Ocular Immune-Mediated Inflammatory Disease Ontology Alastair K Denniston Georgios V Gkoutos Luke T Slater Samantha C Pendleton Tasanee Braithwaite DOID HPO ORDO Olivia's Vision PATO SNOMED-CT The Royal College of Ophthalmologists Uveitis Dataset 2018 UBERON https://github.com/sap218/ocimido https://creativecommons.org/licenses/by/3.0/ version 1.2.0 a core relation that holds between a whole and its part has part BFO:0000050 a core relation that holds between a part and its whole part of BFO:0000066 a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant uni-directional occurs in uni-directional x is a subclass of y is a RO:0002220 x adjacent to y if and only if x and y share a boundary adjacent to Own created investigated by RO:0002606 c is a substance that treats d if c is a material entity is substance that treats uni-directional treatment of investigation for SCDO:0000662 relationship between a condition and a description of distinctive characteristics or essential features uni-directional is characterised by RCOphth classification RCOphth disease activity status RCOphth complication treat SNOMEDCT:262202000 readcode:X90iG Major therapeutic interventions descriptors RCOphth therapeutic intervention Olivia's Vision Diagnostic and monitoring of disease RCOphth investigations UBERON:0000467 Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function UBERON anatomical system cause condition Reflecting Taxonomic classification - aetiology syndrome RCOphth associations Olivia's Vision Accoding to SUN descriptors RCOphth course DOID:83 HP:0000518 SNOMEDCT:128306009 Clouding of the lens in the eye that affects vision - mostly related to aging RCOphth cataract HP:0100014 SNOMEDCT:133853005 Thin sheet of fibrous tissue that develops on the surface of the macula (a small spot near the center of the retina and the part of the eye needed for sharp, central vision, which lets us see objects that are straight ahead) and can cause problems with central vision RCOphth epiretinal membrane DOID:1686 HP:0000501 SNOMEDCT:23986001 An eye condition where your optic nerve is damaged by the pressure of the fluid inside your eye RCOphth glaucoma macular edema HP:0040049 SNOMEDCT:37231002 readcode:F42y9 Macular edema is the build-up of fluid in the macula, an area in the center of the retina (light-sensitive tissue at the back of the eye). The macula is the part of the retina responsible for sharp, straight-ahead vision RCOphth macular oedema Olivia's Vision inflamed swelling swollen HP:0012647 PATO:0002104 SNOMEDCT:257552002 readcode:X79px Active inflammation described RCOphth inflammation activity Olivia's Vision SNOMEDCT:181162001 UBERON:0000964 The transparent front part of the eye that covers the iris, pupil, and anterior chamber UBERON cornea eye sight snellen chart HP:0030532 SNOMEDCT:16830007 readcode:XS7xI VA - clarity of vision test dependent on optical and neural factors RCOphth visual acuity Olivia's Vision SNOMEDCT:1028331000000101 readcode:XaEJw Genes responsible for a specific trait RCOphth genotypic data RCOphth other investigation UBERON:0003500 A blood vessel that is part of a cornea RCOphth corneal blood vessel Significant drug-related adverse events affecting future treatment RCOphth therapeutic intervention adverse affect medication medicine meds SNOMEDCT:718891000000103 RCOphth medical therapy Olivia's Vision OP surgery SNOMEDCT:257556004 readcode:X79q6 Relevant surgical therapy for each eye RCOphth surgical therapy Olivia's Vision cimzia SNOMEDCT:430306004 certolizumab enbrel SNOMEDCT:387045004 etanercept Olivia's Vision SNOMEDCT:442435002 golimumab SNOMEDCT:128931003 Cancer of the body's blood-forming tissues, including the bone marrow and the lymphatic system leukaemia flare PATO:0000389 SNOMEDCT:4532008 Sudden onset and less than 3 months duration RCOphth acute Olivia's Vision relapse PATO:0000427 SNOMEDCT:125324007 Repeated episodes separated by period of inactivity without treatment of at least 3 months in duration RCOphth recurrent Olivia's Vision PATO:0001863 SNOMEDCT:84499006 Persistent with more than 3 months duration, with relapse in less than 3 months after discontinuing treatment RCOphth chronic SNOMEDCT:40733004 Liable to be transmitted through the environment in a rapid manner RCOphth infectious bacterial DOID:104 ORPHA:163582 SNOMEDCT:87628006 Biological cells that cause disease RCOphth bacteria Olivia's Vision fungal DOID:1564 SNOMEDCT:312146001 readcode:XaDcj Invasive fungal takes over if individual has a weakened immune system RCOphth fungus Olivia's Vision DOID:1398 ORPHA:163588 Disease caused by a parasite, can be can still be transmitted across organisms RCOphth parasite viral DOID:934 ORPHA:163585 SNOMEDCT:34014006 Infection caused by the presence of a virus in the body, can infect almost any type of body tissue RCOphth virus Olivia's Vision Not transmittable, rather can be caused by genetics RCOphth non infectious PATO:0002098 SNOMEDCT:14799000 A disposition inhering in a tumour by virtue of the bearer's disposition to spread and invade distant tissues metastatic SNOMEDCT:56019007 A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole RCOphth systemic disease RCOphth masquerade HP:0002664 ORPHA:98057 PATO:0002011 SNOMEDCT:108369006 A neoplasm is a type of abnormal and excessive growth, called neoplasia, of tissue RCOphth neoplastic SNOMEDCT:404663008 A syndrome (a set of signs and symptoms) that is the consequence of cancer in the body, but unlike a mass effect, is not due to the local presence of cancer cells paraneoplastic SNOMEDCT:248281009 readcode:X76As RCOphth undifferentiated ORPHA:71505 SNOMEDCT:312940006 readcode:XaE69 A paraneoplastic disease of the eye associated with the presence of extraocular malignancy and circulating autoantibodies against retinal proteins cancer associated retinopathy flare PATO:0002354 Physically occuring RCOphth active Olivia's Vision inactive quiet SNOMEDCT:900000000000546006 A state or period of inactivity RCOphth quiescent Olivia's Vision A29 SNOMEDCT:417622004 Strong correlation between birdshot retinochoroidopathy and HLA-A29 RCOphth HLA-A29 Olivia's Vision B27 SNOMEDCT:417429003 Strongly associated with ankylosing spondylitis (chronic condition in which the spine and other areas of the body become inflamed) RCOphth HLA-B27 Olivia's Vision B51 SNOMEDCT:18501000 Associated with several diseases, including Behcets disease RCOphth HLA-B51 Olivia's Vision SNOMEDCT:798161000000102 Associated with sclerosis/rheumatoid arthritis RCOphth HLA-DR4 SNOMEDCT:312941005 readcode:XaE6A A paraneoplastic condition that causes visual symptoms of night-blindness and photopsias melanoma associated retinopathy ORPHA:279904 SNOMEDCT:420788006 readcode:XaE68 An ocular malignancy that is a subset of primary central system lymphoma primary intraocular lymphoma ACE SNOMEDCT:40743001 Serum level of ACE is often elevated in sarcoidosis and can be used to monitor disease activity, higher serum ACE levels indicate more active disease RCOphth angiotensin converting enzyme Olivia's Vision DOID:768 HP:0009919 ICD10:C69.2 ORPHA:790 SNOMEDCT:370967009 readcode:X00eS A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives from the tissues of the retina retinoblastoma SNOMEDCT:444708006 RCOphth CT thorax chest x ray chest xray SNOMEDCT:399208008 readcode:XE2az RCOphth chest x-ray Olivia's Vision SNOMEDCT:884131000000103 Diagnosis of some infectious diseases, especially tuberculosis (TB) RCOphth interferon gamma release assay SNOMEDCT:424489006 readcode:XE1Ou Tuberculin skin test screening for tuberculosis (TB) RCOphth mantoux SNOMEDCT:29567006 readcode:X70oK RCOphth MRI brain SNOMEDCT:991951000000100 readcode:X77bl To diagnose and to determine the stage of syphilis RCOphth syphilis serology UBERON:0001797 A transparent gelatinous, semigelatinous substance, tissue filling the cavity behind the lens of the eye and in front of the retina UBERON vitreous humour DOID:6039 HP:0007716 ORPHA:39044 SNOMEDCT:399705007 A malignant melanoma originating within the eye. The tumor originates from the melanocytes in the uvea uveal melanoma RA DOID:7148 HP:0001370 ICD10:M06 SNOMEDCT:69896004 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint rheumatoid arthritis Olivia's Vision SNOMEDCT:76601001 Injection into the muscle RCOphth intramuscular DOID:0050678 ORPHA:90340 SNOMEDCT:699861000 A rare systemic inflammatory disease characterized by early onset granulomatous arthritis, uveitis and skin rash blau syndrome DOID:3049 ICD10:M30.1 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding churg-strauss DOID:10223 ICD10:M33.0 ORPHA:221 SNOMEDCT:396230008 A type of idiopathic inflammatory myopathy characterized by evocative skin lesions and symmetrical proximal muscle weakness dermatomyositis DOID:12132 ORPHA:900 SNOMEDCT:195353004 An autoimmune hypersensitivity disease that is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera granulomatosis with polyangiitis DOID:13378 ICD10:M30.3 ORPHA:2331 A febrile, systemic, self-limiting vasculitis affecting children and characterized by inflammation in the medium sized vessels associated with coronary arterial aneurysms that may be life threatening when untreated kawasaki SNOMEDCT:110473004 A procedure to remove the lens of your eye and, in most cases, replace it with an artificial lens RCOphth cataract surgery SNOMEDCT:421885009 In rare cases where treatment with eye drops or laser haven't been effective, surgery for glaucoma involves removing part of the eye-drainage tubes to allow fluid to drain more easily RCOphth glaucoma surgery SNOMEDCT:420985004 Vitreoretinal eye surgery treats retinal detachments and other conditions RCOphth vitreo retinal surgery DOID:9810 ICD10:M30.0 ORPHA:767 SNOMEDCT:155441006 A rare, clinically heterogeneous, rheumatologic disease characterized by necrotizing inflammatory lesions affecting small and medium sized blood vessels polyarteritis nodosa DOID:12731 ICD10:H30.2 ICD9:363.21 SNOMEDCT:45688009 readcode:XS1W4 Disease of the eye characterized by inflammation of the narrowed area between the iris and the choroid. RCOphth pars planitis ICD10:M33.2 SNOMEDCT:31384009 readcode:N004 Polymyositis involves inflammation of the muscles or associated tissues polymyositis DOID:11406 ICD10:H30.9 ICD9:363.00 SNOMEDCT:16553002 readcode:F4320 Inflammation of the choroid (thin pigmented vascular coat of the eye) RCOphth choroiditis DOID:8886 HP:0012424 ICD10:H30.9 ICD9:363 SNOMEDCT:46627006 readcode:XE2RR readcode:Xa9BQ Inflammation of the choroid (thin pigmented vascular coat of the eye) and retina of the eye (light sensitive tissue that lines the back of the eye) RCOphth chorioretinitis ICD10:H30.9 ICD9:363.0 readcode:Xa9BQ A manifestation of T gondii infection. Ocular toxoplasmosis occurs when cysts deposited in or near the retina become active, producing tachyzoites. Focal necrotizing retinitis is the characteristic lesion, but retinal scars from prior reactivation are typically present RCOphth retinochoroiditis DOID:3612 HP:0032118 ICD10:H30.9 ICD9:363.00 SNOMEDCT:399463004 readcode:F4321 A breakdown and loss of cells in the retina (light sensitive tissue that lines the back of the eye) RCOphth retinitis DOID:2508 ICD10:M31.4 ORPHA:3287 SNOMEDCT:359789008 A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body takayasu's arteritis RCOphth onset acute Occurring or done quickly and unexpectedly or without warning RCOphth sudden Olivia's Vision gradual Proceeding in a gradual, subtle way, but with very harmful effects RCOphth insidious Olivia's Vision TB tuberculosis DOID:399 ICD10:A18.5 ORPHA:3389 SNOMEDCT:113861009 Spread through inhaling tiny droplets from the coughs or sneezes of an infected person. It is a serious condition, but can be cured with proper treatment. TB mainly affects the lungs. However, it can affect any part of the body, including the glands, bones and nervous system RCOphth mycobacterium tuberculosis Olivia's Vision syphilis DOID:4166 ICD10:A51.4 SNOMEDCT:76272004 Syphilis - a sexually transmitted infection, the signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary) RCOphth treponema pallidum Olivia's Vision cat scratch DOID:11258 ICD10:A28.1 ORPHA:50839 SNOMEDCT:79974007 readcode:A783 Cat-scratch disease - from a scratch or bite of a cat.Symptoms typically include a non-painful bump or blister at the site of injury and painful and swollen lymph nodes - people may feel tired, have a headache, or a fever. Cat-scratch disease is caused by the bacterium Bbrtonella henselae which is believed to be spread by the cat’s saliva RCOphth bartonella henselae Olivia's Vision lyme DOID:11729 ICD10:A69.2 ORPHA:91546 SNOMEDCT:23502006 readcode:A8710 Lyme disease - known as Lyme borreliosis, caused/spread by ticks. The most common sign of infection is an expanding area of redness on the skin, known as erythema migrans, that appears at the site of the tick bite about a week after it occurred RCOphth borrelia burgdorferi Olivia's Vision SNOMEDCT:89188001 readcode:X00cT An acquired inflammatory uveitis that belongs to the heterogenous group of white dot syndromes RCOphth acute posterior multifocal placoid pigment epitheliopathy ORPHA:284454 SNOMEDCT:312929003 readcode:XaE5w An inflammatory retinopathy in the category of white dot syndromes typified by acute loss of one or more zones of outer retinal function acute zonal occult outer retinopathy fuchs DOID:9375 ICD10:H20.8 ORPHA:263479 SNOMEDCT:11226001 readcode:F4420 fuchs uveitis syndrome A syndrome that is a chronic unilateral iridocyclitis appearing with the triad of heterochromia, predisposition to cataracts and glaucoma, and keratitic percipitates on the posterior corneal surface RCOphth fuch's heterochromic iridocyclitis Olivia's Vision RCOphth cold sore SNOMEDCT:407451003 HSV1 Sores around the mouth and lips (fever blisters or cold sores) RCOphth herpes simplex virus 1 Olivia's Vision RCOphth DOID:8704 SNOMEDCT:407450002 HSV2 Genital herpes (sores around the genitals or rectum) RCOphth herpes simplex virus 2 RCOphth shingles ICD10:B02.3 SNOMEDCT:309465005 readcode:XaBsP VZV Causes chickenpox and shingles RCOphth varicella zoster virus Olivia's Vision RCOphth DOID:0080160 ICD10:B25 CMV Common virus that is usually harmless, sometimes causes problems in babies if caught during pregnancy (congenital CMV) RCOphth cytomegalovirus RCOphth SUN vitreous haze 0.5+ UBERON:0002443 A blood vessel that is part of a choroid UBERON choroidal blood vessel DOID:1508 ICD10:B37 SNOMEDCT:78048006 Genus of yeasts, by Candida sp. Fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain - systemic Candida infections are usually confined to severely immunocompromised persons RCOphth candidia DOID:13564 ICD10:B44 SNOMEDCT:65553006 Genus of mold - disease of humans and animals caused by members of the genus Aspergillus sp. Infecting lungs, brain, kidney, heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system RCOphth aspergillus RCOphth other fungi RCOphth other parasites DOID:9790 ICD10:B83.0 ORPHA:3343 SNOMEDCT:49078004 Rare infection caused by roundworm parasites RCOphth toxocara canis ICD10:B73 ORPHA:2737 river blindness onchocerciasis (river blindness) is caused by the roundworm onchocerca volvus RCOphth onchocerca A progressive parasitic disease affecting the outer retina and retinal pigment epithelium RCOphth diffuse unilateral subacute neuroretinitis RCOphth undifferentiated viral syndrome DOID:7147 ICD10:M45 SNOMEDCT:9631008 Chronic condition in which the spine and other areas of the body become inflamed - type of arthritis RCOphth ankylosing spondylitis sarcoid DOID:11335 ICD10:D86 ORPHA:797 SNOMEDCT:31541009 A disease involving abnormal collections of inflammatory cells that form lumps known as granulomas. The disease usually begins in the lungs, skin, or lymph nodes RCOphth sarcoidosis Olivia's Vision MS DOID:2377 ICD10:G35 SNOMEDCT:24700007 A condition that can affect the brain and spinal cord, causing a wide range of potential symptoms, including problems with vision, arm or leg movement, sensation or balance RCOphth multiple sclerosis Olivia's Vision DOID:13241 ICD10:M35.2 ORPHA:117 SNOMEDCT:310701003 readcode:AD61 A rare disorder that causes blood vessel inflammation throughout your body RCOphth behcet disease DOID:12029 ICD10:H44.1 ORPHA:79098 SNOMEDCT:75315001 readcode:F4010 A diffuse granulomatous inflammation of the uveal layer of both eyes following trauma to one eye RCOphth sympathetic ophthalmia VKH DOID:12297 ICD10:H20.8 ORPHA:3437 SNOMEDCT:193497004 readcode:F4423 A rare disease that affects several parts of the body, including the eyes, ears, nervous system, and skin - caused by chronic inflammation of melanocytes (specialised cells that produce a pigment called melanin) RCOphth vogt koyanagi harada disease Olivia's Vision ORPHA:91500 A rare form of bilateral non-granulomatous anterior uveitis found in a sub-population of patients with tubulointerstitial nephritis (inflammation of the area of the kidney known as the interstitium, which consists of a collection of cells, extracellular matrix, and fluid surrounding the renal tubules) RCOphth tubulointerstitial nephritis and uveitis JIA JRA juvenile arthritis HP:0005681 ICD10:M08.0 ORPHA:92 SNOMEDCT:410502007 JIA is inflammation of one or more of your joints, occuring in patients younger than 16 years of age RCOphth juvenile idiopathic arthritis OIivia's Vision Characterized by multifocal plaque-like lesions scattered over the posterior pole RCOphth ampiginous choroiditis LogMAR for each eye (as measured by ETDRS charts) RCOphth LogMAR increased worse HP:0012649 SNOMEDCT:230993007 readcode:Xa49W Evidence of increase ocular inflammation RCOphth worsening Olivia's Vision stable SNOMEDCT:58158008 No apparent change in level RCOphth no change Olivia's Vision better decreased HP:0012648 SNOMEDCT:385633008 readcode:Xa49J Evidence of reduced ocular inflammation but still active RCOphth improving Olivia's Vision Disease inactive for less than 3 months RCOphth inactivity of recent onset remission SNOMEDCT:765210000 Disease inactive for more than 3 months, but on treatment RCOphth in remission on treatment Olivia's Vision remission SNOMEDCT:765205004 Disease inactive for more than 3 months, and off treatment RCOphth in remission off treatment Olivia's Vision ORPHA:35686 SNOMEDCT:312491004 readcode:XaDw9 A rare inflammatory eye condition, those affected have lesions in the eye that last from weeks to months and involve scarring of the eye tissue RCOphth serpiginous choroiditis HP:0025560 SNOMEDCT:246993000 readcode:X75j1 AC cells Inflammation in the AC causes breakdown of the blood–aqueous barrier and results in an increase in the number of cells RCOphth anterior chamber cell RCOphth HP:0031616 SNOMEDCT:246992005 readcode:X75j0 AC flare Protein that has released through inflammed vasculature inside the eye RCOphth anterior chamber flare RCOphth HP:0030652 Obscuration of fundus details by vitreous cells and protein exudation. It impacts vision more profoundly than anterior inflammation and therefore used commonly as an outcome measure for clinical trials involving intermediate, posterior, or panuveitis RCOphth vitreous haze RCOphth other non infectious non systemic disease high pressure DOID:9282 HP:0007906 ICD10:H40.0 SNOMEDCT:4210003 readcode:XE2a7 OHT is generally defined as consistently elevated intraocular pressure (IOP) - greater than 21mmHg RCOphth ocular hypertension Olivia's Vision Steroid induced OHT RCOphth corticosteroid induced ocular hypertension RCOphth other non infectious systemtic disease DOID:0060058 HP:0002665 ORPHA:223735 SNOMEDCT:399600009 lymphoma HP:0025563 SUN AC cells 0 HP:0025562 SUN AC cells 0.5+ HP:0025561 SUN AC cells 1+ RCOphth other drug reaction requiring cessation or future avoidance HP:0030533 RCOphth unaided HP:0030534 SNOMEDCT:419775003 Clarity of vision RCOphth best corrected HP:0030535 SNOMEDCT:419475002 A pinhole occluder is an opaque disk with one or more small holes through it to test visual acuity, temporarily removing the effects of refractive errors such as myopia RCOphth pin hole SNOMEDCT:7510005 Color blindness or deficiency, means your photopigments are abnormal causing your color perception to be limited RCOphth colour vision HP:0200057 ICD10:H57.0 SNOMEDCT:232122003 readcode:X00ft RAPD RCOphth relative afferent pupillary defect RCOphth HP:0030586 Number of Ishihara Plates (x/y) - test for colour blindness RCOphth ishihara plate HP:0025564 SUN AC cells 2+ flare symptom SNOMEDCT:308923001 Disease activity and other clinical features for each eye RCOphth clinical symptom Olivia's Vision light sensitive overexposure HP:0000613 ICD10:H53.1 PATO:0000547 SNOMEDCT:409668002 SYMP:0000210 Discomfort or pain to the eyes due to light exposure or by presence of actual physical sensitivity of the eyes RCOphth photophobia Olivia's Vision blurry HP:0000622 PATO:0001518 The loss of sharpness of vision and the inability to see fine details RCOphth blurred vision Olivia's Vision floater HP:0100832 ICD10:H43.3 SNOMEDCT:162278001 readcode:1B74 Floaters are small shapes that some people see floating in their field of vision RCOphth vitreous floater Olivia's Vision HP:0030786 ICD10:H53.1 SNOMEDCT:56170001 readcode:F481C Photopsia is the presence of perceived flashes of light RCOphth photopsia ICD10:H53.4 SNOMEDCT:193670002 An area in your range of vision that you cannot see properly but which you really should be able to see RCOphth blind spot ICD10:H53.9 SNOMEDCT:42134006 Distorted vision is when familiar objects look wavy or bent incorrectly RCOphth distortion HP:0025565 SUN AC cells 3+ HP:0025566 SUN AC cells 4+ SNOMEDCT:302151004 UBERON:0010230 readcode:Xa8EA The core globe-shaped component of the camera-type eye UBERON eyeball of camera-type eye the front of SNOMEDCT:32259006 UBERON:0001801 readcode:Xa8EB Parts of the eye that lie in front of the lens UBERON anterior segment of eyeball Olivia's Vision SNOMEDCT:303295006 UBERON:0019207 readcode:Xa9Ri Part of the eye that consists of both the retina and the optic choroid UBERON chorioretinal region the back of SNOMEDCT:77205005 UBERON:000180 readcode:Xa8EC Parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) UBERON posterior segment of eyeball Olivia's Vision SNOMEDCT:181160009 UBERON:0001766 Anterior chamber of the anterior segment of the eye UBERON anterior chamber SNOMEDCT:280587006 UBERON:0001796 readcode:Xa1TS A thick watery refractive medium that fills the space between the lens and the cornea - secreted from the ciliary epithelium that supports the lens UBERON aqueous humour of eyeball SNOMEDCT:65643003 UBERON:0001767 readcode:Xa1TQ Posterior chamber of the anterior segment of the eye UBERON posterior chamber SNOMEDCT:181172003 UBERON:0001776 Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina UBERON choroid SNOMEDCT:181171005 UBERON:0000966 The innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates UBERON retina SNOMEDCT:312742006 UBERON:0001799 readcode:XaE1P The chamber in the eyeball enclosing the vitreous humor, bounded anteriorly by the lens and ciliary body and posteriorly by the posterior wall of the eyeball UBERON vitreous chamber of eyeball SNOMEDCT:47538007 UBERON:0001798 Gelatinous mucoid tissue UBERON vitreous body SUN flare 0 HP:0031618 SUN flare 1+ HP:0031619 SUN flare 2+ HP:0031620 SUN flare 3+ HP:0031621 SUN flare 4+ SNOMEDCT:51082008 UBERON:0034936 Flattened posterior region of ciliary body UBERON pars plana of cillary body choroidal lymphoma SNOMEDCT:9668006 UBERON:0001605 readcode:Xa1YR A ring of smooth muscle in the middle layer of the eye UBERON cillary muscle iris lymphoma SNOMEDCT:261034003 readcode:X9088 RCOphth unifocal RCOphth paucifocal SNOMEDCT:524008 readcode:X78tO RCOphth multifocal SNOMEDCT:19648000 readcode:X790D RCOphth diffuse by mouth capsule pill tablet SNOMEDCT:828491000000105 RCOphth oral Olivia's Vision SNOMEDCT:386975001 tacrolimus SNOMEDCT:35146001 UBERON:0001771 readcode:Xa1Yy The central circular aperture of the iris through which light rays enter the eye UBERON pupil cyclosporin neoral SNOMEDCT:80906007 ciclosporin Olivia's Vision SNOMEDCT:387420009 cyclophosphamide MTX MXT amethopterin SNOMEDCT:387381009 methotrexate Olivia's Vision SNOMEDCT:372574004 azathioprine pred forte predforte prednisol predsol SNOMEDCT:116601002 prednisolone Olivia's Vision cellcept myfenax SNOMEDCT:109131004 Mycophenolate mofetil mycophenolate Olivia's Vision IV drip infusion vein SNOMEDCT:43060002 Injection into the vein RCOphth intravenous Olivia's Vision medrol SNOMEDCT:116593003 methylprednisolone Olivia's Vision rituxan SNOMEDCT:386919002 rituximab Olivia's Vision SNOMEDCT:81016008 UBERON:0001783 readcode:Xa1Uo The optic disc or optic nerve head is the location where ganglion cell axons exit the eye to form the optic nerve UBERON optic disc humira SNOMEDCT:407317001 adalimumab Olivia's Vision drop SNOMEDCT:385124005 RCOphth topical to ocular surface Olivia's Vision corticoid steroid Anti-inflammatory medicines used to treat a range of conditions corticosteroid Olivia's Vision maxitrol dexamethasone neomycin and polymyxin B ophthalmic Olivia's Vision presenting SNOMEDCT:2925007 fluorometholone betamethasone SNOMEDCT:116571008 betnesol Olivia's Vision lotemax SNOMEDCT:419711001 loteprednol Olivia's Vision mydriacyl SNOMEDCT:387526001 tropicamide Olivia's Vision neurofen SNOMEDCT:372870003 Beta-adrenergic blocking agents drugs that reduces blood pressure beta-blocker cosopt timoptol SNOMEDCT:372880004 timolol Olivia's Vision SNOMEDCT:765073001 Reduces the intraocular pressure (IOP) by a mechanism of action different from other drugs - namely by increasing the uveoscleral outflow prostaglandin analogue xalatan latanoprost Olivia's Vision lumigan SNOMEDCT:129492005 bimatoprost Olivia's Vision SNOMEDCT:372816000 Suppress activity of carbonic anhydrase carbonic anhydrase inhibitor trusopt SNOMEDCT:373447009 dorzolamide Olivia's Vision azopt SNOMEDCT:386925003 brinzolamide Olivia's Vision SNOMEDCT:86308005 Stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system sympathomimetic iopidine SNOMEDCT:391786008 readcode:x05LJ apraclonidine Olivia's Vision alphagan SNOMEDCT:108827001 brimonidine Olivia's Vision HP:0012776 A structural anomaly of the ciliary body HPO abnormal cillary body morphology HP:0012055 HPO cillary body melanoma DOID:13141 HP:0000554 ICD9:364.3 ORPHA:98715 SNOMEDCT:128473001 readcode:F443 Main types of uveitis RCOphth uveitis iritis DOID:1407 HP:0012122 ICD10:H20.0 ICD9:364.0 ORPHA:280886 SNOMEDCT:410692006 readcode:X00be Inflammation of the uveal tract in the anterior chamber RCOphth anterior uveitis Olivia's Vision IU DOID:12732 HP:0012124 ORPHA:279914 SNOMEDCT:314429009 readcode:XaF44 Inflammation localised to the vitreous RCOphth intermediate uveitis Olivia's Vision DOID:12574 HP:0012123 ORPHA:280892 SNOMEDCT:43363007 readcode:F4322 Inflammation of the choroid, may affect the retina and/or the optic nerve, and may lead to permanent loss of vision RCOphth posterior uveitis pan uveitis DOID:12030 HP:0012121 ICD9:360.11 ORPHA:280898 SNOMEDCT:75614007 readcode:F4011 Inflammation of all layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. These make up the middle layer of the eye. The condition can also affect the lens, retina, optic nerve, and vitreous, causing reduced vision or blindness RCOphth panuveitis Olivia's Vision RCOphth non systemic disease SNOMEDCT:312951006 readcode:XaE6N An inflammatory retinal disorder, typically observed in young patients, that is characterized by unilateral visual loss and the presence of small, punctate, yellow-white lesions that involve the outer retina RCOphth multiple evanescent white dot syndrome SNOMEDCT:312950007 readcode:XaE6M An inflammatory disease affecting the choroid and retina which can lead to vision loss RCOphth punctate inner choroidopathy birdshot DOID:0111079 ORPHA:179 SNOMEDCT:231981005 readcode:X00cU birdshot chorioretinopathy BCR is a rare form of chronic, bilateral, posterior uveitis with a distinctive clinical phenotype, and a strong association with HLA-A29. It predominantly affects people in middle age RCOphth birdshot retinochoroidopathy Olivia's Vision RCOphth HP:0007774 HPO hypoplasia of the cillary body SNOMEDCT:310575006 UBERON:0001768 The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid UBERON uvea SNOMEDCT:732081000 UBERON:0011892 Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris UBERON anterior uvea UBERON:0001775 The thickened portion of the vascular tunic, composed of ciliary muscle and ciliary processes UBERON cillary body RCOphth iris signs DOID:9383 HP:0001094 ICD10:H20 SNOMEDCT:77971008 readcode:X00be A type of anterior uveitis occuring in the iris and of the ciliary body DOID HPO iridocyclitis UBERON:0000019 An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid UBERON camera-type eye ciliary body lymphoma SNOMEDCT:10737006 UBERON:0005908 readcode:Xa1Ut A serous sac which is the aggregate of the conjunctiva plus the conjunctival space UBERON conjunctival sac SNOMEDCT:181161008 UBERON:0001811 The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball UBERON conjunctiva UBERON:0000047 An eye with one concave chamber UBERON simple eye SNOMEDCT:281831001 UBERON:0002104 readcode:Xa1tb The sensory system subserving the sense of vision UBERON visual system shunt implant SNOMEDCT:303276004 readcode:Xa9R5 Device that reduces the intraocular pressure (IOP) in glaucoma by draining the fluid (aqueous humour) from inside the eye aqueous shunt Olivia's Vision A surgical operation which lowers the intraocular pressure (IOP) inside the eye in patients with glaucoma - by making a small hole in the eye wall (sclera) trabeculectomy SNOMEDCT:36812006 Surgical removal of part of the iris iridectomy SNOMEDCT:172530003 readcode:72652 Laser surgery to the introcular lens, might be needed after cataract surgery posterior capsulotomy SNOMEDCT:423552003 A treatment used to treat angle-closure glaucoma peripheral iridotomy cloudy lens opacity HP:0007759 SNOMEDCT:81858005 SYMP:0000234 readcode:XC06w Where objects are obscured and appear milky - often mistaken for blurry vision Olivia's Vision cloudy vision Olivia's Vision DOID:3234 ORPHA:46135 central nervous system lymphoma herpes DOID:8566 ICD10:B00.5 SNOMEDCT:88594005 A viral infectious disease that results in the formation of lesions herpes simplex virus Olivia's Vision DOID:9074 HP:0002725 ICD10:M32 ORPHA:536 SNOMEDCT:55464009 SLE A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes systemic lupus erythematosus lens SNOMEDCT:306719005 UBERON:0000965 readcode:XaAqU Transparent part of camera-type eye that helps to refract light to be focused on the retina UBERON lens of camera-type eye Olivia's Vision toxoplasmosis DOID:9965 ICD10:B58 SNOMEDCT:187192000 Mild, flu-like illness such as muscle aches and tender lymph nodes. In a small number of people, eye problems may develop RCOphth toxoplasma gondii Olivia's Vision treponema pallidum haemagglutination assay high IOP increased pressure PATO:0001576 SNOMEDCT:51590001 PATO high intraocular pressure Olivia's Vision low IOP HP:0032547 PATO:0001575 SNOMEDCT:29165009 PATO low intraocular pressure SNOMEDCT:231750006 readcode:X00XO Microsurgery procedure that removes part or all of the crystalline lens from the eye (via pars plana) Olivia's Vision lensectomy SNOMEDCT:1015591000000105 readcode:X77bm fluorescent treponemal anitbody absorption test treponemal test non treponemal test SNOMEDCT:19869000 rapid plasma reagin DOID:10176 ICD9:363.05 SNOMEDCT:410471004 An inflammatory optic neuropathy characterized by optic disc edema and lipid within the fovea in a macular star pattern - often associated with cells in the vitreous RCOphth neuroretinitis SNOMEDCT:7786006 venereal disease reference laboratory immunoassay responsive PATO:0000487 SNOMEDCT:80074009 PATO responsive to Olivia's Vision PATO:0001192 PATO hyperresponsive PATO:0001194 PATO hyporesponsive HP:0025337 SNOMEDCT:703630003 readcode:X75cR A reddish appearance over the white part (sclera) of the eye red eye surface of SNOMEDCT:361318005 UBERON:0012430 Outer layer of eyeball UBERON tunica fibrosa of eyeball Olivia's Vision SNOMEDCT:181163006 UBERON:0001773 The white outer layer of the eyeball UBERON sclera RCOphth cornea signs DOID:1909 HP:0002861 ICD10:C69.9 SNOMEDCT:274087000 readcode:XM0ps malignant melanoma HP:0004328 An abnormality of the anterior segment of the eyeball HPO abnormal anterior eye segment morphology DOID:8869 ICD10:G36.0 ORPHA:71211 SNOMEDCT:25044007 readcode:F210 NMOSD devic optic neuromyelitis Inflammatory demyelinating diseases of the central nervous system characterized mainly by attacks of uni or bilateral optic neuritis and acute myelitis neuromyelitis optica spectrum disorder HP:0000593 Abnormality of the anterior chamber HPO abnormal anterior chamber morphology aqueous tap HP:0011531 SNOMEDCT:95802009 Inflammation of the vitreous body HPO vitritis ICD10:H20.0 SNOMEDCT:17657000 readcode:XE18l Disorder of iris and ciliary body SNOMED-CT cyclitis SNOMEDCT:231754002 readcode:X00XU vitreous tap SNOMEDCT:258066000 readcode:X7A0j polymerase chain reaction HP:0011524 ICD10:C69.4 SNOMEDCT:255012009 readcode:X78bc iris melanoma age PATO:0000261 SNOMEDCT:272130008 SNOMEDCT:410598002 readcode:XM0EB person categorised by age PATO maturity Olivia's Vision teenager PATO:0001189 SNOMEDCT:133937008 readcode:ZV212 Between the onset of puberty and maturity PATO adolescent Olivia's Vision PATO:0001501 Individual lacking complete growth, differentiation, or development PATO immature child PATO:0001190 SNOMEDCT:410601007 Not fully grown or developed PATO juvenile Olivia's Vision adult PATO:0001701 SNOMEDCT:133936004 readcode:X78yc Exhibiting complete growth, differentiation, or development PATO mature Olivia's Vision baby PATO:0002206 SNOMEDCT:133933007 readcode:Ua0Wk At the point or short after birth PATO neonatal Olivia's Vision pre teen PATO:0001186 SNOMEDCT:410600008 Being at the age immediately before puberty PATO prepubescent Olivia's Vision puberty PATO:0000455 Having arrived at the onset of puberty (the age at which sex glands become functional) but not yet fully mature PATO pubescent pain sore HP:0200026 ICD10:H57.1 SNOMEDCT:41652007 SYMP:0000828 An unpleasant sensation characterized by physical discomfort localized to the eye RCOphth eye pain Olivia's Vision HLA SNOMEDCT:47038001 readcode:X80h5 SNOMED-CT human leucocyte antigen Olivia's Vision DOID:0050204 HP:0031693 SNOMEDCT:240530001 EBV epstein-barr virus SNOMEDCT:75732000 readcode:X00XW Surgery to remove some or all of the vitreous humor from the eye Olivia's Vision vitrectomy SNOMEDCT:1006121000000108 readcode:XaYKC lyme serology SNOMEDCT:52366000 bartonella serology SNOMEDCT:1009771000000103 readcode:XaJGe toxoplasma serology SNOMEDCT:997061000000107 serology toxocara serology remicade SNOMEDCT:386891004 Olivia's Vision infliximab Olivia's Vision actemra SNOMEDCT:724164001 Olivia's Vision tocilizumab Olivia's Vision eyeball SNOMEDCT:81745001 UBERON:0000970 Organ that detects light UBERON eye Olivia's Vision SNOMEDCT:18944008 UBERON:0004549 readcode:Xa9Rl An eye that is part of a right side of organism Olivia's Vision right eye SNOMEDCT:8966001 UBERON:0004548 readcode:Xa9Rm An eye that is part of a left side of organism Olivia's Vision left eye synechiae HP:0007833 SNOMEDCT:5242004 An eye condition where the iris adheres to either the cornea or lens Olivia's Vision anterior chamber synechiae Olivia's Vision anterior synechiae HP:0011483 ICD10:H21.5 SNOMEDCT:70992005 readcode:F4472 Adhesions between the iris and the cornea HPO anterior synechiae of the anterior chamber Olivia's Vision posterior synechiae HP:0011484 ICD10:H21.5 SNOMEDCT:111512005 readcode:F4471 Adhesions between the iris and the lens HPO posterior synechiae of the anterior chamber Olivia's Vision HP:0031615 SNOMEDCT:87807004 SYMP:0000301 readcode:F4406 Presence of pus producing a fluid level in the inferior part of the anterior chamber RCOphth hypopyon baerveldt SNOMEDCT:410447006 Olivia's Vision baerveldt tube shunt Olivia's Vision SNOMEDCT:410446002 ahmed tube shunt SNOMEDCT:360120008 molteno tube anti-aquaporin-4 anitbody PATO:0000965 SNOMEDCT:272134004 readcode:XM0EG PATO symmetry symetric PATO:0000632 SNOMEDCT:255473004 readcode:X790U Olivia's Vision symmetrical Olivia's Vision PATO:0000616 SNOMEDCT:4128009 readcode:X7909 Olivia's Vision asymmetrical both eye PATO:0001324 Olivia's Vision bilateral Olivia's Vision DOID:8893 ICD10:L40 SNOMEDCT:9014002 A skin condition that causes red, flaky, crusty patches of skin covered with silvery scales Olivia's Vision psoriasis ORPHA:280921 SNOMEDCT:766933000 A rare inflammatory eye disease, of unknown etiology, characterized by generalized inflammation of the uvea (iris, ciliary body, choroid), retina and vitreous with consequent ciliary spasm and posterior synechiae formation, leading to acute or chronic, unilateral or bilateral visual impairment and ocular discomfort or pain. Patients present an increased risk of development of cataracts, secondary glaucoma, cystoid macular edema and/or retinal detachment. It could potentially result in vision loss Olivia's Vision idiopathic panuveitis vexol SNOMEDCT:330545009 Olivia's Vision rimexolone Olivia's Vision diamox SNOMEDCT:33664007 Olivia's Vision acetazolamide Olivia's Vision avastin SNOMEDCT:409406007 Olivia's Vision bevacizumab Olivia's Vision kenalog SNOMEDCT:6028009 Olivia's Vision triamcinolone Olivia's Vision durezol SNOMEDCT:438200007 Olivia's Vision difluprednate Olivia's Vision maxidex ozurdex SNOMEDCT:7561000 Olivia's Vision dexamethasone Olivia's Vision impact NOD2 gene mutation no abnormality of vision visual field field of vision Olivia's Vision HP:0032036 SNOMEDCT:251686008 readcode:X77Mg Contrast sensitivity refers to a measure of how much contrast a person requires to see a target HPO contrast sensitivity SNOMEDCT:18234004 Transmitting impulses to the brain from the retina at the back of the eye UBERON optic nerve clinical feature ocular clinical sign vision related symptom ocular symptom RCOphth conjunctival and sclera signs RCOphth conjunctival injection SNOMEDCT:255505007 readcode:X7916 RCOphth sectoral RCOphth circumlimbal HP:0100534 ICD10:H15.1 ICD9:379.0 SNOMEDCT:815008 readcode:X00aA Inflammation of the episclera, a thin layer of tissue covering the sclera RCOphth episcleritis DOID:728 ICD9:379.02 SNOMEDCT:70558001 readcode:F4K02 RCOphth nodular episcleritis RCOphth non-nodular episcleritis DOID:13794 ICD9:379.03 SNOMEDCT:63454000 readcode:F4K03 Anterior scleritis is defined as scleral inflammation anterior to the extraocular recti muscles RCOphth anterior scleritis RCOphth non-necrotising RCOphth necrotising HP:0025341 ICD10:H18.0 SNOMEDCT:246998009 readcode:X75j6 An inflammatory cellular deposit seen on corneal endothelium RCOphth keratic precipitate RCOphth non-granulomatous A collection of immune cells known as macrophages. Granulomas form when the immune system attempts to wall off substances it perceives as foreign but is unable to eliminate RCOphth granulomatous RCOphth stellate DOID:11164 HP:0000585 An abnormality of the cornea characterized by the deposition of calcium in a band across the central cornea RCOphth band keratopathy RCOphth involving visual axis corneal edema DOID:11030 SNOMEDCT:27194006 The swelling of the cornea following ocular surgery, trauma, infection, inflammation as well as a secondary result of various ocular diseases RCOphth corneal oedema HP:0011486 SNOMEDCT:251691009 readcode:X77Mo An abnormal anteroposterior thickness of the cornea RCOphth corneal thickness ICD10:H21.8 SNOMEDCT:248510004 readcode:X76Fq RCOphth nodules HP:0012805 SNOMEDCT:400964006 Transmission of light through the iris as visualized upon slit lamp examination or infrared iris transillumination videography. The light passes through defects in the pigmentation of the iris RCOphth transillumination of iris RCOphth surgical iris defect RCOphth traumatic iris defect HP:0011497 SNOMEDCT:312909004 readcode:XaE5Z New growth of vessels on the surface of the iris RCOphth iris neovascularisation RCOphth iridocorneal angle narrow RCOphth choroidal signs RCOphth retinal signs RD DOID:5327 HP:0000541 SNOMEDCT:42059000 Separation of the inner layers of the retina (neural retina) from the pigment epithelium RCOphth retinal detachment Olivia's Vision RCOphth other retinal pathology RCOphth retinovascular pathology ICD10:H35.6 SNOMEDCT:28998008 A disorder of the eye in which bleeding occurs in the retina, the light sensitive tissue, located on the back wall of the eye RCOphth retinal haemorrhage HP:0031606 ICD10:H34.2 SNOMEDCT:39832008 Fluffy white patch on the retina, representing localized areas of dense white swelling of the retinal nerve fibre layer RCOphth cotton wool spot SNOMEDCT:95688008 A white centered retinal hemorrhage and are associated with multiple systemic illnesses RCOphth roth spot DOID:865 HP:0002633 ORPHA:52759 SNOMEDCT:31996006 Inflammation of blood vessel RCOphth vasculitis DOID:1727 HP:0012636 ICD10:H34.8 SNOMEDCT:68478007 readcode:XE15w Blockage of the retinal vein RCOphth retinal vein occlusion HP:0007985 Blockage of retinal arteriole, generally associated with interruption of blood flow and oxygen delivery to affected regions of the retina RCOphth retinal arteriole occlusion HP:0030666 Involves the sprouting of new vessels from pre-existent vessels to repair or replace damaged vessels RCOphth retinal neovascularisation RCOphth optic disc signs SNOMEDCT:247225001 readcode:X75oS The cup-to-disc ratio compares the diameter of the cup portion of the optic disc with the total diameter of the optic disc RCOphth cup-disc ratio RCOphth features suspicious of glaucoma RCOphth disc colour The margin of the optic disc is a clinical construct that the retinal ganglion cell axons pass through to enter the optic nerve RCOphth disc margin RCOphth disc haemorrhage RCOphth disc vessel RCOphth lens signs RCOphth phakic status RCOphth lens stability RCOphth vitreous signs HP:0030661 SNOMEDCT:417393008 Yellow-white inflammatory aggregates in the vitreous that are found in the midvitreous and inferior periphery RCOphth vitreous snowball RCOphth pars plana exudate HP:0007902 Bleeding within the vitreous compartment of the eye RCOphth vitreous haemorrhage PVD HP:0001489 ICD10:H43.8 SNOMEDCT:247081001 readcode:X75l7 Separation of the vitreous humor from the retina RCOphth posterior vitreous detachment Olivia's Vision RCOphth macula signs RCOphth other macular pathology RCOphth exudative RCOphth tractional effective efficacy Olivia's Vision HP:0012372 HPO abnormal inflammation eye morphology SUN vitreous haze 0 SUN vitreous haze 1+ SUN vitreous haze 2+ SUN vitreous haze 3+ SUN vitreous haze 4+ eosinophilia types of therapy second line steroid sparing immunosuppressive Olivia's Vision biologic biologic therapy Olivia's Vision intraocular pressure lowering agent pain killers pain relief analgesia Olivia's Vision pupil dilating therapy dose procedure SNOMEDCT:71388002 route of administration Olivia's Vision anti-TNF anti-interleukin-6 receptor anti-CD20 anti-VEGF lucentis SNOMEDCT:422456007 ranibizumab Olivia's Vision SNOMEDCT:703840003 aflibercept laser SNOMEDCT:169425004 readcode:5B42 Treatments for retinal diseases retinal laser therapy Olivia's Vision NSAID non-steroidal anti-inflammatory Olivia's Vision advil motrin SNOMEDCT:387207008 ibuprofen Olivia's Vision opiate-based analgesia SNOMEDCT:373529000 readcode:Xa1bA morphine SNOMEDCT:387494007 codeine SNOMEDCT:386858008 tramadol SNOMEDCT:387517004 paracetamol SNOMEDCT:31709000 antineutrophil cytoplasmic antibody SNOMEDCT:372832002 atropine cyclopental cyclopentol mydrilate SNOMEDCT:372869004 cyclopentolate Olivia's Vision SNOMEDCT:372771005 phenylephrine DOID:1731 HP:0032256 ICD10:B39 ORPHA:390 SNOMEDCT:12962009 A disease caused by the fungus Histoplasma sp. Affects the lungs but can also affect additional organs, has symptoms similar to those of a cold or flu and it usually resolves without treatment in healthy individuals, if affected other organs it is generally fatal if untreated histoplasma DOID:526 ICD10:B20 SNOMEDCT:19030005 readcode:Xa0ye A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers human immunodeficiency virus eye injection SNOMEDCT:800481000000101 Injection into the eye intravitreal Olivia's Vision SNOMEDCT:32282008 Under the skin subcutaneous SNOMEDCT:264206001 readcode:XC0Md Under the conjunctiva sub-conjunctival anti-IL-12/23 anti-interleukin-12/23 SNOMEDCT:443465002 ustekinumab HP:0000553 Abnormality of the uvea, the vascular layer of the eyeball HPO abnormal uvea morphology HP:0000610 Any structural abnormality of the choroid HPO abnormal choroid morphology HP:0000532 An abnormality of the choroid and retina HPO abnormal chorioretinal morphology HP:0007858 HPO choriorentinal lacunae HP:0007731 HPO choriorentinal dysplasia HP:0025567 HPO central serous chorioretinopathy HP:0007661 HPO abnormality of chorioretinal pigmentation HP:0000567 HPO chorioretinal coloboma HP:0001135 HPO chorioretinal dystrophy HP:0200065 HPO chorioretinal degeneration HP:0000533 HPO chorioretinal atrophy HP:0007777 HPO chorioretinal scar HP:0011506 HPO choroidal neovascularization HP:0031239 HPO extrafoveal choroidal neovascularization HP:0031240 HPO juxtafoveal choroidal neovascularization HP:0031241 HPO subfoveal choroidal neovascularization SNOMEDCT:73761001 readcode:XM0By colonoscopy HP:0007376 HPO abnormality of the choroid plexus HP:0030952 HPO birdshot choroidal lesions systemic clinical sign HP:0001945 SNOMEDCT:386661006 SYMP:0000613 Elevated body temperature due to failed thermoregulation fever SYMP:0000313 joint inflammation HP:0000988 SNOMEDCT:424223007 SYMP:0000487 A red eruption of the skin skin rash oral ulcer HP:0003249 genital ulcer HP:0000525 Any structural abnormality of the iris HPO abnormal iris morphology HP:0008034 HPO abnormal iris pigmentation HP:0007905 HPO abnormal iris vasculature HP:0000615 HPO abnormal pupil morphology grade RCOphth grade system Olivia's Vision SNOMEDCT:280589009 UBERON:0010292 readcode:Xa1TV Composed of loose, fibrous, elastic tissue UBERON episclera DOID:437 ICD10:G70.0 ORPHA:589 SNOMEDCT:91637004 A rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles myasthenia gravis HP:0100693 HPO iridodonesis HP:0001089 HPO iris atrophy UBERON:0001032 Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information UBERON sensory system SNOMEDCT:57645008 UBERON:0004456 readcode:XS0nB Sum of all sensory systems in an organism UBERON entire sense organ system clinical sign biopsy DOID:7807 HP:0012054 ICD10:C69.3 SNOMEDCT:255021005 readcode:X78bw choroidal melanoma SNOMEDCT:91723000 UBERON:0000061 Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome UBERON anatomical structure HP:0025358 HPO uveal ectropion UBERON:0010000 An anatomical structure that has more than one cell as a part UBERON multicellular anatomical structure pathology inflammatory disorder Olivia's Vision DOID:13452 HP:0100532 ICD10:H15.0 ICD9:379.00 SNOMEDCT:78370002 readcode:F4K0 readcode:X00aC Inflammation of the sclera scleritis UBERON:0000468 Anatomical structure that is an individual member of a species and consists of more than one cell UBERON multicellular organism pink eye HP:0000509 ICD10:H10 SNOMEDCT:9826008 readcode:F4C0 Inflammation of the conjunctiva RCOphth conjunctivitis Olivia's Vision HP:0000491 ICD10:H16 ICD9:370 SNOMEDCT:5888003 readcode:XE16N Inflammation of the cornea keratitis HP:0001096 ICD10:H16.2 ICD9:370.2 readcode:F4A readcode:X00ah Inflammation of the cornea and conjunctiva HPO keratoconjunctivitis HP:0011859 ICD10:H16.1 ICD9:370.21 SNOMEDCT:42513006 readcode:F4A21 A type of keratitis characterized by inflammation in pinpoint areas of the corneal epithelium HPO punctate keratitis HP:0007879 readcode:F4C14 Allergic Conjunctivitis is an allergic inflammation of the conjunctiva HPO allergic conjunctivitis HP:0007717 ICD10:H10.4 ICD9:372.1 readcode:F4C1 Commonly presents with general irritation and redness of the eyes, with a burning, dry, or foreign-body sensation of the eyes HPO chronic irrative conjunctivitis UBERON:0000475 Anatomical structure which is a subdivision of a whole organism UBERON organism subdivison DOID:6523 HP:0012055 ICD10:C69.4 SNOMEDCT:255015006 readcode:X78bk ciliary body melanoma UBERON:0001444 UBERON subdivision of head HP:0012373 HPO abnormal inflammation eye physiology SNOMEDCT:371398005 UBERON:0004088 The subdivision of the face that includes the eyeball and adnexa, such as eyelids UBERON orbital region ORPHA:324625 SNOMEDCT:2423009 readcode:X73kl chikungunya with aquaporin-4 antibodies IOP pressure HP:0012632 HPO abnormal intraocular pressure Olivia's Vision HP:0007686 HPO abnormal pupillary function HP:0007695 HPO abnormal pupillary light reflex HP:0000616 HPO miosis dilated HP:0011499 PATO:0001571 SNOMEDCT:37125009 readcode:Xa88T mydriasis Olivia's Vision HP:0012074 HPO tonic pupil without aquaporin-4 antibodies thyroid disease SNOMEDCT:44888004 UBERON:0035639 The parts of the orbital region that are outside of the the eyeball UBERON ocular adnexa SNOMEDCT:392262008 UBERON:0010163 The eyebrow is an area of thick, delicate hairs above the eye that follows the shape of the lower margin of the brow ridges - their main function is to protect the eye, but they are also important to human communication and facial expression UBERON eyebrow UBERON:0015152 A gland that is typically found in or near the orbital region and is typically associated with secretions onto the eyeball or associated ducts UBERON gland of ocular region UBERON:0003605 UBERON eye skin gland SNOMEDCT:280574000 UBERON:0013229 readcode:Xa1TA UBERON eyelid gland SNOMEDCT:314802006 UBERON:0015154 UBERON lateral gland of orbital region SNOMEDCT:13561001 UBERON:0001817 The lacrimal glands are paired almond-shaped glands, located in or near the orbital region, that secrete the aqueous layer of the tear film UBERON lacrimal gland UBERON:0015153 UBERON medial gland of ocular region UBERON:0004187 The Harderian gland is an anterior orbital gland usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye UBERON harderian gland SNOMEDCT:80243003 UBERON:0001711 A fold of skin that covers and protects part of the eyeball UBERON eyelid UBERON:0011676 A major subdivision of an organism that divides an organism along its main body axis UBERON subdivision of organism along main body axis SNOMEDCT:69536005 UBERON:0000033 The head is the anterior-most division of the body UBERON head UBERON:0034713 Any of the cranial nerves, or their central nervous system analogs UBERON cranial neuron projection bundle UBERON:0004904 A neuron projection bundle that connects the retina or its analog in the eye with the brain UBERON neuron projection bundle connecting eye with brain SNOMEDCT:25087005 UBERON:0001016 The nervous system is an organ system - it is arranged in a network of tree-like structures connected to a central body with the main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior UBERON nervous system UBERON:0000122 UBERON neuron projection bundle UBERON:0007418 UBERON neural decussation vision HP:0000504 HPO abnormality of vision Olivia's Vision HP:0032036 An abnormality in perception of contrast. Spatial contrast is a physical dimension referring to the light-dark transition of a border or an edge in an image that delineates the existence of a pattern or an object. Contrast sensitivity refers to a measure of how much contrast a person requires to see a target HPO abnormal contrast sensitivity HP:0011514 An abnormality of binocular vision, that is of the ability to synthesize the visual inputs from both eyes to a single image with perception of depth HPO abnormal binocular vision HP:0000551 An anomaly in the ability to discriminate between or recognise colors HPO colour vision defect HP:0030512 HPO difficulty adjusting to changes in luminance HP:0025152 HPO poor visual behaviour for age visual difficulty HP:0000505 SNOMEDCT:397540003 Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery HPO visual impairment Olivia's Vision HP:0000572 ICD10:H53.8 SNOMEDCT:246656009 readcode:X75bz Loss of visual acuity HPO visual loss HP:0001123 ICD10:H53.4 SNOMEDCT:12184005 HPO visual field defect HP:0000575 SNOMEDCT:23388006 A regional and pathological increase of the light detection threshold in any region of the visual field surrounded by a field of normal or relatively well-preserved vision HPO scotoma HP:0007663 HPO reduced visual acuity UBERON:0007425 A neural decussation that is part of a diencephalon UBERON decussation of diencephalon bleeding HP:0011885 HPO hemorrhage of the eye Olivia's Vision HP:0011887 HPO choroid hemorrhage HP:0031803 HPO fundus hemorrhage HP:0000573 HPO retinal hemorrhage HP:0007902 HPO vitreous hemorrhage ICD10:H47.4 SNOMEDCT:70476006 UBERON:0000959 A decussation of the diencephalon where the fibers of the optic nerve cross UBERON optic chiasma ICD10:H45.1 ORPHA:199323 SNOMEDCT:1847009 readcode:X00eY A purulent inflammation of the intraocular fluids (vitreous and aqueous) usually due to infection endophthalmitis ICD10:H44.0 ICD9:360.01 ORPHA:279888 SNOMEDCT:1493002 readcode:F4001 Refers to endophthalmitis shortly after ocular surgery - initial symptoms: rapidly progressive, including pain, red eye, ocular discharge, and blurring ORDO acute endophthalmitis ICD10:H44.0 ICD9:360.03 ORPHA:279891 SNOMEDCT:13978000 readcode:F4003 A delayed infectious intraocular inflammation process that occurs more after ocular surgery ORDO chronic endophthalmitis ORPHA:449563 A rare, inflammatory eye disease characterized by IgG4-immunopositive lymphocyte and plasmacyte infiltration and collagenous fibrosis of affected tissue and elevated serum levels of IgG4 ORDO IgG4-related opthalmic disease DOID:0050214 ICD10:G73.1 ORPHA:43393 SNOMEDCT:56989000 readcode:F3810 Lambert-Eaton myasthenic syndrome is an autoimmune, presynaptic disorder of neuromuscular transmission lambert-eaton myasthenic syndrome DOID:12894 ICD10:M35.0 An autoimmune hypersensitivity disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva sjogren syndrome SNOMEDCT:276177000 thyroid eye disease ORPHA:158014 A rare benign non-Langerhans cell histiocytosis characterized by the development of large painless histiocytic masses in the lymph nodes, predominantly of the cervical region rosai-dorfman disease DOID:9423 HP:0000498 ICD10:H01.0 ICD9:373.0 SNOMEDCT:41446000 readcode:F4D0 Inflammation of the eyelids blepharitis DOID:13676 ICD9:379.07 SNOMEDCT:267660007 readcode:XE171 Posterior scleritis is defined as involvement of the sclera posterior to the insertion of the rectus muscles DOID posterior scleritis DOID:13861 ICD9:379.05 SNOMEDCT:42574005 Scleroperikeratitis is also known as scleritis with corneal involvement DOID scleroperikeratitis peripheral scars of retina RCOphth central dislocating DOID:11364 HP:0001132 ICD10:H27.1 SNOMEDCT:65814009 readcode:F4K31 Partial dislocation of the lens of the eye RCOphth subluxed Olivia's Vision SNOMEDCT:363959004 RCOphth clear crystalline lens IOL SNOMEDCT:313236002 Pseudophakia means “fake lens.” It's a term that's used after you've had an artificial lens implanted in your eye to replace your own natural lens RCOphth pseudophakic Olivia's Vision RCOphth aphakic RCOphth other choroidal lesions CDR 0 CDR 0.1 CDR 0.2 CDR 0.3 CDR 0.4 CDR 0.5 RCOphth normal RCOphth hyperaemic RCOphth pallor disc edema ICD10:H47.1 SNOMEDCT:423341008 Swelling of the optic disc with a concurrent increase in fluid within or surrounding the axons RCOphth disc oedema RCOphth disc collateral RCOphth NVD RCOphth fibrin SNOMEDCT:75229002 readcode:X75j2 RCOphth hyphaema ICD10:H35.0 SNOMEDCT:75971007 The creation of new blood vessels in the choroid layer RCOphth CNV membrane HP:0200056 ICD10:H31.0 SNOMEDCT:18410006 Scar tissue in the macula RCOphth scar RCOphth atrophy Used in people who have developed new abnormal blood vessels at the back of the eye in the retina or in the drainage system within the eyeball pan retinal photocoagulaion sectoral laser sectoral retinal laser photocoagulation HP:0025609 HPO anterior blepharitis IBD DOID:0050589 SNOMEDCT:24526004 Chronic inflammation of your digestive tract inflammatory bowel disease Olivia's Vision DOID:8778 HP:0100280 ICD10:K50 SNOMEDCT:34000006 A chronic granulomatous inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea which may be bloody, vomiting, or weight loss, but may also cause complications outside of the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness, and lack of concentration crohn's UC DOID:8577 HP:0100279 ICD10:K51 SNOMEDCT:64766004 A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon ulcerative colitis Olivia's Vision reactive arthritis DOID:6196 ICD10:M02.3 SNOMEDCT:67224007 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body reiter's syndrome Olivia's Vision needle RCOphth injection Olivia's Vision SNOMEDCT:409276006 betaxolol SNOMEDCT:386866004 carteolol SNOMEDCT:418934007 levobunolol SNOMEDCT:15737241000119105 A complication that can occur sometime after cataract surgery, can make it seem as though cataracts have returned, but it can be easily treated with a quick, painless, outpatient laser procedure to make vision clear again posterior capsule opacification implant into vitreous cavity iluvien retisert flucinolone acetonide Olivia's Vision SNOMEDCT:250428009 readcode:X76y2 anti-microbial SNOMEDCT:372701006 anti-viral SNOMEDCT:372848001 ganciclovir acyclovir SNOMEDCT:372729009 readcode:x05K1 aciclovir Olivia's Vision SNOMEDCT:372902006 foscarnet valcyte SNOMEDCT:129476000 valganciclovir SNOMEDCT:96098007 valacyclovir SNOMEDCT:767570008 anti-parasitic SNOMEDCT:387531004 readcode:x05Lc azithromycin SNOMEDCT:373769001 pyrimethamine SNOMEDCT:74523009 sulfadiazine SNOMEDCT:419241000 anti-bacterial SNOMEDCT:372478003 doxycycline SNOMEDCT:372809001 tetracycline SNOMEDCT:387472004 isoniazid SNOMEDCT:387159009 rifampicin SNOMEDCT:387076005 pyrazinamide SNOMEDCT:387129004 ethambutol fluroquinolone SNOMEDCT:387552007 levofloxacin SNOMEDCT:412439003 moxifloxacin SNOMEDCT:763805006 aminoglycoside SNOMEDCT:387266001 readcode:x05Km amikacin SNOMEDCT:301844007 readcode:Xa86a glycopeptide vancocin SNOMEDCT:372735009 vancomycin SNOMEDCT:428787002 macrolide SNOMEDCT:406778007 beta-lactam SNOMEDCT:387487009 clarithromycin SNOMEDCT:764146007 Work by indirectly bursting bacterial cell walls penicillin SNOMEDCT:764147003 They bind to and block the activity of enzymes responsible for making peptidoglycan, an important component of the bacterial cell wall cephalosporin sulfa anitbiotic SNOMEDCT:373219008 anti-fungal amphoteracin B VFEND SNOMEDCT:385469007 voriconazole SNOMEDCT:41296002 UBERON:0001769 The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye UBERON iris HP:0032037 SNOMEDCT:397543001 readcode:XaYiO Mild reduction of the ability to see defined as visual acuity less than 6/12 but at least 6/18 HPO mild vision impairment HP:0030515 SNOMEDCT:397542006 Moderate reduction of the ability to see defined as visual acuity less than 6/18 but at least 6/60 HPO moderate vision impairment HP:0001141 SNOMEDCT:397541004 Severe reduction of the ability to see defined as visual acuity less than 6/60 but at least 3/60 HPO severe vision impairment HP:0000618 ICD10:H54.0 SNOMEDCT:105597003 SYMP:0000008 Olivia's Vision blind CDR 0.6 CDR 0.8 CDR 0.7 CDR 0.9 CDR 1.0 DOID:1210 HP:0100653 ICD10:H46 ICD9:377.3 SNOMEDCT:66760008 readcode:XE19X Inflammation of the optic nerve optic neuritis HP:0025610 HPO posterior blepharitis DOID:633 HP:0100614 ICD10:H05.1 ICD9:376.12 SNOMEDCT:80698001 readcode:F4G12 A myopathy characterized by muscle inflammation orbital myositis ICD10:H05.0 ICD9:376.01 SNOMEDCT:194005002 readcode:F4G01 orbital cellulitis SYMP:0000258 double vision ICD10:H53.1 SNOMEDCT:7751009 readcode:F4818 discomfort ICD10:H57.8 SNOMEDCT:74776002 itchy ICD10:H04.2 SNOMEDCT:420103007 readcode:XE0s4 watery eye SNOMEDCT:113091000 Magnetic resonance imaging MRI SNOMEDCT:241645008 readcode:X70pC MRI spine SNOMEDCT:30957007 readcode:X70oP MRI orbit SNOMEDCT:303678006 readcode:Xa9fH Computed tomography scan CT scan SNOMEDCT:303653007 CT head SNOMEDCT:241520004 readcode:X70n1 CT orbit DOID:9120 HP:0011034 ICD10:E85 ORPHA:69 SNOMEDCT:89449005 The presence of amyloid deposition in one or more tissues amyloidosis ICD10:H04.1 PATO:0001824 SNOMEDCT:162290004 A wetness quality inhering in a bearer by virtue of the bearer's not being covered by a liquid dry eye low pressure DOID:790 ICD10:H44.4 SNOMEDCT:19721008 ocular hypotension Olivia's Vision x ray xray SNOMEDCT:303927002 Plain film of body region x-ray Olivia's Vision ICD10:L98.4 SNOMEDCT:429040005 ulcer ICD10:D68.6 SNOMEDCT:26843008 readcode:X704i antiphospholipid syndrome DOID:0060216 ICD10:H16.3 SNOMEDCT:405810005 readcode:X00an cogan's syndrome DOID:10608 ICD10:K90.0 SNOMEDCT:396331005 coeliac disease ORPHA:397 SNOMEDCT:414341000 GCA giant cell arteritis DOID:11123 HSP henoch-schoenlein purpura DOID:13189 HP:0001997 ICD10:M10.9 SNOMEDCT:90560007 gout ICD10:T86.0 ORPHA:39812 SNOMEDCT:234646005 readcode:X20Ir graft-versus-host disease SNOMEDCT:236407003 readcode:X30IQ IgA nephropathy DOID:12306 HP:0001045 ICD10:L80 SNOMEDCT:56727007 readcode:M2951 vitiligo SNOMEDCT:35562000 readcode:XaBLz waldenstrom's macroglobulinaemia DOID:853 ORPHA:93569 SNOMEDCT:65323003 readcode:XE1FJ polymyalgia rheumatica DOID:13268 ORPHA:738 SNOMEDCT:418470004 porphyria DOID:2556 ICD10:M94.1 ORPHA:728 SNOMEDCT:72275000 readcode:N33z5 relapsing polychondritis DOID:0050426 ICD10:L51.1 ORPHA:36426 SNOMEDCT:73442001 stevens-johnson syndrome DOID:865 HP:0002633 ORPHA:52759 SNOMEDCT:31996006 vasculitis ORPHA:838 susac syndrome DOID:2987 ICD10:E85.0 ORPHA:342 SNOMEDCT:12579009 readcode:C3731 familial mediterranean fever amoebae SNOMEDCT:50875003 readcode:X73nk acanthamoeba DOID:11077 ORPHA:1304 SNOMEDCT:75702008 brucellosis brucella DOID:13276 ICD10:J15.7 SNOMEDCT:46970008 readcode:A3By4 mycoplasma pneumonia mycoplasma pneumoniae DOID:1024 ORPHA:548 SNOMEDCT:81004002 leprosy mycobacterium leprae DOID:13036 ICD10:A68.1 SNOMEDCT:10301003 tick borne fever rickettsia SNOMEDCT:41545003 whipple's disease tropheryma whippelii DOID:0080599 SNOMEDCT:186747009 coronavirus DOID:12205 ORPHA:99828 SNOMEDCT:34348001 readcode:X73l4 dengue virus DOID:2043 SNOMEDCT:81665004 readcode:X73k1 hepatitis B DOID:1883 SNOMEDCT:62944002 readcode:X73lC hepatitis C DOID:8622 SNOMEDCT:14189004 measles rubeola virus DOID:10264 SNOMEDCT:50384007 readcode:X73lO mumps virus DOID:8781 SNOMEDCT:5210005 readcode:X73ku german measles rubella virus DOID:2366 SNOMEDCT:57311007 readcode:X73l2 west nile virus DOID:0060478 ORPHA:448237 SNOMEDCT:50471002 readcode:XaDr9 zika virus coxiella virus larva of various species Ocular Immune-Mediated Inflammatory Disease Ontology Alastair K Denniston Georgios V Gkoutos Luke T Slater Samantha C Pendleton Tasanee Braithwaite DOID HPO ORDO Olivia's Vision PATO SNOMED-CT The Royal College of Ophthalmologists Uveitis Dataset 2018 UBERON https://github.com/sap218/ocimido https://creativecommons.org/licenses/by/3.0/ version 1.2.0