* MPATH:$sequence(3,0,999)$ OBO-Edit 2.3-beta5 mouse_pathology.ontology 1.2 ORCID: 0000-0002-5111-7263 The Pathbase mouse pathology ontology provides a description of experimental mouse pathology phenotypes and incorporates 889 concepts including anatomical pathological entities and pathological processes. These are organised in an almost entirely is_a hierarchy of pathological processes or anatomical entities. Questions, comments and suggestions for amendment should be sent to the Co-ordinator, Dr. Paul Schofield, Dept. of Physiology Development and Neuroscience, University of Cambridge (PNS12@cam.ac.uk).The ontology was developed by the Pathbase consortium (http://www.pathbase.net) funded under the European Commission's Fifth Framework programme, Contract number QLRI-CT-1999-00320. definition namespace-id-rule has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_obo_format_version has_obo_namespace has_related_synonym mouse_pathology.ontology is_a is a mouse_pathology.ontology part_of part of Pathological structure or process mouse_pathology.ontology MPATH:0 pathological entity MPATH:0 Pathological structure or process Pathbase: Curation The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors. mouse_pathology.ontology MPATH:1 cell and tissue damage MPATH:1 The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors. Pathbase: Pathology Committee Extensive necrosis from whatever cause, often following chronic ischemia. mouse_pathology.ontology Mortification MPATH:10 gangrene MPATH:10 Extensive necrosis from whatever cause, often following chronic ischemia. ISBN:0781727286 Mortification Pathbase: Curation Defect in placental growth, differentiation of circulation; maternal or embryonic component. mouse_pathology.ontology MPATH:100 placental abnormality MPATH:100 Defect in placental growth, differentiation of circulation; maternal or embryonic component. Pathbase: Pathology Committee Phenotypic observation of the presence or absence of a pathological entity. Luke Slater mouse_pathology.ontology MPATH:1000 pathological phenotype observation MPATH:1000 Phenotypic observation of the presence or absence of a pathological entity. UOB:LTS Lack of, displacement of, or abnormality in function or growth of the glycogen cells. mouse_pathology.ontology MPATH:101 glycogen cell defect MPATH:101 Lack of, displacement of, or abnormality in function or growth of the glycogen cells. Pathbase: Curation Defect in size, cellular composition, function or organisation of the labyrinthine zone of the placenta. mouse_pathology.ontology MPATH:102 labyrinth zone defect MPATH:102 Defect in size, cellular composition, function or organisation of the labyrinthine zone of the placenta. Pathbase: Pathology Committee Any defect in the maternal or embryonic placental circulation. mouse_pathology.ontology MPATH:103 placental vascular defect MPATH:103 Any defect in the maternal or embryonic placental circulation. Pathbase: Curation Defect in size, cellular composition, function or organisation of the spongiotrophoblast zone of the placenta. mouse_pathology.ontology MPATH:104 spongiotrophoblast defect MPATH:104 Defect in size, cellular composition, function or organisation of the spongiotrophoblast zone of the placenta. Pathbase: Curation Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body. mouse_pathology.ontology MPATH:105 circulatory disorder MPATH:105 Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body. Pathbase: Pathology Committee Abnormal accumulation of fluid; blood or lymph. mouse_pathology.ontology MPATH:106 fluid accumulation MPATH:106 Abnormal accumulation of fluid; blood or lymph. Pathbase: Curation Presence of an abnormal amount of fluid (but especially of blood) in the vessels or passages of a part or organ. mouse_pathology.ontology MPATH:107 congestion MPATH:107 Presence of an abnormal amount of fluid (but especially of blood) in the vessels or passages of a part or organ. Pathbase: Pathology Committee A syndrome consequent to uncontrolled activation of blood clotting factors leading to disseminated platelet lysis, and fibrin deposition, ultimately leading to bleeding and necrosis as a consequence of inhibition of fibrin polymerisation by degradation products. mouse_pathology.ontology DIC MPATH:108 Diagnosed by microthrombi in many organs. disseminated intravascular coagulation MPATH:108 A syndrome consequent to uncontrolled activation of blood clotting factors leading to disseminated platelet lysis, and fibrin deposition, ultimately leading to bleeding and necrosis as a consequence of inhibition of fibrin polymerisation by degradation products. ISBN:0781727286 DIC Pathbase: Curation An accumulation of an excessive amount of watery fluid in cells or intercellular tissues. oedema mouse_pathology.ontology MPATH:109 edema MPATH:109 An accumulation of an excessive amount of watery fluid in cells or intercellular tissues. Pathbase: Curation Necrosis associated with local hemorrhage. mouse_pathology.ontology MPATH:11 hemorrhagic necrosis MPATH:11 Necrosis associated with local hemorrhage. ISBN:0781727286 A plug formed from a variety of materials occluding a vessel or tube. mouse_pathology.ontology MPATH:110 embolus MPATH:110 A plug formed from a variety of materials occluding a vessel or tube. Pathbase: Pathology Committee An bubble of air occluding flow through a blood or lymphatic vessel. mouse_pathology.ontology MPATH:111 air embolism MPATH:111 An bubble of air occluding flow through a blood or lymphatic vessel. Pathbase: Curation Occlusion of vessels caused by entry of amniotic fluid, cell and debris into the maternal circulation. mouse_pathology.ontology MPATH:112 amniotic fluid embolism MPATH:112 Occlusion of vessels caused by entry of amniotic fluid, cell and debris into the maternal circulation. Pathbase: Curation Occlusion of the outflow tract of the right atrium by a thrombus. mouse_pathology.ontology MPATH:113 atrial embolism MPATH:113 Occlusion of the outflow tract of the right atrium by a thrombus. Pathbase: Curation Occlusion of vessels caused by entry of bone marrow, often fatty debris into the circulation. Usually following trauma. mouse_pathology.ontology MPATH:114 bone marrow embolism MPATH:114 Occlusion of vessels caused by entry of bone marrow, often fatty debris into the circulation. Usually following trauma. Pathbase: Pathology Committee Occlusion of vessels caused by entry of lipid or fatty cells into the circulation. Usually following trauma. mouse_pathology.ontology MPATH:115 fat embolism MPATH:115 Occlusion of vessels caused by entry of lipid or fatty cells into the circulation. Usually following trauma. Pathbase: Curation Occlusion of pulmonary vessels by an embolus. mouse_pathology.ontology MPATH:116 pulmonary embolism MPATH:116 Occlusion of pulmonary vessels by an embolus. Pathbase: Curation Occlusion of vessels, usually small arterioles in the dermis by various emboli. mouse_pathology.ontology MPATH:117 skin embolism MPATH:117 Occlusion of vessels, usually small arterioles in the dermis by various emboli. Pathbase: Curation Production of systemic vessel occlusion by emboli released from the left side of the heart, or the aorta. mouse_pathology.ontology MPATH:118 systemic embolism MPATH:118 Production of systemic vessel occlusion by emboli released from the left side of the heart, or the aorta. Pathbase: Pathology Committee Abnormal release of whole blood or the cellular component from the circulation. mouse_pathology.ontology MPATH:119 hemorrhage and non-specified extravasation MPATH:119 Abnormal release of whole blood or the cellular component from the circulation. Pathbase: Curation Soft or fluid tissue remains of a circumscribed area of necrosis digested by proteolytic enzymes. mouse_pathology.ontology MPATH:12 liquefactive necrosis MPATH:12 Soft or fluid tissue remains of a circumscribed area of necrosis digested by proteolytic enzymes. ISBN:0781727286 A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae. mouse_pathology.ontology MPATH:120 May also be used for any organ, although more generally used with respect to the skin. ecchymosis MPATH:120 A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae. ISBN:0781727286 A localised deposition of clotted or partially clotted extravasated blood. mouse_pathology.ontology Bruise MPATH:121 hematoma MPATH:121 A localised deposition of clotted or partially clotted extravasated blood. ISBN:0781727286 Bruise Pathbase: Curation Small hemorrhagic spots in the skin caused by blood vessel breakdown. mouse_pathology.ontology MPATH:122 Usually used with reference to the skin but can be used in the context of other organs. petechia MPATH:122 Small hemorrhagic spots in the skin caused by blood vessel breakdown. ISBN:0781727286 Purple and variously colored lesions caused by extensive haemorrhage into the skin through ecchymoses/petechia. mouse_pathology.ontology MPATH:123 purpura MPATH:123 Purple and variously colored lesions caused by extensive haemorrhage into the skin through ecchymoses/petechia. ISBN:0781727286 An area of necrosis resulting from a sudden cessation of arterial or venous blood supply. mouse_pathology.ontology MPATH:124 infarct MPATH:124 An area of necrosis resulting from a sudden cessation of arterial or venous blood supply. Pathbase: Pathology Committee Presence of an occluding or mural thrombus in a blood vessel. mouse_pathology.ontology MPATH:125 thrombosis MPATH:125 Presence of an occluding or mural thrombus in a blood vessel. Pathbase: Curation Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs. mouse_pathology.ontology MPATH:126 growth and differentiation defect MPATH:126 Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs. Pathbase: Pathology Committee A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume. mouse_pathology.ontology MPATH:127 atrophy MPATH:127 A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume. Pathbase: Pathology Committee Non-invasive changes characterized by alteration in the size, shape and organization of the cellular components of an epithelial tissue. Do not confuse with developmental dysplasia MPATH:64. mouse_pathology.ontology intra-epithelial lesion MPATH:128 This term has been previously used as a synonym for pre-malignant dysplasia or carcinoma in situ and is now to be preferred. intra-epithelial neoplasia MPATH:128 Non-invasive changes characterized by alteration in the size, shape and organization of the cellular components of an epithelial tissue. Do not confuse with developmental dysplasia MPATH:64. Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128 intra-epithelial lesion Pathbase: Curation epithelial dysplasia mouse_pathology.ontology MPATH:129 obsolete due to renaming of preneoplastic dysplasias and Intraepithelial neoplasias Use MPATH:128. epithelial dysplasia true MPATH:129 epithelial dysplasia Pathbase: Pathology Committee Sensu; hepaticobiliary system. Loss and degeneration of hepatocytes at the portal-lobular interface producing a moth-eaten irregular appearance. Piecemeal necrosis is associated with a lymphocytic infiltrate. mouse_pathology.ontology MPATH:13 piecemeal necrosis MPATH:13 Sensu; hepaticobiliary system. Loss and degeneration of hepatocytes at the portal-lobular interface producing a moth-eaten irregular appearance. Piecemeal necrosis is associated with a lymphocytic infiltrate. ISBN:0781727286 Mild non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone. George Gkoutos mouse_pathology.ontology IENI low grade intraepithelial lesion mild epithelial dysplasia. MPATH:130 mild intra-epithelial neoplasia MPATH:130 Mild non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone. Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128 IENI Pathbase: Curation low grade intraepithelial lesion Pathbase: Curation mild epithelial dysplasia. Pathbase: Curation Moderate non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone. George Gkoutos mouse_pathology.ontology IENII high grade intraepithelial lesion moderate epithelial dysplasia MPATH:131 moderate intra-epithelial epithelial neoplasia MPATH:131 Moderate non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone. Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128 IENII Pathbase: Curation high grade intraepithelial lesion Pathbase: Curation moderate epithelial dysplasia Pathbase: Curation Severe non-invasive malignancy associated changes in cell morphology and tissue architecture confined to the epithelium alone. George Gkoutos mouse_pathology.ontology IENIII carcinoma in situ high grade intra-epithelial lesion severe epithelial dysplasia MPATH:132 Carcinoma in situ may be used in some systems as a synonym. severe intra-epithelial neoplasia MPATH:132 Severe non-invasive malignancy associated changes in cell morphology and tissue architecture confined to the epithelium alone. Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128 IENIII Pathbase: Curation carcinoma in situ Pathbase: Curation high grade intra-epithelial lesion Pathbase: Curation severe epithelial dysplasia Pathbase: Curation Small organ or structure; failure to develop to normal size. George Gkoutos mouse_pathology.ontology Developmental hypoplasia MPATH:133 hypoplasia MPATH:133 Small organ or structure; failure to develop to normal size. Pathbase: Pathology Committee Developmental hypoplasia Pathbase: Curation An increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Non -neoplastic process. George Gkoutos mouse_pathology.ontology MPATH:134 hyperplasia MPATH:134 An increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Non -neoplastic process. Pathbase: Pathology Committee Abnormal proliferation of epithelial and stromal cells. George Gkoutos mouse_pathology.ontology MPATH:135 epithelial and stromal hyperplasia MPATH:135 Abnormal proliferation of epithelial and stromal cells. Pathbase: Pathology Committee A polypoid outgrowth of both epidermis and dermal fibrovascular tissue. George Gkoutos mouse_pathology.ontology skin tag MPATH:136 fibroepithelial polyp MPATH:136 A polypoid outgrowth of both epidermis and dermal fibrovascular tissue. ISBN:0781727286 skin tag Pathbase: Curation Benign proliferation of glandular epithelium accompanied by proliferation of fibroblastic stroma. George Gkoutos mouse_pathology.ontology MPATH:137 fibroglandular hyperplasia MPATH:137 Benign proliferation of glandular epithelium accompanied by proliferation of fibroblastic stroma. Pathbase: Curation Abnormal proliferation of epithelial cells and epithelial components. George Gkoutos mouse_pathology.ontology MPATH:138 epithelial hyperplasia MPATH:138 Abnormal proliferation of epithelial cells and epithelial components. Pathbase: Pathology Committee Benign proliferation of goblet cells. George Gkoutos mouse_pathology.ontology MPATH:139 goblet cell hyperplasia MPATH:139 Benign proliferation of goblet cells. Pathbase: Curation A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell. George Gkoutos mouse_pathology.ontology MPATH:14 process of degenerative change MPATH:14 A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell. Pathbase: Pathology Committee A benign polyp, usually in the colon, showing hyperplasia. George Gkoutos mouse_pathology.ontology MPATH:140 hyperplastic polyp MPATH:140 A benign polyp, usually in the colon, showing hyperplasia. ISBN:0781727286 A projecting mass of granulation tissue which may become covered by regenerating epithelium. George Gkoutos mouse_pathology.ontology pseudopolyp MPATH:141 inflammatory polyp MPATH:141 A projecting mass of granulation tissue which may become covered by regenerating epithelium. ISBN:0781727286 pseudopolyp Pathbase: Curation Benign hyperplasia of the ducts of the mammary gland. Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) without cytological atypia. George Gkoutos mouse_pathology.ontology MPATH:142 intraductal hyperplasia MPATH:142 Benign hyperplasia of the ducts of the mammary gland. Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) without cytological atypia. PMID:10713680 Benign proliferation of glandular epithelia, eg. Endocervical glands. Consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium. George Gkoutos mouse_pathology.ontology microglandular adenosis MPATH:143 microglandular hyperplasia MPATH:143 Benign proliferation of glandular epithelia, eg. Endocervical glands. Consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium. ISBN:0781727286 microglandular adenosis Pathbase: Curation Benign proliferation of glandular myoepithelial cells. George Gkoutos mouse_pathology.ontology MPATH:144 myoepithelial hyperplasia MPATH:144 Benign proliferation of glandular myoepithelial cells. Pathbase: Curation Benign proliferation of adipose tissue. George Gkoutos mouse_pathology.ontology MPATH:145 fat cell hyperplasia MPATH:145 Benign proliferation of adipose tissue. Pathbase: Pathology Committee true MPATH:146 Benign enlargement of lymphoid tissues. George Gkoutos mouse_pathology.ontology lymphoid hypertrophy MPATH:147 lymphoid hyperplasia MPATH:147 Benign enlargement of lymphoid tissues. Pathbase: Pathology Committee lymphoid hypertrophy Pathbase: Curation Benign proliferation of mesothelial cells lining body cavities presenting as small solid cell clusters or multiple layers with columnar morphology and delicate eosinophilic cytoplasm. George Gkoutos mouse_pathology.ontology mesothelioma MPATH:148 mesothelial hyperplasia MPATH:148 Benign proliferation of mesothelial cells lining body cavities presenting as small solid cell clusters or multiple layers with columnar morphology and delicate eosinophilic cytoplasm. Pathbase: Mohr mesothelioma Pathbase: Curation Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia). George Gkoutos mouse_pathology.ontology epidermal hyperplasia. squamous cell hyperplasia MPATH:149 squamous hyperplasia MPATH:149 Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia). Pathbase: Pathology Committee epidermal hyperplasia. Pathbase: Curation squamous cell hyperplasia Pathbase: Curation Change of tissue to a lower state of integrity or less functional form, as in heart failure. George Gkoutos mouse_pathology.ontology MPATH:15 general degenerative process MPATH:15 Change of tissue to a lower state of integrity or less functional form, as in heart failure. Pathbase: Pathology Committee Hyperplasia of the Malpighian layer (prickle cell) of the epidermis. George Gkoutos mouse_pathology.ontology MPATH:150 acanthosis MPATH:150 Hyperplasia of the Malpighian layer (prickle cell) of the epidermis. ISBN:0781727286 Discrete, flat or elevated, verrucous, keratotic lesions. Epidermal changes are characterized by acanthosis, parakeratosis, and dyskeratoses. Dysplastic change is present and the keratinocytes vary in size and shape. Associated with UV exposure in humans. Not defined in mice to date. George Gkoutos mouse_pathology.ontology MPATH:151 actinic keratosis MPATH:151 Discrete, flat or elevated, verrucous, keratotic lesions. Epidermal changes are characterized by acanthosis, parakeratosis, and dyskeratoses. Dysplastic change is present and the keratinocytes vary in size and shape. Associated with UV exposure in humans. Not defined in mice to date. Pathbase: Pathology Committee Benign proliferation of the basal layer cells of the skin. George Gkoutos mouse_pathology.ontology MPATH:152 basal cell hyperplasia MPATH:152 Benign proliferation of the basal layer cells of the skin. Pathbase: Curation Increased thickness of the granular layer of a stratified squamous epithelium, associated with hyperorthokeratosis. George Gkoutos mouse_pathology.ontology MPATH:153 hypergranulosis MPATH:153 Increased thickness of the granular layer of a stratified squamous epithelium, associated with hyperorthokeratosis. Pathbase: Pathology Committee Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis. George Gkoutos mouse_pathology.ontology cornification hyperorthokeratosis hyperparakeratosis MPATH:154 hyperkeratosis MPATH:154 Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis. Pathbase: Pathology Committee cornification Pathbase: Curation hyperorthokeratosis Pathbase: Curation hyperparakeratosis Pathbase: Curation Thickening of the anuclear cell layer limited to the stratum corneum, as in a stratified squamous epithelium. George Gkoutos mouse_pathology.ontology MPATH:155 orthokeratosis MPATH:155 Thickening of the anuclear cell layer limited to the stratum corneum, as in a stratified squamous epithelium. Pathbase: Pathology Committee Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum. George Gkoutos mouse_pathology.ontology MPATH:156 parakeratosis MPATH:156 Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum. Pathbase: Pathology Committee Benign hyperplasia and down-growth of epidermal cells. Microscopically resembling well-differentiated squamous cell carcinoma. George Gkoutos mouse_pathology.ontology pseudocarcinoma pseudocarcinomatous hyperplasia pseudoepitheliomatous hyperplasia MPATH:157 pseudoepithelioma/pseudocarcinoma MPATH:157 Benign hyperplasia and down-growth of epidermal cells. Microscopically resembling well-differentiated squamous cell carcinoma. ISBN:0781727286 pseudocarcinoma Pathbase: Curation pseudocarcinomatous hyperplasia Pathbase: Curation pseudoepitheliomatous hyperplasia Pathbase: Curation Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing cornifying cysts. George Gkoutos mouse_pathology.ontology Basal cell papilloma seborrheic verruca MPATH:158 seborrheic keratosis MPATH:158 Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing cornifying cysts. ISBN:0781727286 Basal cell papilloma Pathbase: Curation seborrheic verruca Pathbase: Curation Increase in size or mass of a cell, tissue or organ without increase in cell proliferation. Cf. Hyperplasia MPATH: 133. George Gkoutos mouse_pathology.ontology MPATH:159 hypertrophy MPATH:159 Increase in size or mass of a cell, tissue or organ without increase in cell proliferation. Cf. Hyperplasia MPATH: 133. Pathbase: Pathology Committee A conversion of the connective tissues into a gelatinous or mucous substance. George Gkoutos mouse_pathology.ontology Mucoid degeneration myxomatosis MPATH:16 myxoid/myxomatous degeneration MPATH:16 Mucoid degeneration Pathbase: Curation myxomatosis Pathbase: Curation A conversion of the connective tissues into a gelatinous or mucous substance. ISBN:0781727286 Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced. George Gkoutos mouse_pathology.ontology MPATH:160 metaplasia MPATH:160 Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced. Pathbase: Pathology Committee Metaplasia resulting in heterotopic formation of cartilage. George Gkoutos mouse_pathology.ontology MPATH:161 cartilaginous metaplasia MPATH:161 Metaplasia resulting in heterotopic formation of cartilage. ISBN:0781727286 Metaplasia occurring within epithelia. George Gkoutos mouse_pathology.ontology MPATH:162 epithelial metaplasia MPATH:162 Metaplasia occurring within epithelia. ISBN:0781727286 Alteration of acinar epithelium of, for example, mammary tissue to resemble apocrine glands. George Gkoutos mouse_pathology.ontology MPATH:163 apocrine metaplasia MPATH:163 Alteration of acinar epithelium of, for example, mammary tissue to resemble apocrine glands. ISBN:0781727286 Appearance of heterotopic gastric epithelium. George Gkoutos mouse_pathology.ontology MPATH:164 gastric metaplasia MPATH:164 Appearance of heterotopic gastric epithelium. ISBN:0781727286 Development of heterotopic glandular epithelia. George Gkoutos mouse_pathology.ontology MPATH:165 glandular metaplasia MPATH:165 Development of heterotopic glandular epithelia. ISBN:0781727286 Metaplasia resulting in formation of mucus secreting goblet cells. George Gkoutos mouse_pathology.ontology MPATH:166 goblet cell metaplasia MPATH:166 Metaplasia resulting in formation of mucus secreting goblet cells. ISBN:0781727286 Appearance of heterotopic intestinal epithelium. George Gkoutos mouse_pathology.ontology MPATH:167 intestinal metaplasia MPATH:167 Appearance of heterotopic intestinal epithelium. ISBN:0781727286 Metaplasia resulting in formation of fat cells. George Gkoutos mouse_pathology.ontology MPATH:168 lipomatous metaplasia MPATH:168 Metaplasia resulting in formation of fat cells. ISBN:0781727286 .A rare benign neoplasm of the mucosa of the urinary bladder or the urethra, consisting of tubular structures resembling those of the nephron. George Gkoutos mouse_pathology.ontology nephrogenic adenoma MPATH:169 nephrogenic metaplasia MPATH:169 .A rare benign neoplasm of the mucosa of the urinary bladder or the urethra, consisting of tubular structures resembling those of the nephron. ISBN:0781727286 nephrogenic adenoma Pathbase: Curation Defect of a subcellular structure or organelle. George Gkoutos mouse_pathology.ontology MPATH:17 subcellular defect MPATH:17 Defect of a subcellular structure or organelle. Pathbase: Pathology Committee Appearance of oncocytic cells in for example an epithelium or tumor. George Gkoutos mouse_pathology.ontology MPATH:170 An oncocyte is an acidophilic cell containing numerous mitochondria - an oxophil cell. oncocytic metaplasia MPATH:170 Appearance of oncocytic cells in for example an epithelium or tumor. ISBN:0781727286 Change of a glandular or mucosal epithelium into squamous epithelium. George Gkoutos mouse_pathology.ontology MPATH:171 squamous metaplasia MPATH:171 Change of a glandular or mucosal epithelium into squamous epithelium. ISBN:0781727286 Metaplastic response of the transitional epithelium, for example in the bladder to give squamous metaplasia and glandular metaplasia for example. George Gkoutos mouse_pathology.ontology MPATH:172 transitional cell metaplasia MPATH:172 Metaplastic response of the transitional epithelium, for example in the bladder to give squamous metaplasia and glandular metaplasia for example. ISBN:0781727286 A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow. George Gkoutos mouse_pathology.ontology MPATH:173 myeloid metaplasia MPATH:173 A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow. ISBN:0781727286 Metaplasia resulting in formation of bone. George Gkoutos ectopic bone mouse_pathology.ontology MPATH:174 osseous metaplasia MPATH:174 Metaplasia resulting in formation of bone. ISBN:0781727286 The process, normal or abnormal, of damage repair or wound closure. George Gkoutos mouse_pathology.ontology MPATH:175 healing and repair process MPATH:175 The process, normal or abnormal, of damage repair or wound closure. Pathbase: Pathology Committee Replacement of connective tissue by fibro-fatty deposits and scar tissue. George Gkoutos mouse_pathology.ontology MPATH:176 connective tissue replacement MPATH:176 Replacement of connective tissue by fibro-fatty deposits and scar tissue. Pathbase: Curation Aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network by vasculogenesis. George Gkoutos mouse_pathology.ontology neovascularisation MPATH:177 angiogenesis MPATH:177 Aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network by vasculogenesis. Pathbase: Curation Abnormal deposition of extracellular matrix proteins or other components. George Gkoutos mouse_pathology.ontology MPATH:178 extracellular matrix deposition MPATH:178 Abnormal deposition of extracellular matrix proteins or other components. Pathbase: Curation Deposition of fibrin. George Gkoutos mouse_pathology.ontology MPATH:179 fibrin deposition MPATH:179 Deposition of fibrin. Pathbase: Curation Defect in the structure or function of the cytoskeleton. George Gkoutos mouse_pathology.ontology MPATH:18 cytoskeletal defect MPATH:18 Defect in the structure or function of the cytoskeleton. Pathbase: Pathology Committee Abnormal or reactive proliferation of fibroblasts. George Gkoutos mouse_pathology.ontology MPATH:180 fibroblast proliferation MPATH:180 Abnormal or reactive proliferation of fibroblasts. Pathbase: Curation Reactive formation of fibrous tissue. George Gkoutos mouse_pathology.ontology MPATH:181 fibrosis MPATH:181 Reactive formation of fibrous tissue. Pathbase: Curation Proliferation of astrocytes in an area of damage in the brain or spinal cord. George Gkoutos mouse_pathology.ontology MPATH:182 gliosis MPATH:182 Proliferation of astrocytes in an area of damage in the brain or spinal cord. Pathbase: Curation Newly formed connective (vascular or fibrous)tissue caused by inflammation or healing (repair) processes. Microscopically consists of capillaries fibroblastic cells and inflammatory cells. George Gkoutos mouse_pathology.ontology MPATH:183 granulation tissue MPATH:183 Newly formed connective (vascular or fibrous)tissue caused by inflammation or healing (repair) processes. Microscopically consists of capillaries fibroblastic cells and inflammatory cells. Pathbase: Pathology Committee Any pathological thickening or hardening of a tissue. George Gkoutos mouse_pathology.ontology Induration MPATH:184 sclerosis MPATH:184 Any pathological thickening or hardening of a tissue. Pathbase: Curation Induration Pathbase: Curation Post-injury regeneration of the functional tissue parenchyma. Eg. Liver. George Gkoutos mouse_pathology.ontology MPATH:185 parenchymal regeneration MPATH:185 Post-injury regeneration of the functional tissue parenchyma. Eg. Liver. Pathbase: Curation Complete healing through parenchymal regeneration - no fibrosis. George Gkoutos mouse_pathology.ontology MPATH:186 complete parenchymal regeneration MPATH:186 Complete healing through parenchymal regeneration - no fibrosis. Pathbase: Curation Incomplete healing usually accompanied by fibrosis. George Gkoutos mouse_pathology.ontology MPATH:187 incomplete parenchymal regeneration MPATH:187 Incomplete healing usually accompanied by fibrosis. Pathbase: Pathology Committee Inappropriate or aberrant activation or suppression of the immune or inflammatory response. George Gkoutos mouse_pathology.ontology MPATH:188 immunopathological process MPATH:188 Inappropriate or aberrant activation or suppression of the immune or inflammatory response. Pathbase: Pathology Committee Immune response resulting in tissue injury. George Gkoutos mouse_pathology.ontology MPATH:189 hypersensitivity disease MPATH:189 Immune response resulting in tissue injury. Pathbase: Curation Defect in the structure or function of the endoplasmic reticulum. George Gkoutos mouse_pathology.ontology MPATH:19 endoplasmic reticulum defect MPATH:19 Defect in the structure or function of the endoplasmic reticulum. Pathbase: Pathology Committee This is manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized. It is IgE-mediated, and mast cell activation and degranulation are hallmarks. George Gkoutos mouse_pathology.ontology MPATH:190 type I hypersensitivity MPATH:190 This is manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized. It is IgE-mediated, and mast cell activation and degranulation are hallmarks. ISBN:0781727286 Caused by an antibody/antigen reaction: antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues. George Gkoutos mouse_pathology.ontology MPATH:191 Most often involves IgG and IgM. Complement activation is usually involved. type II hypersensitivity MPATH:191 Caused by an antibody/antigen reaction: antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues. ISBN:0781727286 Tissue injury mediated by immune complexes. Generally involves immune complexes formed in the blood via antibodies encountering circulating antigens. Immune complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury. George Gkoutos mouse_pathology.ontology MPATH:192 type III hypersensitivity MPATH:192 Tissue injury mediated by immune complexes. Generally involves immune complexes formed in the blood via antibodies encountering circulating antigens. Immune complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury. ISBN:0781727286 An antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation. The response is seen at the area of contact. George Gkoutos mouse_pathology.ontology MPATH:193 type IV hypersensitivity MPATH:193 An antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation. The response is seen at the area of contact. ISBN:0781727286 Tissue response to inappropriate immune/inflammatory process. George Gkoutos mouse_pathology.ontology MPATH:194 immune mediated disease MPATH:194 Tissue response to inappropriate immune/inflammatory process. Pathbase: Curation Inflammation of a joint. George Gkoutos mouse_pathology.ontology MPATH:195 arthritis MPATH:195 Inflammation of a joint. Pathbase: Curation Inflammation of the skin. George Gkoutos mouse_pathology.ontology MPATH:196 dermatitis MPATH:196 Inflammation of the skin. Pathbase: Curation Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment. George Gkoutos mouse_pathology.ontology MPATH:197 glomerulonephritis MPATH:197 Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment. Pathbase: Curation An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction. George Gkoutos mouse_pathology.ontology MPATH:198 immune mediated hemolytic anaemia MPATH:198 An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction. ISBN:0781727286 A condition resulting from an increased rate of immune mediated platelet destruction. George Gkoutos mouse_pathology.ontology MPATH:199 immune mediated thrombocytopenia MPATH:199 A condition resulting from an increased rate of immune mediated platelet destruction. ISBN:0781727286 Complete and irreversible cessation of metabolic activity. George Gkoutos mouse_pathology.ontology MPATH:2 cell death MPATH:2 Complete and irreversible cessation of metabolic activity. Pathbase: Pathology Committee Defect in the structure or function of the golgi apparatus. George Gkoutos mouse_pathology.ontology MPATH:20 golgi defect MPATH:20 Defect in the structure or function of the golgi apparatus. Pathbase: Pathology Committee Inflammation of a muscle. George Gkoutos mouse_pathology.ontology Initis MPATH:200 myositis MPATH:200 Inflammation of a muscle. Pathbase: Curation Initis Pathbase: Curation Inflammation of a blood vessel. George Gkoutos mouse_pathology.ontology angiitis arteritis lymphangiitis phlebitis MPATH:201 vasculitis MPATH:201 Inflammation of a blood vessel. Pathbase: Pathology Committee angiitis Pathbase: Curation arteritis Pathbase: Curation lymphangiitis Pathbase: Curation phlebitis Pathbase: Curation Defective immune response; can be primary due to defect in immune system or secondary/acquired due to disease. George Gkoutos mouse_pathology.ontology MPATH:202 immunodeficiency disease MPATH:202 Defective immune response; can be primary due to defect in immune system or secondary/acquired due to disease. Pathbase: Curation general immunodeficiency disease mouse_pathology.ontology MPATH:203 obsolete. Subsumed into MPATH:202 general immunodeficiency disease true MPATH:203 general immunodeficiency disease Pathbase: Curation chronic/recurrent inflammatory disease mouse_pathology.ontology MPATH:204 obsolete. Subsumed into MPATH: 214. chronic/recurrent inflammatory disease true MPATH:204 chronic/recurrent inflammatory disease Pathbase: Curation Infection with bacteria, viruses or fungi subsequent to immunodeficiency. mouse_pathology.ontology MPATH:205 immunodeficiency associated infection true MPATH:205 Infection with bacteria, viruses or fungi subsequent to immunodeficiency. Pathbase: Pathology Committee Disease due to primary molecular or cellular defect in the immune system or its development. George Gkoutos mouse_pathology.ontology MPATH:206 primary immunodeficiency disease MPATH:206 Disease due to primary molecular or cellular defect in the immune system or its development. Pathbase: Curation Primary defect in the lymphoid arm of the immune system. George Gkoutos mouse_pathology.ontology MPATH:207 immunodeficiency - lymphoid defect MPATH:207 Primary defect in the lymphoid arm of the immune system. Pathbase: Curation Primary defect in the myeloid arm of the immune system. George Gkoutos mouse_pathology.ontology MPATH:208 immunodeficiency - myeloid/phagocytic defect MPATH:208 Primary defect in the myeloid arm of the immune system. Pathbase: Curation Defect in the immune system subsequent to external injury, infection, ablation or deficiency. George Gkoutos mouse_pathology.ontology MPATH:209 secondary immunodeficiency disease MPATH:209 Defect in the immune system subsequent to external injury, infection, ablation or deficiency. Pathbase: Curation Defect in the structure or function of the lysosomes. George Gkoutos mouse_pathology.ontology MPATH:21 lysosomal defect MPATH:21 Defect in the structure or function of the lysosomes. Pathbase: Curation Defect in the immune system subsequent to external injury, infection or ablation. George Gkoutos mouse_pathology.ontology MPATH:210 acquired immunodeficiency MPATH:210 Defect in the immune system subsequent to external injury, infection or ablation. Pathbase: Curation Defect in the immune system subsequent to failure to attain passive immunity from maternal transfer of immunoglobulins. George Gkoutos mouse_pathology.ontology MPATH:211 failed transfer of maternal immunoglobulin MPATH:211 Defect in the immune system subsequent to failure to attain passive immunity from maternal transfer of immunoglobulins. Pathbase: Pathology Committee A tissue reaction to an internal or external injury. George Gkoutos mouse_pathology.ontology MPATH:212 inflammation MPATH:212 A tissue reaction to an internal or external injury. Pathbase: Pathology Committee Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia. George Gkoutos mouse_pathology.ontology MPATH:213 The five classical signs of inflammation: Rubor, tumor, calor, dolor, functio laesa (Galen 300BC). acute inflammation MPATH:213 Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia. Pathbase: Pathology Committee Chronic inflammatory condition characterised by infiltration of primarily lymphocytes. George Gkoutos mouse_pathology.ontology MPATH:214 chronic inflammation MPATH:214 Chronic inflammatory condition characterised by infiltration of primarily lymphocytes. Pathbase: Pathology Committee Nodular inflammatory reaction, containing compactly grouped epithelioid cells, giant cells, and other macrophages. The basic inflammatory unit is termed a granuloma. George Gkoutos mouse_pathology.ontology MPATH:215 granulomatous inflammation MPATH:215 Nodular inflammatory reaction, containing compactly grouped epithelioid cells, giant cells, and other macrophages. The basic inflammatory unit is termed a granuloma. ISBN:0781727286 Acute inflammatory reaction in which the predominant histological change is rapid diffuse necrosis throughout the affected tissue. George Gkoutos mouse_pathology.ontology MPATH:216 necrotic inflammation MPATH:216 Acute inflammatory reaction in which the predominant histological change is rapid diffuse necrosis throughout the affected tissue. ISBN:0781727286 Combination of inflammation, often suppurative or granulomatous, with ulceration. mouse_pathology.ontology MPATH:217 Ulcers may be a component or inflammation. Use MPATH: Ulcer ulcerative inflammation true MPATH:217 Combination of inflammation, often suppurative or granulomatous, with ulceration. ISBN:0781727286 A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant. George Gkoutos mouse_pathology.ontology MPATH:218 neoplasm MPATH:218 A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant. Pathbase: Pathology Committee Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures. George Gkoutos mouse_pathology.ontology MPATH:219 adnexal and skin appendage tumor MPATH:219 Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures. Pathbase: Curation Defect in the structure or function of the mitochondria. George Gkoutos mouse_pathology.ontology MPATH:22 mitochondrial defect MPATH:22 Defect in the structure or function of the mitochondria. Pathbase: Curation Carcinoma of the glandular epithelium of apocrine glands (M-8401/3). George Gkoutos mouse_pathology.ontology MPATH:220 apocrine adenocarcinoma MPATH:220 Carcinoma of the glandular epithelium of apocrine glands (M-8401/3). Pathbase: Pathology Committee Benign neoplasm of the epithelium of apocrine glands (M-8401/0). George Gkoutos mouse_pathology.ontology MPATH:221 apocrine adenoma MPATH:221 Benign neoplasm of the epithelium of apocrine glands (M-8401/0). Pathbase: Curation Malignant carcinoma of the ceruminous gland (M-8420/3). George Gkoutos mouse_pathology.ontology MPATH:222 ceruminous adenocarcinoma MPATH:222 Malignant carcinoma of the ceruminous gland (M-8420/3). Pathbase: Curation Benign adenomatous neoplasia of the ceruminous glands of the external auditory meatus (M-8420/0). mouse_pathology.ontology MPATH:223 ceruminous adenoma MPATH:223 Benign adenomatous neoplasia of the ceruminous glands of the external auditory meatus (M-8420/0). Pathbase: Curation Tumor derived from eccrine sweat glands composed of clear glycogen rich cells. ( M-84020 ). mouse_pathology.ontology Eccrine acrospiroma nodular hidradenoma MPATH:224 clear cell hidradenoma MPATH:224 Tumor derived from eccrine sweat glands composed of clear glycogen rich cells. ( M-84020 ). Pathbase: Curation Eccrine acrospiroma Pathbase: Curation nodular hidradenoma Pathbase: Curation Malignant neoplasm of the eccrine gland (M-8413/3). mouse_pathology.ontology MPATH:225 eccrine gland adenocarcinoma MPATH:225 Malignant neoplasm of the eccrine gland (M-8413/3). Pathbase: Curation Benign neoplasm of the eccrine gland (M-8408/0). mouse_pathology.ontology MPATH:226 eccrine gland adenoma MPATH:226 Benign neoplasm of the eccrine gland (M-8408/0). :Papillary adenoma Papillary form of eccrine sweat gland adenoma. (M -8408/0). mouse_pathology.ontology Papillary adenoma benign neoplasm of the eccrine gland, papillary form MPATH:227 eccrine papillary adenoma MPATH:227 Papillary form of eccrine sweat gland adenoma. (M -8408/0). Pathbase: Pathology Committee Papillary adenoma Pathbase: Curation benign neoplasm of the eccrine gland, papillary form Pathbase: Curation Benign apocrine sweat gland tumor (8405/0). mouse_pathology.ontology Hidradenoma papilliferum MPATH:228 papillary hidradenoma MPATH:228 Benign apocrine sweat gland tumor (8405/0). Pathbase: Curation Hidradenoma papilliferum Pathbase: Curation Malignant neoplasm of the sebaceous cells - rare areas of differentiation, severe nuclear atypia (M-8410/3). mouse_pathology.ontology sebaceous carcinoma MPATH:229 sebaceous adenocarcinoma MPATH:229 Malignant neoplasm of the sebaceous cells - rare areas of differentiation, severe nuclear atypia (M-8410/3). Pathbase: Curation sebaceous carcinoma Pathbase: Curation Defect in the structure or function of the peroxysomes. mouse_pathology.ontology MPATH:23 peroxysomal defect MPATH:23 Defect in the structure or function of the peroxysomes. Pathbase: Curation Adenoma of sebaceous cells; regular architecture of gland not mantained. Large numbers of immature germinative cells present. Mitoses. (M-8410/0). mouse_pathology.ontology Epithelioma MPATH:230 sebaceous adenoma MPATH:230 Adenoma of sebaceous cells; regular architecture of gland not mantained. Large numbers of immature germinative cells present. Mitoses. (M-8410/0). Pathbase: Curation Epithelioma Pathbase: Curation A benign, often multiple, sometimes eruptive neoplasm of the sweat gland ducts composed of very small round cysts. (M-8407/0). mouse_pathology.ontology MPATH:231 syringoma MPATH:231 A benign, often multiple, sometimes eruptive neoplasm of the sweat gland ducts composed of very small round cysts. (M-8407/0). Pathbase: Curation Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0). mouse_pathology.ontology Epithelioma adenoides cysticum benign hair follicle tumor MPATH:232 trichoepithelioma MPATH:232 Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0). URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models Epithelioma adenoides cysticum Pathbase: Curation benign Pathbase: Curation hair follicle tumor Pathbase: Curation Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0). mouse_pathology.ontology Benign basal cell tumor basal cell adenoma MPATH:233 basal cell tumor MPATH:233 Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0). Pathbase: Pathology Committee Benign basal cell tumor Pathbase: Curation basal cell adenoma Pathbase: Curation Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3). mouse_pathology.ontology MPATH:234 basal cell carcinoma MPATH:234 Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3). URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models Tumor of venous or arterial vessels or capillaries. mouse_pathology.ontology MPATH:235 blood vessel tumor MPATH:235 Tumor of venous or arterial vessels or capillaries. Pathbase: Pathology Committee .A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0). mouse_pathology.ontology Telangiectatic fibroma MPATH:236 angiofibroma MPATH:236 .A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0). Pathbase: Curation Telangiectatic fibroma Pathbase: Curation An intradermal capillary telangiectasis with hyperkeratosis and acanthosis (M-9141/0). mouse_pathology.ontology keratoangioma telangiectasia verrucosa telangiectatic wart MPATH:237 angiokeratoma MPATH:237 An intradermal capillary telangiectasis with hyperkeratosis and acanthosis (M-9141/0). Pathbase: Curation keratoangioma Pathbase: Curation telangiectasia verrucosa Pathbase: Curation telangiectatic wart Pathbase: Curation A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1). mouse_pathology.ontology Angioblastoma MPATH:238 hemangioblastoma MPATH:238 A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1). Pathbase: Pathology Committee Angioblastoma Pathbase: Curation hemangioendothelioma mouse_pathology.ontology MPATH:239 obsolete Use Hemangioma MPATH: 240 hemangioendothelioma true MPATH:239 hemangioendothelioma Pathbase: Curation Defect in the structure or function of the plasma membrane. mouse_pathology.ontology MPATH:24 plasma membrane defect MPATH:24 Defect in the structure or function of the plasma membrane. Pathbase: Curation Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively). mouse_pathology.ontology Angioendothelioma. Hemangioendothelioma, benign MPATH:240 hemangioma MPATH:240 Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively). PMID:8569146 Angioendothelioma. Pathbase: Curation Hemangioendothelioma, benign Pathbase: Curation A vascular, usually benign, neoplasm composed of round and spindle cells derived from the pericytes and surround endothelium-lined vessels. (M-9150/0/1/3). mouse_pathology.ontology Pericytoma MPATH:241 hemangiopericytoma MPATH:241 A vascular, usually benign, neoplasm composed of round and spindle cells derived from the pericytes and surround endothelium-lined vessels. (M-9150/0/1/3). Pathbase: Pathology Committee Pericytoma Pathbase: Curation Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3). mouse_pathology.ontology Hemangioma malignant hemangioendothelioma malignant, angiosarcoma hemangioendothelioma malignant. MPATH:242 hemangiosarcoma MPATH:242 Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3). PMID:8569146 Hemangioma malignant Pathbase: Curation hemangioendothelioma malignant, angiosarcoma Pathbase: Curation hemangioendothelioma malignant. Pathbase: Curation Neoplasm of the neurones, glia or meninges of the CNS. mouse_pathology.ontology MPATH:243 central nervous system tumor MPATH:243 Neoplasm of the neurones, glia or meninges of the CNS. Pathbase: Curation Glioma derived from astrocytes, both benign and malignant forms (M-9400/3). mouse_pathology.ontology Astrocytic glioma astroglioma MPATH:244 Also see comments in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. astrocytoma MPATH:244 Glioma derived from astrocytes, both benign and malignant forms (M-9400/3). ISBN-13:9783794515530 Astrocytic glioma Pathbase: Curation astroglioma Pathbase: Curation Malignant neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/3). mouse_pathology.ontology MPATH:245 choroid plexus carcinoma MPATH:245 Malignant neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/3). ISBN-13:9783794515530 Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0). mouse_pathology.ontology MPATH:246 choroid plexus papilloma MPATH:246 Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0). ISBN-13:9783794515530 Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3). mouse_pathology.ontology MPATH:247 Also see general scheme in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. ependymoma MPATH:247 Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3). ISBN-13:9783794515530 ependymoma malignant mouse_pathology.ontology MPATH:248 obsolete -subsumed into MPATH:247 ependymoma malignant true MPATH:248 ependymoma malignant Pathbase: Curation Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3). mouse_pathology.ontology MPATH:249 Also see comments in: Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. glioma MPATH:249 Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3). ISBN-13:9783794515530 Degenerative process characteristic of a particular tissue. mouse_pathology.ontology MPATH:25 tissue specific degenerative process MPATH:25 Degenerative process characteristic of a particular tissue. Pathbase: Curation Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS. mouse_pathology.ontology MPATH:250 Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. medulloblastoma MPATH:250 Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS. ISBN-13:9783794515530 meningioma mouse_pathology.ontology Sarcoma, meningeal ( sensu malignant tumor) MPATH:251 Benign or malignant neoplasm derived from the meninges. (M-9530/0). meningioma MPATH:251 meningioma ISBN-13:9783794515530 Sarcoma, meningeal ( sensu malignant tumor) Pathbase: Curation Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3). mouse_pathology.ontology Glioma, oligodendritic, benign glioma oligodendritic, malignant MPATH:252 Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. oligodendroglioma MPATH:252 Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3). ISBN-13:9783794515530 Glioma, oligodendritic, benign Pathbase: Curation glioma oligodendritic, malignant Pathbase: Curation Neoplasm derived from sub-ependymal astrocytes (M-9383/1). mouse_pathology.ontology MPATH:253 Also see general scheme in Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. sub-ependymoma MPATH:253 Neoplasm derived from sub-ependymal astrocytes (M-9383/1). ISBN-13:9783794515530 Tumors showing multiple histological componants/differentiation. mouse_pathology.ontology MPATH:254 complex tumor MPATH:254 Tumors showing multiple histological componants/differentiation. Pathbase: Pathology Committee Mixed tumor of glandular epithelia with squamous and glandular diffferentiation. (M-8570/3). mouse_pathology.ontology adenoid squamous cell carcinoma MPATH:255 adenoacanthoma MPATH:255 Mixed tumor of glandular epithelia with squamous and glandular diffferentiation. (M-8570/3). Pathbase: Curation adenoid squamous cell carcinoma Pathbase: Curation Possible origin from smooth muscle cells or pluripotential embryonic mesenchymal cells. May show up to three cellular componants including carcinoma and sarcoma type appearances. (M-8980/3). mouse_pathology.ontology MPATH:256 carcinosarcoma MPATH:256 Possible origin from smooth muscle cells or pluripotential embryonic mesenchymal cells. May show up to three cellular componants including carcinoma and sarcoma type appearances. (M-8980/3). Pathbase: Curation A benign or malignant neoplasm, which may be cystic, developing from the epithelium of Rathke`s pouch and occuring with or close to the pituitary gland. (M-9350/1). mouse_pathology.ontology Erdheim tumor Pituitary adamantinoma Rathke pouch tumor pituitary ameloblastoma suprasellar cyst MPATH:257 craniopharyngioma MPATH:257 A benign or malignant neoplasm, which may be cystic, developing from the epithelium of Rathke`s pouch and occuring with or close to the pituitary gland. (M-9350/1). Pathbase: Pathology Committee Erdheim tumor Pathbase: Curation Pituitary adamantinoma Pathbase: Curation Rathke pouch tumor Pathbase: Curation pituitary ameloblastoma Pathbase: Curation suprasellar cyst Pathbase: Curation Neoplasm showing multiple phases, derived from mesoderm (M-8951/3). mouse_pathology.ontology MPATH:258 mesodermal mixed tumor MPATH:258 Neoplasm showing multiple phases, derived from mesoderm (M-8951/3). Pathbase: Curation Most commonly a salivary gland carcinoma of low grade malignancy composed of mucous, epidermoid, and intermediate cells. (M-8430/3). mouse_pathology.ontology MPATH:259 mucoepidermoid carcinoma MPATH:259 Most commonly a salivary gland carcinoma of low grade malignancy composed of mucous, epidermoid, and intermediate cells. (M-8430/3). Pathbase: Curation Absence of hair or loss of hair. mouse_pathology.ontology MPATH:26 alopecia MPATH:26 Absence of hair or loss of hair. ISBN:0781727286 Neoplasm usually of the uterus or adnexae containing carcinomatous and sarcomatous elements, sometimes with third or fourth components. (M-8950/3). mouse_pathology.ontology MPATH:260 mullerian mixed tumor MPATH:260 Neoplasm usually of the uterus or adnexae containing carcinomatous and sarcomatous elements, sometimes with third or fourth components. (M-8950/3). Pathbase: Pathology Committee Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3). mouse_pathology.ontology nephroma MPATH:261 nephroblastoma MPATH:261 Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3). Pathbase: Pathology Committee nephroma Pathbase: Curation A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3). mouse_pathology.ontology MPATH:262 pulmonary blastoma MPATH:262 A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3). Pathbase: Pathology Committee Sarcomatous tumors, presenting a wide histological, ultrastructural, and immunocytochemical spectrum. M-8963/3. mouse_pathology.ontology Malignant rhabdoid tumor MPATH:263 rhabdoid sarcoma MPATH:263 Sarcomatous tumors, presenting a wide histological, ultrastructural, and immunocytochemical spectrum. M-8963/3. Pathbase: Curation Malignant rhabdoid tumor Pathbase: Curation Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030). mouse_pathology.ontology MPATH:264 fibroepithelial tumor MPATH:264 Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030). Pathbase: Curation A benign neoplasm composed of glandular and fibrous tissues, predominantly glandular. (M-9013/0). mouse_pathology.ontology Cystadenofibroma papillary adenofibroma MPATH:265 adenofibroma MPATH:265 A benign neoplasm composed of glandular and fibrous tissues, predominantly glandular. (M-9013/0). Pathbase: Curation Cystadenofibroma Pathbase: Curation papillary adenofibroma Pathbase: Curation A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0). mouse_pathology.ontology MPATH:266 fibroadenoma MPATH:266 A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0). Pathbase: Curation Neoplasms derived from glandular epithelial cells. mouse_pathology.ontology MPATH:267 glandular tumor MPATH:267 Neoplasms derived from glandular epithelial cells. Pathbase: Curation Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3). mouse_pathology.ontology MPATH:268 adenocarcinoma MPATH:268 Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3). Pathbase: Curation A noninvasive abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma. (M-8140/2). mouse_pathology.ontology MPATH:269 adenocarcinoma in situ MPATH:269 A noninvasive abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma. (M-8140/2). Pathbase: Pathology Committee Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process. mouse_pathology.ontology Degenerative joint disease osteoarthrosis MPATH:27 arthrosis MPATH:27 Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process. ISBN:0781727286 Degenerative joint disease Pathbase: Curation osteoarthrosis Pathbase: Curation A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy. mouse_pathology.ontology MPATH:270 adenoma MPATH:270 A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy. Pathbase: Pathology Committee Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0). mouse_pathology.ontology MPATH:271 adenomatous polyposis coli MPATH:271 Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0). Pathbase: Curation Benign epithelial neoplasm of the lung. (M-8140/1) 1.2.1.2 in MMHCC classification. URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass mouse_pathology.ontology Bronchial adenoma Bronchial adenoma, BA adenoma MPATH:272 bronchioloalveolar adenoma MPATH:272 Benign epithelial neoplasm of the lung. (M-8140/1) 1.2.1.2 in MMHCC classification. PMID:15059877 Bronchial adenoma Pathbase: Curation Bronchial adenoma, BA adenoma Pathbase: Curation Malignant epithelial neoplasm of the lung. (M-8250/3) 1.2.3.2, 1.2.3.5 of MMHCC classification. URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass mouse_pathology.ontology Bronchioloalveolar adenocarcinoma Bronchioloalveolar adenocarcinoma, bronchioalveolar carcinoma MPATH:273 bronchioloalveolar carcinoma MPATH:273 Malignant epithelial neoplasm of the lung. (M-8250/3) 1.2.3.2, 1.2.3.5 of MMHCC classification. PMID:15059877 Bronchioloalveolar adenocarcinoma Pathbase: Curation Bronchioloalveolar adenocarcinoma, bronchioalveolar carcinoma Pathbase: Curation An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumor cells. (M-8310/3). mouse_pathology.ontology MPATH:274 clear cell adenocarcinoma MPATH:274 An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumor cells. (M-8310/3). Pathbase: Curation Form of carcinoma of the breast or other organ in which plugs of necrotic malignant cells are present in the ducts. (M -8501/3). mouse_pathology.ontology MPATH:275 comedocarcinoma MPATH:275 Form of carcinoma of the breast or other organ in which plugs of necrotic malignant cells are present in the ducts. (M -8501/3). Pathbase: Pathology Committee Malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/3). mouse_pathology.ontology MPATH:276 cystadenocarcinoma MPATH:276 Malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/3). Pathbase: Curation A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0). mouse_pathology.ontology MPATH:277 cystadenoma MPATH:277 A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0). Pathbase: Pathology Committee Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3). mouse_pathology.ontology Follicular carcinoma MPATH:278 follicular adenocarcinoma MPATH:278 Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3). Pathbase: Curation Follicular carcinoma Pathbase: Curation Adenoma derived from the follicular cells of the thyroid follicles. Follicular, paipillary and solid forms. M- 8330/0. mouse_pathology.ontology MPATH:279 follicular adenoma MPATH:279 Adenoma derived from the follicular cells of the thyroid follicles. Follicular, paipillary and solid forms. M- 8330/0. Pathbase: Curation Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification. mouse_pathology.ontology MPATH:28 Note that in mouse and rats the initial lesions are mostly in the medial layer while in human they occur in the intima. atherosclerosis MPATH:28 Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification. Pathbase: Pathology Committee Adenoma derived from acinar epithelium of the harderian gland. Papillary, cystic, cystic-papillary and acinar forms. mouse_pathology.ontology MPATH:280 Harderian gland adenoma MPATH:280 Adenoma derived from acinar epithelium of the harderian gland. Papillary, cystic, cystic-papillary and acinar forms. Pathbase: Pathology Committee Malignant tumor derived form acinar epithelium of the Harderian gland. mouse_pathology.ontology MPATH:281 Harderian gland carcinoma MPATH:281 Malignant tumor derived form acinar epithelium of the Harderian gland. Pathbase: Pathology Committee Derived from the mammary ductal epithelium and penetrating the stroma (M-8500/3). mouse_pathology.ontology Infiltrating ductal adenocarcinoma duct adenocarcinoma ductal carcinoma MPATH:282 infiltrating duct carcinoma MPATH:282 Derived from the mammary ductal epithelium and penetrating the stroma (M-8500/3). Pathbase: Pathology Committee Infiltrating ductal adenocarcinoma Pathbase: Curation duct adenocarcinoma Pathbase: Curation ductal carcinoma Pathbase: Curation In situ carcinoma of the mammary ductal epithelium. (M- 8500/2). mouse_pathology.ontology Ductal carcinoma in situ intraductal adenocarcinoma, non-infiltrating MPATH:283 Made obsolete by inclusion in MPATH: 486 Ductal intra-epithelial neoplasia intraductal carcinoma true MPATH:283 In situ carcinoma of the mammary ductal epithelium. (M- 8500/2). Pathbase: Curation Ductal carcinoma in situ Pathbase: Curation intraductal adenocarcinoma, non-infiltrating Pathbase: Curation Infiltrating tumor with papillary morphology derived from the breast epithelium (M-8503/3). mouse_pathology.ontology Intraductal papillary adenocarcinoma MPATH:284 intraductal papillary carcinoma MPATH:284 Infiltrating tumor with papillary morphology derived from the breast epithelium (M-8503/3). Pathbase: Curation Intraductal papillary adenocarcinoma Pathbase: Curation Benign papilloma arising from ductal epithelium (M- 8503/0 ). mouse_pathology.ontology Duct adenoma ductal papilloma MPATH:285 intraductal papilloma MPATH:285 Benign papilloma arising from ductal epithelium (M- 8503/0 ). Pathbase: Curation Duct adenoma Pathbase: Curation ductal papilloma Pathbase: Curation Diffuse multiple adenomatous papillomas derived from the ductal epithelium of the breast. (M- 8505/0). mouse_pathology.ontology Diffuse intraductal papillomatosis MPATH:286 intraductal papillomatosis MPATH:286 Diffuse multiple adenomatous papillomas derived from the ductal epithelium of the breast. (M- 8505/0). Pathbase: Curation Diffuse intraductal papillomatosis Pathbase: Curation Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0). mouse_pathology.ontology Adenoma, endocrine pancreas adenomatosis islet (pancreatic) cell tumor benign MPATH:287 islet cell adenoma MPATH:287 Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0). Pathbase: Curation Adenoma, endocrine pancreas Pathbase: Curation adenomatosis Pathbase: Curation islet (pancreatic) cell tumor benign Pathbase: Curation Rare tumor of the islets of Langerhans, most of which produce insulin. (M- 8150/3). mouse_pathology.ontology Adenocarcinoma, endocrine pancreas islet cell tumor, malignant MPATH:288 islet cell carcinoma MPATH:288 Rare tumor of the islets of Langerhans, most of which produce insulin. (M- 8150/3). Pathbase: Pathology Committee Adenocarcinoma, endocrine pancreas Pathbase: Curation islet cell tumor, malignant Pathbase: Curation A form of breast adenocarcinoma derived from lobular cells. (M-8520/3). mouse_pathology.ontology Lobular adenocarcinoma lobular infiltrating carcinoma MPATH:289 lobular carcinoma MPATH:289 A form of breast adenocarcinoma derived from lobular cells. (M-8520/3). Pathbase: Curation Lobular adenocarcinoma Pathbase: Curation lobular infiltrating carcinoma Pathbase: Curation Opacity of the lens. mouse_pathology.ontology MPATH:29 cataract MPATH:29 Opacity of the lens. PMID:9309781 Non-infiltrating form of lobular adenocarcinoma derived from the ductal epithelium. (M-8520/2). mouse_pathology.ontology mammary intra-epithelial neoplasia MPATH:290 lobular carcinoma in situ MPATH:290 Non-infiltrating form of lobular adenocarcinoma derived from the ductal epithelium. (M-8520/2). ISBN:0781727286 mammary intra-epithelial neoplasia Pathbase: Curation Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3). mouse_pathology.ontology Medullary adenocarcinoma MPATH:291 medullary carcinoma MPATH:291 Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3). Pathbase: Pathology Committee Medullary adenocarcinoma Pathbase: Curation Malignant neoplasm derived from a glandular epithelium, eg. Ovary. Consisting of a solid to cystic mass lined with cuboidal pleomorphic epithelial cells producing a mucinous material. (M- 8470/3). mouse_pathology.ontology MPATH:292 mucinous cystadenocarcinoma MPATH:292 Malignant neoplasm derived from a glandular epithelium, eg. Ovary. Consisting of a solid to cystic mass lined with cuboidal pleomorphic epithelial cells producing a mucinous material. (M- 8470/3). Pathbase: Pathology Committee A benign neoplasm derived from glandular epithelium, in which cystic accumulations of mucinous retained secretions are formed. (M-8470/0). mouse_pathology.ontology MPATH:293 mucinous cystadenoma MPATH:293 A benign neoplasm derived from glandular epithelium, in which cystic accumulations of mucinous retained secretions are formed. (M-8470/0). Pathbase: Pathology Committee Tumor originating in myoepithelial cells of exocrine glandular structures; for example mammary gland, salivary gland and preputial/clitoral glands. (M-8982/0). mouse_pathology.ontology myoepithelial adenoma MPATH:294 myoepithelioma MPATH:294 Tumor originating in myoepithelial cells of exocrine glandular structures; for example mammary gland, salivary gland and preputial/clitoral glands. (M-8982/0). Pathbase: Pathology Committee myoepithelial adenoma Pathbase: Curation A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3). mouse_pathology.ontology MPATH:295 papillary adenocarcinoma MPATH:295 A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3). Pathbase: Pathology Committee A benign neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/0). mouse_pathology.ontology MPATH:296 papillary adenoma MPATH:296 A benign neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/0). Pathbase: Pathology Committee A malignant neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/3). mouse_pathology.ontology MPATH:297 papillary cystadenocarcinoma MPATH:297 A malignant neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/3). Pathbase: Pathology Committee A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0). mouse_pathology.ontology MPATH:298 papillary cystadenoma MPATH:298 A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0). Pathbase: Pathology Committee Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1). mouse_pathology.ontology MPATH:299 pinealoma MPATH:299 Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1). Pathbase: Pathology Committee Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies. mouse_pathology.ontology programmed cell death MPATH:3 apoptosis MPATH:3 Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies. Pathbase: Pathology Committee programmed cell death Pathbase: Curation Loss of muscle fibers and elastin in the media of the aorta, with accumulation of mucopolysaccharide. mouse_pathology.ontology Erdheim disease Mucoid medial degeneration media necrosis aortae idiopathica cystica media necrosis of the aorta MPATH:30 cystic medial necrosis MPATH:30 Loss of muscle fibers and elastin in the media of the aorta, with accumulation of mucopolysaccharide. ISBN:0781727286 Erdheim disease Pathbase: Curation Mucoid medial degeneration Pathbase: Curation media necrosis aortae idiopathica cystica Pathbase: Curation media necrosis of the aorta Pathbase: Curation Malignant neoplasms which arise from pineoblasts, the primitive pineal stem cells. (M-9362/3). mouse_pathology.ontology Mixed pineal tumor pineal parenchymal tumor of intermediate differentiation transitional pineal tumor MPATH:300 pineoblastoma MPATH:300 Malignant neoplasms which arise from pineoblasts, the primitive pineal stem cells. (M-9362/3). Pathbase: Pathology Committee Mixed pineal tumor Pathbase: Curation pineal parenchymal tumor of intermediate differentiation Pathbase: Curation transitional pineal tumor Pathbase: Curation A tumor arising in the pineal gland that resembles normal pineal parenchyma. (M-9361/1). mouse_pathology.ontology MPATH:301 pineocytoma MPATH:301 A tumor arising in the pineal gland that resembles normal pineal parenchyma. (M-9361/1). Pathbase: Curation Benign tumor derived from the pituicytes ( glial cells of neurohypophysis) (M-8272/0). mouse_pathology.ontology pituitary adenoma MPATH:302 pituicytoma MPATH:302 Benign tumor derived from the pituicytes ( glial cells of neurohypophysis) (M-8272/0). Pathbase: Curation pituitary adenoma Pathbase: Curation Tumor characterized by extensive spread of a mucin-secreting neoplasm along the peritoneal surfaces (M-8480/6). mouse_pathology.ontology MPATH:303 pseudomyxoma peritonei MPATH:303 Tumor characterized by extensive spread of a mucin-secreting neoplasm along the peritoneal surfaces (M-8480/6). Pathbase: Curation Adenocarcinoma from a serous gland producing and containing serous proteinaceous secretions (M-8441/3). mouse_pathology.ontology MPATH:304 serous adenocarcinoma MPATH:304 Adenocarcinoma from a serous gland producing and containing serous proteinaceous secretions (M-8441/3). Pathbase: Pathology Committee Ovarian cystadenoma composed of cells similar to tubal epithelium (M-8441/0). mouse_pathology.ontology MPATH:305 serous cystadenoma MPATH:305 Ovarian cystadenoma composed of cells similar to tubal epithelium (M-8441/0). Pathbase: Curation Adenocarcinoma of signet ring type arising from exocrine cells of the gastric mucosa or enterocytes of intestinal mucosa. (M-8490/3). mouse_pathology.ontology Signet ring cell adenocarcinoma signet ring cell carcinoma MPATH:306 signet ring cell carcinoma MPATH:306 Adenocarcinoma of signet ring type arising from exocrine cells of the gastric mucosa or enterocytes of intestinal mucosa. (M-8490/3). PMID:12612914 Signet ring cell adenocarcinoma Pathbase: Curation signet ring cell carcinoma Pathbase: Curation Benign neoplasm derived from the calcitonin producing C-cells of the thyroid gland. mouse_pathology.ontology Adenoma, parafollicular cell tumor c-cell benign MPATH:307 thyroid C-cell adenoma MPATH:307 Benign neoplasm derived from the calcitonin producing C-cells of the thyroid gland. Pathbase: Curation Adenoma, parafollicular cell Pathbase: Curation tumor c-cell benign Pathbase: Curation Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3). mouse_pathology.ontology Medullary carcinoma, parafollicular cell tumor c-cell malignant MPATH:308 thyroid C-cell carcinoma MPATH:308 Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3). Pathbase: Curation Medullary carcinoma, parafollicular cell Pathbase: Curation tumor c-cell malignant Pathbase: Curation Germ cell and non-germ cell tumors of the testis and ovary. mouse_pathology.ontology MPATH:309 gonadal tumor MPATH:309 Germ cell and non-germ cell tumors of the testis and ovary. Pathbase: Pathology Committee Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number. mouse_pathology.ontology MPATH:31 emphysema MPATH:31 Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number. ISBN:0781727286 Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells. mouse_pathology.ontology MPATH:310 germ cell tumor MPATH:310 Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells. Pathbase: Pathology Committee Cystic ovarian teratomas with different mature cell types (M-9084/3). mouse_pathology.ontology MPATH:311 dermoid cyst MPATH:311 Cystic ovarian teratomas with different mature cell types (M-9084/3). Pathbase: Curation Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3). mouse_pathology.ontology Seminoma (sensu male) MPATH:312 dysgerminoma MPATH:312 Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3). Pathbase: Curation Seminoma (sensu male) Pathbase: Curation Germ cell derived malignant neoplasm of the testis or ovary, composed of anaplastic cells with indistinct cellular borders and large ovoid, round, or bean-shaped nuclei that may have large nucleoli. (M-9070/3 ). mouse_pathology.ontology MPATH:313 embryonal carcinoma MPATH:313 Germ cell derived malignant neoplasm of the testis or ovary, composed of anaplastic cells with indistinct cellular borders and large ovoid, round, or bean-shaped nuclei that may have large nucleoli. (M-9070/3 ). Pathbase: Curation Germ cell derived tumors resembling parietal or visceral yolk sac endoderm derivatives. Abundant eosinophilic matrix surrounding nests and cords of neoplastic cells. (M-9071-3). mouse_pathology.ontology Yolk sac carcinoma MPATH:314 endodermal sinus tumor MPATH:314 Germ cell derived tumors resembling parietal or visceral yolk sac endoderm derivatives. Abundant eosinophilic matrix surrounding nests and cords of neoplastic cells. (M-9071-3). Pathbase: Pathology Committee Yolk sac carcinoma Pathbase: Curation Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1). mouse_pathology.ontology Gonocytoma MPATH:315 gonadoblastoma MPATH:315 Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1). Pathbase: Curation Gonocytoma Pathbase: Curation Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3). mouse_pathology.ontology Mixed teratoma and seminoma MPATH:316 mixed germ cell tumor MPATH:316 Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3). Pathbase: Curation Mixed teratoma and seminoma Pathbase: Curation Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3). mouse_pathology.ontology Germinoma, malignant dysgerminoma spermatoblastoma spermatocytoma, malignant. MPATH:317 seminoma MPATH:317 Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3). Pathbase: Curation Germinoma, malignant Pathbase: Curation dysgerminoma Pathbase: Curation spermatoblastoma Pathbase: Curation spermatocytoma, malignant. Pathbase: Curation As MPATH:317, but not spermatocytic (M-9061/3). mouse_pathology.ontology MPATH:318 classical seminoma MPATH:318 As MPATH:317, but not spermatocytic (M-9061/3). Pathbase: Curation Neoplasm of the testis usually found within the tubule. Some debate as to whether it is of germ cell origin in contrast to classical seminoma. Three types of cells are identified in spermatocytic seminomas: those with small, intermediate, and large nuclei in humans. (M-9063/3). mouse_pathology.ontology Spermatoma MPATH:319 spermatocytic seminoma MPATH:319 Neoplasm of the testis usually found within the tubule. Some debate as to whether it is of germ cell origin in contrast to classical seminoma. Three types of cells are identified in spermatocytic seminomas: those with small, intermediate, and large nuclei in humans. (M-9063/3). :Walt; H.; Oosterhuis; J.W. and Stevens; L.C. (1993) Int J Androl; 16; 267-271 Spermatoma Pathbase: Curation Increase in the intraocular pressure. mouse_pathology.ontology MPATH:32 glaucoma MPATH:32 Increase in the intraocular pressure. Pathbase: Curation Rare ovarian tumor, regarded as monodermal teratoma, in which thyroid tissue has surpassed the other elements; occasionally associated with hyperthyroidism (M-9090/0). mouse_pathology.ontology MPATH:320 struma ovarii MPATH:320 Rare ovarian tumor, regarded as monodermal teratoma, in which thyroid tissue has surpassed the other elements; occasionally associated with hyperthyroidism (M-9090/0). Pathbase: Curation Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3). mouse_pathology.ontology MPATH:321 teratocarcinoma MPATH:321 Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3). Pathbase: Curation Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1). mouse_pathology.ontology MPATH:322 teratoma MPATH:322 Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1). Pathbase: Pathology Committee Neoplasms derived from the non-germ cell derived tissues of the testis and ovary. mouse_pathology.ontology MPATH:323 gonadal somatic cell tumor MPATH:323 Neoplasms derived from the non-germ cell derived tissues of the testis and ovary. Pathbase: Curation obsolete use Sertoli cell tumor MPATH: 331. mouse_pathology.ontology MPATH:324 androblastoma true MPATH:324 obsolete use Sertoli cell tumor MPATH: 331. Pathbase: Curation obsolete use thecoma MPATH:334. mouse_pathology.ontology MPATH:325 fibrothecoma true MPATH:325 obsolete use thecoma MPATH:334. Pathbase: Curation . Derived from sex cord stromal cells. In male thought to be Sertoli cells. (M- 8620/1). mouse_pathology.ontology Tumor, sex cord stromal, benign, granulosa cell type gynoblastoma (sensu malignant form in ovary) MPATH:326 granulosa cell tumor MPATH:326 . Derived from sex cord stromal cells. In male thought to be Sertoli cells. (M- 8620/1). PMID:9789961 Tumor, sex cord stromal, benign, granulosa cell type Pathbase: Curation gynoblastoma (sensu malignant form in ovary) Pathbase: Curation gynandroblastoma mouse_pathology.ontology MPATH:327 obsolete Use sertoli-leydig cell tumor MPATH 332 gynandroblastoma true MPATH:327 gynandroblastoma Pathbase: Curation Tumor derived from Leydig cells (M-8650/1). mouse_pathology.ontology Interstitial cell tumor, benign Leydig cell adenoma MPATH:328 leydig cell tumor MPATH:328 Tumor derived from Leydig cells (M-8650/1). Mahler M; Sundberg JP ( 1997) Spontaneous Leydig cell tumors in inbred laboratory mice Lab Animal Science 47:148-52 Interstitial cell tumor, benign Pathbase: Curation Leydig cell adenoma Pathbase: Curation Tumor derived from sex cords composed of highly luteinised cells with extensive pale granular cytoplasm. (M- 8610/0). mouse_pathology.ontology Luteoma luteinised granulosa cell tumor, benign. Gonadal sex cord stromal tumor, benign, luteoma type MPATH:329 luteal cell tumor MPATH:329 Tumor derived from sex cords composed of highly luteinised cells with extensive pale granular cytoplasm. (M- 8610/0). Pathbase: Curation Luteoma Pathbase: Curation luteinised granulosa cell tumor, benign. Gonadal sex cord stromal tumor, benign, luteoma type Pathbase: Curation Accumulation of substances within, on the surface of or between cells. mouse_pathology.ontology MPATH:33 intracellular and extracellular accumulation MPATH:33 Accumulation of substances within, on the surface of or between cells. Pathbase: Pathology Committee Tumor consists of a mixture of granulosa, luteal thecal, Sertoli and stromal cells. (M-8590/1). mouse_pathology.ontology MPATH:330 ovarian stromal tumor MPATH:330 Tumor consists of a mixture of granulosa, luteal thecal, Sertoli and stromal cells. (M-8590/1). Pathbase: Curation Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1). mouse_pathology.ontology Androblastoma arrhenoblastoma gonadal stromal tumor sex cord stromal tumor sustentacluar tumor MPATH:331 sertoli cell tumor MPATH:331 Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1). Pathbase: Pathology Committee Androblastoma Pathbase: Curation arrhenoblastoma Pathbase: Curation gonadal stromal tumor Pathbase: Curation sex cord stromal tumor Pathbase: Curation sustentacluar tumor Pathbase: Curation Tumor of the ovary or testis containing granulosa or theca cell elements with a tubular componant of Sertoli cell type and producing simultaneous androgenic and estrogenic effects. (M-8631/0). mouse_pathology.ontology Gynandroblastoma MPATH:332 sertoli-leydig cell tumor MPATH:332 Tumor of the ovary or testis containing granulosa or theca cell elements with a tubular componant of Sertoli cell type and producing simultaneous androgenic and estrogenic effects. (M-8631/0). Pathbase: Pathology Committee Gynandroblastoma Pathbase: Curation sex cord tumor mouse_pathology.ontology MPATH:333 obsolete: Use more specific terms: MPATH: 334, 331, 329, 326 sex cord tumor true MPATH:333 sex cord tumor Pathbase: Curation Derived from sex cord stromal cells, spindle shaped cells arranged in whorls or interlacing bundles. (M- 8600/0). mouse_pathology.ontology Fibrothecoma theca cell tumor MPATH:334 thecoma MPATH:334 Derived from sex cord stromal cells, spindle shaped cells arranged in whorls or interlacing bundles. (M- 8600/0). Pathbase: Curation Fibrothecoma Pathbase: Curation theca cell tumor Pathbase: Curation Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages. mouse_pathology.ontology MPATH:335 hematopoietic/lymphoid malignancies/disorder MPATH:335 Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 leukaemia mouse_pathology.ontology MPATH:336 obsolete folowing reclassification. leukaemia true MPATH:336 leukaemia Pathbase: Curation Leukaemia with at least 50% of nucleated erythroid cells infiltrating haematopoietic tissue. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:337 erythroid leukaemia MPATH:337 Leukaemia with at least 50% of nucleated erythroid cells infiltrating haematopoietic tissue. PMID:12070033 granulocytic leukaemia mouse_pathology.ontology MPATH:338 obsolete following reclassification see: MPATH505 granulocytic leukaemia true MPATH:338 granulocytic leukaemia Pathbase: Curation lymphatic leukaemia mouse_pathology.ontology MPATH:339 lymphatic leukaemia true MPATH:339 lymphatic leukaemia Pathbase: Curation Extracellular deposition of amyloid protein. mouse_pathology.ontology Amyloidosis MPATH:34 Any group of chemically diverse proteins that appears microscopically homogeneous, but is composed of linear non-branching aggregated fibrils aranged in sheets when see under the electron microscope. amyloid deposition MPATH:34 Extracellular deposition of amyloid protein. ISBN:0781727286 Amyloidosis Pathbase: Curation Leukaemia with at least 50% of megakaryocytic cells infiltrating haematopoietic tissue. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:340 megakaryocytic leukaemia MPATH:340 Leukaemia with at least 50% of megakaryocytic cells infiltrating haematopoietic tissue. PMID:12070033 Haematopoietic proliferation with evidence of trilineage dysplasia. Less than 20% should be blasts. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:341 myelodysplastic disorder MPATH:341 Haematopoietic proliferation with evidence of trilineage dysplasia. Less than 20% should be blasts. PMID:12070033 Leukaemias of the myeloid lineage. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology granulocytic leukaemia MPATH:342 myeloid leukaemia MPATH:342 Leukaemias of the myeloid lineage. PMID:12070033 granulocytic leukaemia Pathbase: Curation lymphoma mouse_pathology.ontology MPATH:343 obsolete; divided between subtypes of MPATH516, MPATH535 lymphoma true MPATH:343 lymphoma Pathbase: Curation follicle center cell lymphoma mouse_pathology.ontology MPATH:344 obsolete; see MPATH 522 follicle center cell lymphoma true MPATH:344 follicle center cell lymphoma Pathbase: Curation immunoblastic lymphoma mouse_pathology.ontology MPATH:345 obsolete; see MPATH525 immunoblastic lymphoma true MPATH:345 immunoblastic lymphoma Pathbase: Curation George Gkoutos 2011-03-22T01:12:01Z mouse_pathology.ontology MPATH:346 autoimmune mediated disease MPATH:346 small lymphocytic lymphoma mouse_pathology.ontology MPATH:347 obsolete; see MPATH520 small lymphocytic lymphoma true MPATH:347 small lymphocytic lymphoma Pathbase: Curation thymic lymphoma mouse_pathology.ontology MPATH:348 obsolete thymic lymphoma true MPATH:348 thymic lymphoma Pathbase: Curation mast cell tumor mouse_pathology.ontology MPATH:349 obsolete; see MPATH507 mast cell tumor true MPATH:349 mast cell tumor Pathbase: Curation Intra- or extracellular deposition of bile pigments and their metabolites. mouse_pathology.ontology MPATH:35 bile deposition MPATH:35 Intra- or extracellular deposition of bile pigments and their metabolites. Pathbase: Pathology Committee mastocytoma mouse_pathology.ontology MPATH:350 obsolete. See MPATH507 mastocytoma true MPATH:350 mastocytoma Pathbase: Curation A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1). mouse_pathology.ontology MPATH:351 thymoma MPATH:351 A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1). ISBN:0781727286 Tumors of the liver and biliary apparatus. mouse_pathology.ontology MPATH:352 hepatic tumor MPATH:352 Tumors of the liver and biliary apparatus. Pathbase: Curation Benign neoplasm derived from hepatocytes. (M- 8170/0). mouse_pathology.ontology hepatic adenoma, benign, liver cell tumor, benign hepatoma, benign nodule type A MPATH:353 hepatocellular adenoma MPATH:353 Benign neoplasm derived from hepatocytes. (M- 8170/0). Pathbase: Curation hepatic adenoma, benign, liver cell tumor, benign Pathbase: Curation hepatoma, benign Pathbase: Curation nodule type A Pathbase: Curation Malignant tumor derived from the bile duct epithelium. (M8160/3). mouse_pathology.ontology MPATH:354 cholangiocarcinoma MPATH:354 Malignant tumor derived from the bile duct epithelium. (M8160/3). Pathbase: Pathology Committee Develops from cholangiofibrosis, fibrosis of the biliary ducts and is only potentially malignant. mouse_pathology.ontology MPATH:355 cholangiofibroma MPATH:355 Develops from cholangiofibrosis, fibrosis of the biliary ducts and is only potentially malignant. Pathbase: Curation Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3). mouse_pathology.ontology embryonal hepatoma tumor, mixed, poorly differentiated MPATH:356 hepatoblastoma MPATH:356 Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3). Pathbase: Curation embryonal hepatoma Pathbase: Curation tumor, mixed, poorly differentiated Pathbase: Curation Malignant tumor derived from hepatocytes. (M- 8170/3). mouse_pathology.ontology carcinoma, trabecular carcinoma, trabecular (liver) hepatoma, malignant nodule type B MPATH:357 hepatocellular carcinoma MPATH:357 Malignant tumor derived from hepatocytes. (M- 8170/3). Book: Bannasche; P and Zerban; H. Preneoplastic and neoplastic lesions of the rat iver. In; Pathology of neoplasia and preneoplasia in rodents; P. Bannasch and W. Goessner; Editors. 1997. Schattauer; Stuttgart. p. 18-63 carcinoma, trabecular Pathbase: Curation carcinoma, trabecular (liver) Pathbase: Curation hepatoma, malignant Pathbase: Curation nodule type B Pathbase: Curation Tumors derived from melanocytes. mouse_pathology.ontology MPATH:358 melanocytic tumor MPATH:358 Tumors derived from melanocytes. Pathbase: Pathology Committee Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3). URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/malignant_melanoma#melanoma_table mouse_pathology.ontology melanosarcoma melanosarcoma, malignant melanoma MPATH:359 melanoma MPATH:359 Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3). Book: Klein-Szanto; A.J.; Neoplastic and preneoplastic lesions of the mouse skin; in Pathology of neoplasia and preneoplasia in rodents; P. Bannasch and W. Goessner; Editors. 1997. Schattauer; Stuttgart. p. 1-18 melanosarcoma Pathbase: Curation melanosarcoma, malignant melanoma Pathbase: Curation Intra or extracellular deposition of calcium usually as calcium phosphate. mouse_pathology.ontology MPATH:36 calcium deposition MPATH:36 Intra or extracellular deposition of calcium usually as calcium phosphate. Pathbase: Curation A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2). mouse_pathology.ontology level I melanoma MPATH:360 melanoma in situ MPATH:360 A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2). Pathbase: Pathology Committee level I melanoma Pathbase: Curation Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0). mouse_pathology.ontology mole (sensu melanocytic nevus) MPATH:361 naevus MPATH:361 Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0). Pathbase: Pathology Committee mole (sensu melanocytic nevus) Pathbase: Curation Benign or malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures. (M-9110/3). mouse_pathology.ontology mesonephric adenocarcinoma, wolffian duct carcinoma, mesonephroid tumor MPATH:362 mesonephroma MPATH:362 Benign or malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures. (M-9110/3). Pathbase: Pathology Committee mesonephric adenocarcinoma, wolffian duct carcinoma, mesonephroid tumor Pathbase: Curation Tumor beleived to be derived from mesonephric remnants. (M-8310/3). mouse_pathology.ontology mesonephroid clear cell adenocarcinoma MPATH:363 mesonephric tumor MPATH:363 Tumor beleived to be derived from mesonephric remnants. (M-8310/3). Pathbase: Curation mesonephroid clear cell adenocarcinoma Pathbase: Curation mesothelial tumor mouse_pathology.ontology MPATH:364 obsolete; subsumed into MPATH365 mesothelial tumor true MPATH:364 mesothelial tumor Pathbase: Curation Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3). mouse_pathology.ontology MPATH:365 mesothelioma MPATH:365 Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3). Pathbase: Curation Neoplasms derived from the neuroendocrine system. mouse_pathology.ontology MPATH:366 neuroendocrine tumor MPATH:366 Neoplasms derived from the neuroendocrine system. Pathbase: Curation Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells. Found predominantly in the lung and gut they are capable of secreting a large range of substances and have a number of histological subtypes. May resemble but are distinct from small cell lung carcinoma in the lung. (M-8240/3). mouse_pathology.ontology MPATH:367 carcinoid tumor MPATH:367 Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells. Found predominantly in the lung and gut they are capable of secreting a large range of substances and have a number of histological subtypes. May resemble but are distinct from small cell lung carcinoma in the lung. (M-8240/3). Pathbase: Pathology Committee obsolete. mouse_pathology.ontology MPATH:368 endocrine adenocarcinoma true MPATH:368 obsolete. Pathbase: Curation endocrine adenoma mouse_pathology.ontology MPATH:369 endocrine adenoma true MPATH:369 endocrine adenoma Pathbase: Curation Intracellular deposition of golden or yellow-brown pigment, acid fast and insoluble in lipid solvents. Believed to be a type of lipofuscin. mouse_pathology.ontology MPATH:37 ceroid deposition MPATH:37 Intracellular deposition of golden or yellow-brown pigment, acid fast and insoluble in lipid solvents. Believed to be a type of lipofuscin. Pathbase: Pathology Committee Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3). mouse_pathology.ontology PNET MPATH:370 primitive neurectodermal tumor MPATH:370 Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3). ISBN-13:9783794515530 PNET Pathbase: Curation Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification. URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass mouse_pathology.ontology oat cell carcinoma MPATH:371 see: Meuwissen, R., Linn, S.C., Linnoila, R.I. et al. (2003) Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer cell, 4: 181-189. AND Calbo, J., Meuwissen, R., van Montfort, E. et al. (2005) Genotype-phenotype relationships in a mouse model for human small-cell lung cancer. Cold Spring Harbor symposia on quantitative biology, 70: 225-232. AND Meuwissen, R. and Berns, A. (2005) Mouse models for human lung cancer. Genes & development, 19: 643-664. small cell carcinoma MPATH:371 Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification. PMID:15059877 oat cell carcinoma Pathbase: Curation Small disseminated foci of atypical bronchiolar epithelial hyperplasia. Benign. (M- 8040/1). mouse_pathology.ontology MPATH:372 tumorlet MPATH:372 Small disseminated foci of atypical bronchiolar epithelial hyperplasia. Benign. (M- 8040/1). Pathbase: Pathology Committee Neoplasms derived from neuroepithelial precursors. mouse_pathology.ontology MPATH:373 Renamed from neuroepitheliomatous tumor, to reflect primitive origins of this class of tumor. CNS progenitor tumor MPATH:373 Neoplasms derived from neuroepithelial precursors. Pathbase: Pathology Committee A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors in the olfactory epithelium. (M- 9522/3). mouse_pathology.ontology neuroblastoma, olfactory neuroepithelial carcinoma neuroepithelioma, olfactory MPATH:374 esthesioneuroblastoma MPATH:374 A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors in the olfactory epithelium. (M- 9522/3). Pathbase: Curation neuroblastoma, olfactory Pathbase: Curation neuroepithelial carcinoma Pathbase: Curation neuroepithelioma, olfactory Pathbase: Curation A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0). mouse_pathology.ontology MPATH:375 ganglioneuroma MPATH:375 A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0). Pathbase: Pathology Committee A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3). mouse_pathology.ontology MPATH:376 neuroblastoma MPATH:376 A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3). ISBN-13:9783794515530 A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3). mouse_pathology.ontology MPATH:377 pheochromocytoma MPATH:377 A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3). Pathbase: Pathology Committee Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3). mouse_pathology.ontology MPATH:378 retinoblastoma MPATH:378 Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3). Pathbase: Curation Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) . mouse_pathology.ontology MPATH:379 odontogenic tumor MPATH:379 Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) . Pathbase: Pathology Committee Intra and extracellular deposition of copper and copper containing proteins. mouse_pathology.ontology MPATH:38 copper deposition MPATH:38 Intra and extracellular deposition of copper and copper containing proteins. Pathbase: Curation A tumor consisting of proliferating strands and clumps of odontogenic epithelium in a highly cellular fibroblastic stroma resembling the dental papilla of developing teeth. The epithelial component are composed of peripheral cuboidal or cylindrical cells enclosing scant stellate cells. (M-9330/0). mouse_pathology.ontology MPATH:380 ameloblastic fibroma MPATH:380 A tumor consisting of proliferating strands and clumps of odontogenic epithelium in a highly cellular fibroblastic stroma resembling the dental papilla of developing teeth. The epithelial component are composed of peripheral cuboidal or cylindrical cells enclosing scant stellate cells. (M-9330/0). Pathbase: Pathology Committee Benign odontogenic epithelial neoplasm that histologically mimics the embryonic enamel organ but does not differentiate to the point of forming dental hard tissue. Histologically dominated by epithelial cells in a scant fibroblastic stroma. (M-9310/0). mouse_pathology.ontology MPATH:381 ameloblastoma MPATH:381 Benign odontogenic epithelial neoplasm that histologically mimics the embryonic enamel organ but does not differentiate to the point of forming dental hard tissue. Histologically dominated by epithelial cells in a scant fibroblastic stroma. (M-9310/0). Pathbase: Pathology Committee Benign neoplasm derived from pluripotential mesenchymal cells or cementoblasts. Well demarcated tumor occurring exclusively in the jaw containing spindle cells which undergo transformation to cuboidal cementoblasts forming multiple cementicle like bodies. ( M-9274/0). mouse_pathology.ontology ossifying fibroma, cemento-ossifying fibroma MPATH:382 cementifying fibroma MPATH:382 Benign neoplasm derived from pluripotential mesenchymal cells or cementoblasts. Well demarcated tumor occurring exclusively in the jaw containing spindle cells which undergo transformation to cuboidal cementoblasts forming multiple cementicle like bodies. ( M-9274/0). Pathbase: Curation ossifying fibroma, cemento-ossifying fibroma Pathbase: Curation A neoplasm arising from the periodontal ligament (M-9273/0). mouse_pathology.ontology True cementoma MPATH:383 cementoblastoma MPATH:383 A neoplasm arising from the periodontal ligament (M-9273/0). Pathbase: Curation True cementoma Pathbase: Curation Reactive fibro-osseous lesion derived from odotongenic cells in the periodontal ligament (M-9272/0). mouse_pathology.ontology MPATH:384 cementoma MPATH:384 Reactive fibro-osseous lesion derived from odotongenic cells in the periodontal ligament (M-9272/0). Pathbase: Curation Similar lesion to ameloblastic fibroma (MPATH380) , but also showing inductive changes that lead to the formation of dentine (M-9271/0). mouse_pathology.ontology ameloblastic fibrodentinoma MPATH:385 dentinoma MPATH:385 Similar lesion to ameloblastic fibroma (MPATH380) , but also showing inductive changes that lead to the formation of dentine (M-9271/0). Pathbase: Curation ameloblastic fibrodentinoma Pathbase: Curation odontogenic tumor mouse_pathology.ontology MPATH:386 redundant odontogenic tumor true MPATH:386 odontogenic tumor Pathbase: Curation Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0). mouse_pathology.ontology MPATH:387 odontoma MPATH:387 Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0). ISBN:0781727286 Neoplasms of bone and cartilage. mouse_pathology.ontology MPATH:388 osseous and chondromatous tumor MPATH:388 Neoplasms of bone and cartilage. Pathbase: Curation A benign or malignant neoplasm occuring in the epiphyses of long bones, consisting of highly cellular tissue resembling embryonic cartilage. (M-9230/0, /3). mouse_pathology.ontology MPATH:389 chondroblastoma MPATH:389 A benign or malignant neoplasm occuring in the epiphyses of long bones, consisting of highly cellular tissue resembling embryonic cartilage. (M-9230/0, /3). Pathbase: Pathology Committee Intracellular deposition of glycogen. mouse_pathology.ontology MPATH:39 glycogen deposition MPATH:39 Intracellular deposition of glycogen. Pathbase: Curation chondroblastoma, malignant mouse_pathology.ontology MPATH:390 Subsumed into MPATH:389 chondroblastoma, malignant true MPATH:390 chondroblastoma, malignant Pathbase: Curation A benign neoplasm derived from mesodermal cells that form cartilage composed of well differentiated hyaline cartilage (M-9220/0). mouse_pathology.ontology MPATH:391 chondroma MPATH:391 A benign neoplasm derived from mesodermal cells that form cartilage composed of well differentiated hyaline cartilage (M-9220/0). Pathbase: Curation Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3). mouse_pathology.ontology MPATH:392 chondrosarcoma MPATH:392 Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3). Pathbase: Pathology Committee Generally benign osteogenic neoplasm of unknown aetiology. Aggressive form may be confused with osteosarcoma. NOT a syn for osteofibroma. (M-9200/0). mouse_pathology.ontology giant osteoid osteoma, benign osteoblastoma MPATH:393 osteoblastoma MPATH:393 Generally benign osteogenic neoplasm of unknown aetiology. Aggressive form may be confused with osteosarcoma. NOT a syn for osteofibroma. (M-9200/0). Pathbase: Pathology Committee giant osteoid osteoma, benign osteoblastoma Pathbase: Curation Benign bone tumor characterized by hyaline cartilage capped bony growths that project from the surface of the affected bone. (M-9210/0). mouse_pathology.ontology cartilaginous exostosis MPATH:394 osteochondroma MPATH:394 Benign bone tumor characterized by hyaline cartilage capped bony growths that project from the surface of the affected bone. (M-9210/0). Pathbase: Pathology Committee cartilaginous exostosis Pathbase: Curation Benign neoplasm derived from pluripotential mesenchymal stem cells or osteoblasts composed of mature nbone trabelculae seperated by a stroma of spindle cells. (M- 9262/0). mouse_pathology.ontology MPATH:395 osteofibroma MPATH:395 Benign neoplasm derived from pluripotential mesenchymal stem cells or osteoblasts composed of mature nbone trabelculae seperated by a stroma of spindle cells. (M- 9262/0). Pathbase: Curation Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0). mouse_pathology.ontology cancellous osteoma compact osteoma juxtacortical osteoma medullary osteoma osteoid osteoma spongious osteoma trabecular osteoma MPATH:396 osteoma MPATH:396 Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0). Book: Luz; A and Gessner; W. ; Neoplastic bone lesions of the mouse; in Pathology of neoplasia and preneoplasia in rodents; P. Bannasch and W. Goessner; Editors. 1997. Schattauer; Stuttgart. p. 142-154 cancellous osteoma Pathbase: Curation compact osteoma Pathbase: Curation juxtacortical osteoma Pathbase: Curation medullary osteoma Pathbase: Curation osteoid osteoma Pathbase: Curation spongious osteoma Pathbase: Curation trabecular osteoma Pathbase: Curation Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3). mouse_pathology.ontology osteogenic sarcoma MPATH:397 osteosarcoma MPATH:397 Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3). Pathbase: Curation osteogenic sarcoma Pathbase: Curation Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma. mouse_pathology.ontology MPATH:398 paragangliomas and glomus tumor MPATH:398 Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma. Pathbase: Curation Paraganglioma arising in the CHIEF cells of the aortic body (M-8691/1). mouse_pathology.ontology aortic body paraganglioma MPATH:399 aortic body tumor MPATH:399 Paraganglioma arising in the CHIEF cells of the aortic body (M-8691/1). Pathbase: Curation aortic body paraganglioma Pathbase: Curation Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3. mouse_pathology.ontology MPATH:4 necrosis MPATH:4 Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3. ISBN:0781727286 Intracellular deposition of eosinophilic material. mouse_pathology.ontology Hyaline degeneration, Eosinophilic cytoplasmic change MPATH:40 hyalinosis MPATH:40 Intracellular deposition of eosinophilic material. PMID:11794381 Hyaline degeneration, Eosinophilic cytoplasmic change Pathbase: Curation Paraganglioma arising in the CHIEF cells of the carotid body (M-8692/1). mouse_pathology.ontology carotid body paraganglioma MPATH:400 carotid body tumor MPATH:400 Paraganglioma arising in the CHIEF cells of the carotid body (M-8692/1). Pathbase: Pathology Committee carotid body paraganglioma Pathbase: Curation A glomus tumor arising from the chief cells of the paraganglia ( neurectodermal derivatives) , or glomus bodies, located within the wall (adventitia) of the jugular bulb. (8690/1). mouse_pathology.ontology MPATH:401 glomus jugulare tumor MPATH:401 A glomus tumor arising from the chief cells of the paraganglia ( neurectodermal derivatives) , or glomus bodies, located within the wall (adventitia) of the jugular bulb. (8690/1). Pathbase: Curation glomus tumor mouse_pathology.ontology MPATH:402 obsolete; use paraganglioma M-8711/0) or specific example terms, MPATH399-401. glomus tumor true MPATH:402 glomus tumor Pathbase: Curation A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0). mouse_pathology.ontology chemodectomas glomus tumor non-chromaffin paragangliomas MPATH:403 paraganglioma MPATH:403 A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0). Pathbase: Curation chemodectomas Pathbase: Curation glomus tumor Pathbase: Curation non-chromaffin paragangliomas Pathbase: Curation Neoplasms of the soft and connective tissues. mouse_pathology.ontology MPATH:404 soft tissue tumor MPATH:404 Neoplasms of the soft and connective tissues. Pathbase: Curation Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3). mouse_pathology.ontology MPATH:405 chordoma MPATH:405 Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3). Pathbase: Curation Highly recurrent, infiltrative skin tumors of intermediate malignancy derived from fibroblasts/fibrocytes. Human condition dermatofibrosarcoma protruberans (M-8832/3). mouse_pathology.ontology MPATH:406 dermatofibrosarcoma MPATH:406 Highly recurrent, infiltrative skin tumors of intermediate malignancy derived from fibroblasts/fibrocytes. Human condition dermatofibrosarcoma protruberans (M-8832/3). Pathbase: Curation Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0). mouse_pathology.ontology MPATH:407 "Soft tissue" qualifier removed by Pathology Panel to increase scope of term. fibroma MPATH:407 Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0). Pathbase: Pathology Committee Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3). fibrosarcoma mouse_pathology.ontology MPATH:408 soft tissue fibrosarcoma MPATH:408 Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3). Pathbase: Pathology Committee Benign or maligant tumor derived from pluripotential mesenchymal stem cells showing fibrous and histiocytic differentiation (M-8830/0). mouse_pathology.ontology MPATH:409 fibrous histiocytoma MPATH:409 Benign or maligant tumor derived from pluripotential mesenchymal stem cells showing fibrous and histiocytic differentiation (M-8830/0). Pathbase: Curation Extra- or intra-cellular deposition of iron, iron containing proteins or hemosiderin. mouse_pathology.ontology MPATH:41 iron deposition MPATH:41 Extra- or intra-cellular deposition of iron, iron containing proteins or hemosiderin. Pathbase: Curation Malignant or benign tumor of pluripotential mesenchymal stem cells giving rise to large multinucleated cells (M- 9251/1). mouse_pathology.ontology giant cell fibrous histiocytoma MPATH:410 giant cell tumor of soft tissue MPATH:410 Malignant or benign tumor of pluripotential mesenchymal stem cells giving rise to large multinucleated cells (M- 9251/1). Pathbase: Pathology Committee giant cell fibrous histiocytoma Pathbase: Curation granular cell tumor/alveolar sarcoma mouse_pathology.ontology MPATH:411 obsolete. Use specific terms MPATH: 412 or MPATH: 413 granular cell tumor/alveolar sarcoma true MPATH:411 granular cell tumor/alveolar sarcoma Pathbase: Curation Malignant tumor of unknown origin though probably myogenic due to expression of MyoD and other myogenic lineage markers. Consists of grouped polygonal tumor cells with granular eosinophilic cytoplasm arranged in an organ-like configuration separated by thin fibrovascular septa. Central areas within these nests of cells become necrotic, and the loss of architecture produces an alveolar appearance. (M-9581/3). mouse_pathology.ontology MPATH:412 alveolar soft part sarcoma MPATH:412 Malignant tumor of unknown origin though probably myogenic due to expression of MyoD and other myogenic lineage markers. Consists of grouped polygonal tumor cells with granular eosinophilic cytoplasm arranged in an organ-like configuration separated by thin fibrovascular septa. Central areas within these nests of cells become necrotic, and the loss of architecture produces an alveolar appearance. (M-9581/3). Pathbase: Pathology Committee Large polygonal or round cell tumors with abundant acidophilic cytoplasm containing PAS positive granules. Found especially in the uterine cervix. Aetiology unknown. (M-9580/0). mouse_pathology.ontology myoblastoma MPATH:413 granular cell tumor MPATH:413 Large polygonal or round cell tumors with abundant acidophilic cytoplasm containing PAS positive granules. Found especially in the uterine cervix. Aetiology unknown. (M-9580/0). Pathbase: Pathology Committee myoblastoma Pathbase: Curation histiocytic sarcoma mouse_pathology.ontology MPATH:414 redundant use MPATH506 histiocytic sarcoma true MPATH:414 histiocytic sarcoma Pathbase: Curation Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation. mouse_pathology.ontology MPATH:415 lipomatous tumor MPATH:415 Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation. Pathbase: Curation Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0). mouse_pathology.ontology MPATH:416 angiomyolipoma MPATH:416 Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0). Pathbase: Pathology Committee Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0). mouse_pathology.ontology MPATH:417 lipoma MPATH:417 Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0). Pathbase: Pathology Committee Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. (M-8850/3). mouse_pathology.ontology MPATH:418 liposarcoma MPATH:418 Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. (M-8850/3). Pathbase: Pathology Committee Neoplasms of the lymphatic vessels. mouse_pathology.ontology MPATH:419 lymphatic vessel tumor MPATH:419 Neoplasms of the lymphatic vessels. Pathbase: Curation Extra or intracellular deposition of lipid. mouse_pathology.ontology MPATH:42 lipid deposition MPATH:42 Extra or intracellular deposition of lipid. Pathbase: Curation Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0). Hygroma mouse_pathology.ontology MPATH:420 lymphangioma MPATH:420 Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0). ISBN:0781727286 Hygroma ISBN:0-19-261976-4 Characterized by benign peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (M- 9174/1). mouse_pathology.ontology Lymphangioleiomyomatosis. MPATH:421 lymphangiomyomatosis MPATH:421 Characterized by benign peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (M- 9174/1). Pathbase: Curation Lymphangioleiomyomatosis. Pathbase: Curation A malignant neoplasm derived from vascular tissue in which the neoplastic cells originate from the endothelial cells of lymphatic vessels. (M-9170/3). mouse_pathology.ontology MPATH:422 lymphangiosarcoma MPATH:422 A malignant neoplasm derived from vascular tissue in which the neoplastic cells originate from the endothelial cells of lymphatic vessels. (M-9170/3). Pathbase: Curation Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation. mouse_pathology.ontology MPATH:423 myomatous tumor MPATH:423 Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation. Pathbase: Curation Benign leiomyoma that invades vascular spaces. (M-8890/1). mouse_pathology.ontology MPATH:424 intravascular leiomyomatosis MPATH:424 Benign leiomyoma that invades vascular spaces. (M-8890/1). Pathbase: Curation Benign neoplasm derived from smooth muscle cells. (M-8890/0). mouse_pathology.ontology MPATH:425 leiomyoma MPATH:425 Benign neoplasm derived from smooth muscle cells. (M-8890/0). Pathbase: Curation Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3). mouse_pathology.ontology MPATH:426 leiomyosarcoma MPATH:426 Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3). Pathbase: Curation myoblastoma mouse_pathology.ontology MPATH:427 obsolete. Syn of granular cell tumor. MPATH 413 myoblastoma true MPATH:427 myoblastoma Pathbase: Curation Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3). mouse_pathology.ontology MPATH:428 rhabdomyosarcoma MPATH:428 Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3). Pathbase: Curation Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix. mouse_pathology.ontology MPATH:429 myxomatous tumor MPATH:429 Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix. Pathbase: Curation Intracellular deposition of brown pigment granules probably representing lipid-containing residues of lysosomal digestion. Often age related. mouse_pathology.ontology MPATH:43 lipofuscin deposition MPATH:43 Intracellular deposition of brown pigment granules probably representing lipid-containing residues of lysosomal digestion. Often age related. Pathbase: Pathology Committee Angiomyxoma is a poorly circumscribed, slowly growing lesion composed of spindle-shaped and stellate cells evenly distributed in an abundant myxoid matrix. The lesion contains numerous vessels, often showing some hyalinization of their walls, and occasionally surrounded by a few smooth muscle cells. Immunohistochemically, tumor cells may express desmin and/ or smooth muscle actin (M-8841/1). mouse_pathology.ontology MPATH:430 angiomyxoma MPATH:430 Angiomyxoma is a poorly circumscribed, slowly growing lesion composed of spindle-shaped and stellate cells evenly distributed in an abundant myxoid matrix. The lesion contains numerous vessels, often showing some hyalinization of their walls, and occasionally surrounded by a few smooth muscle cells. Immunohistochemically, tumor cells may express desmin and/ or smooth muscle actin (M-8841/1). Pathbase: Curation A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0). mouse_pathology.ontology MPATH:431 myxoma MPATH:431 A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0). Pathbase: Pathology Committee A malignant neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. (M-8840/3). mouse_pathology.ontology MPATH:432 myxosarcoma MPATH:432 A malignant neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. (M-8840/3). Pathbase: Curation Neoplasms of the nerve sheath. mouse_pathology.ontology MPATH:433 nerve sheath tumor MPATH:433 Neoplasms of the nerve sheath. Pathbase: Pathology Committee neurilemmoma mouse_pathology.ontology MPATH:434 obsolete. Use schwannoma MPATH438 neurilemmoma true MPATH:434 neurilemmoma Pathbase: Curation Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0). mouse_pathology.ontology MPATH:435 neurofibroma MPATH:435 Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0). ISBN-13:9783794515530 Systemic manifestation of MPATH:435 ( M-9540/1). mouse_pathology.ontology MPATH:436 neurofibromatosis MPATH:436 Systemic manifestation of MPATH:435 ( M-9540/1). Pathbase: Curation Malignant neoplasm derived from Schwann cells. (M-9540/3). mouse_pathology.ontology malignant peripheral nerve sheath tumor MPATH:437 neurofibrosarcoma MPATH:437 Malignant neoplasm derived from Schwann cells. (M-9540/3). ISBN-13:9783794515530 malignant peripheral nerve sheath tumor Pathbase: Curation May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0). mouse_pathology.ontology neurilemoma neurinoma, benign MPATH:438 schwannoma MPATH:438 May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0). ISBN-13:9783794515530 neurilemoma Pathbase: Curation neurinoma, benign Pathbase: Curation Neoplasms of synovial origin. mouse_pathology.ontology MPATH:439 synovial-like tumor MPATH:439 Neoplasms of synovial origin. Pathbase: Curation Intra or extracellular deposition of melanin. mouse_pathology.ontology MPATH:44 melanin deposition MPATH:44 Intra or extracellular deposition of melanin. Pathbase: Pathology Committee Malignant neoplasm occurring in close association with tendon sheaths and joint capsules. Biphasic in humans , showing a mixed spindle cell and epithelioid like morphology; this is not seen in rodents to date. (M-9040/3). mouse_pathology.ontology Synovial cell sarcoma MPATH:440 synovial sarcoma MPATH:440 Malignant neoplasm occurring in close association with tendon sheaths and joint capsules. Biphasic in humans , showing a mixed spindle cell and epithelioid like morphology; this is not seen in rodents to date. (M-9040/3). Pathbase: Pathology Committee Synovial cell sarcoma Pathbase: Curation synovioma mouse_pathology.ontology MPATH:441 Obsolete. Use MPATH:440 synovioma true MPATH:441 synovioma Pathbase: Curation Neoplasms of stratified squamous epithelial cells. mouse_pathology.ontology MPATH:442 squamous cell tumor MPATH:442 Neoplasms of stratified squamous epithelial cells. Pathbase: Pathology Committee A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded. (M-8053/0). mouse_pathology.ontology endophytic papilloma invaginated papilloma MPATH:443 inverted squamous papilloma MPATH:443 A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded. (M-8053/0). Pathbase: Pathology Committee endophytic papilloma Pathbase: Curation invaginated papilloma Pathbase: Curation Skin type is thought to arise from follicular epithelium of hair follicles; found in other epithelia. Composed of multiple cup shaped cavities filled with lamellated concentrically arranged or homogeneous cornified masses. mouse_pathology.ontology epithelioma, intracutaneous, cornifying MPATH:444 keratoacanthoma MPATH:444 Skin type is thought to arise from follicular epithelium of hair follicles; found in other epithelia. Composed of multiple cup shaped cavities filled with lamellated concentrically arranged or homogeneous cornified masses. Pathbase: Pathology Committee epithelioma, intracutaneous, cornifying Pathbase: Curation A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0). mouse_pathology.ontology MPATH:445 papilloma MPATH:445 A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0). Pathbase: Pathology Committee Malignant tumor derived from stratified squamous cells. (M-8070/3). mouse_pathology.ontology carcinoma, epidermoid ( sensu epidermal derived tumors) MPATH:446 squamous cell carcinoma MPATH:446 Malignant tumor derived from stratified squamous cells. (M-8070/3). Pathbase: Pathology Committee carcinoma, epidermoid ( sensu epidermal derived tumors) Pathbase: Curation Pre-neoplastic intraepithelial lesion of squamous cells (M-8070/2). mouse_pathology.ontology IENIII severe intra-epithelial neoplasia MPATH:447 squamous cell carcinoma in situ MPATH:447 Pre-neoplastic intraepithelial lesion of squamous cells (M-8070/2). Pathbase: Pathology Committee IENIII Pathbase: Curation severe intra-epithelial neoplasia Pathbase: Curation A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic squamous epithelial cells. mouse_pathology.ontology Exophytic papilloma MPATH:448 squamous cell papilloma MPATH:448 A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic squamous epithelial cells. Pathbase: Pathology Committee Exophytic papilloma Pathbase: Curation A well-differentiated papillary squamous cell carcinoma. (M-8051/3). mouse_pathology.ontology MPATH:449 verrucous carcinoma MPATH:449 A well-differentiated papillary squamous cell carcinoma. (M-8051/3). Pathbase: Curation Non-specified intra or extracellular deposition of protein. mouse_pathology.ontology MPATH:45 protein deposition MPATH:45 Non-specified intra or extracellular deposition of protein. Pathbase: Curation Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix. mouse_pathology.ontology MPATH:450 transitional cell tumor MPATH:450 Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix. Pathbase: Pathology Committee Malignant neoplasm of transitional cells (M-8120/3). mouse_pathology.ontology MPATH:451 transitional cell carcinoma MPATH:451 Malignant neoplasm of transitional cells (M-8120/3). Pathbase: Curation Pre-malignant intra-epithelial neoplasm of transitional cells (M-8120/2). mouse_pathology.ontology severe intra-epithelial neoplasia MPATH:452 transitional cell carcinoma in situ MPATH:452 Pre-malignant intra-epithelial neoplasm of transitional cells (M-8120/2). Pathbase: Pathology Committee severe intra-epithelial neoplasia Pathbase: Curation Pre-malignant lesion of transitional cells, papillomatous form ( M- 8120/1). mouse_pathology.ontology MPATH:453 transitional cell papilloma MPATH:453 Pre-malignant lesion of transitional cells, papillomatous form ( M- 8120/1). Pathbase: Pathology Committee Tumors derived directly from trophoblastic tissue or differentiated from germ cell tumor origins. mouse_pathology.ontology MPATH:454 trophoblastic tumor MPATH:454 Tumors derived directly from trophoblastic tissue or differentiated from germ cell tumor origins. Pathbase: Curation Tumor derived from malignant trophoblastic cells. May be found in the uterus, ovary and testis. May also be derived from teratomas and teratocarcinomas in males. (M-9100/3). mouse_pathology.ontology Chorioepithelioma, malignant. MPATH:455 choriocarcinoma MPATH:455 Tumor derived from malignant trophoblastic cells. May be found in the uterus, ovary and testis. May also be derived from teratomas and teratocarcinomas in males. (M-9100/3). Pathbase: Pathology Committee Chorioepithelioma, malignant. Pathbase: Curation Vesicular or cystic tumor with hydropic villi resulting from the proliferation of trophoblast in the absence ( complete) or the presence ( partial) of an embryo. Most complete moles are homozygous androgenetic XX 46.(M-9100/0). mouse_pathology.ontology cystic mole gestational trophoblastic disease MPATH:456 hydatidiform mole MPATH:456 Vesicular or cystic tumor with hydropic villi resulting from the proliferation of trophoblast in the absence ( complete) or the presence ( partial) of an embryo. Most complete moles are homozygous androgenetic XX 46.(M-9100/0). Pathbase: Curation cystic mole Pathbase: Curation gestational trophoblastic disease Pathbase: Curation Neoplastic proliferation of intermediate trophoblasts that invades the myometrium at the placental site after a pregnancy. (M-9104/1). mouse_pathology.ontology MPATH:457 placental site trophoblastic tumor MPATH:457 Neoplastic proliferation of intermediate trophoblasts that invades the myometrium at the placental site after a pregnancy. (M-9104/1). Pathbase: Pathology Committee No pathological entity observable. mouse_pathology.ontology MPATH:458 normal MPATH:458 No pathological entity observable. Pathbase: Pathology Committee obsolete mouse_pathology.ontology MPATH:459 obsolete true MPATH:459 obsolete Pathbase: Pathology Committee Extracellular deposition of uric acid crystals. mouse_pathology.ontology MPATH:46 uric acid deposition MPATH:46 Extracellular deposition of uric acid crystals. Pathbase: Curation Defect in the structure or function of the nuclear membrane or matrix or other component. mouse_pathology.ontology MPATH:460 nuclear defect MPATH:460 Defect in the structure or function of the nuclear membrane or matrix or other component. Pathbase: Curation Proliferation of lens epithelium and capsule leading to fibrous metaplasia and anterior subcapsular cataract ( ASC) . Possible developmental origin. mouse_pathology.ontology MPATH:461 cataract; capsular-epithelial MPATH:461 Proliferation of lens epithelium and capsule leading to fibrous metaplasia and anterior subcapsular cataract ( ASC) . Possible developmental origin. ISBN:08493086 4X Nuclear cataract of developmental origin with tendency to progress with age and involve the cortex and capsule. mouse_pathology.ontology MPATH:462 cataract; nuclear and cortical MPATH:462 Nuclear cataract of developmental origin with tendency to progress with age and involve the cortex and capsule. ISBN:08493086 4X Of developmental origins; nucleus and cortex become completely liquefied in post-natal life. mouse_pathology.ontology MPATH:463 cataract; cortical liquefactive MPATH:463 Of developmental origins; nucleus and cortex become completely liquefied in post-natal life. ISBN:08493086 4X Involves capsular rupture usually of the posterior lens capsule, close to birth or in the first few weeks postpartum. Cortical material spills into the vitreous humor and may be disseminated through the eye. mouse_pathology.ontology MPATH:464 cataract; lens extrusion MPATH:464 Involves capsular rupture usually of the posterior lens capsule, close to birth or in the first few weeks postpartum. Cortical material spills into the vitreous humor and may be disseminated through the eye. ISBN:08493086 4X Consequent on developmental abnormalities in the trabecular network and Schlemm`s canal in the angle. mouse_pathology.ontology MPATH:465 glaucoma developmental MPATH:465 Consequent on developmental abnormalities in the trabecular network and Schlemm`s canal in the angle. ISBN:08493086 4X Failure of drainage of the eye for unknown reasons. mouse_pathology.ontology MPATH:466 glaucoma; open angle MPATH:466 Failure of drainage of the eye for unknown reasons. ISBN:08493086 4X Develops when the angle caused by the iris and cornea closes. May occur because of anatomically narrow angles or adhesions. mouse_pathology.ontology MPATH:467 glaucoma; angle closure MPATH:467 Develops when the angle caused by the iris and cornea closes. May occur because of anatomically narrow angles or adhesions. ISBN:08493086 4X Formation of extracellular (sensu pancreas) non-epithelial bounded spaces containing accumulated products or substances. mouse_pathology.ontology MPATH:468 pseudocyst MPATH:468 Formation of extracellular (sensu pancreas) non-epithelial bounded spaces containing accumulated products or substances. Pathbase: Pathology Committee Any aberration of the normal symmetrical organisation of the body pattern. mouse_pathology.ontology MPATH:469 symmetry defect MPATH:469 Any aberration of the normal symmetrical organisation of the body pattern. Pathbase: Curation Loss or dispersion of specific intra- and extracellular substances. mouse_pathology.ontology MPATH:47 intracellular and extracellular depletion MPATH:47 Loss or dispersion of specific intra- and extracellular substances. Pathbase: Pathology Committee Left/Right (mediolateral) axis aberration of the normal symmetrical organisation of the body pattern. mouse_pathology.ontology MPATH:470 For example as seen in the mutation <situs inversus>. left/right axis defect MPATH:470 Left/Right (mediolateral) axis aberration of the normal symmetrical organisation of the body pattern. Pathbase: Pathology Committee Anteroposterior aberration of the normal symmetrical organisation of the body pattern. mouse_pathology.ontology MPATH:471 anterior/posterior axis defect MPATH:471 Anteroposterior aberration of the normal symmetrical organisation of the body pattern. Pathbase: Curation Dorsoventral aberration of the normal symmetrical organisation of the body pattern. mouse_pathology.ontology MPATH:472 dorsal/ventral axis defect MPATH:472 Dorsoventral aberration of the normal symmetrical organisation of the body pattern. Pathbase: Curation Developmental dysplasia showing epithelial cell bounded cavities. mouse_pathology.ontology MPATH:473 developmental cystic dysplasia MPATH:473 Developmental dysplasia showing epithelial cell bounded cavities. Pathbase: Pathology Committee Dilation of a tubular structure. mouse_pathology.ontology MPATH:474 Often associated with an obstruction. ectasia MPATH:474 Dilation of a tubular structure. Pathbase: Pathology Committee Dilation of a ductal structure. mouse_pathology.ontology MPATH:475 ductal ectasia MPATH:475 Dilation of a ductal structure. Pathbase: Curation A lesion formed by a dilated capillary or terminal artery. mouse_pathology.ontology MPATH:476 telangiectasia MPATH:476 A lesion formed by a dilated capillary or terminal artery. Pathbase: Curation Similar to hamartoma, including the mass lesion requirement, but unlike hamartoma, includes heterotopic tissue of an adult or embryonic nature ( topographical and developmental anomaly). mouse_pathology.ontology Choristoblastoma MPATH:477 choristoma MPATH:477 Similar to hamartoma, including the mass lesion requirement, but unlike hamartoma, includes heterotopic tissue of an adult or embryonic nature ( topographical and developmental anomaly). ISBN:0781727286 Choristoblastoma Pathbase: Curation Abnormality in developmental angiogenesis. mouse_pathology.ontology MPATH:478 angiogenesis defect MPATH:478 Abnormality in developmental angiogenesis. Pathbase: Pathology Committee Defect in formation of blood vessels by vasculogenesis, proliferation or recruitment of endothelial cells. mouse_pathology.ontology MPATH:479 vasculogenesis defect MPATH:479 Defect in formation of blood vessels by vasculogenesis, proliferation or recruitment of endothelial cells. Pathbase: Pathology Committee Process of loss of calcium from normally calcified tissue, usually bone. mouse_pathology.ontology MPATH:48 decalcification MPATH:48 Process of loss of calcium from normally calcified tissue, usually bone. Pathbase: Curation Any defect in the formation, architecture, cellular composition or function of the maternal decidua. mouse_pathology.ontology MPATH:480 decidual defect MPATH:480 Any defect in the formation, architecture, cellular composition or function of the maternal decidua. Pathbase: Curation Lesions likely to result in progression to frank tumors, which may be classified as pre-neoplastic or pre-cancerous. mouse_pathology.ontology MPATH:481 Obsolete; replaced by potentially pre-cancerous lesions (MPATH 556) as many are actually neoplastic but do not progress to cancer. pre-neoplastic lesions true MPATH:481 Lesions likely to result in progression to frank tumors, which may be classified as pre-neoplastic or pre-cancerous. Journal: Ward; J.M. ( 2002) J Toxicol. Pathol. 15; 123-128 Localised hyperplastic lesion. Polyclonal lesions are probably benign but clonal lesions may progress to malignancy. mouse_pathology.ontology MPATH:482 focal hyperplasia MPATH:482 Localised hyperplastic lesion. Polyclonal lesions are probably benign but clonal lesions may progress to malignancy. Pathbase: Pathology Committee Presence of localised areas within for example adenomas showing characteristics of neoplastic (tumor) progression, eg focal carcinoma. mouse_pathology.ontology MPATH:483 Considered to be too vague to be useful. atypical hyperplasia true MPATH:483 Presence of localised areas within for example adenomas showing characteristics of neoplastic (tumor) progression, eg focal carcinoma. Pathbase: Pathology Committee Expansion of small hyperplastic lesions to become macroscopically nodules, compressing adjacent cells. mouse_pathology.ontology hyperplastic nodules nodular hyperplasia MPATH:484 hyperplastic nodule MPATH:484 Expansion of small hyperplastic lesions to become macroscopically nodules, compressing adjacent cells. Pathbase: Pathology Committee hyperplastic nodules Pathbase: Curation May be used in some systems in preference to its synonyms to indicate lesion specific aprearances. A lesion characterised by changes of the type associated with invasive carcinoma, but physically bounded by the lining epithelium and without local invasion. mouse_pathology.ontology severe epithelial dysplasia severe intraepithelial neoplasia MPATH:485 Subsumed into MPATH: 132 carcinoma in situ true MPATH:485 May be used in some systems in preference to its synonyms to indicate lesion specific aprearances. A lesion characterised by changes of the type associated with invasive carcinoma, but physically bounded by the lining epithelium and without local invasion. Pathbase: Pathology Committee severe epithelial dysplasia Pathbase: Curation severe intraepithelial neoplasia Pathbase: Curation Pre-malignant hyperplastic and/or dysplastic change in the mammary gland epithelium with the potential to give rise to malignant tumors. mouse_pathology.ontology DIN Ductal carcinoma in situ MIN intraductal adenocarcinoma, non-infiltrating mammary intra-epithelial neoplasia MPATH:486 This term covers the range of DIN (MIN) including severe intra-epithelial neoplasia (IENIII), alternatively termed in situ carcinoma of the mammary ductal epithelium. (M- 8500/2). See Tavassoli FA. (1998) Mod Pathol. 11:140-54. Ductal carcinoma in situ: introduction of the concept of ductal intraepithelial neoplasia for further definition. ductal intra-epithelial neoplasia MPATH:486 Pre-malignant hyperplastic and/or dysplastic change in the mammary gland epithelium with the potential to give rise to malignant tumors. PMID:10713680 DIN Pathbase: Curation Ductal carcinoma in situ Pathbase: Curation MIN Pathbase: Curation intraductal adenocarcinoma, non-infiltrating Pathbase: Curation mammary intra-epithelial neoplasia Pathbase: Curation Histologically apparent areas of dysplasia that are not grossly visible (smaller than 0.5-1 mm). Lesions may involve single or multiple glands. mouse_pathology.ontology GIN IIN microadenoma MPATH:487 intestinal intra-epithelial neoplasia MPATH:487 Histologically apparent areas of dysplasia that are not grossly visible (smaller than 0.5-1 mm). Lesions may involve single or multiple glands. PMID:12612914 GIN Pathbase: Curation IIN Pathbase: Curation microadenoma Pathbase: Curation See reference for definition. URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/prostate_models/path_class_mouse mouse_pathology.ontology PIN MPATH:488 prostate intra-epithelial neoplasia MPATH:488 See reference for definition. ISBN:0-19-512338-7 PIN Pathbase: Curation stomach, oesophagus and pancreatic intra-epithelial neoplasia mouse_pathology.ontology PANIN MPATH:489 stomach, oesophagus and pancreatic intra-epithelial neoplasia MPATH:489 stomach, oesophagus and pancreatic intra-epithelial neoplasia ISBN:0-19-512338-7 PANIN Pathbase: Curation Reduction of myelin content in neuronal sheath. mouse_pathology.ontology MPATH:49 demyelination MPATH:49 Reduction of myelin content in neuronal sheath. Pathbase: Curation Benign neoplastic growth containing areas of adenomatous structure (progression). mouse_pathology.ontology polypoid adenoma, cellular polyp. MPATH:490 adenomatous polyp MPATH:490 Benign neoplastic growth containing areas of adenomatous structure (progression). Pathbase: Curation polypoid adenoma, cellular polyp. Pathbase: Curation A mass of tissue which projects outward or upward from the normal surface level being macroscopically visible as a hemispheroidal, spheroidal, or irregular moundlike structure growing from a relatively broad base or a slender stalk. mouse_pathology.ontology MPATH:491 polyp MPATH:491 A mass of tissue which projects outward or upward from the normal surface level being macroscopically visible as a hemispheroidal, spheroidal, or irregular moundlike structure growing from a relatively broad base or a slender stalk. ISBN:0781727286 Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material,. mouse_pathology.ontology MPATH:492 membraneous glomerulonephritis MPATH:492 Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material,. ISBN:0781727286 A chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix,. mouse_pathology.ontology MPATH:493 membraneoproliferative glomerulonephritis MPATH:493 A chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix,. ISBN:0781727286 Glomerulonephritis caused by autoimmune attack on the glomerulus. mouse_pathology.ontology MPATH:494 Needs multiple parentage with autoimmune mediated disease autoimmune glomerulonephritis MPATH:494 Glomerulonephritis caused by autoimmune attack on the glomerulus. ISBN:0781727286 Tumor derived from the capillary glomus with arteriovenous capillary anastomoses. Often characterized by multiple tumors resembling cavernous hemangioma (M-8712/0). mouse_pathology.ontology MPATH:495 glomangioma MPATH:495 Tumor derived from the capillary glomus with arteriovenous capillary anastomoses. Often characterized by multiple tumors resembling cavernous hemangioma (M-8712/0). Pathbase: Curation Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:496 Non-Lymphoid leukaemias MPATH:496 Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition. PMID:12070033 Leukaemia in which neoplastic cells are poorly differentiated and not monocytic. At least 90% of the cells have to be blasts. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology myeloblastic leukaemia without maturation myeloid leukaemia (myeloblastic type) poorly differentiated myeloid leukaemia MPATH:497 myeloid leukaemia without maturation MPATH:497 Leukaemia in which neoplastic cells are poorly differentiated and not monocytic. At least 90% of the cells have to be blasts. PMID:12070033 myeloblastic leukaemia without maturation Pathbase: Curation myeloid leukaemia (myeloblastic type) Pathbase: Curation poorly differentiated myeloid leukaemia Pathbase: Curation Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic but not monocytic component. At least 20% of the cells have to be blasts. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology myeloblastic laeukaemia with maturation poorly differentiated myeloid leukaemia MPATH:498 myeloid leukaemia with maturation MPATH:498 Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic but not monocytic component. At least 20% of the cells have to be blasts. PMID:12070033 myeloblastic laeukaemia with maturation Pathbase: Curation poorly differentiated myeloid leukaemia Pathbase: Curation Abnormal proliferation of beta cells of developing islets often leading to marked diffuse or focal beta-cell hyperplasia. Considered to generate a potentially cancerous lesion. mouse_pathology.ontology Beta-cell nesidioblastosis congenital insulinomas diffused or generalised islet cell hyperplasia endocrine dysplasia focal adenomatosis microadenomatosis multifocal and focal ductulo-insular proliferation (nesidioblastosis) nesidioblastoma nesidiodysplasia MPATH:499 nesidioblastosis MPATH:499 Abnormal proliferation of beta cells of developing islets often leading to marked diffuse or focal beta-cell hyperplasia. Considered to generate a potentially cancerous lesion. PMC:PMC1964945 Beta-cell nesidioblastosis Pathbase: Curation congenital insulinomas Pathbase: Curation diffused or generalised islet cell hyperplasia Pathbase: Curation endocrine dysplasia Pathbase: Curation focal adenomatosis Pathbase: Curation microadenomatosis Pathbase: Curation multifocal and focal ductulo-insular proliferation (nesidioblastosis) Pathbase: Curation nesidioblastoma Pathbase: Curation nesidiodysplasia Pathbase: Curation Area of liver necrosis that bridges adjacent portal areas and central veins. mouse_pathology.ontology MPATH:5 bridging necrosis MPATH:5 Area of liver necrosis that bridges adjacent portal areas and central veins. ISBN:0781727286 Reduction in intracellular glycogen content. mouse_pathology.ontology MPATH:50 glycogen depletion MPATH:50 Reduction in intracellular glycogen content. Pathbase: Curation Leukaemia in which neoplastic cells are well differentiated and in which there are fewer than 20% blasts. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology myeloid leukaemia, chonic type well differentiated myeloid leukaemia MPATH:500 myeloproliferative disease-like myeloid leukaemia MPATH:500 Leukaemia in which neoplastic cells are well differentiated and in which there are fewer than 20% blasts. PMID:12070033 myeloid leukaemia, chonic type Pathbase: Curation well differentiated myeloid leukaemia Pathbase: Curation Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic and a monocytic component. At least 20% of the cells have to be blasts. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology myeloid leukaemia, myelomonocytic type MPATH:501 myelomonocytic leukaemia MPATH:501 Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic and a monocytic component. At least 20% of the cells have to be blasts. PMID:12070033 myeloid leukaemia, myelomonocytic type Pathbase: Curation Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:502 monocytic leukaemia MPATH:502 Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts. PMID:12070033 A leukaemia with at least 90% blasts and differentiation markers of the myeloid and lymphoid lineage. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:503 biphenotypic leukaemia MPATH:503 A leukaemia with at least 90% blasts and differentiation markers of the myeloid and lymphoid lineage. PMID:12070033 Solid tumor mass composed of non-lymphoid haematopoietic cells. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:504 non-lymphoid hematopoietic sarcomas MPATH:504 Solid tumor mass composed of non-lymphoid haematopoietic cells. PMID:12070033 Solid tumor mass composed predominantly of granulocytic or relatively undifferentiated non-lymphoid haematopoietic cells. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:505 granulocytic sarcoma MPATH:505 Solid tumor mass composed predominantly of granulocytic or relatively undifferentiated non-lymphoid haematopoietic cells. PMID:12070033 Solid tumor mass composed predominantly of histiocytic cells (M-9775/3). URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology Kupffer cell sarcoma (sensu liver) histiocytic lymphoma malignant lymphoma, histiocytic type reticulum cell sarcoma, type A reticulum cell sarcoma, type A, reticulosarcoma MPATH:506 histiocytic sarcoma MPATH:506 Solid tumor mass composed predominantly of histiocytic cells (M-9775/3). PMID:12070033 Kupffer cell sarcoma (sensu liver) Pathbase: Curation histiocytic lymphoma Pathbase: Curation malignant lymphoma, histiocytic type Pathbase: Curation reticulum cell sarcoma, type A Pathbase: Curation reticulum cell sarcoma, type A, reticulosarcoma Pathbase: Curation Solid tumor mass composed of mast cells. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology malignant mastocytoma mast cell tumor mastocytosis MPATH:507 mast cell sarcoma MPATH:507 Solid tumor mass composed of mast cells. PMID:12070033 malignant mastocytoma Pathbase: Curation mast cell tumor Pathbase: Curation mastocytosis Pathbase: Curation Haematopoietic proliferation with evidence of trilineage dysplasia. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:508 myeloid dysplasias MPATH:508 Haematopoietic proliferation with evidence of trilineage dysplasia. PMID:12070033 Haematopoietic proliferation with evidence of trilineage dysplasia. More than 20% should be blasts. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:509 cytopenia with increased blasts MPATH:509 Haematopoietic proliferation with evidence of trilineage dysplasia. More than 20% should be blasts. PMID:12070033 Intrinsic abnormally low level of calcification in a tissue cf. MPATH: 48. mouse_pathology.ontology MPATH:51 hypocalcification MPATH:51 Intrinsic abnormally low level of calcification in a tissue cf. MPATH: 48. Pathbase: Curation Non-reactive persistent accumulation of non-lymphoid haematopoietic cells. Genetically determined. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:510 myeloid proliferations (non-reactive) MPATH:510 Non-reactive persistent accumulation of non-lymphoid haematopoietic cells. Genetically determined. PMID:12070033 Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which do not infiltrate the spleen and the bone marrow. Genetically determined. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:511 myeloproliferation (genetic) MPATH:511 Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which do not infiltrate the spleen and the bone marrow. Genetically determined. PMID:12070033 Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which infiltrate the spleen and the bone marrow. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:512 myeloproliferative disease MPATH:512 Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which infiltrate the spleen and the bone marrow. PMID:12070033 Neoplasms of the B or T cell lineage. mouse_pathology.ontology MPATH:513 lymphoid neoplasms MPATH:513 Neoplasms of the B or T cell lineage. PMID:12070034 B cell neoplasms mouse_pathology.ontology MPATH:514 B cell neoplasms true MPATH:514 B cell neoplasms Pathbase: Pathology Committee Hematological neoplasias of non-lymphoid origin. URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2 mouse_pathology.ontology MPATH:515 non-Lymphoid neoplasias MPATH:515 Hematological neoplasias of non-lymphoid origin. PMID:12070033 Neoplasm of the B cell lymphoid lineage. mouse_pathology.ontology MPATH:516 B-cell neoplasms MPATH:516 Neoplasm of the B cell lymphoid lineage. Pathbase: Curation Lymphoma originating from precursor B-cells. mouse_pathology.ontology MPATH:517 precursor B cell neoplasms MPATH:517 Lymphoma originating from precursor B-cells. PMID:12070034 Lymphoma originating in a precursor B-cell. mouse_pathology.ontology lymphoblastic leukaemia lymphoblastic lymphoma MPATH:518 precursor B -cell lymphoblastic lymphoma/leukaemia MPATH:518 Lymphoma originating in a precursor B-cell. PMID:12070034 lymphoblastic leukaemia Pathbase: Curation lymphoblastic lymphoma Pathbase: Curation Lymphomas originating in peripheral B cells. mouse_pathology.ontology MPATH:519 mature B-cell neoplasms MPATH:519 Lymphomas originating in peripheral B cells. PMID:12070034 Reduction in cellular or plasma lipid content. mouse_pathology.ontology MPATH:52 lipid depletion MPATH:52 Reduction in cellular or plasma lipid content. Pathbase: Curation Diffuse accumulation of small mature B-cells. mouse_pathology.ontology small lymphocytic lymphoma well differentiated lymphocytic lymphoma MPATH:520 small B-cell lymphoma MPATH:520 Diffuse accumulation of small mature B-cells. Book: Morse; et al. (2002) Blood 100; 246-258 small lymphocytic lymphoma Pathbase: Curation well differentiated lymphocytic lymphoma Pathbase: Curation A lymphoid proliferation of cells of the marginal zone of the white pulp of the spleen. mouse_pathology.ontology SMZL MPATH:521 splenic marginal zone lymphoma MPATH:521 A lymphoid proliferation of cells of the marginal zone of the white pulp of the spleen. PMID:12070034 SMZL Pathbase: Curation A lymphoid proliferation composed of a mixture of centroblasts and centrocytes that may or may not have a nodular(follicular)pattern. The follicular dendritic cell network is not present, unlike in the human. The equivalent typical translocation (Chr. 14:18 )seen in humans has not been reported in the mouse. mouse_pathology.ontology centroblastic/centrocytic lymphoma follicular center cell lymphoma, small cell or mixed follicular lymphoma MPATH:522 follicular B cell lymphoma MPATH:522 A lymphoid proliferation composed of a mixture of centroblasts and centrocytes that may or may not have a nodular(follicular)pattern. The follicular dendritic cell network is not present, unlike in the human. The equivalent typical translocation (Chr. 14:18 )seen in humans has not been reported in the mouse. PMID:12070034 centroblastic/centrocytic lymphoma Pathbase: Curation follicular center cell lymphoma, small cell or mixed Pathbase: Curation follicular lymphoma Pathbase: Curation Diffuse proliferation of large B lymphoid cells. mouse_pathology.ontology DLBCL MPATH:523 diffuse large B-cell lymphoma MPATH:523 Diffuse proliferation of large B lymphoid cells. PMID:12070034 DLBCL Pathbase: Curation Diffuse follicular centre cell lymphoma mainly composed of centroblasts. mouse_pathology.ontology centroblastic lymphoma MPATH:524 diffuse large B-cell lymphoma, centroblastic type MPATH:524 Diffuse follicular centre cell lymphoma mainly composed of centroblasts. PMID:12070034 centroblastic lymphoma Pathbase: Curation Diffuse large B cell lymphoma with increased number of immunoblasts. mouse_pathology.ontology Immunoblastic lymphoma MPATH:525 diffuse large B-cell lymphoma, immunoblastic type MPATH:525 Diffuse large B cell lymphoma with increased number of immunoblasts. PMID:12070034 Immunoblastic lymphoma Pathbase: Curation Diffuse large B-cell lymphoma with more than 50% histiocytes. mouse_pathology.ontology DLCL (HS) MPATH:526 diffuse large B-cell lymphoma, histiocyte associated MPATH:526 Diffuse large B-cell lymphoma with more than 50% histiocytes. PMID:12070034 DLCL (HS) Pathbase: Curation Primary B-cell lymphoma of the thymus. Reported in C57BL/6 mice infected with replication defective MuLV. Not clear that this is the equivalent of the human disease. mouse_pathology.ontology MPATH:527 primary mediastinal (thymic) diffuse large B cell lymphoma MPATH:527 Primary B-cell lymphoma of the thymus. Reported in C57BL/6 mice infected with replication defective MuLV. Not clear that this is the equivalent of the human disease. PMID:12070034 Highly proliferative B-cell lymphoma characteristically seen in c-Myc transgenic mice, derived from mature B cells. mouse_pathology.ontology MPATH:528 classic Burkitt lymphoma MPATH:528 Highly proliferative B-cell lymphoma characteristically seen in c-Myc transgenic mice, derived from mature B cells. PMID:12070034 Highly proliferative mature B-cell lymphoma, poorly defined. mouse_pathology.ontology MPATH:529 Burkitt-like lymphoma MPATH:529 Highly proliferative mature B-cell lymphoma, poorly defined. PMID:12070034 Reduced bone mass due to inadequate synthesis of osteoid, resulting in decreased calcification. mouse_pathology.ontology MPATH:53 osteopenia MPATH:53 Reduced bone mass due to inadequate synthesis of osteoid, resulting in decreased calcification. ISBN:0781727286 Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3). URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class mouse_pathology.ontology Myeloma ( human ) MPATH:530 plasma cell neoplasms MPATH:530 Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3). PMID:12070034 Myeloma ( human ) Pathbase: Curation Unusual lymphoma type described in thymectomised (SL/Kh x AKR/Ms) F1 mice. No equivalent found in human to date. See reference for detailed phenotype. mouse_pathology.ontology MPATH:531 B-natural killer cell lymphoma MPATH:531 Unusual lymphoma type described in thymectomised (SL/Kh x AKR/Ms) F1 mice. No equivalent found in human to date. See reference for detailed phenotype. Lu; L-M.; et al (1999) Jpn J. Cancer Res. 90: 1218-1223 Diffuse proliferation of mature plasma cells. Clonal by definition. URL: http://emice.nci.nih.gov/emice/mouse_models/organ_models/hema_models/hema_mouse_class mouse_pathology.ontology MPATH:532 Tissue, usually lymph nodes, that contain unusually large numbers of normal appearing plasma cells. While these may be plasmacytomas, additional work is needed to confirm this latter diagnosis. plasmacytoma MPATH:532 Diffuse proliferation of mature plasma cells. Clonal by definition. PMID:12070034 Diffuse proliferation of mature plasma cells. Clonal by definition. Frequently found in IL6 transgenic mice. Characteristically involves spleen and nodes rather than peritoneum. mouse_pathology.ontology MPATH:533 extraosseous plasmacytoma MPATH:533 Diffuse proliferation of mature plasma cells. Clonal by definition. Frequently found in IL6 transgenic mice. Characteristically involves spleen and nodes rather than peritoneum. PMID:12070034 Diffuse proliferation of immature plasma cells or plasma blasts. mouse_pathology.ontology MPATH:534 anaplastic plasmacytoma MPATH:534 Diffuse proliferation of immature plasma cells or plasma blasts. PMID:12070034 Neoplasms derived from cells of the T lymphocyte lineage. mouse_pathology.ontology MPATH:535 T-cell neoplasms MPATH:535 Neoplasms derived from cells of the T lymphocyte lineage. PMID:12070034 Neoplasms of precursor T cells. mouse_pathology.ontology MPATH:536 precursor T-cell neoplasms MPATH:536 Neoplasms of precursor T cells. PMID:12070034 Precursor T cell derived neoplasia. Most commonly found in the thymus. mouse_pathology.ontology thymic lymphoma MPATH:537 precursor T-cell lymphoblastic lymphoma/leukaemia MPATH:537 Precursor T cell derived neoplasia. Most commonly found in the thymus. PMID:12070034 thymic lymphoma Pathbase: Curation Non-thymic neoplasms of mature T cell origin. mouse_pathology.ontology MPATH:538 mature T-cell neoplasms MPATH:538 Non-thymic neoplasms of mature T cell origin. PMID:12070034 Accumulation of small mature T cells. No human counterpart known to date. mouse_pathology.ontology MPATH:539 small T-cell lymphoma MPATH:539 Accumulation of small mature T cells. No human counterpart known to date. PMID:12070034 Reduction in the quantity of bone or atrophy of skeletal tissue. More severe than MPATH: 53 with gross changes to bone matrix. mouse_pathology.ontology MPATH:54 osteoporosis MPATH:54 Reduction in the quantity of bone or atrophy of skeletal tissue. More severe than MPATH: 53 with gross changes to bone matrix. ISBN:0781727286 T cell neoplasms which cannot currently be classified into known subtypes. mouse_pathology.ontology MPATH:540 T cell neoplasms character undetermined MPATH:540 T cell neoplasms which cannot currently be classified into known subtypes. PMID:12070034 Diffuse large pleiomorphic T cell lymphoma. This entity does not correspond to human anaplastic large cell lymphoma. mouse_pathology.ontology MPATH:541 T large cell anaplastic lymphoma MPATH:541 Diffuse large pleiomorphic T cell lymphoma. This entity does not correspond to human anaplastic large cell lymphoma. PMID:12070034 Neoplasm of large granular T cells of CD8 phenotype. mouse_pathology.ontology MPATH:542 T natural killer cell lymphoma MPATH:542 Neoplasm of large granular T cells of CD8 phenotype. PMID:12070034 Benign neoplasm of the biliary duct. Occurs in solid and cystic forms. (M-8160/0). mouse_pathology.ontology MPATH:543 cholangioma MPATH:543 Benign neoplasm of the biliary duct. Occurs in solid and cystic forms. (M-8160/0). Pathbase: Pathology Committee Benign tumor of unknown origin showing features of hepatocelluar adenoma and cholangioma. mouse_pathology.ontology MPATH:544 hepatocholangiocellular adenoma MPATH:544 Benign tumor of unknown origin showing features of hepatocelluar adenoma and cholangioma. Pathbase: Pathology Committee Malignant tumor of unknown origin showing features of hepatocelluar carcinoma and cholangiocarcinoma. (M-8180/3). mouse_pathology.ontology MPATH:545 hepatocholangiocellular carcinoma MPATH:545 Malignant tumor of unknown origin showing features of hepatocelluar carcinoma and cholangiocarcinoma. (M-8180/3). Pathbase: Pathology Committee George Gkoutos 2011-03-22T03:07:49Z mouse_pathology.ontology MPATH:546 blepharitis MPATH:546 Extracellular accumulation of mucous secretions. mouse_pathology.ontology MPATH:547 Mucus is the clear viscous secretion of the mucous membranes. Consisting of mucin, epithelial cells, leukocytes and various inorganic salts dissolved in water. mucous secretions MPATH:547 Extracellular accumulation of mucous secretions. Pathbase: Pathology Committee A generally malignant neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by atypical neoplastic epithelial or urothelial cells cells. mouse_pathology.ontology MPATH:548 papillary transitional cell carcinoma MPATH:548 A generally malignant neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by atypical neoplastic epithelial or urothelial cells cells. Book: Kunze; E. (1994) Preneoplastic and neoplastic lesions of the Rat urinary bladder. In; Pathology of Neoplasia and Preneoplasia in Rodents. Eds. Bannach; P.; and Goessner; W.; Vol 1 p 114. Schattauer; Stuttgart New York Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma). mouse_pathology.ontology MPATH:549 carcinoma MPATH:549 Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma). Pathbase: Curation Developmental and structural abnormalities occurring during embryonic development or during adult life. mouse_pathology.ontology MPATH:55 developmental and structural abnormality MPATH:55 Developmental and structural abnormalities occurring during embryonic development or during adult life. Pathbase: Pathology Committee A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells. mouse_pathology.ontology MPATH:550 sarcoma true MPATH:550 A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells. Pathbase: Pathology Committee A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells. mouse_pathology.ontology MPATH:551 sarcoma MPATH:551 A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells. Pathbase: Curation Benign tumor of the Clara cells of the bronchioalveolar epithelium. URL: http://emice.nci.nih.gov/mouse_models/organ_models/lung_models/murinecancer/tumorclass mouse_pathology.ontology MPATH:552 Merged with MPATH:272 following recommendations of MMHC 2003. Clara cell adenoma true MPATH:552 Benign tumor of the Clara cells of the bronchioalveolar epithelium. Book: Hahn; F.F. and Boorman; GA. neoplasia and pre-neoplasia in the lung. In Pathology of Neoplasia and Preneoplasia in Rodents. Vol.2. p 39. (1997) Schattauer ( Stuttgart and New York) Inflammation of a nerve. mouse_pathology.ontology MPATH:553 neuritis MPATH:553 Inflammation of a nerve. ISBN:0781727286 Regressive changes which may increase in severity, and which may result from defective nutrition or support of a tissue or organ. mouse_pathology.ontology MPATH:554 Most often used for diseases in which a structure does not develop properly (not necessarily in an embryonic context) and undergoes degradation. dystrophy MPATH:554 Regressive changes which may increase in severity, and which may result from defective nutrition or support of a tissue or organ. Pathbase: Pathology Committee Deposition of any homogeneous inorganic material. mouse_pathology.ontology MPATH:555 mineralisation MPATH:555 Deposition of any homogeneous inorganic material. ISBN:0781727286 Lesions which in some cases have the potential to become progressively growing malignant tumors. mouse_pathology.ontology MPATH:556 potentially cancerous lesions MPATH:556 Lesions which in some cases have the potential to become progressively growing malignant tumors. Pathbase: Pathology Committee Sensu gastrointsestinal tract. visible microscopically in whole mount colonic tissue. One or more crypts larger than most, have a thickened layer of epithelial cells that stain more intensely with methylene blue. Some have a slit shaped luminal opening, and increased pericryptal space and are elevated from the focal plane of the microscope. ACF is not a histologic diagnosis. mouse_pathology.ontology ACF MPATH:557 Use IEN1 MPATH:130 instead. Suppressed as not strictly a histological diagnosis. aberrant crypt foci true MPATH:557 Sensu gastrointsestinal tract. visible microscopically in whole mount colonic tissue. One or more crypts larger than most, have a thickened layer of epithelial cells that stain more intensely with methylene blue. Some have a slit shaped luminal opening, and increased pericryptal space and are elevated from the focal plane of the microscope. ACF is not a histologic diagnosis. PMID:12612914 ACF Pathbase: Curation Adenocarcinoma type tumor with both glandular and squamous differentiation. (M-8983/0). mouse_pathology.ontology MPATH:558 adenomyoepithelioma MPATH:558 Adenocarcinoma type tumor with both glandular and squamous differentiation. (M-8983/0). PMID:10713680 Tumor composed of small glandular clusters with small lumens. mouse_pathology.ontology MPATH:559 acinar adenocarcinoma MPATH:559 Tumor composed of small glandular clusters with small lumens. PMID:10713680 Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult. mouse_pathology.ontology MPATH:56 developmental or adult structural defect MPATH:56 Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult. Pathbase: Pathology Committee Tumor composed of sheets or nests of cells forming lumens with round, punched out spaces. mouse_pathology.ontology MPATH:560 cribriform adenocarcinoma MPATH:560 Tumor composed of sheets or nests of cells forming lumens with round, punched out spaces. PMID:10713680 Mixed adeno- and squamous cell carcinoma. Not yet reported in mice. M-8560/3. mouse_pathology.ontology MPATH:561 adenosquamous carcinoma MPATH:561 Mixed adeno- and squamous cell carcinoma. Not yet reported in mice. M-8560/3. PMID:12612914 The twisting of a bodily organ or part on its own axis. mouse_pathology.ontology MPATH:562 torsion MPATH:562 The twisting of a bodily organ or part on its own axis. Pathbase: Pathology Committee carcinoma derived from gastrointestinal epithelium with a high mucinous content. (M-8480/3). mouse_pathology.ontology mucinous adenocarcinoma MPATH:563 mucinous carcinoma MPATH:563 carcinoma derived from gastrointestinal epithelium with a high mucinous content. (M-8480/3). PMID:12612914 mucinous adenocarcinoma Pathbase: Curation Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3). mouse_pathology.ontology glioblastoma multiforme monstrocytoma MPATH:564 Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. glioblastoma MPATH:564 Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3). ISBN-13:9783794515530 glioblastoma multiforme Pathbase: Curation monstrocytoma Pathbase: Curation Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium. mouse_pathology.ontology MPATH:565 tumors of neurepithelial tissue MPATH:565 Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium. Pathbase: Pathology Committee tumors of the meninges mouse_pathology.ontology MPATH:566 tumors of the meninges MPATH:566 tumors of the meninges Pathbase: Curation Glial cell derived tumor composed of bipolar cells with long `hairlike` GFAP-positive processes. (M9421/1). mouse_pathology.ontology cystic cerebellar astrocytoma MPATH:567 Often cystic in children and generally considered benign. pilocytic astrocytoma MPATH:567 Glial cell derived tumor composed of bipolar cells with long `hairlike` GFAP-positive processes. (M9421/1). Nervous System. Radovsky A and Mahler; J.S. In: Maronpot; R. Pathology of the Mouse. (1999) Cache River Press. Vienna IL cystic cerebellar astrocytoma Pathbase: Curation Mixed tumor containing astrocytes within an oligodendroglioma or vice versa. In some cases both components may be neoplastic. (M-9382/3). mouse_pathology.ontology MPATH:568 Also see Weiss, W.W, Israel, M. Cobbs, C., et al. (2002) Oncogene 21, 7453-7463. mixed glioma MPATH:568 Mixed tumor containing astrocytes within an oligodendroglioma or vice versa. In some cases both components may be neoplastic. (M-9382/3). ISBN-13:9783794515530 granular cell tumor mouse_pathology.ontology MPATH:569 Subsumed into MP:413 as incidence in meninges, whilst a characteristic lesion, is the same type of tumor as that originally classified under myomatous tumors. Describe meningeal granular cell tumor using MP:413 and the anatomical descriptor. granular cell tumor true MPATH:569 granular cell tumor ISBN-13:9783794515530 Failure of a tissue or organ to develop. mouse_pathology.ontology Agenesia MPATH:57 agenesis MPATH:57 Failure of a tissue or organ to develop. Pathbase: Pathology Committee Agenesia Pathbase: Curation Tumors of the peripheral nervous system. mouse_pathology.ontology MPATH:570 peripheral nervous system tumors MPATH:570 Tumors of the peripheral nervous system. Pathbase: Pathology Committee Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common. mouse_pathology.ontology MPATH:571 pilomatricoma MPATH:571 Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common. See: Gat; U.; DasGupta; R.; Degenstein; L. and Fuchs; E. (1998) De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin Cell; 95; 605-614. Ossifying fibromas are benign tumors derived from pluripotential mesenchymal stem cells or osteoblasts. Occur spontaneously or in response to radiation. Preferentially located in mandible, maxilla and caudal spine. Composed of a characteristically regular trabecular bone pattern embedded in a fibrous stroma. Proliferating component consists of spindle cells which give rise to cuboidal osteoblasts to form rounded bodies or trabeculae. Bone trabeculae resemble the alphabet soup shapes characteristic of fibrous dysplasia in humans. In contrast to fibrous dysplasia the bone trabeculae of ossifying fibroma are mostly lamellar and ringed by active osteoblasts. mouse_pathology.ontology MPATH:572 ossifying fibroma MPATH:572 Ossifying fibromas are benign tumors derived from pluripotential mesenchymal stem cells or osteoblasts. Occur spontaneously or in response to radiation. Preferentially located in mandible, maxilla and caudal spine. Composed of a characteristically regular trabecular bone pattern embedded in a fibrous stroma. Proliferating component consists of spindle cells which give rise to cuboidal osteoblasts to form rounded bodies or trabeculae. Bone trabeculae resemble the alphabet soup shapes characteristic of fibrous dysplasia in humans. In contrast to fibrous dysplasia the bone trabeculae of ossifying fibroma are mostly lamellar and ringed by active osteoblasts. Book: Luz A; Goessner; W.;and Murray AB.(1991) Ossifying fibroma; mouse. In; Jones TC; Mohr U; Hunt RD (eds) Monographs on pathology of laboratory animals. Cardiovascular and musculoskeletal systems. Springer; Berlin Heidelberg New York Tokyo; pp 228-232 Pre-malignant lesion of transitional cells, papillomatous form, in which proliferating epithelium is invaginated beneath the surface. mouse_pathology.ontology MPATH:573 inverted transitional cell papilloma MPATH:573 Pre-malignant lesion of transitional cells, papillomatous form, in which proliferating epithelium is invaginated beneath the surface. Pathbase: Curation Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests. mouse_pathology.ontology MPATH:574 nephroblastomatosis MPATH:574 Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests. PMID:8383276 This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation. mouse_pathology.ontology MPATH:575 basaloid follicular neoplasms MPATH:575 This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation. URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models Basaloid neoplasm with numerous mature hair follicles and hair formation. mouse_pathology.ontology MPATH:576 trichofolliculoma MPATH:576 Basaloid neoplasm with numerous mature hair follicles and hair formation. URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models Cellular neoplasm with well formed palisades of basaloid cells adjacent to less basophilic smaller cells with occasional central deposition of amorphous eosinophilic material. These tumors share some features with cylindroma type tumors but have a less well developed jigsaw puzzle-like architecture and tend to be more cellular. mouse_pathology.ontology MPATH:577 spiradenoma MPATH:577 Cellular neoplasm with well formed palisades of basaloid cells adjacent to less basophilic smaller cells with occasional central deposition of amorphous eosinophilic material. These tumors share some features with cylindroma type tumors but have a less well developed jigsaw puzzle-like architecture and tend to be more cellular. URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification Basaloid neoplasm with frequent primitive hair follicles. mouse_pathology.ontology MPATH:578 trichoblastoma MPATH:578 Basaloid neoplasm with frequent primitive hair follicles. URL:http://emice.nci.nih.gov/emice/mouse_models/organ_models/skin_models/hierarchical_classification Loss of epithelium and the basement membrane (full thickness). Cf Erosion. mouse_pathology.ontology MPATH:579 ulcer MPATH:579 Loss of epithelium and the basement membrane (full thickness). Cf Erosion. Pathbase: Pathology Committee Absence of an organ or tissue coupled with persistence of the organ/tissue primordium, which fails to develop completely. mouse_pathology.ontology MPATH:58 aplasia MPATH:58 Absence of an organ or tissue coupled with persistence of the organ/tissue primordium, which fails to develop completely. ISBN:0781727286 Partial epithelial denudation not penetrating to the basement membrane. mouse_pathology.ontology MPATH:580 erosion MPATH:580 Partial epithelial denudation not penetrating to the basement membrane. Pathbase: Pathology Committee Connective tissue proliferative reaction induced by a neoplastic process. mouse_pathology.ontology scirrhous sclerosis MPATH:581 desmoplasia MPATH:581 Connective tissue proliferative reaction induced by a neoplastic process. Pathbase: Pathology Committee scirrhous Pathbase: Curation sclerosis Pathbase: Curation Scarring of the hair follicle without affecting the adjacent dermis. Pigment may be associated with fibrous tract in pigmented individuals. mouse_pathology.ontology MPATH:582 cicatricial alopecia MPATH:582 Scarring of the hair follicle without affecting the adjacent dermis. Pigment may be associated with fibrous tract in pigmented individuals. Pathbase: Curation Loss of hair follicles in a diffuse dermal scar. mouse_pathology.ontology MPATH:583 scarring alopecia MPATH:583 Loss of hair follicles in a diffuse dermal scar. Pathbase: Pathology Committee In mice the term refers to accumulation of fibrous connective tissue in the medullary cavity of bones; usually in old mice. In humans the term is synonymous with myeloid metaplasia. mouse_pathology.ontology MPATH:584 myelofibrosis MPATH:584 In mice the term refers to accumulation of fibrous connective tissue in the medullary cavity of bones; usually in old mice. In humans the term is synonymous with myeloid metaplasia. Pathbase: Pathology Committee A mixed inflammatory infiltrate in the pulmonary airways with predominant intra-alveolar macrophage component with intra- and extracellular, elongated, bright eosinophilic/acidophilic crystals. mouse_pathology.ontology MPATH:585 Crystals and acidophilic material have been reported as various materials including Ym1 and Ym2 proteins and blood pigment derivatives and Eotaxin. acidophilic macrophage pneumonia MPATH:585 A mixed inflammatory infiltrate in the pulmonary airways with predominant intra-alveolar macrophage component with intra- and extracellular, elongated, bright eosinophilic/acidophilic crystals. :Murray AB; Luz A ( 1990 ) Acidophilic macrophage pneumonia in laboratory mice. Vet Pathol. 27; 274-81 A group of degenerative disorders resulting in multiple cysts in tissues. mouse_pathology.ontology polycystic kidney disease polycystic liver disease polycystic ovary MPATH:586 polycystic disease MPATH:586 A group of degenerative disorders resulting in multiple cysts in tissues. Pathbase: Pathology Committee polycystic kidney disease Pathbase: Curation polycystic liver disease Pathbase: Curation polycystic ovary Pathbase: Curation The lesion is characterized microscopically by epithelial cells with atypical hyperchromatic nuclei, vacuolization, intratubular lumina formation, infrequent apoptosis, and rare mitotic figures. In contrast to germ cells, the cells of CEH do not express alpha-fetoprotein, carcinoembryonic antigen, or S-100. Ultrastructurally, the cells are pleomorphic with stereocilia at their apical borders and within intratubular lumina, and are supported by a basement membrane. CEH does not appear to be a preneoplastic change. mouse_pathology.ontology MPATH:587 Cribriform epididymal hyperplasia was initially described as an incidental finding in human orchidectomy specimens. Recently, this condition was also described in mice, homozygous for a targeted mutation in p53. Cribriform epididymal hyperplasia MPATH:587 The lesion is characterized microscopically by epithelial cells with atypical hyperchromatic nuclei, vacuolization, intratubular lumina formation, infrequent apoptosis, and rare mitotic figures. In contrast to germ cells, the cells of CEH do not express alpha-fetoprotein, carcinoembryonic antigen, or S-100. Ultrastructurally, the cells are pleomorphic with stereocilia at their apical borders and within intratubular lumina, and are supported by a basement membrane. CEH does not appear to be a preneoplastic change. Journal: La Perle KM; Blomme EA; Sagartz JE; Capen CC (2002) Epididymal cribriform hyperplasia with nuclear atypia in p53 homozygous knockout. Comp Med. 2002 52:568-71. Dysplasia mouse_pathology.ontology MPATH:588 dysplasia true MPATH:588 Dysplasia Pathbase: Pathology Committee Distortion or deficiency of the tissue or cellular architecture. mouse_pathology.ontology MPATH:589 Note that with respect to developmental processes the term dysplasia is often used with greater specificity to describe aberrant developmental processes of proliferation and differentation, in which case MPATH: 64 Developmental dysplasia should be used. dysplasia MPATH:589 Distortion or deficiency of the tissue or cellular architecture. Pathbase: Pathology Committee Defect in the process determining number, angle, pattern or rate of branching of tubular branched structures eg. Glandular ducts. mouse_pathology.ontology MPATH:59 defective branching morphogenesis MPATH:59 Defect in the process determining number, angle, pattern or rate of branching of tubular branched structures eg. Glandular ducts. Pathbase: Pathology Committee Lesion of bone showing accelerated osteoclastic bone resorption coupled with fibroplasia. Later stages show proliferation of osteoblasts. mouse_pathology.ontology fibrous dysplasia fibrous osteodystrophy osteodysplasia osteodystrophy osteofibrosis MPATH:590 The benign fibro-osseous lesions (BFOL) represent a clinically diverse group of disorders of bone that share similar histopathologic features. As a group, they are relatively common in the craniofacial complex, especially the jaws. Common in some inbred strains notably B6C3F1 females. Note that many of the synonyms have been used historically and may not be accurate. See: Albassam MA, Courtney CL (1996) Nonneoplastic and neoplastic lesions of the bone. In: Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM (eds) Pathobiology of the aging mouse. Vol 2. Musculoskeletal system. ILSI Press, Washington D.C., pp 425-437. AND Albassam MA, Wojcinski ZW, Barsoum NJ, Smith, GS (1991) Spontaneous fibro-osseous proliferative lesions in the sternums and femurs of B6C3F1 mice. Vet Path 28: 381-388. fibro-osseous lesion MPATH:590 Lesion of bone showing accelerated osteoclastic bone resorption coupled with fibroplasia. Later stages show proliferation of osteoblasts. Book: Albassam MA; Courtney CL (1996) Nonneoplastic and neoplastic lesions of the bone. In; Mohr U; Dungworth DL; Capen CC; Carlton WW; Sundberg JP; Ward JM (eds) Pathobiology of the aging mouse. Vol 2. Musculoskeletal system. ILSI Press; Washington D.C.; pp 425-437 fibrous dysplasia Pathbase: Curation fibrous osteodystrophy Pathbase: Curation osteodysplasia Pathbase: Curation osteodystrophy Pathbase: Curation osteofibrosis Pathbase: Curation Accumulation of mature adipose tissue in a healing wound site or otherwise in response to tissue damage. mouse_pathology.ontology MPATH:591 fatty infiltration MPATH:591 Accumulation of mature adipose tissue in a healing wound site or otherwise in response to tissue damage. Pathbase: Pathology Committee Excessive formation of dense trabecular bone and mineralized cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness. mouse_pathology.ontology Albers-Schoenberg disease marble bone disease marble bones MPATH:592 osteopetrosis MPATH:592 Excessive formation of dense trabecular bone and mineralized cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness. PMID:15625335 Albers-Schoenberg disease Pathbase: Curation marble bone disease Pathbase: Curation marble bones Pathbase: Curation Plasma cell myeloma - (ICD-O 9732/3). mouse_pathology.ontology MPATH:593 myeloma true MPATH:593 Plasma cell myeloma - (ICD-O 9732/3). Pathbase: Pathology Committee Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium. mouse_pathology.ontology MPATH:594 cystic hyperplasia MPATH:594 Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium. Pathbase: Pathology Committee The formation of and development of blood cells outside the red pulp of the spleen. Composed of varying numbers of megakaryocytes as well as myeloid and erythroid precursors. mouse_pathology.ontology MPATH:595 Production of blood cells in tissues other than the bone marrow. In the mouse, this is usually the liver. extramedullary hemopoiesis MPATH:595 The formation of and development of blood cells outside the red pulp of the spleen. Composed of varying numbers of megakaryocytes as well as myeloid and erythroid precursors. :Ward; J.M.; Mann; P.C.; Mrishima; H.; and Frith; C.H. Thymus; Spleen and Lymph nodes. Ch 13. p342. In Maronpot; R. Pathology of the Mouse. (1999) Cache River Press. Vienna IL The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion. mouse_pathology.ontology MPATH:596 pathological process MPATH:596 The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion. Pathbase: Pathology Committee Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology. mouse_pathology.ontology MPATH:597 cell and tissue damage process MPATH:597 Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology. Pathbase: Pathology Committee degenerative entity mouse_pathology.ontology MPATH:598 degenerative entity true MPATH:598 degenerative entity Pathbase: Pathology Committee developmental process abnormalities mouse_pathology.ontology MPATH:599 developmental process abnormalities MPATH:599 developmental process abnormalities Pathbase: Pathology Committee Necrosis characteristic of some inflammatory conditions which represents necrosis with loss of structure of the various cellular and tissue elements; affected tissue manifests a friable, crumbly consistency. mouse_pathology.ontology MPATH:6 caseous necrosis MPATH:6 Necrosis characteristic of some inflammatory conditions which represents necrosis with loss of structure of the various cellular and tissue elements; affected tissue manifests a friable, crumbly consistency. ISBN:0781727286 Failure of two cavities, voids or lumens to connect. mouse_pathology.ontology MPATH:60 communication defect MPATH:60 Failure of two cavities, voids or lumens to connect. Pathbase: Curation Aberrant branch or branching pattern of a branched structure such as the bronchus. mouse_pathology.ontology MPATH:600 branching defect MPATH:600 Aberrant branch or branching pattern of a branched structure such as the bronchus. Pathbase: Curation Increase of the size or cellularity of an organ or tissue as a consequence of loss of normal regulation of cell proliferation. mouse_pathology.ontology MPATH:601 developmental hypertrophy MPATH:601 Increase of the size or cellularity of an organ or tissue as a consequence of loss of normal regulation of cell proliferation. Pathbase: Pathology Committee An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation. mouse_pathology.ontology MPATH:602 hyperplastic tissue MPATH:602 An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation. Pathbase: Pathology Committee Anatomically located instance of pathological response or entity. mouse_pathology.ontology MPATH:603 pathological anatomical entity MPATH:603 Anatomically located instance of pathological response or entity. Pathbase: Pathology Committee Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells. mouse_pathology.ontology MPATH:604 Excludes abnormalities of developmental proliferation and differentiation. defective growth and differentiation process MPATH:604 Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells. Pathbase: Pathology Committee A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. mouse_pathology.ontology MPATH:605 Nearly exclusively used in an adult context. metaplastic tissue MPATH:605 A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. Pathbase: Pathology Committee The pathological process that results in the formation and growth of a neoplasm. mouse_pathology.ontology neoplastic process MPATH:606 Literally: new growth of cells. Neoplasia refers to the unscheduled or abnormal growth of cells, potentially resulting in a benign or malignant tumour. Neoplasms include potentially cancerous lesions as well as full malignancies but not all neoplasms are potentially cancerous. neoplasia MPATH:606 The pathological process that results in the formation and growth of a neoplasm. Pathbase: Pathology Committee neoplastic process Pathbase: Curation Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage. mouse_pathology.ontology MPATH:607 healing and repair structure MPATH:607 Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage. Pathbase: Pathology Committee A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation. mouse_pathology.ontology MPATH:608 Generally occur following damage or infection with subsequent inflammatory response. Result of the body`s defensive reaction to foreign material. abscess MPATH:608 A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation. ISBN:0781727286 Pus in a body cavity; when used without qualification, refers specifically to pyothorax. mouse_pathology.ontology MPATH:609 empyema MPATH:609 Pus in a body cavity; when used without qualification, refers specifically to pyothorax. ISBN:0781727286 Inappropriate curvature of a structure. mouse_pathology.ontology MPATH:61 curvature defect MPATH:61 Inappropriate curvature of a structure. Pathbase: Curation Dilatation of a blood vessel or valve. mouse_pathology.ontology MPATH:610 angiectasia MPATH:610 Dilatation of a blood vessel or valve. ISBN:0781727286 Acute or chronic inflammation of the tongue. mouse_pathology.ontology MPATH:611 glossitis MPATH:611 Acute or chronic inflammation of the tongue. Pathbase: Pathology Committee A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation. mouse_pathology.ontology MPATH:612 Alternately a cavity formed by liquefactive necrosis within solid tissue. Obsoleted by MPATH 608 Abscess true MPATH:612 A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation. ISBN:0781727286 Coloration, either normal or pathologic, of the skin or tissues resulting from a deposit of pigment. mouse_pathology.ontology MPATH:613 pigmentation MPATH:613 Coloration, either normal or pathologic, of the skin or tissues resulting from a deposit of pigment. ISBN:0781727286 Solid material formed by aggregation of discrete units or particles. mouse_pathology.ontology MPATH:614 concretion MPATH:614 Solid material formed by aggregation of discrete units or particles. ISBN:0781727286 A disease of the heart muscle or myocardium proper. mouse_pathology.ontology MPATH:615 Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive. cardiomyopathy MPATH:615 A disease of the heart muscle or myocardium proper. :NCI Thesaurus / A7567983 Hypertrophy of bone characterised by an abnormal increase in non-neoplastic skeletal bone mass. These may be proliferative or non-proliferative lesions. mouse_pathology.ontology osteosclerosis MPATH:616 hyperostosis MPATH:616 Hypertrophy of bone characterised by an abnormal increase in non-neoplastic skeletal bone mass. These may be proliferative or non-proliferative lesions. Long; P.H.; and Leininger; J.R ( 1999) Bones Joints and synovia; p663. in: Pathology of the Mouse. Ed Maronpot; R. Cache River Press osteosclerosis Pathbase: Curation Focal lesions of hepatocytes characterised primarily by altered cytoplasmic tinctorial properties. Classified as basophilic, eosinophilic, clear cell or mixed type. mouse_pathology.ontology Areas of cellular alteration Enzyme altered focus Focus of altered hepatocytes (fah) Hyperplastic focus Phenotypically altered focus Preneoplastic focus MPATH:617 More recently amphophilic cell foci, diffusely basophilic cell foci and vacuolated cell foci have been described. focus of cellular alteration MPATH:617 Focal lesions of hepatocytes characterised primarily by altered cytoplasmic tinctorial properties. Classified as basophilic, eosinophilic, clear cell or mixed type. Pathbase: Mohr Areas of cellular alteration Pathbase: Curation Enzyme altered focus Pathbase: Curation Focus of altered hepatocytes (fah) Pathbase: Curation Hyperplastic focus Pathbase: Curation Phenotypically altered focus Pathbase: Curation Preneoplastic focus Pathbase: Curation Hyperplasia of myeloid lineage, usually in the spleen. mouse_pathology.ontology MPATH:618 Myeloid hyperplasia ia a common diagnosis in mouse spleen. In the normal mouse spleen, a low degree of production of myeloid cells occurs (neutrophils, erythroid cells and megakaryocytes). Commonly in aging mice, due to tumors and inflammatory lesions, the mouse myeloid system in bone marrow and spleen react and become hyperplastic. In the spleen it is diagnosed as "myeloid hyperplasia" (MH), in the past it was often extramedullary hematopoiesis, which is still used by some but it is normal to a low degree in normal mouse spleen. myeloid hyperplasia MPATH:618 Hyperplasia of myeloid lineage, usually in the spleen. Pathbase: Pathology Committee Septal defect lying between the aorta and pulmonary trunks caused by failure of the spiral septum to separate the truncus arteriosus. mouse_pathology.ontology MPATH:619 truncoconal septal defect MPATH:619 Septal defect lying between the aorta and pulmonary trunks caused by failure of the spiral septum to separate the truncus arteriosus. Pathbase: Pathology Committee Formation of an epithelium bounded cavity not associated with neoplasia. mouse_pathology.ontology MPATH:62 cyst MPATH:62 Formation of an epithelium bounded cavity not associated with neoplasia. Pathbase: Pathology Committee Incomplete closure of the inter-atrial septum due to failure of the primary or secondary septum. mouse_pathology.ontology MPATH:620 inter-atrial septal defect MPATH:620 Incomplete closure of the inter-atrial septum due to failure of the primary or secondary septum. Pathbase: Curation Failure of the inter-ventricular septum to completely close between the left and right ventricles. mouse_pathology.ontology MPATH:621 inter-ventricular septal defect MPATH:621 Failure of the inter-ventricular septum to completely close between the left and right ventricles. Pathbase: Curation Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells. lipidosis mouse_pathology.ontology adipose degeneration fatty change fatty degeneration MPATH:622 Most commonly associated with degenerative change in the liver. steatosis MPATH:622 Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells. Pathbase: Curation adipose degeneration Pathbase: Curation fatty change Pathbase: Curation fatty degeneration Pathbase: Curation An adhesion, usually between the iris and the cornea or the lens capsule. mouse_pathology.ontology MPATH:623 May also be seen in the uterus ( in humans Asherman`s syndrome). synechia MPATH:623 An adhesion, usually between the iris and the cornea or the lens capsule. Millodot; Michel and Daniel Laby. Dictionary of Ophthalmology. London: Butterworth Heinemann; 2002 Turning in of the edges of a structure. mouse_pathology.ontology MPATH:624 Not return of an enlarged organ to its normal size. involution MPATH:624 Turning in of the edges of a structure. ISBN:0781727286 Tearing away or separation of two structures or parts. mouse_pathology.ontology MPATH:625 avulsion MPATH:625 Tearing away or separation of two structures or parts. ISBN:0781727286 To sink down, said of an organ or other part. A sinking of an organ or other part, especially its appearance at a natural or artificial orifice. mouse_pathology.ontology MPATH:626 prolapse MPATH:626 To sink down, said of an organ or other part. A sinking of an organ or other part, especially its appearance at a natural or artificial orifice. ISBN:0781727286 An inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells. mouse_pathology.ontology MPATH:627 pyogranulomatous inflammation MPATH:627 An inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells. Pathbase: Pathology Committee A small rounded mass of inflamed, highly vascular granulation tissue on the skin, frequently having an ulcerated surface. More likely a true neoplasm rather than a reactive lesion. mouse_pathology.ontology lobular capillary hemangioma MPATH:628 pyogenic granuloma MPATH:628 A small rounded mass of inflamed, highly vascular granulation tissue on the skin, frequently having an ulcerated surface. More likely a true neoplasm rather than a reactive lesion. Mills; S.E.; Cooper; P.H. & Fechner; R.E. (1980). Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes. Am J Surg Pathol; 4; 470-9. lobular capillary hemangioma Pathbase: Curation Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution. mouse_pathology.ontology MPATH:629 cavernous hemangioma MPATH:629 Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution. ISBN:0781727286 The removal of accumulated fluids or solids. mouse_pathology.ontology MPATH:63 depletion MPATH:63 The removal of accumulated fluids or solids. Pathbase: Pathology Committee Abnormally increased nuclear size. mouse_pathology.ontology MPATH:630 karyomegaly MPATH:630 Abnormally increased nuclear size. Pathbase: Pathology Committee Tissue or cells undergoing hypertrophy, MPATH: 159. mouse_pathology.ontology MPATH:631 hypertrophic tissue MPATH:631 Tissue or cells undergoing hypertrophy, MPATH: 159. Pathbase: Pathology Committee Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume. PMID:7943185 Hepatocellular hypertrophy. mouse_pathology.ontology MPATH:632 Hepatocytomegaly is an enlargement of the hepatocytes and is generally classified into three types: hepatocellular hypertrophy, megalocytosis, and hepatocellular vacuolation. Hepatocellular hypertrophy is an enlargement of cellular diameter without accompanying nuclear changes, leading to a net gain in the dry mass of the liver. Megalocytosis is characterized by enlargement of both the cell and the nucleus, and hepatocellular vacuolation is characterized by vacuolation, or formation of pockets of fluid within the hepatocytes. hepatocytomegaly MPATH:632 Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume. Journal: Ward; J.M.; Anver; M.R.; Haines; D.C. & Benveniste; R.E. (1994). Chronic active hepatitis in mice caused by Helicobacter hepaticus. Am J Pathol; 145; 959-68. Presence of concretions in the gallbladder or bile ducts. mouse_pathology.ontology MPATH:633 cholelithiasis MPATH:633 Presence of concretions in the gallbladder or bile ducts. ISBN:0781727286 Focal suppurative inflammation of the skin and subcutaneous tissues, enclosing a central slough or `core`. mouse_pathology.ontology Boil MPATH:634 furunculosis MPATH:634 Focal suppurative inflammation of the skin and subcutaneous tissues, enclosing a central slough or `core`. ISBN:9780702027888 Boil Pathbase: Curation Swelling of the kidneys when urine flow is obstructed in any of part of the urinary tract. Severe form of pyelectasia. mouse_pathology.ontology MPATH:635 hydronephrosis MPATH:635 Swelling of the kidneys when urine flow is obstructed in any of part of the urinary tract. Severe form of pyelectasia. ISBN:9780702027888 Inflammation of fatty tissue. mouse_pathology.ontology MPATH:636 steatitis MPATH:636 Inflammation of fatty tissue. Pathbase: Pathology Committee A retention cyst, resulting from an obstruction to the duct of a gland, within a bursa. mouse_pathology.ontology MPATH:637 bursal cyst MPATH:637 A retention cyst, resulting from an obstruction to the duct of a gland, within a bursa. Pathbase: Pathology Committee An acute, diffuse, spreading, edematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation. mouse_pathology.ontology MPATH:638 It is usually caused by infection of an operative or traumatic wound, burn or other cutaneous lesion by various bacteria, but group A streptococci and Staphylococcus aureus are the most common aetiological agents. cellulitis MPATH:638 An acute, diffuse, spreading, edematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation. URL:http://cancerweb.ncl.ac.uk/cgi-bin/omd?action=Search+OMD&query=cellulitis Accumulation of water in the ventricles of the brain. mouse_pathology.ontology MPATH:639 hydrocephalus MPATH:639 Accumulation of water in the ventricles of the brain. Pathbase: Pathology Committee Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth. mouse_pathology.ontology MPATH:64 The word dysplasia as commonly used refers to a precursor state to neoplasia. This is not the context used for this MPATH term. developmental dysplasia MPATH:64 Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth. Pathbase: Pathology Committee Deposition of organic bone matrix. mouse_pathology.ontology MPATH:640 osteoid deposition MPATH:640 Deposition of organic bone matrix. Pathbase: Pathology Committee Intradermal or subcutaneous cyst, the wall of which is stratified epithelium containing keratohyalin granules, surrounding a core of debris. mouse_pathology.ontology MPATH:641 epidermal inclusion cyst MPATH:641 Intradermal or subcutaneous cyst, the wall of which is stratified epithelium containing keratohyalin granules, surrounding a core of debris. Pathbase: Curation Intra or extracellular deposition of cholesterol. mouse_pathology.ontology MPATH:642 Often diagnosed morphologically by the presence of cholesterol clefts - bare regions of a section where accumulated cholesterol has been removed by histological processing. cholesterol deposition MPATH:642 Intra or extracellular deposition of cholesterol. Pathbase: Curation Non-cellular fluid that filters from the circulatory system and accumulates in lesions or areas of inflammation. mouse_pathology.ontology MPATH:643 serous exudate MPATH:643 Non-cellular fluid that filters from the circulatory system and accumulates in lesions or areas of inflammation. Pathbase: Pathology Committee Accumulation of chitinase-like protein. mouse_pathology.ontology MPATH:644 crystalloid formation MPATH:644 Accumulation of chitinase-like protein. Pathbase: Curation George Gkoutos 2011-03-22T03:09:08Z mouse_pathology.ontology MPATH:645 epicarditis MPATH:645 George Gkoutos 2011-03-22T03:12:07Z mouse_pathology.ontology MPATH:646 chondroarthritis MPATH:646 George Gkoutos 2011-03-22T03:14:35Z mouse_pathology.ontology MPATH:647 interstitial nephritis MPATH:647 George Gkoutos 2011-03-22T03:16:02Z mouse_pathology.ontology MPATH:648 interstitial pancreatitis MPATH:648 George Gkoutos 2011-03-22T03:16:36Z mouse_pathology.ontology MPATH:649 otitis media MPATH:649 Underdevelopment of an organ due to a decrease in the number of cells through failure to proliferate leading to lack of development. mouse_pathology.ontology MPATH:65 developmental hypoplasia true MPATH:65 Underdevelopment of an organ due to a decrease in the number of cells through failure to proliferate leading to lack of development. Pathbase: Pathology Committee George Gkoutos 2011-03-22T03:17:25Z mouse_pathology.ontology MPATH:650 proliferative dermatitis MPATH:650 George Gkoutos 2011-03-22T03:18:00Z mouse_pathology.ontology MPATH:651 ventral glossitis MPATH:651 Benign proliferation of histiocytes. George Gkoutos 2011-03-22T03:19:47Z MPATH:146 mouse_pathology.ontology MPATH:652 histiocytosis MPATH:652 Benign proliferation of histiocytes. MPATH:curation George Gkoutos 2011-03-22T03:20:12Z histiocytosis X mouse_pathology.ontology MPATH:653 langerhans cell histiocytosis MPATH:653 George Gkoutos 2011-03-22T03:20:52Z hemophagocytic syndrome mouse_pathology.ontology MPATH:654 non-Langerhans cell histiocytosis MPATH:654 George Gkoutos 2011-03-22T03:36:05Z mouse_pathology.ontology MPATH:655 lingual adenitis MPATH:655 Rupture or disruption of erythrocytes with release of contents. Paul 2011-04-01T12:08:29Z mouse_pathology.ontology MPATH:656 May be immune-mediated, induced by infectious organisms, or intrinsic disturbance of cell physiology or membrane/cytoskeletal integrity. hemolysis MPATH:656 Rupture or disruption of erythrocytes with release of contents. MPATH:Curation George Gkoutos 2011-03-22T03:45:17Z mouse_pathology.ontology MPATH:657 rhinitis MPATH:657 George Gkoutos 2011-03-22T03:45:36Z mouse_pathology.ontology MPATH:658 foreign body rhinitis MPATH:658 George Gkoutos 2011-03-22T03:46:02Z mouse_pathology.ontology MPATH:659 foreign body dermatitis MPATH:659 Increase in the diameter of an orifice or tubular structure beyond its normal dimensions. mouse_pathology.ontology MPATH:66 dilatation MPATH:66 Increase in the diameter of an orifice or tubular structure beyond its normal dimensions. Pathbase: Pathology Committee George Gkoutos 2011-03-22T03:46:42Z mouse_pathology.ontology MPATH:660 gastritis MPATH:660 George Gkoutos 2011-03-22T03:47:05Z mouse_pathology.ontology MPATH:661 foreign body gastritis MPATH:661 George Gkoutos 2011-03-22T03:47:40Z mouse_pathology.ontology MPATH:662 foreign body glossitis MPATH:662 George Gkoutos 2011-03-22T03:48:33Z mouse_pathology.ontology MPATH:663 peritonitis MPATH:663 George Gkoutos 2011-03-22T03:48:51Z mouse_pathology.ontology MPATH:664 granulomatous peritonitis MPATH:664 George Gkoutos 2011-03-22T03:49:26Z mouse_pathology.ontology MPATH:665 foreign body granulomatous peritonitis MPATH:665 George Gkoutos 2011-03-22T03:50:05Z mouse_pathology.ontology MPATH:666 periodontitis MPATH:666 George Gkoutos 2011-03-22T03:50:24Z mouse_pathology.ontology MPATH:667 foreign body periodontitis MPATH:667 George Gkoutos 2011-03-22T03:51:20Z mouse_pathology.ontology MPATH:668 tracheitis MPATH:668 George Gkoutos 2011-03-22T03:52:00Z mouse_pathology.ontology MPATH:669 foreign body tracheitis MPATH:669 Abnormal location, orientation, number, loss or non-specified deformity of a structure or tissue. mouse_pathology.ontology MPATH:67 displacement and deformity MPATH:67 Abnormal location, orientation, number, loss or non-specified deformity of a structure or tissue. Pathbase: Pathology Committee A mixed inflammatory cell infiltrate, primarily macrophages and some syncitial cells, around the heart attached to the epicardium. George Gkoutos 2011-03-22T03:52:48Z mouse_pathology.ontology MPATH:670 granulomatous epicarditis MPATH:670 A mixed inflammatory cell infiltrate, primarily macrophages and some syncitial cells, around the heart attached to the epicardium. MPATH:Sundberg George Gkoutos 2011-02-19T04:01:58Z mouse_pathology.ontology MPATH:671 mastitis MPATH:671 George Gkoutos 2011-02-19T04:05:08Z Urticaria pigmentosa mouse_pathology.ontology MPATH:672 mastocytosis MPATH:672 George Gkoutos 2011-02-19T04:06:30Z mouse_pathology.ontology MPATH:673 metritis MPATH:673 George Gkoutos 2011-02-19T04:08:00Z mouse_pathology.ontology MPATH:674 osteomyelitis MPATH:674 George Gkoutos 2011-02-19T04:09:12Z mouse_pathology.ontology MPATH:675 psoriasiform dermatitis MPATH:675 George Gkoutos 2011-02-19T04:10:14Z mouse_pathology.ontology MPATH:676 nephritis MPATH:676 George Gkoutos 2011-02-19T04:10:51Z mouse_pathology.ontology MPATH:677 pyelonephritis MPATH:677 George Gkoutos 2011-02-19T04:12:09Z mouse_pathology.ontology MPATH:678 septic nephritis MPATH:678 George Gkoutos 2011-02-19T04:12:43Z mouse_pathology.ontology MPATH:679 urocystitis MPATH:679 A blind ended outpouching through the wall of a tubular organ or bounded cavity. mouse_pathology.ontology MPATH:68 diverticulum MPATH:68 A blind ended outpouching through the wall of a tubular organ or bounded cavity. Pathbase: Curation George Gkoutos 2011-02-19T04:13:07Z mouse_pathology.ontology MPATH:680 septic urocystitis MPATH:680 George Gkoutos 2011-02-19T04:13:38Z mouse_pathology.ontology MPATH:681 septicemia MPATH:681 George Gkoutos 2011-02-19T04:15:16Z mouse_pathology.ontology MPATH:682 arteritis MPATH:682 George Gkoutos 2011-02-19T04:16:05Z mouse_pathology.ontology MPATH:683 degenerative arthritis MPATH:683 George Gkoutos 2011-02-19T04:17:26Z mouse_pathology.ontology MPATH:684 arthropathy MPATH:684 George Gkoutos 2011-02-19T04:26:34Z mouse_pathology.ontology MPATH:685 accessory organ MPATH:685 George Gkoutos 2011-02-19T04:30:20Z mouse_pathology.ontology MPATH:686 amputation MPATH:686 George Gkoutos 2011-02-19T04:30:41Z mouse_pathology.ontology MPATH:687 autoamputation MPATH:687 George Gkoutos 2011-02-19T04:34:31Z mouse_pathology.ontology MPATH:688 aortitis MPATH:688 George Gkoutos 2011-02-19T04:35:13Z mouse_pathology.ontology MPATH:689 lymphangitis MPATH:689 ectopia mouse_pathology.ontology MPATH:69 obsolete - Subsumed into heterotopia MPATH:76 ectopia true MPATH:69 ectopia Pathbase: Curation George Gkoutos 2011-02-19T04:36:16Z mouse_pathology.ontology MPATH:690 phlebitis MPATH:690 George Gkoutos 2011-02-19T04:45:08Z cutaneous abscess mouse_pathology.ontology MPATH:691 pustule MPATH:691 George Gkoutos 2011-02-19T04:56:39Z mouse_pathology.ontology MPATH:692 ulcerative blepharitis MPATH:692 George Gkoutos 2011-02-19T05:02:23Z mouse_pathology.ontology MPATH:693 pyometra MPATH:693 George Gkoutos 2011-02-19T05:05:05Z mouse_pathology.ontology MPATH:694 acidophilic anterior pituitary gland adenoma MPATH:694 George Gkoutos 2011-02-19T05:12:17Z mouse_pathology.ontology MPATH:695 spindle cell sarcoma MPATH:695 George Gkoutos 2011-02-19T05:13:13Z mouse_pathology.ontology MPATH:696 spindle cell hyperplasia MPATH:696 George Gkoutos 2011-02-19T05:17:30Z mouse_pathology.ontology MPATH:697 alopecia areata MPATH:697 George Gkoutos 2011-02-19T05:23:34Z mouse_pathology.ontology osteophytes MPATH:698 exostosis MPATH:698 George Gkoutos 2011-02-19T05:24:05Z mouse_pathology.ontology MPATH:699 ankylosing exostosis MPATH:699 A type of necrosis in which the affected cells or tissue are reduced to homogeneous eosinophilic mass without nuclear staining, as a result of the protein coagulation, eg. Infarct. Tissue architecture persists. mouse_pathology.ontology MPATH:7 coagulation necrosis MPATH:7 A type of necrosis in which the affected cells or tissue are reduced to homogeneous eosinophilic mass without nuclear staining, as a result of the protein coagulation, eg. Infarct. Tissue architecture persists. ISBN:0781727286 An abnormal passage between two internal organs or leading from a cavity to the body surface. mouse_pathology.ontology MPATH:70 fistula MPATH:70 An abnormal passage between two internal organs or leading from a cavity to the body surface. Pathbase: Curation George Gkoutos 2011-02-19T05:24:55Z mouse_pathology.ontology MPATH:700 ascites MPATH:700 George Gkoutos 2011-02-19T05:29:50Z mouse_pathology.ontology MPATH:701 developmental aspermia MPATH:701 George Gkoutos 2011-02-19T05:30:40Z mouse_pathology.ontology MPATH:702 acquired aspermia MPATH:702 George Gkoutos 2011-02-19T05:31:21Z mouse_pathology.ontology MPATH:703 developmental hypoplasia MPATH:703 George Gkoutos 2011-02-19T08:28:41Z mouse_pathology.ontology MPATH:704 thyroiditis MPATH:704 George Gkoutos 2011-02-19T10:33:51Z mouse_pathology.ontology MPATH:705 acinar atrophy MPATH:705 George Gkoutos 2011-02-19T10:37:34Z mouse_pathology.ontology MPATH:706 cryptorchidism MPATH:706 George Gkoutos 2011-02-20T08:44:41Z mouse_pathology.ontology MPATH:707 angiolipoma MPATH:707 Distension of the renal pelvis by accumulated fluid or urine. Paul 2011-06-06T03:01:54Z mouse_pathology.ontology MPATH:708 May be fetal or adult. pyelectasia MPATH:708 Distension of the renal pelvis by accumulated fluid or urine. : Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation. Paul 2011-06-06T03:24:13Z mouse_pathology.ontology MPATH:709 alveolar rhabdomyosarcoma MPATH:709 Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation. ICD-O:8920/3 Failure of two or more structures ( not voids or lumens) to join together. mouse_pathology.ontology MPATH:71 fusion process defect MPATH:71 Failure of two or more structures ( not voids or lumens) to join together. ISBN:0781727286 Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle. Paul 2011-06-06T03:31:11Z Myosarcoma mouse_pathology.ontology Rhabdopoietic Sarcoma Sarcoma Botryoides [Soft Tissues] Embryonal Sarcoma Malignant Rhabdomyoma MPATH:710 Includes spindle cell, botryoid, anaplastic. embryonal rhabdomyosarcoma MPATH:710 Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle. ICD-O:8910/3 ICDO-:8912/3 George Gkoutos 2011-02-20T12:06:02Z mouse_pathology.ontology MPATH:711 situs ambiguus MPATH:711 George Gkoutos 2011-02-20T12:06:38Z mouse_pathology.ontology MPATH:712 heterotaxy MPATH:712 George Gkoutos 2011-02-20T12:07:15Z mouse_pathology.ontology situs inversus with dextrocardia MPATH:713 situs ambiguus totalis MPATH:713 George Gkoutos 2011-02-20T12:08:14Z mouse_pathology.ontology MPATH:714 situs inversus with levocardia MPATH:714 George Gkoutos 2011-02-20T12:10:00Z mouse_pathology.ontology MPATH:715 sinusitis MPATH:715 George Gkoutos 2011-02-20T12:14:20Z mouse_pathology.ontology primary ciliary dyskinesis MPATH:716 ciliary motility defect MPATH:716 George Gkoutos 2011-02-20T02:28:51Z mouse_pathology.ontology MPATH:717 Most often used in the context of bone. sequestrum MPATH:717 Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine. Paul 2011-06-06T03:39:01Z mouse_pathology.ontology MPATH:718 pre-sacral teratoma MPATH:718 Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine. : George Gkoutos 2011-02-20T12:04:36Z mouse_pathology.ontology MPATH:719 bronchiectasia MPATH:719 Increase in the rate of growth of an organism, organ or tissue as a consequence of increased proliferation, reduced cell death, or a combination. Not due to an increase in cell size; see Hypertrophy MPATH: 159. mouse_pathology.ontology MPATH:72 growth acceleration MPATH:72 Increase in the rate of growth of an organism, organ or tissue as a consequence of increased proliferation, reduced cell death, or a combination. Not due to an increase in cell size; see Hypertrophy MPATH: 159. Pathbase: Pathology Committee George Gkoutos 2011-02-20T12:05:38Z mouse_pathology.ontology MPATH:720 situs inversus MPATH:720 Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Sacrococcygeal tumors are located at the base of the coccyx. Paul 2011-06-06T03:51:12Z mouse_pathology.ontology MPATH:721 sacrococcygeal teratoma MPATH:721 Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Sacrococcygeal tumors are located at the base of the coccyx. : Benign stromal tumors of the soft tissue with skeletal muscle differentiation. Paul 2011-06-06T03:59:49Z mouse_pathology.ontology MPATH:722 Adult and fetal types. rhabdomyoma MPATH:722 Benign stromal tumors of the soft tissue with skeletal muscle differentiation. ICD-O:M-8900/0 PMID:3525381 Systemic manifestation of MPATH: 407. Paul 2011-06-06T04:11:04Z Desmoid Tumor mouse_pathology.ontology Musculoaponeurotic Fibromatosis Aggressive Fibromatosis Plantar Fibromatosis (Ledderhose Disease) MPATH:723 fibromatosis MPATH:723 Systemic manifestation of MPATH: 407. ICDO:M-8822/1 Dermal, subcutaneous, or tendinous lesions characterized by accumulations of lipid-laden macrophages often rich in cholesterol. Paul 2011-06-08T03:43:07Z mouse_pathology.ontology MPATH:724 xanthoma MPATH:724 Dermal, subcutaneous, or tendinous lesions characterized by accumulations of lipid-laden macrophages often rich in cholesterol. MPATH:Pathology Committee Paul 2011-10-26T02:02:02Z mouse_pathology.ontology MPATH:725 chronic interstitial nephritis MPATH:725 Paul 2011-10-26T02:05:04Z mouse_pathology.ontology MPATH:726 hemosiderosis MPATH:726 Paul 2011-10-26T02:05:29Z mouse_pathology.ontology MPATH:727 hepatic hemosiderosis MPATH:727 Paul 2011-10-26T02:06:12Z mouse_pathology.ontology MPATH:728 pulmonary hemosiderosis MPATH:728 Paul 2011-10-26T02:06:46Z mouse_pathology.ontology MPATH:729 splenic melanosis MPATH:729 The cessation of fetal or embryonic growth beyond a particular stage. mouse_pathology.ontology MPATH:73 growth arrest MPATH:73 The cessation of fetal or embryonic growth beyond a particular stage. Pathbase: Pathology Committee Paul 2011-10-26T02:13:35Z mouse_pathology.ontology MPATH:730 renal tubular concretion MPATH:730 Paul 2011-10-26T02:17:02Z mouse_pathology.ontology MPATH:731 Leydig cell hyperplasia MPATH:731 Paul 2011-10-26T02:19:12Z mouse_pathology.ontology MPATH:732 tracheal gland ectasia MPATH:732 A uterus distended with a fluid containing large quantities of mucin. Paul 2011-10-26T02:22:56Z mouse_pathology.ontology MPATH:733 mucometra MPATH:733 A uterus distended with a fluid containing large quantities of mucin. MPATH:Sundberg Paul 2011-10-26T02:23:54Z mouse_pathology.ontology MPATH:734 acute blepharitis MPATH:734 Thickening of the cementum layer of the molars. Paul 2011-10-26T02:25:55Z mouse_pathology.ontology MPATH:735 This is usually a normal adaptive response, serving to improve the functional properties of teeth during aging. molar hypercementosis MPATH:735 Thickening of the cementum layer of the molars. MPATH:Sundberg Paul 2011-10-26T02:29:29Z mouse_pathology.ontology MPATH:736 A variety of cysts develop in the ovary. They are subdivided based on where they develop anatomically. Ovarian follicles in this case become large and fluid filled. ovarian follicular cyst MPATH:736 Paul 2011-10-26T02:33:06Z mouse_pathology.ontology MPATH:737 Usually rd6-outer retinal photoreceptor degeneration retinal degeneration MPATH:737 Paul 2011-10-26T02:34:35Z mouse_pathology.ontology MPATH:738 The uterus of older female mice often becomes distended with numerous fluid filled cysts that extend from the endometrium. uterine cystic endometrial hyperplasia MPATH:738 Extravascular blood between retina and choroid Paul 2011-10-26T02:36:03Z mouse_pathology.ontology MPATH:739 sub-retinal hemorrhage MPATH:739 Extravascular blood between retina and choroid MPATH:Sundberg A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477. mouse_pathology.ontology MPATH:74 hamartoma MPATH:74 A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477. ISBN:0781727286 Tiny yellow or white deposits of lamellar or amorphous extracellular material that build up between retina and retinal pigment epithelium. Paul 2011-10-26T02:38:14Z mouse_pathology.ontology MPATH:740 drusen MPATH:740 Tiny yellow or white deposits of lamellar or amorphous extracellular material that build up between retina and retinal pigment epithelium. MPATH:Sundberg An increase in size of the spleen. Paul 2011-10-26T02:56:13Z mouse_pathology.ontology MPATH:741 splenomegaly MPATH:741 An increase in size of the spleen. MPATH:Sundberg Rupture of the intervertebral disc, usually dorsally to compress the spinal cord, secondary to trauma. Paul 2011-10-26T02:59:08Z mouse_pathology.ontology MPATH:742 These become more common with age. intervertebral disk prolapse MPATH:742 Rupture of the intervertebral disc, usually dorsally to compress the spinal cord, secondary to trauma. MPATH:Sundberg Accumulation of clear large vacuoles in hepatocytes (most likely lipid pending frozen sections and oil red O or other lipid stains) around central veins. Paul 2011-10-26T03:04:08Z mouse_pathology.ontology MPATH:743 hepatic centrolobular fatty metamorphosis MPATH:743 Accumulation of clear large vacuoles in hepatocytes (most likely lipid pending frozen sections and oil red O or other lipid stains) around central veins. MPATH:Sundberg Release of melanin pigment in the dermis. Paul 2011-10-26T03:06:29Z mouse_pathology.ontology MPATH:744 Observed as melanin pigment within macrophages in the dermis. Inflammation in the epidermis stimulates melanocytes to increase the synthesis of melanin and subsequently to transfer the pigment to surrounding keratinocytes. If the basal layer is injured (e.g. lichen planus), melanin pigment is released and subsequently trapped by macrophages in the papillary dermis. pigmentary incontinence MPATH:744 Release of melanin pigment in the dermis. MPATH:Sundberg Degenerative changes in skeletal muscle including hyalinization, swelling, fragmentation, vacuolation eventually resulting in death of muscle fibers. Paul 2011-10-26T03:15:56Z mouse_pathology.ontology MPATH:745 zenker's necrosis MPATH:745 Degenerative changes in skeletal muscle including hyalinization, swelling, fragmentation, vacuolation eventually resulting in death of muscle fibers. MPATH:Sundberg Fragmentation and erosion of articular cartilage. Paul 2011-10-26T03:18:38Z mouse_pathology.ontology MPATH:746 cartilagenous erosion MPATH:746 Fragmentation and erosion of articular cartilage. MPATH::Sundberg Pink amorphous material (amyloid) deposited within the renal tubules. Paul 2011-10-26T03:34:30Z mouse_pathology.ontology MPATH:747 renal tubular amyloidosis MPATH:747 Pink amorphous material (amyloid) deposited within the renal tubules. MPATH:Sundberg An old organized thrombus that has been recanalized to permit blood flow. Paul 2011-10-26T03:36:06Z mouse_pathology.ontology MPATH:748 recanalised thrombus MPATH:748 An old organized thrombus that has been recanalized to permit blood flow. MPATH:Sundberg Various degrees of pulmonary interstitial fibrosis. Paul 2011-10-26T03:37:48Z mouse_pathology.ontology MPATH:749 focal pulmonary fibrosis MPATH:749 Various degrees of pulmonary interstitial fibrosis. MPATH:Sundberg Protrusion of a loop or wall of an organ through an abnormal opening. mouse_pathology.ontology MPATH:75 hernia MPATH:75 Protrusion of a loop or wall of an organ through an abnormal opening. Pathbase: Curation Neoplastic proliferation of cuboidal cells lining alveoli most likely type II pneumocytes. Paul 2011-10-26T03:40:09Z mouse_pathology.ontology MPATH:750 pulmonary adenomatosis MPATH:750 Neoplastic proliferation of cuboidal cells lining alveoli most likely type II pneumocytes. MPATH:Sundberg Free pigment in anterior chamber/elsewhere in eye. Paul 2011-10-26T03:41:56Z mouse_pathology.ontology MPATH:751 pigment dispersion MPATH:751 Free pigment in anterior chamber/elsewhere in eye. MPATH:Sundberg loss of hair resulting from a behavioral abnormality in which the mouse, or more often other mice mice in the same box, remove hairs, initially vibrissae, from each other. Paul 2011-10-26T03:44:05Z mouse_pathology.ontology MPATH:752 This is a form of trichotillomania. barbered MPATH:752 loss of hair resulting from a behavioral abnormality in which the mouse, or more often other mice mice in the same box, remove hairs, initially vibrissae, from each other. MPATH:Sundberg The forestomach of the mouse is lined by stratified squamous epithelia. At the limiting ridge there is hyperplasia to various degrees in which this epithelium proliferates to form raised areas on thin fibrovascular stalks. Paul 2011-10-26T03:47:01Z mouse_pathology.ontology MPATH:753 gastric forestomach papillomatous hyperplasia MPATH:753 The forestomach of the mouse is lined by stratified squamous epithelia. At the limiting ridge there is hyperplasia to various degrees in which this epithelium proliferates to form raised areas on thin fibrovascular stalks. MPATH:Sundberg Spleen contains foci of macrophages containing yellow brown pigment that is positive for iron using Prussian blue. Paul 2011-11-02T03:30:56Z mouse_pathology.ontology MPATH:754 splenic hemosiderosis MPATH:754 Spleen contains foci of macrophages containing yellow brown pigment that is positive for iron using Prussian blue. MPATH:Sundberg Small foci of mineralization within the interstitium between alveoli. Paul 2011-11-02T03:33:11Z mouse_pathology.ontology MPATH:755 pulmonary interstitial mineralisation MPATH:755 Small foci of mineralization within the interstitium between alveoli. MPATH:Sundberg Chronic inflammation in and around small and medium sized arteries, often in more than one location. Paul 2011-11-02T03:41:52Z mouse_pathology.ontology Kussmaul disease Kussmaul-Maier disease MPATH:756 polyarteritis nodosa MPATH:756 Chronic inflammation in and around small and medium sized arteries, often in more than one location. MPATH:Sundberg Foci of mineralization within the interstitium of a tissue. Paul 2011-11-02T03:54:07Z mouse_pathology.ontology MPATH:757 interstitial mineralization MPATH:757 Foci of mineralization within the interstitium of a tissue. MPATH:Sundberg Small foci of mineralization within the interstitium between tubules. Paul 2011-11-02T03:57:16Z mouse_pathology.ontology MPATH:758 renal interstitial mineralisation MPATH:758 Small foci of mineralization within the interstitium between tubules. MPATH:Sundberg Appearance of clinical and/or subclinical signs and symptoms associated with pregnancy when the animal is not pregnant Paul 2011-11-02T04:02:14Z false pregnancy mouse_pathology.ontology MPATH:759 Virgin females have mammary acini and ducts dilated to various degrees filled with proteinaceous materials suggestive of lactation or involution. pseudocyesis MPATH:759 Appearance of clinical and/or subclinical signs and symptoms associated with pregnancy when the animal is not pregnant MPATH:Sundberg Congenital appearance of a body part or tissue or cell type in a region where it is not normally found ( topographical anomaly). mouse_pathology.ontology Ectopia MPATH:76 heterotopia MPATH:76 Congenital appearance of a body part or tissue or cell type in a region where it is not normally found ( topographical anomaly). Pathbase: Pathology Committee Ectopia Pathbase: Curation Marked dilatation of the ovarian bursa. Paul 2011-11-02T04:07:28Z mouse_pathology.ontology MPATH:760 May compress the ovary ovarian bursal cyst MPATH:760 Marked dilatation of the ovarian bursa. MPATH:Sundberg Linear palisaiding of nuclei within thin pale muscle fibers suggestive of repair. Paul 2011-11-02T04:14:39Z mouse_pathology.ontology MPATH:761 muscle regeneration MPATH:761 Linear palisaiding of nuclei within thin pale muscle fibers suggestive of repair. MPATH:Sundberg Thyroid gland follicles are filled with colloid but vary greatly in size. Paul 2011-11-02T04:18:38Z mouse_pathology.ontology MPATH:762 Suggestive of goiter or other functional abnormality. thyroid follicle pleomorphism MPATH:762 Thyroid gland follicles are filled with colloid but vary greatly in size. MPATH:Sundberg Salivary gland duct occlusion resulting in massive enlargement forming a large cyst-like structure. Paul 2011-11-02T04:23:20Z mouse_pathology.ontology MPATH:763 sialocele MPATH:763 Salivary gland duct occlusion resulting in massive enlargement forming a large cyst-like structure. MPATH:Sundberg A fracture is the (local) separation of a bone into two, or more, pieces under the action of stress. Paul 2011-11-02T04:29:57Z mouse_pathology.ontology MPATH:764 fracture MPATH:764 A fracture is the (local) separation of a bone into two, or more, pieces under the action of stress. MPATH:PNS Break in bone associated with exostoses. Paul 2011-11-02T04:34:27Z mouse_pathology.ontology MPATH:765 fracture and healing MPATH:765 Break in bone associated with exostoses. MPATH:Sundberg The lamina propria is distended with amorphous hyalinized material interpreted to be amyloid protein. Paul 2011-11-02T06:59:37Z mouse_pathology.ontology MPATH:766 intestinal amyloidosis MPATH:766 The lamina propria is distended with amorphous hyalinized material interpreted to be amyloid protein. MPATH:Sundberg A Meckel's diverticulum is a pouch on the wall of the lower part of the intestine that is present at birth. Paul 2011-11-02T07:05:54Z mouse_pathology.ontology MPATH:767 Meckel's diverticulum MPATH:767 A Meckel's diverticulum is a pouch on the wall of the lower part of the intestine that is present at birth. PMH:0001281 Necrosis associated with or caused by local bacterial infection. Paul 2011-11-02T07:11:40Z mouse_pathology.ontology MPATH:768 septic necrosis MPATH:768 Necrosis associated with or caused by local bacterial infection. MPATH:Sundberg Necrosis of the uterine wall with large bacterial colonies on its surface. Paul 2011-11-02T07:15:32Z mouse_pathology.ontology MPATH:769 uterine septic necrosis MPATH:769 Necrosis of the uterine wall with large bacterial colonies on its surface. MPATH:Sundberg Stricto sensu: replacement of one body part or tissue by an homologous structure or tissue, but commonly used incorrectly to describe non-homologous transformations better described as heterotopias or ectopias. mouse_pathology.ontology MPATH:77 homoeotic change MPATH:77 Stricto sensu: replacement of one body part or tissue by an homologous structure or tissue, but commonly used incorrectly to describe non-homologous transformations better described as heterotopias or ectopias. Pathbase: Pathology Committee Abnormal organ dimensions or weight Paul 2011-11-02T07:19:32Z mouse_pathology.ontology MPATH:770 abnormal organ size MPATH:770 Abnormal organ dimensions or weight MPATH:<new dbxref> MPATH:PNS Abnormality of extent of the normal long axis Paul 2011-11-02T07:21:06Z mouse_pathology.ontology MPATH:771 abnormal organ length MPATH:771 Abnormality of extent of the normal long axis MPATH:<new dbxref> MPATH:PNS Abnormal mass of organ Paul 2011-11-02T07:22:00Z mouse_pathology.ontology MPATH:772 abnormal organ mass MPATH:772 Abnormal mass of organ MPATH:<new dbxref> MPATH:PNS Abnormal length of the intestine. Paul 2011-11-02T07:22:44Z mouse_pathology.ontology MPATH:773 abnormal intestine length MPATH:773 Abnormal length of the intestine. MPATH:PNS Focal necrosis in the liver often but not always associated with thrombosis. Paul 2011-11-02T07:24:44Z mouse_pathology.ontology MPATH:774 focal hepatic coagulative necrosis MPATH:774 Focal necrosis in the liver often but not always associated with thrombosis. MPATH:Sundberg Exertion of abnormal force on a structure or structures usually resulting in deformation and damage. Paul 2011-11-02T07:27:38Z mouse_pathology.ontology MPATH:775 compression MPATH:775 Exertion of abnormal force on a structure or structures usually resulting in deformation and damage. MPATH:PNS mpath:<new dbxref> A spermatocoele is a cyst that contains spermatozoa. . Paul 2011-11-02T07:30:33Z mouse_pathology.ontology MPATH:776 They occur in the head of the epididymis or less commonly, in the spermatic cord. spermatocoele MPATH:776 A spermatocoele is a cyst that contains spermatozoa. . MPATH:PNS Formation of urinary concretions in any part of the kidney. Paul 2011-11-02T07:32:55Z mouse_pathology.ontology MPATH:777 urelithiasis MPATH:777 Formation of urinary concretions in any part of the kidney. MPATH:PNS https://doi.org/10.1038/srep41807 Paul 2011-11-02T07:34:59Z mouse_pathology.ontology MPATH:778 corpora amylacea MPATH:778 https://doi.org/10.1038/srep41807 MPATH:PNS Formation or urinary concretions in the ureter. Paul 2011-11-02T07:36:04Z mouse_pathology.ontology MPATH:779 uretolithiasis MPATH:779 Formation or urinary concretions in the ureter. MPATH:PNS Incomplete closure of a void or lumen due to failure of growth or fusion of bounding walls. mouse_pathology.ontology MPATH:78 incomplete closure MPATH:78 Incomplete closure of a void or lumen due to failure of growth or fusion of bounding walls. Pathbase: Pathology Committee Pseudoxanthoma elasticum is a progressive disorder characterized by accumulated deposits of calcium and other minerals in elastic fibers. Paul 2011-11-02T07:38:35Z mouse_pathology.ontology MPATH:780 pseudoxanthoma elasticum MPATH:780 Pseudoxanthoma elasticum is a progressive disorder characterized by accumulated deposits of calcium and other minerals in elastic fibers. MPATH:PNS Softening of brain tissue, usually caused by vascular insufficiency or degenerative changes. Paul 2011-11-02T07:43:13Z cerebromalacia mouse_pathology.ontology MPATH:781 Areas in the brain where the parenchyma is blanched. Cells in this area are pycnotic. This may be the sequela of an infarction. encephalomalacia MPATH:781 Softening of brain tissue, usually caused by vascular insufficiency or degenerative changes. MPATH:PNS Collapse of the eye globe associated with degenerative changes. Paul 2011-11-02T07:51:11Z mouse_pathology.ontology MPATH:782 phthisis bulbi MPATH:782 Collapse of the eye globe associated with degenerative changes. MPATH:Sundberg Follicular dystrophy, rupture, foreign body reaction, ulceration, scarring, pseudoepitheliomatous hyperplasia are part of a syndrome commonly called B6 dermatitis in black strains of mice. Paul 2011-11-02T07:55:07Z mouse_pathology.ontology MPATH:783 B6 dermatitis MPATH:783 Follicular dystrophy, rupture, foreign body reaction, ulceration, scarring, pseudoepitheliomatous hyperplasia are part of a syndrome commonly called B6 dermatitis in black strains of mice. MPATH:Sundberg Degeneration and resorption of an ovarian follicle before it reaches maturity and ruptures. Paul 2011-11-02T07:59:53Z mouse_pathology.ontology MPATH:784 Included here to permit annotation of unusual patterns or atresia; abnormal numbers of atretic follicles or abnoral size or distribution. follicular atresia MPATH:784 Degeneration and resorption of an ovarian follicle before it reaches maturity and ruptures. MPATH:PNS Marked production of granulocytes, primarily neutrophils, usually in response to a major acute inflammatory response. Paul 2011-11-02T08:06:16Z mouse_pathology.ontology MPATH:785 bone marrow granulopoiesis MPATH:785 Marked production of granulocytes, primarily neutrophils, usually in response to a major acute inflammatory response. MPATH:Sundberg The drying, thickening and coagulation of extracellular secretions or fluids. Paul 2011-11-02T08:09:33Z mouse_pathology.ontology MPATH:786 inspissation MPATH:786 The drying, thickening and coagulation of extracellular secretions or fluids. MPATH:PNS Ventral prolapse of the intervertebral disk. Paul 2011-11-02T08:37:59Z mouse_pathology.ontology MPATH:787 Ventral prolapse is quite rare but found in ageing mice. intervertebral disk prolapse ventral MPATH:787 Ventral prolapse of the intervertebral disk. MPATH:Sundberg The testicle twisted around the vascular tract to constrict flow resulting in liquifactive necrosis of the affected testicle. Paul 2011-11-02T08:43:39Z mouse_pathology.ontology MPATH:788 testicular torsion MPATH:788 The testicle twisted around the vascular tract to constrict flow resulting in liquifactive necrosis of the affected testicle. MPATH:Sundberg Dermal granuloma surrounding hair fibers. Paul 2011-11-02T08:52:38Z mouse_pathology.ontology MPATH:789 trichogranuloma MPATH:789 Dermal granuloma surrounding hair fibers. MPATH:Sundberg Abnormal position or orientation of a structure insufficient to be called a heterotopia. mouse_pathology.ontology Misplacement MPATH:79 malposition MPATH:79 Abnormal position or orientation of a structure insufficient to be called a heterotopia. Pathbase: Curation Misplacement Pathbase: Curation Retinal degeneration of both eyes. Paul 2011-11-02T08:56:45Z mouse_pathology.ontology MPATH:790 bilateral retinal degeneration MPATH:790 Retinal degeneration of both eyes. MPATH:Sundberg Occlusion of a vessel by a piece of dissected cartilage. Paul 2011-11-02T09:27:08Z mouse_pathology.ontology MPATH:791 cartilagenous embolism MPATH:791 Occlusion of a vessel by a piece of dissected cartilage. MPATH:Sundberg Proliferation of the reticuloendothelial cells in the medulla of the lymph node. Paul 2011-11-02T09:32:12Z mouse_pathology.ontology MPATH:792 lymph node reticuloendothelial cell hyperplasia MPATH:792 Proliferation of the reticuloendothelial cells in the medulla of the lymph node. MPATH:Sundberg An increase in the size of the spleen due to ongoing acute or chronic infection. Paul 2011-11-02T09:42:26Z mouse_pathology.ontology MPATH:793 reactive splenomegaly MPATH:793 An increase in the size of the spleen due to ongoing acute or chronic infection. MPATH:Sundberg Digested blood in the lumen of the stomach or small intestine, indicative of hemorrhage. Paul 2011-11-02T09:57:01Z mouse_pathology.ontology MPATH:794 melena MPATH:794 Digested blood in the lumen of the stomach or small intestine, indicative of hemorrhage. MPATH:Sundberg Round , often laminar, non-proteinaceous eosinophilic bodies representing calcium deposition. Paul 2011-11-02T10:01:09Z mouse_pathology.ontology MPATH:795 Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from (1) the infarction and calcification of papillae tips and (2) calcification of intralymphatic tumor thrombi. psammoma body MPATH:795 Round , often laminar, non-proteinaceous eosinophilic bodies representing calcium deposition. MPATH:Sundberg Lack of sperm. Paul 2011-11-02T10:10:45Z mouse_pathology.ontology MPATH:796 May be through failure of spermatogenesis, or increased death. aspermia MPATH:796 Lack of sperm. MPATH:Sundberg Compromise or abnormality of the process of spermatogenesis Paul 2011-11-02T10:17:11Z mouse_pathology.ontology MPATH:797 spermatogenesis defect MPATH:797 Compromise or abnormality of the process of spermatogenesis MPATH:PNS Reduced numbers of sperm. Paul 2011-11-02T10:18:26Z mouse_pathology.ontology MPATH:798 hypospermia MPATH:798 Reduced numbers of sperm. MPATH:PNS scoliosis is an abnormal curvature of the spine. The spine curves away from the middle or sideways. Paul 2011-11-02T10:20:56Z mouse_pathology.ontology MPATH:799 scoliosis MPATH:799 scoliosis is an abnormal curvature of the spine. The spine curves away from the middle or sideways. MPATH:Sundberg Dead and dying adipose tissue, characterized by the formation of small gray or white foci of soapy (saponified) cellular debris. mouse_pathology.ontology MPATH:8 fat necrosis MPATH:8 Dead and dying adipose tissue, characterized by the formation of small gray or white foci of soapy (saponified) cellular debris. ISBN:0781727286 Occlusion ( partial or complete) of a lumen or space, internally by a space occupying mass or, in the case of stenosis, by local reduction in the diameter of a vessel, duct or the intestine. mouse_pathology.ontology MPATH:80 obstruction and stenosis MPATH:80 Occlusion ( partial or complete) of a lumen or space, internally by a space occupying mass or, in the case of stenosis, by local reduction in the diameter of a vessel, duct or the intestine. Pathbase: Pathology Committee Dorsal prolapse of the intervertebral disk. Paul 2011-11-03T07:08:38Z mouse_pathology.ontology MPATH:800 intervertebral disk prolapse dorsal MPATH:800 Dorsal prolapse of the intervertebral disk. MPATH:Sundberg Presence of dorsal and ventrally prolapsed disks in the same vertebral column. Paul 2011-11-03T07:09:46Z mouse_pathology.ontology MPATH:801 intervertebral disks prolapsed dorsally and ventrally MPATH:801 Presence of dorsal and ventrally prolapsed disks in the same vertebral column. MPATH:Sundberg Eversion through the anus. Paul 2011-11-03T07:11:38Z mouse_pathology.ontology MPATH:802 rectal prolapse MPATH:802 Eversion through the anus. MPATH:Sundberg Thickening of trabecular bone. Paul 2011-11-03T07:41:18Z mouse_pathology.ontology MPATH:803 Not osteopetrosis. trabecular bone thickening MPATH:803 Thickening of trabecular bone. MPATH:Sundberg Large numbers of thin-walled dilated lymphatic channels situated in the dermis, subcutis or skeletal muscle. Paul 2011-11-25T03:58:53Z mouse_pathology.ontology MPATH:804 This is a developmental malformation cavernous lymphangioma MPATH:804 Large numbers of thin-walled dilated lymphatic channels situated in the dermis, subcutis or skeletal muscle. ISBN:0-19-261976-4 Variant of cavernous lymphangioma (MPATH:804) showing gross dilatation of lymphatic channels. Paul 2011-11-25T04:01:26Z mouse_pathology.ontology Cystic lymphangioma. MPATH:805 cystic hygroma MPATH:805 Variant of cavernous lymphangioma (MPATH:804) showing gross dilatation of lymphatic channels. ISBN:0-19-261976-4 Cutaneous grouped collection of thin-walled translucent vessels, which appear at birth or in early infancy and are commonest around the limb girdles. Paul 2011-11-25T04:03:31Z mouse_pathology.ontology MPATH:806 Generally believed to represent a developmental defect but may be associated with surgery. lymphangioma circumscriptum MPATH:806 Cutaneous grouped collection of thin-walled translucent vessels, which appear at birth or in early infancy and are commonest around the limb girdles. ISBN:0-19-261976-4 Large cystic subcutaneous spaces usually found in the flexures, especially around the neck. Paul 2011-11-25T04:11:06Z mouse_pathology.ontology Cystic hygroma MPATH:807 Obstruction of the developing lymphatics may contribute to their genesis. hygroma MPATH:807 Large cystic subcutaneous spaces usually found in the flexures, especially around the neck. ISBN:0-19-261976-4 Accumulation of interstitial fluid caused by blockage or failure of the lymphatic system. Paul 2011-11-25T04:15:32Z Lymphoedema mouse_pathology.ontology MPATH:808 Not be confused with edema arising from venous insufficiency, which is not lymphedema. lymphedema MPATH:808 Accumulation of interstitial fluid caused by blockage or failure of the lymphatic system. ISBN:0-19-261976-4 Edema of the posterior aspect of the fetal neck caused by an accumulation of fluid, usually lymph. Paul 2011-11-25T04:33:15Z mouse_pathology.ontology MPATH:809 nuchal edema MPATH:809 Edema of the posterior aspect of the fetal neck caused by an accumulation of fluid, usually lymph. MPATH:Pathology committee Presence of a hole/channel through a normally imperforate structure often a membrane or septum. mouse_pathology.ontology MPATH:81 perforation MPATH:81 Presence of a hole/channel through a normally imperforate structure often a membrane or septum. Pathbase: Pathology Committee Degenerative changes in hair follicles resulting in a deformed hair fiber, sometimes root sheath hyperplasia and follicular rupture. Paul 2011-11-25T05:04:59Z mouse_pathology.ontology MPATH:810 follicular dystrophy MPATH:810 Degenerative changes in hair follicles resulting in a deformed hair fiber, sometimes root sheath hyperplasia and follicular rupture. MPATH:Sundberg Deposition of minerals in the epicardium. Paul 2012-03-19T03:53:35Z mouse_pathology.ontology MPATH:811 epicardial mineralization MPATH:811 Deposition of minerals in the epicardium. MPATH:curation A collection of fluid underneath the top layer of skin (epidermis). Paul 2012-03-19T03:59:12Z mouse_pathology.ontology MPATH:812 Most blisters are filled with a clear fluid called serum or plasma. However, blisters can be filled with blood (known as blood blisters) or with pus (if they become infected). blister MPATH:812 A collection of fluid underneath the top layer of skin (epidermis). MPATH:curation Lesions of a connective tissue disease causing blisters in the skin and mucosal membranes. Paul 2012-03-19T04:02:20Z mouse_pathology.ontology MPATH:813 epidermolysis bullosa lesions MPATH:813 Lesions of a connective tissue disease causing blisters in the skin and mucosal membranes. MPATH:curation Locally circumscribed regions of fatty change. Paul 2012-03-19T04:10:23Z focal fatty change mouse_pathology.ontology MPATH:814 focal hepatic lipidosis MPATH:814 Locally circumscribed regions of fatty change. MPATH:curation subtype of steatosis with Hepatocytes containing a large well-defined single rounded vacuole within each cell, nucleus and cytoplasm displaced to the periphery, Paul 2012-03-19T04:13:31Z macrovesicular steatosis mouse_pathology.ontology MPATH:815 macrovesicular lipidosis MPATH:815 subtype of steatosis with Hepatocytes containing a large well-defined single rounded vacuole within each cell, nucleus and cytoplasm displaced to the periphery, PMID:21191096 Variant form of hepatic steatosis. Hepatocytes partially or completely filled with numerous small lipid vacuoles. Affected hepatocytes may have a foamy appearance.Small vacuoles do not normally displace the nucleus to the periphery in contrast to macrovesicular lipidosis. Paul 2012-03-19T04:18:42Z microvesicular fatty change microvesicular steatosis mouse_pathology.ontology MPATH:816 microvesicular lipidosis MPATH:816 Variant form of hepatic steatosis. Hepatocytes partially or completely filled with numerous small lipid vacuoles. Affected hepatocytes may have a foamy appearance.Small vacuoles do not normally displace the nucleus to the periphery in contrast to macrovesicular lipidosis. PMID:21191096 Form of degenerative process in which there is Intracytoplasmic fluid accumulation secondary to disturbance of cell membrane integrity. Paul 2012-03-19T04:26:38Z cloudy swelling hydropic change mouse_pathology.ontology <new synonym> MPATH:817 Cytoplasmic vacuolation and ballooning with a centrally located nucleus. hydropic degeneration MPATH:817 Form of degenerative process in which there is Intracytoplasmic fluid accumulation secondary to disturbance of cell membrane integrity. MPATH:curation Paul 2012-03-19T04:37:02Z mouse_pathology.ontology MPATH:818 focal pulmonary histiocytosis MPATH:818 Paul 2012-03-19T04:39:04Z mouse_pathology.ontology MPATH:819 focal renal pelvic mineralisation. MPATH:819 Persistence of an embryonic structure or tissue into the post-natal period in its normal location; (Chronological/temporal anomaly). mouse_pathology.ontology Embryonic rest. MPATH:82 persistent embryonic structure MPATH:82 Persistence of an embryonic structure or tissue into the post-natal period in its normal location; (Chronological/temporal anomaly). Pathbase: Pathology Committee Embryonic rest. Pathbase: Curation Increase in size of the thyroid gland caused initially by uniform follicular epithelial hyperplasia generally in response to iodine deficiency. Paul 2012-03-19T05:09:58Z goiter mouse_pathology.ontology hyperplastic goitre MPATH:820 goitre MPATH:820 Increase in size of the thyroid gland caused initially by uniform follicular epithelial hyperplasia generally in response to iodine deficiency. MPATH:curation Tissue showing smaller mass as a consequence of deficient proliferation or premature differentiation. Paul 2012-03-19T05:20:21Z mouse_pathology.ontology MPATH:821 hypoplastic tissue MPATH:821 Tissue showing smaller mass as a consequence of deficient proliferation or premature differentiation. MPATH:curation Reduced mass of GALT resulting form fewer cells. Paul 2012-03-19T05:21:50Z mouse_pathology.ontology MPATH:822 hypoplastic gut associated lymphoid tissue MPATH:822 Reduced mass of GALT resulting form fewer cells. MPATH:curation A benign neoplasm characterized by mucous and fibroblastic tissues. Paul 2012-03-20T11:45:41Z Fibromyxoma mouse_pathology.ontology fibroma myxomatodes. MPATH:823 myxofibroma MPATH:823 A benign neoplasm characterized by mucous and fibroblastic tissues. MPATH:curation A benign localized neoplasm arising from the subcutaneous tissues and skeletal muscle. It is characterized by the presence of myofibroblastic hyperchromatic spindle cells, hylanized stroma formation, calcification, necrosis, and a multinodular growth pattern. Paul 2012-03-20T11:51:59Z mouse_pathology.ontology Solitary Myofibromatosis MPATH:824 myofibroma MPATH:824 A benign localized neoplasm arising from the subcutaneous tissues and skeletal muscle. It is characterized by the presence of myofibroblastic hyperchromatic spindle cells, hylanized stroma formation, calcification, necrosis, and a multinodular growth pattern. UMLS:C1266121 Generation of intracytoplasmic vacuoles otherwise unspecified. Paul 2012-03-22T08:19:10Z mouse_pathology.ontology MPATH:825 vacuolation MPATH:825 Generation of intracytoplasmic vacuoles otherwise unspecified. MPATH:curation granulomatous inflammation of the skin Paul 2012-03-22T08:22:17Z mouse_pathology.ontology MPATH:826 granulomatous dermatitis MPATH:826 granulomatous inflammation of the skin MPATH:curation chronic inflammation of the skin Paul 2012-03-22T08:24:43Z mouse_pathology.ontology MPATH:827 chronic dermatitis MPATH:827 chronic inflammation of the skin MPATH:curation locally demarcated region of inflammation in the skin Paul 2012-03-22T08:33:42Z mouse_pathology.ontology MPATH:828 focal dermatitis MPATH:828 locally demarcated region of inflammation in the skin MPATH:curation possession of both ovary and testis due to primary sex determination defect Paul 2012-03-22T08:42:35Z mouse_pathology.ontology MPATH:829 true hermaphrodite MPATH:829 possession of both ovary and testis due to primary sex determination defect MPATH:curation Any defect in the formation of septae not describable as perforation. mouse_pathology.ontology MPATH:83 septation defect MPATH:83 Any defect in the formation of septae not describable as perforation. Pathbase: Curation repair, reproduction, or replacement of lost or injured cells, tissues, or organs. Paul 2012-03-22T08:45:44Z mouse_pathology.ontology MPATH:830 regeneration MPATH:830 repair, reproduction, or replacement of lost or injured cells, tissues, or organs. MPATH:curation multilocular sites of muscle regeneration with centrally located nuclei. Paul 2012-03-22T08:48:14Z mouse_pathology.ontology MPATH:831 multifocal muscle regeneration MPATH:831 multilocular sites of muscle regeneration with centrally located nuclei. MPATH:curation persistent retraction of the prepuce behind the glans penis Paul 2012-03-22T08:52:08Z mouse_pathology.ontology MPATH:832 generally due to inflammation, but can cause further inflammation which exacerbates the condition paraphimosis MPATH:832 persistent retraction of the prepuce behind the glans penis MPATH:curation transition between acute and chronic inflammation. Paul 2012-03-22T08:55:14Z mouse_pathology.ontology MPATH:833 time varies form a few days to a week or so. Cells mainly lymphocytes and plasma cells, few macrophages or neutrophils. Less hemorrhage, edema and hyperemia. subacute inflammation MPATH:833 transition between acute and chronic inflammation. mpath:curation non-malignant neoplasia of the ovary. Paul 2012-03-22T09:04:54Z mouse_pathology.ontology tubular adenoma MPATH:834 ovarian tubulostromal tumor MPATH:834 non-malignant neoplasia of the ovary. ISBN:0-944398-45-6 MPATH:curation acute inflammation due to infection. Paul 2012-03-22T03:38:07Z mouse_pathology.ontology MPATH:835 acute septic inflammation MPATH:835 acute inflammation due to infection. MPATH:curation fibrosis in the skin Paul 2012-03-22T05:06:25Z mouse_pathology.ontology MPATH:836 dermal fibrosis MPATH:836 fibrosis in the skin MPATH:curation Fatty change in the mid-zonal region of the liver. Paul 2012-03-22T05:23:46Z mouse_pathology.ontology MPATH:837 hepatic mid-zonal fatty metamorphosis MPATH:837 Fatty change in the mid-zonal region of the liver. MPATH:curation carcinoma with an absence of epithelial structural differentiation. Paul 2012-03-22T05:26:31Z mouse_pathology.ontology MPATH:838 anaplastic carcinoma MPATH:838 carcinoma with an absence of epithelial structural differentiation. MPATH:curation anaplastic carcinoma of the liver. Paul 2012-03-22T05:28:22Z mouse_pathology.ontology MPATH:839 anaplastic hepatocellular carcinoma MPATH:839 anaplastic carcinoma of the liver. MPATH:curation Additional structure whether normally located or not. mouse_pathology.ontology MPATH:84 supernumerary structure MPATH:84 Additional structure whether normally located or not. Pathbase: Curation arthitis involving extensive macrophage infiltration into the joint. Paul 2012-03-22T05:37:23Z mouse_pathology.ontology MPATH:840 granulomatous arthritis MPATH:840 arthitis involving extensive macrophage infiltration into the joint. MPATH:curation Absence of eye. Paul 2012-03-22T05:40:44Z mouse_pathology.ontology MPATH:841 may be uni or bilateral anopthalmia MPATH:841 Absence of eye. MPATH:curation abnormally shaped vertebral body often triangular as opposed to rectangular. Paul 2012-03-22T05:55:21Z mouse_pathology.ontology MPATH:842 spontaneous or induced developmental lesion coccygeal hemivertebrae MPATH:842 abnormally shaped vertebral body often triangular as opposed to rectangular. PMID:1666161 Cessation of movement of a body fluid or liquid. Paul 2012-03-22T06:05:28Z mouse_pathology.ontology MPATH:843 stasis MPATH:843 Cessation of movement of a body fluid or liquid. MPATH:curation Cessation of the flow of bile due to bile duct blockage or overproduction. Paul 2012-03-22T06:06:41Z mouse_pathology.ontology MPATH:844 biliary stasis MPATH:844 Cessation of the flow of bile due to bile duct blockage or overproduction. MPATH:curation Evidence of residual placenta in utero without embryo. Paul 2012-03-24T03:03:26Z mouse_pathology.ontology MPATH:845 partial abortion MPATH:845 Evidence of residual placenta in utero without embryo. MPATH:curation acute inflammation of the footpad caused by foreign body. Paul 2012-03-24T03:05:46Z mouse_pathology.ontology MPATH:846 foreign body acute pododermatitis MPATH:846 acute inflammation of the footpad caused by foreign body. MPATH:curation Collection of epithelioid macrophages into a nodule Paul 2012-03-24T03:19:38Z mouse_pathology.ontology MPATH:847 granuloma MPATH:847 Collection of epithelioid macrophages into a nodule MPATH:curation Replacement of normal tissue by granuloma. Paul 2012-03-24T03:22:52Z mouse_pathology.ontology MPATH:848 effacing granuloma MPATH:848 Replacement of normal tissue by granuloma. MPATH:curation poorly differentiated adenocarcinoma of the mammary gland Paul 2012-03-24T03:26:01Z mouse_pathology.ontology MPATH:849 anaplastic mammary adenocarcinoma MPATH:849 poorly differentiated adenocarcinoma of the mammary gland MPATH:curation Alteration in the differentiation of a cell or tissue already showing a different, recognisable, differentiated state. mouse_pathology.ontology MPATH:85 This term is generally used in the context of embryonic cells or stem cells. transdifferentiation MPATH:85 Alteration in the differentiation of a cell or tissue already showing a different, recognisable, differentiated state. Pathbase: Pathology Committee Morphological abnormality following trauma or related insult such as infection. Paul 2012-03-24T03:28:03Z mouse_pathology.ontology MPATH:850 post-traumatic structural abnormality MPATH:850 Morphological abnormality following trauma or related insult such as infection. MPATH:curation acquired dysmorphology of the external pinna following trauma or infection. Paul 2012-03-24T03:29:48Z mouse_pathology.ontology MPATH:851 auricular deformation MPATH:851 acquired dysmorphology of the external pinna following trauma or infection. MPATH:curation A condition in which there is an unusually large proportion of plasma cells in tissues, exudates, or blood. Paul 2012-03-24T03:32:23Z mouse_pathology.ontology MPATH:852 plasmacytosis MPATH:852 A condition in which there is an unusually large proportion of plasma cells in tissues, exudates, or blood. MPAHTH:curation Abnormality of circulating plasma cells Paul 2012-03-24T03:33:57Z mouse_pathology.ontology MPATH:853 systemic plasmacytosis MPATH:853 Abnormality of circulating plasma cells MPATH:curation Plasmacytosis in the skin. Paul 2012-03-24T03:35:42Z mouse_pathology.ontology MPATH:854 cutaneous plasmacytosis MPATH:854 Plasmacytosis in the skin. MPATH:curation In vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances. Paul 2012-03-24T03:38:37Z mouse_pathology.ontology MPATH:855 Splendore-Hoeppli phenomenon MPATH:855 In vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances. PMID:18976399 Rupture of alveolar walls result in large rounded open air spaces in the lung Paul 2012-03-24T03:43:52Z mouse_pathology.ontology MPATH:856 bullous emphysema MPATH:856 Rupture of alveolar walls result in large rounded open air spaces in the lung MPATH:curation mutilocular bullous emphysema Paul 2012-03-24T03:45:01Z mouse_pathology.ontology MPATH:857 multifocal bullous emphysema MPATH:857 mutilocular bullous emphysema MPATH:curation Benign proliferation of capillaries made up of closely packed aggregations of capillaries, usually of normal caliber, separated by scant connective stroma. Paul 2012-03-24T03:46:38Z mouse_pathology.ontology MPATH:858 Most common kind of hemangioma thought to be derived from primitive mesenchymal stem cells. capillary hemangioma MPATH:858 Benign proliferation of capillaries made up of closely packed aggregations of capillaries, usually of normal caliber, separated by scant connective stroma. MPATH:curation Chronic granulomatous bacterial infection that affects the skin, and sometimes the viscera. Usually caused by S. aureus. Paul 2012-03-24T03:52:35Z mouse_pathology.ontology MPATH:859 botryomycosis MPATH:859 Chronic granulomatous bacterial infection that affects the skin, and sometimes the viscera. Usually caused by S. aureus. ISBN:0-7216-2921-0 Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations. mouse_pathology.ontology MPATH:86 organ specific developmental defect MPATH:86 Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations. Pathbase: Curation inflammation of the gall bladder Paul 2012-03-24T04:11:00Z mouse_pathology.ontology MPATH:860 cholecystitis MPATH:860 inflammation of the gall bladder MPATH:curation cholecystitis associated with edema Paul 2012-03-24T04:11:43Z mouse_pathology.ontology MPATH:861 edematous cholecystitis MPATH:861 cholecystitis associated with edema MPATH:curation Accumulation or trapping of air Paul 2012-03-24T04:17:10Z mouse_pathology.ontology MPATH:862 flatus MPATH:862 Accumulation or trapping of air MPATH:curation circumscribed ulceration of the skin penetrating the basement membrane as part of inflammation process. Paul 2012-03-24T04:18:54Z mouse_pathology.ontology MPATH:863 focal ulcerative dermatitis MPATH:863 circumscribed ulceration of the skin penetrating the basement membrane as part of inflammation process. MPATH:curation Inflammation of the outer ear. Paul 2012-03-25T10:00:59Z mouse_pathology.ontology MPATH:864 otitis externa MPATH:864 Inflammation of the outer ear. MPATH:curation Papillomatous inflammation of the tongue caused by a foreign body. Paul 2012-03-25T10:49:17Z mouse_pathology.ontology MPATH:865 foreign body acute papillomatous glossitis MPATH:865 Papillomatous inflammation of the tongue caused by a foreign body. MPATH:curationf> Thickening of the glandular epithelium Paul 2012-03-25T10:59:20Z mouse_pathology.ontology MPATH:866 Often with crystalloid formation gastric adenomatous hyperplasia MPATH:866 Thickening of the glandular epithelium MPATH:curation Major hepatic vein surrounded by fibrous connective tissue. Paul 2012-03-25T11:02:20Z mouse_pathology.ontology MPATH:867 hepatic central vein perivascular fibrosis MPATH:867 Major hepatic vein surrounded by fibrous connective tissue. MPATH:curation Dilation of the uterus Paul 2012-03-25T11:58:56Z mouse_pathology.ontology hydrometra MPATH:868 Usually assciated iwth hydrpometra uterine ectasia MPATH:868 Dilation of the uterus MPATH:curation Condition in which a part of the intestine has invaginated into another section of intestine, Paul 2012-03-25T12:04:33Z mouse_pathology.ontology MPATH:869 intussception MPATH:869 Condition in which a part of the intestine has invaginated into another section of intestine, MPATH:curation Abnormal morphology, differentiation or location of primordial germ cells or their descendents. Not neoplastic. mouse_pathology.ontology MPATH:87 germ cell defect MPATH:87 Abnormal morphology, differentiation or location of primordial germ cells or their descendents. Not neoplastic. Pathbase: Curation severe type of the disorder generally apparent at birth.Junctional epidermolysis bullosa involves defects in hemidesmosomes. t Paul 2012-03-25T12:10:57Z mouse_pathology.ontology MPATH:870 junctional epidermolysis bullosa MPATH:870 severe type of the disorder generally apparent at birth.Junctional epidermolysis bullosa involves defects in hemidesmosomes. t MPATH:curation Structural defects of the bony and muscular components of the vertebrae. Paul 2012-03-25T12:15:53Z mouse_pathology.ontology MPATH:871 spinal structural defects MPATH:871 Structural defects of the bony and muscular components of the vertebrae. MPATH:curation Abnormality of the kyphotic curvature of the spine. Paul 2012-03-25T12:17:10Z mouse_pathology.ontology MPATH:872 kyphosis MPATH:872 Abnormality of the kyphotic curvature of the spine. MPATH:curation Reduced size of the eye globe. Paul 2012-03-25T12:21:30Z mouse_pathology.ontology MPATH:873 micropthalmia MPATH:873 Reduced size of the eye globe. MPATH:curation Plasmacytosis is a hyperplastic condition in which there is an unusually large proportion of mature plasma cells in tissues, exudates, or blood. Paul 2012-09-03T04:32:06Z mouse_pathology.ontology MPATH:874 plasmacytosis MPATH:874 Plasmacytosis is a hyperplastic condition in which there is an unusually large proportion of mature plasma cells in tissues, exudates, or blood. MPATH:Pathology Committee cutaneous manifestation of plasmacytosis Paul 2012-09-03T04:36:31Z mouse_pathology.ontology MPATH:875 cutaneous plasmacytosis MPATH:875 cutaneous manifestation of plasmacytosis MPATH:Pathology Committee systemic manifestation of plasmacytosis. Disseminated in the circulation. Paul 2012-09-03T04:37:32Z mouse_pathology.ontology MPATH:876 systemic plasmacytosis MPATH:876 systemic manifestation of plasmacytosis. Disseminated in the circulation. MPATH:Pathology Committee An inflammatory condition of the lung, especially affecting the alveoli, associated with fever, chest symptoms, and congestion. Paul 2012-09-03T05:30:23Z mouse_pathology.ontology MPATH:877 Typically caused by an infection but there are a number of other causes. Infectious agents include: bacteria, viruses, fungi, and parasites. pneumonia MPATH:877 An inflammatory condition of the lung, especially affecting the alveoli, associated with fever, chest symptoms, and congestion. http://en.wikipedia.org/wiki/Pneumonia Pneumonia caused by aspiration of a foreign body. Paul 2012-09-03T05:34:45Z mouse_pathology.ontology MPATH:878 foreign body aspiration pneumonia MPATH:878 Pneumonia caused by aspiration of a foreign body. MPATH:Pathology Committee Inflammation of the tooth gum Paul 2012-09-03T05:37:29Z mouse_pathology.ontology MPATH:879 gingivitis MPATH:879 Inflammation of the tooth gum MPATH:Pathology Committee nephroblastomatosis mouse_pathology.ontology MPATH:88 Obsolete - subsumed into MPATH:82 nephroblastomatosis true MPATH:88 nephroblastomatosis Pathbase: Curation inflammation of the tooth gum caused by a foreign body. Paul 2012-09-03T05:38:14Z mouse_pathology.ontology MPATH:880 Generally caused by hair or food debris foreign body gingivitis MPATH:880 inflammation of the tooth gum caused by a foreign body. MPATH:Pathology Committee Fibrotic reaction to presence of a foreign body. Paul 2012-09-03T05:44:35Z mouse_pathology.ontology MPATH:881 reactive fibrosis MPATH:881 Fibrotic reaction to presence of a foreign body. MPATH:Pathology Committee Inflammatory cell infiltrate around bile ducts within the liver. Paul 2012-09-04T11:07:32Z mouse_pathology.ontology MPATH:882 hepatic peri-ductal inflammation MPATH:882 Inflammatory cell infiltrate around bile ducts within the liver. MPATH:JPS An interstitial, granulomatous, fibrosing inflammation of the lung, especially of the bronchioles and alveoli. Paul 2012-09-04T11:18:21Z mouse_pathology.ontology MPATH:883 pneumonitis MPATH:883 An interstitial, granulomatous, fibrosing inflammation of the lung, especially of the bronchioles and alveoli. MPATH:JPS Pneumonitis involving subpleural histiocytosis. Paul 2012-09-04T11:19:22Z mouse_pathology.ontology MPATH:884 histiocytic pneumonitis MPATH:884 Pneumonitis involving subpleural histiocytosis. MPATH:JPS metastatic tumour of unspecified origin Paul 2012-09-04T11:28:57Z mouse_pathology.ontology MPATH:885 metastatic tumor MPATH:885 metastatic tumour of unspecified origin MPATH:Pathology Committee Metastatic tumour of unspecified origin in the lung. Paul 2012-09-04T11:30:02Z mouse_pathology.ontology MPATH:886 pulmonary metastasis MPATH:886 Metastatic tumour of unspecified origin in the lung. MPATH:Pathology Committee Metastatic tumor in the lymphatic vessels or lymph nodes of unspecified origin. Paul 2012-09-04T11:32:15Z mouse_pathology.ontology MPATH:887 lymphatic metastasis MPATH:887 Metastatic tumor in the lymphatic vessels or lymph nodes of unspecified origin. MPATH:Pathology Committee Hypertrophy of the nail bed resulting in abnormally long, curved and thickened nails. Paul 2012-09-04T12:10:49Z mouse_pathology.ontology MPATH:888 onychogryphosis MPATH:888 Hypertrophy of the nail bed resulting in abnormally long, curved and thickened nails. MPATH:JPS intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano. PMID:21978358 Paul 2020-05-19T02:38:14Z mouse_pathology.ontology MPATH:889 Hirano body MPATH:889 intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano. PMID:21978358 MPATH:PNS Abnormal development of the heart or vascular tissue resulting in morphological abnormality. mouse_pathology.ontology MPATH:89 cardiovascular developmental defect MPATH:89 Abnormal development of the heart or vascular tissue resulting in morphological abnormality. Pathbase: Curation Necrosis in which the necrotic tissue shows deeply eosinophilic staining similar to that of fibrin. mouse_pathology.ontology MPATH:9 Frequently occurs in the walls of blood vessels and in connective tissue in diseases such as disseminated Lupus erythrematosis and polyarteritis nodosa, scleroderma, dermatomyositis and rheumatic fever. fibrinoid necrosis MPATH:9 Necrosis in which the necrotic tissue shows deeply eosinophilic staining similar to that of fibrin. ISBN:0781727286 Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber. mouse_pathology.ontology MPATH:90 aneurysm MPATH:90 Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber. Pathbase: Pathology Committee Formation of vessels between arterioles and venules bypassing capillary circulation. mouse_pathology.ontology Anastomosis arteriolovenularis anastomosis arteriovenosa arteriolovenular anastomosis MPATH:91 arteriovenous anastomosis MPATH:91 Formation of vessels between arterioles and venules bypassing capillary circulation. Pathbase: Curation Anastomosis arteriolovenularis Pathbase: Curation anastomosis arteriovenosa Pathbase: Curation arteriolovenular anastomosis Pathbase: Curation Structural, organisational or growth related defects in cardiac development. mouse_pathology.ontology heart abnormalities MPATH:92 cardiac defect MPATH:92 Structural, organisational or growth related defects in cardiac development. Pathbase: Curation heart abnormalities Pathbase: Curation Abnormality in the wall between the atria or ventricles, or defects in the truncoconal septum, of the heart; usually incomplete closure. mouse_pathology.ontology MPATH:93 cardiac septation defect MPATH:93 Abnormality in the wall between the atria or ventricles, or defects in the truncoconal septum, of the heart; usually incomplete closure. Pathbase: Curation Malformation of the membranous folds of the heart that prevent reflux of fluid. mouse_pathology.ontology MPATH:94 valve defect MPATH:94 Malformation of the membranous folds of the heart that prevent reflux of fluid. Pathbase: Curation Thickening of the wall of one or both of the heart ventricles. mouse_pathology.ontology MPATH:95 hypertrophic ventricle MPATH:95 Thickening of the wall of one or both of the heart ventricles. Pathbase: Pathology Committee Reduction in cell number of one or both of the two lower chambers of the heart. mouse_pathology.ontology MPATH:96 hypoplastic ventricle MPATH:96 Reduction in cell number of one or both of the two lower chambers of the heart. Pathbase: Pathology Committee Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima. mouse_pathology.ontology MPATH:97 dissecting aneurysm MPATH:97 Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima. ISBN:0781727286 A stretching and widening of the lymphatic vessels. mouse_pathology.ontology Lymphectasia telangiectasia lymphatica MPATH:98 lymphangiectasis MPATH:98 A stretching and widening of the lymphatic vessels. Pathbase: Pathology Committee Lymphectasia Pathbase: Curation telangiectasia lymphatica Pathbase: Curation An enlarged and often tortuous vein. mouse_pathology.ontology MPATH:99 varices MPATH:99 An enlarged and often tortuous vein. Pathbase: Pathology Committee 2020-05-19 * MPATH:$sequence(3,0,999)$ OBO-Edit 2.3-beta5 mouse_pathology.ontology 1.2 ORCID: 0000-0002-5111-7263 The Pathbase mouse pathology ontology provides a description of experimental mouse pathology phenotypes and incorporates 889 concepts including anatomical pathological entities and pathological processes. These are organised in an almost entirely is_a hierarchy of pathological processes or anatomical entities. Questions, comments and suggestions for amendment should be sent to the Co-ordinator, Dr. Paul Schofield, Dept. of Physiology Development and Neuroscience, University of Cambridge (PNS12@cam.ac.uk).The ontology was developed by the Pathbase consortium (http://www.pathbase.net) funded under the European Commission's Fifth Framework programme, Contract number QLRI-CT-1999-00320.