T_wave] An inversion of the T-wave (which is normally positive). [url:http://purl.obolibrary.org/obo/HP_0010872] T wave inversion Neg-T T wave inversions T-wave inversion T-wave negativity T-wave reinversion inverted T wave negative T wave reinverted T wave PMID:32568742 MIO:02216 T-wave precordial instability was defined as upright T-wave in V1>V6。 [url:https://pubmed.ncbi.nlm.nih.gov/32568742/] T wave precordial instability T-wave precordial instability NCIT:C27470 MIO:02217 Cancer that is spread throughout the body, a metastatic phenomenon. [url:http://purl.obolibrary.org/obo/NCIT_C27470] disseminated malignant neoplasm disseminated cancer NCIT:C127155 MIO:02218 A malignant solid neoplasm that has spread from its original site of growth to another anatomic site. [url:http://purl.obolibrary.org/obo/NCIT_C127155] metastatic malignant solid neoplasm metastatic malignant solid tumor metastatic solid neoplasm metastatic solid tumor metastatic tumor NCIT:C62605 MIO:02219 A microvascular coagulopathy that may result from systemic vascular endothelial injury triggering the development of a procoagulant state, activation of the complement cascade, and microthrombi formation. Signs may include hemolytic anemia, thrombocytopenia, hypertension and renal dysfunction. [url:http://purl.obolibrary.org/obo/NCIT_C62605] thrombotic microangiopathy TMA thrombotic microangiopathies NCIT:C78797 MIO:02220 A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition. A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction. [url:http://purl.obolibrary.org/obo/NCIT_C78797] thrombotic thrombocytopenic purpura TTP moschowitz disease NCIT:C26732 MIO:02221 Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C26732] coronary artery disease CAD CHD coronary artery diseases coronary artery disorder coronary artery disorders coronary disease coronary heart disease disease of coronary artery disease or disorder of coronary artery NCIT:C35544 SNOMED:57809008 MIO:02222 A disorder that affects the muscle tissue of the heart. Representative examples include myocardial infarction, myocarditis, and cardiomyopathy. [url:http://purl.obolibrary.org/obo/NCIT_C35544] myocardial disease disorder of heart muscle disorder of myocardium myocardial disorder NCIT:C99538 MIO:02223 An anatomic deformity of the heart, ventricles or great vessels [url:http://purl.obolibrary.org/obo/NCIT_C99538] structural heart disease structural disorder of heart structural heart abnormality NCIT:C45525 UMLS:C2673553 MIO:02224 Any heart disorder characterized by a defect in valve structure or function. [url:http://purl.obolibrary.org/obo/NCIT_C45525] valvular heart disorder disorder of heart valve heart valve disease valvular heart disease NCIT:C78245 UMLS:C4011764 MIO:02225 A disorder affecting the conduction system that sends electrical signals in the myocardium. [url:http://purl.obolibrary.org/obo/NCIT_C78245] cardiac conduction disorder conduction disorder disorder of cardiac conduction heart conduction disorder MONDO:0000473 MIO:02226 An impairment of the structure or function of the blood vessels which carry blood away from the heart. [url:http://purl.obolibrary.org/obo/MONDO_0000473] arterial disorder arterial disease arteriopathy artery disease artery disease or disorder disease of artery disease or disorder of artery disorder of artery NCIT:C26759 MIO:02227 The blockage of a blood vessel lumen by air or solid material such as blood clot or other tissues (e.g., adipose tissue, cancer cells) that have migrated from another anatomic site. [url:http://purl.obolibrary.org/obo/NCIT_C26759] embolism embolus PMID:33442854 MIO:02228 Microvascular injury may include microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH). Reperfusion of the infarcted artery leads to ultrastructural and functional changes at the microvascular level, including platelet and inflammatory cell activation, vasospasm and reperfusion damage to the endothelium. [url:https://pubmed.ncbi.nlm.nih.gov/33442854/] microvascular injury OMIT:0016186 MIO:02229 myocardial injury myocardial damage MONDO:0043218 MIO:02230 A disorder of the nervous system related to a vascular etiology. [url:http://purl.obolibrary.org/obo/MONDO_0043218] neurovascular disease disease of nervous system vasculature nervous system disorder of vasculature neurovascular disorder vasculature nervous system disorder COHD:321052 DOID:341 EFO:0003875 MESH:D001157 MESH:D016491 MONDO:0005294 NCIT:C35136 PMID:22279115 PMID:29083808 PMID:32829713 PMID:9034940 SNOMED:195624006 SNOMED:2929001 UMLS:C0003838 UMLS:C0031115 MIO:02231 Any disorder affecting blood flow through the veins or arteries outside of the heart. [url:http://purl.obolibrary.org/obo/MONDO_0005294] peripheral vascular disease PVD arterial occlusive disease peripheral angiopathies peripheral angiopathy peripheral vascular diseases peripheral vascular disorder NCIT:C99938 MIO:02232 A longstanding, complete blockage of a vessel. [url:http://purl.obolibrary.org/obo/NCIT_C99938] chronic total occlusion vessel CTO chronic total occlusion SNOMED:39785005 MIO:02233 pulmonary circulation disorder disorder of pulmonary circulation pulmonary circulation disorders NCIT:C123221 MIO:02234 Narrowing of a main artery in the kidney. [url:http://purl.obolibrary.org/obo/NCIT_C123221] renal artery stenosis RAS narrowing of kidney artery NCIT:C72070 MIO:02235 A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension. [url:http://purl.obolibrary.org/obo/NCIT_C72070] systemic scleroderma diffuse scleroderma diffuse sclerosis systemic sclerosis NCIT:C84564 MIO:02236 An immune-mediated disease characterized by inflammation in the axial skeleton including sacroiliac joints, vertebrae and vertebral joints. Peripheral joints may be involved as well. Clinical features can include low back pain and stiffness, limited motion of the lumbar spine, and limited chest expansion. [url:http://purl.obolibrary.org/obo/NCIT_C84564] ankylosing spondylitis NCIT:C34650 OMIT:0007260 MIO:02237 A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals. [url:http://purl.obolibrary.org/obo/NCIT_C34650] gout gout attack NCIT:C61277 MIO:02238 An inflammatory arthritis typically associated with dactylitis, nail dystrophy, and the absence of rheumatoid factor in an individual with psoriasis or a family history of psoriasis. [url:http://purl.obolibrary.org/obo/NCIT_C61277] psoriatic arthritis PsA arthritis psoriatica psoriatic arthropathy DOID:7148 EFO:0000685 MONDO:0008383 MeSH:D001172 NCIT:C2884 OMIM:180300) UMLS:C0003873 MIO:02239 A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor. [url:http://www.ebi.ac.uk/efo/EFO_0000685] rheumatoid arthritis RA arthritis or polyarthritis, rheumatic arthritis, rheumatoid atrophic arthritis autoimmune arthritis chronic rheumatic arthritis proliferative arthritis rheumatic gout rheumatoid disease SNOMED:55464009 MIO:02240 A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. [url:http://purl.obolibrary.org/obo/HP_0002725] systemic lupus erythematosus SLE disseminated lupus erythematosus HP:0008223 MIO:02241 Condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4). [url:http://purl.obolibrary.org/obo/HP_0008223] compensated hypothyroidism mild hypothyroidism subclinical hypothyroidism DOID:0050589 EFO:0003767 MIO:02242 An intestinal disease characterized by inflammation located in all parts of digestive tract. [url:http://purl.obolibrary.org/obo/DOID_0050589] inflammatory bowel disease inflammatory bowel disease (IBD) MIO:02243 Tannerella forsythia is an anaerobic, Gram-negative bacterial species of the Cytophaga-Bacteroidetes family. It has been implicated in periodontal diseases and is a member of the red complex of periodontal pathogens.[url:https://en.wikipedia.org/wiki/Tannerella_forsythia] oral infections of tannerella forsythia NCIT:C34463 MIO:02244 An infection that is caused by Chlamydia trachomatis. [url:http://purl.obolibrary.org/obo/NCIT_C34463] chlamydial infection Cp infection chlamydia chlamydia pneumoniae infection NCIT:C39293 MIO:02245 A bacterial infection of the stomach, caused by Helicobacter pylori. It is associated with the development of peptic ulcer and mucosa-associated lymphoid tissue lymphoma. [url:http://purl.obolibrary.org/obo/NCIT_C39293] helicobacter pylori infection H. pylori H. pylori infection Helicobacter pylori helicobacter pylori-seropositivity NCIT:C86657 PMID:15616414 MIO:02246 A species of obligately anaerobic, Gram-negative, rod shaped bacteria assigned to the phylum Bacteroidetes. This species is nonmotile, non-spore forming, indole and trypsin positive, alpha-fucosidase negative, pigmented, nonfermenting, utilizes trypticase, proteose, and peptone as a source of energy, and does not reduce nitrate or hydrolyze starch or esculin. P. gingivalis is associated with periodontal disease. [url:http://purl.obolibrary.org/obo/NCIT_C86657] porphyromonas gingivalis infection P. gingivalis bacteroides gingivalis porphyromonas gingivalis MIO:02247 Postpartum infections, also known as childbed fever and puerperal fever, are any bacterial infections of the female reproductive tract following childbirth or miscarriage. Signs and symptoms usually include a fever greater than 38.0 °C (100.4 °F), chills, lower abdominal pain, and possibly bad-smelling vaginal discharge. It usually occurs after the first 24 hours and within the first ten days following delivery. [url:https://en.wikipedia.org/wiki/Postpartum_infections] postpartum infections childbed fever postpartum infection puerperal fever SNOMED:195647007 MIO:02248 acute respiratory infection acute respiratory tract infection NCIT:C27219 MIO:02249 A respiratory tract infection caused by a virus. Viruses represent the most common causes of upper and lower respiratory tract infections and include rhinoviruses, influenza viruses, parainfluenza viruses, and respiratory syncytial virus. [url:http://purl.obolibrary.org/obo/NCIT_C27219] viral respiratory tract infection NCIT:C111915 MIO:02250 Clinical syndrome defined by the presence of both infection and a systemic inflammatory response that progresses to multi-organ failure. [url:http://purl.obolibrary.org/obo/NCIT_C111915] severe sepsis sepsis with organ dysfunction NCIT:C3108 MIO:02251 An infection caused by the human immunodeficiency virus. [url:http://purl.obolibrary.org/obo/NCIT_C3108] HIV infection PLWH human immunodeficiency virus human immunodeficiency virus infection DOID:0080600 MIO:02252 A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2. [url:http://purl.obolibrary.org/obo/DOID_0080600] COVID-19 2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 infectious disease MONDO:0005132 MIO:02253 A herpesvirus infection caused by Cytomegalovirus. Healthy individuals generally do not produce symptoms. However, the infection may be life-threatening in affected immunocompromised patients. The virus may cause retinitis, esophagitis, gastritis, and colitis. Morphologically, it is characterized by the presence of intranuclear inclusion bodies. [url:http://purl.obolibrary.org/obo/MONDO_0005132] cytomegalovirus infection EFO:0007255 OMIT:0006011 MIO:02254 An disease caused by infection with Enterovirus. [url:http://www.ebi.ac.uk/efo/EFO_0007255] enterovirus infections disease due to enterovirus enterovirus caused disease or disorder enterovirus disease or disorder enterovirus infection enterovirus infectious disease EFO:0003047 NCIT:C3098 MIO:02255 A viral infection caused by the hepatitis C virus. [url:http://purl.obolibrary.org/obo/NCIT_C3098] hepatitis C virus infection HCV infection NANBH hepatitis C hepatitis C infection non-A, nNon-B hepatitis NCIT:C53482 MIO:02256 An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system. [url:http://purl.obolibrary.org/obo/NCIT_C53482] influenza Flu IV infection influenza virus infection DOID:784 ICD11:GB61 MESH:D007676 NCIT:C80078 NCIT:C9438 PMID:32829713 SNOMED:155856009 UMLS:C0022661 UMLS:C1561643 MIO:02257 Impairment of the renal function secondary to chronic kidney damage persisting for three or more months [url:http://purl.obolibrary.org/obo/NCIT_C80078] chronic kidney disease CKD CRD CRF chronic renal disease chronic renal failure chronic renal failure syndrome chronic renal insufficiency chronic-phase worsening renal function SNOMED:312975006 MIO:02258 greater than the normal amount of microalbumin in the urine [url:http://purl.obolibrary.org/obo/MP_0002959] microalbuminuria increased microalbumin excretion increased urine microalbumin level NCIT:C28397 MIO:02259 A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways. [url:http://purl.obolibrary.org/obo/NCIT_C28397] asthma DOID:3083 EFO:0000341 ICD11:CA22 MESH:D029424 NCIT:C3199 OMIM:606963 PMID:22279115 PMID:22537796 PMID:32829713 SNOMED:13645005 UMLS:C0024117 MIO:02260 Chronic Obstructive Pulmonary disease (COPD), a common preventable and treatable disease, is characterised by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Exacerbations and comorbidities contribute to the overall severity in individual patients. [url:http://id.who.int/icd/entity/133207228] chronic obstructive pulmonary disease COLD COPD chronic obstructive airway disease chronic obstructive lung disease NCIT:C27043 MIO:02261 Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It manifests with dyspnea and cyanosis and may lead to cardiovascular shock. [url:http://purl.obolibrary.org/obo/NCIT_C27043] acute respiratory failure NCIT:C35010 MIO:02262 Abnormally low concentrations of vitamin C in the blood. [url:http://purl.obolibrary.org/obo/NCIT_C35010] vitamin C deficiency scurvy NCIT:C114830 MIO:02263 Abnormally low level of 25-hydroxyvitamin D in the blood. [url:http://purl.obolibrary.org/obo/NCIT_C114830] vitamin D deficiency vitamin D insufficiency EFO:0003774 MP:0001548 MIO:02264 abnormally high concentration of lipids in the circulating blood [url:http://purl.obolibrary.org/obo/MP_0001548] hyperlipidemia hyperlipemia hyperlipidemia hyperlipidemias lipemia lipemias lipidemias NCIT:C37976 OMIT:0008143 MIO:02265 Lower than normal levels of sodium in the circulating blood. A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood. Abnormally low level of sodium in the blood. [url:http://purl.obolibrary.org/obo/NCIT_C37976] hyponatremia HP:0001952 MIO:02266 Glucose intolerance (GI) can be defined as dysglycemia that comprises both prediabetes and diabetes. It includes the conditions of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and diabetes mellitus (DM). [url:http://purl.obolibrary.org/obo/HP_0001952] glucose intolerance AGR AGT abnormal glucose regulation abnormal glucose tolerance NCIT:C3514 SNOMED:6962006 MIO:02267 Retinopathy due to hypertension. [url:http://purl.obolibrary.org/obo/NCIT_C3514] hypertensive retinopathy hypertensive retinopathy NCIT:C34848 PMID:20031840 UMLS:C0027932 MIO:02268 A form of functional mental illness that manifests in distressed emotional reactions such as anxiety, obsessive thoughts, compulsive behaviors, or irrational fears. [url:http://purl.obolibrary.org/obo/NCIT_C34848] neurosis NCIT:C92621 MIO:02269 An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by dissociative symptoms; vivid recollections of the traumatic event; avoidance of stimuli associated with the traumatic event; and a constant state of hyperarousal for no more than one month. [url:http://purl.obolibrary.org/obo/NCIT_C92621] acute stress disorder ASD NCIT:C92622 MIO:02270 An anxiety disorder characterized by excessive and difficult-to-control worry about a number of life situations. The worry is accompanied by restlessness, fatigue, inability to concentrate, irritability, muscle tension, and/or sleep disturbance and lasts for at least 6 months. A condition marked by excessive worry and feelings of fear, dread, and uneasiness that last six months or longer. Other symptoms of GAD include being restless, being tired or irritable, muscle tension, not being able to concentrate or sleep well, shortness of breath, fast heartbeat, sweating, and dizziness. [url:http://purl.obolibrary.org/obo/NCIT_C92622] generalized anxiety disorder GAD NCIT:C34890 MIO:02271 An anxiety disorder characterized by multiple unexpected panic attacks with persistent concern of recurring attacks. Panic disorder may or may not be accompanied by agoraphobia. [url:http://purl.obolibrary.org/obo/NCIT_C34890] panic disorder NCIT:C35420 MIO:02272 An anxiety disorder characterized by an intense, irrational fear of an object, activity, or situation. The individual seeks to avoid the object, activity, or situation. In adults, the individual recognizes that the fear is excessive or unreasonable. [url:http://purl.obolibrary.org/obo/NCIT_C35420] phobia NCIT:C34423 PMID:20031840 UMLS:C0005586 MIO:02273 A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression. [url:http://purl.obolibrary.org/obo/NCIT_C34423] bipolar disorder bipolar disorders manic depressive disorder manic-depression NCIT:C78576 UMLS:C4012112 MIO:02274 A severe mental disorder in which a person loses the ability to recognize reality or relate to others. The person is not able to cope with the demands of everyday life. Symptoms include being paranoid, having false ideas about what is taking place or who one is, and seeing, hearing, or feeling things that are not there. A mental state characterized by impaired reality which may include perceptual disturbances, abnormal beliefs and disorganized thinking. A disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor. [url:http://purl.obolibrary.org/obo/NCIT_C78576] psychosis NCIT:C94378 PMID:20031840 MIO:02275 A disorder in which the individual suffers from both symptoms that qualify as schizophrenia and symptoms that qualify as a mood disorder (e.g., depression or bipolar disorder) for a substantial portion (but not all) of the active period of the illness; for the remainder of the active period of the illness, the individual suffers from delusions or hallucinations in the absence of prominent mood symptoms. [url:http://purl.obolibrary.org/obo/NCIT_C94378] schizoaffective disorder schizoaffective disorders NCIT:C3362 PMID:20031840 UMLS:C3553161 MIO:02276 A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality. [url:http://purl.obolibrary.org/obo/NCIT_C3362] schizophrenia PMID:30371311 MIO:02277 CRS type 1 (CRS1) is characterized by acute worsening of heart function leading to acute kidney injury (AKI). [url:https://pubmed.ncbi.nlm.nih.gov/30371311/] cardiorenal syndrome type 1 CRS type 1 CRS1 type 1 cardio-renal syndrome EFO:0003149 MIO:02278 Patients with advanced heart failure have severe limitations, experiences symptoms even while at rest and are mostly bedbound patients. [url:http://www.ebi.ac.uk/efo/EFO_0003149] advanced heart failure ACC Stage D NYHA class IV ICD11:ME24.9Z PMID:22108447 MIO:02279 upper gastrointestinal bleeding SNOMED:27719009 MIO:02280 acute gastrointestinal hemorrhage acute GI bleeding acute GI haemorrhage acute GI hemorrhage acute gastrointestinal bleeding acute gastrointestinal haemorrhage EFO:0005669 ICD11:8B00 NCIT:C50485 PMID:1899364 SNOMED:274100004 UMLS:C2937358 MIO:02281 Bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. [url:http://www.ebi.ac.uk/efo/EFO_0005669] cerebral hemorrhage bleeding in brain cerebral bleeding cerebral bleedings cerebral haemorrhage intracerebral haemorrhage intracerebral hemorrhage parenchymatous hemorrhage HP:0025420 PMID:15255470 MIO:02282 A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen. [url:http://purl.obolibrary.org/obo/HP_0025420] diffuse alveolar hemorrhage diffuse alveolar haemorrhage diffuse intra-alveolar haemorrhage PMID:12227717 PMID:14993896 PMID:9586930 MIO:02283 Spinal epidural hematoma is bleeding into the epidural space in the spine. These may arise spontaneously (e.g. during childbirth), or as a rare complication of epiduralanaesthesia or of surgery (such as laminectomy). [url:https://en.wikipedia.org/wiki/Spinal_epidural_hematoma] spinal epidural hematoma spinal epidural haematoma ICD11:ME00 PMID:17162553 SNOMED:427207001 MIO:02284 Abdominal compartment syndrome is a condition of organ dysfunction caused by increased intra-abdominal pressure (intra-abdominal hypertension), possibly due to intra-abdominal haemorrhage, retroperitoneal haematoma, or intestinal oedema, often occurred after surgical intervention or trauma, or often associated with septic condition. The importance of this clinical entity was recognised recently in the end of the 20th Century. Usually the abdominal distension due to primary ischaemic bowel injury was excluded from this clinical entity. [url:http://id.who.int/icd/entity/918157973] abdominal compartment syndrome PMID:7963391 PMID:8070154 SNOMED:212381005 MIO:02285 compartment syndrome of forearm forearm compartment syndrome SNOMED:212382003 MIO:02286 compartment syndrome of hand hand compartment syndrome PMID:12455731 SNOMED:212380006 MIO:02287 compartment syndrome of upper arm tricep compartment syndrome HP:0011623 MIO:02288 The trabecular septum is the largest part of the interventricular septum. It extends from the membranous septum to the apex and superiorly to the infundibular septum. A defect in the trabecular septum is called muscular VSD if the defect is completely rimmed by muscle. [ http://www.ncbi.nlm.nih.gov/pubmed/17101870 DDD:dbrown ] [url:http://purl.obolibrary.org/obo/HP_0011623] muscular ventricular septal defect type 4 ventricular septal defect HP:0011621 PMID:28705049 MIO:02289 A type of ventricular septal defect communicating directly between the left ventricle and right atrium. This is anatomically possible because the normal tricuspid valve is more apically displaced than the mitral valve. [url:http://purl.obolibrary.org/obo/HP_0011621] Gerbode ventricular septal defect acquired Gerbode defect left ventricular - right atrial communication HP:0011622 MIO:02290 A ventricular septal defect that involves the inlet of the right ventricular septum immediately inferior to the AV valve apparatus. [ http://www.ncbi.nlm.nih.gov/pubmed/17101870 DDD:dbrown ] [url:http://purl.obolibrary.org/obo/HP_0011622] inlet ventricular septal defect AV Canal type VSD AV septum-type ventricular septum defect VSD, type 3 canal-type ventricular septal defect endocardial cushion-type ventricular septal defect inlet-type ventricular septal defect juxtatricuspid ventricular septal defect posterior ventricular septal defect type 3 ventricular septal defect ventricular septal defect, ECD type SNOMED:410022000 MIO:02291 Femoral pseudoaneurysms may complicate up to 8% of vascular interventional procedures. Small pseudoaneurysms can spontaneously clot, while others need definitive treatment. [url:https://en.wikipedia.org/wiki/Pseudoaneurysm] femoral pseudoaneurysm femoral pseudoaneurysm after arterial catheterisation femoral pseudoaneurysm after arterial catheterization femoral pseudoaneurysms post-catheterisation femoral false aneurysm post-catheterization femoral false aneurysm PMID:34126755 PMID:4842750 SNOMED:443089001 MIO:02292 A pseudoaneurysm may also occur in a chamber of the heart following myocardial damage due to ischemia or trauma. A pseudoaneurysm of the left ventricle is a potentially lethal complication from a myocardial infarction. [url:https://en.wikipedia.org/wiki/Pseudoaneurysm] left ventricular pseudoaneurysm pseudo-pseudoaneurysm of the left ventricle HP:0006698 ICD11:BA60.2 NCIT:C27140 SNOMED:90539001 MIO:02293 A discrete dyskinetic area of the left ventricular wall with a broad neck after acute myocardial infarction. The wall of the true aneurysm is thinner than the rest of the left ventricle; it is usually composed of fibrous tissue and necrotic muscle, occasionally mixed with viable myocardium. In contrast, pseudoaneurysms are composed of organised hematoma and pericardium and lack any elements of the original myocardial wall. [url:http://id.who.int/icd/entity/456973650] ventricular aneurysm NCIT:C168176 MIO:02294 Focal dilation of a coronary artery secondary to arterial wall weakening. [url:http://purl.obolibrary.org/obo/NCIT_C168176] coronary artery aneurysm CAA NCIT:C27046 MIO:02295 A ruptured aneurysm located in the portion of the descending aortic wall that is within the abdomen. [url:http://purl.obolibrary.org/obo/NCIT_C27046] ruptured abdominal aortic aneurysm ruptured AAA PMID:3565229 PMID:4080165 PMID:6496295 MIO:02296 free ventricular wall rupture cardiac free-wall rupture free wall rupture free-wall rupture rupture of free ventricular wall rupture of the ventricular free wall ventricular free wall rupture ventricular rupture ICD11:BA60.6 PMID:32428100 PMID:33346367 SNOMED:194866002 MIO:02297 mitral chordae tendineae rupture mitral valve chordae tendineae rupture rupture of mitral chordae tendineae ICD11:BA60.6 PMID:21387617 PMID:31948978 PMID:33346367 SNOMED:5919001 MIO:02298 Papillary muscle rupture almost always leads to cardiogenic shock and carries a mortality in the range of 80% to 90%. A total rupture of the entire papillary muscle trunk is generally viewed to be incompatible with life.[url:https://pubmed.ncbi.nlm.nih.gov/443647/] Papillary muscle rupture is one of the catastrophic mechanical complications of myocardial infarction (MI) resulting in a flail mitral valve leaflet causing severe mitral regurgitation, pulmonary oedema and cardiogenic shock. Survival depends on early recognition and intervention surgically. [url:https://pubmed.ncbi.nlm.nih.gov/31948978/] papillary muscle rupture rupture of papillary muscle NCIT:C34669 MIO:02299 Tearing of the heart muscle as a sequela of acute myocardial infarction. [url:http://purl.obolibrary.org/obo/NCIT_C34669] post infarct cardiac rupture infarct rupture PMID:14249987 PMID:17530564 PMID:4704432 PMID:5736152 SNOMED:3098007 MIO:02300 Rupture of the interventricular septum is an uncommon complication of cardiac infarction. [url:https://pubmed.ncbi.nlm.nih.gov/13269605/] ventricular septal rupture VSP interventricular septal perforation interventricular septum rupture rupture of the interventricular septum ruptured interventricular septum ventricular septal perforation HP:0001653 MIO:02301 An abnormality of the mitral valve characterized by insufficiency or incompetence of the mitral valve resulting in retrograde leaking of blood through the mitral valve upon ventricular contraction. [url:http://purl.obolibrary.org/obo/HP_0001653] mitral regurgitation mitral valve regurgitation PMID:28733995 MIO:02302 Early ST was defined at ST within 30 days of coronary stent deployment. [url:https://pubmed.ncbi.nlm.nih.gov/28733995/] early stent thrombosis early ST MIO:02303 Late stent thrombosis is defined as the occurrence of thrombosis above 30 days after stent implantation. late stent thrombosis late ST PMID:32558694 MIO:02304 A large thrombus burden was defined as a definite thrombus with the largest dimension of at least two vessel diameters [thrombolysis in myocardial infarction (TIMI) thrombus grades 4 and 5]. [url:https://pubmed.ncbi.nlm.nih.gov/32558694/] high thrombus burden HTB high coronary thrombus burden high intracoronary thrombus burden large thrombus burden PMID:31544899 MIO:02305 According to thrombus grade the patients were grouped as low thrombus burden (grades 0-3) and high thrombus burden (grades 4 and 5). [url:https://pubmed.ncbi.nlm.nih.gov/31544899/] low thrombus burden LTB NCIT:C99107 MIO:02306 The formation of a blood clot (thrombus) in the lumen of a vein. [url:http://purl.obolibrary.org/obo/NCIT_C99107] venous thrombosis HP:0025168 MIO:02307 Abnormal function of the left ventricule during left ventricular relaxation and filling. Diastolic left ventricular disease can cause of limitation of exercise tolerance, whether or not ejection fraction is normal. This feature can be assessed by cardiac imaging. [url:http://purl.obolibrary.org/obo/HP_0025168] left ventricular diastolic dysfunction LV diastolic dysfunction diastolic dysfunction impaired diastolic functional recovery impaired left ventricular diastolic function HP:0025169 NCIT:C64251 MIO:02308 The degree of impairment of the left cardiac ventricle to contract efficiently. A disorder characterized by failure of the left ventricle to produce adequate output despite an increase in distending pressure and in end-diastolic volume. Clinical manifestations may include dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema. [url:http://purl.obolibrary.org/obo/NCIT_C64251] left ventricular systolic dysfunction LVSD cardiac systolic dysfunction depressed left ventricular systolic function impaired LV contractility left cardiac ventricular systolic dysfunction left ventricular systolic failure poor left ventricular systolic function systolic dysfunction HP:0012664 MIO:02309 The normal range is at least 50 percent.[url:http://purl.obolibrary.org/obo/HP_0012664] reduced left ventricular ejection fraction LVEF drop decrease of left ventricular ejection fraction decreased LVEF decreased left ventricular ejection fraction depressed LVEF depressed left ventricular ejection fraction deterioration of LVEF deterioration of left ventricular ejection fraction impaired LVEF impaired left ventricular ejection fraction low LVEF low left ventricular ejection fraction reduced LVEF reduced ejection fraction SNOMED:416158002 MIO:02310 right ventricular systolic dysfunction RV systolic dysfunction SNOMED:161504004 MIO:02311 history of angina pectoris history of angina pre-infarction angina preinfarction angina SNOMED:275526006 MIO:02312 history of cerebrovascular accident previous cerebrovascular accident prior cerebrovascular accident SNOMED:161511000 MIO:02313 history of transient ischaemic attack history of transient ischemic attack SNOMED:160579004 MIO:02314 stopped drinking alcohol stopping alcohol drinking NCIT:C126384 SNOMED:86933000 MIO:02315 A man who drinks more than 14 standard drinks per week or a woman who drinks more than 7 standard drinks per week. [url:http://purl.obolibrary.org/obo/NCIT_C126384] heavy drinker drinks heavily heavy drinkers heavy episodic drinking NCIT:C67148 MIO:02316 A person who has quit smoking at the time of the interview but has smoked at least 100 cigarettes in their life. [url:http://purl.obolibrary.org/obo/NCIT_C67148] former smoker ex-smoker ex-smokers former smokers former smoking former-smoking prior smoker prior smokers prior smoking NCIT:C65108 MIO:02317 A person who has never smoked at the time of the interview or has smoked less than 100 cigarettes in their life. [url:http://purl.obolibrary.org/obo/NCIT_C65108] never smoker never smoked never smokers never smoking never-smokers no previous tobacco use non-smoker SNOMED:228493008 MIO:02318 ex-snuff user ever snuff user ever snuff users ex-snuff users former snuff user former snuff users SNOMED:228494002 MIO:02319 snuff user current snuff user current snuff users NCIT:C164167 MIO:02320 A person who uses a vaping device at the present time. [url:http://purl.obolibrary.org/obo/NCIT_C164167] current vaper current electronic cigarrete use MIO:02321 former vaper former e-cigarette use former electronic cigarette use SNOMED:429074009 MIO:02322 history of cardiovascular surgery NCIT:C102642 MIO:02323 An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by two or more consecutive non-conducted P waves. [url:http://purl.obolibrary.org/obo/NCIT_C102642] high-degree atrioventricular block HAVB advanced atrioventricular block advanced/high grade AV block high degree AVB high degree atrioventricular (AV) block high grade atrioventricular block high-degree AV block HP:0011705 ICD11:BC63.0 NCIT: C62015 SNOMED:270492004 UMLS:C0085614 MIO:02324 Delay of conduction through the atrioventricular node, which is manifested as prolongation of the PR interval in the electrocardiogram (EKG). All atrial impulses reach the ventricles. [url:http://purl.obolibrary.org/obo/HP_0011705] first degree atrioventricular block AV block first degree first degree heart block incomplete atrioventricular block, first degree PMID:30022507 MIO:02325 inter-atrial block interatrial block HP:0011710 ICD11:BC63.5 MSH:D002037 NCIT:C84603 PMID:30341846 SNOMED:6374002 UMLS:C0006384 MIO:02326 Block of conduction of electrical impulses along the Bundle of His or along one of its bundle branches. [url:http://purl.obolibrary.org/obo/HP_0011710] bundle branch block BBB DOID:0060224 HP:0005110 ICD11:BC81.3 MESH:D001281 NCIT:C50466 PMID:10704162 PMID:29988239 PMID:30233710 PMID:33903847 PMID:976100 SNOMED:49436004 UMLS:C0004238 MIO:02327 An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute. [url:http://purl.obolibrary.org/obo/HP_0005110] atrial fibrillation ICD11:BC61 PMID:3769957 SNOMED:81681009 MIO:02328 junctional premature beats ectopic junctional beats junctional ectopic contractions junctional premature beat premature junctional contractions HP:0004763 MIO:02329 An episodic form of supraventricular tachycardia with abrupt onset and termination. [ http://www.ncbi.nlm.nih.gov/pubmed/18025404 ] [url:http://purl.obolibrary.org/obo/HP_0004763] paroxysmal supraventricular tachycardia episodic supraventricular tachycardia HP:0031676 MIO:02330 A type of ventricular tachycardia that is characterized by uniform QRS complexes within each lead (i.e., each QRS is identical or nearly so). [url:http://purl.obolibrary.org/obo/HP_0031676] monomorphic ventricular tachycardia MVT SNOMED:426525004 MIO:02331 If the rhythm lasts more than 30 seconds, it is known as a sustained ventricular tachycardia (even if it terminates on its own after 30 seconds). [url:https://en.wikipedia.org/wiki/Ventricular_tachycardia] sustained ventricular tachycardia sustained VT NCIT:C62266 SNOMED:61277005 MIO:02332 An electrocardiographic finding of idioventricular rhythm with a rate greater than 50 beats per minute. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C62266] accelerated idioventricular rhythm AIVR slow ventricular tachycardia SNOMED:233907003 MIO:02333 induced ventricular tachycardia inducible VT inducible ventricular tachycardia SNOMED:444658006 MIO:02334 nonsustained ventricular tachycardia NSVT non-sustained ventricular tachycardia MIO:02335 induced ventricular fibrillation inducible VF inducible ventricular fibrillation SNOMED:429243003 MIO:02336 sustained ventricular fibrillation sustained VF NCIT:C167482 MIO:02337 The location of the radiating chest pain is in the abdomen. [url:http://purl.obolibrary.org/obo/NCIT_C167482] radiating chest pain to the abdomen abdominal pain radiating chest pain in abdomen PMID:16020420 MIO:02338 The location of the radiating chest pain is in the arm. radiating chest pain to the arm arm pain discomfort in arms radiating chest pain in arm PMID:31465031 MIO:02339 The location of the radiating chest pain is in the occlusalf surface. radiating chest pain to the occlusalf surface orofacial pain MIO:02340 The location of the radiating chest pain is in the shoulder. radiating chest pain to the shoulder discomfort in shoulder pain in shoulder radiating chest pain in shoulder shoulder pain NCIT:C167483 PMID:11182180 MIO:02341 The location of the radiating chest pain is in the back. [url:http://purl.obolibrary.org/obo/NCIT_C167483&ns=ncit] radiating chest pain to the back back pain radiating chest pain in back PMID:11182180 PMID:12453034 PMID:16020420 MIO:02342 The location of the radiating chest pain is in the head. radiating chest pain to the headache headache headaches radiating chest pain in headache NCIT:C167485 PMID:11182180 MIO:02343 The location of the radiating chest pain is in the neck. [url:http://purl.obolibrary.org/obo/NCIT_C167485&ns=ncit] radiating chest pain to the neck neck pain radiating chest pain in neck NCIT:C167486 MIO:02344 The location of the radiating chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides. [url:http://purl.obolibrary.org/obo/NCIT_C167486&ns=ncit] radiating chest pain to the sternum pain behind the sternum radiating chest pain in sternum retrosternal pain substernal chest pain PMID:31465031 MIO:02345 radiating chest pain to the tooth dental pain radiating chest pain in tooth toothache MIO:02346 electrophysiological biomarker electrophysiological biomarkers electrophysiological marker electrophysiological markers PMID:33620437 MIO:02347 thrombin measurement thrombin thrombin generation thrombin generation test NCIT:C17544 MIO:02348 Tissue inhibitors of metalloproteinase. A family of proteins of around 200 residues that can inhibit enzymes of the metalloprotease type, for example collagenase, by binding to them. [url:http://purl.obolibrary.org/obo/NCIT_C17544] tissue inhibitor of metalloproteinases TIMP EFO:0007776 NCIT:C82034 PMID:33620437 MIO:02349 quantification of the amount of prothrombin fragments F1+2 in a sample [url:http://www.ebi.ac.uk/efo/EFO_0007776] prothrombin fragments F1+2 F1 + 2 F1 + F2 PTF1_2 Prothrombin Fragments 1 + 2 Prothrombin Fragments 1 and 2 Prothrombin fragment 1+2 prothrombin fragments F1+2 NCIT:C122778 NCIT:C64491 PMID:29083808 UMLS:C0523584 MIO:02350 Creatinine kinase MB is also specific to the myocardium. It peaks at ten hours; however, it normalizes within two to three days.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] An isoenzyme complex comprised of a heterodimer of creatine kinase M-type and B-type. [url:http://purl.obolibrary.org/obo/NCIT_C122778] creatine kinase MB CK-MB CKMB CPK-MB Creatine Phosphokinase-MB creatine kinase MB creatine kinase-MB reatine Kinase-MB CMO:0000983 MIO:02351 The diameter across the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter. left ventricular end-systolic diameter LVESD heart left ventricle end-systolic diameter left ventricular end-systolic dimension MAXO:0000553 MIO:02352 Macrophages and T lymphocytes (T-cells) are the primary producers of cytokines which may have predominantly pro-inflammatory (inflammation-promoting)(IL-1alpha, IL-1beta, IL-2, IL-6, Il-8, IL-12, TNF-alpha, IFN-gamma) or anti-inflammatory (inflammation-suppressive)(IL-4, IL-5, IL-10, TGF-beta) abilities. Cytokines are small, nonstructural proteins, including interleukins, chemokines, interferons, and tumor necrosis factors, which have a multitude of pleiotropic effects in various organs [1]. They are released in a number of paracrine, autocrine, or endocrine pathways and have been implicated in a variety of infections and immune system-affecting disorders by both proinflammatory and anti-inflammatory mechanisms.[url:http://purl.obolibrary.org/obo/MAXO_0000553] cytokine biomarker NCIT:C77269 UMLS:C2697844 MIO:02353 A classification of myocardial infarction characterized by an absence of rales over the lung fields and an absence of S3. [url:http://purl.obolibrary.org/obo/NCIT_C77269] Killip class I Killip I Killip class 1 NCIT:C77270 UMLS:C2697845 MIO:02354 A classification of myocardial infarction characterized by rales over 50% or less of the lung fields or the presence of an S3. [url:http://purl.obolibrary.org/obo/NCIT_C77270] Killip class II Killip II Killip class 2 MIO:02355 Killip class II-III Killip class 2/3 MIO:02356 Killip class III-IV Killip class 3 or 4 Killip class 3/4 Killip class >/=3 Killip class >/=III Killip class >2 Killip class III or IV Killip class III to IV Killip class III/IV Killip classification >/= 3 SNOMED:250909007 MIO:02357 left ventricular wall motion LV wall motion LVWM NCIT:C38020 UMLS:C1335957 MIO:02358 The fraction of the left ventricle diastolic dimension that is lost during systole; the measurement is calculated using the following formula: (end-diastolic dimension - end-systolic dimension) / end-diastolic dimension; the quotient is then multiplied by one hundred to be expressed as a percent. [url:http://purl.obolibrary.org/obo/NCIT_C38020] left ventricular fractional shortening LVFS shortening fraction SNOMED:70822001 MIO:02359 cardiac ejection fraction ejection fraction CMO:0002873 MIO:02360 E' wave velocity is the peak velocity of early mitral annular diastolic motion. [url:http://purl.obolibrary.org/obo/CMO_0002873] E' wave velocity E' wave anterior mitral annular early diastolic velocity early diastolic mitral annulus velocity mitral annular early diastolic velocity NCIT:C139045 MIO:02361 The peak velocity of the annular motion during ventricular systole. [url:http://purl.obolibrary.org/obo/NCIT_C139045] annular S' velocity ANNSVEL early systolic mitral annular motion velocity longitudinal systolic velocity s' systolic velocity CMO:0002503 MIO:02362 Measurement of the speed at which blood flows into the ventricle during passive filling, that is, during the period when the blood flows from the atrium to the ventricle due to gravity rather than as a result of active contraction of the atrium. [url:http://purl.obolibrary.org/obo/CMO_0002503] E wave velocity E Em early diastolic filling velocity left ventricular peak early diastolic tissue velocity NCIT:C100073 MIO:02363 The use of physical activity to elicit signs and symptoms of myocardial ischemia. [url:http://purl.obolibrary.org/obo/NCIT_C100073] cardiac stress test cardiac test stress testing NCIT:C116517 MIO:02364 A clinical tool to evaluate exercise capacity and to assess cardiac function under stress. [url:http://purl.obolibrary.org/obo/NCIT_C116517] cardiopulmonary exercise testing CPET CPX NCIT:C38053 MIO:02365 A procedure that displays the electrical activity of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C38053] electrocardiography ECG EKG electrocardiogram electrocardiograms NCIT:C80408 UMLS:C2825165 MIO:02366 A study using radioisotope tagged blood components and a nuclear scanning machine to monitor the blood flow to the myocardium during or immediately following exercise. [url:http://purl.obolibrary.org/obo/NCIT_C80408] nuclear stress test OMIT:0025588 MIO:02367 magnetocardiography MCG magnetocardiographic mapping OMIT:0010235 MIO:02368 Myocardial contractility represents the innate ability of the heart muscle (cardiac muscle or myocardium) to contract. The ability to produce changes in force during contraction result from incremental degrees of binding between different types of tissue, that is, between filaments of myosin (thick) and actin (thin) tissue. The degree of binding depends upon the concentration of calcium ions in the cell. Within an in vivo intact heart, the action/response of the sympathetic nervous system is driven by precisely timed releases of a catecholamine, which is a process that determines the concentration of calcium ions in the cytosol of cardiac muscle cells. The factors causing an increase in contractility work by causing an increase in intracellular calcium ions (Ca++) during contraction. [url:https://en.wikipedia.org/wiki/Myocardial_contractility] myocardial contractility cardiac contractile function contractile function myocardial contractile myocardial contraction NCIT:C100071 MIO:02369 An imaging technique of the heart and neighboring structures involving helical computed tomography and computer software to generate high-resolution 2-dimensional and 3-dimensional images. [url:http://purl.obolibrary.org/obo/NCIT_C100071] cardiac computerized tomographic angiography computed tomographic coronary angiography coronary CT angiography NCIT:C100085 MIO:02370 The passage of a catheter into the aortic root or other great vessel for the purpose of angiography of the native coronary arteries or bypass grafts supplying native coronary arteries. [url:http://purl.obolibrary.org/obo/NCIT_C100085] coronary angiography coronary angiogram coronary arteriography NCIT:C16291 MIO:02371 A technique which subtracts two images that are obtained before and after contrast media is administered to the patient for the purpose of studying blood vessels. [url:http://purl.obolibrary.org/obo/NCIT_C16291] digital subtraction angiography digital subtraction coronary angiography SNOMED:443939006 MIO:02372 99mTc-tetrofosmin single photon emission computed tomography (99m)Tc-tetrofosmin SPECT 99mTc-tetrofosmin SPECT single photon emission computed tomography of myocardial perfusion using technetium 99m meta-iodobenzylguanidine tetrofosmin MIO:02373 99Tcm-pyrophosphate single photon emission computed tomography 99Tcm-PYP myocardial SPET imaging 99Tcm-pyrophosphate myocardial scintigraphy technetium-99m stannous pyrophosphate imaging NCIT:C46087 MIO:02374 A technique that uses radiofrequency waves and a magnet to image the body. The images are enhanced by the addition of contrast agents which selectively intensify anatomical regions to intensify the clarity of the image for diagnostic purposes. 2005 [url:http://purl.obolibrary.org/obo/NCIT_C46087] contrast-enhanced cardiac magnetic resonance imaging ceMRI MIO:02375 Gadolinium-based contrast agents are administered intravenously and delayed imaging is performed at least 10 minutes later to achieve optimum contrast between normal and infarcted myocardium. An inversion recovery (IR) sequence is used to null the signal from normal myocardium. Myocardial viability can be assessed by the degree of transmural enhancement. Cardiomyopathic, inflammatory and infiltrative diseases may also have distinctive patterns of non-ischemic LGE. [url:https://en.wikipedia.org/wiki/Cardiac_magnetic_resonance_imagingLate_gadolinium_enhancement] late gadolinium-enhanced cardiac magnetic resonance imaging LGE-CMR LGE-CMR imaging late gadolinium-enhanced cardiac magnetic resonance late-enhanced MRI NCIT:C38634 UMLS:C0013520 MIO:02376 A procedure that uses sound waves to measure characteristics of disturbed bood flow, such as direction, velocity and turbulence. This enables the examiner to differentiate between normal and abnormal flow patterns and, in some cases, to quantitate those characteristics that are helpful in determining the severity of abnormal flow states. [url:http://purl.obolibrary.org/obo/NCIT_C38634] doppler echocardiography doppler study NCIT:C80407 MIO:02377 An image of the heart produced by ultrasonography under conditions intended to elicit signs and symptoms of myocardial ischemia. Conditions often include exercise, pharmacologic agents or pacing. [url:http://purl.obolibrary.org/obo/NCIT_C80407] stress echocardiography stress echo OMIT:0019585 MIO:02378 Three-dimensional echocardiography (also known as four-dimensional echocardiography when the picture is moving) is now possible, using a matrix array ultrasound probe and an appropriate processing system. [url:https://en.wikipedia.org/wiki/EchocardiographyThree-dimensional_echocardiography] three-dimensional echocardiography 3-D echocardiography 3D echocardiography echocardiography, three-dimensional three-dimensional (3-D) echocardiography MIO:02379 Motion mode is infrequently used in modern echocardiography. It has specific uses and has the benefit of very high temporal fidelity (eg, measuring LV size at end diastole). [url:https://en.wikipedia.org/wiki/EchocardiographyM-mode] M-mode echocardiography SNOMED:433231002 MIO:02380 Contrast echocardiography or contrast-enhanced ultrasound is the addition of an ultrasound contrast medium, or imaging agent, to traditional ultrasonography. The ultrasound contrast is made up of tiny microbubbles filled with a gas core and protein shell. This allows the microbubbles to circulate through the cardiovascular system and return the ultrasound waves, creating a highly reflective image. There are multiple applications in which contrast-enhanced ultrasound can be useful. The most commonly used application is in the enhancement of LV endocardial borders for assessment of global and regional systolic function. Contrast may also be used to enhance visualization of wall thickening during stress echocardiography, for the assessment of LV thrombus, or for the assessment of other masses in the heart. Contrast echocardiography has also been used to assess blood perfusion throughout myocardium in the case of coronary artery disease. [url:https://en.wikipedia.org/wiki/EchocardiographyContrast_echocardiography] myocardial contrast echocardiography MCE contrast echocardiography contrast-enhanced ultrasound MIO:02381 In the fields of cardiology and medical imaging, speckle tracking echocardiography (STE) is an echocardiographic imaging technique. It analyzes the motion of tissues in the heart by using the naturally occurring speckle pattern in the myocardium (or motion of blood when imaged by ultrasound). [url:https://en.wikipedia.org/wiki/Speckle_tracking_echocardiography] speckle tracking echocardiography NCIT:C80405 MIO:02382 A cardiac ultrasound performed by passing a specialized probe containing a transducer into the patient's esophagus. [url:http://purl.obolibrary.org/obo/NCIT_C80405] transesophageal echocardiography TEE NCIT:C80404 UMLS:C0430462 MIO:02383 A non-invasive cardiac ultrasound performed by placing the transducer on the chest. [url:http://purl.obolibrary.org/obo/NCIT_C80404] transthoracic echocardiography TTE MIO:02384 Brightness mode is often synonymous with "2-D" and is very commonly used in echocardiography. [url:https://en.wikipedia.org/wiki/EchocardiographyB-mode_/_2D] two-dimensional echocardiography 2-D echocardiography 2-dimensional echocardiography 2D echocardiography B-mode echocardiography NCIT:C61044 UMLS:C1883480 MIO:02385 A quantitative measurement of a particular substance present in a sample of urine. [url:http://purl.obolibrary.org/obo/NCIT_C61044] urine chemistry measurement NCIT:C61014 MIO:02386 A quantitative measurement of a particular substance present in a sample of serum. [url:http://purl.obolibrary.org/obo/NCIT_C61014] serum chemistry measurement NCIT:C2315 NCIT:C74742 UMLS:C0441683 MIO:02387 One of many chemicals made by glands in the body. Hormones circulate in the bloodstream and control the actions of certain cells or organs. Some hormones can also be made in the laboratory. [url:http://purl.obolibrary.org/obo/NCIT_C2315] hormone Endocrine Gland Secretion hormones PMID:25271081 MIO:02388 SII is an inflammation-related indicator that integrates neutrophil, platelet, and lymphocyte counts and can reflect the comprehensive immune and inflammation situation in the body.[url:https://pubmed.ncbi.nlm.nih.gov/31849367/] The SII was defined as follows: SII = P × N/L, where P, N, and L were the preoperative peripheral platelet, neutrophil, and lymphocyte counts, respectively. [url:https://pubmed.ncbi.nlm.nih.gov/25271081/] systemic immune-inflammation index SII NCIT:C104683 NCIT:C81958 UMLS:C2825854 MIO:02389 Antithrombin (AT) is a small protein molecule that inactivates several enzymes of the coagulation system. Antithrombin is a glycoprotein produced by the liver and consists of 432 amino acids. It contains three disulfide bonds and a total of four possible glycosylation sites. α-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites. A single glycosylation site remains consistently un-occupied in the minor form of antithrombin, β-antithrombin. [url:https://en.wikipedia.org/wiki/Antithrombin] antithrombin-III ANTHRMA antithrombin antithrombin III activity antithrombin activity NCIT:C62656 UMLS:C0033707 MIO:02390 A measurement of the clotting time of plasma recalcified in the presence of excess tissue thromboplastin; it is a measure of the extrinsic pathway of coagulation. It is used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage and vitamin K status. Factors measured are fibrinogen, prothrombin, and factors V, VII, and X. [url:http://purl.obolibrary.org/obo/NCIT_C62656] prothrombin time PT prothrombin time test NCIT:C114300 MIO:02391 Tobacco smokers have a higher physiologic percentage of COHb than non-smokers.[url:http://purl.obolibrary.org/obo/NCIT_C114300] Hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO). This complex is produced after CO has been inhaled or as a byproduct of hemoglobin, protoporphyrin or dichloromethane catabolism. The heme-CO complex is approximately 200 times more stable than heme-oxygen complexes. Thus, high levels of carboxyhemoglobin in the circulation can lead to tissue hypoxia and death. [url:http://purl.obolibrary.org/obo/NCIT_C114300] carboxyhemoglobin COHb NCIT:C64849 MIO:02392 Glycated hemoglobin (glycohemoglobin, hemoglobin A1c, HbA1c, less commonly HbA1c, HgbA1c, Hb1c, etc., also A1C informally with patients) is a form of hemoglobin (Hb) that is chemically linked to a sugar. Most monosaccharides, including glucose, galactose and fructose, spontaneously (i.e. non-enzymatically) bond with hemoglobin, when present in the bloodstream of humans. However, glucose is less likely to do so than galactose and fructose (13% that of fructose and 21% that of galactose), which may explain why glucose is used as the primary metabolic fuel in humans. [url:https://en.wikipedia.org/wiki/Glycated_hemoglobin] glycated hemoglobin A1C HBA1C HGBA1C Hb1c glycosylated hemoglobin A1C hemoglobin A1C PMID:11583872 MIO:02393 The measurement of monocyte-platelet aggregates (MPA) may be a more robust signal of platelet activation than the detection of surface P-selectin on individual platelets because degranulated platelets rapidly lose surface P-selectin in vivo yet continue to circulate.[PMID:11583872] monocyte-platelet aggregates MPA NCIT:C48966 MIO:02394 An antibody acting against tissues of the organism that produces it. [url:http://purl.obolibrary.org/obo/NCIT_C48966] autoantibody MIO:02395 Any of the structurally related glycoproteins that function as antibodies. They are divided into five classes (IGA, IGD, IGE, IGG, IGM) on the basis of structure and biological activity. [url:http://purl.obolibrary.org/obo/NCIT_C572] immunoglobulin Ig immune globulin immunoglobulins immunoglobulins / antibodies SNOMED:115256001 MIO:02396 protein antigen NCIT:C21527 MIO:02397 Complement C3 (1663 aa, ~187 kDa) is encoded by the human C3 gene. This protein plays a role in complement-mediated immunity. The component of the early complement cascade common to all three activation pathways. C3 is consumed by proteolysis upon activation. C3 levels are generally low when immune complex mediated diseases are active, such as systemic lupus erythematosus or post-streptococcal glomerulonephritis. [url:http://purl.obolibrary.org/obo/NCIT_C21527] complement C3 C3 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 complement component 3 NCIT:C70618 NCIT:C80177 UMLS:C0577608 MIO:02398 An early component of the classical and mannose binding lectin (MBL) complement activation pathways. C4 is consumed by proteolysis upon activation of the classical and MBL pathways, but not the alternative pathway. C4 levels are generally low in active immune complex diseases mediated by classical or MBL activation, but not alternative activation, with the canonical example being systemic lupus erythematosus. [url:http://purl.obolibrary.org/obo/NCIT_C70618] complement C4 C4 Complement Component-4 NCIT:C70611 MIO:02399 Complement C5 (1676 aa, ~188 kDa) is encoded by the human C5 gene. This protein is involved in complement-mediated immunity. [url:http://purl.obolibrary.org/obo/NCIT_C21539] complement C5 C3 and PZP-Like Alpha-2-macroglobulin domain-containing protein 4 C5 CH50 Prepro-C5 complement component 5 hemolytic complement NCIT:C105381 MIO:02400 Complement C1q subcomponent subunit A (245 aa, ~26 kDa) is encoded by the human C1QA gene. This protein plays a role in the activation of the classical complement pathway. [url:http://purl.obolibrary.org/obo/NCIT_C105381] complement C1q subcomponent subunit A c1qa complement c1q subcomponent subunit a complement component 1, q subcomponent, a chain complement component 1, q subcomponent, alpha polypeptide complement component c1q, a chain PMO:00086154 MIO:02401 long non-coding RNA gene lncRNA gene NCIT:C80699 MIO:02402 A gene that encodes a microRNA, which participates in the regulation of gene expression. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80699] microRNA gene miRNA gene micro RNA gene SIO:001228 MIO:02403 A small nuclear RNA (snRNA) gene is a gene that encodes a small niuclear RNA molecule. [url:http://semanticscience.org/resource/SIO_001228] small nuclear RNA gene small nuclear RNA (snRNA) gene snRNA gene GSSO:010091 MIO:02404 Variation in chromosome structure including microscopic and submicroscopic types of variation such as deletions, duplications, copy-number variants, insertions, inversions and translocations. [url:http://purl.obolibrary.org/obo/GSSO_010091] chromosome structure variation chromosome structure variations MIO:02405 The ratio between the levels of calcium and magnesium. calcium to magnesium ratio MIO:02406 The ratio between the levels of potassium and magnesium. potassium/magnesium ratio MIO:02407 The ratio between the levels of sodium and potassium. sodium/potassium ratio MIO:02408 The ratio between the levels of estradiol and testosterone. estradiol to testosterone ratio PMID:20671231 MIO:02409 a thiol originating from GGT-mediated cleavage of glutathione [PMID:20671231] cysteinyl-glycine MIO:02410 The ratio between the levels of disulphide and total thiol. disulphide/total thiol ratio NCIT:C74787 MIO:02411 free triiodothyronine T3FR free T3 NCIT:C81968 MIO:02412 reverse triiodothyronine RT3 reverse T3 UPa:UPC00366 MIO:02413 a salt of uric acid urate NCIT:C92268 SNOMED:707053000 MIO:02414 25-hydroxyvitamin D 25(OH)D PMID:31554413 MIO:02415 The acute-to-chronic glycemic ratio was expressed as admission blood glucose (ABG) devided by the estimated average glucose (eAG), and eAG was derived from the glycated hemoglobin (HbA1c). [url:https://pubmed.ncbi.nlm.nih.gov/31554413/] acute-to-chronic glycemic ratio ABG/eAG NCIT:C80400 MIO:02416 A quantitative measurement of the amount of glucose present in a sample of blood, obtained from a source that has abstained from nutrition, typically at least 8 hours prior to the sample collection time. [url:http://purl.obolibrary.org/obo/NCIT_C80400] fasting blood glucose FBG FBS fasting blood glucose level fasting blood glucose measurement fasting blood sugar fasting blood sugar measurement fasting glucose fasting glucose level fasting glucose-related traits fasting plasma glucose EFO:0004307 MIO:02417 A test to determine the ability of an individual to maintain homeostatis of blood glucose. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg). [url:http://www.ebi.ac.uk/efo/EFO_0004307] glucose tolerance test glucose tolerance PMID:31722708 MIO:02418 The triglyceride-glucose index (TyG index), the product of fasting plasma glucose (FPG) and triglycerides (TGs), has been used in clinical practice as a simple and reliable surrogate marker of insulin resistance (IR).[PMID:31722708] triglyceride-glucose index MMO:0000115 SNOMED:271061004 MIO:02419 Measures blood glucose level one or more times a day regardless of food intake. [url:http://purl.obolibrary.org/obo/MMO_0000115] random blood glucose RBG random blood glucose measurement random blood glucose test MIO:02420 random plasma glucose plasma random glucose plasma random glucose level NCIT:C74753 MIO:02421 The determination of the ratio of blood urea nitrogen compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage. [url:http://purl.obolibrary.org/obo/NCIT_C74753] blood urea nitrogen to creatinine ratio MIO:02422 The ratio between the levels of homocysteine thiolactone and creatinine. homocysteine thiolactone/creatinine ratio NCIT:C492 MIO:02423 Monobasic, aliphatic acids with varying chain lengths between 6 and 30. Fatty acids are a major constituent in all fats and can be either saturated, monounsaturated, or polyunsaturated. Saturated and monounsaturated fatty acids are synthesized by the body, whereas polyunsaturated fatty acids are not and must be obtained in the diet. [url:http://purl.obolibrary.org/obo/NCIT_C492] fatty acid fatty acids EFO:0003836 MIO:02424 Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes. [url:http://www.ebi.ac.uk/efo/EFO_0003836] lipoprotein circulating lipoproteins lipoproteins NCIT:C105586 SNOMED:121868005 MIO:02425 The determination of the amount of total cholesterol present in a sample. [url:http://purl.obolibrary.org/obo/NCIT_C105586] total cholesterol TC cholesterol NCIT:C64812 NCIT:C906 MIO:02426 Fats composed of three fatty acid chains linked to a glycerol molecule. [url:http://purl.obolibrary.org/obo/NCIT_C906] triglyceride TAG TG triacylglyceride triacylglycerol triglycerides NCIT:C80171 MIO:02427 The determination of the ratio of total cholesterol compared to high-density lipoprotein type cholesterol present in a sample. The measurement may be expressed as a ratio or percentage. [url:http://purl.obolibrary.org/obo/NCIT_C80171] total cholesterol to high-density lipoprotein cholesterol ratio cholesterol to HDL-cholesterol ratio cholesterol/HDL-cholesterol ratio of total cholesterol/HDL cholesterol NCIT:C37937 MIO:02428 An endogenous amino acid derivative produced by vertebrate animals and occurring primarily in muscle cells. Creatine is important for energy storage; it is phosphorylated to creatine phosphate, which serves as a phosphate donor in the conversion of ADP to ATP and supplies energy necessary for muscle contraction. Dietary supplementation with creatine may improve muscle wasting associated with cancer and other chronic diseases. [url:http://purl.obolibrary.org/obo/NCIT_C37937] creatine glycine, N-(aminoiminomethyl)-N-methyl- NCIT:C105949 NCIT:C74741 MIO:02429 An amino acid derivative and homolog of cysteine containing an additional methylene bridge. Homocysteine is a product of methionine metabolism and elevated plasma levels are associated with cardiovascular disease, Alzheimer disease and several metabolic diseases. [url:http://purl.obolibrary.org/obo/NCIT_C105949] homocysteine 2-Amino-4-Mercapto-Butyric acid 2-Amino-4-Mercaptobutyric Acid 2-Amino-4-Sulfanylbutanoic Acid Butanoic Acid, 2-Amino-4-Mercapto- HOMOC Hcy Homo-Cys homocysteine acid NCIT:C103150 MIO:02430 A specific biomarker of hypochlorous acid (HClO), the oxidation product of myeloperoxidase (MPO). Under oxidative stress, 3-chlorotyrosine is produced in proteins with tyrosine residues by the strong oxidant HClO. HClO which is formed at sites of inflammation is also the anti-bacterial molecule produced by neutrophils through MPO-catalyzed oxidation. MPO is a heme-containing enzyme secreted by activated neutrophils and monocytes; it is the only enzyme that produces HClO. Therefore, 3-chlorotyrosine can potentially be used to help determine the extent of neutrophilic inflammation. [url:http://purl.obolibrary.org/obo/NCIT_C103150] 3-chlorotyrosine 3-Chloro-L-Tyrosine Cl-Tyr L-(8CI)-3-Chloro-Tyrosine chlorotyrosine monochlorotyrosine CHEBI:74049 MIO:02431 An L-tryptophan derivative that is L-tryptophan with a methoxy substituent at position 5.[url:http://purl.obolibrary.org/obo/CHEBI_74049] 5-methoxytryptophan 5-methoxy-L-tryptophan NCIT:C124264 MIO:02432 A methylated derivative of L-arginine that is a competitive inhibitor of nitric oxide synthase (NOS). Asymmetric dimethylarginine (ADMA) is formed when S-adenosylmethionine protein N-methyltransferases transfer methyl groups from S-adenosylmethionine to arginine. Free ADMA in plasma competes with the L-arginine for binding to the heme in NOS and inhibits nitric oxide (NO) synthesis. Decreased synthesis of NO inhibits vasodilation and leads to endothelial dysfunction. Elevated plasma levels of ADMA are seen in certain types of cancer, cardiovascular disease, hypertension, hyperlipidemia, type 2 diabetes mellitus, and increased oxidative stress. [url:http://purl.obolibrary.org/obo/NCIT_C124264] asymmetric dimethylarginine ADMA Guanidino-N(1),N(1)-Dimethylarginine Guanidino-N,N-Dimethylarginine N(G),N(G)-Dimethylarginine N(G1),N(G1)-Dimethylarginine N,N-DIMETHYLARGININE NCIT:C82599 MIO:02433 An amino acid derivative. Carnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain. [url:http://purl.obolibrary.org/obo/NCIT_C82599] carnitine (3-Carboxy-2-hydroxypropyl)trimethylammonium Hydroxide Inner Salt NCIT:C118875 MIO:02434 An amino acid derivative that is an intermediate in the biosynthesis of cysteine. It is the product of the ligation of homocysteine and serine by cystathionine beta synthase. [url:http://purl.obolibrary.org/obo/NCIT_C118875] cystathionine 2-Amino-4-(2-Amino-2-Carboxy-Ethyl) Thio-Butanoic Acid 2-Amino-4-[(2-Amino-2-Carboxyethyl)Sulfanyl]Butanoic Acid DL-Allocystathionine DL-Cystathionine Homocysteine, S-(2-Amino-2-Carboxyethyl)- S-(2-Amino-2-Carboxyethyl)Homocysteine XLMOD:09003 MIO:02435 Dimethylglycine (DMG) is a derivative of the amino acid glycine with the structural formula (CH3)2NCH2COOH. It can be found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline. [url:https://en.wikipedia.org/wiki/Dimethylglycine] dimethylglycine DMG N,N-Dimethylglycine NCIT:C120013 MIO:02436 A lysine derivative found in proteins where the epsilon nitrogen of the amino acid residue is modified by a carboxymethyl group. This advanced glycation end product (AGE) is elevated in certain diseases and is associated with aging. [url:http://purl.obolibrary.org/obo/NCIT_C120013] N(6)-carboxymethyllysine CML L-Lysine, N6-(Carboxymethyl)- N(6)-Carboxymethyllysine N(Epsilon)-(Carboxymethyl)Lysine N(Epsilon)-Carboxymethyl-L-Lysine NECML SNOMED:259547003 MIO:02437 free L-carnitine MIO:02438 Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this protein is encoded by the AGRN gene.[url:https://en.wikipedia.org/wiki/Agrin] C-terminal fragment of agrin EFO:0010934 MIO:02439 The ratio between the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). [url:http://www.ebi.ac.uk/efo/EFO_0010934] aspartate aminotransferase to alanine aminotransferase ratio AST:ALT ratio De-Ritis ratio NCIT:C74761 MIO:02440 A relative measurement (ratio) of the albumin to the creatinine in a biological specimen. [url:http://purl.obolibrary.org/obo/NCIT_C74761] albumin to creatinine protein ratio ACR ALBCREAT Albumin/Creatinine Microalbumin/Creatinine Ratio albumin to creatinine ratio albumin-to-creatinine ratio albumin/creatinine ratio urine albumin to creatinine ratio MIO:02441 The determination of the ratio of albumin compared to globulin in a blood sample. The measurement may be expressed as a ratio or percentage. [url:http://purl.obolibrary.org/obo/NCIT_C74894] albumin to globulin ratio ALBGLOB albumin-globulin ratio albumin/globulin MIO:02442 The ratio between the levels of C-reactive protein and albumin. C-reactive protein/albumin ratio NCIT:C174434 MIO:02443 The determination of the ratio of fibrinogen to albumin in a biological sample. The measurement may be expressed as a ratio or percentage. [url:http://purl.obolibrary.org/obo/NCIT_C174434] fibrinogen to albumin ratio FAR fibrinogen-to-albumin ratio fibrinogen/albumin ratio PMID:20362714 MIO:02444 Ischemia-modified albumin is a sensitive marker of ischemia, which interferes with the binding of albumin to cobalt, and occurs before the development of myocardial necrosis and its detection by biomarkers such as troponin. [PMID:20362714] ischemia-modified albumin PR:P0DUB6 MIO:02445 A protein that is a translation product of the AMY1A gene in human. [url:http://purl.obolibrary.org/obo/PR_P0DUB6] alpha-amylase 1A 1,4-alpha-D-glucan glucanohydrolase 1A AMY1 AMY1A hAMY1A salivary alpha-amylase NCIT:C95408 UMLS:C0162596 MIO:02446 An autoantibody that reacts with cardiolipin. Different immunoglobulin subclasses and isotypes are associated with different diseases and conditions. Some anticardiolipin antibodies prolong phospholipid dependent clotting while others are associated with spontaneous abortion. [url:http://purl.obolibrary.org/obo/NCIT_C95408] anticardiolipin antibody ACA ACL ACLA anticardiolipin antibodies NCIT:C103356 MIO:02447 The determination of the ratio of the Apolipoprotein B compared with Apolipoprotein A1 in a sample. The measurement may be expressed as a ratio or percentage. [url:http://purl.obolibrary.org/obo/NCIT_C103356] apolipoprotein B to apolipoprotein A1 ratio APOBAPA1 apoB/apoA-I apoB/apoA-I ratio apolipoprotein B/apolipoprotein A-I apolipoprotein B/apolipoprotein A1 PMID:29083808 MIO:02448 High-sensitivity troponin has recently been approved for use in the United States after having been heavily studied and utilized in Europe. Although it is more sensitive than conventional troponin, it is also less specific. Thus, potential challenges include numerous false-positive interpretations.[url:https://pubmed.ncbi.nlm.nih.gov/29083808/] high sensitivity cardiac troponin high sensitivity troponin high-sensitivity cardiac troponin high-sensitivity troponin hs-cTn NCIT:C104226 MIO:02449 Troponin I, cardiac muscle (210 aa, ~24 kDa) is encoded by the human TNNI3 gene. This protein is involved in muscle filament movement in cardiac cells. [url:http://purl.obolibrary.org/obo/NCIT_C104226] troponin I, cardiac muscle TROPONI cTnI cardiac troponin I troponin I NCIT:C104220 MIO:02450 Troponin T, cardiac muscle (298 aa, ~36 kDa) is encoded by the human TNNT2 gene. This protein plays a role in cardiac muscle contraction. [url:http://purl.obolibrary.org/obo/NCIT_C104220] troponin T, cardiac muscle TNNT TROPONT cTnt cardiac muscle troponin T cardiac troponin T troponin T MIO:02451 The ratio between the levels of CD40 ligand and interleukin-10. CD40 ligand/interleukin-10 ratio NCIT:C157114 MIO:02452 The determination of the amount of C-reactive protein (CRP) present in a sample through the use of immunonephelometry, immunoturbidimetry, high-sensitivity enzyme-linked immunosorbent assay (ELISA) and/or resonant acoustic profiling (RAP). This test is optimized to measure lower concentrations of CRP than a conventional CRP test. [url:http://purl.obolibrary.org/obo/NCIT_C157114] high sensitivity C-reactive protein high sensitivity CRP high-sensitivity C-reactive protein hs-CRP hsCRP NCIT:C153549 MIO:02453 The determination of the amount of C-reactive protein (CRP) present in a sample, usually serum from a blood draw from a subject that does not have a chronic inflammatory condition, through the use of an enhanced particle-enhanced immunoturbidimetric assay. This test is optimized to measure lower concentrations of CRP than a conventional CRP test. Accuracy is enhanced to ultra high levels through the use of a proprietary set of calibrated CRP samples. [url:http://purl.obolibrary.org/obo/NCIT_C153549] ultra high sensitivity C-reactive protein uhs-CRP uhsCRP ultra high sensitivity CRP PR:000005515 MIO:02454 A creatine kinase that is a translation product of the human CKM gene or a 1:1 ortholog thereof. [url:http://purl.obolibrary.org/obo/PR_000005515] creatine kinase M-type CKM CPK-M M-CK MM-CK creatine kinase M chain creatine kinase, muscle creatine phosphokinase M-type MIO:02455 C-terminal pro-endothelin-1 C-terminal-pro-endothelin-1 CT-proET-1 OMIT:0006556 PMID:33620437 PR:P02675 MIO:02456 Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. [url:https://www.uniprot.org/uniprot/P02675] fibrinogen beta chain FGB FPB fibrinopeptide B OMIT:0006555 PMID:33620437 PR:P02671 MIO:02457 Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. [url:https://www.uniprot.org/uniprot/P02671] fibrinogen alpha chain FPA fibrinopeptide A PR:P02679 MIO:02458 A fibrinogen gamma chain that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P02679] fibrinogen gamma chain FGG PRO2061 hFGG PR:P19440 MIO:02459 A glutathione hydrolase 1 proenzyme that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_P19440] glutathione hydrolase 1 proenzyme CD224 GGT GGT 1 GGT1 gamma-glutamyltransferase 1 gamma-glutamyltranspeptidase 1 hGGT1 leukotriene-C4 hydrolase EFO:0004572 MIO:02460 A C4BP measurement is the quantification of C4BP, it controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. (Uniprot defintion). Buil et al, 2010 propose that C4BP may be a susceptibility locus for venous thrombosis based on GWAS and gene expression studies. [url:http://www.ebi.ac.uk/efo/EFO_0004572] C4b binding protein C4BP C4b-binding protein NCIT:C88169 MIO:02461 Histidine-rich glycoprotein (525 aa, ~60 kDa) is encoded by the human HRG gene. This protein may be involved in both ion binding and thrombosis. [url:http://purl.obolibrary.org/obo/NCIT_C88169] histidine-rich glycoprotein HPRG Histidine-Proline Rich Glycoprotein Histidine-Proline-Rich Glycoprotein NCIT:C147308 MIO:02462 beta-2 glycoprotein 1 IgA antibody B2G1GAAB anti-beta2-gpI IgA antibodies anti-beta2GPI IgA PMID:15978102 MIO:02463 IgA antibody to endothelial protein C receptor IgA anti-EPCR IgA antibodies to endothelial protein C receptor SNOMED:404273000 MIO:02464 allergen specific immunoglobulin E allergen specific IgE specific immunoglobulin E PMID:20176799 MIO:02465 anti-apolipoprotein A-1 IgG IgG anti-apolipoprotein A-1 antibodies IgG anti-apolipoprotein A-1 antibody anti-apoA-1 IgG antiapolipoprotein A-1 IgG NCIT:C70990 MIO:02466 An IgG autoantibody directed against cardiolipin. It is associated with thrombosis, spontaneous abortion, and complications during labor. [url:http://purl.obolibrary.org/obo/NCIT_C70990] anticardiolipin IgG antibody ACA IgG aCL IgG anticardiolipin antibody (aCL) IgG NCIT:C103358 MIO:02467 beta-2 glycoprotein 1 IgG antibody APOH IgG antibody B2G1GGAB anti-beta2GPI IgG antibodies apolipoprotein H IgG antibody PMID:7979858 MIO:02468 IgG antibody to oxidized low-density lipoprotein immunoglobulin G class antibodies against oxidized low-density lipoprotein oxidized low-density lipoprotein IgG PR:000001471 MIO:02469 A class 2 cytokine, IL-10 type that is a translation product of the human IL10 gene or a 1:1 ortholog thereof. Active interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulfide bond [url:http://purl.obolibrary.org/obo/PR_000001471] interleukin-10 CSIF CSIF-10 IL-10 IL10 IL10A T-cell growth inhibitory factor TGIF cytokine synthesis inhibitory factor interleukin 10 interleukin 10 precursor NCIT:C101779 MIO:02470 Interleukin-33 (270 aa, ~31 kDa) is encoded by the human IL33 gene. This protein plays a role in the positive regulation of inflammation. [url:http://purl.obolibrary.org/obo/NCIT_C101779] interleukin-33 il-1f11 il-33 il33 interleukin-1 family member 11 interleukin-33 nf-hev nuclear factor from high endothelial venules NCIT:C20451 MIO:02471 Interleukin-6 (212 aa, ~24 kDa) is encoded by the human IL6 gene. This protein is involved in signaling affecting a wide variety of cell types including monocytes, lymphocytes, hepatocytes and nerve cells. One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-6 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and also causes fever by affecting areas of the brain that control body temperature. Interleukin-6 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-6 is a type of cytokine. Also called IL-6. [url:http://purl.obolibrary.org/obo/NCIT_C20451] interleukin-6 B cell differentiation factor 2 B-cell differentiation factor B-cell stimulatory factor-2 BSF-2 BSF2 CDF CTL differentiation factor HGF HPGF HSF IFN beta 2 IFN-beta-2 IFNB2 IL-6 IL6 INTLK6 hepatocyte stimulating factor hepatocyte stimulatory factor hybridoma growth factor interferon beta-2 interleukin 6 interleukin BSF-2 myeloid differentiation inducing protein plasmacytoma growth factor sigosix NCIT:C20514 MIO:02472 Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI) [url:http://purl.obolibrary.org/obo/NCIT_C20514] interleukin-12 clmf cytotoxic lymphocyte maturation factor il-12 il-12 p70 il-12p70 il12 interleukin 12 interleukin-12 natural killer cell stimulatory factor nksf NCIT:C20515 MIO:02473 Interleukin-13 (146 aa, ~16 kDa) is encoded by the human IL13 gene. This protein plays a role in the negative regulation of cytokine production and the positive regulation of B-cell proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C20515] interleukin-13 il-13 il13 interleukin 13 interleukin-13 NCIT:C20519 MIO:02474 Interleukin-17A (155 aa, ~18 kDa) is encoded by the human IL17A gene. This protein is involved in the positive regulation of cytokine production. [url:http://purl.obolibrary.org/obo/NCIT_C20519] interleukin-17A ctla-8 ctla8 cytotoxic t-lymphocyte-associated antigen 8 cytotoxic t-lymphocyte-associated serine esterase 8 il-17 il-17a il17 il17 protein il17a interleukin 17 interleukin 17 precursor interleukin-17 interleukin-17a NCIT:C20520 NCIT:C74814 MIO:02475 Interleukin-18 (193 aa, ~22 kDa) is encoded by the human IL18 gene. This protein is involved in the regulation of both natural killer cell activity and the production of interferon gamma. [url:http://purl.obolibrary.org/obo/NCIT_C20520] interleukin-18 IFN-gamma-inducing factor IGIF IL-1 gamma IL-18 IL-1g IL18 IL18 protein IL1F4 INTLK18 interferon gamma-inducing factor interferon-gamma inducing factor interferon-gamma-inducing factor interleukin 18 interleukin 18 proprotein interleukin-1 gamma interleukin-18 precursor NCIT:C28613 NCIT:C74815 MIO:02476 Interleukin-19 (177 aa, ~20 kDa) is encoded by the human IL19 gene. This protein plays a role in the positive regulation of apoptosis. [url:http://purl.obolibrary.org/obo/NCIT_C28613] interleukin-19 IL-10C IL-19 IL19 IL19 protein MDA1 ZMDA1 interleukin 19 interleukin 19 precursor interleukin-19 precursor melanoma differentiation associated protein-like protein melanoma differentiation-associated protein-like protein NCIT:C20522 MIO:02477 Interleukin-1 beta (269 aa, ~31 kDa) is encoded by the human IL1B gene. This protein is involved in the macrophage-dependent inflammatory response. [url:http://purl.obolibrary.org/obo/NCIT_C20522] interleukin-1 beta catabolin il-1 beta il-1-b il-1-beta il-1b il1-beta il1b il1b protein il1f2 interleukin 1, beta interleukin 1, beta proprotein interleukin 1-beta interleukin-1 beta interleukin-1-beta preinterleukin 1 beta NCIT:C104346 MIO:02478 Interleukin-21 (155 aa, ~18 kDa) is encoded by the human IL21 gene. This protein plays a role in both receptor-mediated signaling and the inflammatory response. [url:http://purl.obolibrary.org/obo/NCIT_C104346] interleukin-21 il-21 il21 interleukin-21 za11 NCIT:C117087 MIO:02479 Interleukin-27 subunit alpha (243 aa, ~27 kDa) is encoded by the human IL27 gene. This protein is involved in the modulation of angiogenesis, inflammation and tumorigenesis. [url:http://purl.obolibrary.org/obo/NCIT_C117087] interleukin-27 subunit alpha il-27 p28 subunit il-27 subunit alpha il-27-a il27 il27-a il27a interleukin 27, 28-kd subunit interleukin-27 subunit alpha interleukin-30 p28 NCIT:C127926 MIO:02480 Interleukin-32 (234 aa, ~27 kDa) is encoded by the human IL32 gene. This protein is involved in interleukin-dependent signaling. [url:http://purl.obolibrary.org/obo/NCIT_C127926] interleukin-32 il-32 il32 interleukin 32 interleukin-32 natural killer cells protein 4 tumor necrosis factor alpha-inducing factor NCIT:C122069 MIO:02481 Interleukin-34 (242 aa, ~27 kDa) is encoded by the human IL34 gene. This protein plays a role in binding to macrophage colony-stimulating factor 1 receptor and the induction of receptor signaling. [url:http://purl.obolibrary.org/obo/NCIT_C122069] interleukin-34 il-34 il34 interleukin 34 interleukin-34 PR:Q9NZH6 MIO:02482 An interleukin-1 family member 7 that is encoded in the genome of human.|Category=organism-gene. [url:http://purl.obolibrary.org/obo/PR_Q9NZH6] interleukin-37 FIL1 zeta FIL1Z IL-1 zeta IL-1F7 IL-1H IL-1H4 IL-1RP1 IL-1X IL-37 IL1F7 IL1H4 IL1RP1 IL37 hIL37 interleukin-1 family member 7 interleukin-1 homolog 4 interleukin-1 zeta interleukin-1-related protein interleukin-23 NCIT:C20508 MIO:02483 Interleukin-4 (153 aa, ~17 kDa) is encoded by the human IL4 gene. This protein is involved in the regulation of the expression of class II MHC molecules, Fc receptors and cell surface-bound immunoglobulins. [url:http://purl.obolibrary.org/obo/NCIT_C20508] interleukin-4 b cell proliferating factor b-cell differentiation factor-1 b-cell growth factor b-cell growth factor-1 b-cell stimulating factor b-cell stimulation factor-1 b-cell stimulatory factor 1 bcdf-1 bcgf bcgf-1 bcsf 1 bsf-1 bsf1 il-4 il4 il4 protein interleukin 4 interleukin-4 interleukin-4 precursor lymphocyte stimulatory factor 1 mast cell growth factor-2 mcgf 2 NCIT:C20510 MIO:02484 Interleukin-7 (177 aa, ~20 kDa) is encoded by the human IL7 gene. This protein plays a role in lymphocyte proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C20510] interleukin-7 il-7 il7 il7 protein interleukin 7 precursor interleukin-7 lymphopoietin-1 NCIT:C20473 NCIT:C74836 MIO:02485 Interleukin-8 (99 aa, ~11 kDa) is encoded by the human CXCL8 gene. This protein is involved in chemotaxis and neutrophil activation. [url:http://purl.obolibrary.org/obo/NCIT_C20473] interleukin-8 C-X-C motif chemokine 8 CXCL8 GCP-1 GCP-IL-8 IL-8 IL8 INTLK8 MDNCF MONAP NAP-1 T-cell chemotactic factor alveolar macrophage chemotactic factor I anionic neutrophil activating peptide anionic neutrophil-activating peptide beta endothelial cell-derived neutrophil activating peptide beta-thromboglobulin-like protein granulocyte chemotactic peptide interleukin 8 granulocyte chemotactic protein 1 interleukin 8 interleukin-8 leukocyte adhesion inhibitor lung giant cell carcinoma-derived chemotactic protein lymphocyte derived neutrophil activating peptide macrophage-derived chemotactic factor monocyte-derived neutrophil chemotactic factor monocyte-derived neutrophil-activating peptide neutrophil activation factor neutrophil activation peptide neutrophil chemotactic factor neutrophil-activating peptide 1 neutrophil-activating protein 1 protein 3-10C NCIT:C104193 MIO:02486 A protein complex that is comprised of a homotetramer of the L-lactate dehydrogenase A chain which is encoded by the human LDHA gene. This enzyme complex is involved in the last step of anaerobic glycolysis and is expressed in the liver and in skeletal muscle. [url:http://purl.obolibrary.org/obo/NCIT_C104193] lactate dehydrogenase isoenzyme 5 HLDH5 LD-5 LDH isoenzyme 5 LDH-5 lactate dehydrogenase isoenzyme-5 lactic dehydrogenase isoenzyme 5 PMID:22963984 MIO:02487 malondialdehyde low density lipoprotein MDA-LDL malondialdehyde-LDL NCIT:C17592 NCIT:C80193 MIO:02488 72 kDa type IV collagenase (660 aa, ~74 kDa) is encoded by the human MMP2 gene. This protein is involved in both proteolysis and angiogenesis. [url:http://purl.obolibrary.org/obo/NCIT_C17592] 72 kDa type IV collagenase 3/4 collagenase, matrix metalloproteinase 5 72 kDa gelatinase type A 72 kda gelatinase 72 kda type iv collagenase 72-kDa gelatinase 72kda gelatinase 72kda type iv collagenase MMP 2 MMP-2 MMP2 collagenase IV collagenase type IV gelatinase A matrix metalloprotease 2 matrix metalloprotease-2 matrix metalloproteinase 2 matrix metalloproteinase-2 tbe-1 type IV collagen metalloproteinase type IV collagenase type IV collagenase/gelatinase NCIT:C102923 MIO:02489 Collagenase 3 (471 aa, ~54 kDa) is encoded by the human MMP13 gene. This protein plays a role in the proteolysis of the extracellular matrix. [url:http://purl.obolibrary.org/obo/NCIT_C102923] collagenase 3 collagenase 3 collagenase-3 ec 3.4.24.- matrix metalloprotease 13 matrix metalloprotease-13 matrix metalloproteinase 13 matrix metalloproteinase-13 mmp-13 mmp13 NCIT:C41044 PR:P03956 MIO:02490 Interstitial collagenase (469 aa, ~54 kDa) is encoded by the human MMP1 gene. This protein plays a role in collagenolysis. [url:http://purl.obolibrary.org/obo/NCIT_C41044] interstitial collagenase CLG EC 3.4.24.7 MMP-1 MMP1 fibroblast collagenase matrix metalloprotease 1 matrix metalloprotease-1 matrix metalloproteinase 1 matrix metalloproteinase-1 NCIT:C17575 NCIT:C80197 MIO:02491 Matrix metalloproteinase-9 (707 aa, ~78 kDa) is encoded by the human MMP9 gene. This protein plays a role in collagen degradation, macrophage differentiation and cell migration. [url:http://purl.obolibrary.org/obo/NCIT_C17575] matrix metalloproteinase-9 92 kDa Gelatinase 92 kDa type IV collagenase EC 3.4.24.35 GELB MMP-9 MMP9 gelatinase B macrophage gelatinase matrix metalloproteinase 9 type V collagenase NCIT:C41046 PR:000010490 MIO:02492 Neutrophil collagenase (467 aa, ~53 kDa) is encoded by the human MMP8 gene. This protein plays a role in the proteolysis of fibrillar collagen. [url:http://purl.obolibrary.org/obo/NCIT_C41046] neutrophil collagenase CLG1 EC 3.4.24.34 HNC MMP-8 MMP8 PMNL collagenase PMNL-CL collagenase 2 human collagenase 2 matrix metalloprotease 8 matrix metalloprotease-8 matrix metalloproteinase 8 matrix metalloproteinase-8 NCIT:C17571 NCIT:C80194 MIO:02493 Stromelysin-1 (477 aa, ~54 kDa) is encoded by the human MMP3 gene. This protein is involved in cleavage of fibronectin, laminin and proteoglycans. [url:http://purl.obolibrary.org/obo/NCIT_C17571] stromelysin-1 EC 3.4.24.17 MMP-3 MMP3 SL-1 ST1 matrix metalloproteinase 3 matrix metalloproteinase-3 proteoglycanase stromelysin 1 transin-1 MIO:02494 The ratio between the levels of myoglobin and carbonic anhydrase 3. myoglobin/carbonic anhydrase 3 ratio MIO:02495 The ratio between the levels of undercarboxylated osteocalcin and total osteocalcin. undercarboxylated osteocalcin/total osteocalcin ratio PMID:15350706 PMID:32820656 MIO:02496 MR-proADM contains amino acids 45-92, which directly reflects the level of rapidly degraded active peptide ADM. [url:https://pubmed.ncbi.nlm.nih.gov/15350706/] mid-regional pro-adrenomedullin MR-proADM mid-regional fragment of pro-adrenomedullin mid-regional part of the prohormone of adrenomedullin mid-regional proadrenomedullin midregional pro-adrenomedullin midregional proadrenomedullin PR:P48061-2 MIO:02497 A stromal cell-derived factor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48061-2.|Category=organism-sequence. [url:http://purl.obolibrary.org/obo/PR_P48061-2] stromal cell-derived factor 1 isoform Alpha hCXCL12/iso:Alpha stromal cell-derived factor 1 isoform SDF-1-alpha(1-68) stromal cell-derived factor 1 isoform hSDF-1alpha NCIT:C16819 MIO:02498 Superoxide dismutase [Mn], mitochondrial (222 aa, ~25 kDa) is encoded by the human SOD2 gene. This protein plays a role in superoxide reduction. [url:http://purl.obolibrary.org/obo/NCIT_C16819 superoxide dismutase [Mn], mitochondrial ec 1.15.1.1 ipo-b manangese superoxide dismutase manganese superoxide dismutase mitochondrial superoxide dismutase mitochondrial superoxide dismutase 2 mn superoxide dismutase mnsod sod2 superoxide dismutase 2 superoxide dismutase [mn], mitochondrial MIO:02499 The ratio between the levels of interleukin-33 and suppression of tumorigenicity 2. interleukin-33/suppression of tumorigenicity 2 ratio MIO:02500 The ratio between the levels of tumor necrosis factor and interleukin-10. tumor necrosis factor/interleukin-10 ratio PMID:20493567 MIO:02501 The carboxy-terminal telopeptide of type I collagen (ICTP) reflects collagen type I degradation.[PMID:20493567] type I collagen C-telopeptide MIO:02502 The ratio between the levels of type III procollagen N-terminal peptide and type I collagen C-telopeptide. type III procollagen N-terminal peptide/type I collagen C-telopeptide ratio MIO:02503 The ratio between the levels of anti-angiogenic isoform of vascular endothelial growth factor A and total vascular endothelial growth factor A. anti-angiogenic isoform of vascular endothelial growth factor A to total vascular endothelial growth factor A ratio MIO:02504 The ratio between the levels of copeptin and troponin T. vasopressin-neurophysin 2-copeptin/troponin T, cardiac muscle ratio SO:0001877 MIO:02505 A non-coding RNA over 200 nucleotides in length. [ https://www.genenames.org/data/gene-symbol-report/!/hgnc_id/HGNC:mw ] lncRNA INSDC_qualifier:lncRNA lncRNA_transcript long non-coding RNA BAO:0000322 MIO:02506 miRNAs or microRNAs are short RNAs (~22 nucleotides long) that bind to complementary sequences in the three prime untranslated regions (3' UTRs) of target messenger RNA transcripts (mRNAs), usually resulting in gene silencing. [url:http://www.bioassayontology.org/baoBAO_0000322] miRNA miRNAs micro RNA micro ribonucleic acid microRNA microRNAs MIO:02507 Quantification of the ratio between absolute lymphocyte count and absolute monocyte count. lymphocyte to monocyte ratio MIO:02508 The ratio between the levels of monocyte and high-density lipoprotein cholesterol. monocyte to high-density lipoprotein cholesterol ratio HP:0011014 MIO:02509 An abnormality of any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [url:http://purl.obolibrary.org/obo/HP_0011014] abnormal glucose homeostasis abnormal glucose level dysglycaemia dysglycemia MIO:02510 Aspirin (acetylsalicylic acid) is a classic nonsteroidal antiinflammatory agent that irreversibly inhibits type I cyclooxygenase (PTGS1, or COX1; 176805) in platelets, resulting in decreased production of thromboxane A2 (TXA2) and inhibition of platelet aggregation. Because of this feature, it is used therapeutically to prevent cardiothrombotic events. Individuals show a variable response to the drug, referred to as aspirin ineffectiveness or resistance, in which not all individuals or populations appear to receive the full prophylactic or therapeutic benefits. [url:https://omim.org/entry/608223] aspirin resistance resistance to antithrombotic effect of aspirin resistance to cardioprotective effect of aspirin HP:0030965 MIO:02511 The elastic properties of the aorta allow the aorta to store half of the cardiac ejected blood volume per beat, whereby aortic recoil during diastole pushes the remaining stored volume forward into the peripheral circulation, a phenomenon known as the Windkessel function. Aortic stiffness occurs as the elastic fibers within the arterial wall become disrupted due to mechanical stress (with age or due to other factors). Aortic stiffness refers to a reduction in the elasticity of the aorta, which is associated with an elevated pulse pressure, increased wave reflection, and often hypertension. [url:http://purl.obolibrary.org/obo/HP_0030965] aortic stiffness increased aortic stiffness PMID:33451925 MIO:02512 A lesion was defined as type-C according to the American College of Cardiology/American Heart Association Task Force (ACC/AHA) classification with the following parameters: lesion length >20 mm, excessive tortuosity of proximal segment, angulated segments >90掳, total occlusion older than 3 months, inability to protect major side branches, or degenerated vein grafts. [PMID:33451925] type C lesion MIO:02513 type D bifurcation lesion NCIT:C101233 MIO:02514 A lesion found in the division of a vessel into at least two branches, each of which is 1.5 mm or greater in diameter. [url:http://purl.obolibrary.org/obo/NCIT_C101233] coronary vessel bifurcation lesion bifurcation lesion bifurcation lesions coronary bifurcation lesion PMID:17643584 MIO:02515 Lesions were considered complex if they caused at least 50% stenosis and had 2 or more of the following morphological features : (a) ulceration (sacciform extraluminal opacification), (b) irregularities or a crenated edge, (c) sharp stenosis angulation in the wall, and (d) endoluminal defects compatible with a thrombus. An MCL was recorded when there were at least 2 complex lesions within the same artery separated by a 3-cm segment of the healthy or only slightly pathological artery. [url:https://pubmed.ncbi.nlm.nih.gov/17643584/] multiple complex coronary lesions MCL multiple complex lesions multiple vessel lesions SNOMED:373138006 MIO:02516 ulcerated lesion of coronary artery lesion ulceration of coronary artery EFO:0010284 MIO:02517 A non-neoplastic or neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples of non-neoplastic disorders include hepatitis, cirrhosis, cholangitis, and cholecystitis. Representative examples of neoplastic disorders include hepatocellular adenoma, hepatocellular carcinoma, and cholangiocarcinoma. [url:http://www.ebi.ac.uk/efo/EFO_0010284] hepatobiliary disease disease of hepatobiliary system disease or disorder of hepatobiliary system disorder of hepatobiliary system hepatobiliary disease hepatobiliary disorder hepatobiliary system disease hepatobiliary system disease or disorder liver and biliary disease liver and biliary disorder liver and biliary system disorder liver and biliary tract disease EFO:0009605 MIO:02518 A non-neoplastic or neoplastic disorder that affects the pancreas. Representative examples of non-neoplastic disorders include pancreatitis and pancreatic insufficiency. Representative examples of neoplastic disorders include cystadenomas, carcinomas, lymphomas, and neuroendocrine neoplasms. [url:http://www.ebi.ac.uk/efo/EFO_0009605] pancreas disease disease of pancreas disease or disorder of pancreas disorder of pancreas pancreas disease pancreas disease or disorder pancreas problem pancreatic disorder NCIT:C63743 MIO:02519 An inflammatory process of the gingival tissues and/or periodontal membrane of the teeth, resulting in an abnormally deep gingival sulcus, possibly producing periodontal pockets and loss of alveolar bone support. [url:http://purl.obolibrary.org/obo/NCIT_C63743] periodontal disorder periodontal disease NCIT:C3318 UMLS:C4012822 MIO:02520 A mucosal injury that occurs in the stomach or duodenum. A break in the lining of the lower part of the esophagus, the stomach, or the upper part of the small intestine. Peptic ulcers form when cells on the surface of the lining become inflamed and die. They are usually caused by Helicobacter pylori bacteria and by certain medicines, such as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Peptic ulcers may be linked to cancer and other diseases. [url:http://purl.obolibrary.org/obo/NCIT_C3318] peptic ulcer disease peptic ulcer HP:0012224 MIO:02521 Immune complexes are formed of interlocking antigens and antibodies and are normally are rapidly removed from the bloodstream by macrophages in the spleen and Kupffer cells in the liver. If they persist abnormally in the circulation, they may become trapped in various tissues and induce inflammatory reactions.[url:http://purl.obolibrary.org/obo/HP_0012224] Persistence of immune complexes in the blood circulation. [url:http://purl.obolibrary.org/obo/HP_0012224] circulating immune complexes NCIT:C113712 SNOMED:43355006 MIO:02522 Abnormally low level of eosinophils in the blood. [url:http://purl.obolibrary.org/obo/NCIT_C113712] eosinopenia eosinophilic cytopenia SNOMED:103624008 MIO:02523 severe inflammation EFO:0007486 MIO:02524 An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity. [url:http://www.ebi.ac.uk/efo/EFO_0007486] sinusitis MC:2000755 MIO:02525 Leukocytosis has been considered only for increased leukocytes in the vessels, and not for leukocytes infiltrating the tissues. Those synonyms have been mapped in the respective inflammatory cell infiltration/inflammation child terms[url:http://purl.obolibrary.org/obo/MC_2000755] Leukocytosis represent an increase in the number of leukocytes (white blood cells) above the normal range in the blood. It is used in histology to describe blood vessels enriched in white blood cells. This finding is usually associated with inflammation and/or infection, however it can be associated to other non-inflammatory causes (blood tumors, strenuous exercise, convulsions such as epilepsy, emotional stress, pregnancy and labour, anesthesia, and epinephrine administration) [url:http://purl.obolibrary.org/obo/MC_2000755] leukocytosis leucocytosis leucocytostasis EFO:1001249 MIO:02526 Fatty replacement and damage to the hepatocytes not related to alcohol use. It may lead to cirrhosis and liver failure. [url:http://www.ebi.ac.uk/efo/EFO_1001249] non-alcoholic steatohepatitis NASH nash - nonalcoholic Steatohepatitis non alcoholic steatohepatitis nonalcoholic steatohepatitis NCIT:C94832 MIO:02527 A generalized state of dysregulated inflammation induced by noninfectious processes. It is characterized by two or more of the following signs and symptoms: fever or hypothermia, increased heart rate, increased respiratory rate, and abnormal white blood cell count. [url:http://purl.obolibrary.org/obo/NCIT_C94832] systemic inflammatory response syndrome SIRS MP:0012549 MIO:02528 subnormal arterial oxygen tension; deficient oxygenation of arterial blood [ https://www.worldcat.org/search?q=bn%3A978-0-387-75246-4 ] [url:http://purl.obolibrary.org/obo/MP_0012549] hypoxemia decreased blood partial O2 level hypoxaemia NCIT:C96210 MIO:02529 Chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury. [url:http://purl.obolibrary.org/obo/NCIT_C96210] neuropathic pain MIO:02530 nonunion of humerus fracture EFO:0003964 MIO:02531 Traumatic or pathological injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken. Symptoms include pain in the hip or groin, bruising and swelling in and around the hip area. The injured hip is turned outward and the leg appears shorter on that side. [url:http://www.ebi.ac.uk/efo/EFO_0003964] hip fracture hip fractures intertrochanteric fractures subtrochanteric fractures trochanteric fractures NCIT:C26795 MIO:02532 A traumatic or pathologic injury to the humerus in which the continuity of the humerus is broken. [url:http://purl.obolibrary.org/obo/NCIT_C26795] humerus fracture fracture of humerus NCIT:C80097 MIO:02533 A pathologic bone fracture due to osteoporosis. It is generally caused by a fall from a standing height or lower and usually involves the spine, hip, or wrist. [url:http://purl.obolibrary.org/obo/NCIT_C80097] osteoporotic fracture low-trauma fracture MIO:02534 Chinese medicine decoction MIO:02535 Chinese patent medicine (simplified Chinese: 科学中药; traditional Chinese: 科學中藥; pinyin: kēxúe zhōngyào; lit. 'scientific Chinese medicine') are herbal medicines in Traditional Chinese medicine, modernized into a ready-to-use form such as tablets, oral solutions or dry suspensions, as opposed to herbs that require cooking (hot water extraction). [url:https://en.wikipedia.org/wiki/Chinese_patent_medicine] Chinese patent medicine Chinese patent medicines NCIT:C1128 MIO:02536 A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. [url:http://purl.obolibrary.org/obo/NCIT_C1128] leflunomide 4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)- SU101 arava NCIT:C642 MIO:02537 An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. [url:http://purl.obolibrary.org/obo/NCIT_C642] methotrexate 4-amino-10-methylfolic acid 4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid CL 14377 CL-14377 MTX N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid WR-19039 abitrexate alpha-methopterin amethopterin brimexate emtexate emthexat emthexate farmitrexat fauldexato folex folex PFS lantarel ledertrexate lumexon maxtrex medsatrexate metex methoblastin methotrexate methotrexate LPF methotrexate methylaminopterin methotrexatum metotrexato metrotex mexate mexate-AQ novatrex rheumatrex texate tremetex trexeron trixilem NCIT:C94725 MIO:02538 Any agent that increases the extracellular level of the neurotransmitter serotonin (5-HT) by inhibiting its reuptake into the presynaptic cell. Increased level in the synaptic cleft prolongs the action of 5-HT on the postsynaptic receptor. This type of agent is typically used as an antidepressant and in the treatment of anxiety disorders and some personality disorders. They are also typically effective and used in treating some cases of insomnia. [url:http://purl.obolibrary.org/obo/NCIT_C94725] selective serotonin reuptake inhibitor SSRI SSRIs selective serotonin reuptake inhibitors NCIT:C15409 MIO:02539 The intravenous administration of red blood cells (whole blood without the plasma) into an individual. [url:http://purl.obolibrary.org/obo/NCIT_C15409] packed red blood cell transfusion PRBC transfusion packed red blood cells transfusion transfusion of packed red blood cells NCIT:C15248 MIO:02540 A therapeutic procedure used in patients with kidney failure. It involves the extracorporeal removal of harmful wastes and fluids from the blood using a dialysis machine. Following the dialysis, the blood is returned to the body. [url:http://purl.obolibrary.org/obo/NCIT_C15248] hemodialysis artificial kidney dialysis extracorporeal dialysis kidney dialysis renal dialysis SNOMED:89666000 MIO:02541 Cardiopulmonary resuscitation (CPR) is an emergency procedure that combines chest compressions often with artificial ventilation in an effort to manually preserve intact brain function until further measures are taken to restore spontaneous blood circulation and breathing in a person who is in cardiac arrest. It is recommended in those who are unresponsive with no breathing or abnormal breathing, for example, agonal respirations. [url:https://en.wikipedia.org/wiki/Cardiopulmonary_resuscitation] cardiopulmonary resuscitation CPR ECTO:9000316 MIO:02542 exposure to nitric oxide ECTO:9000252 NCIT:C29843 MIO:02543 Found in the atmosphere as a key ingredient in photochemical formation of smog and acid rain, Nitrogen Dioxide is a poisonous gas that forms during combustion. Toxic at high concentrations, it reacts with moisture in the air to form nitric acid, highly corrosive and hazardous to plants and animals.[url:http://purl.obolibrary.org/obo/NCIT_C29843] exposure to nitrogen dioxide NO2 exposure to NO2 nitrogen dioxide PMID:29020374 MIO:02544 Asian Dust (also yellow dust, yellow sand, yellow wind or China dust storms) is a meteorological phenomenon that affects much of East Asia year-round and especially during the spring months. The dust originates in China, the deserts of Mongolia, and Kazakhstan where high-speed surface winds and intense dust storms kick up dense clouds of fine, dry soil particles. These clouds are then carried eastward by prevailing winds and pass over China, North and South Korea, and Japan, as well as parts of the Russian Far East. [url:https://en.wikipedia.org/wiki/Asian_Dust] exposure to Asian dust Asian dust exposure exposure to China dust storms exposure to yellow dust exposure to yellow sand exposure to yellow wind PMID:25074374 MIO:02545 Desert dust clouds carry not only coarse particles but also fine particles and various chemical components from anthropogenic sources during its long-range transport.[url:https://pubmed.ncbi.nlm.nih.gov/25074374/] exposure to desert dust desert dust SNOMED:386620006 MIO:02546 no added salt diet avoidance of added salt PMID:18936332 MIO:02547 Oriental dietary pattern (high intake of tofu and soy and other sauces). [url:https://pubmed.ncbi.nlm.nih.gov/18936332/] Oriental dietary pattern Oriental diet PMID:28376792 MIO:02548 A pro-inflammatory diet, as estimated by the dietary inflammatory index (DII), has been associated with an increased risk of CVD in several populations. [url:https://pubmed.ncbi.nlm.nih.gov/28376792/] pro-inflammatory diet PMID:18936332 MIO:02549 prudent dietary pattern (high in fruit and vegetables) [url:https://pubmed.ncbi.nlm.nih.gov/18936332/] prudent dietary pattern PMID:16465200 MIO:02550 Staple diet pattern was characterized by an increased use of palm oil for cooking, and intake of refined grains (mostly white rice and white bread), legumes, coffee, added sugar, and red meat. [url:https://pubmed.ncbi.nlm.nih.gov/16465200/] staple dietary pattern staple diet pattern OMIT:0028876 PMID:18936332 MIO:02551 Western dietary pattern (high in fried foods, salty snacks, eggs, and meat). [url:https://pubmed.ncbi.nlm.nih.gov/18936332/] Western dietary pattern Western diet EFO:0004330 MIO:02552 Behaviors associated with the ingesting of coffee [url:http://www.ebi.ac.uk/efo/EFO_0004330] coffee consumption caffeine consumption coffee drinking coffee intake consumption of coffee SNOMED:226383006 MIO:02553 tea intake tea consumption NCIT:C102342 MIO:02554 In an individual with a right-dominant heart, the arterial branch that arises from the distal right coronary artery between the acute marginal artery and the first right posterolateral segment. It supplies the inferior apex of the heart. [url: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102342] right posterior descending artery RPDA right posterior descending artery segment SNOMED:391129005 MIO:02555 fruit and vegetable intake consumption of fruit and vegetables consumption of fruits or vegetables consumption of vegetables and fruits consumption of vegetables and/or fruits fruit and vegetable consumption fruit and vegetables take vegetable and fruit consumption vegetable and fruit intake SNOMED:226426002 MIO:02556 meat intake SNOMED:226403009 MIO:02557 dairy food intake dairy food consumption SNOMED:230112002 MIO:02558 fast food intake convenience food intake fast food consumption SNOMED:226441002 MIO:02559 fish intake fish consumption SNOMED:230098001 MIO:02560 fried food intake intake of fried foods SNOMED:228031004 MIO:02561 high glycemic index food high dietary GI high dietary glycaemic index high dietary glycemic index MIO:02562 Khat or qat is a flowering plant native to the East and West Hararghe zones of Ethiopia. Khat contains the alkaloid cathinone, a stimulant, which is said to cause excitement, loss of appetite, and euphoria. Among communities from the areas where the plant is native, khat chewing has a history as a social custom dating back thousands of years analogous to the use of coca leaves in South America and betel nut in Asia.[url:https://en.wikipedia.org/wiki/Khat] Khat chewing MIO:02563 seafood intake eating seafood seafood consumption MIO:02564 dietary fat intake NCIT:C70554 MIO:02565 A class of polyphenols which are biogenetically derived from a phenylpropane (C6-C3 unit) and three C2 units to form a benzopyran with an additional phenyl group at C-2 (C6-C3-C6 unit). They consist of 15 carbons and vary by oxidation/hydroxylation, glycosidation, and other functional groups. Historically, the benzene ring is denoted 'A'-ring, the pyran ring 'C' ring, and the phenyl ring 'B'-ring. The numbering of the phenyl ring starts with 1' (""one prime"") at the carbon that is connected to the pyran ring, and follows along the phenyl ring with C-2', -3', -4', -5', and -6'.[url:http://purl.obolibrary.org/obo/NCIT_C70554] dietary flavonoid intake flavonoid flavonoid intake intake of total flavonols SNOMED:226352007 MIO:02566 mineral intake MAXO:0001129 SNOMED:226349004 MIO:02567 Addition of Vitamin to the diet for adequate and complete nutrition. [url:http://purl.obolibrary.org/obo/MAXO_0001129] vitamin intake dietary supplementation of Vitamin intake of vitamin supplementation of vitamin supplementation with vitamin vitamin supplemental intake NCIT:C344 SNOMED:788472008 MIO:02568 A sugar molecule. Carbohydrates can be small and simple (for example, glucose) or they can be large and complex (for example, polysaccharides such as starch, chitin or cellulose).[url:http://purl.obolibrary.org/obo/NCIT_C344] carbohydrate intake carbohydrate carbohydrates NCIT:C68492 SNOMED:162520006 MIO:02569 Compounds in food which are not digested by the digestive processes in the human stomach or small intestine. In food, fiber is the part of fruits, vegetables, legumes, and whole grains that cannot be digested. The fiber in food may help prevent cancer. In the body, fiber refers to tissue made of long threadlike cells, such as muscle fiber or nerve fiber.[url:http://purl.obolibrary.org/obo/NCIT_C68492] dietary fiber intake daily intake of fiber fiber intake NCIT:C68511 NCIT:C68513 MIO:02570 A term used to describe the Recommended Dietary Allowance of folate; the term accounts for the easier absorption of folate in supplements and fortified foods as compared with the absorption of folic acid found naturally in foods. One Dietary Folate Equivalent (DFE) = 1 microgram food folate = 0.6 microgram folic acid from supplements and fortified food. [url:http://purl.obolibrary.org/obo/NCIT_C68511] dietary folate intake dietary folate NCIT:C68441 SNOMED:162534006 MIO:02571 A macronutrient which forms the major structural components of all the cells of the body. They can function as enzymes, membrane carriers, and hormones.[url:http://purl.obolibrary.org/obo/NCIT_C68441] dietary protein intake dietary protein protein intake SNOMED:787787004 MIO:02572 Total number of calories taken in daily whether ingested or by parenteral routes. [url:http://www.ebi.ac.uk/efo/EFO_0003939] energy intake caloric intake NCIT:C148542 MIO:02573 Carbonated, iron-depleted mineral water from the French springs of Beauregard-Vendon (Rouzat) containing very high amounts of the mineral magnesium as well as sodium, calcium, potassium, bicarbonate, sulfate, chloride and nitrate, that can be used for supplemental purposes and can potentially be used to treat hypomagnesemia. Magnesium, an electrolyte, plays a key role as a cofactor in multiple enzymatic reactions and for muscle and nervous system functioning. Hypomagnesemia may manifest as asthenia, cramps, muscle weakness, fatigue, and mood disorders. [url:http://purl.obolibrary.org/obo/NCIT_C148542] magnesium-rich mineral water magnesium in drinking water rozana DOID:9505 MIO:02574 A substance abuse that involves the recurring use of cannabis despite negative consequences. [url:http://purl.obolibrary.org/obo/DOID_9505] cannabis abuse marijuana abuse PMID:29788961 SNOMED:226111008 MIO:02575 low saturated fat diet diet low in saturated fat diets low in saturated fat low consumption of saturated fat low intake saturatedfat low saturated fat intake low saturated fatintake low-saturated fat dietary PMID:6023859 SNOMED:386615006 MIO:02576 The most cogent evidence so far is the epidemiological evidence that showed that the habitual intake of suger by men who developed myocardial infarction had been on the average twice as great as that of men of the same age wih no manifest arterial disease.[url:https://pubmed.ncbi.nlm.nih.gov/6023859/] low sugar diet low sugar consumption low sugar intake MIO:02577 age under 60 years age 59 years or younger age </=59 years age <60 years age below 60 years age ≤59 years aged <60 years aged under 60 years under 60 years of age under 60 years old MIO:02578 age above 45 years above 45 years of age age 46 years or older age >/=46 years age >45 years age of more than 45 age over 45 years age ≥46 years aged >45 years aged over 45 aged over 45 years at least 46 years of age at least 46 years old over 45 years of age over 45 years old PMID:27924760 MIO:02579 P-wave dispersion: is defined as the difference between the maximum and the minimum P-wave duration recorded from multiple different-surface ECG leads. [url:https://pubmed.ncbi.nlm.nih.gov/27924760/] P wave dispersion P-wave dispersion P-wave dispersion (PWD, Pd or Pdis) EFO:0008379 PMID:23160859 MIO:02580 PTFV1 was calculated by multiplying the depth and the duration of the terminal negative component of the P wave in lead V1 (mm * ms). [url:https://pubmed.ncbi.nlm.nih.gov/23160859/] P terminal force in lead V1 P-wave terminal force V1 P-wave terminal force in lead V1 PtfV1 PMID:29174098 MIO:02581 the ratio of sum of precordial Q wave duration to sum of precordial R wave duration [PMID:29174098] sum of precordial Q wave duration/sum of precordial R wave duration ratio PMID:12687848 MIO:02582 The total cosine between R and T (TCRT) (angular difference between the spatial QRS and T wave loops) is a technical elaboration of the concept of ventricular gradient (VG), whose power as a risk stratifier in post-MI patients has already been demonstrated. [PMID:12687848] total cosine between R and T TCRT co-sine of the angle between the main vectors of the T wave loop and QRS loop PMID:12151568 MIO:02583 The normal value of corrected QT dispersion is less than 60 milliseconds. The corrected QT interval (QTc) was calculated according to Bazett’s formula and QTc dispersion were calculated as the difference between the maximum and minimum QTc intervals. [url:https://pubmed.ncbi.nlm.nih.gov/12151568/] corrected QT dispersion QTc dispersion QTcD PMID:32592427 MIO:02584 WLR ST deviation was defined as the absolute mm magnitude of residual ST deviation in the most affected lead on the one-hour ECG, without reference to the baseline ECG. [PMID:32592427] worst lead residual ST deviation PMID:26385452 MIO:02585 (1) incomplete (non-negative) STD-R defined as <50% and (2) complete STD-R (50–100%)—we defined category (3) as worsened STD (<0%). [url:https://pubmed.ncbi.nlm.nih.gov/26385452/] ST segment depression resolution ST segment depression normalization ST-segment depression resolution STD-R resolution of ST segment depression PMID:8034872 MIO:02586 1) complete resolution (> or = 70%) or only slight ST segment elevation; 2) partial resolution (< 70% to 30%); 3) no resolution (< 30% to > 0%) [url:https://pubmed.ncbi.nlm.nih.gov/8034872/] ST segment elevation resolution ST-elevation resolution ST-segment elevation resolution STE-R resolution of ST segment elevation PMID:16442395 MIO:02587 T wave loop dispersion is a descriptor of the normalized T wave loop length, it measures spatial irregularities of the T wave loop during its time course. The normalized T wave loop area determines the area of the normalized T wave loop as a unitless fraction of a rectangular area encompassing it. [url:https://pubmed.ncbi.nlm.nih.gov/12114858/] T wave loop dispersion TWLD PMID:19279023 MIO:02588 The TLL describes the length of the T-wave vector loop with smaller T-waves resulting in shorter vector loops and smaller TLL values.[PMID:19279023] T-wave vector loop length TLL MIO:02589 The ratio between T-peak to T-end interval and QT interval. T-peak to T-end interval/QT interval ratio Tp-e/QT Tp-e/QT ratio TpTe/QT TpTe/QT ratio ratio ratio of Tp-e to QT interval PMID:22943640 MIO:02590 Corrected Tp-e interval (Tp-ec) was defined as the time between the highest point of the T wave and the tangent of the maximum slope of the T wave drop branch and the intersection of the isopotential line. [url:https://pubmed.ncbi.nlm.nih.gov/22943640/] corrected T-peak to T-end interval Tp-ec corrected Tp-e interval MIO:02591 T-peak to T-end interval of premature ventricular complex PMID:22950360 MIO:02592 TO is calculated as: TO = 100* ((RR1 + RR2) -(RR-2 + RR-1)) /(RR-2 + RR-1) where RR-2 and RR-1 are the two RR intervals immediately preceding the VPC coupling interval, and RR1 and RR2 are two RR intervals immediately after the compensatory pause. [url:https://pubmed.ncbi.nlm.nih.gov/22950360/] turbulence onset TO turbulence onset (TO) PMID:22950360 MIO:02593 TS is defined as the maximum positive regression slope assessed over any 5 consecutive sinus rhythm RR intervals within the first 15 sinus rhythm RR intervals after the VPC. [url:https://pubmed.ncbi.nlm.nih.gov/22950360/] turbulence slope TS turbulence slope (TS) PMID:32163924 MIO:02594 frequency-domain index frequency-domain indexes frequency-domain indices PMID:15673380 MIO:02595 nonlinear index nonlinear HRV indices nonlinear heart rate variability nonlinear indexes PMID:32163924 MIO:02596 time-domain index time-domain indexes time-domain indices MONDO:0002009 MIO:02597 An episode of depression lasting two or more weeks without an intervening episode of mania. [url:http://purl.obolibrary.org/obo/NCIT_P378] major depressive disorder NCIT:C48801 MIO:02598 A condition characterized by excessive fatigue and lack of energy, increasing irritability, and feelings of demoralization. Persons who experience this condition are not at an increased risk for cancer. [url:http://purl.obolibrary.org/obo/NCIT_C48801] vital exhaustion exhaustion OAE:0000240 MIO:02599 a behavior and neurological AE that has an outcome of stress in a patient [url:http://purl.obolibrary.org/obo/OAE_0000240] stressful life event acute life event adverse life events stress AE stress adverse events stressful life events MIO:02600 Stress from marriage. marital stress OPMI:0000132 MIO:02601 no formal school education level illiteracy lack of education no education uneducated SNOMED:473463000 MIO:02602 received elementary school education primary education OPMI:0000133 MIO:02603 An education level that indicates that the highest level of education achievement for a person is a high school completion. [url:http://purl.obolibrary.org/obo/OPMI_0000133] high school education level high school graduates SNOMED:224300008 MIO:02604 received university education NCIT:C19290 MIO:02605 A blue-collar worker is a working class person who performs manual labor. Blue-collar work may involve skilled or unskilled labor. The type of work may involve manufacturing, warehousing, mining, excavation, electricity generation and power plant operations, electrical construction and maintenance, custodial work, farming, commercial fishing, logging, landscaping, pest control, food processing, oil field work, waste collection and disposal, recycling, construction, maintenance, shipping, driving, trucking and many other types of physical work. Blue-collar work often involves something being physically built or maintained. [url:https://en.wikipedia.org/wiki/Blue-collar_worker] blue-collar worker Blue-Collar blue collar job blue collar jobs NCIT:C77922 MIO:02606 Refers to workers who perform work that is knowledge intensive and generally non-routine and unstructured. [url:http://purl.obolibrary.org/obo/NCIT_C77922] white collar worker white collar job white collar jobs MIO:02607 Obesity with a body mass index of 35 to 39.9 kg per square meter. [url:http://purl.obolibrary.org/obo/HP_0025500] class II obesity BMI 35.0 to 39.9 BMI 35.0-39.9 body mass index 35.00 to 39.99 obese class II obesity grade 2 HP:0025501 MIO:02608 Obesity with a body mass index of 40 kg per square meter or higher. [url:http://purl.obolibrary.org/obo/HP_0025501] class III obesity BMI > or =40 BMI ≥ 40.0 body mass index equal to or greater than 40 obese class III obesity grade 3 MIO:02609 age above 60 years above 60 years of age age >/=61 years age >60 years age of more than 60 age over 60 years aged >60 years aged over 60 aged over 60 years at least 61 years of age at least 61 years old over 60 years of age MIO:02610 age between 60 and 75 years 60-75 years old age 60-75 PMID:28887316 PMID:33249775 MIO:02611 The primary end point of the present study was the incidence of MACCE, defined as a composite of cardiac death, nonfatal myocardial reinfarction, new congestive heart failure, and stroke. [url:https://pubmed.ncbi.nlm.nih.gov/28887316/] major adverse cardiac and cerebral events MACCE MACCEs major acute cardiovascular and cerebrovascular events major adverse cardiac and cerebrovascular events major adverse cardio-cerebrovascular event major adverse cardiovascular and cerebral events major adverse cardiovascular and cerebrovascular events NCIT:C54196 MIO:02612 The cessation of life due to cardiovascular disease. cardiovascular death CD CV death CVD mortality cardiac death cardiac mortality cardiovascular disease mortality cardiovascular mortality coronary death coronary deaths heart mortality PMID:32213303 MIO:02613 non-cardiac death non-cardiac mortality NCIT:C107103 MIO:02614 An unexpected death without warning. [url:http://purl.obolibrary.org/obo/NCIT_C107103] sudden death sudden mortality PMID:30167806 MIO:02615 readmission due to cardiovascular disease HACS cardiac readmission cardiac readmissions cardiovascular hospitalization cardiovascular re-admission cardiovascular readmission cardiovascular readmissions hospitalization due to acute coronary symptoms readmission due to CVD recurrent coronary hospitalizations PMID:30167806 MIO:02616 readmission due to non-cardiovascular disease non-CV hospitalization non-cardiovascular hospitalization readmission due to non-CVD GSSO:001810 MIO:02617 A limitation on a person's mental functioning or intellectual capacity. [url:http://purl.obolibrary.org/obo/GSSO_001810] mental disability feelings of being disabled mental handicap GSSO:001811 MIO:02618 A limitation on a person's physical functioning, mobility, dexterity or stamina. [url:http://purl.obolibrary.org/obo/GSSO_001811] physical disability CHEBI:3380 NCIT:C340 UMLS:C0006938 MIO:02619 A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. [url:http://purl.obolibrary.org/obo/NCIT_C340] captopril NCIT:C76133 UMLS:C0055723 MIO:02620 A pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C76133] cilazapril monohydrate (1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid 9-ethyl ester monohydrate Ro 31-2848 monohydrate cilazapril CHEBI:4784 NCIT:C62027 UMLS:C0014025 MIO:02621 A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C62027] enalapril CHEBI:5163 NCIT:C65761 UMLS:C0118168 MIO:02622 A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C65761] fosinopril NCIT:C72908 MIO:02623 An angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C72908] imidapril (S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid CHEBI:8024 NCIT:C72910 UMLS:C0136123 MIO:02624 A non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. [url:http://purl.obolibrary.org/obo/NCIT_C72910] perindopril (2S,3aS,7aS)-1-((S)-N-((S)-1-carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester S-9490 CHEBI:8713 NCIT:C62074 UMLS:C0072857 MIO:02625 A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels. [url:http://purl.obolibrary.org/obo/NCIT_C62074] quinapril NCIT:C29411 MIO:02626 A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. [url:http://purl.obolibrary.org/obo/NCIT_C29411] ramipril altace NCIT:C61978 MIO:02627 A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C61978] trandolapril Mavik CHEBI:4814 NCIT:C61749 UMLS:C0287041 MIO:02628 A competitive and reversible angiotensin II receptor antagonist with anti-hypertensive property. Eprosartan blocks the binding of angiotensin II to the angiotensin (AT)1 receptor in vascular smooth muscle, thereby blocking the principal pressor action of angiotensin II on the renin-angiotensin system resulting in vascular dilatation. In addition, this agent blocks angiotensin II -induced stimulation of aldosterone synthesis and secretion by the adrenal cortex, cardiac contraction, renal resorption of sodium, activity of the sympathetic nervous system, and smooth muscle cell growth. Furthermore, eprosartan inhibits sympathetic norepinephrine production, thereby further reducing blood pressure. [url:http://purl.obolibrary.org/obo/NCIT_C61749] eprosartan CHEBI:6541 NCIT:C66869 UMLS:C0126174 MIO:02629 A non-peptide angiotensin II antagonist with antihypertensive activity. Upon administration, losartan and its active metabolite selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. This blocks the vasoconstricting and aldosterone-secreting actions of angiotensin II, leading to a decrease in blood pressure. Angiotensin II, formed from angiotensin I by angiotensin-converting enzyme (ACE), stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. [url:http://purl.obolibrary.org/obo/NCIT_C66869] losartan 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol CHEBI:9927 NCIT:C47781 UMLS:C0216784 MIO:02630 An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium, and resulting in vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure. [url:http://purl.obolibrary.org/obo/NCIT_C47781] valsartan CGP 48933 L-Valine N-(1-oxopentyl)-N-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine diovan MIO:02631 laboratory primary coronary angioplasty volume primary coronary angioplasty volume MIO:02632 primary percutaneous transluminal coronary angioplasty direct PTCA direct percutaneous transluminal coronary angioplasty emergency PTCA emergency percutaneous transluminal coronary angioplasty primary PTCA NCIT:C150145 MIO:02633 The nominal diameter of the balloon per manufacturer specification. [url:http://purl.obolibrary.org/obo/NCIT_C150145] catheter balloon diameter balloon diameter catheter balloon diameter nominal diameter PMID:17239694 MIO:02634 Complete revascularization was defined when no total occlusion and no residual stenosis >70% were found in any major coronary artery or their major branches at discharge. [url:https://pubmed.ncbi.nlm.nih.gov/17239694/] complete revascularization CR PMID:17239694 MIO:02635 IR is more commonly observed in patients with diabetes, hyperlipidemia and arterial hypertension. IR was found to be more common in female patients than in males perhaps due to higher incidence of small coronaries.[url:https://pubmed.ncbi.nlm.nih.gov/35242372/] incomplete revascularization ICR IR CHEBI:59173 NCIT:C47415 UMLS:C0168273 MIO:02636 A 20 amino acid long synthetic peptide with thrombin-specific anticoagulant properties. Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors. This drug is primarily used during coronary angioplasty procedures, in combination with aspirin, in patients with unstable angina. [url:http://purl.obolibrary.org/obo/NCIT_C47415] bivalirudin L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl- angiomax angiox bivalitroban hirulog NCIT:C1839 MIO:02637 A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis. [url:http://purl.obolibrary.org/obo/NCIT_C1839] lepirudin r-hirudin recombinant hirudin refludan NCIT:C1453 MIO:02638 A low molecular weight, synthetic heparin. As an anticoagulant/antithrombotic agent, dalteparin binds to antithrombin and enhances the inhibition of Factor Xa. Compared to unfractionated heparins, the use of dalteparin is associated with lower incidences of osteoporosis and heparin-induced thrombocytopenia. [url:http://purl.obolibrary.org/obo/NCIT_C1453] dalteparin CHEBI:28304 NCIT:C1452 UMLS:C0206460 MIO:02639 A low molecular weight, synthetic heparin. As an anticoagulant/antithrombotic agent, enoxaprin's mechanism of action is similar to that of heparin, although it exhibits a higher ratio of anti-Factor Xa to anti-Factor IIa activity. This agent also has anti-inflammatory properties, inhibiting monocyte adhesion to tumor necrosis factor alpha- or lipopolysaccharide-activated endothelial cells. Compared to unfractionated heparins, the use of enoxaparin is associated with lower incidences of osteoporosis and heparin-induced thrombocytopenia. [url:http://purl.obolibrary.org/obo/NCIT_C1452] enoxaparin NCIT:C945 UMLS:C0043031 MIO:02640 A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. [url:http://purl.obolibrary.org/obo/NCIT_C945] warfarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin 3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one WARF compound 42 athrombin-K co-Rax compound 42 rodex CHEBI:68563 PMID:30178075 MIO:02641 P2Y12 receptors are present on blood platelets. These receptors are responsible for platelet aggregation and clotting. Clopidogrel, prasugrel, ticagrelor, ticlopidine, and cangrelor are P2Y12 receptor inhibitors and can be used as antiplatelets. Cangrelor is a newer agent which is administered via the intravenous route. [url:https://pubmed.ncbi.nlm.nih.gov/30178075/] P2Y12 inhibitor ADP receptor subtype P2Y12 antagonist ADP receptor subtype P2Y12 antagonists P2Y12 antagonist P2Y12 antagonists P2Y12 inhibitors P2Y12 receptor antagonist P2Y12 receptor antagonists purinergic receptor subtype P2Y12 antagonist purinergic receptor subtype P2Y12 antagonists NCIT:C76128 UMLS:C0288672 MIO:02642 A Fab fragment of the chimeric monoclonal antibody 7E3 and inhibitor of the glycoprotein (GP) IIb/IIIa receptor, that blocks platelet aggregation. Abciximab binds to the GP IIb/IIIa receptor on the platelet membrane, which inhibits the binding of fibrinogen to the GP IIb/IIIa receptor. This prevents both platelet aggregation and thrombus formation. [url:http://purl.obolibrary.org/obo/NCIT_C76128] abciximab ReoPro chimeric 7E3 fab NCIT:C170261 MIO:02643 orbofiban orbofiban CHEBI:47426 NCIT:C515 UMLS:C0016860 MIO:02644 A sulfamoylanthranilic acid derivative, also known as frusemide, and potent loop diuretic. Furosemide is widely used to treat hypertension and edema. This agent is highly bound to albumin and is largely excreted unchanged in the urine. [url:http://purl.obolibrary.org/obo/NCIT_C515] furosemide FRS LB-502 SK-Furosemide lasix NCIT:C840 MIO:02645 Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early puberty in boys, acne and excessive hair growth in women, and as a part of transgender hormone therapy in transgender women. Spironolactone is taken by mouth. [url:https://en.wikipedia.org/wiki/Spironolactone] spironolactone 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate SC 9420 SPL acetate aldactone gamma lactone NCIT:C2356 UMLS:C0280004 MIO:02646 Nonnarcotic agents that relieve pain and reduce fever. [url:http://purl.obolibrary.org/obo/NCIT_C2356] analgesic and antipyretic antipyretic and analgesic NCIT:C48149 UMLS:C0001644 MIO:02647 Beta adrenergic agonists or beta agonists are medications that relax muscles of the airways, causing widening of the airways and resulting in easier breathing. [url:https://en.wikipedia.org/wiki/Beta-adrenergic_agonist] beta-adrenergic agonist Beta-adrenoceptor agonist Beta-adrenoceptor agonists beta agonist beta agonists beta-adrenergic agonists NCIT:C61439 UMLS:C0083381 MIO:02648 An oxicam derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Unlike traditional nonselective NSAIDs, meloxicam preferentially inhibits the activity of cyclo-oxygenase II (COX-II), resulting in a decreased conversion of arachidonic acid into prostaglandin precursors. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of meloxicam. [url:http://purl.obolibrary.org/obo/NCIT_C61439] meloxicam 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide mobec mobic mobicox movalis movatec CHEBI:35530 NCIT:C29576 UMLS:C0001645 MIO:02649 Natural or synthetic beta adrenergic antagonists selectively or non-selectively blocking or diminishing physiologic beta-adrenergic agonist actions on the sympathetic system. This group of antagonists are generally used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. [url:http://purl.obolibrary.org/obo/NCIT_C29576] beta-adrenergic antagonist beta blocker beta blockers beta-blockers beta-blocking therapy β-blocker β-blockers CHEBI:6343 NCIT:C29146 MIO:02650 A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects. [url:http://purl.obolibrary.org/obo/NCIT_C29146] labetalol NCIT:C32958 MIO:02651 Any artery arising from the left coronary artery. [url:http://purl.obolibrary.org/obo/NCIT_C32958] left coronary artery branch branch of left coronary artery left coronary artery branch NCIT:C12875 MIO:02652 A coronary artery that originates above the right coronary cusp and supplies blood predominantly to the right side of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C12875] right coronary artery coronary artery, right right coronary artery NCIT:C102285 MIO:02653 The arteries that arise at the junction of the proximal and mid-right coronary artery conduit segments. [url:http://purl.obolibrary.org/obo/NCIT_C102285] acute marginal artery acute marginal artery acute marginal artery segment(s) amarg NCIT:C102296 MIO:02654 The section of the right coronary artery distal to the origin of the acute marginal artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102296] distal right coronary artery conduit distal right coronary artery conduit distal right coronary artery conduit segment drca NCIT:C102300 MIO:02655 In an individual with a right-dominant heart, this is the first branch that arises from the right coronary artery distal to the right posterior descending artery, when counted from proximal to distal. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102300] first right posterolateral artery 1st rpl first right posterolateral artery first right posterolateral artery segment NCIT:C12872 SNOMED:50018008 MIO:02656 A coronary artery that arises from the aorta and bifurcates into the left anterior descending artery and the left circumflex artery. [url:http://purl.obolibrary.org/obo/NCIT_C12872] left coronary artery coronary artery, left left coronary artery left coronary artery structure left main coronary artery left main coronary artery segment lm NCIT:C116178 MIO:02657 The second posterolateral branch originating from the posterior atrioventricular left circumflex artery in left dominant and mixed circulations. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC116178] left posterior descending artery left posterior descending artery NCIT:C102329 MIO:02658 The section of the right coronary artery between the right ventricular artery and the acute marginal artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102329] mid-right coronary artery conduit mid-right coronary artery mid-right coronary artery conduit mid-right coronary artery conduit segment mrca NCIT:C116170 MIO:02659 In an individual with a right-dominant heart, the arterial branch that arises from the distal right coronary artery in the posterior atrioventricular groove after the origin of the right posterior descending artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC116170] posterolateral coronary artery posterolateral coronary artery posterolateral segmental artery NCIT:C102337 MIO:02660 The section of the right coronary artery proximal to the origin of the right ventricular artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102337] proximal right coronary artery conduit prca proximal right coronary artery conduit proximal right coronary artery conduit segment NCIT:C102342 MIO:02661 In an individual with a right-dominant heart, the arterial branch that arises from the distal right coronary artery between the acute marginal artery and the first right posterolateral segment. It supplies the inferior apex of the heart. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102342] right coronary artery and its branches right coronary artery and its branches right coronary artery, right posterior descending, right posteriolateral and acute marginal branches right posterior atrioventricular artery right posterior atrioventricular artery segment right posterior descending artery right posterior descending artery segment rpav rpda NCIT:C102344 MIO:02662 The second artery arising from the left anterior descending (LAD) artery that supplies the anterolateral wall, when counted from proximal to distal. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102344] second diagonal branch artery 2nd diag second diagonal branch artery second diagonal branch artery segment NCIT:C102345 MIO:02663 In an individual with a left-dominant heart, this is the second branch that arises from the circumflex artery atrioventricular groove continuation when counted from proximal to distal. It supplies the posterolateral wall. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102345] second left posterolateral branch artery 2nd lpl second left posterolateral branch artery second left posterolateral branch artery segment NCIT:C102346 MIO:02664 The second artery arising from the left circumflex artery that supplies the lateral wall, when counted from proximal to distal. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102346] second obtuse marginal branch artery 2nd om second left marginal artery second obtuse marginal branch artery second obtuse marginal branch artery segment NCIT:C102347 MIO:02665 In an individual with a right-dominant heart, this is the second branch that arises from the right coronary artery distal to the right posterior descending artery, when counted from proximal to distal. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102347] second right posterolateral artery 2nd rpl second right posterolateral artery second right posterolateral artery segment NCIT:C102351 MIO:02666 The third artery arising from the left circumflex artery that supplies the lateral wall, when counted from proximal to distal. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102351] third obtuse marginal branch artery 3rd om third left marginal artery third obtuse marginal branch artery third obtuse marginal branch artery segment NCIT:C102352 MIO:02667 In an individual with a left-dominant heart, this is the third branch that arises from the circumflex artery atrioventricular groove continuation when counted from proximal to distal. It supplies the posterolateral wall. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102352] third posterolateral descending artery 3rd lpl third posterolateral descending artery third posterolateral descending artery segment NCIT:C102353 MIO:02668 In an individual with a right-dominant heart, this is the third branch that arises from the right coronary artery distal to the right posterior descending artery, when counted from proximal to distal. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102353] third right posterolateral artery 3rd rpl third right posterolateral artery third right posterolateral artery segment PMID:15286927 MIO:02669 The Sclarovsky-Birnbaum Ischemia Grading System based on the relation between the acute appearances of the T wave, the ST segment, and the QRS complex was considered as a means of enhanced ECG analysis in this group of patients. [url:https://pubmed.ncbi.nlm.nih.gov/15286927/] Sclarovsky-Birnbaum Ischemia Grading System SB-IG-score Sclarovsky-Birnbaum Ischemia Grade Sclarovsky-Birnbaum Severity of Ischemia Sclarovsky-Birnbaum severity grades of ischemia Sclarovsky-Birnbaum's Grades of Ischemia Score electrocardiographic Sclarovsky-Birnbaum ischemia grading system MP:0010516 MIO:02670 absence of the downward deflection in the ECG occurring after the PR interval that represents depolarization of the interventricular septum [url:http://purl.obolibrary.org/obo/MP_0010516] absent Q wave absence of Q wave absence of abnormal Q waves MIO:02671 prolonged corrected QT interval PMID:3788768 SNOMED:705011000 MIO:02672 ST segment depression in leads V1-5. [url:http://snomed.info/id/705011000] anterior ST segment depression ST depression in anterior leads ST segment depression in anterior leads STD in anterior leads anterior S-T segment depression anterior ST depression anterior STD SNOMED:704997005 MIO:02673 ST segment depression in leads II and/or III and/or aVF. [url:http://snomed.info/id/704997005] inferior ST segment depression ST segment depression in inferior leads inferior ST depression inferior STD PMID:21251135 MIO:02674 ST segment depression in leads V5-6 or I, aVL. lateral ST segment depression lateral ST depression lateral STD SNOMED:704998000 MIO:02675 ST segment depression seen in multiple regions, including anterior, lateral and inferior. [url:http://snomed.info/id/704998000] diffuse ST segment depression diffuse ST depression widespread ST depression widespread ST segment depression PMID:11431656 MIO:02676 ST segment depression in lead aVR ST depression in lead aVR STD in lead aVR PMID:17262766 MIO:02677 ST segment depression in lead V4R ST depression in lead V4R STD in lead V4R SNOMED:705008001 MIO:02678 ST segment elevation in precordial leads [url:http://snomed.info/id/705008001] anterior ST segment elevation ST segment elevation in anterior leads STE in anterior leads SNOMED:705007006 MIO:02679 ST segment elevation in leads II and/or III and/or aVF. [url:http://snomed.info/id/705007006] inferior ST segment elevation ST segment elevation in inferior leads STE in inferior leads SNOMED:705006002 MIO:02680 ST segment elevation in lead I and/or precordial leads V5-8 and/or aVL. [url:http://snomed.info/id/705006002] lateral ST segment elevation ST elevation in lateral leads ST segment elevation in lateral leads STE in lateral leads lateral STE PMID:10781353 MIO:02681 stress-induced ST segment elevation stress-induced ST elevation NCIT:C62159 MIO:02682 The minimum elevation of the ST segment, obtained from a set of measurements of the elevation of the ST segment. [url:http://purl.obolibrary.org/obo/NCIT_C62159] minimum ST segment elevation STELMIN minimal ST-segment elevation minimal STE summary (Min) ST elevation SNOMED:705010004 MIO:02683 posterior ST segment elevation ST elevation in posterior leads ST segment elevation in posterior leads STE in posterior leads PMID:25884447 PMID:31770667 MIO:02684 ST segment elevation in lead aVR ST elevation in aVR STE in lead aVR aVR-STE SNOMED:438605009 MIO:02685 Microvolt T wave alternans is a variant of T wave alternans that detects T wave alternans signals as small as one-millionth of a volt. Microvolt T wave alternans is defined as an alternation in the morphology of the T wave in an every other beat or AB-AB pattern. It has long been associated with ventricular arrhythmias and sudden death. First recognized nearly a century ago, visually discernible alternans were linked to the rapid onset of ventricular tachyarrhythmias. [url:https://en.wikipedia.org/wiki/T_wave_alternansMicrovolt_T_wave_Alternans_(MTWA)] microvolt T wave alternans MTWA EFO:1000882 NCIT:C80427 MIO:02686 Narrowing of the coronary artery lumen diameter. [url:http://purl.obolibrary.org/obo/NCIT_C80427] coronary artery stenosis coronary stenosis lesion stenosis of coronary artery stenosed coronary artery NCIT:C35505 MIO:02687 Atherosclerosis of the coronary vasculature. [url:http://purl.obolibrary.org/obo/NCIT_C35505] coronary atherosclerosis coronary atherosclerosis disease coronary atherosclerotic burden OAE:0002482 SNOMED:63739005 MIO:02688 a cardiac disorder AE which causes a partial or complete blockage of the coronary artery which can lead to heart attack. [url:http://purl.obolibrary.org/obo/OAE_0002482] coronary occlusion coronary artery obstruction coronary artery occluded coronary artery occlusion MIO:02689 Multivessel disease was defined as the presence of >/= 2 major epicardial coronary arteries or their major branches with stenosis of at least 70%, assessed during initial coronary angiography. multivessel coronary artery disease MCLs MVCAD MVD Multiple vessel lesions multi-vessel disease multiple complex lesions multivessel coronary disease multivessel disease polyvascular disease two or three vessels stenosis EFO:0004723 MIO:02690 Calcification of the coronary artery, used as a measure of coronary atherosclerosis, a risk factor for myocardial infarction. [url:http://www.ebi.ac.uk/efo/EFO_0004723] coronary artery calcification NCIT:C168177 MIO:02691 Diffuse dilation of a coronary artery segment. [url:http://purl.obolibrary.org/obo/NCIT_C168177] coronary artery ectasia CAE OAE:0000844 SNOMED:29899005 MIO:02692 a coronary artery disorder AE that has an outcome of an blockage in the coronary artery [url:http://purl.obolibrary.org/obo/OAE_0000844] coronary artery embolism coronary embolism coronary embolus NCIT:C99997 MIO:02693 There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in one coronary artery. [url:http://purl.obolibrary.org/obo/NCIT_C99997] one vessel coronary disease 1-vessel disease 1VD one vessel disease single vessel disease single-vessel disease PMID:31601367 MIO:02694 Premature CAD, defined as the occurrence of symptomatic obstructive coronary atherothrombotic lesions before age 45 years, has been described in a few registries of limited size and restricted to the description of the patients baseline characteristics in a retrospective approach. [url:https://pubmed.ncbi.nlm.nih.gov/31601367/] premature coronary artery disease premature CAD premature CHD premature coronary heart disease NCIT:C34830 MIO:02695 A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive. [url:http://purl.obolibrary.org/obo/NCIT_C34830] cardiomyopathy cardiomyopathies SNOMED:233928007 MIO:02696 myocardial dysfunction myocardial depression EFO:1001375 MIO:02697 A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction). [url:http://www.ebi.ac.uk/efo/EFO_1001375] myocardial ischemia ischemic disease of myocardium myocardial ischaemia myocardial ischemia myocardium ischemic disease MONDO:0004876 OMIT:0017989 MIO:02698 Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity. [ MESH:D017682 ] [url:http://purl.obolibrary.org/obo/MONDO_0004876] myocardial stunning NCIT:C50625 MIO:02699 A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries, to obstruction by a thrombus, or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction). [url:http://purl.obolibrary.org/obo/NCIT_C50625] ischemic heart disease IHD ischaemic heart disease ischemic heart disease SNOMED:417094009 MIO:02700 valvular sclerosis EFO:0002503 HP:0001640 NCIT:C61453 MIO:02701 Abnormal enlargement of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C61453] cardiomegaly cardiac hypertrophy enlarged heart heart hypertrophy increased heart size NCIT:C95834 MIO:02702 A heart disease that is present at birth. Representative examples include atrial septal defect, ventricular septal defect, tetralogy of Fallot, and patent foramen ovale. [url:http://purl.obolibrary.org/obo/NCIT_C95834] congenital heart disease NCIT:C78446 MIO:02703 A heart disorder characterized by a defect in mitral valve structure or function. [url:http://purl.obolibrary.org/obo/NCIT_C78446] mitral valve disorder mitral valve disease DOID:520 EFO:0005775 MESH:D001018 NCIT:C101253 SNOMED:47040006 UMLS:C0003493 MIO:02704 An artery disease that is characterized by degeneration of the cells composing the aortic wall. [url:http://purl.obolibrary.org/obo/DOID_520] aortic disease aorta disease aorta disease or disorder aortic disorder aortic valve disease aortic valve disease or disorder aortic valve disorder disease of aorta disease of aortic valve disease or disorder of aorta disease or disorder of aortic valve disorder of aortic valve disorder of the aorta MONDO:0002277 MIO:02705 A vascular disorder characterized by thickening and hardening of the walls of the arteries. [url:http://purl.obolibrary.org/obo/MONDO_0002277] arteriosclerosis arterial sclerosis arteriosclerosis disorder arteriosclerotic cardiovascular disease arteriosclerotic vascular disease cardiovascular arteriosclerosis vascular sclerosis DOID:0050830 MIO:02706 An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs. [url:http://purl.obolibrary.org/obo/DOID_0050830] peripheral artery disease peripheral arterial stenosis NCIT:C28195 MIO:02707 Occlusion of the lumen of a vessel by a thrombus that has migrated from a distal site via the blood stream. [url:http://purl.obolibrary.org/obo/NCIT_C28195] thromboembolism thromboembolic event PMID:21239074 MIO:02708 The concomitant presence of MVO in the necrotic myocardium is generated by an interaction of multiple factors, including embolization of thrombus and plaque, endothelial dysfunction, inflammation, myocardial edema and microvascular dysfunction after AMI. [url:https://pubmed.ncbi.nlm.nih.gov/21239074/] microvascular obstruction MVO PMID:30153967 MIO:02709 The term myocardial injury should be used when there is evidence of elevated cardiac troponin values (cTn) with at least one value above the 99th percentile upper reference limit (URL). The myocardial injury is considered acute if there is a rise and/or fall of cTn values. [url:https://pubmed.ncbi.nlm.nih.gov/30153967/] acute myocardial injury PMID:30580786 MIO:02710 Cardiac procedural myocardial injury is arbitrarily defined by increases of cTn values (>99th percentile URL) in patients with normal baseline values (≤99th percentile URL) or a rise of cTn values >20% of the baseline value when it is above the 99th percentile URL but it is stable or falling. [url:https://pubmed.ncbi.nlm.nih.gov/30580786/] cardiac procedural myocardial injury procedural myocardial injury PMID:30153967 MIO:02711 The term myocardial injury should be used when there is evidence of elevated cardiac troponin values (cTn) with at least one value above the 99th percentile upper reference limit (URL). The myocardial injury is considered chronic if there is a stable of cTn values. chronic myocardial injury EFO:0002687 MIO:02712 Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (reperfusion), including swelling; hemorrhage; necrosis; and damage from free radicals. The most common instance is myocardial reperfusion injury. [url:http://www.ebi.ac.uk/efo/EFO_0002687] ischemia reperfusion injury ischaemia reperfusion injury ischemia injury ischemia-reperfusion injury ischemia/reperfusion injury myocardial ischemia-reperfusion injury myocardial ischemic injury myocardial reperfusion injury DOID:6713 EFO:0000712 MESH:D002561 NCIT:C2938 PMID:22279115 PMID:32829713 PMID:9034940 SNOMED:266312006 UMLS:C0007820 MIO:02713 This is a group of brain dysfunctions related to disease of the blood vessels supplying the brain. This includes “stroke”, which includes the following entities - . Intracerebral haemorrhage; Subarachnoid haemorrhage; cerebral ischemic stroke, and Stroke not known if ischaemic or haemorrhagic. [url:http://id.who.int/icd/entity/843843448] cerebrovascular disease CVA cerebrovascular disorder cerebrovascular disorders NCIT:C84496 PMID:22537796 UMLS:C1704436 MIO:02714 A disorder of the arteries supplying the upper and lower extremity and the visceral organs. This includes the mesenteric arteries, the renal arteries and the aorta and excludes cerebrovascular arterial disease. Patients experience cramping and pain usually in the calves and thighs while walking. The symptoms subside with rest. [url:http://purl.obolibrary.org/obo/NCIT_C84496] peripheral arterial disorder PAD peripheral arterial disease peripheral arterial diseases peripheral arterial disorders EFO:0000384 MIO:02715 A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement. [url:http://www.ebi.ac.uk/efo/EFO_0000384] Crohn's disease Crohn disease Crohn's disease of colon granulomatous colitis ileocolitis pediatric Crohn's disease regional enteritis NCIT:C2952 MIO:02716 An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage. [url:http://purl.obolibrary.org/obo/NCIT_C2952] ulcerative colitis colitis ulcerative NCIT:C3354 MIO:02717 Infection with the respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, which is characterized by the formation of syncytia in tissue culture. It causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children. [url:http://purl.obolibrary.org/obo/NCIT_C3354] respiratory syncytial virus infection RSV infection GSSO:000523 MIO:02718 human immunodeficiency virus 1 infection [url:http://purl.obolibrary.org/obo/GSSO_000523] HIV-1 infection HP:0003774 MIO:02719 A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine, greater than 3 months. [url:http://purl.obolibrary.org/obo/HP_0003774] end stage kidney disease ESKD ESRD end stage renal disease end stage renal disease (ESRD) end stage renal failure end-stage renal disease end-stage renal failure stage 5 chronic kidney disease NCIT:C37967 MIO:02720 A finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen. Abnormally high level of cholesterol in the blood. [url:http://purl.obolibrary.org/obo/NCIT_C37967] hypercholesterolemia cholesterol high high cholesterol hypercholesterolaemia HP:0002155 MIO:02721 An abnormal increase in the level of triglycerides in the blood. [url:http://purl.obolibrary.org/obo/HP_0002155] hypertriglyceridemia increased circulating Tg levels increased plasma Tg levels increased plasma triglycerides increased serum triglycerides increased triglycerides HP:0040270 MP:0005291 UMLS:C0151671 MIO:02722 An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral or intravenous administration of glucose. [url:http://purl.obolibrary.org/obo/HP_0040270] impaired glucose tolerance IGT decreased glucose tolerance glucose tolerance decreased NCIT:C3389 PMID:20031840 UMLS:C0038436 MIO:02723 An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term. [url:http://purl.obolibrary.org/obo/NCIT_C3389] post-traumatic stress disorder PTSD combat neurosis post-traumatic stress disorder posttraumatic stress posttraumatic stress disorder NBO:0000528 MIO:02724 A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes. [url:http://en.wikipedia.org/wiki/Mood_disorder] cyclothymia NCIT:C34361 UMLS:C0001723 MIO:02725 The manifestation of psychotic symptoms, such as hallucinations or delusions, in the presence of a mood disorder. [url:http://purl.obolibrary.org/obo/NCIT_C34361] affective psychosis affective disorder SNOMED:64121000 MIO:02726 peptic ulcer with hemorrhage PUD bleeding peptic ulcer bleeding peptic ulcer disease bleeding peptic ulcer with haemorrhage HP:0011624 MIO:02727 A muscular ventricular septal defect located at the apex of the heart. [ DDD:dbrown ] [url:http://purl.obolibrary.org/obo/HP_0011624] apical muscular ventricular septal defect apical VSD NCIT:C102654 SNOMED:297160003 MIO:02728 A bulge or ballooning in the wall of the left ventricle of the heart. [url:http://purl.obolibrary.org/obo/NCIT_C102654] left ventricular aneurysm LV aneurysm LVA PMID:29075588 PMID:30943895 PMID:31256958 MIO:02729 The free wall rupture site is in the inferolateral (posterior) wall segment (43%), lateral wall (28%), and then the apical wall (24%) followed by other segments at equal frequency. Left ventricular free wall rupture (LVFWR) is a grave complication of acute myocardial infarction (MI). [url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656223/] left ventricular free wall rupture rupture of the free wall of the left ventricle PMID:21298231 MIO:02730 Right ventricular (RV) rupture is a rare and dangerous complication of acute myocardial infarction (MI). [url:https://pubmed.ncbi.nlm.nih.gov/21298231/] right ventricular free wall rupture PMID:34126755 SNOMED:373116009 MIO:02731 acute mitral regurgitation acute mitral valve regurgitation SNOMED:233861004 MIO:02732 functional mitral regurgitation PMID:20890048 MIO:02733 Ischemic mitral regurgitation (IMR) is mitral incompetence resulting from coronary artery disease in the absence of intrinsic valve lesions, [url:https://pubmed.ncbi.nlm.nih.gov/20890048/] ischemic mitral regurgitation IMR ischeamic mitral regurgitation PMID:30571511 MIO:02734 Acute stent thrombosis is defined as the occurrence of thrombosis within 24 hours after stent implantation. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] acute stent thrombosis acute ST PMID:30571511 MIO:02735 Acute stent thrombosis is defined as the occurrence of thrombosis between 24 hours and 30 days after stent implantation. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] subacute stent thrombosis SST subacute ST subacute thrombosis MIO:02736 Very late stent thrombosis (VLST) is a rare but serious complication following percutaneous coronary intervention (PCI). Very late stent thrombosis was defined according to the 2007 definition of Academic Research Consortium stent thrombosis criteria: stent thrombosis that occurred more than 1 year after coronary stent implantation and clearly confirmed by coronary angiography. very late stent thrombosis VLST NCIT:C49343 MIO:02737 A blood clot in a deep vein, predominantly in the lower extremity, but may include the pelvis or upper extremity. [url:http://purl.obolibrary.org/obo/NCIT_C49343] deep vein thrombosis DVT deep vein thrombosis (DVT) NCIT:C55010 MIO:02738 Grade II diastolic dysfunction is called "pseudonormal filling dynamics". This is considered moderate diastolic dysfunction and is associated with elevated left atrial filling pressures. These patients more commonly have symptoms of heart failure, and many have left atrial enlargement due to the elevated pressures in the left heart. [url:https://en.wikipedia.org/wiki/Heart_failure_with_preserved_ejection_fraction] grade 2 left ventricular diastolic dysfunction grade II diastolic dysfunction pseudonormal filling pseudonormal filling dynamics pseudonormal pattern NCIT:C164223 MIO:02739 A person who uses a vaping device at least once every day. [url:http://purl.obolibrary.org/obo/NCIT_C164223] current daily vaper daily e-cigarette use daily vaper every day vaper MIO:02740 current some day vaper some days e-cigarette use SNOMED:161625008 MIO:02741 history of cardiac surgery HP:0011706 NCIT:C111119 SNOMED:195042002 UMLS:C0264906 MIO:02742 An intermittent atrioventricular block with failure of some atrial impulses to conduct to the ventricles, i.e., some but not all atrial impulses are conducted through the atrioventricular node and trigger ventricular contraction. [url:http://purl.obolibrary.org/obo/HP_0011706] second degree atrioventricular block AV block second degree incomplete atrioventricular block, second degree second degree heart block DOID:0050823 HP:0001709 ICD11:BC63.2Z NCIT:C50501 SNOMED:27885002 UMLS:C0151517 MIO:02743 Third-degree atrioventricular (AV) block (also referred to as complete heart block) is the complete dissociation of the atria and the ventricles. Third-degree AV block exists when more P waves than QRS complexes exist and no relationship (no conduction) exists between them. [url:http://purl.obolibrary.org/obo/HP_0001709] third degree atrioventricular block complete AV block complete atrioventricular block complete heart block third degree heart block third-degree heart block HP:0011713 ICD11:BC63.4 MSH:D002037 PMID:30341846 SNOMED:63467002 UMLS:C0023211 MIO:02744 Disorder of the atrioventricular conduction system in which the QRS duration is greater than or equal to 120 ms in adults, greater than 100 ms in children 4 to 16 years of age, and greater than 90 ms in children less than 4 years of age; there is a QS or rS pattern in lead V1 and a wide slurred R wave in leads I and V6.[url:http://id.who.int/icd/entity/1553795531] A conduction block of the left branch of the bundle of His. This manifests as a generalized disturbance of QRS morphology on EKG. [url:http://purl.obolibrary.org/obo/HP_0011713] left bundle branch block LBBB HP:0011712 ICD11:BC63.3 MSH:D002037 NCIT:C62270 PMID:30341846 SNOMED:59118001 UMLS:C0085615 MIO:02745 Disorder of the atrioventricular conduction system characterised by prolonged QRS duration (greater than or equal to 120 ms in adults, greater than 100 ms in children ages 4 to 16 years, and greater than 90 ms in children less than 4 years of age), rsr, rsR, or rSR in leads V1 or V2, S wave of greater duration than R wave (or greater than 40 ms in leads I and V6 in adults) [url:http://id.who.int/icd/entity/1434611572] right bundle branch block NCIT:C80391 MIO:02746 A disorder characterized by an electrocardiographic finding of episodic atrial fibrillation with abrupt onset and termination. [url:http://purl.obolibrary.org/obo/NCIT_C80391] paroxysmal atrial fibrillation PAF paroxymsal AFib paroxysmal AF CVDO:0000238 HP:0004754 MIO:02747 Atrial fibrillation (AF) that cannot be successfully terminated by cardioversion, and longstanding (more than 1 year) AF, where cardioversion is not indicated or has not been attempted, is termed permanent. [url:http://purl.obolibrary.org/obo/HP_0004754] permanent atrial fibrillation permanent AF PMID:25903836 MIO:02748 Silent atrial fibrillation (AF) is an asymptomatic atrial arrhythmia that can be diagnosed by chance during a systematic electrocardiogram, an external Holter, or from implanted cardiac devices. [url:https://pubmed.ncbi.nlm.nih.gov/32125174/] silent atrial fibrillation asymptomatic AF asymptomatic atrial fibrillation slient AF PMID:2754119 MIO:02749 sustained monomorphic ventricular tachycardia PMID:11182180 MIO:02750 The location of the radiating chest pain is in the upper abdomen. radiating chest pain to the upper abdomen epigastralgia epigastric discomfort epigastric pain pain in the upper abdomen radiating chest pain in upper abdomen upper abdominal pain NCIT:C167484 PMID:11182180 MIO:02751 The location of the radiating chest pain is in the left arm. [url:http://purl.obolibrary.org/obo/NCIT_C167484&ns=ncit] radiating chest pain to the left arm left arm pain pain in left arm radiating chest pain in left arm MIO:02752 The location of the radiating chest pain is in the right arm. radiating chest pain to the right arm pain in right arm radiating chest pain in right arm right arm pain PMID:11182180 MIO:02753 The location of the radiating chest pain is in the jaw. radiating chest pain to the jaw jaw pain mandibular pain radiating chest pain in jaw temporomandibular joint pain PMID:11182180 MIO:02754 The location of the radiating chest pain is in the left shoulder. radiating chest pain to the left shoulder left shoulder pain radiating chest pain in left shoulder MIO:02755 The location of the radiating chest pain is in the right shoulder. radiating chest pain to the right shoulder radiating chest pain in right shoulder right shoulder pain MIO:02756 cardiac electrical biomarker NCIT:C102264 PMID:33620437 MIO:02757 A measurement of time from the start of the thrombin generation test to the point where a predetermined amount of thrombin is generated. [url:http://purl.obolibrary.org/obo/NCIT_C102264] endogenous thrombin potential lag time ETP lag time ETPLT NCIT:C102270 PMID:33620437 UMLS:C3640660 MIO:02758 A relative (ratio or percentage) measurement of the time it takes to generate the maximum concentration of thrombin. [url:http://purl.obolibrary.org/obo/NCIT_C102270] endogenous thrombin potential time to peak ETP time to peak ETPTP NCIT:C77271 UMLS:C2697846 MIO:02759 A classification of myocardial infarction characterized by rales over more than 50% of the lung fields. [url:http://purl.obolibrary.org/obo/NCIT_C77271] Killip class III Killip 3 Killip III Killip class 3 NCIT:C77272 UMLS:C2697847 MIO:02760 A classification of myocardial infarction characterized by cardiogenic shock; an event with systolic BP less than 90 mmHg for greater than 30 minutes, not responsive to fluid resuscitation alone, and felt to be secondary to cardiac dysfunction. Associated signs of hypoperfusion (cool and clammy skin, oliguria, or altered sensorium) or a cardiac index of less than 2.2 L/min/m2 are present. This includes when the systolic BP increases to greater than 90 mmHg in response to inotropic agents in less than 1 hour.) [url:http://purl.obolibrary.org/obo/NCIT_C77272] Killip class IV Killip IV Killip class 4 MIO:02761 The motion of a segment of the left ventricle during the cardiac cycle. regional left ventricular wall motion NCIT:C168192 MIO:02762 A graded test to measure an individual's heart rate and oxygen intake while undergoing strenuous physical exercise; most often assessed on a treadmill. [url:http://purl.obolibrary.org/obo/NCIT_C168192] exercise cardiac stress test ECST exercise stress test SNOMED:424225000 MIO:02763 dobutamine stress test cardiovascular stress test using the dobutamine stress test protocol dobutamine stress testing NCIT:C172564 MIO:02764 An exercise testing method that continuously measures respiratory volume and frequency, oxygen intake, carbon-dioxide output, and heart rate during ergometer exercise to assess integrative cardiopulmonary, musculoskeletal, and metabolic response to physical stress. [url:http://purl.obolibrary.org/obo/NCIT_C172564] ergospirometry Spiroergometry NCIT:C62085 MIO:02765 Measurements or calculations on measurements obtained from electrocardiographic tracings. [url:http://purl.obolibrary.org/obo/NCIT_C41328] ECG measurement EKG measurement SNOMED:29303009 MIO:02766 electrocardiographic procedure MIO:02767 Tissue Doppler echocardiography (TDE) is a medical ultrasound technology, specifically a form of echocardiography that measures the velocity of the heart muscle (myocardium) through the phases of one or more heartbeats by the Doppler effect (frequency shift) of the reflected ultrasound. The technique is the same as for flow Doppler echocardiography measuring flow velocities. Tissue signals, however, have higher amplitude and lower velocities, and the signals are extracted by using different filter and gain settings. The terms tissue Doppler imaging (TDI) and tissue velocity imaging (TVI) are usually synonymous with TDE because echocardiography is the main use of tissue Doppler. [url:https://en.wikipedia.org/wiki/Tissue_Doppler_echocardiography] tissue doppler echocardiography SNOMED:816997000 MIO:02768 pharmacologic stress echocardiography echocardiography using pharmacologic stress agent SNOMED:433233004 MIO:02769 exercise stress echocardiography exercise echocardiography OMIT:0019586 MIO:02770 four-dimensional echocardiography 4-D echocardiography 4-dimensional echocardiography 4D echocardiography echocardiography, four-dimensional NCIT:C74760 MIO:02771 The determination of the amount of protein present in a urine sample. [url:http://purl.obolibrary.org/obo/NCIT_C74760] urine protein measurement CMO:0002570 NCIT:C129882 MIO:02772 Molecules created during the catabolism of catecholamine hormones. Increased concentrations of these metabolic products in plasma and urine may indicate the presence of hormone-producing pheochromocytomas or paragangliomas. [url:http://purl.obolibrary.org/obo/NCIT_C129882] urine catecholamine urine CA NCIT:C2302 MIO:02773 A hormone synthesized and secreted by the thyroid gland containing four iodine atoms and is converted to triiodothyronine (T3) in the body, influencing metabolism and organ function. [url:http://purl.obolibrary.org/obo/NCIT_C2302] thyroxine L-3,5,5'-tetraiodothyronine T4 thyroxin NCIT:C121328 MIO:02774 An antiphospholipid autoantibody that reacts with beta-2-glycoprotein 1, and a member of family of autoantibodies that cause antiphospholipid antibody syndrome and may be found in system lupus erythematosus. [url:http://purl.obolibrary.org/obo/NCIT_C121328] anti-beta-2 glycoprotein 1 antibody AAHA AB2GP Anti-B2GP1 anti-APOH anti-apolipoprotein H anti-apolipoprotein H antibody anti-beta-2 glycoprotein 1 antibody anti-beta-2 glycoprotein I antibody anti-beta2-glycoprotein I antibodies PMID:15978102 MIO:02775 antibody to endothelial protein C receptor antibodies against endothelial receptor of protein C autoantibodies against the endothelial receptor of protein C NCIT:C569 MIO:02776 The major immunoglobulin secreted during a primary immune response. IgM binds with low affinity but high avidity (multiple binding sites) because it not only occurs as monomers but also as pentamers and hexamers. [url:http://purl.obolibrary.org/obo/NCIT_C569] IgM immunoglobulin M NCIT:C81977 UMLS:C2825864 MIO:02777 The determination of the amount of antithrombin antigen present in a sample. [url:http://purl.obolibrary.org/obo/NCIT_C81977] antithrombin antigen ANTHRMAG antithrombin antithrombin III antithrombin III antigen antithrombin antigen GSSO:010096 MIO:02778 Increase or decrease of the number of copies of a chromosomal region. Sizes of copy number variations range from about 1 kilobase to several megabases. [url:http://purl.obolibrary.org/obo/GSSO_010096] copy number variation CNV copy-number variation MIO:02779 The ratio between the levels of free triiodothyronine and free thyroxine. free triiodothyronine/free thyroxine ratio free T3/free T4 ratio NCIT:C67038 MIO:02780 A fatty acid containing more than one double bond (C=C). The essential fatty acids omega-3 and omega-6 are polyunsaturated fatty acids (PUFAs) that contain 2 or more cis double bonds. Dietary intake of some PUFAs may have beneficial effects on blood pressure, serum lipds, and inflammation. Some PUFAs, such as omega-3 PUFAs, may have antineoplastic or chemopreventive activities. [url:http://purl.obolibrary.org/obo/NCIT_C67038] polyunsaturated fatty acid PUFA fatty acid, total polyunsaturat polyunsaturated fatty acids NCIT:C68440 MIO:02781 A class of dietary fatty acids containing at least one double bond in the trans formation. A type of fat that has certain chemical properties and is usually found in processed foods such as baked goods, snack foods, fried foods, shortening, margarine, and certain vegetable oils. Eating trans fat increases blood cholesterol levels and the risk of heart disease. [url:http://purl.obolibrary.org/obo/NCIT_C68440] trans fatty acid trans fat trans fatty acids CHEBI:28667 NCIT:C103344 MIO:02782 A thromboxane obtained by formal oxidation of the hemiacetal hydroxy function of thromboxane B2. [url:http://purl.obolibrary.org/obo/CHEBI_28667] 11-dehydro-thromboxane B2 (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxothromboxa-5,13-dien-1-oic acid 11-Dehydro-TXB2 CHEBI:27432 MIO:02783 A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect. [url:http://purl.obolibrary.org/obo/CHEBI_27432] alpha-linolenic acid (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid ALA NCIT:C68408 SNOMED:16546006 MIO:02784 Monounsaturated fatty acid with 16 carbons and the double bond in the cis formation at the 7th carbon from the methyl end. [url:http://purl.obolibrary.org/obo/NCIT_C68408] palmitoleic acid 9 cis-hexadecenoic acid 9-cis-hexadecenoic acid 9-hexadecenoic acid fatty acid 16:1 n-7 hexadec-9-enoic acid palmitoleic acid NCIT:C80200 SNOMED:259582002 MIO:02785 When circulating in the plasma (plasma fatty acids), not in their ester, fatty acids are known as non-esterified fatty acids (NEFAs) or free fatty acids (FFAs). FFAs are always bound to a transport protein, such as albumin. [url:https://en.wikipedia.org/wiki/Fatty_acidFree_fatty_acids] unesterified fatty acid FFA FFAu NEFA UFA free fatty acid free fatty acids free non-esterified fatty acids nonesterified fatty acids unbound free fatty acid unesterified fatty acid CHEBI:50404 MIO:02786 Cholesterol esters and free cholesterol which are contained in or bound to lipoproteins. [url:http://purl.obolibrary.org/obo/CHEBI_50404] lipoprotein cholesterol NCIT:C112325 SNOMED:259569005 MIO:02787 The determination of the amount of intermediate density lipoprotein present in a sample. [url:http://purl.obolibrary.org/obo/NCIT_C112325] intermediate density lipoprotein cholesterol IDL IDL cholesterol IDL-C intermediate density lipoprotein EFO:0010815 NCIT:C120655 MIO:02788 Remnant cholesterol, also known as remnant lipoprotein, is a very atherogenic lipoprotein composed primarily of very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL). [url:https://en.wikipedia.org/wiki/Remnant_cholesterol] remnant-like particle cholesterol RLP-C remnant cholesterol remnant lipoprotein remnant-like particles cholesterol remnant-like particles-cholesterol MIO:02789 The ratio between the levels of low-density lipoprotein cholesterol and total cholesterol. low-density lipoprotein cholesterol to total cholesterol ratio MIO:02790 The ratio between the levels of triglyceride and high-density lipoprotein cholesterol. triglyceride to high-density lipoprotein cholesterol ratio NCIT:C70619 MIO:02791 An IgM autoantibody directed against cardiolipin. It is associated with hemolytic anemia. [url:http://purl.obolibrary.org/obo/NCIT_C70619] anticardiolipin IgM antibody ACA IgM MIO:02792 The use of a single high-sensitivity cardiac troponin (hs-cTn) test concentration on presentation to the emergency department has been proposed for triage and early decision-making in patients with suspected acute coronary syndrome. high sensitivity cardiac troponin I high sensitivity troponin I high-sensitivity cardiac troponin I hs-cTnI hsTnI NCIT:C113810 MIO:02793 The use of a single high-sensitivity cardiac troponin (hs-cTn) test concentration on presentation to the emergency department has been proposed for triage and early decision-making in patients with suspected acute coronary syndrome. high sensitivity cardiac troponin T Trop-T HS high sensitivity troponin T high-sensitivity cardiac troponin T hs-cTnT hsTnT troponin-T HS MIO:02794 creatine kinase MM3 MIO:02795 The ratio between the levels of interleukin-10 and interleukin-6. interleukin-10/interleukin-6 ratio HP:0003074 MIO:02796 An increased concentration of glucose in the blood. [url:http://purl.obolibrary.org/obo/HP_0003074] hyperglycemia high blood glucose high blood sugar hyperglycaemia SNOMED:390951007 MIO:02797 Impaired fasting glucose is a type of prediabetes, in which a person's blood sugar levels during fasting are consistently above the normal range, but below the diagnostic cut-off for a formal diagnosis of diabetes mellitus. [url:https://en.wikipedia.org/wiki/Impaired_fasting_glucose] impaired fasting glucose IFG impaired fasting glycaemia impaired fasting glycemia HP:0000855 MIO:02798 Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels. [url:http://purl.obolibrary.org/obo/HP_0000855] insulin resistance body fails to respond to insulin DOID:409 EFO:0001421 NCIT:C3196 PMID:22279115 SNOMED:235856003 MIO:02799 A disease involving the liver. [url:http://www.ebi.ac.uk/efo/EFO_0001421] liver disease disease of liver disease or disorder of liver disorder of liver hepatic disease hepatic disorder liver and intrahepatic bile duct disorder liver disease or disorder liver disorder antepartum EFO:0000278 MIO:02800 Inflammation of the pancreas. [url:http://www.ebi.ac.uk/efo/EFO_0000278] pancreatitis inflammation of pancreas pancreas inflammation pancreatitides NCIT:C34918 MIO:02801 An acute or chronic inflammatory process that affects the tissues that surround and support the teeth. [url:http://purl.obolibrary.org/obo/NCIT_C34918] periodontitis periodontitis disease OAE:0001460 OMIT:0016909 MIO:02802 a bone disorder AE that has an outcome of one or more teeth coming loose and falling out [url:http://purl.obolibrary.org/obo/OAE_0001460] tooth loss EFO:1000024 MIO:02803 Chronic form of sinusitis. [url:http://www.ebi.ac.uk/efo/EFO_1000024] chronic rhinosinusitis chronic sinusitis PMID:19695858 MIO:02804 Boiled coffee is prepared by heating a mixture of coarsely ground coffee and water to a boil, resulting in a high diterpene concentration. [url:https://pubmed.ncbi.nlm.nih.gov/19695858/] boiled coffee consumption consumption of boiled coffee SNOMED:275386008 MIO:02805 heavy coffee consumption (4 or more cups/day) excessive coffee drinker excessive coffee drinkers heavy coffee consumption heavy coffee drinker heavy coffee drinkers high coffee intake PMID:19695858 MIO:02806 Filtered coffee, the most common coffee in northern Sweden, is prepared by running boiling water through a filter containing finely ground roasted coffee beans. [url:https://pubmed.ncbi.nlm.nih.gov/19695858/] filtered coffee consumption consumption of filtered coffee PMID:16837823 MIO:02807 moderate consumption of coffee (2–3 cups/day) moderate coffee drinker moderate coffee drinkers moderate consumption of coffee PMID:16837823 MIO:02808 light/occasional intake of coffee (up to 1 cup/day) occasional coffee drinker light intake of coffee occasional coffee drinkers occasional intake of coffee SNOMED:226424004 MIO:02809 ghee intake SNOMED:226448008 MIO:02810 vegetable intake vegetable consumption vegetables consumption MIO:02811 fruit intake SNOMED:226439003 MIO:02812 Ham is pork from a leg cut that has been preserved by wet or dry curing, with or without smoking. As a processed meat, the term "ham" includes both whole cuts of meat and ones that have been mechanically formed.[url:http://purl.obolibrary.org/obo/FOODON_00002502] ham intake ham ham consumption ham food product NCIT:C20046 SNOMED:226427006 MIO:02813 A risk factor for colorectal, stomach, and pancreatic cancer. [url:http://purl.obolibrary.org/obo/NCIT_C20046] red meat intake red meat consumption NCIT:C68339 MIO:02814 A class of organic compound that is found in various foods, comprising an alkyl chain with a carboxylic acid end. Naturally occurring dietary fatty acids have a carbon backbone that ranges in length from 4 to 24 units.[url:http://purl.obolibrary.org/obo/NCIT_C68339] dietary fatty acid intake dietary fatty acid fatty acid fatty acid intake fatty acids NCIT:C68444 PMID:16684389 MIO:02815 A flavonoid with a positively charged oxygen in the pyran moiety that has 5 double bonds in the benzopyran group. [url:http://purl.obolibrary.org/obo/NCIT_C68444] anthocyanidin intake anthocyanidin anthocyanin anthocyanin consumption anthocyanin intake consumption of anthocyanin intake of anthocyanidins intake of anthocyanin intake of anthocyanins FOBI:040121 MIO:02816 flavan-3-ols intake flavan-3-ols NCIT:C68459 MIO:02817 A flavonoid typically with no double bond between C-2 and C-3, with a carbonyl (C=O) function at C-4, and without a hydroxyl group at C-3. [url:http://purl.obolibrary.org/obo/NCIT_C68459] flavanone intake flavanone flavanones NCIT:C68464 MIO:02818 A flavonoid typically with a double bond between C-2 and C-3, a carbonyl (C=O) function at C-4, and no hydroxyl group at C-3. [url:http://purl.obolibrary.org/obo/NCIT_C68464] flavone intake flavone NCIT:C68456 MIO:02819 A flavonoid typically with a double bond between C-2 and C-3, a carbonyl (C=O) function at C-4, and a hydroxyl group at C-3. [url:http://purl.obolibrary.org/obo/NCIT_C68456] flavonol intake flavonol NCIT:C599 MIO:02820 A class of polyphenolic compounds derived from the Fabaceae family with potential phytoestrogenic, cholesterol-reducing, chemotherapeutic and antioxidant activity. In isoflavones the phenyl group on the benzopyran ring is in position 3 relative to the oxygen of the ring. Most isoflavones for human consumption and that are currently studied are derived from soy beans. [url:http://purl.obolibrary.org/obo/NCIT_C599] isoflavone intake 3-phenylchromone isoflavone isoflavones MAXO:0000108 SNOMED:286614006 MIO:02821 Oral iron supplementation is an effective and well‐studied option to replenish iron stores. [url:http://purl.obolibrary.org/obo/MAXO_0000108] iron intake dietary supplementation of iron atomiron iron atomiron supplemental intake iron supplementation oral iron supplementation supplementation of iron atomiron MAXO:0001139 MIO:02822 Addition of calcium atomcalcium to a the diet for complete nutrition support. [url:http://purl.obolibrary.org/obo/MAXO_0001139] calcium intake calcium supplementation dietary supplementation of calcium atomcalcium supplementation of calcium atomcalcium supplementation with calcium NCIT:C68295 SNOMED:286617004 MIO:02823 Forms of the element zinc found in foods. [url:http://purl.obolibrary.org/obo/NCIT_C68295] zinc intake dietary dietary zinc NCIT:C68269 MIO:02824 Forms of the element mercury found in foods. [url:http://purl.obolibrary.org/obo/NCIT_C68269] dietary mercury intake Hg intake of mercury mercury mercury intake NCIT:C68287 SNOMED:267110002 MIO:02825 Forms of the element sodium found in foods.[url:http://purl.obolibrary.org/obo/NCIT_C68287] dietary sodium intake sodium sodium intake SNOMED:230123003 MIO:02826 phosphate intake NCIT:C68279 SNOMED:788479004 MIO:02827 Forms of the element potassium found in foods. [url:http://purl.obolibrary.org/obo/NCIT_C68279] potassium intake K dietary potassium potassium NCIT:C1550 SNOMED:226351000 MIO:02828 A vitamin that can dissolve in fats and oils. Fat-soluble vitamins are absorbed along with fats in the diet and can be stored in the body's fatty tissue. They come from plant and animal foods or dietary supplements. Vitamins A, D, E, and K are fat-soluble. Class of vitamins which are soluble in fat.[url:http://purl.obolibrary.org/obo/NCIT_C1550] fat soluble vitamin intake fat soluble vitamin NCIT:C1551 SNOMED:226350004 MIO:02829 A vitamin that can dissolve in water. Water-soluble vitamins are carried to the body's tissues but are not stored in the body. They are found in plant and animal foods or dietary supplements and must be taken in daily. Vitamin C and members of the vitamin B complex are water-soluble. Class of vitamins which are soluble in water.[url:http://purl.obolibrary.org/obo/NCIT_C1551] water soluble vitamin intake water soluble vitamin MAXO:0000107 MIO:02830 A dietary supplement containing all or most of the vitamins that may not be readily available in the diet. Vitamins may be classified according to their solubility either in lipids (vitamins A, D, E, K, F) or in water (vitamins C, B-complex). Present in minute amounts in various foods, vitamins are essential to maintaining normal metabolism and biochemical functions.[url:http://purl.obolibrary.org/obo/MAXO_0000107] Addition of multivitamin preparation to the diet for adequate and complete nutrition. [url:http://purl.obolibrary.org/obo/MAXO_0000107] multivitamin supplementation dietary supplementation of multivitamin preparation multivitamin multivitamin preparation supplemental intake multivitamin supplements supplementation of multivitamin preparation supplementation with multivitamin SNOMED:39545002 MIO:02831 low cholesterol-low saturated fat diet diet low in saturated fat and cholesterol low cholesterol, low saturated fat diet low cholesterol-low saturated fat diet low fat/low cholesterol diet low saturated fat and low cholesterol diet low-saturated fat, low-cholesterol diet MIO:02832 age 58 years or younger age </=58 years age <59 years age under 59 years age ≤58 years aged </=58 years aged <59 years aged under 59 years under 59 years of age under 59 years old MIO:02833 age above 50 years above 50 years of age age 51 years or older age >/=51 years age >50 years age of more than 50 age over 50 years age ≥51 years aged >50 years aged over 50 aged over 50 years at least 51 years of age at least 51 years old over 50 years of age over 50 years old MIO:02834 The ratio between T-peak to T-end interval and QT interval for premature ventricular complex. T-peak to T-end interval/QT interval ratio of premature ventricular complex PMID:23113242 PMID:31351997 PMID:32393179 MIO:02835 HF was taken as an indice of vagal activity.[url:https://pubmed.ncbi.nlm.nih.gov/32393179/] High frequency wave power is defined as the energy in the power spectrum between 0.15 and 0.40 Hz. [url:https://pubmed.ncbi.nlm.nih.gov/23113242/] high-frequency power HF high frequency high frequency spectral component high frequency wave power power in high frequency PMID:31351997 MIO:02836 The LF/HF ratio was taken as an index of the sympathovagal balance.[url:https://pubmed.ncbi.nlm.nih.gov/31351997/] low frequency to high frequency ratio LF/HF LF/HF ratio low frequency-to-high frequency ratio low to high frequency power ratio averaged for every 5 minute PMID:31351997 PMID:32393179 MIO:02837 LF was taken as an indice of sympathetic and vagal activity.[url:https://pubmed.ncbi.nlm.nih.gov/32393179/] Low frequency power is defined as the energy in the power spectrum between 0.04 and 0.15 Hz. [url:https://pubmed.ncbi.nlm.nih.gov/31351997/] low-frequency power LF low frequency low frequency spectral component low frequency wave power low-frequency component power in low frequency PMID:23113242 PMID:32393179 MIO:02838 Total spectral power in 0.003-0.400 Hz frequency band. [url:https://pubmed.ncbi.nlm.nih.gov/23113242/] total power of heart rate variability total power total spectral power PMID:15673380 MIO:02839 Ultra low frequency wave power is defined as the energy in the power spectrum between 1.15*10^-5 and 0.003 Hz. [url:https://pubmed.ncbi.nlm.nih.gov/15673380/] ultra low frequency power ULF Ultra low frequency wave power ultra low frequency PMID:32393179 PMID:32771785 MIO:02840 Very low frequency wave power is defined as the energy in the power spectrum between 0.0.1 and 0.04 Hz. [url:https://pubmed.ncbi.nlm.nih.gov/32771785/] very low frequency power VLF power in very low frequency very low frequency PMID:15673380 MIO:02841 Detrended fluctuation analysis provides a quantitative method for determining the degree to which a time series is random at the one extreme and correlated at the other. DFA1 ranges in value from 0.5 (random) to 1.5 (correlated), with normal values of just over 1.0. Decreased DFA1 (also called alpha 1) has been associated with adverse outcomes in cardiac patient populations.Only N-N intervals were used for this calculation. DFA1 can be considered a short-term non- linear measure. [url:https://pubmed.ncbi.nlm.nih.gov/15673380/] detrended fluctuation analysis alpha 1 index DFA(1) DFA1 detrended fluctuation analysis short-term fractal scaling exponent short-term fractal-like scaling exponent short-term scaling exponent alpha short-term scaling exponent alpha1 short‐term scaling exponent α1 PMID:21994495 PMID:27094219 MIO:02842 The non-Gaussianity index of HRV indicates the probability of volcanic heart rate deviations of departure from each standard deviation level, as a marker of sympathetic cardiac overdrive. [url:https://pubmed.ncbi.nlm.nih.gov/27094219/] non-Gaussianity index of heart rate variability non-Gaussianity index non-Gaussianity index (λ) non-Gaussianity index of HRV non-gaussianity of heart rate variability λ(25s) PMID:15673380 MIO:02843 Decreased power law slope has been shown to be a marker for increased risk of mortality post-MI.[url:https://pubmed.ncbi.nlm.nih.gov/15673380/] In normal sinus rhythm, spectral power, when measured over 2 4 hours, shows a progressive, virtually exponential in- crease in amplitude with decreasing frequency. This also can be plotted as the log of power versus the log of frequency, which transforms the exponential curve to a line whose slope can be measured. The power law slope is the slope of this line, measured between 10^-2 and 10^-4 Hz, and is a negative number. It is believe to reflect the degree to which the patterns of the heart rate time series are self-similar over a scale of minutes to hours. [url:https://pubmed.ncbi.nlm.nih.gov/15673380/] power law slope exponent beta power-law scaling power-law slope beta PMID:15673380 MIO:02844 The nonlinear index SD12 quantifies the shape of the Poincare plot, a figure in which each R-R interval is plotted against the previous one. 12 is the ratio of the lengths of the axes of an imaginary ellipse that has its center at the average R-R interval of the time series and is fitted to the Poincare plot. SD2 reflects intermediate-term variability. [url:https://pubmed.ncbi.nlm.nih.gov/15673380/] SD12 Poincare dimension SD1/SD2 SD1/SD2 ratio PMID:24886422 MIO:02845 Heart rate variability triangular indexwas defined as the total number of normal‐to‐normal (NN) intervals divided by the number of NN intervals in the modal bin. heart rate variability triangular index HRV triangular index HRVI triangle index triangle index of a geometric figure MIO:02846 mean normal-to-normal intervals average R-R intervals mean NN intervals mean N–N interval mean R-R intervals PMID:32393179 MIO:02847 pNN50 was taken as an indice of total variability.[url:https://pubmed.ncbi.nlm.nih.gov/32393179/] percetange of adjacent NN intervals differing by more than 50 milliseconds pNN50 percent of N-N intervals >50 msec different from the prior interval percent of adjacent normal R-R intervals with a difference ≥50 msec percentage of successive normal R-R intervals differing by more than 50 ms percentage of successive normal-to-normal R-R intervals that differ by > 50 ms PMID:23093257 PMID:3239317 MIO:02848 RMSSD was taken as an indice of vagal activity.[url:https://pubmed.ncbi.nlm.nih.gov/32393179/] RMSSD (root mean square of successive differences in NN intervals) detects only short-term HRV and therefore represents vagal heart rate modulation. [url:https://pubmed.ncbi.nlm.nih.gov/23093257/] root mean square of successive differences in normal-to-normal intervals RMSSD root mean square of subsequent RR differences root mean square of successive difference of NN intervals root mean square of successive differences in normal-to-normal R-R intervals root mean square successive difference square root of the mean squared difference of successive RR intervals PMID:24886422 MIO:02849 standard deviation of average normal-to-normal intervals SD of 5 min averaged NN intervals SD of average NN intervals SDANN standard deviation of average NN intervals standard deviation of the 5-minute average of N-N intervals in ms standard deviation of the averages of NN intervals EFO:0009256 PMID:24886422 PMID:32393179 MIO:02850 SDNN was taken as an indice of total variability.[url:https://pubmed.ncbi.nlm.nih.gov/32393179/] Quantification of the intervals between normal heartbeats, expressed as standard deviation. [url:http://www.ebi.ac.uk/efo/EFO_0009256] standard deviation of normal-to-normal intervals SD of all N–N intervals SDNN standard deviation of N-N intervals standard deviation of N-N intervals in ms standard deviation of RR intervals standard deviation of normal-to-normal R-R intervals standard deviation of the NN inter beat intervals standard deviation of the normal-to-normal inter beat intervals GSSO:006865 NCIT:C92619 MIO:02851 Adverse psychological and behavioral reactions caused by the pressures and demands of employers or clients or other factors, such as the physical environment of the workplace, workplace violence; or workplace bullying. [url:http://purl.obolibrary.org/obo/GSSO_006865] occupational stress Job strain job stress job-related stress specific work related stressful life events stress at work MIO:02852 financial stress financial strain MIO:02853 age 65 years or older age >/=65 years age >64 years age above 64 years age over 64 years age ≥65 years aged >64 years aged over 64 years at least 65 years of age at least 65 years old over 64 years of age over 64 years old MIO:02854 age between 60 and 69 years 60-69 years old age 60-69 MIO:02855 Major adverse cardiovascular events (MACE, or major adverse cardiac events) is a composite endpoint frequently used in cardiovascular research.Despite widespread use of the term in clinical trials, the definitions of MACE can differ, which makes comparison of similar studies difficult. [url:https://en.wikipedia.org/wiki/Major_adverse_cardiovascular_events] major adverse cardiovascular events MACE MACEs major adverse cardiac events major cardiovascular events HP:0001297 MSH:D020521 PMID:22537796 PMID:9034940 SNOMED:230690007 UMLS:C0038454 MIO:02856 Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to the brain. [url:http://purl.obolibrary.org/obo/HP_0001297] stroke cerebral vascular events cerebrovascular accident NCIT:C54197 MIO:02857 An expected natural death from a cardiac cause. This condition usually occurs in persons with pre-existing cardiac abnormalities or disease. [url:http://purl.obolibrary.org/obo/NCIT_C54197] non-sudden cardiac death non-SCD HP:0001645 ICD11:MC82.Z PMID:28033290 PMID:7242416 PMID:84897 SNOMED:95281009 MIO:02858 The heart suddenly and unexpectedly stops beating resulting in death within a short time period (generally within 1 h of symptom onset). [url:http://purl.obolibrary.org/obo/HP_0001645] sudden cardiac death SCD premature sudden cardiac death sudden arrhythmic death NCIT:C156427 MIO:02859 A death attributed to the progression of a cancer-related pathologic condition. [url:http://purl.obolibrary.org/obo/NCIT_C156427] cancer death cancer-related death SNOMED:50514002 MIO:02860 instantaneous death NCIT:C119204 MIO:02861 A finding of a hospitalization event due to a heart failure diagnosis. An event where the patient is admitted to the hospital with a primary diagnosis of heart failure (HF), where the length of stay is at least 24 hours (or extends over a calendar date), where the patient exhibits new or worsening symptoms of HF on presentation, has objective evidence of new or worsening HF, and receives initiation or intensification of treatment specifically for HF. [url:http://purl.obolibrary.org/obo/NCIT_C119204] heart failure hospitalization admission for heart failure hospitalization due to heart failure hospitalization for congestive heart failure hospitalization for heart failure readmission due to heart failure readmission for heart failure rehospitalization due to HF NCIT:C76395 UMLS:C1121991 MIO:02862 cangrelor AR-C69931MX Kengreal cangrelor NCIT:C61972 MIO:02863 A thienopyridine derivative with anticoagulant activity. Ticlopidine inhibits adenosine-diphosphate (ADP) binding to its platelet receptor. This prevents ADP activation and inhibits platelet expression of the glycoprotein (GP) IIb/IIIA receptors, binding of fibrinogen to platelet glycoprotein GP IIb-IIIa and platelet-platelet interaction. This results in increased bleeding time. [url:http://purl.obolibrary.org/obo/NCIT_C61972] ticlopidine CHEBI:35475 NCIT:C257 UMLS:C0003211 MIO:02864 A pharmacological agent that is not a steroid and has potential anti-inflammatory, analgesic, antipyretic and anti-platelet activities. Most nonsteroidal anti-inflammatory drugs (NSAIDs) act by inhibiting the conversion of arachidonic acid to the precursors of prostaglandin and thromboxane by cyclooxygenase enzymes. [url:http://purl.obolibrary.org/obo/NCIT_C257] nonsteroidal antiinflammatory drug NSAID NSAID medications NSAIDs nonselective nonsteroidal antiinflammatory drugs nonsteroidal antiinflammatory drug nonsteroidal antiinflammatory drugs CHEBI:46195 NCIT:C198 UMLS:C0000970 MIO:02865 A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has yet to be fully determined, acetaminophen may inhibit the nitric oxide (NO) pathway mediated by a variety of neurotransmitter receptors including N-methyl-D-aspartate (NMDA) and substance P, resulting in elevation of the pain threshold. The antipyretic activity may result from inhibition of prostaglandin synthesis and release in the central nervous system (CNS) and prostaglandin-mediated effects on the heat-regulating center in the anterior hypothalamus. [url:http://purl.obolibrary.org/obo/NCIT_C198] acetaminophen 4-Hydroxyacetanilide APAP N-(4-Hydroxyphenyl)acetamide paracetamol tylenol CHEBI:51211 NCIT:C81653 MIO:02866 A secondary alcohol that is propan-2-ol substituted by a 2-allylphenoxy group at position 1 and an isopropylamino group at position 3. It is a beta-adrenergic antagonist used as a antihypertensive, anti-arrhythmia and a sympatholytic agent. [url:http://purl.obolibrary.org/obo/CHEBI_51211] alprenolol NCIT:C62073 MIO:02867 A synthetic, nonselective beta-adrenergic receptor blocker with antianginal, antiarrhythmic, antihypertensive properties. Propranolol competitively antagonizes beta-adrenergic receptors, thereby causing negative chronotropic and inotropic effects leading to a reduction in cardiac output. [url:http://purl.obolibrary.org/obo/NCIT_C62073] propranolol 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol CHEBI:3127 NCIT:C61653 UMLS:C0053799 MIO:02868 A selective beta-1 adrenergic receptor antagonist with antihypertensive activity and devoid of intrinsic sympathomimetic activity. Bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, bisoprolol prevent the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels. [url:http://purl.obolibrary.org/obo/NCIT_C61653] bisoprolol CHEBI:3441 NCIT:C28906 UMLS:C0054836 MIO:02869 A synthetic antihypertensive methoxyphenoxy- 2-propanol derivative with no intrinsic sympathomimetic activity, Carvedilol acts as a nonselective beta-adrenoceptor blocking agent (S(-) enantiomer) and as an alpha 1-adrenoceptor blocker (R(+) and S(-) enantiomers). Its acts more strongly on beta-receptors than on alpha 1-receptors, reduces peripheral vascular resistance by vasodilation, and prevents reflex tachycardia (beta-blockade) so that heart rate is either unchanged or decreased. Carvedilol also reduces renin release through beta-blockade. [url:http://purl.obolibrary.org/obo/NCIT_C28906] carvedilol coreg CHEBI:4670 NCIT:C61733 MIO:02870 A synthetic catecholamine with sympathomimetic activity. Dobutamine is a direct-acting inotropic agent and an adrenergic agonist that stimulates primarily the beta-1 adrenoceptor, with lesser effect on beta-2 or alpha receptors. Via beta-1 adrenoceptor of the heart, this agent induces positive inotropic effect with minimal changes in chronotropic activities or systemic vascular resistance. Dobutamine also causes vasodilation by stimulating beta-2 adrenergic receptors in blood vessels, augmented by reflex vasoconstriction resulting in increased cardiac output. [url:http://purl.obolibrary.org/obo/NCIT_C61733] dobutamine 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol DL-dobutamine dobutamin dobutamina dobutaminum rac-dobutamine racemic-dobutamine CHEBI:6904 NCIT:C61845 UMLS:C0025859 MIO:02871 A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion. [url:http://purl.obolibrary.org/obo/NCIT_C61845] metoprolol NCIT:C32089 MIO:02872 A left coronary artery branch that descends on the anterior portion of the heart through the anterior interventricular groove. [url:http://purl.obolibrary.org/obo/NCIT_C32089] anterior descending coronary artery LAD LAD territory anterior descending coronary artery coronary artery, anterior descending left anterior descending coronary artery NCIT:C102286 MIO:02873 The left circumflex coronary artery and all of its branches, including the obtuse marginals, left posterolateral and left posterior descending artery branches. [url:http://purl.obolibrary.org/obo/NCIT_C102286] circumflex artery and its branches circumflex artery and its branches circumflex, obtuse marginals, left posterolateral and left posterior descending artery branches NCIT:C102287 MIO:02874 The segment of the left circumflex artery that is distal to the third marginal branch, located in the atrioventricular groove. [url:http://purl.obolibrary.org/obo/NCIT_C102287] circumflex artery AV groove continuation artery CIRC AV circumflex artery AV groove continuation artery segment NCIT:C12874 MIO:02875 An artery arising from the bifurcation of the left coronary artery that runs along the coronary grove with branches supplying the atria and ventricles. [url:http://purl.obolibrary.org/obo/NCIT_C12874] circumflex branch of the left coronary artery circumflex branch of left coronary artery circumflex branch of the left coronary artery left circumflex coronary artery NCIT:C32458 MIO:02876 One of the arteries arising from the left anterior descending (LAD) artery that supply the anterolateral wall. [url:http://purl.obolibrary.org/obo/NCIT_C32458] diagonal branch of the anterior descending artery diagonal branch of the anterior descending artery NCIT:C102290 MIO:02877 The segment of the left circumflex artery that is between the second and third obtuse marginal branches. [url:http://purl.obolibrary.org/obo/NCIT_C102290] distal circumflex artery DCIRC distal circumflex artery distal circumflex artery segment NCIT:C102295 MIO:02878 The segment of the left anterior descending (LAD) artery that is distal to the third diagonal branch. [url:http://purl.obolibrary.org/obo/NCIT_C102295] distal left anterior descending artery DLAD distal LAD artery distal LAD artery segment distal left anterior descending artery NCIT:C102297 MIO:02879 The first artery arising from the left anterior descending (LAD) artery that supplies the anterolateral wall, when counted from proximal to distal. [url:http://purl.obolibrary.org/obo/NCIT_C102297] first diagonal branch artery 1ST DIAG first diagonal branch artery first diagonal branch artery segment NCIT:C102298 MIO:02880 In an individual with a left-dominant heart, this is the first branch that arises from the circumflex artery atrioventricular groove continuation when counted from proximal to distal. It supplies the posterolateral wall. [url:http://purl.obolibrary.org/obo/NCIT_C102298] first left posterolateral branch artery 1ST LPL first left posterolateral branch artery first left posterolateral branch artery segment NCIT:C102299 MIO:02881 The first artery arising from the left circumflex artery that supplies the lateral wall, when counted from proximal to distal. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102299] first obtuse marginal branch artery 1st om first left marginal artery first obtuse marginal branch artery first obtuse marginal branch artery segment NCIT:C102307 MIO:02882 The lateral branch distal to a bifurcation of the first diagonal artery. [url:http://purl.obolibrary.org/obo/NCIT_C102307] lateral first diagonal branch artery LAT 1ST DIAG lateral first diagonal branch artery lateral first diagonal branch artery segment NCIT:C102308 MIO:02883 The lateral branch distal to a bifurcation of the first obtuse marginal artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102308] lateral first obtuse marginal branch artery first obtuse marginal lateral branch lat 1st om lateral first obtuse marginal branch artery lateral first obtuse marginal branch artery segment NCIT:C102309 MIO:02884 The lateral branch distal to a bifurcation of the ramus intermedius artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102309] lateral ramus intermedius artery lat ramus lateral ramus intermedius artery lateral ramus intermedius artery segment NCIT:C102310 MIO:02885 The lateral branch distal to a bifurcation of the second diagonal artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102310] lateral second diagonal branch artery lat 2nd diag lateral second diagonal branch artery lateral second diagonal branch artery segment NCIT:C102311 MIO:02886 The lateral branch distal to a bifurcation of the second obtuse marginal artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102311] lateral second obtuse marginal branch artery lat 2nd om lateral second obtuse marginal branch artery lateral second obtuse marginal branch artery segment second obtuse marginal lateral branch NCIT:C102312 MIO:02887 The lateral branch distal to a bifurcation of the third diagonal artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102312] lateral third diagonal branch artery lat 3rd diag lateral third diagonal branch artery lateral third diagonal branch artery segment NCIT:C102425 MIO:02888 The lateral branch distal to a bifurcation of the third obtuse marginal artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102425] lateral third obtuse marginal branch artery lat 3rd om lateral third obtuse marginal branch artery lateral third obtuse marginal branch artery segment third obtuse marginal lateral branch NCIT:C102313 MIO:02889 The arteries that arise from the left anterior descending (LAD) artery that supply the interventricular septum. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102313] left anterior descending septal perforator artery lad septal perforator artery lad septal perforator artery segments lad sp left anterior descending septal perforator artery NCIT:C102314 MIO:02890 In an individual with a left-dominant heart, this branch arises from the circumflex artery atrioventricular groove continuation and supplies the inferior apex of the heart. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102314] left posterolateral descending artery left posterolateral descending artery left posterolateral descending artery segment lpda NCIT:C102326 MIO:02891 The segment of the left circumflex artery between the first and second marginal branches. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102326] mid-circumflex artery mcirc mid-circumflex artery mid-circumflex artery segment NCIT:C102327 MIO:02892 All of the arterial branches distal to the proximal left anterior descending coronary artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102327] mid-distal left anterior descending coronary artery and all diagonal coronary branches mid-distal left anterior descending coronary artery and all diagonal coronary branches mid/distal left anterior descending coronary artery and all diagonal coronary branches NCIT:C102328 MIO:02893 The segment of the left anterior descending (LAD) artery between the first and third diagonal branches. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102328] mid-left anterior descending artery mid-lad artery mid-lad artery segment mid-left anterior descending artery mlad NCIT:C102331 MIO:02894 The section of the left circumflex coronary artery that arises from the left main coronary artery and extends to the first marginal branch. [url:http://purl.obolibrary.org/obo/NCIT_C102331] proximal circumflex artery PCIRC proximal circumflex artery proximal circumflex artery segment NCIT:C102336 MIO:02895 The section of the left anterior descending coronary artery that arises from the left main coronary artery and extends to the first diagonal branch. [url:http://purl.obolibrary.org/obo/NCIT_C102336] proximal left anterior descending artery PLAD proximal LAD artery proximal LAD artery segment proximal left anterior descending artery NCIT:C102338 MIO:02896 An artery that arises from the left main coronary artery and is positioned between the left anterior descending coronary artery and the circumflex artery. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102338] ramus intermedius artery ramus ramus artery ramus intermedius artery ramus intermedius artery segment NCIT:C102348 MIO:02897 The arteries arising from the right posterior descending artery that supply the interventricular septum. [url:http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owlC102348] septal perforator artery pdsp posterior descending septal perforators artery posterior descending septal perforators artery segment septal perforator artery NCIT:C102350 MIO:02898 The third artery arising from the left anterior descending (LAD) artery that supplies the anterolateral wall, when counted from proximal to distal. [url:http://purl.obolibrary.org/obo/NCIT_C102350] third diagonal branch artery 3RD DIAG third diagonal branch artery third diagonal branch artery segment NCIT:C116171 MIO:02899 The branch of the right coronary artery that supplies blood to the right ventricular wall. [url:http://purl.obolibrary.org/obo/NCIT_C116171] right ventricular branch of right coronary artery right ventricular branch PMID:15286927 MIO:02900 T-waves in the involved leads without ST-elevation grade 1 ischaemia G1I grade 1 ischemia grade I ischaemia grade I ischemia PMID:15286927 MIO:02901 ST-elevation without QRS distortion grade 2 ischaemia G2I grade 2 ischemia grade II ischaemia grade II ischemia PMID:15286927 MIO:02902 ST-elevation and distortion of the terminal QRS complex grade 3 ischaemia G3I grade 3 ischemia grade III ischaemia grade III ischemia PMID:12431316 MIO:02903 ST segment depression in lead V4 ST depression in lead V4 STD in lead V4 PMID:12431316 MIO:02904 ST segment depression in lead V5 ST depression in lead V5 STD in lead V5 MIO:02905 ST segment depression in lead V1-V3 STD in lead V1-V3 PMID:15024768 PMID:9702382 MIO:02906 ST segment depression in lead III STD in lead III lead III ST-segment depression PMID:15024768 MIO:02907 ST segment depression in lead aVF ST depression in lead aVF STD in lead aVF PMID:15024768 MIO:02908 ST segment depression in lead II ST depression in lead II STD in lead II PMID:12431316 MIO:02909 ST segment depression in lead aVL ST depression in lead aVL STD in lead aVL MIO:02910 ST segment depression in lead I ST depression in lead I STD in lead I PMID:12431316 MIO:02911 ST segment depression in lead V6 ST depression in lead V6 STD in lead V6 PMID:26336872 MIO:02912 ST segment elevation in lead V1 STE in V1 PMID:29030902 MIO:02913 ST segment elevation in lead V4R ST-E in lead V4R ST-segment elevation in lead V4R STE in lead V4 R V4R STE MIO:02914 ST segment elevation in lead II ST elevation in II ST elevation in lead II STE in lead II MIO:02915 ST segment elevation in lead III ST elevation in III ST elevation in lead III STE in lead III MIO:02916 ST segment elevation in lead aVF ST elevation in aVF ST elevation in lead aVF STE in lead aVF MIO:02917 ST segment elevation in lead aVL ST elevation in aVL ST elevation in lead aVL STE in aVL STE in lead aVL MIO:02918 ST segment elevation in lead I ST elevation in I ST elevation in lead I STE in I STE in lead I PMID:25766970 MIO:02919 ST segment elevation in lead V6 ST elevation in lead V6 ST-segment elevation in V6 STE in lead V6 PMID:10781353 MIO:02920 dobutamine-induced ST segment elevation dobutamine ST elevation dobutamine-induced ST elevation dobutamine-induced STE MIO:02921 positive microvolt T wave alternans MONDO:0005355 OMIT:0021001 MIO:02922 Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction. [url:http://purl.obolibrary.org/obo/MONDO_0005355] coronary restenosis coronary artery restenosis restenosis restenosis of infarct-related artery NCIT:C80428 MIO:02923 Percent luminal narrowing of the left main coronary artery, at the point of maximal stenosis of the left main coronary artery. [url:http://purl.obolibrary.org/obo/NCIT_C80428] left main coronary artery stenosis LMCS PMID:9812084 MIO:02924 Stenoses were considered “complex” in the presence of overhanging edges, irregular borders, or ulceration or thrombus. [url:https://pubmed.ncbi.nlm.nih.gov/9812084/] complex stenosis complex additional stenosis complex stenoses complex stenosis morphology SNOMED:371804009 MIO:02925 left main coronary artery disease LMTD diseased left main trunk left main disease left main trunk disease PMID:30153967 MIO:02926 fixed coronary atherosclerosis XCO:0000549 MIO:02927 A surgical manipulation causing blockage of the left anterior descending coronary artery, the artery supplying blood to approximately half of the left ventricle of the heart including the anterolateral myocardium, apex, and interventricular septum. [url:http://purl.obolibrary.org/obo/XCO_0000549] left anterior descending coronary artery occlusion LAD blockage LAD occlusion disease of the left anterior descending coronary artery left descending artery occlusion occluded eft anterior descending artery occlusion of the left anterior descending branch total occlusion in the left anterior descending artery widow maker occlusion MIO:02928 left circumflex artery occlusion left circumflex occlusion SNOMED:123642008 MIO:02929 right coronary artery occlusion RCA-related AMI SNOMED:123641001 MIO:02930 left coronary artery occlusion left coronary artery obstruction EFO:1001483 MIO:02931 Coronary disease that has not progressed to the point of causing significant occlusion (blockage) of the coronary arteries. [url:http://www.ebi.ac.uk/efo/EFO_1001483] non-obstructive coronary artery disease NOCAD PMID:26922236 MIO:02932 Obstructive coronary artery disease was defined as stenosis > 50% of the diameter of the left main coronary artery or stenosis > 70% of the diameter of a major epicardial vessel or branch vessel that was > 2.0 mm in diameter. [url:https://pubmed.ncbi.nlm.nih.gov/26922236/] obstructive coronary artery disease OCAD obstructive CAD PMID:29266736 MIO:02933 Side branch occlusion was defined as the absence or decrease of flow with thrombolysis in MI (TIMI) grade 1 of a side branch with diameter </=2 mm on final angiogram. [url:https://pubmed.ncbi.nlm.nih.gov/32659048/] side branch occlusion branch segment occlusion NCIT:C100020 MIO:02934 There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in three coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery and greater than or equal to 50% stenosis in the right coronary artery). [url:http://purl.obolibrary.org/obo/NCIT_C100020] three vessel coronary disease 3-vessel disease 3VD three vessel disease three-vessel CAD three-vessel coronary artery disease NCIT:C100023 MIO:02935 There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in two coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery). (ACC) [url:http://purl.obolibrary.org/obo/NCIT_C100023] two vessel coronary disease two vessel disease SNOMED:281091000 MIO:02936 ischemic myocardial dysfunction Ischaemic myocardial dysfunction postischemic dysfunction NCIT:C116140 SNOMED:413444003 MIO:02937 An electrocardiographic finding assessment of new or presumed new significant ST-segment-T wave (ST-T) changes or new left bundle branch block consistent with acute myocardial ischemia. [url:http://purl.obolibrary.org/obo/NCIT_C116140] acute myocardial ischemia acute myocardial ischaemia NCIT:C119207 MIO:02938 Definite evidence of inducible myocardial ischemia believed to be responsible for the myocardial ischemic symptoms/signs, demonstrated by any of the following: a) an early positive exercise stress test, defined as ST elevation of greater than or equal to 2 mm ST depression prior to 5 mets, b) stress echocardiography (reversible wall motion abnormality), c) myocardial scintigraphy (reversible perfusion defect), d) MRI (myocardial perfusion deficit under pharmacologic stress). (Hicks KA, Tcheng JE, Bozkurt B, Chaitman BR, Cutlip DE, Farb A, Fonarow GC, Jacobs JP, Jaff MR, Lichtman JH, Limacher MC, Mahaffey KW, Mehran, R, Nissen SE, Smith EE, Targum SL. 2014 ACC/AHA Key Data Elements and Definitions For Cardiovascular Endpoint Events In Clinical Trials: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Cardiovascular End Points Data Standards) J Am Coll Cardiol 2014; In Press) [url:http://purl.obolibrary.org/obo/NCIT_C119207] inducible myocardial ischemia SNOMED:233823002 MIO:02939 silent myocardial ischemia asymptomatic ischaemia asymptomatic ischemia silent ischaemia silent ischemia silent myocardial ischaemia SNOMED:67754003 MIO:02940 aortic valve sclerosis AVS aortic sclerosis senile sclerosis of aortic cusp HP:0006702 MIO:02941 Acute occurrence of a dissection (tear within the tunica intima and entry of blood into the tunica media) of a coronary artery. [url:http://purl.obolibrary.org/obo/HP_0006702] coronary artery dissection coronary dissection EFO:0000266 MIO:02942 aortic stenosis aortic valve stenosis rheumatic aortic stenosis rheumatic aortic valve stenosis stenosed aortic valve EFO:0003914 MIO:02943 Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen. [ url:http://purl.obolibrary.org/obo/NCIT_C35768 ] atherosclerosis atheroscleroses atherosclerosis of artery atherosclerotic cardiovascular disease atherothrombotic burden atherothrombotic process NCIT:C99537 MIO:02944 Occlusion of the lumen of a vein by a thrombus that has migrated from a distal site via the blood stream. [url:http://purl.obolibrary.org/obo/NCIT_C99537] venous thromboembolism NCIT:C50486 MIO:02945 An ischemic condition of the brain, producing a persistent focal neurological deficit in the area of distribution of the cerebral arteries. [url:http://purl.obolibrary.org/obo/NCIT_C50486] cerebral infarction cerebral ischemia NCIT:C50781 MIO:02946 A brief attack (from a few minutes to an hour) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. A transient episode of cerebral dysfunction of vascular origin with no persistent neurological deficit. A disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. [url:http://purl.obolibrary.org/obo/NCIT_C50781] transient ischemic attack TIA transient ischaemic attack transient ischemic attacks EFO:0004911 NCIT:C176014 MIO:02947 An autosomal dominant condition caused by mutation(s) in the APOB gene, encoding apolipoprotein B-100. It is characterized by hypercholesterolemia and abnormal low-density lipoproteins. [url:http://purl.obolibrary.org/obo/NCIT_C176014] familial hypercholesterolemia familial hyperbetalipoproteinaemia familial hypercholesteremia familial hypercholesterolaemia fredrickson type IIa hyperlipoproteinemia fredrickson type IIa lipidaemia hyperbetalipoproteinemia hyperlipoproteinemia type II SNOMED:132281000119108 MIO:02948 acute deep vein thrombosis SNOMED:473155009 MIO:02949 history of angioplasty history of previous angioplasty MIO:02950 history of coronary artery bypass grafting history of CABG history of coronary artery bypass graf SNOMED:405741001 MIO:02951 history of percutaneous coronary intervention history of PCI previous PCI HP:0011711 MIO:02952 Conduction block in the anterior division of the left bundle branch of the bundle of His. [ DDD:dbrown ] [url:http://purl.obolibrary.org/obo/HP_0011711] left anterior fascicular block left anterior hemiblock SNOMED:251123001 MIO:02953 complete right bundle branch block CRBBB SNOMED:46136006 MIO:02954 electrocardiogram with exercise test exercise ECG exercise electrocardiogram exercise electrocardiograph exercise electrocardiography exercise stress ECG test exercise stress electrocardiogram NCIT:C123976 MIO:02955 An insulated electrical conductor designed to connect to an electrocardiogram machine. [url:http://purl.obolibrary.org/obo/NCIT_C123976] electrocardiogram lead SNOMED:46825001 MIO:02956 electrocardiographic monitoring ECG monitoring cardiovascular monitoring by ECG OMIT:0015505 MIO:02957 Vectorcardiography (VCG) is a method of recording the magnitude and direction of the electrical forces that are generated by the heart by means of a continuous series of vectors that form curving lines around a central point. [url:https://en.wikipedia.org/wiki/Vectorcardiography] vectorcardiography VCG NCIT:C123444 MIO:02958 A continuous electrocardiographic (ECG) recording that utilizes twelve leads, though the lead placement may vary from the standard 12 Lead ECG placement. Examples include, but are not limited to, 12 lead Holter with modified Mason-Likar lead placements, 12 lead exercise ECGs, and 12 lead telemetry systems. [url:http://purl.obolibrary.org/obo/NCIT_C123444] 12 lead continuous electrocardiography 12 lead ECG 12 lead continuous ECG 12 lead electrocardiogram 12 lead electrocardiography 12-lead ECGs 12-lead electrocardiogram MIO:02959 Strain rate imaging is a method in echocardiography (medical ultrasound) for measuring regional or global deformation of the myocardium (heart muscle). The term "deformation" refers to the myocardium changing shape and dimensions during the cardiac cycle. If there is myocardial ischemia, or there has been a myocardial infarction, in part of the heart muscle, this part is weakened and shows reduced and altered systolic function. Also in regional asynchrony, as in bundle branch block, there is regional heterogeneity of systolic function. By strain rate imaging, the simultaneous function of different regions can be displayed and measured. The method was first based on colour tissue Doppler. [url:https://en.wikipedia.org/wiki/Strain_rate_imaging] strain rate imaging strain doppler echocardiography strain echocardiography strain-encoded imaging SNOMED:703338002 MIO:02960 dobutamine stress echocardiography DSE echocardiography during dobutamine infusion stress echocardiography using dobutamine MIO:02961 dipyridamole stress echocardiography DET dipyridamole echocardiography dipyridamole echocardiography test NCIT:C74786 MIO:02962 free thyroxine T4-free T4FR free T4 CHEBI:25681 EFO:0010119 MIO:02963 A family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the omega-3 position, i.e., the third bond from the methyl end of the fatty acid. [url:http://purl.obolibrary.org/obo/CHEBI_25681] omega-3 fatty acid N-3 polyunsaturated fatty acid Omega-3 n-3 PUFAs n-3 fatty acid n-3 fatty acids omega-3 fatty acids omega-3 polyunsaturated fatty acid NCIT:C68355 MIO:02964 A polyunsaturated long-chain fatty acid with a 20-carbon backbone and exactly 2 double bonds. At least 5 different isomers can be called by this name. [url:http://purl.obolibrary.org/obo/NCIT_C68355] eicosadienoic acid EDA fatty acid 20:2 EFO:0006826 NCIT:C68401 MIO:02965 A polyunsaturated long-chain fatty acid with an 18-carbon backbone and double bonds originating from the 6th position and the 8th, 9th, 10th, 11th, 12th or 13th positions from the methyl end. The bond geometry of the molecule induces a kink in the main axis of the aliphatic chain at the n-6 position. There are at least 8 different isomers that can be called by this name. [url:http://purl.obolibrary.org/obo/NCIT_C68401] octadecadienoic acid n-6 trans 18:2 trans-FA 18:2 trans-fatty acid 18:2 trans-fatty acids fatty acid 18:2 n-6 trans trans/trans-18:2 fatty acid NCIT:C68383 MIO:02966 A class of monounsaturated fatty acids with 16 carbons and the double bond in the trans formation. [url:http://purl.obolibrary.org/obo/NCIT_C68383] hexadecenoic acid trans 16:1 trans-FA 16:1 trans-fatty acid 16:1 trans-fatty acids fatty acid 16:1 trans hexadecenoic acid trans CHEBI:47775 NCIT:C105587 MIO:02967 Cholesterol esters and free cholesterol which are contained in or bound to high-density lipoproteins (HDL). [url:http://purl.obolibrary.org/obo/CHEBI_47775] high-density lipoprotein cholesterol HDL cholesterol HDL-C alpha-lipoprotein cholesterol high density lipoprotein cholesterol CHEBI:47774 NCIT:C105588 MIO:02968 Cholesterol esters and free cholesterol which are contained in or bound to low-density lipoproteins (LDL). [url:http://purl.obolibrary.org/obo/CHEBI_47774] low-density lipoprotein cholesterol LDL cholesterol LDL-C beta-lipoprotein cholesterol low density lipoprotein cholesterol EFO:0005688 SNOMED:312260007 MIO:02969 non-high-density lipoprotein cholesterol (NHDL), calculated by subtracting the amount of cholesterol in the HDL fraction from total cholesterol, quantifies almost all potentially atherogenic apolipoprotein B containing lipoproteins encompassing cholesterol bound to low-density lipoproteins (LDL), very low-density lipoproteins, intermediate-density lipoproteins, lipoprotein(a), chylomicrons, and chylomicron remnants [url:http://www.ebi.ac.uk/efo/EFO_0005688] non-high density lipoprotein cholesterol NHDL cholesterol non-HDL-C non-high-density lipoprotein cholesterol CHEBI:47773 EFO:0008317 MIO:02970 Cholesterol esters and free cholesterol which are contained in or bound to very low density lipoproteins (VLDL). very-low-density lipoprotein cholesterol VLDL VLDL cholesterol VLDL-C very low density lipoprotein cholesterol very low-density lipoprotein cholesterol MIO:02971 CK-MM3/CK-MM1 isoforms SNOMED:237623001 MIO:02972 acute hyperglycemia acute hyperglycaemia SNOMED:237624007 MIO:02973 Stress hyperglycemia (also called stress diabetes or diabetes of injury) is a medical term referring to transient elevation of the blood glucose due to the stress of illness. It usually resolves spontaneously, but must be distinguished from various forms of diabetes mellitus. [url:https://en.wikipedia.org/wiki/Stress_hyperglycemia] stress hyperglycemia diabetes of injury stress diabetes stress hyperglycaemia MONDO:0004790 MIO:02974 A reversible condition wherein large vacuoles of triglyceride fat accumulate in liver cells via the process of steatosis. [url:http://purl.obolibrary.org/obo/MONDO_0004790] fatty liver disease fatty change of liver fatty liver hepatic lipidosis steatosis of liver NCIT:C113609 MIO:02975 Hepatic necrosis, inflammation, or scarring due to any cause that persists for more than 6 months. Manifestations may include signs and symptoms of cholestasis, portal hypertension, and/or abnormal liver function tests. [url:http://purl.obolibrary.org/obo/NCIT_C113609] chronic liver disease DOID:5082 MP:0003046 MIO:02976 liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure [url:http://purl.obolibrary.org/obo/MP_0003046] liver cirrhosis cirrhosis of liver hepatic cirrhosis NCIT:C26922 MIO:02977 A disorder characterized by the inability of the liver to metabolize chemicals in the body. Causes include cirrhosis and drug-induced hepatotoxicity. Signs and symptoms include jaundice and encephalopathy. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase. [url:http://purl.obolibrary.org/obo/NCIT_C26922] liver failure hepatic failure NCIT:C84637 UMLS:C4014770 MIO:02978 A chronic inflammatory process causing damage and fibrosis of the pancreatic parenchyma. Signs and symptoms include abdominal pain, malabsorption and diabetes mellitus. [url:http://purl.obolibrary.org/obo/NCIT_C84637] chronic pancreatitis NCIT:C35326 MIO:02979 A chronic inflammatory process that affects the tissues that surround and support the teeth. [url:http://purl.obolibrary.org/obo/NCIT_C35326] chronic periodontitis NCIT:C71990 MIO:02980 The pod-enclosed seed of various leguminous herbs as well as other vegetable seeds or fruits that resemble true beans.[url:http://purl.obolibrary.org/obo/NCIT_C71990] bean intake bean beans NCIT:C67038 SNOMED:226331004 MIO:02981 A class of dietary fatty acids containing two or more double bonds.[url:http://purl.obolibrary.org/obo/NCIT_C67038] polyunsaturated fatty acid intake PUFA polyunsaturated fatty acid polyunsaturated fatty acids NCIT:C68440 MIO:02982 A class of dietary fatty acids containing at least one double bond in the trans formation. A type of fat that has certain chemical properties and is usually found in processed foods such as baked goods, snack foods, fried foods, shortening, margarine, and certain vegetable oils. Eating trans fat increases blood cholesterol levels and the risk of heart disease. [url:http://purl.obolibrary.org/obo/NCIT_C68440] trans fatty acid intake trans fat trans fatty acid EFO:0008355 MIO:02983 quantification of the amount of heme iron acquired through dietary intake [url:http://www.ebi.ac.uk/efo/EFO_0008355] dietary heme iron intake SNOMED:286604002 MIO:02984 A compound containing vitamin A, a natural, fat-soluble vitamin that plays a vital role in a variety of physiologic processes including immune function, vision, reproduction, and cellular growth and differentiation. Upon administration, the various forms of vitamin A are solubilized into micelles in the intestinal lumen and absorbed by duodenal mucosal cells.[url:http://purl.obolibrary.org/obo/NCIT_C938] vitamin A intake A vitamin vitamin A NCIT:C942 SNOMED:226349004 MIO:02985 A natural fat-soluble antioxidant with potential chemopreventive activity. Also known as tocopherol, vitamin E ameliorates free-radical damage to biological membranes, protecting polyunsaturated fatty acids (PUFA) within membrane phospholipids and within circulating lipoproteins. Peroxyl radicals react 1000-fold faster with vitamin E than with PUFA. In the case of oxygen free radical-mediated tumorigenesis, vitamin E may be chemopreventive.[url:http://purl.obolibrary.org/obo/NCIT_C942] vitamin E intake E vitamin vitamin E vitamin E compound MIO:02986 A class of nutrients that are in the water-soluble B-vitamin family. B vitamins include thiamine, riboflavin, niacin (nicotinic acid), niacinamide (nicotinamide), the vitamin B6 group (including pyridoxine, pyridoxal, pyridoxamine), biotin, pantothenic acid, folic acid, and possibly para-aminobenzoic.[url:http://purl.obolibrary.org/obo/NCIT_C45812] vitamin B intake B vitamin B vitamin family B vitamins NCIT:C510 SNOMED:792807003 MIO:02987 A collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production.[url:http://purl.obolibrary.org/obo/NCIT_C510] folic acid intake folacin folate folic acid folvite pteroylglutamic acid pteroylmonoglutamic acid vitamin B9 vitamin Bc vitamin M MAXO:0000109 NCIT:C68507 SNOMED:286586005 MIO:02988 Class of water-soluble antioxidant vitamins which are cofactors in the biosynthesis of collagen, carnitine, and neurotransmitters, and can quench a variety of reactive oxygen and nitrogen species. (DRI) A nutrient that the body needs in small amounts to function and stay healthy. Vitamin C helps fight infections, heal wounds, and keep tissues healthy. It is an antioxidant that helps prevent cell damage caused by free radicals (highly reactive chemicals). Vitamin C is found in all fruits and vegetables, especially citrus fruits, strawberries, cantaloupe, green peppers, tomatoes, broccoli, leafy greens, and potatoes. It is water-soluble (can dissolve in water) and must be taken in every day. Vitamin C is being studied in the prevention and treatment of some types of cancer.[url:http://purl.obolibrary.org/obo/NCIT_C68507] Addition of vitamin C to the diet for adequate and complete nutrition. [url:http://purl.obolibrary.org/obo/MAXO_0000109] vitamin C intake ascorbic acid intake dietary supplementation of vitamin C intake of vitamin C supplementation of vitamin C vitamin C supplemental intake MIO:02989 age under 55 years age 54 years or younger age </=54 years age <55 years age below 55 years age ≤54 years aged </=54 years aged <55 years aged under 55 years under 55 years of age under 55 years old MIO:02990 strain of returning to work stress of returning to work MIO:02991 age above 65 years above 65 years of age age >/=66 years age >65 years age of more than 65 age ≥66 years aged >65 years aged over 65 aged over 65 years at least 66 years of age at least 66 years old over 65 years of age over 65 years old MIO:02992 age between 65 and 74 years 65-74 years old age 65-74 PMID:23990026 MIO:02993 Adverse non-fatal cardiac events included unstable angina, symptomatic arrhythmia, repeat revascularization, recurrent MI (reinfarction), and readmission due to heart failure. [url:https://pubmed.ncbi.nlm.nih.gov/23990026/] adverse non-fatal cardiac events cardiovascular events excluding cardiac mortality non-fatal cardiac events nonfatal major adverse cardiovascular event EFO:1001976 MIO:02994 stroke caused by the blockage of blood flow in a brain vessel through a clot or other foreign matters pumped from the heart to the brain [url:http://www.ebi.ac.uk/efo/EFO_1001976] cardioembolic stroke OAE:0001792 MIO:02995 a stroke that occurs when a blood vessel that supplies the brain ruptures and bleeds causing the deficiency of oxygen and nutrients to brain cells and tissues [url:http://purl.obolibrary.org/obo/OAE_0001792] hemorrhagic stroke hemorragic stroke CHEBI:35544 NCIT:C1323 UMLS:C3536910 MIO:02996 Any agent that inhibits prostaglandin G/H synthase (cyclooxygenase or COX), an enzyme that catalyzes the production of prostanoids, including prostaglandins, prostacyclin and thromboxane, from arachidonic acid. Cyclooxygenase inhibitors are a type of non-steroidal anti-inflammatory drug. [url:http://purl.obolibrary.org/obo/NCIT_C1323] cyclooxygenase inhibitor COX inhibitor clyclooxygenases inhibitor prostaglandin G/H synthase inhibitor MIO:02997 ST segment depression in lead V5 greater than lead V4 MIO:02998 ST segment depression in lead III greater than ST segment elevation in lead aVL MIO:02999 ST segment depression in lead aVL greater than lead I MIO:03000 ST segment depression in lead aVL less than lead I MIO:03001 ST segment depression in lead I and aVL MIO:03002 ST segment elevation in lead III greater than lead II MIO:03003 ST segment elevation in lead III less than lead II MIO:03004 sum of ST segment elevation in lead V3 and in lead III MIO:03005 ratio of ST segment depression in lead V3 to ST segment elevation in lead III NCIT:C100081 MIO:03006 Fifty percent or greater stenosis within an existing stent. [url:http://purl.obolibrary.org/obo/NCIT_C100081] in stent restenosis in-stent restenosis stent restenosis PMID:28738488 MIO:03007 left anterior descending artery stenosis LAD stenosis left anterior descending artery (LAD) stenosis MIO:03008 proximal left anterior descending coronary artery occlusion LAD proximal to first diagonal and first septal branch culprit lesion in left anterior descending artery proximal to the origin of the first diagonal branch lesion in the left anterior descending coronary artery in relation to the first septal occlusion of the proximal left anterior descending coronary artery occlusion site in LAD proximal occlusion site in LAD proximal to first diagonal and first septal branch proximal left anterior descending occlusion MIO:03009 proximal left circumflex artery occlusion PMID:31666450 MIO:03010 occlusion of the atrial branch of the right coronary artery ischemic occlusion of the atrial branch of the right coronary artery PMID:29479662 MIO:03011 proximal right coronary artery occlusion NCIT:C116140 MIO:03012 An electrocardiographic finding assessment of new or presumed new significant ST-segment-T wave (ST-T) changes or new left bundle branch block consistent with acute myocardial ischemia. (Thygesen K, Alpert JS, Jaffe AS, et al.: the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction. J Am Coll Cardiol 60(16):1-18, 2012) [http://purl.obolibrary.org/obo/NCIT_C116140] acute myocardial ischemia by ECG assessment AMIEGCHG acute myocardial ischemia ECG change NCIT:C78739 OMIT:0027140 MIO:03013 Fatty tissue which is deposited in the inner lining of the arterial wall. [url:http://purl.obolibrary.org/obo/NCIT_C78739] atherosclerotic plaque plaque EFO:0009783 MIO:03014 A thickening and loss of elasticity of the walls of carotid arteries that occur with formation of atherosclerotic plaques. [url:http://www.ebi.ac.uk/efo/EFO_0009783] carotid atherosclerosis carotid atheroscleroses carotid atherosclerotic disease carotid atherosclerotic diseases HP:0031012 MIO:03015 Thin-cap fibroatheroma is characterized by a relatively large necrotic core with an overlying thin fibrous cap measuring <65 µm typically containing numerous macrophages, and is considered to be the precursor lesion of plaque rupture which is the most common cause of coronary thrombosis. [ http://www.ncbi.nlm.nih.gov/pubmed/27500096 ] [url:http://purl.obolibrary.org/obo/HP_0031012] thin-cap fibroatheroma TCFA SNOMED:257483001 MIO:03016 chest lead SNOMED:257486009 MIO:03017 limb lead SNOMED:257481004 MIO:03018 anterior lead anterior leads SNOMED:257482006 MIO:03019 anterolateral lead SNOMED:257484007 MIO:03020 inferior lead SNOMED:257485008 MIO:03021 inferolateral lead NCIT:C38064 UMLS:C0013801 MIO:03022 An ambulatory electrocardiography technique that records a continuous electrocardiographic rhythm pattern for 24 hours or more to detect heart arrhythmias. [url:http://purl.obolibrary.org/obo/NCIT_C38064] holter monitoring electrocardiographic Holter analyzer holter ECG holter continuous ECG recording holter electrocardiogram holter electrocardiography holter monitor NCIT:C80406 MIO:03023 A recording of cardiac electrical activity during stress or exercise. [url:http://purl.obolibrary.org/obo/NCIT_C80406] stress electrocardiography SNOMED:33442008 MIO:03024 Signal-averaged electrocardiography (SAECG) is a special electrocardiographic technique, in which multiple electric signals from the heart are averaged to remove interference and reveal small variations in the QRS complex, usually the so-called "late potentials". These may represent a predisposition towards potentially dangerous ventricular tachyarrhythmias. [url:https://en.wikipedia.org/wiki/Signal-averaged_electrocardiogram] signal-averaged electrocardiography SAECG signal-averaged ECG signal-averaged electrocardiogram OMIT:0018929 MIO:03025 body surface potential mapping BSPM body surface isochrone map body surface isochrone maps electrocardiographic body surface potential mapping MIO:03026 low-dose dobutamine echocardiography LDE NCIT:C68345 SNOMED:226368001 MIO:03027 A polyunsaturated very long-chain fatty acid with a 22-carbon backbone and 6 double bonds. Four separate isomers can be called by this name. [url:http://purl.obolibrary.org/obo/NCIT_C68345] docosahexaenoic acid C22:6n-3 DHA fatty acid 22:6 NCIT:C67080 MIO:03028 An essential, polyunsaturated, 20-carbon omega-3 fatty acid with anti-inflammatory and potential antineoplastic and chemopreventive activities. Eicosapentaenoic acid (EPA) may activate caspase 3, resulting in apoptosis in susceptible tumor cell populations. In addition, this agent may inhibit cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin synthesis and prostaglandin-mediated inflammatory processes. [url:http://purl.obolibrary.org/obo/NCIT_C67080] eicosapentaenoic acid EPA IPA all cis-5,8,11,14,17-eicosapentaenoic acid fatty acid 20:5 icosapentaenoic acid timnodonic acid MIO:03029 The ratio between the levels of omega-3 polyunsaturated fatty acid and omega-6 polyunsaturated fatty acid. omega-3:omega-6 polyunsaturated fatty acid ratio CMO:0001365 MIO:03030 A calculated measurement in which the amount of HDL, small-particle lipoproteins that promote transport of cholesterol from extrahepatic tissue to the liver for excretion in the bile, in a specified volume of serum is divided by the amount of LDL, relatively large-particle lipoproteins that transport cholesterol to extrahepatic tissue, in the same sample, and presented as a ratio, fraction, quotient or percentage.[url:http://purl.obolibrary.org/obo/CMO_0001365] high-density lipoprotein cholesterol to low-density lipoprotein cholesterol ratio MIO:03031 The ratio between the levels of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol. low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio EFO:0003095 MIO:03032 A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use. [url:http://www.ebi.ac.uk/efo/EFO_0003095] non-alcoholic fatty liver disease NAFLD non-alcoholic fatty liver non-alcoholic fatty liver disease nonalcoholic fatty liver disease NCIT:C72010 MIO:03033 A product from a plant of Asian origin that produces beans used in many food products. Soybean contains isoflavones (estrogen-like substances) that are being studied for the prevention of cancer, hot flashes that occur with menopause, and osteoporosis (loss of bone density). Soybean in the diet may lower cholesterol levels and reduce the risk of heart disease.[url:http://purl.obolibrary.org/obo/NCIT_C72010] soybean intake glycine max soya soybean soybeans intake NCIT:C493 SNOMED:226332006 MIO:03034 Any fatty acid that contains an unsaturated bond originating from the 3rd carbon from the methyl end. Omega-3 fatty acids do not occur naturally with chain lengths shorter than 16 carbon units.[url:http://purl.obolibrary.org/obo/NCIT_C493] n-3 fatty acid intake n-3 fatty acid omega 3 fatty acid omega 3 fatty acid intake omega-3 PUFA omega-3 fatty acids omega-3 polyunsaturated fatty acid omega-3 supplement NCIT:C2563 SNOMED:226336009 MIO:03035 Essential fatty acids obtained from food sources that are necessary for normal biological functions, as well as growth and development. A class of dietary fatty acids with the first double bond at the 6th carbon from the methyl end.[url:http://purl.obolibrary.org/obo/NCIT_C2563] n-6 fatty acid intake n-6 fatty acid n-6 fatty acids omega-6 PUFAs omega-6 fatty acid omega-6 fatty acids NCIT:C689 SNOMED:286583002 MIO:03036 A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C.[url:http://purl.obolibrary.org/obo/NCIT_C689] niacin intake 3-pyridinecarboxylic acid niacin nicotinamide nicotinic acid nicotinic acid amid vitamin B-3 vitamin B3 NCIT:C874 SNOMED:286579002 MIO:03037 A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation. [url:http://purl.obolibrary.org/obo/NCIT_C874] vitamin B1 intake B1 vitamin Vit B1 aneurin thiamin thiamine vitamin B1 PMID:286581000 MIO:03038 An essential human nutrient that is a heat-stable and water-soluble flavin belonging to the vitamin B family. Riboflavin is a precursor of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are of vital importance in normal tissue respiration, pyridoxine activation, tryptophan to niacin conversion, fat, carbohydrate, and protein metabolism, and glutathione reductase mediated detoxification. Riboflavin may also be involved in maintaining erythrocyte integrity. This vitamin is essential for healthy skin, nails, and hair.[url:http://purl.obolibrary.org/obo/NCIT_C808] vitamin B2 intake 6,7-Dimethyl-9-D-ribitylisoalloxazine lactoflavin riboflavin vitamin B2 NCIT:C1334 SNOMED:286584008 MIO:03039 A group of water-soluble vitamins essential for metabolism and normal physiological functions. B6 vitamins, including pyridoxine, pyridoxal, and pyridoxamine, are converted in vivo to pyridoxal phosphate, a cofactor necessary for the synthesis of amino acids, neurotransmitters, and sphingolipids. More than 100 enzymes involved in protein metabolism require vitamin B6 as a cofactor. Vitamin B6 is essential to red blood cell, nervous system, and immune systems functions and helps maintain normal blood glucose levels. Vitamin B6 is found in a wide variety of foods including cereals, beans, meat, poultry, fish, and some fruits and vegetables. [url:http://purl.obolibrary.org/obo/NCIT_C1334] vitamin B6 intake VIT B6 vitamin B6 MIO:03040 age 50 years or younger age </=50 years age ≤50 years MIO:03041 age 70 years or older age >/=70 years age >69 years age above 69 years age over 69 years age ≥70 years aged >69 years aged over 69 years at least 70 years of age at least 70 years old over 69 years of age MIO:03042 age between 66 and 75 years 66-75 years old age 66-75 PMID:18157959 MIO:03043 The recurrent cardiac events was defined as unstable angina pectoris requiring hospitalization (chest pain with ECG changes indicating ischemia), recurrent nonfatal myocardial infarction, unplanned revascularization, or cardiac death, whichever occurred first. [url:https://pubmed.ncbi.nlm.nih.gov/18157959/] recurrent cardiac events recurrent CVD events recurrent cardiovascular disease events recurrent cardiovascular events recurrent coronary events recurrent coronary heart disease events secondary cardiac events CHEBI:50629 NCIT:C80509 UMLS:C1257954 MIO:03044 A subgroup of non-steroidal anti-inflammatory drugs (NSAID) that specifically targets at cyclooxygenase 2, an enzyme involved in pain and inflammation. [url:http://purl.obolibrary.org/obo/NCIT_C80509] COX-2 inhibitor PTGS2 inhibitor cyclooxygenase (COX)-2 cyclooxygenase 2 inhibitors cyclooxygenase II Inhibitor cyclooxygenase-2 inhibitor prostaglandin-endoperoxide synthase 2 inhibitor CHEBI:7476 NCIT:C680 UMLS:C0700017 MIO:03045 A propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of naproxen. Naproxen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. [url:http://purl.obolibrary.org/obo/NCIT_C680] naproxen 6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid RS-3540 d-2-(6-Methoxy-2-naphthyl)propionic acid naprosyn NCIT:C80429 MIO:03046 A narrowing of the proximal portion of the left main coronary artery, usually considered significant if the stenosis is 70% or greater. [url:http://purl.obolibrary.org/obo/NCIT_C80429] proximal left anterior descending coronary artery stenosis LAD artery narrowing proximal to the tirst diagonal branch infarct-related narrowing proximal to the origin of the first diagonal branch left anterior descending artery narrowing proximal to the first diagonal branch left anterior descending artery narrowing proximal to the tirst diagonal branch NCIT:C90412 MIO:03047 A unipolar electrocardiogram lead site; the electrode is placed at the fourth intercostal space on the anterior chest wall (between ribs 4 and 5) to the right of the sternal border. In small animals, it is placed at the right fifth intercostal space near the sternum. [url:http://purl.obolibrary.org/obo/NCIT_C90412] lead site V1 lead C1 lead V1 NCIT:C90414 MIO:03048 A unipolar electrocardiogram lead site; the electrode is placed on the anterior chest wall at the fourth intercostal space (between ribs 4 and 5) to the left of the sternal border. In small animals it corresponds to V2-V3 where it is placed at the 6th left intercostal space near the sternum. In large animals it is placed over the 6th rib at the level of the costochondral junction on the left side of the thorax. [url:http://purl.obolibrary.org/obo/NCIT_C90414] lead site V2 lead V2 NCIT:C90415 MIO:03049 A unipolar electrocardiogram lead site; the electrode is placed on the anterior chest wall midway between leads V2 and V4. In large and small animals, it is placed over the dorsal spinous process of the 7th thoracic vertebra. [url:http://purl.obolibrary.org/obo/NCIT_C90415] lead site V3 lead V3 NCIT:C90416 MIO:03050 A unipolar electrocardiogram lead site; the electrode is placed at the fifth intercostal space on the anterior chest wall (between ribs 5 and 6) at the left midclavicular line. In small animals it corresponds to V4-V6 where it is placed at the 6th left intercostal space near the costochondral junction. In large animals it is placed over the 6th rib at the level of a horizontal line drawn through the scapulohumeral articulation on the left side of the thorax. [url:http://purl.obolibrary.org/obo/NCIT_C90416] lead site V4 lead V4 PMID:2801564 MIO:03051 V4R was placed on the right chest wall in the midclavicular line in the fifth intercostal space and recorded in place of V2. [url:https://pubmed.ncbi.nlm.nih.gov/2801564/] lead site V4R lead V4R NCIT:C90417 MIO:03052 A unipolar electrocardiogram lead site; the electrode is placed on the anterior chest wall level with lead V4 at the left anterior axillary line. In large animals it is placed on the sixth ICS on the right side of the thorax along a line parallel to the level of the point of the shoulder corresponding to the electrical center of the heart (central terminal). [url:http://purl.obolibrary.org/obo/NCIT_C90417] lead site V5 lead V5 NCIT:C90403 MIO:03053 An augmented unipolar lead placed at the sixth intercostal space on the midaxillary line. [url:http://purl.obolibrary.org/obo/NCIT_C90403] lead site V6 lead V6 NCIT:C135387 MIO:03054 An augmented unipolar electrocardiogram limb lead in which the positive electrode is situated at the hindquarters proximal to the sacrum and the negative electrode is a combination of the electrode behind the right ear near the right mastoid process and the electrode near the apex of the heart (located in the ICS of left 5-6 rib close to the sternum). (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C135387] lead site aVF lead aVF lead aVF-ventral lead site aVF-ventral NCIT:C135388 MIO:03055 An augmented unipolar electrocardiogram limb lead in which the positive electrode is near the apex of the heart (located in the ICS of left 5-6 rib close to the sternum) and the negative electrode is a combination of the electrode behind the right ear near the right mastoid process and the electrode on hindquarters proximal to the sacrum. (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C135388] lead site aVL lead aVL lead aVL-axial lead site aVL-axial NCIT:C135389 MIO:03056 An augmented unipolar electrocardiogram limb lead in which the positive electrode is behind the right ear near the right mastoid process and the negative electrode is a combination of the electrode at the hindquarters proximal to the sacrum and the electrode near the apex of the heart (located in the ICS of left 5-6 rib close to the sternum). (CDISC) [url:http://purl.obolibrary.org/obo/NCIT_C135389] lead site aVR lead aVR lead aVR-dorsal lead site aVR-dorsal NCIT:C90408 MIO:03057 A bipolar electrocardiogram limb lead which records the voltage between the negative electrode on the right thoracic limb and the positive electrode on the left thoracic limb. [url:http://purl.obolibrary.org/obo/NCIT_C90408] lead site I lead I NCIT:C90409 MIO:03058 A bipolar electrocardiogram limb lead which records the voltage between the negative electrode on the right thoracic limb and the positive electrode on the left pelvic limb. [url:http://purl.obolibrary.org/obo/NCIT_C90409] lead site II lead II NCIT:C90410 MIO:03059 A bipolar electrocardiogram limb lead which records the voltage between the negative electrode on the left thoracic limb and the positive electrode on the left pelvic limb. [url:http://purl.obolibrary.org/obo/NCIT_C90410] lead site III lead III SNOMED:252417001 MIO:03060 24 hour electrocardiogram 24 hour holter tape 24-hour ECG 24-hour ambulatory electrocardiogram 24-hour ambulatory electrocardiography 24-hour holter ECG 24-hour holter electrocardiogram 24-hour holter electrocardiography NCIT:C68348 MIO:03061 A polyunsaturated very long-chain fatty acid with a 22-carbon backbone and 5 double bonds, originating from the 6th, 9th, 12th, 15th and 18th positions from the methyl end. [url:http://purl.obolibrary.org/obo/NCIT_C68348] docosapentaenoic acid n-6 DPA docosapentaenoic n-6 fatty acid 22:5 n-6 MIO:03062 age under 50 years age 49 years or younger age </=49 years age <50 years age below 50 years age ≤49 years aged <50 years aged under 50 years under 50 years of age under 50 years old MIO:03063 age above 70 years above 70 years of age age >70 years age of more than 70 aged >70 years aged over 70 aged over 70 years over 70 years of age over 70 years old MIO:03064 age between 70 and 79 years 70-79 years old age 70-79 PMID:23418388 MIO:03065 Ischemic cardiac events include recurrent myocardial infarction and unstable angina. [url:https://pubmed.ncbi.nlm.nih.gov/23418388/] ischemic cardiac events cardiac ischemic events cardiovascular ischemic events ischaemic coronary events ischemic events recurrent ACS recurrent acute coronary syndrome recurrent ischaemia recurrent ischemia recurrent ischemic events recurrent myocardial ischemic events subsequent coronary ischemic events MIO:03066 A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis. [url:http://purl.obolibrary.org/obo/NCIT_C1728] celecoxib 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide SC-58635 YM 177 benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]- celebrex celecoxib CHEBI:47381 NCIT:C28985 UMLS:C0012091 MIO:03067 A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. [url:http://purl.obolibrary.org/obo/NCIT_C28985] diclofenac 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid CHEBI:8887 NCIT:C1832 UMLS:C0762662 MIO:03068 A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. [url:http://purl.obolibrary.org/obo/NCIT_C1832] rofecoxib 4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone MK 966 vioxx NCIT:C1869 MIO:03069 A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation. [url:http://purl.obolibrary.org/obo/NCIT_C1869] valdecoxib 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide SC 65872 VALDECOXIB bextra MIO:03070 age 45 years or younger age </= 45 years age ≤45 years MIO:03071 age 74 years or older age >/=74 years age ≥74 years at least 74 years of age at least 74 years old PMID:30571511 MIO:03072 Incident MI is defined as the individual's first MI. When features of MI occur in the first 28 days after an incident event, the second event is not counted as a new MI for epidemiological purposes. If characteristics of MI occur after 28 days following an incident MI, it is considered to be a recurrent MI. [url:https://pubmed.ncbi.nlm.nih.gov/30571511/] recurrent myocardial infarction recurrent MI repeated MI repeated myocardial infarction MIO:03073 age under 45 years age 44 years or younger age </=44 years age <45 years age below 45 years age ≤44 years aged <45 years aged under 45 years under 45 years of age under 45 years old MIO:03074 age 75 years or older age >/=75 years age ≥75 years at least 75 years of age at least 75 years years MIO:03075 age between 75 and 84 years 75-84 years old age 75-84 MIO:03076 age between 30 and 34 years 30-34 years old age 30-34 MIO:03077 age between 35 and 39 years 35-39 years old age 35-39 MIO:03078 age above 75 years above 75 years old age >75 years age of more than 75 aged >75 years aged over 75 aged over 75 years over 75 years of age over 75 years old MIO:03079 age 80 years or older above 79 years of age age >/=80 years age >79 years age above 79 years age of more than 79 age over 79 years age ≥80 years aged >79 years aged over 79 aged over 79 years at least 80 years of age at least 80 years old over 79 years of age over 79 years old MIO:03080 age above 80 years above 80 years of age above 80 years old age >80 years age of more than 80 aged >80 years aged over 80 aged over 80 years over 80 years of age over 80 years old MIO:03081 age 85 years or older age >/=85 years age >84 years age over 84 years age ≥85 years aged >84 years aged over 84 years at least 85 years of age at least 85 years old over 84 years of age over 84 years old EUPATH:0010346 MIO:03082 A time measurement datum of the duration of a health care encounter occuring in a hospital facility. [url:http://purl.obolibrary.org/obo/APOLLO_SV_00000600] duration of hospital stay duration of hospitaliztion length of hospital stay PMID:15148543 PMID:8147296 MIO:03083 TAPSE correlates well with myocardial perfusion stress scintigraphy and coronary angiography and is a simple and safe diagnostic option for patients with suspected or known CAD, including those with recent myocardial infarction. [url:https://pubmed.ncbi.nlm.nih.gov/15148543/] transoesophageal atrial pacing stress echocardiography TAPSE combined two-dimensional echocardiography and transesophageal atrial stimulation echo-pacing transesophageal atrial pacing combined with two-dimensional echocardiography PMID:31206405 MIO:03084 Age-modified shock index (age MSI), defined as age multiplied by MSI. [PMID:31206405] age-modified shock index age MSI PMID:29132649 MIO:03085 Congestive microvascular resistance (hMR) calculated with Doppler flow velocity. [PMID:29132649] hyperemic microvascular resistance hMR NCIT:C102341 MIO:03086 The arterial branch between the right posterior descending artery segment and the first right posterolateral segment. [url: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102341] right posterior atrioventricular artery RPAV right posterior atrioventricular artery segment HGNC:7 alpha-2-macroglobulin A2M CPAMD5 FWP007 S863-7 HGNC:21298 acetoacetyl-CoA synthetase AACS ACSF1 FLJ12389 SUR-5 HGNC:29 ATP binding cassette subfamily A member 1 ABCA1 TGD HGNC:40 ATP binding cassette subfamily B member 1 ABCB1 ABC20 CD243 GP170 P-gp HGNC:60 ATP binding cassette subfamily C member 9 ABCC9 CMD1O SUR2 HGNC:73 ATP binding cassette subfamily G member 1 ABCG1 ABC8 HGNC:74 ATP binding cassette subfamily G member 2 (Junior blood group) ABCG2 ABCP BCRP CD338 EST157481 MXR HGNC:13886 ATP binding cassette subfamily G member 5 ABCG5 STSL HGNC:24278 abhydrolase domain containing 17B, depalmitoylase ABHD17B CGI-67 HGNC:79 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase ABO A3GALNT A3GALT1 HGNC:81 ABR activator of RhoGEF and GTPase ABR MDB HGNC:2707 angiotensin I converting enzyme ACE ACE1 CD143 HGNC:13557 angiotensin I converting enzyme 2 ACE2 HGNC:108 acetylcholinesterase (Cartwright blood group) ACHE HGNC:23692 atypical chemokine receptor 3 ACKR3 GPR159 RDC1 HGNC:124 acid phosphatase 5, tartrate resistant ACP5 HPAP TRAP HGNC:3569 acyl-CoA synthetase long chain family member 1 ACSL1 ACS1 FACL1 LACS LACS1 LACS2 HGNC:129 actin alpha 1, skeletal muscle ACTA1 NEM3 HGNC:130 actin alpha 2, smooth muscle ACTA2 ACTSA HGNC:145 actin gamma 2, smooth muscle ACTG2 ACTSG HGNC:171 activin A receptor type 1 ACVR1 ACVR1A ALK2 SKR1 HGNC:186 adenosine deaminase ADA ADA1 HGNC:195 ADAM metallopeptidase domain 17 ADAM17 CD156B cSVP HGNC:215 ADAM metallopeptidase domain 8 ADAM8 CD156 CD156A MS2 HGNC:16299 ADAM like decysin 1 ADAMDEC1 M12.219 HGNC:217 ADAM metallopeptidase with thrombospondin type 1 motif 1 ADAMTS1 C3-C5 KIAA1346 METH1 HGNC:1366 ADAM metallopeptidase with thrombospondin type 1 motif 13 ADAMTS13 DKFZp434C2322 FLJ42993 MGC118899 MGC118900 TTP VWFCP vWF-CP HGNC:17108 ADAM metallopeptidase with thrombospondin type 1 motif 16 ADAMTS16 ADAMTS16s HGNC:218 ADAM metallopeptidase with thrombospondin type 1 motif 2 ADAMTS2 ADAM-TS2 ADAMTS-3 NPI PCINP hPCPNI HGNC:219 ADAM metallopeptidase with thrombospondin type 1 motif 3 ADAMTS3 ADAMTS-4 KIAA0366 HGNC:223 ADAM metallopeptidase with thrombospondin type 1 motif 7 ADAMTS7 ADAM-TS7 DKFZp434H204 HGNC:13202 ADAM metallopeptidase with thrombospondin type 1 motif 9 ADAMTS9 KIAA1312 HGNC:243 adducin 1 ADD1 HGNC:251 alcohol dehydrogenase 1C (class I), gamma polypeptide ADH1C HGNC:13633 adiponectin, C1Q and collagen domain containing ADIPOQ ACRP30 GBP28 adiponectin apM1 HGNC:40648 ADIPOQ antisense RNA 1 ADIPOQ-AS1 HGNC:24041 adiponectin receptor 2 ADIPOR2 ACDCR2 PAQR2 HGNC:259 adrenomedullin ADM AM HGNC:28898 adrenomedullin 2 ADM2 AM2 FLJ21135 HGNC:281 adrenoceptor alpha 2A ADRA2A ADRAR HGNC:282 adrenoceptor alpha 2B ADRA2B ADRARL1 HGNC:283 adrenoceptor alpha 2C ADRA2C ADRARL2 HGNC:285 adrenoceptor beta 1 ADRB1 HGNC:286 adrenoceptor beta 2 ADRB2 ADRBR B2AR BAR HGNC:288 adrenoceptor beta 3 ADRB3 HGNC:320 advanced glycosylation end-product specific receptor AGER RAGE SCARJ1 HGNC:329 agrin AGRN HGNC:333 angiotensinogen AGT HGNC:336 angiotensin II receptor type 1 AGTR1 AG2S AGTR1A AT1 AT1B AT2R1 AT2R1A AT2R1B HAT1R HGNC:338 angiotensin II receptor type 2 AGTR2 AT2 MRX88 HGNC:349 alpha 2-HS glycoprotein AHSG A2HS FETUA HSGA HGNC:368 A-kinase anchoring protein 10 AKAP10 D-AKAP2 MGC9414 PRKA10 HGNC:391 AKT serine/threonine kinase 1 AKT1 AKT PKB PRKBA RAC RAC-alpha HGNC:399 albumin ALB HGNC:15472 aldehyde dehydrogenase 1 family member A2 ALDH1A2 RALDH2 HGNC:404 aldehyde dehydrogenase 2 family member ALDH2 HGNC:27683 ALK and LTK ligand 2 ALKAL2 AUGA HGNC:17911 alkB homolog 1, histone H2A dioxygenase ALKBH1 ABH alkB hABH HGNC:17377 allantoicase ALLC ALC HGNC:428 ALMS1 centrosome and basal body associated protein ALMS1 KIAA0328 HGNC:435 arachidonate 5-lipoxygenase ALOX5 5-LOX HGNC:436 arachidonate 5-lipoxygenase activating protein ALOX5AP FLAP HGNC:441 alkaline phosphatase, germ cell ALPG GCAP HGNC:437 alkaline phosphatase, intestinal ALPI IAP HGNC:20917 alpha kinase 1 ALPK1 FLJ22670 KIAA1527 Lak HGNC:438 alkaline phosphatase, biomineralization associated ALPL TNALP TNAP TNSALP HGNC:439 alkaline phosphatase, placental ALPP PALP PLAP HGNC:450 ALX homeobox 4 ALX4 FPP KIAA1788 PFM HGNC:468 adenosine monophosphate deaminase 1 AMPD1 MAD MADA HGNC:474 amylase alpha 1A AMY1A HGNC:22231 archaelysin family metallopeptidase 1 AMZ1 KIAA1950 HGNC:484 angiopoietin 1 ANGPT1 Ang1 KIAA0003 HGNC:485 angiopoietin 2 ANGPT2 Ang2 HGNC:490 angiopoietin like 2 ANGPTL2 ARP2 HARP HGNC:16039 angiopoietin like 4 ANGPTL4 ARP4 FIAF HFARP NL2 PGAR pp1158 HGNC:35240 ankyrin repeat domain 33B ANKRD33B HGNC:28233 ankyrin repeat domain 40 ANKRD40 MGC15396 HGNC:21625 anoctamin 1 ANO1 DOG1 FLJ10261 TAOS2 HGNC:543 annexin A5 ANXA5 HGNC:568 adaptor related protein complex 3 subunit delta 1 AP3D1 ADTD HGNC:16665 apelin APLN XNPEP2 apelin HGNC:339 apelin receptor APLNR APJ APJR FLJ90771 HGNC:600 apolipoprotein A1 APOA1 HGNC:601 apolipoprotein A2 APOA2 HGNC:17288 apolipoprotein A5 APOA5 APOA-V RAP3 HGNC:603 apolipoprotein B APOB HGNC:610 apolipoprotein C3 APOC3 HGNC:613 apolipoprotein E APOE HGNC:615 apolipoprotein F APOF HGNC:13916 apolipoprotein M APOM G3a NG20 HGNC:16029 aquaporin 10 AQP10 HGNC:638 aquaporin 5 AQP5 HGNC:663 arginase 1 ARG1 HGNC:16348 Rho GTPase activating protein 12 ARHGAP12 FLJ10971 FLJ20737 FLJ21785 HGNC:675 Rho GTPase activating protein 5 ARHGAP5 RhoGAP5 p190-B p190BRhoGAP HGNC:685 Rac/Cdc42 guanine nucleotide exchange factor 6 ARHGEF6 Cool-2 Cool2 KIAA0006 alpha-PIX alphaPIX HGNC:701 aryl hydrocarbon receptor nuclear translocator like ARNTL BMAL1 JAP3 MOP3 PASD3 bHLHe5 HGNC:726 ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) ART4 ARTC4 CD297 DOK1 HGNC:758 argininosuccinate synthase 1 ASS1 CTLN1 HGNC:13542 ATPase phospholipid transporting 10A (putative) ATP10A ATPVA ATPVC KIAA0566 HGNC:847 ATP synthase peripheral stalk subunit F6 ATP5PF CF6 HGNC:894 arginine vasopressin AVP ADH HGNC:905 AXL receptor tyrosine kinase AXL ARK JTK11 Tyro7 UFO HGNC:913 azurocidin 1 AZU1 AZAMP AZU CAP37 HBP HUMAZUR NAZC HGNC:918 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) B3GALNT1 GLOB P1 beta3Gal-T3 galT3 HGNC:13528 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 B3GNT3 B3GN-T3 B3GNT-3 HP10328 beta3Gn-T3 HGNC:21649 BAR/IMD domain containing adaptor protein 2 like 1 BAIAP2L1 IRTKS HGNC:43877 BRAF-activated non-protein coding RNA BANCR LINC00586 HGNC:983 butyrylcholinesterase BCHE E1 HGNC:1030 bradykinin receptor B2 BDKRB2 BK-2 HGNC:1033 brain derived neurotrophic factor BDNF HGNC:20871 BEN domain containing 6 BEND6 FLJ30162 bA203B9.1 HGNC:1043 bone gamma-carboxyglutamate protein BGLAP OCN HGNC:33584 BICD family like cargo adaptor 2 BICDL2 HGNC:1069 bone morphogenetic protein 2 BMP2 HGNC:1071 bone morphogenetic protein 4 BMP4 HGNC:1084 BCL2 interacting protein 3 BNIP3 Nip3 HGNC:16178 BPI fold containing family B member 3 BPIFB3 LPLUNC3 RYA3 dJ726C3.4 HGNC:26019 3'(2'), 5'-bisphosphate nucleotidase 2 BPNT2 FLJ20421 IMPA3 gPAPP HGNC:1099 BRCA1 associated protein BRAP BRAP2 IMP RNF52 HGNC:11551 BRF1 RNA polymerase III transcription initiation factor subunit BRF1 BRF TFIIIB90 hBRF HGNC:22393 BMP/retinoic acid inducible neural specific 3 BRINP3 DBCCR1L DBCCR1L1 HGNC:1116 basigin (Ok blood group) BSG CD147 EMMPRIN EMPRIN HGNC:20450 brain specific homeobox BSX BSX1 HGNC:1131 BTG anti-proliferation factor 2 BTG2 APRO1 MGC126063 MGC126064 PC3 TIS21 HGNC:1136 butyrophilin subfamily 2 member A1 BTN2A1 BT2.1 BTF1 BTN2.1 HGNC:1152 blood vessel epicardial substance BVES HBVES POP1 POPDC1 HGNC:26967 chromosome 12 open reading frame 56 C12orf56 HGNC:20346 chromosome 14 open reading frame 132 C14orf132 HGNC:1241 complement C1q A chain C1QA HGNC:14324 C1q and TNF related 1 C1QTNF1 CTRP1 FLJ90694 GIP ZSIG37 HGNC:33627 C2 calcium dependent domain containing 4A C2CD4A NLF1 HGNC:1318 complement C3 C3 ARMD9 C3a C3b CPAMD1 HGNC:1323 complement C4A (Rodgers blood group) C4A C4 C4A2 C4A3 C4A4 C4A6 C4B C4S CO4 CPAMD2 RG HGNC:1324 complement C4B (Chido blood group) C4B C4B1 C4B3 C4F CH CO4 CPAMD3 HGNC:34437 chromosome 4 open reading frame 48 C4orf48 HGNC:1331 complement C5 C5 C5a C5b CPAMD4 HGNC:1338 complement C5a receptor 1 C5AR1 C5A C5AR CD88 HGNC:4527 complement component 5a receptor 2 C5AR2 C5L2 HGNC:21703 chromosome 7 open reading frame 25 C7orf25 MGC2821 HGNC:51258 chromosome 8 open reading frame 89 C8orf89 HGNC:27037 chromosome 9 open reading frame 57 C9orf57 HGNC:1375 carbonic anhydrase 4 CA4 CAIV Car4 HGNC:1395 calcium voltage-gated channel subunit alpha1 H CACNA1H Cav3.2 HGNC:29938 cactin, spliceosome C complex subunit CACTIN NY-REN-24 fSAPc HGNC:1437 calcitonin related polypeptide alpha CALCA CGRP CGRP-alpha HGNC:29912 calcium binding and coiled-coil domain 2 CALCOCO2 MGC17318 NDP52 HGNC:1461 calcium/calmodulin dependent protein kinase II beta CAMK2B CAM2 CAMK2 CaMKII尾 HGNC:1472 cathelicidin antimicrobial peptide CAMP CAP18 FALL-39 FALL39 LL37 HGNC:55342 CAMTA2 antisense RNA 1 CAMTA2-AS1 HGNC:16422 caspase recruitment domain family member 10 CARD10 BIMP1 CARMA3 HGNC:1499 caspase 1 CASP1 ICE HGNC:1514 calcium sensing receptor CASR FHH GPRC2A NSHPT HGNC:1516 catalase CAT HGNC:1527 caveolin 1 CAV1 HGNC:9688 caveolae associated protein 1 CAVIN1 CGL4 cavin-1 HGNC:10690 caveolae associated protein 2 CAVIN2 PS-p68 SDR cavin-2 HGNC:28617 CACN subunit beta associated regulatory protein CBARP BARP DOS MGC40084 HGNC:1543 cerebellin 1 precursor CBLN1 HGNC:26514 CCDC140 long non-coding RNA CCDC140 FLJ32447 HGNC:53438 coiled-coil domain containing 194 CCDC194 HGNC:19967 coiled-coil domain containing 88C CCDC88C DAPLE HkRP2 SCA40 HGNC:10610 C-C motif chemokine ligand 11 CCL11 MGC22554 eotaxin HGNC:10618 C-C motif chemokine ligand 2 CCL2 GDCF-2 HC11 MCAF MCP-1 MCP1 MGC9434 SMC-CF HGNC:10627 C-C motif chemokine ligand 3 CCL3 G0S19-1 LD78ALPHA MIP-1-alpha HGNC:10632 C-C motif chemokine ligand 5 CCL5 MGC17164 RANTES SISd TCP228 HGNC:10634 C-C motif chemokine ligand 7 CCL7 FIC MARC MCP-3 MCP3 NC28 HGNC:2500 cellular communication network factor 2 CCN2 IGFBP8 HGNC:12769 cellular communication network factor 4 CCN4 WISP-1 HGNC:1602 C-C motif chemokine receptor 1 CCR1 CD191 CKR-1 MIP1aR HGNC:1603 C-C motif chemokine receptor 2 CCR2 CC-CKR-2 CD192 CKR2 FLJ78302 MCP-1-R HGNC:1606 C-C motif chemokine receptor 5 CCR5 CC-CKR-5 CD195 CKR-5 CKR5 IDDM22 HGNC:1608 C-C motif chemokine receptor 7 CCR7 BLR2 CD197 CDw197 HGNC:1628 CD14 molecule CD14 HGNC:11922 CD27 molecule CD27 S152 Tp55 HGNC:1663 CD36 molecule CD36 FAT GP3B GP4 GPIV SCARB3 HGNC:11919 CD40 molecule CD40 Bp50 p50 HGNC:11935 CD40 ligand CD40LG CD154 CD40L TRAP gp39 hCD40L HGNC:1692 CD63 molecule CD63 ME491 TSPAN30 HGNC:1693 CD68 molecule CD68 DKFZp686M18236 GP110 LAMP4 SCARD1 macrosialin HGNC:15855 CD93 molecule CD93 C1qR(P) C1qRP CDw93 ECSM3 dJ737E23.1 HGNC:16783 cell division cycle 73 CDC73 FIHP parafibromin HGNC:24357 CUB domain containing protein 1 CDCP1 CD318 SIMA135 HGNC:1753 cadherin 13 CDH13 CDHH HGNC:1759 cadherin 2 CDH2 CD325 CDHN HGNC:1763 cadherin 4 CDH4 HGNC:1764 cadherin 5 CDH5 7B4 CD144 HGNC:1767 cadherin 8 CDH8 HGNC:1785 cyclin dependent kinase inhibitor 1B CDKN1B KIP1 P27KIP1 HGNC:1786 cyclin dependent kinase inhibitor 1C CDKN1C KIP2 P57 HGNC:1788 cyclin dependent kinase inhibitor 2B CDKN2B CDK4I INK4B MTS2 P15 TP15 p15INK4b HGNC:34341 CDKN2B antisense RNA 1 CDKN2B-AS1 ANRIL CDKN2B-AS NCRNA00089 PCAT12 RP11-145E5.4 p15AS HGNC:48926 CDR1 antisense RNA CDR1-AS CDR1NAT CDR1as ciRS-7 HGNC:1806 caudal type homeobox 2 CDX2 HGNC:14015 CUGBP Elav-like family member 4 CELF4 HGNC:3231 cadherin EGF LAG seven-pass G-type receptor 2 CELSR2 ADGRC2 CDHF10 Flamingo1 KIAA0279 MEGF3 HGNC:3230 cadherin EGF LAG seven-pass G-type receptor 3 CELSR3 ADGRC3 CDHF11 FMI1 HFMI1 MEGF2 HGNC:11869 cell migration inducing hyaluronidase 2 CEMIP2 HGNC:14253 ceramide synthase 1 CERS1 LAG1 UOG1 HGNC:1863 carboxylesterase 1 CES1 CEH CES1A1 CES1A2 CES2 HMSE HMSE1 SES1 HGNC:1869 cholesteryl ester transfer protein CETP BPIFF HGNC:25247 cilia and flagella associated protein 46 CFAP46 DKFZp434A1721 FLJ25954 bA288G11.4 bA288G11.5 bB137A17.2 bB137A17.3 HGNC:24010 cilia and flagella associated protein 91 CFAP91 AAT-1 AAT1 AAT1alpha CaM-IP2 SPATA26 HGNC:4883 complement factor H CFH ARMD4 ARMS1 FHL1 HUS HGNC:1876 CASP8 and FADD like apoptosis regulator CFLAR CASH CLARP Casper FLAME FLIP I-FLICE MRIT c-FLIP cFLIP HGNC:25931 cingulin like 1 CGNL1 FLJ14957 JACOP KIAA1749 PCING HGNC:53620 cardiac hypertrophy associated epigenetic regulator 1 CHAER1 Chaer HGNC:1929 chromogranin A CHGA HGNC:1932 chitinase 3 like 1 CHI3L1 GP39 YK-40 YKL40 HGNC:1950 cholinergic receptor muscarinic 1 CHRM1 HGNC:1951 cholinergic receptor muscarinic 2 CHRM2 HGNC:1959 cholinergic receptor nicotinic alpha 5 subunit CHRNA5 HGNC:1962 cholinergic receptor nicotinic beta 2 subunit CHRNB2 HGNC:7067 class II major histocompatibility complex transactivator CIITA C2TA NLRA HGNC:20365 CLOCK interacting pacemaker CIPC HGNC:1982 cold inducible RNA binding protein CIRBP CIRP HGNC:1991 creatine kinase B CKB HGNC:1994 creatine kinase, M-type CKM HGNC:31736 creatine kinase, mitochondrial 1A CKMT1A HGNC:1995 creatine kinase, mitochondrial 1B CKMT1B UMTCK HGNC:1996 creatine kinase, mitochondrial 2 CKMT2 SMTCK HGNC:2034 claudin 12 CLDN12 HGNC:2036 claudin 15 CLDN15 HGNC:29013 C-type lectin domain containing 16A CLEC16A Gop-1 HGNC:34522 C-type lectin domain containing 19A CLEC19A HGNC:11891 C-type lectin domain family 3 member B CLEC3B TN HGNC:14555 C-type lectin domain family 4 member E CLEC4E mincle HGNC:24314 CAP-Gly domain containing linker protein 3 CLIP3 CLIPR-59 RSNL1 HGNC:2082 clock circadian regulator CLOCK KAT13D KIAA0334 bHLHe8 HGNC:2095 clusterin CLU CLU1 CLU2 KUB1 SGP-2 SP-40 TRPM-2 HGNC:2150 cyclic nucleotide gated channel subunit alpha 3 CNGA3 CCNC1 CCNCa CNG3 HGNC:103 cyclin and CBS domain divalent metal cation transport mediator 2 CNNM2 HGNC:2190 collagen type XIII alpha 1 chain COL13A1 HGNC:2195 collagen type XVIII alpha 1 chain COL18A1 KNO1 KS HGNC:2197 collagen type I alpha 1 chain COL1A1 OI4 HGNC:2198 collagen type I alpha 2 chain COL1A2 HGNC:22986 collagen type XXVII alpha 1 chain COL27A1 FLJ11895 KIAA1870 MGC11337 HGNC:2201 collagen type III alpha 1 chain COL3A1 HGNC:2202 collagen type IV alpha 1 chain COL4A1 HGNC:2203 collagen type IV alpha 2 chain COL4A2 DKFZp686I14213 FLJ22259 HGNC:2212 collagen type VI alpha 2 chain COL6A2 HGNC:17213 collectin subfamily member 11 COLEC11 CL-K1 MGC3279 HGNC:16223 COMM domain containing 7 COMMD7 dJ1085F17.3 HGNC:2227 cartilage oligomeric matrix protein COMP MED THBS5 HGNC:2228 catechol-O-methyltransferase COMT HGNC:19012 corin, serine peptidase CORIN ATC2 CRN Lrp4 PRSC TMPRSS10 HGNC:2295 ceruloplasmin CP HGNC:2300 carboxypeptidase B2 CPB2 CPU PCPB TAFI HGNC:2316 copine 3 CPNE3 HGNC:33632 cleavage and polyadenylation specific factor 4 like CPSF4L HGNC:2334 complement C3b/C4b receptor 1 (Knops blood group) CR1 CD35 KN HGNC:2342 carnitine O-acetyltransferase CRAT CAT1 HGNC:2358 corticotropin releasing hormone receptor 2 CRHR2 CRF-RB CRF2 HM-CRF HGNC:2367 C-reactive protein CRP PTX1 HGNC:14882 cartilage acidic protein 1 CRTAC1 ASPIC1 CEP-68 FLJ10320 HGNC:2385 cryptochrome circadian regulator 2 CRY2 HGNC:2432 colony stimulating factor 1 CSF1 M-CSF MCSF MGC31930 HGNC:2475 cystatin C CST3 HGNC:2499 cardiotrophin 1 CTF1 CT-1 CT1 HGNC:2505 cytotoxic T-lymphocyte associated protein 4 CTLA4 CD CD152 CTLA-4 GSE HGNC:2514 catenin beta 1 CTNNB1 armadillo beta-catenin HGNC:2529 cathepsin D CTSD CLN10 HGNC:2545 cathepsin S CTSS HGNC:15679 cortactin binding protein 2 CTTNBP2 KIAA1758 Orf4 HGNC:10647 C-X3-C motif chemokine ligand 1 CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN HGNC:2558 C-X3-C motif chemokine receptor 1 CX3CR1 CCRL1 CMKDR1 V28 HGNC:10637 C-X-C motif chemokine ligand 10 CXCL10 C7 IFI10 IP-10 crg-2 gIP-10 mob-1 HGNC:10672 C-X-C motif chemokine ligand 12 CXCL12 PBSF SCYB12 SDF-1a SDF-1b TLSF-a TLSF-b TPAR1 HGNC:16642 C-X-C motif chemokine ligand 16 CXCL16 CXCLG16 SR-PSOX SRPSOX HGNC:6025 C-X-C motif chemokine ligand 8 CXCL8 3-10C AMCF-I GCP-1 GCP1 IL-8 K60 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 SCYB8 TSG-1 b-ENAP HGNC:2561 C-X-C motif chemokine receptor 4 CXCR4 CD184 D2S201E HM89 HSY3RR LESTR NPY3R NPYR NPYY3R fusin HGNC:2577 cytochrome b-245 alpha chain CYBA p22-PHOX HGNC:2578 cytochrome b-245 beta chain CYBB GP91-PHOX NOX2 HGNC:19986 cytochrome c, somatic CYCS CYC HCS HGNC:2596 cytochrome P450 family 1 subfamily A member 2 CYP1A2 CP12 P3-450 HGNC:20581 cytochrome P450 family 26 subfamily B member 1 CYP26B1 P450RAI-2 HGNC:2621 cytochrome P450 family 2 subfamily C member 19 CYP2C19 CPCJ P450IIC19 HGNC:2622 cytochrome P450 family 2 subfamily C member 8 CYP2C8 CPC8 HGNC:2623 cytochrome P450 family 2 subfamily C member 9 CYP2C9 P450IIC9 HGNC:2625 cytochrome P450 family 2 subfamily D member 6 CYP2D6 CPD6 CYP2D P450-DB1 P450C2D HGNC:2634 cytochrome P450 family 2 subfamily J member 2 CYP2J2 HGNC:20580 cytochrome P450 family 2 subfamily R member 1 CYP2R1 HGNC:2638 cytochrome P450 family 3 subfamily A member 5 CYP3A5 CP35 P450PCN3 PCN3 HGNC:2642 cytochrome P450 family 4 subfamily A member 11 CYP4A11 CYP4AII HGNC:2645 cytochrome P450 family 4 subfamily F member 2 CYP4F2 HGNC:2651 cytochrome P450 family 7 subfamily A member 1 CYP7A1 HGNC:2674 death associated protein kinase 1 DAPK1 DAPK ROCO3 HGNC:2701 DCC netrin 1 receptor DCC IGDCC1 NTN1R1 HGNC:2710 dCMP deaminase DCTD HGNC:2716 dimethylarginine dimethylaminohydrolase 2 DDAH2 G6A HGNC:13917 DExD-box helicase 39B DDX39B D6S81E UAP56 HGNC:2843 diacylglycerol O-acyltransferase 1 DGAT1 ARGP1 HGNC:2859 24-dehydrocholesterol reductase DHCR24 KIAA0018 seladin-1 HGNC:2883 iodothyronine deiodinase 1 DIO1 HGNC:2884 iodothyronine deiodinase 2 DIO2 SelY TXDI2 HGNC:29150 disco interacting protein 2 homolog C DIP2C HGNC:2888 DISC1 scaffold protein DISC1 HGNC:2893 dickkopf WNT signaling pathway inhibitor 3 DKK3 REIC RIG HGNC:2897 DLC1 Rho GTPase activating protein DLC1 ARHGAP7 DLC-1 HP STARD12 p122-RhoGAP HGNC:24476 DLG associated protein 4 DLGAP4 DAP4 KIAA0964 SAPAP4 HGNC:13908 DMRT like family A2 DMRTA2 HGNC:2939 DNA replication helicase/nuclease 2 DNA2 KIAA0083 HGNC:5229 DnaJ heat shock protein family (Hsp40) member A1 DNAJA1 HSPF4 NEDD7 dj-2 hdj-2 HGNC:13192 DnaJ heat shock protein family (Hsp40) member C2 DNAJC2 MPHOSPH11 MPP11 ZUO1 zuotin HGNC:2956 deoxyribonuclease 1 DNASE1 HGNC:2960 deoxyribonuclease 2, lysosomal DNASE2 HGNC:23476 dedicator of cytokinesis 5 DOCK5 FLJ21034 HGNC:24948 DOT1 like histone lysine methyltransferase DOT1L DOT1 KIAA1814 KMT4 HGNC:17427 double PHD fingers 3 DPF3 BAF45c Cerd4 FLJ14079 cer-d4 HGNC:3009 dipeptidyl peptidase 4 DPP4 DPPIV HGNC:18648 dipeptidyl peptidase 9 DPP9 HGNC:3016 dihydropyrimidinase like 4 DPYSL4 CRMP3 DRP-4 ULIP4 HGNC:3020 dopamine receptor D1 DRD1 HGNC:37261 death domain containing 1 DTHD1 FLJ16686 HGNC:3068 dual specificity phosphatase 2 DUSP2 PAC-1 HGNC:3097 dysferlin DYSF FER1L1 HGNC:19087 EBF transcription factor 3 EBF3 COE3 DKFZp667B0210 HGNC:3176 endothelin 1 EDN1 ET1 HGNC:3179 endothelin receptor type A EDNRA ET-A ETA-R hET-AR HGNC:3226 ephrin B1 EFNB1 Elk-L LERK2 HGNC:14661 egl-9 family hypoxia inducible factor 3 EGLN3 HIFPH3 PHD3 HGNC:3243 EH domain containing 2 EHD2 HGNC:32961 EP300 interacting inhibitor of differentiation 3 EID3 FLJ25832 NSE4B NSMCE4B HGNC:18138 eukaryotic translation initiation factor 3 subunit L EIF3L EIF3S11 HSPC021 HSPC025 HGNC:3290 eukaryotic translation initiation factor 4E binding protein 3 EIF4EBP3 4E-BP3 HGNC:3309 elastase, neutrophil expressed ELANE HLE HNE NE HGNC:3315 ELAV like RNA binding protein 4 ELAVL4 PNEM HGNC:3330 EMAP like 1 EML1 ELP79 EMAP HuEMAP HGNC:3340 empty spiracles homeobox 1 EMX1 HGNC:3342 engrailed homeobox 1 EN1 HGNC:3349 endoglin ENG CD105 END HHT1 HGNC:24838 energy homeostasis associated ENHO UNQ470 HGNC:3354 enolase 3 ENO3 HGNC:3356 ectonucleotide pyrophosphatase/phosphodiesterase 1 ENPP1 PC-1 PCA1 ENSG00000230606 APPAT ENST00000620272 HGNC:3386 EPH receptor A2 EPHA2 HGNC:3415 erythropoietin EPO EP HGNC:3432 erb-b2 receptor tyrosine kinase 4 ERBB4 ALS19 HER4 HGNC:17474 endothelial cell adhesion molecule ESAM W117m HGNC:3466 endothelial cell specific molecule 1 ESM1 HGNC:27937 espin like ESPNL FLJ42568 HGNC:3467 estrogen receptor 1 ESR1 ER-alpha Era NR3A1 HGNC:3468 estrogen receptor 2 ESR2 ER-beta Erb NR3A2 HGNC:3474 estrogen related receptor gamma ESRRG ERR-gamma ERRg NR3B3 HGNC:3529 coagulation factor XI F11 FXI HGNC:3530 coagulation factor XII F12 HGNC:3531 coagulation factor XIII A chain F13A1 HGNC:3534 coagulation factor XIII B chain F13B FXIIIB HGNC:3535 coagulation factor II, thrombin F2 HGNC:3537 coagulation factor II thrombin receptor F2R CF2R PAR-1 PAR1 TR HGNC:3538 F2R like trypsin receptor 1 F2RL1 PAR2 HGNC:3541 coagulation factor III, tissue factor F3 CD142 TF HGNC:3542 coagulation factor V F5 HGNC:3544 coagulation factor VII F7 HGNC:3553 fatty acid amide hydrolase FAAH FAAH-1 HGNC:3556 fatty acid binding protein 2 FABP2 I-FABP HGNC:3557 fatty acid binding protein 3 FABP3 H-FABP O-FABP HGNC:3559 fatty acid binding protein 4 FABP4 A-FABP aP2 HGNC:17067 Fas apoptotic inhibitory molecule 2 FAIM2 KIAA0950 LFG LFG2 LIFEGUARD NMP35 TMBIM2 HGNC:28587 family with sequence similarity 110 member B FAM110B MGC39325 HGNC:21109 family with sequence similarity 120B FAM120B CCPG PGCC1 SAN1 HGNC:23522 family with sequence similarity 171 member A1 FAM171A1 APCN FLJ12884 HGNC:21362 family with sequence similarity 217 member A FAM217A MGC43581 HGNC:25278 family with sequence similarity 71 member E2 FAM71E2 DKFZp434G1729 HGNC:3584 FA complementation group C FANCC FA3 FAC HGNC:3590 fibroblast activation protein alpha FAP DPPIV HGNC:11920 Fas cell surface death receptor FAS APO-1 CD95 HGNC:3600 fibulin 1 FBLN1 FBLN HGNC:3602 fibulin 5 FBLN5 ARMD3 DANCE EVEC UP50 HGNC:26740 fibulin 7 FBLN7 FLJ37440 TM14 HGNC:24679 F-box and leucine rich repeat protein 20 FBXL20 Fbl2 Fbl20 MGC15482 HGNC:3608 Fc fragment of IgA receptor FCAR CD89 HGNC:3624 ficolin 2 FCN2 EBP-37 FCNL P35 ficolin-2 HGNC:23151 fermitin family member 3 FERMT3 KIND3 MGC10966 MIG-2 MIG2B UNC112C URP2 HGNC:3658 fetuin B FETUB HGNC:22788 FEZ family zinc finger 1 FEZF1 HGNC:13506 FEZ family zinc finger 2 FEZF2 FEZL FKSG36 FLJ10142 TOF Zfp312 HGNC:4501 free fatty acid receptor 2 FFAR2 FFA2R HGNC:3661 fibrinogen alpha chain FGA HGNC:3662 fibrinogen beta chain FGB HGNC:3675 fibroblast growth factor 19 FGF19 HGNC:3676 fibroblast growth factor 2 FGF2 HGNC:3678 fibroblast growth factor 21 FGF21 HGNC:3680 fibroblast growth factor 23 FGF23 HGNC:3694 fibrinogen gamma chain FGG HGNC:3721 FKBP prolyl isomerase 5 FKBP5 FKBP51 FKBP54 P54 PPIase Ptg-10 HGNC:3763 fms related receptor tyrosine kinase 1 FLT1 VEGFR1 HGNC:3767 fms related receptor tyrosine kinase 4 FLT4 PCL VEGFR-3 VEGFR3 HGNC:18267 formin like 2 FMNL2 KIAA1902 HGNC:3778 fibronectin 1 FN1 CIG FINC GFND2 LETS MSF HGNC:20240 fibronectin type III domain containing 5 FNDC5 FRCP2 HGNC:3788 folate hydrolase 1 FOLH1 GCP2 GCPII NAALAD1 NAALAdase PSM PSMA HGNC:3800 forkhead box C1 FOXC1 ARA FREAC3 IGDA IHG1 HGNC:3803 forkhead box D2 FOXD2 FREAC9 HGNC:20367 FRY microtubule binding protein FRY 13CDNA73 CG003 bA37E23.1 HGNC:3972 follistatin like 1 FSTL1 FRP FSL1 OCC-1 OCC1 tsc36 HGNC:24678 FTO alpha-ketoglutarate dependent dioxygenase FTO ALKBH9 KIAA1752 MGC5149 HGNC:8568 furin, paired basic amino acid cleaving enzyme FURIN SPC1 HGNC:3951 frataxin FXN CyaY FA FARR X25 HGNC:4079 gamma-aminobutyric acid type A receptor subunit alpha5 GABRA5 HGNC:4087 gamma-aminobutyric acid type A receptor subunit gamma2 GABRG2 HGNC:4088 gamma-aminobutyric acid type A receptor subunit gamma3 GABRG3 HGNC:24869 galactose-3-O-sulfotransferase 2 GAL3ST2 GP3ST HGNC:33844 polypeptide N-acetylgalactosaminyltransferase like 6 GALNTL6 GALNT17 GalNAc-T6L HGNC:16955 growth arrest specific 2 like 1 GAS2L1 GAR22 HGNC:4164 gastrin GAST HGNC:4173 GATA binding protein 4 GATA4 HGNC:15802 GATA binding protein 5 GATA5 GATAS bB379O24.1 HGNC:4174 GATA binding protein 6 GATA6 HGNC:4187 GC vitamin D binding protein GC DBP VDBP hDBP HGNC:4311 glutamate-cysteine ligase catalytic subunit GCLC GCS HGNC:4312 glutamate-cysteine ligase modifier subunit GCLM HGNC:30142 growth differentiation factor 15 GDF15 MIC-1 MIC1 NAG-1 PDF PLAB PTGFB HGNC:4221 growth differentiation factor 6 GDF6 BMP13 KFS KFS1 HGNC:4222 growth differentiation factor 7 GDF7 BMP12 HGNC:4232 glial cell derived neurotrophic factor GDNF ATF1 ATF2 HFB1-GDNF HGNC:4250 gamma-glutamyltransferase 1 GGT1 CD224 D22S672 D22S732 HGNC:4261 growth hormone 1 GH1 GH GH-N GHN hGH-N HGNC:4263 growth hormone receptor GHR GHBP HGNC:18129 ghrelin and obestatin prepropeptide GHRL MTLRP ghrelin obestatin HGNC:4267 growth hormone secretagogue receptor GHSR HGNC:4278 gap junction protein alpha 4 GJA4 CX37 HGNC:4279 gap junction protein alpha 5 GJA5 CX40 HGNC:4313 glycine decarboxylase GLDC GCSP NKH HGNC:28592 GLIPR1 like 2 GLIPR1L2 MGC39497 HGNC:4324 glucagon like peptide 1 receptor GLP1R GLP-1R HGNC:4371 glucocorticoid modulatory element binding protein 2 GMEB2 KIAA1269 P79PIF PIF79 HGNC:24872 GNAS antisense RNA 1 GNAS-AS1 GNAS1AS NCRNA00075 NESP-AS NESPAS SANG HGNC:4400 G protein subunit beta 3 GNB3 HGNC:14131 G protein subunit gamma 13 GNG13 G(gamma)13 h2-35 HGNC:13567 golgin A6 family member A GOLGA6A GLP HGNC:4431 golgi SNAP receptor complex member 2 GOSR2 Bos1 GS27 HGNC:4432 glutamic-oxaloacetic transaminase 1 GOT1 AST1 HGNC:4433 glutamic-oxaloacetic transaminase 2 GOT2 KAT4 KATIV KYAT4 mitAAT HGNC:4439 glycoprotein Ib platelet subunit alpha GP1BA CD42b GPIbalpha HGNC:4443 glycoprotein V platelet GP5 CD42d HGNC:14388 glycoprotein VI platelet GP6 GPVI HGNC:4454 glypican 6 GPC6 HGNC:14963 G protein-coupled receptor 101 GPR101 HGNC:23689 G protein-coupled receptor 158 GPR158 KIAA1136 HGNC:23693 G protein-coupled receptor 160 GPR160 GPCR1 GPCR150 HGNC:4475 G protein-coupled receptor 20 GPR20 HGNC:17858 G protein signaling modulator 1 GPSM1 AGS3 DKFZP727I051 HGNC:4552 glutamic--pyruvic transaminase GPT ALT1 GPT1 HGNC:18062 glutamic--pyruvic transaminase 2 GPT2 ALT2 HGNC:4555 glutathione peroxidase 3 GPX3 HGNC:29113 GRAM domain containing 4 GRAMD4 DIP KIAA0767 HGNC:25839 grainyhead like transcription factor 3 GRHL3 SOM HGNC:289 G protein-coupled receptor kinase 2 GRK2 BARK1 HGNC:290 G protein-coupled receptor kinase 3 GRK3 BARK2 HGNC:4543 G protein-coupled receptor kinase 4 GRK4 GPRK4 HGNC:4594 glutamate metabotropic receptor 2 GRM2 GPRC1B MGLUR2 mGlu2 HGNC:4595 glutamate metabotropic receptor 3 GRM3 GPRC1C MGLUR3 mGlu3 HGNC:4612 goosecoid homeobox GSC HGNC:2810 gasdermin E GSDME ICERE-1 HGNC:4632 glutathione S-transferase mu 1 GSTM1 H-B MU HGNC:13312 glutathione S-transferase omega 1 GSTO1 GSTTLp28 P28 HGNC:4638 glutathione S-transferase pi 1 GSTP1 GSTP HGNC:4641 glutathione S-transferase theta 1 GSTT1 HGNC:26930 glutathione S-transferase theta 4 GSTT4 HS322B1A HGNC:21535 GTP binding protein 4 GTPBP4 CRFG FLJ10686 FLJ10690 NGB NOG1 HGNC:30189 GTP binding protein 6 (putative) GTPBP6 FLJ20977 PGPL HGNC:4709 granzyme B GZMB CCPI CGL-1 CGL1 CSP-B CTSGL1 HLP SECT HGNC:4713 H19 imprinted maternally expressed transcript H19 ASM ASM1 D11S813E LINC00008 MIR675HG NCRNA00008 HGNC:15598 hepcidin antimicrobial peptide HAMP HEPC HFE2B LEAP-1 LEAP1 HGNC:4808 heart and neural crest derivatives expressed 2 HAND2 Hed Thing2 bHLHa26 dHand HGNC:4816 histidyl-tRNA synthetase 1 HARS1 HisRS HGNC:30532 HAUS augmin like complex subunit 8 HAUS8 MGC20533 NY-SAR-48 HGNC:17866 hepatitis A virus cellular receptor 1 HAVCR1 CD365 HAVCR HAVCR-1 KIM1 TIM-1 TIM1 TIMD1 HGNC:3059 heparin binding EGF like growth factor HBEGF HGNC:4831 hemoglobin subunit gamma 1 HBG1 HBG-T2 HGNC:4832 hemoglobin subunit gamma 2 HBG2 HBG-T1 HGNC:19086 histone deacetylase 11 HDAC11 HGNC:14063 histone deacetylase 4 HDAC4 HA6116 HD4 HDAC-4 HDAC-A HDACA KIAA0288 HGNC:14065 histone deacetylase 9 HDAC9 HD7 HDAC HDAC7B KIAA0744 MITR HGNC:14680 HDGF like 2 HDGFL2 HRP2 Hdgfrp2 HGNC:5192 hes family bHLH transcription factor 1 HES1 FLJ20408 HES-1 bHLHb39 HGNC:4886 homeostatic iron regulator HFE HFE1 HLA-H HGNC:4893 hepatocyte growth factor HGF F-TCF HGFB HPTA SF HGNC:19710 HHIP like 1 HHIPL1 HGNC:4910 hypoxia inducible factor 1 subunit alpha HIF1A HIF-1alpha HIF1 MOP1 PASD8 bHLHe78 HGNC:43015 HIF1A antisense RNA 2 HIF1A-AS2 3'aHIF-1A aHIF HGNC:4920 HIVEP zinc finger 1 HIVEP1 CIRIP CRYBP1 MBP-1 PRDII-BF1 Schnurri-1 ZAS1 ZNF40A HGNC:4948 major histocompatibility complex, class II, DR beta 1 HLA-DRB1 HGNC:19194 hemicentin 1 HMCN1 FBLN6 FIBL-6 FIBL6 HGNC:5010 high mobility group AT-hook 1 HMGA1 HGNC:4983 high mobility group box 1 HMGB1 DKFZp686A04236 HMG3 SBP-1 HGNC:5006 3-hydroxy-3-methylglutaryl-CoA reductase HMGCR HGNC:5013 heme oxygenase 1 HMOX1 HO-1 bK286B10 HGNC:11621 HNF1 homeobox A HNF1A HNF1 LFB1 HGNC:17011 heterogeneous nuclear ribonucleoprotein U like 1 HNRNPUL1 E1B-AP5 E1BAP5 FLJ12944 HGNC:33510 HOX transcript antisense RNA HOTAIR HOXC-AS4 HOXC11-AS1 NCRNA00072 HGNC:5130 homeobox C9 HOXC9 HGNC:5141 haptoglobin HP HGNC:15597 HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 HPS3 BLOC2S1 SUTAL HGNC:5164 heparanase HPSE HPA HPSE1 HSE1 HGNC:5237 heat shock protein family A (Hsp70) member 4 HSPA4 HS24/P52 HSPH2 HGNC:5246 heat shock protein family B (small) member 1 HSPB1 CMT2F HSP27 HSP28 Hs.76067 Hsp25 HGNC:5261 heat shock protein family D (Hsp60) member 1 HSPD1 GroEL HSP60 HGNC:16969 heat shock protein family H (Hsp110) member 1 HSPH1 HSP105A HSP105B KIAA0201 NY-CO-25 HGNC:5293 5-hydroxytryptamine receptor 2A HTR2A 5-HT2A HGNC:14348 HtrA serine peptidase 2 HTRA2 OMI PARK13 HGNC:16931 hypoxia up-regulated 1 HYOU1 Grp170 HSP12A ORP150 HGNC:5344 intercellular adhesion molecule 1 ICAM1 BB2 CD54 HGNC:5363 inhibitor of DNA binding 4, HLH protein ID4 bHLHb27 HGNC:5397 interferon alpha inducible protein 27 IFI27 FAM14D ISG12 P27 HGNC:5438 interferon gamma IFNG HGNC:5440 interferon gamma receptor 2 IFNGR2 AF-1 HGNC:5464 insulin like growth factor 1 IGF1 IGF IGF-I IGF1A IGFI HGNC:5469 insulin like growth factor binding protein 1 IGFBP1 AFBP IGF-BP25 PP12 hIGFBP-1 HGNC:5472 insulin like growth factor binding protein 3 IGFBP3 BP-53 IBP3 HGNC:5473 insulin like growth factor binding protein 4 IGFBP4 BP-4 HT29-IGFBP IBP4 IGFBP-4 HGNC:5522 immunoglobulin heavy constant epsilon IGHE HGNC:5541 immunoglobulin heavy constant mu IGHM HGNC:5962 interleukin 10 IL10 CSIF IL-10 IL10A TGIF HGNC:5969 interleukin 12A IL12A CLMF IL-12A NFSK p35 HGNC:5970 interleukin 12B IL12B CLMF CLMF2 IL-12B NKSF HGNC:5972 interleukin 12 receptor subunit beta 2 IL12RB2 HGNC:5973 interleukin 13 IL13 ALRH BHR1 IL-13 MGC116786 MGC116788 MGC116789 P600 HGNC:5980 interleukin 16 IL16 FLJ16806 FLJ42735 HsT19289 IL-16 LCF prIL-16 HGNC:5981 interleukin 17A IL17A IL-17 IL-17A HGNC:5985 interleukin 17 receptor A IL17RA CD217 CDw217 IL-17RA hIL-17R HGNC:5986 interleukin 18 IL18 IGIF IL-18 IL-1g IL1F4 HGNC:5990 interleukin 19 IL19 IL-10C IL-19 MDA1 NG.1 ZMDA1 HGNC:5992 interleukin 1 beta IL1B IL-1B IL1-BETA IL1F2 HGNC:15552 interleukin 1 family member 10 IL1F10 FKSG75 IL-1F10 IL-1HY2 IL1-theta MGC11983 MGC119832 MGC119833 HGNC:5994 interleukin 1 receptor type 2 IL1R2 CD121b HGNC:5995 interleukin 1 receptor accessory protein IL1RAP C3orf13 IL-1RAcP IL1R3 HGNC:5998 interleukin 1 receptor like 1 IL1RL1 DER4 FIT-1 IL33R ST2 ST2L ST2V T1 HGNC:6000 interleukin 1 receptor antagonist IL1RN ICIL-1RA IL-1RN IL1F3 IL1RA IRAP MGC10430 HGNC:6005 interleukin 21 IL21 IL-21 Za11 HGNC:19157 interleukin 27 IL27 IL-27 IL-27A IL27A IL27p28 MGC71873 p28 HGNC:6008 interleukin 2 receptor subunit alpha IL2RA CD25 HGNC:16830 interleukin 32 IL32 NK4 TAIF TAIFb TAIFd HGNC:16028 interleukin 33 IL33 DKFZp586H0523 DVS27 IL1F11 NF-HEV HGNC:28529 interleukin 34 IL34 IL-34 MGC34647 HGNC:15563 interleukin 37 IL37 FIL1 FIL1(ZETA) FIL1Z IL-1F7 IL-1H4 IL-1RP1 HGNC:6014 interleukin 4 IL4 BCGF-1 BCGF1 BSF1 IL-4 MGC79402 HGNC:6015 interleukin 4 receptor IL4R CD124 HGNC:6018 interleukin 6 IL6 BSF2 HGF HSF IL-6 HGNC:6019 interleukin 6 receptor IL6R CD126 HGNC:6021 interleukin 6 signal transducer IL6ST CD130 GP130 sGP130 HGNC:6023 interleukin 7 IL7 IL-7 HGNC:6038 interleukin enhancer binding factor 3 ILF3 DRBP76 MPHOSPH4 MPP4 MPP4110 NF110 NF110b NF90 NF90a NF90c NF90ctv NFAR-1 NFAR-2 NFAR110 NFAR90 TCP110 HGNC:6081 insulin INS HGNC:6091 insulin receptor INSR CD220 HGNC:22831 IQ motif containing with AAA domain 1 like IQCA1L TCAG_9762 HGNC:29059 IQ motif and Sec7 domain ArfGEF 2 IQSEC2 BRAG1 IQ-ArfGEF KIAA0522 HGNC:17020 interleukin 1 receptor associated kinase 3 IRAK3 IRAK-M HGNC:6125 insulin receptor substrate 1 IRS1 HIRS-1 HGNC:6126 insulin receptor substrate 2 IRS2 HGNC:14359 iroquois homeobox 2 IRX2 HGNC:6129 iroquois homeobox 4 IRX4 HGNC:30879 integrin alpha FG-GAP repeat containing 2 ITFG2 MDS028 HGNC:6137 integrin subunit alpha 2 ITGA2 CD49b HGNC:6138 integrin subunit alpha 2b ITGA2B CD41 CD41B PPP1R93 HGNC:6149 integrin subunit alpha M ITGAM CD11b MAC-1 HGNC:6156 integrin subunit beta 3 ITGB3 CD61 GPIIIa HGNC:6158 integrin subunit beta 4 ITGB4 CD104 HGNC:6168 inter-alpha-trypsin inhibitor heavy chain 3 ITIH3 H3P HGNC:18259 intelectin 1 ITLN1 FLJ20022 HL-1 ITLN LFR hIntL HGNC:6188 jagged canonical Notch ligand 1 JAG1 AHD AWS CD339 HJ1 HGNC:29283 junctional cadherin 5 associated JCAD HGNC:6206 JunD proto-oncogene, AP-1 transcription factor subunit JUND AP-1 HGNC:15904 lysine acetyltransferase 14 KAT14 ATAC2 CRP2BP PRO1194 dJ717M23.1 HGNC:29173 kazrin, periplakin interacting protein KAZN FLJ43806 KAZRIN KIAA1026 HGNC:29104 kelch repeat and BTB domain containing 11 KBTBD11 KIAA0711 KLHDC7C HGNC:6251 potassium voltage-gated channel subfamily H member 2 KCNH2 HERG Kv11.1 erg1 HGNC:18864 potassium voltage-gated channel subfamily H member 8 KCNH8 Kv12.1 elk3 HGNC:6266 potassium inwardly rectifying channel subfamily J member 5 KCNJ5 CIR GIRK4 KATP1 Kir3.4 LQT13 HGNC:6269 potassium inwardly rectifying channel subfamily J member 8 KCNJ8 Kir6.1 HGNC:6284 potassium calcium-activated channel subfamily M alpha 1 KCNMA1 KCa1.1 mSLO1 HGNC:6290 potassium calcium-activated channel subfamily N member 1 KCNN1 KCa2.1 hSK1 HGNC:6291 potassium calcium-activated channel subfamily N member 2 KCNN2 KCa2.2 hSK2 HGNC:6293 potassium calcium-activated channel subfamily N member 4 KCNN4 IK KCa3.1 hIKCa1 hKCa4 hSK4 HGNC:6295 KCNQ1 opposite strand/antisense transcript 1 KCNQ1OT1 KCNQ1-AS2 KvDMR1 KvLQT1-AS LIT1 NCRNA00012 HGNC:18249 potassium channel tetramerization domain containing 1 KCTD1 HGNC:6307 kinase insert domain receptor KDR CD309 FLK1 VEGFR VEGFR2 HGNC:21202 kinesin family member 6 KIF6 DKFZp451I2418 MGC33317 dJ1043E3.1 dJ137F1.4 dJ188D3.1 HGNC:6344 klotho KL HGNC:6357 kallikrein 1 KLK1 Klk6 HGNC:6364 kallikrein related peptidase 3 KLK3 PSA HGNC:6383 kininogen 1 KNG1 BK HGNC:34404 lysine rich nucleolar protein 1 KNOP1 101F10.1 FAM191A TSG118 HGNC:18594 L3MBTL histone methyl-lysine binding protein 2 L3MBTL2 DKFZP761I141 H-l(3)mbt-l dJ756G23.3 HGNC:6483 laminin subunit alpha 3 LAMA3 BM600-150kDa epiligrin kalinin-165kDa nicein-150kDa HGNC:6486 laminin subunit beta 1 LAMB1 HGNC:6501 lysosomal associated membrane protein 2 LAMP2 CD107b HGNC:6517 lipopolysaccharide binding protein LBP BPIFD2 HGNC:16960 ladybird homeobox 1 LBX1 HPX6 LBX1H HGNC:6526 lipocalin 2 LCN2 24p3 NGAL HGNC:6535 lactate dehydrogenase A LDHA HGNC:6541 lactate dehydrogenase B LDHB HGNC:6547 low density lipoprotein receptor LDLR LDLCQ2 HGNC:6553 leptin LEP HGNC:6554 leptin receptor LEPR CD295 OBR HGNC:49597 lymphatic endothelial transcriptional regulator lncRNA 1 LETR1 HGNC:6562 galectin 2 LGALS2 HL14 HGNC:6563 galectin 3 LGALS3 GALIG MAC-2 HGNC:6564 galectin 3 binding protein LGALS3BP 90K BTBD17B CyCAP M2BP MAC-2-BP TANGO10B gp90 HGNC:9472 legumain LGMN LGMN1 HGNC:6589 LHFPL tetraspan subfamily member 3 LHFPL3 HGNC:21253 LHFPL tetraspan subfamily member 5 LHFPL5 MGC33835 Tmhs dJ510O8.8 HGNC:30042 phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP HDHD2B HGNC:6598 DNA ligase 1 LIG1 HGNC:6613 LIM domain kinase 1 LIMK1 LIMK HGNC:26885 long intergenic non-protein coding RNA, p53 induced transcript LINC-PINT FLJ43663 LincRNA-Pint PINT HGNC:16189 long intergenic non-protein coding RNA 261 LINC00261 ALIEN DEANR1 FALCOR HCCDR1 TCONS_00027846 bA216C10.1 onco-lncRNA-17 HGNC:44354 long intergenic non-protein coding RNA 673 LINC00673 ERRLR01 HI-LNC75 SLNCR1 HGNC:50577 long intergenic non-protein coding RNA 1351 LINC01351 HGNC:6617 lipase A, lysosomal acid type LIPA CESD LAL HGNC:6619 lipase C, hepatic type LIPC HL HTGL HGNC:6623 lipase G, endothelial type LIPG EDL HGNC:6629 LLGL scribble cell polarity complex component 2 LLGL2 HGL Hugl-2 HGNC:6648 leiomodin 2 LMOD2 HGNC:28014 leukemia NUP98 fusion partner 1 LNP1 NP3 uncharacterized LOC147004 LOC147004 HGNC:6667 lipoprotein(a) LPA Lp(a) HGNC:21210 lipoprotein(a) like 2, pseudogene LPAL2 APOARGC HGNC:3166 lysophosphatidic acid receptor 1 LPAR1 GPR26 Gpcr26 LPA1 Mrec1.3 edg-2 rec.1.3 vzg-1 HGNC:6677 lipoprotein lipase LPL HGNC:29290 leucine rich repeat and fibronectin type III domain containing 1 LRFN1 KIAA1484 SALM2 HGNC:29480 leucine rich alpha-2-glycoprotein 1 LRG1 LRG HGNC:17360 leucine rich repeats and immunoglobulin like domains 1 LRIG1 DKFZP586O1624 LIG-1 LIG1 HGNC:6698 LDL receptor related protein 6 LRP6 ADCAD2 HGNC:6700 LDL receptor related protein 8 LRP8 APOER2 HSZ75190 LRP-8 MCI1 HGNC:6701 LDL receptor related protein associated protein 1 LRPAP1 HBP44 HGNC:30219 leucine rich repeat containing 30 LRRC30 HGNC:25965 leucine rich repeat containing 49 LRRC49 FLJ20156 HGNC:16914 leucine rich repeat neuronal 2 LRRN2 FIGLER7 GAC1 LRANK1 HGNC:25652 large 60S subunit nuclear export GTPase 1 LSG1 FLJ11301 HGNC:15887 LSM family member 14B LSM14B FLJ25473 FT005 LSM13 RAP55B bA11M20.3 HGNC:6709 lymphotoxin alpha LTA LT TNFSF1 HGNC:6710 leukotriene A4 hydrolase LTA4H HGNC:6714 latent transforming growth factor beta binding protein 1 LTBP1 HGNC:6717 latent transforming growth factor beta binding protein 4 LTBP4 FLJ46318 FLJ90018 LTBP-4 LTBP-4L HGNC:6727 lymphocyte antigen 6 family member E LY6E RIG-E SCA-2 TSA-1 HGNC:26397 LY6/PLAUR domain containing 5 LYPD5 FLJ30469 HGNC:30502 lysozyme like 1 LYZL1 LYC2 MGC33408 HGNC:29381 leucine zipper tumor suppressor 2 LZTS2 KIAA1813 LAPSER1 HGNC:6762 mitotic arrest deficient 1 like 1 MAD1L1 HsMAD1 MAD1 PIG9 TP53I9 TXBP181 HGNC:24934 MAGE family member E1 MAGEE1 DAMAGE KIAA1587 HGNC:13634 mal, T cell differentiation protein 2 MAL2 HGNC:29665 metastasis associated lung adenocarcinoma transcript 1 MALAT1 HCN LINC00047 MALAT-1 NCRNA00047 NEAT2 PRO1073 mascRNA HGNC:6838 microtubule associated protein 1 light chain 3 alpha MAP1LC3A ATG8E LC3 LC3A MAP1ALC3 MAP1BLC3 HGNC:6869 microtubule associated protein 7 MAP7 E-MAP-115 HGNC:6872 mitogen-activated protein kinase 10 MAPK10 JNK3 p493F12 p54bSAPK HGNC:33609 membrane associated ring-CH-type finger 11 MARCHF11 MARCH-XI RNF226 HGNC:29269 membrane associated ring-CH-type finger 4 MARCHF4 KIAA1399 MARCH-IV RNF174 HGNC:6759 myristoylated alanine rich protein kinase C substrate MARCKS 80K-L PKCSL HGNC:6901 mannan binding lectin serine peptidase 1 MASP1 MASP HGNC:6915 myoglobin MB PVALB HGNC:6922 mannose binding lectin 2 MBL2 COLEC1 HGNC:16746 muscleblind like splicing regulator 2 MBNL2 MBLL MBLL39 HGNC:18043 minichromosome maintenance 10 replication initiation factor MCM10 CNA43 DNA43 PRO2249 HGNC:6944 minichromosome maintenance complex component 2 MCM2 BM28 D3S3194 DFNA70 KIAA0030 cdc19 HGNC:19835 MAM domain containing glycosylphosphatidylinositol anchor 2 MDGA2 HGNC:6970 malate dehydrogenase 1 MDH1 HGNC:6971 malate dehydrogenase 2 MDH2 HGNC:6983 malic enzyme 1 ME1 HGNC:3498 MDS1 and EVI1 complex locus MECOM KMT8E MDS1-EVI1 PRDM3 HGNC:6998 MEFV innate immuity regulator, pyrin MEFV FMF TRIM20 HGNC:28569 meiosis specific with OB-fold MEIOB MGC35212 HGNC:7000 Meis homeobox 1 MEIS1 HGNC:28040 mex-3 RNA binding family member C MEX3C FLJ38871 RNF194 HGNC:29083 microfibril associated protein 3 like MFAP3L KIAA0626 NYD-sp9 HGNC:51291 myosin heavy chain associated RNA transcript MHRT Myheart HGNC:24008 MIA SH3 domain ER export factor 3 MIA3 FLJ39207 KIAA0268 TANGO TANGO1 UNQ6077 HGNC:33425 myocardial infarction associated transcript MIAT FLJ25967 LINC00066 NCRNA00066 Rncr2 gomafu lncRNA-MIAT HGNC:7090 MHC class I polypeptide-related sequence A MICA PERB11.1 HGNC:7097 macrophage migration inhibitory factor MIF GIF HGNC:31499 microRNA 1-1 MIR1-1 hsa-mir-1-1 HGNC:31500 microRNA 1-2 MIR1-2 hsa-mir-1-2 HGNC:31488 microRNA 101-1 MIR101-1 hsa-mir-101-1 HGNC:31489 microRNA 101-2 MIR101-2 hsa-mir-101-2 HGNC:31490 microRNA 103a-1 MIR103A1 hsa-mir-103-1 hsa-mir-103a-1 HGNC:31491 microRNA 103a-2 MIR103A2 hsa-mir-103-2 hsa-mir-103a-2 HGNC:31494 microRNA 106a MIR106A hsa-mir-106a HGNC:31501 microRNA 122 MIR122 hsa-mir-122 hsa-mir-122a miR-122 HGNC:33928 microRNA 1228 MIR1228 hsa-mir-1228 HGNC:31502 microRNA 124-1 MIR124-1 hsa-mir-124-1 hsa-mir-124a-1 HGNC:31503 microRNA 124-2 MIR124-2 hsa-mir-124-2 hsa-mir-124a-2 HGNC:31504 microRNA 124-3 MIR124-3 hsa-mir-124-3 hsa-mir-124a-3 HGNC:35319 microRNA 1254-1 MIR1254-1 hsa-mir-1254-1 HGNC:41770 microRNA 1254-2 MIR1254-2 hsa-mir-1254-2 HGNC:31505 microRNA 125a MIR125A hsa-mir-125a HGNC:31506 microRNA 125b-1 MIR125B1 hsa-mir-125b-1 HGNC:31507 microRNA 125b-2 MIR125B2 hsa-mir-125b-2 HGNC:31508 microRNA 126 MIR126 hsa-mir-126 HGNC:35284 microRNA 1291 MIR1291 hsa-mir-1291 HGNC:35301 microRNA 1303 MIR1303 hsa-mir-1303 HGNC:31514 microRNA 130a MIR130A hsa-mir-130a HGNC:31515 microRNA 130b MIR130B hsa-mir-130b HGNC:31516 microRNA 132 MIR132 hsa-mir-132 HGNC:31517 microRNA 133a-1 MIR133A1 hsa-mir-133a-1 HGNC:31518 microRNA 133a-2 MIR133A2 hsa-mir-133a-2 HGNC:31759 microRNA 133b MIR133B hsa-mir-133b HGNC:31519 microRNA 134 MIR134 hsa-mir-134 HGNC:31526 microRNA 139 MIR139 hsa-mir-139 HGNC:31529 microRNA 142 MIR142 hsa-mir-142 HGNC:31530 microRNA 143 MIR143 hsa-mir-143 HGNC:31531 microRNA 144 MIR144 hsa-mir-144 HGNC:31532 microRNA 145 MIR145 MIR-145 hsa-mir-145 HGNC:35378 microRNA 1469 MIR1469 hsa-mir-1469 HGNC:31533 microRNA 146a MIR146A hsa-mir-146 hsa-mir-146a HGNC:35379 microRNA 1470 MIR1470 hsa-mir-1470 HGNC:31761 microRNA 148b MIR148B hsa-mir-148b HGNC:31537 microRNA 150 MIR150 hsa-mir-150 HGNC:31762 microRNA 151a MIR151A hsa-mir-151 HGNC:31542 microRNA 155 MIR155 hsa-mir-155 HGNC:31543 microRNA 15a MIR15A hsa-mir-15a HGNC:31545 microRNA 16-1 MIR16-1 hsa-mir-16-1 HGNC:31546 microRNA 16-2 MIR16-2 hsa-mir-16-2 HGNC:31547 microRNA 17 MIR17 hsa-mir-17 HGNC:31590 microRNA 181a-1 MIR181A1 hsa-mir-213 HGNC:31549 microRNA 181a-2 MIR181A2 hsa-mir-181a HGNC:31554 microRNA 183 MIR183 hsa-mir-183 HGNC:31555 microRNA 184 MIR184 hsa-mir-184 HGNC:31556 microRNA 185 MIR185 hsa-mir-185 HGNC:31557 microRNA 186 MIR186 hsa-mir-186 HGNC:31548 microRNA 18a MIR18A hsa-mir-18 hsa-mir-18a HGNC:35393 microRNA 1909 MIR1909 hsa-mir-1909 HGNC:31561 microRNA 191 MIR191 hsa-mir-191 HGNC:35399 microRNA 1915 MIR1915 hsa-mir-1915 HGNC:31562 microRNA 192 MIR192 hsa-mir-192 HGNC:31564 microRNA 194-1 MIR194-1 hsa-mir-194-1 HGNC:31565 microRNA 194-2 MIR194-2 hsa-mir-194-2 HGNC:31566 microRNA 195 MIR195 hsa-mir-195 HGNC:31568 microRNA 196a-2 MIR196A2 hsa-mir-196-2 hsa-mir-196a-2 HGNC:31569 microRNA 197 MIR197 hsa-mir-197 HGNC:31571 microRNA 199a-1 MIR199A1 hsa-mir-199a-1 HGNC:31572 microRNA 199a-2 MIR199A2 hsa-mir-199a-2 HGNC:31574 microRNA 19a MIR19A hsa-mir-19a HGNC:31575 microRNA 19b-1 MIR19B1 hsa-mir-19b-1 HGNC:31576 microRNA 19b-2 MIR19B2 hsa-mir-19b-2 HGNC:31582 microRNA 204 MIR204 hsa-mir-204 HGNC:37070 microRNA 2054 MIR2054 hsa-mir-2054 HGNC:43562 MIR205 host gene MIR205HG LINC00510 HGNC:31585 microRNA 208a MIR208A hsa-mir-208 hsa-mir-208a HGNC:33669 microRNA 208b MIR208B hsa-mir-208b HGNC:31586 microRNA 21 MIR21 MIR-21 hsa-mir-21 HGNC:31587 microRNA 210 MIR210 hsa-mir-210 HGNC:31591 microRNA 214 MIR214 hsa-mir-214 HGNC:31599 microRNA 22 MIR22 hsa-mir-22 HGNC:31601 microRNA 221 MIR221 hsa-mir-221 HGNC:31603 microRNA 223 MIR223 hsa-mir-223 HGNC:31604 microRNA 224 MIR224 hsa-mir-224 HGNC:31605 microRNA 23a MIR23A hsa-mir-23a HGNC:31606 microRNA 23b MIR23B hsa-mir-23b HGNC:31607 microRNA 24-1 MIR24-1 hsa-mir-24-1 HGNC:31608 microRNA 24-2 MIR24-2 hsa-mir-24-2 HGNC:31610 microRNA 26a-1 MIR26A1 hsa-mir-26a-1 HGNC:31611 microRNA 26a-2 MIR26A2 hsa-mir-26a-2 HGNC:31612 microRNA 26b MIR26B hsa-mir-26b HGNC:31613 microRNA 27a MIR27A hsa-mir-27a HGNC:31616 microRNA 29a MIR29A hsa-mir-29 hsa-mir-29a HGNC:31619 microRNA 29b-1 MIR29B1 hsa-mir-29b-1 HGNC:31620 microRNA 29b-2 MIR29B2 hsa-mir-29b-2 HGNC:31621 microRNA 29c MIR29C hsa-mir-29c HGNC:31763 microRNA 302b MIR302B hsa-mir-302b HGNC:31624 microRNA 30a MIR30A hsa-mir-30a HGNC:31628 microRNA 30d MIR30D hsa-mir-30d HGNC:31629 microRNA 30e MIR30E hsa-mir-30e HGNC:31631 microRNA 32 MIR32 hsa-mir-32 HGNC:31632 microRNA 320a MIR320A hsa-mir-320 HGNC:35247 microRNA 320b-1 MIR320B1 hsa-mir-320b-1 HGNC:35256 microRNA 320b-2 MIR320B2 hsa-mir-320b-2 HGNC:31767 microRNA 324 MIR324 hsa-mir-324 HGNC:31770 microRNA 328 MIR328 hsa-mir-328 HGNC:31771 microRNA 330 MIR330 hsa-mir-330 HGNC:31772 microRNA 331 MIR331 hsa-mir-331 HGNC:31634 microRNA 33a MIR33A hsa-mir-33 hsa-mir-33a HGNC:32791 microRNA 33b MIR33B hsa-mir-33b HGNC:31777 microRNA 340 MIR340 hsa-mir-340 HGNC:31635 microRNA 34a MIR34A hsa-mir-34a HGNC:31867 microRNA 361 MIR361 hsa-mir-361 HGNC:38889 microRNA 3656 MIR3656 hsa-mir-3656 HGNC:31868 microRNA 375 MIR375 hsa-mir-375 HGNC:31871 microRNA 378a MIR378A hsa-mir-378 HGNC:31872 microRNA 379 MIR379 hsa-mir-379 HGNC:31873 microRNA 380 MIR380 hsa-mir-380 HGNC:31880 microRNA 423 MIR423 hsa-mir-423 HGNC:31881 microRNA 424 MIR424 hsa-mir-424 HGNC:41759 microRNA 4478 MIR4478 hsa-mir-4478 HGNC:41642 microRNA 4507 MIR4507 hsa-mir-4507 HGNC:32344 microRNA 455 MIR455 hsa-mir-455 HGNC:32340 microRNA 483 MIR483 hsa-mir-483 HGNC:32342 microRNA 486-1 MIR486-1 hsa-mir-486 HGNC:50213 microRNA 486-2 MIR486-2 hsa-mir-486-2 HGNC:32081 microRNA 492 MIR492 hsa-mir-492 HGNC:32084 microRNA 494 MIR494 hsa-mir-494 HGNC:32088 microRNA 497 MIR497 hsa-mir-497 HGNC:32133 microRNA 499a MIR499A hsa-mir-499 HGNC:32095 microRNA 519e MIR519E hsa-mir-519e HGNC:32531 microRNA 545 MIR545 hsa-mir-545 HGNC:32854 microRNA 598 MIR598 hsa-mir-598 HGNC:32861 microRNA 605 MIR605 hsa-mir-605 HGNC:32871 microRNA 615 MIR615 hsa-mir-615 HGNC:32892 microRNA 636 MIR636 hsa-mir-636 HGNC:32904 microRNA 648 MIR648 hsa-mir-648 HGNC:32916 microRNA 660 MIR660 hsa-mir-660 HGNC:35270 microRNA 663b MIR663B hsa-mir-663b HGNC:50215 microRNA 6805 MIR6805 hsa-mir-6805 HGNC:31638 microRNA 7-1 MIR7-1 hsa-mir-7-1 HGNC:33658 microRNA 744 MIR744 hsa-mir-744 HGNC:33643 microRNA 874 MIR874 hsa-mir-874 HGNC:31643 microRNA 92a-1 MIR92A1 hsa-mir-92-1 hsa-mir-92a-1 HGNC:31644 microRNA 92a-2 MIR92A2 hsa-mir-92-2 hsa-mir-92a-2 HGNC:31645 microRNA 93 MIR93 hsa-mir-93 HGNC:33682 microRNA 939 MIR939 hsa-mir-939 HGNC:33684 microRNA 941-1 MIR941-1 hsa-mir-941-1 HGNC:33685 microRNA 941-2 MIR941-2 hsa-mir-941-2 HGNC:33686 microRNA 941-3 MIR941-3 hsa-mir-941-3 HGNC:33687 microRNA 941-4 MIR941-4 hsa-mir-941-4 HGNC:50845 microRNA 941-5 MIR941-5 HGNC:31650 microRNA 99a MIR99A hsa-mir-99a HGNC:31479 microRNA let-7b MIRLET7B hsa-let-7b HGNC:31481 microRNA let-7d MIRLET7D hsa-let-7d HGNC:31485 microRNA let-7g MIRLET7G hsa-let-7g HGNC:31486 microRNA let-7i MIRLET7I hsa-let-7i HGNC:17082 modulator of VRAC current 1 MLC1 KIAA0027 LVM MLC VL HGNC:7134 MLLT1 super elongation complex subunit MLLT1 ENL LTG19 YEATS1 HGNC:7141 motilin MLN HGNC:12744 MLX interacting protein like MLXIPL CHREBP MIO MONDOB WS-bHLH bHLHd14 HGNC:7154 membrane metalloendopeptidase MME CALLA CD10 NEP HGNC:7155 matrix metallopeptidase 1 MMP1 HGNC:7159 matrix metallopeptidase 13 MMP13 CLG3 HGNC:7166 matrix metallopeptidase 2 MMP2 TBE-1 HGNC:7167 matrix metallopeptidase 20 MMP20 HGNC:14366 matrix metallopeptidase 28 MMP28 EPILYSIN MM28 MMP-25 MMP-28 HGNC:7173 matrix metallopeptidase 3 MMP3 HGNC:7175 matrix metallopeptidase 8 MMP8 HGNC:7176 matrix metallopeptidase 9 MMP9 HGNC:4979 motor neuron and pancreas homeobox 1 MNX1 HB9 HOXHB9 SCRA1 HGNC:29177 MON2 homolog, regulator of endosome-to-Golgi trafficking MON2 KIAA1040 HGNC:13937 megakaryocyte and platelet inhibitory receptor G6b MPIG6B G6b G6b-B NG31 HGNC:7218 myeloperoxidase MPO HGNC:24121 maestro MRO B29 FLJ30140 HGNC:26287 maestro heat like repeat family member 9 MROH9 ARMC11 FLJ23550 HGNC:14276 mitochondrial ribosomal protein L4 MRPL4 CGI-28 HGNC:33741 Myb/SANT DNA binding domain containing 1 MSANTD1 LOC345222 HGNC:25544 MSL complex subunit 2 MSL2 FLJ10546 KIAA1585 msl-2 HGNC:4223 myostatin MSTN HGNC:50279 mitochondrially encoded long non-coding cardiac associated RNA MT-LIPCAR LIPCAR uc022bqs.1 HGNC:7456 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 MT-ND2 NAD2 ND2 HGNC:7413 methylthioadenosine phosphorylase MTAP MSAP c86fus HGNC:7432 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 MTHFD1 HGNC:21055 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like MTHFD1L DKFZP586G1517 FLJ21145 HGNC:7436 methylenetetrahydrofolate reductase MTHFR HGNC:7454 myotubularin related protein 7 MTMR7 HGNC:7463 melatonin receptor 1A MTNR1A MEL-1A-R HGNC:7464 melatonin receptor 1B MTNR1B HGNC:15582 mucin 16, cell surface associated MUC16 CA125 FLJ14303 HGNC:23282 mucin 20, cell surface associated MUC20 FLJ14408 KIAA1359 HGNC:39755 mucin 22 MUC22 PBMUCL1 HGNC:7548 MYB proto-oncogene like 2 MYBL2 B-MYB BMYB HGNC:7551 myosin binding protein C3 MYBPC3 FHC cMyBP-C HGNC:7553 MYC proto-oncogene, bHLH transcription factor MYC MYCC bHLHe39 c-Myc HGNC:7567 myosin heavy chain 1 MYH1 MGC133384 MYHSA1 MYHa MyHC-2X/D HGNC:7568 myosin heavy chain 10 MYH10 NMMHCB HGNC:7569 myosin heavy chain 11 MYH11 SMHC SMMHC HGNC:7571 myosin heavy chain 13 MYH13 MyHC-eo HGNC:23212 myosin heavy chain 14 MYH14 FLJ13881 KIAA2034 MHC16 MYH17 HGNC:31073 myosin heavy chain 15 MYH15 KIAA1000 HGNC:7572 myosin heavy chain 2 MYH2 MYH2A MYHSA2 MYHas8 MyHC-2A MyHC-IIa HGNC:7573 myosin heavy chain 3 MYH3 HEMHC MYHC-EMB MYHSE1 SMHCE HGNC:7574 myosin heavy chain 4 MYH4 MYH2B MyHC-2B MyHC-IIb HGNC:7576 myosin heavy chain 6 MYH6 HGNC:7577 myosin heavy chain 7 MYH7 CMD1S HGNC:15906 myosin heavy chain 7B MYH7B KIAA1512 MHC14 MYH14 dJ756N5.1 HGNC:7578 myosin heavy chain 8 MYH8 MyHC-peri MyHC-pn HGNC:7579 myosin heavy chain 9 MYH9 EPSTS FTNS MHA NMHC-II-A NMMHCA HGNC:7582 myosin light chain 1 MYL1 HGNC:7583 myosin light chain 2 MYL2 CMH10 HGNC:7600 myosin IF MYO1F HGNC:1181 myelin regulatory factor MYRF MRF Ndt80 pqn-47 HGNC:7623 myelin transcription factor 1 like MYT1L KIAA1106 NZF1 ZC2H2C2 ZC2HC4B HGNC:17996 N-acetylglutamate synthase NAGS AGAS ARGA NAT7 HGNC:30092 nicotinamide phosphoribosyltransferase NAMPT PBEF HGNC:7648 neurobeachin NBEA BCL8B FLJ10197 KIAA1544 LYST2 HGNC:7673 nuclear receptor corepressor 2 NCOR2 CTG26 SMRT SMRTE TNRC14 TRAC-1 HGNC:30815 nuclear paraspeckle assembly transcript 1 NEAT1 LINC00084 MENepsilon/beta TncRNA VINC HGNC:24573 nei like DNA glycosylase 3 NEIL3 FLJ10858 FPG2 ZGRF3 hFPG2 hNEI3 HGNC:7775 nuclear factor of activated T cells 1 NFATC1 NF-ATC NFAT2 NFATc HGNC:25906 nuclear factor of activated T cells 2 interacting protein NFATC2IP ESC2 FLJ14639 NIP45 RAD60 HGNC:7794 nuclear factor kappa B subunit 1 NFKB1 KBF1 NF-kB1 NF-kappaB NFKB-p50 NFkappaB p105 p50 HGNC:7800 NFKB inhibitor like 1 NFKBIL1 IKBL HGNC:21584 NFKB activating protein like NKAPL bA424I5.1 HGNC:32940 NK2 homeobox 6 NKX2-6 CSX2 NKX4-2 HGNC:16400 NLR family pyrin domain containing 3 NLRP3 AGTAVPRL AII AVP CLR1.1 FCAS FCU MWS NALP3 PYPAF1 HGNC:16789 nicotinamide nucleotide adenylyltransferase 2 NMNAT2 KIAA0479 PNAT2 HGNC:7858 N-myristoyltransferase 2 NMT2 HGNC:7873 nitric oxide synthase 2 NOS2 HEP-NOS NOS iNOS HGNC:7876 nitric oxide synthase 3 NOS3 ECNOS eNOS HGNC:7881 notch receptor 1 NOTCH1 HGNC:19311 neuronal PAS domain protein 3 NPAS3 MOP6 PASD6 bHLHe12 HGNC:7939 natriuretic peptide A NPPA HGNC:7940 natriuretic peptide B NPPB HGNC:7941 natriuretic peptide C NPPC CNP HGNC:7943 natriuretic peptide receptor 1 NPR1 ANPa GUCY2A HGNC:7955 neuropeptide Y NPY PYY4 HGNC:7984 nuclear receptor subfamily 5 group A member 2 NR5A2 B1F2 FTZ-F1 FTZ-F1beta LRH-1 LRH1 hB1F hB1F-2 HGNC:7995 nardilysin convertase NRDC hNRD1 hNRD2 HGNC:7997 neuregulin 1 NRG1 GGF HRG NDF HGNC:14288 netrin G2 NTNG2 KIAA1857 Lmnt2 HGNC:8040 neurotensin receptor 2 NTSR2 NTR2 HGNC:8044 nucleobindin 2 NUCB2 NEFA HGNC:8048 nudix hydrolase 1 NUDT1 HGNC:18017 nucleoporin 160 NUP160 FLJ22583 KIAA0197 HGNC:44164 nuclear protein 2, transcriptional regulator NUPR2 HGNC:8105 oncomodulin OCM OCM1 HGNC:8114 outer dense fiber of sperm tails 2 ODF2 CT134 ODF84 HGNC:21017 orofacial cleft 1 candidate 1 OFCC1 MRDS1 Opo HGNC:7056 O-GlcNAcase OGA MEA5 NCOAT HGNC:8126 osteoglycin OGN OIF SLRR3A mimecan HGNC:9398 oligodendrocyte transcription factor 2 OLIG2 OLIGO2 RACK17 bHLHe19 HGNC:8133 oxidized low density lipoprotein receptor 1 OLR1 CLEC8A LOX-1 SCARE1 HGNC:8139 one cut homeobox 2 ONECUT2 OC-2 HGNC:13399 one cut homeobox 3 ONECUT3 HGNC:8142 outer mitochondrial membrane lipid metabolism regulator OPA3 OPA3 FLJ22187 MGA3 HGNC:14999 olfactory receptor family 13 subfamily G member 1 OR13G1 HGNC:13971 olfactory receptor family 14 subfamily J member 1 OR14J1 hs6M1-28 HGNC:8498 orosomucoid 1 ORM1 HGNC:16392 oxysterol binding protein like 5 OSBPL5 KIAA1534 OBPH1 ORP5 HGNC:29961 osteocrin OSTN HGNC:19656 otopetrin 1 OTOP1 HGNC:15804 ovo like zinc finger 2 OVOL2 CHED HOVO2 bA504H3.3 HGNC:8537 purinergic receptor P2X 7 P2RX7 MGC20089 P2X7 HGNC:8540 purinergic receptor P2Y11 P2RY11 P2Y11 HGNC:18124 purinergic receptor P2Y12 P2RY12 HORK3 P2Y12 SP1999 HGNC:8541 purinergic receptor P2Y2 P2RY2 P2U HGNC:17068 palladin, cytoskeletal associated protein PALLD CGI-151 KIAA0992 SIH002 HGNC:8602 pappalysin 1 PAPPA ASBABP2 DIPLA1 IGFBP-4ase PAPA PAPP-A PAPPA1 HGNC:14654 parvin gamma PARVG HGNC:49593 prostate cancer associated transcript 19 PCAT19 LINC01190 HGNC:8744 proprotein convertase subtilisin/kexin type 2 PCSK2 PC2 SPC2 HGNC:20001 proprotein convertase subtilisin/kexin type 9 PCSK9 FH3 NARC-1 HGNC:8760 programmed cell death 1 PDCD1 CD279 PD-1 PD1 hSLE1 HGNC:8777 phosphodiesterase 2A PDE2A HGNC:8783 phosphodiesterase 4D PDE4D HGNC:15580 phosphodiesterase 4D interacting protein PDE4DIP KIAA0454 KIAA0477 MMGL HGNC:8794 phosphodiesterase 8B PDE8B HGNC:8799 platelet derived growth factor subunit A PDGFA PDGF-A PDGF1 HGNC:30620 platelet derived growth factor D PDGFD IEGF MSTP036 SCDGF-B HGNC:6107 pancreatic and duodenal homeobox 1 PDX1 IDX-1 MODY4 PDX-1 STF-1 HGNC:18486 PDZ domain containing 2 PDZD2 KIAA0300 HGNC:33631 platelet endothelial aggregation receptor 1 PEAR1 FLJ00193 JEDI HGNC:8823 platelet and endothelial cell adhesion molecule 1 PECAM1 CD31 HGNC:8831 proenkephalin PENK HGNC:8846 period circadian regulator 2 PER2 KIAA0347 HGNC:8861 platelet factor 4 PF4 CXCL4 SCYB4 HGNC:8881 profilin 1 PFN1 HGNC:21731 phosphoglycerate mutase family member 4 PGAM4 PGAM-B PGAM1 PGAM3 dJ1000K24.1 HGNC:8893 placental growth factor PGF D12S1900 PIGF PLGF PlGF-2 SHGC-10760 HGNC:8904 peptidoglycan recognition protein 1 PGLYRP1 PGRP PGRP-S PGRPS TAG7 HGNC:30013 peptidoglycan recognition protein 2 PGLYRP2 PGLYRPL PGRP-L PGRPL TAGL-like tagL tagL-alpha tagl-beta HGNC:20990 phosphatase and actin regulator 1 PHACTR1 KIAA1733 dJ257A7.2 HGNC:20956 phosphatase and actin regulator 2 PHACTR2 KIAA0680 HGNC:10241 phosphorylated adaptor for RNA export PHAX FLJ13193 HGNC:26509 PH domain containing endocytic trafficking adaptor 1 PHETA1 FLJ32356 IPIP27A SES1 HGNC:27161 PH domain containing endocytic trafficking adaptor 2 PHETA2 DKFZp686J07229 IPIP27B SES2 HGNC:20672 PHD finger protein 8 PHF8 JHDM1F KDM7B KIAA1111 ZNF422 HGNC:8966 phosphatidylinositol glycan anchor biosynthesis class L PIGL HGNC:8971 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2A PI3K-C2alpha HGNC:8973 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C2G HGNC:21043 PITPNM family member 3 PITPNM3 ACKR6 NIR1 RDGBA3 HGNC:9017 cAMP-dependent protein kinase inhibitor alpha PKIA HGNC:17999 protein kinase N3 PKN3 PKNbeta UTDP4-1 HGNC:9030 phospholipase A2 group IB PLA2G1B HGNC:9031 phospholipase A2 group IIA PLA2G2A HGNC:9035 phospholipase A2 group IVA PLA2G4A cPLA2-alpha HGNC:9040 phospholipase A2 group VII PLA2G7 LDL-PLA2 PAFAH HGNC:9051 plasminogen activator, tissue type PLAT HGNC:9052 plasminogen activator, urokinase PLAU UPA URK HGNC:9053 plasminogen activator, urokinase receptor PLAUR CD87 UPAR URKR HGNC:26215 phospholipase B domain containing 1 PLBD1 FLJ22662 HGNC:9060 phospholipase C delta 1 PLCD1 HGNC:9064 phospholipase C like 2 PLCL2 KIAA1092 HGNC:19218 phospholipase C zeta 1 PLCZ1 NYD-SP27 PLCzeta HGNC:26879 phospholipase D family member 5 PLD5 FLJ40773 HGNC:18211 pleckstrin homology domain containing J1 PLEKHJ1 FLJ10297 HGNC:9071 plasminogen PLG HGNC:248 perilipin 2 PLIN2 ADRP HGNC:9201 proopiomelanocortin POMC ACTH CLIP LPH MSH NPP POC HGNC:9204 paraoxonase 1 PON1 ESA HGNC:9205 paraoxonase 2 PON2 HGNC:16953 periostin POSTN OSF-2 PN periostin HGNC:9210 POU class 1 homeobox 1 POU1F1 GHF-1 PIT-1 POU1F1a HGNC:9215 POU class 3 homeobox 2 POU3F2 44841 BRN2 POUF3 HGNC:9232 peroxisome proliferator activated receptor alpha PPARA NR1C1 hPPAR HGNC:9236 peroxisome proliferator activated receptor gamma PPARG NR1C3 PPARG1 PPARG2 PPARgamma HGNC:9237 PPARG coactivator 1 alpha PPARGC1A PGC-1alpha PGC1 PGC1A HGNC:9240 pro-platelet basic protein PPBP Beta-TG CTAP3 CTAPIII CXCL7 LA-PF4 LDGF MDGF NAP-2 NAP-2-L1 PBP SCYB7 TGB TGB1 b-TG1 HGNC:9253 peptidylprolyl isomerase A PPIA CYPA HGNC:9284 protein phosphatase 1 regulatory subunit 10 PPP1R10 CAT53 FB19 PNUTS p99 HGNC:9294 protein phosphatase 1 regulatory subunit 3D PPP1R3D HGNC:23732 protein phosphatase 2 regulatory subunit Bdelta PPP2R2D B55D B55delta MDS026 HGNC:9311 protein phosphatase 2 regulatory subunit B'gamma PPP2R5C B56G B56gamma PR61G HGNC:13995 PR/SET domain 10 PRDM10 KIAA1231 MGC131802 PFM7 HGNC:13998 PR/SET domain 13 PRDM13 PFM10 HGNC:20340 prickle planar cell polarity protein 2 PRICKLE2 DKFZp686D143 HGNC:9445 prolactin PRL HGNC:5186 protein arginine methyltransferase 2 PRMT2 MGC111373 HGNC:10894 protein arginine methyltransferase 5 PRMT5 SKB1Hs HGNC:5188 protein arginine methyltransferase 8 PRMT8 HGNC:9451 protein C, inactivator of coagulation factors Va and VIIIa PROC HGNC:9452 protein C receptor PROCR CCD41 CD201 EPCR HGNC:19958 protein only RNase P catalytic subunit PRORP MRPP3 HGNC:9456 protein S PROS1 HGNC:9460 protein Z, vitamin K dependent plasma glycoprotein PROZ PZ HGNC:9495 proteinase 3 PRTN3 ACPA AGP7 C-ANCA MBT P29 PR-3 HGNC:9535 proteasome 20S subunit alpha 6 PSMA6 IOTA MGC22756 MGC2333 MGC23846 PROS27 p27K HGNC:24472 proline and serine rich coiled-coil 1 PSRC1 DDA3 HGNC:9588 phosphatase and tensin homolog PTEN MMAC1 PTEN1 TEP1 HGNC:9594 prostaglandin E receptor 2 PTGER2 EP2 HGNC:9603 prostaglandin I2 synthase PTGIS CYP8A1 PGIS HGNC:9604 prostaglandin-endoperoxide synthase 1 PTGS1 COX1 PGHS-1 PTGHS HGNC:9605 prostaglandin-endoperoxide synthase 2 PTGS2 COX2 HGNC:9606 parathyroid hormone PTH PTH1 HGNC:9665 protein tyrosine phosphatase receptor type B PTPRB HGNC:9677 protein tyrosine phosphatase receptor type N2 PTPRN2 IA-2beta ICAAR KIAA0387 phogrin HGNC:9692 pentraxin 3 PTX3 TSG-14 HGNC:9723 glycogen phosphorylase B PYGB HGNC:9748 peptide YY PYY PYY1 HGNC:9750 PZP alpha-2-macroglobulin like PZP CPAMD6 HGNC:9756 quiescin sulfhydryl oxidase 1 QSOX1 HGNC:16524 RAB14, member RAS oncogene family RAB14 FBP RAB-14 HGNC:9758 RAB1A, member RAS oncogene family RAB1A YPT1 HGNC:18260 RAB20, member RAS oncogene family RAB20 FLJ20429 HGNC:9768 RAB28, member RAS oncogene family RAB28 HGNC:9779 RAB3D, member RAS oncogene family RAB3D D2-2 RAB16 RAD3D HGNC:24817 rabaptin, RAB GTPase binding effector protein 2 RABEP2 FLJ23282 FRA HGNC:4399 receptor for activated C kinase 1 RACK1 Gnb2-rs1 H12.3 HGNC:9842 ral guanine nucleotide dissociation stimulator RALGDS RGDS RGF RalGEF HGNC:9868 retinoic acid receptor responder 2 RARRES2 HP10433 TIG2 HGNC:9875 Ras protein specific guanine nucleotide releasing factor 1 RASGRF1 CDC25 CDC25L GNRP GRF55 H-GRF55 PP13187 HGNC:9889 RB binding protein 6, ubiquitin ligase RBBP6 P2P-R PACT SNAMA HGNC:9922 retinol binding protein 4 RBP4 HGNC:14423 retinol dehydrogenase 8 RDH8 PRRDH SDR28C2 HGNC:9958 renin REN HGNC:9967 ret proto-oncogene RET CDHF12 CDHR16 PTC RET51 HGNC:20389 resistin RETN ADSF FIZZ3 RETN1 HGNC:21478 regulatory factor X6 RFX6 MGC33442 dJ955L16.1 HGNC:18738 Rho related BTB domain containing 1 RHOBTB1 KIAA0740 HGNC:18756 Rho related BTB domain containing 2 RHOBTB2 DBC2 KIAA0717 HGNC:10021 receptor interacting serine/threonine kinase 3 RIPK3 RIP3 HGNC:10027 relaxin 2 RLN2 H2 RLXH2 bA12D24.1.1 bA12D24.1.2 HGNC:14539 ring finger protein 213 RNF213 ALO17 KIAA1554 NET57 HGNC:18505 ring finger protein 43 RNF43 DKFZp781H0392 FLJ20315 URCC HGNC:10073 RNA guanylyltransferase and 5'-phosphatase RNGTT HCE HCE1 hCAP HGNC:10227 RNA, U6 small nuclear 1 RNU6-1 U6 U6-1 HGNC:16185 reactive oxygen species modulator 1 ROMO1 MTGMP bA353C18.2 HGNC:10261 ROS proto-oncogene 1, receptor tyrosine kinase ROS1 MCF3 ROS c-ros-1 HGNC:10334 ribosomal protein L31 RPL31 L31 HGNC:32422 reprimo like RPRML MGC43894 HGNC:24883 relaxin family peptide receptor 3 RXFP3 GPCR135 RXFPR3 SALPR HGNC:10484 ryanodine receptor 2 RYR2 ARVC2 VTSIP HGNC:10486 S100 calcium binding protein A1 S100A1 S100-alpha HGNC:10489 S100 calcium binding protein A12 S100A12 CAAF1 CAGC CGRP ENRAGE MRP6 p6 HGNC:10494 S100 calcium binding protein A4 S100A4 18A2 42A FSP1 P9KA PEL98 HGNC:10498 S100 calcium binding protein A8 S100A8 60B8AG CGLA MRP8 P8 HGNC:10499 S100 calcium binding protein A9 S100A9 60B8AG CGLB LIAG MAC387 MIF MRP14 NIF P14 HGNC:10504 S100 calcium binding protein P S100P HGNC:10513 serum amyloid A1 SAA1 PIG4 TP53I4 HGNC:10527 spalt like transcription factor 3 SALL3 ZNF796 HGNC:10528 SAM domain, SH3 domain and nuclear localization signals 1 SAMSN1 HACS1 NASH1 SASH2 SH3D6B SLy2 HGNC:19000 scavenger receptor class A member 3 SCARA3 APC7 CSR CSR1 MSLR1 MSRL1 HGNC:1664 scavenger receptor class B member 1 SCARB1 CLA-1 CLA1 SR-BI SRB1 HGNC:26406 sodium channel and clathrin linker 1 SCLT1 FLJ30655 hCAP-1A HGNC:10582 sodium voltage-gated channel alpha subunit 10 SCN10A Nav1.8 PN3 SNS hPN3 HGNC:10593 sodium voltage-gated channel alpha subunit 5 SCN5A CDCD2 CMPD2 HB1 HB2 HBBD HH1 ICCD IVF LQT3 Nav1.5 PFHB1 SSS1 HGNC:13441 signal peptide, CUB domain and EGF like domain containing 1 SCUBE1 LQT3 HGNC:10658 syndecan 1 SDC1 HB1 SYND1 syndecan HGNC:10661 syndecan 4 SDC4 HBBD amphiglycan ryudocan HGNC:40047 SEC14 like lipid binding 6 SEC14L6 PFHB1 HGNC:10718 selectin E SELE CD62E IVF HGNC:10751 selenoprotein P SELENOP HB2 SELP SEPP HGNC:10721 selectin P SELP CD62P GMP140 HH1 PADGEM PSEL HGNC:10722 selectin P ligand SELPLG CD162 SSS1 HGNC:10726 semaphorin 3D SEMA3D CDCD2 Sema-Z2 HGNC:10728 semaphorin 3F SEMA3F CMPD2 Sema4 HGNC:8941 serpin family A member 1 SERPINA1 A1A A1AT ICCD PI1 alpha-1-antitrypsin alpha1AT HGNC:18359 serpin family A member 12 SERPINA12 OL-64 Vaspin HGNC:16 serpin family A member 3 SERPINA3 ACT HGNC:8723 serpin family A member 5 SERPINA5 PAI3 PROCI HGNC:8584 serpin family B member 2 SERPINB2 HsT1201 HGNC:775 serpin family C member 1 SERPINC1 ATIII MGC22579 HGNC:4838 serpin family D member 1 SERPIND1 D22S673 HC-II HC2 HLS2 HGNC:8583 serpin family E member 1 SERPINE1 PAI HGNC:9075 serpin family F member 2 SERPINF2 A2AP AAP ALPHA-2-PI API HGNC:15955 seizure related 6 homolog SEZ6 HGNC:10766 splicing factor 3a subunit 2 SF3A2 PRPF11 Prp11 SAP62 SF3a66 HGNC:10776 secreted frizzled related protein 1 SFRP1 FRP FRP-1 SARP2 HGNC:10778 secreted frizzled related protein 4 SFRP4 FRP-4 FRZB-2 frpHE HGNC:10779 secreted frizzled related protein 5 SFRP5 SARP3 HGNC:10810 serum/glucocorticoid regulated kinase 1 SGK1 HGNC:15474 SH3 and multiple ankyrin repeat domains 1 SHANK1 SPANK-1 SSTRIP synamon HGNC:29869 SHC adaptor protein 2 SHC2 SCK SHCB SLI HGNC:25116 Src homology 2 domain containing F SHF HGNC:10883 SIM bHLH transcription factor 2 SIM2 MGC119447 bHLHe15 HGNC:14929 sirtuin 1 SIRT1 SIR2L1 HGNC:10886 sirtuin 2 SIRT2 HGNC:14931 sirtuin 3 SIRT3 SIR2L3 HGNC:14933 sirtuin 5 SIRT5 HGNC:14934 sirtuin 6 SIRT6 HGNC:23089 solute carrier family 13 member 5 SLC13A5 INDY NACT HGNC:49445 SLC16A1 antisense RNA 1 SLC16A1-AS1 ENST00000421157.1 HGNC:10964 solute carrier family 22 member 18 SLC22A18 BWR1A ITM TSSC5 HGNC:10967 solute carrier family 22 member 3 SLC22A3 44837 EMT HGNC:27091 solute carrier family 22 member 31 SLC22A31 HGNC:10970 solute carrier family 22 member 6 SLC22A6 OAT1 PAHT ROAT1 HGNC:11013 solute carrier family 30 member 2 SLC30A2 HGNC:14463 solute carrier family 39 member 11 SLC39A11 HGNC:30225 solute carrier family 52 member 1 SLC52A1 FLJ10060 GPCR42 PAR2 RFVT1 hRFT1 HGNC:11042 solute carrier family 6 member 1 SLC6A1 GABATHG GABATR GAT1 HGNC:26441 solute carrier family 6 member 18 SLC6A18 FLJ31236 Xtrp2 HGNC:11050 solute carrier family 6 member 4 SLC6A4 5-HTT SERT1 HGNC:13819 solute carrier organic anion transporter family member 1C1 SLCO1C1 OATP-F OATP1 OATP1C1 HGNC:11089 sarcolipin SLN MGC12301 MGC125854 MGC125855 HGNC:6773 SMAD family member 7 SMAD7 HGNC:11100 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 SMARCA4 BAF190 BRG1 FLJ39786 SNF2 SNF2-BETA SNF2LB SWI2 hSNF2b HGNC:27321 small integral membrane protein 14 SMIM14 FLJ13289 HGNC:20323 SPARC related modular calcium binding 2 SMOC2 SMAP2 HGNC:33098 small nucleolar RNA host gene 8 SNHG8 LINC00060 NCRNA00060 HGNC:14970 sorting nexin 6 SNX6 HGNC:14971 sorting nexin 7 SNX7 HGNC:19391 suppressor of cytokine signaling 3 SOCS3 CIS3 Cish3 SOCS-3 SSI-3 HGNC:11179 superoxide dismutase 1 SOD1 IPOA HGNC:11180 superoxide dismutase 2 SOD2 GClnc1 HGNC:11181 superoxide dismutase 3 SOD3 EC-SOD HGNC:16699 sortilin related VPS10 domain containing receptor 3 SORCS3 KIAA1059 SORCS HGNC:18122 SRY-box transcription factor 17 SOX17 HGNC:11194 SRY-box transcription factor 18 SOX18 HGNC:11195 SRY-box transcription factor 2 SOX2 HGNC:11197 SRY-box transcription factor 21 SOX21 SOX25 HGNC:28393 spermatogenesis associated 2 like SPATA2L MGC26885 tamo HGNC:38601 SPATA31 subfamily D member 4 SPATA31D4 FLJ43859 HGNC:11255 secreted phosphoprotein 1 SPP1 BSPI ETA-1 HGNC:24045 serine palmitoyltransferase small subunit B SPTSSB ADMP ssSPTb HGNC:11290 sterol regulatory element binding transcription factor 2 SREBF2 SREBP2 bHLHd2 HGNC:29580 serine rich single-pass membrane protein 1 SSMEM1 FLJ40316 HGNC:19342 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST6GALNAC5 MGC3184 ST6GalNAcV HGNC:18628 stabilin 1 STAB1 CLEVER-1 FEEL-1 FELE-1 FEX1 KIAA0246 SCARH2 STAB-1 HGNC:19161 StAR related lipid transfer domain containing 8 STARD8 ARHGAP38 KIAA0189 HGNC:11373 stanniocalcin 1 STC1 HGNC:18539 syntaxin 1B STX1B HGNC:11445 syntaxin binding protein 2 STXBP2 Hunc18b UNC18B HGNC:11459 sulfotransferase family 2B member 1 SULT2B1 HSST2 HGNC:18587 Sad1 and UNC84 domain containing 1 SUN1 FLJ12407 KIAA0810 HGNC:32421 SUZ12 pseudogene 1 SUZ12P1 HGNC:15985 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 SVEP1 FLJ13529 POLYDOM bA427L11.3 HGNC:15587 synaptotagmin like 3 SYTL3 SLP3 exophilin-6 HGNC:11517 tachykinin precursor 1 TAC1 NPK HGNC:11534 TATA-box binding protein associated factor, RNA polymerase I subunit C TAF1C MGC:39976 SL1 TAFI110 TAFI95 HGNC:18882 taste 2 receptor member 50 TAS2R50 T2R51 HGNC:11587 transducin beta like 3 TBL3 SAZD UTP13 HGNC:11595 T-box transcription factor 18 TBX18 HGNC:11604 T-box transcription factor 5 TBX5 HGNC:11609 thromboxane A synthase 1 TBXAS1 CYP5 CYP5A1 THAS TS TXAS TXS HGNC:11616 transcription elongation factor A like 1 TCEAL1 SIIR WEX9 p21 pp21 HGNC:11632 transcription factor 21 TCF21 POD1 bHLHa23 HGNC:29943 teneurin transmembrane protein 2 TENM2 KIAA1127 TEN2 Ten-M2 HGNC:11760 tissue factor pathway inhibitor TFPI EPI TFI TFPI1 HGNC:11766 transforming growth factor beta 1 TGFB1 CED TGFbeta HGNC:11768 transforming growth factor beta 2 TGFB2 HGNC:11772 transforming growth factor beta receptor 1 TGFBR1 ACVRLK4 ALK-5 ALK5 TBR-i TBRI HGNC:11784 thrombomodulin THBD BDCA-3 CD141 THRM HGNC:11785 thrombospondin 1 THBS1 THBS THBS-1 TSP TSP-1 TSP1 HGNC:11786 thrombospondin 2 THBS2 TSP2 HGNC:11788 thrombospondin 4 THBS4 HGNC:11795 thrombopoietin THPO MPLLG TPO HGNC:11804 TIA1 cytotoxic granule associated RNA binding protein like 1 TIAL1 TIAR HGNC:11820 TIMP metallopeptidase inhibitor 1 TIMP1 EPO HGNC:11821 TIMP metallopeptidase inhibitor 2 TIMP2 CSC-21K HGNC:11822 TIMP metallopeptidase inhibitor 3 TIMP3 HGNC:11823 TIMP metallopeptidase inhibitor 4 TIMP4 HGNC:11847 toll like receptor 1 TLR1 CD281 KIAA0012 rsc786 HGNC:11848 toll like receptor 2 TLR2 CD282 TIL4 HGNC:11850 toll like receptor 4 TLR4 ARMD10 CD284 TLR-4 hToll HGNC:16998 transmembrane p24 trafficking protein 10 TMED10 P24(DELTA) TMP21 p23 p24d1 p24delta1 HGNC:31009 transmembrane protein 250 TMEM250 bA83N9.1 HGNC:25913 transmembrane protein 87B TMEM87B FLJ14681 HGNC:11881 thymosin beta 4 X-linked TMSB4X TB4X HGNC:5318 tenascin C TNC MGC167029 TN HGNC:11892 tumor necrosis factor TNF DIF TNF-alpha TNFSF2 HGNC:11905 TNF receptor superfamily member 10b TNFRSF10B CD262 DR5 KILLER TRAIL-R2 TRAILR2 TRICK2A TRICKB HGNC:11909 TNF receptor superfamily member 11b TNFRSF11B OCIF TR1 HGNC:26966 TNFRSF14 antisense RNA 1 TNFRSF14-AS1 ENST00000416860.2 HGNC:11916 TNF receptor superfamily member 1A TNFRSF1A CD120a TNF-R TNF-R-I TNF-R55 TNFAR TNFR60 HGNC:11917 TNF receptor superfamily member 1B TNFRSF1B CD120b TNF-R-II TNF-R75 TNFBR TNFR80 p75 HGNC:11925 TNF superfamily member 10 TNFSF10 Apo-2L CD253 TL2 TRAIL HGNC:11926 TNF superfamily member 11 TNFSF11 CD254 ODF OPGL RANKL TRANCE HGNC:11927 TNF superfamily member 12 TNFSF12 APO3L DR3LG TWEAK HGNC:11929 TNF superfamily member 13b TNFSF13B BAFF BLYS CD257 TALL-1 TALL1 THANK HGNC:11934 TNF superfamily member 4 TNFSF4 CD252 OX-40L gp34 HGNC:17757 tenomodulin TNMD BRICD4 ChM1L TEM myodulin tendin HGNC:11947 troponin I3, cardiac type TNNI3 CMH7 TNNC1 HGNC:11949 troponin T2, cardiac type TNNT2 CMPD2 HGNC:11976 tenascin XB TNXB TNXBS XB XBS HGNC:33715 TOG array regulator of axonemal microtubules 2 TOGARAM2 Crescerin-2 FLJ43249 LOC165186 HGNC:11998 tumor protein p53 TP53 LFS1 p53 HGNC:12015 thyroid peroxidase TPO TPX HGNC:1343 TRAF3 interacting protein 2 TRAF3IP2 ACT1 CIKS DKFZP586G0522 HGNC:29011 tetratricopeptide repeat and ankyrin repeat containing 1 TRANK1 KIAA0342 LBA1 HGNC:12168 T cell receptor beta joining 2-1 TRBJ2-1 TCRBJ2S1 TRBJ21 HGNC:12185 T cell receptor beta variable 12-3 TRBV12-3 TCRBV12S3 TCRBV8S1 TRBV123 HGNC:12195 T cell receptor beta variable 2 TRBV2 TCRBV22S1A2N1T TCRBV2S1 HGNC:12210 T cell receptor beta variable 29-1 TRBV29-1 TCRBV29S1 TCRBV4S1A1T TRBV291 HGNC:12214 T cell receptor beta variable 30 TRBV30 TCRBV20S1A1N2 TCRBV30S1 HGNC:12266 trehalase TREH MGC129621 TRE TREA HGNC:17760 triggering receptor expressed on myeloid cells 1 TREM1 CD354 TREM-1 HGNC:20434 triggering receptor expressed on myeloid cells like 1 TREML1 TLT1 dJ238O23.3 HGNC:16384 tripartite motif containing 28 TRIM28 KAP1 PPP1R157 RNF96 TF1B TIF1B HGNC:16289 tripartite motif containing 31 TRIM31 C6orf13 HCG1 HCGI RNF HGNC:32671 tripartite motif containing 72 TRIM72 MG53 HGNC:17009 TRIO and F-actin binding protein TRIOBP HRIHFB2122 KIAA1662 TAP68 Tara HGNC:12336 transient receptor potential cation channel subfamily C member 4 TRPC4 HTRP4 TRP4 HGNC:18082 transient receptor potential cation channel subfamily V member 2 TRPV2 VRL VRL-1 VRL1 HGNC:14006 transient receptor potential cation channel subfamily V member 6 TRPV6 CaT1 HGNC:19750 tetratricopeptide repeat domain 7A TTC7A KIAA1140 HGNC:28432 tetratricopeptide repeat domain 9C TTC9C MGC29649 HGNC:12403 titin TTN CMH9 CMPD4 FLJ32040 LGMD2J MYLK5 TMD HGNC:26066 taurine up-regulated 1 TUG1 FLJ20618 LINC00080 NCRNA00080 HGNC:12428 twist family bHLH transcription factor 1 TWIST1 BPES2 CRS1 H-twist SCS bHLHa38 HGNC:12435 thioredoxin TXN TRX HGNC:16952 thioredoxin interacting protein TXNIP ARRDC6 EST01027 HHCPA78 THIF VDUP1 HGNC:18155 thioredoxin reductase 2 TXNRD2 SELZ TR TR3 TRXR2 HGNC:25847 ubiquitin conjugating enzyme E2 Z UBE2Z FLJ13855 USE1 HGNC:12507 upstream binding protein 1 UBP1 LBP-1a HGNC:37126 urothelial cancer associated 1 UCA1 CUDR LINC00178 UCAT1 onco-lncRNA-36 HGNC:12513 ubiquitin C-terminal hydrolase L1 UCHL1 PGP9.5 Uch-L1 HGNC:12516 urocortin UCN UI UROC HGNC:12518 uncoupling protein 2 UCP2 SLC25A8 HGNC:15664 UDP-glucose glycoprotein glucosyltransferase 2 UGGT2 FLJ10873 FLJ11485 HUGT2 MGC117360 MGC150689 MGC87276 HGNC:18563 ubiquitin specific peptidase 29 USP29 HGNC:20063 ubiquitin specific peptidase 37 USP37 KIAA1594 HGNC:12636 urotensin 2 UTS2 PRO1068 U-II UCN2 UII HGNC:12647 vesicle associated membrane protein 8 VAMP8 EDB HGNC:12661 ventral anterior homeobox 2 VAX2 DRES93 HGNC:12663 vascular cell adhesion molecule 1 VCAM1 CD106 HGNC:12669 voltage dependent anion channel 1 VDAC1 MGC111064 PORIN HGNC:12679 vitamin D receptor VDR NR1I1 PPP1R163 HGNC:12680 vascular endothelial growth factor A VEGFA VEGF-A VPF HGNC:12681 vascular endothelial growth factor B VEGFB VEGFL HGNC:12693 vasoactive intestinal peptide VIP HGNC:23663 vitamin K epoxide reductase complex subunit 1 VKORC1 HGNC:12724 vitronectin VTN VN HGNC:24709 von Willebrand factor A domain containing 2 VWA2 AMACO CCSP-2 FLJ16213 FLJ45857 NET42 HGNC:30200 von Willebrand factor C domain containing 2 VWC2 PSST739 UNQ739 HGNC:12726 von Willebrand factor VWF HGNC:25706 WD repeat domain 59 WDR59 FLJ12270 HGNC:12774 Wnt family member 1 WNT1 HGNC:12786 Wnt family member 7A WNT7A Wnt-7a HGNC:12796 WT1 transcription factor WT1 AWT1 NPHS4 WAGR WIT-2 HGNC:12805 xanthine dehydrogenase XDH XO XOR HGNC:19066 zinc finger and BTB domain containing 12 ZBTB12 D6S59E G10 NG35 HGNC:30869 zinc finger CCCH-type containing 7B ZC3H7B DKFZp434K0920 FLJ13787 KIAA1031 RoXaN HGNC:29313 zinc finger DBF-type containing 2 ZDBF2 FLJ45338 KIAA1571 HGNC:33101 ZNFX1 antisense RNA 1 ZFAS1 HSUP1 HSUP2 HGNC:777 zinc finger homeobox 3 ZFHX3 FLJ26184 ZNF927 HGNC:30939 zinc finger homeobox 4 ZFHX4 FLJ20980 ZFH4 HGNC:12872 Zic family member 1 ZIC1 ZIC ZNF201 HGNC:20393 Zic family member 4 ZIC4 HGNC:20322 Zic family member 5 ZIC5 HGNC:12939 zinc finger protein 154 ZNF154 pHZ-92 HGNC:12994 zinc finger protein 202 ZNF202 ZKSCAN10 ZSCAN42 HGNC:13070 zinc finger protein 277 ZNF277 NRIF4 HGNC:13847 zinc finger protein 311 ZNF311 HGNC:23305 zinc finger protein 480 ZNF480 MGC32104 HGNC:23525 ZNF503 antisense RNA 2 ZNF503-AS2 HGNC:29380 zinc finger protein 512 ZNF512 KIAA1805 HGNC:29009 zinc finger protein 518A ZNF518A KIAA0335 HGNC:29384 zinc finger protein 528 ZNF528 KIAA1827 HGNC:29025 zinc finger protein 536 ZNF536 KIAA0390 HGNC:26421 zinc finger protein 582 ZNF582 FLJ30927 HGNC:25213 ZNF582 divergent transcript ZNF582-DT HGNC:30570 zinc finger protein 627 ZNF627 FLJ90365 HGNC:28857 zinc finger protein 682 ZNF682 BC39498_3 HGNC:32034 zinc finger protein 697 ZNF697 MGC45731 HGNC:32470 zinc finger protein 730 ZNF730 HGNC:21711 zinc finger protein 804A ZNF804A HGNC:13051 ZPR1 zinc finger ZPR1 HGNC:30990 zinc finger SWIM-type containing 2 ZSWIM2 MEX MGC33890 ZZZ2 NC_000001.11:g.193213064_19325694del NC_000003.12:g.45217649_45221633del NC_000016.10:g.82706957_82712663dul NC_000001.11:g.232154677_232164229dul LPA KIV-2 NC_000001.11:g.95164205_95170962dul NC_000012.12:g.18574942_18579403dul NC_000010.11:g.43623658_43625593dul Chr11_CpG hypermethylation cg05575921 hypomethylation Chr20_CpG hypermethylation cg06500161 hypermethylation cg00058449 hypomethylation cg00459243 hypomethylation cg00805874 hypomethylation cg04603811 hypomethylation cg06636203 hypomethylation cg08975528 hypomethylation cg09788778 hypomethylation cg10917426 hypomethylation cg11645762 hypomethylation cg13127825 hypomethylation cg14562426 hypomethylation cg14734916 hypomethylation cg16463880 hypomethylation cg17243044 hypomethylation cg25013586 hypomethylation cg25110523 hypomethylation cg25470384 hypomethylation cg25861453 hypomethylation CHR6_CpG_1 hypomethylation CHR6_CpG_2 hypomethylation CHR6_CpG_23.24 hypomethylation CHR6_CpG_28 hypomethylation cg00051068 hypermethylation cg00509431 hypermethylation cg00672622 hypermethylation cg00703260 hypermethylation cg00730653 hypermethylation cg00779206 hypomethylation cg00818872 hypermethylation cg00963169 hypermethylation cg01257697 hypomethylation cg01578017 hypermethylation cg01687680 hypermethylation cg01857475 hypermethylation cg01912921 hypermethylation cg01926051 hypermethylation cg02009103 hypomethylation cg02202980 hypermethylation cg02281208 hypermethylation cg02366534 hypermethylation cg02543075 hypermethylation cg02580404 hypermethylation cg02585329 hypomethylation cg02621087 hypomethylation cg02736548 hypermethylation cg02763101 hypermethylation cg02774439 hypermethylation cg02776664 hypermethylation cg02781660 hypermethylation cg02793262 hypomethylation cg02816003 hypermethylation cg03079395 hypermethylation cg03135061 hypermethylation cg03304610 hypermethylation cg03577655 hypermethylation cg03681341 hypermethylation cg03755177 hypermethylation cg03900143 hypermethylation cg03995857 hypermethylation cg04552500 hypermethylation cg04765098 hypermethylation cg05041351 hypermethylation cg05071974 hypermethylation cg05167782 hypermethylation cg05387146 hypermethylation cg05537380 hypermethylation cg05735180 hypermethylation cg05739757 hypermethylation cg05800683 hypermethylation cg05861567 hypermethylation cg05896042 hypermethylation cg06148685 hypermethylation cg06201642 hypermethylation cg06361272 hypermethylation cg06401579 hypermethylation cg06507551 hypermethylation cg06829686 hypermethylation cg06897264 hypermethylation cg07046818 hypermethylation cg07068756 hypermethylation cg07170170 hypermethylation cg07236840 hypermethylation cg07393734 hypermethylation cg07423205 hypermethylation cg07528097 hypermethylation cg07536926 hypermethylation cg07591403 hypermethylation cg07857792 hypermethylation cg07914084 hypermethylation cg08137080 hypermethylation cg08188890 hypermethylation cg08196032 hypermethylation cg08217227 hypermethylation cg08261094 hypermethylation cg08278357 hypermethylation cg08301572 hypermethylation cg08464824 hypermethylation cg08578136 hypermethylation cg08582485 hypermethylation cg08586541 hypermethylation cg08768621 hypermethylation cg08876441 hypermethylation cg09133028 hypermethylation cg09214254 hypermethylation cg09320690 hypermethylation cg09410607 hypermethylation cg09551147 hypermethylation cg09568464 hypermethylation cg09626193 hypermethylation cg09660227 hypermethylation cg09689137 hypermethylation cg09816912 hypermethylation cg09820321 hypermethylation cg09915444 hypermethylation cg09941406 hypermethylation cg10090985 hypermethylation cg10126205 hypermethylation cg10496614 hypomethylation cg10499901 hypomethylation cg10948359 hypermethylation cg10953508 hypermethylation cg11240634 hypermethylation cg11268739 hypermethylation cg11528176 hypermethylation cg11879354 hypermethylation cg11881313 hypermethylation cg12041459 hypomethylation cg12064507 hypomethylation cg12109455 hypermethylation cg12238343 hypermethylation cg12349858 hypermethylation cg12824796 hypermethylation cg13121699 hypermethylation cg13137176 hypermethylation cg13571707 hypermethylation cg13720108 hypermethylation cg13734972 hypermethylation cg13781853 hypermethylation cg13802571 hypermethylation cg13907049 hypermethylation cg14271531 hypermethylation cg14391419 hypermethylation cg14689219 hypermethylation cg14750948 hypermethylation cg14859204 hypermethylation cg14919250 hypermethylation cg15015920 hypermethylation cg15090727 hypermethylation cg15179725 hypermethylation cg15269503 hypermethylation cg15274684 hypermethylation cg15665646 hypermethylation cg15733114 hypomethylation cg15905200 hypermethylation cg15941948 hypermethylation cg16008327 hypomethylation cg16107001 hypermethylation cg16292016 hypermethylation cg16314401 hypermethylation cg16726869 hypomethylation cg16785755 hypermethylation cg17186168 hypermethylation cg17384889 hypermethylation cg17457560 hypermethylation cg17658822 hypermethylation cg17689721 hypermethylation cg17904852 hypermethylation cg18194306 hypermethylation cg18303215 hypermethylation cg18337337 hypermethylation cg18371475 hypermethylation cg18477587 hypomethylation cg18496965 hypomethylation cg18510056 hypermethylation cg18582992 hypermethylation cg18592273 hypermethylation cg18683691 hypomethylation cg18789663 hypermethylation cg19768329 hypermethylation cg19866478 hypermethylation cg19998368 hypermethylation cg20212699 hypermethylation cg20699736 hypermethylation cg20804050 hypermethylation cg20985450 hypermethylation cg21052682 hypermethylation cg21331461 hypermethylation cg21544416 hypomethylation cg21790626 hypermethylation cg22304068 hypermethylation cg22473973 hypermethylation cg22647407 hypermethylation cg22665696 hypermethylation cg22736850 hypermethylation cg22951989 hypermethylation cg23177772 hypermethylation cg23302998 hypomethylation cg23335460 hypermethylation cg23395449 hypermethylation cg23504474 hypermethylation cg23615676 hypermethylation cg23716800 hypermethylation cg23763043 hypermethylation cg23855989 hypermethylation cg23944251 hypermethylation cg24325551 hypomethylation cg24553673 hypermethylation cg24573501 hypermethylation cg24617723 hypermethylation cg25096566 hypermethylation cg25127852 hypermethylation cg25505069 hypermethylation cg25679870 hypermethylation cg25721451 hypermethylation cg25933341 hypermethylation cg25973534 hypermethylation cg26179400 hypomethylation cg26307359 hypermethylation cg26560222 hypermethylation cg26824006 hypermethylation cg26880493 hypermethylation cg26902216 hypermethylation cg26936429 hypermethylation cg27120816 hypermethylation cg27140220 hypermethylation cg27357571 hypermethylation cg27431596 hypermethylation cg27506082 hypermethylation cg27508144 hypermethylation cg27569742 hypermethylation cg06642177 hypermethylation cg07786668 hypermethylation cg17218495 hypermethylation cg00699486 hypomethylation cg03458344 hypermethylation cg07311024 hypomethylation cg08193363 hypomethylation cg10073091 hypomethylation cg11955541 hypomethylation cg21609024 hypomethylation cg23074119 hypermethylation cg23541257 hypomethylation Chr10:104245194 hypomethylation Chr10:119684380 hypermethylation Chr10:124386849 hypermethylation Chr10:131843808 hypomethylation Chr10:132965246 hypomethylation Chr10:15179837 hypermethylation Chr10:15214305 hypermethylation Chr10:29204054 hypomethylation Chr10:31950967 hypermethylation Chr10:42933638 hypomethylation Chr10:61000854 hypomethylation Chr10:68471699 hypomethylation Chr10:96089862 hypomethylation Chr10:988476 hypomethylation Chr11:104507506 hypermethylation Chr11:118690473 hypomethylation Chr11:11969221 hypermethylation Chr11:122980215 hypomethylation Chr11:129909240 hypermethylation Chr11:2858330 hypermethylation Chr11:3204320 hypomethylation Chr11:3204666 hypomethylation Chr11:47910009 hypomethylation Chr11:49977468 hypermethylation Chr11:61752535 hypomethylation Chr11:62925978 hypomethylation Chr11:62984817 hypermethylation Chr11:72590170 hypermethylation Chr12:111363321 hypermethylation Chr12:124583900 hypomethylation Chr12:18895722 hypermethylation Chr12:3294217 hypermethylation Chr13:110116187 hypomethylation Chr13:27964846 hypomethylation Chr13:31183198 hypermethylation Chr13:34832323 hypermethylation Chr13:94712105 hypomethylation Chr13:96969756 hypomethylation Chr14:101632750 hypomethylation Chr14:105287866 hypomethylation Chr14:32115522 hypermethylation Chr14:32938969 hypomethylation Chr14:34683973 hypermethylation Chr14:72674355 hypomethylation Chr14:75294288 hypermethylation Chr14:77006517 hypermethylation Chr14:91324759 hypermethylation Chr14:94109151 hypermethylation Chr14:96092229 hypomethylation Chr14:99831302 hypomethylation Chr16:1080385 hypermethylation Chr16:1181443 hypermethylation Chr16:19306004 hypomethylation Chr16:1978076 hypomethylation Chr16:24523563 hypermethylation Chr16:29174492 hypomethylation Chr16:3036041 hypomethylation Chr16:30998304 hypomethylation Chr16:64344110 hypermethylation Chr16:74976736 hypomethylation Chr16:801670 hypomethylation Chr16:84201874 hypomethylation Chr16:89700174 hypermethylation Chr17:1109545 hypomethylation Chr17:16215104 hypermethylation Chr17:39401585 hypermethylation Chr17:42458783 hypomethylation Chr17:43982953 hypermethylation Chr17:47072021 hypomethylation Chr17:48817034 hypermethylation Chr17:5034763 hypomethylation Chr17:50707807 hypomethylation Chr17:58366918 hypomethylation Chr17:72661608 hypermethylation Chr17:73276269 hypermethylation Chr17:75720445 hypomethylation Chr18:22041461 hypomethylation Chr18:29413308 hypomethylation Chr18:48973277 hypomethylation Chr18:49575382 hypermethylation Chr18:50845444 hypomethylation Chr18:51198304 hypermethylation Chr18:7195104 hypomethylation Chr18:78935011 hypermethylation Chr18:79403051 hypomethylation Chr19:10250849 hypomethylation Chr19:11645573 hypermethylation Chr19:1229605 hypermethylation Chr19:1260856 hypermethylation Chr19:17101994 hypermethylation Chr19:17390664 hypermethylation Chr19:17795389 hypomethylation Chr19:18292948 hypermethylation Chr19:18879119 hypomethylation Chr19:2235909 hypomethylation Chr19:30443719 hypermethylation Chr19:36033133 hypomethylation Chr19:3628528 hypomethylation Chr19:39314350 hypermethylation Chr19:43867210 hypermethylation Chr19:4479181 hypomethylation Chr19:45552676 hypomethylation Chr19:4676694 hypermethylation Chr19:55359429 hypermethylation Chr19:57119103 hypermethylation Chr19:6239377 hypomethylation Chr19:8522317 hypermethylation Chr19:9953412 hypermethylation Chr2:112055210 hypermethylation Chr2:112158870 hypermethylation Chr2:191882003 hypermethylation Chr2:201160969 hypermethylation Chr2:20624784 hypomethylation Chr2:218468786 hypomethylation Chr2:238114541 hypermethylation Chr2:239420657 hypermethylation Chr2:241802329 hypomethylation Chr2:2629264 hypermethylation Chr2:27583072 hypomethylation Chr2:29022260 hypomethylation Chr2:32946874 hypomethylation Chr2:3642500 hypermethylation Chr2:3698408 hypomethylation Chr2:47061699 hypomethylation Chr2:65127453 hypomethylation Chr2:72160574 hypermethylation Chr2:98388634 hypermethylation Chr20:18161030 hypermethylation Chr20:23205752 hypomethylation Chr20:32722446 hypermethylation Chr20:36498495 hypermethylation Chr20:43655560 hypomethylation Chr20:60104214 hypomethylation Chr20:61406893 hypermethylation Chr20:61931247 hypermethylation Chr20:62134895 hypomethylation Chr20:62476204 hypomethylation Chr20:63597815 hypomethylation Chr20:64057589 hypomethylation Chr21:36660840 hypermethylation Chr21:45480753 hypermethylation Chr21:46117451 hypermethylation Chr22:17085126 hypomethylation Chr22:24011318 hypomethylation Chr22:29307304 hypomethylation Chr22:30542074 hypomethylation Chr22:36465456 hypermethylation Chr22:37492706 hypomethylation Chr22:37745025 hypermethylation Chr22:37828716 hypomethylation Chr22:41227807 hypermethylation Chr22:41341465 hypermethylation Chr22:44219261 hypomethylation Chr22:46641040 hypomethylation Chr3:100417592 hypermethylation Chr3:11037618 hypomethylation Chr3:127392179 hypermethylation Chr3:13290659 hypermethylation Chr3:136196433 hypermethylation Chr3:149148563 hypomethylation Chr3:170038259 hypermethylation Chr3:191261938 hypomethylation Chr3:19351625 hypomethylation Chr3:194034365 hypermethylation Chr3:194730477 hypomethylation Chr3:195657977 hypomethylation Chr3:33439984 hypermethylation Chr3:38024472 hypomethylation Chr3:51713043 hypomethylation Chr3:64438933 hypermethylation Chr3:66406455 hypermethylation Chr3:66501190 hypermethylation Chr3:66545014 hypermethylation Chr3:87375514 hypermethylation Chr4:133941659 hypomethylation Chr4:13446557 hypomethylation Chr4:170046694 hypomethylation Chr4:184825590 hypermethylation Chr4:33710272 hypermethylation Chr4:3728294 hypermethylation Chr4:39609275 hypermethylation Chr4:4227293 hypomethylation Chr5:10520485 hypomethylation Chr5:126581545 hypermethylation Chr5:126594972 hypomethylation Chr5:134053541 hypomethylation Chr5:140838333 hypermethylation Chr5:162078566 hypomethylation Chr5:180664473 hypermethylation Chr5:181247049 hypomethylation Chr5:2004625 hypermethylation Chr6:105136498 hypomethylation Chr6:11994884 hypomethylation Chr6:133837186 hypermethylation Chr6:170176299 hypomethylation Chr6:29309704 hypermethylation Chr6:30104446 hypermethylation Chr6:30600758 hypomethylation Chr6:31013756 hypomethylation Chr6:34017205 hypermethylation Chr6:35831250 hypomethylation Chr6:4078347 hypermethylation Chr6:98554980 hypermethylation Chr6:9975751 hypomethylation Chr7:100708904 hypermethylation Chr7:101232768 hypomethylation Chr7:112205374 hypermethylation Chr7:130141131 hypomethylation Chr7:151199295 hypermethylation Chr7:157468326 hypermethylation Chr7:157684218 hypomethylation Chr7:1938829 hypomethylation Chr7:2069228 hypomethylation Chr7:2665066 hypermethylation Chr7:30759200 hypermethylation Chr7:56539077 hypermethylation Chr7:5856613 hypermethylation Chr7:74084359 hypermethylation Chr7:90497286 hypermethylation Chr7:98406650 hypermethylation Chr8:141805557 hypermethylation Chr8:142986959 hypomethylation Chr8:144327288 hypomethylation Chr8:17385811 hypermethylation Chr8:23007384 hypermethylation Chr8:57217447 hypermethylation Chr8:57756331 hypomethylation Chr8:73252863 hypermethylation Chr8:76787669 hypermethylation Chr9:114261576 hypermethylation Chr9:121201467 hypermethylation Chr9:128455869 hypermethylation Chr9:128702522 hypermethylation Chr9:129100188 hypermethylation Chr9:130480773 hypomethylation Chr9:132138072 hypermethylation Chr9:132198528 hypermethylation Chr9:133116311 hypermethylation Chr9:136136228 hypermethylation Chr9:136342477 hypermethylation Chr9:33025270 hypermethylation Chr9:34522812 hypermethylation Chr9:71875386 hypomethylation Chr9:72060140 hypomethylation Chr9:7786835 hypomethylation Chr9:80344759 hypermethylation Chr9:87604996 hypomethylation Chr9:95349469 hypomethylation ChrX:136836625 hypermethylation ChrX:137970665 hypomethylation ChrX:333103 hypomethylation ChrX:53248781 hypermethylation ChrX:54015298 hypermethylation ChrX:68602968 hypermethylation ChrX:68772487 hypermethylation ChrX:76429368 hypermethylation ChrX:77994631 hypermethylation ChrX:99888187 hypermethylation CHR9_ABO_CpG hypermethylation Within the MBL2 gene are seven 5' "secretor" haplotypes that code for altered serum MBL levels and complement activation.[PMID:17846289] MBL2 LYQA secretor haplotype NM_002203.4:c.[759C>T;873G>A] NM_003891.3:c.[-13A>G;-103G>A;-79G>A] NM_000024.6:c.[-47C>T;46G>A;79G>C] NC_000004.12:g.[154604818C>T;154590745A>G] NM_000078.3:c.[-2708G>A;-971A>G;-629A>C;118+279G>A;1264G>A] NM_002421.4:c.[-1607insG;-519A>G;-340T>C] NM_030578.4:c.[*18G>A;-509C>T;29C>T] NM_025144.4:c.[2608G>A;2746A>G] NM_001992.5:c.[-1738G>A;2860G>A] NM_000125.4:c.[453-397T>C;453-351A>G] NM_000769.4:c.[681G>A;636G>A] NM_001629.4:c.[70+18C>A;170+105T>A] NM_012238.5:c.[943-3428C>G;1090+207A>G;*480C>T] APOE is polymorphic, with three major alleles (epsilon 2, epsilon 3, and epsilon 4): APOE-E2 (cys112, cys158), APOE-E3 (cys112, arg158), and APOE-E4 (arg112, arg158). [url:https://en.wikipedia.org/wiki/Apolipoprotein_E] NM_000041.4:c.[526C>T;388T>C] NG_032899.2:g.[9781A>G;9859C>G] NM_000745.3:c.[107-1865T>C;1192G>A] NC_000001.11:g.[53272428C>T;53272511A>G] SG13S25-SG13S114-SG13S89-SG13S32 ALOX5AP haplotype NM_005141.5:c.[-455G>A;1433G>A;8558C>G] LPA [PN;KIV-2] NM_000024.6:c.[46G>A;79G>C;491C>T] NC_000007.14:g.[87509329A>T;87509216A>C;87515500G>C;87501081C>T] NC_000009.12:g.[22096056A>G;22115027A>G;22119196T>C;22124478A>G;22125504G>C] NC_000009.12:g.[22096056A>G;22115027A>G;22115960A>G;22124478A>G] NM_004631.5:c.[1007-1082C>T;1007-1165A>G] NC_000009.12:g.[22014138C>G;22018781T>A;22019674G>C;22024352C>T;22031006G>A] NC_000010.10:g.[112835159A>G;112836503C>G;112837073C>G;112837538G>A;112838552C>G;112838892C>A;112839282T>A;112839579C>T;g.112839601C>A;113042093G>T] NM_002421.4:c.[-1607insG;-340T>C] NC_000001.11:g.[55039995C>G;55039974G>A;55038977G>A;55030366T>C] NM_001437.3:c.[-789T>G;984G>A;*39G>A] NC_000006.12:g.[46736602C>T;46735776A>G;46735073A>G;46716485C>T;46711566A>G;46709361C>A;46705206A>G] NM_002052.3:c.[910-240C>T;946C>G;997+56C>A;1056C>T;1129A>G;*426C>T;*1158C>T] NC_000009.12:g.[22083405C>T;22098575A>G;22115960A>G;22125504G>C] NC_000009.12:g.[22125504G>C;22124478A>G] NM_005036.6:c.[-127+5156G>A;-127+7452C>A;-127+11398A>C] NM_001161352.2:c.[2027+37C>T;687C>T] NM_000852.4:c.[313A>G;341C>T] NM_002052.3:c.[909+1970A>G;910-240C>T;946C>G;997+56C>A] NM_002052.3:c.[909+1970A>G;910-240C>T;946C>G;997+56C>A;1056C>T;1129A>G;*426C>T] NM_002052.3:c.[909+1970A>G;910-240C>T;946C>G;997+56C>A;1056C>T;1129A>G;*426C>T;*1158C>T] NG_011963.2:g.[21351G>A;29482A>T;53431A>G;57503G>A] NC_000003.12:g.[46357717G>A;46373456_46373487del] NM_001378373.1:c.[161G>A;170G>A;154C>T;-9-281C>A] NM_000660.7:c.[-509C>T;29C>T;74G>C;788C>T] NM_000660.7:c.[-509C>T;29C>T] NM_001136.5:c.[-429T>C;-374T>A;244G>A] NG_007279.1:g.[5077T>C;6042T>G] NM_001562.4:c.[-656G>T;-105C>T;-8-1360A>G;91+488G>C;361-221C>A;*183A>G] NM_001562.4:c.[-656G>T;-119A>C;-9+3005A>G;-8-919G>A;-8-372C>G;361-221C>A] NG_012575.2:g.[7219A>G;14934G>A;22218C>G] NC_000017.11:g.[46896981T>C;46928464G>A;46931204G>A] NC_000006.12:g.[160442500T>C;160451754C>G;160486102C>T;160490021C>T;160493428A>G;160500534T>G;160519088A>G;160541471T>C;160548706C>G] NC_000006.12:g.[160442500T>C;160486102C>T;160541471T>C;160548706C>G] NC_000011.10:g.[14893764A>G;14888688A>G;14900334G>A] NC_000008.11:g.[58476006C>T;58500365A>C] NM_000618.5:c.[64-1682G>A;220+10605T>C;221-164G>A;403-5895A>G] NM_000618.5:c.[64-1682G>A;220+10605T>C;403-5895A>G;*2652T>C] NM_000602.5:c.[-844A>G;506-451G>A;1088-106A>G] NM_000602.5:c.[-844A>G;701-340G>A] NM_001992.5:c.[-1738G>A;-506GGCCGCGGGAAGC[3];2860G>A;88+693C>A;88+6876C>A;88+7096C>T;*1468T>C]*NM_000600.5:c.[-174G>C;-572G>C;324+147C>G] NM_000545.5:c.[1375C>T;1460T>C;1501+119G>T;*438A>G] NM_000545.5:c.[1375C>T;1460T>C;1501+119G>T;*438A>G;452+136C>T] NG_007932.1:g.[10733T>A;13661T>C;15254G>A] NC_000001.11:g.[59907994A>C;59920071C>T;59923002G>A] NM_001386809.1:c.[80-7C>T;368T>C;719-63G>T;*A>C] NM_002250.3:c.[820-60G>A;1049+78T>C;1120-487A>G] NM_000545.5:c.[327-2680C>T;327-1775A>G;1375C>T;1460T>C] NM_000545.5:c.[327-2680C>T;327-1775A>G;1375C>T;1460T>C;1501+119G>T] NM_000545.5:c.[327-2680C>T;327-1775A>G;1375C>T;1460T>C;1501+119G>T;*438A>G] NM_000545.5:c.[327-2680C>T;327-1775A>G;1375C>T;1460T>C;1501+119G>T;*438A>G;452+136C>T] NM_000545.5:c.[1460T>C;1501+119G>T;*438A>G;452+136C>T] NM_000040.3:c.[-641C>A;-482C>T;-455T>C;1100C>T;*40G>C;3206C>G] NM_002052.3:c.[909+1160C>T;909+1970A>G;910-240C>T;946C>G;997+56C>A;1056C>T;1129A>G;*426C>T] NM_002052.3:c.[909+1160C>T;909+1970A>G;910-240C>T;946C>G;997+56C>A;1056C>T;1129A>G;*426C>T;*1158C>T] NM_002052.3:c.[909+1160C>T;909+1970A>G;910-240C>T;946C>G;997+56C>A;1056C>T;1129A>G;*426C>T;*1158C>T;*1521C>G] NM_000685.5:c.[-1106A>T;-48+59A>G;-47-11020G>A;573C>T;*86A>C;*798G>A] NC_000005.10:g.[60174072G>A;60365629A>G;60206693A>G;60298071A>G;60304214G>C;60354709A>G] NC_000001.11:g.[222614720C>T;g.222617024G>A;222625623G>A;222633671C>T;222650187A>C;222658030A>G;222658668A>G;222661880A>C;222666496A>G] NM_001082.5:c.[344-979T>A;919-446C>T;1297G>A] NM_173841.3:c.[62+732G>A;117T>C;214+94T>G;399T>C;483+1061G>A] NM_000237.3:c.[1421C>G;106G>A;953A>G] NM_002422.5:c.[-1612dup;-376C>G;1161G>A] NM_000106.6:c.[775del;506-1G>A;100C>T] NM_002052.3:c.[1056C>T;1129A>G;*426C>T;*1158C>T;*1521C>G] NM_003326.5:c.[203-288A>G;202+119A>G;154-5804T>C;154-8539T>C] NM_004994.3:c.[-1562C>T;836A>G] NM_000769.4:c.[681G>A;636G>A;-806C>T] NM_000041.4:c.[-491A>T;388T>C] NM_000576.3:c.[-3737C>T;-1468G>C;-511C>T] NC_000005.10:g.[4022536T>C;4029676C>T;4035819G>A] NM_138554.5:c.[896A>G;1196C>T] NM_019616.4:c.[-670A>C;-323del;-122T>C;1172G>A] NM_000040.3:c.[*40G>C;-455T>C;-482C>T] NG_012100.1:g.[4295A>G;7762G>C;13685G>C;14446T>C] NM_000961.4:c.[*2479T>C;1117C>A;252C>T] NC_000019.10:g.[8311547G>A;49505441A>G;49510639T>C;49517245G>A;49524145C>G;49536138A>G;48177784G>A] NC_000023.11:g.[129656490A>G;129655744A>C;129653796C>T;129651324C>T;129648585G>T;129648435G>C;129652326T>C;129646415G>C] NM_002052.3:c.[946C>G;997+56C>A;1056C>T;1129A>G;*426C>T] NM_000173.7:c.[482C>T;-5T>C] NM_000602.5:c.[43G>A;*722T>G] NM_002575.3:c.[358A>G;1212C>G;1238C>G] NM_003005.4:c.[992G>A;1807G>A;1918G>T;2266A>C;2346G>T;2346G>T] NC_000002.12:g.[21008652G>A;21014914T>G;21021486T>G;21022457G>T;21003688A>G] NM_003376.6:c.[-2578A>C;-94C>G;*237C>T] NM_003376.6:c.[-2578A>C;-460C>T;-94C>G] NM_000583.4:c.[1296T>G;1307C>A] NM_000956.4:c.[-12813G>A;-10250T>A;-6179A>G] NM_001972.4:c.[-761G>A;4890C>A] NM_000545.5:c.[327-1775A>G;1375C>T;1460T>C;1501+119G>T] NM_000545.5:c.[327-1775A>G;1375C>T;1460T>C;1501+119G>T;*438A>G] NM_004631.5:c.[1007-1165A>G;1257C>A;2622C>T;2855G>A] NC_000014.9:g.[35225975T>A;35258383G>A;35292469C>G;35303372A>G;35340878A>G] NM_020469.3:c.[796C>A;526C>G] NM_004797.4:c.[-4033C>A;-11377C>G;-11391G>A;-3971A>G;45T>G;214+62G>T] NC_000012.12:g.[SG12S16A>G;96007474G>A;96009832T>C;96015423A>G; 96020673T>C;96028599T>C;96032219T>G;96041102C>T;96044775G>A;96047515G>A] NC_000001.11:g.[173206693A>G;173208097C>T] NM_000295.5:c.[710T>C;1096G>A] NM_000442.5:c.[373G>C;1688G>A;2008A>G] rsID:rs139876191 NM_145899.3:c.136-15_136-14del rs139876191 rsID:rs17240441 NM_000384.3:c.26TGGCGCTGC[1] rs17240441 rsID:rs1799752 The rs1799752 I/D polymorphism consists of either an insertion (I) or absence (D) of a 287 base pair alanine sequence in intron 16 of the gene.[url:https://en.wikipedia.org/wiki/Angiotensin-converting_enzyme] NM_000789.4:c.2306-105_2306-104insTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCATACAGTCACTTTT rs1799752 rsID:rs28362491 NG_050628.1:g.4670ATTG[1] rs28362491 rsID:rs28362691 NM_003998.4:c.-94delATTG rs28362691 rsID:rs28365031 NM_000682.7:c.893_900dup rs28365031 rsID:rs35068180 NM_002422.5:c.-1612dup rs35068180 rsID:rs5742910 NM_019616.4:c.-323insCCTATATCCT rs5742910 rsID:rs61722009 The large allele, NOS3 4b (420 base pairs), contains 5 tandem 27 bp repeat and the smaller allele, NOS3 4a (393 base pairs), contains 4 repeats.[PMID:11903359] NM_000603.5:c.582+290_582+343del rs61722009 rsID:rs71019893 NC_000011.10:g.236380_236381insCCCGCGGCGCCCCA rs71019893 rsID:rs774676466 The functional 44-base pair deletion/insertion polymorphism leads to the creation of short (S) and long(L) alleles. NG_011747.2:g.3628_3670dup rs774676466 Allele A yielded a fragment of 518 bp, allele B 479 bp, allele C 440 bp and allele D 401 bp. [PMID:22535530] GP1BA VNTR NM_000209.4:c.-108dupG The PCR product sizes ranging from 188鈥?98 were given a number designated by the size of the CA repeat. NM_000618.5:-841CA[n] At least 3 alleles have been identified: A, B, and C, displaying 16, 15, or 14 repeats; position: exon 2 [PMID:15459589] NM_003006.4:c.9583_12000dul NM_015120.4:c.73466485_73466720dupGAG dinucleotide CA repeat polymorphisms in ESR1 gen NM_000125.4:c.1174dupTA(n) 5'pentanucleotide TTTTA repeat (PNTR) polymorphism of apolipoprotein (a) [apo (a)] gene NM_000039.3:c.-1373dulTTTTA(n) ALOX5, VARIANT PROMOTER SP1 BINDING APOB 3'VNTR NC_000004.12:g.3525052_3532208del NC_000019.10:g.38900888_91delTAAA NM_000106.6:c.dup NM_000789.4:c.4656CT[2] NM_019101.3:c.-724del PLAT 311bp ins/del Haplogroup H is a human mitochondrial DNA (mtDNA) haplogroup. [url:https://en.wikipedia.org/wiki/Haplogroup_H_(mtDNA)] mtDNA haplogroup H silent allele of the C4B gene C4B*Q0 GSTM1 null genotype GSTT1 null genotype HLA-DRB1*01 Human haptoglobin (HP), a hemoglobin-binding glycoprotein containing two types of polypeptide chains, alpha and beta, in equimolar amounts linked by disulfide bonds, exists in three major phenotypes determined by the properties of the alpha chain: HP 1-1 (alpha1), HP 2-2 (alpha2), and HP 2-1 (alpha1 and alpha2).[PMID:16123372] HP genotype HLA-DQA1*02 HLA-DRB1*0101 HLA-DRB1*07 NM_000575.5:c. ABO locus O1 allele ABO locus B allele CYP2D6 frequency TRBJ2-1 frequency TRBV12-3 frequency TRBV2 frequency TRBV29-1 frequency TRBV30 frequency rsID:rs1007888 NR_038911.1:n.17G>A rs1007888 rsID:rs1010 NC_000007.14:g.87509329A>G rs1010 rsID:rs10116277 NC_000009.12:g.22081398G>T rs10116277 rsID:rs10191517 NC_000002.12:g.73331275G>A rs10191517 rsID:rs1024611 NM_002986.3:c.-2578G>A rs1024611 rsID:rs10306114 NM_000962.4:c.-842A>G rs10306114 rsID:rs1041981 NM_000595.4:c.179C>A rs1041981 rsID:rs1042031 EcoRI digestion yields two invariant bands of 1.7 kb and 1.2kb and reveals a 2 allele polymorphism consisting of either a band at 13 kb (R1) or 2 bands of 11 kb and 2.1 kb (R2).[PMID:3024002] NM_000384.3:c.12541G>T rs1042031 rsID:rs1042579 NM_000361.3:c.1418C>T rs1042579 rsID:rs1042711 NM_000024.6:c.-47C>T rs1042711 rsID:rs1042713 NM_000024.6:c.46G>A rs1042713 rsID:rs1042714 NM_000024.6:c.79G>C rs1042714 rsID:rs10428132 NC_000003.12:g.38736063T>G rs10428132 rsID:rs1044498 NM_006208.3:c.517A>C rs1044498 rsID:rs10455872 NC_000006.12:g.160589086A>G rs10455872 rsID:rs1045642 NM_000927.5:c.3435T>C rs1045642 rsID:rs10487667 NG_008422.2:g.210863T>G rs10487667 rsID:rs1048990 NM_002791.3:c.-8C>G rs1048990 rsID:rs1049255 NG_007291.1:g.12721G>A rs1049255 rsID:rs10507391 NG_011963.2:g.29482A>T rs10507391 rsID:rs1050998 NM_001386809.1:c.368T>C rs1050998 rsID:rs1051931 NM_005084.4:c.1136T>C rs1051931 rsID:rs1053874 NM_005223.4:c.731G>A rs1053874 rsID:rs1057910 NM_000771.4:c.1075A>C rs1057910 rsID:rs1058932 NG_007972.1:g.37394C>T rs1058932 rsID:rs1059369 NM_004864.4:c.142T>A rs1059369 rsID:rs1061170 NM_000186.4:c.1204C>T rs1061170 rsID:rs1063192 NC_000009.12:g.22003368G>A rs1063192 rsID:rs10738605 NR_003529.3:n.1155C>G rs10738605 rsID:rs10750097 NC_000011.10:g.116793324G>A rs10750097 rsID:rs10757274 NC_000009.12:g.22096056A>G rs10757274 rsID:rs10757278 NC_000009.12:g.22124478A>G rs10757278 rsID:rs1076991 NM_005956.4:c.-105C>T rs1076991 rsID:rs10770704 NM_017435.5:c.271+1368T>C rs10770704 rsID:rs10773989 NM_024551.3:c.-86-6442T>C rs10773989 rsID:rs10811650 NC_000009.12:g.22067594A>G rs10811650 rsID:rs10830963 NM_005959.5:c.223+5596C>G rs10830963 rsID:rs10846744 NM_005505.5:c.127-10172C>G rs10846744 rsID:rs10885122 NC_000010.11:g.111282335T>G rs10885122 rsID:rs10889160 NC_000001.11:g.59896449T>C rs10889160 rsID:rs10890 NG_008845.2:g.42446C>T rs10890 rsID:rs10898909 NM_002564.4:c.*6158G>A rs10898909 rsID:rs10920501 NC_000001.11:g.190092815A>T rs10920501 rsID:rs10920722 NC_000001.11:g.190458964A>T rs10920722 rsID:rs10920725 NC_000001.11:g.190471407T>C rs10920725 rsID:rs10965215 NR_003529.3:n.385G>A rs10965215 rsID:rs11053646 NM_002543.4:c.501G>C rs11053646 rsID:rs11066001 NM_006768.5:c.443+270A>G rs11066001 rsID:rs11091046 NM_000686.5:c.3123C>A rs11091046 rsID:rs11206244 NM_000792.7:c.*29C>T rs11206244 rsID:rs11206510 NC_000001.11:g.55030366T>C rs11206510 rsID:rs11225490 NM_002427.4:c.799+92A>G rs11225490 rsID:rs1122608 NM_001128849.3:c.4521-5330G>T rs1122608 rsID:rs112443954 NC_000006.12:g.13574259G>C rs112443954 rsID:rs11246029 NC_000011.10:g.236473C>T rs11246029 rsID:rs1126643 NM_002203.4:c.759C>T rs1126643 rsID:rs1129844 NM_002986.3:c.67G>A rs1129844 rsID:rs1130864 NG_013007.1:g.6289C>T rs1130864 rsID:rs1131012 NM_000442.5:c.2008A>G rs1131012 rsID:rs1131239 NM_001154.4:c.-1C>T rs1131239 rsID:rs1131824 NM_001161352.2:c.687C>T rs1131824 rsID:rs1137100 NM_002303.6:c.326A>G rs1137100 rsID:rs1137101 NM_002303.6:c.668A>G rs1137101 rsID:rs1140713 NM_016215.5:c.572-117C>T rs1140713 rsID:rs1143623 NM_000576.3:c.-1468G>C rs1143623 rsID:rs1143629 NC_000002.12:g.112835941G>A rs1143629 rsID:rs1143634 NM_000576.3:c.315C>T rs1143634 rsID:rs1144393 NM_002421.4:c.-519A>G rs1144393 rsID:rs1151640 NM_001005487.2:c.394A>G rs1151640 rsID:rs11568732 NM_000769.4:c.-889T>G rs11568732 rsID:rs11568821 NG_012110.1:g.12147G>A rs11568821 rsID:rs11572325 NC_000001.11:g.59896030A>T rs11572325 rsID:rs11581737 NC_000001.11:g.190491143G>A rs11581737 rsID:rs11591147 NM_174936.4:c.137G>A rs11591147 rsID:rs11614913 NR_029617.1:n.78C>T rs11614913 rsID:rs11666735 NM_002000.4:c.337G>A rs11666735 rsID:rs11708996 NC_000003.12:g.38592432G>C rs11708996 rsID:rs11720524 NM_198056.3:c.-52-562G>C rs11720524 rsID:rs11748327 NC_000005.10:g.4029676C>T rs11748327 rsID:rs118203908 NM_000130.5:c.2401C>T rs118203908 rsID:rs11881940 NC_000019.10:g.41302527A>T rs11881940 rsID:rs11932595 NM_004898.4:c.793-1130T>C rs11932595 rsID:rs1197387160 NC_000006.12:g.13574131C>A rs1197387160 rsID:rs12026 NM_000305.3:c.443C>G rs12026 rsID:rs12095080 NM_000792.7:c.*1058A>G rs12095080 rsID:rs12190287 NG_032121.1:g.9267C>G rs12190287 rsID:rs121909548 NM_000488.4:c.1246G>T rs121909548 rsID:rs121912703 NM_000789.4:c.3683C>T rs121912703 rsID:rs12218 NM_000331.6:c.288T>C rs12218 rsID:rs12248560 NM_000769.4:c.-806C>T rs12248560 rsID:rs12316150 NM_002543.4:c.*188C>T rs12316150 rsID:rs12363415 NM_001178.6:c.1411+333A>G rs12363415 rsID:rs12373237 NM_198129.4:c.3720-325G>A rs12373237 rsID:rs12413409 NM_017649.5:c.1621+39238G>A rs12413409 rsID:rs12510359 NM_001166108.2:c.1964+44318A>G rs12510359 rsID:rs12526453 NM_030948.6:c.251-126053C>G rs12526453 rsID:rs1256049 NM_001437.3:c.984G>A rs1256049 rsID:rs12629945 NG_021140.1:g.21665G>A rs12629945 rsID:rs12632110 NM_004186.5:c.1947+46A>G rs12632110 rsID:rs12645561 NC_000004.12:g.177339718C>T rs12645561 rsID:rs1271572 NM_001437.3:c.-789T>G rs1271572 rsID:rs12724000 NC_000001.11:g.190382547C>T rs12724000 rsID:rs12746200 NM_024420.3:c.115+9538A>G rs12746200 rsID:rs12762303 NG_011437.1:g.4543T>C rs12762303 rsID:rs12953 NM_000442.5:c.1688G>A rs12953 rsID:rs13124436 NC_000004.12:g.55502504G>A rs13124436 rsID:rs1319501 NC_000007.14:g.106285307C>T rs1319501 rsID:rs13210247 NM_147686.4:c.-9+4259T>C rs13210247 rsID:rs13210554 NC_000006.12:g.46736602C>T rs13210554 rsID:rs13290387 NM_002581.5:c.2233+95G>C rs13290387 rsID:rs1333040 NC_000009.12:g.22083405C>T rs1333040 rsID:rs1333042 NC_000009.12:g.22103814A>G rs1333042 rsID:rs1333045 NC_000009.12:g.22119196T>C rs1333045 rsID:rs1333049 NC_000009.12:g.22125504G>C rs1333049 rsID:rs135551 NM_005036.6:c.-127+5156G>A rs135551 rsID:rs1361600 NM_001993.5:c.-603A>G rs1361600 rsID:rs1376251 NC_000012.12:g.10986253C>T rs1376251 rsID:rs1412444 NC_000010.11:g.89243170C>T rs1412444 rsID:rs1415294346 NC_000019.10:g.38900270A>G rs1415294346 rsID:rs1501299 NM_004797.4:c.214+62G>T rs1501299 rsID:rs1515777 NM_017435.5:c.405-747A>G rs1515777 rsID:rs1537378 NC_000009.12:g.22061615C>T rs1537378 rsID:rs1544410 The BsmI restriction polymorphism reveals two possible alleles, the allele B (absence of restriction site) and b (presence of restriction site).[PMID:16207551] NM_000376.3:c.1024+283G>T rs1544410 rsID:rs1548357 NM_006440.5:c.50964T>C rs1548357 rsID:rs1558861 NC_000011.10:g.116736721C>T rs1558861 rsID:rs1613662 NM_001083899.2:c.13254T>C rs1613662 rsID:rs1671021 NC_000017.11:g.75569090A>G rs1671021 rsID:rs1675225 NM_005215.4:c.92-120346C>T rs1675225 rsID:rs168753 NG_032906.1:g.21257A>T rs168753 rsID:rs16893344 NM_003882.4:c.69+2823C>T rs16893344 rsID:rs16944 NM_000576.3:c.-511C>T rs16944 rsID:rs1695 NM_000852.4:c.313A>G rs1695 rsID:rs16969968 NM_000745.3:c.1192G>A rs16969968 rsID:rs17128183 NC_000014.9:g.55112795A>G rs17128183 rsID:rs17181314 NM_001061.7:c.1134+2566A>C rs17181314 rsID:rs17222842 NG_011963.2:g.57503G>A rs17222842 rsID:rs17251221 NM_000388.4:c.1378-1412A>G rs17251221 rsID:rs17300539 NM_004797.4:c.-11391G>A rs17300539 rsID:rs1746048 NC_000010.11:g.44280376C>T rs1746048 rsID:rs17465637 NM_198551.4:c.3632-105A>C rs17465637 rsID:rs17576 NM_004994.3:c.836A>G rs17576 rsID:rs1758276984 NC_000006.12:g.13574287G>C rs1758276984 rsID:rs17602729 NM_000036.3:c.34C>T rs17602729 rsID:rs1764391 NM_002060.3:c.955C>T rs1764391 rsID:rs17708087 NC_000017.11:g.40514261A>G rs17708087 rsID:rs17817449 NC_000016.10:g.53767042T>G rs17817449 rsID:rs17883901 NM_001498.4:c.-129C>T rs17883901 rsID:rs1799722 NM_000623.4:c.-58T>C rs1799722 rsID:rs1799750 NC_000011.10:g.102799765C>G rs1799750 rsID:rs1799837 NM_000039.3:c.-21+68G>A rs1799837 rsID:rs1799858 NC_000011.10:g.17428382C>T rs1799858 rsID:rs1799864 NM_001123396.4:c.190G>A rs1799864 rsID:rs1799883 NM_000134.4:c.163A>G rs1799883 rsID:rs1799889 NM_000602.5:c.-675A>G rs1799889 rsID:rs1799895 NM_003102.4:c.691C>G rs1799895 rsID:rs1799963 NM_000506.5:c.*97G>A rs1799963 rsID:rs1799964 NM_000594.4:c.-1031T>C rs1799964 rsID:rs1799983 NM_000603.5:c.894T>G rs1799983 rsID:rs1799987 NM_000579.4:c.-301+246A>G rs1799987 rsID:rs1800206 NM_005036.6:c.484C>G rs1800206 rsID:rs1800469 NM_000660.7:c.-509C>T rs1800469 rsID:rs1800470 NM_000660.7:c.29C>T rs1800470 rsID:rs1800471 NM_000660.7:c.74G>C rs1800471 rsID:rs1800472 NM_000660.7:c.788C>T rs1800472 rsID:rs1800544 NG_012020.1:g.4714G>C rs1800544 rsID:rs1800562 NM_000410.4:c.845G>A rs1800562 rsID:rs1800588 NM_000236.3:c.-514C>T rs1800588 rsID:rs1800624 NM_001136.5:c.-374T>A rs1800624 rsID:rs1800625 NM_001136.5:c.-429T>C rs1800625 rsID:rs1800629 NM_000594.3:c.-488G>A rs1800629 rsID:rs1800630 NM_000594.4:c.-863C>A rs1800630 rsID:rs1800682 NM_000043.6:c.-670G>A rs1800682 rsID:rs1800683 NM_000595.4:c.-162G>A rs1800683 rsID:rs1800775 NM_000078.3:c.-629C>A rs1800775 rsID:rs1800787 NM_005141.5:c.-148C>T rs1800787 rsID:rs1800788 NM_005141.5:c.-249C>T rs1800788 rsID:rs1800790 NM_005141.5:c.-455G>A rs1800790 rsID:rs1800795 NM_000600.5:c.-174G>C rs1800795 rsID:rs1800796 NM_000600.5:c.-572G>C rs1800796 rsID:rs1800808 NM_003005.4:c.-1817T>C rs1800808 rsID:rs1800888 NM_000024.6:c.491C>T rs1800888 rsID:rs1800896 NM_000572.3:c.-1082A>G rs1800896 rsID:rs1800947 NM_000567.3:c.552G>C rs1800947 rsID:rs1801020 NM_000505.4:c.-4T>C rs1801020 rsID:rs1801058 NM_182982.3:c.1457T>C rs1801058 rsID:rs1801131 NM_005957.5:c.1286A>C rs1801131 rsID:rs1801133 NM_005957.5:c.665C>T rs1801133 rsID:rs1801157 NM_199168.4:c.801G>A rs1801157 rsID:rs1801177 NM_000237.3:c.106G>A rs1801177 rsID:rs1801252 NM_000684.3:c.145A>G rs1801252 rsID:rs1801253 NM_000684.3:c.1165G>C rs1801253 rsID:rs1801278 NM_005544.3:c.2911G>A rs1801278 rsID:rs1801282 NM_015869.5:c.34C>G rs1801282 rsID:rs1801701 A G- to A-DNA sequence change in exon 26 of the human apolipoprotein B (apo B) gene leads to a glutamine substitution for arginine at codon 3611 of the mature apolipo-protein B100 and causes a loss of an MspI site. MspI digestion gives 3 invariant bands of 7.8 kb, 6.8 kb and 2.8 kb and detects a 2 allele polymorphism resulting in bands at either 2.6kb (ID1) or 2.35 kb (ID2).[PMID:2472350;PMID:3024002] NM_000384.3:c.10913G>A rs1801701 rsID:rs1801708 NM_001957.4:c.-231A>G rs1801708 rsID:rs1801725 NM_000388.4:c.2956G>T rs1801725 rsID:rs1805010 NM_000418.4:c.223A>G rs1805010 rsID:rs1805123 NM_000238.4:c.2690A>C rs1805123 rsID:rs1805193 NM_000450.2:c.98G>T rs1805193 rsID:rs180797 NM_000600.5:c.-598G>A rs180797 rsID:rs1834481 NM_001562.4:c.91+488G>C rs1834481 rsID:rs184003 NM_001136.5:c.1704C>T rs184003 rsID:rs185277566 NC_000011.10:g.236370C>G rs185277566 rsID:rs1866389 NM_003248.6:c.1159G>C rs1866389 rsID:rs188212047 NM_001272034.2:c.636G>T rs188212047 rsID:rs1891586 NC_000001.11:g.190194864T>G rs1891586 rsID:rs1892028 NG_007556.1:g.15165C>G rs1892028 rsID:rs1926447 NM_001872.5:c.1040C>T rs1926447 rsID:rs1927911 NG_011475.2:g.8374A>G rs1927911 rsID:rs1946518 NM_001562.4:c.-607C>T rs1946518 rsID:rs1946519 NM_001562.4:c.-656G>T rs1946519 rsID:rs1978124 NG_012575.2:g.7219A>G rs1978124 rsID:rs2000813 NM_006033.4:c.332C>T rs2000813 rsID:rs2010963 NM_003376.6:c.-94C>G rs2010963 rsID:rs203462 NM_007202.4:c.1936A>G rs203462 rsID:rs20417 NM_000963.4c.-765G>C rs20417 rsID:rs2043055 NM_001562.4:c.-9+3005A>G rs2043055 rsID:rs2043556 NC_000010.11:g.51299646A>G rs2043556 rsID:rs20455 NM_145027.6:c.2155T>C rs20455 rsID:rs20541 NM_002188.3:c.431A>G rs20541 rsID:rs20579 NM_000234.3:c.-7C>T rs20579 rsID:rs2059806 NM_000208.4:c.1650G>A rs2059806 rsID:rs2065501 NC_000009.12:g.22140225A>C rs2065501 rsID:rs2066714 NM_005502.4:c.2649A>G rs2066714 rsID:rs2069514 NM_000761.5:c.-2964G>A rs2069514 rsID:rs2070744 NM_000603.5:c.-51-762C>T rs2070744 rsID:rs2071559 NM_002253.4:c.-604T>C rs2071559 rsID:rs2071592 NG_012344.1:g.5713T>A rs2071592 rsID:rs2071746 NM_002133.3:c.-413T>A rs2071746 rsID:rs2074380 NM_025144.4:c.2608G>A rs2074380 rsID:rs2074381 NM_025144.4:c.2746A>G rs2074381 rsID:rs2107538 NM_002985.3:c.-403G>A rs2107538 rsID:rs2108622 NM_001082.5:c.1297G>A rs2108622 rsID:rs2213948 NC_000001.11:g.158880164C>G rs2213948 rsID:rs2227631 NM_000602.5:c.-844G>A rs2227631 rsID:rs2227744 NM_001992.5:c.-1738G>A rs2227744 rsID:rs2228044 NM_002184.4:c.442G>C rs2228044 rsID:rs2228262 NM_003246.4:c.2099A>G rs2228262 rsID:rs2228314 NM_004599.4:c.1784G>C rs2228314 rsID:rs2230806 NM_005502.4:c.656G>A rs2230806 rsID:rs2231142 NM_004827.3:c.421C>A rs2231142 rsID:rs2234693 NM_000125.4:c.453-397T>C rs2234693 rsID:rs2235309 NC_000023.11:g.129651324C>T rs2235309 rsID:rs2235310 NC_000023.11:g.129652326T>C rs2235310 rsID:rs2236225 NM_005956.4:c.1958G>A rs2236225 rsID:rs2237557 NC_000007.14:g.86763295C>A rs2237557 rsID:rs2239527 NM_004640.7:c.-23C>G rs2239527 rsID:rs2241766 NM_004797.4:c.45T>G rs2241766 rsID:rs2243250 NM_000589.4:c.-589C>T rs2243250 rsID:rs2245803 NM_004771.4:c.53A>C rs2245803 rsID:rs2246833 NC_000010.11:g.89246097C>T rs2246833 rsID:rs2247570 NM_000895.3:c.290+456A>G rs2247570 rsID:rs225014 NM_013989.5:c.274A>G rs225014 rsID:rs225015 NM_013989.5:c.*1453C>T rs225015 rsID:rs2259816 NM_000545.8:c.1501+119G>T rs2259816 rsID:rs2259820 NM_000545.8:c.1375C>T rs2259820 rsID:rs2265670 NC_000001.11:g.190202510G>C rs2265670 rsID:rs2271800 NC_000001.11:g.59907994A>C rs2271800 rsID:rs2274273 NC_000014.9:g.55147918C>T rs2274273 rsID:rs2284659 NG_012213.1:g.2713T>G rs2284659 rsID:rs2285053 NM_001127891.3:c.-735C>T rs2285053 rsID:rs2286797 NM_002217.4:c.108G>A rs2286797 rsID:rs2292912 NC_000011.10:g.45856137C>G rs2292912 rsID:rs2293303 NM_001904.4:c.2340C>T rs2293303 rsID:rs2301523 NR_003491.3:n.1505G>A rs2301523 rsID:rs2302685 NC_000012.12:g.12148964C>T rs2302685 rsID:rs2306799 NM_002250.3:c.820-60G>A rs2306799 rsID:rs2307240 NM_001266.5:c.224G>A rs2307240 rsID:rs231775 NM_005214.5:c.49A>G rs231775 rsID:rs2331291 NG_016621.2:g.10376C>T rs2331291 rsID:rs2383206 NC_000009.12:g.22115027A>G rs2383206 rsID:rs2383207 NC_000009.12:g.22115960A>G rs2383207 rsID:rs2419370 NC_000001.11:g.190139751C>T rs2419370 rsID:rs2422493 NM_005502.4:c.-565C>T rs2422493 rsID:rs2430561 NM_000619.3:c.+874T>A rs2430561 rsID:rs243865 NM_001127891.3:c.-1306C>T rs243865 rsID:rs243866 NM_001127891.3:c.-1575G>A rs243866 rsID:rs2464196 NM_000545.8:c.1460G>A rs2464196 rsID:rs2540487 NM_000895.3:c.88-6820C>T rs2540487 rsID:rs2569190 NM_000591.4:c.-260C>T rs2569190 rsID:rs2569512 NG_029220.1:g.30226T>C rs2569512 rsID:rs264 NM_000237.3:c.776-172G>A rs264 rsID:rs266729 NM_004797.4:c.-11377C>G rs266729 rsID:rs27135 NM_001992.5:c.2860G>A rs27135 rsID:rs275651 NM_000685.5:c.-810T>A rs275651 rsID:rs2781666 NG_007086.2:g.4195G>T rs2781666 rsID:rs2794521 NM_000567.3:c.-717A>G rs2794521 rsID:rs2804924 NC_000006.12:g.13574110G>A rs2804924 rsID:rs281865545 NM_000442.5:c.373G>C rs281865545 rsID:rs28357984 NC_012920.1:m.5178C>A rs28357984 rsID:rs28383653 NM_005958.4:c.497G>A rs28383653 rsID:rs2890565 NM_021995.2:c.266G>A rs2890565 rsID:rs2891168 NC_000009.12:g.22098620A>G rs2891168 rsID:rs28929474 NM_000295.5:c.1096G>A rs28929474 rsID:rs2895811 NG_051108.1:g.68130T>C rs2895811 rsID:rs2995300 NM_001109.5:c.*137T>G rs2995300 rsID:rs3087456 NM_000246.4:c.-168A>G rs3087456 rsID:rs3135506 NM_001371904.1:c.56C>G rs3135506 rsID:rs3136558 NC_000002.12:g.112833698A>G rs3136558 rsID:rs320 Digestion in the presence of the restriction sites resulted in two fragments of 205 and 160 bp (H2 allele), whereas absence of the restriction site resulted in a fragment of 365 bp (H1 allele). [PMID:21499891] NM_000237.3:c.1322+483T>A rs320 rsID:rs3200401 NR_002819.4:n.6624C>T rs3200401 rsID:rs3217986 NM_004936.4:c.*656A>C rs3217986 rsID:rs324420 NM_001441.3:c.385C>A rs324420 rsID:rs324640 NC_000007.14:g.137004249T>C rs324640 rsID:rs328 NM_000237.3:c.1421C>G rs328 rsID:rs333 NM_001394783.1:c.554_585del rs333 rsID:rs33980500 NM_147686.4:c.28G>A rs33980500 rsID:rs34097845 NM_000250.2:c.-129G>A rs34097845 rsID:rs3480 NC_000001.11:g.32862564G>A rs3480 rsID:rs35333999 NC_000002.12:g.238253316C>T rs35333999 rsID:rs35335161 NM_000552.5:c.7682T>A rs35335161 rsID:rs35594137 NG_009369.2:g.4982G>A rs35594137 rsID:rs35829419 NM_004895.5:c.2113C>A rs35829419 rsID:rs360717 NM_001562.4:c.-105C>T rs360717 rsID:rs36228499 NM_004064.5:c.-838C>A rs36228499 rsID:rs3730358 NM_005163.2:c.175+18C>T rs3730358 rsID:rs3732378 NM_001337.4:c.839C>T rs3732378 rsID:rs3732379 NM_001337.4:c.745G>A rs3732379 rsID:rs3739998 NM_001350001.2:c.2591G>C rs3739998 rsID:rs3742207 NM_001845.6:c.4002A>C rs3742207 rsID:rs3745601 NM_002566.5:c.259G>A rs3745601 rsID:rs3746444 NR_030223.1:n.73A>G rs3746444 rsID:rs3760905 NG_047153.1:g.4658C>A rs3760905 rsID:rs3765124 NM_014479.3:c.1331A>G rs3765124 rsID:rs3782886 NM_006768.5:c.723A>G rs3782886 rsID:rs3788979 NM_001935.4:c.366+1153G>A rs3788979 rsID:rs3789327 NM_001178.6:c.460-1731A>G rs3789327 rsID:rs3793456 NM_000144.5:c.384+4857G>A rs3793456 rsID:rs3798220 NM_005577.4:c.5673A>G rs3798220 rsID:rs3801150 NM_001061.7:c.1135-21195C>T rs3801150 rsID:rs3803915 NC_000019.10:g.2160530C>A rs3803915 rsID:rs3804100 NM_001318787.2:c.1350T>C rs3804100 rsID:rs3807989 NM_001753.5:c.196-12759A>G rs3807989 rsID:rs3812316 NM_032951.3:c.723G>C rs3812316 rsID:rs3813135 NC_000019.10:g.15476534T>C rs3813135 rsID:rs3825807 NM_014272.5:c.640T>C rs3825807 rsID:rs3846663 NM_000859.3:c.2458-84C>T rs3846663 rsID:rs3850641 NM_003326.5:c.153+331T>C rs3850641 rsID:rs3856806 NM_138711.6:c.1341C>T rs3856806 rsID:rs3882891 NM_001562.4:c.361-221C>A rs3882891 rsID:rs3918242 NM_004994.3:c.-1562C>T rs3918242 rsID:rs397514689 NM_000789.4:c.2371C>T rs397514689 rsID:rs402007 NC_000021.9:g.26845001C>G rs402007 rsID:rs405509 NM_000041.4:c.-219G>T rs405509 rsID:rs4065 NM_002658.6:c.*141C>T rs4065 rsID:rs4149584 NM_001065.4:c.362G>A rs4149584 rsID:rs4220 NM_005141.5:c.1433G>A rs4220 rsID:rs4244285 NM_000769.4:c.681G>A rs4244285 rsID:rs4253623 NM_005036.6:c.-127+2233A>G rs4253623 rsID:rs4291 NM_000789.4:c.-240A>T rs4291 rsID:rs429358 NM_000041.4:c.388T>C rs429358 rsID:rs4343 NM_000789.4:c.2328G>A rs4343 rsID:rs4359565 NG_047153.1:g.3915T>C rs4359565 rsID:rs4532 NM_000794.5:c.-48A>G rs4532 rsID:rs45454293 NC_000001.11:g.173208097C>T rs45454293 rsID:rs4618210 NM_001144382.2:c.3205-6841A>G rs4618210 rsID:rs4624606 NM_002182.4:c.1051+6959A>T rs4624606 rsID:rs4636297 NC_000009.12:g.136670698A>G rs4636297 rsID:rs4646142 NG_012575.2:g.22218C>G rs4646142 rsID:rs46522 NM_023079.5:c.390+355C>T rs46522 rsID:rs4673 NM_000101.4:c.214T>C rs4673 rsID:rs4680 NM_000754.4:c.472G>A rs4680 rsID:rs4704397 NM_003719.5:c.339+11353G>A rs4704397 rsID:rs4725563 NM_001061.7:c.539+1001C>T rs4725563 rsID:rs475007 NM_002421.4:c.-422A>T rs475007 rsID:rs4762 NM_001384479.1:c.593C>T rs4762 rsID:rs4764478 NM_000552.5:c.7729+252A>T rs4764478 rsID:rs4773144 NM_001846.4:c.99+242A>G rs4773144 rsID:rs4789932 NM_003255.5:c.-2803T>C rs4789932 rsID:rs4804611 NC_000019.10:g.11617987A>G rs4804611 rsID:rs480692 NC_000001.11:g.190290531T>C rs480692 rsID:rs4808793 NM_004864.4:c.-3148C>G rs4808793 rsID:rs4848306 NM_000576.3:c.-3737C>T rs4848306 rsID:rs4880 NM_000636.4:c.47T>C rs4880 rsID:rs490556 NC_000005.10:g.4022536T>C rs490556 rsID:rs4917 NM_001622.4:c.743T>C rs4917 rsID:rs4918 NM_001622.4:c.767G>C rs4918 rsID:rs4961 NM_001354761.2:c.1378G>T rs4961 rsID:rs4977574 NC_000009.12:g.22098575A>G rs4977574 rsID:rs4986790 NM_138554.5:c.896A>G rs4986790 rsID:rs4986938 NM_001437.3:c.*39G>A rs4986938 rsID:rs4994 NM_000025.3:c.190T>C rs4994 rsID:rs501120 NC_000010.11:g.44258419A>G rs501120 rsID:rs5065 NM_006172.4:c.454T>C rs5065 rsID:rs5069 NM_000039.3:c.-21+67C>T rs5069 rsID:rs5070 NM_000039.3:c.43+41T>C rs5070 rsID:rs510317 NM_019616.4:c.-402G>A rs510317 rsID:rs512692 NG_021159.1:g.405T>A rs512692 rsID:rs5128 Digestion in the presence of the restriction sites resulted in two fragments of 225 bp and 371 bp (S2 allele) whereas absence of the restriction site resulted in a fragment of 596 bp (S1 allele). [PMID:21767760] NM_000040.3:c.*40G>C rs5128 rsID:rs5174 NM_004631.5:c.2855G>A rs5174 rsID:rs5182 NM_000685.5:c.573C>T rs5182 rsID:rs5186 NM_000685.5:c.*86A>C rs5186 rsID:rs521660 NC_000005.10:g.4035819G>A rs521660 rsID:rs5361 NM_000450.2:c.445A>C rs5361 rsID:rs5443 NM_002075.4:c.825C>T rs5443 rsID:rs5498 NM_000201.3:c.1405A>G rs5498 rsID:rs5517 NM_002257.4:c.556A>G rs5517 rsID:rs56204867 NC_000023.11:g.129656490A>G rs56204867 rsID:rs56260937 NM_001080471.3:c.3108C>T rs56260937 rsID:rs5629 NM_000961.4:c.1117C>A rs5629 rsID:rs564398 NR_003529.3:n.487T>C rs564398 rsID:rs57137919 NM_016818.3:c.-376C>T rs57137919 rsID:rs57301765 NC_000007.14:g.19013110G>A rs57301765 rsID:rs573515169 NC_000006.12:g.13573450A>G rs573515169 rsID:rs5744241 NM_001562.4:c.-8-1360A>G rs5744241 rsID:rs5744292 NM_001562.4:c.*183A>G rs5744292 rsID:rs5752375 NG_016621.2:g.4063T>C rs5752375 rsID:rs580253 NC_000011.10:g.105029761G>A rs580253 rsID:rs5882 NM_000078.3:c.1264G>A rs5882 rsID:rs5888 NM_005505.5:c.1050T>C rs5888 rsID:rs5896 NM_000506.5:c.494C>T rs5896 rsID:rs5911 NM_000419.5:c.2621T>G rs5911 rsID:rs5918 NM_000212.3:c.176T>C rs5918 rsID:rs5985 NM_000129.4:c.103G>T rs5985 rsID:rs599839 NC_000001.11:g.109279544G>A rs599839 rsID:rs6003 NM_001994.3:c.344G>A rs6003 rsID:rs6025 NM_000130.5:c.1601G>A rs6025 rsID:rs6039 NM_019616.4:c.64+9G>A rs6039 rsID:rs6046 NM_019616.4:c.1172G>A rs6046 rsID:rs6060566 NM_080748.3:c.132-494T>C rs6060566 rsID:rs6065 NM_000173.7:c.482C>T rs6065 rsID:rs6080699 NM_002594.5:c.886-101G>C rs6080699 rsID:rs6125 NM_003005.4:c.625G>A rs6125 rsID:rs6131 NM_003005.4:c.992G>A rs6131 rsID:rs6136 NM_003005.4:c.2266A>C rs6136 rsID:rs61688134 NM_020297.5:c.2200G>A rs61688134 rsID:rs61752717 NM_000243.3:c.2080A>G rs61752717 rsID:rs617819 NM_002422.5:c.-376C>G rs617819 rsID:rs619203 NG_033929.1:g.129835C>G rs619203 rsID:rs6313 NM_000621.5:c.102C>T rs6313 rsID:rs646776 NM_001408.3:c.*A>G rs646776 rsID:rs6475606 NC_000009.12:g.22081851C>T rs6475606 rsID:rs6588259 NM_001559.3:c.1459+514A>C rs6588259 rsID:rs659366 NM_003355.3:c.-866G>A rs659366 rsID:rs662 NM_000446.7:c.575A>G rs662 rsID:rs662799 NM_001371904.1:c.-1131T>C rs662799 rsID:rs6685323 NM_080429.3:c.367C>T rs6685323 rsID:rs671 NM_000690.4:c.1510G>A rs671 rsID:rs6748040 NG_011690.1:g.2043G>A rs6748040 rsID:rs676210 NC_000002.12:g.21008652G>A rs676210 rsID:rs6809699 NM_022788.5:c.36T>G rs6809699 rsID:rs6811520 NM_004898.4:c.1450-143A>G rs6811520 rsID:rs6922269 NM_001242767.2:c.1260-4955G>A rs6922269 rsID:rs6929846 NC_000006.12:g.26458037T>C rs6929846 rsID:rs693 Probing XbaI digests with pB23 showed three hybridizing fragments of 8.6, 5.0, and 4.4 kb (designated as X1, X2, and X3, respectively).[PMID:3024002] NM_000384.3:c.7545C>T rs693 rsID:rs698 NM_000669.5:c.1048A>G rs698 rsID:rs699 NM_001384479.1:c.704T>C rs699 rsID:rs699947 NM_003376.6:c.-2578A>C rs699947 rsID:rs7027989 NG_032650.1:g.20120A>G rs7027989 rsID:rs705379 NM_000446.7:c.-108C>T rs705379 rsID:rs7069102 NM_012238.5:c.943-3428C>G rs7069102 rsID:rs708272 NM_000078.3:c.118+279G>A rs708272 rsID:rs7138803 NC_000012.12:g.49853685G>A rs7138803 rsID:rs7242 NM_000602.5:c.*722T>G rs7242 rsID:rs72563731 NM_004797.4:c.323C>T rs72563731 rsID:rs7260160 NM_001972.4:c.-761G>A rs7260160 rsID:rs726344 NM_153756.3:c.499+250C>T rs726344 rsID:rs7291467 NM_006498.3:c.6+3279C>T rs7291467 rsID:rs7294 NM_024006.6:c.*134G>A rs7294 rsID:rs73184536 NM_016179.4:c.2869A>G rs73184536 rsID:rs7319926 NM_016179.4:c.898-13958T>C rs7319926 rsID:rs7412 NM_000041.4:c.526C>T rs7412 rsID:rs7447815 NM_182632.3:c.957C>G rs7447815 rsID:rs7493 NM_000305.3:c.932C>G rs7493 rsID:rs7501477 NM_003255.5:c.-4804T>G rs7501477 rsID:rs7518045 NM_003326.5:c.154-5804T>C rs7518045 rsID:rs762551 NM_000761.5:c.-9-154C>A rs762551 rsID:rs7649970 NM_005037.7:c.-689C>T rs7649970 rsID:rs767880620 NM_000789.4:c.2189C>A rs767880620 rsID:rs76863441 NM_005084.4:c.835G>T rs76863441 rsID:rs776746 NM_000777.5:c.219-237A>G rs776746 rsID:rs7779562 NM_000927.5:c.3085-72C>T rs7779562 rsID:rs7799039 NM_000230.3:c.-2548G>A rs7799039 rsID:rs7832767 NC_000008.11:g.41302340C>T rs7832767 rsID:rs7857345 NC_000009.12:g.22087474T>C rs7857345 rsID:rs7865618 NC_000009.12:g.22031006G>A rs7865618 rsID:rs7905784 NM_182751.3:c.1621A>T rs7905784 rsID:rs7968585 NC_000012.12:g.47838310C>T rs7968585 rsID:rs805304 NM_001303007.2:c.-1151A>C rs805304 rsID:rs8089 NM_003247.5:c.*191T>G rs8089 rsID:rs8123 NM_001386809.1:c.*A>C rs8123 rsID:rs815343 NC_000001.11:g.190186503C>T rs815343 rsID:rs8191992 NM_001006630.2:c.*295T>A rs8191992 rsID:rs833061 NM_003376.6:c.-460C>T rs833061 rsID:rs854560 NM_000446.7:c.163T>A rs854560 rsID:rs867186 NG_032899.2:g.9781A>G rs867186 rsID:rs890293 NG_007931.1:g.4930G>T rs890293 rsID:rs892145 NM_052890.4:c.809T>A rs892145 rsID:rs893454259 NC_000019.10:g.38899853C>T rs893454259 rsID:rs895819 NR_029501.1:n.40A>G rs895819 rsID:rs909253 NM_000595.4:c.-10+90A>G rs909253 rsID:rs9267551 NC_000006.12:g.31730180C>G rs9267551 rsID:rs9319428 NC_000013.11:g.28399484G>A rs9319428 rsID:rs9340799 NM_000125.4:c.453-351A>G rs9340799 rsID:rs9346818 NC_000006.12:g.160493428A>G rs9346818 rsID:rs934945 NM_022817.3:c.3731G>A rs934945 rsID:rs9369640 NM_030948.6:c.250+151419C>A rs9369640 rsID:rs938043469 NM_002203.4:c.672T>C rs938043469 rsID:rs942576 NG_046344.1:g.106140A>C rs942576 rsID:rs948847 NC_000011.10:g.57236870G>T rs948847 rsID:rs9551963 NG_011963.2:g.49933A>C rs9551963 rsID:rs9574 NG_032899.2:g.9859C>G rs9574 rsID:rs9608515 NG_016621.2:g.4137T>C rs9608515 rsID:rs9632884 NC_000009.12:g.22072302G>C rs9632884 rsID:rs964184 NM_003904.5:c.*724C>G rs964184 rsID:rs966221 NG_027957.2:g.322637T>C rs966221 rsID:rs974453 NM_017435.5:c.1383-99A>G rs974453 rsID:rs9925481 NG_016757.1:g.64135C>T rs9925481 rsID:rs9939609 NG_012969.1:g.87653T>A rs9939609 rsID:rs9978223 NG_007570.2:g.18060G>A rs9978223 FGB_BclI NG_012027.1:g.4959G>A NM_000460.4:c.5713A>G NM_002061.4:c.-588C>T NM_004895.5:c.14229A>T NM_004895.5:c.14240C>T NM_004895.5:c.14261A>C NM_004895.5:c.14347A>G NM_005084.4:c.28400C>G NP_000952.1:p.Glu461Ala NP_001052.3:p.Pro1770Leu m.16356T>C m.72T>C m.73A>G NG_007373.1:g.4100A>G NG_007373.1:g.4194G>A NG_007373.1:g.4260T>C NG_007373.1:g.4367C>A NG_007373.1:g.4581A>G NG_007373.1:g.5004G>T NM_000460.4:c.4830C>A NM_000361.3:c.142G>A rsID:rs1800468 NM_030578.4:c.*18G>A rs1800468 NM_022788.5:c.-15+742C>T NG_016444.1:g.4978C>G NM_002203.4:c.873G>A NM_001562.4:c.-137G>C NM_052872.4:c.482A>G NM_000173.7:c.-5T>C NM_000130.5:c.6755A>G NM_000498.3:-344T>C NG_013007.1:g.8016C>G NC_000001.11:g.159712443C>T NM_001872.5:c.-438G>A 9 bp insertion/deletion polymorphism of the BDKRB2 gene rs5810761 APOB PvuII chrY HindIII LPA PN NM_000064.4:c.364C>G NM_000460.4:c.5709A>G NM_000527.5:c. NM_000906.4:1024G>C NM_000930.5:c.-7351C>T NM_001001547.3:c.158C>A NM_001308093.3:c.-333G>C NM_001308093.3:c.-427C>T NM_001308093.3:c.9C>T NM_003455.4:c.461C>T NM_005036.6:c.1047+2528C>G NM_005141.5:c.17382G>T NM_016818.3:c.1889C>T NM_016818.3:c.-311T>A NM_174936.4:c.94G>A NP_000518.1:p. NR_003491.3:c.11093G>A NR_003491.3:c.11741G>A NR_003491.3:c.12311C>T NR_003491.3:c.8813G>A miRBase:MIMAT0000063 hsa-let-7b-5p hsa-let-7b hsa-let-7b-5p let-7b let-7b-5p miRBase:MIMAT0000065 hsa-let-7d-5p hsa-let-7d hsa-let-7d-5p let-7d let-7d-5p miRBase:MIMAT0000414 hsa-let-7g-5p hsa-let-7g hsa-let-7g-5p let-7g let-7g-5p miRBase:MIMAT0000415 hsa-let-7i-5p hsa-let-7i hsa-let-7i-5p let-7i let-7i-5p miRBase:MIMAT0000099 hsa-miR-101-3p hsa-miR-101 hsa-miR-101-3p miR-101 miR-101-3p miRNA-101 miRNA-101-3p microRNA-101 microRNA-101-3p miRBase:MIMAT0000101 hsa-miR-103a-3p hsa-miR-103 hsa-miR-103a hsa-miR-103a-3p miR-103 miR-103a miR-103a-3p miRNA-103 miRNA-103a miRNA-103a-3p microRNA-103 microRNA-103a microRNA-103a-3p miRBase:MIMAT0000103 hsa-miR-106a-5p hsa-miR-106a hsa-miR-106a-5p miR-106a miR-106a-5p miRNA-106a miRNA-106a-5p microRNA-106a microRNA-106a-5p miRBase:MIMAT0000421 hsa-miR-122-5p hsa-miR-122 hsa-miR-122-5p hsa-miR-122a miR-122 miR-122-5p miR-122a miRNA-122 miRNA-122-5p miRNA-122a microRNA-122 microRNA-122-5p microRNA-122a miRBase:MIMAT0005582 hsa-miR-1228-5p hsa-miR-1228* hsa-miR-1228-5p miR-1228* miR-1228-5p miRNA-1228* miRNA-1228-5p microRNA-1228* microRNA-1228-5p NCIT:C106407 miRBase:MIMAT0000422 A 20 ribonucleotide sequence that is a final product of the processing of either MIR124-1 pre-miRNA, MIR124-2 pre-miRNA or MIR124-3 pre-miRNA. This oligonucleotide may be involved in the negative regulation of gene expression. [http://purl.obolibrary.org/obo/NCIT_C106407] hsa-miR-124-3p hsa-miR-124 hsa-miR-124-3p hsa-miR-124a miR-124 miR-124-3p miR-124a miRNA-124 miRNA-124-3p miRNA-124a microRNA 124 microRNA-124 microRNA-124-3p microRNA-124a miRBase:MIMAT0005905 hsa-miR-1254 hsa-miR-1254 miR-1254 miRNA-1254 microRNA-1254 miRBase:MIMAT0000443 hsa-miR-125a-5p hsa-miR-125a hsa-miR-125a-5p miR-125a miR-125a-5p miRNA-125a miRNA-125a-5p microRNA-125a microRNA-125a-5p miRBase:MIMAT0000423 hsa-miR-125b-5p hsa-miR-125b hsa-miR-125b-5p miR-125b miR-125b-5p miRNA-125b miRNA-125b-5p microRNA-125b microRNA-125b-5p miRBase:MIMAT0000445 hsa-miR-126-3p hsa-miR-126 hsa-miR-126-3p miR-126 miR-126-3p miRNA-126 miRNA-126-3p microRNA-126 microRNA-126-3p miRBase:MIMAT0000444 hsa-miR-126-5p hsa-miR-126* hsa-miR-126-5p miR-126* miR-126-5p miRNA-126* miRNA-126-5p microRNA-126* microRNA-126-5p miRBase:MIMAT0005881 hsa-miR-1291 hsa-miR-1291 miR-1291 miRNA-1291 microRNA-1291 miRBase:MIMAT0005891 hsa-miR-1303 hsa-miR-1303 miR-1303 miRNA-1303 microRNA-1303 miRBase:MIMAT0000425 hsa-miR-130a-3p hsa-miR-130a hsa-miR-130a-3p miR-130a miR-130a-3p miRNA-130a miRNA-130a-3p microRNA-130a microRNA-130a-3p miRBase:MIMAT0004593 hsa-miR-130a-5p hsa-miR-130a* hsa-miR-130a-5p miR-130a* miR-130a-5p miRNA-130a* miRNA-130a-5p microRNA-130a* microRNA-130a-5p miRBase:MIMAT0000691 hsa-miR-130b-3p hsa-miR-130b hsa-miR-130b-3p miR-130b miR-130b-3p miRNA-130b miRNA-130b-3p microRNA-130b microRNA-130b-3p miRBase:MIMAT0004680 hsa-miR-130b-5p hsa-miR-130b* hsa-miR-130b-5p miR-130b* miR-130b-5p miRNA-130b* miRNA-130b-5p microRNA-130b* microRNA-130b-5p miRBase:MIMAT0004594 hsa-miR-132-5p hsa-miR-132* hsa-miR-132-5p miR-132* miR-132-5p miRNA-132* miRNA-132-5p microRNA-132* microRNA-132-5p miRBase:MIMAT0000427 hsa-miR-133a-3p hsa-miR-133a hsa-miR-133a-3p miR-133a miR-133a-3p miRNA-133a miRNA-133a-3p microRNA-133a microRNA-133a-3p miRBase:MIMAT0026478 hsa-miR-133a-5p hsa-miR-133a-5p miR-133a-5p miRNA-133a-5p microRNA-133a-5p miRBase:MIMAT0000770 hsa-miR-133b hsa-miR-133b miR-133b miRNA-133b microRNA-133b miRBase:MIMAT0026481 hsa-miR-134-3p hsa-miR-134-3p miR-134-3p miRNA-134-3p microRNA-134-3p miRBase:MIMAT0000447 hsa-miR-134-5p hsa-miR-134 hsa-miR-134-5p miR-134 miR-134-5p miRNA-134 miRNA-134-5p microRNA-134 microRNA-134-5p miRBase:MIMAT0004552 hsa-miR-139-3p hsa-miR-139-3p miR-139-3p miRNA-139-3p microRNA-139-3p miRBase:MIMAT0000250 hsa-miR-139-5p hsa-miR-139 hsa-miR-139-5p miR-139 miR-139-5p miRNA-139 miRNA-139-5p microRNA-139 microRNA-139-5p miRBase:MIMAT0000416 hsa-miR-1-3p hsa-miR-1 hsa-miR-1-3p miR-1 miR-1-3p miRNA-1 miRNA-1-3p microRNA-1 microRNA-1-3p miRBase:MIMAT0000434 hsa-miR-142-3p hsa-miR-142-3p miR-142-3p miRNA-142-3p microRNA-142-3p miRBase:MIMAT0000433 hsa-miR-142-5p hsa-miR-142-5p miR-142-5p miRNA-142-5p microRNA-142-5p miRBase:MIMAT0000435 hsa-miR-143-3p hsa-miR-143 hsa-miR-143-3p miR-143 miR-143-3p miRNA-143 miRNA-143-3p microRNA-143 microRNA-143-3p miRBase:MIMAT0000436 hsa-miR-144-3p hsa-miR-144 hsa-miR-144-3p miR-144 miR-144-3p miRNA-144 miRNA-144-3p microRNA-144 microRNA-144-3p miRBase:MIMAT0004601 hsa-miR-145-3p hsa-miR-145* hsa-miR-145-3p miR-145* miR-145-3p miRNA-145* miRNA-145-3p microRNA-145* microRNA-145-3p miRBase:MIMAT0000437 hsa-miR-145-5p hsa-miR-145 hsa-miR-145-5p miR-145 miR-145-5p miRNA-145 miRNA-145-5p microRNA-145 microRNA-145-5p miRBase:MIMAT0000449 hsa-miR-146a-5p hsa-miR-146 hsa-miR-146a hsa-miR-146a-5p miR-146 miR-146a miR-146a-5p miRNA-146 miRNA-146a miRNA-146a-5p microRNA-146 microRNA-146a microRNA-146a-5p miRBase:MIMAT0000759 hsa-miR-148b-3p hsa-miR-148b hsa-miR-148b-3p miR-148b miR-148b-3p miRNA-148b miRNA-148b-3p microRNA-148b microRNA-148b-3p miRBase:MIMAT0004610 hsa-miR-150-3p hsa-miR-150* hsa-miR-150-3p miR-150* miR-150-3p miRNA-150* miRNA-150-3p microRNA-150* microRNA-150-3p miRBase:MIMAT0000451 hsa-miR-150-5p hsa-miR-150 hsa-miR-150-5p miR-150 miR-150-5p miRNA-150 miRNA-150-5p microRNA-150 microRNA-150-5p miRBase:MIMAT0000757 hsa-miR-151a-3p hsa-miR-151 hsa-miR-151-3p hsa-miR-151a-3p miR-151 miR-151-3p miR-151a-3p miRNA-151 miRNA-151-3p miRNA-151a-3p microRNA-151 microRNA-151-3p microRNA-151a-3p miRBase:MIMAT0004697 hsa-miR-151a-5p hsa-miR-151-5p hsa-miR-151a-5p miR-151-5p miR-151a-5p miRNA-151-5p miRNA-151a-5p microRNA-151-5p microRNA-151a-5p miRBase:MIMAT0000646 hsa-miR-155-5p hsa-miR-155 hsa-miR-155-5p miR-155 miR-155-5p miRNA-155 miRNA-155-5p microRNA-155 microRNA-155-5p miRBase:MIMAT0000068 hsa-miR-15a-5p hsa-miR-15a hsa-miR-15a-5p miR-15a miR-15a-5p miRNA-15a miRNA-15a-5p microRNA-15a microRNA-15a-5p miRBase:MIMAT0000069 hsa-miR-16-5p hsa-miR-16 hsa-miR-16-5p miR-16 miR-16-5p miRNA-16 miRNA-16-5p microRNA-16 microRNA-16-5p miRBase:MIMAT0000070 hsa-miR-17-5p hsa-miR-17 hsa-miR-17-5p miR-17 miR-17-5p miRNA-17 miRNA-17-5p microRNA-17 microRNA-17-5p NCIT:C178568 miRBase:MIMAT0000256 A 23 ribonucleotide sequence that is a final product of the processing of either MIR181A1 pre-miRNA or MIR181A2 pre-miRNA. This oligonucleotide may be involved in the negative regulation of gene expression. [url:http://purl.obolibrary.org/obo/NCIT_C178568] hsa-miR-181a-5p hsa-miR-181a hsa-miR-181a-5p miR-181a miR-181a-5p miRNA-181a miRNA-181a-5p microRNA 181a microRNA-181a microRNA-181a-5p miRBase:MIMAT0000261 hsa-miR-183-5p hsa-miR-183 hsa-miR-183-5p miR-183 miR-183-5p miRNA-183 miRNA-183-5p microRNA-183 microRNA-183-5p miRBase:MIMAT0000454 hsa-miR-184 hsa-miR-184 miR-184 miRNA-184 microRNA-184 miRBase:MIMAT0000455 hsa-miR-185-5p hsa-miR-185 hsa-miR-185-5p miR-185 miR-185-5p miRNA-185 miRNA-185-5p microRNA-185 microRNA-185-5p miRBase:MIMAT0000456 hsa-miR-186-5p hsa-miR-186 hsa-miR-186-5p miR-186 miR-186-5p miRNA-186 miRNA-186-5p microRNA-186 microRNA-186-5p miRBase:MIMAT0000072 hsa-miR-18a-5p hsa-miR-18 hsa-miR-18a hsa-miR-18a-5p miR-18 miR-18a miR-18a-5p miRNA-18 miRNA-18a miRNA-18a-5p microRNA-18 microRNA-18a microRNA-18a-5p miRBase:MIMAT0007882 hsa-miR-1909-5p hsa-miR-1909* hsa-miR-1909-5p miR-1909* miR-1909-5p miRNA-1909* miRNA-1909-5p microRNA-1909* microRNA-1909-5p miRBase:MIMAT0007892 hsa-miR-1915-3p hsa-miR-1915 hsa-miR-1915-3p miR-1915 miR-1915-3p miRNA-1915 miRNA-1915-3p microRNA-1915 microRNA-1915-3p miRBase:MIMAT0000440 hsa-miR-191-5p hsa-miR-191 hsa-miR-191-5p miR-191 miR-191-5p miRNA-191 miRNA-191-5p microRNA-191 microRNA-191-5p miRBase:MIMAT0000222 hsa-miR-192-5p hsa-miR-192 hsa-miR-192-5p miR-192 miR-192-5p miRNA-192 miRNA-192-5p microRNA-192 microRNA-192-5p miRBase:MIMAT0000460 hsa-miR-194-5p hsa-miR-194 hsa-miR-194-5p miR-194 miR-194-5p miRNA-194 miRNA-194-5p microRNA-194 microRNA-194-5p miRBase:MIMAT0000461 hsa-miR-195-5p hsa-miR-195 hsa-miR-195-5p miR-195 miR-195-5p miRNA-195 miRNA-195-5p microRNA-195 microRNA-195-5p miRBase:MIMAT0000227 hsa-miR-197-3p hsa-miR-197 hsa-miR-197-3p miR-197 miR-197-3p miRNA-197 miRNA-197-3p microRNA-197 microRNA-197-3p miRBase:MIMAT0000232 hsa-miR-199a-3p hsa-miR-199a* hsa-miR-199a-3p miR-199a* miR-199a-3p miRNA-199a* miRNA-199a-3p microRNA-199a* microRNA-199a-3p miRBase:MIMAT0000231 hsa-miR-199a-5p hsa-miR-199a hsa-miR-199a-5p miR-199a miR-199a-5p miRNA-199a miRNA-199a-5p microRNA-199a microRNA-199a-5p miRBase:MIMAT0000073 hsa-miR-19a-3p hsa-miR-19a hsa-miR-19a-3p miR-19a miR-19a-3p miRNA-19a miRNA-19a-3p microRNA-19a microRNA-19a-3p miRBase:MIMAT0000074 hsa-miR-19b-3p hsa-miR-19b hsa-miR-19b-3p miR-19b miR-19b-3p miRNA-19b miRNA-19b-3p microRNA-19b microRNA-19b-3p miRBase:MIMAT0000265 hsa-miR-204-5p hsa-miR-204 hsa-miR-204-5p miR-204 miR-204-5p miRNA-204 miRNA-204-5p microRNA-204 microRNA-204-5p miRBase:MIMAT0000241 hsa-miR-208a-3p hsa-miR-208 hsa-miR-208a hsa-miR-208a-3p miR-208 miR-208a miR-208a-3p miRNA-208 miRNA-208a miRNA-208a-3p microRNA-208 microRNA-208a microRNA-208a-3p miRBase:MIMAT0004960 hsa-miR-208b-3p hsa-miR-208b hsa-miR-208b-3p miR-208b miR-208b-3p miRNA-208b miRNA-208b-3p microRNA-208b microRNA-208b-3p miRBase:MIMAT0026722 hsa-miR-208b-5p hsa-miR-208b-5p miR-208b-5p miRNA-208b-5p microRNA-208b-5p miRBase:MIMAT0000267 hsa-miR-210-3p hsa-miR-210 hsa-miR-210-3p miR-210 miR-210-3p miRNA-210 miRNA-210-3p microRNA-210 microRNA-210-3p miRBase:MIMAT0026475 hsa-miR-210-5p hsa-miR-210-5p miR-210-5p miRNA-210-5p microRNA-210-5p miRBase:MIMAT0000271 hsa-miR-214-3p hsa-miR-214 hsa-miR-214-3p miR-214 miR-214-3p miRNA-214 miRNA-214-3p microRNA-214 microRNA-214-3p miRBase:MIMAT0000076 hsa-miR-21-5p hsa-miR-21 hsa-miR-21-5p miR-21 miR-21-5p miRNA-21 miRNA-21-5p microRNA-21 microRNA-21-5p miRBase:MIMAT0000278 hsa-miR-221-3p hsa-miR-221 hsa-miR-221-3p miR-221 miR-221-3p miRNA-221 miRNA-221-3p microRNA-221 microRNA-221-3p miRBase:MIMAT0000280 hsa-miR-223-3p hsa-miR-223 hsa-miR-223-3p miR-223 miR-223-3p miRNA-223 miRNA-223-3p microRNA-223 microRNA-223-3p miRBase:MIMAT0000077 hsa-miR-22-3p hsa-miR-22 hsa-miR-22-3p miR-22 miR-22-3p miRNA-22 miRNA-22-3p microRNA-22 microRNA-22-3p miRBase:MIMAT0009198 hsa-miR-224-3p hsa-miR-224* hsa-miR-224-3p miR-224* miR-224-3p miRNA-224* miRNA-224-3p microRNA-224* microRNA-224-3p miRBase:MIMAT0004495 hsa-miR-22-5p hsa-miR-22* hsa-miR-22-5p miR-22* miR-22-5p miRNA-22* miRNA-22-5p microRNA-22* microRNA-22-5p miRBase:MIMAT0000078 hsa-miR-23a-3p hsa-miR-23a hsa-miR-23a-3p miR-23a miR-23a-3p miRNA-23a miRNA-23a-3p microRNA-23a microRNA-23a-3p miRBase:MIMAT0000418 hsa-miR-23b-3p hsa-miR-23b hsa-miR-23b-3p miR-23b miR-23b-3p miRNA-23b miRNA-23b-3p microRNA-23b microRNA-23b-3p miRBase:MIMAT0000079 hsa-miR-24-1-5p hsa-miR-189 hsa-miR-24-1* hsa-miR-24-1-5p miR-189 miR-24-1* miR-24-1-5p miRNA-189 miRNA-24-1* miRNA-24-1-5p microRNA-189 microRNA-24-1* microRNA-24-1-5p miRBase:MIMAT0000080 hsa-miR-24-3p hsa-miR-24 hsa-miR-24-3p miR-24 miR-24-3p miRNA-24 miRNA-24-3p microRNA-24 microRNA-24-3p miRBase:MIMAT0004499 hsa-miR-26a-1-3p hsa-miR-26a-1* hsa-miR-26a-1-3p miR-26a-1* miR-26a-1-3p miRNA-26a-1* miRNA-26a-1-3p microRNA-26a-1* microRNA-26a-1-3p miRBase:MIMAT0000082 hsa-miR-26a-5p hsa-miR-26a hsa-miR-26a-5p miR-26a miR-26a-5p miRNA-26a miRNA-26a-5p microRNA-26a microRNA-26a-5p miRBase:MIMAT0000083 hsa-miR-26b-5p hsa-miR-26b hsa-miR-26b-5p miR-26b miR-26b-5p miRNA-26b miRNA-26b-5p microRNA-26b microRNA-26b-5p miRBase:MIMAT0000084 hsa-miR-27a-3p hsa-miR-27a hsa-miR-27a-3p miR-27a miR-27a-3p miRNA-27a miRNA-27a-3p microRNA-27a microRNA-27a-3p miRBase:MIMAT0000086 hsa-miR-29a-3p hsa-miR-29a hsa-miR-29a-3p miR-29a miR-29a-3p miRNA-29a miRNA-29a-3p microRNA-29a microRNA-29a-3p miRBase:MIMAT0000100 hsa-miR-29b-3p hsa-miR-29b hsa-miR-29b-3p miR-29b miR-29b-3p miRNA-29b miRNA-29b-3p microRNA-29b microRNA-29b-3p miRBase:MIMAT0000681 hsa-miR-29c-3p hsa-miR-29c hsa-miR-29c-3p miR-29c miR-29c-3p miRNA-29c miRNA-29c-3p microRNA-29c microRNA-29c-3p miRBase:MIMAT0000714 hsa-miR-302b-5p hsa-miR-302b* hsa-miR-302b-5p miR-302b* miR-302b-5p miRNA-302b* miRNA-302b-5p microRNA-302b* microRNA-302b-5p miRBase:MIMAT0000087 hsa-miR-30a-5p hsa-miR-30a hsa-miR-30a-5p miR-30a miR-30a-5p miRNA-30a miRNA-30a-5p microRNA-30a microRNA-30a-5p miRBase:MIMAT0000245 hsa-miR-30d-5p hsa-miR-30d hsa-miR-30d-5p miR-30d miR-30d-5p miRNA-30d miRNA-30d-5p microRNA-30d microRNA-30d-5p miRBase:MIMAT0000692 hsa-miR-30e-5p hsa-miR-30e hsa-miR-30e-5p miR-30e miR-30e-5p miRNA-30e miRNA-30e-5p microRNA-30e microRNA-30e-5p miRBase:MIMAT0000510 hsa-miR-320a-3p hsa-miR-320 hsa-miR-320a hsa-miR-320a-3p miR-320 miR-320a miR-320a-3p miRNA-320 miRNA-320a miRNA-320a-3p microRNA-320 microRNA-320a microRNA-320a-3p miRBase:MIMAT0005792 hsa-miR-320b hsa-miR-320b miR-320b miRNA-320b microRNA-320b miRBase:MIMAT0000762 hsa-miR-324-3p hsa-miR-324-3p miR-324-3p miRNA-324-3p microRNA-324-3p miRBase:MIMAT0000090 hsa-miR-32-5p hsa-miR-32 hsa-miR-32-5p miR-32 miR-32-5p miRNA-32 miRNA-32-5p microRNA-32 microRNA-32-5p miRBase:MIMAT0000752 hsa-miR-328-3p hsa-miR-328 hsa-miR-328-3p miR-328 miR-328-3p miRNA-328 miRNA-328-3p microRNA-328 microRNA-328-3p miRBase:MIMAT0026486 hsa-miR-328-5p hsa-miR-328-5p miR-328-5p miRNA-328-5p microRNA-328-5p miRBase:MIMAT0000751 hsa-miR-330-3p hsa-miR-330 hsa-miR-330-3p miR-330 miR-330-3p miRNA-330 miRNA-330-3p microRNA-330 microRNA-330-3p miRBase:MIMAT0000760 hsa-miR-331-3p hsa-miR-331 hsa-miR-331-3p miR-331 miR-331-3p miRNA-331 miRNA-331-3p microRNA-331 microRNA-331-3p miRBase:MIMAT0000091 hsa-miR-33a-5p hsa-miR-33 hsa-miR-33a hsa-miR-33a-5p miR-33 miR-33a miR-33a-5p miRNA-33 miRNA-33a miRNA-33a-5p microRNA-33 microRNA-33a microRNA-33a-5p miRBase:MIMAT0003301 hsa-miR-33b-5p hsa-miR-33b hsa-miR-33b-5p miR-33b miR-33b-5p miRNA-33b miRNA-33b-5p microRNA-33b microRNA-33b-5p miRBase:MIMAT0000750 hsa-miR-340-3p hsa-miR-340 hsa-miR-340* hsa-miR-340-3p miR-340 miR-340* miR-340-3p miRNA-340 miRNA-340* miRNA-340-3p microRNA-340 microRNA-340* microRNA-340-3p miRBase:MIMAT0000255 hsa-miR-34a-5p hsa-miR-34a hsa-miR-34a-5p miR-34a miR-34a-5p miRNA-34a miRNA-34a-5p microRNA-34a microRNA-34a-5p miRBase:MIMAT0000703 hsa-miR-361-5p hsa-miR-361 hsa-miR-361-5p miR-361 miR-361-5p miRNA-361 miRNA-361-5p microRNA-361 microRNA-361-5p miRBase:MIMAT0018076 hsa-miR-3656 hsa-miR-3656 miR-3656 miRNA-3656 microRNA-3656 miRBase:MIMAT0000728 hsa-miR-375-3p hsa-miR-375 hsa-miR-375-3p miR-375 miR-375-3p miRNA-375 miRNA-375-3p microRNA-375 microRNA-375-3p miRBase:MIMAT0037313 hsa-miR-375-5p hsa-miR-375-5p miR-375-5p miRNA-375-5p microRNA-375-5p miRBase:MIMAT0000732 hsa-miR-378a-3p hsa-miR-378 hsa-miR-378a-3p hsa-miR-422b miR-378 miR-378a-3p miR-422b miRNA-378 miRNA-378a-3p miRNA-422b microRNA-378 microRNA-378a-3p microRNA-422b miRBase:MIMAT0000733 hsa-miR-379-5p hsa-miR-379 hsa-miR-379-5p miR-379 miR-379-5p miRNA-379 miRNA-379-5p microRNA-379 microRNA-379-5p miRBase:MIMAT0000734 hsa-miR-380-5p hsa-miR-380* hsa-miR-380-5p miR-380* miR-380-5p miRNA-380* miRNA-380-5p microRNA-380* microRNA-380-5p miRBase:MIMAT0004748 hsa-miR-423-5p hsa-miR-423-5p miR-423-5p miRNA-423-5p microRNA-423-5p miRBase:MIMAT0001341 hsa-miR-424-5p hsa-miR-424 hsa-miR-424-5p miR-424 miR-424-5p miRNA-424 miRNA-424-5p microRNA-424 microRNA-424-5p miRBase:MIMAT0019006 hsa-miR-4478 hsa-miR-4478 miR-4478 miRNA-4478 microRNA-4478 miRBase:MIMAT0019044 hsa-miR-4507 hsa-miR-4507 miR-4507 miRNA-4507 microRNA-4507 miRBase:MIMAT0004784 hsa-miR-455-3p hsa-miR-455-3p miR-455-3p miRNA-455-3p microRNA-455-3p miRBase:MIMAT0002173 hsa-miR-483-3p hsa-miR-483 hsa-miR-483-3p miR-483 miR-483-3p miRNA-483 miRNA-483-3p microRNA-483 microRNA-483-3p miRBase:MIMAT0004761 hsa-miR-483-5p hsa-miR-483-5p miR-483-5p miRNA-483-5p microRNA-483-5p miRBase:MIMAT0004762 hsa-miR-486-3p hsa-miR-486-3p miR-486-3p miRNA-486-3p microRNA-486-3p miRBase:MIMAT0002177 hsa-miR-486-5p hsa-miR-486 hsa-miR-486-5p miR-486 miR-486-5p miRNA-486 miRNA-486-5p microRNA-486 microRNA-486-5p miRBase:MIMAT0002812 hsa-miR-492 hsa-miR-492 miR-492 miRNA-492 microRNA-492 miRBase:MIMAT0002816 hsa-miR-494-3p hsa-miR-494 hsa-miR-494-3p miR-494 miR-494-3p miRNA-494 miRNA-494-3p microRNA-494 microRNA-494-3p miRBase:MIMAT0026607 hsa-miR-494-5p hsa-miR-494-5p miR-494-5p miRNA-494-5p microRNA-494-5p miRBase:MIMAT0002820 hsa-miR-497-5p hsa-miR-497 hsa-miR-497-5p miR-497 miR-497-5p miRNA-497 miRNA-497-5p microRNA-497 microRNA-497-5p miRBase:MIMAT0002870 hsa-miR-499a-5p hsa-miR-499 hsa-miR-499-5p hsa-miR-499a-5p miR-499 miR-499-5p miR-499a-5p miRNA-499 miRNA-499-5p miRNA-499a-5p microRNA-499 microRNA-499-5p microRNA-499a-5p miRBase:MIMAT0002828 hsa-miR-519e-5p hsa-miR-519e* hsa-miR-519e-5p miR-519e* miR-519e-5p miRNA-519e* miRNA-519e-5p microRNA-519e* microRNA-519e-5p miRBase:MIMAT0003165 hsa-miR-545-3p hsa-miR-545 hsa-miR-545-3p miR-545 miR-545-3p miRNA-545 miRNA-545-3p microRNA-545 microRNA-545-3p miRBase:MIMAT0003266 hsa-miR-598-3p hsa-miR-598 hsa-miR-598-3p miR-598 miR-598-3p miRNA-598 miRNA-598-3p microRNA-598 microRNA-598-3p miRBase:MIMAT0026620 hsa-miR-598-5p hsa-miR-598-5p miR-598-5p miRNA-598-5p microRNA-598-5p miRBase:MIMAT0003283 hsa-miR-615-3p hsa-miR-615 hsa-miR-615-3p miR-615 miR-615-3p miRNA-615 miRNA-615-3p microRNA-615 microRNA-615-3p miRBase:MIMAT0003306 hsa-miR-636 hsa-miR-636 miR-636 miRNA-636 microRNA-636 miRBase:MIMAT0003318 hsa-miR-648 hsa-miR-648 miR-648 miRNA-648 microRNA-648 miRBase:MIMAT0003338 hsa-miR-660-5p hsa-miR-660 hsa-miR-660-5p miR-660 miR-660-5p miRNA-660 miRNA-660-5p microRNA-660 microRNA-660-5p miRBase:MIMAT0005867 hsa-miR-663b hsa-miR-663b miR-663b miRNA-663b microRNA-663b miRBase:MIMAT0027510 hsa-miR-6805-5p hsa-miR-6805-5p miR-6805-5p miRNA-6805-5p microRNA-6805-5p miRBase:MIMAT0004553 hsa-miR-7-1-3p hsa-miR-7-1* hsa-miR-7-1-3p miR-7-1* miR-7-1-3p miRNA-7-1* miRNA-7-1-3p microRNA-7-1* microRNA-7-1-3p miRBase:MIMAT0004946 hsa-miR-744-3p hsa-miR-744* hsa-miR-744-3p miR-744* miR-744-3p miRNA-744* miRNA-744-3p microRNA-744* microRNA-744-3p miRBase:MIMAT0004911 hsa-miR-874-3p hsa-miR-874 hsa-miR-874-3p miR-874 miR-874-3p miRNA-874 miRNA-874-3p microRNA-874 microRNA-874-3p miRBase:MIMAT0000092 hsa-miR-92a-3p hsa-miR-92 hsa-miR-92a hsa-miR-92a-3p miR-92 miR-92a miR-92a-3p miRNA-92 miRNA-92a miRNA-92a-3p microRNA-92 microRNA-92a microRNA-92a-3p miRBase:MIMAT0000093 hsa-miR-93-5p hsa-miR-93 hsa-miR-93-5p miR-93 miR-93-5p miRNA-93 miRNA-93-5p microRNA-93 microRNA-93-5p miRBase:MIMAT0004982 hsa-miR-939-5p hsa-miR-939 hsa-miR-939-5p miR-939 miR-939-5p miRNA-939 miRNA-939-5p microRNA-939 microRNA-939-5p miRBase:MIMAT0004984 hsa-miR-941 hsa-miR-941 miR-941 miRNA-941 microRNA-941 miRBase:MIMAT0000097 hsa-miR-99a-5p hsa-miR-99a hsa-miR-99a-5p miR-99a miR-99a-5p miRNA-99a miRNA-99a-5p microRNA-99a microRNA-99a-5p HGNC:73 ATP binding cassette subfamily G member 1 ABCG1 ABC8 HGNC:3569 acyl-CoA synthetase long chain family member 1 ACSL1 ACS1 FACL1 LACS LACS1 LACS2 HGNC:171 activin A receptor type 1 ACVR1 ACVR1A ALK2 SKR1 HGNC:195 ADAM metallopeptidase domain 17 ADAM17 CD156B cSVP HGNC:43877 BRAF-activated non-protein coding RNA BANCR LINC00586 HGNC:1131 BTG anti-proliferation factor 2 BTG2 APRO1 MGC126063 MGC126064 PC3 TIS21 HGNC:1338 complement C5a receptor 1 C5AR1 C5A C5AR CD88 HGNC:4527 complement component 5a receptor 2 C5AR2 C5L2 HGNC:55342 CAMTA2 antisense RNA 1 CAMTA2-AS1 HGNC:1786 cyclin dependent kinase inhibitor 1C CDKN1C KIP2 P57 HGNC:1788 cyclin dependent kinase inhibitor 2B CDKN2B CDK4I INK4B MTS2 P15 TP15 p15INK4b HGNC:34341 CDKN2B antisense RNA 1 CDKN2B-AS1 ANRIL CDKN2B-AS NCRNA00089 PCAT12 RP11-145E5.4 p15AS HGNC:48926 CDR1 antisense RNA CDR1-AS CDR1NAT CDR1as ciRS-7 HGNC:11869 cell migration inducing hyaluronidase 2 CEMIP2 HGNC:53620 cardiac hypertrophy associated epigenetic regulator 1 CHAER1 Chaer HGNC:14555 C-type lectin domain family 4 member E CLEC4E mincle HGNC:2316 copine 3 CPNE3 ENSG00000230606 APPAT ENST00000620272 HGNC:3541 coagulation factor III, tissue factor F3 CD142 TF HGNC:4501 free fatty acid receptor 2 FFAR2 FFA2R HGNC:3721 FKBP prolyl isomerase 5 FKBP5 FKBP51 FKBP54 P54 PPIase Ptg-10 HGNC:289 G protein-coupled receptor kinase 2 GRK2 BARK1 HGNC:4713 H19 imprinted maternally expressed transcript H19 ASM ASM1 D11S813E LINC00008 MIR675HG NCRNA00008 HGNC:43015 HIF1A antisense RNA 2 HIF1A-AS2 3'aHIF-1A aHIF HGNC:33510 HOX transcript antisense RNA HOTAIR HOXC-AS4 HOXC11-AS1 NCRNA00072 HGNC:5344 intercellular adhesion molecule 1 ICAM1 BB2 CD54 HGNC:15552 interleukin 1 family member 10 IL1F10 FKSG75 IL-1F10 IL-1HY2 IL1-theta MGC11983 MGC119832 MGC119833 HGNC:6018 interleukin 6 IL6 BSF2 HGF HSF IL-6 HGNC:6019 interleukin 6 receptor IL6R CD126 HGNC:6021 interleukin 6 signal transducer IL6ST CD130 GP130 sGP130 HGNC:6295 KCNQ1 opposite strand/antisense transcript 1 KCNQ1OT1 KCNQ1-AS2 KvDMR1 KvLQT1-AS LIT1 NCRNA00012 HGNC:6501 lysosomal associated membrane protein 2 LAMP2 CD107b HGNC:49597 lymphatic endothelial transcriptional regulator lncRNA 1 LETR1 HGNC:6563 galectin 3 LGALS3 GALIG MAC-2 HGNC:26885 long intergenic non-protein coding RNA, p53 induced transcript LINC-PINT FLJ43663 LincRNA-Pint PINT HGNC:6717 latent transforming growth factor beta binding protein 4 LTBP4 FLJ46318 FLJ90018 LTBP-4 LTBP-4L HGNC:29665 metastasis associated lung adenocarcinoma transcript 1 MALAT1 HCN LINC00047 MALAT-1 NCRNA00047 NEAT2 PRO1073 mascRNA HGNC:6838 microtubule associated protein 1 light chain 3 alpha MAP1LC3A ATG8E LC3 LC3A MAP1ALC3 MAP1BLC3 HGNC:51291 myosin heavy chain associated RNA transcript MHRT Myheart HGNC:33425 myocardial infarction associated transcript MIAT FLJ25967 LINC00066 NCRNA00066 Rncr2 gomafu lncRNA-MIAT HGNC:7166 matrix metallopeptidase 2 MMP2 TBE-1 HGNC:7176 matrix metallopeptidase 9 MMP9 HGNC:50279 mitochondrially encoded long non-coding cardiac associated RNA MT-LIPCAR LIPCAR uc022bqs.1 HGNC:30092 nicotinamide phosphoribosyltransferase NAMPT PBEF HGNC:30815 nuclear paraspeckle assembly transcript 1 NEAT1 LINC00084 MENepsilon/beta TncRNA VINC HGNC:25906 nuclear factor of activated T cells 2 interacting protein NFATC2IP ESC2 FLJ14639 NIP45 RAD60 HGNC:7873 nitric oxide synthase 2 NOS2 HEP-NOS NOS iNOS HGNC:7881 notch receptor 1 NOTCH1 HGNC:8537 purinergic receptor P2X 7 P2RX7 MGC20089 P2X7 HGNC:8971 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2A PI3K-C2alpha HGNC:9030 phospholipase A2 group IB PLA2G1B HGNC:26215 phospholipase B domain containing 1 PLBD1 FLJ22662 HGNC:9237 PPARG coactivator 1 alpha PPARGC1A PGC-1alpha PGC1 PGC1A HGNC:10894 protein arginine methyltransferase 5 PRMT5 SKB1Hs HGNC:9605 prostaglandin-endoperoxide synthase 2 PTGS2 COX2 HGNC:9756 quiescin sulfhydryl oxidase 1 QSOX1 HGNC:18260 RAB20, member RAS oncogene family RAB20 FLJ20429 HGNC:10489 S100 calcium binding protein A12 S100A12 CAAF1 CAGC CGRP ENRAGE MRP6 p6 HGNC:10504 S100 calcium binding protein P S100P HGNC:10528 SAM domain, SH3 domain and nuclear localization signals 1 SAMSN1 HACS1 NASH1 SASH2 SH3D6B SLy2 HGNC:49445 SLC16A1 antisense RNA 1 SLC16A1-AS1 ENST00000421157.1 HGNC:11089 sarcolipin SLN MGC12301 MGC125854 MGC125855 HGNC:33098 small nucleolar RNA host gene 8 SNHG8 LINC00060 NCRNA00060 HGNC:19391 suppressor of cytokine signaling 3 SOCS3 CIS3 Cish3 SOCS-3 SSI-3 HGNC:11459 sulfotransferase family 2B member 1 SULT2B1 HSST2 HGNC:18587 Sad1 and UNC84 domain containing 1 SUN1 FLJ12407 KIAA0810 HGNC:11616 transcription elongation factor A like 1 TCEAL1 SIIR WEX9 p21 pp21 HGNC:11772 transforming growth factor beta receptor 1 TGFBR1 ACVRLK4 ALK-5 ALK5 TBR-i TBRI HGNC:11848 toll like receptor 2 TLR2 CD282 TIL4 HGNC:11850 toll like receptor 4 TLR4 ARMD10 CD284 TLR-4 hToll HGNC:11892 tumor necrosis factor TNF DIF TNF-alpha TNFSF2 HGNC:11909 TNF receptor superfamily member 11b TNFRSF11B OCIF TR1 HGNC:26966 TNFRSF14 antisense RNA 1 TNFRSF14-AS1 ENST00000416860.2 HGNC:11976 tenascin XB TNXB TNXBS XB XBS HGNC:18082 transient receptor potential cation channel subfamily V member 2 TRPV2 VRL VRL-1 VRL1 HGNC:28432 tetratricopeptide repeat domain 9C TTC9C MGC29649 HGNC:26066 taurine up-regulated 1 TUG1 FLJ20618 LINC00080 NCRNA00080 HGNC:16952 thioredoxin interacting protein TXNIP ARRDC6 EST01027 HHCPA78 THIF VDUP1 HGNC:37126 urothelial cancer associated 1 UCA1 CUDR LINC00178 UCAT1 onco-lncRNA-36 HGNC:12680 vascular endothelial growth factor A VEGFA VEGF-A VPF HGNC:33101 ZNFX1 antisense RNA 1 ZFAS1 HSUP1 HSUP2 metabolic equivalent of task glycated hemoglobin intermediate density lipoprotein cholesterol procollagen type I N-terminal peptide interleukin-1 receptor-associated kinase 3 collagenase 3 leucine-rich alpha-2-glycoprotein activin receptor type-1 glycogen phosphorylase, brain form very low density lipoprotein triglyceride eicosadienoic acid tyrosine-protein kinase receptor UFO trem-like transcript 1 protein high-density lipoprotein real-time clot formation time bone morphogenetic protein 4 tumor necrosis factor myosin interleukin-8 vascular endothelial growth factor A a disintegrin and metalloproteinase with thrombospondin motifs 3 protein carbonyl heat shock 70 kDa protein 4 thiol C-terminal fragment of agrin platelet endothelial cell adhesion molecule collagen alpha-2(VI) chain macrophage IgG folate profilin-1 interleukin-12 total cholesterol erythrocyte sedimentation rate ATP synthase-coupling factor 6, mitochondrial eosinophil to leukocyte ratio muse cell fibrinolysis albumin to globulin ratio trimethyllysine peroxisome proliferator-activated receptor gamma coactivator 1-alpha phosphoglucomutase amino acid derivative vasopressin-neurophysin 2-copeptin/troponin T, cardiac muscle ratio brain-derived neurotrophic factor thromboelastography maximum amplitude interleukin-1 beta proprotein convertase subtilisin/kexin type 9 cholesteryl ester transfer protein haptoglobin azurocidin Dual specificity protein phosphatase 2 deoxyribonuclease-1 omega-3 fatty acid type V collagen antibody high sensitivity cardiac troponin T fractal dimension NAD-dependent protein deacetylase sirtuin-1 interleukin-13 coagulation factor XIII A chain cyclin-dependent kinase inhibitor 1C total cholesterol to high-density lipoprotein cholesterol ratio lutein magnesium blood glucose nucleosome cerium oxygen consumption uric acid antigen free L-carnitine procollagen type I C-terminal peptide octadecadienoic acid n-6 trans vasopressin-neurophysin 2-copeptin undercarboxylated osteocalcin/total osteocalcin ratio superoxide dismutase [Mn], mitochondrial remnant-like particle cholesterol coagulation factor XIIa prorelaxin H2 omega-3:omega-6 polyunsaturated fatty acid ratio CCN family member 2 docosahexaenoic acid blood group A creatinine clearance anticardiolipin IgM antibody mid-regional pro-atrial natriuretic peptide myosin light chain 3 fractalkine ratio of contrast volume to glomerular filtration rate agrin circulating endothelial cell count myeloperoxidase serum collagen biomarkers creatine kinase MB tripartite motif-containing protein 72 pro-interleukin-16 a disintegrin and metalloproteinase with thrombospondin motifs 13 blood urea nitrogen platelet basic protein metabolite cathelicidin antimicrobial peptide C-X-C chemokine receptor type 4 aspartate aminotransferase to alanine aminotransferase ratio oxygen consumption at ventilation threshold alpha hydroxybutyrate dehydrogenase vitamin K-dependent protein Z glypican-6 C-terminal pro-endothelin-1 60 kDa heat shock protein, mitochondrial fibulin-5 albumin to creatinine protein ratio palmitoleic acid retinoic acid receptor responder protein 2 placenta growth factor thioredoxin toll-like receptor 4 interleukin-27 subunit alpha oxygen extraction ratio suppressor of cytokine signaling 3 beta-enolase disulphide/total thiol ratio gamma-glutamyltransferase perilipin-2 platelet count acute-to-chronic glycemic ratio anion gap blood cell count asymmetric dimethylarginine basigin apolipoprotein B-100 interleukin-18 mean platelet volume to lymphocyte ratio hexadecenoic acid trans antibody to endothelial protein C receptor aldosterone serum paraoxonase/arylesterase 1 histidine-rich glycoprotein zinc lactate dehydrogenase isoenzyme 5 dipeptidyl peptidase 4 sodium-dependent serotonin transporter interleukin beta-2 glycoprotein 1 IgG antibody platelet activation quantitative insulin sensitivity check index blood group AB cytochrome P450 2C19 annexin A5 creatine kinase lipoprotein(a) interleukin-21 thrombin antithrombin complex VIP peptides mercury cytochrome b-245 heavy chain natriuretic peptides B follistatin-related protein 1 thiobarbituric acid reactive substances antibody to platelet factor 4-heparin complex stromal cell-derived factor 1 tetranectin cathepsin S interleukin-7 angiotensin-converting enzyme interleukin-19 carbon dioxide combining power iron C-reactive protein/albumin ratio neutrophil to lymphocyte ratio beta-thromboglobulin catalase anti-angiogenic isoform of vascular endothelial growth factor A to total vascular endothelial growth factor A ratio adiponectin C-C motif chemokine 5 protein S100-A4 hepcidin high mobility group protein B1 arachidonic acid/dihomogammalinolenic acid ratio phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN mannan-binding lectin serine protease 1 endogenous thrombin potential cystathionine intercellular adhesion molecule 1 creatine kinase B-type monoclonal antibody M30 fibrinogen alpha chain fatty acid ferritin signal peptide, CUB and EGF-like domain-containing protein 1 protein MON2 homolog homocysteine thiolactone/creatinine ratio angiotensin-converting enzyme 2 prothrombin time alkaline phosphatase a disintegrin and metalloproteinase with thrombospondin motifs 7 fatty acid-binding protein, adipocyte Klotho tenascin vitamin apolipoprotein A-I urocortin plasma osmolality rho-associated protein kinase 1 cardiotrophin-1 alpha-2-HS-glycoprotein xanthine dehydrogenase/oxidase IgE nuclear factor NF-kappa-B p105 subunit activated partial thromboplastin time free thyroxine erythropoietin platelet-to-lymphocyte ratio prolactin homocysteine epicardial fat C-X-C motif chemokine 16 fasting blood glucose oxygen tension at 50% saturation osteocalcin fibroblast growth factor 21 type III procollagen N-terminal peptide autoantibody low-density lipoprotein cholesterol to total cholesterol ratio 8-hydroxy-2\'-deoxyguanosine apelin-12 tumor necrosis factor receptor superfamily member 11B secreted frizzled-related protein 5 platelet factor 4 glucagon-like peptide 1 C-C chemokine receptor type 1 interleukin-6 receptor subunit alpha neutrophil collagenase 72 kDa type IV collagenase systemic immune-inflammation index low-density lipoprotein fibrinopeptide B-beta 30-43 myc proto-oncogene protein alpha-amylase coagulation factor V NAD-dependent protein deacetylase sirtuin-6 malondialdehyde low density lipoprotein leukocyte count to mean platelet volume ratio endothelial progenitor cell carboxypeptidase B2 docosapentaenoic acid n-6 immunoglobulin osteopontin tumor necrosis factor ligand superfamily member 13B total oxidative status integrin alpha-M endoglin systemic immune-inflammatory index stromelysin-1 insulin-like growth factor-binding protein 4 antithrombin-III cysteinyl-glycine CK-MM3/CK-MM1 isoforms lactate cellular tumor antigen p53 aspartate aminotransferase troponin T, cardiac muscle 1-hydroxypyrene actin, alpha skeletal muscle aldolase leukocyte count high-density lipoprotein cholesterol erythrocyte count plateletcrit platelet-derived growth factor-AA vascular cell adhesion protein 1 interventricular septum fat methionine malondialdehyde type-1 angiotensin II receptor vitamin K-dependent protein S CD133+ progenitor cells blood group O complement C4-A glucagon-like peptide 1 receptor granulocyte-macrophage colony-stimulating factor IgG antibody to oxidized low-density lipoprotein N-terminal prohormone of brain natriuretic peptide insulin-like growth factor-binding protein 3 cholesterol efflux capacity non-enzymatic antioxidant capacity membrane attack complex interleukin-34 complement C3 acylation stimulating protein thromboxane B2 fibrinopeptide B-beta 1-42 syndecan-4 matrix metalloproteinase endogenous thrombin potential lag time blood type myoglobin/carbonic anhydrase 3 ratio granulocyte colony-stimulating factor bone morphogenetic protein 2 mean platelet volume sulfatide copper tumor necrosis factor/interleukin-10 ratio anticardiolipin IgG antibody myosin-binding protein C, cardiac-type D-dimer deoxycytidylate deaminase indocyanine green clearance CD40 ligand oxygen delivery chromogranin-A red blood cell distribution width to platelet ratio eicosapentaenoic acid clot-lysis time high sensitivity cardiac troponin I 5-methoxytryptophan calcium to magnesium ratio nitric oxide synthase, endothelial hepatitis A virus cellular receptor 1 interleukin-2 receptor subunit alpha platelet glycoprotein V alpha-amylase 1A prostate-specific antigen prothrombin glycine growth/differentiation factor 15 tissue plasminogen activator antigen MHC class I polypeptide-related sequence A alkyl-phosphatidylcholine C-C motif chemokine 7 coagulation factor VII angiopoietin-related protein 2 dehydroepiandrosterone sulfate fibrin monomer pro-opiomelanocortin platelet aggregation endogenous heparin very-low-density lipoprotein cholesterol cathepsin D interleukin-1 receptor antagonist protein triglyceride-glucose index apelin receptor activated protein C ultra high sensitivity C-reactive protein clusterin estradiol to testosterone ratio interleukin-1 receptor-like 1 interleukin-10/interleukin-6 ratio endothelial cell-selective adhesion molecule apolipoprotein(a) cytochrome c alpha-1-acid glycoprotein 1 pregnancy zone protein prolyl endopeptidase FAP fatty acid-binding protein, heart hormone coagulation factor VIIa advanced glycosylation end product-specific receptor heparin cofactor 2 tissue-type plasminogen activator hemoglobin a disintegrin and metalloproteinase with thrombospondin motifs 9 leptin myoglobin fetuin-B adipolin macrophage migration inhibitory factor anti-apolipoprotein A-1 IgG peripheral blood mononuclear cell peptide YY phospholipid-transporting ATPase ABCA1 natriuretic peptides A L-lactate dehydrogenase B chain alanine aminotransferase neopterin phosphate complement C5 somatotropin toll-like receptor 1 vitamin K-dependent protein C serine protease HTRA2, mitochondrial serum total protein actin, gamma-enteric smooth muscle inserted peptide sequence GVIMVIAVSCVF type I collagen C-telopeptide albumin excretion rate heparanase 25-hydroxyvitamin D lipoprotein cholesterol tumor necrosis factor receptor superfamily member 10B acetylcholinesterase glutathione hydrolase 1 proenzyme endothelial cell-specific molecule 1 titin immunoglobulin heavy constant mu cystatin-C platelet-derived growth factor subunit A mean platelet volume to platelet count ratio myosin light chain 1/3, skeletal muscle isoform selenium myeloblastin calprotectin thyroid-stimulating hormone IgA stromal cell-derived factor 1 isoform Alpha alpha-2-antiplasmin phospholipase A2, membrane associated lipopolysaccharide-binding protein tumor necrosis factor receptor superfamily member 5 B2 bradykinin receptor high sensitivity cardiac troponin apolipoprotein A-II coagulation factor VII/coagulation factor VII antigen ratio tumor necrosis factor receptor superfamily member 1B stabilin-1 type III procollagen N-terminal peptide/type I collagen C-telopeptide ratio chitinase-3-like protein 1 urokinase-type plasminogen activator interleukin-37 monocyte-platelet aggregates alpha-linolenic acid ischemia-modified albumin lipoprotein lipase stanniocalcin-1 trimethylamine N-oxide toll-like receptor 2 N(6)-carboxymethyllysine low-density lipoprotein cholesterol N-terminal proA-type natriuretic peptide mimecan tissue factor mid-regional pro-adrenomedullin low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio red blood cell distribution width scavenger receptor cysteine-rich type 1 protein M130 non-high density lipoprotein cholesterol glutathione peroxidase 3 polyunsaturated fatty acid insulin-like growth factor-binding protein 1 lactate dehydrogenase calcium vitamin D CD27 antigen IgM antibody to endothelial protein C receptor nitric oxide adropin ABO blood group glutarylglycine monocyte count mucin-16 tumor necrosis factor ligand superfamily member 10 proto-oncogene Wnt-1 beta-cryptoxanthin macrophage colony-stimulating factor 1 glycosaminoglycan IgM sodium/potassium ratio lycopene gastrin double stranded deoxyribonucleic acid triglyceride to high-density lipoprotein cholesterol ratio intelectin-1 fermitin family homolog 3 beta-adrenergic receptor kinase 1 platelet glycoprotein 4 nicotinamide phosphoribosyltransferase P-selectin collagen alpha-1(XVIII) chain protein cardiac troponin tumor necrosis factor ligand superfamily member 11 allergen specific immunoglobulin E lipid cholinesterase presepsin plasminogen activator inhibitor 1 pyridoxal phosphate fibrinogen to albumin ratio leucine-rich repeat neuronal protein 2 antibody melatonin thymosin beta-4 potassium/magnesium ratio granzyme B interleukin-17A neutrophil percentage to albumin ratio whole blood viscosity peptidoglycan recognition protein 1 retinol-binding protein 4 reverse triiodothyronine apolipoprotein F very long-chain acyl-CoA synthetase appetite-regulating hormone free triiodothyronine/free thyroxine ratio threonylglycine scandium interleukin-1 receptor type 2 alpha-1-antichymotrypsin DnaJ homolog subfamily C member 2 vascular non-inflammatory molecule 3 Mac-1 cell atrial natriuretic peptide-converting enzyme superoxide dismutase endogenous thrombin potential time to peak interleukin-10 dimethylglycine cortisol CD63 antigen protein O-GlcNAcase C-X-C motif chemokine 10 pro-adrenomedullin carboxyhemoglobin red blood cell distribution width to erythrocyte count ratio oxidized low density lipoprotein type I collagen glucose tolerance test interleukin-32 atypical chemokine receptor 3 creatine kinase MM3 fish oil matrix metalloproteinase-28 alpha-1-antitrypsin tissue inhibitor of metalloproteinases beta-2 glycoprotein 1 IgA antibody S1 collagen alpha-1(III) chain anticardiolipin antibody platelet distribution width metalloproteinase inhibitor 4 C4b binding protein fibroblast growth factor 23 platelet-activating factor acetylhydrolase angiopoietin-2 serum amyloid A-1 protein thrombomodulin platelet reactivity protein S100-A9 oxidized low-density lipoprotein receptor 1 urinary pH pro-neuropeptide Y interleukin-6 receptor subunit beta oxygen saturation protein ADM2 insulin-like growth factor I lipoprotein C-reactive protein lipophilic index thrombospondin-1 endostatin heat shock protein beta-1 heme oxygenase 1 plasminogen nucleobindin-2 protein S100-A1 fibulin-1 angiopoietin-related protein 4 NACHT, LRR and PYD domains-containing protein 3 fibrinogen beta chain procalcitonin CD34+ cell neutrophil elastase high-density lipoprotein cholesterol to low-density lipoprotein cholesterol ratio thrombus precursor protein glycoprotein creatine legumain interleukin-33/suppression of tumorigenicity 2 ratio hepatocyte growth factor plasmalogen alpha-2 antiplasmin suppression of tumorigenicity 2 insulin fibrin residual platelet reactivity to adenosine diphosphate tumor necrosis factor ligand superfamily member 12 tissue factor pathway inhibitor succinate transient receptor potential cation channel subfamily V member 6 prothrombin fragments F1+2 lymphocyte to monocyte ratio proinsulin pappalysin-1 acid phosphatase phospholipase A2 urate galectin-3-binding protein anti-phosphorylcholine IgM total antioxidant status vitronectin apolipoprotein C-III pentraxin-related protein PTX3 triglyceride-rich lipoprotein particle blood clot strength apolipoprotein E hypoxia up-regulated protein 1 total iron-binding capacity vascular endothelial growth factor B triiodothyronine monocyte to high-density lipoprotein cholesterol ratio apelin-36 coagulation factor XI troponin I, cardiac muscle endothelin-1 potassium fibronectin type III domain-containing protein 5 testosterone mannose-binding protein C CD40 ligand/interleukin-10 ratio fibrinogen plasma serine protease inhibitor interleukin-33 interferon gamma plasminogen activator inhibitor-1 antigen trans fatty acid protachykinin-1 proenkephalin-A CD45-/CXCR4+/FLK-1+ cells antithrombin antigen free triiodothyronine total basophil count fibronectin beta-2 glycoprotein 1 IgM antibody neutrophil gelatinase-associated lipocalin platelet larger cell ratio protein S100-A8 11-dehydro-thromboxane B2 macrosialin tissue plasminogen activator/plasminogen activator inhibitor-1 complex interstitial collagenase coagulation factor XII complement C1q tumor necrosis factor-related protein 1 metalloproteinase inhibitor 2 bilirubin furin complement component C1q receptor C-C motif chemokine 2 interleukin-6 circulating cell-free DNA plasmin-antiplasmin complex ficolin-2 random blood glucose hematocrit matrix metalloproteinase-9 nardilysin estimated glomerular filtration rate alpha-2 macroglobulin kininogen-1 IgA antibody to endothelial protein C receptor vascular endothelial growth factor receptor 1 hepatic triacylglycerol lipase neprilysin albumin hypoxia-inducible factor 1-alpha receptor-interacting serine/threonine-protein kinase 3 neutrophil count urotensin-2 3-chlorotyrosine von Willebrand factor blood group B tumor necrosis factor receptor superfamily member 6 myosin regulatory light chain 2, ventricular/cardiac muscle isoform complement component protein angiopoietin-1 proheparin-binding EGF-like growth factor peptidyl-prolyl cis-trans isomerase A antiphospholipid antibody periostin lymphocyte count E-selectin leptin receptor serpin A12 fibroblast growth factor 2 thyroid hormone triglyceride C-C motif chemokine 3 actin, aortic smooth muscle growth/differentiation factor 8 metalloproteinase inhibitor 3 protein antigen C-type natriuretic peptide metalloproteinase inhibitor 1 malate dehydrogenase fibrinogen gamma chain derivatives of reactive oxygen metabolites creatine kinase M-type TGF-beta receptor type-1 N-acetylglycine fatty liver index endogenous thrombin potential peak height complement C1q subcomponent subunit A protein S thrombin measurement cartilage oligomeric matrix protein glutathione renin sodium tumor necrosis factor receptor superfamily member 1A selenoprotein P complement C3 adenosine deaminase unesterified fatty acid ceruloplasmin leuko-glycemic index a disintegrin and metalloproteinase with thrombospondin motifs 2 blood urea nitrogen to creatinine ratio beta-carotene creatinine immunoglobulin heavy constant epsilon complement receptor type 1 apelin beta-adrenergic receptor CX3C chemokine receptor 1 relaxin parathyroid hormone endothelial protein C receptor apolipoprotein B to apolipoprotein A1 ratio urokinase plasminogen activator surface receptor random plasma glucose nonanoylcarnitine interleukin-4 transforming growth factor beta-1 carnitine high sensitivity C-reactive protein anti-beta-2 glycoprotein 1 antibody syndecan-1 triggering receptor expressed on myeloid cells 1 resistin galectin-3 V1.0.0 Chaoying Zhan The myocardial infarction ontology (MIO) is a disease-specific ontology that characterizes the knowledge field of myocardial infarction. en myocardial infarction ontology (MIO) V1.0.0 rdfs:MIO_ID