BFO 2 Reference: BFO does not claim to provide complete coverage of entities of all types. It seeks only to provide coverage of those entities studied by empirical science together with those entities which affect or are involved in human activities such as data processing and planning - coverage that is sufficiently broad to provide assistance to those engaged in building domain ontologies for purposes of data annotation. BFO 2 Reference: BFO's treatment of continuants and occurrents - as also its treatment of regions, rests on a dichotomy between space and time, and on the view that there are two perspectives on reality - earlier called the 'SNAP' and 'SPAN' perspectives, both of which are essential to the non-reductionist representation of reality as we understand it from the best available science. BFO 2 Reference: For both terms and relational expressions in BFO, we distinguish between primitive and defined. 'Entity' is an example of a primitive term. Primitive terms in a highest-level ontology such as BFO are terms that are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms. Alan Ruttenberg Albert Goldfain Barry Smith Bill Duncan Bjoern Peters Chris Mungall David Osumi-Sutherland Fabian Neuhaus Holger Stenzhorn James A. Overton Janna Hastings Jie Zheng Jonathan Bona Larry Hunter Leonard Jacuzzo Ludger Jansen Mark Ressler Mathias Brochhausen Mauricio Almeida Melanie Courtot Pierre Grenon Randall Dipert Ron Rudnicki Selja Seppälä Stefan Schulz Thomas Bittner Werner Ceusters Yongqun "Oliver" He Akshaye Dhawan Prabhu Shankar Rajshekar Sunderraman Rani Singh Sham Navathe Sivaram Arabandi Snežana Nikolić 2014-09-03 Ontology for Newborn Screening Follow-up and Translational Research (ONSTR) is an application ontology covering data items, processes and agents involved in practices of newborn screening, short- and long-term follow-up of patients with inheritable and congenital disorders and related translational research. RDF/XML Keywords: biomedical ontology, neborn screening, inherited metabolic disorders, translational research, metabolism, genetic disorders, health care, public health, nutrition, diet. Ontology for Newborn Screening Follow-up and Translational Research As of ONSTR v0.4 (this version), active ontology development has been discontinued. For more information about this ontology please contact ONSTR/NBSDC project PI Dr. Rani Singh (rsingh@emory.edu) or Snezana Nikolic (snez.sn@gmail.com). For release notes please see http://onstr.googlecode.com/svn/tags/currentRelease/2014-09-03/ ONSTR v0.4 is based on the SVN checkout r641. Please see the project site https://github.com/BFO-ontology/BFO, the bfo2 owl discussion group http://groups.google.com/group/bfo-owl-devel, the bfo2 discussion group http://groups.google.com/group/bfo-devel, the tracking google doc http://goo.gl/IlrEE, and the current version of the bfo2 reference http://purl.obolibrary.org/obo/bfo/dev/bfo2-reference.docx. This ontology is generated from a specification at https://github.com/BFO-ontology/BFO/tree/master/src/ontology/owl-group/specification/ and with the code that generates the OWL version in https://github.com/BFO-ontology/BFO/tree/master/src/tools/. A very early version of BFO version 2 in CLIF is at http://purl.obolibrary.org/obo/bfo/dev/bfo.clif. The BSD license on the BFO project site refers to code used to build BFO. This BFO 2.0 version represents a major update to BFO and is not strictly backwards compatible with BFO 1.1. The previous OWL version of BFO, version 1.1.1 will remain available at http://ifomis.org/bfo/1.1 and will no longer be updated. The BFO 2.0 OWL is a classes-only specification. The incorporation of core relations has been held over for a later version. 0.4 ONSTR Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. Really of interest to developers only BFO OWL specification label Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 Person:Alan Ruttenberg Really of interest to developers only BFO CLIF specification label editor preferred term example of usage definition editor note term editor alternative term definition source curator note imported from elucidation has associated axiom(nl) has associated axiom(fol) has axiom label has produced datum has specified input A relation between a planned process and a continuant participating in that process where a continuant is an input to a given planned proces. Curation status: Incomplete NOTE: This is a TEMPORARY relation that will be replaced by the corresponding (or more appropriate) OBI relation, once OBI migrates under newer version of BFO2 (BFO2 vGraz, or newer). is information content entity collected during process Relation between an information content entity and a process during which a datum has been collected or recorded. has informational basis A data item d1 has information basis data item d2 means that there was a process of data interpretation by which a d1 is characterized by using d2, and d2 was an input to the data interpretation process. has specified output A relation between a planned process and a continuant participating in that process where a continuant is an output of a given planned proces. Curation status: Incomplete NOTE: This is a TEMPORARY relation that will be replaced by the corresponding (or more appropriate) OBI relation, once OBI migrates under newer version of BFO2 (BFO2 vGraz, or newer). is datum produced by A relation between a software application and a datum, where the datum is produced as an output of the data transformation process (or processes) that are a part of the execution of the software instructions by a processing unit. is specified input of A relation between a continuant that is an input of a process and a planned process. NOTE: This is a TEMPORARY relation that will be replaced by the corresponding (or more appropriate) OBI relation, once OBI migrates under newer version of BFO2 (BFO2 vGraz, or newer). This is the inverse relation of temporary relation has specified input (ONSTR_1111111). is informational basis of has information content entity collection process is specified output of A relation between a continuant that is an output of a process and a planned process. NOTE: This is a TEMPORARY relation that will be replaced by the corresponding (or more appropriate) OBI relation, once OBI migrates under newer version of BFO2 (BFO2 vGraz, or newer). This is the inverse relation of temporary relation has specified input (ONSTR_2222222). has time measurement datum A relation between time stamped measurement datum and time measurement datum. is preceded by precedes has measurement unit label Curation status: Imported from Information Artifact Ontology (IAO). NOTE: This is imported relation that is currently placed under relation 'has part' (BFO_0000051) which does not exist in the latest version of BFO2. For the time being (i.e. until team IAO places it under appropriate BFO2 relation), we are placing it under 'has proper continuant part of', because this seems to be the most suitable place for it in the latest BFO2 relation hierarchy. The position of this relation will be adjusted if/when team IAO makes the necessary change. [SN:Aug01-2012] is about is about is a (currently) primitive relation that relates an information artifact to an entity. Curation status: Imported from Information Artifact Ontology (IAO). denotes Denotes is a primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically. Curation status: Imported from Information Artifact Ontology (IAO). A person's name denotes the person. A variable name in a computer program denotes some piece of memory. Lexically equivalent strings can denote different things, for instance "Alan" can denote different people. In each case of use, there is a case of the denotation relation obtaining, between "Alan" and the person that is being named. is quality measurement of m is a quality measurement of q at t when q is a determinable quality there is a measurement process p that has_output m m has a value part that together with the units of the value of q at t. p is a assay assay: process and has_input some material entity and has_output some information content entity and which is such that instances of this process type reliably generate outputs that describes the input. a is a magnitude means a is a determinate quality particular inhering in some bearer b existing at a time t that can be represented/denoted by an information content entity e that has parts denoting a unit of measure, a number, and b. The unit of measure is an instance of the determinable quality. unit of measure is a quality, e.g. the length of a ruler. a represents b means either a denotes b or a describes describe: a describes b means a is about b and a allows an inference of at least one quality of b Example: q = height of barry p is the process using a tape measure extend across the longer part of barry and reading off the number at the far end. v is that number # dimension is height unit of measure is inches We have had a long discussion about denotes versus describes. Curation status: Imported from Information Artifact Ontology (IAO). has time stamp Relates a time stamped measurement datum to the time measurement datum that denotes the time when the measurement was taken. Imported from Ontology for Information Artifact Ontology (IAO). has measurement datum Relates a time stamped measurement datum to the measurement datum that was measured. Imported from Ontology for Information Artifact Ontology (IAO). achieves_planned_objective This relation obtains between a planned process and an objective specification when the criteria specified in the objective specification are met at the end of the planned process. Imported from the Ontology for Biomedical Investigation (OBI). objective_achieved_by This relation obtains between a a objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process. Imported from the Ontology for Biomedical Investigation (OBI). has category label towards A relation between a relational quality and an independent continuant, subproperty of inheres that distinguishes the main bearers of a relational quality from additional dependents. Curation status: Imported from OBO_REL This may be deprecated/replaced by a suitable (potentially equivalent) PATO relation. [SN:Aug01-2012] unfolds_in P unfolds_in C : the execution of P is spatially contained by C. forall pP, forall c' partipates_in p, c' located_in C at t, for some t in P Curation status: Imported from OBO_REL Note: In PATO the domain and range for this object property are "quality" PATO_0000001, a class which technically overlaps with BFO2 class "quality" BFO_0000019 which is, therefore, in this ontology asserted as domain and range for directly_associated_with. directly_associated_with q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear. Curation status: Imported from Phenotypic Quality Ontology (PATO). Example: 'Lewy bodies increased number related to dystrophic neurite increased number' (from annotation of PMID:8740227 in http://ccdb.ucsd.edu/1.0/NDPO.owl#ndpo_404). Here the increase in the number of lewy bodies is directly_associated_with the increase in the number of dystrophic neurites.nAssociation is weaker than correlation or proportionality. These relations may be later added to PATO. [Source: PATO.] Derivation as a relation between instances. The temporal relation of derivation is more complex. Transformation, on the instance level, is just the relation of identity: each adult is identical to some child existing at some earlier time. Derivation on the instance-level is a relation holding between non-identicals. More precisely, it holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. Thus we will have axioms to the effect that from c derives_from c1 we can infer that c and c1 are not identical and that there is some instant of time t such that c1 exists only prior to and c only subsequent to t. We will also be able to infer that the spatial region occupied by c as it begins to exist at t overlaps with the spatial region occupied by c1 as it ceases to exist in the same instant. This may be (or very likely will be) removed or replaced at a later date. derives_from Derivation on the instance level (*derives_from*) holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. We say that one class C derives_ass C' if instances of C are connected to instances of C' via some chain of instance-level derivation relations. Example: osteocyte derives_from osteoblast. Formally: C derives_immediately_from C' if and only if: given any c and any t, if c instantiates C at time t, then there is some c' and some t', such that c' instantiates C' at t' and t' earlier-than t and c *derives_from* c'. C derives_from C' if and only if: there is an chain of immediate derivation relations connecting C to C'. Curation status: Imported from Relation Ontology (RO) Definition source: W3C XML Schema Definition Language (XSD) 1.1 Part 2: Dataypes. W3C Recommendation 5 April 2012, retrievable from http://www.w3.org/TR/2012/REC-xmlschema11-2-20120405/ Intended to be used for data item instance values such as names, labels, symbols and/or similar kind of identifiers for which strings of alphanumeric characters are commonly used. For instance, country name "Canada" or nutritional formula name "Ketonex-2", patient ID "SNDM01234567". Strictly speaking, XML Schema (XSD) data type xsd:string and xsd:Name, among alphabetical characters also include numeral characters, hyphen, underscore etc. However, such non-alphabetical kinds of character strings like numeral character "3" in character string "W3C" or "4" in "4Hero", do not represent numbers (i.e. computable mathematical entities) which are in XSD represented by numerical datatypes like xsd:decimal or xsd:float. has alphanumerical value has literal value Has alphanumerical value is a datatype property intended to be used for data items that in part or in whole include a string of zero or more alphanumeric characters that together represent a stretch of human readable, but not necessarily, natural language material. Curation status: Incomplete Definition source: W3C XML Schema Definition Language (XSD) 1.1 Part 2: Dataypes. W3C Recommendation 5 April 2012, retrievable from http://www.w3.org/TR/2012/REC-xmlschema11-2-20120405/ Intended to be used for data item instance values of numerical type that are not linked by "has measurement value" (obo:IAO_0000004), since the domain of "has measurement value" is restricted to ("scalar measurement datum" (obo:IAO_0000032). This works for instances of classes such as "developmental growth indicator" (ONSTR_7867655). has numerical value has number value Has numerical value is a datatype property intended to be used for data item instance values that in part or in whole include string of numeral characters (also known as Hindu-Arabic numerals or Arabic numerals or Western numerals) that represent numbers and that are computable. Curation status: Incomplete Definition source: W3C XML Schema Definition Language (XSD) 1.1 Part 2: Dataypes. W3C Recommendation 5 April 2012, retrievable from http://www.w3.org/TR/2012/REC-xmlschema11-2-20120405/ Note: Standard xsd:date datatype form is YYYY-MM-DD (e.g. 2012-12-24), not MM-DD-YYYY or DD-MM-YYYY as customary in certain parts of the world. has date value Has date value is a datatype property intended to be used for data item instances referring to specific days counted in accordance with the Julian calendar, such as date of birth, date of follow-up visit etc. Curation status: Incomplete has measurement value Curation status: Imported from Information Artifact Ontology (IAO).from Information Artifact Ontology (IAO). ONSTR:ONSTR_0001776 Definition source: ONSTR curators. adequate nutrient intake for female population age 9-to-13 years Adequate nutrient intake for female population age 9-to-13 years is an adequate nutrient intake for non-pregnant non-lactating female population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy female population 9 to 13 years of age. Curation status: Incomplete ONSTR:ONSTR_0003002 Definition source: ONSTR curators. average daily dietary vitamin D intake per body mass during observed time interval Average daily dietary vitamin D intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of vitamin D contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_0010450 Definition source: ONSTR curators percent upper tolerable methionine intake level datum Percent upper tolerable methionine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid methionine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for methionine. Curation status: Incomplete ONSTR:ONSTR_0011550 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 boys birth-to-36-months weight-for-age percentile chart Weight-for-age percentiles: Boys, birth to 36 months boys weight-for-age birth to 36 months percentile chart Boys birth-to-36-months weight-for-age percentile chart is a birth-to-36-months weight-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of weight measurement data (body mass measurements) with respect to age in a population of healthy boys 0 to 36 months of age. Curation status: Incomplete 20.0 1200.0 ONSTR:ONSTR_0014697 Definition source: ONSTR curators. classic PKU hyperphenylalaninemia finding Classic PKU hyperphenylalaninemia finding is a hyperphenylalaninemia finding based on the value of blood phenylalanine concentration measurement datum or plasma phenylalanine concentration measurement datum that is greater than 1200 μmol/L (or 20 mg/dL). Curation status: Incomplete ONSTR:ONSTR_0032940 Definition source: ONSTR curators. dietary nutrient intake per unit time Dietary nutrient intake per unit time is a derived unit which denotes the quantity of a particular dietary nutrient taken by a human in an time interval denoted by a time unit (usually a day) with or without respect ot human body mass. Curation status: Incomplete ONSTR:ONSTR_0058365 Definition source: ONSTR curators. average daily dietary iron intake per body mass during observed time interval Average daily dietary iron intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval datum denoting the average quantity of dietary iron contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_0058748 Definition source: ONSTR curators. percent recommended dietary biotine allowance Percent recommended dietary biotine allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary biotine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for biotine. Curation status: Incomplete ONSTR:ONSTR_0067271 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm boys head circumference-for-age weight-for-length percentile chart Birth to 36 months: Boys, head circumference-for-age and weight-for-length percentiles boys HC-for-age and weight-for-length percentile chart boys head circumference-for-age and weight-for-length percentile chart Boys head circumference-for-age weight-for-length percentile chart is a head circumference-for-age weight-for-length percentile chart that illustrates the distribution of head circumference measurements with respect to age, and weight (body mass) measurements with respect to body height (length) measurements in a population of healthy boys 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_0072436 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.370-379. high average daily dietary potassium intake high kalium intake high mean kalium intake high mean potassium intake high potassium intake High average daily dietary potassium intake is an average daily dietary potassium intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary potassium (kalium) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0076769 Definition source: ONSTR curators. percent recommended dietary iron allowance Percent recommended dietary iron allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary iron consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for iron. Curation status: Incomplete ONSTR:ONSTR_0077672 Definition source: ONSTR curators percent upper tolerable vitamin intake level datum Percent upper tolerable vitamin intake level is a percent upper tolerable micronutrient intake level that provides the information about the quantity of specific vitamin consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed vitamin. Curation status: Incomplete ONSTR:ONSTR_0087869 Definition source: ONSTR curators. abnormally low phenylalanine-4-hydroxylase activity Abnormally low phenylalanine-4-hydroxylase activity is a phenylalanine-4-hydroxylase activity that under normal physiological conditions (normal cytosolic pH, temperature and substrate saturation) catalyses the conversion of L-phenyalalanine to L-tyrosine at catalytic rate that is considered abnormally low for phenylalanine-4-hydroxylase complex. Curation status: Incomplete ONSTR:ONSTR_0088622 Definition source: ONSTR curators. recommended dietary allowance for female population age 9-to-13 years Recommended dietary allowance for female population age 9-to-13 years is a recommended dietary allowance for non-pregnant non-lactating female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy female population 9 to 13 years of age. Curation status: Incomplete ONSTR:ONSTR_0106524 Definition source: ONSTR curators percent estimated average silicon requirement datum Percent estimated average silicon requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of silicon consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for silicon. Curation status: Incomplete ONSTR:ONSTR_0123063 Definition source: ONSTR curators. newborn nutritional intake datum feeding status feeding type nutrtrition status Newborn nutritional intake datum is a data item that provides the information about the kinds of nutritional items a newborn is beenfed at the time of dried blood spot creation diring the newborn dried blood screening process. Curation status: Incomplete ONSTR:ONSTR_0128089 Definition source: Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.62-63. phenylalanine hydroxylase deficiency PAH deficiency phenylalanine-4-hydroxilase deficiency PAH deficiency is a congenital metabolic disorder characterized by reduced activity (deficiency in activity) of the enzyme phenylalanine-4-hydroxilaze, that is caused by two recessive mutated PAH alleles in the inherited PAH genome. PAH deficiency (and hypephenylalalninemia, and PKU, respectively) has autosomal recessive inheritance pattern with most cases in compound heterozygous state (genetic compound) where both maternal and paternal PAH alleles are differently mutated and present at chromosome 12. Curation status: Incomplete 15.0 20.0 900.0 1200.0 ONSTR:ONSTR_0134074 Definition source: ONSTR curators. moderate PKU hyperphenylalaninemia finding Moderate PKU hyperphenylalaninemia finding is a hyperphenylalaninemia finding based on the value of blood phenylalanine concentration measurement datum or plasma phenylalanine concentration measurement datum falling within the range of 900 - 1200 μmol/L (or 15 - 20 mg/dL). Curation status: Incomplete ONSTR:ONSTR_0138680 Definition source: ONSTR curators percent upper tolerable selenium intake level datum Percent upper tolerable selenium intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of selenium consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for selenium. Curation status: Incomplete ONSTR:ONSTR_0148771 Definition source: ONSTR curators percent adequate proline intake datum Percent adequate proline intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid proline consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for proline. Curation status: Incomplete ONSTR:ONSTR_0153095 Definition source: ONSTR curators. blood plasma homocysteine concentration measurement datum plasma Hcy plasma Hcy level plasma Hcy status plasma homocysteine concentration plasma homocysteine level plasma homocysteine measurement plasma homocysteine status Blood plasma homocysteine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid homocysteine in the human plasma blood specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_0162918 Definition source: ONSTR curators percent adequate phosphorus intake datum Percent adequate phosphorus intake is a percent adequate dietary mineral intake that provides the information about the quantity phosphorus consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for phosphorus. Curation status: Incomplete ONSTR:ONSTR_0164208 Definition source: ONSTR curators. percent recommended dietary selenium allowance Percent recommended dietary selenium allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary selenium consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for selenium. Curation status: Incomplete ONSTR:ONSTR_0184244 Definition source: ONSTR curators. average daily dietary boron intake per body mass during observed time interval Average daily dietary boron intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary boron contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_0193925 Definition source: ONSTR curators. nutrient Nutrient is an object that is a proper part of a nutritional item (food item, dietary supplement, medical food, special nutrition formula or parenteral nutrition solution) that is introduced into and used by an organism to produce energy, build body tissues, stimulate growth and maintain homeostasis. Curation status: Incomplete ONSTR:ONSTR_0201025 Definition source: ONSTR curators percent upper tolerable iodine intake level datum Percent upper tolerable iodine intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of iodine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for iodine. Curation status: Incomplete ONSTR:ONSTR_0205881 Definition source: ONSTR curators percent upper tolerable serine intake level datum Percent upper tolerable serine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid serine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for serine. Curation status: Incomplete ONSTR:ONSTR_0216195 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. normal average daily dietary valine intake normal mean valine intake normal valine intake Normal average daily dietary valine intake is an average daily dietary histidine intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary valine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0218431 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.234-243. low average daily dietary vitamin K intake low mean vitamin K intake low vitamin K intake Low average daily dietary vitamin K intake is an average daily dietary vitamin K intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary vitamin K for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0232327 Definition source: http://www.nml.nih.gov/medlineplus/ency/article/003480.htm blood serum albumin concentration measurement datum albumin level albumin measurement serum albumin concentration serum albumin level Blood serum albumin concentration measurement datum is a concentration measurement datum that is the output of the serum albumin concentration assay measures the concentration of the albumin in human blood. Curation status: Incomplete ONSTR:ONSTR_0263461 Definition source: ONSTR curators. blood phenylalanine-to-tyrosine concentration ratio Phe-to-Tyr Phe/Tyr blood Phe-to-Tyr ratio blood Phe/Tyr Blood phenylalanine-to-tyrosine concentration ratio is a blood amino-acid concentration ratio datum that provides the information about how many times the concentration of phenylalanine in the blood is greater than that of tyrosine. Curation status: Incomplete ONSTR:ONSTR_0265675 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.122-139. low average daily dietary alpha-linolenic acid intake low alpha-linolenic acid intake low daily alpha-linolenic acid intake low mean alpha-linolenic acid intake Low average daily dietary alpha-linolenic acid intake is an average daily dietary alpha-linolenic acid intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary alpha-linolenic acid (aLnA) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0270384 Definition source: http://www.cdc.gov/growthcharts/who_charts.htm U.S. Center for Disease Control and Prevention (CDC) recommends that health care providers use the WHO growth standards (WHO growth charts) to monitor growth for infants and children ages 0 to 2 years of age, while CDC growth charts should be used for monitoring growth of children age 2 years and older. [Source: http://www.cdc.gov/growthcharts/who_charts.htm] WHO growth chart WHO growth charts WHO growth standards WHO international growth chart World Health Organization growth chart World Health Organization growth standards World Health Organization (WHO) growth chart is a developmental growth chart based on internationally collected data set and growth standard statistical distribution released by the WHO in 2006 as a part of results of the Multicentre Growth Reference Study (MGRS), describing the growth of children ages 0 to 59 months living in environments believed by the WHO as optimal for growth of children in six countries throughout the world, including the U.S. The WHO standards were constructed using longitudinal height (length) and weight measurements data, obtained at frequent intervals and identify how children should grow when provided optimal conditions. In the U.S. WHO growth charts are available in the format of the CDC clinical growth chart, for infants birth to 24 months of age and consist of smoothed percentile curves for the 2nd, 5th, 10th, 25th, 50th, 75th, 90th, 95th, and 98th percentiles. All percentile curves are plotted on a grid scaled to international units of measurement (kg, cm), with secondary scale in British colonial units (lb, in) and contain data entry tables and spaces for patient relevant information (patient name, ID number etc.). Curation status: Incomplete ONSTR:ONSTR_0270435 Definition source: ONSTR curators. body mass measurement assay Body mass measurement assay is mass measurement assay that measures the mass quality of human body. Curation status: Incomplete ONSTR:ONSTR_0273727 Definition source: ONSTR curators. upper tolerable nutrient intake level for lactating female population age 31-to-50 years Upper tolerable nutrient intake level for lactating female population age 31-to-50 years is an upper tolerable nutrient intake level for lactating female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy lactating female population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_0286793 Definition source: ONSTR curators. upper tolerable nutrient intake level for lactating female population age 14-to-18 years Upper tolerable nutrient intake level for lactating female population age 14-to-18 years is an upper tolerable nutrient intake level for lactating female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy lactating female population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_0286903 Definition source: ONSTR curators percent upper tolerable proline intake level datum Percent upper tolerable proline intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid proline consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for proline. Curation status: Incomplete ONSTR:ONSTR_0287800 Definition source: ONSTR curators. nutritional item intake recording objective Nutritional item intake recording objective is objective specification where the goal of nutritional item intake recording is to record the type (food item), amount of taken food and the amount of a particular nutrient a human patient has taken in a specific time interval (last 24 hours, one day, two days or three days, seven days or thirty days). Curation status: Incomplete ONSTR:ONSTR_0312097 Definition source: ONSTR curators. average daily dietary mineral intake per body mass during observed time interval Average daily dietary mineral intake per body mass during observed time interval is an average daily dietary micronutrient intake per body mass during observed time interval datum denoting the average quantity of a given dietary mineral contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_0323207 Definition source: ONSTR curators. average daily total dietary water intake during observed time interval mean water intake Average daily total dietary water intake over observed time interval datum is an average daily dietary macronutrient intake during observed time interval denoting the average intake of dietary water contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days or three days). Curation status: Incomplete ONSTR:ONSTR_0323514 Definition source: ONSTR curators. percent recommended dietary arsenic allowance Percent recommended dietary arsenic allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary arsenic consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for arsenic. Curation status: Incomplete ONSTR:ONSTR_0332601 Definition source: ONSTR curators. adequate nutrient intake for children population age 4-to-8 years Adequate nutrient intake for children population age 1-to-3 years is an adequate nutrient intake for children population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy children 4 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_0335638 Definition source: ONSTR curators percent adequate carotenoid intake datum Percent adequate carotenoid intake is a percent adequate vitamin intake that provides the information about the total quantity of all carotenoids combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for (total) carotenoid. Curation status: Incomplete ONSTR:ONSTR_0337384 Definition source: ONSTR curators. third newborn dried blood spot screening process third DBS third screen Third newborn dried blood spor screening process is a repeated newborn screening process including the repeating of some of the screening tests previously performed during the second newborn screening process and is contigent on the outcome of the results of the second newborn screening. Curation status: Incomplete ONSTR:ONSTR_0339986 Definition source: Asfaw, M., Buchanan, C., Davis, R., Glassman, M., Noakes, W., O'Leary, E., Wasseff, S. (1993) Pediatric parenteral nutrition support handobook. Nutrition support service, Egleston Children's Hospital, Emory University, Atlanta, GA, pp. 6-10. Definition source: Guidelines on paediatric parenteral nutrition: 8. Vitamins. Journal of pediatric and nutrition, Vol 41, Suppl. 2, S41-S53, November 2005. Parenteral multivitamin solution is usually added to parenteral dextrose solution, or other parenteral nutrition solution, and not administered as direct undiluted injection, as it may give rise to dizziness, faintness, possible tissue irritation and other adverse reactions. parenteral multivitamin solution Parenteral multivitamin solution is a parenteral nutrition solution that contains both fat soluble vitamins (water solubilized with polysorbate 80 or other solubilizer) and water soluble vitamins, and that is usually composed of multivitamin powder formula (a dry mixture of various vitamins in various concentrations) diluted in sterile water (reconstituted). Curation status: Incomplete ONSTR:ONSTR_0342141 Definition source: ONSTR curators. average daily dietary silicon intake during observed time interval average dietary Si intake daily dietary silicon intake daily silicon intake Average daily dietary silicon intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary silicon contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_0348887 Definition source: ONSTR curators. average daily dietary threonine intake during observed time interval average daily dietary Thr intake daily Thr intake mean threonine intake Average daily threonine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid threonine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_0351035 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 6-12. normal average daily total dietary carbohydrate intake normal carbohydrate intake normal daily carbohydrate intake normal mean carbohydrate intake Normal average daily dietary carbohydrate intake is an average daily total dietary carbohydrate intake during observed time interval that has the value equal to that of the estimated average requirement (DRI-EAR) or the recommended dietary allowance (DRI-RDA) or the adequate intake (DRI-AI) for total dietary carbohydrates for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0351392 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm boys birth-to-36 months length-for-age weight-for-age percentile chart Birth to 36 months: Boys, length-for-age and weight-for-age percentiles boys length-for-age and weight-for-age percentile chart boys length-for-age and weight-for-age percentiles Boys birth-to-36 months height-for-age weight-for-age percentile chart is a height-for-age weight-for-age percentile chart that illustrates the distributions of height and weight measurement data with respect to age in a population of healthy boys 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_0352832 Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf newborn screening follow-up system process objective Newborn screening system process objective is an objective specification to ensure the prompt identification of and provide best possible treatment for the newborns with inheritable and congenital disorders. Curation status: Incomplete ONSTR:ONSTR_0353807 Definition source: ONSTR curators percent upper tolerable silicon intake level datum Percent upper tolerable silicon intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of silicon consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for silicon. Curation status: Incomplete 7.0 12.0 34.0 49.0 7.0 73.0 87.0 1.0 4.0 24.0 32.0 19.0 16.0 20.0 14.0 19.0 9.0 14.0 18.0 22.0 4.0 9.0 9.0 14.0 19.0 24.0 14.0 19.0 17.0 21.0 21.0 26.0 24.0 30.0 15.0 ONSTR:ONSTR_0366528 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] normal average daily dietary threonine intake per body mass Normal average daily dietary threonine per body mass is an average daily threonine intake per body mass during observed that has the value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary threonine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0367319 Definition source: ONSTR curators. average daily dietary arsenic intake during observed time interval average Ar intake daily arsenic intake Average daily dietary arsenic intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary arsenic contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_0371671 Definition source: ONSTR curators percent estimated average leucine requirement datum Percent estimated average leucine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid leucine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for leucine. Curation status: Incomplete ONSTR:ONSTR_0385961 Definition source: ONSTR curators. upper tolerable nutrient intake level for male population age 19-to-30 years Upper tolerable nutrient intake level for male population age 19-to-30 years is an upper tolerable nutrient intake level for male population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy male population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_0403610 Definition source: ONSTR curators. estimated average nutrient requirement for male population age 31-to-50 years Estimated average nutrient requirement for male population age 31-to-50 years is an estimated average nutrient requirement for male population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of male population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_0426948 Definition source: http://purl.org/obo/owl/GO#GO_0004505 phenylalanine-4-hyrdoxylase function PAH function Phenylalanine-4-hyrdoxylase function is a function that inheres in the enzyme phenylalanine-4-monooxygenase (PAH) and that is realized in its catalytic activity of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. Curation status: Incomplete http://purl.org/obo/owl/GO#GO_0004505 ONSTR:ONSTR_0428452 Definition source: ONSTR curators percent estimated average cysteine requirement datum Percent estimated average cysteine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid cysteine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for cysteine. Curation status: Incomplete 7.0 12.0 93.0 7.0 161.0 1.0 4.0 63.0 19.0 42.0 14.0 19.0 9.0 14.0 47.0 4.0 9.0 9.0 14.0 49.0 14.0 19.0 44.0 56.0 62.0 15.0 ONSTR:ONSTR_0440505 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] high average daily dietary leucine intake per body mass High average daily dietary leucine per body mass is an average daily leucine intake per body mass during observed that has value that is greater than that of the recommended dietary allowance (DRI-RDA) for dietary leucine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0440952 Definition source: ONSTR curators. upper tolerable nutrient intake level for population age 0-to-8 years Upper tolerable nutrient intake level for population age 0-to-8 years is an upper tolerable nutrient intake level for healthy population that that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of population 0 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_0442823 Definition source: ONSTR curators. average daily dietary vanadium intake during observed time interval average V intake daily dietary vanadium intake daily vanadium intake Average daily dietary vanadium intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary vanadium contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_0446553 Definition source: ONSTR curators. tolerable amino-acid intake datum amino-acid intake tolerance amino-acid tolerance Tolerable amino-acid intake datum is a tolerable nutrient intake datum that provides the information about quantity of a particular amino-acid that a patient can consume enterally or parenterally during the 24 hours time interval, such that the value of the concentration of the observed amino-acid in a bodily fluid (usually blood or urine) measured after the observed 24 hours falls within the therapeutic range for that particular amino-acid. Curation status: Incomplete ONSTR:ONSTR_0452049 Definition source: ONSTR curators. percent recommended dietary copper allowance Percent recommended dietary copper allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary copper consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for copper. Curation status: Incomplete ONSTR:ONSTR_0469016 Definition source: Kemp, D. F. (2002) Otoacoustic emissions, their origin in cochlear function, and use. British Medical Bulletin 2002;63: pp 223-241 Transient evoked otoaoustic emissions (TEOAEs)are highly sensitive to cochlear pathology and in a frequency-specific way. Because of their sensitivity to cochlear dysfunction, TEOAEs have found a wide-spread application in newborn screening programs. Healthy infant ears typically produce strong otoacoustic emission levels of 15 db SPL to more than 30 db SPL. [Source: Kemp, D. F. (2002) Otoacoustic emissions, their origin in cochlear function, and use. British Medical Bulletin 2002;63: pp 223-241. ] transient evoked otoacoustic emissions test TEOAE recording TEOAE test Transient evoked otoaoustic emissions test (TEAOEs test) is an otoacoustic emissions test with the objective to detect, record and measure the cochlear sound emissions generated in response to the click stimuli (usually of around 84 dB of sound pressure level (db SPL)). Curation status: Incomplete ONSTR:ONSTR_0477465 Definition source: ONSTR curators. body height at long-term follow-up visit measurement datum Body height long-term follow-up visit measurement datum is a body height measurement datum that is the result of the body height measurement assay performed during physical examination at each scheduled patient visit. Curation status: Incomplete ONSTR:ONSTR_0487622 Definition source: ONSTR curators percent estimated average iodine requirement datum Percent estimated average iodine requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of iodine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for iodine. Curation status: Incomplete ONSTR:ONSTR_0488722 Definition source: ONSTR curators percent adequate molybdenum intake datum Percent adequate molybdenum intake is a percent adequate dietary mineral intake that provides the information about the quantity molybdenum consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for molybdenum. Curation status: Incomplete ONSTR:ONSTR_0494803 Definition source: ONSTR curators. percent daily energy intake from fatty acid percent daily energy from fatty acid percent energy from fatty acid Percent daily energy intake from fatty acid is a percent daily energy intake providing the information about the quantity of energy derived from total amount of a particular fatty acid taken by a patient (enterally or parenterally) during the 24 hour time interval, and that is expressed as a percentage of the total dietary energy intake. Curation status: Incomplete ONSTR:ONSTR_0514381 Definition source: ONSTR curators. percent recommended dietary water allowance Percent recommended dietary water allowance is a percent recommended dietary macronutrient allowance that provides the information about the total quantity of dietary water consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for water. Curation status: Incomplete ONSTR:ONSTR_0534168 Definition source: ONSTR curators. average daily dietary zinc intake per body mass during observed time interval Average daily dietary zinc intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval datum denoting the average quantity of dietary zinc contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_0543092 Definition source: ONSTR curators. blood plasma ornithine concentration measurement datum plasma Orn plasma Orn level plasma Orn status plasma ornithine concentration plasma ornithine level plasma ornithine measurement plasma ornithine status Blood plasma ornithine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid ornithine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_0548398 Definition source: ONSTR curators percent upper tolerable phosphorus intake level datum Percent upper tolerable phosphorus intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of phosphorus consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for phosphorus. Curation status: Incomplete ONSTR:ONSTR_0551279 Definition source: ONSTR curators percent estimated average pantothenic acid requirement datum Percent estimated average pantothenic acid requirement is a percent estimated average vitamin requirement that provides the information about the quantity of pantothenic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for pantothenic acid. Curation status: Incomplete ONSTR:ONSTR_0551578 Definition source: ONSTR curators. adequate nutrient intake for infant population age 0-to-6 months Adequate nutrient intake for infant population age 0-to-6 months is an adequate nutrient intake for infant population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy infants 0 to 6 months of age. Curation status: Incomplete 7.0 12.0 1.0 7.0 1.52 1.0 4.0 0.87 4.0 14.0 0.76 19.0 0.66 0.73 0.71 14.0 19.0 0.88 1.05 15.0 ONSTR:ONSTR_0565893 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.144-155. low average daily total dietary protein intake per body mass Low average daily total dietary protein per body mass is an average daily total protein intake per body mass during observed that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for total dietary protein per body mass for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_0572675 Definition source: http://www.cdc.gov/growthcharts/charts.htm boys body mass index-for-age percentile clinical chart 2 to 20 years: Boys, Body mass index-for-age percentiles Boys body mass index-for-age percentile clinical chart is a body mass index-for-age percentile clinical chart that is a slight modification of the individual body mass index-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of body mass indices with respect to age in a population of healthy boys 2 to 20 years of age as well as the data entry tables and space for relevant patient information. Curation status: Incomplete ONSTR:ONSTR_0573506 Definition source: An Act concerning coverage for foods and food products for inherited metabolic diseases and supplementing P.L.1938, c.366 (C.17:48-1 et seq.), P.L.1940, c.74 (C.17:48A-1 et seq.), P.L.1985, c.236 (C.17:48E-1 et seq.), chapter 26 of Title 17B of the New Jersey Statutes, chapter 27 of Title 17B of the New Jersey Statutes, P.L.1992, c.161 (C.17B:27A-2 et seq.), P.L.1992, c.162 (C.17B:27A-17 et seq.),P.L.1973, c.337 (C.26:2J-1 et seq.) and P.L.1961, c.49 (C.52:14-17.25 et seq.). section C.17:48A-7q C.17:48A-7q "Coverage for treatment of inherited metabolic diseases by medical service corporation", retrievable at: http://www.njleg.state.nj.us/9697/bills/pl97/338_.htm modified low protein food MPLF low protein modified food low protein modified food product low protein modified food products low protein modified foods modified low protein foods Modified low protein food is a food item that is a food product specially formulated to have less than 1g of protein per serving, and is intended to be used under the direction of a physician for the dietary treatment of an inherited metabolic disease, but does not include a natural food that is naturally low in protein. Curation status: Incomplete ONSTR:ONSTR_0585383 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. high average daily dietary threonine intake high mean threonine intake high threonine intake High average daily dietary threonine intake is an average daily dietary histidine intake during observed time interval that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary threonine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0585984 Definition source: ONSTR curators percent upper tolerable alanine intake level datum Percent upper tolerable alanine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid alanine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for alanine. Curation status: Incomplete ONSTR:ONSTR_0586792 Definition source: ONSTR curators. recommended dietary allowance for children population age 1-to-3 years Recommended dietary allowance for children population age 1-to-3 years is a recommended dietary allowance for children population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy children population 1 to 3 years of age. Curation status: Incomplete ONSTR:ONSTR_0629239 Definition source: ONSTR curators. average daily dietary intake during observed time interval of phenylalanine and tyrosine combined Average daily dietary intake during observed time interval of phenylalanine and tyrosine combined is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acids phenylalanine and tyrosine combined, contained in all food items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_0630865 Definition source: ONSTR curators. blood plasma phenylalanine concentration measurement datum plasma Phe plasma Phe level plasma Phe status plasma phenylalanine concentration plasma phenylalanine level plasma phenylalanine measurement plasma phenylalanine status Blood plasma phenylalanine concentration mesasurement datum is a blood plasma amino acid concentration measurement datum that is the output of tandem mass specterometry or high performance liquid chromatography or liquid chromatography-mass spectrometry measuring the conentration of the amino acid phenylalanine in human blood plasma speciment that is obtained from blood specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_0645128 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. low average daily dietary tryptophan intake low mean tryptophan intake low tryptophan intake Low average daily dietary tryptophan intake is an average daily dietary tryptophan intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary tryptophan for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_0651839 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm height-for-age weight-for-age percentile chart heigh-for-age and weight-for-age percentile chart Height-for-age weight-for-age percentile chart is a CDC clinical growth chart that consists of modifications in format of two individual growth charts whereby height-for-age and weight-for-age charts appear on a single page as a single combined chart. Height-for-age weight-for-age chart consists of two sets of smoothed percentile curves, where the upper set of curves illustrates the distribution of height measurement data (body height measurements)with respect to age, while the lower set illustrates weight measurement data (body mass measurements) with respect to age, both in a population of healthy children of specific age group. Percentile curves are plotted against a single scaled grid where weight and height measurement units (respectively) are placed on combined the vertical scale, while age measurement units are placed on the horizontal scale of the grid. Curation status: Incomplete ONSTR:ONSTR_0656655 Definition source: ONSTR curators percent estimated average vitamin requirement datum Percent estimated average vitamin requirement is a percent estimated average micronutrient requirement that provides the information about the quantity of specific vitamin consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for the observed vitamin. Curation status: Incomplete ONSTR:ONSTR_0677523 Definition source: ONSTR curators. blood plasma glycine concentration measurement datum plasma Gly plasma Gly level plasma Gly status plasma glycine concentration plasma glycine measurement plasma glycine status Blood plasma glycine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid glycine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_0679347 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.202-210. low average daily dietary vitamin C intake low mean vitamin C intake low vitamin C intake Low average daily dietary vitamin C intake is an average daily dietary vitamin C intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary vitamin C for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0681536 Definition source: ONSTR curators. phenylalanine accumulation Phenylalanine accumulation is a pathological bodily process of increasing the quantity of amino-acid L-phenylalanine in the blood and cerebrospinal fluid above the level that is considered clinically normal due to abnormally low catalytic activity of the enzyme phenyalalnie-4-hydroxylaze. Curation status: Incomplete ONSTR:ONSTR_0682272 Definition source: ONSTR curators. body mass at research study visit measurement datum Body mass at research study visit measurement datum is body mass measurement datum that is the result of mass measurement assay of research study participant's body height performed during physical examination during the scheduled research study visit. Curation status: Incomplete ONSTR:ONSTR_0685099 Definition source: ONSTR curators. newborn screening long-term follow-up protocol LTFU protocol NBS LTFU protocol NBS-LTFU protocol Newborn screening long-term follow-up protocol is a newborn screening system protocol specifying all actions to be performed and agents involved in processes of long-term follow-up of patients diagnosed with heritable disorders. Curation status: Incomplete. ONSTR:ONSTR_0692868 Definition source: http://asha.org./public/hearing/Hearing-Screening-and-Hearing-Evaluation/ Definition source: http://purl.bioontology.org/ontology/MSH/D006309 hearing assay audition assay Hearing assay is an organismal assay performed with the objective to provide the information about human ability of sensing and transducing acoustic stimulation to the central nervous system. Curation status: Incomplete ONSTR:ONSTR_0719792 Definition source: ONSTR curators. age at newborn screening proper measurement datum Age at newborn screening measurement datum is age since birth measurement datum that is the result of measurement of time elapsed from birth of the neonate until the time when the age measurement is being done during one of the newborn screening proper processes (i.e. dried blood spot specimen creation or hearing screening or pulse oximetry screening for critical congenital heart disorders). Curation status: Incomplete ONSTR:ONSTR_0723441 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 156-166. normal average daily total dietary water intake normal daily water intake normal mean water intake normal water intake Normal average daily dietary water intake is an average daily total dietary water intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for total dietary water for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0726216 Definition source: ONSTR curators. estimated average nutrient requirement for female population age 51-to-70 years Estimated average nutrient requirement for female population age 51-to-70 years is an estimated average nutrient requirement for non-pregnant non-lactating female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of female population of 51 to 70 years of age. Curation status: Incomplete ONSTR:ONSTR_0729394 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm girls birth-to-36 months length-for-age weight-for-age percentile chart Birth to 36 months: Girls, length-for-age and weight-for-age percentiles girls length-for-age and weight-for-age percentile chart girls length-for-age and weight-for-age percentiles Girls birth-to-36 months height-for-age weight-for-age percentile chart is a height-for-age weight-for-age percentile chart that illustrates the distributions of height and weight measurement data with respect to age in a population of healthy girls 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_0736365 Definition source: ONSTR curators percent adequate thiamine intake datum Percent adequate thiamine intake is a percent adequate vitamin intake that provides the information about the quantity of thiamine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for thiamine. Curation status: Incomplete ONSTR:ONSTR_0738774 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.122-139. normal average daily dietary alpha-linolenic acid intake normal alpha-linolenic acid intake normal daily alpha-linolenic acid intake normal mean alpha-linolenic acid intake Normal average daily dietary alpha-linolenic acid intake is an average daily dietary alpha-linolenic acid intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary alpha-linolenic acid (aLnA) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0773490 Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf Second- and third-tier tests are commonly done on the original dried blood spot specimen (collected during the initial newborn screening) and are to be distinguished from the repeated newborn screening testing that involves retesting on the original specimen performed by the screening laboratory, or second screening tests that require a fresh specimen (obtained during the repeated newborn screening). [Source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf ] third-tier newborn dried blood spot screening process Third-tier dried blood spot newborn screening process is a dried blood spot newborn screening proper system process commonly performed on the dried blood spot specimen collected during the initial newborn screening for the purposes of performing additional test or tests following the previously positive positive second-tier test result. Curation status: Incomplete ONSTR:ONSTR_0793963 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.188-195. high average daily dietary vitamin B12 intake high mean vitamin B12 intake high vitamin B12 intake High average daily dietary vitamin B12 intake is an average daily dietary vitamin B12 intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary vitamin B12 for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0802429 Definition source: ONSTR curators percent adequate pantothenic acid intake datum Percent adequate pantothenic acid intake is a percent adequate vitamin intake that provides the information about the quantity of pantothenic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for pantothenic acid. Curation status: Incomplete ONSTR:ONSTR_0810120 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. low average daily dietary histidine intake low histidine intake low mean histidine intake Low average daily dietary histidine intake is an average daily dietary histidine intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary histidine for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_0812331 Definition source: ONSTR curators. Definition source: http://purl.bioontology.org/ontology/RCD/X74Uk arterial blood specimen collecting arterial blood sampling Arterial blood specimen collecting is blood specimen collecting by which a portion of arterial blood is collected from a human patient or study subject by making a small puncture in patient's artery followed by collecting a portion of leaked arterial blood in a protocol appropriate container. Curation status: Incomplete ONSTR:ONSTR_0829886 Definition source: ONSTR curators. human age Human age is organismal quality that inheres in a human being by virtue of the time elapsed in utero from conception until the birth or the period of time elapsed since the birth until the given time point of age measurement. Curation status: Incomplete ONSTR:ONSTR_0848622 Definition source: Academy of Nutrition and Dietetics (2013) International Dietetics and Nutrition Terminology (IDNT) Reference Manual. Standardized Language for the Nutrition Care Process. 4th Ed. Academy of Nutrition and Dietetics, Chicago, IL, pp. 10-11, 37-48. performing nutrition diagnosis Performing nutrition diagnosis is a performing a diagnosis that realizes the dietitian role and that consists of identifying the nutrition related problem and the etiology or contributing risk factor thereof and related signs and symptoms. Curation status: Incomplete ONSTR:ONSTR_0856506 Definition source: ONSTR curators. percent recommended dietary cholesterol allowance Percent recommended dietary cholesterol allowance is a percent recommended dietary macronutrient allowance that provides the information about the total quantity of dietary cholesterol consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for dietary cholesterol. Curation status: Incomplete ONSTR:ONSTR_0867118 Definition source: ONSTR curators. average daily dietary calcium intake per body mass during observed time interval Average daily dietary calcium intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval datum denoting the average quantity of dietary calcium contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_0870721 Definition source: ONSTR curators. average daily dietary macronutrient intake during observed time interval Average daily dietary macronutrient intake over observed time interval datum is an average daily nutrient intake during observed time interval datum denoting the average quantity of a given macronutrient contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_0874986 Definition source: http://www.cdc.gov/growthcharts/charts.htm boys body mass index-for-age percentile chart Body mass index-for-age percentiles: Boys, 2 to 20 years boys BMI-for-age percentile chart boys body mass index-for-age percentile chart boys body mass index-for-age percentiles Boys body mass index-for-age percentile chart is a body mass index-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of body mass indices with respect to age in a population of healthy boys 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_0898481 Definition source: ONSTR curators. average daily dietary asparagine intake per body mass during observed time interval Average daily asparagine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid asparagine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_0901764 Definition source: ONSTR curators. body mass at birth measurement datum Body mass at birth measurement datum is body mass measurement datum that is the result of mass measurement assay of human body performed shortly after birth. Curation status: Incomplete ONSTR:ONSTR_0923831 Definition source: ONSTR curators. average daily dietary molybdenum intake during observed time interval average dietary Mo intake daily dietary molybdenum intake daily molybdenum intake mean molybdenum intake Average daily dietary molybdenum intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary molybdenum contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_0937984 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.274-279. low average daily dietary riboflavin intake low mean riboflavine intake low riboflavine intake Low average daily dietary riboflavin intake is an average daily dietary riboflavin intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary riboflavin for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0941122 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. high average daily dietary leucine intake high leucine intake high mean leucine intake High average daily dietary leucine intake is an average daily dietary histidine intake during observed time interval that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary leucine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete 7.0 12.0 39.0 58.0 7.0 87.0 93.0 1.0 4.0 28.0 37.0 19.0 19.0 24.0 14.0 19.0 9.0 14.0 22.0 27.0 4.0 9.0 9.0 14.0 23.0 28.0 14.0 19.0 20.0 24.0 25.0 31.0 28.0 35.0 15.0 ONSTR:ONSTR_0941680 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. normal average daily dietary valine intake per body mass Normal average daily dietary valine per body mass is an average daily valine intake per body mass during observed that has the value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) for dietary valine patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0942164 Definition source: ONSTR curators. upper tolerable level percentage %UL Upper tolerable level percentage is a dietary reference intake percentage unit (dimensionless unit) which denotes the quantity of a dietary nutrient that may be (or has been) consumed by a human as a percentage of the upper tolerable intake level for that specific nutrient. Curation status: Incomplete ONSTR:ONSTR_0963392 Definition source: http://en.wikipedia.org/wiki/Range_(statistics) Note: Class name 'range datum' does not refer to the 'range statistic' which refers to the difference between the largest and the smallest value of a particular statistical data set. range datum Range datum is a data item that provides the information about the set of values limited by the smallest and largest value a particular (observed) measurement datum takes in observed research, clinical or medical context/situation. Curation status: Incomplete Therapeutic range for blood phenylalanine concentration is XXX to XXX μM ONSTR:ONSTR_0966715 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.188-195. low average daily dietary vitamin B12 intake low mean vitamin B12 intake low vitamin B12 intake Low average daily dietary vitamin B12 intake is an average daily dietary vitamin B12 intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary vitamin B12 for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0966733 Definition source: ONSTR curators. adequate nutrient intake male population age 9-to-13 years Adequate nutrient intake for male population age 9-to-13 years is an adequate nutrient intake for male population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy male population 9 to 13 years of age. Curation status: Incomplete ONSTR:ONSTR_0969453 Definition source: ONSTR curators. percent recommended dietary silicon allowance Percent recommended dietary silicon allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary silicon consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for silicon. Curation status: Incomplete ONSTR:ONSTR_0974359 Definition source: http://medical-dictionary.thefreedictionary.com/therapeutic+range blood chemical concentration therapeutic range datum Blood chemical concentration therapeutic range datum is a therapeutic range datum providing the information about the set of values (limited by the minimal and maximal values) of the concentration of particular chemical in the blood, such that the concentration values falling within this range do not produce or produce minimal toxic effects to most of the members of the observed population. Curation status: Incomplete ONSTR:ONSTR_0981568 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.122-139. low average daily dietary linoleic acid intake low daily linoleic acid intake low linoleic acid intake low mean linoleic acid intake Low average daily dietary linoleic acid intake is an average daily dietary linoleic acid intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary linoleic acid (LA) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_0983341 Definition source: ONSTR curators. venous blood specimen Venous blood specimen is a blood specimen that is derived from portion of human venous blood and is specified output of venous blood specimen collecting. Curation status: Incomplete ONSTR:ONSTR_0992681 Definition source: ONSTR curators. age at newborn pulse oximetry test measurement datum Age at newborn pulse oximetry test measurement datum is an age at newborn screening measurement datum that is the result of measurement of time elapsed from birth of the neonate until the time when on of the pulse oximetry test has been done on a newborn. Curation status: Incomplete ONSTR:ONSTR_0999466 Definition source: ONSTR curators. nutrient intake summary report Nutrient intake summary report is an information content entity that contains the information about the energy intake value and the average quantities of all nutrients contained in food items consumed by a patient in a specific time interval relevant for dietary analysis. Curation status: Incomplete ONSTR:ONSTR_1012174 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.380-384. high average daily dietary selenium intake high mean selenium intake high selenium intake High average daily dietary selenium intake is an average daily dietary selenium intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary selenium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1013653 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp. 304-310. normal average daily dietary copper intake normal copper intake normal mean copper intake Normal average daily dietary copper intake is an average daily dietary copper intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary copper for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1017357 Definition source: ONSTR curators consumed dietary supplement datum Consumed dietary supplement datum is a dietary supplement datum providing the information about the kinds and quantities of dietary supplements consumed (ingested) by a human patient during the time interval relevant for the dietary analysis. Curation status: Incomplete ONSTR:ONSTR_1034362 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 286-295. high average daily dietary calcium intake high calcium intake high mean calcium intake High average daily dietary calcium intake is an average daily dietary calcium intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary calcium for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1036144 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.122-139. high average daily dietary linoleic acid intake high daily linoleic acid intake high linoleic acid intake high mean linoleic acid intake High average daily dietary linoleic acid intake is an average daily dietary linoleic acid intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary linoleic acid (LA) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1045375 Definition source: ONSTR curators. average daily dietary sulfate intake during observed time interval daily dietary sufate intake daily sufate intake Average daily dietary sulfate intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of all dietary sufates combined and contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete 7.0 12.0 86.0 7.0 107.0 1.0 4.0 58.0 19.0 38.0 14.0 19.0 9.0 14.0 43.0 4.0 9.0 9.0 14.0 46.0 14.0 19.0 40.0 51.0 52.0 15.0 ONSTR:ONSTR_1057796 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] high average daily dietary lysine intake per body mass High average daily dietary lysine per body mass is an average daily lysine intake per body mass during observed that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary lysine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1058537 Definition source: ONSTR curators percent estimated average riboflavin requirement datum Percent estimated average riboflavin requirement is a percent estimated average vitamin requirement that provides the information about the quantity of riboflavin consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for riboflavin. Curation status: Incomplete ONSTR:ONSTR_1060087 Definition source: ONSTR curators. percent daily energy intake from linoleic acid percent daily energy from linoleic acid percent energy from linoleic acid Percent daily energy intake from linoleic acid is a percent daily dietary energy intake providing the information about the quantity of energy derived from total amount of linoleic acid taken by a patient (enterally or parenterally) during the 24 hour time interval, and that is expressed as a percentage of the total dietary energy intake. Curation status: Incomplete ONSTR:ONSTR_1061345 Definition source: ONSTR curators percent adequate linoleic acid intake datum Percent adequate linoleic acid intake is a percent adequate fatty acid intake that provides the information about the quantity of linoleic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for linoleic acid. Curation status: Incomplete ONSTR:ONSTR_1062304 Definition source: http://medical-dictionary.thefreedictionary.com/parenteral+nutrition Intravenous administration of the nutrient solution is often accomplished via a central venous catheter, usually inserted in the superior vena cava or subclavian vein, or through the periferal vein. [Source: http://medical-dictionary.thefreedictionary.com/parenteral+nutrition ] total parenteral nutrient administration TPN hyperalimentation total pareneteral hyperalimentation total pareneteral nutrition Total parenteral nutrition is a parenteral administration where parenteral nutrition solution is introduced into the human patient intavenously. Curation status: Incomplete ONSTR:ONSTR_1070048 Definition source: ONSTR curators percent adequate water intake datum Percent adequate water intake is a percent adequate macronutrient intake that provides the information about the total quantity of water consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for (total) water. Curation status: Incomplete ONSTR:ONSTR_1078667 Definition source: ONSTR curators. average daily total dietary carotenoid intake during observed time interval Average daily total dietary carotenoid intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of all carotenoids contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_1078710 Definition source: Kemp, D. F. (2002) Otoacoustic emissions, their origin in cochlear function, and use. British Medical Bulletin 2002;63: pp 223-241 Definition source: http://asha.org./public/hearing/Otoacoustic-Emissions Even though the intensity of the observed OAE response is a primary factor of in OAE detectability, it is the presence of a detectable OAE response to a particular stimulus that is clinically important and not its strength. [Source: Kemp, D. F. (2002) Otoacoustic emissions, their origin in cochlear function, and use. British Medical Bulletin 2002;63: pp 223-241.] Otoacoustic emissions (OAEs) are recorded via an ear canal probe (containing both the miniature sound source and the microphone transducer) which is inserted deeply into the ear canal) after an auditory stimulus presentation. Unlike other audiometric tests,in the case of OAE recording, it is not necessary for the stimulus to be near to threshold levels to detect departures from normal function. Middle ear status (middle ear fluid or blockage) affects the OAEs and can prevent their detection. OAE signals are very sensitive to minos conductive losses caused by middle ear fluid and ear canal debris in neonates, so that sometimes, in first few hours after birth, an auditory brain-stem response (ARB) can be recorded and OAE cannot. [Source: Kemp, D. F. (2002) Otoacoustic emissions, their origin in cochlear function, and use. British Medical Bulletin 2002;63: pp 223-241.] otoacoustic emissions test OAE recording OAE test Otoacoustic emissions test is a hearing assay with the objective to detect, record and measure the otoacoustic emissions (OAEs), the sound waves that are produced by the motion of the outer cochlea hair cells responding to the auditory stimulation (as a by-product of a cochlear mechanism known as 'cochlear amplification') and that are transmitted backwards through the middle ear and received by the tympanum (ear drum). Curation status: Incomplete ONSTR:ONSTR_1089604 Definition source: ONSTR curators. upper tolerable nutrient intake level for male population Upper tolerable nutrient intake level for male population is an upper tolerable nutrient intake level for population age 9 years and older that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy male population. Curation status: Incomplete ONSTR:ONSTR_1109901 Definition source: ONSTR curators. blood chemical concentration ratio datum Blood chemical concentration ratio datum is a data item that provides the information about the ratio of concentrations of clinically relevant chemicals (e.g. nutrients, metabolites, pharmacological agents) in the blood. Curation status: Incomplete ONSTR:ONSTR_1113327 Definition source: ONSTR curators. human state with respect to pregnancy and lactation categorical datum label Human state with respect to pregnancy and lactation categorical datum label is a categorical label denoting the category of the human state datum with respect to pregnancy and lactation. Curation status: Incomplete ONSTR:ONSTR_1115755 Definition source: ONSTR curators. cerebrospinal fluid phenylalanine concentration measurement datum CSF Phe CSF Phe concentration CSF Phe level CSF phenylalanine concentration CSF phenylalanine level CSF phenylalanine measurement CSF phenylalanine status Cerebrospinal fluid phenylalanine concentration mesasurement datum is a concentration measurement datum that is the output of the cerebrospinal fluid phenylalanine concentration measurement assay that measures the concentration of the amino-acid phenylalanine in human cerebrospinal fluid. Curation status: Incomplete ONSTR:ONSTR_1119226 Definition source: ONSTR curators. percent recommended dietary vitamin A allowance Percent recommended dietary vitamin A allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary vitamin A consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for vitamin A. Curation status: Incomplete ONSTR:ONSTR_1119426 Definition source: ONSTR curators. average daily dietary phenylalanine intake per body mass during observed time interval Average daily phenylalanine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of a amino-acid phenylalanine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_1124010 Definition source: ONSTR curators dietary supplement datum Dietary supplement datum is a nutritional item datum that provides the information about the kinds and quantities of dietary supplements prescribed to or consumed by a human patient. Curation status: Incomplete ONSTR:ONSTR_1126583 Definition source: ONSTR curators percent estimated average isoleucine requirement datum Percent estimated average isoleucine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid isoleucine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for isoleucine. Curation status: Incomplete ONSTR:ONSTR_1155298 Definition source: ONSTR curators. blood specimen creation measurement datum Blood specimen creation measurement datum is a specimen creation measurement datum that provides the information about the time the blood specimen have been created. Curation status: Incomplete ONSTR:ONSTR_1162650 Definition source: ONSTR curators. blood selenium concentration measurement datum blood selenium level blood selenium measurement serum selenium level serum selenium measurement Blood selenium concentration measurement datum is a blood chemical concentration measurement datum that provides the information about the concentration of selenium in the blood plasma or serum specimen. Curation status: Incomplete ONSTR:ONSTR_1164002 Definition source: http://medical-dictionary.thefreedictionary.com/therapeutic+range therapeutic range datum Therapeutic range datum is a range datum that provides the information about the concentration range of a particular chemical (e.g. medication, therapeutic agent, nutrient or metabolite) in an observed bodily fluid such that the concentration values falling within this range do not produce or produce minimal toxic effects to most of the members of the observed population. Curation status: Incomplete ONSTR:ONSTR_1164140 Definition source: ONSTR curators. average daily dietary energy intake during observed time interval datum Average daily dietary energy intake during observed time interval datum is a dietary energy intake datum denoting the average number of kilocalories derived from all nutritional items ingested by a human patient during the time interval observed by a dietitian (one days, two days or three days). Curation status: Incomplete ONSTR:ONSTR_1168565 Definition source: ONSTR curators percent adequate iodine intake datum Percent adequate iodine intake is a percent adequate dietary mineral intake that provides the information about the quantity iodine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for iodine. Curation status: Incomplete ONSTR:ONSTR_1177320 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 286-295. low average daily dietary calcium intake low calcium intake low mean calcium intake Low average daily dietary calcium intake is an average daily dietary calcium intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary calcium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1179053 Definition source: ONSTR curators. recommended dietary allowance for pregnant female population age 19-to-30 years Recommended dietary allowance for pregnant female population age 19-to-30 years is a recommended dietary allowance for pregnant female population that denotes the the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy pregnant female population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_1187661 Definition source: ONSTR curators. average daily dietary lysine intake per body mass during observed time interval Average daily lysine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid lysine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_1188589 Definition source: ONSTR curators. In terms of the sequentiality of newborn screening system processes, treatment initiation process usually marks the onset of the long-term follow-up of patient diagnosed with and inherited metabolic disease. Since some conditions can be life threatening within a few days after birth (e.g., organic acidurias, galactosemia, maple sirup urine disease), the therapeutic treatment is been initiated as soon a positive result for such diseases has been reported through newborn dried blood spot screening. [Source: Recommended uniform Screening Panel of the Secretary's Advisory Committee on Heritable Disorders in Newborns and Children. ] treatment initiation Treatment initiation is a planned process that includes the initial prescription and/or administartion of nutritional and/or medical therapy to a patient diagnosed with one of diseases detected through newborn dried blood spot screening, and that commonly marks the onset of the post newborn dried blood spot screening long-term follow-up (NDBS-LTFU). Curation status: Incomplete ONSTR:ONSTR_1191575 Definition source: ONSTR curators. upper tolerable nutrient intake level for male population age 14-to-18 years Upper tolerable nutrient intake level for male population age 14-to-18 years is an upper tolerable nutrient intake level for male population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy male population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_1196394 Definition source: ONSTR curators percent adequate arsenic intake datum Percent adequate arsenic intake is a percent adequate dietary mineral intake that provides the information about the quantity arsenic consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for arsenic. Curation status: Incomplete ONSTR:ONSTR_1199665 Definition source: ONSTR curators. estimated average nutrient requirement for children population Estimated average nutrient requirement for children population is an estimated average nutrient requirement for population age 0-to-8 years that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of children population 1 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_1207407 Definition source: ONSTR curators. average daily dietary fluoride intake during observed time interval daily dietary fluoride intake mean fluoride intake Average daily dietary fluoride intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of all dietary fluorides combined and contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_1213123 Definition source: ONSTR curators percent upper tolerable thiamine intake level datum Percent upper tolerable thiamine intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of thiamine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for thiamine. Curation status: Incomplete ONSTR:ONSTR_1228586 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.274-279. high average daily dietary riboflavin intake high mean riboflavine intake high riboflavine intake High average daily dietary riboflavin intake is an average daily dietary riboflavin intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1232612 Definition source: ONSTR curators percent estimated average asparagine requirement datum Percent estimated average asparagine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid asparagine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for asparagine. Curation status: Incomplete ONSTR:ONSTR_1252223 Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.62-64. By implication, mutated allele carrier PAH genotype is a heterozygous genotype. mutated allele carrier phenylalanine hydroxylase genotype mutated allele carrier phenylalanine hydroxylase genotype A PAH genotype that includes two alleles each coding for enzyme phenylalanine hydroxylase monomer (PAH monomer), out of which one is a normal (non-mutated, wild type) PAH monomer allele and the other is mutated (mutant) PAH monomer allele. Curation status: Incomplete ONSTR:ONSTR_1267261 Definition source: ONSTR curators. newborn dried blood spot screening test result analysis Newborn dried blood spot screening test result analysis is a data transformation that is performed by biochemical geneticist or a team of experts (including biochemical geneticist, metabolic dietitian and newborn screening program coordinator) and that has the output newborn dried blood spot screening test finding. Curation status: Incomplete ONSTR:ONSTR_1272933 Definition source: Scriver, C. R., Sly, W. S., Childs, B., Baudet, A. L., Valle, D., Kinzler, K. W., Vogelstein, B. (2000) The metabolic and molecular bases of inherited metabolic disease, 8th Ed. McGraw-Hill Professional. Need better def source. classic phenylketonuria classic PKU severe PKU Classic phenylketonuria is a hyperphenylaninemia that is caused by characterized by blood phenyalalnine concentration greater than 1200 μmol/L (20 mg/dL). Curation status: Incomplete ONSTR:ONSTR_1273733 Definition source: ONSTR curators. head size Head size is human body quality that inheres in human head by virtue of the amount of 3-dimensional space occupied by the head. Curation status: Incomplete ONSTR:ONSTR_1277105 Definition source: ONSTR curators. percent recommended dietary phenylalanine allowance Percent recommended dietary phenylalanine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary phenylalanine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid phenylalanine. Curation status: Incomplete ONSTR:ONSTR_1278470 Definition source: ONSTR curators Some parenteral multivitamin solutions need to be reconstituted (diluted in sterile water) before administration. pediatric parenteral multivitamin solution Pediatric parenteral multivitamin solution is a parenteral multivitamin solution formulated for infants and children younger than 11 years of age, and specifically for incorporation into intravenous infusions or other kinds of parenteral solutions (e.g. parenteral three-in-one solution). Curation status: Incomplete pediatric MVI-12 ONSTR:ONSTR_1280377 Definition source: ONSTR curators. adequate nutrient intake for lactating female population Adequate nutrient intake for lactating female population is an adequate nutrient intake for female population that denotes the average daily intake of a nutrient based on the observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy lactating female population. Curation status: Incomplete ONSTR:ONSTR_1282628 Definition source: ONSTR curators. vitamin specific measurement unit Vitamin specific unit is a derived unit that denotes the quantity of a particular vitamin, or vitamin precursors (provitamins) expressed in units of the International System of Measurement Units (SI), or expressed in the international units (IU). Curation status: Incomplete ONSTR:ONSTR_1286193 Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl Definition source: http://purl.bioontology.org/ontology/NCIM/C0016452 food item food foods foodstuff Food item is a nutritional item that is of either plant, animal or artificial origin (industrially manufactured) and that containins nutrients and may contain other substances (artficial colors, binders, flavors etc.) that when ingested by an organism (for purposes of nourishment or pleasure) serves to produce energy, build body tissues, stimulate growth or maintain homeostasis. Curation status: Incomplete ONSTR:ONSTR_1298692 Definition source: http://www.peds.umn.edu/iac/topics/headgrowth/home.html head circumference measurement assay head circumference measurment Head circumference measurement assay is a length measurement assay that determines the circumference of human head measured at its widest point (i.e the largest possible circumference). Measurement is usually performed by using a flexible tape measure, commonly starting from the point that is approximately 1.5 cm above (roughly 1/2 inch) the eyebrows, moving over the point slightly above left (or right ear), then over the point approximately 1.5 cm (roughly 1/2 inch) above the occipital notch, and back to the starting point on the forehead. Curation status: Incomplete ONSTR:ONSTR_1317968 Definition source: ONSTR curators. average daily dietary pantothenic acid intake per body mass during observed time interval Average daily dietary pantothenic acid intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of pantothenic acid contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_1319796 Definition source: ONSTR curators. whole blood tyrosine concentration measurement datum blood Tyr concentration blood Tyr level blood Tyr status blood tyrosine concentration blood tyrosine level blood tyrosine measurement blood tyrosine status Whole blood tyrosine concentration measurement datum is a whole blood amino-acid concentration measurement datum that provides the information about the quantity of amino-acid tyrosine in the human blood specimen (or blood eluate derived from the dried blood spot specimen) that has been collected from patient at least 2.5 or 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_1326752 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.224-233. normal average daily dietary vitamin D intake normal mean vitamin D intake normal vitamin D intake Normal average daily dietary vitamin D intake is an average daily dietary vitamin D intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary vitamin D for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1328060 Definition source: Hovasi Cox, J., Melbardis, I. M. (2005) Parenteral nutrition. In Handbook of pediatric nutrition, 3rd Ed. Jones and Bartlett publishers Inc. pp. 525-557. Definition source: O'Leary, E.,Wasseff, S. (1993) Pediatric parenteral nutrition support handobook. Nutrition support service, Egleston Children's Hospital, Emory University, Atlanta, GA, pp. 6-10. parenteral dextrose solution Parenteral dextrose solution is a parenteral nutrition solution that is a solution of monohydrous dextrose (glucose monohydrate) diluted in sterile water. Curation status: Incomplete ONSTR:ONSTR_1331876 Definition source: ONSTR curators. Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf There are specific circumstances (e.g., unsatisfactory specimens, acutely ill newborns in the NICU) under which repeat screening is commonly required. Because of the possibility of biologic false-positives, 29 States recommend/require a second specimen if tested prior to 24 hours of age and 7 States require a second specimen if the newborn is tested before 48 hours of age. False-positives for congenital hypothyroidism and congenital adrenal hyperplasia are common in premature infants but can be dealt with through retesting when the infants are a few days older and their endocrine systems are more mature. [Source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf ] second dried blood spot newborn screening process second DBS second screen Second dried blood spot newborn screening process is a repeated newborn screening process including the repeating of some of the screening processes previously performed during the initial newborn screening process (e.g. dried blood spot specimen creation, hearing screening). Curation status: Incomplete ONSTR:ONSTR_1357690 Definition source: ONSTR curators. percent recommended dietary tyrosine allowance Percent recommended dietary tyrosine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary tyrosine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid tyrosine. Curation status: Incomplete ONSTR:ONSTR_1360205 Definition source: Hinman, A.R., Mann, M.Y., Singh, R.H. (2009) Newborn dried bloodspot screening: mapping the clinical and public health components and activities. Genetics in Medicine, Vol.11, No. 6, June 2009. newborn screening system post dried blood spot screening short-term follow-up process NDBS short-term follow-up NDBS-STFU newborn dried blood spot screening short-term follow-up Newborn screening system post dried blood spot screening short-term follow-up process is a newborn screening system short-term follow-up process that includes medical practices designed to establish diagnosis or detect falls positive screen of a particular disease indicated by the positive newborn dried blood spot screening finding. Curation status: Incomplete ONSTR:ONSTR_1363067 Definition source: ONSTR curators. average daily dietary mineral intake during observed time interval Average daily dietary mineral intake during observed time interval is an average daily dietary micronutrient intake during observed time interval denoting the average quantity of relevant dietary minerals contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_1373812 Definition source: ONSTR curators. upper tolerable nutrient intake level for male population age 31-to-50 years Upper tolerable nutrient intake level for male population age 31-to-50 years is an upper tolerable nutrient intake level for male population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy male population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_1376910 Definition source: ONSTR curators percent upper tolerable iron intake level datum Percent upper tolerable iron intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of iron consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for iron. Curation status: Incomplete ONSTR:ONSTR_1377652 Definition source: ONSTR curators. upper tolerable nutrient intake level for female population age 9-to-13 years Upper tolerable nutrient intake level for female population age 9-to-13 years is an upper tolerable nutrient intake level for non-pregnant non-lactating female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy female population 9 to 13 years of age. Curation status: Incomplete ONSTR:ONSTR_1380321 Definition source: ONSTR curators. average daily dietary glycine intake during observed time interval average daily dietary Gly intake daily Gly intake Average daily glycine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid glycine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_1385096 Definition source: ONSTR curators. recommended dietary allowance for infant population age 7-to-12 months Recommended dietary allowance for infant population age 0-to-6 months is a recommended dietary allowance for infant population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy infant population 7 to 12 months of age. Curation status: Incomplete ONSTR:ONSTR_1390627 Definition source: ONSTR curators percent adequate dietary mineral intake datum Percent adequate dietary mineral intake is a percent adequate micronutrient intake that provides the information about the quantity of specific dietary mineral consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for the observed dietary mineral. Curation status: Incomplete ONSTR:ONSTR_1406917 Definition source: ONSTR curators percent estimated average lysine requirement datum Percent estimated average lysine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid lysine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for lysine. Curation status: Incomplete ONSTR:ONSTR_1407586 Definition source: ONSTR curators percent adequate calcium intake datum Percent adequate calcium intake is a percent adequate dietary mineral intake that provides the information about the quantity calcium consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for calcium. Curation status: Incomplete ONSTR:ONSTR_1409233 Definition source: Charney, P., Malone, A. Eds. (2004) ADA pocket guide to nutrition assessment. American Dietetic Association, pp. 33-39. one day nutritional item intake record 1-d food diary 1-d record 1-day food diary 1-day intake record 1-day record one day food intake record usual day food intake record usual day intake One day nutritional item intake record is a nutritional item intake record completed by a patient, patient's parent or caretaker or dietitian, and that contains the information about the types and quantites of consumed food items, nutritional supplements, medical foods and food amino-acid excahnges the patient has consumed in one day time interval (24 hours) prior to the follow-up visit. Curation status: Incomplete ONSTR:ONSTR_1423872 Definition source: ONSTR curators percent upper tolerable water intake level datum Percent upper tolerable water intake level is a percent upper tolerable macronutrient intake level that provides the information about the total quantity of water consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for water. Curation status: Incomplete ONSTR:ONSTR_1427222 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm 2-to-20 years stature-for-age weight-for-age percentile chart children and adolescent stature-for-age and weight-for-age percentile chart stature-for-age and weight-for-age percentile chart 2-to-20 years stature-for-age weight-for-age percentile chart is a height-for-age weight-for-age percentile chart that illustrates the distributions of height and weight measurement data with respect to age in a population of healthy children and adolescents 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_1431266 Definition source: ONSTR curators. nutritional item quantity datum Nutritional item quantity datum is a scalar measurement datum that provides the information about the quantity of a given nutritional item (consumed or prescribed). Curation status: Incomplete ONSTR:ONSTR_1445519 Definition source: ONSTR curators. phenylalanine concentration finding Phenylalanine conentration finding is a laboratory finding that is the interpretation of measurement values of the concentration of amino acid phenylalanine in the human blood specimen (including blood plasma specimen and dried blood spot eluate) or in the human crerebrospinal fluid specimen. Curation status: Incomplete ONSTR:ONSTR_1454514 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.280-285. high average daily dietary thiamine intake high mean thiamine intake high thiamine intake High average daily dietary thiamine intake is an average daily dietary thiamine intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary thiamine for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1457519 Definition source: ONSTR curators. head circumference at birth measurement datum Head circumference at birth measurement datum is a head circumference measurement datum that is the result of the head circumference measurement assay performed shortly after birth. Curation status: Incomplete ONSTR:ONSTR_1474441 Definition source: ONSTR curators. nutritional item datum Nutritional item datum is a data item that provides the information about the kinds, quantities and nutrient content of nutritional items have been prescribed to be consumed during the course of treatment or have been consumed by a human patient during the time interval relevant for dietary analysis. Curation status: Incomplete ONSTR:ONSTR_1484856 Definition source: ONSTR curators percent adequate asparagine intake datum Percent adequate asparagine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid asparagine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for asparagine. Curation status: Incomplete ONSTR:ONSTR_1496685 Definition source: ONSTR curators percent adequate glutamine intake datum Percent adequate glutamine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid glutamine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for glutamine. Curation status: Incomplete ONSTR:ONSTR_1507712 Definition source: ONSTR curators percent estimated average alpha-linolenic acid requirement datum Percent estimated average alpha-linolenic acid requirement is a percent estimated average fatty acid requirement that provides the information about the quantity of alpha-linolenic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for alpha-linolenic acid. Curation status: Incomplete ONSTR:ONSTR_1508315 Definition source: ONSTR curators. estimated average nutrient requirement for lactating female population age 14-to-18 years Estimated average nutrient requirement for lactating female population age 14-to-18 years is an estimated average nutrient requirement for lactating female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of population of lactating females 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_1509758 Definition source: Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.62. phenylalanine hydroxylase genotype PAH genotype PAH monomer genotype phenylalanine hydroxylase monomer genotype A genotype that includes two alleles (variants of a gene) coding for enzyme phenylalanine hydroxylase monomer (PAH monomer), having gene map locus 12q22-q24.2. Curation status: Incomplete ONSTR:ONSTR_1514961 Definition source: ONSTR curators percent upper tolerable vitamin B6 intake level datum Percent upper tolerable vitamin B6 intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of vitamin B6 consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for vitamin B6. Curation status: Incomplete ONSTR:ONSTR_1548265 Definition source: ONSTR curators. recommended dietary allowance for children population Recommended dietary allowance for children population is a recommended dietary allowance for population age 0-to-8 years that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy children population 1 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_1552413 Definition source: http://medical-dictionary.thefreedictionary.com/parenteral+nutrition Parnteral administration (and similarly, enteral administration) is, by implication, applicable only to the organisms that anatomically have the alimentary canal (and/or some form of gastrointestinal tract). The route of administration, constant rate of flow required, and potential patient sensitivity to the elements administered, all contribute to the potential complications of parenteral nutrition. [Source: http://medical-dictionary.thefreedictionary.com/parenteral+nutrition ] parenteral administration pareneteral route of administration parenteral route Parenteral administration is administering substance in vivo where material entity (e.g. parenteral nutrition solution, Ringer's soluton, medication in fluid phase) is introduced into the organism intravenously, subcutanously, intramuscularly, intradermally or intrasternally. Curation status: Incomplete ONSTR:ONSTR_1560326 Definition source: ONSTR curators. percent recommended dietary alpha-linolenic acid allowance Percent recommended dietary alpha-linolenic acid allowance is a percent recommended dietary fatty acid allowance that provides the information about the quantity of dietary alpha-linolenic acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for alpha-linolenic acid. Curation status: Incomplete ONSTR:ONSTR_1565174 Definition source: ONSTR curators percent estimated average potassium requirement datum Percent estimated average potassium requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of potassium consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for potassium. Curation status: Incomplete ONSTR:ONSTR_1568766 Definition source: ONSTR curators. recommended dietary allowance for population age 9 years and older Recommended dietary allowance for population age 9 years and older is a recommended dietary allowance datum that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy human population age 9 years and older. Curation status: Incomplete ONSTR:ONSTR_1574904 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 111-121. low average daily total dietary fiber intake low daily fiber intake low fiber intake low mean fiber intake Low average daily total dietary fiber intake is an average daily total dietary fiber intake during observed time interval that has value less than that of the adequate intake (DRI-AI) for total dietary fiber for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1575035 Definition source: ONSTR curators. average daily dietary iodine intake during observed time interval average dietary I intake daily dietary iodine intake daily iodine intake mean iodine intake Average daily dietary iodine intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary iodine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_1576493 Definition source: http://www.cdc.gov/growthcharts/who_charts.htm girls birth-to-24 months head circumference-for-age weight-for-length WHO growth chart Birth to 24 months: Girls, Head circumference-for-age and weight-for-length percentiles Girls birth-to-24 months head circumference-for-age weight-for-length WHO growth chart is a birth-to-24 months head circumference-for-age weight-for-length WHO growth chart that illustrates the distribution of head circumference measurements with respect to age, and weight (body mass) measurements with respect to body height (length) measurements in a population of healthy girls 0 to 24 months of age. Curation status: Incomplete ONSTR:ONSTR_1581489 Definition source: MedlinePlus Medical Encyclopedia, http://www.nlm.nih.gov/medlineplus/ency/article/003428.htm Description of actual procedures of lumbar puncture, cisternal puncture and ventricular puncture is out of scope of ONSTR. cerebrospinal fluid specimen collecting CSF specimen collecting Cerebrospinal fluid specimen collecting is collecting specimen from an organism with the objective of obtaining a specimen of cerebrospinal fluid from a human patient. Collecting of cerebrospinal fluid is most commonly obtained by the procedure of lumbar puncture (i.e. spinal tap), while rarely used methods include cisternal puncture and ventricular puncture. Curation status: Incomplete ONSTR:ONSTR_1583962 Definition source: ONSTR curators. average daily dietary calcium intake during observed time interval average Ca intake daily calcium intake mean calcium intake Average daily dietary calcium intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary calcium contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_1587001 Definition source: ONSTR curators. percent recommended dietary micronutrient allowance Percent recommended dietary micronutrient allowance is a percent recommended dietary nutrient allowance datum that provides the information about the quantity of particular dietary nutrient consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percent of the recommended dietary allowance for the observed dietary nutrient. Curation status: Incomplete ONSTR:ONSTR_1590917 Definition source: ONSTR curators. recommended dietary allowance for children population age 4-to-8 years Recommended dietary allowance for children population age 4-to-8 years is a recommended dietary allowance for children population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy children population 4 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_1597525 Definition source: ONSTR curators percent estimated average boron requirement datum Percent estimated average boron requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of boron consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for boron. Curation status: Incomplete ONSTR:ONSTR_1600296 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.356-361. high average daily dietary molybdenum intake high mean molybdenum intake high molybdenum intake High average daily dietary molybdenum intake is an average daily dietary molybdenum intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary molybdenum for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1610185 Definition source: ONSTR curators. upper tolerable nutrient intake level for population with inherited metabolic disease IMD-UL UL for inherited metabolic disease population Upper tolerable nutrient intake level for population with inherited metabolic disease is an upper tolerable nutrient intake level datum that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of a given population with inherited metabolic disease. Curation status: Incomplete ONSTR:ONSTR_1614275 Definition source: Academy of Nutrition and Dietetics (2013) International Dietetics and Nutrition Terminology (IDNT) Reference Manual. Standardized Language for the Nutrition Care Process. 4th Ed. Academy of Nutrition and Dietetics, Chicago, IL, pp. 51-61. nutrition intervention Nutrition intervention is a health care process that realizes the dietitian role and that consists of 1) planning (prioritizing the nutrition diagnoses, conferring with patient and/or patient's family, reviewing practice guidelines and policies and setting goals and defining the specific nutrition intervention strategy) and 2) implementation (carrying on and communicating plan of care, continuing data collection, revising the nutrition intervention strategy). Curation status: Incomplete ONSTR:ONSTR_1653996 Definition source: ONSTR curators. average daily dietary micronutrient intake per body mass during observed time interval Average daily dietary micronutrient intake per body mass during observed time interval is an average daily dietary nutrient intake per body mass during observed time interval information denoting the average quantity of a given micronutrient contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_1660800 Definition source: ONSTR curators percent estimated average choline requirement datum Percent estimated average choline requirement is a percent estimated average vitamin requirement that provides the information about the quantity of choline consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for choline. Curation status: Incomplete ONSTR:ONSTR_1662030 Definition source: ONSTR curators. average daily dietary glutamic acid intake per body mass during observed time interval Average glutamic acid intake per body mass during observed time interval is an average amino-acid intake per body mass during observed time interval information denoting the average quantity of glutamic acid contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_1669719 Definition source: ONSTR curators percent estimated average arachidonic acid requirement datum Percent estimated average arachidonic acid requirement is a percent estimated average fatty acid requirement that provides the information about the quantity of arachidonic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for arachidonic acid. Curation status: Incomplete ONSTR:ONSTR_1669993 Definition source: ONSTR curators. average daily dietary threonine intake per body mass during observed time interval Average daily threonine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid threonine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_1690491 Definition source: ONSTR curators. percent recommended dietary methionine allowance Percent recommended dietary methionine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary methionine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid methionine. Curation status: Incomplete 7.0 12.0 22.0 7.0 28.0 1.0 4.0 16.0 19.0 11.0 14.0 19.0 9.0 14.0 12.0 4.0 9.0 9.0 14.0 13.0 15.0 15.0 ONSTR:ONSTR_1691285 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] low average daily dietary histidine intake per body mass Low average daily dietary histidine per body mass is an average daily histidine intake per body mass during observed that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for dietary histidine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1691417 Definition source: http://en.wikipedia.org/wiki/Medical_genetics Definition source: http://www.acmg.net clinical geneticist role Clinical geneticist role is a geneticist role that is realized by a human trained in medicine (a physician) during the processes of detection and treatment of patients with various hereditary disorders including birth defects, developmental delay, autism, short stature etc. Curation status: Incomplete. ONSTR:ONSTR_1696794 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 11, 70-81. The acceptable macronutrient distribution range (AMDR) of a macronutrient is expressed as a percentage of total energy intake because its requirement, in a classical sense, is not independent of energy fuel sources or of the total energy requirement of the individual. Each must be expressed in terms relative to the other. A key feature of each AMDR is that it has a lowed and upper boundary. If an individual consumes below or above this range, there is a potential for increasing risk of chronic diseases shown to affect long term health, as well as increasing risk of insufficient intakes of essential nutrients. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp.70.] acceptable macronutrient distribution range datum AMDR acceptable macronutrient distribution range Acceptable macronutrient distribution range datum is a scalar measurement datum that is defined as a range of daily intake of particular dietary energy source that is associated with a reduced risk of chronic disease, while providing adequate intakes of essential macronutrients and that is expressed as percentage of total daily dietary energy intake for particular macronutrient. Curation status: Incomplete ONSTR:ONSTR_1704483 Definition source: ONSTR curators percent estimated average glutamic acid requirement datum Percent estimated average glutamic acid requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of glutamic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for glutamic acid. Curation status: Incomplete ONSTR:ONSTR_1711364 Definition source: ONSTR curators Definition source: http://purl.bioontology.org/ontology/RCD/X74Ug [RCDv3] capillary blood specimen collecting capillary blood sampling Capillary blood specimen collecting is blood specimen collecting by which a portion of capillary blood is collected from a human patient or study subject by making a small puncture (or incision) in capillary blood vessels followed by collecting a portion of (leaked) capillary blood in a protocol appropriate container. Curation status: Incomplete ONSTR:ONSTR_1719621 Definition source: ONSTR curators. percent recommended dietary valine allowance Percent recommended dietary valine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary valine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid valine. Curation status: Incomplete ONSTR:ONSTR_1727488 Definition source: ONSTR curators. average daily dietary glutamine intake during observed time interval average daily dietary Gln intake daily Gln intake Average daily glutamine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid glutamine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_1732077 Definition source: ONSTR curators. upper tolerable nutrient intake level for children population age 4-to-8 years Upper tolerable nutrient intake level for children population age 4-to-8 years is an upper tolerable nutrient intake level for children population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy children population 4 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_1745319 Definition source: http://en.wikipedia.org/wiki/Height_of_a_human_being Definition source: http://purl.bioontology.org/ontology/MSH/D001827 body heigth measurement assay Body height measurement assay is length measurement assay that determines the linear distance between the sole (bottom of the feet) to the crown (top) of the head of human body standing or lying fully extended. In human beings capable of standing erect, body height is measured while a human is standing with legs, spine and neck fully extended. In neonates and infants, the linear distance between the bottom of the feet to the top of the head is measured when neonate or infant is lying with legs fully extended. Curation status: Incomplete ONSTR:ONSTR_1757060 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.380-384. normal average daily dietary selenium intake normal mean selenium intake normal selenium intake Normal average daily dietary selenium intake is an average daily dietary selenium intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary selenium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1759467 Definition source: ONSTR curators. average daily dietary potassium intake during observed time interval average dietary K intake daily dietary potassium intake daily kalium intake daily potassium intake mean kalium intake mean potassium intake Average daily dietary potassium intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary potassium contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_1769497 Definition source: ONSTR curators. average daily dietary molybdenum intake per body mass during observed time interval Average daily dietary molybdenum intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary molybdenum contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_1773106 Definition source: ONSTR curators percent adequate boron intake datum Percent adequate boron intake is a percent adequate dietary mineral intake that provides the information about the quantity boron consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for boron. Curation status: Incomplete ONSTR:ONSTR_1775075 Definition source: ONSTR curators percent upper tolerable vitamin C intake level datum Percent upper tolerable vitamin C intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of vitamin C consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for vitamin C. Curation status: Incomplete ONSTR:ONSTR_1783915 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.122-139. high average daily dietary alpha-linolenic acid intake high alpha-linolenic acid intake high daily alpha-linolenic acid intake high mean alpha-linolenic acid intake High average daily dietary alpha-linolenic acid intake is an average daily dietary alpha-linolenic acid intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary alpha-linolenic acid (aLnA) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1791189 Definition source: ONSTR curators. blood plasma homocystine concentration measurement datum blood homocystine concentration blood homocystine level plasma homocystine concentration plasma homocystine measurement Blood plasma homocystine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid homocystine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_1792329 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 6-12. recommended dietary allowance datum DRI-RDA RDA RDAs dietary reference intake-recommended dietary allowance nutrient recommended daily allowance recommended daily allowance Recommended dietary allowance datum is a dietary nutrient reference intake datum that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of humans in a particular group based on age, gender and gender specific physiological status of being pregnant or lactating. Curation status: Incomplete ONSTR:ONSTR_1815160 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. low average daily dietary intake of phenylalanine and tyrosine combined Low average daily dietary intake of phenylalanine and tyrosine combined is an average daily dietary intake during observed time interval of methionine and cysteine combined that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary phenylalanine and tyrosine combined for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_1837313 Definition source: ONSTR curators percent estimated average nutrient requirement datum %EAR percent DRI-EAR percent EAR Percent estimated average nutrient requirement datum is a percent dietary reference intake that provides the information about the quantity of specific dietary nutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement (EAR) for the observed nutrient. Curation status: Incomplete ONSTR:ONSTR_1838254 Definition source: ONSTR curators. average daily dietary riboflavin intake during observed time interval average daily dietary vitamin B2 intake during observed time interval daily dietary riboflavin intake daily dietary vitamin B2 intake daily vitamin B2 intake mean riboflavine intake Average daily dietary riboflavin intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of riboflavin contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_1851180 Definition source: ONSTR curators. adequate nutrient intake male population age 19-to-30 years Adequate nutrient intake for male population age 19-to-30 years is an adequate nutrient intake for male population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy male population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_1852639 Definition source: ONSTR curators percent adequate phenylalanine intake datum Percent adequate phenylalanine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid phenylalanine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for phenylalanine. Curation status: Incomplete ONSTR:ONSTR_1867414 Definition source: ONSTR curators. percent recommended dietary fiber allowance Percent recommended dietary fiber allowance is a percent recommended dietary macronutrient allowance that provides the information about the total quantity of all dietary fibers combines, consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for dietary fiber. Curation status: Incomplete 7.0 12.0 30.0 7.0 70.0 1.0 4.0 22.0 19.0 15.0 14.0 19.0 9.0 14.0 17.0 4.0 9.0 9.0 14.0 18.0 14.0 19.0 16.0 20.0 24.0 15.0 ONSTR:ONSTR_1868713 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] low average daily dietary isoleucine intake per body mass Low average daily dietary isoleucine per body mass is an average daily isoleucine intake per body mass during observed that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for dietary isoleucine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1884454 Definition source: Asfaw, M., Buchanan, C., Davis, R., Glassman, M., Noakes, W., O'Leary, E.,Wasseff, S. (1993) Pediatric parenteral nutrition support handobook. Nutrition support service, Egleston Children's Hospital, Emory University, Atlanta, GA, pp. 6-10. Definition source: Guidelines on paediatric parenteral nutrition: 4. Lipids. Journal of pediatric and nutrition, Vol 41, Suppl. 2, S19-S27, November 2005. Definition source: Hovasi Cox, J., Melbardis, I. M. (2005) Parenteral nutrition. In Handbook of pediatric nutrition, 3rd Ed. Jones and Bartlett publishers Inc. pp. 525-557. parenteral lipid solution IVFE intralipid solution intravenous fat emulsion intravenous lipid emulsion parenteral lipid emulsion Parenteral lipid solution is a parenteral nutrition solution that is a sterile fat emulsion (e.g. soybean or olive oil based) usually contains a mixture of essential fatty acids, egg yolk phospholipids and glycerol to make the emulsion isotonic, and may contain medium-chain triglicerides. Curation status: Incomplete ONSTR:ONSTR_1888775 Definition source: ONSTR curators. average daily total dietary carotenoid intake per body mass during observed time interval Average daily total dietary carotenoid intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of all carotenoids combined and contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_1894545 Definition source: ONSTR curators percent adequate glycine intake datum Percent adequate glycine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid glycine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for glycine. Curation status: Incomplete ONSTR:ONSTR_1900862 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 birth-to-36-months length-for-age percentile chart infant height-for-age percentile chart infant length-for-age percentile chart length-for-age chart length-for-age percentile chart Birth-to-36-months length-for-age percentile chart is a height-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of height measurement data (body height measurements) with respect to age in a population of healthy infants 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_1904740 Definition source: ONSTR curators percent estimated average vitamin D requirement datum Percent estimated average vitamin D requirement is a percent estimated average vitamin requirement that provides the information about the quantity of vitamin D consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for vitamin D. Curation status: Incomplete ONSTR:ONSTR_1911808 Definition source: ONSTR curators. average daily dietary vitamin K intake per body mass during observed time interval Average daily dietary vitamin K intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of vitamin K contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_1921252 Definition source: ONSTR curators. recommended dietary allowance for male population Recommended dietary allowance for male population is a recommended dietary allowance for population age 9 years and older that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy male population age 9 years and older. Curation status: Incomplete ONSTR:ONSTR_1936669 Definition source: ONSTR curators percent estimated average sulfate requirement datum Percent estimated average sulfate requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of sulfate consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for sulfate. Curation status: Incomplete ONSTR:ONSTR_1942723 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.234-243. normal average daily dietary vitamin K intake normal mean vitamin K intake normal vitamin K intake Normal average daily dietary vitamin K intake is an average daily dietary vitamin K intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary vitamin K for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_1980971 Definition source: ONSTR curators percent upper tolerable vitamin B12 intake level datum Percent upper tolerable vitamin B12 intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of vitamin B12 consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for vitamin B12. Curation status: Incomplete ONSTR:ONSTR_1983024 Definition source: ONSTR curators. recommended dietary allowance for infant population Recommended dietary allowance for infant population is a recommended dietary allowance for population age 0-to-8 years that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy infant population 0 to 12 months of age. Curation status: Incomplete ONSTR:ONSTR_1987347 Definition source: ONSTR curators. prescribed nutritional formula datum Prescribed nutritional formula datum is a nutritional formula datum that provides the information about the kinds and quantities of nutritional formulas prescribed by a dietitian to be consumed by a human patient. Curation status: Incomplete ONSTR:ONSTR_2000067 Definition source: ONSTR curators percent estimated average tryptophan requirement datum Percent estimated average tryptophan requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid tryptophan consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for tryptophan. Curation status: Incomplete ONSTR:ONSTR_2032826 Definition source: ONSTR curators. adequate nutrient intake for lactating female population age 19-to-30 years Adequate nutrient intake for lactating female population age 19-to-30 years is an adequate nutrient intake for lactating population that that denotes the average daily intake of a nutrient based on the observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy lactating female population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_2036859 Definition source: ONSTR curators. rate process profile Rate process profile is a process profile that is a part of a process and that can be mathematically expressed as a ratio of a measurement of a particular quality magnitude over time. Curation status: Incomplete ONSTR:ONSTR_2038914 Definition source: ONSTR curators. body quality Body quality is organismal quality that inheres in human body or a part of the human body. Curation status: Incomplete ONSTR:ONSTR_2055480 Definition source: http://en.wikipedia.org/wiki/Dried_blood_spot dried blood spot eluate Dried blood spot eluate is a processed specimen that is the output of the process of blood elution using a small disk punched from a blood saturated filter paper. The disk punched from a filer paper is dropped into a flat bottom microtitre plate and blood is eluted out in phosphate buffered saline solution containing 0.05% Tween 80 and 0.005% sodium azide, overnight at 4 °C. Curation status: Incomplete This calss may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ONSTR:ONSTR_2065788 Definition source: ONSTR curators. percent daily energy intake from total carbohydrate intake percent daily energy from total carbohydrate percent energy from total carbohydrate Percent daily energy intake from total carbohydrate intake is a percent daily energy intake datum providing the information about the quantity of energy derived from total amount of carbohydrate taken by a patient (enterally or parenterally) during the 24 hour time interval and that is expressed as a percentage of the total dietary energy intake. Curation status: Incomplete ONSTR:ONSTR_2067486 Definition source: ONSTR curators. The quantity of the consumed nutrient that a patient can 'tolerate' while 'staying' within a therapeutic range for that particular nutrient. tolerable nutrient intake datum nutrient intake tolerance Tolerable nutrient intake datum is a nutrient intake datum that provides the information about the quantity of a particluar nutrient that a patient can consume enterally or parenterally during the 24 hours time interval, such that the value of the concentration of the observed nutrient in a bodily fluid (usually blood or urine) measured after the observed 24 hours falls within the therapeutic range for that particular nutrient. Curation status: Incomplete ONSTR:ONSTR_2109859 Definition source: ONSTR curators. recommended dietary allowance for female population age 51-to-70 years Recommended dietary allowance for female population age 51-to-70 years is a recommended dietary allowance for non-pregnant non-lactating female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy female population 51 to 70 years of age. Curation status: Incomplete ONSTR:ONSTR_2111308 Definition source: http://www.w3org/2001/sw/hcls/ns/transmed/TMO_0085 age since birth Age since birth is human age by virtue of (based on) the time elapsed since the moment of birth (i.e. neonate's first breath) until the given time point of age measurement. Curation status: Incomplete ONSTR:ONSTR_2115401 Definition source: ONSTR curators. percent recommended dietary mineral allowance Percent recommended dietary mineral allowance is a percent recommended dietary micronutrient allowance that provides the information about the quantity of particular dietary mineral consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percent of the recommended dietary allowance for the observed dietary mineral. Curation status: Incomplete ONSTR:ONSTR_2131084 Definition source: ONSTR curators percent adequate alpha-linolenic acid intake datum Percent adequate alpha-linolenic acid intake is a percent adequate fatty acid intake that provides the information about the quantity of alpha-linolenic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for alpha-linolenic acid. Curation status: Incomplete ONSTR:ONSTR_2137741 Definition source: ONSTR curators. percent recommended dietary vitamin B6 allowance Percent recommended dietary vitamin B6 allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary vitamin B6 consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for vitamin B6. Curation status: Incomplete ONSTR:ONSTR_2141667 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp.350-355. high average daily dietary manganese intake high manganese intake high mean manganese intake High average daily dietary manganese intake is an average daily dietary manganese intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary manganese for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2143189 Definition source: ONSTR curators percent estimated average arsenic requirement datum Percent estimated average arsenic requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of arsenic consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for arsenic. Curation status: Incomplete ONSTR:ONSTR_2150908 Definition source: ONSTR curators. head circumference measurement datum HC OCF head circumference head circumference measurement occipital-frontal circumference occipitofrontal circumference Head circumference measurement datum is a length measurement datum that is the result of the head circumference measurement process. Curation status: Incomplete ONSTR:ONSTR_2151523 Definition source: ONSTR curators. percent daily energy intake from total fat intake percent daily energy from total fat percent energy from total fat Percent daily energy intake from total fat intake is a percent daily energy intake providing the information about the quantity of energy derived from total amount of fat taken by a patient (enterally or parenterally) during the 24 hour time interval and that is expressed as a percentage of the total dietary energy intake. Curation status: Incomplete ONSTR:ONSTR_2159686 Definition source: ONSTR curators. estimated average nutrient requirement for male population age 70 years and older Estimated average nutrient requirement for male population age 70 and older years is an estimated average nutrient requirement for male population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of male population 70 years of age and older. Curation status: Incomplete ONSTR:ONSTR_2171305 Definition source: ONSTR curators percent upper tolerable asparagine intake level datum Percent upper tolerable asparagine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid asparagine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for asparagine. Curation status: Incomplete ONSTR:ONSTR_2182221 Definition source: ONSTR curators percent adequate copper intake datum Percent adequate copper intake is a percent adequate dietary mineral intake that provides the information about the quantity copper consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for copper. Curation status: Incomplete ONSTR:ONSTR_2186832 Definition source: http://www.cdc.gov/growthcharts/who_charts.htm birth-to-24 months head circumference-for-age weight-for-length WHO growth chart Birth-to-24 months head circumference-for-age weight-for-length percentile chart is a WHO growth chart that consists two vertically separated growth charts pertaining to a population of healthy infants 0 to 24 months of age. The upper section of the combined chart is an head circumference-for-age percentile chart consisting of smoothed percentile curves that illustrate the distribution of head circumference measurements with respect to age. The lower section is a weight-for-length percentile chart consisting of smoothed percentile curves that illustrate the distribution of weight (body mass) measurements with respect to body height measurements (length). Curation status: Incomplete ONSTR:ONSTR_2191830 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.262-269. low average daily dietary pantothenic acid intake low mean pantothenic acid intake low pantothenic acid intake Low average daily dietary pantothenic acid intake is an average daily dietary pantothenic acid intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary pantothenic acid for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2193409 Definition source: ONSTR curators percent estimated average linoleic acid requirement datum Percent estimated average linoleic acid requirement is a percent estimated average fatty acid requirement that provides the information about the quantity of linoleic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for linoleic acid. Curation status: Incomplete ONSTR:ONSTR_2205845 Definition source: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc.(2001) Food and Nutrition Board, Institute of Medicine, National Academy of Sciences, National Academy Press, Washington DC, pp. 770-773. vitamin A specific unit Vitamin A specific unit is a vitamin specific measurement unit denoting the qunatity of vitamin A (retinol) or the quantity of vitamin A precursors (α-carotene, β-carotene and β-cryptoxantin). Curation status: Incomplete ONSTR:ONSTR_2207869 Definition source: http://en.wikipedia.org/wiki/Cofactor_(biochemistry) enzyme cofactor role Enzyme cofactor role is a role of a chemical entity in a biochemical reaction born by a chemical entity (usually a non-protein chemical entity) that is during a biochemical reaction usually bound to the enzyme and that participates in the reaction (usually as ion donor or acceptor) in such way that its chemical composition and/or structure is been altered, but regenerated (recycled) by other enzymes after the chemical entity is been released by the enzyme at the end of reaction. Curation status: Incomplete ONSTR:ONSTR_2220128 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp.234-243. low average daily dietary vitamin E intake low mean vitamin E intake low vitamin E intake Low average daily dietary vitamin E intake is an average daily dietary vitamin E intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary vitamin E for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2224330 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.196-201. low average daily dietary biotin intake low biotin intake low mean biotin intake Low average daily dietary biotin intake is an average daily dietary biotin intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary biotin for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2227179 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. normal average daily dietary leucine intake normal leucine intake normal mean leucine intake Normal average daily dietary leucine intake is an average daily dietary histidine intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary leucine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2239367 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 312-319. low average daily dietary fluoride intake low fluoride intake low mean fluoride intake Low average daily dietary fluoride intake is an average daily dietary fluoride intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary fluoride for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2250468 Definition source: ONSTR curators percent adequate eicosapentaenoic acid intake datum Percent adequate eicosapentaenoic acid intake is a percent adequate fatty acid intake that provides the information about the quantity of eicosapentaenoic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for eicosapentaenoic acid. Curation status: Incomplete ONSTR:ONSTR_2254341 Definition source: ONSTR curators percent estimated average fluoride requirement datum Percent estimated average fluoride requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of fluoride consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for fluoride. Curation status: Incomplete ONSTR:ONSTR_2260479 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 328-339. high average daily dietary magnesium intake high magnesium intake high mean magnesium intake High average daily dietary magnesium intake is an average daily dietary magnesium intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary magnesium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2276485 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 312-319. normal average daily dietary fluoride intake normal fluoride intake normal mean fluoride intake Normal average daily dietary fluoride intake is an average daily dietary fluoride intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary fluoride for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2283226 Definition source: ONSTR curators. adequate nutrient intake for male population age 70 years and older Adequate nutrient intake for male population age 70 years and older is an adequate nutrient intake for male population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy male population age 70 years and older. Curation status: Incomplete ONSTR:ONSTR_2284853 Definition source: ONSTR curators. average daily dietary choline intake during observed time interval mean choline intake Average daily choline intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of choline contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_2285168 Definition source: ONSTR curators. human state with respect to pregnancy and lactation categorical datum Human state with respect to pregnancy and lactation categorical datum is a categorical measurement datum providing the information about the female patient or research study participant being pregnant, lactating or absence of pregnancy or lactation (i.e. non-pregnant non-lactating). Curation status: Incomplete ONSTR:ONSTR_2286225 Definition source: ONSTR curators. average daily total dietary carbohydrate intake during observed time interval mean carbohydrate intake Average daily total dietary carbohydrate intake over observed time interval datum is an average daily dietary macronutrient intake during observed time interval denoting the average intake of dietary carbohydrates (sugars and starches) contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days or three days). Curation status: Incomplete 4.1 250.0 ONSTR:ONSTR_2292205 Definition source: ONSTR curators. NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. positive newborn dried blood spot screening finding for maple syrup urine disease for infants with body mass at birth greater than 2500 grams positive NDBS for MSUD positive NDBS for maple syrup urine disease positive newborn screen for MSUD positive screen for MSUD presumptive positive newborn screen for MSUD presumptive positive screen for MSUD Positive newborn dried blood spot screening finding for maple syrup urine disease for infants with body mass at birth greater than 2500 grams is a newborn dried blood spot screening finding for infants with body mass greater than 2500 grams that is based on abnormally high whole blood concentration of valine (greater than 250 μM), abnormally high isoleucine and leucine combined concentration (greater than 350 μM) and abnormally high ratio between leucine and phenylalanine concentration (greater than 4.1), while the concentrations of other relevant amino acids, carnitine and carnitine esters, and relevant chemical concentration ratios fall within the laboratory established normal ranges. Curation status: Incomplete ONSTR:ONSTR_2293279 Definition source: ONSTR curators percent estimated average carbohydrate requirement datum Percent estimated average carbohydrate requirement is a percent estimated average macronutrient requirement that provides the information about the total quantity of all carbohydrates consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for (total) carbohydrate intake. Curation status: Incomplete ONSTR:ONSTR_2304455 Definition source: ONSTR curators percent estimated average vitamin A requirement datum Percent estimated average vitamin A requirement is a percent estimated average vitamin requirement that provides the information about the quantity of vitamin A consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for vitamin A. Curation status: Incomplete ONSTR:ONSTR_2304763 Definition source: ONSTR curators. age at newborn screening system process measurement datum Age at newborn screening system process measurement datum is age since birth measurement datum that is the result of measurement of time elapsed from birth of the neonate until the time when the age measurement is done during one of the newborn screening system processes (i.e. dried blood spot specimen creation or hearing screening or pulse oximetry screening for critical congenital heart disorders, short-term follow-up or long-ter-follow up). Curation status: Incomplete ONSTR:ONSTR_2318762 Definition source: ONSTR curators percent upper tolerable macronutrient intake level datum Percent upper tolerable macronutrient intake level is a percent upper tolerable nutrient intake level datum that provides the information about the quantity of specific macronutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed macronutrient. Curation status: Incomplete 7.0 12.0 9.0 7.0 17.0 1.0 4.0 6.0 14.0 19.0 4.0 14.0 5.0 14.0 19.0 19.0 4.0 5.0 7.0 15.0 ONSTR:ONSTR_2320418 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] low average daily dietary tryptophan intake per body mass Low average daily dietary tryptophan per body mass is an average daily tryptophan intake per body mass during observed that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for dietary tryptophan intake per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2324370 Definition source: ONSTR curators. adequate nutrient intake for female population Adequate nutrient intake for female population is an adequate nutrient intake for population age 9 years and older that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy female population age 9 years and older. Curation status: Incomplete ONSTR:ONSTR_2338725 Definition source: ONSTR curators. height-for-age percentile Body height [Percentile] Child height centile baby length centile body height growth percentile body height-for-age-percentile length-for-age percentile Height-for-age percentile is a developmental growth indicator showing the percentage of children (in a reference population distribution) that are of the same age as the assessed child, and whose height measurement datum has equal or smaller value than that of the child being assessed at the time of given physical examination. Curation status: Incomplete ONSTR:ONSTR_2341657 Definition source: ONSTR curators percent estimated average zinc requirement datum Percent estimated average zinc requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of zinc consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for zinc. Curation status: Incomplete ONSTR:ONSTR_2363484 Definition source: ONSTR curators. percent recommended dietary sodium allowance Percent recommended dietary sodium allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary sodium consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for sodium. Curation status: Incomplete ONSTR:ONSTR_2366136 Definition source: http://mayomedicallaboratories.com/articles/vitamind/index.htm Definition source: http://nim.nih.gov/medlineplus/ency/article/003569.htm Definition source: http://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ blood vitamin D concentration measurement datum blood vitamin D level blood vitamin D status Blood vitamin D concentration measurement datum is a concentration measurement datum that is the output of liquid chromatography-tandem mass spectrometry, ligand binding assay or radioimmunoassay and that provides the information about the quantity of specific form of vitamin D in the blood sample (blood plasma or serum). Curation status: Incomplete ONSTR:ONSTR_2372433 Definition source: ONSTR curators percent adequate vanadium intake datum Percent adequate vanadium intake is a percent adequate dietary mineral intake that provides the information about the quantity vanadium consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for vanadium. Curation status: Incomplete ONSTR:ONSTR_2392336 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. 2006. The National academies press, Washington DC., pp. 6-12. The UL is not a recommended level of intake, but rather the highest level that can be tolerated without the possibility of causing ill effects. The value applies to chronic daily use and is usually based on total intake of a nutrient from food, water, and supplements if adverse effects have been associated with total intake. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 12.] upper tolerable nutrient intake level datum UL ULs upper tolerable intake datum upper tolerable level upper tolerable levels Upper tolerable nutrient intake level datum is a dietary nutrient reference intake datum that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of a particular population. Curation status: Incomplete ONSTR:ONSTR_2397558 CDC individual growth charts were published in three sets differing in selected percentile curves to meet the needs of various users. Set 1 contains 16 charts (8 for boys and 8 for girls), with the 3rd, 5th, 10th, 25th, 50th, 75th, 90th ,95th, and 97th smoothed percentile curves for all charts, and the 85th percentile for BMI-for-age and weight-for-stature. Set 2 contains 16 charts (8 for boys and 8 for girls), with the 5th, 10th, 25th, 50th, 75th, 90th, and 95th smoothed percentile lines for all charts, and the 85th percentile for BMI-for-age and weight-for-stature. Set 3 contains 16 charts (8 for boys and 8 for girls), with the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th smoothed percentile lines for all charts, and the 85th percentile for BMI-for-age and weight-for-stature. [Source: http://www.cdc.gov/growthcharts/charts.htm#Summary] Definition source: 2000 CDC Growth Charts for the United States: Methods and development, Vital and Health Statistics, Series 11, Number 246, Department of Health and Human Services, CDC National Center for Health Statistics, Hyattsville, MD, May 2002, pp 1 and 20-34. Definition source: http://www.cdc.gov/growthcharts/charts.htm#Summary CDC individual growth chart growth chart CDC individual growth chart is a CDC growth chart that contains sex and age specific smoothed percentile curves for observed pair of phenotypic qualities (e.g. age and body height). Each individual growth chart contains smoothed curves for selected percentiles plotted on a grid that is scaled to international units of measurement (kg, cm) and has secondary scale in British colonial units (lb, in). Individual growth charts are available for infants, birth to 36 months of age and for children and adolescents 2 to 20 years of age, and preschoolers 2 to 5 years of age. Curation status: Incomplete ONSTR:ONSTR_2399802 Definition source: Ogier de Baulny H., Abadie V., Feillet, F., (2007) Management of phenylketonuria and hypephenylalaninemia. The Journal of Nutrition, June 2007, vol. 137, No. 6, pp. 1561S-1563S. transient neonatal hyperphenylalaninemia transitory neonatal hyperphenylalaninemia Transient neonatal hyperphenylalaninemia is transient hyperphenylalaninemia that and occurs in small-for-gestation-age human newborns and that is characterized by elevated concentration of phenylalanine (and related metabolites: phenylpyruvate, phenyllactate, phenylacetate and phenylacetylglutamine) in the neonate's blood and urine, due to incomplete maturation of liver cells that produce the enzyme (protein) phenylalnine hydroxylase. Curation status: Incomplete ONSTR:ONSTR_2403069 Definition source: ONSTR curators. blood carnitine concentration measurement datum Blood carnitine concentration measurement datum is a blood chemical concentration measurement datum that provides the information about the quantity of carnitine in the human blood eluate or blood plasma specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete 7.0 12.0 58.0 7.0 125.0 1.0 4.0 41.0 19.0 27.0 14.0 19.0 9.0 14.0 31.0 4.0 9.0 9.0 14.0 33.0 14.0 19.0 28.0 36.0 41.0 15.0 ONSTR:ONSTR_2413154 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. low average daily dietary intake per body mass of phenylalanine and tyrosine combined Low average daily dietary intake per body mass of phenylalanine and tyrosine combined is an average daily dietary intake per body mass of methionine and cysteine combined that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for dietary phenylalanine and tyrosine combined per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2422189 Definition source: http://purl.bioontology.org/ontology/RCD/Ua1J4 [RCDv3] urine specimen collecting Urine specimen collecting is collecting specimen from an organism whereby a portion urine is collected from a human patient or study subject and stored in protocol appropriate container for further analysis. Curation status: Incomplete ONSTR:ONSTR_2424755 Definition source: Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.14. Definition source: http://purl.bioontology.org/ontology/GO/GO_0004505 phenylalanine hydroxylase complex 4-hydroxylase phenylalanine 4-monooxygenase, phenylalanine L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) PAH PAH complex PheH PheOH hydroxylase, phenylalanine phenylalaninase phenylalanine 4 hydroxylase phenylalanine 4 monooxygenase phenylalanine 4-monooxygenase phenylalanine hydroxylase complex A monooxygenase complex that functions as a catalyst in the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin (a conversion of phenylalanine into tyrosine), which represents a rate limiting step in only clinically significant biochemical pathway for the catabolism of phenylalanine. Curation status: Incomplete 7.0 12.0 22.0 32.0 7.0 28.0 36.0 1.0 4.0 16.0 21.0 4.0 9.0 13.0 16.0 19.0 11.0 14.0 14.0 19.0 9.0 14.0 12.0 15.0 14.0 19.0 12.0 14.0 9.0 14.0 13.0 17.0 15.0 18.0 15.0 19.0 15.0 ONSTR:ONSTR_2440234 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] normal average daily dietary histidine intake per body mass Normal average daily dietary histidine per body mass is an average daily histidine intake per body mass during observed that has the value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) for dietary histidine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2447364 Definition source: ONSTR curators. age at newborn dried blood spot screening specimen collection measurement datum Age at newborn dried blood spot screening specimen collection measurement datum is age since birth measurement datum that is the result of measurement of time elapsed from birth of the neonate until the time when the dried blood spot specimen has been created from a portion of newborn' arterial blood obtained by a heel prick procedure. Curation status: Incomplete ONSTR:ONSTR_2448715 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.370-379. normal average daily dietary potassium intake normal kalium intake normal mean kalium intake normal mean potassium intake normal potassium intake Normal average daily dietary potassium intake is an average daily dietary potassium intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary potassium (kalium) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete 450.0 ONSTR:ONSTR_2465611 Definition source: ONSTR curators. NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. critical positive newborn dried blood spot screening finding for maple syrup urine disease for infants with body mass at birth greater than 2500 grams critical MSUD screen critical NDBS screen for MSUD critical newborn screen for maple syrup urine disease critical screen for MSUD Critical positive newborn dried blood spot screening finding for maple syrup urine disease for infants with body mass at birth greater than 2500 grams is a positive newborn dried blood spot screening finding for maple syrup urine disease for infants with body mass at birth greater than 2500 grams that is based on abnormally high whole blood concentration of valine (greater than 250 μM), abnormally high isoleucine and leucine combined concentration (greater than 460 μM), and abnormally high ratio between leucine and phenylalanine concentration (greater than 4.1). This type of positive newborn dried blood spot screening finding for maple syrup urine disease requires immediate medical attention and/or intervention and treatment initiation. Curation status: Incomplete ONSTR:ONSTR_2466421 Definition source: ONSTR curators. whole blood phenylalanine concentration measurement datum blood Phe blood Phe concentration blood Phe level blood Phe status blood phenylalanine concentration blood phenylalanine level blood phenylalanine measurement blood phenylalanine status Whole blood phenylalanine concentration measurement datum is a whole blood amino-acid concentration measurement datum that provides the information about the quantity of amino-acid phenylalanine in the dried blood spot specimen (or blood eluate derived from the dried blood spot specimen) that has been collected from patient at least 2.5 or 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_2470194 Definition source: ONSTR curators percent estimated average dietary fiber requirement datum Percent estimated average dietary fiber requirement is a percent estimated average macronutrient requirement that provides the information about the total quantity of dietary fiber consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for (total) dietary fiber intake. Curation status: Incomplete ONSTR:ONSTR_2472784 Definition source: ONSTR curators. estimated average nutrient requirement for lactating female population age 19-to-30 years Estimated average nutrient requirement for lactating female population age 19-to-30 years is an estimated average nutrient requirement for lactating female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of population of lactating females 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_2476516 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp. 386-396. high average daily dietary chloride intake high chloride intake high mean chloride intake High average daily dietary chloride intake is an average daily dietary chloride intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary chloride for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2479742 Definition source: ONSTR curators. upper tolerable nutrient intake level for infant population Upper tolerable nutrient intake level for infant population is an upper tolerable nutrient intake level for population age 0-to-8 years that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy infant population. Curation status: Incomplete ONSTR:ONSTR_2490062 Definition source: ONSTR curators. average daily total dietary water intake per body mass during observed time interval Average daily total dietary water intake per body mass during observed time interval is an average daily dietary macronutrient intake per body mass during observed time interval denoting the average intake of water contained in all nutritional items taken by a human patient during the observed time period with respect to patient's body mass. Curation status: Incomplete ONSTR:ONSTR_2510169 Definition source: ONSTR curators percent adequate folacin intake datum Percent adequate folacin intake is a percent adequate vitamin intake that provides the information about the quantity of folacin consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for folacin. Curation status: Incomplete ONSTR:ONSTR_2514922 Definition source: ONSTR curators Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf Routine repeat screening of all newborns is required in eight states, and several others strongly suggest repeated screening to be performed minimum 24 hours post birth. [Source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf ] repeated newborn dried blood spot screening process Repeated newborn dried blood spot screening process is a dried blood spot newborn screening proper process performed usually several days after the birth in the cases when the result of the initial newborn screening is not conclusive or there exists other reason for screening repetition (e.g. dried blood specimen destroyed and or invalid with respect to medical laboratory specimen specifications). Curation status: Incomplete ONSTR:ONSTR_2522542 Definition source: Vitamin C (ascorbic acid) HPLC retrieved from http://www.alpco.com/pdfs/30/30-2009.pdf blood vitamin C concentration measurement datum blood vitamin C concentration blood vitamin C level blood vitamin C status Blood vitamin C concentration measurement datum is a concentration measurement datum that is the output of the immunoassay or high performance liquid chromatography providing the information about the quantity of the acorbic acid (vitamin C) in the whole or (Lithium-heparine diluted) human blood plasma. Curation status: Incomplete 2.0 120.0 ONSTR:ONSTR_2522662 Definition source: ONSTR curators. hyperphenylalaninemia finding Hyperphenylalaninemia finding is a blood phenylalanine concentration finding based on the value of the blood phenylalanine concentration measurement datum or plasma phenylalanine concentration measurement datum falling within the range that has been clinically and empirically established as higher than that of a healthy human population (i.e. above 120 μmol/L or above 2 mg/dL). Curation status: Incomplete ONSTR:ONSTR_2527031 Definition source: ONSTR curators. adequate nutrient intake for children population Adequate nutrient intake for children population is an adequate nutrient intake for population age 0-to-8 years that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for population of healthy children. Curation status: Incomplete ONSTR:ONSTR_2546618 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.402-413. high average daily dietary zinc intake high mean zinc intake high zinc intake High average daily dietary zinc intake is an average daily dietary zinc intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary zinc for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2551520 Definition source: ONSTR curators. recommended dietary allowance for pregnant female population age 14-to-18 years Recommended dietary allowance for pregnant female population age 14-to-18 years is a recommended dietary allowance for pregnant female population that denotes the the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy pregnant female population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_2560230 Definition source: Charney, P., Malone, A. Eds. (2004) ADA pocket guide to nutrition assessment. American Dietetic Association, pp. 33-39. two day nutritional item intake record 2-d food diary 2-d record 2-day food diary 2-day intake record 2-day record two day food intake two day intake record Two day nutritional item intake record is a nutritional item intake record completed by a patient, patient's parent or caretaker or dietitian, and that contains the information about the types and quantites of consumed food items, nutritional supplements, medical foods and food amino-acid excahnges the patient has consumed in two day time interval prior to the follow-up visit. Curation status: Incomplete ONSTR:ONSTR_2570575 "dietary supplement name" does not denote a class of any given dietary supplement, but refers to a particular of that class. For instance dietary supplement name "Vitamin B12 supplemen" would not denote the class of entities that by their properties can be named as "vitamin B12 supplement". What it would refer to is a particular of the "vitamin B12" class, that is "vitamin B12 supplement Tommy has taken yesterday morning after his breakfast at his grandmother's house in Oxford UK". Definition source: ONSTR curators. dietary supplement name Dietary supplement name is a nutritional item name referring to an instance of specific dietary supplement. Curation status: Incomplete ONSTR:ONSTR_2594192 Definition source: ONSTR curators. percent recommended dietary macronutrient allowance Percent recommended dietary macronutrient allowance is a percent recommended dietary nutrient allowance datum that provides the information about the quantity of particular dietary nutrient consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for that specific dietary nutrient. Curation status: Incomplete ONSTR:ONSTR_2619523 Definition source: ONSTR curators upper tolerable nutrient intake level for phenylketonuria population Upper tolerable nutrient intake level for phenylketonuria population is an upper tolerable nutrient intake level for population witgh inherited metabolic disease that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of population with phenylketonuria. Curation status: Incomplete ONSTR:ONSTR_2625903 Definition source: ONSTR curators. blood tyrosine concentration therapeutic range datum Blood tyrosine concentration therapeutic range datum is a blood amino-acid concentration therapeutic range datum that provides the information about the set of values of blood tyrosine concentration measurements, such that the blood tyrosine concentration values falling within this range do not produce or produce minimal toxic effects to most of the members of the observed population. Curation status: Incomplete ONSTR:ONSTR_2625983 Definition source: ONSTR curators. average daily dietary isoleucine intake during observed time interval average daily dietary Ile intake daily Ile intake mean isoleucine intake Average daily isoleucine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid isoleucine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_2626596 Definition source: ONSTR curators. average daily dietary cholesterol intake per body mass during observed time interval Average daily dietary cholesterol intake per body mass during observed time interval is an average daily dietary macronutrient intake per body mass during observed time interval denoting the average quantity of dietary cholesterol contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_2627773 Definition source: ONSTR curators. average daily dietary sodium intake during observed time interval average Na intake daily dietary sodium intake daily natrium intake daily sodium intake mean natrium intake mean sodium intake Average daily dietary sodium intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary sodium contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_2630892 Definition source: ONSTR curators percent estimated average dietary mineral requirement datum Percent estimated average dietary mineral requirement is a percent estimated average micronutrient requirement that provides the information about the quantity of specific mineral nutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for the observed mineral nutrient. Curation status: Incomplete ONSTR:ONSTR_2636941 Definition source: ONSTR curators. adequate nutrient intake for pregnant female population age 14-to-18 years Adequate nutrient intake for pregnant female population age 14-to-18 years is an adequate nutrient intake for pregnant female population that denotes the average daily intake of a nutrient based on the observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy pregnant female population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_2640387 Definition source: ONSTR curators percent adequate chloride intake datum Percent adequate chloride intake is a percent adequate dietary mineral intake that provides the information about the quantity chloride consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for chloride. Curation status: Incomplete ONSTR:ONSTR_2647953 Definition source: ONSTR curators. urine specimen creation objective Urine specimen creation objective is specimen creation objective to obtain a urine specimen from a human patient to use it as an input for further investigation. Curation status: Incomplete 2500.0 ONSTR:ONSTR_2656024 Definition source: ONSTR curators. newborn dried blood spot screening finding for infants with body mass less than 2500 grams Newborn dried blood spot screening finding for infants with body mass at birth greater than 2500 grams is a newborn dried blood spot screening finding based on newborn's body mass (weight) measured at birth was less than 2500 grams, age of dried blood spot specimen collection and whole blood amino acid, carnitine and carnitine ester concentrations and conentrations' ratios (i.e. blood amino acid and acyl-carnitine profile respectively). Curation status: Incomplete ONSTR:ONSTR_2670301 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.356-361. normal average daily dietary molybdenum intake normal mean molybdenum intake normal molybdenum intake Normal average daily dietary molybdenum intake is an average daily dietary molybdenum intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary molybdenum for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2672569 Definition source: ONSTR curators. head circumference-for-age percentile derivation Head circumference-for-age percentile derivation is developmental growth indicator derivation with the goal to determine (or give best possible approximation of) head circumference-for-age percentile for given child, at the time of physical examination. In order to derive head circumference-for-age percentile, information about child's head circumference and age are plotted with respect to the head circumference and age scales of the age and sex appropriate head circumference-for-age percentile growth chart; the position of the resulting point is then compared with the closest head circumference-for-age percentile curves comprising the circumference-for-age growth chart; head circumference-for-age percentile is then determined (or maximally approximated) based on the closest percentile curve. Curation status: Incomplete ONSTR:ONSTR_2681014 Definition source: http://purl.org/obo/owl/GO#GO_0004497 monooxygenase complex An oxidoreductase complex that functions as a catalyst in the reaction of the incorporation of one atom from molecular oxygen into a compound, and the reduction of the other atom of oxygen to water. Curation status: Incomplete ONSTR:ONSTR_2697318 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. high average daily dietary tryptophan intake high mean tryptophan intake high tryptophan intake High average daily dietary tryptophan intake is an average daily dietary histidine intake during observed time interval that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary tryptophan for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2701259 Definition source: ONSTR curators. adequate nutrient intake male population age 31-to-50 years Adequate nutrient intake for male population age 31-to-50 years is an adequate nutrient intake for male population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy male population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_2703424 Definition source: ONSTR curators. research study participant visit Research study participant visit is a planned process consisting of processes described or defined by a research study protocol and that involve participation of research study participant and one or more researchers. Curation status: Incomplete ONSTR:ONSTR_2706074 Definition source: ONSTR curators. blood plasma isoleucine concentration measurement datum plasma Ile plasma Ile level plasma Ile status plasma isoleucine concentration plasma isoleucine measurement plasma isoleucine status Blood plasma isoleucine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid isoleucine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_2707948 Definition source: http://en.wikipedia.org/wiki/Ferritin Definition source: http://www.prospecbio.com/Ferritin_Human_10_177 The iron integrated into the ferritin complex is in the form of ferrihydrite. The serum ferritin level (the amount of ferriting in the blood) is directly related to the amount of iron stored in the body. [source: http://www.prospecbio.com/Ferritin_Human_10_177] This class actually belongs to the Protein Ontology (PRO) domain, but they don't have one at the this being. If/when PRO team asserts one, this class is going to be deprecated and replaced by the corresponding PRO class. ferritin complex Ferritin complex is a protein complex that is in humans comprised of 24 ferritin subunits (ferritin light chain and ferriting heavy chain ferritin monomers) and iron ions (about 4500 Fe^3+ ions in each complex), and that serves as a main intracellular iron storage. Curation status: Incomplete ONSTR:ONSTR_2709221 Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Inborn_Errors_of_Metabolism congenital metabolic disorder IEM IMD congenital biochemical disorder inborn error of metabolism inherited meatbolic disorder A group of constitutional genetic disorders that are inborn genetic mutations (for particular enzyme) and that result in enzyme absence or disfunction that produces disturbances in metabolic process involving lipids, lysosome storage and amino acids (depending on the enzyme being encoded by mutated gene). Curation status: Incomplete ONSTR:ONSTR_2720052 Definition source: ONSTR curators percent upper tolerable carotenoid intake level datum Percent upper tolerable carotenoid intake level is a percent upper tolerable vitamin intake level that provides the information about the total quantity of all carotenoids combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for (total) carotenoid. Curation status: Incomplete ONSTR:ONSTR_2740580 Definition source: ONSTR curators. percent recommended dietary carbohydrate allowance Percent recommended dietary carbohydrate allowance is a percent recommended dietary macronutrient allowance that provides the information about the total quantity of dietary carbohydrates combined, consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for dietary carbohydrate. Curation status: Incomplete ONSTR:ONSTR_2744700 Definition source: ONSTR curators percent upper tolerable magnesium intake level datum Percent upper tolerable magnesium intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of magnesium consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for magnesium. Curation status: Incomplete ONSTR:ONSTR_2760775 Definition source: ONSTR curators. Vitamin B6 in the ONSTR definition refers to all currently known forms of vitamin B6: pyridoxine (PN), pyridoxine 5'-phosphate (PNP), pyridoxal (PL), pyridoxal 5'-phosphate (PLP), pyridoxamine (PM), pyridoxamine 5'-phosphate (PMP), 4-pyridoxic acid (PA). [Source: http://en.wikipedia.org/wiki/Vitamin_B6 ] average daily dietary vitamin B6 intake during observed time interval daily dietary vitamin B6 intake mean vitamin B6 intake Average daily dietary vitamin B6 intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of vitamin B6 contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_2763839 Definition source: ONSTR curators percent estimated average valine requirement datum Percent estimated average valine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid valine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for valine. Curation status: Incomplete ONSTR:ONSTR_2767108 Definition source: ONSTR curators percent adequate iron intake datum Percent adequate iron intake is a percent adequate dietary mineral intake that provides the information about the quantity iron consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for iron. Curation status: Incomplete ONSTR:ONSTR_2774806 Definition source: ONSTR curators percent adequate dietary fiber intake datum Percent adequate dietary fiber intake is a percent adequate macronutrient intake that provides the information about the total quantity of all dietary fibers combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for (total) dietary fiber. Curation status: Incomplete ONSTR:ONSTR_2779570 Definition source: http://www.cdc.gov/growthcharts/charts.htm Head circumference-for-age percentile charts are available for infants age 0 to 36 months, but not for children and adolescents age 2 to 20 years, as in the case of weight-for-age and height-for-age charts. head circumference-for-age percentile chart HC-for-age percentile chart head circumference-for-age chart Head circumference-for-age percentile chart is a CDC individual growth chart consisting of smoothed percentile curves illustrating the distribution(s) of head circumference measurement data (head circumference measurements) with respect to age in a population of healthy children 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_2786064 Definition source: http://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/ blood vitamin B6 concentration measurement datum plasma vitamin B6 concentration plasma vitamin B6 level plasma vitamin B6 status Blood vitamin B6 concentration measurement datum is a concentration measurement datum that is the output of liquid chromatography-tandem mass spectrometry measuring the total quantity of all vitamin B6 forms present in the blood of more specifically, vitamin B6 in the form of pyridoxal-5''-phosphate, in the human blood plasma specimen. Curation status: Incomplete ONSTR:ONSTR_2799804 Definition source: ONSTR curators percent estimated average glutamine requirement datum Percent estimated average glutamine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid glutamine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for glutamine. Curation status: Incomplete ONSTR:ONSTR_2809886 Definition source: ONSTR curators percent adequate vitamin K intake datum Percent adequate vitamin K intake is a percent adequate vitamin intake that provides the information about the quantity of vitamin K consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for vitamin K. Curation status: Incomplete ONSTR:ONSTR_2814848 Definition source: ONSTR curators. referring a patient to a specialist Referring a patient to a specialist is a health care process that realizes a primary care physician role or newborn screening coordinator role and that consists of providing patient's family with the information about which kind of specialist should patient see to obtain the appropriate care and treatment for positively screened and confirmed disease. Curation status: Incomplete ONSTR:ONSTR_2826200 Definition source: ONSTR curators percent estimated average copper requirement datum Percent estimated average copper requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of copper consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for copper. Curation status: Incomplete ONSTR:ONSTR_2835113 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.188-195. normal average daily dietary vitamin B12 intake normal mean vitamin B12 intake normal vitamin B12 intake Normal average daily dietary vitamin B12 intake is an average daily dietary vitamin B12 intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary vitamin B12 for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2841476 Definition source: ONSTR curators. adequate nutrient intake for female population age 19-to-30 years Adequate nutrient intake for female population age 19-to-30 years is an adequate nutrient intake for non-pregnant non-lactating female population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy female population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_2850127 Definition source: ONSTR curators. consumed nutritional formula datum Consumed nutritional formula datum is a nutritional formula datum providing the information about the kind and the quantity of nutritional formula consumed by a patient during the time interval relevant for the dietary analysis. Curation status: Incomplete ONSTR:ONSTR_2860665 Definition source: ONSTR curators. upper tolerable nutrient intake level for male population age 51-to-70 years Upper tolerable nutrient intake level for male population age 51-to-70 years is an upper tolerable nutrient intake level for male population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy male population 51 to 70 years of age. Curation status: Incomplete ONSTR:ONSTR_2877975 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.362-370. high average daily dietary phosphorus intake high mean phosphorus intake high phosphorus intake High average daily dietary phosphorus intake is an average daily dietary phosphorus intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary phosphorus for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_2880815 Definition source: ONSTR curators. average daily dietary arginine intake during observed time interval average daily dietary Arg intake daily Arg intake Average daily arginine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid arginine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_2889784 Definition source: ONSTR curators. cerebrospinal fluid specimen CSF specimen Cerebrospinal fluid specimen is a specimen that is derived from portion of human cerebrospinal fluid and is specified output of cerebrospinal fluid specimen collecting. Curation status: Incomplete ONSTR:ONSTR_2890352 Definition source: http://www.cdc.gov/growthcharts/who_charts.htm boys birth-to-24 months length-for-age weight-for-age WHO growth chart Birth to 24 months: Boys, Length-for-age and weight-for-age percentiles Boys birth-to-24 months length-for-age weight-for-age WHO growth chart is a birth-to-24 months length-for-age weight-for-age WHO growth chart that illustrates the distribution of body height (length) measurements and weight (body mass) measurements with respect to age in a population of healthy boys 0 to 24 months of age. Curation status: Incomplete ONSTR:ONSTR_2901849 Definition source: ONSTR curators percent adequate niacin intake datum Percent adequate niacin intake is a percent adequate vitamin intake that provides the information about the quantity of niacin consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for niacin. Curation status: Incomplete ONSTR:ONSTR_2926732 Definition source: ONSTR curators. locating patient with positive newborn dried blood spot screening test result Locating patient with positive newborn dried blood spot screening test result is a health care process that realizes primary care physician role and that consists of determining the exact location of a patient with positive newborn dried blood spot screening test result (i.e. whether the patient is taken care of by parents at home or at a particular health care institution). Curation status: Incomplete ONSTR:ONSTR_2959319 Definition source: https://www.metabolicpro.org Need more information and better definition.[SN2014-08-15] MetabolicPro MetabolicPro is a nutrient analysis software that is a commercial web-based program designed specifically for metabolic nutritionists following patients diagnosed with inherited metabolic diseases (inborn errors of metabolism). Curation status: Incomplete ONSTR:ONSTR_2959990 Definition source: ONSTR curators percent upper tolerable alpha-linolenic acid intake level datum Percent upper tolerable alpha-linolenic acid intake level is a percent upper tolerable fatty acid intake level that provides the information about the quantity of alpha-linolenic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for alpha-linolenic acid. Curation status: Incomplete ONSTR:ONSTR_2966439 Definition source: http://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/ blood vitamin B12 concentration measurement datum plasma vitamin B12 concentration plasma vitamin B12 level plasma vitamin B12 status serum vitamin B12 concentration serum vitamin B12 level serum vitamin B12 status Blood vitamin B12 concentration measurement datum is a concentration measurement datum that is the output of the immunoassay (or radioimmunoassay) measuring the quantity of vitamin B12 (in the form of cob(III)alamine and cyanocobalalmine) in the human blood serum or plasma specimen. Curation status: Incomplete ONSTR:ONSTR_2969949 Definition source: ONSTR curators percent estimated average carotenoid requirement datum Percent estimated average carotenoid requirement is a percent estimated average vitamin requirement that provides the information about the total quantity of all carotenoids consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for (total) carotenoids. Curation status: Incomplete ONSTR:ONSTR_2972996 Definition source: ONSTR curators. This class more appropriately fits into the OBI domain. If/when OBI team asserts one, this ONSTR class will eventually be replaced by the newly asserted OBI class. concentration measurement datum Concentration measurement datum is a scalar measurement datum that is the output of the measurement of the amount of a particular substance that is spatially contained (diluted/dispersed/scattered) within another substance. Curation status: Incomplete Concentration of phenylalanine in the blood is 1100 μmol/L. ONSTR:ONSTR_3000175 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp. 304-310. high average daily dietary copper intake high copper intake high mean copper intake High average daily dietary copper intake is an average daily dietary copper intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary copper for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3002634 Definition source: Hinman, A.R., Mann, M.Y., Singh, R.H. (2009) Newborn dried bloodspot screening: mapping the clinical and public health components and activities. Genetics in Medicine, Vol.11, No. 6, June 2009. newborn screening process objective Newborn screening process objective is an objective specification of an objective to identify the newborns who are at high risk of heritable and congenital disorder, before the emergence of disorder signs and symptoms (i.e. in the presymptomatic phase). Curation status: Incomplete ONSTR:ONSTR_3018657 Definition source: ONSTR curators. average daily dietary docosahexaenoic acid intake during observed time interval average daily DHA intake daily DHA intake mean DHA intake Average daily dietary docosahexaenoic acid intake over observed time interval datum is an average daily dietary fatty acid intake during observed time interval denoting the average quantity of docosahexaenoic acid (DHA) contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_3030814 Definition source: ONSTR curators. estimated average nutrient requirement for infants age 7-to-12 months Estimated average nutrient requirement for infants age 0-to-6 months is an estimated average nutrient requirement for infant population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of infant population 7 to 12 months of age. Curation status: Incomplete ONSTR:ONSTR_3033773 Definition source: ONSTR curators. average daily total dietary fat intake during observed time interval mean fat intake Average daily total dietary fat intake over observed time interval datum is an average daily dietary macronutrient intake during observed time interval denoting the average intake of dietary fats contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days or three days). Curation status: Incomplete ONSTR:ONSTR_3041447 Definition source: ONSTR curators. recommended dietary allowance for infant population age 0-to-6 months Recommended dietary allowance for infant population age 0-to-6 months is a recommended dietary allowance for infant population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy infant population 0 to 6 months of age. Curation status: Incomplete ONSTR:ONSTR_3054270 Definition source: ONSTR curators percent upper tolerable leucine intake level datum Percent upper tolerable leucine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid leucine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for leucine. Curation status: Incomplete ONSTR:ONSTR_3061956 Definition source: Academy of Nutrition and Dietetics (2013) International Dietetics and Nutrition Terminology (IDNT) Reference Manual. Standardized language for the Nutrition care process. 4th Ed., pp. 37-48. nutrition diagnosis Nutrition diagnosis is a diagnosis textual entity that is composed by a food and nutrition professional (commonly a registered dietitian) and that is based on the data collected during nutrition assessment process and that (in the form of a statement) provides the information about the nutrition problem to be resolved or improved, the etiology of the problem and patient's signs and symptoms. Curation status: Incomplete ONSTR:ONSTR_3068621 Definition source: ONSTR curators. average daily dietary niacin intake during observed time interval average daily dietary vitamin B3 intake during observed time interval daily dietary niacin intake daily dietary vitamin B3 intake daily vitamin B3 intake mean niacin intake Average daily dietary niacin intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of niacin contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_3102193 Definition source: ONSTR curators. recommended dietary allowance for male population age 9-to-13 years Recommended dietary allowance for male population age 9-to-13 years is a recommended dietary allowance for male population denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy male population 9 to 13 years of age. Curation status: Incomplete ONSTR:ONSTR_3110522 Definition source: ONSTR curators. adequate nutrient intake for female population age 51-to-70 years Adequate nutrient intake for female population age 51-to-70 years is an adequate nutrient intake for non-pregnant non-lactating female population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy female population 51 to 70 years of age. Curation status: Incomplete ONSTR:ONSTR_3113105 Definition source: ONSTR curators. average daily dietary alanine intake per body mass during observed time interval Average daily alanine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid alanine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_3115504 Definition source: ONSTR curators. percent recommended dietary eicosapentaenoic acid allowance Percent recommended dietary eicosapentaenoic acid allowance is a percent recommended dietary fatty acid allowance that provides the information about the quantity of dietary eicosapentaenoic acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for eicosapentaenoic acid. Curation status: Incomplete ONSTR:ONSTR_3129842 Definition source: ONSTR curators. upper tolerable nutrient intake level for male population age 9-to-13 years Upper tolerable nutrient intake level for male population age 9-to-13 years is an upper tolerable nutrient intake level for male population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy male population 9 to 13 years of age. Curation status: Incomplete ONSTR:ONSTR_3129961 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 2-to-20-years stature-for-age percentile chart children and adolescents height-for-age percentile chart children and adolescents stature-for-age percentile chart height-for-age percentile chart height/stature-for-age percentile chart stature-for-age percentile chart 2-to-20-years stature-for-age percentile chart is a height-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of height measurement data (body height measurements) with respect to age in a population of healthy children and adolescents 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_3156588 Definition source: ONSTR curators percent upper tolerable molybdenum intake level datum Percent upper tolerable molybdenum intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of molybdenum consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for molybdenum. Curation status: Incomplete ONSTR:ONSTR_3167688 Definition source: ONSTR curators Some parenteral multivitamin solutions need to be reconstituted (diluted in sterile water) before administration. adult parenteral multivitamin solution Adult parenteral multivitamin solution is a parenteral multivitamin solution formulated for adults and children older than 11 years of age, and for incorporation into intravenous infusions or other kinds of parenteral solutions (e.g. parenteral three-in-one solution). Curation status: Incomplete MVI-12 ONSTR:ONSTR_3179050 Definition source: ONSTR curators. estimated average nutrient requirement for lactating female population age 31-to-50 years Estimated average nutrient requirement for lactating female population age 31-to-50 years is an estimated average nutrient requirement for lactating female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of population of lactating females 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_3179741 Definition source: ONSTR curators. average daily dietary serine intake per body mass during observed time interval Average daily serine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid serine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_3189039 Definition source: ONSTR curators percent adequate fat intake datum Percent adequate fat intake is a percent adequate macronutrient intake that provides the information about the total quantity of all fats combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for (total) fat. Curation status: Incomplete ONSTR:ONSTR_3202058 Definition source: ONSTR curators. whole blood amino-acid concentration measurement datum Whole blood amino-acid concentration measurement datum is a blood amino-acid concentration measurement datum that is the output of bacterial inhibition assay or other assays (electrophoresis, gas chromatography, liquid chromatography, liquid chromatography-mass spectrometry) measuring the concentration of an observed amino-acid in human blood specimen (whole blood specimen, or dried blood spot eluate) that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_3203924 Definition source: Asfaw, M., Buchanan, C., Davis, R., Glassman, M., Noakes, W., O'Leary, E.,Wasseff, S. (1993) Pediatric parenteral nutrition support handobook. Nutrition support service, Egleston Children's Hospital, Emory University, Atlanta, GA, pp. 6-10. parenteral trace element solution parenteral trace mineral solution Parenteral trace element solution is a parenteral nutrition solution containing sterile water and on or more chemical compounds containing trace elements essential for human metabolism. Curation status: Incomplete ONSTR:ONSTR_3208726 Definition source: ONSTR curators. industrially processed food item Industrially processed food item is a processed food item that has been created by food manufacturing industry the production and quality of which has been regulated and licensed by the concerned government authority and whose contents has been specified by a manufacturer. Curation status: Incomplete Canned food products, frozen hamburger, low fat milk, corn flakes, sugar free cookies. ONSTR:ONSTR_3209028 Definition source: ONSTR curators. confirmatory diagnosis for a disease indicated by positive newborn dried blood spot screening finding Confirmatory diagnosis for a disease indicated by positive newborn dried blood spot screening finding is a diagnosis textual entity that is composed by a clinical geneticist and provides the information about assessments and analyses of all the patient laboratory and genetic results and physiological tests leading to the conclusion that the patient without the doubt has the disease for which the patient's newborn dried blood spot screening finding was positive. Curation status: Incomplete ONSTR:ONSTR_3211698 Definition source: Charney, P., Malone, A. Eds. (2004) ADA pocket guide to nutrition assessment. American Dietetic Association, pp. 33-39. Which food items patient often consumed during an observed period of time, patient may select from a provided list of foods. Food frequency record can provide overall evaluation of which nutrients are being consumed over time. [Source: Charney, P., Malone, A. Eds. (2004) ADA pocket guide to nutrition assessment. American Dietetic Association, pp. 33-39.] food frequency record Food frequency record is a nutritional item record that is completed by a patient, patient's parent or caretaker or dietitian, and that contains the information about the nutritional items (food items, dietary supplements) patients frequently consumes. Curation status: Incomplete ONSTR:ONSTR_3215569 Definition source: ONSTR curators. age at long-term follow-up interval visit measurement datum age at follow-up visit Age at long-term ollow-up visit measurement datum is age since birth measurement datum that is the result of measurement of the amount of time a human patient has been living until the day of the follow-up visit during which the age measurement is been performed. Curation status: Incomplete ONSTR:ONSTR_3216989 Definition source: ONSTR curators. age at newborn hearing screening measurement datum Age at newborn hearing screening measurement datum is an age at newborn screening measurement datum that is the result of measurement of time elapsed from birth of the neonate until the time when on of the hearing screening processes has been done on a newborn. Curation status: Incomplete ONSTR:ONSTR_3230535 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 156-166. low average daily total dietary water intake low daily water intake low mean water intake low water intake Low average daily total dietary water intake is an average daily total dietary water intake during observed time interval that has value less than that of the adequate intake (DRI-AI) for total dietary water for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3255175 Definition source: ONSTR curators nutrient intake datum Nutrient intake datum is a nutritional intake measurement datum providing the information about the quantity of observed dietary nutrients that have been consumed or may be consumed by a patient or study subject during the time interval relevant for nutrition assessment or nutrition monitoring. Curation status: Incomplete ONSTR:ONSTR_3258876 Commonly used name 'dietary fiber' is actually a misnomer, since many types of so-called dietary fiber are not of fibrous texture, nor they are all chemically polysaccharides (e.g. waxes are esters). [Source: http://en.wikipedia.org/wiki/Dietary_fiber ] Definition source: http://en.wikipedia.org/wiki/Dietary_fiber dietary fiber Dietary fiber is a molecular entity that may be contained in a food item or dietary supplement that has been ingested by a human, and that is not digestible by human gastrointestinal tract. Chemically, what is commonly called dietary fiber includes non-starch polysaccharides (e.g. cellulose or hemicellulose) and other plant and animal origin such as waxes, chitins, pectins, dextrins, inulin, lignin and oligosaccharides. Curation status: Incomplete ONSTR:ONSTR_3267452 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.196-201. normal average daily dietary biotin intake normal biotin intake normal mean biotin intake Normal average daily dietary biotin intake is an average daily dietary biotin intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary biotin for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3277054 Definition source: ONSTR curators. average daily dietary fluoride intake per body mass during observed time interval Average daily dietary fluoride intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of all dietary fluorides combined and contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete 350.0 450.0 ONSTR:ONSTR_3279560 Definition source: ONSTR curators. NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. non-critical positive newborn dried blood spot screening finding for maple syrup urine disease for infants with body mass at birth greater than 2500 grams non-critical NDBS screen for MSUD non-critical newborn screen for maple syrup urine disease non-critical screen for MSUD Non-critical positive newborn dried blood spot screening finding for maple syrup urine disease for infants with body mass at birth greater than 2500 grams is a positive newborn dried blood spot screening finding for maple syrup urine disease for infants with body mass at birth greater than 2500 grams that is based on abnormally high whole blood concentration of valine (greater than 250 μM), isoleucine and leucine combined concentration in the 350-460 μM range and abnormally high ratio between leucine and phenylalanine concentrations (greater than 4.1). This type of positive newborn dried blood spot screening finding for maple syrup urine disease does not require immediate medical attention and/or intervention and treatment initiation. Curation status: Incomplete 7.0 12.0 84.0 7.0 135.0 1.0 4.0 54.0 19.0 33.0 14.0 19.0 9.0 14.0 38.0 4.0 9.0 9.0 14.0 41.0 14.0 19.0 35.0 44.0 51.0 15.0 ONSTR:ONSTR_3283392 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. high average daily dietary intake per body mass of phenylalanine and tyrosine combined High average daily dietary intake per body mass of phenylalanine and tyrosine combined is an average daily dietary intake per body mass of phenylalanine and tyrosine combined that has value that is equal to that of the recommended dietary allowance (DRI-RDA) for dietary phenylalanine and tyrosine combined per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3290480 Definition source: ONSTR curators. average daily dietary nutrient intake datum Average daily dietary nutrient intake datum is nutrient intake datum that provides the information about the average quantity of observed dietary nutrients that have been consumed by patient or study subject during the time interval relevant for nutrition assessment or nutrition monitoring and that is the output of the nutrient intake analysis. Curation status: Incomplete ONSTR:ONSTR_3296813 Definition source: ONSTR curators. gestational age at birth measurement datum Gestational age at birth measurement datum is age measurement datum that is the result of measurement of the amount of time elapsed human conceptus has spent in utero beginning from the estimated time of conception until the birth. Curation status: Incomplete ONSTR:ONSTR_3314861 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. 2006. Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds. The National academies press, Washington DC., pp. 6-12. upper tolerable nutrient intake level for healthy population Upper tolerable nutrient intake level for healthy population is an upper tolerable nutrient intake level datum that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of a given population of healthy humans. Curation status: Incomplete ONSTR:ONSTR_3326109 Definition source: ONSTR curators. average daily dietary tryptophan intake per body mass during observed time interval Average daily tryptophan intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid tryptophan contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_3346730 Definition source: ONSTR curators. percent daily energy intake datum percent daily dietary energy intake datum percent daily energy intake percent daily nutrinet energy intake Percent daily energy intake datum is a dietary energy intake datum providing the information about the quantity of energy derived from total quantity of specific nutrient taken by a patient (enterally or parenterally) during the 24 hour time interval, and expressed a percentage of the total dietary energy intake, and that is the output of the nutrient intake analysis. Curation status: Incomplete ONSTR:ONSTR_3356966 Definition source: http://www.cdc.gov/growthcharts/who_charts.htm birth-to-24 months length-for-age weight-for-age WHO growth chart Birth-to-24 months length-for-age weight-for-age percentile chart is a WHO growth chart that consists two vertically separated growth charts pertaining to a population of healthy infants 0 to 24 months of age. The upper section of the combined chart is an length-for-age percentile chart consisting of smoothed percentile curves that illustrate the distribution of head circumference measurements with respect to age. The lower section is a weight-for-age percentile chart consisting of smoothed percentile curves that illustrate the distribution of weight (body mass) measurements with respect to body height measurements (length). Curation status: Incomplete ONSTR:ONSTR_3358249 Definition source: ONSTR curators percent adequate leucine intake datum Percent adequate leucine intake is a percent adequate amino acid intake that provides the information about the quantity of amino-acid leucine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for leucine. Curation status: Incomplete ONSTR:ONSTR_3368970 Definition source: ONSTR curators. upper tolerable nutrient intake level for female population age 14-to-18 years Upper tolerable nutrient intake level for female population age 14-to-18 years is an upper tolerable nutrient intake level for non-pregnant non-lactating female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy female population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_3374029 Definition source: http://en.wikipedia.org/wiki/Medical_genetics biochemical geneticist role metabolic geneticist role Biochemical geneticist role is a geneticist role that is realized during the processes of diagnosis and management of patients with inherited metabolic diseases. Curation status: Incomplete. ONSTR:ONSTR_3376147 Definition source: ONSTR curators. whole blood carnitine concentration measurement datum blood carnitine concentraton blood carnitine level whole blood C0 whole blood C0 level whole blood carnitine concentration whole blood carnitine level Whole blood carnitine concentration measurement datum is a blood carnitine measurement datum that provides the information about the quantity of carnitine in the human blood eluate or whole blood specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_3380104 Definition source: ONSTR curators percent adequate micronutrient intake datum Percent adequate micronutrient intake is a percent adequate nutrient intake datum that provides the information about the quantity of specific dietary micronutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for the observed micronutrient. Curation status: Incomplete ONSTR:ONSTR_3380310 Definition source: ONSTR curators. blood plasma glutamic acid concentration measurement datum plasma Glu plasma Glu level plasma Glu status plasma glutamic acid concentration plasma glutamic acid measurement plasma glutamic acid status Blood plasma glutamic acid concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of glutamic acid in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_3418254 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. low average daily dietary leucine intake low leucine intake low mean leucine intake Low average daily dietary leucine intake is an average daily dietary leucine intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary leucine for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_3420637 Definition source: ONSTR curators. nutritional item intake assessment dietary assessment Nutritional item intake assessment is a health care process that realizes dietitian role and that includes processes pertaining to nutrition intake data collection and analysis used in establishing nutrition diagnosis. Curation status: Incomplete ONSTR:ONSTR_3440460 Definition source: ONSTR curators. average daily dietary iron intake during observed time interval average Fe intake daily iron intake mean iron intake Average daily dietary iron intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary iron contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_3449666 Definition source: ONSTR curators. upper tolerable nutrient intake level for male population age 70 years and older Upper tolerable nutrient intake level for male population age 70 years and older is an upper tolerable nutrient intake level for male population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy male population age 70 years and older. Curation status: Incomplete ONSTR:ONSTR_3458769 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. normal average daily dietary intake of phenylalanine and tyrosine combined Normal average daily dietary intake of phenylalanine and tyrosine combined is an average daily dietary intake during observed time interval of methionine and cysteine combined that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary phenylalanine and tyrosine combined for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3459861 Definition source: ONSTR curators. mass per unit mass per unit time Mass per unit unit mass per unit time is a dietary nutrient intake per unit time that is a measure of the number of mass units of a given nutrient substance taken by a human in a given time interval with respect to human body mass. Curation status: Incomplete ONSTR:ONSTR_3461344 Definition source: ONSTR curators. percent recommended dietary arachidonic acid allowance Percent recommended dietary arachidonic acid allowance is a percent recommended dietary fatty acid allowance that provides the information about the quantity of dietary arachidonic acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for arachidonic acid. Curation status: Incomplete 7.0 12.0 30.0 43.0 7.0 70.0 88.0 1.0 4.0 22.0 28.0 19.0 15.0 19.0 14.0 19.0 9.0 14.0 17.0 21.0 4.0 9.0 9.0 14.0 18.0 22.0 14.0 19.0 16.0 19.0 20.0 25.0 24.0 30.0 15.0 ONSTR:ONSTR_3462218 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] normal average daily dietary isoleucine intake per body mass Normal average daily dietary isoleucine per body mass is an average daily isoleucine intake per body mass during observed that has the value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) for dietary isoleucine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3465271 Definition source: ONSTR curators percent adequate potassium intake datum Percent adequate potassium intake is a percent adequate dietary mineral intake that provides the information about the quantity potassium consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for potassium. Curation status: Incomplete ONSTR:ONSTR_3466069 Definition source: ONSTR curators percent adequate vitamin intake datum Percent adequate vitamin intake is a percent adequate micronutrient intake that provides the information about the quantity of specific vitamin consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for the observed vitamin. Curation status: Incomplete ONSTR:ONSTR_3478284 Definition source: ONSTR curators percent adequate amino-acid intake datum Percent adequate amino-acid intake is a percent adequate macronutrient intake that provides the information about the quantity of specific amino-acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for the observed amino-acid. Curation status: Incomplete ONSTR:ONSTR_3479511 Definition source: Kemper, A.R., Boyle, C., Aceves, J., Dougherty, D., Figge, J., Fisch, J.L., Hinman, A.R., Greene, C.L., Kus, C.A., Mille, J., Robertson, D., Therrell, B., Lloyd-Puryear, M., van Dyck, P.C., Howell, R.R. (2008) Long-term follow-up after diagnosis resulting from newborn screening: Statement of the US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children. Genetics in Medicine, Vol.10, No.4. April 2008. newborn screening long-term follow-up process objective Newborn screening long-term follow-up objective is an objective specification of an objective to assure the best possible outcome for individuals with disorders identified through newborn screening. Curation status: Incomplete ONSTR:ONSTR_3480132 Definition source: ONSTR curators percent estimated average niacin requirement datum Percent estimated average niacin requirement is a percent estimated average vitamin requirement that provides the information about the quantity of niacin consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for niacin. Curation status: Incomplete ONSTR:ONSTR_3481491 Definition source: ONSTR curators. percent recommended dietary boron allowance Percent recommended dietary boron allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary boron consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for boron. Curation status: Incomplete ONSTR:ONSTR_3492302 Definition source: ONSTR curators percent upper tolerable chloride intake level datum Percent upper tolerable chloride intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of chloride consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for chloride. Curation status: Incomplete ONSTR:ONSTR_3492370 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 70-81. acceptable macronutrient distribution range for children population age 4-to-18 years Acceptable macronutrient distribution range for children population age 1-to-3 years is an acceptable macronutrient distribution range for children population that is is assumed to adequate for healthy children population 4 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_3502270 Definition source: ONSTR curators. weight-for-height percentile weight-for-height centile Weight-for-height percentile is a developmental growth indicator showing the percentage of children (in a reference population distribution) that are of the same height as the assessed child, and whose weight measurement datum has equal or smaller value than that of the child being assessed at the time of given physical examination. Curation status: Incomplete ONSTR:ONSTR_3503523 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp.350-355. normal average daily dietary manganese intake normal manganese intake normal mean manganese intake Normal average daily dietary manganese intake is an average daily dietary manganese intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary manganese for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3513361 Definition source: ONSTR curators. blood plasma cysteine concentration measurement datum plasma Cys plasma Cys level plasma Cys status plasma cysteine concentration plasma cysteine measurement plasma cysteine status Blood lasma cysteine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid cysteine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_3523936 Definition source: ONSTR curators. newborn screening protocol NBS protocol Newborn screening protocol is a newborn screening system protocol specifying all actions to be performed and agents involved in processes of newborn screening unfolding, in general, relatively shortly after the birth. Curation status: Incomplete. ONSTR:ONSTR_3564480 Definition source: ONSTR curators percent estimated average phenylalanine requirement datum Percent estimated average phenylalanine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid phenylalanine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for phenylalanine. Curation status: Incomplete ONSTR:ONSTR_3567068 Definition source: ONSTR curators. estimated average nutrient requirement for male population age 19-to-30 years Estimated average nutrient requirement for male population age 19-to-30 years is an estimated average nutrient requirement for male population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of male population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_3570827 Definition source: ONSTR curators. average daily dietary arsenic intake per body mass during observed time interval Average daily dietary arsenic intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary arsenic contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_3572302 Definition source: ONSTR curators. processed food item processed food Processed food item is a food item that has been thermally or chemically processed or industrially created prior to being ingested by a human. Curation status: Incomplete ONSTR:ONSTR_3574623 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm Head circumference-for-age weight-for-length percentile chart is available only for infant population 0 to 36 months of age, and not for other age groups (2 to 20 years and 2 to 5 years). head circumference-for-age weight-for-length percentile chart HC-for-age and weight-for-length percentile chart head circumference-for-age and weight-for-length percentile chart Head circumference-for-age weight-for-length percentile chart is a CDC clinical growth chart that consists two vertically separated modified individual growth charts pertaining to a population of healthy infants 0 to 36 months of age. The upper section of the combined chart is a modification of individual head circumference-for-age chart consisting of smoothed percentile curves that illustrate the distribution of head circumference measurements with respect to age. The lower section is a modification of individual weight-for-length chart consisting of smoothed percentile curves that illustrate the distribution of weight (body mass) measurements with respect to body height measurements (length). Curation status: Incomplete ONSTR:ONSTR_3579787 Definition source: ONSTR curators percent estimated average glycine requirement datum Percent estimated average glycine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid glycine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for glycine. Curation status: Incomplete ONSTR:ONSTR_3587453 Definition source: ONSTR curators. tolerable fatty acid intake datum fatty acid intake tolerance fatty acid tolerance Tolerable fatty acid intake datum is a tolerable nutrient intake datum that provides the information about quantity of a particular fatty acid that a patient can consume enterally or parenterally during the 24 hours time interval, such that the value of the concentration of the observed fatty acid in a bodily fluid (usually blood or urine) measured after the observed 24 hours falls within the therapeutic range for that particular fatty acid. Curation status: Incomplete ONSTR:ONSTR_3607920 Definition source: ONSTR curators. enzyme catalytic activity rate process profile enzyme catalytic rate Enzyme catalytic activity rate process profile is a rate process profile that in most broad sense can be conceived as a rise in the concentration of the enzyme substrate over time due to the activity of an enzyme and that depends on whether an enzyme binds one or multiple substrates. Curation status: Incomplete ONSTR:ONSTR_3614873 Definition source: http://www.cdc.gov/growthcharts/ Definition source: http://www.cdc.gov/growthcharts/charts.htm#Summary Growth charts are not intended to be used as a sole diagnostic instrument, but as tools that contribute to forming an overall clinical impression of developmental growth of the child being measured. [Source: http://www.cdc.gov/growthcharts/] developmental growth chart growth chart pediatric growth chart Developmental growth chart is a figure consisting of a series of sex specific smoothed percentile curves drawn against the measurement grid, that illustrate the distribution of selected body measurements with respect to age (or another measurement), which indicate patterns of physical development of healthy children over certain period of time. Growth charts have grids scaled to international unit of measurement (kg, cm), with secondary scale in British colonial units (lb, in) and are available for boys and girls falling in different age ranges. Growth charts are be available as separate documents (one chart per document), or two charts can be combined in a single document (as in case of CDC clinical charts). Curation status: Incomplete ONSTR:ONSTR_3617133 Definition source: ONSTR curators percent estimated average vitamin B6 requirement datum Percent estimated average vitamin B6 requirement is a percent estimated average vitamin requirement that provides the information about the quantity of vitamin B6 consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for vitamin B6. Curation status: Incomplete ONSTR:ONSTR_3617918 Definition source: http://en.wikipedia.org/wiki/infant_formula nutritional formula Nutritional formula is a nutritional item that is a manufactured food product (usually powder) intended to be used as a source of necessary nutrients, sometimes as replacements for conventional food products, usually mixed with water or other liquid prior to ingestion. Curation status: Incomplete ONSTR:ONSTR_3657039 Definition source: ONSTR curators. whole blood concentration of isoleucine and leucine combined measurement datum blood Xleu blood Xleu status blood Xleucine concentration blood Xleucine level blood Xleucine measurement whole blood Xleu level Whole blood concentration of leucine and isoleucine combined measurement datum is a whole blood amino-acid concentration measurement datum that provides the information about the total quantity of amino-acids isoleucine and leucine in the human blood eluate or whole blood specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_3662794 Definition source: ONSTR curators. research study participant data record Research study participant data record is a data collection consisting of all data items pertaining to one particular research study participant and that is collected for research study purposes. Curation status: Incomplete ONSTR:ONSTR_3663890 Definition source: ONSTR curators. average daily dietary manganese intake per body mass during observed time interval Average daily dietary manganese intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary manganese contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_3671318 Definition source: ONSTR curators. patient metabolic control assessment Patient metabolic control assessment is a performing clinical assessment that realizes dietitian role and that has a goal to determine patient's metabolic control (metabolic regulation) of metabolic pathways of interest for a particular patient diagnosed with and inherited metabolic disease. Curation status: Incomplete ONSTR:ONSTR_3673197 Definition source: ONSTR curators. average daily dietary fatty acid intake per body mass during observed time interval Average daily dietary fatty acid intake per body mass during observed time interval is an average daily dietary macronutrient intake per body mass during observed time interval denoting the average intake of fatty acids contained in all nutritional items taken by a human patient during the observed time period with respect to patient's body mass. Curation status: Incomplete ONSTR:ONSTR_3674740 Definition source: ONSTR curators. upper tolerable nutrient intake level for pregnant female population age 19-to-30 years Upper tolerable nutrient intake level for pregnant female population age 19-to-30 years is an upper tolerable nutrient intake level for pregnant female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy pregnant female population 19 to 30 years of age. Curation status: Incomplete 2.0 120.0 ONSTR:ONSTR_3680244 Definition source: ONSTR curators. normal blood phenylalanine concentration finding Normal blood phenylalanine concentration finding is a blood phenylalanine concentration finding that is based on the value of blood phenylalanine concentration measurement datum or plasma phenylalanine concentration measurement datum falling within the range that has been clinically and empirically established as being normal for healthy human population (i.e. below 120 μmol/L or below 2 mg/dL). Curation status: Incomplete ONSTR:ONSTR_3689104 Definition source: ONSTR curators percent estimated average eicosapentaenoic acid requirement datum Percent estimated average eicosapentaenoic acid requirement is a percent estimated average fatty acid requirement that provides the information about the quantity of eicosapentaenoic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for eicosapentaenoic acid. Curation status: Incomplete ONSTR:ONSTR_3689465 Definition source: ONSTR curators. upper tolerable nutrient intake level for pregnant female population age 31-to-50 years Upper tolerable nutrient intake level for pregnant female population age 31-to-50 years is an upper tolerable nutrient intake level for pregnant female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy pregnant female population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_3692303 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.182-187. normal average daily dietary vitamin B6 intake normal mean vitamin B6 intake normal vitamin B6 intake Normal average daily dietary vitamin B6 intake is an average daily dietary vitamin B6 intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary vitamin B6 for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3706807 Definition source: ONSTR curators percent adequate methionine intake datum Percent adequate methionine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid methionine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for methionine. Curation status: Incomplete 7.0 12.0 65.0 7.0 156.0 1.0 4.0 48.0 19.0 34.0 14.0 19.0 9.0 14.0 38.0 4.0 9.0 9.0 14.0 40.0 14.0 19.0 35.0 45.0 50.0 15.0 ONSTR:ONSTR_3713863 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] low average daily dietary leucine intake per body mass Low average daily dietary leucine per body mass is an average daily leucine intake per body mass during observed that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for dietary leucine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3725003 Definition source: ONSTR curators. capillary blood specimen Capillary blood specimen is a blood specimen that is derived from portion of human capillary blood and is specified output of capillary blood specimen collecting. Curation status: Incomplete ONSTR:ONSTR_3735018 Definition source: ONSTR curators. age at repeated newborn screening dried blood spot screening specimen collection measurement datum age at repeated DBS collection Age at repeated newborn screening dried blood spot screening specimen collection measurement datum is age since birth measurement datum that is the result of measurement of time elapsed from birth of the neonate until the instant of repeated newborn screening dried blood spot specimen collection. Curation status: Incomplete ONSTR:ONSTR_3736352 Definition source: ONSTR curators. average daily dietary phosphorus intake during observed time interval average dietary P intake daily dietary phosphorus intake daily phosphorus intake mean phosphorus intake Average daily dietary phosphorus intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary phosphorus contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_3747018 Definition source: Charney, P., Malone, A. Eds. (2004) ADA pocket guide to nutrition assessment. American Dietetic Association, pp. 33-39. three day nutritional item intake record 3-d food diary 3-d record 3-day food diary 3-day intake record 3-day record three day food intake three day food intake record Three day nutritional item intake record is a nutritional item intake record completed by a patient, patient's parent or caretaker or dietitian, and that contains the information about the types and quantites of consumed food items, nutritional supplements, medical foods and food amino-acid excahnges the patient has consumed in two day time interval prior to the follow-up visit. Curation status: Incomplete ONSTR:ONSTR_3765273 Definition source: ONSTR curators. percent recommended dietary histidine allowance Percent recommended dietary histidine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary histidine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid histidine. Curation status: Incomplete ONSTR:ONSTR_3767785 Definition source: ONSTR curators. evaluating a patient for disease specific signs and symptoms Evaluating a patient for disease specific signs and symptoms is a health care process that realizes a primary care physician or nurse role and that consists of determining if a patient presents with signs and symptoms expected to appear as a consequence of the presence of disease patient's newborn dried blood spot screening result was positive for. Curation status: Incomplete ONSTR:ONSTR_3774449 GO:0004505 phenylalanine-4-hydroxylase activity Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. Curation status: Incomplete GO:0004505 ONSTR:ONSTR_3780666 Definition source: ONSTR curators. weight-for-height percentile derivation Weight-for-height percentile derivation is developmental growth indicator derivation with the goal to determine (or give best possible approximation of) weight-for-height percentile for given child at the time of physical examination. In order to derive weight-for-height percentile, information about child's body weight (mass) and height are first plotted with respect to the weight and height scales of the age and sex appropriate weight-for-height growth chart; the position of the resulting point is then compared with closest weight-for-height percentile curves comprising the weight-for-height chart; weight-for-height percentile is then determined (or maximally approximated) based on the closest percentile curve. Curation status: Incomplete ONSTR:ONSTR_3782257 Definition source: ONSTR curators. amino-acid exchange unit Amino-acid exchange unit is a derived unit denoting the number of grams of a given amino-acid contained in consumable food items. Curation status: Incomplete ONSTR:ONSTR_3788590 Definition source: ONSTR curators. blood plasma alanine concentration measurement datum plasma Ala plasma Ala level plasma Ala status plasma alanine concentration plasma alanine measurement plasma alanine status Blood blasma alanine concentration measurement datum is a blood plasma amino acid concentration measurement datum that provides the information about the quantity of amino acid alanine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_3799714 Definition source: ONSTR curators. recommended dietary allowance for non-pregnant non-lactating female population Recommended dietary allowance for non-pregnant non-lactating female population is a recommended dietary allowance for female population that denotes dietary nutrient intake sufficient to meet requirements of 97-98% of healthy non-pregnant non-lactating female population. Curation status: Incomplete ONSTR:ONSTR_3799901 "nutritional formula name" does not denote a class of any given nutritional formula, but refers to a particular of that class. For instance nutritional formula name "Ketonex-2" would not denote the class of entities that by their properties can be named as "Ketonex-2 formula". What it would refer to is a particular of the "Ketonex-2 formula" class, that is it would refer to "a portion of Ketonex-2 formula Lilly has taken yesterday morning after his breakfast at her home in Atlanta GA". Definition source: ONSTR curators. nutritional formula name Nutritional formula name is a nutritional item name referring to an instance of specific nutritional formula. Curation status: Incomplete ONSTR:ONSTR_3812544 Definition source: ONSTR curators. average daily dietary micronutrient intake during observed time interval Average daily dietary micronutrient intake over observed time interval datum is a scalar measurement datum denoting the average quantity of a given micronutrient contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_3815432 Definition source: ONSTR curators percent upper tolerable glycine intake level datum Percent upper tolerable glycine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid glycine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for glycine. Curation status: Incomplete ONSTR:ONSTR_3823316 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 boys birth-to-36-months length-for-age percentile chart Length-for-age percentiles: Boys, birth to 36 months boys length-for-age birth to 36 months percentile chart Boys birth-to-36-months length-for-age percentile chart is a birth-to-36-months length-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of height measurement data (body height measurements) with respect to age in a population of healthy boys 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_3831849 Definition source: ONSTR curators. blood plasma histidine concentration measurement datum plasma His plasma His level plasma His status plasma histidine concentration plasma histidine measurement plasma histidine status Blood plasma histidine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid histidine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_3833901 Definition source: ONSTR curators. percent recommended dietary isoleucine allowance Percent recommended dietary isoleucine allowance is a percent recommended dietary amino acid allowance that provides the information about the quantity of dietary isoleucine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid isoleucine. Curation status: Incomplete ONSTR:ONSTR_3838765 Definition source: ONSTR curators. average daily dietary serine intake during observed time interval average daily dietary Ser intake daily Ser intake Average daily serine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid serine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_3840224 Definition source: ONSTR curators. normal enzyme catalytic activity rate process profile Normal enzyme catalytic activity rate process profile is an enzyme catalytic activity rate process profile that the measurement values thereof fall within normal (average) range for the activity rate of that particular enzyme, obtained under normal physiological conditions (normal cytosolic pH, temperature and substrate saturation). Curation status: Incomplete ONSTR:ONSTR_3840534 Definition source: ONSTR curators. upper tolerable nutrient intake level for children population Upper tolerable nutrient intake level for children population is an upper tolerable nutrient intake level for population age 0-to-8 years that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy children population 1 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_3841004 Definition source: ONSTR curators. blood plasma citrulline concentration measurement datum plasma Cit plasma Cit level plasma Cit status plasma citrulline concentration plasma citrulline level plasma citrulline measurement plasma citrulline status Blood plasma citrulline concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid citrulline in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_3842980 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. low average daily dietary threonine intake low mean threonine intake low threonine intake Low average daily dietary threonine intake is an average daily dietary threonine intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_3845166 Definition source: ONSTR curators percent estimated average macronutrient requirement datum Percent estimated average macronutrient requirement is a percent estimated average requirement datum that provides the information about the quantity of specific macronutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for the observed macronutrient. Curation status: Incomplete ONSTR:ONSTR_3847214 Definition source: ONSTR curators. administered parenteral nutrition datum Administered parenteral nutrition datum is a parenteral nutrition datum that provides the information about the kinds and quantities of parenteral nutrition solution that have been administered to a human patient. Curation status: Incomplete ONSTR:ONSTR_3854145 Definition source: http://medical-dictionary.thefreedictionary.com/hyperphenylalaninemia transient hyperphenylalaninemia Transient hyperphenylalaninemia is a disease charactyerized by temporary abnormal elevation of concentration of phenylalanine (and related metabolites: phenylpyruvate, phenyllactate, phenylacetate and phenylacetylglutamine) in the blood and urine. Curation status: Incomplete ONSTR:ONSTR_3856334 Definition source: ONSTR curators prescribed food item datum Prescribed food item datum is a food item datum that provides the information about the kinds and quantities of food items prescribed by dietitian to be consumed by a human patient. Curation status: Incomplete ONSTR:ONSTR_3860310 Definition source: ONSTR curators. average daily dietary amino-acid intake per body mass during observed time interval Average daily dietary amino-acid intake per body mass during observed time interval is an average daily nutrient intake per body mass during observed time interval information denoting the average quantity of a given amino-acid or two amino-acids combined, contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_3860469 Definition source: ONSTR curators. phenotypic sex categorical datum label Phenotypic sex categorical datum label is a categorical label denoting the category of the phenotypic sex datum. Curation status: Incomplete ONSTR:ONSTR_3872598 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 70-81. acceptable macronutrient distribution range for children population age 1-to-3 years Acceptable macronutrient distribution range for children population age 1-to-3 years is an acceptable macronutrient distribution range for children population that is is assumed to adequate for healthy children population 1 to 3 years of age. Curation status: Incomplete ONSTR:ONSTR_3880350 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.262-269. normal average daily dietary niacin intake normal mean niacin intake normal niacin intake Normal average daily dietary niacin intake is an average daily dietary niacin intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary niacin for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3891411 Definition source: ONSTR curators. percent recommended dietary linoleic acid allowance Percent recommended dietary linoleic acid allowance is a percent recommended dietary fatty acid allowance that provides the information about the quantity of dietary linoleic acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for linoleic acid. Curation status: Incomplete ONSTR:ONSTR_3901624 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. 2006. The National Academies Press, Washington DC., pp. 6-12. If sufficient or adequate scientific evidence available to establish an estimated average requirement (EAR) and thus the RDA (recommended dietary allowance), an AI is usually derived for the nutrient instead. An AI is based on fewer data and incorporate more judgement than is used in establishing EAR and subsequently the RDA. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 11.] The AI is expected to meet or exceed the needs of most individuals in a specific life stage and gender group. When RDA is not available for a nutrient (because an EAR could not be developed), the AI can be used as the guide for an individual'intake. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 11.] adequate nutrient intake datum AI AIs DRI-AI adequate intake adequate intakes dietary reference intake-adequate intake Adequate nutrient intake datum is a dietary nutrient reference intake datum that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake by a healthy population (or populations) that is assumed to be adequate for given population. Curation status: Incomplete ONSTR:ONSTR_3942004 Definition source: ONSTR curators. average daily dietary docosahexaenoic acid intake per body mass during observed time interval average daily DHA intake per body mass daily DHA intake per body mass Average daily dietary docosahexaenoic acid intake per body mass during observed time interval is an average daily dietary fatty acid intake per body mass during observed time interval denoting the average quantity of dietary docosahexaenoic acid (DHA) contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_3951448 Definition source: ONSTR curators percent adequate manganese intake datum Percent adequate manganese intake is a percent adequate dietary mineral intake that provides the information about the quantity manganese consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for manganese. Curation status: Incomplete ONSTR:ONSTR_3953391 Definition source: ONSTR curators percent estimated average fat requirement datum Percent estimated average fat requirement is a percent estimated average macronutrient requirement that provides the information about the total quantity of all fats consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for (total) fat intake. Curation status: Incomplete ONSTR:ONSTR_3961897 Definition source: ONSTR curators percent adequate glutamic acid intake datum Percent adequate glutamic acid intake is a percent adequate amino-acid intake that provides the information about the quantity of glutamic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for glutamic acid. Curation status: Incomplete ONSTR:ONSTR_3967800 Definition source: ONSTR curators. estimated average nutrient requirement for children age 4-to-8 years Estimated average nutrient requirement for children age 4-to-8 years is an estimated average nutrient requirement for children population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of children population 4 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_3977344 Definition source: ONSTR curators. Definition source: Scheuermann, R.H., Ceusters, W., Smith, B. (2009) Toward an Ontological Treatment of Disease and Diagnosis. Proceedings of the 2009 AMIA Summit on Translational Bioinformatics, San Francisco, CA, p.116-120. kidney epithelial cell containing defective phenylalanine-4-hydroxylase complex Kidney epithelial cell containing defective phenylalanine-4-hydroxylase complex is a kidney epithelial cell that contains defective phenylalanine-4-hydroxylase complex and may contain normal phenylalanine-4-hydroxylase complex. Curation status: Incomplete ONSTR:ONSTR_3980112 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.262-269. normal average daily dietary pantothenic acid intake normal mean pantothenic acid intake normal pantothenic acid intake Normal average daily dietary pantothenic acid intake is an average daily dietary pantothenic acid intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary pantothenic acid for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_3983113 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.370-379. low average daily dietary potassium intake low kalium intake low mean kalium intake low mean potassium intake low potassium intake Low average daily dietary potassium intake is an average daily dietary potassium intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary potassium (kalium) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4003104 Definition source: ONSTR curators. newborn hearing screening finding Newborn hearing screening test finding is a newborn screening finding that is the output of interpretation of newborn hearing screening test (auditory brain stem response test and/or otoacoustic emissions test). Curation status: Incomplete ONSTR:ONSTR_4010676 Definition source: ONSTR curators. defective phenylalanine-4-hydroxylase Defective phenylalanine-4-hydroxylase is a phenylalanine-4-hydroxylase (protein) that has abnormal alterations in it's primary, secondary and tertiary structure due to alterations in the PAH gene the phenylalanine-4-hydroxylase protein is translation product of. Curation status: Incomplete ONSTR:ONSTR_4023203 Definition source: ONSTR curators. average daily dietary eicosapentaenoic acid intake during observed time interval average daily EPA intake daily EPA intake mean EPA intake Average daily dietary eicosapentaenoic acid intake over observed time interval datum is an average daily dietary fatty acid intake during observed time interval denoting the average quantity of eicosapentaenoic acid (EPA) contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_4032136 Definition source: ONSTR curators. percent recommended dietary manganese allowance Percent recommended dietary manganese allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary manganese consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for manganese. Curation status: Incomplete ONSTR:ONSTR_4051308 Definition source: ONSTR curators. blood plasma threonine concentration measurement datum plasma Thr plasma Thr level plasma Thr status plasma threonine concentration plasma threonine level plasma threonine measurement plasma threonine status Blood plasma threonine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid threonine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_4052233 Definition source: ONSTR curators. average daily dietary proline intake per body mass during observed time interval Average daily proline intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid proline contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_4054546 Definition source: ONSTR curators. average daily total dietary carbohydrate intake per body mass during observed time interval Average daily total dietary carbohydrate intake per body mass during observed time interval is an average daily dietary macronutrient intake per body mass during observed time interval denoting the average intake of carbohydrates contained in all nutritional items taken by a human patient during the observed time period with respect to patient's body mass. Curation status: Incomplete ONSTR:ONSTR_4054701 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp.328-339. low average daily dietary iron intake low iron intake low mean iron intake Low average daily dietary iron intake is an average daily dietary iron intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary iron for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4057085 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.244-253. high average daily dietary folacin intake high folacin intake high folate intake high folic acid intake high mean folate intake High average daily dietary folacin intake is an average daily dietary folacin intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary folacin (folate) for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4060111 Definition source: ONSTR curators. average daily dietary manganese intake during observed time interval average daily Mn intake daily daily manganese intake daily manganese intake mean manganese intake Average daily dietary manganese intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary manganese contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_4067680 Definition source: ONSTR curators percent upper tolerable fatty acid intake level datum Percent upper tolerable fatty acid intake level is a percent upper tolerable macronutrient intake level that provides the information about the quantity of specific fatty acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for the observed fatty acid. Curation status: Incomplete 7.0 12.0 9.17 7.0 9.1 1.0 4.0 10.77 4.0 9.0 15.2 9.0 14.0 27.2 43.43 38.42 14.0 19.0 46.2 34.5 19.0 56.8 57.35 15.0 ONSTR:ONSTR_4083601 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 144-155. low average daily total dietary protein intake low daily protein intake low mean protein intake low protein intake Low average daily total dietary protein intake is an average daily total dietary protein intake during observed time interval that has value less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for total dietary protein for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4085727 Definition source: ONSTR curators percent upper tolerable linoleic acid intake level datum Percent upper tolerable linoleic acid intake level is a percent upper tolerable fatty acid intake level that provides the information about the quantity of linoleic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for linoleic acid. Curation status: Incomplete ONSTR:ONSTR_4105817 Definition source: ONSTR curators dietary energy intake datum Dietary energy intake datum is a nutritional intake measurement datum that provides the information about the quantity of dietary energy derived from all nutritional items taken by a human patient or study subject during the time interval relevant for dietary analysis and that is the output of the nutrient intake analysis. Curation status: Incomplete ONSTR:ONSTR_4112781 Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Finger_Stick finger-prick blood specimen collecting finger stick Finger-prick capillary blood specimen collecting is capillary blood collecting by which a portion of capillary blood is collected from a human patient or study subject by making a small incision with a lancet in patient's finger, followed by collecting leaked portion of capillary blood into a protocol appropriate container. Curation status: Incomplete 7.0 12.0 39.0 7.0 87.0 1.0 4.0 28.0 19.0 19.0 14.0 19.0 9.0 14.0 22.0 4.0 9.0 9.0 14.0 23.0 14.0 19.0 20.0 25.0 28.0 15.0 ONSTR:ONSTR_4125136 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. low average daily dietary valine intake per body mass Low average daily dietary valine per body mass is an average daily valine intake per body mass during observed that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) or between the values of recommended dietary allowance (DRI-RDA) and estimated average requirement (DRI-EAR) for dietary valine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4126959 Definition source: ONSTR curators. average daily dietary phenylalanine intake during observed time interval average daily dietary Phe intake daily Phe intake Average daily phenylalanine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid phenylalanine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_4137435 Definition source: ONSTR curators. Definition source: http://purl.bioontology.org/ontology/VT/VT_0001259 body mass human body mass Body mass is human body quality that inheres in human body by virtue of the body's proportion of the amount of matter (i.e. the total amount of matter in human body). Curation status: Incomplete ONSTR:ONSTR_4148598 Definition source: ONSTR curators. average daily dietary alpha-linolenic acid intake per body mass during observed time interval average daily aLnA intake per body mass daily aLnA intake per body mass Average daily dietary alpha-linolenic acid intake per body mass during observed time interval is an average daily dietary fatty acid intake per body mass during observed time interval denoting the average quantity of dietary alpha-linolenic acid (aLnA) contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_4150627 Definition source: ONSTR curators. reporting positive newborn dried blood spot screening finding Reporting positive newborn dried blood spot screening finding is a health care process that realizes newborn screening nurse or newborn screening coordinator role and that consists of informing patient's family, primary care physician and state managed newborn screening program about the positive newborn dried blood spot screening finding. Curation status: Incomplete ONSTR:ONSTR_4162447 Definition source: ONSTR curators percent estimated average molybdenum requirement datum Percent estimated average molybdenum requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of molybdenum consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for molybdenum. Curation status: Incomplete ONSTR:ONSTR_4163699 Definition source: ONSTR curators. prescribed parenteral nutrition datum Prescribed parenteral nutrition datum is a parenteral nutrition datum that provides the information about the kinds and quantities of parenteral nutrition solution prescribed by a dietitian (or physician) to be administered to a human patient. Curation status: Incomplete ONSTR:ONSTR_4169315 Definition source: ONSTR curators. percent recommended dietary serine allowance Percent recommended dietary serine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary serine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid serine. Curation status: Incomplete ONSTR:ONSTR_4175006 Definition source: ONSTR curators. parenteral nutrition datum Parenteral nutrition datum is a nutritional item datum that provides the information about the kinds and quantities of parenteral nutrition solution that have been prescribed to be administered or already have been administered to a human patient. Curation status: Incomplete ONSTR:ONSTR_4181226 Definition source: ONSTR curators. blood plasma taurine concentration measurement datum plasma Tau plasma Tau level plasma Tau status plasma taurine concentration plasma taurine level plasma taurine measurement plasma taurine status Blood plasma taurine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid taurine in the human plasma blood specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_4193232 Definition source: ONSTR curators. percent recommended dietary vitamin allowance Percent recommended dietary vitamin allowance is a percent recommended dietary micronutrient allowance that provides the information about the quantity of particular dietary vitamin consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percent of the recommended dietary allowance for the observed dietary vitamin. Curation status: Incomplete ONSTR:ONSTR_4199842 Definition source: ONSTR curators. average daily dietary intake per body mass of methionine and cysteine combined Average daily dietary intake per body mass of methionine and cysteine combined is an average daily dietary amino-acid intake per body mass during observed time interval denoting the average quantity of a amino-acids methionine and cysteine combined, contained in all food items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_4213927 Definition source: ONSTR curators. average daily dietary vitamin K intake during observed time interval mean vitamin K intake Average daily dietary vitamin K intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of vitamin K contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_4217381 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp.328-339. high average daily dietary iron intake high iron intake high mean iron intake High average daily dietary iron intake is an average daily dietary iron intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary iron for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4226828 Definition source: ONSTR curators. blood plasma valine concentration measurement datum plasma Val plasma Val level plasma valine concentration plasma valine measurement Blood plasma valine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid valine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_4241089 Definition source: Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.62-64. homozygous mutant phenylalanine hydroxylase genotype homozygous mutant PAH genotype A mutant PAH genotype that includes two copies of the same mutated PAH monomer allele (one cooy inherited from the mother and one copy iherited from the father). Curation status: Incomplete ONSTR:ONSTR_4275167 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp. 296-303. high average daily dietary chromium intake high chromium intake high mean chromium intake High average daily dietary chromium intake is an average daily dietary chromium intake during observed time interval that has value that is greater than to that of the adequate intake (DRI-AI) for dietary chromium for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4277295 Definition source: ONSTR curators. average daily dietary folacin intake during observed time interval average dietary folic acid intake average dietary vitamin B9 intake average dietary vitamin Bc intake daily B9 intake daily dietary folate intake daily dietary folic acid intake mean folate intake Average daily dietary folacin intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of folacin contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_4280782 Definition source: ONSTR curators. estimated average nutrient requirement for infants age 0-to-6 months Estimated average nutrient requirement for infants age 0-to-6 months is an estimated average nutrient requirement for infant population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of infant population 0 to 6 months of age. Curation status: Incomplete ONSTR:ONSTR_4287288 An important principle underlying DRIs is that they are standards for apparently healthy people and are not meant to be applied to those with acute or chronic disease or for the repletion of nutrient levels in previously deficient individuals. Meeting the recommended intakes for the nutrients would not necessarily provide enough for individuals who are already malnourished, nor would they be adequate for certain disease states marked by increase nutrient requirements. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 13.] Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. 2006. Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds. The National academies press, Washington DC., pp. 6-12. Dietary reference intake is a system of nutrition recommendations designed by the Institute of Medicine of the U.S. National Academy of Sciences and is used both in the United States and in Canada for the general public and health professionals and applied in composition of diets for schools, hospitals, prisons or nursing homes, industrial development of new food stuffs and by healthcare policy makers and public health officials. [Source: http://en.wikipedia.org/wiki/Dietary_Reference_intake ] The Dietary Reference Intakes (DRIs) replace and expand the previous revisions of the RDAs (recommended daily allowances) and RNIs (recommended nutrient intakes) and represent a new approach to setting nutrient values by greatly expanding the scope and application of previous nutrient standards. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 17.] When assessing and planning diets, it is important to be mindful of the limitations in the data that underpin the DRIs and their application, which include the following: 1) The Estimated Average Requirements (EARs) may be based on data from limited number of individuals. 2) For most nutrients, the precise variation in requirements is not known but is approximated. 3) In the absence of evidence to the contrary, variation in individual requirements is assumed to follow a normal distribution. 4) The EAR is often extrapolated from one population group to another. 5) The degree of uncertainty associated with the EAR has not been specified. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 19.] Where data were available, DRIs were divided into 12 life stage groups and also by gender. The life stage groups were chosen by considering variations in the requirements of all of the nutrients under review. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 13.] dietary nutrient reference intake datum DRI dietary reference intake dietary reference intakes Dietary nutrient reference intake datum is a dietary reference intake datum that is intended to be used as a recommended reference value for dietary nutrient intakes established or estimated to meet daily nutritional needs of different population groups. Curation status: Incomplete ONSTR:ONSTR_4311702 Definition source: ONSTR curators. food item quantity datum Food item quantity datum is a nutritional item quantity datum that provides the information about the quantity of a food item (consumed or prescribed). Curation status: Incomplete ONSTR:ONSTR_4324226 Definition source: ONSTR curators. adequate nutrient intake for pregnant female population age 19-to-30 years Adequate nutrient intake for pregnant female population age 19-to-30 years is an adequate nutrient intake for pregnant female population that denotes the average daily intake of a nutrient based on the observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy pregnant female population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_4335147 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.224-233. low average daily dietary vitamin D intake low mean vitamin D intake low vitamin D intake Low average daily dietary vitamin D intake is an average daily dietary vitamin D intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary vitamin D for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4336452 Definition source: ONSTR curators. recommended dietary allowance for population age 0-to-8 years Recommended dietary allowance for population age 0-to-8 years is a recommended dietary allowance datum that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy human population 0 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_4344223 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 312-319. high average daily dietary fluoride intake high fluoride intake high mean fluoride intake High average daily dietary fluoride intake is an average daily dietary fluoride intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary fluoride for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age) Curation status: Incomplete ONSTR:ONSTR_4354065 Definition source: ONSTR curators. average daily dietary silicon intake per body mass during observed time interval Average daily dietary silicon intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary silicon contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_4359369 Definition source: ONSTR curators. percent recommended dietary choline allowance Percent recommended dietary choline allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary choline consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for choline. Curation status: Incomplete ONSTR:ONSTR_4387110 Definition source: ONSTR curators. recommended dietary allowance for male population age 19-to-30 years Recommended dietary allowance for male population age 19-to-30 years is a recommended dietary allowance for male population denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy male population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_4390682 Definition source: http://en.wikipedia.org/wiki/Neonatal_nursing Definition source: http://www.innerbody.com/careers-in-health-/nicu-nurcing-careers.html well-baby nurse role nurse role mother-baby nurse role Well-baby nurse role is a nurse role that is realized in processes of providing nursing care to healthy newborn infants up to 28 days post birth or newborns and to their mothers. Curation status: Incomplete. ONSTR:ONSTR_4392740 Definition source: ONSTR curators. blood amino-acid concentration ratio datum Blood amino-acid concentration ratio datum is a blood chemical concentration ratio datum that provides the information about the ratio of concentrations of clinically relevant amino-acids in the blood. Curation status: Incomplete ONSTR:ONSTR_4395652 Definition source: Charney, P., Malone, A. Eds. (2004) ADA pocket guide to nutrition assessment. American Dietetic Association, pp. 33-39. seven day nutritional item intake record 7-d food diary 7-d record 7-day food diary 7-day intake record 7-day record seven day food intake seven day food intake record Seven day nutritional item intake record is a completed by a patient, patient's parent or caretaker or dietitian, and that contains the information about the types and quantites of consumed food items, nutritional supplements, medical foods and food amino-acid excahnges the patient has consumed in seven day time interval prior to the follow-up visit. Curation status: Incomplete ONSTR:ONSTR_4403020 Definition source: ONSTR curators. percent recommended dietary iodine allowance Percent recommended dietary iodine allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary iodine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for iodine. Curation status: Incomplete ONSTR:ONSTR_4404854 Definition source: ONSTR curators percent adequate choline intake datum Percent adequate choline intake is a percent adequate vitamin intake that provides the information about the quantity of choline consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for choline. Curation status: Incomplete 7.0 12.0 65.0 93.0 7.0 156.0 161.0 1.0 4.0 48.0 63.0 19.0 34.0 42.0 14.0 19.0 9.0 14.0 38.0 47.0 4.0 9.0 9.0 14.0 40.0 49.0 14.0 19.0 35.0 44.0 45.0 56.0 50.0 62.0 15.0 ONSTR:ONSTR_4408301 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] normal average daily dietary leucine intake per body mass Normal average daily dietary leucine per body mass is an average daily leucine intake per body mass during observed that has the value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) for dietary leucine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4421038 Definition source: ONSTR curators. percent recommended dietary fatty acid allowance Percent recommended dietary fatty acid allowance is a percent recommended dietary macronutrient allowance that provides the information about the quantity of dietary fatty acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for observed fatty acid. Curation status: Incomplete ONSTR:ONSTR_4434268 Definition source: ONSTR curators. blood serum transferrin concentration measurement datum blood transferrin level serotransferrin level serotransferrin measurement serum transferrin level serum transferrin measurement Blood serum transferrin concentration measurement datum is a blood chemical concentration measurement datum that provides the information about the concentration of serotransferrin (also known as only 'transferrin') in human blood serum specimen. Curation status: Incomplete ONSTR:ONSTR_4438585 Definition source: ONSTR curators. percent recommended dietary potassium allowance Percent recommended dietary potassium allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary potassium consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for potassium. Curation status: Incomplete ONSTR:ONSTR_4461320 Definition source: ONSTR curators. ordering disorder specific confirmatory test Ordering disease specific confirmatory test is a health care process that realizes primary care physician role and that consists of filling and sending proper laboratory analysis request forms in order to obtain the information needed to confirm the presence or absence of the disease the newborn dried blood spot screening test result was positive for. Curation status: Incomplete ONSTR:ONSTR_4483050 Definition source: ONSTR curators percent adequate fluoride intake datum Percent adequate fluoride intake is a percent adequate dietary mineral intake that provides the information about the quantity fluoride consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for fluoride. Curation status: Incomplete ONSTR:ONSTR_4516298 Definition source: ONSTR curators. upper tolerable nutrient intake level for female population Upper tolerable nutrient intake level for female population is an upper tolerable nutrient intake level for population age 9 years and older that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy female population 9 years or older. Curation status: Incomplete ONSTR:ONSTR_4525530 Definition source: ONSTR curators percent upper tolerable eicosapentaenoic acid intake level datum Percent upper tolerable eicosapentaenoic acid intake level is a percent upper tolerable fatty acid intake level that provides the information about the quantity of eicosapentaenoic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for eicosapentaenoic acid. Curation status: Incomplete ONSTR:ONSTR_4544637 Definition source: ONSTR curators percent adequate arachidonic acid intake datum Percent adequate arachidonic acid intake is a percent adequate fatty acid intake that provides the information about the quantity of arachidonic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for arachidonic acid. Curation status: Incomplete ONSTR:ONSTR_4547815 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp. 304-310. low average daily dietary copper intake low copper intake low mean copper intake Low average daily dietary copper intake is an average daily dietary copper intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary copper for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4552868 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.224-233. high average daily dietary vitamin D intake high mean vitamin D intake high vitamin D intake High average daily dietary vitamin D intake is an average daily dietary vitamin D intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary vitamin D for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4561862 Definition source: ONSTR curators. percent recommended dietary alanine allowance Percent recommended dietary alanine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary alanine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid alanine. Curation status: Incomplete ONSTR:ONSTR_4562326 Definition source: Hinman, A.R., Mann, M.Y., Singh, R.H. (2009) Newborn dried bloodspot screening: mapping the clinical and public health components and activities. Genetics in Medicine, Vol.11, No. 6, June 2009. newborn screening system post dried blood spot screening long-term follow-up process LTFU NDBS LTFU NDBS long-termfollow-up NDBS-LTFU newborn dried blood spot screening long-term follow-up Newborn screening system post dried blood spot screening long-term follow-up process is a newborn screening system long-term follow-up process that includes medical and nutrition care processes and that usually starts with the initiation of medical and/or nutritional therapy right after the establishment of the diagnosis following the positive newborn dried blood spot screening finding. Curation status: Incomplete ONSTR:ONSTR_4566787 Definition source: ONSTR curators. adequate nutrient intake for pregnant female population Adequate nutrient intake for pregnant female population is an adequate nutrient intake for female population that denotes the average daily intake of a nutrient based on the observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy pregnant female population. Curation status: Incomplete ONSTR:ONSTR_4568823 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source:[Source:[Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. low average daily dietary isoleucine intake low isoleucine intake low mean isoleucine intake Low average daily dietary isoleucine intake is an average daily dietary isoleucine intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary isoleucine for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_4580525 Definition source: ONSTR curators. average daily total dietary protein intake per body mass during observed time interval Average daily total dietary protein intake per body mass during observed time interval is an average daily dietary macronutrient intake per body mass during observed time interval denoting the average intake of proteins contained in all nutritional items taken by a human patient during the observed time period with respect to patient's body mass. Curation status: Incomplete ONSTR:ONSTR_4584567 Definition source: ONSTR curators. recommended dietary allowance for male population age 31-to-50 years Recommended dietary allowance for male population age 31-to-50 years is a recommended dietary allowance for male population denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy male population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_4596077 Currently, most nutrient databases, as well as nutrition labels, do not distinguish among all the different forms of vitamin E found in food, and still use α-TE, thus including the contribution of all naturally occurring forms of vitamin E. Because the forms of vitamin E other than the naturally occurring form RRR-αtocopherol) do not occur in foods, the intake of α-TE is greater than the intake of α-tocopherol alone, and it is thus recommended that the use of α-TE be abandoned due to the lack of evidence of bioavailability via transport in the blood plasma or tissues. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) DRIs: The essential guide to nutrient requirements. The Insitute of medicine of the National academies. The National academies press, Washington D.C., pp 236-237. ] Definition source: ONSTR curators. Three DRI values for vitamin E (the EAR, RDA and AI) apply only to intake of 2R-stereoizomeric forms of α-tocopherol from food, fortified foods and supplements. The other naturally occuring isomers of vitamin E (β-, γ- and δ-tocopherols and α-, β-, γ- and δ-tocotrienols) do not contribute to meeting the vitamin E requirements, because they are not converted to α-tocopherol in humans. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) DRIs: The essential guide to nutrient requirements. The Insitute of medicine of the National academies. The National academies press, Washington DC, pp 237. ] average daily dietary vitamin E intake per body mass during observed time interval Average daily dietary vitamin E intake per body mass during observed time interval is an average vitamin intake per body mass during observed time interval information denoting the average quantity of vitamin E contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_4596694 Definition source: ONSTR curators. estimated average nutrient requirement for population age 0-to-8 years Estimated average nutrient requirement for population age 0-to-8 years is an estimated average nutrient requirement datum that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of human population of 0 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_4611369 Definition source: ONSTR curators. research study participant data record collection Research study data collection is a data collection consisting of all the data collected from all the research participants during the course of the research study. Curation status: Incomplete ONSTR:ONSTR_4615235 Definition source: ONSTR curators. blood plasma asparagine concentration measurement datum plasma Asn plasma Asn level plasma Asn status plasma asparagine concentration plasma asparagine measurement plasma asparagine status Blood plasma asparagine concentration measurement datum is a blood plasma amino acid concentration measurement datum that provides the information about the quantity of amino acid asparagine in the human plasma blood specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_4636346 Definition source: ONSTR curators. adequate nutrient intake for female population age 31-to-50 years Adequate nutrient intake for female population age 31-to-50 years is an adequate nutrient intake for non-pregnant non-lactating female population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy female population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_4655635 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 girls 2-to-20-years weight-for-age percentile chart Weight-for-age percentiles: Girls, 2 to 20 years girls weight-for-age 2 to 20 years percentile chart Girls 2-to-20-years weight-for-age percentile chart is a 2-to-20-years weight-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of weight measurement data (body mass measurements) with respect to age in a population of healthy girls 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_4662644 Definition source: ONSTR curators. estimated average nutrient requirement for male population Estimated average nutrient requirement for male population is an estimated average nutrient requirement for population age 9 years and older that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of male population of 9 years of age and older. Curation status: Incomplete ONSTR:ONSTR_4675402 Definition source: ONSTR curators. breakfast morning meal Breakfast is a meal usually eaten by a human in the morning or shortly after waking up in the morning after a night sleep. Curation status: Incomplete ONSTR:ONSTR_4678678 Definition source: ONSTR curators percent adequate zinc intake datum Percent adequate zinc intake is a percent adequate dietary mineral intake that provides the information about the quantity zinc consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for zinc. Curation status: Incomplete ONSTR:ONSTR_4679647 Definition source: ONSTR curators. average daily dietary chloride intake per body mass during observed time interval Average daily dietary chloride intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of all dietary chlorides combined and contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_4696269 Definition source: ONSTR curators. percent recommended dietary protein allowance Percent recommended dietary protein allowance is a percent recommended dietary macronutrient allowance that provides the information about the total quantity of all dietary proteins combined, consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for dietary protein. Curation status: Incomplete ONSTR:ONSTR_4698581 Definition source: ONSTR curators. percent recommended dietary thiamine allowance Percent recommended dietary thiamine allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary thiamine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for thiamine. Curation status: Incomplete ONSTR:ONSTR_4698666 Definition source: ONSTR curators. blood plasma methionine concentration measurement datum plasma Met plasma Met level plasma Met status plasma methionine concentration plasma methionine measurement plasma methionine status Blood plasma methionine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid methionine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_4706181 Definition source: ONSTR curators. pediatric parenteral trace element solution Pediatric trace element nutrient solution is a parenteral trace elements solution containing a combination of certain trace element micronutrients in various amounts, formulated for adults and children older than 11 years of age. Curation status: Incomplete Multitrace-4 Pediatric or Neonatal, Pedtrace-4, PedTE-PAK-4 ONSTR:ONSTR_4721332 Definition source: ONSTR curators. average daily dietary copper intake during observed time interval average Cu intake daily copper intake mean copper intake Average daily dietary copper intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary copper contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_4737543 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm girls 2-to-20 years stature-for-age weight-for-age percentile chart 2 to 20 years: Girls, stature-for-age and weight-for-age percentiles girls stature-for-age and weight-for-age percentile chart girls stature-for-age and weight-for-age percentiles Girls 2-to-20 years stature-for-age weight-for-age percentile chart is a 2-to-20 years stature-for-age weight-for-age percentile chart that illustrates the distributions of height and weight measurement data with respect to age in a population of healthy girls 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_4737847 Definition source: ONSTR curators percent upper tolerable cholesterol intake level datum Percent upper tolerable cholesterol intake level is a percent upper tolerable macronutrient intake level that provides the information about the quantity of cholesterol consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for cholesterol. Curation status: Incomplete ONSTR:ONSTR_4741631 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp.218-223. low average daily dietary choline intake low choline intake low mean choline intake Low average daily dietary choline intake is an average daily dietary choline intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary choline for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4742828 Definition source: ONSTR curators percent upper tolerable valine intake level datum Percent upper tolerable valine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid valine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for valine. Curation status: Incomplete ONSTR:ONSTR_4748813 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.386-396. low average daily dietary sodium intake low mean natrium intake low mean sodium intake low natrium intake low sodium intake Low average daily dietary sodium intake is an average daily dietary sodium intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary sodium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete 7.0 12.0 62.0 86.0 7.0 103.0 107.0 1.0 4.0 45.0 58.0 19.0 31.0 38.0 14.0 19.0 9.0 14.0 35.0 43.0 4.0 9.0 9.0 14.0 37.0 46.0 14.0 19.0 31.0 38.0 41.0 51.0 42.0 52.0 15.0 ONSTR:ONSTR_4749469 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] normal average daily dietary lysine intake per body mass Normal average daily dietary lysine per body mass is an average daily lysine intake per body mass during observed that has the value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) for dietary lysine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4752024 Definition source: ONSTR curators. body height at birth measurement datum Body height at birth measurement datum is a body height measurement datum that is the result of the body height measurement assay performed shortly after birth of a human neonate. Curation status: Incomplete ONSTR:ONSTR_4760059 Definition source: http://www.cdc.gov/growthcharts/who_charts.htm girls birth-to-24 months length-for-age weight-for-age WHO growth chart Birth to 24 months: Girls, Length-for-age and weight-for-age percentiles Girls birth-to-24 months length-for-age weight-for-age WHO growth chart is a birth-to-24 months length-for-age weight-for-age WHO growth chart that illustrates the distribution of body height (length) measurements and weight (body mass) measurements with respect to age in a population of healthy girls 0 to 24 months of age. Curation status: Incomplete ONSTR:ONSTR_4766320 Definition source: Hovasi Cox, J., Melbardis, I. M. (2005) Parenteral nutrition. In Handbook of pediatric nutrition, 3rd Ed. Jones and Bartlett publishers Inc. pp. 525-557. Parenteral two-in-one solution is usually prepared on site, and infused through one arm of a Y-connector, while a parenteral lipid solution is infused through the other arm of the Y-connector. [Source: Hovasi Cox, J., Melbardis, I. M. (2005) Parenteral nutrition. In Handbook of pediatric nutrition, 3rd Ed. Jones and Bartlett publishers Inc. pp. 525-557. ] parenteral two-in-one solution parenteral two-in-one admixture solution two-in-one solution Parenteral two-in-one solution is a parenteral nutrition solution that is a mixture of parenteral dextrose solution and parenteral amino-acid solution. Curation status: Incomplete ONSTR:ONSTR_4767044 Definition source: ONSTR curators. number of newborn dried blood spot screenings per person measurement datum Number of newborn dried blood spot screenings per person measurement datum is a measurement datum providing the information about the total number of times newborn dried blood screenings tests were administered to one particular patient. Curation status: Incomplete ONSTR:ONSTR_4768406 Definition source: ONSTR curators. average daily dietary phosphorus intake per body mass during observed time interval Average daily dietary phosphorus intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary phosphorus contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_4770209 Definition source: ONSTR curators percent estimated average water requirement datum Percent estimated average water requirement is a percent estimated average macronutrient requirement that provides the information about the total quantity of water consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for (total) water intake. Curation status: Incomplete ONSTR:ONSTR_4802516 Definition source: ONSTR curators. percent recommended dietary docosahexaenoic acid allowance Percent recommended dietary docosahexaenoic acid allowance is a percent recommended dietary fatty acid allowance that provides the information about the quantity of dietary docosahexaenoic acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and expressed as percentage of the recommended dietary allowance for docosahexaenoic acid. Curation status: Incomplete ONSTR:ONSTR_4812821 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm girls head circumference-for-age weight-for-length percentile chart Birth to 36 months: Girls, head circumference-for-age and weight-for-length percentiles girls HC-for-age and weight-for-length percentile chart girls head circumference-for-age and weight-for-length percentile chart Girls head circumference-for-age weight-for-length percentile chart is a head circumference-for-age weight-for-length percentile chart that illustrates the distribution of head circumference measurements with respect to age, and weight (body mass) measurements with respect to body height (length) measurements in a population of healthy girls 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_4832670 Definition source: ONSTR curators. age at second newborn dried blood spot specimen collection measurement datum age at second DBS collection Age at second newborn screening dried blood spot specimen collection measurement datum is age at repeated newborn screening dried blood spot collection measurement datum that is the result of measurement of time elapsed from birth of the neonate until the instant of the second newborn screening dried blood spot specimen collection. Curation status: Incomplete ONSTR:ONSTR_4836589 Definition source: ONSTR curators percent adequate silicon intake datum Percent adequate silicon intake is a percent adequate dietary mineral intake that provides the information about the quantity silicon consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for silicon. Curation status: Incomplete ONSTR:ONSTR_4837700 Definition source: ONSTR curators. blood plasma lysine concentration measurement datum plasma Lys plasma Lys level plasma Lys status plasma lysine concentration plasma lysine measurement plasma lysine status Blood plasma lysine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid lysine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_4838542 Definition source: Scriver, C. R., Sly, W. S., Childs, B., Baudet, A. L., Valle, D., Kinzler, K. W., Vogelstein, B. (2000) The metabolic and molecular bases of inherited metabolic disease, 8th Ed. McGraw-Hill Professional. moderate phenylketonuria moderate PKU Moderate phenylketonuria is a hyperphenylalaninemia that is characterized by blood phenyalalnine concentration in the range 900-1200 μmol/L (15-20 mg/dL). Curation status: Incomplete ONSTR:ONSTR_4842426 Definition source: ONSTR curators. percent recommended dietary fluoride allowance Percent recommended dietary fluoride allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary fluoride consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for fluoride. Curation status: Incomplete ONSTR:ONSTR_4846874 Definition source: ONSTR curators. adequate nutrient intake for non-pregnant non-lactating female population Adequate nutrient intake for non-pregnant non-lactating female population is an adequate nutrient intake for female population denoting the average daily intake of a nutrient based on the observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for population of healthy non-pregnant non-lactating females. Curation status: Incomplete ONSTR:ONSTR_4850070 Body mass index-for-age percentile charts are available for only for children and adolescents age 2 to 20 years, but not other age groups (birth to 36 months and 2 to 5 years). Definition source: http://www.cdc.gov/growthcharts/charts.htm body mass index-for-age percentile chart BMI-for-age percentile chart Body mass index-for-age percentile chart is a CDC individual growth chart consisting of smoothed percentile curves illustrating the distribution(s) of body mass indices with respect to age in a population of healthy children and adolescents 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_4852474 "nutritional item name" does not denote a class of any given nutritional item, but refers to a particular of that class. For instance, nutritional item name "carrot" would not denote the class of entities that by their properties can be named as "carrot". What it would refer to is a particular of the "carrot", that is "a carrot that Lori has eaten yesterday after noon at her mom's lighthouse in Cape Code MA". Definition source: ONSTR curators. nutritional item name Nutritional item name is a written name referring to an instance of a nutritional item. Curation status: Incomplete ONSTR:ONSTR_4855812 Definition source: ONSTR curators. average daily dietary nickel intake per body mass during observed time interval Average daily dietary nickel intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary nickel contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_4867208 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. low average daily dietary lysine intake low lysine intake low mean lysine intake Low average daily dietary lysine intake is an average daily dietary lysine intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary lysine for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_4872388 benign hyperphenylalaninemia H-PHE benign hyperPhe mild HPA mild hyperphenylalaninemia Benign hyperphenylalaninemia is a hyperphenylalaninemia characterized by blood phenylalanine concentration in the range 360-600 μmol/L (2 - 10 mg/dL). Curation status: Incomplete ONSTR:ONSTR_4879889 Definition source: ONSTR curators percent estimated average vitamin B12 requirement datum Percent estimated average vitamin B12 requirement is a percent estimated average vitamin requirement that provides the information about the quantity of vitamin B12 consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for vitamin B12. Curation status: Incomplete ONSTR:ONSTR_4888014 CDC clinical charts are published in two sets differing in provided outer percentile curves. Set 1 contains 10 charts (5 for boys and 5 for girls), with the 5th, 10th, 25th, 50th, 75th, 90th, and 95th smoothed percentile lines for all charts, and the 85th percentile for BMI-for-age and weight-for-stature. Set 2 contains 10 charts (5 for boys and 5 for girls), with the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th smoothed percentile lines for all charts, and the 85th percentile for BMI-for-age and weight-for-stature. [Source: http://www.cdc.gov/growthcharts/clinical_charts.htm] Definition source: 2000 CDC Growth Charts for the United States: Methods and development, Vital and Health Statistics, Series 11, Number 246, Department of Health and Human Services, CDC National Center for Health Statistics, Hyattsville, MD, May 2002, pp 1 and 35-44. Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm CDC clinical growth chart clinical growth chart CDC clinical growth chart is a CDC growth chart that consists of modifications in the format of the individual CDC growth charts, whereby two individual charts (for different properties being measured) may appear on a single page. All percentile curves are plotted on a grid scaled to international units of measurement (kg, cm), with secondary scale in British colonial units (lb, in). Additionally, each clinical chart contains data entry tables and spaces for patient relevant information (patient name, ID number etc.). Curation status: Incomplete ONSTR:ONSTR_4896927 Definition source: ONSTR curators percent adequate vitamin E intake datum Percent adequate vitamin E intake is a percent adequate vitamin intake that provides the information about the quantity of vitamin E consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for vitamin E. Curation status: Incomplete ONSTR:ONSTR_4900109 Definition source: ONSTR curators. lunch Lunch is a meal usually eaten by a human during the midday or in the early after noon. Curation status: Incomplete ONSTR:ONSTR_4900837 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.182-187. low average daily dietary vitamin B6 intake low mean vitamin B6 intake low vitamin B6 intake Low average daily dietary vitamin B6 intake is an average daily dietary vitamin B6 intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary vitamin B6 for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4914732 Definition source: ONSTR curators. average daily dietary leucine intake during observed time interval average daily dietary Leu intake daily Leu intake mean leucine intake Average daily leucine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino acid leucine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_4929872 Definition source: ONSTR curtors. hydrolyzed formula Hydrolyzed formula is a nutritional formula that contains hydrolyzed proteins. Curation status: Incomplete Need better definiton for this class. ONSTR:ONSTR_4934345 Definition source: ONSTR curators percent upper tolerable histidine intake level datum Percent upper tolerable histidine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid histidine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for histidine. Curation status: Incomplete ONSTR:ONSTR_4943432 Definition source: ONSTR curators. percent recommended dietary phosphorus allowance Percent recommended dietary phosphorus allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary phosphorus consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for phosphorus. Curation status: Incomplete ONSTR:ONSTR_4943854 Definition source: ONSTR curators percent upper tolerable calcium intake level datum Percent upper tolerable calcium intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of calcium consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for calcium. Curation status: Incomplete ONSTR:ONSTR_4959816 Definition source: ONSTR curators percent estimated average serine requirement datum Percent estimated average serine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid serine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for serine. Curation status: Incomplete ONSTR:ONSTR_4969498 Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf Newborn screening retesting on the original dried blood spot specimen collected during initial newborn screening process should be distinguished from the second- and third-tier testing, and also from the repeated screening test, in the sense that for the purposes of retesting the same test is performed on the same dried blood spot specimen collected for the initial test, while for the second- and third-tier testing different test is done on the dried blood spot specimen collected for the initial test. For the purposes of repeated screening test, a new dried blood spot specimen is created and the same test that has been done on the specimen collected during the initial screening is repeated on the newly provided specimen. [Source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf ]s newborn dried blood spot screening retest process Newborn dried blood spot screening retest is a dried blood spot newborn screening proper process performed by the medical laboratory on the dried blood spot of the original specimen (i.e. the original five dried blood spots) collected during the initial dried blood spot newborn screening process for the purposes of confirming preliminary positive result but before reporting the positive result back to the newborn screening program. Curation status: Incomplete ONSTR:ONSTR_4971909 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 6-12. high average daily total dietary carbohydrate intake high carbohydrate intake high daily carbohydrate intake high mean carbohydrate intake High average daily dietary carbohydrate intake is an average daily total dietary carbohydrate intake during observed time interval that has the value greater than that of the estimated average requirement (DRI-EAR) or the recommended dietary allowance (DRI-RDA) or the adequate intake (DRI-AI) for total dietary carbohydrates for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4978872 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.402-413. normal average daily dietary zinc intake normal mean zinc intake normal zinc intake Normal average daily dietary zinc intake is an average daily dietary zinc intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary zinc for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4986487 Definition source: ONSTR curators. percent recommended dietary pantothenic acid allowance Percent recommended dietary pantothenic acid allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary pantothenic acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for pantothenic acid. Curation status: Incomplete 7.0 12.0 49.0 7.0 87.0 1.0 4.0 32.0 19.0 21.0 14.0 19.0 9.0 14.0 22.0 4.0 9.0 9.0 14.0 24.0 14.0 19.0 21.0 26.0 30.0 15.0 ONSTR:ONSTR_4990710 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acidamino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] high average daily dietary threonine intake per body mass High average daily dietary threonine per body mass is an average daily threonine intake per body mass during observed that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary threonine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_4991400 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 boys 2-to-20-years weight-for-age percentile chart Weight-for-age percentiles: Boys, 2 to 20 years boys weight-for-age 2 to 20 years percentile chart Boys 2-to-20-years weight-for-age percentile chart is a 2-to-20-years weight-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of weight measurement data (body mass measurements) with respect to age in a population of healthy boys 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_4992516 Definition source: ONSTR curators percent adequate aspartic acid intake datum Percent adequate aspartic acid intake is a percent adequate amino-acid intake that provides the information about the quantity of aspartic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for aspartic acid. Curation status: Incomplete ONSTR:ONSTR_4992745 Definition source: ONSTR curators. estimated average nutrient requirement for female population age 14-to-18 years Estimated average nutrient requirement for female population age 14-to-18 years is an estimated average nutrient requirement for non-pregnant non-lactating female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of female population of 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_4998021 Definition source: ONSTR curators. upper tolerable nutrient intake level for female population age 51-to-70 years Upper tolerable nutrient intake level for female population age 51-to-70 years is an upper tolerable nutrient intake level for non-pregnant non-lactating female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy female population 51 to 70 years of age. Curation status: Incomplete ONSTR:ONSTR_4999231 Definition source: ONSTR curators. nutritional formula quantity datum Nutritional formula quantity datum is a nutritional item quantity datum that provides the information about the quantity of the nutritional formula (consumed or prescribed). Curation status: Incomplete ONSTR:ONSTR_4999812 Definition source: ONSTR curators. average daily dietary vitamin B12 intake during observed time interval average daily dietary cobalamine intake during observed time interval daily cobalamine intake daily vitamin B12 intake mean vitamin B12 intake Average daily dietary vitamin B12 intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of vitamin B12 contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_5015919 Definition source: http://www.fda.gov/RegulatoryInformation/Legislation/FederalFoodDrugandCosmeticActFDCAct/SignificantAmendmentstotheFDCAct/OrphanDrugAct/default.htm Medical foods in the U.S. are regulated and developed for "rare disease or condition" (i.e. orphan disease), any disease or condition that occurs so infrequently in the United States that there is no reasonable expectation that a medical food for such disease or condition will be developed without assistance under subsection (a) of the "Grants for development of drugs for rare diseases and conditions" of the Orphan Drug Act (ODA), enacted by the U.S. Congress in January 1983. metabolic formula medical food medical foods medically necessary food medically necessary formula Metabolic formula is a nutritional formula that is a pharmaceutically developed food product (in the form of powder, pill or liquid) that is formulated to be consumed or administered enterally under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation. Curation status: Incomplete ONSTR:ONSTR_5020674 Definition source: ONSTR curators. blood amino-acid concentration measurement datum Blood amino-acid concentration measurement datum is a concentration measurement datum that provides the information about the quantity of an observed amino acid in the human blood eluate or blood plasma specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_5041330 Definition source: ONSTR curators. estimated average nutrient requirement for children age 1-to-3 years Estimated average nutrient requirement for children age 1-to-3 years is an estimated average nutrient requirement for children population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of children population 1 to 3 years of age. Curation status: Incomplete ONSTR:ONSTR_5058292 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.182-187. high average daily dietary vitamin B6 intake high mean vitamin B6 intake high vitamin B6 intake High average daily dietary vitamin B6 intake is an average daily dietary vitamin B6 intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary vitamin B6 for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5060782 Currently, most nutrient databases, as well as nutrition labels, do not distinguish among all the different forms of vitamin E found in food, and still use α-TE, thus including the contribution of all naturally occurring forms of vitamin E. Because the forms of vitamin E other than the naturally occurring form RRR-αtocopherol) do not occur in foods, the intake of α-TE is greater than the intake of α-tocopherol alone, and it is thus recommended that the use of α-TE be abandoned due to the lack of evidence of bioavailability via transport in the blood plasma or tissues. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) DRIs: The essential guide to nutrient requirements. The Insitute of medicine of the National academies. The National academies press, Washington DC, pp 236-237. ] Definition source: ONSTR curators. Three DRI values for vitamin E (the EAR, RDA and AI) apply only to intake of 2R-stereoisomeric forms of α-tocopherol from food, fortified foods and supplements. The other naturally occuring isomers of vitamin E (β-, γ- and δ-tocopherols and α-, β-, γ- and δ-tocotrienols) do not contribute to meeting the vitamin E requirements, because they are not converted to α-tocopherol in humans. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) DRIs: The essential guide to nutrient requirements. The Insitute of medicine of the National academies. The National academies press, Washington DC, pp 237. ] average daily dietary vitamin E intake during observed time interval mean vitamin E intake Average daily dietary vitamin E intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of vitamin E contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_5066707 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.262-269. low average daily dietary niacin intake low mean niacin intake low niacin intake Low average daily dietary niacin intake is an average daily dietary niacin intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary niacin for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5076673 Definition source: ONSTR curators. blood phenyalanine concentration therapeutic range datum Blood phenylalanine concentration therapeutic range datum is a blood amino-acid concentration therapeutic range datum that provides the information about the set of values of blood phenylalanine concentration measurements, such that the blood phenylalanine concentration values falling within this range do not produce or produce minimal toxic effects to most of the members of the observed population. Curation status: Incomplete ONSTR:ONSTR_5077448 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.280-285. low average daily dietary thiamine intake low mean thiamine intake low thiamine intake Low average daily dietary thiamine intake is an average daily dietary thiamine intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary thiamine for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5102144 Definition source: ONSTR curators. cerebrospinal fluid specimen creation objective Cerebrospinal fluid specimen creation objective is specimen creation objective to obtain a cerebrospinal fluid specimen from a human patient to use it as an input for further investigation. Curation status: Incomplete ONSTR:ONSTR_5107576 Definition source: http://en.wikipedia.org/wiki/Transthyretin To be replaced by the corresponding imported PRO class, if/when PRO asserts one. Transthyretin (transthyretin protein and transthyretin protein complex) has previously been called 'pre-albumin', because it ran faster than albumin on electrophoresis gels. [Source: http://en.wikipedia.org/wiki/Transthyretin ] transthyretin complex TTR TTR complex Transthyretin complex is a protein complex that is a homotetramer with dimer of dimers quaternary structure (each monomer being a single transthyretin protein). Transthyretin complex is sythetized in the liver, choroid plexus of brain ventricles and retinal pigment epithelium for secretion into the blood, cerebrospinal fluid and the eye, respectively. Curation status: Incomplete ONSTR:ONSTR_5112397 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 70-81. acceptable macronutrient distribution range for children population Acceptable macronutrient distribution range for children population is an acceptable macronutrient distribution range datum that is assumed to adequate for healthy children population 1 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_5115929 Definition source: ONSTR curators. percent recommended dietary calcium allowance Percent recommended dietary calcium allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary calcium consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for calcium. Curation status: Incomplete ONSTR:ONSTR_5125591 Definition source: ONSTR curators. adult parenteral trace element solution Adult trace element nutrient solution is a parenteral trace elements solution containing a combination of trace element micronutrients in various amounts, formulated for adults and children older than 11 years of age. Curation status: Incomplete Multitrace-5 ONSTR:ONSTR_5128731 Definition source: ONSTR curators. mass per unit time Mass per unit mass per unit time is a dietary nutrient intake per unit time that is a measure of the number of mass units of a given nutrient taken by a human in a given time interval. Curation status: Incomplete ONSTR:ONSTR_5139078 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.280-285. normal average daily dietary thiamine intake normal mean thiamine intake normal thiamine intake Normal average daily dietary thiamine intake is an average daily dietary thiamine intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary thiamine for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5141147 Definition source: ONSTR curators. estimated average nutrient requirement for female population Estimated average nutrient requirement for female population is an estimated average nutrient requirement for population age 9 years and older that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of female population of 9 years of age and older. Curation status: Incomplete ONSTR:ONSTR_5171079 Definition source: ONSTR curators consumed food item datum Consumed food item quantity datum is a food item datum providing the information about the name and the quantity of each particular food item consumed (ingested) by a human patient during the time interval relevant for dietary analysis. Curation status: Incomplete Apple juice 4 floz, strawberry 42 grams, gel cup 1 cup, hard candy 1 piece. ONSTR:ONSTR_5173920 Definition source: Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.65-67. Definition source: Physician's guide to the laboratory diagnosis of metabolic diseases. (2004) N. Blau, Duran, M. Blaskovics, M.E., Gibson, K.M. Eds. Springer Verlag, pp. 89. tetrahydrobiopterin deficiency BH4 deficiency BH4 (tetrahydrobiopterin) deficiency is a congenital metabolic disorder characterized by disruptions in BH4 biosythesis and regeneration cycle due to the mutated recessive alleles coding for one of the enzymes involved in BH4 biosythesis (GTP cyclohydrolase and 6-pyruvol-tetrahydrobiopterin-syntase), and/or mutated recessive alleles coding for enzymes involved BH4 regeneration (dihydropteridine reductase and pterin carbinolamine-4alpha-dehydratase). BH4 deficiencies have autosomal recessive inheritance pattern in both compound heterozygous (genetic compound) state and homozygous state. Curation status: Incomplete ONSTR:ONSTR_5174122 Definition source: ONSTR curators. adequate nutrient intake for female population age 14-to-18 years Adequate nutrient intake for female population age 14-to-18 years is an adequate nutrient intake for non-pregnant non-lactating female population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy female population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_5178796 Definition source: ONSTR curators. average daily dietary selenium intake during observed time interval average dietary Se intake daily dietary selenium intake daily selenium intake mean selenium intake Average daily dietary selenium intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary selenium contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_5190710 Definition source: ONSTR curators percent upper tolerable sodium intake level datum Percent upper tolerable sodium intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of sodium consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for sodium. Curation status: Incomplete ONSTR:ONSTR_5205203 Definition source: ONSTR curators Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf Following the recommendations given by The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children, blood specimen should be collected after after 24 hours post birth, but as close to discharge as possible. initial newborn dried blood spot screening process first DBS first newborn screen first screen initial DBS initial newborn screen initial screen Initial newborn dried blood spot screening process is a dried blood spot newborn screening proper process that is usually performed soon after the baby has been born, or between 48 and 72 hours of post birth and prior the newborn discharge from the hospital or at the other bitrhplace. Curation status: Incomplete ONSTR:ONSTR_5238894 Definition source: http://en.wikipedia.org/wiki/Effector_(biology) The role of enzyme effectors may be born by molecules that in the same biochemical reaction bear a enzyme substrate role, enzyme product role or enzyme cofactor role. enzyme effector role Enzyme effector role is a role of a chemical entity in a biochemical reaction that is born by a chemical entity that binds to the enzyme regulatory domain and that positively or negatively regulates the enzyme catalytic activity (i.e. activates or deactivates/inhibits the enzyme). Curation status: Incomplete ONSTR:ONSTR_5242351 Definition source: http://en.wikipedia.org/wiki/Pediatrics pediatrician role Pediatrician role is a physician role that is realized by a human during processes of providing health care to infants, children ands adolescents. Curation status: Incomplete. ONSTR:ONSTR_5243910 Definition source: ONSTR curators. average daily total dietary fat intake per body mass during observed time interval Average daily total dietary fat intake per body mass during observed time interval is an average daily dietary macronutrient intake per body mass during observed time interval denoting the average intake of fats contained in all nutritional items taken by a human patient during the observed time period with respect to patient's body mass. Curation status: Incomplete ONSTR:ONSTR_5252130 Definition source: ONSTR curators whole blood carnitine ester concentration measurement datum whole blood acyl-carnitine concentration Whole blood carnitine ester concentration measurement datum is a blood carnitine ester concentration measurement datum that provides the information about the quantity of a given carnitine ester in the human blood eluate or whole blood specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_5257504 Definition source: ONSTR curators. average daily dietary cholesterol intake during observed time interval Average daily dietary cholesterol intake over observed time interval datum is an average daily dietary macronutrient intake during observed time interval denoting the average quantity of dietary cholesterol contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days and/or three days). mean cholesterol intake Curation status: Incomplete ONSTR:ONSTR_5269916 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm birth-to-36 months length-for-age weight-for-age percentile chart infant length-for-age weight-for-age percentile chart length-for-age and weight-for-age percentile chart Birth-to-36 months height-for-age weight-for-age percentile chart is a height-for-age weight-for-age percentile chart that illustrates the distributions of height and weight measurement data with respect to age in a population of healthy infants 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_5274111 Definition source: ONSTR curators. recommended dietary allowance for female population Recommended dietary allowance for female population is a recommended dietary allowance for population age 9 years and older that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy female population age 9 years and older. Curation status: Incomplete ONSTR:ONSTR_5283753 An important principle underlying DRIs is that they are standards for apparently healthy people and are not meant to be applied to those with acute or chronic disease or for the repletion of nutrient levels in previously deficient individuals. Meeting the recommended intakes for the nutrients would not necessarily provide enough for individuals who are already malnourished, nor would they be adequate for certain disease states marked by increase nutrient requirements. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 13.] Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 6-12. Dietary reference intake is a system of nutrition recommendations designed by the Institute of Medicine of the U.S. National Academy of Sciences and is used both in the United States and in Canada for the general public and health professionals and applied in composition of diets for schools, hospitals, prisons or nursing homes, industrial development of new food stuffs and by healthcare policy makers and public health officials. [Source: http://en.wikipedia.org/wiki/Dietary_Reference_intake ] The Dietary Reference Intakes (DRIs) replace and expand the previous revisions of the RDAs (recommended daily allowances) and RNIs (recommended nutrient intakes) and represent a new approach to setting nutrient values by greatly expanding the scope and application of previous nutrient standards. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 17.] When assessing and planning diets, it is important to be mindful of the limitations in the data that underpin the DRIs and their application, which include the following: 1) The Estimated Average Requirements (EARs) may be based on data from limited number of individuals. 2) For most nutrients, the precise variation in requirements is not known but is approximated. 3) In the absence of evidence to the contrary, variation in individual requirements is assumed to follow a normal distribution. 4) The EAR is often extrapolated from one population group to another. 5) The degree of uncertainty associated with the EAR has not been specified. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 19.] Where data were available, DRIs were divided into 12 life stage groups and also by gender. The life stage groups were chosen by considering variations in the requirements of all of the nutrients under review. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 13.] dietary reference intake datum DRI DRIs dietary reference intake dietary reference intakes Dietary reference intake datum is a scalar measurement datum that is intended to be used as a recommended reference value for dietary nutrient and dietary energy intakes estimated to meet daily nutritional needs of different populations of healthy human individuals. Curation status: Incomplete ONSTR:ONSTR_5286290 Definition source: Kemp, D. F. (2002) Otoacoustic emissions, their origin in cochlear function, and use. British Medical Bulletin 2002;63: pp 223-241 In DPOAE test, non-linear intermodulation between two stimulus tones inside the cochlea generates several new acoustic frequency components, which can travel to the ear canal. Healthy ear canal distortion levels can be above 20 dB SPL (Sound Pressure Level). distortion product otoacoustic emissions test DPOAE recording DPOAE test Distortion product otoacoustic emissions test (DPOAEs test)is an otoacoustic emissions test with the objective to detect, record and measure the cochlear sound emissions in response to two stimulus tones of different frequencies released simultaneously into the ear canal. Curation status: Incomplete ONSTR:ONSTR_5288942 Definition source: ONSTR curators. nutritional item intake recording dietary intake recording feeding recording food intake recording Nutritional item intake recording is a planned process of obtaining information from a patient or patient's parent or caretaker about food items consumed (enterally or parenterally) by a patient within a specific time interval (last 24 hours, one day, two days, three days, seven days or thirty days). Curation status: Incomplete ONSTR:ONSTR_5299441 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.386-396. normal average daily dietary sodium intake normal mean natrium intake normal mean sodium intake normal natrium intake normal sodium intake Normal average daily dietary sodium intake is an average daily dietary sodium intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary sodium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5305807 Definition source: ONSTR curators. average daily dietary potassium intake per body mass during observed time interval Average daily dietary potassium intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary potassium contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5309155 Definition source: ONSTR curators dietary energy intake per unit time Dietary energy intake per unit time is a derived unit that is a measure of the number of dietary energy units (kilocalories) taken by a human in a give time interval, with or without respect to human body mass. Curation status: Incomplete ONSTR:ONSTR_5320178 Average dietary nutrient intake per body mass during observed time interval is a scalar calculated by dividing the average quantity of a given nutrient contained in all food items taken by a human patient during the observed time period by the number of kilograms of patient body mass. Definition source: ONSTR curators. average daily dietary nutrient intake per body mass during observed time interval datum Average daily dietary nutrient intake per body mass during observed time interval datum is an average daily dietary nutrient intake datum denoting the average quantity of relevant nutrient contained in all nutritional items taken by a human patient during the observed time period (one day, two days or three days) with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5334351 Definition source: Kemp, D. F. (2002) Otoacoustic emissions, their origin in cochlear function, and use. British Medical Bulletin 2002;63: pp 223-241 Definition source: http://en.wikipedia.org/wiki/Auditory_brainstem_response It is believed that auditory brain stem evoked potentials (waves 1 to 5, labeled commonly with Roman numerals) are generated by the following neurons of auditory pathway: Wave I by peripheral portion of vestibulocochlear nerve (cranial nerve VIII, CN8); Wave II, by central portion of vestibulocochlear nerve (cranial nerve VIII, CN8); Wave III, by cochlear nuclei of the brainstem; Wave IV, by lateral lemniscus and superior olive and Wave V, by lateral lemniscus and and superior colliculus. To interpret the ABR the following measurements are taken into account: the amplitude (the number of neurons firing), latency (the speed of transmission), interpeak latency (the time between peaks), and interaural latency (the difference in wave V latency between ears). The ABR represents initiated activity beginning at the base of the cochlea and moving toward the apex over a 4ms period of time. The ABR is used for newborn hearing screening, auditory threshold estimation, intraoperative monitoring, determining hearing loss type and degree, and auditory nerve and brainstem lesion detection.[Source: http://en.wikipedia.org/wiki/Auditory_brainstem_response ] Otoacoustic emission test (OAE) is usually done at birth, followed by an auditory brainstem response test, if the OAE test result indicate a possible hearing loss. As both tests ares sometimes performed routinely, some infant hearing screening equipment provides capability of running both tests by using one piece of equipment. [Source: http://deafness.about.com/cs/audiograms/a/abroae.htm ] Since auditory brainstem reposnse (ABR) is sensitive to both cochlear and retro-cochlear pathology, ABR testing would appear to be preferable to otoacoustic emissions (OAEs) for infant screening. However, in practice, sensory hearing impairment in the low-risk newborn population appears to be overwhelmingly of the sensory transmissive type, which is readily detectable by measurement of OAEs. [Source: Kemp, D. F. (2002) Otoacoustic emissions, their origin in cochlear function, and use. British Medical Bulletin 2002;63: pp 223-241. ] This may be moved under some other more appropriate mother class. auditory brainstem response test ABR recording ABR test with the objective to detect, record and measure the auditory evoked potential (AEP) generated by the neurons of the auditory pathway in the response to presented auditory stimulus. Auditory evoked potentials are recorded via electrodes placed on the scalp and extracted as a series of vertex positive potentials (waves), from the recording of the ongoing electromagnetic activity. Curation status: Incomplete ONSTR:ONSTR_5339171 Definition source: ONSTR curators percent adequate tyrosine intake datum Percent adequate tyrosine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid tyrosine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for tyrosine. Curation status: Incomplete ONSTR:ONSTR_5342809 Definition source: ONSTR curators. average daily dietary histidine intake per body mass during observed time interval Average daily histidine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino acid histidine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5349011 Definition source: http://www.cdc.gov/growthcharts/ To refer to the height quality of human body, in the case of neonates and infants word "length" is commonly used, while in children, adolescents and adults word "stature" has the same reference. In fact, all four language expressions "height", "body height", "length" and "stature" are commonly used in ambiguous manner to refer to both the quality of human body and to the measurement datum associated with that quality. height-for-age percentile chart height-for-age chart height-for-age percentile chart height-for-age percentiles height/stature-for-age percentile chart length-for-age percentile chart stature-for-age percentile chart Height-for-age percentile chart is a CDC individual growth chart consisting of smoothed percentile curves illustrating the distribution(s) of height measurement data (body height measurements) with respect to age in a population of healthy children of specific age group (e.g. birth to 36 months of age). Curation status: Incomplete ONSTR:ONSTR_5362990 Definition source: ONSTR curators. hepatocyte lacking phenylalanine-4-hydroxylase complex Hepatocyte lacking phenylalanine-4-hydroxylase complex is a disordered hepatocyte that due to alteration(s) in the PAH gene completely lacks the phenylalanine-4-hydroxylase protein and phenylalanine-4-hydroxylase complex. Curation status: Incomplete ONSTR:ONSTR_5363814 Definition source: http://en.wikipedia.org/wiki/Phenylalanine_hydroxylase normal phenylalanine-4-hyrdoxylase complex normal PAH normal PAH complex normal phenylalanine hyrdoxylase complex A phenyalalnine hydroxylase complex (phenyalalnine-4-hydroxylase dimer or tetramer complex) cosisiting of normal phenyalalnine-4-hydroxylase monomers. Curation status: Incomplete ONSTR:ONSTR_5378607 Definition source: ONSTR curators percent upper tolerable isoleucine intake level datum Percent upper tolerable isoleucine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid isoleucine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for isoleucine. Curation status: Incomplete ONSTR:ONSTR_5394856 Definition source: http://www.cdc.gov/growthcharts/charts.htm girls 2-to-5 years weight-for-stature percentile chart Weight-for-stature percentiles: Girls, 2 to 5 years girls weight-for-stature percentile chart girls weight-for-stature percentiles Girls 2-to-5 years weight-for-stature percentile chart is a 2-to-5 years weight-for-stature percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of weight measurement data (body mass measurements) with respect to height measurement data (body height measurements) in a population of healthy girls 2 to 5 years of age. Curation status: Incomplete ONSTR:ONSTR_5397567 Definition source: http://en.wikipedia.org/wiki/Neonatal_heel_prick Definition source: http://www.medterms.com/script/main/art.asp?articlekey=39542 neonatal heel-prick blood specimen collecting heel-prick heel-prick sampling heel-stick heel-stick (procedure) neonatal heel-prick sampling Neonatal heel-prick blood specimen collecting is capillary blood specimen collecting in which a small puncture is made by lancet in newborn's heel, after which emerged capillary blood is blotted onto the specially manufactured and labeled absorbent filter paper (also known and Guthrie card) and a dried blood spot specimen is been created. Curation status: Incomplete ONSTR:ONSTR_5413434 Definition source: http://en.wikipedia.org/wiki/Guthrie_test Definition source: http://www.pkutest.com/2012/07/20/guthrie-test-brought-pku-screening-every-hospital/ bacterial inhibition assay BIA Guthrie assay Guthrie bacterial inhibition assay Guthrie test PKU screen phenylalanine screen phenylketonuria screen phenylketonuria screen test Bacterial inhibition assay is an assay (a semiqunatitive assay) designed to detect the level of amino-acid phenylalanine in the dried blood spot specimen. A small disk (of standardized size) is punched from dried blood spot specimen and put on the agar gel plate that contains β-2-thyenilalanine that inhibits growth of Bacillus subtilis bacteria. In the presence of elevated levels of phenylalanine leached from the filter paper disk, inhibition of β-2-thyenilalanine is overcome and a bacterial colony grows surrounding the disk. Measured diameter of the colony is roughly proportional to the amount of phenylalanine in the blood. Guthrie test is sensitive enough to detect blood phenylalanine levels of 180-240 μmol/L (3-4 mg/dL) Curation status: Incomplete This calss may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ONSTR:ONSTR_5417525 Definition source: ONSTR curators percent upper tolerable micronutrient intake level datum Percent upper tolerable micronutrient intake level is a percent upper tolerable nutrient intake level datum that provides the information about the quantity of specific macronutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed micronutrient. Curation status: Incomplete ONSTR:ONSTR_5420157 Definition source: ONSTR curators. newborn screening program coordinator role Newborn screening program coordinator role is a health care provider role that is realized in during the processes of newborn short-term follow-up process by coordinating and overseeing the work of newborn screening program team members (usually newborn screening program nurses). Curation status: Incomplete. ONSTR:ONSTR_5429319 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.320-326. normal average daily dietary iodine intake normal iodine intake normal mean iodine intake Normal average daily dietary iodine intake is an average daily dietary iodine intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary iodine for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5443586 Definition source: ONSTR curators. average daily dietary vitamin C intake per body mass during observed time interval Average daily dietary vitamin C intake per body mass during observed time interval is an average vitamin intake per body mass during observed time interval information denoting the average quantity of vitamin C contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete 7.0 12.0 30.0 7.0 58.0 1.0 4.0 22.0 19.0 15.0 14.0 19.0 9.0 14.0 17.0 4.0 9.0 9.0 14.0 18.0 14.0 19.0 16.0 20.0 21.0 15.0 ONSTR:ONSTR_5466043 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. low average daily dietary intake per body mass of methionine and cysteine combined Low average daily dietary intake per body mass of methionine and cysteine combined is an average daily dietary intake per body mass of methionine and cysteine combined that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for dietary methionine and cysteine combined per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5471926 Definition source: ONSTR curators. average daily dietary lysine intake during observed time interval average daily dietary Lys intake daily Lys intake mean lysine intake Average daily lysine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid lysine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_5474499 Definition source: ONSTR curators percent estimated average biotin requirement datum Percent estimated average biotin requirement is a percent estimated average vitamin requirement that provides the information about the quantity of biotin consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for biotin. Curation status: Incomplete ONSTR:ONSTR_5475171 Definition source: ONSTR curators. percent recommended dietary chromium allowance Percent recommended dietary chromium allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary chromium consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for chromium. Curation status: Incomplete ONSTR:ONSTR_5489310 Definition source: ONSTR curators percent estimated average histidine requirement datum Percent estimated average histidine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid histidine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for histidine. Curation status: Incomplete ONSTR:ONSTR_5490636 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 boys 2-to-20-years stature-for-age percentile chart Height-for-age percentiles: Boys, 2 to 20 years Stature-for-age percentiles: Boys, 2 to 20 years boys height-for-age 2 to 20 years percentile chart boys stature-for-age 2 to 20 years percentile chart Boys 2-to-20-years stature-for-age percentile chart is a 2-to-20-years stature-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of height measurement data (body height measurements) with respect to age in a population of healthy boys 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_5491871 Definition source: ONSTR curators. average daily dietary selenium intake per body mass during observed time interval Average daily dietary selenium intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary selenium contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5493677 Definition source: ONSTR curators. tolerable nutrient intake range datum Tolerable nutrient intake range is a range datum that provides the information about the set of values of daily intake of a particular nutrient (quantity), such that the intake of that nutrient results in concentrations of the nutrient in bodily fluids (usually blood) that fall within therapeutic range for that particular nutrient. Curation status: Incomplete ONSTR:ONSTR_5495478 Definition source: ONSTR curators percent estimated average micronutrient requirement datum Percent estimated average micronutrient requirement is a percent estimated average requirement datum that provides the information about the quantity of specific macronutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for the observed micronutrient. Curation status: Incomplete ONSTR:ONSTR_5501278 Definition source: ONSTR curators. percent recommended dietary vitamin E allowance Percent recommended dietary vitamin E allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary vitamin E consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for vitamin E. Curation status: Incomplete ONSTR:ONSTR_5512104 Definition source: ONSTR curators. blood plasma tryptophan concentration measurement datum plasma Trp plasma Trp level plasma Trp status plasma tryptophan concentration plasma tryptophan level plasma tryptophan measurement plasma tryptophan status Blood plasma tryptophan concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid tryptophan in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_5527326 Definition source: ONSTR curators percent adequate tryptophan intake datum Percent adequate tryptophan intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid tryptophan consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for tryptophan. Curation status: Incomplete ONSTR:ONSTR_5527596 Definition source: http://en.wikipedia.org/wiki/Primary_care_physician primary care physician role PCP role Primary care physician role is a physician role that is realized in processes of providing first contact care for a person with an undiagnosed health concern as well as continuing care of various medical conditions. Curation status: Incomplete. ONSTR:ONSTR_5540226 Definition source: 2000 CDC Growth Charts for the United States: Methods and development, Vital and Health Statistics, Series 11, No 246, Department of Health and Human Services, CDC National Center for Health Statistics, Hyattsville, MD, May 2002, pp 1. Definition source: http://www.cdc.gov/growthcharts/who_charts.htm U.S. Center for Disease Control and Prevention (CDC) recommends that health care providers use the WHO growth standards (WHO growth charts) to monitor growth for infants and children ages 0 to 2 years of age, while CDC growth charts should be used for monitoring growth of children age 2 years and older. [Source: http://www.cdc.gov/growthcharts/who_charts.htm] Unlike WHO growth standards charts which were constructed using longitudinal length and weight data measured at frequent intervals, for CDC growth charts, weight data were not available between birth and 3 months of age, and the sample sizes were small for sex and age groups during the first 6 months of age. For this reason CDC growth charts should be only used as references and not as a sole diagnostic tool. [Source: http://www.cdc.gov/growthcharts/who_charts.htm] CDC growth chart Center for Disease Control and Prevention growth chart growth chart CDC growth chart is a developmental growth chart that is based on typical growth patterns of children in the U.S. during a specific period of childern's life time, published by the CDC in May 2000 and designed for use in the United States. The 2000 CDC growth charts are available in two formats, as individual charts (i.e. CDC individual growth chart) and clinical charts (i.e. CDC clinical chart). Curation status: Incomplete ONSTR:ONSTR_5541529 Definition source: ONSTR curators. average daily dietary glycine intake per body mass during observed time interval Average daily glycine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid glycine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5543067 Definition source: http://www.cdc.gov/growthcharts/charts.htm birth-to-36 months weight-for-length percentile chart infant weight-for-length percentile chart weight-for-length chart weight-for-length percentile chart weight-for-length/height percentile chart Birth-to-36 months weight-for-length percentile chart is a weight-for-height percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of weight measurement data (body mass measurements) with respect to height measurement data (body height measurements) in a population of healthy children 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_5544961 Definition source: ONSTR curators. newborn screening program nurse role Newborn screening program nurse role is a nurse role that is realized during processes of newborn dried blood spot screenig short-term follow-up (e.g. identifying and locating the infant screened positive for an inherited metabolic disease (IMD), contacting infant's primary care physician and family, referring to specialist, analyzing the newborn screening test results, in some IMDs cases recommending the therapy initiation etc.). Curation status: Incomplete. ONSTR:ONSTR_5569911 Definition source: http://www.cdc.gov/ncbddd/hearingloss/screening.html Definition source: http://www.nidcd.nih.gov/health/hearing/pages/screened.aspx newborn hearing screening process Newborn hearing screening process is a point-of-care newborn screening proper process that includes otoacustic emissions test and auditory brain stem response test and that is usually done before a newborn has been discharged from a birthing center or hospital (but no later that 3 moths of age), with a goal to timely detect potential hearing function loss that would cause delay or prevent normal linguistic (speech) development. Curation status: Incomplete ONSTR:ONSTR_5580928 Definition source: Hinman, A.R., Mann, M.Y., Singh, R.H. (2009) Newborn dried bloodspot screening: mapping the clinical and public health components and activities. Genetics in Medicine, Vol.11, No. 6, June 2009. newborn dried blood spot screening proper process NDBS newborn dried blood spot screening Newborn dried blood spot screening proper process is a newborn screening proper process that includes the processes of collecting a heel stick blood sample onto a filter paper (usually in first 48 hours post birth), analyzing the collected dried blood spot specimen using state approved laboratory methods and reporting results to the state, health care providers and family. Curation status: Incomplete ONSTR:ONSTR_5580969 Definition source: ONSTR curators percent adequate sodium intake datum Percent adequate sodium intake is a percent adequate dietary mineral intake that provides the information about the quantity sodium consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for sodium. Curation status: Incomplete ONSTR:ONSTR_5583212 Definition source: Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.62. normal phenylalanine hydroxylase genotype normal phenylalanine hydroxylase genotype A PAH genotype that includes two normal alleles (non-mutated alleles, wild type alleles) each coding for enzyme phenylalanine hydroxylase monomer (PAH monomer), having gene map locus 12q22-q24.2 (on homologous chromosome 12). Curation status: Incomplete ONSTR:ONSTR_5585204 Definition source: Whitney, E. N., Rolfes, S.H. (2012) Understanding nutrition 13th Ed. Wadsworth, Cengage Learning. dietitian role Dietitian role is a health care provider role that is realized by a human trained in science of nutrition who passed the professional registration exam, and during the nutrition care processes (nutrition status assessment, nutrition diagnosing, nutrition therapy evaluation and adjustment etc.) Curation status: Incomplete. ONSTR:ONSTR_5595149 Definition source: ONSTR curators. confirmatory diagnosis for phenylalanine hydroxylase deficiency Confirmatory diagnosis for phenylalanine hydroxylase deficiency is a confirmatory diagnosis for a disease indicated by positive newborn dried blood spot screening finding that is provides the information about laboratory and genetic test results and physiological tests leading to the conclusion that the patient without doubt has phenylalanine hydroxylase deficiency. Curation status: Incomplete ONSTR:ONSTR_5602197 Definition source: ONSTR curators. average daily dietary tyrosine intake per body mass during observed time interval Average daily tyrosine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of a amino-acid tyrosine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5604042 Definition source: ONSTR curators. estimated average nutrient requirement for non-pregnant non-lactating female population Estimated average nutrient requirement for non-pregnant non-lactating female population is an estimated average nutrient requirement for female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of healthy non-pregnant non-lactating female population. Curation status: Incomplete ONSTR:ONSTR_5618701 Definition source: ONSTR curators. disease specific confirmatory test Disease specific confirmatory test is an assay that has specified output providing an information based on which the presence or absence of a particular disease can be determined with relatively high degree of reliability. Curation status: Incomplete ONSTR:ONSTR_5619441 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp.350-355. low average daily dietary manganese intake low manganese intake low mean manganese intake Low average daily dietary manganese intake is an average daily dietary manganese intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary manganese for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5644811 Definition source: ONSTR curators. blood phenylalanine concentration finding Blood phenylalanine concentration finding is a phenylalanine concentration finding that is based on the value of blood phenylalanine concentration measurement datum or plasma phenylalanine concentration measurement datum, and that is based blood phenyalanine concentration reference value ranges established through clinical research. Curation status: Incomplete ONSTR:ONSTR_5646467 Definition source: ONSTR curators. head circumference at long-term follow-up visit measurement datum Head circumference at long-term follow-up visit measurement datum is a head circumference measurement datum that is the result of the head circumference measurement assay during physical examination at each scheduled patient follow-up visit. Curation status: Incomplete ONSTR:ONSTR_5648384 Definition source: ONSTR curators percent upper tolerable cysteine intake level datum Percent upper tolerable cysteine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid cysteine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for cysteine. Curation status: Incomplete ONSTR:ONSTR_5654422 Definition source: ONSTR curators. percent recommended dietary zinc allowance Percent recommended dietary zinc allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary zinc consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for zinc. Curation status: Incomplete ONSTR:ONSTR_5654570 Definition source: ONSTR curators. blood plasma arginine concentration measurement datum plasma Arg plasma Arg level plasma Arg status plasma arginine concentration plasma arginine measurement plasma arginine status Blood plasma arginine concentration measurement datum is a blood plasma amino acid concentration measurement datum that provides the information about the quantity of amino acid arginine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_5656935 Definition source: ONSTR curators. adequate nutrient intake male population age 51-to-70 years Adequate nutrient intake for male population age 51-to-70 years is an adequate nutrient intake for male population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy male population 51 to 70 years of age. Curation status: Incomplete ONSTR:ONSTR_5663159 Definition source: ONSTR curators percent upper tolerable aspartic acid intake level datum Percent upper tolerable aspartic acid intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of aspartic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for aspartic acid. Curation status: Incomplete ONSTR:ONSTR_5666197 Definition source: ONSTR curators. adequate nutrient intake for infant population Adequate nutrient intake for infant population is an adequate nutrient intake for population age 0-to-8 years that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy infant population. Curation status: Incomplete ONSTR:ONSTR_5692828 Definition source: ONSTR curators. Definition source: http://fda.gov/Food/DietarySupplements/ConsumerInformation/ucm110417.htm Definition source: http://ods.od.nih.gov/factsheets/DietarySupplements/#3 nutritional item Nutritional item is an object that contains nutrients and may contain non-dietary ingredients (fillers, artificial colors, sweeteners, flavors or binders) and that is administered into the organism enterally or parenterally. Curation status: Incomplete ONSTR:ONSTR_5693272 Definition source: ONSTR curators percent adequate docosahexaenoic acid intake datum Percent adequate docosahexaenoic acid intake is a percent adequate fatty acid intake that provides the information about the quantity of docosahexaenoic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for docosahexaenoic acid. Curation status: Incomplete ONSTR:ONSTR_5697260 Definition source: ONSTR curators. average daily dietary vitamin B6 intake per body mass during observed time interval Average daily dietary vitamin B6 intake per body mass during observed time interval is an average daily dietary vitamin B6 intake per body mass during observed time interval information denoting the average quantity of vitamin B6 contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5701447 Definition source: ONSTR curators percent upper tolerable lysine intake level datum Percent upper tolerable lysine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid lysine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for lysine. Curation status: Incomplete 0.35 0.67 ONSTR:ONSTR_5710612 Definition source: ONSTR curators. NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. non-critical positive newborn dried blood spot screening finding for medium-chain acyl-coenzyme A dehydrogenase deficiency for infants with body mass at birth greater than 2500 grams non-critical NDBS screen for MCADD non-critical newborn screen for medium-chin co-enzyme A dehydrogenase deficiency non-critical screen for MCADD Non-critical positive dried blood spot screening finding for medium-chin co-enzyme A dehydrogenase deficiency is a positive newborn dried blood spot screening finding for medium-chain acyl-coenzyme A dehydrogenase deficiency that is based on abnormally high whole blood octanoylcarnitine concentration in 0.35-0.67 μM range and abnormally high ratio between acetylcarnitine and octanoylcarnitine concentration (greater than 0.025), while the concentrations of relevant blood amino acids, carnitine, and other carnitine esters, and relevant concentration ratios fall within the laboratory established normal ranges.This type of positive newborn dried blood spot screening finding for medium-chin co-enzyme A dehydrogenase deficiency does not requires immediate medical attention and/or intervention and treatment initiation. Curation status: Incomplete ONSTR:ONSTR_5716374 Definition source: ONSTR curators. average daily dietary glutamine intake per body mass during observed time interval Average daily glutamine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid glutamine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5725405 Definition source: ONSTR curators. average daily dietary glutamic acid intake during observed time interval average daily dietary Glu intake daily Glu intake Average daily glutamic acid intake during observed time interval is an average daily amino-acid intake during observed time interval denoting the average quantity of glutamic acid contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_5738407 Definition source: ONSTR curators percent adequate cysteine intake datum Percent adequate cysteine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid cysteine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for cysteine. Curation status: Incomplete ONSTR:ONSTR_5740574 Definition source: ONSTR curators percent upper tolerable chromium intake level datum Percent upper tolerable chromium intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of chromium consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for chromium. Curation status: Incomplete ONSTR:ONSTR_5743236 Definition source: ONSTR curators. upper tolerable nutrient intake level for pregnant female population age 14-to-18 years Upper tolerable nutrient intake level for pregnant female population age 14-to-18 years is an upper tolerable nutrient intake level for pregnant female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy pregnant female population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_5746049 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 111-121. normal average daily total dietary fiber intake normal daily fiber intake normal fiber intake normal mean fiber intake Normal average daily dietary fiber intake is an average daily total dietary fiber intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for total dietary fiber for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5758799 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.320-326. high average daily dietary iodine intake high iodine intake high mean iodine intake High average daily dietary iodine intake is an average daily dietary iodine intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary iodine for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5763854 Definition source: ONSTR curators. nutrient intake analysis objective Nutrient intake analysis objective is objective specification where the goal of nutrient analysis is determination of quantities of nutrients contained in particular food item(s) been consumed and their energy value. Curation status: Incomplete ONSTR:ONSTR_5773210 Definition source: ONSTR curators. phenotypic sex categorical datum phenotypical sex datum Phenotypic sex categorical datum is a data item that provides information about the phenotypical sex quality of a human patient. Curation status: Incomplete ONSTR:ONSTR_5777623 Definition source: ONSTR curators. newborn screening finding for critical congenital heart disease Newborn screening finding for critical congenital heart disease is a newborn screening finding that is the output of interpretation of newborn pulse oximetry test result and that provides the information about the presence or absence of critical congenital heart disease (CCHD). Curation status: Incomplete ONSTR:ONSTR_5777686 Definition source: ONSTR curators percent estimated average alanine requirement datum Percent estimated average alanine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid alanine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for alanine. Curation status: Incomplete ONSTR:ONSTR_5782884 Definition source: ONSTR curators. age at research study visit measurement datum age at research visit Age at research study visit measurement datum is a age since birth measurement datum that is the result of measurement of the amount of time a human research study participant has been living until the day of the particular research study visit. Curation status: Incomplete ONSTR:ONSTR_5789148 Definition source: ONSTR curators percent upper tolerable choline intake level datum Percent upper tolerable choline intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of choline consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for choline. Curation status: Incomplete ONSTR:ONSTR_5790426 Definition source: ONSTR curators percent adequate histidine intake datum Percent adequate histidine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid histidine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for histidine. Curation status: Incomplete ONSTR:ONSTR_5808533 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. normal average daily dietary histidine intake normal histidine intake normal mean histidine intake Normal average daily dietary histidine intake is an average daily dietary histidine intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary histidine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5815166 Definition source: http://fda.gov/Food/DietarySupplements/ConsumerInformation/ucm110417.htm Definition source: http://ods.od.nih.gov/factsheets/DietarySupplements-HealthProfessional/ Dietary supplement are regulated by the U.S. Food and Drug Administration (FDA) as foods, but regulated differently from other foods and from drugs (medications). Whether a product is classified as a dietary supplement, conventional food or drug (medication) is based on its intended use. Most often, classification as a dietary supplement is determined by the information that the manufacturer provides on the product label or in accompanying literature, although many food and dietary supplement product labels do not include this information. [Source: http://ods.od.nih.gov/factsheets/DietarySupplements-HealthProfessional/ ] The U.S. Congress defined "dietary supplement" in the Dietary Supplement Health and Education Act (DSHEA) of 1994, as a product taken by mouth that contains "dietary ingredient" intended to supplement the diet. The "dietary ingredients" contained in "dietary supplements" may include: vitamins, dietary minerals, herbs, botanicals, amino-acids and substances such as enzymes, organ tissues, glandulars, metabolites and extracts or concentrates. Regardless of their form (pill, capsule, caplique, softgel, gelcap, tablet, liquid, powder or bar), DSHEA places dietary supplements in a special category under general umbrella of "foods", not drugs (medications), and requires that every supplement be labeled as a dietary supplement. [Source: http://fda.gov/Food/DietarySupplements/ConsumerInformation/ucm110417.htm dietary supplement Dietary supplement is a nutritional item that is a industrial product that is intended to supplement the regular diet, contains one or more dietary nutrients or herbs or botanicals, is taken enterally in the form of a pill, capsule, caplique, softgel, gelcap, tablet, liquid or powder, and that is labeled by the manufacturer as being dietary supplement. Curation status: Incomplete 7.0 12.0 30.0 43.0 7.0 58.0 59.0 1.0 4.0 22.0 28.0 19.0 15.0 19.0 14.0 19.0 9.0 14.0 17.0 21.0 4.0 9.0 9.0 14.0 18.0 22.0 14.0 19.0 16.0 19.0 20.0 25.0 21.0 26.0 15.0 ONSTR:ONSTR_5818005 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. normal average daily dietary intake per body mass of methionine and cysteine combined Normal average daily dietary intake per body mass of methionine and cysteine combined is an average daily dietary intake per body mass of methionine and cysteine combined that has the value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) for dietary methionine and cysteine combined per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5821678 Definition source: ONSTR curators. whole blood isoleucine concentration measurement datum blood Ile concentration blood Ile level blood Ile status blood isoleucine concentration blood isoleucine level blood isoleucine measurement blood isoleucine status Whole blood isoleucine concentration measurement datum is a whole blood amino-acid concentration measurement datum that provides the information about the quantity of amino-acid isoleucine in the human blood specimen (or blood eluate derived from the dried blood spot specimen) that has been collected from patient at least 2.5 or 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_5827536 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.170-181. normal average daily dietary vitamin A intake normal mean vitamin A intake normal vitamin A intake Normal average daily dietary vitamin A intake is an average daily dietary vitamin A intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary vitamin A for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5837093 Definition source: ONSTR curators. 24-hour recall nutritional item intake record 24-h recall 24-hour recall 24-hour recall food intake 24-hour recall intake record 24-hour recall record 24-hour recall nutritional item intake record is a nutritional item intake record completed by a patient, patient's parent or caretaker or dietitian, and that contains the information about the types and quantites of consumed food items, nutritional supplements, medical foods and food amino-acid excahnges a patient or patient's parent can recall the patient has consumed in the last 24 hours prior to the follow-up visit. Curation status: Incomplete ONSTR:ONSTR_5858734 Definition source: ONSTR curators. average daily dietary eicosapentaenoic acid intake per body mass during observed time interval average daily EPA intake per body mass daily EPA intake per body mass Average daily dietary eicosapentaenoic acid intake per body mass during observed time interval is an average daily dietary fatty acid intake per body mass during observed time interval denoting the average quantity of dietary eicosapentaenoic acid (EPA) contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5864087 Definition source: http://fnic/nal/usda.gov estimated dietary energy requirement datum EER RDI-EER dietary reference intake-estimated energy requirement estimated energy requirement Estimated dietary energy requirement datum is a scalar measurement datum denoting the average amount of dietary energy intake that is predicted to maintain energy balance in a healthy human adult of a specific age, gender, weight, height, and level of physical activity consistent with good health. Curation status: Incomplete ONSTR:ONSTR_5873093 Definition source: ONSTR curators. average daily dietary magnesium intake per body mass during observed time interval Average daily dietary magnesium intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary magnesium contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_5874537 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 111-121. high average daily total dietary fiber intake high daily fiber intake high fiber intake high mean fiber intake High average daily dietary fiber intake is an average daily total dietary fiber intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for total dietary fiber for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5875975 Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesauarus.owl#Body_Mass_Index Definition source: http://purl.bioontology.org/ontology/MSH/D015992 body mass index BMI BODY MASS INDEX Body Mass Index Index, Body Mass Index, Quietelet Quietelet Index Quietelet index Quietelet's index body mass index (BMI) Body mass index is a data item that is used as general indicator of body density or the amount of fat contained on human body. Curation status: Incomplete ONSTR:ONSTR_5880634 Definition source: ONSTR curators. domestically processed food item Domestically processed food item is a processed food item that has been created at a human household by thermal or other kind of processing (e.g. pickling, smoke drying, marinating) for purposes of immediate or later consumption. Curation status: Incomplete Home made soup, beat salad, home pickled cabbage. ONSTR:ONSTR_5883438 Definition source: http://www.nutritionalanalysissoftware.com Originally, method of nutritional analysis was performed in a laboratory where a chemical process was used to establish the nutritional value. Software analysis is based on sets of previously laboratory analyzed food samples, while more advanced form of this analysis is done through a web application. [Source: http://www.nutritionalanalysissoftware.com] nutrient analysis software dietary analysis software nutrition analysis software Nutrient analysis software is a software application that performs nutrition analysis of food item(s) been taken or used as a recipe ingredients, and that provides information about nutrient content and energy value(s) of analyzed food items as the output of the nutrient analysis. Curation status: Incomplete ONSTR:ONSTR_5887833 Definition source: http://www.cdc.gov/growthcharts/charts.htm 2-to-5 years weight-for-stature percentile chart preschoolers weight-for-stature percentile chart weight-for-stature chart weight-for-stature percentile chart 2-to-5 years weight-for-stature percentile chart is a weight-for-height percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of weight measurement data (body mass measurements) with respect to height measurement data (body height measurements) in a population of healthy children 2 to 5 years of age. Curation status: Incomplete ONSTR:ONSTR_5904651 Definition source: Academy of Nutrition and Dietetics (2013) International Dietetics and Nutrition Terminology (IDNT) Reference Manual. Standardized Language for the Nutrition Care Process. 4th Ed. Academy of Nutrition and Dietetics, Chicago, IL, pp. 19-33. nutrition assessment nutrition status assessment Nutrition assessment is a health care process that realizes dietitian role and patient role and that is a collection of processes of obtaining, verifying and interpreting the data needed for establishing a nutrition diagnosis. Curation status: Incomplete ONSTR:ONSTR_5915536 Definition source: ONSTR curators. average daily dietary aspartic acid intake during observed time interval average daily dietary Asp intake daily Asp intake Average daily aspartic acid intake during observed time interval is an average daily amino-acid intake during observed time interval denoting the average quantity of aspartic acid contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_5929460 Definition source: ONSTR curators percent adequate nickel intake datum Percent adequate nickel intake is a percent adequate dietary mineral intake that provides the information about the quantity nickel consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for nickel. Curation status: Incomplete ONSTR:ONSTR_5932346 Definition source: ONSTR curators. blood plasma aspartic acid concentration measurement datum plasma Asp plasma Asp level plasma aspartic acid concentration plasma aspartic acid measurement plasma aspartic acid status Blood plasma aspartic acid concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of aspartic acid in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_5941530 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.170-181. high average daily dietary vitamin A intake high mean vitamin A intake high vitamin A intake High average daily dietary vitamin A intake is an average daily dietary vitamin A intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary vitamin A for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5951138 Definition source: Academy of Nutrition and Dietetics (2013) International Dietetics and Nutrition Terminology (IDNT) Reference Manual. Standardized Language for the Nutrition Care Process. 4th Ed. Academy of Nutrition and Dietetics, Chicago, IL, pp. 9-16. nutrition care process NCP Nutrition care process is a health care process that realizes dietitian role and patient role and that is a collection of processes designed to improve consistency and quality of personalized nutrition treatment and the predictability of patient's outcome. Curation status: Incomplete ONSTR:ONSTR_5956458 Definition source: ONSTR curators percent adequate vitamin A intake datum Percent adequate vitamin A intake is a percent adequate vitamin intake that provides the information about the quantity of vitamin A consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for vitamin A. Curation status: Incomplete ONSTR:ONSTR_5965017 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.244-253. low average daily dietary folacin intake low folacin intake low folate intake low folic acid intake low mean folate intake Low average daily dietary folacin intake is an average daily dietary folacin intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary folacin (folate) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5970451 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. 2006. Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds. The National academies press, Washington DC., pp. 6-12. When assessing and planning diets, it is important to be mindful of the limitations in the data that underpin the DRIs and their application, which include the following: 1) The Estimated Average Requirements (EARs) may be based on data from limited number of individuals. 2) For most nutrients, the precise variation in requirements is not known but is approximated. 3) In the absence of evidence to the contrary, variation in individual requirements is assumed to follow a normal distribution. 4) The EAR is often extrapolated from one population group to another. 5) The degree of uncertainty associated with the EAR has not been specified. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 19.] estimated average nutrient requirement datum DRI-EAR EAR EARs dietary reference intake-estimated average requirement estimated average requirement estimated average requirements Estimated average nutrient requirement datum is a dietary nutrient reference intake datum that denotes the quantity of a dietary nutrient estimated (expected) to satisfy the nutritional requirements for that particular nutrient, of 50% of all members of an healthy human population determined based on age, gender and gender specific physiological status of being pregnant or lactating. Curation status: Incomplete ONSTR:ONSTR_5975394 Definition source: ONSTR curators percent estimated average phosphorus requirement datum Percent estimated average phosphorus requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of phosphorus consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for phosphorus. Curation status: Incomplete ONSTR:ONSTR_5977484 Definition source: ONSTR curators. percent recommended dietary aspartic acid allowance Percent recommended dietary aspartic acid allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary aspartic acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for aspartic acid. Curation status: Incomplete ONSTR:ONSTR_5978745 Definition source: ONSTR curators. percent recommended dietary lysine allowance Percent recommended dietary lysine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary lysine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid lysine. Curation status: Incomplete ONSTR:ONSTR_5980902 Definition source: ONSTR curators percent adequate protein intake datum Percent adequate protein intake is a percent adequate macronutrient intake that provides the information about the total quantity of all proteins combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for (total) protein. Curation status: Incomplete ONSTR:ONSTR_5983012 Definition source: ONSTR curators. percent recommended dietary molybdenum allowance Percent recommended dietary molybdenum allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary molybdenum consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for molybdenum. Curation status: Incomplete ONSTR:ONSTR_5985064 Definition source: ONSTR curators. percent recommended dietary arginine allowance Percent recommended dietary arginine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary arginine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid arginine. Curation status: Incomplete ONSTR:ONSTR_5985880 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.380-384. low average daily dietary selenium intake low mean selenium intake low selenium intake Low average daily dietary selenium intake is an average daily dietary selenium intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary selenium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_5994959 Definition source: Charney, P., Malone, A. Eds. (2004) ADA pocket guide to nutrition assessment. American Dietetic Association, pp. 33-39. nutritional item intake diary food diary food intake diary food intake record food record Nutritional item intake diary is a nutritional item intake record that contains the information about the types and quantities of nutritional items taken by a patient (enterally or pareneterally) during a period of time relevant to nutrition assessment (one, two, three or seven days). Curation status: Incomplete ONSTR:ONSTR_5995471 Definition source: ONSTR curators. blood plasma serine concentration measurement datum plasma Ser plasma Ser level plasma Ser status plasma serine concentration plasma serine measurement plasma serine status Blood plasma serine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid serine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_6008758 Definition source: ONSTR curators. Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Meal meal Meal is a collection of food items (consisting of at least one food item) ingested by an organism that occurs by custom or habit at more or less fixed times of the day. The amount and type of food items largely depends on personal and cultural customs and habits and varies over a lifetime. Curation status: Incomplete ONSTR:ONSTR_6012755 Definition source: ONSTR curators percent adequate isoleucine intake datum Percent adequate isoleucine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid isoleucine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for isoleucine. Curation status: Incomplete ONSTR:ONSTR_6015466 Definition source: ONSTR curators. average daily dietary chromium intake during observed time interval average Cr intake daily chromium intake mean chromium intake Average daily dietary chromium intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary chromium contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_6025078 Definition source: ONSTR curators percent upper tolerable carbohydrate intake level datum Percent upper tolerable carbohydrate intake level is a percent upper tolerable macronutrient intake level that provides the information about the total quantity of all carbohydrates combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for (total) carbohydrate. Curation status: Incomplete ONSTR:ONSTR_6032935 Definition source: Implementing Newborn Point-of-Care Newborn Screening - HRSA Report available for retrieval at http://www.hrsa.gov/advisorycommittees/mchbadvisoryheritabledisorders/recommendations/correspondence/implementpocnewbornscreen.pdf point-of-care newborn screening proper process POS-NBS Point-of-care newborn screening proper process is a newborn screening proper process that includes medical practices and physiologic tests that are administered and that produce actionable results at the bedside (outside of a laboratory), close to the site of delivery of medical care for a newborn (i.e. birth hospital or nursery). Curation status: Incomplete ONSTR:ONSTR_6033064 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.234-243. high average daily dietary vitamin K intake high mean vitamin K intake high vitamin K intake High average daily dietary vitamin K intake is an average daily dietary vitamin K intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary vitamin K for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6059681 Definition source: ONSTR curators. average daily dietary niacin intake per body mass during observed time interval Average daily dietary niacin intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of niacin contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_6062494 Definition source: ONSTR curators. percent recommended dietary threonine allowance Percent recommended dietary threonine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary threonine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid threonine. Curation status: Incomplete ONSTR:ONSTR_6066538 Definition source: ONSTR curators. weight-for-age percentile derivation Weight-for-age percentile derivation is developmental growth indicator derivation with the goal to determine (or give best possible approximation of) weight-for-age percentile for given child at the time of physical examination. In order to derive weight-for-age percentile information about child's body height and age are first plotted with respect to the height and age scales of the age and sex appropriate weight-for-age growth chart; the position of the resulting point is then compared with respect to weight-for-age percentile curves comprising weight-for-age growth chart; weight-for-age percentile is then determined (or maximally approximated) based on the closest percentile curve. Curation status: Incomplete 2.0 10.0 120.0 360.0 ONSTR:ONSTR_6067230 Definition source: ONSTR curators. non-PKU hyperphenylalaninemia finding Non-PKU hyperphenylalaninemia finding is a hyperphenylalaninemia finding based on the value of blood phenylalanine concentration measurement datum or plasma phenylalanine concentration measurement datum falling within the range of 120 - 360 μmol/L (or 2 - 10 mg/dL) that is not considered as indicative of phenylketonuria (PKU). Curation status: Incomplete ONSTR:ONSTR_6070889 Definition source: ONSTR curators. percent recommended dietary asparagine allowance Percent recommended dietary asparagine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary asparagine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid asparagine. Curation status: Incomplete ONSTR:ONSTR_6077676 Definition source: ONSTR curators. percent recommended dietary vitamin K allowance Percent recommended dietary vitamin K allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary vitamin K consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for vitamin K. Curation status: Incomplete ONSTR:ONSTR_6081701 Definition source: ONSTR curators. average daily dietary vitamin A intake during observed time interval daily retinol intake daily vitamin A intake mean vitamin A intake Average daily dietary vitamin A intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of vitamin A contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_6083248 Definition source: ONSTR curators percent adequate selenium intake datum Percent adequate selenium intake is a percent adequate dietary mineral intake that provides the information about the quantity selenium consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for selenium. Curation status: Incomplete ONSTR:ONSTR_6093772 Definition source: ONSTR curators. data collection Data collection is an information content entity that is an aggregate of data items that could be grouped into data sets or groups of data items of different types that all have something in common. Curation status: Incomplete A patient record or a research study participant record consisting of various types of data all pertaining to the particular patient or research study participant that may include, full blood count data, complete metabolic panel, dietary intake data, anthropometrics, person demographics etc. ONSTR:ONSTR_6096886 Definition source: http://www.cdc.gov/growthcharts/charts.htm girls head circumference-for-age percentile chart Head circumference-for-age percentiles: Girls, birth to 36 months girls head circumference-for-age percentile chart girls head circumference-for-age percentiles Girls head circumference-for-age percentile chart is a head circumference-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of head circumference measurement data (head circumference measurements) with respect to age in a population of healthy girls 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_6097970 Definition source: ONSTR curators. average daily dietary valine intake per body mass during observed time interval Average daily valine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid valine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_6108759 Definition source: ONSTR curators. tolerable tyrosine intake datum Tyr tolerance tyrosine intake tolerance tyrosine tolerance Tolerable tyrosine intake datum is a tolerable amino-acid intake datum that provides the information about quantity of tyrosine that a patient can consume enterally or parenterally during the 24 hours time interval, such that the value of the concentration of tyrosine in the blood measured after the observed 24 hours falls within the therapeutic range for blood tyrosine. Curation status: Incomplete ONSTR:ONSTR_6116517 Definition source: ONSTR curators Definition source: http://purl.bioontology.org/ontology/RCD/X74UV [RCDv3] blood specimen collecting Blood specimen collecting is collecting specimen from an organism where a portion of blood (venous, arterial or capillary) is collected from a human patient or study subject by making a small puncture (or incision) in patient's skin and blood vessel followed by collecting a portion of (leaked) blood in the protocol appropriate container. Curation status: Incomplete ONSTR:ONSTR_6126230 Definition source: ONSTR curators. percent daily energy intake from total protein intake percent daily energy from total protein percent energy from total protein Percent daily energy intake from total protein inatke is a percent daily energy intake datum providing the information about the quantity of energy derived from total amount of protein taken by a patient (enterally or parenterally) during the 24 hour time interval and that is expressed as a percentage of the total dietary energy intake. Curation status: Incomplete ONSTR:ONSTR_6127102 Definition source: ONSTR curators. urine chemical concentration measurement datum Urine chemical concentration measurement datum is a concentration measurement datum providing the information about the concentration of a observed chemical in the human urine specimen or processed urine specimen. Curation status: Incomplete ONSTR:ONSTR_6133111 Definition source: http://www.cdc.gov/growthcharts/who_charts.htm boys birth-to-24 months head circumference-for-age weight-for-length WHO growth chart Birth to 24 months: Boys, Head circumference-for-age and weight-for-length percentiles Boys birth-to-24 months head circumference-for-age weight-for-length WHO growth chart is a birth-to-24 months head circumference-for-age weight-for-length WHO growth chart that illustrates the distribution of head circumference measurements with respect to age, and weight (body mass) measurements with respect to body height (length) measurements in a population of healthy boys 0 to 24 months of age. Curation status: Incomplete ONSTR:ONSTR_6133211 Definition source: ONSTR curators. average daily dietary proline intake during observed time interval average daily dietary Pro intake daily Pro intake Average daily proline intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid proline contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_6156091 Definition source: ONSTR curators. newborn screening short-term follow-up protocol NBS STFU protocol NBS-STFU protocol STFU protocol Newborn screening short-term follow-up protocol is a newborn screening system protocol specifying all actions to be performed and agents involved in processes of short-term follow-up after the identifying a positive newborn screening result. Curation status: Incomplete. 31.0 ONSTR:ONSTR_6159839 Definition source: ONSTR curators. newborn dried blood spot screening finding Newborn dried blood spot screening finding is a newborn screening test finding that is an output of newborn dried blood spot screening test analysis and that is based on the newborn's body mass measured at birth, age of dried blood spot specimen collection (less than 31 days) and whole blood amino acid, carnitine and carnitine ester concentrations and conentrations' ratios (i.e. blood amino acid and acyl-carnitine profile respectively). Newborn dried blood spot screening finding provides the information about the potential presence (or absence) of an inheritable disease detectable through newborn dried blood spot screening. Curation status: Incomplete ONSTR:ONSTR_6176540 Definition source: ONSTR curators. average daily dietary asparagine intake during observed time interval average daily dietary Asn intake daily Asn intake Average daily asparagine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid asparagine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_6184665 Definition source: ONSTR curators. Definition source: http://purl.org/obo/owl/GO#GO_0048589 developmental head growth Developmental head growth is developmental growth such that the increase in size and mass of human head has the outcome of reaching adult head size and mass. Curation status: Incomplete ONSTR:ONSTR_6191227 Definition source: http://www.acmg.net genetic councelor role Genetic counselor role is a health care provider role that is realized in processes of providing information and supportive counseling to patients and families affected by or at risk for genetic conditions, identify genetic risks, investigating problems, interpreting and communicating information about genetic disorders, analyzing inheritance patterns and risks of recurrence and reviewing available options with patients and families. Curation status: Incomplete. ONSTR:ONSTR_6196515 Definition source: ONSTR curators percent upper tolerable manganese intake level datum Percent upper tolerable manganese intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of manganese consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for manganese. Curation status: Incomplete ONSTR:ONSTR_6203442 Definition source: ONSTR curators. age at initial newborn dried blood spot screening specimen collection measurement datum age at initial DBS collection Age at initial newborn dried blood spot screening specimen collection measurement datum is age at newborn screening measurement datum that is the result of measurement of time elapsed from birth of a neonate until the the instant of dried blood spot specimen collection during the initial newborn screening. Curation status: Incomplete ONSTR:ONSTR_6211529 Definition source: 2000 CDC Growth Charts for the United States: Methods and development, Vital and Health Statistics, Series 11, Number 246, Department of Health and Human Services, CDC National Center for Health Statistics, Hyattsville, MD, May 2002, pp 1 and 23-24. Definition source: http://www.cdc.gov/growthcharts/charts.htm To refer to the height quality of human body, in the case of neonates and infants word "length" is commonly used, while in children, adolescents and adults word "stature" has the same reference. In fact, all four language expressions "height", "body height", "length" and "stature" are commonly used in ambiguous manner to refer to both the quality of human body and to the measurement datum associated with that quality. This ambiguity is avoided in ONSTR. Weight-for-height percentile charts (also called weight-for-lenght percentile charts) are available for infants age 0-36 months and preschoolers age 2 to 5 years, but not for children and adolescents age 2 to 20 years, as in the case of weight-for-age and height-for-age charts. weight-for-height percentile chart weight-for-length chart weight-for-stature chart Weight-for-height percentile chart is a CDC individual growth chart consisting of smoothed percentile curves illustrating the distribution(s) of weight measurement data (body mass measurements) with respect to height measurement data (body height measurements) in a population of healthy children 0 to 36 months of age or 2 to 5 years of age. Curation status: Incomplete ONSTR:ONSTR_6225502 Definition source: ONSTR curators percent estimated average iron requirement datum Percent estimated average iron requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of iron consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for iron. Curation status: Incomplete ONSTR:ONSTR_6225611 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.356-361. low average daily dietary molybdenum intake low mean molybdenum intake low molybdenum intake Low average daily dietary molybdenum intake is an average daily dietary molybdenum intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary molybdenum for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6241199 Definition source: ONSTR curators. adequate nutrient intake for population age 9 years and older Adequate nutrient intake for population age 9 years and older is an adequate nutrient intake datum that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy population age 9 years and older. Curation status: Incomplete ONSTR:ONSTR_6254359 Definition source: ONSTR curators. average daily dietary valine intake during observed time interval average daily dietary Val intake daily Val intake mean valin intake Average daily valine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid valine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_6255242 Definition source: ONSTR curators. percent recommended dietary niacin allowance Percent recommended dietary niacin allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary niacin consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for niacin. Curation status: Incomplete ONSTR:ONSTR_6284135 Definition source: ONSTR curators percent estimated average amino-acid requirement datum Percent estimated average amino-acid requirement is a percent estimated average macronutrient requirement that provides the information about the quantity of specific amino-acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for the observed amino-acid. Curation status: Incomplete ONSTR:ONSTR_6288330 Definition source: http://www.cdc.gov/growthcharts/ weight-for-age percentile chart weight-for-age chart weight-for-age percentile chart weight-for-age percentiles Weight-for-age percentile chart is a CDC individual growth chart consisting of smoothed percentile curves illustrating the distribution(s) of weight measurement data (body mass measurements) with respect to age in a population of healthy children of specific age group (e.g. birth to 36 months of age). Curation status: Incomplete ONSTR:ONSTR_6325182 Definition source: ONSTR curators. average daily dietary aspartic acid intake per body mass during observed time interval Average aspartic acid intake per body mass during observed time interval is an average amino-acid intake per body mass during observed time interval information denoting the average quantity of aspartic acid contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_6330670 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.170-181. low average daily dietary vitamin A intake low mean vitamin A intake low vitamin A intake Low average daily dietary vitamin A intake is an average daily dietary vitamin A intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary vitamin A for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6345843 Definition source: ONSTR curators. upper tolerable nutrient intake level for population age 9 years and older Upper tolerable nutrient intake level for population age 9 years and older is an upper tolerable nutrient intake level for healthy population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of population 9 years or older. Curation status: Incomplete ONSTR:ONSTR_6356535 Definition source: ONSTR curators. blood octanoylcarnitine-to-acetylcarnitine concentration ratio datum Lab abbreviation: C8/C2 blood C8-to-C2 blood C8/C2 blood octanoylcarnitine-to-acetylcarnitine ratio Blood octanoylcarnitine-to-acetylcarnitine concentration ratio datum is a blood carnitine ester concentration ratio that provides the information about the ratio between octanoylcarnitine and acetylcarnitine quantities present in the whole blood, blood eluate or blood plasma specimen. Curation status: Incomplete ONSTR:ONSTR_6358913 Definition source: ONSTR curators. nutritional item intake record diet history record feeding record food intake record Nutritional item intake record is a document that is the output of nutritional item intake recording, and that contains the information about the types and quantites of food items, nutritional supplements, medical foods, food amino-acid excahnges patient has consumed in a time interval relevant for dietary analysis (last 24 hours, one, two or three days, seven days or thirty days). Nutritional item intake record also contains other patient related information such as patient's name, date of birth, body height and weight, prescribed and taken medications. Curation status: Incomplete ONSTR:ONSTR_6363940 Definition source: ONSTR curators. percent recommended dietary carotenoid allowance Percent recommended dietary carotenoid allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary carotenoid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for carotenoid. Curation status: Incomplete ONSTR:ONSTR_6378395 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 70-81. acceptable macronutrient distribution range for adult population Acceptable macronutrient distribution range for adult population is an acceptable macronutrient distribution range datum that is assumed to adequate for healthy adult population (older than 18 years of age). Curation status: Incomplete ONSTR:ONSTR_6379416 Definition source: ONSTR curators. average daily dietary linoleic acid intake per body mass during observed time interval average daily LA intake per body mass daily LA intake per body mass Average daily dietary linoleic acid intake per body mass during observed time interval is an average daily dietary fatty acid intake per body mass during observed time interval denoting the average quantity of dietary linoleic acid (LA) contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_6380837 Definition source: ONSTR curators percent upper tolerable tryptophan intake level datum Percent upper tolerable tryptophan intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid tryptophan consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for tryptophan. Curation status: Incomplete ONSTR:ONSTR_6398203 Definition source: ONSTR curators. blood combined isoleucine and leucine-to-phenylalanine concentration ratio XLeu-to-Phe XLeu/Phe blood XLeu-to-Phe ratio blood XLeu/Phe blood Xleu/Phe Blood combined isoleucine and leucine-to-phenylalanine concentration ratio is a blood amino-acid concentration ratio datum that provides the information about the how many times the concentration of leucine in the blood is greater than the that of phenylalanine. Curation status: Incomplete ONSTR:ONSTR_6402533 Definition source: ONSTR curators. recommended dietary allowance for female population age 70 years and older Recommended dietary allowance for female population age 70 years and older is a recommended dietary allowance for non-pregnant non-lactating female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy female population age 70 years and older. Curation status: Incomplete ONSTR:ONSTR_6403260 Definition source: ONSTR curators. blood fatty acid concentration therapeutic range datum Blood fatty acid concentration therapeutic range datum is a blood chemical concentration therapeutic range datum that provides the information about the set of values (limited by the minimal and maximal values) of blood concentration measurements of an observed fatty acid, such that the fatty acid concentration values falling within this range do not produce or produce minimal toxic effects to most of the members of the observed population. Curation status: Incomplete ONSTR:ONSTR_6405272 Definition source: ONSTR curators. height-for-age percentile derivation Height-for-age percentile derivation is developmental growth indicator derivation with the goal to determine (or give best possible approximation) height-for-age percentile for given child at the time of physical examination. In order to derive height-for-age percentile information about child's body height and age is first plotted with respect to the height and age scales of the age and sex appropriate height-for-age growth chart; position of the resulting point is then compared with respect to height-for-age percentile curves comprising height-for-age growth chart; height-for-age percentile is then determined (or maximally approximated) based on the closest percentile curve. Curation status: Incomplete ONSTR:ONSTR_6432856 Definition source: http://en.wikipedia.org/wiki/Neonatal_nursing Definition source: http://www.innerbody.com/careers-in-health-/nicu-nurcing-careers.html NICU nurse role is realized in processes of (roughly) Level II and level III of neonatal care. At level II NICU nurse provides intermediate or special care for premature ill newborns. At this level, infants may need special therapy provided by nursing staff, or may simply need more time before being discharged. At Level III, the Neonatal intensive care unit (NICU), treats newborns who cannot be treated in the other levels and are in need of high technology to survive, such as breathing and feeding tubes. Nurses comprise over 90 percent of the NICU staff. [Source: http://en.wikipedia.org/wiki/Neonatal_nursing ] NICU nurses along with physicians formulate nursing care plans and assess, plan, implement and evaluate the effectiveness of treatments in these plans. On a daily basis they administer medications, perform complex procedures, work with complicated technology, and consult with an interdisciplinary healthcare team to coordinate all aspects of a patient's care. [Source: http://www.innerbody.com/careers-in-health-/nicu-nurcing-careers.html] newborn intensive care unit nurse role NICU nurse role Newborn intensive care unit nurse role is a nurse role that is realized in the process of providing nursing care to newborn infants up to 28 days post birth who are diagnosed with prematurity, congenital defects, illness, delivery complications or other medical conditions. Curation status: Incomplete. ONSTR:ONSTR_6437538 Definition source: ONSTR curators. upper tolerable nutrient intake level for children population age 1-to-3 years Upper tolerable nutrient intake level for children population age 1-to-3 years is an upper tolerable nutrient intake level for children population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy children population 1 to 3 years of age. Curation status: Incomplete ONSTR:ONSTR_6449370 Definition source: ONSTR curators percent upper tolerable pantothenic acid intake level datum Percent upper tolerable pantothenic acid intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of pantothenic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for pantothenic acid. Curation status: Incomplete ONSTR:ONSTR_6457549 Definition source: ONSTR curators percent estimated average docosahexaenoic acid requirement datum Percent estimated average docosahexaenoic acid requirement is a percent estimated average fatty acid requirement that provides the information about the quantity of docosahexaenoic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for docosahexaenoic acid. Curation status: Incomplete ONSTR:ONSTR_6464019 Definition source: ONSTR curators. average daily dietary vitamin C intake during observed time interval mean vitamin C intake Average daily dietary vitamin C intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of vitamin C contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_6470593 Definition source: ONSTR curators. NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. negative newborn dried blood spot screening finding for infants with body mass at birth greater than 2500 grams Negative newborn dried blood spot screening finding for infants with body mass at birth greater than 2500 grams is a newborn dried blood spot screening finding for infants with body mass greater than 2500 grams that is based on whole blood amino acid and carnitine ester concentrations and concentration ratios that fall within the laboratory established normal range for a given blood chemical concentration or concentration ratio. Curation status: Incomplete ONSTR:ONSTR_6482088 Definition source: ONSTR curators. dried blood spot specimen creation measurement datum DBS collection date DBS date Dried blood spot specimen creation measurement datum is a specimen creation measurement datum that provides the information about the time the dried blood spot specimen have been created. Curation status: Incomplete ONSTR:ONSTR_6486199 Definition source: ONSTR curators food item measurement unit Food item measurement unit is a derived unit that is measure of the quantity of food items or medical food. Curation status: Incomplete ONSTR:ONSTR_6487114 Definition source: ONSTR curators. blood plasma tyrosine concentration measurement datum plasma Tyr plasma Tyr level plasma Tyr status plasma tyrosine concentration plasma tyrosine measurement plasma tyrosine status Blood plasma tyrosine concentration measurement datum is a blood plasma amino acid concentration measurement datum that provides the information about the quantity of amino acid alanine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_6495598 Definition source: ONSTR curators percent upper tolerable arsenic intake level datum Percent upper tolerable arsenic intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of arsenic consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for arsenic. Curation status: Incomplete ONSTR:ONSTR_6500060 Definition source: ONSTR curators. adequate nutrient intake male population age 14-to-18 years Adequate nutrient intake for male population age 14-to-18 years is an adequate nutrient intake for male population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy male population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_6501512 Definition source: ONSTR curators percent adequate vitamin C intake datum Percent adequate vitamin C intake is a percent adequate vitamin intake that provides the information about the quantity of vitamin C consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for vitamin C. Curation status: Incomplete ONSTR:ONSTR_6507737 Definition source: ONSTR curators. estimated average nutrient requirement for female population age 19-to-30 years Estimated average nutrient requirement for female population age 19-to-30 years is an estimated average nutrient requirement for non-pregnant non-lactating female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of female population of 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_6514703 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. low average daily dietary valine intake low mean valine intake low valine intake Low average daily dietary valine intake is an average daily dietary valine intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary valine for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_6516375 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 girls birth-to-36-months weight-for-age percentile chart Weight-for-age percentiles: Girls, birth to 36 months girls weight-for-age birth to 36 months percentile chart Girls birth-to-36-months weight-for-age percentile chart is a birth-to-36-months weight-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of weight measurement data (body mass measurements) with respect to age in a population of healthy girls 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_6550722 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. normal average daily dietary threonine intake normal mean threonine intake normal threonine intake Normal average daily dietary threonine intake is an average daily dietary histidine intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary threonine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6562510 Definition source: ONSTR curators. Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Head_Circumference head circumference Head circumference is human body quality that inheres in human head by virtue of the perimeter of the head at its widest point. Curation status: Incomplete ONSTR:ONSTR_6564852 Definition source: ONSTR curators percent adequate magnesium intake datum Percent adequate magnesium intake is a percent adequate dietary mineral intake that provides the information about the quantity magnesium consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for magnesium. Curation status: Incomplete ONSTR:ONSTR_6583789 Definition source: ONSTR curators. estimated average nutrient requirement for male population age 9-to-13 years Estimated average nutrient requirement for male population age 9-to-13 years is an estimated average nutrient requirement for male population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of male population age 9 to 13 years of age. Curation status: Incomplete ONSTR:ONSTR_6598460 Definition source: ONSTR curators. recommending disease specific confirmatory test Recommending disease specific confirmatory test is a health care process that realizes the newborn screening nurse or newborn screening coordinator role and that consists of providing the primary care physician with the information about which tests (assays) needed to be done in order to confirm the presence or absence of a particular inherited metabolic disease that the patient has a positive newborn dried blood spot screen result. Curation status: Incomplete ONSTR:ONSTR_6614057 Definition source: ONSTR curators. blood specimen creation objective Blood specimen creation objective is specimen creation objective to obtain a blood specimen (a portion of venous, arterial of capillary blood) from a human patient to use it as an input for further investigation. Curation status: Incomplete ONSTR:ONSTR_6631562 Definition source: http://en.wikipedia.org/wiki/Audiology audiologist role Audiologist role is a physician role that is realized by a human trained in medicine specializing in audiology and during processes of identifying, diagnosing, treating and monitoring of the auditory and vestibular system portion of the ear. Curation status: Incomplete. ONSTR:ONSTR_6635527 Definition source: ONSTR curators. dietary reference intake percentage %DRI Dietary reference intake percentage is a percent unit (dimensionless unit) which denotes the quantity of a dietary nutrient that may be (or has been) consumed by a human as a percentage of the dietary reference intake for that specific nutrient. Curation status: Incomplete ONSTR:ONSTR_6640610 Definition source: ONSTR curators. food item datum Food item datum is a nutritional item datum that provides the information about the kinds, quantities and nutrient content of food items prescribed to or consumed by a human patient. Curation status: Incomplete ONSTR:ONSTR_6645105 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp.234-243. high average daily dietary vitamin E intake high mean vitamin E intake high vitamin E intake High average daily dietary vitamin E intake is an average daily dietary vitamin E intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary vitamin E for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6649635 Definition source: ONSTR curators. average daily dietary amino-acid intake during observed time interval Average daily dietary amino-acid intake over observed time interval datum is an average daily dietary micronutrient intake during observed time interval denoting the average quantity of a given amino-acid or two amino-acids combined contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_6661323 Definition source: ONSTR curators percent adequate cholesterol intake datum Percent adequate cholesterol intake is a percent adequate macronutrient intake that provides the information about the quantity of specific dietary cholesterol consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for cholesterol. Curation status: Incomplete ONSTR:ONSTR_6675375 Definition source: ONSTR curators. adequate nutrient intake for lactating female population age 14-to-18 years Adequate nutrient intake for lactating female population age 14-to-18 years is an adequate nutrient intake for lactating population that that denotes the average daily intake of a nutrient based on the observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy lactating female population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_6680350 Definition source: http://en.wikipedia.org/wiki/Human_gastrointestinal_tract Definition source: http://purl.bioontology.org/ontology/MSH/D004750 Enteral administration (and similarly, parenteral administration) is, by implication, applicable only to the organisms that anatomically have the alimentary canal (and/or some form of gastrointestinal tract). enteral administration enteral route enteral route of administration Enteral administration is an administering substance in vivo where material entity (e.g.nutritional item or medication) is introduced into the organism's alimentary canal (oral cavity or gastrointestinal (GI) tract). Curation status: Incomplete ONSTR:ONSTR_6691783 Definition source: ONSTR curators. adequate nutrient intake male population Adequate nutrient intake for male population is an adequate nutrient intake for population age 9 years and older that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy male population age 9 years and older. Curation status: Incomplete ONSTR:ONSTR_6702385 Definition source: ONSTR curators. adequate nutrient intake for pregnant female population age 31-to-50 years Adequate nutrient intake for pregnant female population age 31-to-50 years is an adequate nutrient intake for pregnant female population that denotes the average daily intake of a nutrient based on the observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy pregnant female population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_6706610 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 328-339. normal average daily dietary magnesium intake normal magnesium intake normal mean magnesium intake Normal average daily dietary magnesium intake is an average daily dietary magnesium intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary magnesium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6728067 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp. 386-396. normal average daily dietary chloride intake normal chloride intake normal mean chloride intake Normal average daily dietary chloride intake is an average daily dietary chloride intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary chloride for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6732721 Definition source: ONSTR curators. metabolic dietitian role Metabolic dietitian role is a dietitian role that is realized in processes of nutrition care specifically related to treatment and management of patients with inherited or congenital metabolic diseases. Curation status: Incomplete. ONSTR:ONSTR_6734136 Definition source: http://en.wikipedia.org/wiki/Geneticist geneticist role Geneticist role is a health care provider role that is realized by a human professionally trained in biology or medicine specializing in genetics, and during processes of research in the field of heredity and genetic variation, evaluation, diagnosing and management of patients with inherited condition or congenital malformations, genetic risk calculation, mutation analysis, referral of patients to other specialists. Curation status: Incomplete. ONSTR:ONSTR_6745429 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.386-396. high average daily dietary sodium intake high mean natrium intake high mean sodium intake high natrium intake high sodium intake High average daily dietary sodium intake is an average daily dietary sodium intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary sodium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6757046 This class belongs to ChEBI domain and will be replaced by the ChEBI class at a later date. 4-alphahydroxy-dihydrobiopterin 4alpha-carbinolamin pterin-4alpha-carbinolamine Curation status: Incomplete ONSTR:ONSTR_6769309 Definition source: ONSTR curators. blood chemical concentration measurement datum Blood chemical concentration measurement datum is a concentration measurement datum providing the information about the concentration of a observed chemical in the human blood specimen or processed blood specimen (blood plasma, serum or dried blood spot eluate). Curation status: Incomplete 7.0 12.0 58.0 7.0 93.0 1.0 4.0 37.0 14.0 19.0 9.0 14.0 27.0 14.0 19.0 19.0 24.0 4.0 9.0 9.0 14.0 28.0 31.0 35.0 15.0 ONSTR:ONSTR_6785015 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. high average daily dietary valine intake per body mass High average daily dietary valine per body mass is an average daily valine intake per body mass during observed that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary valine patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6828601 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 286-295. normal average daily dietary calcium intake normal calcium intake normal mean calcium intake Normal average daily dietary calcium intake is an average daily dietary calcium intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary calcium for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6830160 Definition source: ONSTR curators. average daily dietary thiamine intake during observed time interval average daily dietary vitamin B1 intake during observed time interval daily dietary thiamine intake daily dietary vitamin B1 intake daily vitamin B1 intake mean thiamine intake Average daily dietary thiamine intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of thiamine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete 10.0 15.0 360.0 900.0 ONSTR:ONSTR_6832076 Definition source: ONSTR curators. mild PKU hyperphenylalaninemia finding Mild PKU hyperphenylalaninemia finding is a PKU hyperphenylalaninemia finding based on the value of blood phenylalanine concentration measurement datum or plasma phenylalanine concentration measurement datum falling within the range of 360 - 900 μmol/L (or 10 - 15 mg/dL). Curation status: Incomplete ONSTR:ONSTR_6842282 Definition source: ONSTR curators percent adequate vitamin B6 intake datum Percent adequate vitamin B6 intake is a percent adequate vitamin intake that provides the information about the quantity of vitamin B6 consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for vitamin B6. Curation status: Incomplete ONSTR:ONSTR_6854872 Definition source: ONSTR curators percent upper tolerable dietary mineral intake level datum Percent upper tolerable dietary mineral intake level is a percent upper tolerable micronutrient intake level that provides the information about the quantity of specific dietary mineral consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed dietary mineral. Curation status: Incomplete ONSTR:ONSTR_6863786 Definition source: ONSTR curators. percent recommended dietary nickel allowance Percent recommended dietary nickel allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary nickel consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for nickel. Curation status: Incomplete ONSTR:ONSTR_6867187 Definition source: ONSTR curators. nutrient intake analysis diet intake analysis dietary analysis nutritional analysis Nutrient intake analysis is a data transformation performed by nutrient analyzer software where the data transformation inputs are the type and quantity of food items been consumed and outputs of the analysis are the quantity and the energy value of nutrients contained in the food item(s) been analyzed. Curation status: Incomplete ONSTR:ONSTR_6876575 Definition source: ONSTR curators. percent recommended dietary magnesium allowance Percent recommended dietary magnesium allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary magnesium consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for magnesium. Curation status: Incomplete ONSTR:ONSTR_6883808 Definition source: ONSTR curators percent adequate alanine intake datum Percent adequate alanine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid alanine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for alanine. Curation status: Incomplete ONSTR:ONSTR_6893976 Definition source: ONSTR curators volume per unit time Volume per unit time is a nutrient intake per unit time that is a measure of the number volume units of a particular nutrient taken by a human in time interval denoted by a time unit. Curation status: Incomplete ONSTR:ONSTR_6897756 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.244-253. normal average daily dietary folacin intake normal folacin intake normal folate intake normal folic acid intake normal mean folate intake Normal average daily dietary folacin intake is an average daily dietary folacin intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary folacin (folate) for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete 7.0 12.0 43.0 7.0 88.0 1.0 4.0 28.0 14.0 19.0 9.0 14.0 21.0 14.0 19.0 19.0 19.0 4.0 9.0 9.0 14.0 22.0 25.0 30.0 15.0 ONSTR:ONSTR_6917181 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] high average daily dietary isoleucine intake per body mass High average daily dietary isoleucine per body mass is an average daily isoleucine intake per body mass during observed that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary isoleucine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_6924943 Definition source: ONSTR curators. recommended dietary allowance for female population age 31-to-50 years recommended dietary allowance for lactating female population age 31-to-50 years Recommended dietary allowance for female population age 31-to-50 years is a recommended dietary allowance for non-pregnant non-lactating female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy female population 31 to 50 years of age. Recommended dietary allowance for lactating female population age 31-to-50 years is a recommended dietary allowance for lactating female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of lactating healthy female population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_6949605 Definition source: ONSTR curators. blood methionine-to-phenylalanine concentration ratio Met-to-Phe Met/Phe blood Met-to-Phe ratio blood Met/Phe Blood methionine-to-phenylalanine concentration ratio is a blood amino-acid concentration ratio datum that provides the information about the how many times the concentration of methionine in the blood is greater than that of phenylalanine. Curation status: Incomplete ONSTR:ONSTR_6955767 Definition source: ONSTR curators. percent recommended dietary tryptophan allowance Percent recommended dietary tryptophan allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary tryptophan consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid tryptophan. Curation status: Incomplete ONSTR:ONSTR_6972256 "food item name" does not denote a class of any given food item, but refers to a particular of that class. For instance food item name "apple pie" would not denote the class of entities that by their properties can be named as "apple pie". What it would refer to is a particular of the "apple pie", that is "an apple pie that John ate yesterday after noon at his beach house in Virginia Beach VA". Definition source: ONSTR curators. food item name Food item name is a nutritional item name referring to the instance of a specific food item. Curation status: Incomplete ONSTR:ONSTR_6981186 Definition source: ONSTR curators. dietary supplement quantity datum Dietary supplement quantity datum is a nutritional item quantity datum that provides the information about the quantity of dietary supplement (consumed or prescribed). Curation status: Incomplete ONSTR:ONSTR_6981713 Definition source: ONSTR curators percent estimated average protein requirement datum Percent estimated average protein requirement is a percent estimated average macronutrient requirement that provides the information about the total quantity of proteins consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for (total) protein intake. Curation status: Incomplete ONSTR:ONSTR_6991523 Definition source: ONSTR curators. estimated average nutrient requirement for population age 9 years and older Estimated average nutrient requirement for population age 9 years and older is an estimated average nutrient requirement datum that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of human population of 9 years of age and older. Curation status: Incomplete ONSTR:ONSTR_7003914 Definition source: http://purl.org/obo/owl/GO#GO_0016491 oxidoreductase complex A protein complex that functions as a catalyst of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Curation status: Incomplete ONSTR:ONSTR_7014928 Definition source: ONSTR curators. average daily dietary cysteine intake per body mass during observed time interval Average daily cysteine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid cysteine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7023842 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.262-269. high average daily dietary pantothenic acid intake high mean pantothenic acid intake high pantothenic acid intake High average daily dietary pantothenic acid intake is an average daily dietary pantothenic acid intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary pantothenic acid for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7033250 Definition source: ONSTR curators percent upper tolerable arachidonic acid intake level datum Percent upper tolerable arachidonic acid intake level is a percent upper tolerable fatty acid intake level that provides the information about the quantity of arachidonic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for arachidonic acid. Curation status: Incomplete ONSTR:ONSTR_7059751 Definition source: ONSTR curators percent adequate vitamin B12 intake datum Percent adequate vitamin B12 intake is a percent adequate vitamin intake that provides the information about the quantity of vitamin B12 consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for vitamin B12. Curation status: Incomplete ONSTR:ONSTR_7063454 Definition source: ONSTR curators. blood plasma carnitine ester concentration measurement datum blood plasma acyl-carnitine concentration plasma acyl-carnitine plasma acyl-carnitine concentration Blood plasma carnitine ester concentration measurement datum is a blood carnitine ester concentration measurement datum that provides the information about the quantity of a given carnitine ester in the human blood plasma specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_7087991 Definition source: ONSTR curators. average daily dietary nickel intake during observed time interval average dietary Ni intake daily dietary nickel intake daily nickel intake Average daily dietary nickel intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary nickel contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_7112104 Definition source: ONSTR curators. Definition source: Scheuermann, R.H., Ceusters, W., Smith, B. (2009) Toward an Ontological Treatment of Disease and Diagnosis. Proceedings of the 2009 AMIA Summit on Translational Bioinformatics, San Francisco, CA, p.116-120. disordered kidney epithelial cell Disordered kidney epithelial cell is a kidney epithelial cell that is physically abnormal and whose abnormality may contribute to the emergence of a disease. Curation status: Incomplete ONSTR:ONSTR_7112823 Definition source: http://en.wikipedia.org/wiki/Inborn_error_of_metabolism Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Inborn_Errors_of_Metabolism congenital metabolic disease inborn errors of metabolism inherited metabolic disease A large class of constitutional genetic diseases, involving the disorders of metabolism that result from inborn genetic mutations of single genes (inherited or acquired in utero) that code for enzymes that facilitate conversion of various substances (substrates) into others (products) and which may be present at birth and lead to disturbances in carbohydrate, lipid, lysosomal storage or amino acid metabolism. These diseases are usually characterized of accumulation of substances which are toxic or interfere with normal function, or the reduced ability to synthesize essential compounds. Curation status: Incomplete ONSTR:ONSTR_7113951 Definition source: ONSTR curators. average daily dietary vitamin D intake during observed time interval average dietary vitamin D intake daily dietary vitamin D intake daily vitamin D intake mean vitamin D intake Average daily dietary vitamin D intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of vitamin D contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days) Curation status: Incomplete ONSTR:ONSTR_7136938 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. high average daily dietary histidine intake high histidine intake high mean histidine intake High average daily dietary histidine intake is an average daily dietary histidine intake during observed time interval that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary histidine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete 2500.0 ONSTR:ONSTR_7139931 Definition source: ONSTR curators. newborn dried blood spot screening finding for infants with body mass greater than 2500 grams Newborn dried blood spot screening finding for infants with body mass at birth greater than 2500 grams is a newborn dried blood spot screening finding based on newborn's body mass (weight) measured at birth was greater than 2500 grams, age of dried blood spot specimen collection and whole blood amino acid and carnitine ester concentrations and conentrations' ratios (i.e. blood amino acid and acyl-carnitine profile respectively). Curation status: Incomplete ONSTR:ONSTR_7140514 Definition source: ONSTR curators. average daily dietary isoleucine intake per body mass during observed time interval Average daily isoleucine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid isoleucine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7148009 Blood 1,25(OH)2D level is generally not considered to be a good indicator of vitamin D status. It has relatively short half-life of 15 hours and its blood concentrations as closely regulated by parathyroid hormone, calcium and phosphate. Levels of 1,25(OH)2D do not typically decrease until the vitamin D deficiency is severe. [Source: http://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ ] Definition source: http://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ Many lab websites have the information that the 25-hydroxy vitamin D test provides the information about the about the sum of quantity of 25-hydroxy vitamin D3 and 25-hydroxy vitamin D2. Formula 25(OH)D, however, generally refers to 25-hydroxycholecalciferol which is 25-hydroxy form of vitamin D3 (cholecalciferol) but not 25-hydroxy form of vitamin D2 (ergocalciferol). Vitamin D3 is a seco-steroid while vitamin D2 is a seco-ergostan (according to ChEBI), two structurally different chemical entities. blood serum 1,25-dihydroxyvitamin D concentration measurement datum blood 1,25(OH)2D level blood 1,25-dihydroxyvitamin D level blood calcitriol level circulating 1,25(OH)2D circulating 1,25-OH vitamin D serum 1,25(OH)2D level Blood serum 1,25-dihydroxyvitamin D concentration measurement datum is a blood vitamin D concentration measurement datum that provides the information about the sum quantity of 1,25-dihydroxycholecalciferol (also known as calcitriol or 1,25-hydroxyvitamin D or 1,25(OH)2D, the physiologically active form of vitamin D) and 1,25-dihydroxyergocalciferol (also known as 1,25-dihydroxy vitamin D2) in the blood serum specimen. Curation status: Incomplete Need to doublec heck vitamin D2 forms. ONSTR:ONSTR_7149155 Definition source: ONSTR curators. estimated average nutrient requirement for pregnant female population age 19-to-30 years Estimated average nutrient requirement for pregnant female population age 19-to-30 years is an estimated average nutrient requirement for pregnant female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of population of pregnant females 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_7156237 Definition source: ONSTR curators. Definition source: http://purl.obolibrary.org/obo/VT_0005311 blood plasma amino acid concentration measurement datum circulating amino acid level pglasma amino acid concentration plasma amino acid content plasma amino acid level plasma amino acid measurement Blood plasma amino acid concentration measurement datum is a blood amino acid concentration measurement datum that is the output of various measurement assays (electrophoresis, gas chromatography, liquid chromatography, liquid chromatography-mass spectrometry, liquid chromatography-tandem mass spectrometry, ion exchange chromatography) measuring the concentration of an observed amino acid in human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_7166816 Definition source: ONSTR curators percent estimated average chloride requirement datum Percent estimated average chloride requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of chloride consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for chloride. Curation status: Incomplete ONSTR:ONSTR_7188815 Definition source: ONSTR curators. long-term follow-up patient data record Long-term follow-up patient data record is a data collection consisting of all data items pertaining to one particular patient and that is collected for purposes of providing health care to the patient. Curation status: Incomplete ONSTR:ONSTR_7192524 Definition source: ONSTR curators. average daily dietary linoleic acid intake during observed time interval average daily LA intake daily LA intake mean linoleic acid intake Average daily dietary linoleic acid intake over observed time interval datum is an average daily dietary fatty acid intake during observed time interval denoting the average quantity of linoleic acid contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_7201608 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. normal average daily dietary lysine intake normal lysine intake normal mean lysine intake Normal average daily dietary lysine intake is an average daily dietary histidine intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary lysine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7216679 Definition source: Rodwell W., S. (1989) Nutrition and diet therapy. 6th Ed. Times Mirror/Mosby College Publishing. St. Luis, MO, pp.5. micronutrient Dietary micronutrient is a dietary nutrient that is introduced into human body in small amounts and serves to regulate and control bodily processes. Curation status: Incomplete ONSTR:ONSTR_7226853 Definition source: ONSTR curators percent upper tolerable nickel intake level datum Percent upper tolerable nickel intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of nickel consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for nickel. Curation status: Incomplete ONSTR:ONSTR_7239630 Definition source: ONSTR curators. newborn screening system protocol Newborn screening system protocol is a protocol which specifies all actions to be performed and agents involved in all processes of newborn screening proper, short-term follow-up and lomg-term follow-up. Curation status: Incomplete. ONSTR:ONSTR_7240990 Definition source: ONSTR curators. food item-amino-acid exchange datum Food item-amino-acid exchange datum is a scalar measurement datum providing the information about the number of amino-acid exchange units corresponding to each listed food item consumed by a patient during the time interval relevant for the dietary analysis. Curation status: Incomplete ONSTR:ONSTR_7241977 Definition source: ONSTR curators. blood carnitine ester concentration ratio datum blood acyl-carnitine ratio Blood carnitine ester concentration measurement ratio is a blood chemical concentration ratio datum that provides the information about the ratio between the quantities of clinically relevant carnitine esters present in the whole blood, blood eluate or blood plasma. Curation status: Incomplete ONSTR:ONSTR_7243860 Definition source: ONSTR curators. average daily dietary copper intake per body mass during observed time interval Average daily dietary copper intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary copper contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7256013 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp. 386-396. low average daily dietary chloride intake low chloride intake low mean chloride intake Low average daily dietary chloride intake is an average daily dietary chloride intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary chloride for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7267693 Definition source: ONSTR curators Definition source: http://purl.bioontology.org/ontology/RCD/X74UW [RCDv3] venous blood specimen collecting venous blood sampling Venous blood specimen collecting is blood specimen collecting by which a portion of venous blood is collected from a human patient or study subject by making a small puncture in a vein followed by collecting a portion of (leaked) venous blood in a protocol appropriate container. Curation status: Incomplete ONSTR:ONSTR_7271477 Almost all states in the U.S. use second-tire screening for congenital hypothyroidism (CH) and test for thyroxine (T4) or thyroid stimulating hormone (TSH). [Source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf ] Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf Second- and third-tier tests are commonly done on the original dried blood spot specimen (collected during the initial newborn screening) and are to be distinguished from the repeated newborn screening testing that involves retesting on the original specimen performed by the screening laboratory, or second screening tests that require a fresh specimen (obtained during the repeated newborn screening). [Source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf ] Some newborn screening programs use a second-tier fluorometric test following an initial bacterial inhibition assay for phenylketonuria (PKU). [Source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf ] second-tier newborn dried blood spot screening process second-tier DBS screening Second-tier newborn dried blood spot screening process is a dried blood spot newborn screening proper system process commonly performed on the dried blood spot specimen collected during the initial newborn screening for the purposes of performing of additional test or tests following the previously positive initial screening result. Curation status: Incomplete 7.0 12.0 9.0 13.0 7.0 17.0 28.0 1.0 4.0 6.0 8.0 14.0 19.0 4.0 14.0 5.0 6.0 14.0 19.0 19.0 4.0 5.0 5.0 7.0 7.0 9.0 15.0 ONSTR:ONSTR_7272062 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] normal average daily dietary tryptophan intake per body mass Normal average daily dietary tryptophan per body mass is an average daily tryptophan intake per body mass during observed that has the value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) for dietary tryptophan per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7276057 Definition source: ONSTR curators. Peeled, cut and washed fruits and vegetables are not assumed as processed food items, as removing the crust from the fruit is a kind of mechanical processing which does not alter the chemical content of given fruit or vegitable. Fruits and vegetables eaten fresh, not cooked; uncooked meet and eggs. raw food item raw food Raw food item is a food item that is ingested by a human in it's natural form without prior thermal and/or chemical processing (cooking, steaming, backing, pasteurizing, pickling, brining etc.) by which the content and/or quantity of chemicals contained in a given food item is been altered. Curation status: Incomplete ONSTR:ONSTR_7289743 Definition source: ONSTR curators. average daily dietary riboflavin intake per body mass during observed time interval Average daily dietary riboflavin intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of riboflavin contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7294200 Definition source: http://purl.bioontology.org/ontology/MSH/D015992 body mass index calculation Body mass index calculation is data transformation with the goal to calculate body mass index by dividing given body mass (weight) by squared body height (BMI=weight/height^2). Curation status: Incomplete ONSTR:ONSTR_7308488 Definition source: ONSTR curators. Need better NL def. newborn screening system process NBS follow-up NBS follow-up system newborn screening system process Newborn screening system process is a planned process that is a collection of more or less time ordered health care processes involving multiple kinds of professionals and institutions with a general goal of identifying newborns with heritable and congenital disorders and providing them the best possible (often life long) medical care. Curation status: Incomplete ONSTR:ONSTR_7308738 Definition source: ONSTR curators percent estimated average tyrosine requirement datum Percent estimated average tyrosine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid tyrosine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for tyrosine. Curation status: Incomplete ONSTR:ONSTR_7313354 Definition source: ONSTR curators percent adequate riboflavin intake datum Percent adequate riboflavin intake is a percent adequate vitamin intake that provides the information about the quantity of riboflavin consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for riboflavin. Curation status: Incomplete ONSTR:ONSTR_7315205 Definition source: ONSTR curators. head circumference-for-age percentile Child head circumference centile HC-for-age percentile Head Occipital-frontal circumference Percentile Head circumference-for-age percentile is a developmental growth indicator showing the percentage of children (in a reference population distribution) that are of the same age as the assessed child, and whose head circumference measurement datum has equal or smaller value than that of the child being assessed at the time of given physical examination. Curation status: Incomplete 210.0 ONSTR:ONSTR_7317225 Definition source: ONSTR curators. NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. critical positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency for infants with body mass at birth greater than 2500 grams critical NDBS screen for PAH deficiency critical PAH deficiency screen critical PKU screen critical newborn screen for PAH deficiency critical newborn screen for PKU critical newborn screen for phenylketonuria Critical positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency for infants with body mass at birth greater than 2500 grams is a positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency for infants with body mass at birth greater than 2500 grams that is based on and abnormally high ratio between phenylalanine and tyrosine concentration (greater than 1.4) and abnormally high whole blood phenylalanine concentration (greater than 210 μM). This type of positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency requires immediate medical attention and/or intervention and treatment initiation. Curation status: Incomplete ONSTR:ONSTR_7321172 Definition source: ONSTR curators. estimated average nutrient requirement for male population age 14-to-18 years Estimated average nutrient requirement for male population age 14-to-18 years is an estimated average nutrient requirement for male population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of male population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_7333071 Definition source: ONSTR curators percent upper tolerable copper intake level datum Percent upper tolerable copper intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of copper consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for copper. Curation status: Incomplete ONSTR:ONSTR_7342395 Definition source: ONSTR curators percent upper tolerable potassium intake level datum Percent upper tolerable potassium intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of potassium consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for potassium. Curation status: Incomplete ONSTR:ONSTR_7346762 Definition source: ONSTR curators. estimated average nutrient requirement for lactating female population Estimated average nutrient requirement for lactating female is an estimated average nutrient requirement for female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of population of lactating females. Curation status: Incomplete ONSTR:ONSTR_7348043 Definition source: ONSTR curators prescribed dietary supplement datum Prescribed dietary supplement datum is a dietary supplement datum that provides the information about the kinds and quantities of dietary supplements prescribed by a dietitian (or physician) to be consumed by a human patient. Curation status: Incomplete ONSTR:ONSTR_7354824 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 6-12. low average daily total dietary carbohydrate intake low carbohydrate intake low daily carbohydrate intake low mean carbohydrate intake Low average daily total dietary carbohydrate intake is an average daily total dietary carbohydrate intake during observed time that has value less than that of the recommended dietary allowance (DRI-RDA) or the adequate intake (DRI-AI) for total dietary carbohydrates for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7355842 Definition source: ONSTR curators. upper tolerable nutrient intake level for pregnant female population Upper tolerable nutrient intake level for pregnant female population is an upper tolerable nutrient intake level for female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy pregnant female population. Curation status: Incomplete 7.0 12.0 13.0 7.0 28.0 1.0 4.0 8.0 14.0 19.0 4.0 14.0 6.0 14.0 19.0 19.0 5.0 7.0 9.0 15.0 ONSTR:ONSTR_7356771 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] high average daily dietary tryptophan intake per body mass High average daily dietary tryptophan per body mass is an average daily tryptophan intake per body mass during observed that has value that is greater than to that of the recommended dietary allowance (DRI-RDA) for dietary tryptophan per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7375219 Definition source: ONSTR curators. developmental growth indicator derivation Developmental growth indicator derivation is data transformation where the aim is to determine (or give best possible approximation of) human developmental growth indicator. Curation status: Incomplete ONSTR:ONSTR_7392505 Definition source: ONSTR curators. estimated average nutrient requirement for male population age 51-to-70 years Estimated average nutrient requirement for male population age 51-to-70 years is an estimated average nutrient requirement for male population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of male population 51 to 70 years of age. Curation status: Incomplete ONSTR:ONSTR_7411198 Definition source: ONSTR curators percent estimated average proline requirement datum Percent estimated average proline requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid proline consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for proline. Curation status: Incomplete ONSTR:ONSTR_7411819 Definition source: ONSTR curators. blood organic acid concentration ratio datum Blood fatty acid concentration ratio datum is a blood chemical concentration ratio datum that provides the information about the ratio of concentrations of clinically relevant fatty acids in the blood. Curation status: Incomplete ONSTR:ONSTR_7446995 Definition source: ONSTR curators. average daily dietary zinc intake during observed time interval average Zn intake daily zinc intake mean zinc intake Average daily dietary zinc intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary zinc contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_7448771 Definition source: ONSTR curators percent upper tolerable sulfate intake level datum Percent upper tolerable sulfate intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of sulfate consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for sulfate. Curation status: Incomplete ONSTR:ONSTR_7469225 Definition source: ONSTR curators. body mass at long-term follow-up visit measurement datum Body mass at long-term follow-up visit measurement datum is body mass measurement datum that is the result of mass measurement assay of human body height performed during physical examination at each scheduled patient long-term follow-up visit (interval visit). Curation status: Incomplete ONSTR:ONSTR_7469847 Definition source: ONSTR curators. percent recommended dietary vanadium allowance Percent recommended dietary vanadium allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary vanadium consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for vanadium. Curation status: Incomplete ONSTR:ONSTR_7489098 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.262-269. high average daily dietary niacin intake high mean niacin intake high niacin intake High average daily dietary niacin intake is an average daily dietary niacin intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary niacin for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7491011 Definition source: ONSTR curators percent estimated average fatty acid requirement datum Percent estimated average fatty acid requirement is a percent estimated average macronutrient requirement that provides the information about the quantity of specific fatty acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for the observed fatty acid. Curation status: Incomplete ONSTR:ONSTR_7505301 Definition source: ONSTR curators percent estimated average nickel requirement datum Percent estimated average nickel requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of nickel consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for nickel. Curation status: Incomplete ONSTR:ONSTR_7523695 Definition source: ONSTR curators. upper tolerable nutrient intake level for infant population age 7-to-12 months Upper tolerable nutrient intake level for infant population age 7-to-12 months is an upper tolerable nutrient intake level for infant population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy infant population 7 to 12 months of age. Curation status: Incomplete ONSTR:ONSTR_7534799 Definition source: http://medical-dictionary.thefreedictionary.com/parenteral+nutrition The nutrient contents in the solution may be customised to the individual patient needs and tolerance of the patient, or standardized solutions mat be used. Inndividual nutrient components may, if possible, be infused individually, or they may be injected into a bag of nutrient solution or intravenous fluids that is given to the patient. [Source: http://en.wikipedia.org/wiki/Parenteral_nutrition ] parenteral nutrition solution hyperalimentation formula hyperalimentation preparation hyperalimentation solution intravenous feeding solution parenteral fluid parenteral nutrition fluid parenteral nutrition formula Parenteral nutrition solution is a nutritional item in the form of a liquid that is introduced into human body intravenously or subcutaneously. The parenteral nutrition solution usually consists of physiologic saline with glucose, amino-acids, electrolytes, vitamins, (and may contain medications), which are not nutritionally complete but maintain fluid and electrolyte balance. Curation status: Incomplete ONSTR:ONSTR_7546388 Definition source: HP:0004923 Definition source: Physician's guide to the laboratory diagnosis of metabolic diseases. (2004) N. Blau, Duran, M. Blaskovics, M.E., Gibson, K.M. Eds. Springer Verlag, pp. 89. hyperphenylalaninemia HPA Hyperphenylalaninaemias Hyperphenylalaninemia (disease) congenital HPA A congenital metabolic disease of L-phenylalanine catabolism, characterized by the concentrations of amino acid L-phenylalanine in the blood that are considered by medical experts as clinically abnormal, and that is caused primarily by a deficiency of hepatic apoenzyme phenylalanine-4-hydrolase (PAH) or by the deficiency of one of the enzymes involved in PAH cofactor(i.e. tetrahydrobiopterin (BH4)) biosythesis (GTP cyclohydrolase 1 (GTPCH) and 6-pyruvol-tetrahydrobiopterin-syntase (PTPS)), or BH4 regeneration (dihydropteridine reductase (DHPR) and pterin carbinolamine-4alpha-dehydratase (PCD)). Curation status: Incomplete ONSTR:ONSTR_7549502 Definition source: ONSTR curators. dried blood spot specimen DBS dried blood spot Dried blood spot specimen is a processed specimen that is specified output of neonatal-heel prick blood specimen collecting or finger-prick capillary blood specimen collecting. Curation status: Incomplete ONSTR:ONSTR_7550260 Definition source: ONSTR curators. developmental growth indicator derivation objective Developmental growth indicator derivation objective is data transformation objective where the goal of data transformation is to determine (or approximate) the developmental growth indicator from the appropriate input information. Curation status: Incomplete ONSTR:ONSTR_7555475 Definition source: http://asha.org./public/hearing/Hearing-Screening-and-Hearing-Evaluation/ In the United States hearing screening is often referred as Early Hearing Detection and Intervention (EHDI) practice of screening every newborn for hearing loss prior to hospital discharge. All states and the District of Columbia have Early Hearing Detection and Intervention laws or voluntary participation compliance programs that screen hearing. Infants not passing the screening receive diagnostic evaluation before three months of age (as part of newborn screening short-term follow-up process) and, when necessary, are by six months of age, enrolled in early intervention programs (part of the long-term follow-up process). The goal of early hearing detection and intervention (EHDI) is to maximize lingusitic competence and literacy development for children who are deaf and hard of hearing. [Source: http://asha.org./advocacy/federal/ehdi/ ] hearing screening hearing test Hearing screening is a hearing assay with the objective to determine the presence or absence of hearing loss. Curation status: Incomplete ONSTR:ONSTR_7567208 Definition source: ONSTR curators percent adequate fatty acid intake datum Percent adequate fatty acid intake is a percent adequate macronutrient intake that provides the information about the quantity of specific dietary fatty acid consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for the observed fatty acid. Curation status: Incomplete ONSTR:ONSTR_7588725 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.362-370. low average daily dietary phosphorus intake low mean phosphorus intake low phosphorus intake Low average daily dietary phosphorus intake is an average daily dietary phosphorus intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary phosphorus for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7594457 Definition source: ONSTR curators. long-term follow-up patient data collection Long-term follow-up patient data collection is a data collection consisting of all the data collected during all the long-term follow-up visits of all patients. Curation status: Incomplete ONSTR:ONSTR_7594857 Definition source: ONSTR curators. estimated average nutrient requirement for pregnant female population Estimated average nutrient requirement for pregnant female is an estimated average nutrient requirement for female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of population of pregnant females. Curation status: Incomplete ONSTR:ONSTR_7595557 Definition source: ONSTR curators percent dietary reference intake datum percent DRI Percent dietary reference intake datum is a scalar measurement datum that provides the information about the quantity of specific dietary nutrient consumed (or to be consumed) by a human, that is expressed as a percentage of the dietary reference intake (DRI) for the observed nutrient. Curation status: Incomplete ONSTR:ONSTR_7599170 Definition source: ONSTR curators. kidney epithelial cell lacking phenylalanine-4-hydroxylase complex Kidney epithelial cell lacking phenylalanine-4-hydroxylase complex is a kidney epithelial cell that due to alteration(s) in the PAH gene completely lacks the phenylalanine-4-hydroxylase protein and/or phenylalanine-4-hydroxylase complex. Curation status: Incomplete ONSTR:ONSTR_7608290 Definition source: ONSTR curators. adequate nutrient intake for female population age 70 years and older Adequate nutrient intake for female population age 70 years and older is an adequate nutrient intake for non-pregnant non-lactating female population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy female population age 70 years and older. Curation status: Incomplete ONSTR:ONSTR_7616347 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.202-210. normal average daily dietary vitamin C intake normal mean vitamin C intake normal vitamin C intake Normal average daily dietary vitamin C intake is an average daily dietary vitamin C intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) or between the values of recommended dietary allowance (DRI-RDA) for dietary vitamin C for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7622495 Definition source: ONSTR curators percent adequate biotine intake datum Percent adequate biotine intake is a percent adequate vitamin intake that provides the information about the quantity of biotine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for biotine. Curation status: Incomplete ONSTR:ONSTR_7624772 Definition source: ONSTR curators. percent recommended dietary cysteine allowance Percent recommended dietary cysteine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary cysteine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid cysteine. Curation status: Incomplete ONSTR:ONSTR_7626463 Definition source: ONSTR curators. estimated average nutrient requirement for female population age 9-to-13 years Estimated average nutrient requirement for female population age 9-to-13 years is an estimated average nutrient requirement for non-pregnant non-lactating female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of female population of 9 to 13 years of age. Curation status: Incomplete ONSTR:ONSTR_7629801 Definition source: ONSTR curators. tolerable organic acid intake datum organic acid intake tolerance organic acid tolerance Tolerable organic acid intake datum is a tolerable nutrient intake datum that provides the information about quantity of a particular organic acid that a patient can consume enterally or parenterally during the 24 hours time interval, such that the value of the concentration of the observed organic acid in a bodily fluid (usually blood or urine) measured after the observed 24 hours falls within the therapeutic range for that particular organic acid. Curation status: Incomplete ONSTR:ONSTR_7644562 Definition source: ONSTR curators. blood amino-acid concentration therapeutic range datum Blood amino-acid concentration therapeutic range datum is a blood chemical concentration therapeutic range datum that provides the information about the set of values (limited by the minimal and maximal values) of blood concentration measurements of an observed amino-acid, such that the amino-acid concentration values falling within this range do not produce or produce minimal toxic effects to most of the members of the observed population. Curation status: Incomplete ONSTR:ONSTR_7646124 Definition source: ONSTR curators. whole blood leucine concentration measurement datum blood Leu concentration blood Leu level blood Leu status blood leucine concentration blood leucine level blood leucine measurement blood leucine status Whole blood leucine concentration measurement datum is a whole blood amino-acid concentration measurement datum that provides the information about the quantity of amino-acid leucine in the human blood specimen (or blood eluate derived from the dried blood spot specimen) that has been collected from patient at least 2.5 or 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_7654391 Definition source: ONSTR curators. blood serum transthyretin concentration measurement datum blood (serum) prealbumin measurement datum blood serum TTR measurement datum serum TTR concentration serum TTR level serum transthyretin concentration Blood serum transthyretin concentration measurement datum is a concentration measurement datum that is the output of the transthyretin measurement assay that measures the concentration of transthyretine (pre-albumin) in human blood. Curation status: Incomplete ONSTR:ONSTR_7655333 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.202-210. high average daily dietary vitamin C intake high mean vitamin C intake high vitamin C intake High average daily dietary vitamin C intake is an average daily dietary vitamin C intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) or between the values of recommended dietary allowance (DRI-RDA) for dietary vitamin C for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7664189 Definition source: ONSTR curators. body height measurement datum body length height height measurement length length measurement stature stature measurement Body height measurement datum is a length measurement datum that is the result of the body height measurement assay. Curation status: Incomplete ONSTR:ONSTR_7675407 Definition source: ONSTR curators. upper tolerable nutrient intake level for infant population age 0-to-6 months Upper tolerable nutrient intake level for infant population age 0-to-6 months is an upper tolerable nutrient intake level for infant population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy infant population 0 to 6 months of age. Curation status: Incomplete ONSTR:ONSTR_7676093 Definition source: ONSTR curators. newborn screening finding NBS finding Newborn screening finding is a clinical finding and that is an output of newborn screening result interpretation of one or more newborn screening tests (pulse oximetry, hearing screening and newborn dried blood spot screening). Curation status: Incomplete ONSTR:ONSTR_7691352 Definition source: ONSTR curators. average daily dietary folacin intake per body mass during observed time interval Average daily dietary folacin intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of folacin contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7714134 Definition source: ONSTR curators. role of a chemical entity in a biochemical reaction Role of a chemical entity in a biochemical reactions is a role borne by a chemical entity that is not an enzyme and that may participate in various biochemical reactions. Curation status: Incomplete ONSTR:ONSTR_7730971 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. normal average daily dietary tryptophan intake normal mean tryptophan intake normal tryptophan intake Normal average daily dietary tryptophan intake is an average daily dietary histidine intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary tryptophan for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7731715 Definition source: ONSTR curators. recommended dietary allowance percentage %RDA Recommended dietary allowance percentage is a dietary reference intake percentage unit (dimensionless unit) which denotes the quantity of a dietary nutrient that may be (or has been) consumed by a human as a percentage of the recommended dietary allowance for that specific nutrient. Curation status: Incomplete ONSTR:ONSTR_7733244 Definition source: ONSTR curators. average daily dietary arachidonic acid intake during observed time interval average daily ArA intake daily ArA intake mean ArA intake Average daily dietary arachidonic acid intake over observed time interval datum is an average daily dietary fatty acid intake during observed time interval denoting the average quantity of arachidonic acid (ArA) contained in all nutriotional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_7734161 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 328-339. low average daily dietary magnesium intake low magnesium intake low mean magnesium intake Low average daily- dietary magnesium intake is an average daily dietary magnesium intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary magnesium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7742892 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 156-166. high average daily total dietary water intake high daily water intake high mean water intake high water intake High average daily dietary water intake is an average daily total dietary water intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for total dietary water for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7743924 Definition source: ONSTR curators percent upper tolerable vitamin K intake level datum Percent upper tolerable vitamin K intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of vitamin K consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for vitamin K. Curation status: Incomplete ONSTR:ONSTR_7762559 Definition source: ONSTR curators. average daily dietary sodium intake per body mass during observed time interval Average daily dietary sodium intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary sodium contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7772837 Definition source: ONSTR curators. average daily dietary choline intake per body mass during observed time interval Average daily dietary choline intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of choline contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7773980 Definition source: ONSTR curators. average daily total dietary fiber intake during observed time interval mean fiber intake Average daily total dietary fiber intake over observed time interval datum is an average daily dietary macronutrient intake during observed time interval denoting the average intake of dietary fibers contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days or three days). Curation status: Incomplete ONSTR:ONSTR_7804317 Definition source: The United States Code, 2006 Edition, Supplement 4, Title 21 - Food and Drugs. Subchapter II - Definitions, Section 321 - Infant formulas, pp. 34. [Retrievable from http://gpo.gov ] infant formula formula milk infant milk formula standard infant formula Infant formula is a nutritional formula which purports to be or is represented for special dietary usage solely as food for infants by reason of its simulation of human milk or its suitability as a complete or partial substitute for human milk. Curation status: Incomplete ONSTR:ONSTR_7814731 Definition source: ONSTR curators percent upper tolerable phenylalanine intake level datum Percent upper tolerable phenylalanine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid phenylalanine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for phenylalanine. Curation status: Incomplete ONSTR:ONSTR_7819287 Definition source: ONSTR curators. Definition source: http://en.wikipedia.org/wiki/Serum_iron total serum iron concentration measurement datum serum iron serum iron level total serum iron Total serum iron concentration measurement datum is a blood chemical concentration measurement datum that provides the information about the total concentration of iron in the observed blood serum specimen, that includes iron circulating in the blood and iron bound to transferrin (serotransferin). Curation status: Incomplete ONSTR:ONSTR_7843044 Definition source: Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.62-64. mutant phenylalanine 4-monooxygenase genotype mutant PAH genotype mutant phenylalanine hydroxylase genotype A PAH genotype that includes two mutated (mutant) alleles coding for enzyme phenylalanine hydroxylase monomer (PAH monomer). Curation status: Incomplete ONSTR:ONSTR_7852198 Definition source: ONSTR curators. average daily dietary methionine intake per body mass during observed time interval Average daily methionine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid methionine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7853973 Definition source: ONSTR curators. percent recommended dietary vitamin B12 allowance Percent recommended dietary vitamin B12 allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary vitamin B12 consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for vitamin B12. Curation status: Incomplete ONSTR:ONSTR_7867655 Definition source: http://pediatrics.about.com/cs/growthcharts2/a/percentiles.htm developmental growth indicator developmental growth percentile growth centile growth percentile Developmental growth indicator is a data item that is an approximated percentile associated with the value of a measured phenotypical quality, and which is used as clinical indicator to assess the magnitude and pattern of developmental growth of individual child being assessed. Estimated percentile provides the information of how given phenotypic quality measurement datum of a child being assessed, compares to that of the age and sex specific reference population. Curation status: Incomplete ONSTR:ONSTR_7877066 Definition source: ONSTR curators percent adequate threonine intake datum Percent adequate threonine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid threonine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for threonine. Curation status: Incomplete ONSTR:ONSTR_7882695 Definition source: http://medical-dictionary.thefreedictionary.com/therapeutic+range urine chemical concentration therapeutic range datum Urine chemical concentration therapeutic range datum is a therapeutic range datum providing the information about the set of values (limited by the minimal and maximal values) of the concentration of particular chemical in the urine, such that the concentration values falling within this range do not produce or produce minimal toxic effects to most of the members of the observed population. Curation status: Incomplete ONSTR:ONSTR_7890764 Definition source: ONSTR curators. performing disease confirmatory diagnosis Performing disease confirmatory diagnosis is a performing a diagnosis that realizes the clinical geneticist role and that has the output confirmatory diagnosis for a particular inherited metabolic disease. Curation status: Incomplete ONSTR:ONSTR_7891915 Definition source: ONSTR curators. blood carnitine ester concentration measurement datum blood acyl-cartnitine concentration Blood carnitine ester concentration measurement datum is a blood chemical concentration measurement datum that provides the information about the quantity of a particular carnitine ester in the human blood eluate or whole blood specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_7908293 Definition source: ONSTR curators volume per unit mass per unit time Volume per unit mass per unit time is a dietary nutrient intake per unit time that is a measure of the number of volume units of a particular nutrient taken by a human in time interval, with respect to human body mass. Curation status: Incomplete ONSTR:ONSTR_7909999 Definition source: http://www.cdc.gov/growthcharts/clinical_charts.htm boys 2-to-20 years stature-for-age weight-for-age percentile chart 2 to 20 years: Boys, stature-for-age and weight-for-age percentiles boys stature-for-age and weight-for-age percentile boys stature-for-age and weight-for-age percentiles Boys 2-to-20 years stature-for-age weight-for-age percentile chart is a 2-to-20 years stature-for-age weight-for-age percentile chart that illustrates the distributions of height and weight measurement data with respect to age in a population of healthy boys 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_7910567 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 122-139. low average daily total dietary fat intake low daily fat intake low fat intake low mean fat intake Low average daily total dietary fat intake is an average daily total dietary fat intake during observed time interval that has value less than that of the adequate intake (DRI-AI) for total dietary fat intake for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_7916081 Definition source: ONSTR curators. average daily dietary sulfate intake per body mass during observed time interval Average daily dietary sulfate intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of all dietary sulfates combined and contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7920062 Definition source: ONSTR curators. estimated average nutrient requirement for pregnant female population age 14-to-18 years Estimated average nutrient requirement for pregnant female population age 14-to-18 years is an estimated average nutrient requirement for pregnant female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of population of pregnant females 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_7920668 Definition source: ONSTR curators. blood fatty acid concentration ratio datum Blood fatty acid concentration ratio datum is a blood chemical concentration ratio datum that provides the information about the ratio of concentrations of clinically relevant fatty acids in the blood. Curation status: Incomplete ONSTR:ONSTR_7924273 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. high average daily dietary intake of methionine and cysteine combined High average daily dietary intake of methionine and cysteine combined is an average daily dietary intake during observed time interval of methionine and cysteine combined that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary methionine and cysteine combined for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_7928270 Definition source: ONSTR curators percent upper tolerable docosahexaenoic acid intake level datum Percent upper tolerable docosahexaenoic acid intake level is a percent upper tolerable fatty acid intake level that provides the information about the quantity of docosahexaenoic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for docosahexaenoic acid. Curation status: Incomplete ONSTR:ONSTR_7934212 Definition source: ONSTR curators. blood organic acid concentration therapeutic range datum Blood organic acid concentration therapeutic range datum is a blood chemical concentration therapeutic range datum that provides the information about the set of values (limited by the minimal and maximal values) of blood concentration measurements of the observed organic acid, such that the organic acid concentration values falling within this range do not produce or produce minimal toxic effects to most of the members of the observed population. Curation status: Incomplete ONSTR:ONSTR_7962056 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 girls birth-to-36-months length-for-age percentile chart Length-for-age percentiles: Girls, birth to 36 months girls length-for-age birth to 36 months percentile chart Girls birth-to-36-months length-for-age percentile chart is a birth-to-36-months length-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of height measurement data (body height measurements) with respect to age in a population of healthy girls 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_7967727 Definition source: ONSTR curators percent upper tolerable vitamin A intake level datum Percent upper tolerable vitamin A intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of vitamin A consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for vitamin A. Curation status: Incomplete ONSTR:ONSTR_7975878 Definition source: ONSTR curators. hepatocyte containing defective phenylalanine-4-hydroxylase complex Hepatocyte containing defective phenylalanine-4-hydroxylase complex is a disordered hepatocyte that contains defective phenylalanine-4-hydroxylase complex or defective phenylalanine-4-hydroxylase protein (i.e. PAH enzyme monomer). Curation status: Incomplete ONSTR:ONSTR_7976521 Definition source: ONSTR curators. average daily dietary chromium intake per body mass during observed time interval Average daily dietary chromium intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary chromium contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_7976727 Definition source: ONSTR curators. tolerable phenylalanine intake datum Phe tolerance phenylalanine intake tolerance phenylalanine tolerance Tolerable phenylalanine intake datum is a tolerable amino-acid intake datum that provides the information about quantity of phenyalalnine that a patient can consume enterally or parenterally during the 24 hours time interval, such that the value of the concentration of phenylalanine in the blood measured after the observed 24 hours falls within the therapeutic range for blood phenylalanine. Curation status: Incomplete ONSTR:ONSTR_7984099 Definition source: ONSTR curators percent estimated average methionine requirement datum Percent estimated average methionine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid methionine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for methionine. Curation status: Incomplete ONSTR:ONSTR_7991777 Definition source: ONSTR curators percent estimated average thiamine requirement datum Percent estimated average thiamine requirement is a percent estimated average vitamin requirement that provides the information about the quantity of thiamine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for thiamine. Curation status: Incomplete ONSTR:ONSTR_7999431 Definition source: ONSTR curators percent upper tolerable glutamic acid intake level datum Percent upper tolerable glutamic acid intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of glutamic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for glutamic acid. Curation status: Incomplete ONSTR:ONSTR_8007479 Definition source: ONSTR curators percent estimated average magnesium requirement datum Percent estimated average magnesium requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of magnesium consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for magnesium. Curation status: Incomplete ONSTR:ONSTR_8036786 Definition source: ONSTR curators percent upper tolerable glutamine intake level datum Percent upper tolerable glutamine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid glutamine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for glutamine. Curation status: Incomplete ONSTR:ONSTR_8047878 Definition source: ONSTR curators. percent recommended dietary sulfate allowance Percent recommended dietary sulfate allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary sulfate consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for sulfate. Curation status: Incomplete ONSTR:ONSTR_8054494 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp.218-223. normal average daily dietary choline intake normal choline intake normal mean choline intake Normal average daily dietary choline intake is an average daily dietary choline intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary choline for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8056037 Definition source: ONSTR curators. percent recommended dietary folacin allowance Percent recommended dietary folacin allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary folacin consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for folacin. Curation status: Incomplete ONSTR:ONSTR_8057933 Definition source: ONSTR curators. normal phenylalanine-4-hydroxylase activity Normal phenylalanine-4-hydroxylase activity is a phenylalanine-4-hydroxylase activity that under normal physiological conditions (normal cytosolic pH, temperature and substrate saturation)catalyses the conversion of L-phenyalalanine to L-tyrosine at catalytic rate that is considered normal for phenylalanine-4-hydroxylase complex. Curation status: Incomplete ONSTR:ONSTR_8059146 Definition source: http://purl.bioontology.org/ontology/MSH/D005865 gestational age at birth Gestational age at birth is human age based on the amount of time the conceptus (human foetus) has spent in utero, measured from the estimated time of conception/fertilizatiuon until birth (i.e. the time point at which a foetus becomes a neonate). Curation status: Incomplete ONSTR:ONSTR_8059576 Definition source: ONSTR curators. dried blood spot specimen creation objective Dried blood spot specimen creation objective is a blood specimen creation objective to create a dried blood specimen of a portion of blood (usually capillary or venous) for the purposes of conserving the blood specimen to be used in investigation at a later date. Curation status: Incomplete ONSTR:ONSTR_8076467 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.320-326. low average daily dietary iodine intake low iodine intake low mean iodine intake Low average daily dietary iodine intake is an average daily dietary iodine intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary iodine for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8080880 Definition source: ONSTR curators. percent recommended dietary vitamin D allowance Percent recommended dietary vitamin D allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary vitamin D consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for vitamin D. Curation status: Incomplete ONSTR:ONSTR_8083622 Definition source: Rodwell W., S. (1989) Nutrition and diet therapy. 6th Ed. Times Mirror/Mosby College Publishing. St. Luis, MO, pp.5. macronutrient Macronutrient is a nutrient that introduced into human body in large amounts and serves to produce energy and build body tissues. Curation status: Incomplete ONSTR:ONSTR_8084788 Definition source: ONSTR curators. age at third newborn dried blood spot specimen collection measurement datum age at third DBS collection Age at third newborn screening dried blood spot specimen collection measurement datum is age repeated newborn screening dried blood spot collection measurement datum that is the result of measurement of time elapsed from birth of the neonate until the instant of the second newborn screening dried blood spot specimen collection. Curation status: Incomplete ONSTR:ONSTR_8085813 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp.234-243. normal average daily dietary vitamin E intake normal mean vitamin E intake normal vitamin E intake Normal average daily dietary vitamin E intake is an average daily dietary vitamin E intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary vitamin E for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8088394 Definition source: ONSTR curators percent upper tolerable tyrosine intake level datum Percent upper tolerable tyrosine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid tyrosine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for tyrosine. Curation status: Incomplete ONSTR:ONSTR_8098791 Definition source: ONSTR curators percent upper tolerable amino-acid intake level datum Percent upper tolerable amino-acid intake level is a percent upper tolerable macronutrient intake level that provides the information about the quantity of specific amino-acid consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for the observed amino-acid. Curation status: Incomplete ONSTR:ONSTR_8115283 Definition source: ONSTR curators percent adequate arginine intake datum Percent adequate arginine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid arginine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for arginine. Curation status: Incomplete ONSTR:ONSTR_8119284 Definition source: ONSTR curators percent estimated average vanadium requirement datum Percent estimated average vanadium requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of vanadium consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for vanadium. Curation status: Incomplete ONSTR:ONSTR_8130450 Definition source: ONSTR curators. venous blood specimen creation measurement datum Venous blood specimen creation measurement datum is a specimen creation measurement datum that provides the information about the time the venous blood specimen have been created. Curation status: Incomplete ONSTR:ONSTR_8153913 Definition source: ONSTR curators. average daily dietary intake during observed time interval of methionine and cysteine combined Average daily dietary intake during observed time interval of methionine and cysteine combined is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acids methionine and cysteine combined, contained in all food items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_8173437 Definition source: ONSTR curators. average daily dietary macronutrient intake per body mass during observed time interval Average daily dietary macronutrient intake per body mass during observed time interval is an average daily dietary nutrient intake per body mass during observed time interval information denoting the average quantity of a given macronutrient contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_8199142 Definition source: http://www.cdc.gov/growthcharts/charts.htm girls body mass index-for-age percentile clinical chart 2 to 20 years: Girls, Body mass index-for-age percentiles Girls body mass index-for-age percentile clinical chart is a body mass index-for-age percentile clinical chart that is a slight modification of the individual body mass index-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of body mass indices with respect to age in a population of healthy girls 2 to 20 years of age as well as the data entry tables and space for relevant patient information. Curation status: Incomplete ONSTR:ONSTR_8199564 Average daily dietary nutrient intake during observed time interval datum is a scalar that can be conceived and calculated as a grand average of all daily averages of the nutrient of interest. For instance, average daily total dietary protein intake during three day interval can be calculated as a grand average of the average daily dietary protein intakes for all three days of observation relevant for dietary analysis. Definition source: ONSTR curators. average daily dietary nutrient intake during observed time interval datum Average daily dietary nutrient intake over observed time interval datum is an average daily dietary nutrient intake datum denoting the average quantity of relevant nutrient contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days or three days). Curation status: Incomplete ONSTR:ONSTR_8201357 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. high average daily dietary lysine intake high lysine intake high mean lysine intake High average daily dietary lysine intake is an average daily dietary histidine intake during observed time interval that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary lysine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8208187 Definition source: ONSTR curators. average daily dietary alpha-linolenic acid intake during observed time interval average daily aLnA intake daily aLnA intake mean aLnA intake Average daily dietary alpha-linolenic acid intake over observed time interval datum is an average daily dietary fatty acid intake during observed time interval denoting the average quantity of alpha-linolenic acid (aLnA) contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_8214507 Definition source: http://www.esha.com/product/food-processor Definition source: http://www.esha.com/sites/default/files/documents/full_manual.pdf The Food Processor The Food Processor is a nutrient analysis software that is a commercial multi-platform program that provides a variety of analyses and printable reports in different file formats displaying different kind of diet related information such as nutrient content including fat and calorie percentage, food exchanges, food costs, comparison of food lists to nutrition goals, personalized recommended nutrient intakes and diet tracking. Curation status: Incomplete ONSTR:ONSTR_8219618 Definition source: ONSTR curators percent estimated average threonine requirement datum Percent estimated average threonine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid threonine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for threonine. Curation status: Incomplete ONSTR:ONSTR_8231823 Definition source: ONSTR curators percent upper tolerable arginine intake level datum Percent upper tolerable arginine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid arginine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for arginine. Curation status: Incomplete ONSTR:ONSTR_8235099 Definition source: ONSTR curators. Some of the processes unfolding during a patient long-term follow-up interval visit are: physical examination, nutrition assessment, psycho-cognitive development assessment, physical growth assessment etc. post dried blood spot screening long-term follow-up patient interval visit Post dried blood spot screening long-term follow-up patient interval visit is a health care process that realizes patient role, metabolic dietitian role and physician role and that consists of collection of health care processes unfolding on a regular basis during which a patient's overall growth and development (physical growth, physco-motor and psycho-cognitive development) is been examined, assessed and evaluated by various medical specialist and patient's therapy (nutrition and medication) evaluated and adjusted. Curation status: Incomplete ONSTR:ONSTR_8247791 Definition source: ONSTR curators. average daily dietary biotin intake per body mass during observed time interval Average daily dietary biotin intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of biotin contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_8248902 Definition source: ONSTR curators. adequate nutrient intake for population age 0-to-8 years Adequate nutrient intake for population age 0-to-8 years is an adequate nutrient intake datum that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy population 0 to 8 years of age. Curation status: Incomplete ONSTR:ONSTR_8256836 Definition source: ONSTR curators. prescribed nutritional item datum Prescribed nutritional item datum is a data item that provides the information about the kinds and quantities of nutritional items prescribed by a dietitian (or a physician) to be consumed by a human patient. Curation status: Incomplete ONSTR:ONSTR_8261866 Definition source: http://www.cdc.gov/growthcharts/charts.htm girls body mass index-for-age percentile chart Body mass index-for-age percentiles: Girls, 2 to 20 years girls BMI-for-age percentile chart girls body mass index-for-age percentile chart girls body mass index-for-age percentiles Girls body mass index-for-age percentile chart is a body mass index-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of body mass indices with respect to age in a population of healthy girls 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_8267476 Definition source: ONSTR curators. estimated average nutrient requirement for pregnant female population age 31-to-50 years Estimated average nutrient requirement for pregnant female population age 31-to-50 years is an estimated average nutrient requirement for pregnant female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of population of pregnant females 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_8271869 Definition source: ONSTR curators percent upper tolerable vitamin D intake level datum Percent upper tolerable vitamin D intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of vitamin D consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for vitamin D. Curation status: Incomplete ONSTR:ONSTR_8283208 Definition source: ONSTR curators percent estimated average vitamin E requirement datum Percent estimated average vitamin E requirement is a percent estimated average vitamin requirement that provides the information about the quantity of vitamin E consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for vitamin E. Curation status: Incomplete ONSTR:ONSTR_8290547 Definition source: ONSTR curators. body mass index-for-age percentile Body mass index (BMI) [Percentile] Body mass index-for-age percentile is a developmental growth indicator showing the percentage of children (in a reference population distribution) that are of the same age as the assessed child, and whose body mass index has equal or smaller value than that of the child being assessed at the time of given physical examination. Curation status: Incomplete ONSTR:ONSTR_8294453 Definition source: http://en.wikipedia.org/wiki/Height_of_a_human_being Definition source: http://purl.bioontology.org/ontology/MSH/D001827 In neonates and infants body height is commonly called length implying horizontal directionality. Since neonates and infants are unable to stand erect, the linear distance between the bottom of the feet to the top of the head is measured when neonate or infant is lying with legs fully extended. body height Body height is human body quality that inheres in human body by virtue of the linear distance between the sole (bottom of the feet) to the crown (top) of the head in human body standing or lying fully extended. Curation status: Incomplete ONSTR:ONSTR_8297986 Definition source: ONSTR curators. nutritional item intake data entry Nutritional item intake data entering is a planned process that realizes dietitian role and that consist of nutritional intake data conversion into digital form by typing on computer keyboard. Curation status: Incomplete ONSTR:ONSTR_8300260 Definition source: ONSTR curators. whole blood valine concentration measurement datum blood Val concentration blood Val level blood Val status blood valine concentration blood valine level blood valine measurement blood valine status Whole blood valine concentration measurement datum is a whole blood amino-acid concentration measurement datum that provides the information about the quantity of amino-acid valine in the human blood specimen (or blood eluate derived from the dried blood spot specimen) that has been collected from patient at least 2.5 or 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_8301532 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 122-139. high average daily total dietary fat intake high daily fat intake high fat intake high mean fat intake High average daily total dietary fat intake is an average daily total dietary fat intake during observed time interval that has value that is grater than that of the adequate intake (DRI-AI) for total dietary fat for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8313486 Definition source: ONSTR curators nutritional intake measurement datum Nutritional intake measurement datum is a scalar measurement datum providing the information about nutrients that are contained in or dietary energy derived from nutritional items a patient or study subject consumed or can consume during observed time interval relevant for nutrition assessment or nutrition monitoring. Curation status: Incomplete ONSTR:ONSTR_8313713 Definition source: ONSTR curators. upper tolerable nutrient intake level for lactating female population Upper tolerable nutrient intake level for lactating female population is an upper tolerable nutrient intake level for female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy lactating female population. Curation status: Incomplete 7.0 12.0 9.17 11.0 7.0 9.1 13.0 1.0 4.0 10.77 13.0 4.0 9.0 15.2 19.0 9.0 14.0 27.2 34.0 43.43 52.0 38.42 46.0 14.0 19.0 46.2 56.0 34.5 46.0 19.0 56.8 71.0 57.35 71.0 15.0 ONSTR:ONSTR_8315383 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 144-155. normal average daily total dietary protein intake normal daily protein intake normal mean protein intake normal protein intake Normal average daily dietary protein intake is an average daily total dietary protein intake during observed time interval that has value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to the recommended dietary allowance (DRI-RDA) for total dietary protein for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8315858 Definition source: ONSTR curators. cerebrospinal fluid chemical concentration measurement datum Cerebrospinal fluid chemical concentration measurement datum is a concentration measurement datum providing the information about the concentration of a observed chemical in the human cerebrospinal fluid specimen or processed cerebrospinal fluid specimen. Curation status: Incomplete ONSTR:ONSTR_8317750 Definition source: ONSTR curators percent upper tolerable protein intake level datum Percent upper tolerable protein intake level is a percent upper tolerable macronutrient intake level that provides the information about the total quantity of all proteins combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for (total) protein. Curation status: Incomplete ONSTR:ONSTR_8323231 Definition source: ONSTR curators. whole blood acetylcarnitine concentration measurement datum blood C2 concentration blood acetylcarnitine concentration whole blood C2 concentration whole blood acetylcarnitine concentration Whole blood acetylcarnitine concentration measurement datum is a whole blood carnitine ester concentration measurement datum that provides the information about the quantity of acetylcarnitine in the human blood eluate or whole blood specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_8327411 Definition source: ONSTR curators. age at confirmatory testing blood specimen collection measurement datum age at confirmatory testing Age at confirmatory testing blood specimen collection measurement datum is age since birth measurement datum that is the result of measurement of time elapsed from birth of the neonate until the instant when a portion of neonate blood is drawn for the purpose of using it in the inherited metabolic disorder specific confirmatory laboratory assays. Curation status: Incomplete ONSTR:ONSTR_8335262 Definition source: ONSTR curators. cerebrospinal fluid phenylalanine concentration finding Cerebrospinal fluid phenylalanine concentration finding is a phenylalanine concentration finding that is physician's interpretation of the value of cerebrospinal fluid phenylalanine concentration measurement datum, and that is based cerebrospinal fluid phenyalanine concentration reference value ranges established through clinical research. Curation status: Incomplete ONSTR:ONSTR_8336133 Definition source: ONSTR curators. This class fits better in OBI/IAO domain. However, since it is not presently asserted in OBI/IAO, and we need it, we are asserting it for the time being. If OBI/IAO asserts a suitable class, this one is going to be obsoleted and replaced by the prospective/convenient OBI/IAO class.) length measurement assay Length measurement assay is a measurement assay which determines the magnitude of linear distance between two points. Curation status: Incomplete ONSTR:ONSTR_8359675 Definition source: ONSTR curators. upper tolerable nutrient intake level for female population age 31-to-50 years Upper tolerable nutrient intake level for female population age 31-to-50 years is an upper tolerable nutrient intake level for non-pregnant non-lactating female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy female population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_8369223 Definition source: Hovasi Cox, J., Melbardis, I. M. (2005) Parenteral nutrition. In Handbook of pediatric nutrition, 3rd Ed. Jones and Bartlett publishers Inc. pp. 525-557. Definition source: O'Leary, E.,Wasseff, S. (1993) Pediatric parenteral nutrition support handobook. Nutrition support service, Egleston Children's Hospital, Emory University, Atlanta, GA, pp. 6-10. Definition source: http://en.wikipedia.org/wiki/Parenteral_nutrition parenteral amino-acid solution CAA solution parenteral CAA parenteral crystalline amino-acid solution Parenteral amino-acid solution is a parenteral nutrition solution that is composed of sterile water and crystalline amino-acids (essential and non-essential) in different concentrations depending on patient's needs. Curation status: Incomplete ONSTR:ONSTR_8377012 Definition source: ONSTR curators percent upper tolerable riboflavin intake level datum Percent upper tolerable riboflavin intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of riboflavin consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for riboflavin. Curation status: Incomplete ONSTR:ONSTR_8380725 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp. 122-139. normal average daily total dietary fat intake normal daily fat intake normal fat intake normal mean fat intake Normal average daily total dietary fat intake is an average daily total dietary fat intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for total dietary fat for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8384999 Definition source: ONSTR curators. upper tolerable nutrient intake level for lactating female population age 19-to-30 years Upper tolerable nutrient intake level for lactating female population age 19-to-30 years is an upper tolerable nutrient intake level for lactating female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy lactating female population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_8391545 Definition source: ONSTR curators percent adequate carbohydrate intake datum Percent adequate carbohydrate intake is a percent adequate macronutrient intake that provides the information about the total quantity of all carbohydrates combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for (total) carbohydrate. Curation status: Incomplete ONSTR:ONSTR_8417322 Definition source: ONSTR curators percent adequate chromium intake datum Percent adequate chromium intake is a percent adequate dietary mineral intake that provides the information about the quantity chromium consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for chromium. Curation status: Incomplete ONSTR:ONSTR_8433787 Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf newborn screening system long-term follow-up process LTFU NBS LTFU NBS-LTFU newborn screening system long-term follow-up Newborn screening system long-term follow-up process is a newborn screening follow-up system process that includes providing long-term condition-specific personalized treatment and disorder management, age-appropriate preventive care, continuous treatment quality improvement, engagement of affected individuals and their families as effective partners in care management etc. Curation status: Incomplete ONSTR:ONSTR_8437809 Definition source: ONSTR curators percent estimated average vitamin K requirement datum Percent estimated average vitamin K requirement is a percent estimated average vitamin requirement that provides the information about the quantity of vitamin K consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for vitamin K. Curation status: Incomplete ONSTR:ONSTR_8449792 Definition source: ONSTR curators. upper tolerable nutrient intake level for female population age 70 years and older Upper tolerable nutrient intake level for female population age 70 years and older is an upper tolerable nutrient intake level for non-pregnant non-lactating female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy female population age 70 years and older. Curation status: Incomplete ONSTR:ONSTR_8450180 Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf newborn screening system short-term follow-up process NBS STFU NBS-STFU STFU STFU process Newborn screening system short-term follow-up process is a newborn screening follow-up system process that includes activities that ensure that all infants are screened (repeated screen, as well as second and third tier testing completed), abnormal screen results appropriately and expediently reported to all interested parties (family or child caregiver, primary care physician etc.), affected infants promptly identified and located, appropriately referred and treatment initiated where needed and applicable. Curation status: Incomplete ONSTR:ONSTR_8454231 Definition source: ONSTR curators. Definition source: http://purl.org/obo/owl/GO#GO_0048589 developmental body growth Developmental body growth is developmental growth such that the increase in size and mass of the entire human body has the outcome of reaching adult body size and mass. Curation status: Incomplete ONSTR:ONSTR_8458226 Definition source: ONSTR curators percent upper tolerable vitamin E intake level datum Percent upper tolerable vitamin E intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of vitamin E consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for vitamin E. Curation status: Incomplete ONSTR:ONSTR_8461214 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source:[Source:[Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. normal average daily dietary isoleucine intake normal isoleucine intake normal mean isoleucine intake Normal average daily dietary isoleucine intake is an average daily dietary histidine intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary isoleucine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete 10.0 360.0 ONSTR:ONSTR_8464423 Definition source: ONSTR curators. PKU hyperphenylalaninemia finding PKU hyperphenylalaninemia finding is a hyperphenylalaninemia finding based on the value of blood phenylalanine concentration measurement datum or plasma phenylalanine concentration measurement datum greater than 360 μmol/L (10 mg/dL) for which it has been clinically established as being indicative of phenylketonuria (PKU). Curation status: Incomplete ONSTR:ONSTR_8468666 Definition source: ONSTR curators. average daily dietary tryptophan intake during observed time interval average daily dietary Trp intake daily Trp intake mean tryptophan intake Average daily tryptophan intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid tryptophan contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_8472949 Definition source: ONSTR curators percent upper tolerable zinc intake level datum Percent upper tolerable zinc intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of zinc consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for zinc. Curation status: Incomplete ONSTR:ONSTR_8484144 Definition source: http://www.cdc.gov/growthcharts/charts.htm girls birth-to-36 months weight-for-length percentile chart Weight-for-length percentiles: Girls, birth to 36 months girls weight-for-length percentile chart girls weight-for-length percentiles Girls birth-to-36 months weight-for-length percentile chart is a birth-to-36 months weight-for-height percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of weight measurement data (body mass measurements) with respect to height measurement data (body height measurements) in a population of healthy girls 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_8487474 Definition source: ONSTR curators. recommended dietary allowance for male population age 14-to-18 years Recommended dietary allowance for male population age 14-to-18 years is a recommended dietary allowance for male population denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy male population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_8527984 Definition source: ONSTR curators. average daily dietary alanine intake during observed time interval average daily dietary Ala intake daily Ala intake Average daily alanine intake during observed time interval is an average daily dietary amino acid intake during observed time interval denoting the average quantity of amino-acid alanine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_8528154 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. high average daily dietary valine intake high mean valine intake high valine intake High average daily dietary valine intake is an average daily dietary histidine intake during observed time interval that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary valine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8528184 Definition source: ONSTR curators. normal phenylalanine-4-hydroxylase Normal phenylalanine-4-hydroxylase is a phenylalanine-4-hydroxylase (protein) whose primary, secondary and tertiary structure does not have any abnormal alterations. Curation status: Incomplete ONSTR:ONSTR_8529802 Definition source: ONSTR curators. body mass index-for-age percentile derivation BMI-for-age percentile derivation Body mass index-for-age percentile derivation is developmental growth indicator derivation with the goal to determine (or give best possible approximation of) body mass index-for-age percentile for given child, at the time of physical examination. In order to derive body mass index-for-age percentile information, child's body mass index and age are plotted with respect to the body mass index and age scales of the age and sex appropriate body mass index-for-age percentile growth chart; the position of the resulting point is then compared with the closest body mass index-for-age percentile curves comprising the body mass index-for-age growth chart; body mass index-for-age percentile is then determined (or maximally approximated) based on the closest percentile curve. Curation status: Incomplete ONSTR:ONSTR_8560387 Definition source: http://en.wikipedia.org/wiki/Cardiology pediatric cardiologist role Pediatric cardiologist role is a physician role that is realized during processes of providing heart related health care to newborns such as identifying, diagnosing, treating and monitoring of congenital heart disorders, coronary artery disease, heart failure, valvular heart diseases and electrophysiology. Curation status: Incomplete. ONSTR:ONSTR_8561254 Definition source: ONSTR curators percent estimated average selenium requirement datum Percent estimated average selenium requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of selenium consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for selenium. Curation status: Incomplete ONSTR:ONSTR_8561539 Definition source: http://www.ncc.umn.edu/products/ndsr.html Nutrition Data System for Research NDSR Nutrition Data System for Research is a nutrient analysis software that is the commercial Windows operating system based program for the collection and analyses of dietary records, recipes, menus and that provides the data per food ingredient, food item, meal and day, in report and analytical formats. Curation status: Incomplete ONSTR:ONSTR_8579471 Definition source: ONSTR curators. upper tolerable nutrient intake level for non-pregnant non-lactating female population Upper tolerable nutrient intake level for non-pregnant non-lactating female population is an upper tolerable nutrient intake level for female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of population of healthy non-pregnant non-lactating females. Curation status: Incomplete ONSTR:ONSTR_8585910 Definition source: ONSTR curators. recommended dietary allowance for female population age 19-to-30 years recommended dietary allowance for lactating female population age 19-to-30 years Recommended dietary allowance for female population age 19-to-30 years is a recommended dietary allowance for non-pregnant non-lactating female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy female population 19 to 30 years of age. Recommended dietary allowance for lactating female population age 19-to-30 years is a recommended dietary allowance for lactating female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of lactating healthy female population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_8588243 Definition source: ONSTR curators. average daily dietary thiamine intake per body mass during observed time interval Average daily dietary thiamine intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of thiamine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_8589294 Definition source: ONSTR curators percent adequate serine intake datum Percent adequate serine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid serine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for serine. Curation status: Incomplete ONSTR:ONSTR_8601363 Body mass index-for-age percentile clinical charts are available only for children and adolescents age 2 to 20 years, but not other age groups (birth to 36 months and 2 to 5 years). Definition source: http://www.cdc.gov/growthcharts/charts.htm body mass index-for-age percentile clinical chart BMI-for-age percentile clinical chart Body mass index-for-age percentile clinical chart is a CDC clinical growth chart that is a slight modification of the individual body mass index-for-age percentile chart and consists of smoothed percentile curves illustrating the distribution(s) of body mass indices with respect to age in a population of healthy children and adolescents 2 to 20 years of age, and the data entry tables and spaces for patient relevant information. Curation status: Incomplete ONSTR:ONSTR_8607229 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. low average daily dietary intake of methionine and cysteine combined Low average daily dietary intake of methionine and cysteine combined is an average daily dietary intake during observed time interval of methionine and cysteine combined that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary methionine and cysteine combined for the population corresponding to patient's sex and age. Curation status: Incomplete ONSTR:ONSTR_8620755 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp.328-339. normal average daily dietary iron intake normal iron intake normal mean iron intake Normal average daily dietary iron intake is an average daily dietary iron intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary iron for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8632143 Definition source: ONSTR curators percent adequate lysine intake datum Percent adequate lysine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino acid lysine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for lysine. Curation status: Incomplete ONSTR:ONSTR_8689857 Definition source: ONSTR curators. average daily dietary vitamin intake per body mass during observed time interval Average daily dietary vitamin intake per body mass during observed time interval is an average daily dietary micronutrient intake per body mass during observed time interval information denoting the average quantity of a given vitamin contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_8707579 Definition source: Makola, D. (2005) Elemental and Semi-Elemental Formulas: Are They Superior to Polymeric Formulas? In Practical Gastroenterology, December 2005. elemental formula elemental monomeric formula Elemental formula is a nutritional formula that contains individual amino-acids, glucose polymers, and have low fat content (with only about 2% to 3% of calories derived from long chain triglycerides). Curation status: Incomplete ONSTR:ONSTR_8717650 Definition source: http://britannica.com/EBchecked/topic/409243/nephelometry-and-turbidimetry Definition source: http://en.wikipedia.org/wiki/Nephelometry_(medicine) Definition source: http://medical-dictionary.thefreedictionary.com/nephelometry nephelometry Nephelometry is an assay of measuring the concentration of certain proteins in bodily fluids, that is performed by passing light through the prepared specimen and measuring the amount of scattering of collected light (passed through the specimen) at an angle (usually 30° or 90°), and that is based on the tendency of observed proteins to scatter light at identifiable angles. Curation status: Incomplete This calss may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). 7.0 12.0 1.2 7.0 2.2 1.0 4.0 1.05 14.0 19.0 0.85 4.0 14.0 0.95 19.0 0.8 1.1 1.3 15.0 ONSTR:ONSTR_8720247 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.144-155. high average daily total dietary protein intake per body mass High average daily total dietary protein per body mass is an average daily total protein intake per body mass during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA for total dietary protein per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8741124 Definition source: ONSTR curators. average daily dietary pantothenic acid intake during observed time interval daily dietary pantothenate intake daily dietary pantothenic acid intake daily dietary vitamin B5 intake daily vitamin B5 intake mean pantothenic acid intake Average daily dietary pantothenic acid intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of pantothenic acid contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_8744038 Definition source: ONSTR curators percent upper tolerable dietary fiber intake level datum Percent upper tolerable dietary fiber intake level is a percent upper tolerable macronutrient intake level that provides the information about the total quantity of all dietary fibers combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for (total) dietary fiber. Curation status: Incomplete ONSTR:ONSTR_8752766 Definition source: ONSTR curators. estimated average nutrient requirement for female population age 70 years and older Estimated average nutrient requirement for female population age 70 years and older is an estimated average nutrient requirement for non-pregnant non-lactating female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of female population of 70 years of age and older. Curation status: Incomplete 7.0 12.0 34.0 7.0 73.0 1.0 4.0 24.0 19.0 16.0 14.0 19.0 9.0 14.0 18.0 4.0 9.0 9.0 14.0 19.0 14.0 19.0 17.0 21.0 24.0 15.0 ONSTR:ONSTR_8759808 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] low average daily dietary threonine intake per body mass Low average daily dietary threonine per body mass is an average daily threonine intake per body mass during observed that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for dietary threonine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8762724 Definition source: ONSTR curators. body mass measurement datum body mass body weight weight Body mass measurement datum is mass measurement datum that is the result (specified output of) mass measurement of human body. Curation status: Incomplete ONSTR:ONSTR_8764887 Definition source: ONSTR curators. blood zinc concentration measurement datum blood zinc blood zinc level blood zinc measurement plasma zinc serum zinc Blood zinc concentration measurement datum is a blood chemical concentration measurement datum providing the information about the concentration of zinc in the blood plasma or serum specimen. Curation status: Incomplete ONSTR:ONSTR_8766901 Definition source: ONSTR curators. adequate nutrient intake for lactating female population age 31-to-50 years Adequate nutrient intake for lactating female population age 31-to-50 years is an adequate nutrient intake for lactating population that that denotes the average daily intake of a nutrient based on the observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy lactating female population 31 to 50 years of age. Curation status: Incomplete 7.0 12.0 43.0 7.0 59.0 1.0 4.0 28.0 14.0 19.0 9.0 14.0 21.0 14.0 19.0 19.0 19.0 4.0 9.0 9.0 14.0 22.0 25.0 26.0 15.0 ONSTR:ONSTR_8769256 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. high average daily dietary intake per body mass of methionine and cysteine combined High average daily dietary intake per body mass of methionine and cysteine combined is an average daily dietary intake per body mass of methionine and cysteine combined that has value that is greater than that of the recommended dietary allowance (DRI-RDA) for dietary methionine and cysteine combined per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8770782 Definition source: http://asha.org./public/hearing/Hearing-Screening-and-Hearing-Evaluation/ hearing evaluation audiological evaluation Hearing evaluation is a hearing assay that is an in-depth assessment of an individual's hearing with the objective to deteremine the nature and the degree of hearing loss and the best treatment options. Hearing evaluation is usually performed by a qualified audiologist using a number of different methods and tests. Curation status: Incomplete ONSTR:ONSTR_8777352 Definition source: ONSTR curators. average daily dietary fatty acid intake during observed time interval Average daily dietary fatty acid intake over observed time interval datum is an average daily dietary macronutrient intake during observed time interval denoting the average intake of dietary fatty acids contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days or three days). Curation status: Incomplete 7.0 12.0 62.0 7.0 103.0 1.0 4.0 45.0 19.0 31.0 14.0 19.0 9.0 14.0 35.0 4.0 9.0 9.0 14.0 37.0 14.0 19.0 32.0 41.0 42.0 15.0 ONSTR:ONSTR_8803885 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] low average daily dietary lysine intake per body mass Low average daily dietary lysine per body mass is an average daily lysine intake per body mass during observed that has value that is less than that of the adequate intake (DRI-AI) or the estimated average requirement (DRI-EAR) for dietary lysine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8825392 Definition source: http://www.cdc.gov/growthcharts/charts.htm boys head circumference-for-age percentile chart Head circumference-for-age percentiles: Boys, birth to 36 months boys head circumference-for-age percentile chart boys head circumference-for-age percentiles Boys head circumference-for-age percentile chart is a head circumference-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of head circumference measurement data (head circumference measurements) with respect to age in a population of healthy boys 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_8851246 Definition source: ONSTR curators percent upper tolerable niacin intake level datum Percent upper tolerable niacin intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of niacin consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for niacin. Curation status: Incomplete ONSTR:ONSTR_8851283 Definition source: ONSTR curators. percent daily energy intake from alpha-linolenic acid percent daily energy from alpha-linolenic acid percent energy from alpha-linolenic acid Percent daily energy intake from alpha-linoleic acid is a percent daily dietary energy intake providing the information about the quantity of energy derived from total amount of alpha-linolenic acid taken by a patient (enterally or parenterally) during the 24 hour time interval, and expressed as a percentage of the total dietary energy intake. Curation status: Incomplete ONSTR:ONSTR_8862351 Definition source: ONSTR curators. average daily dietary leucine intake per body mass during observed time interval Average daily leucine intake per body mass during observed time interval is an average daily dietary amino-acid intake per body mass during observed time interval information denoting the average quantity of amino-acid leucine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_8862794 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 girls 2-to-20-years stature-for-age percentile chart Height-for-age percentiles: Girls, 2 to 20 years Stature-for-age percentiles: Girls, 2 to 20 years girls height-for-age 2 to 20 years percentile chart girls stature-for-age 2 to 20 years percentile chart Girls 2-to-20-years stature-for-age percentile chart is a 2-to-20-years stature-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of height measurement data (body height measurements) with respect to age in a population of healthy girls 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_8870732 Definition source: ONSTR curators. recommended dietary allowance for pregnant female population age 31-to-50 years Recommended dietary allowance for pregnant female population age 31-to-50 years is a recommended dietary allowance for pregnant female population that denotes the the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy pregnant female population 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_8872549 Definition source: ONSTR curators percent estimated average arginine requirement datum Percent estimated average arginine requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of amino-acid arginine consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for arginine. Curation status: Incomplete ONSTR:ONSTR_8881263 Definition source: ONSTR curators. snack Snack is a meal usually eaten by a human sometime between breakfast or lunch, or lunch and dinner (supper). Curation status: Incomplete ONSTR:ONSTR_8918965 Definition source: http://itl.nist.gov/div898/handbook/prc/section2/prc252.htm Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Percentile Since percentiles have values between 0 and 100 (0<p<100), they split the set of ordered statistics into hundredths, whereby each percentile can be associated with one or more values (scores). [Source:http://itl.nist.gov/div898/handbook/prc/section2/prc252.htm] Percentiles associated with particular values can be computed directly from the existing scores (values) or they can be interpolated for values that do not actually exist in the given distribution. [SN2012-01-17]Currently, there seems to be no precise definition for percentile. There exists roughly two groups of definitions of percentile. According to one type of definitions, a percentile is a value/observation/score, e.g. "The pth percentile is a value, Y(p), such that at most (100p)% of the measurements are less than this value and at most 100(1- p)% are greater." [source: http://itl.nist.gov/div898/handbook/prc/section2/prc252.htm]. Yet another set of definitions says that a percentile is a number point, for instance "Any of 99 numbered points that divide an ordered set of scores into 100 parts each of which contains one-hundredth of the total." [source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Percentile]. The fist type of definitions is misleading, because a percentile is not a score/observation/value itself, but a number other than a score itself. The second type of definitions is incomplete because it only says that a percentile is some kind of number entity ("a number point") dividing an ordered set of scores, but fails to provide information that a particular "number point", is associated with a particular score/value/observation. Technically speaking, a percentile is an information content entity (a number) providing information about another information entity, that is, it is a number telling something about another number. The definition currently provided in the ONSTR, tries to capture all the relevant information about what a percentile is. It's definition and position in the ontology still needs to be vetted/corrected by a statistician (i.e. it may be moved under a class called number, yet to be asserted or imported.) percentile centile Percentile is a data item that is a number between 0 and 100 (0 and 100 excluded), that is associated with an ordered statistic (i.e. a value, a score, an observation) in a sample distribution of independent random variables that are placed in ascending order) and refers to the position (numerical position, location) of a particular order statistic (i.e. value, score, observation) in a distribution of ordered statistics, such that it divides the ordered statistics into two groups of values/scores, a groups of values that are smaller and/or equal to a given value, and the group of values (scores) that are greater than given value. Curation status: Incomplete If for value/score 340 it is said that it is 77th percentile of a sample of random numbers from 1 to 400, then 77% of all give scores will be below (or maximally equal to) 34. Note: In common statistical parlance it is usually and misleadingly said that "a given score is a some (n-th) percentile of the given distribution". The fact is that given percentile always comes from a fixed set of numbers ranging from 1 to 99, and is not a score of given distribution which depends on the distribution itself. ONSTR:ONSTR_8923831 Definition source: ONSTR curators percent upper tolerable boron intake level datum Percent upper tolerable boron intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of boron consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for boron. Curation status: Incomplete ONSTR:ONSTR_8952813 Definition source: ONSTR curators. average daily dietary boron intake during observed time interval average B intake daily boron intake Average daily dietary boron intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary boron contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_8953989 Definition source: ONSTR curators. percent recommended dietary fat allowance Percent recommended dietary fat allowance is a percent recommended dietary macronutrient allowance that provides the information about the total quantity of dietary fats combined, consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for dietary fat. Curation status: Incomplete 160.0 210.0 ONSTR:ONSTR_8960610 Definition source: ONSTR curators. NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. non-critical positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency for infants with body mass at birth greater than 2500 grams non-critical NDBS screen for PAH deficiency non-critical PAH deficiency screen non-critical newborn screen for PAH deficiency non-critical newborn screen for PKU non-critical newborn screen for phenylketonuria Non-critical positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency for infants with body mass at birth greater than 2500 grams is a positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency for infants with body mass at birth greater than 2500 grams that is based on abnormally high whole blood phenylalanine concentration (in the range 160-210 μM) and abnormally high ratio between phenylalanine and tyrosine concentration (greater than 1.4), while the concentrations of other relevant amino acids, carnitine, and carnitine ester, and relevant concentration ratios fall within the laboratory established normal range. This type of positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency does not require immediate medical attention and/or intervention and treatment initiation. Curation status: Incomplete ONSTR:ONSTR_8963002 Definition source: ONSTR curators. blood plasma proline concentration measurement datum plasma Pro plasma Pro level plasma Pro status plasma proline concentration plasma proline measurement plasma proline status Blood plasma proline concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid proline in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_8963102 Definition source: ONSTR curators. blood citruline-to-arginine concentration ratio Cit-to-Arg Cit/Arg blood Cit-to-Arg ratio blood Cit/Arg Blood citruline-to-arginine concentration ratio is a blood amino-acid concentration ratio datum that provides the information about the how many times the concentration of citruline in the blood is greater than that of arginine. Curation status: Incomplete ONSTR:ONSTR_8965164 Definition source: ONSTR curators. estimated average nutrient requirement for female population age 31-to-50 years Estimated average nutrient requirement for female population age 31-to-50 years is an estimated average nutrient requirement for non-pregnant non-lactating female population that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of female population of 31 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_8968249 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.362-370. normal average daily dietary phosphorus intake normal mean phosphorus intake normal phosphorus intake Normal average daily dietary phosphorus intake is an average daily dietary phosphorus intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary phosphorus for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_8983485 Definition source: ONSTR curators percent upper tolerable vanadium intake level datum Percent upper tolerable vanadium intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of vanadium consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for vanadium. Curation status: Incomplete ONSTR:ONSTR_8984489 Definition source: ONSTR curators. estimated average nutrient requirement for infant population Estimated average nutrient requirement for infant population is an estimated average nutrient requirement for population age 0-to-8 years that denotes the quantity of a dietary nutrient estimated to satisfy the nutrient requirements of 50% of all members of infant population 0 to 12 months of age. Curation status: Incomplete ONSTR:ONSTR_8986811 Definition source: ONSTR curators percent adequate nutrient intake datum %AI percent AI percent DRI-AI Percent adequate nutrient intake datum is a percent dietary reference intake that provides the information about the quantity of specific dietary nutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake (AI) for the observed nutrient. Curation status: Incomplete ONSTR:ONSTR_8993767 Definition source: http://www.cdc.gov/growthcharts/charts.htm boys 2-to-5 years weight-for-stature percentile chart Weight-for-stature percentiles: Boys, 2 to 5 years boys weight-for-stature percentile chart boys weight-for-stature percentiles Boys 2-to-5 years weight-for-stature percentile chart is a 2-to-5 years weight-for-stature percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of weight measurement data (body mass measurements) with respect to height measurement data (body height measurements) in a population of healthy boys 2 to 5 years of age. Curation status: Incomplete ONSTR:ONSTR_8997308 Definition source: ONSTR curators. average daily dietary vitamin A intake per body mass during observed time interval Average daily dietary vitamin A intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of vitamin A contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_9013283 Definition source: ONSTR curators percent estimated average vitamin C requirement datum Percent estimated average vitamin C requirement is a percent estimated average vitamin requirement that provides the information about the quantity of vitamin C consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for vitamin C. Curation status: Incomplete ONSTR:ONSTR_9022128 Definition source: http://en.wikipedia.org/wiki/Medical_genetics molecular geneticist role Molecular geneticist role is a geneticist role that is realized during processes involving the discovery of and laboratory testing for DNA mutations that underline many single gene disorders. Curation status: Incomplete. 7.0 12.0 1.0 1.2 7.0 1.52 2.2 1.0 4.0 0.87 1.05 4.0 14.0 0.76 0.95 19.0 0.66 0.8 0.73 0.85 0.71 0.85 14.0 19.0 0.88 1.1 1.05 1.3 15.0 ONSTR:ONSTR_9030666 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.144-155. normal average daily total dietary protein intake per body mass Normal average daily total dietary protein per body mass is an average daily total protein intake per body mass during observed time interval that has value that has value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) for total dietary protein per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9038599 Definition source: ONSTR curators. average daily dietary energy intake per body mass during observed time interval datum Average daily dietary energy intake per body mass during observed time interval datum is a dietary energy intake datum providing information about the average dietary energy derived from all nutritional items combined that have been taken by a patient during observed time period (one day, two days or three days) with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_9046621 Definition source: ONSTR curators. average daily total dietary protein intake during observed time interval mean protein intake Average daily total dietary protein intake over observed time interval datum is an average daily dietary macronutrient intake during observed time interval denoting the average intake of total dietary proteins contained in all nutritional items that have been ingested by a human patient during the time interval observed by a dietitian (one day, two days or three days). Curation status: Incomplete 7.0 12.0 58.0 84.0 7.0 125.0 135.0 1.0 4.0 41.0 54.0 19.0 27.0 33.0 14.0 19.0 9.0 14.0 31.0 38.0 4.0 9.0 9.0 14.0 33.0 41.0 14.0 19.0 28.0 35.0 36.0 44.0 41.0 51.0 15.0 ONSTR:ONSTR_9047664 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. normal average daily dietary intake per body mass of phenylalanine and tyrosine combined Normal average daily dietary intake per body mass of phenylalanine and tyrosine combined is an average daily dietary intake per body mass of phenylalanine and tyrosine combined that has the value that falls within the range of values where minimal range value is equal to that of the estimated average requirement (DRI-EAR) and the maximal range value is equal to that of the recommended dietary allowance (DRI-RDA) for dietary phenylalanine and tyrosine combined per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9072455 Definition source: ONSTR curators. Definition source: Scheuermann, R.H., Ceusters, W., Smith, B. (2009) Toward an Ontological Treatment of Disease and Diagnosis. Proceedings of the 2009 AMIA Summit on Translational Bioinformatics, San Francisco, CA, p.116-120. disordered hepatocyte Disordered hepatocyte is a hapatocyte that is physically abnormal and whose physical abnormality may contribute to the emergence of a disease. Curation status: Incomplete A hepatocyte lacking certain enzyme due to gene deletion for that particular enzyme. Such hepatocyte is a type of disordered hepatocyte, because the absence of the enzyme in the cell. ONSTR:ONSTR_9072789 Definition source: ONSTR curators. percent recommended dietary chloride allowance Percent recommended dietary chloride allowance is a percent recommended dietary mineral allowance that provides the information about the quantity of dietary chloride consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for chloride. Curation status: Incomplete ONSTR:ONSTR_9086760 Definition source: ONSTR curators. recommended dietary allowance for female population age 14-to-18 years Recommended dietary allowance for female population age 14-to-18 years is a recommended dietary allowance for non-pregnant non-lactating female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy female population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_9099585 Definition source: ONSTR curators. average daily dietary histidine intake during observed time interval average daily dietary His intake daily His intake mean histidine intake Average daily histidine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid histidine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_9102193 Definition source: ONSTR curators. whole blood octanoylcarnitine concentration measurement datum blood C8 concentration blood octanoylcarnitine concentration whole blood C8 concentration whole blood octanoylcarnitine concentration Whole blood octanoylcarnitine concentration measurement datum is a whole blood carnitine ester concentration measurement datum that provides the information about the quantity of octanoylcarnitine in the human blood eluate or whole blood specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_9103661 Chemical composition or structure of a chemical entity that bears enzyme sustrate role is being altered in such way during the biochemical reaction catalyzed by the enzyme that the chemical entity as such ceases to exist. The chemical entity released from the enzyme active site (or regulatory domain) at the end of the biochemical reaction bears an enzyme product role. Definition source: http://en.wikipedia.org/wiki/Enzyme_substrate_(biology) enzyme product role Enzyme product role is a role of a chemical entity in a biochemical reaction that is born by a chemical entity (usually a molecule) that is during the biochemical reaction released from the enzyme active site or enzyme regulatory domain and that begins to exist during the the biochemical reaction catalyzed by the enzyme. Curation status: Incomplete ONSTR:ONSTR_9111606 Definition source: ONSTR curators. average daily dietary vanadium intake per body mass during observed time interval Average daily dietary vanadium intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary vanadium contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete 7.0 12.0 32.0 7.0 36.0 1.0 4.0 21.0 4.0 9.0 16.0 14.0 19.0 9.0 14.0 15.0 14.0 19.0 19.0 14.0 9.0 14.0 17.0 18.0 19.0 15.0 ONSTR:ONSTR_9127000 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-465. Note: The DRIs provided for the amino-acid intakes differ with repect to the observed age group. For the infant population age 0 to 6 months provided DRI is the adequate intake per body mass (DRI-AI), expresed in mg/kg/d. For populations older than 7 months of age, provided DRIs are the estimated average requirement (DRI-EAR) and the recommended dietary allowance (DRI-RDA), expressed in mg/kg/d. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466.] high average daily dietary histidine intake per body mass High average daily dietary histidine per body mass is an average daily histidine intake per body mass during observed that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary histidine per body mass for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9145873 Definition source: ONSTR curators. average daily dietary iodine intake per body mass during observed time interval Average daily dietary iodine intake per body mass during observed time interval is an average daily dietary mineral intake per body mass during observed time interval denoting the average quantity of dietary iodine contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_9153395 Definition source: ONSTR curators. adequate nutrient intake for infant population age 7-to-12 months Adequate nutrient intake for infant population age 7-to-12 months is an adequate nutrient intake for infant population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy infant population 7 to 12 months of age. Curation status: Incomplete ONSTR:ONSTR_9158460 Definition source: ONSTR curators. recommended dietary allowance for male population age 70 years and older Recommended dietary allowance for male population age 70 years and older is a recommended dietary allowance for male population denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy male population age 70 years and older. Curation status: Incomplete ONSTR:ONSTR_9167921 Definition source: ONSTR curators. average daily dietary energy intake datum Average daily dietary energy intake datum is a dietary energy intake datum that provides the information about the average quantity of dietary energy derived from all nutritional items taken by a human patient or study subject during the time interval relevant for dietary analysis and that is the output of the nutrient intake analysis. Curation status: Incomplete ONSTR:ONSTR_9168636 Definition source: ONSTR curators. average daily dietary cysteine intake during observed time interval average daily dietary Cys intake daily Cys intake Average daily cysteine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid cysteine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_9179705 Definition source: The US Secretary of Health and Human Services' Advisory Committee on Heritable Disorders and genetic Diseases in Newborns and Children.(2011) Newborn Screening: Toward A Uniform Screening Panel and System. Retrieved on 01/07/2013, from http://www.hrsa.gov/advisorycommittees/mchbadvisory/heritabledisorders/uniformscreening.pdf newborn screening short-term follow-up process objective Newborn screening short-term follow-up process objective is an objective specification of an objective to complete screening process of all infants (repeated screening, as well as second and third tier testing), report abnormal screen results appropriately and expediently to all interested parties (family or child caregiver, primary care physician etc.), timely identify and locate affected infants and their care givers and health care providers, provide appropriate referral and promptly initiate the treatment where needed and applicable. Curation status: Incomplete ONSTR:ONSTR_9195256 Definition source: http://en.wikipedia.org/wiki/Dried_blood_spot Dried blood spot specimens are stored in low gas-permeability plastic bags with desiccant added to reduce humidity and may be kept at ambient temperature. Due to its clinical effectiveness and cost effective collection and easy transportation and storage dried blood spot specimens have gained wide application in not only in newborn screening programs, but also in clinical trials, blood glucose level monitoring in diabetic patients etc. dried blood spot specimen creation DBS sampling Dried blood spot specimen creation is a blood specimen collecting performed by blotting drops of blood (usually five drops of blood) drawn from heel, toe, finger or vein onto designated areas on the specially manufactured and labeled absorbent filter paper (also known and Guthrie card) after which blotted blood is allowed to thoroughly saturate the filter paper and is air dried for several hours. Curation status: Incomplete ONSTR:ONSTR_9198598 Definition source: ONSTR curators. recommended dietary allowance for pregnant female population Recommended dietary allowance for pregnant female population is a recommended dietary allowance for female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy pregnant female population 14 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_9198656 Definition source: ONSTR curators percent upper tolerable nutrient intake level datum percent DRI-UL percent UL Percent upper tolerable nutrient intake level datum is a percent dietary reference intake that provides the information about the quantity of specific dietary nutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed nutrient. Curation status: Incomplete ONSTR:ONSTR_9206560 Definition source: ONSTR curators percent upper tolerable fluoride intake level datum Percent upper tolerable fluoride intake level is a percent upper tolerable mineral intake level that provides the information about the quantity of fluoride consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for fluoride. Curation status: Incomplete ONSTR:ONSTR_9210763 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC., pp.218-223. high average daily dietary choline intake high choline intake high mean choline intake High average daily dietary choline intake is an average daily dietary choline intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary choline for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9220172 Definition source: Academy of Nutrition and Dietetics (2013) International Dietetics and Nutrition Terminology (IDNT) Reference Manual. Standardized Language for the Nutrition Care Process. 4th Ed. Academy of Nutrition and Dietetics, Chicago, IL, pp. 67-76. nutrition monitoring Nutrition monitoring is a health care process that realizes the dietitian role and that is a preplanned review of changes observed in various measurements over time (nutritional intakes, blood metabolites, physical and physcho-cognitive growth and development) with the goal to determine and improve the effectiveness of the nutrition treatment. Curation status: Incomplete ONSTR:ONSTR_9225050 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.122-139. normal average daily dietary linoleic acid intake normal daily linoleic acid intake normal linoleic acid intake normal mean linoleic acid intake Normal average daily dietary linoleic acid intake is an average daily dietary linoleic acid intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary linoleic acid (LA) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9235387 Definition source: ONSTR curators nutritional formula datum Nutritional formula datum is a nutritional item datum that provides the information about the kinds and quantities of nutritional formula prescribed to or consumed by a human patient. Curation status: Incomplete ONSTR:ONSTR_9239980 Definition source: ONSTR curators. average daily dietary vitamin intake during observed time interval Average daily dietary vitamin intake during observed time interval is an average daily dietary micronutrient intake during observed time interval denoting the average quantity of relevant dietary vitamins contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_9243312 Blood 25(OH)D level is the best indicator of vitamin D status. It has fairly long half-life (15 days) and serves as a biomarker of Sun exposure (precisely, the exposure to the ultra-violet rays from the sunlight). Serum 25(OH)D level does not indicate the amount of vitamin D stored in body tissues. [Source: http://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ ] Definition source: http://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ Many lab websites have the information that the 25-hydroxy vitamin D test provides the information about the about the sum of quantity of 25-hydroxy vitamin D3 and 25-hydroxy vitamin D2. Formula 25(OH)D, however, generally refers to 25-hydroxycholecalciferol which is 25-hydroxy form of vitamin D3 (cholecalciferol) but not 25-hydroxy form of vitamin D2 (ergocalciferol). Vitamin D3 is a seco-steroid while vitamin D2 is a seco-ergostan (according to ChEBI), two structurally different chemical entities. blood 25-hydroxyvitamin D concentration measurement datum blood 25(OH)D level blood 25-hydroxyvitamin D level blood calcidiol level circulating 25(OH)D circulating 25-OH vitamin D serum 25(OH)D level Blood 25-hydroxyvitamin D concentration measurement datum is a blood vitamin D concentration measurement datum that provides the information about the sum quantity of 25-hydroxycholecalciferol (also known as calcidiol or 25-hydroxyvitamin D3 or 25(OH)D, the physiologically inactive form of vitamin D) and 25-hydroxyergocalciferol (also known as 25-hydroxy vitamin D2) in the blood which reflects the quantity of vitamin D produced cutaneously and obtained from consumed food and dietary supplements. Curation status: Incomplete Need to doublec heck vitamon D2 forms. 0.025 ONSTR:ONSTR_9252254 NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. positive newborn dried blood spot screening finding for medium-chain acyl-coenzyme A dehydrogenase deficiency for infants with body mass at birth greater than 2500 grams positive NDBS for MCADD positive NDBS for medium-chain acyl-coenzyme A dehydrogenase deficiency positive newborn screen for MCADD positive screen for MCADD presumptive positive newborn screen for MCADD presumptive positive screen for MCADD Positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency is a newborn dried blood spot screening finding that is based on abnormally high whole blood octanoylcarnitine concentration (greater than 0.35 μM) and abnormally high ratio between acetylcarnitine and octanoylcarnitine concentration (greater than 0.025), while the concentrations of relevant blood amino acids, carnitine, and other carnitine esters, and relevant concentration ratios fall within the laboratory established normal ranges. Curation status: Incomplete 1.4 ONSTR:ONSTR_9253243 Definition source: ONSTR curators. NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency for infants with body mass at birth greater than 2500 grams positive NDBS for PAH deficiency positive NDBS for phenylalanine hydroxylase deficiency positive newborn screen for PAH deficiency positive screen for PAH deficiency presumptive positive newborn screen for PAH deficiency presumptive positive screen for PAH deficiency Positive newborn dried blood spot screening finding for phenylalanine hydroxylase deficiency is a newborn dried blood spot screening finding that is based on abnormally high whole blood phenylalanine concentration (greater than 160 uM) and abnormally high ratio between phenylalanine and tyrosine concentration (greater than 1.4), while the concentrations of other relevant amino acids, carnitine, and carnitine ester, and relevant concentration ratios fall within the laboratory established normal ranges. Curation status: Incomplete ONSTR:ONSTR_9261993 Definition source: ONSTR curators. average daily dietary methionine intake during observed time interval average daily dietary Met intake daily Met intake Average daily methionine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid methionine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_9267776 Definition source: ONSTR curators. screened disease ACMG code Screened disease ACMG code is a symbol representing the diagnosis of one of the diseases that are being screened for during the newborn screening processes and that is created by the American College of Medical Genetics and Genomics (ACMG). Curation status: Incomplete ONSTR:ONSTR_9281026 Definition source: ONSTR curators percent adequate valine intake datum Percent adequate valine intake is a percent adequate amino-acid intake that provides the information about the quantity of amino-acid valine consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for valine. Curation status: Incomplete ONSTR:ONSTR_9281144 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp. 296-303. normal average daily dietary chromium intake normal chromium intake normal mean chromium intake Normal average daily dietary chromium intake is an average daily dietary chromium intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) for dietary chromium for for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9281587 Definition source: ONSTR curators. percent recommended dietary nutrient allowance datum %RDA percent DRI-RDA percent RDA percent recommended daily allowance Percent recommended dietary nutrient allowance datum is a dietary nutrient intake datum which provides the information about the quantity of a dietary nutrient consumed by a human during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary nutrient allowance (RDA) for that specific nutrient. Curation status: Incomplete ONSTR:ONSTR_9284746 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.459-466. Note: In the case of daily dietary amino-acid intakes, the only reference value (one out of four DRIs) provided is the adequate intake (DRI-AI) for infant population 0 to 6 months of age, expressed in mg/d. All other daily amino-acid intakes are provided in the form of average daily intakes per body mass (expressed in mg/kg/d). [Source:[Source:[Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC, pp.459-466. high average daily dietary isoleucine intake high isoleucine intake high mean isoleucine intake High average daily dietary isoleucine intake is an average daily dietary histidine intake during observed time interval that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for dietary isoleucine for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9287404 Definition source: Scriver, C. R., Sly, W. S., Childs, B., Baudet, A. L., Valle, D., Kinzler, K. W., Vogelstein, B. (2000) The metabolic and molecular bases of inherited metabolic disease, 8th Ed. McGraw-Hill Professional. Need better NL def and def source. mild phenylketonuria mild PKU Mild phenylketonuria is a hyperphenylalaninemina characterized by blood phenyalalnine concentration in the range 600-900 μmol/L (10-15 mg/dL). Curation status: Incomplete ONSTR:ONSTR_9332854 Definition source: ONSTR curators. percent recommended dietary riboflavin allowance Percent recommended dietary riboflavin allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary riboflavin consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for riboflavin. Curation status: Incomplete ONSTR:ONSTR_9345452 Definition source: ONSTR curators. percent recommended dietary glycine allowance Percent recommended dietary glycine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary glycine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid glycine. Curation status: Incomplete ONSTR:ONSTR_9355344 Definition source: ONSTR curators percent estimated average aspartic acid requirement datum Percent estimated average aspartic acid requirement is a percent estimated average amino-acid requirement that provides the information about the quantity of aspartic acid consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for aspartic acid. Curation status: Incomplete ONSTR:ONSTR_9357010 Definition source: ONSTR curators percent estimated average manganese requirement datum Percent estimated average manganese requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of manganese consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for manganese. Curation status: Incomplete ONSTR:ONSTR_9358954 Definition source: ONSTR curators. abnormally low enzyme catalytic activity rate profile Abnormally low enzyme catalytic activity rate process profile is an enzyme catalytic activity rate process profile that the measurement values thereof fall below normal (average) range for the activity rate of that particular enzyme measured under normal physiological conditions (normal cytosolic pH, temperature and substrate saturation). Curation status: Incomplete ONSTR:ONSTR_9367124 Definition source: ONSTR curators. percent recommended dietary amino-acid allowance Percent recommended dietary amino-acid allowance is a percent recommended dietary macronutrient allowance that provides the information about the quantity of specific dietary amino-acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for observed amino-acid. Curation status: Incomplete ONSTR:ONSTR_9407520 Definition source: ONSTR curators. unit vitamin per unit mass per unit time Unit vitamin per unit mass per unit time is a dietary nutrient intake per unit time that is a measure of the number of vitamin specific units taken by a human in a given time interval with respect to human body mass. Curation status: Incomplete ONSTR:ONSTR_9411314 Definition source: ONSTR curators. Definition source: http://purl.bioontology.org/ontology/CSP/0467-2059 body mass constituent composition Body mass constituent composition is human body quality that inheres in human body by virtue of the relative quantities or relative ratios of substances constituting human body. Curation status: Incomplete Body fat composition inheres in human body by virtue of the amount of fat contained in human body. In other words, body fat composition is a quality that inheres in human body (which is the bearer of this quality). ONSTR:ONSTR_9415312 Definition source: Hovasi Cox, J., Melbardis, I. M. (2005) Parenteral nutrition. In Handbook of pediatric nutrition, 3rd Ed. Jones and Bartlett publishers Inc. pp. 525-557. Definition source: Mirtallo, J., Canada, T., Kumpf, V., Petersen, C., Sacks, G., Seres, D., Guenter, P. (2004) Safe practices for parenteral nutrition. Journal of parenteral and enteral nutrition, Vol. 28, No. 6, Suppl. Nov-Dec 2004. Parenteral three-in-one solutions are available as already prepared pharmaceutical products or can be made on site (mixed in a single bag). They are cost-effective and convenient, however, unlike the two-in-one solutions, they contain fat and are thus a sort of lipid emulsion which is more significantly influenced by pH and temperature. [Source: Hovasi Cox, J., Melbardis, I. M. (2005) Parenteral nutrition. In Handbook of pediatric nutrition, 3rd Ed. Jones and Bartlett publishers Inc. pp. 525-557. ] parenteral three-in-one solution TNA parenteral three-in-one admixture solution three-in-one admixture three-in-one solution total nutrient admixture Parenteral three-in-one solution is a parenteral nutrition solution that is a mixture of parenteral dextrose solution, parenteral amino-acid solution and parenteral lipid solution and may also contain mineral nutrients, trace elements and vitamins. Curation status: Incomplete ONSTR:ONSTR_9415873 Definition source: Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.14. In defective phenylalanine hyrdoxylase dimer complex at least one of the monomers is a dysfunctional phenyalalnine-4-hydroxylase monomer, while in defective phenylalanine hyrdoxylase tetramer complex one or more monomers may be defective phenyalalnine-4-hydroxylase monomer. defective phenylalanine-4-hyrdoxylase complex defective PAH defective PAH complex defective phenylalanine hyrdoxylase complex dysfunctional PAH dysfunctional PAH complex dysfunctional phenylalanine-4-hyrdoxylase complex A phenyalalnine-4-hydroxylase complex (phenyalalnine-4-hydroxylase dimer or tetramer) having at least one monomer (sub-unit) that is a disfunctional phenyalalnine-4-hydroxylase monomer, and as such cannot act as a fully functional catalyzer of conversion of phenylalanine into tyrosine (i.e. has decreased PAH catalytic activity rate). Curation status: Incomplete ONSTR:ONSTR_9432852 Definition source: ONSTR curators. arterial blood specimen Arterial blood specimen is a blood specimen that is derived from portion of human arterial blood and is specified output of arterial blood specimen collecting. Curation status: Incomplete ONSTR:ONSTR_9436244 Definition source: Hinman,A.R., Mann,Y.M., Singh,H.R. (2009) Newborn dried bloodspot screening: mapping the clinical and public health components and activities. Genetics in Medicine, Vol.11, No. 6, June 2009. In the U.S. the process of newborn screening across states and NBS programs is not yet fully harmonized and standardized and the set and the sequence of NBS sub-processes may vary considerably. newborn screening proper process NBS NBS proper process newborn screening Newborn screening proper process is a newborn screening follow-up system process that is the aggregate of health care processes generally unfolding immediately or shortly after birth (initial screening) or within first week or two weeks of infant' life (repeated screening). Curation status: Incomplete ONSTR:ONSTR_9443463 Definition source: ONSTR curators percent estimated average cholesterol requirement datum Percent estimated average cholesterol requirement is a percent estimated average macronutrient requirement that provides the information about the quantity of cholesterol consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for cholesterol intake. Curation status: Incomplete ONSTR:ONSTR_9461265 Definition source: ONSTR curators percent adequate sulfate intake datum Percent adequate sulfate intake is a percent adequate dietary mineral intake that provides the information about the quantity sulfate consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for sulfate. Curation status: Incomplete ONSTR:ONSTR_9462546 Definition source: ONSTR curators. average daily dietary tyrosine intake during observed time interval average daily dietary Tyr intake daily Tyr intake Average daily dietary tyrosine intake during observed time interval is an average daily dietary amino-acid intake during observed time interval denoting the average quantity of amino-acid tyrosine contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_9471223 Definition source: ONSTR curators. average daily dietary biotin intake during observed time interval daily dietary vitamin H intake daily vitamin H intake mean biotin intake Average daily dietary biotin intake during observed time interval is an average daily dietary vitamin intake during observed time interval denoting the average quantity of biotin contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_9476641 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. normal average daily dietary intake of methionine and cysteine combined Normal average daily dietary intake of methionine and cysteine combined is an average daily dietary intake during observed time interval of methionine and cysteine combined that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary methionine and cysteine combined for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9477126 Definition source: ONSTR curators. percent recommended dietary glutamic acid allowance Percent recommended dietary glutamic acid allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary glutamic acid consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for glutamic acid. Curation status: Incomplete ONSTR:ONSTR_9511961 Definition source: ONSTR curators. adequate nutrient intake for children population age 1-to-3 years Adequate nutrient intake for children population age 1-to-3 years is an adequate nutrient intake for children population that denotes the average daily intake of a nutrient based on observed or experimentally determined approximations or estimates of the nutrient intake that is assumed to be adequate for healthy children 1 to 3 years of age. Curation status: Incomplete ONSTR:ONSTR_9520679 Definition source: Asfaw, M., Buchanan, C., Davis, R., Glassman, M., Noakes, W., O'Leary, E.,Wasseff, S. (1993) Pediatric parenteral nutrition support handobook. Nutrition support service, Egleston Children's Hospital, Emory University, Atlanta, GA, pp. 6-10. Electrolytes provided in parenteral solution must maintain neutral polarity, i.e. the number of cations (positively charged particles) must be matched with the number of anions (negatively charged). [Source: http://www2.kumc.edu/pharmacy/Nutrition_Info_Handbook/VI._Parenteral_Nutrition_(PN).pdf ] parenteral electrolyte solution intravenous electrolyte solution Parenteral electrolyte solution is a parenteral nutrition solution composed of sterile water and one or more essential mineral nutrients (sodium, potassium, calcium, magnesium, phosphorus). Curation status: Incomplete ONSTR:ONSTR_9522419 Definition source: ONSTR curators. average daily dietary magnesium intake during observed time interval average dietary Mg intake daily dietary magnesium intake daily magnesium intake mean magnesium intake Average daily dietary magnesium intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of dietary magnesium contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_9525536 Definition source: http://www.cdc.gov/growthcharts/charts.htm boys birth-to-36 months weight-for-length percentile chart Weight-for-length percentiles: Boys, birth to 36 months boys weight-for-length percentile chart boys weight-for-length percentiles Boys birth-to-36 months weight-for-length percentile chart is a birth-to-36 months weight-for-height percentile chart consisting of smoothed percentile curves illustrating the distribution(s) of weight measurement data (body mass measurements) with respect to height measurement data (body height measurements) in a population of healthy boys 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_9527458 Definition source: ONSTR curators. blood plasma leucine concentration measurement datum plasma Leu plasma Leu level plasma leucine concentration plasma leucine measurement plasma leucine status Blood plasma leucine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid leucine in human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_9531195 Definition source: ONSTR curators percent estimated average calcium requirement datum Percent estimated average calcium requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of calcium consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for calcium. Curation status: Incomplete ONSTR:ONSTR_9545140 Definition source: ONSTR curators consumed nutritional item datum Consumed nutritional item datum is a data item providing the information about the kinds and quantities of nutritional items consumed by a human patient during the time interval relevant for dietary analysis. Curation status: Incomplete ONSTR:ONSTR_9552783 Definition source: ONSTR curators. average daily dietary vitamin B12 intake per body mass during observed time interval Average daily dietary vitamin B12 intake per body mass during observed time interval is an average daily dietary vitamin intake per body mass during observed time interval information denoting the average quantity of vitamin B12 contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_9553648 Definition source: ONSTR curators. recommended dietary allowance for lactating female population age 14-to-18 years Recommended dietary allowance for lactating female population age 14-to-18 years is a recommended dietary allowance for lactating female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of lactating healthy female population 14 to 18 years of age. Curation status: Incomplete ONSTR:ONSTR_9560311 Definition source: ONSTR curators. nutritional item role Nutritional item role is a material to be added role born by a nutritional item and that is realized by the process of enteral or parenteral administration where the the target of material addition role is born by a Homo sapiens. Curation status: Incomplete. ONSTR:ONSTR_9579536 Definition source: ONSTR curators. percent recommended dietary proline allowance Percent recommended dietary proline allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary proline consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid proline. Curation status: Incomplete ONSTR:ONSTR_9603112 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.274-279. normal average daily dietary riboflavin intake normal mean riboflavine intake normal riboflavine intake Normal average daily dietary riboflavin intake is an average daily dietary riboflavin intake during observed time interval that has value that is equal to that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) or the estimated average requirement (DRI-EAR) for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9619776 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 459-465. high average daily dietary intake of phenylalanine and tyrosine combined High average daily dietary intake of phenylalanine and tyrosine combined is an average daily dietary intake during observed time interval of phenylalanine and tyrosine combined that has value that is greater than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary methionine and cysteine combined for the population corresponding to patient's sex, age and state (lactating or non-lactating, if female older than 15 years of age). Curation status: Incomplete 7.0 12.0 11.0 7.0 13.0 1.0 4.0 13.0 4.0 9.0 19.0 9.0 14.0 34.0 52.0 46.0 14.0 19.0 56.0 46.0 19.0 15.0 71.0 ONSTR:ONSTR_9624808 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National Academies Press, Washington DC., pp. 144-155. high average daily total dietary protein intake high daily protein intake high mean protein intake high protein intake High average daily dietary protein intake is an average daily total dietary protein intake during observed time interval that has value that is greater than that of the recommended dietary allowance (DRI-RDA) or the adequate intake (DRI-AI) or for total dietary protein for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9632213 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.196-201. high average daily dietary biotin intake high biotin intake high mean biotin intake High average daily dietary biotin intake is an average daily dietary biotin intake during observed time interval that has value that is greater than that of the adequate intake (DRI-AI) for dietary biotin for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9633642 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 birth-to-36-months weight-for-age percentile chart infant weight-for-age percentile chart Birth-to-36-months weight-for-age percentile chart is a weight-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of weight measurement data (body mass measurements) with respect to age in a population of healthy infants 0 to 36 months of age. Curation status: Incomplete ONSTR:ONSTR_9639186 Definition source: http://www.cdc.gov/ncbddd/heartdefects/screening.html Definition source: http://www.cdc.gov/ncbddd/pediatricgenetics/documents/CCHD-factsheet.pdf newborn screening for critical congenital heart diseases Newborn screening for critical congenital heart diseases is a point-of-care newborn screening proper process that includes pulse oximetry test and that is usually done within first 48 hours post birth (or latest before a newborn has been discharged from a hospital, with the goal to detect the presence of some of congenital heart defects that if left untreated can cause disability or death. Curation status: Incomplete ONSTR:ONSTR_9660945 Definition source: ONSTR curators percent estimated average folacin requirement datum Percent estimated average folacin requirement is a percent estimated average vitamin requirement that provides the information about the quantity of folacin consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for folacin. Curation status: Incomplete ONSTR:ONSTR_9660977 Definition source: ONSTR curators. percent recommended dietary glutamine allowance Percent recommended dietary glutamine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary glutamine consumed by a human patient during the time interval relevant for dietary intake analysis, that is expressed as percentage of the recommended dietary allowance for amino-acid glutamine. Curation status: Incomplete ONSTR:ONSTR_9669357 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp. 296-303. low average daily dietary chromium intake low chromium intake low mean chromium intake Low average daily dietary chromium intake is an average daily dietary chromium intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) for dietary chromium for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9677528 Definition source: ONSTR curators. percent recommended dietary leucine allowance Percent recommended dietary leucine allowance is a percent recommended dietary amino-acid allowance that provides the information about the quantity of dietary leucine consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for amino-acid leucine. Curation status: Incomplete ONSTR:ONSTR_9679076 Definition source: ONSTR curators. unit vitamin per unit time Unit vitamin per unit time is a nutrient intake per unit time that is a measure of the number of vitamin specific units taken by a human in a given time interval. Curation status: Incomplete ONSTR:ONSTR_9693057 Chemical composition or structure of a chemical entity that bears enzyme sustrate role is being altered in such way during the biochemical reaction catalyzed by the enzyme that the chemical entity as such ceases to exist. The chemical entity released from the enzyme active site at the end of the biochemical reaction bears an enzyme product role. Definition source: http://en.wikipedia.org/wiki/Enzyme_substrate_(biology) While some enzyme act upon only one substrate (single-substrate enzymes), e.g. hexokinase and some isomerases, majority of enzymes bind multiple substrates (molecules that enzymes have affinity for and cofactors which usually are not enzyme specific but whose chemical composition may be altered during the enzyme catalyzed reaction). [Source: http://en.wikipedia.org/wiki/Enzyme_kinetics ] enzyme substrate role Enzyme substrate role is a role of a chemical entity in a biochemical reaction that is born by a chemical entity (usually molecule) that is during a biochemical reaction bound to the enzyme active site or enzyme regulatory domain to form enzyme-substrate complex and whose chemical composition or structure is been altered during the reaction, and which as such ceases to exist during this reaction. Curation status: Incomplete ONSTR:ONSTR_9698884 Definition source: ONSTR curators. average daily total dietary fiber intake per body mass during observed time interval Average daily total dietary fiber intake per body mass during observed time interval is an average daily dietary macronutrient intake per body mass during observed time interval denoting the average intake of fibers contained in all nutritional items taken by a human patient during the observed time period with respect to patient's body mass. Curation status: Incomplete ONSTR:ONSTR_9730100 Definition source: ONSTR curators. weight-for-age percentile Body weight [Percentile] Per age Body weight growth percentile Body weight percentile Child weight centile body mass-for-age percentile body weight centile body weight-for-age percentile weight centile Weight-for-age percentile is a developmental growth indicator showing the percentage of children (in a reference population distribution) that are of the same age as the assessed child, and whose weight measurement datum has equal or smaller value than that of the child being assessed at the time of given physical examination. Curation status: Incomplete ONSTR:ONSTR_9742046 Definition source: ONSTR curators percent upper tolerable threonine intake level datum Percent upper tolerable threonine intake level is a percent upper tolerable amino-acid intake level that provides the information about the quantity of amino-acid threonine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for threonine. Curation status: Incomplete ONSTR:ONSTR_9748599 Definition source: ONSTR curators. recommended dietary allowance for lactating female population Recommended dietary allowance for lactating female population is a recommended dietary allowance for female population that denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of lactating healthy female population 14 to 50 years of age. Curation status: Incomplete ONSTR:ONSTR_9752476 Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) Dietary Reference Intakes: The essential guide to nutrient requirements. The National academies press, Washington DC, pp.402-413. low average daily dietary zinc intake low mean zinc intake low zinc intake Low average daily dietary zinc intake is an average daily dietary zinc intake during observed time interval that has value that is less than that of the adequate intake (DRI-AI) or the recommended dietary allowance (DRI-RDA) for dietary zinc for the population corresponding to patient's sex, age and state (lactating or pregnant, if female older than 15 years of age). Curation status: Incomplete ONSTR:ONSTR_9766040 Definition source: ONSTR curators. identifying patient with positive newborn dried blood spot screening test result identifying patient with positive newborn dried blood spot screen Identifying patient with positive dried blood spot screening test result is a planned process that consists of matching the newborn dried blood spot result to the patient record containing the name and contact information of affected patient. Curation status: Incomplete ONSTR:ONSTR_9784216 Definition source: ONSTR curators percent upper tolerable fat intake level datum Percent upper tolerable fat intake level is a percent upper tolerable macronutrient intake level that provides the information about the total quantity of all fats combined, consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for the observed for (total) fat. Curation status: Incomplete ONSTR:ONSTR_9799826 Definition source: ONSTR curators. body mass index calculation objective Body mass index calculation objective is data transformation objective where the goal of data transformation is to calculate the body mass index from the input data (human body mass measurement datum and body height measurement datum). Curation status: Incomplete ONSTR:ONSTR_9802605 Definition source: ONSTR curators percent upper tolerable biotine intake level datum Percent upper tolerable biotine intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of biotine consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for biotine. Curation status: Incomplete ONSTR:ONSTR_9803406 Definition source: ONSTR curators. blood plasma carnitine concentration measurement datum plasma C0 plasma C0 level plasma carnitine concentration plasma carnitine level Blood plasma carnitine concentration measurement datum is a blood carnitine measurement datum that provides the information about the quantity of carnitine in the blood plasma specimen collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_9828768 Definition source: ONSTR curators. upper tolerable nutrient intake level for female population age 19-to-30 years Upper tolerable nutrient intake level for female population age 19-to-30 years is an upper tolerable nutrient intake level for non-pregnant non-lactating female population that denotes the highest nutrient intake estimated to pose no risk of adverse health effects to almost all members of healthy female population 19 to 30 years of age. Curation status: Incomplete ONSTR:ONSTR_9828959 Definition source: ONSTR curators. average daily dietary intake per body mass of phenylalanine and tyrosine combined Average daily dietary intake per body mass of phenylalanine and tyrosine combined is an average daily dietary amino-acid intake per body mass during observed time interval denoting the average quantity of a amino-acids phenylalanine and tyrosine combined, contained in all food items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete 0.67 ONSTR:ONSTR_9829992 Definition source: ONSTR curators. NOTE: Due to the variations in laboratory methods and/or equipment, for all relevant amino acid concentrations, carnitine and carnitine esters concentrations and concentration ratios, normal ranges and/or abnormally high/low cutoff values, on the national level there are no established common normal/abnormal ranges and cutoff values. Normal/abnormal ranges and cutoff values used in the ONSTR are those established by and used in the State of Georgia. critical positive newborn dried blood spot screening finding for medium-chain acyl-coenzyme A dehydrogenase deficiency for infants with body mass at birth greater than 2500 grams critical MCADD screen critical NDBS screen for MCADD critical newborn screen for medium-chin co-enzyme A dehydrogenase deficiency critical screen for MCADD Critical positive dried blood spot screening finding for medium-chin co-enzyme A dehydrogenase deficiency is a positive newborn dried blood spot screening finding for medium-chain acyl-coenzyme A dehydrogenase deficiency that is based on abnormally high whole blood octanoylcarnitine concentration (greater than 0.67 μM) and abnormally high ratio between acetylcarnitine and octanoylcarnitine concentration (greater than 0.025), while the concentrations of relevant blood amino acids, carnitine, and other carnitine esters, and relevant concentration ratios fall within the laboratory established normal ranges. This type of positive newborn dried blood spot screening finding for medium-chin co-enzyme A dehydrogenase deficiency requires immediate medical attention and/or intervention and treatment initiation. Curation status: Incomplete ONSTR:ONSTR_9832619 Definition source: ONSTR curators. recommended dietary allowance for male population age 51-to-70 years Recommended dietary allowance for male population age 51-to-70 years is a recommended dietary allowance for male population denotes the dietary nutrient intake sufficient to meet nutrient requirements of 97-98% of healthy male population 51 to 70 years of age. Curation status: Incomplete ONSTR:ONSTR_9839990 Definition source: ONSTR curators percent estimated average sodium requirement datum Percent estimated average sodium requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of sodium consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for sodium. Curation status: Incomplete ONSTR:ONSTR_9857078 Definition source: ONSTR curators. food item amino-acid content datum Food item amino-acid content datum is a scalar measurement datum providing the information about the content of the observed amino-acid in each food item consumed by human patient during the time period relevant for dietary intake analysis. Curation status: Incomplete ONSTR:ONSTR_9879168 Definition source: ONSTR curators. average daily dietary arachidonic acid intake per body mass during observed time interval average daily ArA intake per body mass daily ArA intake per body mass Average daily dietary arachidonic acid intake per body mass during observed time interval is an average daily dietary fatty acid intake per body mass during observed time interval denoting the average quantity of dietary arachidonic acid (ArA) contained in all nutritional items taken by a human patient during the observed time period with respect to the body mass of the the human patient. Curation status: Incomplete ONSTR:ONSTR_9887977 Definition source: ONSTR curators percent adequate macronutrient intake datum Percent adequate macronutrient intake is a percent adequate nutrient intake datum that provides the information about the quantity of specific dietary macronutrient consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for the observed macronutrient. Curation status: Incomplete ONSTR:ONSTR_9890320 Definition source: ONSTR curators. percent recommended dietary vitamin C allowance Percent recommended dietary vitamin C allowance is a percent recommended dietary vitamin allowance that provides the information about the quantity of dietary vitamin C consumed by a human patient during the time interval relevant for dietary intake analysis (one, two or three days), and that is expressed as percentage of the recommended dietary allowance for vitamin C. Curation status: Incomplete ONSTR:ONSTR_9890923 Definition source: ONSTR curators. average daily dietary chloride intake during observed time interval daily dietary chloride intake mean chloride intake Average daily dietary chloride intake during observed time interval is an average daily dietary mineral intake during observed time interval denoting the average quantity of all chlorides combined and contained in all nutritional items taken by a human patient over the time interval observed by a dietitian (one day, two days and/or three days). Curation status: Incomplete ONSTR:ONSTR_9901690 Definition source: http://www.cdc.gov/growthcharts/charts.htm#Set1 2-to-20-years weight-for-age percentile chart children and adolescent weight-for-age percentile chart 2-to-20-years weight-for-age percentile chart is a weight-for-age percentile chart consisting of smoothed percentile curves illustrating the distribution of weight measurement data (body mass measurements) with respect to age in a population of healthy children and adolescents 2 to 20 years of age. Curation status: Incomplete ONSTR:ONSTR_9906490 Definition source: http://en.wikipedia.org/wiki/Ferritin Definition source: http://www.prospecbio.com/Ferritin_Human_10_177 The serum ferritin level (the amount of ferriting in the blood) is directly related to the amount of iron stored in the body. [source: http://www.prospecbio.com/Ferritin_Human_10_177] blood serum ferritin concentration measurement datum ferritin measurement serum ferritin level Blood serum ferritin concentration measurement datum is a concentration measurement datum that is the output of the blood serum ferritin test that measures the concentration of ferritin complex in human blood. Curation status: Incomplete ONSTR:ONSTR_9935556 Definition source: ONSTR curators percent upper tolerable folacin intake level datum Percent upper tolerable folacin intake level is a percent upper tolerable vitamin intake level that provides the information about the quantity of folacin consumed (or to be consumed) by a human, that is expressed as the percentage of the upper tolerable intake level for folacin. Curation status: Incomplete ONSTR:ONSTR_9937675 Definition source: ONSTR curators. blood plasma glutamine concentration measurement datum plasma Gln plasma Gln level plasma Gln status plasma glutamine concentration plasma glutamine measurement plasma glutamine status Blood plasma glutamine concentration measurement datum is a blood plasma amino-acid concentration measurement datum that provides the information about the quantity of amino-acid glutamine in the human blood plasma specimen obtained from the blood specimen that has been collected from a patient at least 2.5 to 3 hours post feed. Curation status: Incomplete ONSTR:ONSTR_9939637 Definition source: Blau, N., Burton, B. K., Thoeny, B., van Sprosen F., Waisbren, S. (2010) Phenylketonuria and BH4 deficiencies. UNI-MED Verlag AGm D-283232 Bremen, International Medical Publishers (London, Boston), pp.62-64. heterozygous mutant phenylalanine hydroxilase genotype compound heterozygous PAH genotype compound heterozygous phenylalanine hydroxilase genotype heterozygous mutant PAH genotype A mutant phenylalanine hydroxilase genotype that includes two different mutated PAH monomer alleles (one copy of mutated PAH monomer allele that is inherited from the mother and which is not the same of mutated PAH monomer allele that has been inherited from the father). Curation status: Incomplete ONSTR:ONSTR_9960504 Definition source: http://www.webmed.com/diet/folic-acid blood folate concentration measurement datum plasma folate concentration plasma folate level plasma folate status serum folate concentration serum folate level serum folate status Blood folate concentration measurement datum is a concentration measurement datum that is the output of the immunoassay measuring the quantity of folic acid (folate) in the human blood serum or plasma specimen. Curation status: Incomplete ONSTR:ONSTR_9965048 Definition source: ONSTR curators. urine creatinine concentration measurement datum creatinine, random urine urine creatinine level urine creatinine measurement Urine creatinine concentration measurement datum is a urine chemical concentration measurement datum that provides the information about the concentration of creatinine in human urine specimen collected by patient at random time of the day. Curation status: Incomplete ONSTR:ONSTR_9987053 Definition source: ONSTR curators percent estimated average chromium requirement datum Percent estimated average chromium requirement is a percent estimated average dietary mineral requirement that provides the information about the quantity of chromium consumed (or to be consumed) by a human, that is expressed as the percentage of the estimated average requirement for chromium. Curation status: Incomplete ONSTR:ONSTR_9994295 Definition source: ONSTR curators percent adequate vitamin D intake datum Percent adequate vitamin D intake is a percent adequate vitamin intake that provides the information about the quantity of vitamin D consumed (or to be consumed) by a human, that is expressed as the percentage of the adequate intake for vitamin D. Curation status: Incomplete ONSTR:ONSTR_9997011 Definition source: ONSTR curators. dinner evening meal supper Dinner is a meal usually eaten by a human during the evening or in the late after noon. Curation status: Incomplete BFO:0000001 entity Entity Julius Caesar Verdi’s Requiem the Second World War your body mass index BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) entity Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf per discussion with Barry Smith An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) BFO:0000002 continuant Continuant BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] continuant Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] BFO:0000003 occurrent Occurrent BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] occurrent Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. per discussion with Barry Smith Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] BFO:0000004 ic IndependentContinuant a chair a heart a leg a molecule a spatial region an atom an orchestra. an organism the bottom right portion of a human torso the interior of your mouth b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] independent continuant b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] BFO:0000006 s-region SpatialRegion BFO 2 Reference: Spatial regions do not participate in processes. Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional. A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001]) All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001]) (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] spatial region Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional. per discussion with Barry Smith A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001]) All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001]) (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] BFO:0000008 t-region TemporalRegion Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] temporal region Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional per discussion with Barry Smith A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] BFO:0000009 2d-s-region TwoDimensionalSpatialRegion an infinitely thin plane in space. the surface of a sphere-shaped part of space A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001]) (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] two-dimensional spatial region A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001]) (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] BFO:0000011 st-region SpatiotemporalRegion the spatiotemporal region occupied by a human life the spatiotemporal region occupied by a process of cellular meiosis. the spatiotemporal region occupied by the development of a cancer tumor A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001]) All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001]) Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001]) Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001]) Every spatiotemporal region occupies_spatiotemporal_region itself. Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002]) (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] spatiotemporal region A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001]) All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001]) Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001]) Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001]) Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002]) (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] BFO:0000015 process Process a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping the course of a disease the flight of a bird the life of an organism your process of aging. p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] process p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] BFO:0000016 disposition Disposition an atom of element X has the disposition to decay to an atom of element Y certain people have a predisposition to colon cancer children are innately disposed to categorize objects in certain ways. the cell wall is disposed to filter chemicals in endocytosis and exocytosis BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type. b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] disposition b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] BFO:0000017 realizable RealizableEntity the disposition of this piece of metal to conduct electricity. the disposition of your blood to coagulate the function of your reproductive organs the role of being a doctor the role of this boundary to delineate where Utah and Colorado meet To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] realizable entity To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] BFO:0000018 0d-s-region ZeroDimensionalSpatialRegion A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001]) (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001] zero-dimensional spatial region A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001]) (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001] BFO:0000019 quality Quality the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] quality a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] BFO:0000020 sdc SpecificallyDependentContinuant Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key of one-sided specifically dependent continuants: the mass of this tomato of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates. the disposition of this fish to decay the function of this heart: to pump blood the mutual dependence of proton donors and acceptors in chemical reactions [79 the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction the pink color of a medium rare piece of grilled filet mignon at its center the role of being a doctor the shape of this hole. the smell of this portion of mozzarella b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] specifically dependent continuant b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. per discussion with Barry Smith (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] BFO:0000023 role Role John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] role b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] BFO:0000024 fiat-object-part FiatObjectPart or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29 the FMA:regional parts of an intact human body. the Western hemisphere of the Earth the division of the brain into regions the division of the planet into hemispheres the dorsal and ventral surfaces of the body the upper and lower lobes of the left lung BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004]) (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004] fiat object part b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004]) (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004] BFO:0000026 1d-s-region OneDimensionalSpatialRegion an edge of a cube-shaped portion of space. A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001]) (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001] one-dimensional spatial region A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001]) (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001] BFO:0000027 object-aggregate ObjectAggregate a collection of cells in a blood biobank. a swarm of bees is an aggregate of members who are linked together through natural bonds a symphony orchestra an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team) defined by fiat: the aggregate of members of an organization defined through physical attachment: the aggregate of atoms in a lump of granite defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container defined via attributive delimitations such as: the patients in this hospital the aggregate of bearings in a constant velocity axle joint the aggregate of blood cells in your body the nitrogen atoms in the atmosphere the restaurants in Palo Alto your collection of Meissen ceramic plates. An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee). ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158. b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004]) (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] object aggregate An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158. b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004]) (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004] BFO:0000028 3d-s-region ThreeDimensionalSpatialRegion a cube-shaped region of space a sphere-shaped region of space, A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001]) (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] three-dimensional spatial region A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001]) (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] BFO:0000029 site Site Manhattan Canyon) a hole in the interior of a portion of cheese a rabbit hole an air traffic control region defined in the airspace above an airport the Grand Canyon the Piazza San Marco the cockpit of an aircraft the hold of a ship the interior of a kangaroo pouch the interior of the trunk of your car the interior of your bedroom the interior of your office the interior of your refrigerator the lumen of your gut your left nostril (a fiat part – the opening – of your left nasal cavity) b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] site b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] BFO:0000030 object Object atom cell cells and organisms engineered artifacts grain of sand molecule organelle organism planet solid portions of matter star BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting. BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below). BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47 BFO 2 Reference: an object is a maximal causally unified material entity BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74 b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001]) object b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001]) BFO:0000031 gdc GenericallyDependentContinuant The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. the pdf file on your laptop, the pdf file that is a copy thereof on my laptop the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] generically dependent continuant b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] BFO:0000034 function Function the function of a hammer to drive in nails the function of a heart pacemaker to regulate the beating of a heart through electricity the function of amylase in saliva to break down starch into sugar BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc. A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] function A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] BFO:0000035 p-boundary ProcessBoundary the boundary between the 2nd and 3rd year of your life. p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001]) Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002]) (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002] (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001] process boundary p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001]) Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002]) (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002] (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001] BFO:0000038 1d-t-region OneDimensionalTemporalRegion the temporal region during which a process occurs. BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks). A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001]) (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] one-dimensional temporal region A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001]) (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] BFO:0000040 material MaterialEntity a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic the undetached arm of a human being BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] material entity A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] BFO:0000140 cf-boundary ContinuantFiatBoundary b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) BFO 2 Reference: In BFO 1.1 the assumption was made that the external surface of a material entity such as a cell could be treated as if it were a boundary in the mathematical sense. The new document propounds the view that when we talk about external surfaces of material objects in this way then we are talking about something fiat. To be dealt with in a future version: fiat boundaries at different levels of granularity.More generally, the focus in discussion of boundaries in BFO 2.0 is now on fiat boundaries, which means: boundaries for which there is no assumption that they coincide with physical discontinuities. The ontology of boundaries becomes more closely allied with the ontology of regions. BFO 2 Reference: a continuant fiat boundary is a boundary of some material entity (for example: the plane separating the Northern and Southern hemispheres; the North Pole), or it is a boundary of some immaterial entity (for example of some portion of airspace). Three basic kinds of continuant fiat boundary can be distinguished (together with various combination kinds [29 Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions. Every continuant fiat boundary is located at some spatial region at every time at which it exists (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001] continuant fiat boundary b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions. (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001] BFO:0000141 immaterial ImmaterialEntity BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10 immaterial entity BFO:0000142 1d-cf-boundary OneDimensionalContinuantFiatBoundary The Equator all geopolitical boundaries all lines of latitude and longitude the line separating the outer surface of the mucosa of the lower lip from the outer surface of the skin of the chin. the median sulcus of your tongue a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001]) (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001] one-dimensional continuant fiat boundary a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001]) (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001] BFO:0000144 process-profile ProcessProfile On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance. The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on. b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002]) b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005]) (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] process profile b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002]) b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005]) (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] BFO:0000145 r-quality RelationalQuality John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. a marriage bond, an instance of requited love, an obligation between one person and another. b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] relational quality b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] BFO:0000146 2d-cf-boundary TwoDimensionalContinuantFiatBoundary a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001]) (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001] two-dimensional continuant fiat boundary a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001]) (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001] BFO:0000147 0d-cf-boundary ZeroDimensionalContinuantFiatBoundary the geographic North Pole the point of origin of some spatial coordinate system. the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona. a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001]) (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001] zero-dimensional continuant fiat boundary zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona. requested by Melanie Courtot a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001]) (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001] BFO:0000148 0d-t-region ZeroDimensionalTemporalRegion a temporal region that is occupied by a process boundary right now the moment at which a child is born the moment at which a finger is detached in an industrial accident the moment of death. temporal instant. A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] zero-dimensional temporal region A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] BFO:0000182 history History A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001]) history A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001]) CHEBI:10362 beta-cryptoxantin A carotenol that has formula C40H56O. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:11060 (S)-carnitine (+)-D-carnitine (+)-carnitine D-(+)carnitine D-carnitine IUPAC name: (3S)-3-Hydroxy-4-(trumethylammonio)butanoate A carnitine that has formula C7H15NO3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:12777 vitamin A Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15354 choline A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15356 cysteine A sulfur-containing amino acid that has formula C3H7NO2S. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15372 tetrahydrobiopterin 5,6,7,8-tetrahydrobiopterin BH4 tetrahydrobiopterin A biopterin that has formula C9H15N5O3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15377 water An inorganic hydroxy compound that has formula H2O. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15379 dioxygen An elemental molecule that has formula O2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15428 glycine The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15729 L-ornithine An optically active form ofornithine having L-configuration. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15843 arachidonic acid A C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15891 taurine An amino sulfonic acid that has formula C2H7NO3S. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15904 long-chain fatty acid A fatty acid with a long chain of C13 or more. The term includes very long chain fatty acids, which have a chain lenght greater than C18. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15940 nicotinic acid A pyridinemonocarboxylic acid that has formula C6H5NO2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15956 biotin An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:15986 polynucleotide Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16113 cholesterol A cholestanoid consisting of cholestane havong a double bond at that 5,6-position as well as a 3beta-hydroxy group. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16134 ammonia An azane that consists of a single nitrogen atom covalently bonded to three hydrogen atoms. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16347 (R)-carnitine (-)-L-carnitine (-)-carnitine IUPAC name: (3R)-3-Hydroxy-4-(trumethylammonio)butanoate L-(-)carnitine L-carnitine levocarnitine A carnitine that has formula C7H15NO3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16349 L-citrulline The L-enantiomer of citrulline. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16410 pyridoxamine A vitamin B6 that has fomula C8H12N2O2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16449 alanine An alpha-amino acid that has formula C3H7NO2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16467 L-arginine An L-alpha-amino acid that is the L-isomer of arginine. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16646 carbohydrate The generic term 'carbohydrate' includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16709 pyridoxine A vitamin B6 that has fomula C8H11NO3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16737 creatinine A lactam obtained by formal cyclocondensation of creatine Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16811 methionine proline A pyrrolidine that has formula C5H9NO2. Suphur containing amino acid that has formula C5H11NO2S. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16828 L-tryptophan The L-enantiomer of tryptophan Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16857 L-threonine The L-enantiomer of the naturally occuring amino acid threonine. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:16977 L-alanine The L-enantiomer of alanine. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17015 riboflavin D-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety. It is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables, but the richest natural source is yeast. The free form occurs only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17115 L-serine The L-enantiomer of serine. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17126 carnitine An amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). Lab abbreviation C0 [SN:2014-04-15] CHEBI:17154 nicotinamide A puridine alkaloid that has formula C6H6N2O. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17230 homocysteine A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17295 L-phenylalanine The L-enantiomer of phenylalanine. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17310 pyridoxal A vitamin B6 that has fomula C8H9NO3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17351 linoleic acid An octadecadienoic acid containing two E (cis) double bonds at positions 9 and 12. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17387 O-acylcarnitine Any carboxylic ester obtained by the O-acylation of carnitine. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17405 4-pyridoxic acid A vitamin B6 that has fomula C8H9NO3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17439 cyanocob(III)alamin Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17485 homocystine An organic disulfide obtained by oxidative dimerisation of homocysteine. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17579 beta-carotene A cyclic carotete that has formula C40H56. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17822 serine An alpha-amino acid that has a formula C3H7NO3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17823 calcitriol A hydroxycalciol that has formula C27H44O3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17895 L-tyrosine An optically active form of tyrosine having L-configuration. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:17933 calcidiol A hydroxycalciol that has formula C27H44O2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:18059 lipid 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:18102 L-octanoylcarnitine IUPAC name: (3R)-3-(Octanoyloxy)-4-(trumethylammonio)butanoate L-Octanoyl carnitine O-octanoyl-L-carnitine O-octanoyl-R-carnitine The L-enantiomer of an O-acylcarnitine compound having octanoyl as the acyl substituent. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). Lab abbreviation C8 [SN:2014-04-15] CHEBI:18186 tyrosine An amino acid in which the side chain is a para-hydroxyphenyl group. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:18211 citrulline The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the N(5)-position. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:18237 glutamic acid An alpha-amino acid that has formula C5H9NO4. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:18257 ornithine An alpha-amino acid that us pentanoic acid bearing two amino substituents at positions 2 and 5. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22470 alpha-tocopherol Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22632 arsenic molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22652 ascorbic acid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22653 asparagine An alpha-amino acid that has formula C4H8N2O3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22660 aspartic acid An alpha-amino acid that has formula C4H7NO4. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22727 benzopyran Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22823 beta-alanine derivative Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22860 amino-acid betaine Any amino acid-derived zwitterion - such as glycine betaine (N,N,N-trimethylammonioacetate) - in which the ammonium nitrogen carries three methyl substituents. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22881 biopterins Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22916 boron molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:22985 calclium molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23042 carotene Hydrocarbon carotenoids. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23044 carotenoid One of a class of tetraterpenoids (C40), formally derived from the acyclic parent, psi,psi-carotene by hydrogenation, dehydrogenation, cyclization, oxidation, or combination of these processes. This class includes carotenes, xanthophylls and certain compounds that arise from rearrangement of the skeleton of psi,psi-carotene or by loss of part of this structure. Retinoids are excluded. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23045 carotenol Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23117 chlorine molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23217 cholines Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23229 chromanol Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23230 chromanes Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23237 chromium molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23324 citrullines Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23333 cob(III)alamins Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23334 cobalamins Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23341 cobamides Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23367 molecular entity Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23377 copper molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23390 cobalt-corrinoid hexaamide Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23849 diterpenoid Any terpenoid having a C20 skeleton, derived from geranylgeranyl phosphate. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:23899 eicosanoid Any member of the group of signalling molecules arising from oxidation of the three C20 essential fatty acids (EFAs) eicosapentaenoic acid (EPA), arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA). Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24062 fluorine molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24431 chemical entity A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24471 halogen molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24532 organic heterocyclic compound A cyclic compound having as ring members aroms of carbon and at least one other element. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24610 homocysteines Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24612 homocystines A class of modified amino acids obtained by oxidative dimerisation of homocysteine and its derivatives. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24651 hydroxides Hydroxides are chemical compounds containing a hydrohy group or salts containing hydroxyde (OH(-)). Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24833 oxoacid A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24835 inorganic molecular entity A molecula entity that contains no carbon. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24860 iodine molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24870 ion A molecular entity having a net electric charge. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24873 iron molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24898 No ChEBI definition, for now, but: Isoleucine is an alpha-amino acid that has formual C6H13NO2, present in nature in one enantiomeric form (2S,3S)-2-amino-3-methylpenatanoic acid. [Source: http://en.wikipwdia.org/wiki/isoleucine isoleucine Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24913 isoprenoid Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24963 ketoaldonic acid Oxo carboxylic acids fromally derived from aldonic acid by replacement of a secondary CHOH group by a carbonyl group. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:24995 lactam Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one- structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25017 leucine A branched amino acid that has formula C6H13NO2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25048 linolenic acid Any of two trienoic essential fatty acids; a nutrient essential to the formation of prostaglandins. Also used in making paints and synthetic resins. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25094 lysine A diamino acid that has formula C6H14N2O2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25108 magnesium molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25154 manganese molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25359 modified amino acid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25362 elemental molecule A molecule all atoms of which have the same atomic number. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25370 molybdenum molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25481 naphtoquinone Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25627 octadecadienoic acid Any straight-chain, C18 polyunsaturated fatty acid having two C=C double bonds. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25693 organic heteromonocyclic compound Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:25848 pantothenic acids A class of amides formed from pantoic acid ansd beta-alanine and its derivatives. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26082 phosphorus molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26208 polyunsaturated fatty acid A fatty acid containing more than one double bond. Acids in this group are reported to have cardioprotective effects; and levels are lowered in chronic fatigue syndrome. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26217 potassium molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26373 pteridines Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26375 pterins Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26416 pyridine alkaloid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26420 pyridinemonocarboxylic acid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26421 pyridines Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26469 quaternary nitrogen compound A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26537 retinoid Oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26628 selenium molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26677 silicon molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26712 sodium molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26835 sulfur molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26873 terpenoid Any natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the same manner as are terpenes. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26932 tetrapyrrole A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26935 tetraterpenoid A terpenoid having a C40 skeleton. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26948 thiamine Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:26986 threonine Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27013 tocopherol A collective name for a group of closely related lipids that contain substitutions on the 3,4-dihydro-2H-chromen-6-ol nucleus and a hydrocarbon chain consisiting of three isoprenoid units. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27171 organic heterobicyclic compound Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27208 unsaturated fatty acid Any fatty acid containing at least one C-C unsaturated bond. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27266 valine A branched-chain amino acid that has formula C2H11NO2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27275 vanadium molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27300 vitamin D Vitamin D is a group of fat-soluble prohormones, which can be obtained from sun exposure, food and supplements. Vitamin D is biologically inactive and converted to the biologically active calcicitriol via double hydroxylation in the body. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27306 vitamin B6 Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27325 xanthophyll A subclass of carotenoids consisting of the oxygenated carotenes. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27364 zinc molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27432 alpha-linolenic acid A C18, omega-3 essential fatty acid with cis-double bonds at positions 9, 12 and 15. Shown to have antithrombotic effect. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27470 folic acid Folic acid is a form of the water-soluble vitamine B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosythesis and homocysteine remethylation. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27570 An amino acid which is also an imidazole. histidine An imidazole that has formula C6H9N3O2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27740 gamma-carotene A cyclic carotete that has formula C40H56. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:27897 tryptophan An aminoalkylindole that has formula C11H12N2O2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:28044 phenylalanine An aromatic amino acid that has formula C9H11NO2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:28125 docosahexaenoic acid A C22, omega-3, polyunsaturated essential fatty acid with double bonds at positions 4, 7, 10, 13, 16 and 19. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:28300 glutamine An alpha-amino acid that has formula C5H10N2O3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:28384 vitamin K A fat-soluble vitamin required for the synthesis of prothrombin and certain other blood coagulation factors. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:28425 alpha-carotene A cyclic carotete that has formula C40H56. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:28934 vitamin D2 A seco-ergostane that has formula C28H44O. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:28940 calciol A seco-cholestane that has formula C27H44O. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:29016 arginine An alpha-amino acid that has formula C6H14N4O2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:29073 L-ascorbic acid The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:30411 cobalamin A cobalt-corrinoid hexaamide that is cobalamin with the oxidation state of the central cobalt atom unspecified. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:30527 flavin A derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33234 vitamin E Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33235 tocotrienol Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33259 elemental molecular entity A molecular entity all atoms of which have the same atomic number. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33296 alkali metal molecular entity Molecular entity containing one or more of an alkali metal. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33299 alkaline earth molecular entity An alkaline earth molecular entity is a molecular entity containing one or more atoms of an alkaline earth metal. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33302 pnictogen molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33304 chalcogen molecular entity Any p-block molecular entitiy containing a chalcogen. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33497 transition element molecular entity A molecular entity containing one or more atoms of a transition element. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33575 carboxylic acid An oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33579 main group molecular entity A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, or 18 of the periodic table. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33581 boron group molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33582 carbon group molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33595 cyclic compound Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33635 polycyclic compound Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33672 heterobicyclic compound A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33673 zinc group molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33674 s-block molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33675 p-block molecular entity A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33676 d-block molecular entity A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33694 biomacromolecule A macromolecule formed by a living organism. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33695 information biomacromolecule Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33696 nucleic acid A macromolecule made up of nucleotide units and hydrolyzable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33702 polyatomic cation A cation consisiting of more than one atom. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33704 alpha-amino acid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33709 amino-acid A carboxylic acid containing one or more amino groups. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33720 carbohydrate acid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33741 chromium group molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33743 manganese group molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33744 iron group molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33745 copper group molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33746 vanadium group molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33747 nickel group molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33748 nickel molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33833 heteroarene A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2). Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33839 macromolecule A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33906 cobalt corrinoid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:33913 corrinoid A derivative of the corrin nucleus, which contains four reduced or partly reduced pyrrole rings joined in a macrocycle by three =C- groups and one direct carbon-carbon bond linking alpha positions. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35106 nitrogen hydride Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35107 azane Saturated acyclic nitrogen hydrides having the genral formula NnHn+2. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35163 cyclic carotene Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35186 terpene A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH2=C(CH3)CH=CH2]. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35193 tetraterpene A C40 terpene. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35267 quaternary ammonium ion A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually hydrocarbyl) groups. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35284 ammonium betaine Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35341 steroid Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from triterpenoids. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35350 hydroxy steroid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35366 fatty acid Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35724 ammonium ion Ammoium, NH4(+), and derivatives formed by substitution by univalent groups. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:35788 seco-steroid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36005 docosahexaenoic acids Any C22 polyunsaturated fatty acid containing six double bonds. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36006 eicosapentaenoic acid Any straight-chain, C20 polyunsaturated fatty acid having five C=C double bonds. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36141 quinone Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included). Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36309 cyclic tetrapyrrole Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36357 polyatomic entity Any molecular entity consisting of more than one atom. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36819 seco-ergostane Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36853 hydroxy seco-steroid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36916 cation A monoatomic or polyatomic species having one or more elementary charges of the proton. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36962 organochalcogen compound An organochacogen is a compound containing at leats one carbon-chalcogen bond. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:36963 organooxygen compound An organochacogen is a compound containing at leats one carbon-oxygen bond. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:37445 folate A group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:37577 heteroatomic molecular entity A molecular entity consisting of two or more chemical elements. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:37793 amino sulfonic acid An organosulfonic acid containing one or more amino groups. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:38101 organonitrogen heterocyclic compound Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:38263 2-amino-3-hydroxybutanoic acid An alpha-amino acid that has formula C4H9NO3. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:38295 azabicycloalkane Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:38418 1,3-thiazole Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:38443 1-benzopyran Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:38925 benzopteridine Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:39437 tocol Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:48901 thiazoles Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:50047 organic amino compound A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:50211 retinol A retinoid that has formula C20H30O. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:50401 cholestanoid Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:50860 organic molecular entity Any molecular entity that contains carbon. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:51143 nitrogen molecular entity Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:51570 biotins Compounds containing a biotin (5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid) skeleton. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:51958 oragnic polycyclic compound Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:52625 inorganic hydroxy compound Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:5686 heterocyclic compound A cyclic compound having as ring members atoms of at least two different elements. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:57589 O-acetyl-L-carnitine (R)-Acetylcarnitine Acetylcarnitine IUPAC name: (3R)-3-Acetoxy-4-(trimethyammonio)butanoat L-Acetylcarnitine acetyl-L-carnitine acetyl-carnitine An ammonium betaine arising from deprotonation of the carboxylic acid group of O-acetylcarnitinium. It facilitates movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). Lab abbreviation C2 [SN:2014-04-15] CHEBI:59202 straight-chain fatty acid A fatty acid whose skeletal carbon atoms form an unbranched open chain. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:59560 "Kuvan" is a brand name denoting saproptering as a drug for BH4 deficiencies. sapropterin A tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer). Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:61697 fatty acid derivative Any organic molecular entity derived from a fatty acid. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:70749 O-hexanoylcarnitine Hexanoyl-DL-carnitine IUPAC name: 3-(Hexanoyloxy)-4-(trumethylammonio)butanoate hexanoylcarnitine An O-acylcarnitine compound having hexanoyl as the acyl substituent. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). Lab abbreviation C6 [SN:2014-04-15] ONSTR needs O-hexanoyl-L-carnitine, not the Hexanoyl-DL-carnitine. It is O-hexanoyl-L-carnitine that is a secondary metabolite, aka fatty acid-acyl ester of L-carnitine (aka (R)-carnitine) and not of D-carnitine (aka (S)-carnitine) and not the racemic mixture (the DL-) of these two. O-hexanoylcarnitine covers both the D- and L-hexanoylcarnitines and we need only L-hexanoylcarnintine. Will have to correct this at a later date.[SN:2014-04-16]. CHEBI:75659 O-acyl-L-carnitine An O-acylcarnitine in which the carnitine component has L-configuration. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). CHEBI:7916 pantothenic acid The amide formed from pantoic acid and beta-alanine. Curation status: Imported from Chemical Entities of Biological Interest (ChEBI). ERO:0000185 high performance liquid chromatography A liquid chromatography technique that can separate a mixture of compounds and is used in biochemistry and analytical chemistry to identify, quantify and purify the individual components of the mixture. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0000721 data entry A data transformation technique that involves transcribing some form of data into another form, usally a computer program. Curation status: Imported from the Eagle-i Research Resource Ontology (ERO). Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0000722 patient screening A clinicl assay that is performed as a preliminary procedure, such as a test or examination, to detect the most characteristic sign or signs of a disorder or a condition that may require further investigation. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0000833 molecular assay An assay that generates data about the presence, abundance, structure, function, or activity of biological molecules, or a process at a molecular level of granularity. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001239 spectrophotometry A molecular assay is the quantitative measurement of the reflection or transmission properties of a material as a function of wavelenght. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001285 organismal assay An assay that generates data about the physical characteristics, physiological functions, or behavior or organisms or viruses. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001288 clinical assay An organismal assay designed to capture information about clinical samples or specimens. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001292 physiological assay An organismal assay designed to capture information pertaining to the organic precesses and phenomena of an organism or any of its parts or of a particular bodily process. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001329 liquid chromatography-mass spectrometry A mass spectrometry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry. Generally its application is oriented towards the specific detection and potential identification of chemicals in the presence of other chemicals (in a complex mixture). Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001332 capillary electrophoresis An electrophoresis thechnique used to separate ionic species by their charge and frictional forces and hydrodynamic radius. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001349 liquid chromatography-tandem mass spectrometry A liquid chromatography-mass spectrometry technique in which high-performance liquid chromatograohy is linked directly to a tandem mass spectrometer through electrospray ionization. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001354 inductively coupled plasma mass spectrometry ICP-MS ICP/MS A mass spectrometry technique that is highly sensitive and capable of the determination of a range of metals and several non-metals at concentrations below one part in 1012 (part per trillion). It is based on coupling together an inductively coupled plasma as a method of producing ions (ionization) with a mass spectrometer as a method of separating and detecting the ions. Curation status: Imported from the Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001362 immunoassay An assay that enables the presence or the concentartion of a substance in a material to be measured by exploiting the specific binding between an analyte and the corresponding detection antibody. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001439 atomic absorption spectroscopy AAS A molecular assay used for the qualitative and quantitative determination of chemical elements employing the absorption of optical radiation (light) by free atoms in the gaseous state. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001498 gas chromatography A chromatography technique that is used for separating and analyzing compounds that can be vaporized without decomposition. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001500 liquid chromatography A chromatography technique in which the mobile phase is a liquid and is carried out either in a column or a plane for the purpose of separating mixtures. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001501 ion chromatography ion-exchange chromatography A chromatography technique that allows the separation of ions and polar molecules based on their charge. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). ERO:0001784 pulse oximetry A physiological assay used to monitor the saturation of a patient's hemoglobin. Curation status: Imported from Eagle-i Research Resource Ontology (ERO) Note: This class may be replaced by a corresponding OBI class at a later date (if/when one is asserted in OBI). IAO:0000003 measurement unit label A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure. Curation status: Imported from Information Artifac Ontology (IAO). IAO:0000005 objective specification An objective specification is an information entity about a realizable entity that describes a intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved. Curation status: Imported from Information Artifact Ontology (IAO). purpose of a study; support of hypothesis, discovery of new information IAO:0000007 action specification An action specification is information about a realizable that describes an action the bearer will take Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000009 datum label A label is a symbol that is part of some other datum and is used to either partially define the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label Curation status: Imported from Information Artifac Ontology (IAO). IAO:0000010 software Software is a plan specification composed of a series of instructions that can be interpreted by or directly executed by a processing unit. Curation status: Imported from the Information Artifact Ontology (IAO) IAO:0000027 Data items include counts of things, analyte concentrations, and statistical summaries. data item data A data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. Curation status: Imported from Information Artifact Ontology (IAO) IAO:0000028 symbol Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000030 information content entity An information content entity is an entity that is generically dependent on some artifact and stands in relation of aboutness to some entity. Curation status: Imported from Information Artifact Ontology (IAO) Examples of information content entites include journal articles, data, graphical layouts, and graphs. IAO:0000032 scalar measurement datum a scalar measurement datum is a measurement datum that is composed of two parts, a single numeral and a unit label. Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000033 directive information entity An information content entity whose concretizations indicate to their bearer how to realize them in a process. Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000038 graph A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way. Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000088 report A document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record). Curation status: Imported from the Information Artifact Ontology (IAO) IAO:0000100 data set A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data set. Curation status: Imported from Information Artifact Ontology (IAO) IAO:0000101 image An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface. Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000104 plan specification A directive information entity that when concretized it is realized in a process in which the bearer tries to achieve the objectives, in part by taking the actions specified. Plan specifications includes parts such as objective specification, action specifications and conditional specifications. Curation status: Imported from the Information Artifact Ontology (IAO) IAO:0000109 measurement datum A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by an instrument. Curation status: Imported from Information Artifact Ontology (IAO). Examples of measurement data are the recoding of the weight of a mouse as {40,mass,"grams"}, the recording of an observation of the behavior of the mouse {,process,"agitated"}, the recording of the expression level of a gene as measured through the process of microarray experiment {3.4,luminosity,}. IAO:0000300 textual entity A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc. Curation status: Imported from the Information Artifact Ontology (IAO) IAO:0000303 institutional identification A textual entity intended to identify a particular institution. Curation status: Imported from Information Artifact Ontology (IAO) IAO:0000308 figure An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something. Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000309 diagram A figure that expresses one or more propositions Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000310 document A collection of information content entities intended to be understood together as a whole. Curation status: Imported from the Information Artifact Ontology (IAO) IAO:0000408 length measurement datum A scalar measurement datum that is the result of measurement of length quality Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000414 mass measurement datum A scalar measurement datum that is the result of measurement of mass quality Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000416 time measurement datum A scalar measurement datum that is the result of measuring a temporal interval Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000422 postal address A textual entity that is used as directive to deliver something to a person, or organization. Curation status: Imported from the Information Artifact Ontology (IAO). IAO:0000573 line graph A line graph is a type of graph created by connecting a series of data points together with a line. Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000577 CRID symbol A symobl that is part_of a CRID and that is sufficient to look up a record from the CRID's registry. Curation status: Imported from Information Artifact Ontology (IAO) IAO:0000578 CRID An information content entity that consists of a CRID symbol and additional information about which CRID registry it belongs. Curation status: Imported from the Information Artifact Ontology (IAO). IAO:0000579 CRID registry A CRID registry is a data set of CRID records, each consisting of a CRID symbol and additional information which was recorded in the dataset through a assigning a centrally registered identifier process. Curation status: Imported from Information Artifact Ontology (IAO) IAO:0000582 time stamped measurement datum Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000584 time sampled measurement data set A data set that is an aggregate of data recording some measurement at a number of time points. The time series data set is an ordered list of pairs of time measurement data and the corresponding measurement data acquired at that time. Curation status: Imported from Information Artifact Ontology (IAO). IAO:0000590 The qualifier "written" is to set it apart from spoken names. Also, note the restrictions to particulars. We are not naming universals. We could however, be naming, attributive collections which are particulars, so "All people located in the boundaries of the city of Little Rock, AR on June 18, 2011 at 9:50a CDT" would be a name. [Comment source: obo:IAO_0000590 ] written name A textual entity that denotes a particular in reality. Curation status: Imported from Information Artifact Ontology (IAO) IAO:0000594 software application A software application is software that can be directly executed by some processing unit. Curation status: Imported from the Information Artifact Ontology (IAO) OBI:0000011 Definition source: http://purl.obolibrary.org/obo/OBI_0000011 planned process A processual entity that realizes a plan which is the concretization of a plan specification. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000015 biological feature identification objective Biological feature identification objective is an objective role carried out by the proposition defining the aim of a study designed to examine or characterize a particular biological feature. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000034 supernatant role supernatant role is a role which inheres in a material entity and is realized by a material separation process using gravitational force in which the material bearing the supernatant role is the liquid component of the output material. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). Precipitation is the formation of a solid in a solution during a chemical reaction. When the reaction occurs, the solid formed is called the precipitate, and the liquid remaining above the solid is called the supernate. Wikipedia OBI:0000040 drug role A role borne by a molecular entity and is realized in a process of absorption by an organism alters, or effects (or is assumed to effect) a function(s) which inhere in an organism Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000047 processed material Is a material entity that is created or changed during material processing. Curation status: Imported from Ontology for Biomedical Investigations (OBI) OBI:0000067 evaluant role A role that inheres in an entity that is realized in an assay in which data is generated about the bearer of the evaluant role Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000068 reporting party role a study personnel role played by a party who reports the outcome of a study component Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000070 assay A planned process with the objective to produce information about some evaluant. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000075 diagnosis textual entity diagnosis is an assessment of a disease or injury, its likely prognosis and treatment. Curation status: Imported from the Ontology for Biomedical Investigations (OBI). Note[SN2013-02-09]: OGMS also has a term diagnosis (OGMS:0000073). It's NL definition says that it is a 'representation of a conclusion...', but it does not say what kind of representation it is, a textual representation (written), verbal representation (spoken/dicated). For the time being (2013-02-09), we are using OBI's classes 'perfroming and diagnosis' and 'textual diagnosis', because the have been linked by 'is specified output of'. We may swithc to OGMS classes at a later date. OBI:0000094 material processing A planned process which results in physical changes in a specified input material. Curation status: Imported from the Ontology for Biomedical Investigations (OBI) OBI:0000097 study subject role study subject role inheres in an entity and realized through the execution of a study design in which the entity participates by being that which the results are about. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). Human subjects in a clinical trial, rats in a toxicogenomics study, tissue cutlures subjected to drug tests, fish observed in an ecotoxicology study. Parasite example people infected, then extract parasite which are then tested = observation study of the parasite 1 study in which we observe people and 1 study in which subject is parasite is one way to split this. the true definition will come from the study design specification. OBI:0000102 responsible party role A study personnel role played by a party who is accountable for the execution of a study component and can make decisions about the conduct of the study Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000103 principal investigator role A responsible party role played by a person responsible for the overall conduct of a study Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000112 specimen role A role borne by a material entity that is gained during a specimen creation process and that is realized by use of the specimen in an investigation. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000116 worker role A personnel role played by a party who executes a component of the study plan; this can occur before, during, after or outside the study timeline Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000145 pathologist role A worker role of being responsible for making the histopathology diagnoses associated with data from a study; this activity occurs outside the study timeline Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000174 study group role a study population role where the bearer is a population of material entities and the role is realized in the implementation of a study design wherein the entities bearing the study population role are observed or subjected to intervention according to the study design and are biological replicates, i.e. they receive the same treatment under the protocol Curation status: Imported from the Ontology for Biomedical Investigation (OBI). The group of randomized participants that are assigned to a treatment arm of the trial OBI:0000201 radioactivity detection An assay in which a material radioactivity is measured. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000202 investigation agent role Investigation agent role is a role borne by a person or organization which is realized in a process that is part of an investigation in which an objective is achieved. These processes include: planning, overseeing, funding, reviewing. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000204 nutrient role A role that inheres in a material entity and is realized in the use of that material entity by an organism when it is used in that organism's metabolism and provides nourishment. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000224 sub-investigator role A worker role authorized to make study-related decisions and carry out tasks related to the study; this role occurs during the study timeline Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000234 trial statistician role A worker role that analyzes data obtained during a trial or study; this role occurs after the trial or study is completed or terminated. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000243 sponsor role A responsible party role involved with any of the following activities: initiating, managing and funding a study Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000268 organism feature identification objective Organism feature identification objective is a biological_feature_identification_objective role describing a study designed to examine or characterize a biological feature monitored at the level of the organism, e.g. height, weight, stage of development, stage of life cycle. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000272 protocol A protocol is a plan specification which has sufficient level of detail and quantitative information to communicate it between domain experts, so that different domain experts will reliably be able to independently reproduce the process. Curation status: Imported from the Ontology for Biomedical Investigations (OBI) OBI:0000274 adding a material entity into a target is a process with the objective to place a material entity bearing the 'material to be added role' into a material bearing the 'target of material addition role'. Curation status: Imported from the Ontology for Biomedical Investigations (OBI) OBI:0000275 analyte role Analyte role is a role borne by a molecular entity and realized in an analyte assay which achieves the objective to measure the magnitude/concentration/amount of the analyte in the entity bearing evaluant role Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000318 eluate an eluate is a material entity which results from an elution, e.g. from a chromatography column. it has as part a material entity with role mobile phase Curation status: Imported from the Ontology for Biomedical Investigations (OBI) OBI:0000319 material to be added role material to be added role is a protocol participant role realized by a material which is added into a material bearing the target of material addition role in a material addition process Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000338 interpreting data The process of evaluating the data gathered in an investigation in the context of literature knowledge with the objective to generate more general conclusions or to identify what additional data is necessary to draw conclusions. Curation status: Imported from the Ontology for Biomedical Investigations (OBI). OBI:0000366 metabolite profiling Metabolite profiling is a process which aims at detecting and identifying chemical entities resulting from biochemical and cellular metabolism. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000437 analyte measurement objective Analyte measurement objective is an assay objective to determine the presence or concentration of an analyte in the evaluant Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000441 assay objective Assay objective is the specification of an objective to determine a specified type of information about an evaluated entity (independent continuant bearing evaluant role) Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000443 analyte assay An assay with the objective to capture information about the presence, concentration, or amount of an analyte in an evaluant. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000444 target of material addition role target of material addition role is a role realized by an entity into which a material is added in a material addition process Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000445 mass measurement assay A process to determine the mass of an evaluant. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000470 mass spectrometry assay This is a measuring method consisting of turning elements in a sample into ions, isolating them according to the ratio between the mass and charge numbers and detecting it electrically. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000520 clinical chemistry assay A process which uses analytical methods to produce measurements and data on the concentration of a chemical parameters (analytes) present in a bodily fluid collected from an organism. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000651 urine specimen A portion of urine collected from an organism. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000652 material combination is a material processing with the objective to combine two or more material entities as input into a single material entity as output. Curation status: Imported from the Ontology for Biomedical Investigations (OBI) OBI:0000655 blood specimen A material entity derived from a portion of blood collected from an organism. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000659 specimen creation A planned process with the objective of obtaining specimen. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000661 ELISA Enzyme-Linked ImmunoSorbent Assay ELISA is an assay where an enzyme linked antibody is used to detect a plate bound material in a liquid (the evaluant) utilizing a chemiluminescent reaction. The detected signal is proxy for the concentration of an analyte in the evaluant. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). Note: This class may be moved under immuno assay, if/when team OBI asserst one OBI:0000679 average value A data item that is produced as the output of an averaging data transformation and represents the average value of the input data. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000684 specimen creation objective A specimen creation objective is to obtain a material entity for potential use as an input during an investigation Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000718 pathogen role pathogen role is a role which inheres in an organism and realized in the process of disease course in the organism bearing host role caused by the organism bearing pathogen role Curation status: Imported from the Ontology for Biomedical Investigation (OBI). Pathogen: An agent of disease. A disease producer. The term pathogen most commonly is used to refer to infectious organisms. These include bacteria (such as staph), viruses (such as HIV), and fungi (such as yeast). Less commonly, pathogen refers to a noninfectious agent of disease such as a chemical. http://www.medterms.com/script/main/art.asp?articlekey=6383 OBI:0000740 material sample role A material sample role is a specimen role borne by a material entity that is the output of a material sampling process. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). A role borne by a portion of blood taken to represent all the blood in an organism; the role borne by a population of humans with HIV enrolled in a study taken to represent patients with HIV in general. OBI:0000852 record of missing knowledge An information content entity created to indicate that information about something is not available to the person recording it. Curation status: Imported from the Ontology for Biomedical Investigations (OBI) OBI:0000910 radio immuno assay An assay in which a radioactive label is used to determine the interaction between an antigen and an anibody. This can be used to detect the presence of an antigen of interest or determine the specificity of an antibody. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000938 categorical measurement datum A measurement datum that is reported on a categorical scale Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000953 processed specimen A specimen that has been intentionally physically modified. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000963 categorical label A label that is part of a categorical datum and that indicates the category of that datum Curation status: Imported from the Ontology for Biomedical Investigation (OBI). The labels 'positive' vs. 'negative', or 'left handed', 'right handed', 'ambidexterous', or 'strongly binding', 'weakly binding' , 'not binding', or '+++', '++', '+', '-' etc. form scales of categorical labels. OBI:0000969 dose specification A directive information entity that describes the dose that will be administered to a target Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000970 scalar score from composite inputs Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000976 handedness categorical measurement datum A datum used to record the answer to a self assessment of whether a person uses their left hand, right hand primarily or each hand equally Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000984 dose A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000988 performing a diagnosis The interpretation of the information available about bodily features (clinical picture) of a patient resulting in a diagnosis. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0000991 Edinburgh score Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0001141 individual organism identifier A symbol used to distinguish one individual organism from another. Curation status: Imported from Information Artifact Ontology (IAO) OBI:0001158 age measurement assay An assay that measures the duration of temporal interval of a process that is part of the life of the bearer, where the initial time point of the measured process is the beginning of some transitional state of the bearer such as birth or when planted. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0001167 age measurement datum A time measurement datum that is the result of measurement of age of an organism Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0001169 age since birth measurement datum An age measurement datum that is the result of the measurement of the age of an organism since birth, the process of emergence and separation of offspring from the mother. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0001305 genotype information A genetic characteristics information that is about the genetic material of an organism and minimally includes information about the genetic background and can in addition contain information about specific alleles, genetic modifications, etc. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0001352 allele information A genetic alteration information that about one of two or more alternative forms of a gene or marker sequence and differing from other alleles at one or more mutational sites based on sequence. Polymorphisms are included in this definition. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0001364 genetic alteration information A genetic characteristics information that is about known changes or the lack thereof from the genetic background, including allele information, duplication, insertion, deletion, etc. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0001404 genetic characteristics information A data item that is about genetic material including polymorphisms, disease alleles, and haplotypes. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0001619 specimen creation measurement datum A time measurement datum that is the measure of the time when the specimens are collected. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0001672 country name A textual entity that denotes a geographic location that is a site or part of a site that is identified as a country in the political geography. Curation status: Imported from Ontology for Biomedical Investigations (OBI) OBI:0001683 fluorescence in-situ hybridization is an in-situ hybridization assay that uses fluorescence as means of detection chromosomal integrity. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0100016 blood plasma specimen A material entity which corresponds to the liquid component of blood, in which the blood cells are suspended. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0100017 blood serum specimen A material entity which derives from blood and corresponds to blood plasma without fibrinogen or the other clotting factors. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0100051 specimen A material entity that has the specimen role. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0200000 data transformation A data transformation is a process which produces output data from input data. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0200082 longitudinal data analysis Longitudinal analysis is a data transformation used to perform repeated observations of the same items over long periods of time. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0200085 mass spectrometry analysis A data transformation which has the objective of spectrum analysis. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0200166 data transformation objective A data transformation objective is an objective specification that a data transformation may have towards which the realization of that transformation is directed. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0200198 tandem mass spectrometry Tandem mass spectrometry is a data transformation that uses two or more analyzers separated by a region in which ions can be induced to fragment by transfer of energy (frequently by collision with other molecules). Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0302732 solvent role Solvent role is a role which inheres in a molecular entity capable of ensuring the dissolution of another chemical entity and realized by the process of solvation Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0302733 solute role Solute role is a role played by a chemical entity which is dissolved by another chemical entity (the solvent) when creating a solution Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0302905 elution the process of extracting one material from another by washing with a solvent to remove adsorbed material from an adsorbent (as in washing of loaded ion-exchange resins to remove captured ions) Curation status: Imported from the Ontology for Biomedical Investigations (OBI) OBI:0500000 study design A study design is a plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution. Curation status: Imported from the Ontology for Biomedical Investigations (OBI) OBI:0600003 performing clinical assessment A protocol application during which a series of tests are made of a patient leading to determination of disease state, or condition. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0600005 collecting specimen from organism A process with the objective to obtain a material entity that was part of an organism for potential future use in an investigation. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). OBI:0600007 administering substance in vivo A process by which a substance is intentionally given to an organism. Curation status: Imported from the Ontology for Biomedical Investigations (OBI) OBI:0600014 material component separation A material processing in which components of an input material become segregated in space. Curation status: Imported from the Ontology for Biomedical Investigations (OBI). OBI:0600046 preparative chromatography The use of a biomaterial's preferential affinity for either the mobile phase or the stationary phase to separate it from other materials of differing affinity. Curation status: Imported from the Ontology for Biomedical Investigations (OBI). OBI:0600053 electrophoresis A protocol application that uses an electrical potential to move material through a defined matrix in order to separate it by its resistance to movement and its charge. Curation status: Imported from the Ontology for Biomedical Investigations (OBI). OGMS:0000014 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf clinical finding A representation that is either the output of a clinical history taking or a physical examination or an image finding, or some combination thereof. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000015 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf clinical history A series of statements representing health-relevant qualities of a patient and of a patient's family. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000017 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf image finding A clinical finding that is a representation of an image that supports an inference to an assertion about some quality of a patient. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000018 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf laboratory finding A clinical finding that is a representation of a quality of a specimen that is the output of a laboratory test and that can support an inference to an assertion about some quality of the patient. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000023 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf phenotype A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000031 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf disease A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000035 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf constitutional genetic disease A disease whose physical basis is a constitutional genetic disorder. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000045 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf disorder A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000047 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf genetic disorder A disorder whose etiology involves an abnormality in the nucleotide sequence of an organism's genome. Curation status: Imported OGMS:0000051 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf constitutional genetic disorder A genetic disorder inherited during conception that is part of all cells in the organism. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000055 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf clinical history taking An interview in which a clinician elicits a clinical history from a patient or from a third party who is reporting on behalf of the patient. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000056 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf laboratory test A measurement assay that has as input a patient-derived specimen, and as output a result that represents a quality of the specimen. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000057 Definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf physical examination A sequence of acts of observing and measuring qualities of a patient performed by a clinician; measurements may occur with and without elicitation. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000060 bodily process Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000061 pathological bodily process A bodily process that is clinically abnormal. Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000090 Definition source: http://code.google.com/p/ogms/issues/detail?id=35 treatment treatment process A processual entity whose completion is hypothesized (by a healthcare provider) to alleviate the signs and symptoms associated with a disorder Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000096 Definition source: http://groups.google.com/group/ogms-discuss/browse_thread/thread/a2dbc2ed1dff99d6 health care process A social process that has at least one human participant and that includes as parts the treatment, diagnosis, or prevention of disease or injury--or the following of instructions of another human for treatment, diagnosis, or prevention--of a participant in the process Curation status: Imported from the Ontology for General Medical Science (OGMS). OGMS:0000097 http://groups.google.com/group/ogms-discuss/browse_thread/thread/a2dbc2ed1dff99d6 health care encounter A temporally-connected health care process that has as participants an organization or person realizing the health care provider role and a person realizing the patient role. The health care provider role and patient are realized during the health care encounter Curation status: Imported from the Ontology for General Medical Science (OGMS). OMRSE:00000010 human health care role A human social role that is realized by health care processes such as seeking or providing treatment for disease and injury, diagnosing disease and injury, or undergoing diagnosis. Curation status: Imported from the Ontology for Medically Related Social Entities (OMRSE). OMRSE:00000011 patient role A role borne by an organism being as the recipient of a health care service. Curation status: Imported from the Ontology for Medically Related Social Entities (OMRSE). OMRSE:00000012 health care provider role A human health care role inhering in an organization or human being that is realized by a process of providing health care services to an organism. Curation status: Imported from the Ontology for Medically Related Social Entities (OMRSE). OMRSE:00000013 physician role A health care role borne by a human being and realized by promoting, maintaining or restoring human health through the study, diagnosis, and treatment of disease, injury and other physical and mental impairments. Curation status: Imported from the Ontology for Medically Related Social Entities (OMRSE). OMRSE:00000014 nurse role A health care role borne by a human being and realized by the care of individuals, families, and communities so they may attain, maintain, or recover optimal health and quality of life. Curation status: Imported from the Ontology for Medically Related Social Entities (OMRSE). OMRSE:00000018 hospital role A role borne by an organization and realized by providing healthcare services by healthcare professionals of multiple different disciplines of medicine and enabling stationary treatment. Curation status: Imported from the Ontology for Medically Related Social Entities (OMRSE). OMRSE:00000024 role in human social processes A role inhering in an entity realized by social interactions in human society. Curation status: Imported from the Ontology for Medically Related Social Entities (OMRSE). UO:0000001 length unit A base unit which is a standard measure of the distance between two points. Curation status: Imported from the Unit Ontology (UO) UO:0000002 mass unit A base unit which is a standard measure of the amount of matter/energy of a physical object. Curation status: Imported from the Unit Ontology (UO) UO:0000045 base unit A unit which is one of a particular measure to which all measures of that type can be related. Curation status: Imported from the Unit Ontology (UO) UO:0000046 derived unit A unit which is derived from base units. Curation status: Imported from the Unit Ontology (UO) UO:0000051 concentration unit A derived unit which represents a standard measurement of how much of a given substance there is mixed with another substance. Curation status: Imported from the Unit Ontology (UO) UO:0000052 mass density unit mass per unit volume A density unit which is a standard measure of the mass of a substance in a given volume. Curation status: Imported from the Unit Ontology (UO) UO:0000054 area density unit mass per unit area A density unit which is a standard measure of the mass exerting an influence on a given area. Curation status: Imported from the Unit Ontology (UO) UO:0000061 unit of molarity A derived concentration unit which is a standard measure of the number of moles of a given substance per liter of solution. Curation status: Imported from the Unit Ontology (UO) UO:0000095 volume unit A derived unit which is a standard measure of the amount of space occupied by any substance, whether solid, liquid, or gas. Curation status: Imported from the Unit Ontology (UO) UO:0000111 energy unit A derived unit which is a standard measure of the work done by a certain force (gravitational, electric, magnetic, force of inertia, etc). Curation status: Imported from the Unit Ontology (UO) UO:0000126 temperature derived unit A derived unit which represents a standard measurement of temperature in a particular temperature scale. Curation status: Imported from the Unit Ontology (UO) UO:0000149 time derived unit A derived unit which is a standard measure of the dimension in which events occur in sequence. Curation status: Imported from the Unit Ontology (UO) UO:0000177 unit per volume unit A derived concentration unit which is a standard measure of the number of units, as an agreed arbitrary amount, of a given substance per a specific volume of solution. Curation status: Imported from the Unit Ontology (UO) UO:0000179 unit per liter U/l A unit per milliliter unit which is equal to one unit of an agreed arbitrary amount per one liter. Curation status: Imported from the Unit Ontology (UO) UO:0000182 density unit A derived unit which is a standard measure of the influence exerted by some mass. Curation status: Imported from the Unit Ontology (UO) UO:0000186 dimensionless unit A derived unit which is a standard measure of physical quantity consisting of only a numerical number without any units. Curation status: Imported from the Unit Ontology (UO) UO:0000187 percent % A dimensionless ratio unit which denotes numbers as fractions of 100. Curation status: Imported from the Unit Ontology (UO) UO:0000190 ratio A dimensionless unit which denotes an amount or magnitude of one quantity relative to another. Curation status: Imported from the Unit Ontology (UO) UO:0000200 cell concentration unit A concentration unit which denotes the average cell number in a given volume. Curation status: Imported from the Unit Ontology (UO) genotyping assay An assay which generates data about a genotype from a specimen of genomic DNA. A variety of techniques and instruments can be used to produce information about sequence variation at particular genomic positions. Curation status: Imported from the Ontology for Biomedical Investigation (OBI). PRO:PR_000000001 protein An amino-acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA. Curation status: Imported from Protein Ontology (PRO). PRO:PR_000003918 serum albumin A protein that is a translation product of the ALB gene or an 1:1 ortholog thereof. Curation status: Imported from Protein Ontology (PRO). PRO:PR_000012234 Note: In the literature, in the case of homomonomeric enzyme (protein) complexes, the same names are used for both monomers and corresponding protein complexes, e.g. phenylalanine-4-hydroxylase is interghangeably used both for catalytically inactive enzyme monomer and for catalytically active protein complex. This class name denotes the phenylalanine-4-hydroxylase enzyme monomer, *not* the phenylalanine-4-hydroxylase complex which is a homomonomer (a dimer or tetramer consisting of 2 or 4 phenylalanine-4-hydroxylase monomers) and which is the bearer of the phenylalanine-4-monoxygenase activity (GO:00016714). phenylalanine-4-hydroxylase 4-hydroxylase phenylalanine 4-monooxygenase, phenylalanine PAH Phe-4-monooxygenase PheH PheOH hydroxylase, phenylalanine phenylalaninase phenylalanine 4 hydroxylase phenylalanine 4 monooxygenase phenylalanine 4-monooxygenase phenylalanine 4-monooxygenase monomer phenylalanine hydroxylase phenylalanine-4-hydroxylase monomer A protein that is a translation product of the PAH gene or a 1:1 ortholog thereof. Curation status: Imported from the Protein Ontology (PRO). PRO:PR_00001626 serotransferrin serum transferrin transferrin A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof. Curation status: Imported from Protein Ontology (PRO). PRO:PR_000018263 amino-acid chain A polymer of amino-acids linked by peptide bonds. Curation status: Imported from the Protein Ontology (PRO). CL:CL_0000000 cell Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. Curation status: Imported from Cell Ontology (CL). CL:CL_0000003 cell in vivo Curation status: Imported Cell Ontology (CL). CL:CL_0000004 cell by organism A classification of cells by the organisms within which they are contained. Curation status: Imported from Cell Ontology (CL). CL:CL_0000066 epithelial cell A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. Curation status: Imported from Cell Ontology (CL). CL:CL_0000081 blood cell A cell found predominately in the blood. Curation status: Imported Cell Ontology (CL). CL:CL_0000094 granulocyte A leukocyte with abundant granules in the cytoplasm. Curation status: Imported from Cell Ontology (CL). CL:CL_0000182 hepatocyte The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. Curation status: Imported from Cell Ontology (CL). CL:CL_0000232 erythrocyte A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. Curation status: Imported from Cell Ontology (CL). CL:CL_0000233 platelet A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. Curation status: Imported from Cell Ontology (CL). CL:CL_0000255 eucaryotic cell Curation status: Imported from Cell Ontology (CL). CL:CL_0000542 lymphocyte A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. Curation status: Imported from Cell Ontology (CL). CL:CL_0000548 animal cell Curation status: Imported from Cell Ontology (CL). CL:CL_0000738 leukocyte An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. Curation status: Imported from Cell Ontology (CL). CL:CL_0000988 hematopoietic cell A cell of a hematopoietic lineage. Curation status: Imported Cell Ontology (CL). CL:CL_0002087 SN: This term has class-complement kind of label (non-xxx). It might be deprecated in later versions of CL. Need to keep an eye on this one. nongranular leukocyte A leukocyte that lacks granules. Curation status: Imported from Cell Ontology (CL). CL:CL_0002518 kidney epithelial cell An epithelial cell of the kidney. Curation status: Imported from Cell Ontology (CL). GO:GO_0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. Curation status: Imported from Gene Ontology (GO).. Note: Following GO Consortium, the instances of classes of GO:molecular_function hierarchy stand in parf_of relation to instances of GO:biological_process class hierarchy. As a consequnece of such intepretation in ONSTR, GO:molecular_function is placed under BFO:process, as an BFO:occurent, and NOT as a continuant subsumed under BFO:function, even though GO class name(s) may lead to be interpreted as such. [Source: The Gene Ontology Consortium. (2011) The Gene Ontology: enhancements for 2011. Nucleic Acid Research, 2011, Vol 40.] GO:GO_0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] Curation status: Imported from the Gene Ontology (GO). GO:GO_0004497 monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Curation status: Imported from the Gene Ontology (GO). GO:GO_0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. Curation status: Imported from Gene Ontology (GO).. GO:GO_0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. Curation status: Imported from Gene Ontology (GO).. GO:GO_0010467 gene expression The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. Curation status: Imported from Gene Ontology (GO). GO:GO_0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Curation status: Imported from the Gene Ontology (GO). GO:GO_0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. Curation status: Imported from the Gene Ontology (GO). GO:GO_0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. Curation status: Imported from the Gene Ontology (GO). GO:GO_0040007 growth The increase in size or mass of an entire organism, a part of an organism or a cell. Curation status: Imported from Gene Ontology (GO).. GO:GO_0043170 macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Curation status: Imported from Gene Ontology (GO).. GO:GO_0043234 protein complex protein-protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. Curation status: Imported from Gene Ontology (GO).. GO:GO_0048589 developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. Curation status: Imported from Gene Ontology (GO).. NCBITaxon:NCBITaxon_117570 Teleostomi Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_117571 Euteleostomi Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_131567 cellular organisms Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_207598 Homininae Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_2759 Eukaryota Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_314146 Euarchontoglires Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_314293 Simiiformes Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_314295 Hominoidea Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_32523 Tetrapoda Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_32524 Amniota Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_32525 Theria Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_33154 Opisthokonta Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_33208 Metazoa Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_33213 Bilateria Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_33316 Coelomata Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_33511 Deuterostomia Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_376913 Haplorrhini Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_40674 Mammalia Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_6072 Eumetazoa Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_7711 Chordata Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_7742 Vertebrata Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_7776 Gnathostomata Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_8287 Sarcopterygii Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_89593 Craniata Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_9347 Eutheria Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_9443 Primates Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_9526 Catarrhini Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_9604 Hominidae Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_9605 Homo Curation status: Imported from NCBITaxonomy NCBITaxon:NCBITaxon_9606 Homo sapiens Curation status: Imported from NCBITaxonomy PATO:PATO_0000011 age A time quality inhering in a bearer by virtue of how long the bearer has existed. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000025 Note: Definition for this term in PATO says "a single physical entity", while in fact it should say "a quality of single physical entity". This error is corrected in the definition provided in ONSTR. PATO examples: For example calcium composition (which may inhere in bone), haemoglobin composition (which may inhere in blood). composition compositionality [exact synonym in PATO] content [exact synonym in PATO] A quality of single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000033 concentration of concentration [exact synonym in PATO] A quality inhering in a substance by virtue of the amount of the bearer's that is mixed with another substance. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000047 biological sex An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000051 morphology A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000058 odor A physical quality inhering in a bearer by virtue of the bearer's molecules being are aerially dispersed and perceived by an odorant receptor. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000068 This one needs to be checked from time to time, as it may be obsoleted and its children moved. qualitative Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000069 deviation (from normal) A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000117 size A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000122 length A 1-D extent quality which is equal to the distance between two points. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000125 mass A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000141 structure relational structural quality [exact synonym in PATO] A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000161 rate A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000165 time A quality in which events occur in sequence. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000169 viability An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000186 behavioral quality An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation. Curation status: Imported PATO:PATO_0000261 maturity A quality of a single physical entity which is held by a bearer when the latter exhibits complete growth, differentiation, or development. Curation status: Imported from the Phenotypic Quality Ontology (PATO). PATO:PATO_0000383 female A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000384 male A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000455 pubescent A maturity quality inhering in a bearer by virtue of the bearer's having arrived at the onset of puberty (the age at which sex glands become functional) but not yet fully mature. Curation status: Imported from the Phenotypic Quality Ontology (PATO). PATO:PATO_0000460 abnormal A quality inhering in a bearer by virtue of the bearer's deviation from normal or average. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000461 normal A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000646 malformed A morphological quality inhering in a bearer by virtue of the bearer's being distorted during formation. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0000918 volume A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001018 physical quality relational physical quality [exact synonym in PATO] A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001159 concentrated A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001162 increased concentration high concentration [exact synonym in PATO] A concentration which is higher relative to the normal or average. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001163 decreased concentration low concentration [exact synonym in PATO] A concentration which is lower relative to the normal or average. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001186 prepubescent A maturity quality inhering in a bearer by virtue of the bearer's being at the age immediately before puberty. Curation status: Imported from the Phenotypic Quality Ontology (PATO). PATO:PATO_0001189 adolescent A maturity quality inhering in a bearer by virtue of the bearer's being between the onset of puberty and maturity. Curation status: Imported from the Phenotypic Quality Ontology (PATO). PATO:PATO_0001190 juvenile A maturity quality inhering in a bearer by virtue the bearer's being not fully grown or developed. Curation status: Imported from the Phenotypic Quality Ontology (PATO). PATO:PATO_0001236 process quality A quality which inheres in an process. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001241 Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. [Comment imported from Phenotypic Quality Ontology (PATO)..] This is a monadic (not a relational) quality that inheres in a single continuant. physical object quality quality of a single physical entity A quality which inheres in a continuant. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001331 odorous An odor quality inhering in a bearer by virtue of the bearer's having odor. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001340 hermaphrodite A biological sex quality inhering in an organism or a population with both male and female sexual organs in one individual. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001421 alive A viability quality inhering in a bearer by virtue of the bearer's condition before death. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001422 dead A viability quality inhering in a bearer by virtue of the cessation of the bearer's life. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001486 chronological age An age quality that exists by virtue of the time (years and months) that the bearer has existed. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001509 functionality A quality of a single physical entity that arises by virtue of whether the bearer exhibits the ability to perform a regular function(s). Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001510 functional A functionality quality held by the bearer when the latter is able to perform a regular function(s). Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001511 non-functional A disfunctional quality held by the bearer when the latter is unable to perform a regular function(s). Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001555 has number of The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001617 deformed A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001624 decreased functionality A functionality quality held by the bearer when the latter exhibits decreased ability to perform a regular function(s). Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001625 increased functionality A functionality quality held by the bearer when the latter exhibits increased ability to perform a regular function(s). Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001648 circumference An 1-D extent quality which is equal to the length of the closed curve of a circle. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001674 catalytic (activity) concentration A concentration quality inhering in a bearer by virtue of the bearer's catalytic activity divided by the volume of the system. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001701 mature A quality inhering in a bearer by virtue of the bearer's exhibiting complete growth, differentiation, or development. Curation status: Imported from the Phenotypic Quality Ontology (PATO). PATO:PATO_0001708 1-D extent 1-D size [exact synonym in PATO] A size quality inhering in an bearer by virtue of the bearer's extension in one dimension. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001710 3-D extent 3-D size [exact synonym in PATO] A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001711 perimeter An 1-D extent quality inhering in two-dimensional bearer by virtue of being equal to the distance around it. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001827 pseudohermaphrodite A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of one sex and external sexual characteristics of the other sex. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001828 male pseudohermaphrodite A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of male and external sexual characteristics of female. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001829 female pseudohermaphrodite A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of female and external sexual characteristics of male. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001869 pathological A quality inhering in a bearer by virtue of the bearer's being abnormal and having a destructive effect on living tissue. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001894 phenotypic sex Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001905 has normal number of parts of type The bearer of this quality has_part = n, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0001995 organismal quality A quality that inheres in an entire organism or part of an organism. Curation status: Imported from the Phenotypic Quality Ontology (PATO). PATO:PATO_0001999 lacks parts or has fewer parts of type The bearer of this quality has_part<n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0002000 lacks all parts of type A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0002062 physical quality of a process Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0002083 altered number of Having extra or fewer parts. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0002182 molecular quality relational molecular quality [exact synonym in PATO] A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0002201 handedness A behavioral quality inhering in a bearer by virtue of the bearer's unequal distribution of fine motor skill between its left and right hands or feet. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0002202 left handedness Handedness where the organism preferentially uses the left hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0002203 right handedness Handedness where the organism preferentially uses the right hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0002204 ambidextrous handedness Handedness where the organism exhibits no overall dominance in the use of right or left hand or foot in the performance of tasks that require one hand or foot or a dominant hand or foot. Curation status: Imported from Phenotypic Quality Ontology (PATO). PATO:PATO_0002206 neonatal A maturity quality inhering to a bearer by virtue of the bearer's being at the point or short after birth. Curation status: Imported from the Phenotypic Quality Ontology (PATO). SO:SO_0000001 region A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino-acids. Curation status: Imported from Sequence Ontology (SO). SO:SO_0000110 sequence_feature An extent of biological sequence. Curation status: Imported from Sequence Ontology (SO). This calss (SO:sequence_feature) is placed under BFO:quality (BFO_000019) following Mungall et al. 2011. (Mungall, C. J., Batchelor, C., Eilbeck, K. (2011) Evolution of the Sequence Ontology terms and relations. Journal of Biomedical Informatics, 2011 February; 44(1):87-93). SO:SO_0000704 gene A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. Curation status: Imported from Sequence Ontology (SO). SO:SO_0001203 allele An allele is one of a set of coexisting sequence variants of a gene. Curation status: Imported from Sequence Ontology (SO). SO:SO_0001207 genotype A genotype is a variant genome, complete or incomplete Curation status: Imported from Sequence Ontology (SO). SO:SO_0001217 protein_coding_gene Curation status: Imported from Sequence Ontology (SO). SO:SO_0001260 sequence_collection A collection of discontinuous sequences Curation status: Imported from Sequence Ontology (SO). SO:SO_0001411 biological_region A region defined by its disposition to be involved in a biological process. Curation status: Imported from Sequence Ontology (SO). SO:SO_0001507 variant_collection A collection of one or more sequences of an individual. Curation status: Imported from Sequence Ontology (SO). FMA:Anatomical_entity Anatomical entity Organismal continuant entity which is enclosed by the bona fide boundary of an organism or is an attribute of its structural organization. Examples: cell, heart, head, peritoneal cavity, apex of lung, anatomical term, sagittal plane. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Anatomical_structure Anatomical structure Material anatomical entity which is generated by coordinated expression of the organism's own genes that guide its morphogenesis; has inherent 3D shape; its parts are connected and spatially related to one another in patterns determined by coordinated gene expression. Examples: heart, right ventricle, mitral valve, myocardium, endothelium, lymphocyte, fibroblast, thorax, cardiovascular system, hemoglobin, T cell receptor. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Body Body Anatomical structure which is the aggregate material substance of an individual member of a species. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Body_of_vertebrate Body of vertebrate Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Brain Brain Segment of neuraxis that has as its parts gray matter and white matter that surround the cerebral ventricular system; Examples: There is only one brain. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Cardinal_body_part Cardinal body part Anatomical structure, which has as its direct parts instances of anatomical sets of organs and cardinal organ parts spatially associated with either the skull, vertebral column, or the skeleton of a limb; in their aggregate are surrounded by a part of the skin Examples: Head, body proper, right upper limb. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Cardinal_organ_part Cardinal organ part Anatomical structure which has as its direct parts two or more types of tissue and is continuous with one or more anatomical structures likewise constituted by two or more portions of tissues distinct from those of their complement. Examples: osteon, cortical bone, neck of femur, bronchopulmonary segment, left lobe of liver, anterior right side of heart, interventricular branch of left coronary artery, right atrium, mitral valve, head of pancreas. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Corticomedulary_organ Corticomedulary organ Parenchymatous organ the stroma of which subdivides the parenchyma into cortex and medulla. Examples: thymus, spleen, ovary. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Female_human_body Female human body Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Head Head Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the skull, it is partially surrounded by skin of head. Examples: There is only one head. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Human_body Human body Anatomical structure which is the aggregate material substance of an individual member of the human species. Examples: male human body and female human body. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Kidney Corticomedullary organ which has as its part renal pelvis shared with and connected to ureter. Examples: There are only two, right kidney and left kidney. Kidney Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Liver Liver Lobular organ which has as its parts lobules connected to the biliary tree. Examples: There is only one liver. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Lobular_organ Lobular organ Parenchymatous organ the stroma of which subdivides the parenchyma into lobes, segments, lobules and acini. Examples: lung, liver, lactiferous gland, testis. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Male_human_body Male human body Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Material_anatomical_entity Material anatomical entity Physical anatomical entity which has mass. Examples: hemoglobin molecule, mitochondrion, hepatocyte, erythrocyte, heart, head, blood, urine. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Organ Organ Anatomical structure which has as its direct parts portions of two or more types of tissue or two or more types of cardinal organ part which constitute a maximally connected anatomical structure demarcated predominantly by a bona fide anatomical surface. Examples: femur, biceps, liver, heart, skin, tracheobronchial tree, ovary. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Organ_region Organ region Cardinal organ part which is a fiat subdivision of an organ. Examples: lingula of left lung, tail of pancreas, artery, trochanter, nodulus of semilunar valve, right side of heart, duodenum, fundus of stomach. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Organ_segment Organ segment Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Parenchymatous_organ Parenchymatous organ Solid organ which consists of parenchyma and connective tissue stroma; the stroma subdivides the parenchyma into lobes, segments, lobules, acini, or cortex and medulla. Examples: lung, liver, spleen, kidney, parathyroid gland. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Physical_anatomical_entity Physical anatomical entity Anatomical entity which has three or fewer spatial dimensions. Examples: hemoglobin molecule, mitochondrion, hepatocyte, erythrocyte, heart, head, blood, urine, peritoneal cavity, diaphragmatic surface of heart, inferior margin of liver, apex of lung Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_arterial_blood Portion of arterial blood Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_blood Portion of blood Portion of body substance which consists of plasma and blood cells. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_blood_in_capillary Portion of blood in capillary Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_body_fluid Portion of body fluid Portion of body substance which has as its parts of a mixture of fluid, solutes and particles. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_body_fluid_solution Portion of body fluid solution Portion of body fluid which consists of water and solutes. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_body_fluid_suspension Portion of body fluid suspension Portion of body fluid which has as its parts portion of body fuild solution and particles. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_body_substance Portion of body substance Material anatomical entity in a gaseous, liquid, semisolid or solid state, with or without the admixture of cells and biological macromolecules; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures. Examples: saliva, semen, cerebrospinal fluid, respiratory air, urine, feces, blood, plasma, lymph. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_cerebrospinal_fluid Portion of cerebrospinal fluid Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_urine Portion of urine Excretion in liquid state processed by the kidney. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Portion_of_venous_blood Portion of venous blood Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Segment_of_neuraxis Segment of neuraxis Organ segment of neuraxis with one or more fixed fiat boundaries. Examples: brain, brainstem, spinal cord. Curation status: Imported from Foundational Model of Anatomy (FMA). FMA:Solid_organ Solid organ Organ the unshared parts of which do not surround macroscopic anatomical spaces; only its shared parts (subdivisions of hollow tree organs) contain anatomical spaces. Examples: lung, liver, thymus, ovary, muscle (organ), meninx, superficial fascia, skin. Curation status: Imported from Foundational Model of Anatomy (FMA). owl:Thing Definition source: ONSTR curators. milliequivalent per kilogram per day (mEq/kg)/d (meq/kg)/d mEq/kg/d meq/kg/d Milliequivalent per kilogram per day is a dietary nutrient intake per unit time equal to dietary nutrient (usually electrolyte or trace element) intake of 1 mEq (one milliequivalent) per 1 kg of human body mass in 1 d (day) time interval. Curation status: Incomplete Definition source: ONSTR curators kilocalorie per day C/d Cal/d kCal/d kcals/d Kilocalorie per day is a dietary energy intake per unit time equal to dietary energy intake of 1 kCal in 1 day time interval. Curation status: Incomplete Definition source: Rani H. Singh. leucine exchange unit Leu-exchange unit leucine exchange Leucine exchange unit is an amino-acid exchange unit that is 30 milligrams of the amino-acid leucine. Curation status: Incomplete Definition source: ONSTR curators. niacin equivalent per day NE/d Niacin equivalent per day is a unit vitamin per unit time that is equal to niacin (vitamin B3) intake of 1 NE in 1 day time interval. Curation status: Incomplete categorical label NPNL for non-pregnant non-lactating state datum NPNL non-pregnant non-lactating state categorical label non-pregnant non-lactating state label Curation status: Incomplete Cup as a nutrition labeling unit is defined in the United States law as 240 mL. It is commonly used as a measure of volume for both liquid and dry food items, and also as a means to estimate mass of the item being measured. Definition source: http://en.wikipedia.org/wiki/Cup_(unit) cup unit U.S. "legal" cup Cup unit is a food measurement unit that is equal to 240 mL or 16 tablespoons or 8.12 fl oz. Curation status: Incomplete Definition source: http://en.wikipedia.org/wiki/Fluid_ounce Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Fluid_ounce fluid ounce FL OZ FO fl oz foz foz us Fluid ounce is a volume unit that is a non-standard unit of volume equal to one eight (1/8) of the United States gallon or 29.57352 milliliters (or the same number of cubic centimeters (cm^3)) of the International System of Units. Curation status: Incomplete Definition source: ONSTR curators. microgram per milliliter mcg/mL mcg/ml ug/mL ug/ml μg/mL μg/ml Microgram per milliliter is a mass density unit which is equal to mass of substance of 1 microgram (1 μg) contained in the volume of 1 milliliter (1 mL). Curation status: Incomplete Definition source: ONSTR curators piece unit P pcs Piece unit is a food measurement unit that is equal to one single countable unit of food item or a portion of (part of) larger food item that is usually sliced (divided) into smaller portions in order to be ingested by humans for nutrition or pleasure purposes. Curation status: Incomplete One (piece of) candy, two (pieces of) crackers, three pieces of pizza, one piece of cake. Definition source: ONSTR curators. niacin equivalent per kilogram per day (NE/kg)/d NE/kg/d Niacin equivalent per kilogram per day is a unit vitamin per mass per unit time that is equal to niacin (vitamin B3) intake of 1 NE per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators liter per day L/d l/d Liter per day is a volume per unit time that is equal to nutrient intake of 1 L (1 dm^3) in 1 day time interval. Curation status: Incomplete 1 μg of of folic acid as a food fortificant is equal to 1.7 DFE. 1 μg of folic acid as a dietary supplement taken on an empty stomach is equal to 2 DFE. [Source: West Suitor, C., Bailey, L. B. (2000) Dietary Folate Equivalents: Interpretation and Application. Journal of the American Dietetic Association, Vol 100, Issue 1, pp. 88-94.] Definition source: West Suitor, C., Bailey, L. B. (2000) Dietary Folate Equivalents: Interpretation and Application. Journal of the American Dietetic Association, Vol 100, Issue 1, pp. 88-94. Dietary folate equivalents account for differences in the absorption of naturally occurring food folate and bioavailable synthetic folic acid. [Source: West Suitor, C., Bailey, L. B. (2000) Dietary Folate Equivalents: Interpretation and Application. Journal of the American Dietetic Association, Vol 100, Issue 1, pp. 88-94.] dietary folate equivalent unit DFE dietary folate equivalent Dietary folate equivalent unit (DFE) is a vitamin specific measurement unit equal to 1 μg of food folate or 0.6 μg of folic acid added to food, or 0.5 μg of folic acid taken as supplement on an empty stomach. Curation status: Incomplete Definition source: ONSTR curators. retinol equivalent per day RE/d Retinol equivalent per day is a unit vitamin per unit time that is equal to vitamin A (retinol) intake of 1 RE in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators. kilocalorie per kilogram per day (C/kg)/day (kCal/kg)/day C/kg/day kCal/kg/day kcals/kg/day Kilocalorie per kilogram per day is a dietary energy intake per unit time equal to dietary energy intake of 1 kCal per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators. microgram per deciliter mcg/dL mcg/dl ug/dL ug/dl μg/dL μg/dl Microgram per deciliter is a mass density unit which is equal to the mass of substance of 1 microgram (1 μg) contained in the volume of 1 deciliter (1 dl). Curation status: Incomplete Definition source: http://en.wikipedia.org/Pound_(mass) Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thsaurus.owl#Pound pound Avoirdupois pound LB international avoirdupois pound lb lb av lbm pound-mass Mass unit is a base unit that is used in the imperial, United States customary and other systems of measurement, and that is equal to 0.45359237 kilograms (kg) of the International System of Measurement or 16 ounces of the US customary system of measurements. Curation status: Incomplete Definition source: ONSTR curators. microgram per day ug/day μg/day Microgram per day is a mass per unit time that is equal to the nutrient intake of 1 μg in 1 day time interval. Curation status: Incomplete Definition source: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc.(2001) Food and Nutrition Board, Institute of Medicine, National Academy of Sciences, National Academy Press, Washington DC, pp. 770-773. Retinol activity equivalent unit for quivalent unit for preformed vitamin A (retinol) is equal to retinol equivalent unit (RE), whereas, retinol activity equivalent unit for dietary provitamin A carotenoinds is two-fold greater than retinol equivalent unit (RE). [Source: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc.(2001) Food and Nutrition Board, Institute of Medicine, National Academy of Sciences, National Academy Press, Washington DC, pp. 770-773.] retinol activity equivalent unit RAE retinol activity equivalent Retinol activity equivalent unit is a vitamin A specific unit denoting a quantity equal to 1 μg of retinol (vitamin A), or 12 μg of β-carotene, or 24 μg of α-carotene or 24 μg of β-cryptoxantin. Curation status: Incomplete Definition source: ONSTR curators. milliequivalent per day mEq/d meq/d Milliequivalent per day is a dietary nutrient intake per unit time that is equal to dietary nutrient (usually electrolyte or trace element) intake of 1 mEq (one milliequivalent) in 1 d (day) time interval. Curation status: Incomplete Definition source: ONSTR curators fluid ounce per kilogram per day FO/d floz/d foz/d Fluid ounce per kilogram per day is a volume per unit mass per unit time that is equal to nutrient intake of 1 fl oz per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: http://en.wikipedia.org/wiki/Cup_(unit) Definition source: http://purl.bioontology.org/ontology/NCIM/C1532188 tablespoon unit T TBSP tablespoonful tb tbs tbsp tbsp us tbspl tbspln Tablespoon unit is a food measurement unit that is approximately equal to the volume of 14.8 to 15 mL or 1/2 fl oz. Curation status: Incomplete categorical label P for pregnant state datum P pregnant state categorical label pregnant state label Curation status: Incomplete Definition source: ONSTR curators fluid ounce per day FO/d fl oz/d foz/d Fluid ounce per day is a volume per unit time that is equal to nutrient intake of 1 FO in 1 day time interval. Curation status: Incomplete Currently, most nutrient databases, as well as nutrition labels, do not distinguish among all the different forms of vitamin E found in food, and still use α-TE, thus including the contribution of all naturally occurring forms of vitamin E. Because the forms of vitamin E other than the naturally occurring form RRR-αtocopherol) do not occur in foods, the intake of α-TE is greater than the intake of α-tocopherol alone, and it is thus recommended that the use of α-TE be abandoned due to the lack of evidence of bioavailability via transport in the blood plasma or tissues. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) DRIs: The essential guide to nutrient requirements. Institute of medicine of the National academies. The National academies press, Washington DC, pp 236-237. ] Definition source: ONSTR curators. alpha-tocopherol equivalent per day alpha-TE/d α-TE/d Alpha-tocopherol equivalent per day is a unit vitamin per unit time that is equal to vitamin E intake of 1 α-TE in 1 day time interval. Curation status: Incomplete categorical label M for male phenotypic sex datum M male phenotypic sex label phenotypic male category label phenotypic sex M Curation status: Incomplete categorical label L for lactating state datum L lactating state categorical label lactating state label Curation status: Incomplete Definition source: ONSTR curators. dietary folate equivalent per day DFE/d Dietary folate equivalent per day is a unit vitamin per unit time that is equal to folacin (folic acid, folate, vitamin B9) intake of 1 DFE in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators. gram per day g/day Gram per day is a mass per unit time that is equal to the nutrient intake of 1 g in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators microgram per kilogram per day (ug/kg)/day (μg/kg)/day ug/kg/day μg/kg/day Microgram per kilogram per day is a mass per unit mass per unit time that is equal to the nutrient intake of 1 μg per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: The definition of an international unit is generally arbitrary and technical, and has to be officially approved by the International Conference for Unification of Formulae [Source: http://ncicb.nci.nih.gov/xml/EVS/Thesaurus.owl#International_Unit_of_Biological_Activity ] Definition source: The unitage assigned by the WHO to International Biological Standards - substances, classed as biological according to the criteria provided by WHO Expert Committee on Biological Standardization (e.g. hormones, enzymes, and vaccines), to enable the results of biological and immunological assay procedures to be expressed in the same way throughout the world. [Source: http://ncicb.nci.nih.gov/xml/EVS/Thesaurus.owl#International_Unit_of_Biological_Activity ] Definition source: http://en.wikipedia.org/wiki/International_unit Definition source: http://ncicb.nci.nih.gov/xml/EVS/Thesaurus.owl#International_Unit_of_Biological_Activity international unit IE IU UI Unit of measurement of the quantity of a substance based on its biological activity or produced effect. Curation status: Incomplete Definition source: ONSTR curators. milligram per deciliter mg/dL mg/dl Milligram per deciliter is a mass density unit which is equal to mass of substance of 1 milligram (1 mg) contained in the volume of 1 deciliter (1 dL). Curation status: Incomplete Definition source: ONSTR curators liter per kilogram per day (L/kg)/d (l/kg)/d L/kg/d l/kg/d Liter per kilogram per day is a volume per unit mass per unit time that is equal to nutrient intake of 1 L per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete categorical label AG for ambiguous genitalia phenotypic sex datum AG ambiguous genitalia phenotypic sex label phenotypic ambiguous genitalia person category label phenotypic sex AG Curation status: Incomplete Definition source: ONSTR curators. picogram per milliliter pg/mL pg/ml Picogram per mililiter is a mass density unit which is equal to mass of substance of 1 picogram (1 pg) contained in the volume of 1 milliliter (1 mL). Curation status: Incomplete Definition source: http://en.wikipedia.org/wiki/Food_energy Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesausrus.owl#Kilocalorie One kilocalorie is used as a (non-standard) food energy unit that measures of the energy-producing potential of food as a unit of potential energy contained by a substance, which can be liberated when the material is oxidized. It is a measure of the amount of energy 1000 times greater than the units in scientific contexts known also as calories, or gram calories (cal). Food calories are thereby referred to less ambiguously in some formal contexts as kilocalories (kcal) or kilogram calories. One food calorie is equal to 4.184 kilojoules. [Source: http://en.wikipedia.org/wiki/Food_energy] kilocalorie C Calorie Calorie (nutrition) Kcal [Cal] food calorie kcals kilogram calorie kilogram-calorie nutrition calorie Kilocalorie is a food energy unit that is a non-SI unit of energy defined as the amount of heat required to raise the temperature of one kilogram of pure water by one degree Centigrade (Celsius) under standard conditions (i.e. the specific heat of the water at 15 degrees Celsius and the constant pressure of 101.325 kPa or one atm being defined as unity). Curation status: Incomplete Definition source: http://ncicb.nci.gov/xml/owl/EVS/Thesaurus.owl#Scoopful_Dosing_Unit scoop unit measurment scoop scoopful Scoop unit is a derived unit that is equal to the manufacturer specified quantity of nutritional item, drug or active ingredient. Curation status: Incomplete Definition source: http://en.wikipedia.org/wiki/Teaspoon For nutritional labeling in the U.S., the teaspoon is defined as having volume of precisely 5 mL. [Source: http://en.wikipedia.org/wiki/Teaspoon] teaspoon unit TS TSP teaspoonful Teaspoon unit is a food measurement unit that is approximately equal to the volume of 4.8 to 5 mL or 1/3 fl oz. Curation status: Incomplete Currently, most nutrient databases, as well as nutrition labels, do not distinguish among all the different forms of vitamin E found in food, and still use α-TE, thus including the contribution of all naturally occurring forms of vitamin E. Because the forms of vitamin E other than the naturally occurring form RRR-αtocopherol) do not occur in foods, the intake of α-TE is greater than the intake of α-tocopherol alone, and it is thus recommended that the use of α-TE be abandoned due to the lack of evidence of bioavailability via transport in the blood plasma or tissues. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) DRIs: The essential guide to nutrient requirements. Institute of medicine of the National academies. The National academies press, Washington DC, pp 236-237. ] Definition source: ONSTR curators. alpha-tocopherol equivalent per kilogram per day (alpha-TE/kg)/d (α-TE/kg)/d alhpa-TE/kg/d α-TE/kg/d Alpha-tocopherol equivalent per kilogram per day is a unit vitamin per mass per unit time that is equal to vitamin E intake of 1 α-TE per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators. international unit per day IE/d IU/d UI/d International unit per day is a dietary nutrient intake per unit time equal to the dietary nutrient (usually vitamin) intake of 1 IU in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators gram per kilogram per day (g/kg)/day g/kg/day Gram per kilogram per day is a mass per unit mass per unit time that is equal to the nutrient intake of 1 g per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators. Definition source: http://en.wikipedia.org/wiki/Equivalent_(chemistry) This definition is not all that good. Need to formulate a better one, from a better source. equivalent unit Eq eq equivalent molar equivalent Equivalent is a derived unit that is a unit of the amount of substance which reacts with or supply one mole of hydrogen ions (H+) or which reacts with or supply one mole of electrons in a redox reaction. Curation status: Incomplete Definition source: ONSTR curators. milliequivalent mEq meq Milliequivalent is a derived unit (unit of substance) equal to one thousandth of an equivalent unit. Curation status: Incomplete Definition source: ONSTR curators. retinol activity equivalent per kilogram per day (RAE/kg)/d RAE/kg/d Retinol activity equal per kilogram per day is a unit vitamin per mass per unit time that is equal to vitamin A (retinol) intake of 1 RAE per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: Singh, R., Lesperance, E., Crawford, K. (2001) PKU food list. Keeping track of the foods you eat. Emory University, Department of Human Genetics, Division of Medical Genetics, pp.3. phenylalanine exchange unit Phe-exchange unit phenylalanine exchange Phenylalanine exchange unit is an amino-acid exchange unit that is equal to 15 milligrams of the amino-acid L-phenylalanine. Curation status: Incomplete Definition source: ONSTR curators. milligram per day mg/day Milligram per day is a mass per unit time that is equal to the nutrient intake of 1 mg in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators. This class will most likely be replaced by the parallel UO class if/when team UO asserts one. cells per microliter cells per uL cells per μL cells/μL Cells per microliter is a cell concentration unit that is equal to one cell in a volume of 1 microliter. Curation status: Incomplete categorical label F for female phenotypic sex datum F female phenotypic sex label phenotypic female category label phenotypic sex F Curation status: Incomplete Currently, most nutrient databases, as well as nutrition labels, do not distinguish among all the different forms of vitamin E found in food, and still use α-TE, thus including the contribution of all naturally occurring forms of vitamin E. Because the forms of vitamin E other than the naturally occurring form RRR-αtocopherol) do not occur in foods, the intake of α-TE is greater than the intake of α-tocopherol alone, and it is thus recommended that the use of α-TE be abandoned due to the lack of evidence of bioavailability via transport in the blood plasma or tissues. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) DRIs: The essential guide to nutrient requirements. Institute of medicine of the National academies. The National academies press, Washington DC, pp 236-237. ] Definition source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) DRIs: The essential guide to nutrient requirements. Institute of medicine of the National academies. The National academies press, Washington DC, pp 237. Definition source: http://ncc.umn.edu/products/databaseNUTvitamins.html Three DRI values for vitamin E (the EAR, RDA and AI) apply only to intake of 2R-stereoizomeric forms of α-tocopherol from food, fortified foods and supplements. The other naturally occuring isomers of vitamin E (β-, γ- and δ-tocopherols and α-, β-, γ- and δ-tocotrienols) do not contribute to meeting the vitamin E requirements, because they are not converted to α-tocopherol in humans. [Source: Otten, J. J., Pitzi Hellwig, J., Meyers, L. D. Eds (2006) DRIs: The essential guide to nutrient requirements. Institute of medicine of the National academies. The National academies press, Washington DC., pp 237. ] alpha-tocopherol equivalent unit alpha-TE alpha-tocoferol equivalent α-TE Alpha-tocopherol equivalent unit is a vitamin specific measurement unit that is determined based on biological activity of α-, β-, γ- and δ-tocopherols and that can be calculated following the formula: 1 α-TE = 1 mg α-RRR-tocopherol + (0.4 mg β-tocopherol) + (0.1 mg γ-tocopherol) + (0.01 mg δ-tocopherol) + 1 mg of all-rac-;-tocopherols (i.e all synthetic forms of tocopherol). Curation status: Incomplete Definition source: ONSTR curators. retinol equivalent per kilogram per day (RE/kg)/d RE/kg/d Retinol equivalent per kilogram per day is a unit vitamin per mass per unit time that is equal to vitamin A (retinol) intake of 1 RE per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: http://dietbio.com/vegaterisme/en/vit_a.html retinol equivalent unit RE retinol equivalent Retinol equivalent unit is a derived unit that is equal to 1 μg of retinol (vitamin A), or 6 μg of β-carotene, or equal to 3.333 International Units of vitamin A. Curation status: Incomplete Definition source: ONSTR curators milligram per kilogram per day (mg/kg)/day mg/kg/day Milligram per kilogram per day is a mass per unit mass per unit time that is equal to the nutrient intake of 1 mg per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: http://en.wikipedia.org/wiki/Ounce#International_avoirdupois_ounce Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Ounce ounce Avoirdupois ounce OZ international avoirdupois ounce international ounce oz oz avdp Ounce is a mass unit that is a unit of mass used in the imperial and United States customary system of measurement units and that is equal to one sixteenth of avoirdupois pound or 28.3945 grams of the International system of units (SI). Curation status: Incomplete Definition source: ONSTR curators. dietary folate equivalent per kilogram per day (DFE/kg)/d DFE/kg/d Dietary folate equivalent per kilogram per day is a unit vitamin per mass per unit time that is equivalent to folacin (folic acid, folate, vitamin B9) intake of 1 DFE per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: http://en.wikipedia.org/Inch Definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thsaurus.owl#Inch inch " in international inch Inch is a length unit that is used in the imperial, United States customary and other systems of measurement, and that is equal to 24.5 millimeters (mm) of the International System of Measurement or 1/36 of a yard, or 1/12 of a foot in of the US customary system of measurements. Curation status: Incomplete Definition source: ONSTR curators. nanogram per milliliter ng/mL ng/ml Nanogram per mililiter is a mass density unit which is equal to mass of substance of 1 nanogram (1 ng) contained in the volume of 1 milliliter (1 mL). Curation status: Incomplete Definition source: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc.(2001) Food and Nutrition Board, Institute of Medicine, National Academy of Sciences, National Academy Press, Washington DC, pp. 770-773. niacin equivalent unit NE niacin equivalent Niacin equivalent unit is a vitamin specific measurement unit equal to 1 mg of niacin (vitamin B3) or equal to 60 mg of amino-acid tryptophan. Curation status: Incomplete Definition source: ONSTR curators. international unit per kilogram per day (IE/kg)/d (IU/kg)/d (UI/kg)/d IE/kg/d IU/kg/d UI/kg/d International unit per kilogram per day is a dietary nutrient intake per unit time equal to the dietary nutrient (usually vitamin) intake of 1 IU per 1 kg of human body mass in 1 day time interval. Curation status: Incomplete Definition source: ONSTR curators. retinol activity equivalent per day RAE/d RAE/day Retinol activity equivalent per day is a unit vitamin per unit time that is equal to vitamin A (retinol) intake of 1 RAE in 1 day time interval. Curation status: Incomplete meter m A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second. Curation status: Imported from the Unit Ontology (UO) kilogram kg A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Sèvres, France. Curation status: Imported from the Unit Ontology (UO) centimeter cm A length unit which is equal to one hundredth of a meter or 10^[-2] m. Curation status: Imported from the Unit Ontology (UO) gram g A mass unit which is equal to one thousandth of a kilogram or 10^[-3] kg. Curation status: Imported from the Unit Ontology (UO) milligram mg A mass unit which is equal to one thousandth of a gram or 10^[-3] g. Curation status: Imported from the Unit Ontology (UO) microgram ug μg A mass unit which is equal to one millionth of a gram or 10^[-6] g. Curation status: Imported from the Unit Ontology (UO) nanogram ng A mass unit which is equal to 10^[-12] g. Curation status: Imported from the Unit Ontology (UO) degree celsius C ° C A temperature derived unit which is equal to one Kelvin degree. However, they have their zeros at different points. The Centigrade scale has its zero at 273.15 K. Curation status: Imported from the Unit Ontology (UO) minute min A time unit which is equal to 60 seconds. Curation status: Imported from the Unit Ontology (UO) hour h A time unit which is equal to 3600 seconds or 60 minutes. Curation status: Imported from the Unit Ontology (UO) day A time unit which is equal to 24 hours. Curation status: Imported from the Unit Ontology (UO) week A time unit which is equal to 7 days. Curation status: Imported from the Unit Ontology (UO) 01/29/2012 SN: The lenght of the month of 30 days refrred in the UO, is the approximation of what is in science called " a synodic month", which is the average period of the Moon's revolution around the Earth (i.e. informally, a time interval between the two successive new moons). Average time interval (length) of a synodic month is 29.530788 days. Synodic month is used as a basis ofr most calendars. month A time unit which is approximately equal to the length of time of one of cycle of the moon's phases which is science is taken to be equal to 30 days. Curation status: Imported from the Unit Ontology (UO) year a annus y yr A time unit which is equal to 12 months which is science is taken to be equal to 365.25 days. Curation status: Imported from the Unit Ontology (UO) micromolar micromole per liter uM μM μmol/L A derived concentration unit which is a standard measure of the number of moles of a given substance per liter of solution. Curation status: Imported from the Unit Ontology (UO) kilogram per square meter BMI unit body mass index unit kg/m^[2] An area density unit which is equal to the mass of an object in kilograms divided by the surface area in meters squared. Curation status: Imported from the Unit Ontology (UO) milliliter mL ml A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter. Curation status: Imported from the Unit Ontology (UO) liter L l A volume unit which is equal to one thousandth of a cubic meter or 10^[-3] m^[3], or to 1 cubic decimeter. Curation status: Imported from the Unit Ontology (UO) microliter uL ul μL μl A volume unit which is equal to one millionth of a liter or 10^[-6] L. Curation status: Imported from the Unit Ontology (UO) joule J An energy unit which is equal to the energy required when a force of 1 newton moves an object 1 meter in the direction of the force. Curation status: Imported from the Unit Ontology (UO) degree fahrenheit F ° F A temperature derived unit which is equal to 5/9ths of a kelvin. Negative 40 degrees Fahrenheit is equal to negative 40 degrees Celsius. Curation status: Imported from the Unit Ontology (UO) pH A dimensionless concentration notation which denotes the acidity of a solution in terms of activity of hydrogen ions (H+). Curation status: Imported from the Unit Ontology (UO) cells per milliliter cells per ml A unit of cell concentration which is equal to one cell in a volume of 1 milliliter. Curation status: Imported from the Unit Ontology (UO) gram per deciliter g/dL g/dl A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters. Curation status: Imported from the Unit Ontology (UO) deciliter dL dl A volume unit which is equal to one tenth of a liter or 10^[-1] L. Curation status: Imported from the Unit Ontology (UO) 0.4 Akshaye Dhawan Prabhu Shankar Rajshekar Sunderraman Rani Singh Sham Navathe Sivaram Arabandi Snežana Nikolić 2014-09-03 Ontology for Newborn Screening Follow-up and Translational Research (ONSTR) is an application ontology covering data items, processes and agents involved in practices of newborn screening, short- and long-term follow-up of patients with inheritable and congenital disorders and related translational research. RDF/XML Keywords: biomedical ontology, neborn screening, inherited metabolic disorders, translational research, metabolism, genetic disorders, health care, public health, nutrition, diet. Ontology for Newborn Screening Follow-up and Translational Research As of ONSTR v0.4 (this version), active ontology development has been discontinued. For more information about this ontology please contact ONSTR/NBSDC project PI Dr. Rani Singh (rsingh@emory.edu) or Snezana Nikolic (snez.sn@gmail.com). For release notes please see http://onstr.googlecode.com/svn/tags/currentRelease/2014-09-03/ ONSTR v0.4 is based on the SVN checkout r641. 0.4 ONSTR BFO 2 Reference: BFO does not claim to provide complete coverage of entities of all types. It seeks only to provide coverage of those entities studied by empirical science together with those entities which affect or are involved in human activities such as data processing and planning - coverage that is sufficiently broad to provide assistance to those engaged in building domain ontologies for purposes of data annotation. BFO 2 Reference: BFO's treatment of continuants and occurrents - as also its treatment of regions, rests on a dichotomy between space and time, and on the view that there are two perspectives on reality - earlier called the 'SNAP' and 'SPAN' perspectives, both of which are essential to the non-reductionist representation of reality as we understand it from the best available science. BFO 2 Reference: For both terms and relational expressions in BFO, we distinguish between primitive and defined. 'Entity' is an example of a primitive term. Primitive terms in a highest-level ontology such as BFO are terms that are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms. Alan Ruttenberg Albert Goldfain Barry Smith Bill Duncan Bjoern Peters Chris Mungall David Osumi-Sutherland Fabian Neuhaus Holger Stenzhorn James A. Overton Janna Hastings Jie Zheng Jonathan Bona Larry Hunter Leonard Jacuzzo Ludger Jansen Mark Ressler Mathias Brochhausen Mauricio Almeida Melanie Courtot Pierre Grenon Randall Dipert Ron Rudnicki Selja Seppälä Stefan Schulz Thomas Bittner Werner Ceusters Yongqun "Oliver" He Please see the project site https://github.com/BFO-ontology/BFO, the bfo2 owl discussion group http://groups.google.com/group/bfo-owl-devel, the bfo2 discussion group http://groups.google.com/group/bfo-devel, the tracking google doc http://goo.gl/IlrEE, and the current version of the bfo2 reference http://purl.obolibrary.org/obo/bfo/dev/bfo2-reference.docx. This ontology is generated from a specification at https://github.com/BFO-ontology/BFO/tree/master/src/ontology/owl-group/specification/ and with the code that generates the OWL version in https://github.com/BFO-ontology/BFO/tree/master/src/tools/. A very early version of BFO version 2 in CLIF is at http://purl.obolibrary.org/obo/bfo/dev/bfo.clif. The BSD license on the BFO project site refers to code used to build BFO. This BFO 2.0 version represents a major update to BFO and is not strictly backwards compatible with BFO 1.1. The previous OWL version of BFO, version 1.1.1 will remain available at http://ifomis.org/bfo/1.1 and will no longer be updated. The BFO 2.0 OWL is a classes-only specification. The incorporation of core relations has been held over for a later version.