Erica Marcos Jiangan Xie Yongqun "Oliver" He (YH) 04-11-2016 OVAE is a biomedical ontology in the area of vaccine adverse events. OVAE is an extension of the community-based Ontology of Adverse Events (OAE). OWL-DL A biomedical ontology in the area of vaccine adverse events. OVAE: Ontology of Vaccine Adverse Events Vision Release: 1.0.34 BFO OWL specification label Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. Really of interest to developers only BFO OWL specification label BFO OWL specification label BFO CLIF specification label Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 Person:Alan Ruttenberg Really of interest to developers only BFO CLIF specification label BFO CLIF specification label editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> editor preferred label editor preferred term editor preferred term editor preferred term~editor preferred label example example of usage A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> example of usage example of usage has curation status PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot OBI_0000281 has curation status has curation status definition definition textual definition The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition definition textual definition editor note An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. PERSON:Daniel Schober GROUP:OBI:<http://purl.obfoundry.org/obo/obi> IAO:0000116 uberon editor_note 1 editor_note editor note editor note definition editor term editor Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition editor definition editor term editor term editor alternative term An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> alternative term alternative term definition source formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 PERSON:Daniel Schober Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition source definition source curator note An administrative note of use for a curator but of no use for a user PERSON:Alan Ruttenberg IAO:0000232 uberon curator_notes 1 curator_notes curator note curator note curator notes imported from For external terms/classes, the ontology from which the term was imported PERSON:Alan Ruttenberg PERSON:Melanie Courtot GROUP:OBI:<http://purl.obolibrary.org/obo/obi> imported from imported from expand expression to expand assertion to elucidation person:Alan Ruttenberg Person:Barry Smith Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms elucidation elucidation has associated axiom(nl) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom associated with a term expressed using natural language has associated axiom(nl) has associated axiom(nl) has associated axiom(fol) Person:Alan Ruttenberg Person:Alan Ruttenberg An axiom expressed in first order logic using CLIF syntax has associated axiom(fol) has associated axiom(fol) YH, JX a chinese translation represents a chinese translation of the existing term. Chinese translation The AE 'cough AE' has the 'label of AE outcome' of 'cough'; 'infection AE' has the 'label of AE outcom' of 'infection'. an annotation property that represents the label of an adverse event Yongqun Oliver He, Jiangan Hardy Xie label of adverse event outcome adverse event outcome The NCBITaxon ontology ID of an organism. Oliver He, Yue Liu organism NCBITaxon ID An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context. temporal interpretation https://code.google.com/p/obo-relations/wiki/ROAndTime https://github.com/oborel/obo-relations/wiki/ROAndTime tooth SubClassOf 'never in taxon' value 'Aves' x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL. Chris Mungall ?X DisjointWith RO_0002162 some ?Y never in taxon An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon. taxonomic class assertion S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T. RO:0002174 uberon dubious_for_taxon 1 1 dubious_for_taxon this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost dubious_for_taxon S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S RO:0002175 applicable for taxon uberon present_in_taxon 1 1 present_in_taxon present_in_taxon An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL. logical macro assertion https://github.com/oborel/obo-relations/wiki/ShortcutRelations A logical macro assertion whose domain is an IRI for a class The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL logical macro assertion on a class A logical macro assertion whose domain is an IRI for a property logical macro assertion on a property logical macro assertion on an object property logical macro assertion on an annotation property relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q' Chris Mungall is direct form of An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class. UBPROP:0000001 uberon external_definition 1 external_definition This annotation property may be replaced with an annotation property from an external ontology such as IAO external_definition A textual description of an axiom loss in this ontology compared to an external ontology. UBPROP:0000002 uberon axiom_lost_from_external_ontology 1 axiom_lost_from_external_ontology This annotation property may be replaced with an annotation property from an external ontology such as IAO axiom_lost_from_external_ontology Notes on the homology status of this class. UBPROP:0000003 uberon homology_notes 1 homology_notes This annotation property may be replaced with an annotation property from an external ontology such as IAO homology_notes An alternate comment for a class taken unmodified from an external source. Note that obo format only allows a single comment for a class, and does not provide a structured means of adding provenance info. UBPROP:0000005 uberon external_comment 1 external_comment This annotation property may be replaced with an annotation property from an external ontology such as IAO external_comment UBPROP:0000006 uberon implements_design_pattern 1 implements_design_pattern implements_design_pattern Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. UBPROP:0000007 uberon has_relational_adjective 1 has_relational_adjective has_relational_adjective Notes on the how instances of this class vary across species. UBPROP:0000008 uberon taxon_notes 1 taxon_notes taxon_notes Notes on the evolved function of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000009 uberon function_notes 1 function_notes function_notes Notes on the structure, composition or histology of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000010 uberon structure_notes 1 structure_notes structure_notes Notes on the ontogenic development of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000011 uberon development_notes 1 development_notes development_notes Notes on how similar or equivalent classes are represented in other ontologies. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000012 uberon external_ontology_notes 1 external_ontology_notes external_ontology_notes Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000013 uberon terminology_notes 1 terminology_notes terminology_notes UBPROP:0000100 uberon is_count_of 1 is_count_of is count of A property used in conjunction with repeated_element_number to indicate an axis and directionality along that axis. If P preceding_element_is R, and P is_count_of S, and X P N, and X' P N+1, then it follows that every X R some X', and the class expression [S and R some X' and inv(R) some X] is empty (i.e. X is followed by X', with no intermediates) UBPROP:0000101 uberon preceding_element_is 1 preceding_element_is preceding element is x phalanx_number N if and only if (i) x is a phalanx, and (ii) x is phalanx number N in a series of phalanges repeated along an prixomo-distal axis, with phalanx_number 1 being the proximalmost phalanx. Note that in humans, the distalmost phalanx has phlanax_number 3, except in ray_number 1, where the distalmost has phalanx_number 2 UBPROP:0000105 uberon phalanx_number 1 phalanx_number Most land mammals including humans have a 2-3-3-3-3 formula in both the hands (or paws) and feet. Primitive reptiles typically had the formula 2-3-4-4-5, and this pattern, with some modification, remained in many later reptiles and in the mammal-like reptiles. The phalangeal formula in the flippers of cetaceans (marine mammals) is 2-12-8-1 phalanx number A metadata relation between a class and its taxonomic rank (eg species, family) ncbi_taxonomy has_rank eco subset CUMBO developmental_classification A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes. EFO slim derived from the union of EHDAA2 and EMAPA - still to be checked functional_classification Subset consisting of classes creating for grouping purposes A grouping class that depends on an assumption of homology between subclasses classes that have some inconsistency with FMA somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord, peripheral nerves, kidneys, ureters, bladder, urethra, gonads abstract class brought in to group ontology classes but not informative organs, excluding individual muscles and skeletal elements Phenotype slim Uberon slim - subset that excludes obscure terms and deep compositional terms abstract upper-level terms not directly useful for analysis core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO uberon dc-contributor 1 dc-contributor contributor creator Source Source subset_property has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_namespace has_related_synonym in_subset shorthand label uberon foaf-depicted_by 1 foaf-depicted_by depicted_by is part of my brain is part of my body (continuant parthood, two material entities) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime part_of BFO:0000050 uberon part_of part_of part of part of http://www.obofoundry.org/ro/#OBO_REL:part_of inheres-in_at inheresInAt b inheres_in c at t =Def. b is a dependent continuant & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [051-002]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'inheres in at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'inheres in@en(x,y,t)'. BFO 2 Reference: Inherence is a subrelation of s-depends_on which holds between a dependent continuant and an independent continuant that is not a spatial region. Since dependent continuants cannot migrate from one independent continuant bearer to another, it follows that if b s-depends_on independent continuant c at some time, then b s-depends_on c at all times at which a exists. Inherence is in this sense redundantly time-indexed.For example, consider the particular instance of openness inhering in my mouth at t as I prepare to take a bite out of a donut, followed by a closedness at t+1 when I bite the donut and start chewing. The openness instance is then shortlived, and to say that it s-depends_on my mouth at all times at which this openness exists, means: at all times during this short life. Every time you make a fist, you make a new (instance of the universal) fist. (Every time your hand has the fist-shaped quality, there is created a new instance of the universal fist-shaped quality.) BFO2 Reference: independent continuant that is not a spatial region BFO2 Reference: specifically dependent continuant (iff (inheresInAt a b t) (and (DependentContinuant a) (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))) // axiom label in BFO2 CLIF: [051-002] inheres in at all times realizes this disease course realizes this disease this investigation realizes this investigator role this shattering realizes this fragility to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realizes site of [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant contains process s-depends-on_at specificallyDependsOn A pain s-depends_on the organism that is experiencing the pain a gait s-depends_on the walking object. (All at some specific time.) a shape s-depends_on the shaped object one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs reciprocal s-dependence between occurrents: a process of buying and the associated process of selling reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball the one-sided dependence of an occurrent on an independent continuant: handwave on a hand the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45 the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45 the two-sided reciprocal s-dependence of the roles of husband and wife [20 Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'specifically depends on at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'specifically depends on@en(x,y,t)'. BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28 BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20 BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place. BFO2 Reference: specifically dependent continuant\; process; process boundary To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64 If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001]) If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001]) If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002]) an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002]) if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002]) (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002] (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002] (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001] (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002] (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001] specifically depends on at all times o-has-part hasOccurrentPart [copied from inverse property 'part of occurrent'] Mary’s 5th birthday occurrent_part_of Mary’s life [copied from inverse property 'part of occurrent'] The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football. [copied from inverse property 'part of occurrent'] the first set of the tennis match occurrent_part_of the tennis match. b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) [copied from inverse property 'part of occurrent'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. [copied from inverse property 'part of occurrent'] BFO2 Reference: occurrent [copied from inverse property 'part of occurrent'] b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002]) (iff (hasOccurrentPart a b) (occurrentPartOf b a)) // axiom label in BFO2 CLIF: [007-001] has occurrent part o-has-ppart hasProperOccurrentPart [copied from inverse property 'proper part of occurrent'] b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001]) b has_proper_occurrent_part c = Def. c proper_occurrent_part_of b. [XXX-001 has proper occurrent part r-location-of_st [copied from inverse property 'occupies spatial region at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'occupies spatial region at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'occupies spatial region@en'(x,y,t) [copied from inverse property 'occupies spatial region at some time'] BFO2 Reference: independent continuant [copied from inverse property 'occupies spatial region at some time'] BFO2 Reference: spatial region [copied from inverse property 'occupies spatial region at some time'] b occupies_spatial_region r at t means that r is a spatial region in which independent continuant b is exactly located (axiom label in BFO2 Reference: [041-002]) has spatial occupant at some time occupied-by [copied from inverse property 'occupies spatiotemporal region'] BFO 2 Reference: The occupies_spatiotemporal_region and occupies_temporal_region relations are the counterpart, on the occurrent side, of the relation occupies_spatial_region. [copied from inverse property 'occupies spatiotemporal region'] p occupies_spatiotemporal_region s. This is a primitive relation between an occurrent p and the spatiotemporal region s which is its spatiotemporal extent. (axiom label in BFO2 Reference: [082-003]) has spatiotemporal occupant occupies occupiesSpatiotemporalRegion BFO 2 Reference: The occupies_spatiotemporal_region and occupies_temporal_region relations are the counterpart, on the occurrent side, of the relation occupies_spatial_region. p occupies_spatiotemporal_region s. This is a primitive relation between an occurrent p and the spatiotemporal region s which is its spatiotemporal extent. (axiom label in BFO2 Reference: [082-003]) occupies spatiotemporal region o-part-of occurrentPartOf Mary’s 5th birthday occurrent_part_of Mary’s life The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football. the first set of the tennis match occurrent_part_of the tennis match. [copied from inverse property 'has occurrent part'] b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. BFO2 Reference: occurrent b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002]) occurrent_part_of is antisymmetric. (axiom label in BFO2 Reference: [123-001]) occurrent_part_of is reflexive (every occurrent entity is an occurrent_part_of itself). (axiom label in BFO2 Reference: [113-002]) occurrent_part_of is transitive. (axiom label in BFO2 Reference: [112-001]) occurrent_part_of satisfies unique product. (axiom label in BFO2 Reference: [125-001]) occurrent_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [124-001]) (forall (x y t) (if (and (occurrentPartOf x y t) (not (= x y))) (exists (z) (and (occurrentPartOf z y t) (not (exists (w) (and (occurrentPartOf w x t) (occurrentPartOf w z t)))))))) // axiom label in BFO2 CLIF: [124-001] (forall (x y t) (if (and (occurrentPartOf x y t) (occurrentPartOf y x t)) (= x y))) // axiom label in BFO2 CLIF: [123-001] (forall (x y t) (if (exists (v) (and (occurrentPartOf v x t) (occurrentPartOf v y t))) (exists (z) (forall (u w) (iff (iff (occurrentPartOf w u t) (and (occurrentPartOf w x t) (occurrentPartOf w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [125-001] (forall (x y z) (if (and (occurrentPartOf x y) (occurrentPartOf y z)) (occurrentPartOf x z))) // axiom label in BFO2 CLIF: [112-001] (forall (x) (if (Occurrent x) (occurrentPartOf x x))) // axiom label in BFO2 CLIF: [113-002] part of occurrent t-part-of temporalPartOf the 4th year of your life is a temporal part of your life\. The first quarter of a game of football is a temporal part of the whole game\. The process of your heart beating from 4pm to 5pm today is a temporal part of the entire process of your heart beating.\ The 4th year of your life is a temporal part of your life the process boundary which separates the 3rd and 4th years of your life. your heart beating from 4pm to 5pm today is a temporal part of the process of your heart beating b proper_temporal_part_of c =Def. b temporal_part_of c & not (b = c). (axiom label in BFO2 Reference: [116-001]) b temporal_part_of c =Def.b occurrent_part_of c & & for some temporal region t, b occupies_temporal_region t & for all occurrents d, t (if d occupies_temporal_region t & t? occurrent_part_of t then (d occurrent_part_of a iff d occurrent_part_of b)). (axiom label in BFO2 Reference: [078-003]) if b proper_temporal_part_of c, then there is some d which is a proper_temporal_part_of c and which shares no parts with b. (axiom label in BFO2 Reference: [117-002]) (forall (x y) (if (properTemporalPartOf x y) (exists (z) (and (properTemporalPartOf z y) (not (exists (w) (and (temporalPartOf w x) (temporalPartOf w z)))))))) // axiom label in BFO2 CLIF: [117-002] (iff (properTemporalPartOf a b) (and (temporalPartOf a b) (not (= a b)))) // axiom label in BFO2 CLIF: [116-001] (iff (temporalPartOf a b) (and (occurrentPartOf a b) (exists (t) (and (TemporalRegion t) (occupiesSpatioTemporalRegion a t))) (forall (c t_1) (if (and (Occurrent c) (occupiesSpatioTemporalRegion c t_1) (occurrentPartOf t_1 r)) (iff (occurrentPartOf c a) (occurrentPartOf c b)))))) // axiom label in BFO2 CLIF: [078-003] temporal part of s-projection-of-st_st spatial projection of spatiotemporal at some time t-projection-of-st temporal projection of spatiotemporal spans occupiesTemporalRegion p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001]) occupies temporal region span-of spanOf [copied from inverse property 'occupies temporal region'] p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001]) has temporal occupant during-which-exists [copied from inverse property 'exists at'] BFO2 Reference: entity [copied from inverse property 'exists at'] BFO2 Reference: temporal region [copied from inverse property 'exists at'] b exists_at t means: b is an entity which exists at some temporal region t. (axiom label in BFO2 Reference: [118-002]) during which exists c-part-of_st continuantPartOfAt Mary’s arm continuant_part_of Mary in the time of her life prior to her operation the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. [copied from inverse property 'has continuant part at some time'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'part of continuant@en'(x,y,t) BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. BFO2 Reference: continuant BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. [copied from inverse property 'has continuant part at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has continuant part@en'(x,y,t) b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) continuant_part_of is antisymmetric. (axiom label in BFO2 Reference: [120-001]) continuant_part_of is reflexive (every continuant entity is a continuant_part_of itself). (axiom label in BFO2 Reference: [111-002]) continuant_part_of is transitive. (axiom label in BFO2 Reference: [110-001]) continuant_part_of satisfies unique product. (axiom label in BFO2 Reference: [122-001]) continuant_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [121-001]) if b continuant_part_of c at t and b is an independent continuant, then b is located_in c at t. (axiom label in BFO2 Reference: [047-002]) (forall (x t) (if (Continuant x) (continuantPartOfAt x x t))) // axiom label in BFO2 CLIF: [111-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (IndependentContinuant x)) (locatedInAt x y t))) // axiom label in BFO2 CLIF: [047-002] (forall (x y t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y x t)) (= x y))) // axiom label in BFO2 CLIF: [120-001] (forall (x y t) (if (and (continuantPartOfAt x y t) (not (= x y))) (exists (z) (and (continuantPartOfAt z y t) (not (exists (w) (and (continuantPartOfAt w x t) (continuantPartOfAt w z t)))))))) // axiom label in BFO2 CLIF: [121-001] (forall (x y t) (if (exists (v) (and (continuantPartOfAt v x t) (continuantPartOfAt v y t))) (exists (z) (forall (u w) (iff (iff (continuantPartOfAt w u t) (and (continuantPartOfAt w x t) (continuantPartOfAt w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [122-001] (forall (x y z t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y z t)) (continuantPartOfAt x z t))) // axiom label in BFO2 CLIF: [110-001] (iff (ImmaterialEntity a) (and (IndependentContinuant a) (not (exists (b t) (and (MaterialEntity b) (continuantPartOfAt b a t)))))) // axiom label in BFO2 CLIF: [028-001] part of continuant at some time c-has-part_st hasContinuantPartAt [copied from inverse property 'part of continuant at some time'] Mary’s arm continuant_part_of Mary in the time of her life prior to her operation [copied from inverse property 'part of continuant at some time'] the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has continuant part@en'(x,y,t) [copied from inverse property 'part of continuant at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'part of continuant@en'(x,y,t) [copied from inverse property 'part of continuant at some time'] BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) [copied from inverse property 'part of continuant at some time'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. [copied from inverse property 'part of continuant at some time'] BFO2 Reference: continuant [copied from inverse property 'part of continuant at some time'] BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. [copied from inverse property 'part of continuant at some time'] b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) (iff (hasContinuantPartAt a b t) (continuantPartOfAt b a t)) // axiom label in BFO2 CLIF: [006-001] has continuant part at some time c-part-of-object_at [copied from inverse property 'has continuant part at all times'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) forall(t) exists_at(y,t) -> exists_at(x,t) and 'part of continuant'(x,y,t) This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'has continuant part at all times' [copied from inverse property 'has continuant part at all times'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has continuant part at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has continuant part@en(x,y,t)'. part of continuant at all times that whole exists c-has-part-object_at [copied from inverse property 'part of continuant at all times'] Mary’s arm continuant_part_of Mary in the time of her life prior to her operation [copied from inverse property 'part of continuant at all times'] the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists. forall(t) exists_at(y,t) -> exists_at(x,t) and 'has continuant part'(x,y,t) This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'part of continuant at all times' [copied from inverse property 'part of continuant at all times'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'part of continuant at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'part of continuant@en(x,y,t)'. [copied from inverse property 'part of continuant at all times'] BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001]) [copied from inverse property 'part of continuant at all times'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion. [copied from inverse property 'part of continuant at all times'] BFO2 Reference: continuant [copied from inverse property 'part of continuant at all times'] BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region. [copied from inverse property 'part of continuant at all times'] b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001]) has continuant part at all times that part exists X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. BSPO:0000124 uberon in_proximal_side_of in_proximal_side_of in_proximal_side_of X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. BSPO:0000125 uberon in_distal_side_of in_distal_side_of in_distal_side_of a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in. Yongqun He adverse event occurs in is_manufactured_by http://www.affymetrix.com/products/arrays/specific/hgu133.affx is_manufactered_by http://www.affymetrix.com/ (if we decide to use these URIs for the actual entities) c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this. Alan Ruttenberg Liju Fan has_make has_manufacturer is_manufactured_by is_specified_output_of A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. Alan Ruttenberg PERSON:Bjoern Peters is_specified_output_of an vaccine adverse event 'occurs in population' human vaccinee population is equivalent to say: 'occurs in' human vaccinee 'part of' human vaccine population. an 'occurs in' relation that is a shortcut relation combining the 'occurs in' relation in an specific term which is part of a population. Yongqun He occurs in population participates in this blood clot participates in this blood coagulation this input material (or this output material) participates in this process this investigator participates in this investigation a relation between a continuant and a process, in which the continuant is somehow involved in the process participates_in participates in A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant). An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process). A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant. concretizes this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. has_function has function David Osumi-Sutherland <= Primitive instance level timing relation between events before or simultaneous with Relation between occurrents, shares start and end boundaries. David Osumi-Sutherland RO:0002082 coincides_with is_equal_to uberon simultaneous_with simultaneous_with t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2) simultaneous with simultaneous_with David Osumi-Sutherland X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) ends after David Osumi-Sutherland ends_at_start_of meets X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) immediately precedes David Osumi-Sutherland io X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y)) starts during David Osumi-Sutherland d during X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y)) happens during David Osumi-Sutherland o overlaps X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). ends during x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) overlaps RO:0002158 uberon homologous_to homologous_to homologous_to RO:0002202 uberon develops_from develops_from develops_from RO:0002203 uberon develops_into develops_into develops_into Chris Mungall Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends. https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. temporally related to RO:0002258 uberon developmentally_preceded_by developmentally_preceded_by developmentally preceded by A mereological relationship or a topological relationship Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships mereotopologically related to RO:0002507 uberon has_material_contribution_from has_material_contribution_from has material contribution from is_distributed_by is a relation that specifies a company that distributes a product (e.g., vaccine). The company is very likely not the manufacturer of the product. YH, ZX is_distributed_by X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides. uberon in_central_side_of in_central_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern . uberon transitively_anteriorly_connected_to transitively anteriorly connected to uberon transitively_connected_to transitively_connected to . uberon transitively_distally_connected_to transitively distally connected to . uberon transitively_proximally_connected_to transitively proximally connected to a data property that indicates a vaccinee having an occurrence of a specific VAE of a particular data value that is in the range of 0 and 1. Yongqun He has VAE occurrence Yongqun He a data property that represents the age with the unit of year. has age in year BFO:0000001 entity Entity entity Julius Caesar Verdi’s Requiem the Second World War your body mass index BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) entity entity BFO:0000002 continuant Continuant continuant An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] continuant continuant BFO:0000003 occurrent Occurrent occurrent An entity that has temporal parts and that happens, unfolds or develops through time. BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] occurrent BFO:0000004 ic IndependentContinuant independent continuant a chair a heart a leg a molecule a spatial region an atom an orchestra. an organism the bottom right portion of a human torso the interior of your mouth A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] independent continuant BFO:0000005 A continuant that is either dependent on one or other independent continuant bearers or inheres in or is borne by other entities. dependent continuant true true BFO:0000006 s-region SpatialRegion BFO 2 Reference: Spatial regions do not participate in processes. Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional. A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001]) All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001]) (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] spatial region true true BFO:0000008 t-region TemporalRegion Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] temporal region true true BFO:0000011 st-region SpatiotemporalRegion the spatiotemporal region occupied by a human life the spatiotemporal region occupied by a process of cellular meiosis. the spatiotemporal region occupied by the development of a cancer tumor A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001]) All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001]) Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001]) Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001]) Every spatiotemporal region occupies_spatiotemporal_region itself. Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002]) (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] spatiotemporal region BFO:0000015 process Process process a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping the course of a disease the flight of a bird the life of an organism your process of aging. An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] process BFO:0000016 disposition Disposition an atom of element X has the disposition to decay to an atom of element Y certain people have a predisposition to colon cancer children are innately disposed to categorize objects in certain ways. the cell wall is disposed to filter chemicals in endocitosis and exocitosis the cell wall is disposed to filter chemicals in endocytosis and exocytosis BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type [89 BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type. b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] disposition BFO:0000017 realizable RealizableEntity realizable entity the disposition of this piece of metal to conduct electricity. the disposition of your blood to coagulate the function of your reproductive organs the role of being a doctor the role of this boundary to delineate where Utah and Colorado meet A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] realizable entity BFO:0000019 quality Quality the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] quality BFO:0000020 sdc SpecificallyDependentContinuant specifically dependent continuant Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key of one-sided specifically dependent continuants: the mass of this tomato of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates. the disposition of this fish to decay the function of this heart: to pump blood the mutual dependence of proton donors and acceptors in chemical reactions [79 the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction the pink color of a medium rare piece of grilled filet mignon at its center the role of being a doctor the shape of this hole. the smell of this portion of mozzarella A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i &lt; j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004]) b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] specifically dependent continuant BFO:0000023 role Role role John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] role BFO:0000028 3d-s-region ThreeDimensionalSpatialRegion a cube-shaped region of space a sphere-shaped region of space, A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001]) (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] three-dimensional spatial region BFO:0000029 site Site Manhattan Canyon) a hole in the interior of a portion of cheese a rabbit hole an air traffic control region defined in the airspace above an airport the Grand Canyon the Piazza San Marco the cockpit of an aircraft the hold of a ship the interior of a kangaroo pouch the interior of the trunk of your car the interior of your bedroom the interior of your office the interior of your refrigerator the lumen of your gut your left nostril (a fiat part – the opening – of your left nasal cavity) b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] site BFO:0000031 gdc GenericallyDependentContinuant generically dependent continuant The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. the pdf file on your laptop, the pdf file that is a copy thereof on my laptop the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] generically dependent continuant BFO:0000034 function Function the function of a hammer to drive in nails the function of a heart pacemaker to regulate the beating of a heart through electricity the function of amylase in saliva to break down starch into sugar BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc. A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] function BFO:0000035 p-boundary ProcessBoundary the boundary between the 2nd and 3rd year of your life. p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001]) Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002]) (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002] (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001] process boundary BFO:0000040 material MaterialEntity material entity a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic the undetached arm of a human being An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] material entity BFO:0000141 immaterial ImmaterialEntity BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10 immaterial entity BFO:0000148 0d-t-region ZeroDimensionalTemporalRegion a temporal region that is occupied by a process boundary right now the moment at which a child is born the moment at which a finger is detached in an industrial accident the moment of death. temporal instant. A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] zero-dimensional temporal region CARO:0001008 gross anatomical part Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. gross anatomical part The simplest aldehyde. CHEBI:14274 CHEBI:24077 CHEBI:337763 CHEBI:5142 Beilstein:1209228 ChEMBL:7381846 ChemIDplus:50-00-0 CiteXplore:110589 CiteXplore:11094105 CiteXplore:11688455 CiteXplore:12101431 CiteXplore:12429629 CiteXplore:12686735 CiteXplore:15091529 CiteXplore:15189269 CiteXplore:15450713 CiteXplore:15810952 CiteXplore:15893897 CiteXplore:15914300 CiteXplore:15975255 CiteXplore:16001656 CiteXplore:16136465 CiteXplore:16149025 CiteXplore:16280667 CiteXplore:16423181 CiteXplore:16481239 CiteXplore:16551731 CiteXplore:17618393 CiteXplore:18837732 CiteXplore:2432751 CiteXplore:25042713 CiteXplore:7548723 CiteXplore:7689168 CiteXplore:7896413 CiteXplore:8204010 CiteXplore:8747965 CiteXplore:9048644 CiteXplore:9686972 DrugBank:DB03843 Gmelin:445 HMDB:HMDB01426 KEGG COMPOUND:50-00-0 KEGG COMPOUND:C00067 KEGG DRUG:D00017 MetaCyc:FORMALDEHYDE NIST Chemistry WebBook:50-00-0 PDBeChem:FLH PDBeChem:FOR Reaxys:1209228 UM-BBD:c0122 Wikipedia:Formaldehyde FORMALDEHYDE Formaldehyde formaldehyde chebi_ontology Aldeide formica CH2O Chlodithan Chlodithane FORMALIN Fannoform Formaldehyd Formalin Formalina Formaline Formalith Formic aldehyde Formol InChI=1S/CH2O/c1-2/h1H2 Methaldehyde Methanal Methylene glycol Methylene oxide Oxomethane Oxomethylene Paraform WSFSSNUMVMOOMR-UHFFFAOYSA-N [H]C([H])=O CHEBI:16842 formaldehyde CHEBI:16842 A disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form. CHEBI:10296 CHEBI:10380 CHEBI:14497 CHEBI:22460 CHEBI:22760 CHEBI:25005 CHEBI:27755 CHEBI:613009 Beilstein:1292745 ChEMBL:19053747 ChemIDplus:63-42-3 CiteXplore:1292745 CiteXplore:17329833 CiteXplore:18300214 CiteXplore:19846069 CiteXplore:19913595 CiteXplore:20094999 CiteXplore:20503067 CiteXplore:20699559 CiteXplore:20873837 CiteXplore:20961532 CiteXplore:21403918 CiteXplore:2432147 CiteXplore:2456994 CiteXplore:6194884 CiteXplore:7574700 Gmelin:882872 KEGG COMPOUND:63-42-3 KEGG COMPOUND:C00243 KEGG DRUG:D00046 KEGG GLYCAN:G10504 KNApSAcK:C00001136 NIST Chemistry WebBook:63-42-3 Reaxys:1292745 beta-D-galactopyranosyl-(1->4)-D-glucopyranose lactose chebi_ontology (+)-lactose (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-oxane-3,4,5-triol (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran-3,4,5-triol (2R,3S,4S,5R,6S)-2-methylol-6-[(2R,3R,4S,5R,6S)-4,5,6-trihydroxy-2-methylol-tetrahydropyran-3-yl]oxy-tetrahydropyran-3,4,5-triol (Gal)1 (Glc)1 1-beta-D-Galactopyranosyl-4-D-glucopyranose 4-(beta-D-galactosido)-D-glucose 4-O-beta-D-galactopyranosyl-D-glucose C12H22O11 D-lactose GUBGYTABKSRVRQ-QKKXKWKRSA-N Galbeta1-4-Glc InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 Lac Laktobiose Laktose Milchzucker Milk sugar OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)OC(O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O beta-D-Gal-(1->4)-D-Glc beta-D-Galp-(1->4)-D-Glcp beta-Gal1,4-Glc lactobiose milk sugar CHEBI:17716 lactose CHEBI:17716 Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. molecular entity chebi_ontology . entidad molecular entidades moleculares entite moleculaire molecular entities molekulare Entitaet CHEBI:23367 molecular entity CHEBI:23367 A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. chemical entity chebi_ontology . grouped_by_chemistry CHEBI:24431 chemical entity CHEBI:24431 CHEBI:15093 CHEBI:26724 CHEBI:26726 CHEBI:33795 CHEBI:33796 CHEBI:9201 Beilstein:1721909 Gmelin:83165 Wikipedia:Sorbitol glucitol chebi_ontology C6H14O6 Sorbitol gulitol rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol sorbitol sorbitols CHEBI:30911 glucitol CHEBI:30911 A (1->6)-alpha-D-glucan which has extra branching consisting of (1->2), (1->3) or (1->4) linkages. ChemIDplus:9004-54-0 CiteXplore:8154046 KEGG COMPOUND:9004-54-0 KEGG COMPOUND:C00372 KEGG DRUG:D00060 KEGG DRUG:D06541 KEGG GLYCAN:G10502 chebi_ontology (1,6-alpha-D-Glucosyl)m (1,6-alpha-D-Glucosyl)m+1 (1,6-alpha-D-Glucosyl)n (1,6-alpha-D-Glucosyl)n+1 1,6-alpha-D-Glucan Dextran 40 Dextran 70 Dextran 75 dextran dextrane dextrano dextrans dextranum CHEBI:52071 dextran CHEBI:52071 A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (Streptomyces fradiae) and used medically especially to treat local infections. DrugBank:DB00994 KEGG COMPOUND:1404-04-2 KEGG COMPOUND:C00384 KEGG DRUG:D08260 Neomycin chebi_ontology C22H41N5O13R2.C12H26N4O6 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2[*])[C@H](N)[C@@H](O)[C@@H]1O CHEBI:7507 neomycin CHEBI:7507 IAO:0000005 objective specification In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction. a directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved. 2009-03-16: original definition when imported from OBI read: "objective is an non realizable information entity which can serve as that proper part of a plan towards which the realization of the plan is directed." 2014-03-31: In the example of usage ("In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction") there is a protocol which is the ChIP assay protocol. In addition to being concretized on paper, the protocol can be concretized as a realizable entity, such as a plan that inheres in a person. The objective specification is the part that says that some protein and DNA interactions are identified. This is a specification of a process endpoint: the boundary in the process before which they are not identified and after which they are. During the realization of the plan, the goal is to get to the point of having the interactions, and participants in the realization of the plan try to do that. Answers the question, why did you do this experiment? PERSON: Alan Ruttenberg PERSON: Barry Smith PERSON: Bjoern Peters PERSON: Jennifer Fostel goal specification OBI Plan and Planned Process/Roles Branch OBI_0000217 objective specification IAO:0000030 information content entity Examples of information content entites include journal articles, data, graphical layouts, and graphs. A generically dependent continuant that is about some thing. 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ). PERSON: Chris Stoeckert OBI_0000142 information content entity IAO:0000033 directive information entity An information content entity whose concretizations indicate to their bearer how to realize them in a process. 2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was "is the specification of a process that can be concretized and realized by an actor" with alternative term "instruction".It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term. 2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it. 8/6/2009 Alan Ruttenberg: Changed label from "information entity about a realizable" after discussions at ICBO Werner pushed back on calling it realizable information entity as it isn't realizable. However this name isn't right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn't about the plan, it, once concretized, *is* the plan. -Alan PERSON: Alan Ruttenberg PERSON: Bjoern Peters directive information entity NCBITaxon:10239 GC_ID:1 ncbi_taxonomy Vira Viridae viruses Viruses NCBITaxon:10240 GC_ID:1 ncbi_taxonomy Poxviridae NCBITaxon:10241 GC_ID:1 ncbi_taxonomy Chordopoxvirinae NCBITaxon:10255 NCBITaxon:12871 GC_ID:1 small pox virus smallpox smallpox virus ncbi_taxonomy variola virus VAR Variola virus NCBITaxon:102793 GC_ID:1 ncbi_taxonomy H5N1 H5N1 subtype NCBITaxon:10292 GC_ID:1 ncbi_taxonomy Herpesviridae NCBITaxon:10293 GC_ID:1 ncbi_taxonomy Alphaherpesvirinae NCBITaxon:10319 GC_ID:1 ncbi_taxonomy Varicellovirus NCBITaxon:10335 HHV-3 VZV GC_ID:1 Varicella-zoster virus ncbi_taxonomy Human alphaherpesvirus 3 Varicella Zoster Virus varicella zoster virus VZV varicella-zoster virus VZV Human herpesvirus 3 NCBITaxon:10407 HBV GC_ID:1 ncbi_taxonomy Human hepatitis B virus hepatitis B virus (HBV) hepatitis B virus HBV hepatitis B virus, HBV human hepatitis B virus HBV Hepatitis B virus NCBITaxon:10508 GC_ID:1 ncbi_taxonomy Adenoviridae NCBITaxon:10566 GC_ID:1 ncbi_taxonomy Human Papilloma Virus human papillomavirus HPV Human papillomavirus NCBITaxon:10880 GC_ID:1 ncbi_taxonomy Reoviridae NCBITaxon:10912 GC_ID:1 ncbi_taxonomy Rotaviruses Rotavirus NCBITaxon:11018 GC_ID:1 ncbi_taxonomy Togaviridae NCBITaxon:11041 GC_ID:1 ncbi_taxonomy Rubella virus NCBITaxon:11050 GC_ID:1 ncbi_taxonomy Flavivirus (arbovirus group B) Flaviviridae NCBITaxon:11051 GC_ID:1 arboviruses group B ncbi_taxonomy Flavivirus NCBITaxon:11071 GC_ID:1 ncbi_taxonomy Japanese encephalitis viruses Japanese encephalitis virus group NCBITaxon:11072 GC_ID:1 ncbi_taxonomy Japanese encephalitis Japanese encephalitis (JE) virus Japanese encephalitis virus JE Japanese encephalitis virus JEV Japanese encephalitis virus NCBITaxon:11089 YFV GC_ID:1 ncbi_taxonomy Flavivirus febricis yellow fever virus YFV Yellow fever virus NCBITaxon:11157 GC_ID:1 negative-sense genome single-stranded RNA viruses ncbi_taxonomy Mononegavirales NCBITaxon:11158 GC_ID:1 ncbi_taxonomy Paramyxoviridae NCBITaxon:11159 GC_ID:1 ncbi_taxonomy Paramyxovirinae NCBITaxon:11161 GC_ID:1 ncbi_taxonomy Mumps virus NCBITaxon:11229 GC_ID:1 ncbi_taxonomy Morbilliviruses Morbillivirus NCBITaxon:11234 NCBITaxon:11230 GC_ID:1 ncbi_taxonomy Cell-associated subacute sclerosing panencephalitis Subacute sclerosing panencephalitis virus measles virus MV rougeole virus rubeola virus subacute sclerose panencephalitis virus subacute sclerosing panencephalitis virus, SSPEV Measles virus NCBITaxon:11270 GC_ID:1 PMID:16186241 ncbi_taxonomy Rhabdoviridae NCBITaxon:11292 GC_ID:1 ncbi_taxonomy Rabies virus NCBITaxon:11308 GC_ID:1 ncbi_taxonomy Orthomyxoviridae NCBITaxon:11320 FLUAV GC_ID:1 ncbi_taxonomy Influenza virus type A influenza A virus INF A Influenza A virus NCBITaxon:117571 NCBITaxon:40673 GC_ID:1 bony vertebrates ncbi_taxonomy Euteleostomi NCBITaxon:12058 GC_ID:1 ncbi_taxonomy Picormavirus Picornavirus Picornaviridae NCBITaxon:12080 HPV-1 PV1 GC_ID:1 ncbi_taxonomy Human poliovirus type 1 Poliovirus type 1 poliovirus type 1 PV1 Human poliovirus 1 NCBITaxon:12083 HPV-2 GC_ID:1 ncbi_taxonomy Human Poliovirus type 2 Poliovirus type 2 Human poliovirus 2 NCBITaxon:12086 HPV-3 GC_ID:1 ncbi_taxonomy Human poliovirus type 3 Poliovirus type 3 poliovirus type 3 P3 Human poliovirus 3 NCBITaxon:12092 GC_ID:1 ncbi_taxonomy Hepatitis A virus NCBITaxon:1224 GC_ID:11 PMID:11321122 PMID:11542017 PMID:11837318 PMID:16280474 purple bacteria purple bacteria and relatives purple non-sulfur bacteria purple photosynthetic bacteria purple photosynthetic bacteria and relatives ncbi_taxonomy proteobacteria Proteobacteria NCBITaxon:1236 GC_ID:11 PMID:16280474 ncbi_taxonomy Gammaproteobacteria Garrity et al. 2005 Proteobacteria gamma subdivision Purple bacteria, gamma subdivision g-proteobacteria gamma proteobacteria gamma subdivision gamma subgroup Gammaproteobacteria NCBITaxon:1239 NCBITaxon:31968 GC_ID:11 PMID:10555317 PMID:11034484 PMID:11542017 PMID:15143038 Gram-positive bacteria low G+C Gram-positive bacteria low GC Gram+ ncbi_taxonomy Bacillus/Clostridium group Clostridium group firmicutes Firmacutes Gram positive bacteria Low G+C firmicutes clostridial firmicutes firmicutes Firmicutes NCBITaxon:1301 GC_ID:11 PMID:10555340 PMID:14657115 PMID:1720654 PMID:7537076 PMID:8995803 ncbi_taxonomy Streptococcus NCBITaxon:1313 GC_ID:11 ncbi_taxonomy Diplococcus pneumoniae Micrococcus pneumoniae Streptococcus pneumoniae NCBITaxon:1385 GC_ID:11 ncbi_taxonomy Bacillus/Staphylococcus group Bacillales NCBITaxon:138950 NCBITaxon:138953 GC_ID:1 ncbi_taxonomy Poliovirus Human enterovirus C NCBITaxon:1392 GC_ID:11 PMID:8123566 anthrax anthrax bacterium ncbi_taxonomy Bacillus cereus var. anthracis Bacteridium anthracis Bacillus anthracis NCBITaxon:1485 GC_ID:11 ncbi_taxonomy Clostridium NCBITaxon:1513 GC_ID:11 ncbi_taxonomy Bacillus tetani Clostridium tetani NCBITaxon:151340 GC_ID:1 PMID:20206957 Papillomavirus ncbi_taxonomy Papillomaviridae NCBITaxon:1717 GC_ID:11 PMID:7729671 ncbi_taxonomy Bacillus diphtheriae Bacterium diphtheriae Microsporon diphthericum Microsporon diphtheriticum Mycobacterium diphtheriae Pacinia loeffleri Corynebacterium diphtheriae NCBITaxon:197911 GC_ID:1 ncbi_taxonomy Influenzavirus A NCBITaxon:197912 GC_ID:1 ncbi_taxonomy Influenzavirus B NCBITaxon:2 GC_ID:11 PMID:10425795 PMID:10425796 PMID:10425797 PMID:10490293 PMID:10843050 PMID:10939651 PMID:10939673 PMID:10939677 PMID:11211268 PMID:11321083 PMID:11321113 PMID:11411719 PMID:11540071 PMID:11542017 PMID:11542087 PMID:11760965 PMID:12054223 PMID:2112744 PMID:270744 PMID:8123559 PMID:8590690 PMID:9103655 PMID:9336922 eubacteria ncbi_taxonomy Monera Procaryotae Prokaryota Prokaryotae bacteria not Bacteria Haeckel 1894 prokaryote prokaryotes Bacteria NCBITaxon:2759 GC_ID:1 PMID:23020233 eucaryotes eukaryotes ncbi_taxonomy Eucarya Eucaryotae Eukarya Eukaryotae eukaryotes Eukaryota NCBITaxon:28216 GC_ID:11 ncbi_taxonomy 'Betaproteobacteria' Proteobacteria beta subdivision Purple bacteria, beta subdivision b-proteobacteria beta proteobacteria beta subdivision beta subgroup Betaproteobacteria NCBITaxon:314146 GC_ID:1 PMID:11214319 PMID:12082125 PMID:12878460 PMID:15522813 ncbi_taxonomy Euarchontoglires NCBITaxon:314293 GC_ID:1 ncbi_taxonomy Anthropoidea Simiiformes NCBITaxon:32524 GC_ID:1 amniotes ncbi_taxonomy Amniota NCBITaxon:33154 GC_ID:1 ncbi_taxonomy Fungi/Metazoa group opisthokonts Opisthokonta NCBITaxon:33213 GC_ID:1 ncbi_taxonomy Bilateria NCBITaxon:333774 GC_ID:1 ncbi_taxonomy unclassified Papillomaviridae NCBITaxon:35237 GC_ID:1 ncbi_taxonomy dsDNA viruses, no RNA stage NCBITaxon:35268 GC_ID:1 ncbi_taxonomy Retroid viruses Retro-transcribing viruses NCBITaxon:35278 GC_ID:1 ncbi_taxonomy ssRNA positive-strand viruses, no DNA stage NCBITaxon:35301 GC_ID:1 ncbi_taxonomy ssRNA negative-strand viruses NCBITaxon:35325 GC_ID:1 ncbi_taxonomy dsRNA nonenveloped viruses dsRNA viruses NCBITaxon:40674 GC_ID:1 mammals ncbi_taxonomy mammals Mammalia NCBITaxon:439488 GC_ID:1 ncbi_taxonomy ssRNA viruses NCBITaxon:487 GC_ID:11 ncbi_taxonomy Diplokokkus intracellularis meningitidis Micrococcus intracellularis Micrococcus meningitidis Micrococcus meningitidis cerebrospinalis Neisseria meningitidis. Neisseria weichselbaumii Neisseria meningitidis NCBITaxon:517 GC_ID:11 PMID:11491321 ncbi_taxonomy Bordetella Moreno-Lopez 1952 (Approved Lists 1980) emend. Von Wintzingerode et al. 2001 Bordetella NCBITaxon:520 GC_ID:11 PMID:8240949 ncbi_taxonomy Bacterium tussis-convulsivae Haemophilus pertussis Hemophilus pertussis Microbe de la coqueluche Bordetella pertussis NCBITaxon:543 GC_ID:11 PMID:10555323 PMID:10555334 PMID:16166704 ncbi_taxonomy Enterobacteraceae Enterobacteraceae (ex Lapage 1979) Lapage 1982, fam. nov., nom. rev. Enterobacteriaceae (ex Rahn 1937) Ewing et al. 1980, fam. nov., nom. rev. Enterobacteriaceae Rahn 1937 gamma-3 proteobacteria Enterobacteriaceae NCBITaxon:560210 GC_ID:1 ncbi_taxonomy Dintheria NCBITaxon:590 GC_ID:11 PMID:10319519 PMID:10939679 PMID:12072558 PMID:15653929 PMID:15653930 PMID:3231714 PMID:9731304 ncbi_taxonomy Samonella Salmonella NCBITaxon:59201 NCBITaxon:149049 GC_ID:11 PMID:15653929 PMID:15653930 PMID:7149525 ncbi_taxonomy Salmonella cholerae-suis subsp. cholerae-suis Salmonella choleraesuis subsp. choleraesuis Salmonella enterica I Salmonella enterica subsp. I Salmonella enterica subsp. enterica NCBITaxon:689832 GC_ID:1 ncbi_taxonomy Sedoreovirinae NCBITaxon:712 GC_ID:11 PMID:10843050 PMID:15280320 PMID:15388716 PMID:17220461 PMID:2223605 ncbi_taxonomy Pasteurellaceae Pohl 1981 Pasteurellaceae NCBITaxon:724 GC_ID:11 PMID:1736960 ncbi_taxonomy Haemophilus Winslow et al. 1917 Haemophilus NCBITaxon:727 GC_ID:11 ncbi_taxonomy Bacterium influenzae Coccobacillus pfeifferi Haemophilus meningitidis Influenza-bacillus Mycobacterium influenzae Haemophilus influenzae NCBITaxon:80840 GC_ID:11 ncbi_taxonomy 'Burkholderiales' Burkholderia/Oxalobacter/Ralstonia group Burkholderiales NCBITaxon:85007 NCBITaxon:1761 GC_ID:11 PMID:11837321 PMID:1736962 PMID:19244447 ncbi_taxonomy Corynebacterineae NCBITaxon:89593 GC_ID:1 Craniata ncbi_taxonomy Craniata <chordata> NCBITaxon:90370 NCBITaxon:41530 NCBITaxon:601 NCBITaxon:72667 GC_ID:11 PMID:10319519 PMID:10758910 PMID:15653930 PMID:16558776 PMID:9336938 ncbi_taxonomy Bacillus typhi Bacterium (subgen. Eberthella) typhi Salmonella choleraesuis serovar Typhi Salmonella choleraesuis typhi Salmonella enterica ser. typhi Salmonella enterica serotype Typhi Salmonella enterica serovar Typhi Salmonella typhi Salmonella enterica subsp. enterica serovar Typhi NCBITaxon:91061 GC_ID:11 PMID:20212322 ncbi_taxonomy Bacillus/Lactobacillus/Streptococcus group Firmibacteria Bacilli NCBITaxon:9347 GC_ID:1 eutherian mammals placental mammals placentals ncbi_taxonomy Placentalia placentals Eutheria NCBITaxon:9606 GC_ID:1 human man ncbi_taxonomy Homo sapiens OAE:0000001 a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'. YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device. YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention. YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events. YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'. Yongqun He AE adverse reaction WEB: http://en.wikipedia.org/wiki/Adverse_event WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068 The OAE official website is: http://www.oae-ontology.org/. adverse event OAE:0000002 medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury. YH WEB: http://wiki.answers.com/Q/What_is_medical_intervention medical intervention OAE:0000004 an adverse event that occurs after a vaccination. YH vaccine adverse event OAE:0000027 an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue. YH, RR, JX musculoskeletal and connective tissue disorder AE WEB: http://www.cdc.gov/niosh/programs/msd/ A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture musculoskeletal or connective tissue AE CTCAE: E13872 MedDRA: 10028395 OAE:0000034 a behavior and neurological AE that has an outcome of fatigue, which is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities. SS, YH lethargy AE WEB: http://en.wikipedia.org/wiki/Fatigue_%28medical%29 fatigue AE CTCAE: E11098 HPO: HP_0003388 MedDRA: 10016256 (fatigue); MedDRA: 10024264 (lethargy) NCIt: C3036 SIDER: C0015672 OAE:0000055 A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment. Yongqun He, Sirarat Sarntivijai, Mathias Brochhausen, William Hogan, ‎Philip E. Empey http://en.wikipedia.org/wiki/Contraindication contraindication OAE:0000077 a planned process that is specifically a test conducted in a clinical laboratory. Rebecca Racz, Yongqun He medical laboratory test WEB: http://labmed.ascpjournals.org/content/40/2/105.full clinical laboratory test OAE:0000084 a cardiovascular disorder AE that has a cardiac disorder outcome. SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/heart+disease Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23091623 cardiac disorder AE HPO: HP_0001627 MedDRA (PT): 10061024 MedDRA (SOC) : 10007541 SIDER: C0018799 OAE:0000199 an adverse event that occurs in hair, skin, or nail. hair, skin, and nail AE YH, SS, JX hair, skin or nail AE OAE:0000200 a hair, skin, and nail AE that occurs in hair. YH, SS hair AE OAE:0000201 a hair, skin, and nail AE that occurs in nail. YH, SS nail AE OAE:0000215 a crying abnormal AE that has an outcome of abnormal inconsolable crying in a patient YH inconsolable crying AE MedDRA: 10065283 OAE:0000216 a crying abnormal AE that has an outcome of abnormal unusual high-pitched crying in a patient YH unusual high-pitched crying AE OAE:0000217 a crying abnormal AE that has an outcome of abnormal prolonged crying in a patient YH prolonged crying AE OAE:0000226 an adverse event that occurs in the site of a medical intervention (e.g., vaccination injection site). YH application site reaction medical intervention site AE MedDRA: 10003055 OAE:0000227 a site that is used for a medical intervention YH medical intervention site OAE:0000306 convulsion AE is a muscle adverse event that results in a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body SS, YH WEB: http://en.wikipedia.org/wiki/Convulsion convulsion AE HPO: HP_0001250 MedDRA ID: 10010904 SIDER: C0009951 OAE:0000323 injection-site induration AE is an skin AE that results in hardening or thickening of tissue at the physical injection site SS, YH WEB: http://wordnetweb.princeton.edu/perl/webwn?s=induration injection-site induration AE OAE:0000324 injection-site pruritus AE is an pruritus AE that results in an unpleasant sensation that evokes the desire or reflex to scratch at the physical area of injection SS, YH WEB: http://en.wikipedia.org/wiki/Itch WEB: http://medical-dictionary.thefreedictionary.com/pruritus injection-site pruritus AE MedDRA: 10022093 OAE:0000325 injection-site rash AE is a rash AE that results in a change of the skin which affects its color, appearance or texture at the physical injection site SS, YH WEB: http://en.wikipedia.org/wiki/Rash injection-site rash AE OAE:0000326 injection-site warmth AE is a homeostasis AE that results in feeling of warmth at the physical injection site SS, YH injection-site warmth AE OAE:0000327 A joint disorder AE that has an outcome of joint swelling, which is a joint disorder that results in a buildup of fluid in the soft tissue surrounding the joint SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003262.htm joint swelling AE HPO: HP_0005833 MedDRA ID: 10023232 SIDER: C0152031 OAE:0000331 A lymphadenopathy AE that results in swollen/enlarged lymph nodes SS, YH WEB: http://en.wikipedia.org/wiki/Lymphadenopathy lymphadenitis AE HPO: HP_0002840 SIDER: C0024205 OAE:0000333 a muscle AE that has an outcome of muscular weakness AE (i.e., lack of muscle strength). SS, YH WEB: http://en.wikipedia.org/wiki/Muscular_weakness muscular weakness AE HPO: HP_0001324 MedDRA ID: 10028372 SIDER: C0151786 OAE:0000334 a sensory capability AE that has an outcome of a sensation of stiffness in muscles and skeleton SS, YH musculoskeletal stiffness AE HPO: HP_0003552 MedDRA ID: 10052904 SIDER: C0948525 OAE:0000335 nasal congestion AE is a respiratory system AE that results in a blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels SS, YH WEB: http://en.wikipedia.org/wiki/Nasal_congestion nasal congestion AE HPO: HP_0001742 MedDRA: 10028735 SIDER: C0027424 OAE:0000336 a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system SS, YH common cold AE WEB: http://en.wikipedia.org/wiki/Nasopharyngitis nasopharyngitis AE HPO: HP_0002087 SIDER: C0027441 OAE:0000340 an ear disorder AE which has an outcome of otitis media that results in inflammation of the middle ear, or middle ear infection SS, YH WEB: http://en.wikipedia.org/wiki/Otitis_media otitis media AE CTCAE: E11477 HPO: HP_0008623 NCIt: C34885 SIDER: C0029882 OAE:0000343 pharyngitis AE is a digestive system AE that results in an inflammation of the throat or pharynx SS, YH WEB: http://en.wikipedia.org/wiki/Pharyngitis pharyngitis AE CTCAE: E11525 HPO: HP_0100776 MedDRA ID: 10034835 NCIt: C26851 SIDER: C0031350 OAE:0000344 a pain AE that shows a pain in sinus and throat SS, YH, MW WEB: http://www.wordinfo.info/words/index/info/view_unit/1631/ pharyngolaryngeal pain AE HPO: HP_0010833 MedDRA: 10034844 SIDER: C0858635 OAE:0000350 rhinitis AE is a respiratory system inflammation characterized by runny nose,irritation and inflammation of some internal areas of the nose SS, YH runny nose WEB: http://en.wikipedia.org/wiki/Rhinitis WEB: http://medical-dictionary.thefreedictionary.com/rhinitis rhinitis AE HPO: HP_0002257 MedDRA: 10028116 SIDER: C0035455 OAE:0000351 rhinorrhoea AE is a respiratory system AE that results in runny nose, an unusually significant amount of nasal fluid SS, YH rhinorrhoea AE WEB: http://en.wikipedia.org/wiki/Rhinorrhoea rhinorrhea AE OAE:0000358 an infection AE is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx SS, YH URI, URTI WEB: http://en.wikipedia.org/wiki/Upper_respiratory_tract_infection upper respiratory tract infection AE CTCAE: E11604 HPO: HP_0002788 NCIt: C35650 SIDER: C0041912 OAE:0000361 an abnormal body temperature AE which has an outcome of fever YH, SS body temperature increased AE febrile response pyrexia AE Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828. WEB: http://en.wikipedia.org/wiki/Pyrexia Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1-2 °F). fever AE CTCAE: E11102 MedDRA: 10005911 MedDRA: 10037660 NCIt: C3038 OAE:0000362 a skin AE that shows the symptom of rash, i.e., an abnormal change in skin color, appearance, or texture. A rash may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. YH URL: http://en.wikipedia.org/wiki/Rash URL: http://www.webmd.com/skin-problems-and-treatments/guide/common-rashes Wick JY. Drug-induced rash: nuisance or threat? Consult Pharm. 2013 Mar;28(3):160-6. PMID: 23462025. Drug-induced rash is the most commonly reported drug reaction. rash AE HPO: HP_0000988 MedDRA: 10037844 SIDER: C0015230 OAE:0000363 an adverse event that has an outcome of a pathogen infection, i.e., an infection caused by a pathogen such as a virus, bacterium, or parasite. change of name from 'infection adverse event' to 'infectious adverse event' on 09/23/13 for a better clinical relevance, move 'infection adverse event' as an alternative term - SS YH, JX infectious adverse event WEB: http://medical-dictionary.thefreedictionary.com/infection infection infection AE MedDRA: 10021789 OAE:0000364 An AE that has an outcome of syndrome. Syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others. YH syndrome AE OAE:0000366 injection-site AE is an AE that occurs in an injection site (e.g., during vaccination). YH, JX, SS injection site AE injection-site adverse event injection-site reaction local reaction AE injection-site AE CTCAE: E11138 MDR: 10022095 NCIt: C3508 OAE:0000368 an edema AE which occurs at the injection site. In this case, a collection of fluid at the injection site is found. YH, RR injection-site oedema AE injection-site swelling AE WEB: http://www.uptodate.com/contents/edema-swelling-beyond-the-basics injection-site edema AE MedDRA: 10053425 OAE:0000369 a pain AE that occurs in an injection site of a medical intervention YH injection-site pain AE MedDRA: 10022086 OAE:0000372 an injection-site AE that display an injection-site mass YH, SS injection site nodule AE injection-site mass is a mass at physical injection site injection-site mass AE OAE:0000373 a skin adverse event that has an outcome of pruritus YH, SS, MW itch itching pruritus generalised AE WEB: http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=DetailsSearch&term=pruritus+generalised&log$=activity Pruritus is an itch (Latin: pruritus), i.e., an unpleasant sensation that evokes the desire or reflex to scratch. pruritus AE CTCAE:E13686 HPO: HP_0000989 MedDRA:10037087 NCIt:C3344 SIDER: C0033774 OAE:0000374 a sensory capability AE that has an outcome of pain in a patient YH pain AE CTCAE: E11167 HPO: HP_0010833 NCIt: C3303 SIDER: C0030193 OAE:0000375 a pain AE that has outcome of myalgia. Myalgia means "muscle pain" and is a symptom of many diseases and disorders. YH, MW muscle pain AE myalgia AE CTCAE:E12485 HPO: HP_0003326 MedDRA:10028411 NCIt:C27009 SIDER: C0231528 OAE:0000376 Urticaria AE is a rash AE notable for dark red, raised, itchy bumps. YH, MW hives urticaria AE CTCAE:E13746 HPO: HP_0001025 MedDRA:10046735 NCIt:C3432 SIDER: C0042109 OAE:0000377 a pain AE that has an outcome of headache YH, MW headache AE HPO: HP_0002315 MedDRA: 10019211 SIDER: C0018681 OAE:0000378 an AE that occurs in respiratory system. I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He YH respiratory system AE OAE:0000381 a cardiovascular disorder AE that has an outcome of abnormal blood pressure, representing altered tension of the blood within the systemic arteries abnormal blood pressure AE MP: MP_0000230 OAE:0000382 a muscle adverse event which has an outcome of asthenia, which is a medical term denoting symptoms of physical weakness and loss of strength. YH asthenia AE HPO: HP_0001324 MedDRA ID: 10003549 SIDER: C0004093 OAE:0000383 a muscle pain AE that has an outcome of muscle ache. YH muscle ache AE OAE:0000385 An joint disorder AE that has an outcome of arthralgia. Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. YH, MW arthralgia AE CTCAE:E12374 HPO: HP_0002829 MedDRA:10003239 NCIt:C50464 SIDER: C0003862 OAE:0000388 a sensory capability AE that has an outcome of dizziness YH, SS, MW Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs. dizziness AE CTCAE:E12631 HPO: HP_0002321 MedDRA ID: 10013573 NCIt:C37943 SIDER: C0012833 OAE:0000390 a sensory capability AE that has an outcome of malaise YH Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise. malaise AE CTCAE: E11152 HPO: HP_0002321 MDR: 10025482 NCIt: C3832 SIDER: C0231218 OAE:0000391 a behavior and neurological AE that has an outcome of somnolence YH, SS, MW drowsiness Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia). somnolence AE CTCAE:E12814 HPO: HP_0001262 MedDRA:10041349 NCIt:C26754 SIDER: C2830004 OAE:0000393 a behavior and neurological AE that has an outcome of abnormal crying in a patient YH crying abnormal AE MedDRA: 10011469 OAE:0000394 a sensory capability AE that has an outcome of chills YH feeling cold AE Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold. chills AE CTCAE: E11074 HPO: HP_0001945 MedDRA: 10008531 NCIt: C35143 SIDER: C0085593 OAE:0000396 a gustatory system AE which demonstrates a decreased sensation of appetite. YH, MW anorexia nervosa AE decreased appetite AE WEB: http://www.mayoclinic.org/diseases-conditions/anorexia/basics/definition/con-20033002 anorexia AE HPO: HP_0002039 MedDRA: 10002649 (anorexia nervosa); MedDRA: 10061428 (decreased appetite); MedDRA: 10002646 (anorexia). SIDER: C0003123 OAE:0000398 an abnormal respiration AE that shows a sudden and often repetitively occurring reflex to keep the throat and airways clear YH, SS, MW coughing AE WEB: http://medical-dictionary.thefreedictionary.com/cough WEB: http://www.nlm.nih.gov/medlineplus/cough.html cough cough AE CTCAE:E13364 MedDRA:10011224 NCIt:C37935 OAE:0000399 a syndrome AE that has an outcome of a flu syndrome AE and occurs after a medical intervention. YH flu-like symptom AE flu syndrome AE CTCAE: E11108 NCIt: C78302 OAE:0000400 a sensory capability AE that has an outcome of loss of consciousness, fainting YH, SS, MW Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness. fainting WEB: http://en.wikipedia.org/wiki/Syncope_%28medicine%29 WEB: http://en.wikipedia.org/wiki/Unconsciousness syncope AE CTCAE:E12832 HPO: HP_0001279 MedDRA: 10024855 MedDRA:10042772 NCIt:C35053 SIDER: C0039070 OAE:0000402 According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). YH, SS WEB: http://en.wikipedia.org/wiki/Abdominal_pain a pain AE that is observed in abdominal cavity abdominal pain AE HPO: HP_0002027 MedDRA ID: 10000081 SIDER: C0000737 OAE:0000403 an abnormal blood pressure AE that has an outcome of sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states YH, SS, MW blood pressure increased WEB: http://www.ncbi.nlm.nih.gov/pubmed/21722707 hypertension AE CTCAE:E13785 HPO: HP_0000822 MP: MP_0000231 MedDRA: 10005750 MedDRA:10020772 NCIt:C3117 SIDER: C0020538 OAE:0000419 a skin adverse event that has an outcome of skin nodule According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). YH skin nodule AE HPO: HP_0200036 SIDER: C0037287 OAE:0000427 a cardiovascular disorder AE that has an outcome of hemorrhage bleeding AE haemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/hemorrhage loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels hemorrhage AE MP: MP_0001914 MedDRA: 10055798 OAE:0000434 a respiratory system AE which has an outcome of lung disorder YH lung disorder AE lung AE HPO: HP_0006552 MedDRA: 10025082 SIDER: C0024115 OAE:0000435 a musculoskeletal system AE that occurs in muscle. YH muscle AE OAE:0000439 an AE that occurs in digestive system. YH digestive system AE OAE:0000442 a musculoskeletal system AE which has an outcome of joint disorder YH joint disorder AE OAE:0000455 a digestive system AE which has an outcome of a gastrointestinal disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH gastrointestinal disorder AE HPO: HP_0011024 SIDER: C0017178 OAE:0000465 an AE that occurs in ear. YH ear disorder AE ear AE HPO: HP_0000598 SIDER: C0013447 OAE:0000476 an AE that occurs in immune system. According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder' was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH immune system disorder AE immune system AE HPO: HP_0002715 SIDER: C0021053 OAE:0000490 a syndrome AE that has an outcome of an acute brain syndrome AE and occurs after a medical intervention. YH acute brain syndrome AE OAE:0000493 an AE that occurs in cardiovascular system. YH cardiovascular disorder AE cardiovascular AE HPO: HP_0001626 MedDRA ID: 10007649 SIDER: C0007222 OAE:0000538 a respiratory system AE which has an outcome of sore throat YH, MW sore throat AE MedDRA: 10041367 OAE:0000543 a hair, skin, and nail AE that occurs in skin. YH WEB: http://www.thefreedictionary.com/skin+disorder skin AE MedDRA: 10040831 OAE:0000546 a homeostasis AE which has an outcome of abnormal fluid regulation, which is any anomaly in the control of intracellular and/or extracellular fluid abnormal fluid regulation AE MP: MP_0001784 OAE:0000551 an abnormal blood pressure AE that has an outcome of sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states YH, MW blood pressure decreased, low blood pressure hypotension AE CTCAE:E13791 HPO: HP_0002615 MP: MP_0001596 MedDRA: 10005734 MedDRA:10021097 NCIt:C3128 SIDER: C0020649 OAE:0000554 a digestive system AE which has an outcome of abnormal digestion, which is an altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy abnormal digestion AE MP: MP_0001664 OAE:0000555 an AE that occurs in the homeostasis system. anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues homeostasis AE MP: MP_0001764 OAE:0000556 an abnormal fluid regulation AE which has an outcome of edema, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues oedema, swelling, dropsy WEB: http://en.wikipedia.org/wiki/Oedema WEB: http://en.wikipedia.org/wiki/Swelling_(medical) edema AE MP: MP_0001785 MedDRA: 10016807 MedDRA: 10030095 MedDRA: 10042674 OAE:0000557 an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult. SS, YH WEB: http://en.wikipedia.org/wiki/Inflammation inflammation AE HPO: HP_0007891 MP: MP_0001846 MedDRA: 10061218 SIDER: C0021368 OAE:0000564 an inflammation AE which has an outcome of respiratory system inflammation, the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system respiratory system inflammation AE MP: MP_0002405 OAE:0000565 an inflammation AE that has an outcome of vasculitis, which is an inflammation of a blood or lymph vessel It's an inflammation. YH, MW vasculitis AE CTCAE:E13837 HPO: HP_0002633 MP: MP_0001864 MedDRA:10047115 NCIt:C26912 SIDER: C0042384 OAE:0000571 a respiratory system AE which has an outcome of abnormal respiration, an anomaly in the movement of gases into and out of the lung According to the Vaccine Adverse Event Reporting System (VAERS), 'respiratory disorder' is an adverse event that was mentioned in 556 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). Not sure if it is same as respiratory system disorder or abnormal respiration. --Oliver He abnormal respiration AE MP: MP_0001943 OAE:0000574 an adverse event that occurs in a gustatory system YH, JX gustatory system AE MP: MP_0001985 OAE:0000580 an adverse event that has an outcome of an abnormal behavior and neurological phenotype. YH, JX behavior AE behavioral AE behavioral disorder AE disruptive behavioral disorder AE WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/ any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls behavioral and neurological AE MP: MP_0004924 OAE:0000581 a behavior and neurological AE that has an outcome of altered ability to coordinate voluntary movement or repetitive, compulsive movements movement disorder AE HPO: HP_0100022 MP: MP_0002066 MedDRA ID: 10028035 SIDER: C0026650 OAE:0000582 a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus sensory capability AE MP: MP_0002067 OAE:0000584 Hypersensitivity AE is a immune system AE that is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. These reactions may be damaging, uncomfortable, or occasionally fatal. JX, LW, YH hypersensitivity reaction AE WEB: http://en.wikipedia.org/wiki/Hypersensitivity 超敏反应 hypersensitivity AE HPO: HP_0100326 MP: MP_0002148 MedDRA ID: 10020751 MedDRA: 10020751 SIDER: C0020517 OAE:0000600 an abnormal digestion AE which has an outcome of nausea, a gastric discomfort associated with the inclination to vomit nausea AE HPO: HP_0002018 MP: MP_0003259; MDR: 10028813 MedDRA ID: 10028813 MedDRA: 10028813 SIDER: C0027497 OAE:0000601 regurgitation AE an abnormal digestion AE which has an outcome of vomiting, the retrograde expulsion of gastric contents through the oral cavity vomiting AE CTCAE: E11068 HPO: HP_0002013 MP: MP_0003260; MDR: 10047700 MedDRA ID: 10047700 MedDRA: 10047700 NCIt: C3442 SIDER: C0042963 OAE:0000603 a digestive system AE that has an outcome of abnormal defecation, an anomaly in the production and excretion of feces abnormal defecation AE MP: MP_0003866 OAE:0000616 an abnormal defecation AE that has an outcome of diarrhea, which is abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel diarrhoea AE WEB: http://medical-dictionary.thefreedictionary.com/diarrhea diarrhea AE MP: MP_0005036 MedDRA: 10012735 OAE:0000624 a homeostasis AE whic has an outcome of abnomal body temperature, which is a deviation in the level of heat natural to a living being abnormal body temperature AE MP: MP_0005535 OAE:0000630 a hemorrhage AE that has an outcome of ecchymosis an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis ecchymosis AE HPO: HP_0000978 MP: MP_0009276 MedDRA ID: 10014080 SIDER: C0013491 OAE:0000639 low-grade fever AE is a fever adverse event with a temperature between 100° F and 102.2° F (37.8° C and 39° C). YH WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 The low-grade level of fever is beneficial. With most microbes/"bugs" that a child will be exposed to, this fever will assist the body in repelling the invader. low-grade fever AE OAE:0000643 a pain AE that has an outcome of musculoskeletal pain SS, YH WEB: http://www.webmd.com/pain-management/guide/musculoskeletal-pain Musculoskeletal pain is pain that affects the muscles, ligaments and tendons, along with the bones. musculoskeletal pain AE HPO: HP_0003326 MedDRA ID: 10028391 SIDER: C0026858 OAE:0000644 injection-site erythema AE is an erythema AE that results in redness of skin, caused by hyperermia of the capillaries in the lower layers of the skin at the physical area of injection SS, YH WEB: http://en.wikipedia.org/wiki/Erythema WEB: http://medical-dictionary.thefreedictionary.com/erythema injection-site erythema AE MedDRA: 10022061 OAE:0000645 Erythema AE is a skin adverse event that showns redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin. SS, YH reddish skin WEB: http://en.wikipedia.org/wiki/Erythema erythema AE HPO: HP_0010783 MP:0001190 MedDRA ID: 10015150 MedDRA: 10015150 SIDER: C0041834 OAE:0000650 an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise. YH: MedDRA ID: 10018852 is for "haematoma"; MedDRA ID: 10019428 is for "hematoma". SS, YH bruise AE ecchymoses AE haematoma AE WEB: http://en.wikipedia.org/wiki/Hematoma hematoma AE CTCAE: E11666 HPO: HP_0001892 MedDRA ID: 10018852; MedDRA ID: 10019428 NCIt: C37921 SIDER: C0018944 OAE:0000698 SS, YH WEB: http://en.wikipedia.org/wiki/Vasodilation a cardiovascular disorder AE which has an outcome of vasodilatation, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. vasodilatation AE HPO: HP_0004927 SIDER: C0595862 OAE:0000770 a lung disorder AE that has an outcome of a sudden constriction of the muscles in the walls of the bronchioles DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/bronchospasm bronchospasm AE CTCAE:E13352 HPO: HP_0002099 MedDRA:10006482 NCIt:C34439 SIDER: C0006266 OAE:0000779 a cardiovascular disorder AE that results in the inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body DJ, SS, YH heart failure WEB: http://medical-dictionary.thefreedictionary.com/cardiac+failure cardiac failure AE CTCAE: E10124 HPO: HP_0001635 MedDRA: 10007554 NCIt: C50577 SIDER: C0018801 OAE:0000785 a cardiovascular disorder AE that has an outcome of deterioration of the function of the myocardium, usually leads to heart failure DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy WEB: https://en.wikipedia.org/wiki/Cardiomyopathy cardiomyopathy AE HPO: HP_0001638 MedDRA: 10007636 SIDER: C0878544 OAE:0001105 Behavior and Neurological AE that results in the patient being easily annoyed/irritated SZ, DJ, SS, YH feverish (subjective) AE irritability AE CTCAE: E11144 HPO: HP_0000737 MedDRA: 10022998 NCIt: C50623 SIDER: C0022107 OAE:0001139 an edema AE occuring in a specific region SZ, DJ, SS, YH localised edema AE localised oedema AE WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115975/ localized edema AE CTCAE: E11148 HPO: HP_0000969 MedDRA: 10048961 NCIt: C78437 SIDER: C0013609 OAE:0001147 an immune system disorder AE that has an outcome of lymphadenopathy, which is a term meaning "disease of the lymph nodes" . It is generally a disease or inflammation of the lymph nodes, could be due to infection, auto-immune disease or malignancy SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/lymphadenopathy lymphadenopathy AE HPO: HP_0002716 MedDRA: 10025197 SIDER: C0497156 OAE:0001403 a behavior and neurological AE that results in irregular sleep patterns SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sleep+disorder sleep disorder AE HPO: HP_0002360 MedDRA: 10040984 SIDER: C0851578 OAE:0001546 an injection-site AE that display an redness in the injection-site YH injection-site redness AE OAE:0001547 a sensory capability AE that shows up skin tenderness and occurs in an injection site of a medical intervention YH injection-site tenderness AE MedDRA: 10043224 OAE:0001548 YH a movement disorder AE that has an outcome of arm motion limitation arm motion limitation AE OAE:0001549 a sensory capability AE that shows up muscular soreness at the injection site of a medical intervention YH injection-site muscular soreness AE MedDRA: 10028332 OAE:0001550 a sleep disorder AE that shows up sleepiness (Sluggish from sleep, inactive, quiet). YH sleepiness AE MedDRA: 10041014 OAE:0001552 a hypersensitivity AE that is mild. YH mild hypersensitivity AE OAE:0001553 YH an injection-site edema AE that occurs in the arm. injection-site arm edema AE OAE:0001554 a psychiatric disorder AE that shows restlessness YH, MW WEB: http://dictionary.reference.com/browse/restlessness restlessness AE CTCAE:E12960 MedDRA:10038743 NCIt:C74533 UMLS_CUI: C0085631 OAE:0001555 a sensory capability AE that results in a sensation of induration with tenderness. YH induration with tenderness AE OAE:0001556 a sensory capability AE that results in a sensation of fussiness YH fussiness AE OAE:0001557 a sleep disorder AE that shows decreased sleep YH decreased sleep AE OAE:0001558 a sleep disorder AE that shows increased sleep YH increased sleep AE OAE:0001559 a pain AE that occurs at a joint YH joint pain AE OAE:0001560 Tiredness AE is a sensory capability AE that results in a sensation of tiredness. This term appears to be a synonym to the 'fatigue AE'. JX, LW, YH hypodynamia AE 疲劳/乏力 tiredness AE MedDRA: 10043890 OAE:0001750 a process quality that represents the level of severity of an adverse event. YH, SS AE severity severity of adverse event OAE:0001797 a behavior and neurological AE that has an outcome of a mental illness or psychiatiric disorder. The mental illness is a mental or behavioral pattern or anomaly that causes either suffering or an impaired ability to function in ordinary life (disability), and which is not developmentally or socially normative. YH, Izabela Birsanescu mental disorder AE WEB: http://en.wikipedia.org/wiki/Mental_disorder psychiatric disorder AE MedDRA ID: 10037175 OAE:0001836 a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated. YH, SS AE severity Grade 1 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_1_Adverse_Event Note the AE severity Grade 1 equals to CTCAE G1 AE severity. AE severity G1 CTCAE4: E10005 (Grade 1 Adverse Event) OAE:0001837 a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances). YH, SS AE severity Grade 2 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_2_Adverse_Event Note the AE severity Grade 2 equals to CTCAE G2 AE severity. AE severity G2 CTCAE4: E10006 (Grade 2 Adverse Event) OAE:0001838 a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet). YH, SS AE severity Grade 3 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_3_Adverse_Event Note the AE severity Grade 3 equals to CTCAE G3 AE severity. AE severity G3 CTCAE4: E10007 (Grade 3 Adverse Event) OAE:0001839 a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral). YH, SS AE severity Grade 4 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_4_Adverse_Event Note the AE severity Grade 4 equals to CTCAE G4 AE severity. AE severity G4 CTCAE4: E10008 (Grade 4 Adverse Event) OAE:0001840 a severity of AE that results in death. YH, SS AE severity Grade 5 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_5_Adverse_Event Note the AE severity Grade 5 equals to CTCAE G5 AE severity. AE severity G5 CTCAE4: E10009 (Grade 5 Adverse Event) OAE:0002625 an adverse event that occurs locally in a certain location. This is different from the systematci adverse event that occurs throughout the systemtic circulation. YH, JX URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction local AE OAE:0003230 YH, JX a behavioral quality where the behavior in an organism is abnormal. WEB: https://en.wikipedia.org/wiki/Abnormality_(behavior) behavior abnormal quality OBI:0000011 planned process Injecting mice with a vaccine in order to test its efficacy A processual entity that realizes a plan which is the concretization of a plan specification. 'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.) Bjoern Peters branch derived 6/11/9: Edited at workshop. Used to include: is initiated by an agent This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call) planned process OBI:0000047 processed material Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples Is a material entity that is created or changed during material processing. PERSON: Alan Ruttenberg processed material OBI:0000245 organization PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods. An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members. PERSON: Alan Ruttenberg PERSON: Bjoern Peters PERSON: Philippe Rocca-Serra PERSON: Susanna Sansone GROUP: OBI organization OBI:0000319 material to be added role drug added to a buffer contained in a tube; substance injected into an animal; material to be added role is a protocol participant role realized by a material which is added into a material bearing the target of material addition role in a material addition process Role Branch OBI 9 March 09 from discussion with PA branch material to be added role OBI:0000444 target of material addition role peritoneum of an animal receiving an interperitoneal injection; solution in a tube receiving additional material; location of absorbed material following a dermal application. target of material addition role is a role realized by an entity into which a material is added in a material addition process From Branch discussion with BP, AR, MC -- there is a need for the recipient to interact with the administered material. for example, a tooth receiving a filling was not considered to be a target role. GROUP: Role Branch OBI target of material addition role OBI:0000725 host role In biology, a host is an organism that harbors a virus or parasite, or a mutual or commensal symbiont, typically providing nourishment and shelter. http://en.wikipedia.org/wiki/Host_(biology) 30 March 09 host role is a role played by an organism and realized by providing nourishment, shelter or a means of reproduction to another organism within the organism playing the host role 30Mar09 virus reproducing inside a cell; bacteria causing a disease, host can be harmed or not. we want to avoid a cat sitting on my lap and an animal care technician; these are not examples or hosts; dental cares = on tooth, but part of outer layer of tooth, so covered by "within" in the definition GROUP: Role Branch 30 Mar09 submitted by vaccine community OBI http://en.wikipedia.org/wiki/Host_(biology) host role OBI:0100026 organism animal fungus plant virus A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. 10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and 'other organisms') GROUP: OBI Biomaterial Branch WEB: http://en.wikipedia.org/wiki/Organism organism OBI:0600007 administering substance in vivo Balb/c mice received an intracameral or subconjunctival injection of trinitrophenylated spleen cells injecting mice with 10 ug morphine intranasally, a patient taking two pills of 1 mg aspirin orally A process by which a substance is intentionally given to an organism resulting in exposure of the organism to that substance. 2009-11-10. Tracker: https://sourceforge.net/tracker/?func=detail&aid=2893050&group_id=177891&atid=886178 Different routes and means of administration should go as children underneath this needs roles such as perturber and perturbee (children of input role). Perturb is too strong. Host might be the name for one role. Others considered: Doner, Donated, Acceptor. Bjoern Peters Person:Bjoern Peters IEDB administering substance in vivo OGG:0000000001 A genome is a material entity that represents the entirety of an organism's hereditary information. The genome includes both the genes and the non-coding sequences of the DNA and RNA. Oliver He Book: Eugene Nester, Denise Anderson, C. Evans Roberts, Jr., Microbiology (Companion Site): A Human Perspective, 7th Edition. Mcgraw Hill, October 18, 2011. ISBN-13: 978-0073375311 WEB: http://en.wikipedia.org/wiki/Genome genome OGG:0000000002 A gene is a material entity that represents the entire DNA sequence required for synthesis of a functional protein or RNA molecule. Oliver He WEB: http://www.ncbi.nlm.nih.gov/books/NBK21640/ In addition to the coding regions (exons), a gene includes transcription-control regions and sometimes introns. Although the majority of genes encode proteins, some encode tRNAs, rRNAs, and other types of RNA. gene OGG:1000000002 The genome of an organism of Bacteria Yue Liu, Bin Zhao, Oliver He 2 genome of Bacteria OGG:1000001224 The genome of an organism of Proteobacteria Yue Liu, Bin Zhao, Oliver He 1224 genome of Proteobacteria OGG:2000000002 A gene of an organism of Bacteria Yue Liu, Bin Zhao, Oliver He 2 gene of Bacteria OGG:2000001224 A gene of an organism of Proteobacteria Yue Liu, Bin Zhao, Oliver He 1224 gene of Proteobacteria OGMS:0000060 Albert Goldfain creation date: 2009-06-23T11:53:49Z bodily process OGMS:0000061 A bodily process that is clinically abnormal. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:54:29Z pathological bodily process OVAE:0000001 a vaccine adverse event that is associated with administration of a bacterial vaccine Yongqun He bacterial vaccine adverse event OVAE:0000002 a vaccine adverse event that is associated with administration of a virus vaccine Yongqun He virus vaccine adverse event OVAE:0000003 a vaccine adverse event that is associated with administration of a parasite vaccine Yongqun He parasite vaccine adverse event OVAE:0000004 a vaccine adverse event that is associated with administration of a fungal vaccine Yongqun He fugal vaccine adverse event OVAE:0000005 a vaccine adverse event that is associated with administration of a cancer vaccine Yongqun He cancer vaccine adverse event OVAE:0000006 a vaccine adverse event that is associated with administration of a bacterial and viral combination vaccine Yongqun He bacterial and viral combination vaccine adverse event OVAE:0000007 Yongqun He, Erica Marcos adverse event associated with Diphtheria & Tetanus Toxoids Absorbed OVAE:0000008 Yongqun He, Erica Marcos Engerix-B vaccine adverse event OVAE:0000009 An influenza vaccine adverse event that is associated with the administration of Flublok. Yongqun He, Erica Marcos Flublok vaccine adverse event OVAE:0000010 An influenza vaccine adverse event that is associated with the administration of Fluarix. Yongqun He, Erica Marcos Fluarix vaccine adverse event OVAE:0000011 An influenza vaccine adverse event that is associated with the administration of Fluarix Quadrivalent vaccine. Yongqun He, Erica Marcos Fluarix Quadrivalent vaccine adverse event OVAE:0000012 An influenza vaccine adverse event that is associated with the administration of Flucelvax. Yongqun He, Erica Marcos Flucelvax vaccine adverse event OVAE:0000013 An influenza vaccine adverse event that is associated with the administration of Flulaval. Yongqun He, Erica Marcos Flulaval vaccine adverse event OVAE:0000014 An influenza vaccine adverse event that is associated with the administration of FluMist Quadrivalent vaccine. Yongqun He, Erica Marcos FluMist Quadrivalent vaccine adverse event OVAE:0000015 An influenza vaccine adverse event that is associated with the administration of Fluvirin. Yongqun He, Erica Marcos Fluvirin vaccine adverse event OVAE:0000016 An influenza vaccine adverse event that is associated with the administration of Fluzone. Yongqun He, Erica Marcos Fluzone vaccine adverse event OVAE:0000017 An influenza vaccine adverse event that is associated with the administration of Fluzone High-dose vaccine. Yongqun He, Erica Marcos Fluzone High-Dose vaccine adverse event OVAE:0000018 An influenza vaccine adverse event that is associated with the administration of Fluzone intradermal vaccine. Yongqun He, Erica Marcos Fluzone Intradermal vaccine adverse event OVAE:0000019 Yongqun He, Erica Marcos Gardasil vaccine adverse event OVAE:0000020 Yongqun He, Erica Marcos Havrix vaccine adverse event OVAE:0000021 Yongqun He, Erica Marcos Hiberix vaccine adverse event OVAE:0000022 Yongqun He, Erica Marcos Imovax Rabies vaccine adverse event OVAE:0000023 Yongqun He, Erica Marcos Infanrix vaccine adverse event OVAE:0000024 An influenza vaccine adverse event that is associated with the administration of Influenza virus vaccine H5N1 vaccine. Yongqun He, Erica Marcos Influenza Virus Vaccine H5N1 vaccine adverse event OVAE:0000025 Yongqun He, Erica Marcos IPOL vaccine adverse event OVAE:0000026 Yongqun He, Erica Marcos Ixiaro vaccine adverse event OVAE:0000027 Yongqun He, Erica Marcos JE-Vax vaccine adverse event OVAE:0000028 Yongqun He, Erica Marcos Kinrix vaccine adverse event OVAE:0000029 Yongqun He, Erica Marcos Menactra vaccine adverse event OVAE:0000030 Yongqun He, Erica Marcos MenHibrix vaccine adverse event OVAE:0000031 Yongqun He, Erica Marcos Menomune-A/C/Y/W-135 vaccine adverse event OVAE:0000032 Yongqun He, Erica Marcos Menveo vaccine adverse event OVAE:0000033 Yongqun He, Erica Marcos Meruvax II vaccine adverse event OVAE:0000034 Yongqun He, Erica Marcos Pediarix vaccine adverse event OVAE:0000035 Yongqun He, Erica Marcos PedvaxHIB vaccine adverse event OVAE:0000036 Yongqun He, Erica Marcos Pentacel vaccine adverse event OVAE:0000037 Yongqun He, Erica Marcos Pneumovax 23 vaccine adverse event OVAE:0000038 Yongqun He, Erica Marcos Prevnar vaccine adverse event OVAE:0000039 Yongqun He, Erica Marcos Prevnar 13 vaccine adverse event OVAE:0000040 Yongqun He, Erica Marcos ProQuad vaccine adverse event OVAE:0000041 Yongqun He, Erica Marcos RabAvert vaccine adverse event OVAE:0000042 Yongqun He, Erica Marcos Recombivax HB vaccine adverse event OVAE:0000043 Yongqun He, Erica Marcos Rotarix vaccine adverse event OVAE:0000044 Yongqun He, Erica Marcos RotaTeq vaccine adverse event OVAE:0000045 Yongqun He, Erica Marcos Tenivac vaccine adverse event OVAE:0000046 Yongqun He, Erica Marcos adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological OVAE:0000047 Yongqun He Tetanus Toxoid (boost only) vaccine adverse event OVAE:0000048 Yongqun He, Erica Marcos Tetanus Toxoid Absorbed vaccine adverse event OVAE:0000049 Yongqun He, Erica Marcos Tripedia vaccine adverse event OVAE:0000050 Yongqun He, Erica Marcos Twinrix vaccine adverse event OVAE:0000051 Yongqun He, Erica Marcos Typhim Vi vaccine adverse event OVAE:0000052 Yongqun He, Erica Marcos Vaqta vaccine adverse event OVAE:0000053 Yongqun He, Erica Marcos Varivax vaccine adverse event OVAE:0000054 Yongqun He, Erica Marcos Vivotif vaccine adverse event OVAE:0000055 Yongqun He, Erica Marcos YF-Vax vaccine adverse event OVAE:0000056 Yongqun He, Erica Marcos Zostavax vaccine adverse event OVAE:0000060 An influenza vaccine adverse event that is associated with the administration of Agriflu. Yongqun He, Erica Marcos Agriflu vaccine adverse event OVAE:0000061 Yongqun He, Erica Marcos Biothrax vaccine adverse event 0.11 50 64 OVAE:0000062 A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a muscle pain AE Yongqun He, Jiangan Xie WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Flublok-associated muscle pain AE OVAE:0000063 Yongqun He, Erica Marcos Boostrix vaccine adverse event OVAE:0000064 Yongqun He, Erica Marcos Cervarix vaccine adverse event OVAE:0000065 Yongqun He, Erica Marcos Comvax vaccine adverse event OVAE:0000066 Yongqun He, Erica Marcos Daptacel vaccine adverse event OVAE:0000067 Yongqun He, Erica Marcos Decavac vaccine adverse event OVAE:0000070 a virus vaccine adverse event that is associated with administration of an influenza virus vaccine Yongqun He influenza vaccine adverse event OVAE:0000072 a bacterial adverse event that is associated with administration of a Haemophilus vaccine Yongqun He Haemophilus vaccine adverse event OVAE:0000073 a virus vaccine adverse event that is associated with administration of an adenovirus vaccine Yongqun He adenovirus vaccine adverse event OVAE:0000074 an adenovirus vaccine adverse event that is associated with administration of an adenovirus vaccine Adenovirus Type 4 and Type 7 Vaccine, Live, Oral Yongqun He adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral OVAE:0000075 a virus vaccine adverse event that is associated with administration of a human papillomavirus vaccine Yongqun He human papillomavirus vaccine adverse event OVAE:0000076 a bacterial adverse event that is associated with administration of a Bacillus anthracis vaccine Yongqun He Bacillus anthracis vaccine adverse event OVAE:0000078 Yongqun He, Erica Marcos Streptococcus pneumoniae vaccine adverse event OVAE:0000079 Yongqun He, Erica Marcos Neisseria meningitidis vaccine adverse event OVAE:0000100 a bacterial vaccine adverse event that is associated with administration of diphtheria vaccine Yongqun He diphtheria vaccine adverse event OVAE:0000101 a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus vaccine Yongqun He Diphtheria-Tetanus vaccine adverse event OVAE:0000102 a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis vaccine Yongqun He Diphtheria-Tetanus-Pertussis vaccine adverse event OVAE:0000103 a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Poliovirus vaccine Yongqun He Diphtheria-Tetanus-Poliovirus vaccine adverse event OVAE:0000104 a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis-Poliovirus vaccine Yongqun He Diphtheria-Tetanus-Pertussis-Poliovirus vaccine adverse event OVAE:0000105 a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine Yongqun He Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine adverse event OVAE:0000106 a bacterial vaccine adverse event that is associated with administration of Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine Yongqun He Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine adverse event OVAE:0000107 a bacterial vaccine adverse event that is associated with administration of Salmonella vaccine Yongqun He Salmonella vaccine adverse event OVAE:0000108 a viral vaccine adverse event that is associated with administration of Haemophilus b and Hepatitis B vaccine Yongqun He Haemophilus b and Hepatitis B vaccine adverse event OVAE:0000109 a viral vaccine adverse event that is associated with administration of Hepatitis A virus vaccine Yongqun He Hepatitis A virus vaccine adverse event OVAE:0000110 a viral vaccine adverse event that is associated with administration of Hepatitis A&B vaccine Yongqun He Hepatitis A&B vaccine adverse event OVAE:0000111 a viral vaccine adverse event that is associated with administration of Hepatitis B virus vaccine Yongqun He Hepatitis B virus vaccine adverse event OVAE:0000112 a viral vaccine adverse event that is associated with administration of Herpesvirus vaccine Yongqun He Herpesvirus vaccine adverse event OVAE:0000113 a viral vaccine adverse event that is associated with administration of Japanese encephalitis virus vaccine Yongqun He Japanese encephalitis virus vaccine adverse event OVAE:0000114 a viral vaccine adverse event that is associated with administration of Measles virus vaccine Yongqun He Measles virus vaccine adverse event OVAE:0000115 a viral vaccine adverse event that is associated with administration of Measles-Mumps-Rubella-Vericella vaccine Yongqun He Measles-Mumps-Rubella-Vericella vaccine adverse event OVAE:0000116 a viral vaccine adverse event that is associated with administration of Poliovirus vaccine Yongqun He Poliovirus vaccine adverse event OVAE:0000117 a viral vaccine adverse event that is associated with administration of smallpox vaccine Yongqun He smallpox vaccine adverse event OVAE:0000118 a viral vaccine adverse event that is associated with administration of Rabies vaccine Yongqun He Rabies vaccine adverse event OVAE:0000119 a viral vaccine adverse event that is associated with administration of Rotavirus vaccine Yongqun He Rotavirus vaccine adverse event OVAE:0000120 a viral vaccine adverse event that is associated with administration of Rubella vaccine Yongqun He Rubella vaccine adverse event OVAE:0000121 a viral vaccine adverse event that is associated with administration of Yellow fever vaccine Yongqun He Yellow fever vaccine adverse event 0.1 65 0.4 18 64 0.6 5 17 OVAE:0000201 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated injection-site pain AE 0.2 5 17 OVAE:0000202 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated injection-site redness AE 0.1 5 17 OVAE:0000203 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated local swelling AE 0.2 18 64 0.2 5 17 OVAE:0000204 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated headache AE 0.2 5 17 OVAE:0000205 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated myalgia AE 0.1 5 17 0.2 18 64 OVAE:0000206 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated malaise AE 0.1 5 17 OVAE:0000207 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated fever AE 0.3 65 0.6 18 64 OVAE:0000208 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated injection-site tenderness AE 0.2 18 64 OVAE:0000212 A Afluria vaccine adverse event that is associated with an administration of Afluria and displays an muscle ache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM263239.pdf Afluria-associated muscle ache AE 0.1 18 OVAE:0000213 A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM192127.pdf Agriflu-associated injection-site pain AE 0.1 18 OVAE:0000214 A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM192127.pdf Agriflu-associated headache AE 0.1 18 OVAE:0000215 A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM192127.pdf Agriflu-associated myalgia AE 0.1 18 OVAE:0000216 A Afluria vaccine adverse event that is associated with an administration of Agriflu and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM192127.pdf Agriflu-associated malaise AE 18 0.51 OVAE:0000217 A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf Flulaval-associated injection-site pain AE 18 0.13 OVAE:0000218 A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf Flulaval-associated injection-site redness AE 18 0.11 OVAE:0000219 A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf Flulaval-associated local swelling AE 18 0.2 OVAE:0000220 A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf Flulaval-associated fatigue AE 18 0.18 OVAE:0000221 A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf Flulaval-associated headache AE 18 0.18 OVAE:0000222 A Flulaval vaccine adverse event that is associated with an administration of Flulaval and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112904.pdf Flulaval-associated myalgia AE 3 5 0.17 OVAE:0000223 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated drowsiness 3 5 0.17 OVAE:0000224 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated irritability AE 3 5 0.16 OVAE:0000225 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated decreased appetite AE 6 7 0.1 OVAE:0000229 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated arthralgia AE 6 7 0.1 OVAE:0000230 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an gastrointestinal disorder AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated gastrointestinal disorder AE 3 17 0.23 OVAE:0000232 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated injection-site redness AE 3 17 0.19 OVAE:0000233 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated local swelling AE 18 0.36 3 17 0.44 OVAE:0000234 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated injection-site pain AE 18 0.16 6 7 0.18 OVAE:0000235 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an muscle ache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated muscle ache AE 18 0.16 6 7 0.16 OVAE:0000236 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated headache AE 18 0.16 6 7 0.2 OVAE:0000237 A Flulaval vaccine adverse event that is associated with an administration of Fluarix and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM335392.pdf Fluarix-associated fatigue AE 0.19 65 0.32 50 64 0.37 18 49 OVAE:0000238 A Flublok vaccine adverse event that is associated with an administration of Flublok and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Flublok-associated injection-site pain AE 0.10 65 0.15 18 49 0.15 50 64 OVAE:0000239 A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Flublok-associated headache AE 0.13 50 64 0.13 65 0.15 18 49 OVAE:0000240 A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a fatigue AE Yongqun He, Erica Marcos, Jiangan Xie WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Flublok-associated fatigue AE 0.11 18 49 OVAE:0000241 A Flublok vaccine adverse event that is associated with an administration of Flublok and displays a myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM336020.pdf Flublok-associated myalgia AE 18 64 0.28 OVAE:0000242 A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Flucelvax-associated injection-site pain AE 18 64 0.11 OVAE:0000246 A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Flucelvax-associated myalgia AE 18 64 0.13 65 0.1 OVAE:0000248 A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Flucelvax-associated injection-site erythema AE 18 64 0.12 65 0.11 OVAE:0000249 A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Flucelvax-associated fatigue AE 18 64 0.16 65 0.1 OVAE:0000250 A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Flucelvax-associated headache AE 18 0.1 OVAE:0000251 A Flucelvax vaccine adverse event that is associated with an administration of Flucelvax and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM329134.pdf Flucelvax-associated malaise AE OVAE:0000252 A Fluvirin vaccine adverse event that is associated with an administration of Fluvirin and displays an mild hypersensitity AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123694.pdf Fluvirin-associated mild hypersensitity AE 4 OVAE:0000253 A Fluvirin vaccine adverse event that is associated with an administration of Fluvirin and displays an flu-like syndrome AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123694.pdf Fluvirin-associated flu-like syndrome AE 0.5 0.5 8 OVAE:0000254 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated injection-site tenderness AE 0.25 0.5 8 OVAE:0000255 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated injection-site redness AE 0.25 0.5 2.9 OVAE:0000256 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated irritability AE 0.25 0.5 2.9 OVAE:0000257 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated drowsiness 0.2 3 8 OVAE:0000258 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated myalgia AE 0.5 18 64 OVAE:0000259 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated injection-site pain AE 0.3 18 64 OVAE:0000260 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated headache AE 0.3 18 64 OVAE:0000261 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated myalgia AE 0.2 65 OVAE:0000262 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated injection-site pain AE 0.1 65 OVAE:0000263 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated headache AE 0.1 65 OVAE:0000264 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated myalgia AE 0.1 65 OVAE:0000265 A Fluzone vaccine adverse event that is associated with an administration of Fluzone and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305089.pdf Fluzone-associated malaise AE 0.3 65 OVAE:0000266 A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Fluzone High-Dose-associated injection-site pain AE 0.1 65 OVAE:0000267 A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Fluzone High-Dose-associated headache AE 0.1 65 OVAE:0000268 A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Fluzone High-Dose-associated myalgia AE 0.1 65 OVAE:0000269 A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Fluzone High-Dose-associated erythema AE 0.1 65 OVAE:0000270 A Fluzone High-Dose vaccine adverse event that is associated with an administration of Fluzone High-Dose and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Fluzone High-Dose-associated malaise AE 0.75 18 64 OVAE:0000271 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated injection-site erythema AE 0.5 18 64 OVAE:0000272 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated injection-site induration AE 0.5 18 64 OVAE:0000273 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated local swelling AE 0.5 18 64 OVAE:0000274 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated injection-site pain AE 0.4 18 64 OVAE:0000275 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an OAE_0000373 Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated OAE_0000373 0.2 18 64 OVAE:0000276 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated headache AE 0.2 18 64 OVAE:0000277 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated myalgia AE 0.2 18 64 OVAE:0000278 A Fluzone Intradermal vaccine adverse event that is associated with an administration of Fluzone Intradermal and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Fluzone Intradermal-associated malaise AE 0.1 2 6 OVAE:0000279 A FluMist vaccine adverse event that is associated with an administration of FluMist and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf FluMist-associated fever AE 0.1 2 49 OVAE:0000280 A FluMist vaccine adverse event that is associated with an administration of FluMist and displays an nasal congestion AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf FluMist-associated nasal congestion AE 0.1 18 49 OVAE:0000281 A FluMist vaccine adverse event that is associated with an administration of FluMist and displays an sore throat AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf FluMist-associated sore throat AE 18 49 0.44 2 17 0.32 OVAE:0000283 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of FluMist Quadrivalent and displays an nasal congestion AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM294307.pdf FluMist Quadrivalent-associated nasal congestion AE 2 17 0.07 OVAE:0000285 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of FluMist Quadrivalent and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM294307.pdf FluMist Quadrivalent-associated fever AE 18 49 0.19 OVAE:0000286 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of FluMist Quadrivalent and displays an sore throat AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM294307.pdf FluMist Quadrivalent-associated sore throat AE 18 0.36 3 17 0.44 OVAE:0000291 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated injection-site pain AE 3 17 0.23 OVAE:0000292 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated injection-site redness AE 3 17 0.19 OVAE:0000293 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated local swelling AE 3 5 0.17 OVAE:0000294 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated drowsiness 3 5 0.17 OVAE:0000295 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated irritability AE 3 5 0.16 OVAE:0000296 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated decreased appetite AE 18 0.16 6 17 0.2 OVAE:0000297 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated fatigue AE 18 0.16 6 17 0.18 OVAE:0000298 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an muscle ache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated muscle ache AE 6 0.16 OVAE:0000299 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated headache AE 6 17 0.1 OVAE:0000300 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated arthralgia AE OVAE:0000301 A FluMist Quadrivalent vaccine adverse event that is associated with an administration of Fluarix Quadrivalent and displays an gastrointestinal disorder AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220624.pdf Fluarix Quadrivalent-associated gastrointestinal disorder AE 18 64 OVAE:0000302 A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112836.pdf Influenza Virus Vaccine H5N1-associated injection-site pain AE 18 64 OVAE:0000303 A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112836.pdf Influenza Virus Vaccine H5N1-associated headache AE 18 64 OVAE:0000304 A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112836.pdf Influenza Virus Vaccine H5N1-associated malaise AE 18 64 OVAE:0000305 A Influenza Virus Vaccine H5N1 vaccine adverse event that is associated with an administration of Influenza Virus Vaccine H5N1 and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM112836.pdf Influenza Virus Vaccine H5N1-associated myalgia AE 0.05 17 50 OVAE:0000306 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an upper respiratory tract infection AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated upper respiratory tract infection AE 0.05 17 50 OVAE:0000307 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated headache AE 0.05 17 50 OVAE:0000308 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an nasal congestion AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated nasal congestion AE 0.05 17 50 OVAE:0000309 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an pharyngolaryngeal pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated pharyngolaryngeal pain AE 0.05 17 50 OVAE:0000310 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an cough Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated cough 0.05 17 50 OVAE:0000311 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated arthralgia AE 0.05 17 50 OVAE:0000312 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated nausea AE 0.05 17 50 OVAE:0000313 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an abdominal pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated abdominal pain AE 0.05 17 50 OVAE:0000314 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated diarrhea AE 0.05 17 50 OVAE:0000315 A adverse event associated with Adenovirus Type 4 and Type 7 Vaccine, Live, Oral that is associated with an administration of Adenovirus Type 4 and Type 7 Vaccine, Live, Oral and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM247515.pdf Adenovirus Type 4 and Type 7 Vaccine, Live, Oral-associated vomiting AE 0.1 18 65 OVAE:0000316 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated injection-site tenderness AE 0.1 18 65 OVAE:0000317 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated injection-site pain AE 0.1 18 65 OVAE:0000318 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated injection-site erythema AE 0.1 18 65 OVAE:0000319 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated injection-site edema AE 0.1 18 65 OVAE:0000320 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an arm motion limitation AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated arm motion limitation AE 0.05 18 65 OVAE:0000321 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an muscle ache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated muscle ache AE 0.05 18 65 OVAE:0000322 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated fatigue AE 0.05 18 65 OVAE:0000323 A Biothrax vaccine adverse event that is associated with an administration of Biothrax and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/UCM074923.pdf Biothrax-associated headache AE 0 6 OVAE:0000324 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site redness AE 0 6 OVAE:0000325 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site warmth AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site warmth AE 0 6 OVAE:0000326 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site edema AE 0 6 OVAE:0000327 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site induration AE 0 6 OVAE:0000328 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated local swelling AE 0 6 OVAE:0000329 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an urticaria AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated urticaria AE 0 6 OVAE:0000330 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an injection-site rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated injection-site rash AE 0 6 OVAE:0000331 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated malaise AE 0 6 OVAE:0000332 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated fever AE 0 6 OVAE:0000333 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated pain AE 0 6 OVAE:0000334 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an hypotension AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated hypotension AE 0 6 OVAE:0000335 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated nausea AE 0 6 OVAE:0000336 A adverse event associated with Diphtheria & Tetanus Toxoids Absorbed that is associated with an administration of Diphtheria & Tetanus Toxoids Absorbed and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101500.pdf Diphtheria & Tetanus Toxoids Absorbed (for pediatric use)-associated arthralgia AE 0.17 6 0.1896 OVAE:0000337 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated injection-site redness AE 0.17 6 0.1428 OVAE:0000338 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated local swelling AE 0.17 6 0.065 OVAE:0000339 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated injection-site pain AE 0.17 6 0.0264 OVAE:0000340 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated fever AE 0.17 6 0.0724 OVAE:0000341 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an anorexia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated anorexia AE 0.17 6 0.0228 OVAE:0000342 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated vomiting AE 0.17 6 0.1262 OVAE:0000343 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated drowsiness 0.17 6 0.0536 OVAE:0000344 A Tripedia vaccine adverse event that is associated with an administration of Tripedia and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM101580.pdf Tripedia-associated irritability AE 0.1 0.53 0.115 6 OVAE:0000345 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated injection-site pain AE 0.1 0.53 0.115 6 OVAE:0000346 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated injection-site redness AE 0.1 0.53 0.115 6 OVAE:0000347 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated local swelling AE 0.2 0.3 0.115 6 OVAE:0000348 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated fever AE 0.15 0.6 0.115 6 OVAE:0000349 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated drowsiness 0.15 0.6 0.115 6 OVAE:0000350 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated irritability AE 0.15 0.6 0.115 6 OVAE:0000351 A Infanrix vaccine adverse event that is associated with an administration of Infanrix and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM124514.pdf Infanrix-associated decreased appetite AE 0.3 0.115 6 OVAE:0000352 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Daptacel-associated injection-site tenderness AE 0.3 0.115 6 OVAE:0000353 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Daptacel-associated injection-site redness AE 0.3 0.115 6 OVAE:0000354 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Daptacel-associated injection-site edema AE 0.5 0.115 6 OVAE:0000355 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Daptacel-associated irritability AE 0.5 0.115 6 OVAE:0000356 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an inconsolable crying AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Daptacel-associated inconsolable crying AE 0.5 0.115 6 OVAE:0000357 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an lethargy AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Daptacel-associated lethargy AE 0.06 0.16 0.115 6 OVAE:0000358 A Daptacel vaccine adverse event that is associated with an administration of Daptacel and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM103037.pdf Daptacel-associated fever AE 0.25 0.115 6 OVAE:0000359 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Pediarix-associated injection-site pain AE 0.25 0.115 6 OVAE:0000360 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Pediarix-associated injection-site redness AE 0.25 0.115 6 OVAE:0000361 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Pediarix-associated local swelling AE 0.25 0.115 6 OVAE:0000362 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Pediarix-associated fever AE 0.25 0.115 6 OVAE:0000363 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Pediarix-associated drowsiness 0.25 0.115 6 OVAE:0000364 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Pediarix-associated irritability AE 0.25 0.115 6 OVAE:0000365 A Pediarix vaccine adverse event that is associated with an administration of Pediarix and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241874.pdf Pediarix-associated decreased appetite AE 0.5 4 6 OVAE:0000366 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Kinrix-associated injection-site pain AE 0.25 4 6 OVAE:0000367 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Kinrix-associated injection-site redness AE 0.25 4 6 OVAE:0000368 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Kinrix-associated injection-site edema AE 0.25 4 6 OVAE:0000369 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Kinrix-associated local swelling AE 0.15 4 6 OVAE:0000370 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Kinrix-associated drowsiness 0.15 4 6 OVAE:0000371 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Kinrix-associated fever AE 0.15 4 6 OVAE:0000372 A Kinrix vaccine adverse event that is associated with an administration of Kinrix and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM241453.pdf Kinrix-associated decreased appetite AE 0.5 0.115 4 OVAE:0000373 A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf Pentacel-associated irritability AE 0.5 0.115 4 OVAE:0000374 A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an inconsolable crying AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf Pentacel-associated inconsolable crying AE 0.06 0.16 0.115 4 OVAE:0000375 A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf Pentacel-associated fever AE 0.3 0.115 4 OVAE:0000376 A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf Pentacel-associated injection-site tenderness AE 0.3 0.115 4 OVAE:0000377 A Pentacel vaccine adverse event that is associated with an administration of Pentacel and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109810.pdf Pentacel-associated injection-site edema AE 1 1.25 OVAE:0000378 A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf ActHIB-associated injection-site pain AE 1 1.25 OVAE:0000379 A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf ActHIB-associated injection-site redness AE 1 1.25 OVAE:0000380 A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf ActHIB-associated local swelling AE 1 1.25 OVAE:0000381 A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf ActHIB-associated fever AE 1 1.25 OVAE:0000382 A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf ActHIB-associated irritability AE 1 1.25 OVAE:0000383 A ActHIB vaccine adverse event that is associated with an administration of ActHIB and displays an lethargy AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109841.pdf ActHIB-associated lethargy AE 0.2 1.25 4 OVAE:0000384 A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Hiberix-associated injection-site pain AE 0.2 1.25 4 OVAE:0000385 A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Hiberix-associated injection-site redness AE 0.2 1.25 4 OVAE:0000386 A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Hiberix-associated fever AE 0.2 1.25 4 OVAE:0000387 A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an fussiness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Hiberix-associated fussiness AE 0.2 1.25 4 OVAE:0000388 A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Hiberix-associated decreased appetite AE 0.2 1.25 4 OVAE:0000389 A Hiberix vaccine adverse event that is associated with an administration of Hiberix and displays an restlessness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM179530.pdf Hiberix-associated restlessness AE 0.01 0.17 0.5 OVAE:0000390 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated irritability AE 0.01 0.17 0.5 OVAE:0000391 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an sleepiness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated sleepiness AE 0.01 0.17 0.5 OVAE:0000392 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated injection-site pain AE 0.01 0.17 0.5 OVAE:0000393 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated injection-site erythema AE 0.01 0.17 0.5 OVAE:0000394 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated local swelling AE 0.01 0.17 0.5 OVAE:0000395 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated injection-site induration AE 0.01 0.17 0.5 OVAE:0000396 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an unusual high-patched crying AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated unusual high-patched crying AE 0.01 0.17 0.5 OVAE:0000397 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an prolonged crying AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated prolonged crying AE 0.01 0.17 0.5 OVAE:0000398 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated diarrhea AE 0.01 0.17 0.5 OVAE:0000399 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated vomiting AE 0.01 0.17 0.5 OVAE:0000400 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an crying abnormal AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated crying abnormal AE 0.01 0.17 0.5 OVAE:0000401 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated pain AE 0.01 0.17 0.5 OVAE:0000402 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an otitis media AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated otitis media AE 0.01 0.17 0.5 OVAE:0000403 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated rash AE 0.01 0.17 0.5 OVAE:0000404 A PedvaxHIB vaccine adverse event that is associated with an administration of PedvaxHIB and displays an upper respiratory tract infection AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM253652.pdf PedvaxHIB-associated upper respiratory tract infection AE 0.01 0.115 1.25 OVAE:0000405 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated injection-site pain AE 0.01 0.115 1.25 OVAE:0000406 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated injection-site tenderness AE 0.01 0.115 1.25 OVAE:0000407 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated injection-site soreness AE 0.01 0.115 1.25 OVAE:0000408 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated local swelling AE 0.01 0.115 1.25 OVAE:0000409 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated injection-site induration AE 0.01 0.115 1.25 OVAE:0000410 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated injection-site erythema AE 0.01 0.115 1.25 OVAE:0000411 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated fever AE 0.01 0.115 1.25 OVAE:0000412 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an anorexia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated anorexia AE 0.01 0.115 1.25 OVAE:0000413 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated diarrhea AE 0.01 0.115 1.25 OVAE:0000414 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated vomiting AE 0.01 0.115 1.25 OVAE:0000415 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated irritability AE 0.01 0.115 1.25 OVAE:0000416 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an somnolence AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated somnolence AE 0.01 0.115 1.25 OVAE:0000417 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an crying abnormal AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated crying abnormal AE 0.01 0.115 1.25 OVAE:0000418 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an upper respiratory tract infection AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated upper respiratory tract infection AE 0.01 0.115 1.25 OVAE:0000419 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an rhinorrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated rhinorrhea AE 0.01 0.115 1.25 OVAE:0000420 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an cough Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated cough 0.01 0.115 1.25 OVAE:0000421 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an rhinitis AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated rhinitis AE 0.01 0.115 1.25 OVAE:0000422 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated rash AE 0.01 0.115 1.25 OVAE:0000423 A Comvax vaccine adverse event that is associated with an administration of Comvax and displays an otitis media AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM109869.pdf Comvax-associated otitis media AE 18 0.23 2 18 0.21 OVAE:0000425 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated injection-site muscular soreness AE 0.9 2 18 OVAE:0000426 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated headache AE 18 0.14 OVAE:0000427 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated headache AE 0.92 2.08 0.32 OVAE:0000428 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated injection-site pain AE 0.92 2.08 0.29 OVAE:0000429 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated injection-site redness AE 0.92 2.08 0.42 OVAE:0000430 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated irritability AE 0.92 2.08 0.28 OVAE:0000431 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated drowsiness 0.92 2.08 0.28 OVAE:0000432 A Havrix vaccine adverse event that is associated with an administration of Havrix and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224555.pdf Havrix-associated decreased appetite AE 1 1.92 0.212 OVAE:0000434 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated injection-site erythema AE 1 1.92 0.164 OVAE:0000435 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated fever AE 1 1.92 0.37 19 0.67 2 18 0.187 OVAE:0000437 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated injection-site pain AE 19 0.67 OVAE:0000438 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated injection-site tenderness AE 19 0.67 OVAE:0000439 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated injection-site muscular soreness AE 19 0.182 OVAE:0000440 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an injection-site warmth AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated injection-site warmth AE 19 0.161 OVAE:0000441 A Vaqta vaccine adverse event that is associated with an administration of Vaqta and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110049.pdf Vaqta-associated headache AE 0.35 0.41 18 OVAE:0000442 A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110079.pdf Twinrix-associated injection-site muscular soreness AE 0.08 0.11 18 OVAE:0000443 A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110079.pdf Twinrix-associated injection-site redness AE 0.13 0.22 18 OVAE:0000444 A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110079.pdf Twinrix-associated headache AE 0.11 0.14 18 OVAE:0000445 A Twinrix vaccine adverse event that is associated with an administration of Twinrix and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110079.pdf Twinrix-associated fatigue AE 0 0.22 OVAE:0000446 A Engerix-B vaccine adverse event that is associated with an administration of Engerix-B and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224503.pdf Engerix-B-associated injection-site muscular soreness AE 0 0.14 OVAE:0000447 A Engerix-B vaccine adverse event that is associated with an administration of Engerix-B and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM224503.pdf Engerix-B-associated fatigue AE 0.01 0 OVAE:0000448 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated irritability AE 0.01 0 OVAE:0000449 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated fever AE 0.01 0 OVAE:0000450 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated diarrhea AE 0.01 0 OVAE:0000451 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated fatigue AE 0.01 0 OVAE:0000452 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated decreased appetite AE 0.01 0 OVAE:0000453 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an rhinitis AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated rhinitis AE 0.01 18 OVAE:0000454 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated injection-site muscular soreness AE 0.01 18 OVAE:0000455 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated injection-site pain AE 0.01 18 OVAE:0000456 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated injection-site tenderness AE 0.01 18 OVAE:0000457 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site pruritus AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated injection-site pruritus AE 0.01 18 OVAE:0000458 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated injection-site erythema AE 0.01 18 OVAE:0000459 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an ecchymosis AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated ecchymosis AE 0.01 18 OVAE:0000460 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated local swelling AE 0.01 18 OVAE:0000461 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an injection-site warmth AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated injection-site warmth AE 0.01 18 OVAE:0000462 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an skin nodule AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated skin nodule AE 0.01 18 OVAE:0000464 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated headache AE 0.01 18 OVAE:0000466 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated malaise AE 0.01 18 OVAE:0000467 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated nausea AE 0.01 18 OVAE:0000469 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an pharyngitis AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated pharyngitis AE 0.01 18 OVAE:0000470 A Recombivax HB vaccine adverse event that is associated with an administration of Recombivax HB and displays an upper respiratory tract infection AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM110114.pdf Recombivax HB-associated upper respiratory tract infection AE 9 26 OVAE:0000471 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated headache AE 0.01 9 26 OVAE:0000472 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated fever AE 0.01 9 26 OVAE:0000473 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated nausea AE 0.01 9 26 OVAE:0000474 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an dizziness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated dizziness AE 0.01 9 26 OVAE:0000475 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated injection-site pain AE 0.01 9 26 OVAE:0000476 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated local swelling AE 0.01 9 26 OVAE:0000477 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated injection-site erythema AE 0.01 9 26 OVAE:0000478 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an injection-site pruritus AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated injection-site pruritus AE 0.01 9 26 OVAE:0000479 A Gardasil vaccine adverse event that is associated with an administration of Gardasil and displays an hematoma, bruise, ecchymoses AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM111263.pdf Gardasil-associated hematoma, bruise, ecchymoses AE 0.2 9 25 OVAE:0000480 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated injection-site pain AE 0.2 9 25 OVAE:0000481 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated injection-site redness AE 0.2 9 25 OVAE:0000482 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated local swelling AE 0.2 9 25 OVAE:0000483 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated fatigue AE 0.2 9 25 OVAE:0000484 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated headache AE 0.2 9 25 OVAE:0000485 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated myalgia AE 0.2 9 25 OVAE:0000486 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an gastrointestinal disorder AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated gastrointestinal disorder AE 0.2 9 25 OVAE:0000487 A Cervarix vaccine adverse event that is associated with an administration of Cervarix and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM186981.pdf Cervarix-associated arthralgia AE 0.1 17 OVAE:0000488 A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142570.pdf Ixiaro-associated injection-site pain AE 0.1 17 OVAE:0000489 A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142570.pdf Ixiaro-associated injection-site tenderness AE 0.1 17 OVAE:0000490 A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142570.pdf Ixiaro-associated headache AE 0.1 17 OVAE:0000491 A Ixiaro vaccine adverse event that is associated with an administration of Ixiaro and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142570.pdf Ixiaro-associated myalgia AE 1 0.2 OVAE:0000492 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated injection-site tenderness AE 1 0.2 OVAE:0000493 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated injection-site redness AE 1 0.2 OVAE:0000494 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated local swelling AE 1 0.1 OVAE:0000495 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated fever AE 1 0.1 OVAE:0000496 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated headache AE 1 0.1 OVAE:0000497 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated malaise AE 1 0.1 OVAE:0000498 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated rash AE 1 0.1 OVAE:0000499 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an chills AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated chills AE 1 0.1 OVAE:0000500 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an dizziness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated dizziness AE 1 0.1 OVAE:0000501 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated myalgia AE 1 0.1 OVAE:0000502 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated nausea AE 1 0.1 OVAE:0000503 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated vomiting AE 1 0.1 OVAE:0000504 A JE-Vax vaccine adverse event that is associated with an administration of JE-Vax and displays an abdominal pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123761.pdf JE-Vax-associated abdominal pain AE 0.05 1 12 OVAE:0000505 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated injection-site pain AE 0.05 1 12 OVAE:0000506 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated injection-site tenderness AE 0.05 1 12 OVAE:0000507 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated injection-site muscular soreness AE 0.05 1 12 OVAE:0000508 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated injection-site erythema AE 0.05 1 12 OVAE:0000509 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated local swelling AE 0.05 1 12 OVAE:0000510 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated fever AE 0.05 1 12 OVAE:0000511 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated irritability AE 0.05 1 12 OVAE:0000512 A ProQuad vaccine adverse event that is associated with an administration of ProQuad and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123793.pdf ProQuad-associated rash AE 2 10 0.23 OVAE:0000514 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated injection-site erythema AE 2 10 0.18 OVAE:0000515 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated irritability AE 2 10 0.16 OVAE:0000516 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated injection-site induration AE 2 10 0.14 OVAE:0000517 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an sleepiness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated sleepiness AE 13 55 0.41 2 10 0.31 OVAE:0000520 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated injection-site pain AE 13 55 0.3 2 10 0.11 OVAE:0000521 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated headache AE 13 55 0.13 OVAE:0000522 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated myalgia AE 13 55 0.16 2 10 0.12 OVAE:0000523 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated malaise AE 13 55 0.1 OVAE:0000524 A Menveo vaccine adverse event that is associated with an administration of Menveo and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201349.pdf Menveo-associated nausea AE 0.15 0.46 0.115 1.5 OVAE:0000525 A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf MenHibrix-associated injection-site pain AE 0.15 0.46 0.115 1.5 OVAE:0000526 A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf MenHibrix-associated injection-site redness AE 0.15 0.46 0.115 1.5 OVAE:0000527 A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf MenHibrix-associated local swelling AE 0.62 0.71 0.115 1.5 OVAE:0000528 A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf MenHibrix-associated irritability AE 0.49 0.63 0.115 1.5 OVAE:0000529 A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf MenHibrix-associated drowsiness 0.3 0.34 0.115 1.5 OVAE:0000530 A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf MenHibrix-associated decreased appetite AE 0.11 0.26 0.115 1.5 OVAE:0000531 A MenHibrix vaccine adverse event that is associated with an administration of MenHibrix and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308577.pdf MenHibrix-associated fever AE 0.01 0.75 1 OVAE:0000532 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated injection-site tenderness AE 0.01 0.75 1 OVAE:0000533 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated injection-site erythema AE 0.01 0.75 1 0.01 2 55 OVAE:0000534 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated local swelling AE 0.01 0.75 1 0.01 2 10 OVAE:0000535 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated irritability AE 0.01 0.75 1 OVAE:0000536 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an crying abnormal AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated crying abnormal AE 0.01 0.75 1 0.01 2 10 OVAE:0000537 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated drowsiness 0.01 0.75 1 OVAE:0000538 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated decreased appetite AE 0.01 0.75 1 OVAE:0000539 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated vomiting AE 0.01 0.75 1 OVAE:0000540 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated fever AE 0.01 2 55 OVAE:0000541 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated injection-site pain AE 0.01 2 55 OVAE:0000542 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated injection-site redness AE 0.01 2 55 OVAE:0000543 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated injection-site induration AE 0.01 2 55 OVAE:0000545 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an anorexia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated anorexia AE 0.01 2 55 OVAE:0000546 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated diarrhea AE 0.01 11 55 OVAE:0000549 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated headache AE 0.01 11 55 OVAE:0000550 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated fatigue AE 0.01 11 55 OVAE:0000551 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated malaise AE 0.01 11 55 OVAE:0000552 A Menactra vaccine adverse event that is associated with an administration of Menactra and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM131170.pdf Menactra-associated arthralgia AE 0.1 2 10 OVAE:0000553 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated injection-site pain AE 0.1 2 10 OVAE:0000554 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an drowsiness Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated drowsiness 0.1 2 10 OVAE:0000555 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated irritability AE 0.1 11 55 OVAE:0000556 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated diarrhea AE 0.1 11 55 OVAE:0000557 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated injection-site pain AE 0.1 11 55 OVAE:0000558 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated injection-site redness AE 0.1 11 55 OVAE:0000559 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated injection-site induration AE 0.1 11 55 OVAE:0000560 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated headache AE 0.1 11 55 OVAE:0000561 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated fatigue AE 0.1 11 55 OVAE:0000562 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated malaise AE 0.1 11 55 OVAE:0000563 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated arthralgia AE 0.1 11 55 OVAE:0000564 A Menomune-A/C/Y/W-135 vaccine adverse event that is associated with an administration of Menomune-A/C/Y/W-135 and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM308370.pdf Menomune-A/C/Y/W-135-associated diarrhea AE 50 0.6 OVAE:0000565 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated injection-site pain AE 50 0.6 OVAE:0000566 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site muscular soreness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated injection-site muscular soreness AE 50 0.6 OVAE:0000567 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated injection-site tenderness AE 50 0.203 OVAE:0000568 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated local swelling AE 50 0.203 OVAE:0000569 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated injection-site induration AE 50 0.164 OVAE:0000570 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated injection-site erythema AE 50 0.176 OVAE:0000571 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated headache AE 50 0.132 OVAE:0000572 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an asthenia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated asthenia AE 50 0.132 OVAE:0000573 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated fatigue AE 50 0.119 OVAE:0000574 A Pneumovax 23 vaccine adverse event that is associated with an administration of Pneumovax 23 and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM257088.pdf Pneumovax 23-associated myalgia AE 0.58 9 0.1723 OVAE:0000575 A Prevnar vaccine adverse event that is associated with an administration of Prevnar and displays an injection-site erythema AE Yongqun He, Erica Marcos Prevnar-associated injection-site erythema AE 0.58 9 0.15 OVAE:0000576 A Prevnar vaccine adverse event that is associated with an administration of Prevnar and displays an injection-site induration AE Yongqun He, Erica Marcos Prevnar-associated injection-site induration AE 0.58 9 0.29 OVAE:0000577 A Prevnar vaccine adverse event that is associated with an administration of Prevnar and displays an injection-site tenderness AE Yongqun He, Erica Marcos Prevnar-associated injection-site tenderness AE 0.5 0.17 1.25 OVAE:0000578 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated injection-site tenderness AE 0.1 50 0.2 0.17 1.25 OVAE:0000579 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated injection-site redness AE 0.1 50 0.2 0.17 1.25 OVAE:0000580 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated local swelling AE 0.1 50 0.4 0.17 1.25 OVAE:0000581 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated decreased appetite AE 0.4 0.17 1.25 OVAE:0000582 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an decreased sleep AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated decreased sleep AE 0.4 0.17 1.25 OVAE:0000583 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an increased sleep AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated increased sleep AE 0.2 0.17 1.25 OVAE:0000584 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated fever AE 0.7 0.17 1.25 OVAE:0000585 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated irritability AE 0.5 50 OVAE:0000586 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated injection-site pain AE 0.3 50 OVAE:0000589 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated fatigue AE 0.2 50 OVAE:0000590 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated headache AE 0.2 50 OVAE:0000591 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an muscle pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated muscle pain AE 0.1 50 OVAE:0000592 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an joint pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated joint pain AE 0.1 50 OVAE:0000594 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an arm motion limitation AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated arm motion limitation AE 0.05 50 OVAE:0000595 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an chills AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated chills AE 0.05 50 OVAE:0000596 A Prevnar 13 vaccine adverse event that is associated with an administration of Prevnar 13 and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM201669.pdf Prevnar 13-associated rash AE 0.17 1.5 0.32 OVAE:0000597 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated injection-site erythema AE 0.17 1.5 0.01 OVAE:0000598 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated injection-site induration AE 0.17 1.5 0.13 OVAE:0000599 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated injection-site pain AE 0.17 1.5 0.38 OVAE:0000600 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated fever AE 0.17 1.5 OVAE:0000601 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated irritability AE 0.17 1.5 OVAE:0000602 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an sleepiness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated sleepiness AE 0.17 1.5 OVAE:0000603 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an fussiness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated fussiness AE 0.17 1.5 OVAE:0000604 A IPOL vaccine adverse event that is associated with an administration of IPOL and displays an crying abnormal AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133479.pdf IPOL-associated crying abnormal AE 0 0.25 OVAE:0000605 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated injection-site pain AE 0 0.25 OVAE:0000606 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated injection-site erythema AE 0 0.25 OVAE:0000607 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated local swelling AE 0 0.25 OVAE:0000608 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an itching Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated itching 0 0.2 OVAE:0000609 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated headache AE 0 0.2 OVAE:0000610 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated nausea AE 0 0.2 OVAE:0000611 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an abdominal pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated abdominal pain AE 0 0.2 OVAE:0000612 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an muscle ache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated muscle ache AE 0 0.2 OVAE:0000613 A Imovax Rabies vaccine adverse event that is associated with an administration of Imovax Rabies and displays an dizziness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133484.pdf Imovax Rabies-associated dizziness AE 0 OVAE:0000614 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated injection-site erythema AE 0 OVAE:0000615 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated injection-site induration AE 0 OVAE:0000616 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated injection-site pain AE 0 OVAE:0000617 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an asthenia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated asthenia AE 0 OVAE:0000618 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated fatigue AE 0 OVAE:0000619 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated fever AE 0 OVAE:0000620 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated headache AE 0 OVAE:0000621 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated myalgia AE 0 OVAE:0000622 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated malaise AE 0 OVAE:0000623 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated arthralgia AE 0 OVAE:0000624 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an dizziness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated dizziness AE 0 OVAE:0000625 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an lymphadenopathy AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated lymphadenopathy AE 0 OVAE:0000626 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated nausea AE 0 OVAE:0000627 A RabAvert vaccine adverse event that is associated with an administration of RabAvert and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM312931.pdf RabAvert-associated rash AE 0.05 0.115 0.46 OVAE:0000628 A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Rotarix-associated irritability AE 0.05 0.115 0.46 OVAE:0000629 A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an cough Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Rotarix-associated cough 0.05 0.115 0.46 OVAE:0000630 A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an runny nose Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Rotarix-associated runny nose 0.05 0.115 0.46 OVAE:0000631 A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Rotarix-associated fever AE 0.05 0.115 0.46 OVAE:0000632 A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an decreased appetite AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Rotarix-associated decreased appetite AE 0.05 0.115 0.46 OVAE:0000633 A Rotarix vaccine adverse event that is associated with an administration of Rotarix and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM133539.pdf Rotarix-associated vomiting AE 0.115 0.62 OVAE:0000634 A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf RotaTeq-associated diarrhea AE 0.115 0.62 OVAE:0000635 A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf RotaTeq-associated vomiting AE 0.115 0.62 OVAE:0000636 A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf RotaTeq-associated irritability AE 0.115 0.62 OVAE:0000637 A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an otitis media AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf RotaTeq-associated otitis media AE 0.115 0.62 OVAE:0000638 A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an nasopharyngitis AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf RotaTeq-associated nasopharyngitis AE 0.115 0.62 OVAE:0000639 A RotaTeq vaccine adverse event that is associated with an administration of RotaTeq and displays an bronchospasm AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142288.pdf RotaTeq-associated bronchospasm AE 1 OVAE:0000640 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated fever AE 1 OVAE:0000641 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an syncope AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated syncope AE 1 OVAE:0000642 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated headache AE 1 OVAE:0000643 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an dizziness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated dizziness AE 1 OVAE:0000644 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated malaise AE 1 OVAE:0000645 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated irritability AE 1 OVAE:0000646 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an vasculitis AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated vasculitis AE 1 OVAE:0000647 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated diarrhea AE 1 OVAE:0000648 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated vomiting AE 1 OVAE:0000649 A Meruvax II vaccine adverse event that is associated with an administration of Meruvax II and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142553.pdf Meruvax II-associated nausea AE 0 OVAE:0000650 A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an lymphadenitis AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf ACAM2000-associated lymphadenitis AE 0 OVAE:0000651 A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf ACAM2000-associated malaise AE 0 OVAE:0000652 A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf ACAM2000-associated fatigue AE 0 OVAE:0000653 A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf ACAM2000-associated fever AE 0 OVAE:0000654 A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf ACAM2000-associated myalgia AE 0 OVAE:0000655 A ACAM2000 vaccine adverse event that is associated with an administration of ACAM2000 and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142572.pdf ACAM2000-associated headache AE 7 OVAE:0000656 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated injection-site pain AE 7 OVAE:0000657 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated injection-site tenderness AE 7 OVAE:0000658 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated injection-site erythema AE 7 OVAE:0000659 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated injection-site induration AE 7 OVAE:0000660 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an injection-site pruritus AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated injection-site pruritus AE 7 OVAE:0000661 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated local swelling AE 7 OVAE:0000662 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an oedema, swelling dropsy Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated oedema, swelling dropsy 7 OVAE:0000663 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an pyrexia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated pyrexia AE 7 OVAE:0000664 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated malaise AE 7 OVAE:0000665 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an dizziness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated dizziness AE 7 OVAE:0000666 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated headache AE 7 OVAE:0000667 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an convulsion AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated convulsion AE 7 OVAE:0000668 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated myalgia AE 7 OVAE:0000669 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an musculoskeletal stiffness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated musculoskeletal stiffness AE 7 OVAE:0000670 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an musculoskeletal pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated musculoskeletal pain AE 7 OVAE:0000671 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated arthralgia AE 7 OVAE:0000672 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated rash AE 7 OVAE:0000673 A adverse event associated with Tetanus and Diptheria Toxoids Absorbed by MA Biological that is associated with an administration of Tetanus and Diptheria Toxoids Absorbed and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM164127.pdf Tetanus and Diptheria Toxoids Absorbed-associated nausea AE 11 17 0.71 18 64 0.63 OVAE:0000675 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated injection-site pain AE 11 17 0.4 18 64 0.34 OVAE:0000677 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated headache AE 0.1 11 64 OVAE:0000678 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated local swelling AE 0.1 11 64 OVAE:0000679 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated injection-site erythema AE 0.1 11 64 OVAE:0000680 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated pain AE 0.1 11 64 OVAE:0000681 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an muscular weakness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated muscular weakness AE 0.1 11 64 OVAE:0000682 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an tiredness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated tiredness AE 0.1 11 64 OVAE:0000683 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated diarrhea AE 0.1 11 17 OVAE:0000684 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an chills AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated chills AE 0.1 11 17 OVAE:0000685 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated nausea AE 0.1 11 17 OVAE:0000686 A Decavac vaccine adverse event that is associated with an administration of Decavac and displays an joint swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM246215.pdf Decavac-associated joint swelling AE 11 59 0.783 60 0.353 OVAE:0000687 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated injection-site pain AE 7 0.179 OVAE:0000689 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated headache AE 0.1 7 OVAE:0000690 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated injection-site redness AE 0.1 7 OVAE:0000691 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated local swelling AE 0.1 7 OVAE:0000692 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated malaise AE 0.1 7 OVAE:0000693 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an muscular weakness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated muscular weakness AE 0.1 7 OVAE:0000694 A Tenivac vaccine adverse event that is associated with an administration of Tenivac and displays an joint pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152826.pdf Tenivac-associated joint pain AE 7 OVAE:0000695 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated injection-site redness AE 7 OVAE:0000696 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site warmth AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated injection-site warmth AE 7 OVAE:0000697 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated injection-site edema AE 7 OVAE:0000698 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated injection-site induration AE 7 OVAE:0000699 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an induration with tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated induration with tenderness AE 7 OVAE:0000700 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an urticaria AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated urticaria AE 7 OVAE:0000701 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated rash AE 7 OVAE:0000702 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated malaise AE 7 OVAE:0000703 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated fever AE 7 OVAE:0000704 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated pain AE 7 OVAE:0000705 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an hypotension AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated hypotension AE 7 OVAE:0000706 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated nausea AE OVAE:0000707 A Tetanus Toxoid (boost only) vaccine adverse event that is associated with an administration of Tetanus Toxoid and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf Tetanus Toxoid-associated arthralgia AE 7 OVAE:0000708 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated injection-site redness AE 7 OVAE:0000709 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site warmth AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated injection-site warmth AE 7 OVAE:0000710 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated injection-site edema AE 7 OVAE:0000711 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated injection-site induration AE 7 OVAE:0000712 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an induration with tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated induration with tenderness AE 7 OVAE:0000713 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an urticaria AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated urticaria AE 7 OVAE:0000714 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated rash AE 7 OVAE:0000715 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated malaise AE 7 OVAE:0000716 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated fever AE 7 OVAE:0000717 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated pain AE 7 OVAE:0000718 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an hypotension AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated hypotension AE 7 OVAE:0000719 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated nausea AE 7 OVAE:0000720 A Tetanus Toxoid Absorbed vaccine adverse event that is associated with an administration of Tetanus Toxoid Absorbed and displays an arthralgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid Absorbed-associated arthralgia AE 11 17 0.778 18 64 0.657 OVAE:0000724 A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Adacel-associated injection-site pain AE 11 17 0.209 18 64 0.21 OVAE:0000725 A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Adacel-associated local swelling AE 11 17 0.208 18 64 0.247 OVAE:0000726 A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Adacel-associated injection-site erythema AE 11 17 0.151 OVAE:0000729 A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Adacel-associated fatigue AE 11 17 0.437 18 64 0.339 OVAE:0000730 A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Adacel-associated headache AE 11 17 0.304 18 0.219 OVAE:0000731 A Adacel vaccine adverse event that is associated with an administration of Adacel and displays an muscular weakness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142764.pdf Adacel-associated muscular weakness AE 0.15 10 18 0.15 19 64 0.15 65 OVAE:0000732 A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated injection-site pain AE 0.15 10 18 0.15 19 64 OVAE:0000733 A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an injection-site redness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated injection-site redness AE 0.15 10 18 0.15 19 64 OVAE:0000734 A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an local swelling AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated local swelling AE 0.15 10 18 OVAE:0000735 A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated injection-site edema AE 0.15 10 18 0.15 19 64 OVAE:0000736 A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated headache AE 0.15 10 18 0.15 19 64 OVAE:0000737 A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an fatigue AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated fatigue AE 0.15 10 18 0.15 19 64 OVAE:0000738 A Boostrix vaccine adverse event that is associated with an administration of Boostrix and displays an gastrointestinal disorder AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/UCM152842.pdf Boostrix-associated gastrointestinal disorder AE OVAE:0000746 A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an abdominal pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Vivotif-associated abdominal pain AE 6 0.058 OVAE:0000747 A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Vivotif-associated nausea AE 6 0.048 OVAE:0000748 A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Vivotif-associated headache AE 6 0.033 OVAE:0000749 A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Vivotif-associated fever AE 6 0.029 OVAE:0000750 A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Vivotif-associated diarrhea AE 6 0.015 OVAE:0000751 A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Vivotif-associated vomiting AE 6 0.01 OVAE:0000752 A Vivotif vaccine adverse event that is associated with an administration of Vivotif and displays an rash AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf Vivotif-associated rash AE 18 40 0.975 OVAE:0000753 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site tenderness AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated injection-site tenderness AE 18 40 0.336 OVAE:0000754 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated injection-site pain AE 18 40 0.0995 OVAE:0000755 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site induration AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated injection-site induration AE 18 40 0.044 OVAE:0000756 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an injection-site erythema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated injection-site erythema AE 18 40 0.1405 OVAE:0000757 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an malaise AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated malaise AE 18 40 0.1225 OVAE:0000758 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated headache AE 18 40 0.00525 OVAE:0000759 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated myalgia AE 18 40 0.00505 OVAE:0000760 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an nausea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated nausea AE 18 40 0.0155 OVAE:0000761 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an diarrhea AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated diarrhea AE 18 40 0.071 OVAE:0000762 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an irritability AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated irritability AE 18 40 0.0095 OVAE:0000763 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated fever AE 18 40 0.0095 OVAE:0000764 A Typhim Vi vaccine adverse event that is associated with an administration of Typhim Vi and displays an vomiting AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142811.pdf Typhim Vi-associated vomiting AE 1 12 0.147 13 0.102 OVAE:0000765 A Varivax vaccine adverse event that is associated with an administration of Varivax and displays an fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142813.pdf Varivax-associated fever AE 1 12 0.193 13 0.244 OVAE:0000766 A Varivax vaccine adverse event that is associated with an administration of Varivax and displays an injection-site adverse event Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142813.pdf Varivax-associated injection-site adverse event 0.75 OVAE:0000769 A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf YF-Vax-associated headache AE 0.75 OVAE:0000770 A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an myalgia AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf YF-Vax-associated myalgia AE 0.75 OVAE:0000771 A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an low grade fever AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf YF-Vax-associated low grade fever AE 0.75 OVAE:0000772 A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an injection-site edema AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf YF-Vax-associated injection-site edema AE 0.75 OVAE:0000773 A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an hypersensitivity AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf YF-Vax-associated hypersensitivity AE 0.75 OVAE:0000774 A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an injection-site pain AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf YF-Vax-associated injection-site pain AE 0.75 OVAE:0000775 A YF-Vax vaccine adverse event that is associated with an administration of YF-Vax and displays an injection-site mass AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142831.pdf YF-Vax-associated injection-site mass AE 0.01 50 OVAE:0000776 A Zostavax vaccine adverse event that is associated with an administration of Zostavax and displays an headache AE Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM132831.pdf Zostavax-associated headache AE 0.01 50 OVAE:0000777 A Zostavax vaccine adverse event that is associated with an administration of Zostavax and displays an injection-site reaction Yongqun He, Erica Marcos WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM132831.pdf Zostavax-associated injection-site reaction OVAE:0000984 An influenza vaccine adverse event that is associated with the administration of Afluria. Yongqun He Afluria vaccine adverse event OVAE:0000985 An influenza vaccine adverse event that is associated with the administration of FluMist. Yongqun He FluMist vaccine adverse event OVAE:0000986 Yongqun He ActHIB vaccine adverse event OVAE:0000987 A smallpox vaccine adverse event that is associated with the administration of ACAM2000. Yongqun He, Erica Marcos ACAM2000 vaccine adverse event OVAE:0000988 Yongqun He Adacel vaccine adverse event PATO:0000165 time A quality in which events occur in sequence. time PATO:0000169 viability An organismal quality inhering in a bearer or a population by virtue of the bearer's ability or inability to survive and develop normally or the number of surviving individuals in a given population. viability An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation. PATO:0001722 behavioural quality quality PATO:0000186 behavioral quality PATO:0000186 PATO:0001018 physical quality A quality of a single physical entity that exists through action of continuants at the physical level of organisation. physical quality A quality which inheres in an process. PATO:0001239 PATO:0001240 quality of a process quality of occurrent quality of process relational quality of occurrent quality PATO:0001236 See comments of relational quality of a physical entity. process quality PATO:0001236 PATO:0001237 quality of a single physical entity A physical object quality which inheres in a single-bearer. quality of a single physical entity physical object quality A quality which inheres in a continuant. A quality which inheres in a continuant. PATO:0001237 PATO:0001238 snap:Quality monadic quality of a continuant multiply inhering quality of a physical entity quality of a continuant quality of a single physical entity quality of an object quality of continuant monadic quality of an object monadic quality of continuant quality PATO:0001241 Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. physical object quality physical object quality PATO:0001241 organismal quality A quality that inheres in an entire organism or part of an organism. A quality that inheres in an entire organism or part of an organism. quality PATO:0001995 organismal quality organismal quality PATO:0001995 PATO:0002146 virulence A quality inhering in a bearer by virtue of the bearer's pathogenicity. virulence The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity. Organ that is the specialized structure of the face that contains olfactory neurons. The peripheral olfactory organ is paired[ZFA:0000047]. a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the digestive system, and then into the rest of the respiratory system. In humans, the nose is located centrally on the face; on most other mammals, it is on the upper tip of the snout[WP]. GO: The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)[Wikipedia:Nose]. the organ that is specialized for smell and is part of the respiratory system the structure of the nose varies across vertebrates. In tetrapods the nose is part of the respiratory system.[PMID:25312359] BTO:0000840 CALOHA:TS-2037 EHDAA2:0001274 EHDAA:1502 EMAPA:16542 EV:0100037 EV:0100370 FMA:46472 GAID:77 MA:0000281 MAT:0000139 MESH:D009666 MIAA:0000139 OpenCyc:Mx4rvViCbJwpEbGdrcN5Y29ycA TAO:0000047 UMLS:C0028429 ZFA:0000047 galen:Nose nasal sac nose peripheral olfactory organ uberon nasus olfactory apparatus proboscis UBERON:0000004 nose UBERON:0000004 A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO] Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO] The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO) (...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG] AAO:0000429 BAMS:PNS BILA:0000081 BTO:0001028 CALOHA:TS-0808 EFO:0000891 EHDAA2:0001445 EHDAA:2893 EMAPA:16665 EV:0100335 FBbt:00005098 FMA:9903 GAID:715 MA:0000218 MAT:0000338 MESH:D017933 MIAA:0000338 TAO:0000142 UMLS:C0206417 UMLS:C1305921 VHOG:0000399 XAO:0000178 ZFA:0000142 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=247 pars peripherica systema nervosum periphericum uberon PNS lateral part of the basal amygdalar nucleus lateral part of the basolateral nucleus nucleus amygdalae basalis, pars lateralis nucleus amygdaloideus basalis, pars lateralis magnocellularis nucleus basalis lateralis amygdalae pars peripherica; systema nervosum periphericum UBERON:0000010 peripheral nervous system UBERON:0000010 Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee (...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG] we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive EHDAA2:0001844 EHDAA:6530 EMAPA:17525 EV:0100152 FMA:86166 GAID:933 MA:0000151 MAT:0000284 MESH:D012867 MIAA:0000284 OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA VHOG:0000860 portion of skin region of skin skin skin region skin zone uberon UBERON:0000014 zone of skin UBERON:0000014 A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. AEO:0000192 CARO:0000010 FMA:50705 uberon UBERON:0000015 Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. anatomical boundary UBERON:0000015 An organ that is capable of transducing sensory stimulus to the nervous system. AEO:0000094 BSA:0000121 BTO:0000202 CALOHA:TS-2043 EHDAA2:0001824 EHDAA:500 EMAPA:16192 EMAPA:35955 FBbt:00005155 GAID:63 HAO:0000930 MA:0000017 MESH:D012679 UMLS:C0935626 VHOG:0001407 WBbt:0006929 organ of sense organ system organ of sensory organ system organ of sensory system sense organ system organ sensory organ sensory organ system organ sensory system organ sensillum uberon Sinnesorgan sensor UBERON:0000020 sense organ UBERON:0000020 Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts) tubular galen:Tube anatomical tube duct uberon UBERON:0000025 tube UBERON:0000025 Major subdivision of an organism that protrudes from the body[DOS, CARO]. An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs[BILA][BILA:0000018]. Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736]. appendicular this is currently a subtype of organism subdivision - which would exclude feathers AEO:0000193 BILA:0000018 BTO:0001492 CARO:0010003 EFO:0000799 EHDAA2:0003193 EV:0100155 FBbt:00007000 HAO:0000144 MAT:0000023 MESH:D005121 MIAA:0000023 OpenCyc:Mx4rvViC-JwpEbGdrcN5Y29ycA UMLS:C0598782 VSAO:0000075 XAO:0000218 uberon appendages extremitaet extremity limbs/digits/tail UBERON:0000026 appendage UBERON:0000026 The head is the anterior-most division of the body [GO]. Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO] Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO] Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG] AAO:0010335 AEO:0000106 BILA:0000115 BTO:0000282 CALOHA:TS-0436 EFO:0000964 EHDAA2:0003106 EMAPA:31858 FBbt:00000004 FMA:7154 GAID:61 HAO:0000397 MA:0000023 MAT:0000294 MESH:D006257 MIAA:0000294 OpenCyc:Mx4rEOLm4rgPEdmAAAACs6hRjg OpenCyc:Mx4rvVi6YJwpEbGdrcN5Y29ycA SPD:0000016 TAO:0001114 TGMA:0000002 UMLS:C0018670 VHOG:0001644 WBbt:0005739 XAO:0003024 ZFA:0001114 galen:Head head (volume) adult head uberon cephalic area UBERON:0000033 head UBERON:0000033 multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO] a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP] in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA. FMA:9581 GAID:19 MESH:D012704 TAO:0005425 UMLS:C0036760 ZFA:0005425 tunica serosa wall of serous sac uberon serosa UBERON:0000042 serous membrane UBERON:0000042 Dense regular connective tissue that connects muscle to bone[VSAO]. Dense regular connective tissue that connects muscle to bone.[VSAO] Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG] in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis AEO:0000091 BTO:0001356 CALOHA:TS-1021 EHDAA2:0003091 EMAPA:35854 EV:0100149 FMA:9721 GAID:276 MA:0000115 MESH:D013710 OpenCyc:Mx4rvVjefJwpEbGdrcN5Y29ycA UMLS:C0039508 VHOG:0001286 VSAO:0000073 XAO:0000173 ZFA:0005647 galen:Tendon uberon sinew tendo UBERON:0000043 tendon UBERON:0000043 A biological tissue mass, most commonly a mass of nerve cell bodies. TODO - check vert vs invert. Other species: Any of a number of aggregations of neurons, glial cells and their processes, surrounded by a glial cell and connective tissue sheath (plural: ganglia). // Subdivision of neural tree (organ) which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord); together with a nucleus and its associated nerve, it constitutes a neural tree (organ). Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion. // a cluster of nerve cells and associated glial cells (nuclear location) // Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system. A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO] Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO] Subdivision of nervous system which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord. Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion (adapted from Foundational Model of Anatomy)[NIFSTD:nlx_anat_100302]. Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG] ganglionic AAO:0010426 AEO:0000135 BAMS:G BTO:0000497 CALOHA:TS-0397 EFO:0000899 EHDAA2:0003135 EHDAA:2897 EHDAA:4662 EHDAA:5621 EHDAA:918 EMAPA:32846 EV:0100372 FBbt:00005137 FMA:5884 MA:0002406 MAT:0000207 MAT:0000343 MESH:D005724 MIAA:0000207 MIAA:0000343 TAO:0000190 TGMA:0001016 UMLS:C0017067 VHOG:0000156 WBbt:0005189 XAO:0000209 ZFA:0000190 uberon ganglia neural ganglion UBERON:0000045 ganglion UBERON:0000045 A tubular structure that contains, conveys body fluid, such as blood or lymph. uberon UBERON:0000055 vessel UBERON:0000055 A tubular structure that transports secreted or excreted substances. A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]. Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here. AAO:0011123 FBbt:00100314 FMA:30320 TAO:0005171 UMLS:C0687028 XAO:0004000 ZFA:0005171 galen:Duct anatomical duct exocrine duct exocrine gland duct uberon ducts UBERON:0000058 duct UBERON:0000058 Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. in FMA, serosa is a wall UBERON:0009915 wall EMAPA:25036 FMA:82482 galen:Wall wall of organ uberon organ wall UBERON:0000060 anatomical wall UBERON:0000060 Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. AAO:0010825 AEO:0000003 BILA:0000003 CARO:0000003 EHDAA2:0003003 EMAPA:0 FBbt:00007001 FMA:67135 GAID:781 HAO:0000003 MA:0003000 MESH:D000825 TAO:0000037 TGMA:0001823 VHOG:0001759 WBbt:0000100 XAO:0003000 ZFA:0000037 biological structure connected biological structure uberon UBERON:0000061 anatomical structure UBERON:0000061 Anatomical structure that performs a specific function or group of functions [WP]. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4 CARO:0020004 EFO:0000634 EMAPA:35949 ENVO:01000162 FMA:67498 MA:0003001 OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA UMLS:C0178784 WBbt:0003760 uberon anatomical unit body organ element UBERON:0000062 organ UBERON:0000062 A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball. Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal. FMA:86140 uberon organ region with fixed fiat boundary organ segment segment of organ UBERON:0000063 organ subunit UBERON:0000063 A multicellular structure that is a part of an organ. currently defined in a very broad sense, may be replaced by more specific classes in the future AAO:0011124 EFO:0000635 FMA:82472 cardinal organ part uberon regional part of organ UBERON:0000064 organ part UBERON:0000064 Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts EHDAA2:0001606 EHDAA:1568 EHDAA:2219 EMAPA:16737 FMA:265130 OpenCyc:Mx4rvvM--pwpEbGdrcN5Y29ycA VHOG:0000393 uberon UBERON:0000065 respiratory tract UBERON:0000065 The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. adult stage BTO:0001043 BilaDO:0000004 EFO:0001272 FBdv:00005369 WBls:0000041 XtroDO:0000084 fully formed animal stage juvenile-adult stage uberon UBERON:0000066 fully formed stage UBERON:0000066 A stage that is part of the embryo stage. embryonic stage part uberon UBERON:0000067 embryo stage part UBERON:0000067 A life cycle stage that starts with fertilization and ends with the fully formed embryo. BilaDO:0000002 EV:0300001 FBdv:00005289 FMA:72652 HsapDv:0000002 MmusDv:0000002 OGES:000000 OGES:000022 WBls:0000003 WBls:0000092 WBls:0000102 XAO:1000012 embryonic stage uberon embryogenesis UBERON:0000068 embryo stage UBERON:0000068 End of the life of an organism. ncit:Death is an outcome XAO:0000437 XtroDO:0000085 uberon death UBERON:0000071 death stage UBERON:0000071 An section of a respiratory tract. MA:0000434 has subclasses upper and lower, so it corresponds to a segment of the tract, rather than the tract as a whole EMAPA:16737 FMA:45660 MA:0000434 uberon respiratory tract subdivision of respiratory tract UBERON:0000072 proximo-distal subdivision of respiratory tract UBERON:0000072 Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. Melissa Haendel 2009-06-18T09:00:04Z UMLS:C1518256 part of nervous system uberon UBERON:0000073 regional part of nervous system UBERON:0000073 Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. UBERON:0010322 FMA:85544 UMLS:C1519343 galen:ComplexSkeletalStructure skeletal system subdivision uberon skeletal system part UBERON:0000075 subdivision of skeletal system UBERON:0000075 The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube) (or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis EHDAA2:0001968 EHDAA:1494 EHDAA:350 EHDAA:4784 EHDAA:4790 EHDAA:4796 EHDAA:7860 EMAPA:16096 FMA:87656 UMLS:C1515087 surface (external) ectoderm surface ectoderm uberon UBERON:0000076 external ectoderm UBERON:0000076 stage succeeding embryo, including mature structure In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997) BilaDO:0000003 OGES:000010 OGES:000014 OGES:000024 WBls:0000022 WBls:0000093 WBls:0000103 postembryonic stage post-hatching stage uberon postembryonic UBERON:0000092 post-embryonic stage UBERON:0000092 Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA] cjm 2009-07-30T05:19:13Z membrane FMA:7145 membrane of organ uberon UBERON:0000094 membrane organ UBERON:0000094 An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism. FBdv:00000000 HsapDv:0000001 MmusDv:0000001 OGES:000011 ncithesaurus:Life entire life cycle entire lifespan life lifespan uberon UBERON:0000104 life cycle UBERON:0000104 A spatiotemporal region encompassing some part of the life cycle of an organism. this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here the WBls class 'all stages' belongs here as it is the superclass of other WBls stages we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage BILS:0000105 EFO:0000399 FBdv:00007012 FMA:24120 HsapDv:0000000 MmusDv:0000000 OlatDv:0000010 PdumDv:0000090 WBls:0000002 XAO:1000000 ZFS:0000000 ZFS:0100000 ncithesaurus:Developmental_Stage developmental stage stage uberon UBERON:0000105 life cycle stage UBERON:0000105 A stage at which the organism is a single cell produced by means of sexual reproduction. As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG] BILS:0000106 BilaDO:0000005 EFO:0001322 EHDAA:27 EMAPA:16033 FBdv:00005288 PdumDv:0000100 VHOG:0000745 XAO:1000001 ZFS:0000001 1-cell stage fertilized egg stage one cell stage uberon fertilized egg stage one-cell stage zygote zygotum UBERON:0000106 zygote stage UBERON:0000106 The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. BILS:0000107 BilaDO:0000006 EFO:0001290 FBdv:00000054 MESH:A16.254.270 MmusDv:0000004 OGES:000015 OGES:000020 PdumDv:0000200 XAO:1000004 ZFS:0000046 uberon UBERON:0000107 cleavage stage UBERON:0000107 An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. consider adding a preceding stage 'morula stage' as part of cleavage BILS:0000108 BilaDO:0000007 EFO:0001282 HsapDv:0000006 MmusDv:0000007 OGES:000003 OGES:000016 OGES:000021 OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg WBls:0000005 XAO:1000003 ZFS:0000045 uberon UBERON:0000108 blastula stage UBERON:0000108 A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. BILS:0000109 BilaDO:0000008 EFO:0001296 FBdv:00005317 HsapDv:0000010 MmusDv:0000013 OGES:000004 OGES:000019 WBls:0000010 XAO:1000005 ZFS:0000047 uberon blastocystis trilaminaris stage trilaminar blastocyst stage trilaminar blastoderm stage trilaminar disk stage trilaminar germ stage trilaminar stage UBERON:0000109 gastrula stage UBERON:0000109 Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. BILS:0000110 BilaDO:0000009 HsapDv:0000012 MmusDv:0000017 XAO:1000006 uberon UBERON:0000110 neurula stage UBERON:0000110 A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. BILS:0000111 BilaDO:0000010 HsapDv:0000015 MmusDv:0000018 OGES:000005 OGES:000032 uberon segmentation stage UBERON:0000111 organogenesis stage UBERON:0000111 Structure derived from foregut that becomes a lung[GO]. clarify successors - include bronchi? BTO:0001643 EHDAA2:0004089 UMLS:C1514420 UMLS:C1514897 uberon gemma pulmonalis gemma respiratoria lung bud primary lung bud respiratory diverticulum UBERON:0000118 lung bud UBERON:0000118 A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. UBERON:0005163 CARO:0001001 FBbt:00005099 funiculus nerve fiber bundle neural fiber bundle uberon UBERON:0000122 neuron projection bundle UBERON:0000122 uberon UBERON:0000153 anterior region of body UBERON:0000153 uberon UBERON:0000154 posterior region of body UBERON:0000154 First portion of the digestive tract[WP]. The portion of the digestive that develops from the stomodeum The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO] Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG] oral some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips AAO:0010355 BTO:0001090 BTO:0004698 CALOHA:TS-1315 EFO:0000825 EHDAA2:0001326 EHDAA:542 EMAPA:16262 FBbt:00003126 FMA:49184 GAID:75 MA:0000341 MA:0002474 MAT:0000038 MESH:A.01.456.505.631 MESH:D009055 MIAA:0000038 OpenCyc:Mx4rvVidh5wpEbGdrcN5Y29ycA TADS:0000040 TAO:0000547 TAO:0000590 TGMA:0000131 VHOG:0000280 VHOG:0000812 XAO:0003029 ZFA:0000547 ZFA:0000590 galen:Mouth http://upload.wikimedia.org/wikipedia/commons/thumb/d/d4/Illu01_head_neck.jpg/200px-Illu01_head_neck.jpg adult mouth regio oralis adult mouth uberon cavital oralis cavitas oris cavum oris mouth cavity oral region oral vestibule rima oris stoma stomatodaeum trophic apparatus vestibule of mouth vestibulum oris UBERON:0000165 TODO - check fly mouthpart. note in uberon we distinguish between the mouth and the oral opening. the mouth is part of the digestive tract. TODO - check isa parent subdivision of head - is it a subdivision of the head or digestive tract mouth UBERON:0000165 1 1 1 1 The pair of anatomical structures comprised of a left lung and right lung. FMA:68877 OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA lungs lungs pair pulmones set of lungs uberon UBERON:0000170 pair of lungs UBERON:0000170 Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. EMAPA:17607 SPD:0000428 TGMA:0001247 apparatus respiratorius organ breathing organ organ of apparatus respiratorius organ of respiratory system respiratory organ respiratory system organ uberon gas exchange organ UBERON:0000171 respiration organ UBERON:0000171 A fluid that is composed of blood plasma and erythrocytes. This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid. A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO] Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO] relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG] AAO:0000046 BTO:0000089 CALOHA:TS-0079 EFO:0000296 EHDAA2:0000176 EHDAA:418 EMAPA:16332 ENVO:02000027 EV:0100047 FMA:9670 GAID:965 MA:0000059 MESH:D001769 MIAA:0000315 OpenCyc:Mx4rvVjI8JwpEbGdrcN5Y29ycA TAO:0000007 UMLS:C0005767 VHOG:0000224 XAO:0000124 ZFA:0000007 galen:Blood portion of blood vertebrate blood uberon whole blood UBERON:0000178 blood UBERON:0000178 Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. cjm 2009-04-08T04:38:19Z CARO:0000081 uberon blood or blood analog circulating fluid UBERON:0000179 haemolymphatic fluid UBERON:0000179 Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula UBERON:0007011 BILA:0000059 BTO:0000128 GAID:1294 MESH:A16.254.270.274 OGEM:000006 OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg blastula embryo uberon blastosphere UBERON:0000307 blastula UBERON:0000307 In anatomy, the throat is the anterior part of the neck, in front of the vertebral column. It consists of the pharynx and larynx. An important feature of the throat is the epiglottis, a flap which separates the esophagus from the trachea and prevents inhalation of food or drink. The throat contains various blood vessels, various pharyngeal muscles, the trachea (windpipe) and the esophagus. The hyoid bone and the clavicle are the only bones located in the throat of mammals. It is sometimes considered a synonym for fauces. [WP,unvetted]. gular The hyoid bone and the clavicle are the only bones located in the throat of mammals. BTO:0000828 FMA:228738 OpenCyc:Mx4rwQtO_JwpEbGdrcN5Y29ycA UMLS:C0230069 uberon gula UBERON:0000341 throat UBERON:0000341 The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77 Anatomical system that consists of the muscles of the body.[VSAO] we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA AAO:0000307 BILA:0000088 BTO:0001369 BTO:0001485 EFO:0000801 EMAPA:35578 FBbt:00005069 FMA:72954 MA:0002888 MAT:0000025 MIAA:0000025 VSAO:0000033 XAO:0004042 muscle system muscle system of body muscular system musculature system set of all muscles set of muscles of body vertebrate muscular system uberon muskelsystem UBERON:0000383 musculature of body UBERON:0000383 A gland in which the principal secretory cells are serous secreting cells. glands that secrete watery albuminous material that often contains enzymes[MP:0008052]. BTO:0001837 FMA:62889 uberon UBERON:0000409 serous gland UBERON:0000409 A portion of organism substance that is produced by exocrine glands. BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions UBERON:0006540 secretion AEO:0001005 BTO:0002977 BTO:0002979 EMAPA:36535 FMA:9675 MA:0002504 MESH:D012634 UMLS:C1516992 galen:Secretion exocrine gland fluid/secretion secreted substance uberon exocrine gland fluid exocrine gland fluid or secretion exocrine gland secretion external secretion UBERON:0000456 bodily secretion UBERON:0000456 Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. AAO:0010839 AEO:0000004 BILA:0000004 CALOHA:TS-2101 CARO:0000004 EHDAA2:0003004 EMAPA:35178 FBbt:00007019 FMA:9669 HAO:0000004 MA:0002450 SPD:0000008 TAO:0001487 TGMA:0001824 VHOG:0001726 XAO:0004001 ZFA:0001487 galen:BodySubstance body fluid or substance body substance organism substance portion of body substance portion of organism substance uberon UBERON:0000463 organism substance UBERON:0000463 Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. lumen space AAO:0010110 AEO:0000005 BILA:0000005 CARO:0000005 EHDAA2:0003005 FBbt:00007017 FMA:5897 HAO:0000005 TAO:0001668 TGMA:0001825 UMLS:C0524461 VHOG:0001728 XAO:0003190 ZFA:0001643 lumen space uberon anatomical spaces UBERON:0000464 anatomical space UBERON:0000464 Anatomical entity that has mass. AAO:0010264 AEO:0000006 BILA:0000006 CARO:0000006 EHDAA2:0003006 FBbt:00007016 FMA:67165 HAO:0000006 TAO:0001836 TGMA:0001826 VHOG:0001721 uberon UBERON:0000465 material anatomical entity UBERON:0000465 Anatomical entity that has no mass. AAO:0010265 AEO:0000007 BILA:0000007 CARO:0000007 EHDAA2:0003007 FBbt:00007015 FMA:67112 HAO:0000007 TAO:0001835 TGMA:0001827 VHOG:0001727 immaterial physical anatomical entity uberon UBERON:0000466 immaterial anatomical entity UBERON:0000466 Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. system AAO:0000007 AEO:0000011 BILA:0000011 BSA:0000049 CALOHA:TS-2088 CARO:0000011 EHDAA2:0003011 EHDAA:392 EMAPA:16103 EV:0100000 FBbt:00004856 FMA:7149 HAO:0000011 MA:0000003 OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ TAO:0001439 TGMA:0001831 UMLS:C0460002 VHOG:0001725 WBbt:0005746 WBbt:0005763 XAO:0003002 ZFA:0001439 galen:AnatomicalSystem body system connected anatomical system organ system uberon anatomical systems UBERON:0000467 anatomical system UBERON:0000467 Anatomical structure that is an individual member of a species and consists of more than one cell. TODO - split body and mc organism? body continues after death stage organismal AAO:0010026 AEO:0000191 BILA:0000012 BSA:0000038 BTO:0000042 CARO:0000012 EFO:0002906 EHDAA2:0003103 EHDAA2:0003191 EHDAA:1 EHDAA:9178 EMAPA:25765 EV:0100016 FBbt:00000001 FMA:256135 HAO:0000012 TADS:0000001 TAO:0001094 TGMA:0001832 VHOG:0000671 WBbt:0007833 XAO:0003004 ZFA:0001094 galen:Organism ncithesaurus:Whole_Organism multi-cellular organism organism whole organism animal uberon Koerper body whole body UBERON:0000468 multicellular organism UBERON:0000468 Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency AAO:0010053 AEO:0000032 BILA:0000032 CALOHA:TS-2084 CARO:0000032 EFO:0000808 EHDAA2:0003032 EMAPA:36031 FBbt:00007009 FMA:7153 HAO:0000032 MA:0002433 MAT:0000293 MESH:D001829 MIAA:0000293 OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA TAO:0001308 TGMA:0001840 UMLS:C0229962 VHOG:0001758 XAO:0003013 ZFA:0001308 galen:BodyPart anatomic region uberon body part body region cardinal body part UBERON:0000475 organism subdivision UBERON:0000475 Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. AAO:0010268 AEO:0000040 BILA:0000040 CARO:0000040 EHDAA2:0003040 FBbt:00007013 FMA:63863 HAO:0000040 TAO:0000382 TGMA:0001841 XAO:0003162 ZFA:0000382 uberon acellular anatomical structures UBERON:0000476 acellular anatomical structure UBERON:0000476 Anatomical group that has its parts adjacent to one another. Will be obsoleted in CARO v2 [https://github.com/obophenotype/caro/issues/3] AAO:0010009 AEO:0000041 BILA:0000041 CARO:0000041 EHDAA2:0003041 FBbt:00007277 FMA:49443 HAO:0000041 TADS:0000605 TAO:0001478 TGMA:0001842 VHOG:0001737 XAO:0003160 ZFA:0001478 uberon UBERON:0000477 anatomical cluster UBERON:0000477 Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. changed label and definition to reflect CARO2 AAO:0000607 AAO:0010054 AEO:0000043 BILA:0000043 CALOHA:TS-2090 CARO:0000043 EHDAA2:0003043 EMAPA:35868 FBbt:00007003 FMA:9637 HAO:0000043 MA:0003002 MESH:D014024 TAO:0001477 TGMA:0001844 UMLS:C0040300 VHOG:0001757 WBbt:0005729 XAO:0003040 ZFA:0001477 galen:Tissue portion of tissue tissue portion simple tissue uberon UBERON:0000479 tissue UBERON:0000479 Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. AAO:0010048 AEO:0000055 BILA:0000055 CARO:0000055 EHDAA2:0003055 FBbt:00007010 HAO:0000055 TAO:0001488 TGMA:0001847 VHOG:0001762 XAO:0003037 ZFA:0001488 uberon multi-tissue structures UBERON:0000481 multi-tissue structure UBERON:0000481 Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG] epithelial AAO:0000144 AAO:0010055 AEO:0000066 BILA:0000066 BTO:0000416 CALOHA:TS-0288 CARO:0000066 EHDAA2:0003066 EMAPA:32738 FBbt:00007005 FMA:9639 GAID:402 HAO:0000066 MA:0003060 MESH:D004848 TAO:0001486 UMLS:C0014609 VHOG:0000387 XAO:0003045 ZFA:0001486 epithelial tissue portion of epithelium uberon UBERON:0000483 epithelium UBERON:0000483 Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA] Epithelium that consists of more than one layer of epithelial cells.[CARO] AAO:0010059 AEO:0000069 BILA:0000069 BTO:0002074 CARO:0000069 EHDAA2:0003069 FMA:45562 HAO:0000069 TAO:0001494 UMLS:C0682575 XAO:0004006 ZFA:0001494 stratified epithelium uberon laminated epithelium UBERON:0000486 multilaminar epithelium UBERON:0000486 Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA] Unilaminar epithelium that consists of a single layer of squamous cells.[CARO] AAO:0010066 AEO:0000070 BILA:0000070 BTO:0002073 CARO:0000070 EHDAA2:0003070 FMA:45565 HAO:0000070 TAO:0001498 UMLS:C0836133 XAO:0004010 ZFA:0001498 epithelium simplex squamosum uberon simple squamous epithelia UBERON:0000487 simple squamous epithelium UBERON:0000487 Compound organ that contains one or more macroscopic anatomical spaces. this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future AAO:0010016 AEO:0000072 BILA:0000072 CARO:0000072 EHDAA2:0003072 FMA:55671 HAO:0000072 TAO:0001490 TGMA:0001857 VHOG:0001730 XAO:0003165 ZFA:0001490 cavitated organ uberon cavitated compound organs UBERON:0000489 cavitated compound organ UBERON:0000489 Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA] consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable Epithelium that consists of a single layer of epithelial cells.[CARO] AAO:0010062 AEO:0000073 BILA:0000073 BTO:0002073 CARO:0000073 EHDAA2:0003073 FMA:45561 HAO:0000073 TAO:0001495 UMLS:C0682574 XAO:0004007 ZFA:0001495 simple epithelium uberon unilaminar epithelia UBERON:0000490 unilaminar epithelium UBERON:0000490 Subdivision of trunk that lies between the head and the abdomen. note that we use the slightly verbose term 'thoracic segment of trunk' to avoid confusuon with insect thorax. todo - taxonomic constraints. Also, in FMA 'thorax' is a synonym for chest EMAPA:35862 FMA:259209 MA:0000022 thorax uberon anterior subdivision of trunk upper body upper trunk UBERON:0000915 thoracic segment of trunk UBERON:0000915 The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column. Vertebrate specific. In arthropods 'abdomen' is the most distal section of the body which lies behind the thorax or cephalothorax. If need be we can introduce some grouping class abdominal celiac BTO:0000020 CALOHA:TS-0001 EFO:0000968 EMAPA:35102 EV:0100011 FMA:9577 GAID:16 MA:0000029 MAT:0000298 MESH:A01.047 MIAA:0000298 OpenCyc:Mx4rvVjgyZwpEbGdrcN5Y29ycA galen:Abdomen abdominopelvic region abdominopelvis uberon adult abdomen belly celiac region UBERON:0000916 abdomen UBERON:0000916 Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. embryonic Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo AAO:0011035 AEO:0000169 BILA:0000056 BSA:0000039 BTO:0000379 CALOHA:TS-0229 EFO:0001367 EHDAA2:0000002 EHDAA2_RETIRED:0003236 EHDAA:38 EMAPA:16039 FBbt:00000052 FMA:69068 GAID:963 MAT:0000226 MESH:D004622 MIAA:0000019 OGEM:000001 OpenCyc:Mx4rwP1ceZwpEbGdrcN5Y29ycA UMLS:C0013935 VHOG:0001766 XAO:0000113 ZFA:0000103 embryonic organism uberon developing organism developmental tissue UBERON:0000922 embryo UBERON:0000922 A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] embryonic tissue AAO:0000480 BILA:0000035 BTO:0000556 EMAPA:36033 FBbt:00000110 FMA:69069 GAID:1303 MESH:A16.254.425 TAO:0001122 UMLS:C0920502 UMLS:C1708239 VHOG:0001223 XAO:0003011 ZFA:0001122 germinal layer primary germ layer uberon embryonic germ layer embryonic germ layers UBERON:0000923 Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] germ layer UBERON:0000923 Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] ectodermal AAO:0000137 BILA:0000036 BTO:0000315 CALOHA:TS-0216 EFO:0000414 EHDAA2:0000428 EMAPA:16069 EV:0100003 FBbt:00000111 FMA:69070 GAID:1304 MAT:0000155 MAT:0000173 MESH:A16.254.425.273 MIAA:0000173 TAO:0000016 UMLS:C0013574 VHOG:0000153 XAO:0000001 ZFA:0000016 embryonic ectoderm uberon UBERON:0000924 ectoderm UBERON:0000924 Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] endodermal AAO:0000139 BILA:0000038 BTO:0000800 CALOHA:TS-0273 EFO:0002545 EHDAA2:0000436 EMAPA:16062 EV:0100005 FBbt:00000125 FMA:69071 GAID:1305 MAT:0000175 MESH:A16.254.425.407 MIAA:0000175 TAO:0000017 UMLS:C0014144 VHOG:0000154 XAO:0000090 ZFA:0000017 uberon entoderm UBERON:0000925 endoderm UBERON:0000925 The middle germ layer of the embryo, between the endoderm and ectoderm. Primary germ layer that is the middle of the embryonic germ layers.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] mesodermal sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates UBERON:0003263 AAO:0000304 BILA:0000037 BTO:0000839 CALOHA:TS-0623 EFO:0001981 EHDAA2:0001128 EHDAA:124 EHDAA:160 EHDAA:168 EHDAA:183 EMAPA:16083 EV:0100006 FBbt:00000126 FMA:69072 GAID:522 MAT:0000174 MESH:A16.254.425.660 MIAA:0000174 TAO:0000041 UMLS:C0025485 VHOG:0000152 XAO:0000050 ZFA:0000041 uberon embryonic mesoderm entire mesoderm mesodermal mantle UBERON:0000926 mesoderm UBERON:0000926 Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO] the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx stomodeal This class groups together disparate structures as all being the anterior part of the early metazoan digestive tract and precursor of the mouth. However, the developmental processes vary, so this class may be split in future. E.g. in mammals it is a rostral depression surrounded by prominences. Outgrowth of the prominences produces a stomodeal cavity. stomodeal-hypophyseal primordium BTO:0004224 EHDAA2:0001929 EMAPA:16263 FBbt:00000439 FMA:295846 TAO:0001290 TGMA:0000135 UMLS:C1514977 XAO:0000269 ZFA:0001290 mouth primordium primitive oral cavity stomatodeum stomodaeum uberon mouth pit oral ectoderm oral pit UBERON:0000930 stomodeum UBERON:0000930 A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO] Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO] relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO] As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG] cardiac AAO:0010210 BILA:0000020 BTO:0000562 CALOHA:TS-0445 EFO:0000815 EHDAA2:0000738 EHDAA:420 EMAPA:16105 EV:0100018 FMA:7088 GAID:174 MA:0000072 MAT:0000036 MESH:D006321 MIAA:0000036 OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA TAO:0000114 UMLS:C0018787 VHOG:0000276 XAO:0000064 ZFA:0000114 galen:Heart chambered heart vertebrate heart branchial heart uberon Herz@de cardium UBERON:0000948 Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" http://dx.doi.org/10.1101/gad.1485706 heart UBERON:0000948 The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. requires review for applicability to invertebrate structures, e.g. synganglion Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO] Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO] The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO) (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] AAO:0010478 ABA:Brain BAMS:Br BAMS:Brain BILA:0000135 BTO:0000142 CALOHA:TS-0095 DHBA:10155 EFO:0000302 EHDAA2:0000183 EHDAA:2641 EHDAA:6485 EMAPA:16894 EV:0100164 FBbt:00005095 FMA:50801 GAID:571 HBA:4005 MA:0000168 MAT:0000098 MESH:D001921 MIAA:0000098 OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA PBA:3999 TAO:0000008 UMLS:C0006104 UMLS:C1269537 VHOG:0000157 XAO:0000010 ZFA:0000008 galen:Brain http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=21 uberon encephalon suprasegmental levels of nervous system suprasegmental structures synganglion the brain UBERON:0000955 brain UBERON:0000955 An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck. cervical AEO:0000108 BTO:0000420 CALOHA:TS-2045 EFO:0000967 EHDAA2:0003108 EMAPA:35587 FMA:7155 GAID:86 MA:0000024 MAT:0000297 MESH:D009333 MIAA:0000297 OpenCyc:Mx4rvVjLF5wpEbGdrcN5Y29ycA UMLS:C0027530 galen:Neck uberon collum neck (volume) UBERON:0000974 neck UBERON:0000974 Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO] Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO] articulation joint AEO:0000182 BTO:0001686 CALOHA:TS-2023 EFO:0000948 EMAPA:35456 FMA:7490 GAID:102 MA:0000319 MAT:0000188 MESH:D007596 MIAA:0000188 OpenCyc:Mx4rvVjjdpwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0003182 TAO:0000367 UMLS:C0022417 VHOG:0001276 VSAO:0000101 XAO:0000171 ZFA:0001596 galen:Joint uberon articular joint joints UBERON:0000982 skeletal joint UBERON:0000982 The outer epithelial layer of the skin that is superficial to the dermis. A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO] The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO] relationship loss: subclass external integument structures (AAO:0000961)[AAO] (...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG] epidermal Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes). epidermis skin AAO:0000143 BTO:0000404 CALOHA:TS-0283 EFO:0000954 EMAPA:17528 EV:0100153 FMA:70596 GAID:932 MA:0000153 MAT:0000154 MESH:D004817 MIAA:0000154 TAO:0000105 UMLS:C0014520 VHOG:0000077 XAO:0000028 ZFA:0000105 vertebrate epidermis uberon UBERON:0001003 skin epidermis UBERON:0001003 Functional system which consists of structures involved in respiration. The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO] There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG] AAO:0000541 BTO:0000203 CALOHA:TS-1319 EFO:0000804 EHDAA2:0001604 EHDAA:2203 EMAPA:16727 EV:0100036 FMA:7158 GAID:78 MA:0000327 MAT:0000030 MESH:D012137 MIAA:0000030 OpenCyc:Mx4rvVjzFJwpEbGdrcN5Y29ycA TAO:0000272 UMLS:C0035237 VHOG:0000202 XAO:0000117 ZFA:0000272 apparatus respiratorius respiratory system uberon Atmungssystem apparatus respiratorius systema respiratorium UBERON:0001004 respiratory system UBERON:0001004 An airway through which respiratory air passes in organisms. This class generically groups trachea and analagous structures throughout metazoa. Consider renaming, as the term could be taken to mean lumen of tracheal system (e.g. in SNOMED). As a grouping class this is quite vague, as it is not clear where the airway begins and ends airway airways FMA:265130 uberon UBERON:0001005 respiratory airway UBERON:0001005 Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO] digestive many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class AAO:0000129 BILA:0000082 BTO:0000058 CALOHA:TS-1293 EFO:0000793 EV:0100056 FBbt:00005055 FMA:7152 GAID:278 MA:0002431 MAT:0000018 MESH:D004064 MIAA:0000018 TADS:0000170 TAO:0000339 WBbt:0005748 XAO:0000125 ZFA:0000339 galen:DigestiveSystem ncithesaurus:Digestive_System uberon alimentary system alimentary tract gastrointestinal system gut UBERON:0001007 digestive system UBERON:0001007 organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. the cardiovascular system and the lymphatic system are parts of the circulatory system Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO] We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG] AAO:0000959 CALOHA:TS-2103 FBbt:00005057 OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA VHOG:0001248 uberon systema cardiovasculare UBERON:0001009 circulatory system UBERON:0001009 Portion of connective tissue composed of adipocytes enmeshed in areolar tissue Connective tissue in which fat is stored.[TAO] Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO] relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG] adipose In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen. in FMA this is dense irregular connective tissue AAO:0000001 AEO:000020 BTO:0001487 CALOHA:TS-0013 EFO:0000790 EHDAA2:0003120 EMAPA:35112 EV:0100381 FMA:20110 GAID:920 MA:0000009 MAT:0000015 MESH:D000273 MIAA:0000015 OpenCyc:Mx4rvVjc_ZwpEbGdrcN5Y29ycA TAO:0002134 UMLS:C0001527 VHOG:0001284 XAO:0003049 ZFA:0005345 galen:FattyTissue fat fat tissue fatty tissue uberon adipose bodyfat fatty depot UBERON:0001013 adipose tissue UBERON:0001013 A subdivision of the muscular system corresponding to a subdisivision of an organism. In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here. AAO:0011066 BTO:0000887 EFO:0001949 EMAPA:32715 EMAPA:35577 FMA:32558 MA:0000165 OpenCyc:Mx4rvVjmr5wpEbGdrcN5Y29ycA TAO:0000548 UMLS:C0026845 VSAO:0005038 WBbt:0005737 ZFA:0000548 muscle group muscles set musculature musculi set of muscles set of skeletal muscles uberon muscle system muscles musculature system UBERON:0001015 musculature UBERON:0001015 The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO] Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO] Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG] nervous neural AAO:0000324 BILA:0000079 BTO:0001484 CALOHA:TS-1313 EFO:0000802 EHDAA2:0001246 EHDAA:826 EMAPA:16469 EV:0100162 FBbt:00005093 FMA:7157 GAID:466 MA:0000016 MAT:0000026 MESH:D009420 MIAA:0000026 OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA TAO:0000396 UMLS:C0027763 VHOG:0000402 WBbt:0005735 XAO:0000177 ZFA:0000396 neurological system nerve net uberon systema nervosum UBERON:0001016 nervous system UBERON:0001016 The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. Part of the nervous system which includes the brain and spinal cord.[AAO] The brain and spinal cord. Kimmel et al, 1995.[TAO] The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] AAO:0000090 BAMS:CNS BILA:0000080 BTO:0000227 CALOHA:TS-0150 EFO:0000908 EHDAA2:0000225 EHDAA:828 EMAPA:16470 EMAPA:16754 EV:0100163 FBbt:00005094 FMA:55675 GAID:570 MA:0000167 MAT:0000457 MESH:D002490 OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA TAO:0000012 UMLS:C0927232 VHOG:0000293 XAO:0000215 ZFA:0000012 CNS systema nervosum centrale cerebrospinal axis uberon neuraxis UBERON:0001017 central nervous system UBERON:0001017 An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. A portion of tissue which is a fasiculated group of axons.[TAO] nervous AAO:0011070 AEO:0000137 BAMS:n BSA:0000098 BTO:0000925 BTO:0001027 CALOHA:TS-0772 EHDAA2:0003137 EHDAA:2851 EHDAA:3776 EHDAA:4657 EMAPA:32808 EMAPA:32815 EV:0100371 FBbt:00005105 FMA:65132 FMA:65239 GAID:747 GAID:758 MA:0000217 MA:0000228 MESH:D010525 OpenCyc:Mx4rwP3lkpwpEbGdrcN5Y29ycA TAO:0007009 UMLS:C0027740 UMLS:C0031119 VHOG:0000901 XAO:0000204 XAO:0003047 ZFA:0007009 galen:Nerve nerves peripheral nerve uberon neural subtree UBERON:0001021 nerve UBERON:0001021 Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG] note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs AAO:0000555 BAMS:SEN BILA:0000099 EFO:0000805 EHDAA2:0003094 EMAPA:16192 FBbt:00005827 FMA:75259 MA:0002442 MAT:0000031 MIAA:0000031 TAO:0000282 VHOG:0001674 XAO:0003194 ZFA:0000282 organa sensuum sense organ subsystem sense organs sense organs set sensory subsystem sensory systems uberon organa sensuum sensory organ system set of sense organs UBERON:0001032 sensory system UBERON:0001032 The sensory system for the sense of taste. The sensory system for the sense of taste[NIFSTD:nlx_anat_090803]. The sensory system used for the sense of taste.[AAO] gustatory in ZFA and MA this is a subtype of sensory system. we should change sensory system to disambiguate parts and wholes AAO:0010577 BILA:0000143 EFO:0000830 FMA:7194 MA:0002446 MAT:0000275 MIAA:0000275 TAO:0001101 XAO:0003197 ZFA:0001101 gustatory organ system taste system uberon UBERON:0001033 gustatory system UBERON:0001033 Anterior subdivision of a digestive tract. Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. In vertebrates the term may refer to a developmental structure The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder. The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] AAO:0011042 BILA:0000085 BTO:0000507 EHDAA2:0000557 EHDAA:520 EMAPA:16548 FBbt:00005379 FMA:45616 MA:0001526 TGMA:0001014 UMLS:C0231051 VHOG:0000285 XAO:0000232 uberon praeenteron proenteron UBERON:0001041 foregut UBERON:0001041 Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. AEO:0000171 BTO:0001886 EFO:0001652 EHDAA2:0003171 FBbt:00005495 FMA:86589 MAT:0000482 UMLS:C0678727 XAO:0003043 uberon bud future organ placode primordia rudiment UBERON:0001048 primordium UBERON:0001048 In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO] The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium AAO:0010617 BTO:0001057 CALOHA:TS-2371 DHBA:10154 EHDAA2:0001254 EHDAA:2869 EHDAA:908 EMAPA:16164 EMAPA:16530 EMAPA:16757 FMA:293882 MAT:0000069 MIAA:0000069 TAO:0001135 UMLS:C0231024 VHOG:0000307 XAO:0003204 ZFA:0001135 uberon neural primordium presumptive central nervous system tubus neuralis UBERON:0001049 neural tube UBERON:0001049 Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. AAO:0010841 AEO:0000000 BILA:0000000 CARO:0000000 EHDAA2:0002229 FBbt:10000000 FBbt_root:00000000 FMA:62955 HAO:0000000 MA:0000001 TAO:0100000 TGMA:0001822 UMLS:C1515976 XAO:0000000 ZFA:0100000 uberon UBERON:0001062 anatomical entity UBERON:0001062 Transudate contained in the synovial cavity of joints, and in the cavity of tendon sheaths and bursae. Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO] BTO:0001339 CALOHA:TS-0996 ENVO:02000039 FMA:12277 GAID:265 MA:0002544 MESH:D013582 TAO:0005154 UMLS:C0039097 ZFA:0005154 galen:SynovialFluid joint fluid uberon UBERON:0001090 synovial fluid UBERON:0001090 Muscle tissue that consists primarily of skeletal muscle fibers. Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]. Striated muscle tissue under control of the somatic nervous system. It is one of three major muscle types, the others being cardiac and smooth muscle. As its name suggests, most skeletal muscle is attached to bones by bundles of collagen fibers known as tendons. Skeletal muscle is made up of individual components known as muscle fibers. These fibers are formed from the fusion of developmental myoblasts. The myofibers are long, cylindrical, multinucleated cells composed of actin and myosin myofibrils repeated as a sarcomere, the basic functional unit of the cell and responsible for skeletal muscle's striated appearance and forming the basic machinery necessary for muscle contraction. The term muscle refers to multiple bundles of muscle fibers held together by connective tissue[WP]. TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle. Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO] Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA] This result implies the following views in terms of evolutionary differentiation: (1) Arthropod striated muscle and vertebrate skeletal and cardiac muscles share a common ancestor. In other words, they did not evolve independently (...) (5) The divergence of vertebrate skeletal and cardiac muscles/vertebrate smooth muscle and nonmuscle is at least before that of vertebrates/arthropods. In other words, emergence of skeletal and cardiac musle type tissues preceded the vertebrate/arthropod divergence (ca. 700 MYA).[well established][VHOG] UBERON:FMA_14069-MA_0002439 skeletal muscle AAO:0011099 BTO:0001103 EFO:0000888 EHDAA2:0001842 EHDAA:2923 EHDAA:5035 EHDAA:5043 EHDAA:5978 EHDAA:5984 EHDAA:8277 EHDAA:8291 EHDAA:8326 EHDAA:9146 EMAPA:32716 EV:0100377 FMA:14069 GAID:141 MA:0002439 MAT:0000302 MESH:A.02.633.567 MIAA:0000302 OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA SCTID:426215008 UMLS:C0242692 VHOG:0000319 XAO:0000174 ZFA:0005277 ncithesaurus:Skeletal_Muscle_Tissue skeletal muscle uberon skeletal muscle organ skeletal muscle system somatic muscle UBERON:0001134 TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Consider FBbt:00005073 - somatic muscle. skeletal muscle tissue UBERON:0001134 Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. http://en.wikipedia.org/wiki/ The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). AEO:0000111 BTO:0002422 CALOHA:TS-1183 EHDAA2_RETIRED:0003111 EHDAA:2331 EHDAA:2349 EHDAA:295 EHDAA:6073 EHDAA:640 EHDAA:646 EMAPA:32856 FMA:14074 MA:0000565 UMLS:C0086610 uberon UBERON:0001136 mesothelium UBERON:0001136 A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. dorsal In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body BTO:0001713 CALOHA:TS-2223 EFO:0001405 FMA:14181 GAID:30 MESH:A01.176 OpenCyc:Mx4rvVkEU5wpEbGdrcN5Y29ycA UMLS:C0004600 galen:Back back back of body proper dorsal part of organism uberon UBERON:0001137 dorsum UBERON:0001137 Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO] Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO] System that provides physical support to the organism.[AAO] By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG] skeletal GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates AAO:0000566 BTO:0001486 CALOHA:TS-1320 EFO:0000806 EHDAA2:0003168 EMAPA:35773 FMA:23881 MA:0000018 OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA TAO:0000434 UMLS:C0037253 VHOG:0001254 VSAO:0000027 XAO:0003060 ZFA:0000434 skeleton system set of all bones and joints uberon Skelettsystem UBERON:0001434 skeletal system https://github.com/obophenotype/uberon/wiki/The-skeletal-system UBERON:0001434 FMA:24218 XAO:0000040 head subdivision uberon head region region of head UBERON:0001444 subdivision of head UBERON:0001444 A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face. The area that extends from the median ocellus to the oral foramen[HAO]. facial The face develops from outward growth of tissue located rostral to the cranium & pharynx. The lower jaw and most of the upper jaw are formed by growth of the first pharyngeal (branchial) arch. The upper incisor region and the nose and forehead (frontal region) are formed from tissue located rostral to the neural tube (frontonasal prominence) BTO:0003369 CALOHA:TS-2216 EMAPA:32763 FMA:24728 GAID:64 HAO:0000316 MA:0002473 MESH:D005145 OpenCyc:Mx4rvVi5GZwpEbGdrcN5Y29ycA UMLS:C0015450 galen:Face uberon facia/facies visage UBERON:0001456 face UBERON:0001456 Skeletal element that is composed of bone tissue. Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO] Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO] Skeletal element that is composed of bone tissue.[VSAO] relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG] AAO:0000047 AEO:0000082 BTO:0000140 CALOHA:TS-0088 EFO:0000298 EHDAA2:0003082 EMAPA:32782 ENVO:00002039 EV:0100140 FMA:30317 FMA:5018 GAID:92 MA:0001459 MAT:0000299 MIAA:0000299 OpenCyc:Mx4rvViDlpwpEbGdrcN5Y29ycA OpenCyc:Mx4rvVkCG5wpEbGdrcN5Y29ycA TAO:0001514 UMLS:C0262950 VHOG:0001190 VSAO:0000057 XAO:0000169 ZFA:0001514 galen:Bone bone element bone organ uberon bone bones UBERON:0001474 bone element UBERON:0001474 An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. check ncita FMA:34836 GAID:263 MA:0001519 MESH:D017746 UMLS:C0206207 galen:JointCapsule capsula articularis fibrous capsule of joint joint capsule joint fibrous capsule uberon capsulae articulares UBERON:0001484 articular capsule UBERON:0001484 A tube extending from the mouth to the anus. The alimentary or digestive tract, and associated organs.[TAO] The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] FMA also has a term 'gastrointestinal tract', but this includes the liver. we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509 we following Kardong in naming the entire tube from mouth to anus the alimentary canal. Kardong calls the portion of this tract that excludes buccal cavity and pharynx the 'alimentary canal', consider adding an extra class for this gut AAO:0010023 BILA:0000083 BTO:0000511 BTO:0000545 EHDAA2:0000726 EHDAA:518 EMAPA:16247 FBbt:00003125 FMA:45615 MA:0000917 OpenCyc:Mx4rvVi0GpwpEbGdrcN5Y29ycA TAO:0000112 TGMA:0001819 UMLS:C0017189 VHOG:0000309 WBbt:0005743 ZFA:0000112 galen:AlimentaryTract digestive tube enteric tract alimentary canal alimentary tract uberon digestive canal gut tube UBERON:0001555 digestive tract UBERON:0001555 The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea. Some specify that the glottis (vocal cords) is the defining line between the upper and lower respiratory tracts;[2] yet even others make the line at the cricoid cartilage. The FMA includes nose, nasopharynx, oropharynx and larynx[WP] EHDAA2:0002136 EMAPA:17669 FMA:45661 MA:0000442 OpenCyc:Mx4rtT2HwgJMEdyAAADggVbxzQ VHOG:0000406 uberon UBERON:0001557 upper respiratory tract UBERON:0001557 The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified] EHDAA2:0001036 EMAPA:16738 FMA:45662 MA:0000435 OpenCyc:Mx4rQRqjUgAKEdyHxgDggVfs8g VHOG:0000382 uberon UBERON:0001558 lower respiratory tract UBERON:0001558 Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. Portion of tissue composed of contractile fibers.[TAO] It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG] muscular muscle AAO:0011066 EMAPA:32715 EV:0100146 FMA:5022 GAID:131 MA:0000015 OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA TAO:0005145 VHOG:0001245 XAO:0000172 ZFA:0005145 galen:Muscle uberon UBERON:0001630 muscle organ UBERON:0001630 Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. The organ of hearing and of equilibrium. [TFD][VHOG] Both vertebrate and invertebrate auditory organs are thought to have evolved from primitive mechanosensors, but the nature of the ancestral structure and the evolutionary trajectories followed in distinct animal lineages remain unknown. In particular, we do not know how many types of mechanosensor existed in the protostome-deuterostome ancestor from which insects and vertebrates evolved or whether the PDA had an auditory organ.[well established][VHOG] auricular AAO:0011014 BTO:0000368 CALOHA:TS-1165 EFO:0000826 EHDAA2:0000423 EHDAA:502 EMAPA:16193 EV:0100353 FMA:52780 GAID:62 MA:0000236 MAT:0000138 MESH:D004423 MIAA:0000138 OpenCyc:Mx4rvViXS5wpEbGdrcN5Y29ycA OpenCyc:Mx4rvVjL05wpEbGdrcN5Y29ycA UMLS:C0013443 UMLS:C0521421 VHOG:0000330 XAO:0000189 galen:Ear uberon auditory apparatus auris UBERON:0001690 ear UBERON:0001690 A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP]. Use this class for both the nails of primates and the homologous claws of mammals such as mouse. A primate's nail consists of the unguis alone; the subunguis has disappeared BTO:0001719 CALOHA:TS-2034 EFO:0000956 EMAPA:35580 EV:0100159 FMA:54326 GAID:1320 MA:0002703 MAT:0000158 MESH:D009262 MIAA:0000158 OpenCyc:Mx4rvVjJv5wpEbGdrcN5Y29ycA UMLS:C0027342 VHOG:0001361 XAO:0003103 galen:Nail nail/claw claw uberon talon UBERON:0001705 The nails of humans and the claws are moth are highly similar. Both species have a proximal nail fold, cuticle, nail matrix, nail bed, nail plate, and hyponychium. Distinguishing features are the shape of the nail and the presence of an extended hyponychium in the mouse [PMC3579226] nail UBERON:0001705 the groups of nerve cell bodies associated with the twelve cranial nerves Ganglion which is located in the head.[TAO] UBERON:0003213 UBERON:0026601 BTO:0000106 EFO:0000902 EMAPA:16659 FMA:54502 MA:0000213 MA:0000214 MAT:0000200 MIAA:0000200 TAO:0000013 VHOG:0000076 XAO:0000027 ZFA:0000013 cranial ganglion cranial ganglion part of peripheral nervous system cranial ganglion/nerve cranial nerve ganglion cranial neural ganglion cranial neural tree organ ganglion ganglion of cranial nerve ganglion of cranial neural tree organ uberon cranial ganglia head ganglion presumptive cranial ganglia UBERON:0001714 cranial ganglion UBERON:0001714 the any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified] Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG] AAO:0011101 BAMS:spin BTO:0000870 EHDAA2:0001898 EMAPA:16989 FMA:5858 GAID:841 MA:0000233 MESH:D013127 OpenCyc:Mx4rwK_iFJwpEbGdrcN5Y29ycA UMLS:C0037941 VHOG:0000824 XAO:0003101 backbone nerve nerve of backbone nerve of spinal column nerve of spine nerve of vertebral column spinal column nerve spinal nerve tree spine nerve vertebral column nerve uberon nervi spinales spinal nerves UBERON:0001780 spinal nerve UBERON:0001780 Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. classified as neural tree organ, not nerve in FMA. CN II poses a challenge here as it is not strictly a nerve, yet is expected to be classified under CN. Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG] See https://github.com/obophenotype/mouse-anatomy-ontology/issues/6 AAO:0000108 BAMS:cran BTO:0001104 EHDAA2:0000323 EMAPA:17264 FMA:5865 GAID:802 HBA:9299 MA:0000215 MBA:967 MESH:D003391 OpenCyc:Mx4rvWvJVpwpEbGdrcN5Y29ycA TAO:0000641 UMLS:C0010268 UMLS:C1269897 VHOG:0000279 XAO:0000429 XAO:0003089 ZFA:0000641 cranial neural tree organ uberon cranial nerves nervus cranialis UBERON:0001785 cranial nerve UBERON:0001785 The most anterior region the brain including both the telencephalon and diencephalon. Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO] The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO] relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO] In craniate embryos, neural expression of Distal-less-related genes is exclusively in the forebrain (...). Because the major neural expression domain of amphioxus AmphiDll is in the anterior three-fourths of the cerebral vesicle, we suggest that this region of the neural tube is homologous to parts of the craniate forebrain. This conclusion is strongly supported by three-dimensional, computer-assisted reconstruction of the neural tube of amphioxus based on serial transmission electron microscopy. At the neuroanatomical level, a number of detailed homologies are indicated between the anterior three-fourths of the amphioxus cerebral vesicle and the diencephalic region of the craniate forebrain. If one assumes that the amphioxus condition fairly represents the nervous system of the proximate ancestor of the craniates, one can suggest that they evolved from a creature that had the beginnings of a forebrain.[well established][VHOG] prosencephalic FB AAO:0010147 BAMS:FB BAMS:Forebrain BTO:0000478 CALOHA:TS-0380 DHBA:10156 DMBA:15566 EFO:0000909 EHDAA2:0000556 EHDAA:3470 EMAPA:16895 FMA:61992 MA:0000170 MAT:0000105 MESH:D016548 MIAA:0000105 TAO:0000109 UMLS:C0085140 VHOG:0000383 XAO:0000011 ZFA:0000109 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=27 uberon prosencephalon UBERON:0001890 forebrain UBERON:0001890 The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. developmental relationships need revised Middle part of the brain composed of the optic tectum and penducular region.[AAO] The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO] Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] mesencephalic part of brainstem in ABA - we reject this in favor of ISBN10:0471888893 which has an implicit overlaps relationships MB AAO:0010149 BAMS:MES BM:MB BTO:0000138 CALOHA:TS-0630 DHBA:10648 DMBA:16649 EFO:0000919 EHDAA2:0001162 EHDAA:3694 EMAPA:16974 EV:0100242 FMA:61993 HBA:9001 MA:0000207 MAT:0000106 MBA:313 MESH:D008636 MIAA:0000106 OpenCyc:Mx4rvsBUqpwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0001104 TAO:0000128 UMLS:C0025462 VHOG:0000069 XAO:0000014 ZFA:0000128 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=462 uberon mesencephalon UBERON:0001891 midbrain UBERON:0001891 Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres. Organ component of neuraxis that has as its parts the cerebral cortex, cerebral white matter, basal ganglia, septum and fornix, as well as subcortical gray and white matter structures[FMA:62000]. Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres.[AAO] The anterior and dorsal forebrain neuromere, includes the olfactory bulb. Kimmel et al, 1995.[TAO] relationship loss: develops_from presumptive telencephalon (TAO:0000571)[TAO] From an evolutionary standpoint, the telencephalon is the most recent brain structure: the amphioxus does not have this structure as a morphological entity. Overt telencephalon is present in the hagfish and lamprey to receive numerous input fibers from various parts of the CNS, similar to gnathostomes.[well established][VHOG] cerebral telenencephalic In mammals the cortex covers almost the whole of the cerebral hemispheres. In ray-finned fishes the inner surfaces of the lateral and ventral regions of the cerebrum bulge up into the ventricles. In the amniotes, the cerebrum becomes increasingly large and complex. In reptiles, the paleopallium is much larger than in amphibians, and its growth has pushed the basal nuclei into the central regions of the cerebrum. In the most primitive living vertebrates, the hagfishes and lampreys, the cerebrum is a relatively simple structure receiving nerve impulses from the olfactory bulb. The cerebrum of birds has evolved along different lines to that of mammals, although they are similarly enlarged, by comparison with reptiles. However, this enlargement is largely due to the basal ganglia, with the other areas remaining relatively primitive in structure. dolphins are the only species (other than humans) to have cerebra accounting for as much as 2 percent of their body weight. supratentorial region AAO:0010479 BAMS:CB BAMS:CH BAMS:IV BAMS:Tel BM:Tel BTO:0000239 CALOHA:TS-1018 DHBA:10158 EFO:0000912 EHDAA2:0001982 EMAPA:16652 EMAPA:16910 EV:0100165 FMA:62000 GAID:621 HBA:4007 MA:0000183 MAT:0000421 MBA:567 MESH:D013687 MIAA:0000421 PBA:128011350 TAO:0000079 UMLS:C0039452 VHOG:0000283 XAO:0000012 ZFA:0000079 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31 cerebrum endbrain uberon UBERON:0001893 telencephalon UBERON:0001893 Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]. Anterior part of the hindbrain ventral to the cerebellum[NIFSTD:birnlex_965]. The anterior of two brain vesicles formed by specialization of the rhombencephalon in the developing embryo. It gives rise to cerebellum and pons. [TFD][VHOG] The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] epencephalon BAMS:Met BTO:0000673 CALOHA:TS-2029 DHBA:10655 EHDAA2:0001149 EHDAA:5498 EMAPA:17071 FMA:62003 GAID:594 HBA:4833 MA:0000197 MESH:D020540 UMLS:C0376353 UMLS:C1516904 VHOG:0000741 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=543 epencephalon-2 uberon UBERON:0001895 the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]. metencephalon UBERON:0001895 Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO] The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG] bulb medulla AAO:0010486 BAMS:MY BAMS:Md BM:Me BTO:0000041 CALOHA:TS-0607 DMBA:17352 EFO:0000924 EHDAA2:0001088 EHDAA:7588 EMAPA:17550 EV:0100275 FMA:62004 GAID:590 MA:0000206 MAT:0000111 MAT:0000367 MBA:354 MESH:D008526 MIAA:0000111 OpenCyc:Mx4rvVjxSJwpEbGdrcN5Y29ycA OpenCyc:Mx4rwCqnXJwpEbGdrcN5Y29ycA TAO:0000545 UMLS:C0025148 UMLS:C1269575 VHOG:0000181 XAO:0003100 ZFA:0000545 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=698 bulbus uberon medulla oblonzata metepencephalon UBERON:0001896 medulla oblongata UBERON:0001896 Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN10:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG] MTg tegmentum BAMS:MTg BTO:0003388 DHBA:12195 EFO:0000921 EHDAA2:0004475 EMAPA:18215 FMA:62393 HBA:9002 MA:0000212 MAT:0000452 TAO:0000160 UMLS:C0039441 VHOG:0001367 XAO:0004271 ZFA:0000160 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=491 tegmentum mesencephali tegmentum of midbrain uberon mesencephalic tegmentum tegmentum mesencephalicum UBERON:0001943 'tegmentum' is used generically for the ventral part of the brainstem (ISBN10:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum midbrain tegmentum UBERON:0001943 The liquid component of blood, in which erythrocytes are suspended. plasma portion of plasma BTO:0000131 CALOHA:TS-0800 EFO:0001905 EMAPA:35690 FMA:62970 GAID:1178 MA:0002501 MAT:0000052 MESH:D010949 MIAA:0000052 OpenCyc:Mx4rEg4ZYrIbEduAAAAOpmP6tw UMLS:C0032105 blood plasm portion of blood plasma uberon UBERON:0001969 blood plasma UBERON:0001969 A vessel through which blood circulates in the body. consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG] Any of the vessels through which blood circulates in the body.[AAO] The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] annelids have blood vessels, but this class is not applicable to annelids. FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX vascular element AAO:0011004 AEO:0000207 BTO:0001102 CALOHA:TS-0080 EFO:0000817 EHDAA2:0003252 EHDAA:240 EMAPA:32743 EMAPA:35993 FMA:50722 FMA:63183 GAID:169 MA:0000060 MAT:0000393 MESH:D001808 OpenCyc:Mx4rvVjxlpwpEbGdrcN5Y29ycA TAO:0002137 UMLS:C0005847 VHOG:0001250 XAO:0001011 ZFA:0005314 region of vascular tree organ vascular tree organ region uberon vas sanguineum UBERON:0001981 blood vessel UBERON:0001981 A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO] AEO:0001012 EHDAA2:0003136 EHDAA2_RETIRED:0004658 FMA:67242 HBA:4006 MA:0001112 OpenCyc:Mx4rwDdKMpwpEbGdrcN5Y29ycA TAO:0002197 UMLS:C0018220 VHOG:0001768 ZFA:0001681 gray matter gray matter of neuraxis grey matter grey matter of neuraxis grey substance neuronal grey matter substantia grisea uberon gray mater grisea UBERON:0002020 gray matter UBERON:0002020 The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO] The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO] relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO] Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] rhombencephalic in MA, brainstem and hindbrain and part-of siblings under brain, consistent with FMA and NIF. See also notes for cerebellum. We weaken the relation in ABA to overlaps AAO:0010150 BAMS:HB BTO:0000672 CALOHA:TS-0457 DHBA:10653 DMBA:16808 EFO:0000923 EHDAA2:0000746 EHDAA:3514 EHDAA:6487 EMAPA:16916 FMA:67687 MA:0000195 MAT:0000107 MBA:1065 MESH:D012249 MIAA:0000107 TAO:0000029 UMLS:C0035507 UMLS:C1522180 VHOG:0000070 XAO:0000015 ZFA:0000029 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=540 uberon rhombencephalon UBERON:0002028 hindbrain UBERON:0002028 Muscle tissue that contains fibers that are divided by transverse bands into striations. Voluntary muscle tissue arranged in bundles of fibers.[AAO] AAO:0010762 AEO:0000140 CALOHA:TS-2047 EHDAA2:0003140 EMAPA:36390 FMA:67905 MA:0002438 OpenCyc:Mx4rwAoze5wpEbGdrcN5Y29ycA UMLS:C1331262 WBbt:0005779 galen:StriatedMuscle striated muscle uberon UBERON:0002036 striated muscle tissue UBERON:0002036 Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]. Dorsal part of the hindbrain that coordinates muscle movement, posture, and balance.[AAO] Specialized brain region derived from the dorsal metencephalon (anterior hindbrain, and perhaps including posterior midbrain) and becoming distinctive late in the segmentation period. Kimmel et al, 1995.[TAO] However, although the lamprey possesses a region comparable to the cerebellum and display expression of LjFgf8/17 at the MHB (midbrain hindbrain boundary), it does not have Purkinje cells and cerebellar nuclei, as well as components of the rhombic lip-derived cerebellar and pre-cerebellar systems. It is noteworthy that the latter structures require specific expression of Pax6 in the rhombic lip of the gnathostome hindbrain. Interestingly, the lamprey rhombic lip does not express Pax6. Thus, it is tempting to speculate that in vertebrate evolution the rostral hindbrain is incapable of differentiating into the cerebellum before the co-option of Pax6 in that region. In other words, cerebellum has been brought about as an evolutionary innovation in gnathostomes, based on exaptation of MHB, rhombic lip, and some regulatory gene expression already present in the vertebrate common ancestor.[well established][VHOG] cerebellar The absence of a cerebellum in hagfishes and lampreys appears to be the only exception [to the rule that vertebrates possess the same number of brain divisions]. Both hagfishes and lampreys do possess a thin band of cells located medial to the lateral line centers of the medulla (Ronan and Northcutt, 1998), which has been interpreted as a primitive cerebellum (Larsell, 1967), but more recent experimental studies (Kishida et al., 1987; Weigle and Northcutt, 1998) fail to support Larsell's claim[http://icb.oxfordjournals.org/content/42/4/743.full] almost all AOs agree that the cerebellum is part of the hindbrain (sometimes specifically part of the metencephalon, which, when present, is part of the hindbrain). However, ABA has cerebellum and brain stem as partof siblings, with the hindbrain part of the brainstem infratentorial region AAO:0010485 BAMS:CB BAMS:Cb BM:CB BTO:0000232 CALOHA:TS-0125 DHBA:10656 EFO:0000327 EHDAA2:0000232 EMAPA:17787 EV:0100293 FMA:67944 GAID:595 HBA:4696 MA:0000198 MAT:0000110 MBA:512 MESH:D002531 MIAA:0000110 OpenCyc:Mx4rvl1eipwpEbGdrcN5Y29ycA TAO:0000100 UMLS:C0007765 UMLS:C1268981 VHOG:0000024 XAO:0003098 ZFA:0000100 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=643 epencephalon-1 uberon corpus cerebelli parencephalon UBERON:0002037 cerebellum UBERON:0002037 Respiration organ that develops as an oupocketing of the esophagus. Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO] Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG] pulmonary respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi AAO:0000275 AAO:0010567 BTO:0000763 CALOHA:TS-0568 EFO:0000934 EHDAA2:0001042 EHDAA:1554 EHDAA:2205 EMAPA:16728 EV:0100042 FMA:7195 GAID:345 MA:0000415 MAT:0000135 MESH:D008168 MIAA:0000135 OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA UMLS:C0024109 VHOG:0000310 XAO:0000119 galen:Lung pulmo uberon UBERON:0002048 Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] lung UBERON:0002048 An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. see also: vascular system. Consider merging? vascular BTO:0003718 FMA:69050 TAO:0005249 ZFA:0005249 vascular network uberon UBERON:0002049 vasculature UBERON:0002049 Anatomical structure that is part of an embryo. Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO] Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO] Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO] in FMA embryo is_a embryonic structure AAO:0000138 BILA:0000034 BTO:0000174 CALOHA:TS-2110 EFO:0000461 FBbt:00004208 FMA:69067 GAID:407 MESH:D004628 RETIRED_EHDAA2:0003169 TAO:0001105 UMLS:C0013948 VSAO:0000178 XAO:0003042 ZFA:0001105 developing embryonic structure embryonic anatomical structure uberon developing structure embryonale Struktur embryonic structures UBERON:0002050 embryonic structure UBERON:0002050 The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. Consider adding a layer-of-skin grouping class for all skin layers A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO] When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG] dermal AAO:0000128 BTO:0000294 CALOHA:TS-2076 EFO:0000953 EMAPA:17527 EV:0100154 FMA:70323 GAID:1321 MA:0000152 MAT:0000153 MESH:D020405 MIAA:0000153 TAO:0001119 UMLS:C0011646 VHOG:0000108 XAO:0000217 ZFA:0001119 vertebrate dermis uberon corium cutis UBERON:0002067 dermis UBERON:0002067 Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA]. A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO] A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]. hypodermal subcutaneous subcutaneus BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument. UBERON:FMA_70544-MIAA_0000418-ZFA_0000117-ZFA_0001136 BTO:0001314 BTO:0004525 CALOHA:TS-2366 FMA:70544 FMA:9630 GAID:929 MESH:A.10.165.887 TAO:0001136 UMLS:C0278403 ZFA:0001136 http://upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Skin.svg/200px-Skin.svg.png ncithesaurus:Superficial_Fascia hypoderm superficial fascia tela subcutanea vertebrate hypodermis uberon sub-tegumental tissue subcutaneous tissue subcutis subtegumental tissue superficial fascia tela subcutanea UBERON:0002072 Note that this class combines superficial fascia and hypodermis in FMA. Note also BTO has 'subcutis' hypodermis UBERON:0002072 The post-cranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO] The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO] The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO] The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG] axial skeleton AAO:0000034 EFO:0000942 EHDAA2:0000161 EHDAA:5049 EMAPA:17214 FMA:71221 MA:0002986 MAT:0000148 MIAA:0000148 TAO:0000317 VHOG:0000317 VSAO:0000093 XAO:0003073 ZFA:0000317 post-cranial axial skeleton uberon UBERON:0002090 previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. postcranial axial skeleton http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton UBERON:0002090 Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. Skeletal subdivision consisting of all the skeletal elements in the pectoral and pelvic appendage complexes.[VSAO] Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO] The pectoral and pelvic girdles, which articulate with the axial skeleton, together with their associated limbs, the forelimbs and hind limbs, form the appendicular skeleton.[AAO] ontologies differ in whether they treat the term appendicular skeleton as being the entire set of bones in the limbs, or whether the fore and hind limbs/fins are treated as seperate appendicular skeletons. Here we follow FMA, and treat the appendicular skeleton as the sum total of skeletal elements in the organism (this is evidenced by the fact that in FMA, skeleton of left/right upper/lower limb is part_of a appendicular skeleton, and subtypes of 'subdivision of appendicular skeleton'). We have separate classes such as 'skeleton of limb', and 'skeleton of hindlimb' for the 4 parts of the appendicular skeleton. In future the ZFA/TAO classes may be moved. AAO:0000747 EFO:0000951 EMAPA:32729 FMA:71222 MA:0000290 MAT:0000278 MIAA:0000278 UMLS:C0222646 VHOG:0001666 VSAO:0000076 XAO:0003166 appendicular skeleton entire appendicular skeleton paired fin skeleton uberon skeleton appendiculare UBERON:0002091 appendicular skeleton https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton UBERON:0002091 Nonparenchymatous organ that consists of the dermis and epidermis. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body. Examples: There is only one skin[FMA]. Surface structure that consists of the external membranous integument of the animal. The organ covering the body that consists of the dermis and epidermis. consider 'integumentary system' for invertebrates MA uses the term skin to refer to what is called here: zone of skin UBERON:FMA_7163-MA_0000151-MIAA_0000284-XAO_0000023 BTO:0001253 CALOHA:TS-0934 EFO:0000962 EHDAA2:0001844 EMAPA:17525 FMA:7163 MESH:A.17.815 MESH:D012867 MFMO:0000099 OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA SCTID:181469002 UMLS:C1123023 XAO:0000023 galen:Skin http://upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Skin.svg/200px-Skin.svg.png ncithesaurus:Skin entire skin skin organ uberon entire integument integument integumental organ pelt skin UBERON:0002097 Note that FMA uses 'skin' for the entire organ. XAO seems consistent. MA seems to use it analagously to zone of skin skin of body UBERON:0002097 Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO] Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO] AAO:0010339 BILA:0000116 BTO:0001493 CALOHA:TS-1071 EFO:0000966 EMAPA:31857 FMA:7181 MA:0000004 MAT:0000296 MIAA:0000296 OpenCyc:Mx4rvVkJjpwpEbGdrcN5Y29ycA TAO:0001115 UMLS:C0460005 XAO:0000054 XAO:0003025 ZFA:0001115 galen:Trunk thoracolumbar region torso trunk region uberon Rumpf UBERON:0002100 trunk UBERON:0002100 A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts. Organism subdivision that has as its parts the jointed appendages used for locomotion and manipulation.[AAO] Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG] AAO:0010336 AEO:0000172 CALOHA:TS-0552 EFO:0000876 EHDAA2:0003172 EHDAA:1697 EHDAA:8273 EMAPA:16405 FMA:24875 GAID:36 MA:0000007 MAT:0000090 MIAA:0000090 OpenCyc:Mx4rvn1uSZwpEbGdrcN5Y29ycA UMLS:C0015385 VHOG:0000336 VSAO:0000121 XAO:0003027 galen:Extremity free limb limb sensu vertebrata pentadactyl limb tetrapod limb flipper uberon extremities extremity UBERON:0002101 limb UBERON:0002101 Sensory system responsible for the perception of spatial orientation and auditory stimuli. The sensory system used for balance and hearing.[AAO] AAO:0000631 EMAPA:36002 FMA:78500 TAO:0001138 XAO:0003195 ZFA:0001138 auditory organ system vestibuloauditory system uberon auditory system auditory/vestibular system vestibuloauditory system UBERON:0002105 vestibulo-auditory system UBERON:0002105 Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA] Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern EHDAA2:0001730 EHDAA:4969 EMAPA:17661 FMA:7309 MA:0000426 OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvVjKy5wpEbGdrcN5Y29ycA UMLS:C0225706 VHOG:0000301 uberon UBERON:0002167 right lung UBERON:0002167 Lung which consists of the left upper lobe and left lower lobe.[FMA] Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata.[well established][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern EHDAA2:0000943 EHDAA:4947 EMAPA:17653 FMA:7310 MA:0000425 OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvVjKy5wpEbGdrcN5Y29ycA UMLS:C0225730 VHOG:0000618 uberon UBERON:0002168 left lung UBERON:0002168 Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. CALOHA:TS-2018 EHDAA2:0004615 EMAPA:18765 FMA:74562 MA:0000013 hematolymphoid system lymphomyeloid complex uberon haemolymphoid system UBERON:0002193 hemolymphoid system UBERON:0002193 The dermis, epidermis and hypodermis. in FMA intergument = skin+superficial fascia(hypodermis), skin=dermis+epidermis+hair_nail. Note that the definition provided here excludes the more general sense of the term 'integument' used in invertebrates; consider 'integumental system'. Note that the VSAO class appears to include adnexa by its definition. Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO] Surface structure that is the outer protective covering of the body.[VSAO] The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO] integumental integumentary AAO:0000239 BTO:0000634 FMA:74657 TAO:0000368 VSAO:0000029 ZFA:0000368 galen:Integument dermis plus epidermis plus hypodermis integumentum commune skin and subcutaneous tissue skin plus hypodermis the integument uberon Hautsystem@de dermal system dermoid system skin tegument vertebrate integument UBERON:0002199 integument UBERON:0002199 Anatomical system that consists of the muscular and skeletal systems. Anatomical system that provides locomotion and physical support to the organism.[AAO] There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG] musculoskeletal AAO:0010546 CALOHA:TS-1311 EMAPA:32714 EV:0100139 FMA:7482 GAID:98 MA:0002418 MESH:D009141 OpenCyc:Mx4rQRpVNgAKEdyHxgDggVfs8g UMLS:C0026860 VHOG:0001275 VSAO:0000031 XAO:0000168 musculo-skeletal system uberon UBERON:0002204 musculoskeletal system UBERON:0002204 Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA] Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO] AEO:0000183 CALOHA:TS-2138 EHDAA2:0003183 FMA:7501 MA:0000322 OpenCyc:Mx4rv2bBV5wpEbGdrcN5Y29ycA TAO:0005153 ZFA:0005153 galen:SynovialJoint articulatio synoviale diarthroses diarthrosis diarthrosis joint uberon diarthrodial joints UBERON:0002217 synovial joint UBERON:0002217 The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. In many species, the diaphragm separates thoracic and abdominal cavities EMAPA:36497 FMA:7565 GAID:93 MA:0000032 MESH:A01.911.800 OpenCyc:Mx4rmvyleLfEEduAAAACs6hRXg OpenCyc:Mx4rvhU_TpwpEbGdrcN5Y29ycA UMLS:C0230139 cavitas thoracis cavity of chest cavity of thorax chest cavity pectoral cavity space of thoracic compartment thoracic lumen uberon UBERON:0002224 thoracic cavity UBERON:0002224 Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO) TODO - add superclass to unify with VNC? Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] AAO:0010151 BAMS:SP BAMS:Spinal BM:SpC BTO:0001279 CALOHA:TS-0953 DHBA:12890 DMBA:17651 EFO:0000110 EHDAA2:0001255 EHDAA:2863 EMAPA:17577 EV:0100316 FMA:7647 GAID:695 MA:0000216 MAT:0000183 MESH:D013116 MIAA:0000183 OpenCyc:Mx4rvVjjk5wpEbGdrcN5Y29ycA TAO:0000075 UMLS:C0037925 VHOG:0000601 XAO:0000020 ZFA:0000075 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=22 uberon SpC cerebro-cerebellar fissure cerebrocerebellar fissure fissura cerebro-cerebellaris fissura cerebrocerebellaris medulla spinalis spinal cord structure spinal medulla UBERON:0002240 spinal cord UBERON:0002240 An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ. An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint fma general anatomical term. xao has no subtypes (but Johnstons organ develops from this). An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint AAO:0010180 BTO:0001772 FBbt:00005158 FMA:77659 VHOG:0000287 XAO:0000273 olfactory organ olfactory sense organ olfactory sensory organ main olfactory organ primary olfactory organ uberon olfactory neuroepithelium organ olfactus organum olfactorium UBERON:0002268 olfactory organ UBERON:0002268 Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO] Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,adopted][ZFA:0001707]. the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord[MP] BAMS:BS BTO:0000146 CALOHA:TS-0093 EFO:0001962 EMAPA:32678 EV:0100241 FMA:79876 MA:0000169 MBA:343 MESH:D001933 TAO:0002156 UMLS:C0006121 VHOG:0001457 ZFA:0001707 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=236 brain stem truncus encephali uberon accessory medullary lamina of pallidum lamella pallidi incompleta lamina medullaris accessoria lamina medullaris incompleta pallidi lamina pallidi incompleta truncus encephalicus UBERON:0002298 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN10:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). brainstem UBERON:0002298 The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. check the FMA placement here; ncit placement of body cavity here probably not correct Anatomical space, part of the trunk that contains the pericardial and pleuroperitoneal cavities[ZFA]. The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO]. In mammals it forms the peritoneal, pleural, and pericardial cavities UBERON:0000169 body cavity AEO:0000186 BTO:0001707 EHDAA2:0000267 FBbt:00005060 FMA:85006 RETIRED_EHDAA2:0003186 TAO:0001438 UMLS:C0333343 ZFA:0001438 galen:BodyCavity coelomic cavity coelomic cavity lumen main body cavity space of body compartment ventral body cavity uberon celom coelom coelome hemocoel UBERON:0002323 coelemic cavity lumen UBERON:0002323 A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO] Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO] Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO] relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG] notochordal In between vertebra the notochord becomes the nucleus pulposus, under it degenerates, and at anterior end in some species its tissue merges with some of the cranial bones.. Some organisms retain a post-embryonic notochord. AAO:0000327 BTO:0001768 CALOHA:TS-0690 EHDAA2:0001277 EHDAA:1241 EHDAA:6021 EMAPA:16191 EV:0100002 FMA:85521 GAID:1311 MAT:0000281 MESH:A16.254.610 TAO:0000135 UMLS:C0028439 VHOG:0000199 VSAO:0000032 XAO:0000055 ZFA:0000135 embryonic notocord notocord uberon notochorda UBERON:0002328 The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] notochord UBERON:0002328 Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk Post-cranial axial segments which form sclerotome and dermomyotome.[AAO] Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO] relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO] relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO] relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO] (...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG] somitic mesodermal cluster AAO:0010569 AEO:0001015 BTO:0001558 EHDAA2:0003436 EHDAA:366 EHDAA:699 EMAPA:31169 FMA:85522 GAID:1306 MAT:0000068 MESH:A16.254.425.660.750 MIAA:0000068 TAO:0000155 UMLS:C0376449 VHOG:0000191 XAO:0000058 ZFA:0000155 uberon epimere epimere mesoderm epithelial somite somites somitic mesoderm somitus UBERON:0002329 When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] somite UBERON:0002329 Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. CALOHA:TS-2057 EHDAA2:0002225 EMAPA:35329 FMA:85539 MA:0002411 UMLS:C1516995 WikipediaCategory:Exocrine_system exocrine glandular system uberon UBERON:0002330 exocrine system UBERON:0002330 A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO] Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO] A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831] We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG] AAO:0010578 BTO:0001764 CALOHA:TS-0676 EHDAA2:0004419 EMAPA:32737 FMA:86666 GAID:1310 MAT:0000066 MESH:A16.254.600 MIAA:0000066 TAO:0000045 UMLS:C0027789 VHOG:0000057 XAO:0000048 ZFA:0000045 NC uberon crista neuralis neural crest material UBERON:0002342 Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. neural crest UBERON:0002342 Embryonic ectoderm that gives rise to nervous tissue. (...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG] neurectodermal we prefer neurectoderm to neural ectoderm since placodal ectoderm is not classified here AAO:0011074 BILA:0000039 CALOHA:TS-1212 EHDAA2:0001248 EHDAA:1498 EHDAA:255 EMAPA:16073 EV:0100004 FBbt:00001061 FMA:87657 MAT:0000176 MIAA:0000176 TAO:0001120 UMLS:C1518271 VHOG:0000150 XAO:0000042 ZFA:0001120 neural ectoderm neuroectoderm uberon epithelium tubi neuralis; neuroectoderma neuaral ectoderm presumptive central nervous system ventral neurogenic region UBERON:0002346 neurectoderm UBERON:0002346 A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses AEO:0000097 BTO:0000765 CALOHA:TS-2012 EHDAA2:0003097 EMAPA:35327 FMA:9596 GAID:34 MA:0002564 MESH:D005088 UMLS:C0015282 ducted gland glandula exocrina uberon UBERON:0002365 exocrine gland UBERON:0002365 Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO] Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO] Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO] MA also has set of connective tissues AAO:0000098 BTO:0000421 CALOHA:TS-2009 EFO:0000952 EMAPA:35251 FMA:9640 GAID:100 MA:0000011 MAT:0000301 MESH:D003238 MIAA:0000301 OpenCyc:Mx4rv-aBgZwpEbGdrcN5Y29ycA TAO:0001641 UMLS:C0009780 VSAO:0000017 XAO:0001017 ZFA:0001632 galen:ConnectiveTissue portion of connective tissue textus connectivus uberon Bindegewebe UBERON:0002384 connective tissue UBERON:0002384 Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO] AAO:0000306 AEO:0000122 CALOHA:TS-0642 EHDAA2:0003122 EMAPA:32715 FMA:9641 MA:0002437 MESH:D009132 UMLS:C2328219 galen:MuscleTissue muscular tissue portion of muscle tissue textus muscularis uberon UBERON:0002385 Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. muscle tissue UBERON:0002385 Anatomical system that is involved in the production of hematopoietic cells. Anatomical system that consists of the blood and blood forming tissues.[AAO] Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG] hematopoietic In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes AAO:0011002 BTO:0000570 CALOHA:TS-0449 EFO:0000798 EMAPA:35402 EV:0100045 FMA:9667 GAID:1008 MA:0002434 MAT:0000022 MESH:D006413 MIAA:0000022 TAO:0005023 UMLS:C0018957 VHOG:0001624 XAO:0000122 ZFA:0005023 haematological system haemopoietic system organa haemopoietica uberon Blutbildungssystem haematopoietic system hematological system hematolymphoid system hemopoietic system UBERON:0002390 hematopoietic system UBERON:0002390 Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG] AAO:0011003 BILA:0000104 FMA:9825 GAID:328 MA:0002711 MESH:D007107 OpenCyc:Mx4rvWNkm5wpEbGdrcN5Y29ycA TAO:0001159 UMLS:C0020962 VHOG:0001247 XAO:0003152 ZFA:0001159 uberon UBERON:0002405 immune system UBERON:0002405 Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. (...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG] UBERON:0007029 AEO:0000154 BILA:0000118 CALOHA:TS-1299 CARO:0002001 EFO:0000807 EHDAA2:0000836 EHDAA2_RETIRED:0003154 EHDAA:6520 EMAPA:17524 EV:0100151 FBbt:00004969 FMA:72979 HAO:0000421 MA:0000014 MAT:0000033 MESH:D034582 MIAA:0000033 TADS:0000108 UMLS:C0037267 VHOG:0000403 XAO:0000176 galen:Surface integumentary system uberon body surface dermal system external covering of organism integumentum commune organism surface surface UBERON:0002416 integumental system UBERON:0002416 The abdominal segment of the torso. EMAPA:35104 FMA:259211 MA:0000021 uberon abdomen/pelvis/perineum lower body lower trunk lumbar region UBERON:0002417 abdominal segment of trunk UBERON:0002417 Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts. A type of dense connective tissue. It is composed of cells called chondrocytes which are dispersed in a firm gel-like ground substance, called the matrix. Cartilage is avascular (contains no blood vessels) and nutrients are diffused through the matrix. Cartilage is found in the joints, the rib cage, the ear, the nose, in the throat and between intervertebral disks. It makes up virtually the entire skeleton in chondrichthyes.[AAO] Portion of tissue which is connective tissue composed of collagen and/or elastin fibers and chondrocytes. Cartilage is avascular and provides both skeletal functions and a framework upon which bone is deposited.[TAO] Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.[VSAO] relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] Phylogenetic analysis suggests that cartilage arose independently in cnidarians, hemichordates, vertebrates, arthropods, annelids, brachiopods, and molluscs - or a common ancestor of brachiopods and molluscs (...). Analyses of cartilage as a tissue and of the development of invertebrate cartilages are consistent with homology between invertebrate and vertebrate cartilage. From the discussion above, it will be clear that understanding genetic changes underlying cartilage evolution is key to determining whether the multiple origins of cartilage represent parallel evolution.[well established][VHOG] AAO:0000060 AEO:0000087 BTO:0000206 EFO:0000949 EHDAA2:0003087 EMAPA:32730 EV:0100141 FMA:37377 GAID:99 MA:0000104 MAT:0000189 MESH:D002356 MIAA:0000189 OpenCyc:Mx4rvVjeOZwpEbGdrcN5Y29ycA TAO:0001501 UMLS:C0007301 VHOG:0001207 VSAO:0000040 XAO:0000170 ZFA:0005622 galen:Cartilage cartilage tissue cartilaginous tissue chondrogenic tissue uberon cartilage cartilages portion of cartilage tissue UBERON:0002418 Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W] cartilage tissue UBERON:0002418 A bone that is part of a limb [Automatically generated definition]. the formal definition is very inclusive, and includes sesamoids NCITA includes clavicle. MA:'limb bone' is actually a bone of limb or girdle EFO:0000945 MAT:0000151 MIAA:0000151 UMLS:C0582791 bone of extremity bone of limb free limb bone uberon UBERON:0002428 limb bone UBERON:0002428 Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot Naming conventions for pod terms under discussion within phenoscape group; note that this refers to the limb segment, not just the skeleton. autopod BTO:0004359 EFO:0000877 EMAPA:32722 FMA:83015 MA:0002714 MAT:0000091 MIAA:0000091 UMLS:C0687080 autopodial limb segment autopodial segment autopodium autopodium region distal free limb segment distal segment of free limb uberon autopodial element distal segment of limb manus/pes paw paw/hand/foot/hoof pod UBERON:0002470 autopod region UBERON:0002470 The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus). zeugopodial middle part of limb EFO:0000878 FMA:83016 MA:0002716 MAT:0000092 MIAA:0000092 epipodium middle free limb segment middle limb segment zeugopod limb segment zeugopodial limb segment zeugopodium zygopod zygopodium uberon middle segment of free limb UBERON:0002471 There exists some controversy about which podial segments are present in some fishes, e.g. if the autopod is not newly evolved in tetrapods, there is a question as to which segments are actually present in basal vertebrate taxa.[PHENOSCAPE:curators] zeugopod UBERON:0002471 The proximal free limb segment. Includes as parts the stylopod skeleton. stylopodial Naming conventions for pod terms under discussion within phenoscape group proximal part of limb EFO:0000879 FMA:83014 MA:0002717 MAT:0000093 MIAA:0000093 propodium proximal free limb segment stylopodial limb segment stylopodium uberon proximal segment of free limb UBERON:0002472 stylopod UBERON:0002472 Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. see https://github.com/obophenotype/uberon/issues/27 Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO] CALOHA:TS-2011 EMAPA:35179 FMA:224804 MA:0002780 MESH:D001842 UMLS:C0391978 VSAO:0000047 XAO:0004040 ZFA:0005621 galen:BoneTissue calcium tissue osseous tissue osteogenic tissue mineralized bone tissue uberon bone portion of bone tissue UBERON:0002481 bone tissue UBERON:0002481 Long bone is a limb bone that is subcylindrical and has a shaft with periosteum separating the ends of the bones. Long bones are present only in the limbs[VSAO:wd]. BTO:0004256 EMAPA:35503 FMA:7474 MA:0002802 OpenCyc:Mx4rv6axr5wpEbGdrcN5Y29ycA UMLS:C0222647 galen:LongBone uberon os longum UBERON:0002495 Endochondral_ossification is an essential process during the rudimentary formation of long bones, with the exception of the clavicle[Wikipedia:Endochondral_ossification]. The medial and and lateral ends undergo EO, the mid-portion is formed by a process with features of EO & IO (the process is shared by the mandible)[ISBN:9780397517251] long bone UBERON:0002495 Replacement bone that forms within cartilage. placement in this class to be inferred Replacement bone that forms within cartilage.[VSAO] some structures, e.g. in ZFA are both intramembrane and endochondral AAO:0010776 AEO:0000083 BTO:0002157 EHDAA2:0003083 FMA:24321 TAO:0001591 VSAO:0000145 XAO:0004018 ZFA:0001591 ossified chondrogenic bone uberon cartilaginous bone endochondral bones UBERON:0002513 endochondral bone https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern UBERON:0002513 A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles. TODO - align this with the CARO2 class 'appendage segment'; note the FMA class does not appear to require repetition FMA has both limb segment and free limb segment, the former includes the girdles. Note that MA uses the term more generally and includes A,S,Z,S+Z(arm/leg), whereas FMA is just A,S,Z FMA:241863 MA:0002889 UMLS:C1268195 free limb segment segment of limb subdivision of limb uberon extremity part limb region region of limb UBERON:0002529 limb segment UBERON:0002529 an organ that functions as a secretory or excretory organ glandular UBERON:MIAA_0000021 AAO:0000212 AEO:0000096 BTO:0000522 EFO:0000797 EHDAA2:0003096 EHDAA:2161 EHDAA:4475 EHDAA:6522 EMAPA:18425 FBbt:00100317 FMA:7146 FMA:86294 HAO:0000375 MA:0003038 MAT:0000021 MIAA:0000021 OpenCyc:Mx4rwP3vyJwpEbGdrcN5Y29ycA UMLS:C1285092 WikipediaCategory:Glands galen:Gland glandular organ uberon Druese glandula UBERON:0002530 gland UBERON:0002530 An outgrowth on the lateral trunk of the embryo that develops into a paired fin. The fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. Embryonic surface structure that develops into a paired fin.[ZFA] EFO:0003468 MAT:0000062 MIAA:0000062 TAO:0001383 VSAO:0000179 ZFA:0001383 fin bud fin buds uberon UBERON:0002531 paired fin bud UBERON:0002531 In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA] MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG] BTO:0004593 FMA:296704 MAT:0000067 MIAA:0000067 VHOG:0000243 epiblast uberon blastocyst ectoblast epiblastus primitive ectoderm UBERON:0002532 epiblast (generic) UBERON:0002532 Fin that is one of a pair located ventrally on the organism. TAO:0002278 VSAO:0000111 ZFA:0005596 artioptérygie@fr nageoire paire@fr pelvic/pectoral fin uberon UBERON:0002534 paired fin UBERON:0002534 A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans). this class represents the entire organism subdivision encompassing soft tissue as well as the underlying skeletal framework. The class represents the phalangeal part only - historically the term 'digit' has also been used to represent the unit consisting of a series of phalanges together with a metapodial bone. We may in future relabel this class to avoid confusion with this concept, but the class will continue to represent the phalangeal portion Our reinterpretation of the distal fin endoskeleton of Panderichthys removes the final piece of evidence supporting the formerly popular hypothesis that tetrapod digits are wholly new structures without homologues in sarcopterygian fish fins. This hypothesis, which was based partly on the complete absence of plausible digit homologues in Panderichthys (then the closest known relative of tetrapods), has already been called into question by the discovery of digit-like radials in Tiktaalik and the fact that Hox gene expression patterns closely resembling those associated with digit formation in tetrapods occur in the distal fin skeletons of paddlefish and Australian lungfish. Our new data show that Panderichthys is not an anomaly: like Tiktaalik and other fish members of the Tetrapodomorpha, it has distal radials that can be interpreted as digit homologues.[well established][VHOG] digital AAO:0011126 EFO:0000881 EMAPA:32725 FMA:85518 MA:0000690 MAT:0000285 MIAA:0000285 OpenCyc:Mx4rvzLD_ZwpEbGdrcN5Y29ycA UMLS:C0582802 VHOG:0000944 XAO:0003032 galen:Digit acropodial unit digit (phalangeal portion) plus soft tissue limb digit uberon UBERON:0002544 digit UBERON:0002544 Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. to avoid confusion, we include neurogenic placode as a subclass. Do not merge. Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons The term placode or placodes also applies to developing organs such as teeth, mammary glands, hair follicles, feathers and scales. We include a separate parent class for this. placode AAO:0010466 EFO:0001650 MAT:0000369 MIAA:0000369 XAO:0000305 uberon cranial placodes UBERON:0002546 cranial placode UBERON:0002546 Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. cavity FMA:67552 MA:0002447 galen:Cavity uberon UBERON:0002553 anatomical cavity UBERON:0002553 Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. FMA:55676 UMLS:C0445620 anatomical structure of brain biological structure of brain brain anatomical structure brain biological structure brain part neuraxis segment neuroanatomical region segment of brain uberon UBERON:0002616 regional part of brain UBERON:0002616 A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity. We conclude this section by listing some of the many synapomorphies of craniates, including (...) (2) neurogenic placodes (...).[well established][VHOG] AAO:0011076 EFO:0003420 EHDAA2:0001232 EHDAA:1504 EMAPA:16543 FMA:293971 TAO:0000048 VHOG:0000186 XAO:0000005 ZFA:0000048 olfactory placodes placoda nasalis placoda olfactoria uberon nasal I placode nasal placode UBERON:0003050 Olfactory placodes are the only ectodermal placodes to produce glia, a cell type typically derived from neural crest // Note that NBK53171 classifies this as non-neurogenic olfactory placode UBERON:0003050 The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. consider adding class for organizer. Consider adding separate class for isthmus as a structure Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG] AAO:0011064 DMBA:16810 EHDAA2:0004395 EHDAA:5789 EMAPA:32857 TAO:0000042 VHOG:0000649 XAO:0000016 ZFA:0000042 MHB mid-hindbrain boundary mid-hindbrain junction midbrain hindbrain boundary uberon isthmic organizer territory isthmo-cerebellar region isthmus isthmus/MHB UBERON:0003052 midbrain-hindbrain boundary UBERON:0003052 A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis. The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO] relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO] In mice, the first non-basal layer formed at ~E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo's physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at ~E17, when it is replaced by corneocytes[MP] In some mammals, Eyelid Fusion is thought to be driven by a population of cells which are derived from the periderm, the outermost layer of the developing epidermis Originally the epidermis is one layer thick, in most vertebrates it soon becomes a two-layered structure. The outer layer gives rise to the periderm. The periderm goes through distinct developmental phases and is ultimately sloughed into the amniotic fluid when differentiation of the underlying epidermal layers is complete. The function of the periderm is not known, but is thought to be related to transport/exchange between the fetus and the amniotic fluid (http://courses.washington.edu/hubio567/devbio/periderm.html) EHDAA2:0001846 EHDAA:6538 FMA:295662 TAO:0001185 UMLS:C1518973 VHOG:0001680 XAO:0000029 ZFA:0001185 skin periderm uberon EVL epidermis epithelial layer epidermis outer layer epitrichium periderm UBERON:0003055 periderm UBERON:0003055 The portion of neural plate anterior to the mid-hindbrain junction. (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0011084 TAO:0007016 VHOG:0001200 XAO:0000045 ZFA:0007016 uberon anterior neural plate UBERON:0003056 pre-chordal neural plate UBERON:0003056 The portion of neural plate posterior to the mid-hindbrain junction. (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] TAO:0007017 VHOG:0001201 XAO:0000046 ZFA:0007017 uberon posterior neural plate UBERON:0003057 chordal neural plate UBERON:0003057 Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] AAO:0011086 EFO:0001982 EMAPA:16189 EMAPA:16752 TAO:0000279 VHOG:0000559 XAO:0000057 ZFA:0000279 segmental plate unsegmented paraxial mesoderm uberon PSM presumptive somite mesoderm somitogenic mesoderm somitomeric mesoderm unsegmented mesenchyme UBERON:0003059 presomitic mesoderm UBERON:0003059 Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO] Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO] relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO] Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG] EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac ventral lateral plate mesoderm AAO:0011006 EFO:0003489 EHDAA:207 TAO:0000094 TE:E5.11.2.0.0.0.4 UMLS:C1511224 VHOG:0000085 XAO:0000067 ZFA:0000094 blood islands uberon VBI caudal hematopoietic tissue posterior ICM posterior blood island ventral blood island UBERON:0003061 blood island UBERON:0003061 The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] AAO:0011017 EFO:0003647 TAO:0001204 VHOG:0000107 XAO:0000205 ZFA:0001204 uberon chordamesoderm UBERON:0003068 axial mesoderm UBERON:0003068 A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0011072 BTO:0001765 DHBA:10153 DMBA:15565 EHDAA:346 EHDAA:902 EMAPA:35593 FMA:293879 RETIRED_EHDAA2:0001252 TAO:0000132 UMLS:C0920623 VHOG:0000068 XAO:0000249 ZFA:0000132 uberon lamina neuralis presumptive central nervous system UBERON:0003075 neural plate UBERON:0003075 (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0011082 TAO:0007037 VHOG:0001383 XAO:0000250 ZFA:0007037 uberon UBERON:0003076 posterior neural tube UBERON:0003076 The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO] Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here) AAO:0010568 EFO:0003515 EMAPA:16183 EMAPA:16751 FMA:293145 TAO:0000255 UMLS:C1284009 VHOG:0000114 XAO:0000259 ZFA:0000255 paraxial mesenchyme somitic mesoderm uberon mesoderma paraxiale UBERON:0003077 paraxial mesoderm UBERON:0003077 TODO - add grouping class for the anterior end of the neural tube at all stages (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] AAO:0011012 TAO:0007038 VHOG:0001384 XAO:0000307 ZFA:0007038 uberon UBERON:0003080 anterior neural tube UBERON:0003080 Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO] The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] subclass of mesoderm in ZFA. UBERON:0006258 AAO:0010574 EHDAA2:0000919 EHDAA:379 EMAPA:16179 FMA:293149 TAO:0000121 UMLS:C1517749 VHOG:0000118 XAO:0000311 ZFA:0000121 LPM lateral mesoderm uberon lateral plate lateral plate mesenchyme mesoderma laminae lateralis UBERON:0003081 lateral plate mesoderm UBERON:0003081 A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells. The term 'myotome' is also used to describe the muscles served by a single nerve root / spinal segment - consider adding new class, myomere. Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO] In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG] AAO:0011067 AEO:0001018 BTO:0000742 EHDAA2_RETIRED:0003431 EHDAA:1721 EHDAA:1727 EHDAA:1733 EHDAA:1739 EMAPA:32841 FMA:295658 TAO:0001056 UMLS:C1513802 VHOG:0001244 XAO:0000315 ZFA:0001056 myomeres uberon muscle plate myomere myotome region myotomes myotomus UBERON:0003082 myotome UBERON:0003082 Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. should probably be merged with heart rudiment. Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO] relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO] AAO:0011044 BTO:0001887 TAO:0000028 UMLS:C1514450 XAO:0000336 ZFA:0000028 uberon cardiac field fused heart primordium UBERON:0003084 heart primordium UBERON:0003084 Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. Skeletogenic portion of somites.[AAO] The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] part_of somite in XAO AAO:0010571 AEO:0000212 EHDAA2:0003439 EMAPA:31159 FMA:295652 TAO:0001080 UMLS:C0183176 VHOG:0000680 XAO:0000397 ZFA:0001080 sclerotomes uberon sclerotomus UBERON:0003089 sclerotome UBERON:0003089 neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. Anterior most portion of the neural crest. Migrates in three highly conserved streams: mandibular, hyoid and branchial.[AAO] Neural crest that is part of the head.[TAO] We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] AAO:0010580 EFO:0003645 EHDAA2:0004420 EMAPA:16091 TAO:0001194 VHOG:0000063 XAO:0001001 ZFA:0001194 CNC cephalic neural crest cranial NCC population head NCC population uberon crista neuralis cranialis head crest head neural crest UBERON:0003099 cranial neural crest UBERON:0003099 Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA] AAO:0010337 AEO_RETIRED:0000010 EHDAA2_RETIRED:0003010 TAO:0000292 VSAO:0000001 XAO:0003028 ZFA:0000292 galen:SurfaceRegion anatomical surface feature uberon surface feature surface region surface structures UBERON:0003102 surface structure UBERON:0003102 Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs AAO:0010015 AEO:0000024 BILA:0000024 CARO:0000024 EHDAA2:0003024 HAO:0000024 TADS:0000598 TAO:0000496 TGMA:0001837 VHOG:0001723 XAO:0003041 ZFA:0000496 uberon organ UBERON:0003103 compound organ UBERON:0003103 Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage[XAO]. A mesh-like cell arrangement, less compact than an epithelium[ZFA]. The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop[BTO]. the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO] Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO] mesenchymal AAO:0010427 AEO:0000145 BTO:0001393 CALOHA:TS-0620 EHDAA2:0003145 EV:0100007 TAO:0000393 UMLS:C0162415 VHOG:0000170 XAO:0003046 ZFA:0000393 mesenchymal tissue mesenchyme tissue portion of mesenchymal tissue portion of mesenchyme tissue uberon mesenchyma UBERON:0003104 mesenchyme UBERON:0003104 Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits. phalangeal In primates such as humans and monkeys, the thumb and big toe have two phalanges, while the other fingers and toes consist of three CALOHA:TS-2211 EMAPA:32614 FMA:321661 MA:0000304 OpenCyc:Mx4rvolPZpwpEbGdrcN5Y29ycA UMLS:C0222682 VSAO:0000199 galen:Phalanx digit long bone long bone of digit phalange phalanges phalanx bone uberon UBERON:0003221 phalanx UBERON:0003221 An endoderm that is part of a foregut [Automatically generated definition]. TODO - check EHDAA2:0004568 EHDAA:524 foregut endoderm uberon UBERON:0003258 endoderm of foregut UBERON:0003258 A long bone that is part of a limb [Automatically generated definition]. EMAPA:35495 MA:0000298 long bone of limb uberon UBERON:0003606 limb long bone UBERON:0003606 Any joint that is part of a (free) limb. EMAPA:36501 FMA:321558 MA:0000691 galen:LimbJoint joint of limb joint of limb skeletal system skeletal limb joint uberon UBERON:0003657 Most limb joints are synovial, but a few such as the tibiofibular joints are syndesmoses limb joint UBERON:0003657 Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO] FMA definition includes vasculature AAO:0000325 AEO:0000123 EHDAA2:0003123 FMA:9642 GAID:609 MESH:D009417 OpenCyc:Mx4rVmfYCsQ_QdeM_bFAeS8NRQ UMLS:C0027757 nerve tissue nervous tissue portion of neural tissue uberon UBERON:0003714 neural tissue UBERON:0003714 A bone of the metapodial skeleton MA:0000301 metacarpal or metatarsal bone metacarpal/metatarsal metacarpal/metatarsal bone metapodi bone metapodial bone metapodium bone uberon UBERON:0003821 metapodium bone UBERON:0003821 A limb joint that is part of an autopod [Automatically generated definition]. EMAPA:35160 MA:0002715 autopod joint of limb autopod limb joint distal free limb segment joint of limb distal free limb segment limb joint joint of limb of autopod joint of limb of distal free limb segment limb joint of autopod limb joint of distal free limb segment uberon paw joint UBERON:0003841 autopod joint UBERON:0003841 An anatomical space that surrounded_by a neural tube. (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] UBERON:0005713 AAO:0011073 EHDAA2:0001269 EHDAA:2889 EHDAA:914 EMAPA:16167 EMAPA:16533 VHOG:0001119 XAO:0000252 cavity of neural tube lumen of neural tube neural tube neural lumen prosencoel uberon central lumen neural lumen neurocoel UBERON:0003842 neural tube lumen UBERON:0003842 A neural crest that has_potential_to_developmentally_contribute_to a midbrain. We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] EFO:0003591 EHDAA2:0001101 EHDAA:360 TAO:0000935 VHOG:0000796 ZFA:0000935 mesencephalic neural crest neural crest midbrain uberon UBERON:0003849 mesencephalic neural crest UBERON:0003849 A neural crest that has_potential_to_developmentally_contribute_to a telencephalon. Cranial neural crest that is part of the telencephalon.[TAO] We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] EFO:0003574 RETIRED_EHDAA2:0001991 TAO:0000812 VHOG:0000799 ZFA:0000812 neural crest telencephalon uberon UBERON:0003850 telencephalon neural crest UBERON:0003850 A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. Cranial neural crest that is part of the hindbrain.[TAO] We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] EHDAA2:0001628 EHDAA:362 EMAPA:35747 TAO:0007063 VHOG:0001210 ZFA:0007063 neural crest hindbrain rhombencephalic neural crest uberon rhombomere neural crest UBERON:0003852 rhombencephalon neural crest UBERON:0003852 A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...)[well established][VHOG] EHDAA:696 EMAPA:16163 EMAPA:16529 EMAPA:16881 VHOG:0001006 neural crest spinal cord uberon spinal neural crest UBERON:0003853 spinal cord neural crest UBERON:0003853 A presumptive structure that has the potential to develop into a ganglion. uberon UBERON:0003869 presumptive ganglion UBERON:0003869 An anatomical cavity that has the potential to develop into a coelemic cavity lumen. uberon body cavity precursor UBERON:0003886 future coelemic cavity lumen UBERON:0003886 The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] EHDAA:251 EMAPA:16088 UMLS:C1512940 VHOG:0000316 somatic coelom uberon UBERON:0003887 intraembryonic coelom UBERON:0003887 Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. contrast with a multi-tissue tube, which has as parts both epithelium, connective tissue, possibly muscle layers AEO:0000114 EHDAA2:0003114 FBbt:00007474 epithelial or endothelial tube uberon UBERON:0003914 epithelial tube UBERON:0003914 An epithelium that lines the lumen of the digestive tract. Epithelium lining the lumen of the gut.[TAO] BTO:0000956 EHDAA2:0004567 EMAPA:32928 MA:0003201 TAO:0005123 UMLS:C0836205 XAO:0003200 ZFA:0005123 digestive tract epithelial tissue epithelial tissue of digestive tract epithelial tissue of gut epithelium of digestive tract epithelium of gut gastrodermis gut epithelial tissue gut epithelium uberon alimentary tract epithelium UBERON:0003929 digestive tract epithelium UBERON:0003929 A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. Not to be confused with 'dermatome segment of skin'. AAO:0011028 AEO:0001017 EHDAA2_RETIRED:0003428 EHDAA:1719 EHDAA:1725 EHDAA:1731 EHDAA:1737 EMAPA:32838 FMA:295656 UMLS:C0180383 XAO:0000220 cutis plate dermatomal mesenchyme uberon epimere mesoderm mesenchyma dermatomiale UBERON:0004016 dermatome UBERON:0004016 The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells As the cells adjacent to the lumen continue to divide, the migrating cells form a second layer around the original neural tube. This layer becomes progressively thicker as more cells are added to it from the germinal neuroepithelium. This new layer is called the mantle (or intermediate) zone, and the germinal epithelium is now called the ventricular zone (and, later, the ependyma)[NCBIBook:NBK10047] germinal neuroepithelial layer germinal neuroepithelium original neural tube uberon UBERON:0004022 germinal neuroepithelium UBERON:0004022 The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure The layer of undifferentiated, proliferating cells that line the neural tube lumen ependymal layer EMAPA:17152 EMAPA:35362 EMAPA_RETIRED:16783 MA:0003193 neural tube ependymal layer neural tube ventricular germinal zone neural tube ventricular zone neural tube ependymal zone uberon UBERON:0004060 neural tube ventricular layer UBERON:0004060 The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. EMAPA:17148 EMAPA:35360 neural tube intermediate zone uberon future brain marginal layer UBERON:0004061 neural tube mantle layer UBERON:0004061 The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter EMAPA:17151 neural tube marginal zone uberon brain marginal zone UBERON:0004062 neural tube marginal layer UBERON:0004062 2 2 Any tube, opening or passage that connects two distinct anatomical spaces. FMA has both conduit and conduit space. In EHDAA2 this is a surface feature AEO:0000080 EHDAA2:0003080 FMA:242873 foramen foramina uberon opening ostia ostium UBERON:0004111 anatomical conduit UBERON:0004111 An anatomical structure that develops (entirely or partially) from the endoderm. Grouping term for query purposes uberon UBERON:0004119 endoderm-derived structure UBERON:0004119 An anatomical structure that develops (entirely or partially) from the mesoderm. Grouping term for query purposes uberon UBERON:0004120 mesoderm-derived structure UBERON:0004120 An anatomical structure that develops (entirely or partially) from the ectoderm. Grouping term for query purposes uberon UBERON:0004121 ectoderm-derived structure UBERON:0004121 The first recognizable structure derived from the heart field TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO (In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG] EHDAA2:0000215 EMAPA:16106 VHOG:0000975 myocardial plate uberon cardiac crescent cardiogenic crescent heart rudiment UBERON:0004139 cardiogenic plate UBERON:0004139 A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] XAO:0004185 first heart field primary heart field uberon FHF PHF heart field UBERON:0004140 primary heart field UBERON:0004140 An epithelial tube that will give rise to the mature heart. the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube. AAO:0010411 EFO:0003526 EMAPA:32685 TAO:0000360 XAO:0000337 ZFA:0000360 embryonic heart tube endocardial heart tube endocardial tube uberon UBERON:0004141 heart tube UBERON:0004141 A cardiac chamber surrounds an enclosed cavity within the heart FMA:7095 OpenCyc:Mx4rmexpjPdAEduAAAAOpmP6tw chamber of heart heart chamber uberon UBERON:0004151 generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus cardiac chamber UBERON:0004151 Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO] skeletal AEO:0000168 EHDAA2:0001843 EHDAA:5047 EMAPA:17213 FMA:23875 GAID:177 MA:0003006 MAT:0000032 MESH:D012863 MIAA:0000032 OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA VSAO:0000026 XAO:0004053 galen:Skeleton set of all bones set of bones of body uberon UBERON:0004288 skeleton https://github.com/obophenotype/uberon/wiki/The-skeletal-system UBERON:0004288 The bilaminar epithelium formed from the myotome and dermatome. Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]. Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO] Portion of somites that gives rise to dermis and muscles.[AAO] all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis. Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG] AAO:0010572 AEO:0000214 EHDAA2:0003259 EMAPA:31109 FMA:295654 TAO:0001513 UMLS:C1511786 VHOG:0000676 ZFA:0001513 uberon dermamyotome dermomyotomes UBERON:0004290 dermomyotome UBERON:0004290 A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO] TAO:0000115 ZFA:0000115 heart cone rudimentary heart uberon UBERON:0004291 heart rudiment UBERON:0004291 Distal-most phalanx within a digit. In human anatomy, the distal phalanges of the four fingers and toes articulate proximally with the intermediate phalanges at the distal interphalangeal joints (DIP); in the thumb and big toe, with only two phalanges, the distal phalanges articulate proximally with the proximal phalanges. The distal phalanges carry and shape nails and claws and are therefore occasionally referred to as the ungual phalanges. The distal phalanges are cone-shaped in most mammals, including most primates, but relatively wide and flat in humans. AAO:0010676 EMAPA:35287 MA:0002914 phalanx distalis terminal phalanx ungual phalanx uberon phalanx distalis UBERON:0004300 distal phalanx UBERON:0004300 A phalanx located between proximal and distal phalanges. consider using numbering system, and axioms to the effect that there is a single middle phalanx per finger in humans. This should perhaps be renamed 'intermediate phalanx', leaving the term middle phalanx open for the specific intermediate phalanx of a 3-phalanx digit Intermediate phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones of the finger and toe which lie in the middle, between the two wrinkly joints. The thumb and big toe do not have intermediate phalanges. In most other vertebrates, they have a corresponding place in their limbs, whether they be paw, wing, hoof or fin in some groups such as whales, there are multiple intermediate phalanges AAO:0010677 EMAPA:35572 MA:0002915 intermediate phalanx uberon medial phalanx penultimate phalanx phalanx 2 phalanx II UBERON:0004301 middle phalanx UBERON:0004301 Proximal-most phalanx within a digit. Proximal phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones at the base of a toe or finger, the prominent, knobby ends of which are often called the knuckles. In other vertebrates, proximal phalanges have a similar placement in the corresponding limbs, be they paw, wing or fin. In many species, they are the longest and thickest phalanx ('finger' bone) 1 AAO:0010680 EMAPA:35716 MA:0002916 phalanx 1 phalanx I proximal-most phalanx uberon UBERON:0004302 proximal phalanx UBERON:0004302 An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. Early outgrowth of presumptive limb.[AAO] AAO:0010375 BTO:0001640 EMAPA:35944 FMA:296780 GAID:1307 MESH:A16.254.462 UMLS:C0282505 XAO:0003161 limb buds limbbud uberon gemmae membrorum UBERON:0004347 developmentally_induced_by Fgf10, capable of initiating limb forming interactions between endoderm and mesoderm limb bud UBERON:0004347 multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. note that media, dorsal fins etc have AERs. Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO] Proliferative region that is part of the developing fin fold or fin.[TAO] relationship loss: subclass proliferative region (TAO:0000098)[TAO] The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop AAO:0010760 EMAPA:32744 TAO:0002146 UMLS:C1516037 XAO:0004121 ZFA:0001702 apical epidermal ridge uberon AER crista ectodermalis apicalis UBERON:0004356 apical ectodermal ridge UBERON:0004356 An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. The tetrapod limb is derived from a posterior part of the fin endoskeleton of elasmobranchs and basal bony fish, the so-called metapterygium, a series of endoskeletal elements that is the first to form in the developing paired fins. (...) In addition, there is an independent endoskeletal element called the protopterygium that develops anterior to the metapterygium in many basal fishes (e.g., the bichir and sturgeon). Teleosts have lost the metapterygium whereas the sarcopterygians, on the other hand, have lost the protopterygium. Sarcopterygians thus develop all their endoskeletal structures from the metapterygium and consequently the tetrapod limb skeleton is derived from the metapterygium.[uncertain][VHOG] VHOG:0001258 limb - fin bud paired appendage bud paired limb/fin bud uberon UBERON:0004357 Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056] paired limb/fin bud UBERON:0004357 A bone that is part of an appendage [Automatically generated definition]. appendage bone bone of appendage bone of free segment of appendicular skeleton uberon UBERON:0004375 bone of free limb or fin UBERON:0004375 The collection of all skeletal elements in an individual limb. Skeletal subdivision that is part of the limb.[VSAO] EHDAA2 considers hip and shoulder joints part of limb skeleton. EHDAA2:0002221 EMAPA:32702 VSAO:0000300 free limb skeleton limb skeleton set of bones of limb uberon UBERON:0004381 skeleton of limb UBERON:0004381 Sum of all sensory systems in an organism. note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs FMA:78499 sense organ system uberon UBERON:0004456 entire sense organ system UBERON:0004456 A projection or outgrowth of tissue from a larger body or organ. should be declared disjoint from organ, but in some ontologies (e.g. ZFA), structures such as neural spines are classified as bones (and hence organs) Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, or tissue.[AAO] Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, tissue, fin, scale, etc.[TAO] Anatomical structure that is a natural outgrowth, projection, or appendage. A process can be part of a bone, cartilage, tissue, fin, scale, etc.[VSAO] anatomical process process AAO:0010278 FMA:67601 HAO:0000822 TAO:0001834 VSAO:0000180 XAO:0004020 galen:Ridge processus projection flange flanges lamella lamellae lamina laminae organ process papilla process of organ processes projection projections ridge ridges shelf shelves uberon anatomical protrusion protrusion spine UBERON:0004529 anatomical projection UBERON:0004529 Anatomical system that has as its parts the heart and blood vessels. we treat cardiovascular as part of circulatory system, with the latter including other kinds of circulation, including lymph. The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG] AAO:0011001 BILA:0000016 BTO:0000088 CALOHA:TS-1297 EFO:0000791 EHDAA2:0000216 EHDAA:394 EMAPA:16104 EMAPA:16370 EV:0100017 FMA:7161 GAID:467 MA:0000010 MAT:0000016 MESH:D002319 MIAA:0000016 OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA TAO:0000010 UMLS:C0007226 VHOG:0000302 WikipediaCategory:Cardiovascular_system XAO:0000100 XAO:0001010 ZFA:0000010 uberon CV system Herz und Gefaesssystem UBERON:0004535 cardiovascular system UBERON:0004535 A vascular network consisting of blood vessels. TAO:0001079 ZFA:0001079 blood vascular network set of blood vessels uberon blood system blood vessel system blood vessels UBERON:0004537 blood vasculature UBERON:0004537 An appendage that is part of a appendage girdle complex. this class is the union of the classes limb, pectoral fin and pelvic fin. UBERON:0009872 VSAO:0000067 girdle-associated appendage limb or fin limb/fin pectoral or pelvic appendage pelvic/pectoral appendage jointed paired lateral appendage paired appendage uberon UBERON:0004708 paired limb/fin UBERON:0004708 The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. EHDAA2 places this as a subtype of organism. This leads to the inference that a conceptus is an embryo (if an embryo is defined as an organism at embryo stage), which eliminates the embryonic + extra-embryonic = conceptus AEO:0000194 BTO:0003834 EHDAA2:0000001 EHDAA2:0003235 EMAPA:36040 UMLS:C1516779 embryo plus adnexa uberon UBERON:0004716 conceptus UBERON:0004716 Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. revisit this after CARO is revised and/or we have defined metameric segment; note that with the additional of an A/P axis constraint this corresponds to what Richter at al call a neuromere (PMID:21062451) FBbt:00005140 uberon neuromere UBERON:0004732 segmental subdivision of nervous system UBERON:0004732 An organ subunit that is part of a hindbrain [Automatically generated definition]. FMA:61998 hindbrain segment segment of hindbrain uberon UBERON:0004733 segmental subdivision of hindbrain UBERON:0004733 Organism at the gastrula stage. We explicitly merge the NCITA terms here UBERON:0007012 BILA:0000060 BTO:0001403 FBbt:00005317 FMA:293108 GAID:1302 MESH:A16.254.412 MIAA:0000179 UMLS:C0017199 UMLS:C1284022 gastrula embryo uberon blastocystis trilaminaris tri-laminar disc tri-laminar disk trilaminar blastocyst trilaminar blastoderm trilaminar disc trilaminar disk trilaminar germ UBERON:0004734 gastrula UBERON:0004734 A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] MA:0003047 VSAO:0000015 XAO:0004038 ZFA:0005619 uberon UBERON:0004755 Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from skeletal tissue UBERON:0004755 Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] AAO:0011129 TAO:0001890 VSAO:0000128 XAO:0004012 ZFA:0005494 galen:SkeletalStructure uberon UBERON:0004765 skeletal element UBERON:0004765 Anatomical system that consists of all the joints of the body. EMAPA:35150 FMA:23878 MA:0003007 VSAO:0000181 joint system set of all joints of body uberon set of all joints set of joints of body UBERON:0004770 articular system UBERON:0004770 Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. We group the BILA class here. Considering adding more general class for metazoa grouping cardiogenic successors visceral mesoderm AAO:0011102 BILA:0000044 FMA:295568 XAO:0000276 inner layer of lateral plate mesoderm uberon splanchnic mesoderm UBERON:0004872 splanchnic layer of lateral plate mesoderm UBERON:0004872 The central region of trunk mesoderm. This tissue forms the notochord Notochord rudiment[ZFIN:ZDB-PUB-961014-576]. WP treats this as synonym of axial mesoderm. Induces neural tube. Gilbert: contains an anterior head process and the notochord. AAO:0000478 EFO:0003426 TAO:0000091 ZFA:0000091 axial chorda mesoderm chorda mesoderm dorsal mesoderm presumptive notochord uberon UBERON:0004880 chordamesoderm UBERON:0004880 Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts. FBbt:00005811 joint uberon UBERON:0004905 articulation UBERON:0004905 A proximal-distal subdivision of the digestive tract. intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct. FBbt:00100315 FMA:71131 uberon alimentary system subdivision intestinal tract segment of intestinal tract subdivision of alimentary system UBERON:0004921 subdivision of digestive tract UBERON:0004921 A part of a wall of an organ that forms a layer. FMA:82485 uberon UBERON:0004923 organ component layer UBERON:0004923 The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]. AAO:0011071 EMAPA:35594 FMA:295624 UMLS:C0814992 XAO:0000248 uberon UBERON:0005061 neural groove UBERON:0005061 One of the two elevated edges of the neural groove[GO,MP]. In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]. EHDAA2:0001249 EMAPA:16142 EMAPA:16146 EMAPA:16151 EMAPA:16155 EMAPA:16159 EMAPA:16162 EMAPA:16288 EMAPA:16292 EMAPA:16295 EMAPA:16299 EMAPA:16303 EMAPA:16307 EMAPA:16528 FMA:295618 UMLS:C0814993 XAO:0004087 medullary fold uberon UBERON:0005062 neural fold UBERON:0005062 A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube. Kimmel et al, 1995.[TAO] EFO:0003498 TAO:0000133 ZFA:0000133 uberon neural tube rod UBERON:0005068 neural rod UBERON:0005068 An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO] consder adding placodal ectoderm as a distinct class? Also place placodal ectoderm as develops_from ectoderm; need to check taxon-appropriateness With the exception of the adenohypophysis, homologues of the nonneurogenic placodes (e.g. placodes giving rise to the teeth, hair follicles and lens), appear to be lacking in invertebrate chordates. in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous. AEO:0000218 FMA:293966 uberon epithelial placode UBERON:0005085 ectodermal placode UBERON:0005085 Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. in some organisms such as drosophila, muscles can be single cells. This class groups together all discrete muscle elements, from multicellular muscle organs in vertebrates, to individual single-cell muscles in drisophila EMAPA:32715 FBbt:00005073 FMA:30316 musculus uberon muscle muscle element UBERON:0005090 muscle structure UBERON:0005090 A bud is a protrusion that forms from an epithelial sheet by localized folding. BTO:0001639 uberon UBERON:0005153 epithelial bud UBERON:0005153 An epithelial sheet bent on a linear axis. uberon UBERON:0005157 epithelial fold UBERON:0005157 A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.' AAO:0011000 CARO:0001000 FBbt:00007060 FMA:83115 multi-cell-component structure multi-cell-part structure uberon cell part cluster UBERON:0005162 multi cell part structure UBERON:0005162 An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. MA:0001901 back organ dorsal region organ uberon UBERON:0005174 dorsal region element UBERON:0005174 An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. MA:0000516 trunk organ uberon UBERON:0005177 trunk region element UBERON:0005177 An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. MA:0000557 thoracic cavity organ uberon UBERON:0005178 thoracic cavity element UBERON:0005178 An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. MA:0000563 uberon upper body organ UBERON:0005181 thoracic segment organ UBERON:0005181 Mesenchyme that is part of a developing trunk. EFO:0003485 EHDAA2:0002092 EHDAA:377 EMAPA:16177 TAO:0000081 VHOG:0000281 ZFA:0000081 uberon trunk and cervical mesenchyme UBERON:0005256 trunk mesenchyme UBERON:0005256 The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG] The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] the terms metencephalon and myelencephalon are only meaningful in mammals and birds - Neuroanatomy of the Zebrafish Brain. Note that its not clear if this refers to the developing medulla oblongata - MA (adult) has two distinct classes BTO:0000758 CALOHA:TS-0607 CALOHA:TS-2365 DHBA:10662 EHDAA2:0001207 EHDAA:5526 EMAPA:17082 HBA:9512 MA:0000205 VHOG:0000456 uberon myelencephalon (medulla oblongata) UBERON:0005290 myelencephalon UBERON:0005290 A portion of tissue that is part of an embryo. CALOHA:TS-2100 portion of embryonic tissue uberon developing tissue UBERON:0005291 embryonic tissue UBERON:0005291 The part of the digestive system that excludes the hepatobiliary system. the decision to split digestive and gastrointestinal in this way may be revisited. As it currently stands, this class more closely aligns what MA calls the alimentary system The system that includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas[ncithesaurus:Gastrointestinal_System]. All metazoans (with degenerate exceptions) have some sort of digestive cavity with a means of entrance to and exit from it.[well established][VHOG] that many anatomy ontologies consider this synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class. We have one entity that is part of both gastrointestinal and hepatobiliary systems: hepatopancreatic ampulla. BTO:0000058 CALOHA:TS-0407 EHDAA2:0000110 EHDAA:514 EMAPA:16246 EV:0100056 FMA:71132 GAID:294 MA:0000323 MESH:A03.492 UMLS:C0012240 VHOG:0000412 galen:GastrointestinalTract uberon GI tract alimentary system alimentary tract gastro-intestinal system gastrointestinal (GI) tract gastrointestinal system gastrointestinal tract UBERON:0005409 alimentary part of gastrointestinal system UBERON:0005409 AEO:0000125 CALOHA:TS-2122 EHDAA2:0003125 FBbt:00007006 FMA:292313 MIAA:0000019 uberon developing structure developmental structure developmental tissue UBERON:0005423 developing anatomical structure UBERON:0005423 In the early gastrula of vertebrates, factors from the organizer (e.g. noggin, chordin, and follistatin in Xenopus) antagonize the epidermalizing factor bone morphogenetic protein 4 (BMP4), thus dividing the epiblast into neuroectoderm. In Drosophila, decapentaplegic, the homologue of BMP4, interacts similarly with the protein short gastrulation, the homologue of chordin. Thus, a comparable molecular mechanism for distinguishing non-neural ectoderm from neural ectoderm was probably present in the common ancestor of all bilaterally symmetrical animals.[well established][VHOG] After gastrulation, neural crest cells are specified at the border of the neural plate and the non-neural ectoderm. EFO:0003643 EHDAA:257 EMAPA:16074 RETIRED_EHDAA2:0001273 TAO:0001178 VHOG:0001372 XAO:0004091 ZFA:0001178 non neural ectoderm epidermal ectoderm epithelial ectoderm uberon surface ectoderm ventral ectoderm UBERON:0005497 Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). Editor note: todo - epidermis? todo - track down EHDAA2 class in new release non-neural ectoderm UBERON:0005497 Multi-tissue structure that arises from the heart rudiment and will become the heart tube. EHDAA2:0001512 EHDAA:424 EHDAA:436 EMAPA:16208 EMAPA:16215 FMA:321916 TAO:0000149 ZFA:0000149 primitive heart tube early primitive heart tube uberon UBERON:0005498 primitive heart tube UBERON:0005498 A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum. UBERON:3010717 AAO:0011059 EFO:0002578 EMAPA:36007 XAO:0001002 uberon lateral diverticula lung diverticulum lung endoderm UBERON:0005597 lung primordium UBERON:0005597 A sensory system that is capable of olfacttion (the sensory perception of smell). consider splitting into main and accessory. See also: vomeronasal organ we make the relationship to nervous system 'overlaps', as the olfactory system includes e.g. apertures in the cranium that are not part of the nervous system The olfactory system is the sensory system used for olfaction, or the sense of smell. Most mammals and reptiles have two distinct parts to their olfactory system: a main olfactory system and an accessory olfactory system. The main olfactory system detects volatile, airborne substances, while the accessory olfactory system senses fluid-phase stimuli. Behavioral evidence indicates that most often, the stimuli detected by the accessory olfactory system are pheromones. The olfactory system is often spoken of along with the gustatory system as the chemosensory senses because both transduce chemical signals into perception[WP][Wikipedia:Olfactory_system]. The sensory system used for olfaction (the sense of smell).[AAO] In mammals, the main olfactory system detects odorants that are inhaled through the nose, where they contact the main olfactory epithelium, which contains various olfactory receptors. These olfactory receptors are membrane proteins of bipolar olfactory receptor neurons in the olfactory epithelium. Rather than binding specific ligands like most receptors, olfactory receptors display affinity for a range of odor molecules. Olfactory neurons transduce receptor activation into electrical signals in neurons. The signals travel along the olfactory nerve, which belongs to the peripheral nervous system. This nerve terminates in the olfactory bulb, which belongs to the central nervous system. The complex set of olfactory receptors on different olfactory neurons can distinguish a new odor from the background environmental odors and determine the concentration of the odor[WP]. AAO:0000334 AAO:0000978 BILA:0000144 EFO:0001973 EMAPA:36004 FMA:7190 MA:0002445 OpenCyc:Mx4rvViw75wpEbGdrcN5Y29ycA TAO:0001149 UMLS:C0228065 XAO:0003196 ZFA:0001149 uberon UBERON:0005725 olfactory system UBERON:0005725 BILA:0000139 uberon UBERON:0005726 chemosensory system UBERON:0005726 A limb/fin field that has_potential_to_developmentally_contribute_to a paired fin bud. fin field of lateral plate mesoderm uberon UBERON:0005731 fin field UBERON:0005731 A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. we represent the field as being a part of the LPM (consistent with ZFA, Gilbert). As a consequence, the relationship between limb bud (with is ectoderm+mesenchyme) stands in a weaker has_developmental_contribution_from relation to the field - TODO implement this. limb/fin field of lateral plate mesoderm paired limb/fin field uberon UBERON:0005732 paired limb/fin field UBERON:0005732 A ring of cells capable of forming a limb. limb field of lateral plate mesoderm uberon UBERON:0005733 the central portion of the limb field gives rise to the limb proper. mesenchyme cells proliferate from from the somatic layer of limb field lateral plate mesoderm (limb skeletal precursors) and from the somites (limb muscle precursors) . these mesenchymal cells accumulate under the ectedermal tissue to make a limb bud. // The lateral plate mesoderm in the limb field is also special in that it will induce myoblasts to migrate out from the somites and enter the limb bud. No other region of the lateral plate mesoderm will do that (Hayashi and Ozawa 1995) limb field UBERON:0005733 A acellular anatomical structure that is the bounding layer of a anatomical structure. FMA:63871 uberon UBERON:0005764 acellular membrane UBERON:0005764 An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. this class represents a continuous sheet of basement membrane which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal membrane' represents a portion of substance on the scale of a single cell. AAO:0010596 FMA:63872 GAID:915 UMLS:C0004799 basement membrane of connective tissue membrana basalis uberon basement membrane UBERON:0005769 basement membrane of epithelium UBERON:0005769 A delimited region of dense mesenchyme within looser mesenchyme. AEO:0000148 EHDAA2_RETIRED:0003148 EHDAA:8979 mesenchyme condensation uberon UBERON:0005856 developing mesenchymal condensation UBERON:0005856 Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes. isa cell condensation in VSAO; has_part chondroblast in AEO AEO:0000147 EHDAA2_RETIRED:0003147 EMAPA:32731 VSAO:0000092 XAO:0004022 cartilage condensation cartilagenous condensation chondrogenic condensation uberon UBERON:0005863 cartilaginous condensation UBERON:0005863 A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts. A closely packed aggregation of mesenchymal cells just prior to their differentiation into embryonic cartilage. AEO:0000150 EHDAA2:0003150 EMAPA:32736 pre-chondrogenic condensation precartilage condensation precartilagenous condensation prechondrogenic condensation uberon UBERON:0005866 pre-cartilage condensation UBERON:0005866 A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis. uberon digit or predigit limb outgrowth UBERON:0005881 encompasses digits and prepollex. requires review autopodial extension UBERON:0005881 Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA] EMAPA:16060 FMA:9689 MA:0000005 uberon UBERON:0005906 See notes for serous membrane serous sac UBERON:0005906 Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA] FMA:69065 endoderm-derived epithelium endoepithelium uberon UBERON:0005911 endo-epithelium UBERON:0005911 Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO] AAO:0000963 EMAPA:17214 EMAPA:18043 MA:0000308 UMLS:C0222645 VSAO:0000056 XAO:0004011 uberon skeleton axiale UBERON:0005944 axial skeleton plus cranial skeleton http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton UBERON:0005944 Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. add subclasses based on resolution of CARO tracker item. Also check: adnexal gland. Note that MP implicitly includes hypodermis. the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails[MP:0010678] body hair or bristle uberon adnexae cutis skin adnexa skin adnexal structure skin appendage UBERON:0006003 integumentary adnexa UBERON:0006003 the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system The interface between the dorsal neuroepithelium and the roofplate of the fourth ventricle. The source of a number of migratory neuron populations of the hindbrain.[TAO] UBERON:0013163 DHBA:10664 EHDAA2:0000231 EMAPA:17074 TAO:0001440 XAO:0004135 ZFA:0001440 uberon cerebellar anlage cerebellar primordium cerebellum primordium dorsal part of alar plate of metencephalon future cerebellum presumptive cerebellum rostral rhombic lip UBERON:0006215 rhombic lip UBERON:0006215 The embryonic precursor of the brain. The embryonic precursor of the brain and the set of mature brain structures that derive from it (CUMBO) BAMS:Enc BTO:0004726 EFO:0003431 EHDAA:300 EHDAA:830 EMAPA:16089 EMAPA:16471 FMA:312967 RETIRED_EHDAA2:0000591 TAO:0000146 ZFA:0000146 brain rudiment presumptive brain encephalon uberon embryonic brain UBERON:0006238 future brain UBERON:0006238 A presumptive structure that has the potential to develop into a forebrain. TODO. Add relationships to neural plate (both ZFA and EMAPA time this with the neural plate) BAMS:Pros EFO:0003423 EHDAA2:0000661 EHDAA:2643 EMAPA:16640 TAO:0000062 ZFA:0000062 future prosencephalon presumptive forebrain presumptive prosencephalon uberon prosencephalon UBERON:0006240 future forebrain UBERON:0006240 EFO:0003438 EHDAA2:0000674 EHDAA:898 EMAPA:16092 EMAPA:16525 EMAPA:16755 TAO:0000417 ZFA:0000417 presumptive spinal cord presumptive spinal cord neural keel presumptive spinal cord neural plate presumptive spinal cord neural rod uberon UBERON:0006241 future spinal cord UBERON:0006241 The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] EHDAA2:0001278 EHDAA:264 EMAPA:16101 UMLS:C1518429 VHOG:0001212 uberon UBERON:0006267 notochordal plate UBERON:0006267 A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot EHDAA2:0001279 EHDAA:224 EMAPA:16102 FMA:293135 UMLS:C1518430 VHOG:0001213 uberon chordamesoderm presumptive notochord UBERON:0006268 The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process UBERON:0006268 Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. fluid FMA:280556 GAID:266 MESH:D001826 galen:BodyFluid body fluid uberon UBERON:0006314 bodily fluid UBERON:0006314 The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. currently this is an extremely generic class, encompassing both protostomes and deuterostomes. branchial pharyngeal FBbt:00005380 MAT:0000049 MIAA:0000049 uberon anterior part of foregut pharyngeal tube UBERON:0006562 pharynx UBERON:0006562 Presumptive structure of the blastula that will develop into endoderm. AAO:0000471 EFO:0003437 TAO:0000416 ZFA:0000416 uberon UBERON:0006595 presumptive endoderm UBERON:0006595 AAO:0000468 EFO:0003439 TAO:0000568 ZFA:0000568 future blood uberon UBERON:0006596 presumptive blood UBERON:0006596 Portion of embryonic tissue determined by fate mapping to become a structure. Consider merging with anlage AAO:0000479 TAO:0001116 ZFA:0001116 future structure presumptive structures uberon UBERON:0006598 presumptive structure UBERON:0006598 Presumptive structure of the blastula that will develop into ectoderm. AAO:0000470 EFO:0003466 TAO:0001376 XAO:0004132 ZFA:0001376 uberon presumptive epidermis UBERON:0006601 presumptive ectoderm UBERON:0006601 Presumptive structure of the blastula that will develop into mesoderm. AAO:0000476 EFO:0003467 TAO:0001377 ZFA:0001377 uberon UBERON:0006603 presumptive mesoderm UBERON:0006603 2 2 A joint that connects one phalanx to another along a proximodistal axis. Hinge joints between the phalanges of the hand or foot[ncithesaurus:Interphalangeal_Joint]. FMA:42765 galen:InterphalangealJoint inter-phalangeal joint inter-phalanx joint uberon UBERON:0006658 interphalangeal joint UBERON:0006658 The third segment of the limb, including either the wrist segment (carpus) or the ankle segment (tarsus) Naming conventions for pod terms under discussion within phenoscape group carpus/tarsus mesopodial limb segment mesopodial segment uberon mesopod UBERON:0006716 mesopodium region UBERON:0006716 The collection of all skeletal elements in an autopodium region. Distal section of the limb skeleton, consisting of the anterior autopodium or posterior autopodium.[VSAO] Naming conventions for pod terms under discussion within phenoscape group VSAO:0005019 autopod skeleton autopodial skeleton skeletal parts of autopod skeleton of autopod uberon autopodium UBERON:0006717 autopodial skeleton UBERON:0006717 An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium BTO:0002072 UMLS:C0221909 uberon UBERON:0006914 squamous epithelium UBERON:0006914 The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. EFO:0003709 TAO:0005077 ZFA:0005077 uberon UBERON:0006965 vascular cord UBERON:0006965 A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n AAO:0010270 BILA:0000010 CARO:0001002 EHDAA2:0003192 FMA:24137 ID:0000000 UMLS:C1515977 ZFA:0005594 uberon UBERON:0006984 Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism. anatomical surface UBERON:0006984 The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. consider FBbt:00005541 ! cardiogenic mesoderm review EHDAA2 placement AAO:0011021 BILA:0000051 EFO:0000315 EHDAA2:0000214 EHDAA:385 FMA:293143 VHOG:0001641 XAO:0000235 uberon cardiogenic mesoderm cardiogenic region heart primordia UBERON:0007005 cardiac mesoderm UBERON:0007005 Organism at the cleavage stage. BILA:0000058 uberon UBERON:0007010 cleaving embryo UBERON:0007010 The endodermal cells generate only the lining of the digestive tube and its glands; mesodermal mesenchyme cells will surround this tube to provide the muscles for peristalsis BILA:0000084 UMLS:C1514442 future digestive tract future digestive tube future gut primitive gut uberon embryonic digestive tube primordial digestive tube primordial gut UBERON:0007026 presumptive gut UBERON:0007026 A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis FBbt:00003154 SPD:0000130 TADS:0000147 dorsal tube heart uberon adult heart UBERON:0007100 Gene notes: Bmp, Nkx, Gata primary circulatory organ UBERON:0007100 An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. Kimmel et al, 1995.[TAO] EFO:0003497 TAO:0000131 ZFA:0000131 uberon presumptive central nervous system UBERON:0007135 neural keel UBERON:0007135 The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. TODO - unify naming conventions The embryonic rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. Rhombomeres Rh7-Rh4 form the myelencephalon that will give the medulla oblongata. Rhombomeres Rh3-Rh1 form the metencephalon that will form the pons and the cerebellum[NPX:PDR]. BAMS:HB CALOHA:TS-2118 EFO:0003440 EHDAA2:0001630 FMA:295640 TAO:0000569 ZFA:0000569 presumptive rhombencephalon uberon embryonic rhombencephalon future hindbrain rhombencephalon UBERON:0007277 presumptive hindbrain UBERON:0007277 Embryonic structure that gives rise to the midbrain hindbrain boundary. EFO:0003446 TAO:0001187 XAO:0004086 ZFA:0001187 presumptive MHB presumptive midbrain-hindbrain boundary uberon UBERON:0007281 presumptive midbrain hindbrain boundary UBERON:0007281 A presumptive structure that has the potential to develop into a presomitic mesoderm. EFO:0003421 TAO:0000053 ZFA:0000053 uberon presumptive segmental plates UBERON:0007282 presumptive segmental plate UBERON:0007282 A presumptive structure that has the potential to develop into a neural plate. consider merging Region of the gastrula which gives rise to the neural plate.[TAO] EFO:0003424 TAO:0000063 ZFA:0000063 prospective neuroectoderm prospective vegetal ectoderm uberon UBERON:0007284 presumptive neural plate UBERON:0007284 A presumptive structure that has the potential to develop into a paraxial mesoderm. EFO:0003443 TAO:0000591 XAO:0004134 ZFA:0000591 future paraxial mesoderm uberon UBERON:0007285 presumptive paraxial mesoderm UBERON:0007285 The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. this grouping class exists primarily to align with GO - see GO:0008544. BSA:0000073 BTO:0000313 FBbt:00004993 HAO:0000298 TADS:0000109 WBbt:0005733 epidermis epidermis (sensu Metazoa) outer epidermal layer outer epithelial layer uberon hypoderm hypodermis UBERON:0007376 outer epithelium UBERON:0007376 Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network. Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network. Le Guellec et al, 2004.[TAO] relationship loss: develops_from collagenous dermal stroma (TAO:0001186)[TAO] connective tissue in the skin is usually diffuse and irregular, although in some species collagen bundles are arranged in a distinct ordered layer in the dermis AAO:0010600 TAO:0001182 ZFA:0001182 dermal deep region uberon UBERON:0007377 stratum compactum UBERON:0007377 Outermost layer of cells surrounding the embryo. Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Sometimes used synonymously with periderm. Kimmel et al, 1995.[TAO] relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO] Originally this tissue is one cell layer thick but in most vertebrates it soon becomes a two layered structure. The outer layer gives rise to the periderm. EFO:0003425 TAO:0000086 ZFA:0000086 EVL enveloping layer uberon UBERON:0007383 enveloping layer of ectoderm UBERON:0007383 An epithelial tube open at both ends that allows fluid flow. AEO_RETIRED:0000116 RETIRED_EHDAA2:0003116 uberon UBERON:0007500 epithelial tube open at both ends UBERON:0007500 A closed epithelium with a lumen. EHDAA2:0003119 AEO:0000119 EHDAA2:0003119 uberon UBERON:0007503 epithelial vesicle UBERON:0007503 Mesenchyme with little extracellular matrix. EHDAA2:0003146 AEO:0000146 EHDAA2:0003146 uberon UBERON:0007524 dense mesenchyme tissue UBERON:0007524 Mesenchymal cells that are migrating. this class will be an important part of the NC reorganization EHDAA2:0003152 AEO:0000152 EHDAA2:0003152 uberon UBERON:0007530 migrating mesenchyme population UBERON:0007530 A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. BTO:0001338 CALOHA:TS-0998 FMA:66762 synovium stratum synoviale synovial layer synovial membrane uberon synovial tissue UBERON:0007616 layer of synovial tissue UBERON:0007616 An anatomical cavity that surrounded_by a synovial joint. FMA:11356 articular cavity (synovial joint) cavitas articularis (junctura synovialis) cavity of synovial joint uberon joint cavity synovial cavity UBERON:0007617 synovial cavity of joint UBERON:0007617 2 An anatomical structure that connects two structures junction FMA:5898 anatomical junction uberon UBERON:0007651 anatomical junction UBERON:0007651 Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. field AEO:0000170 EFO:0001649 EHDAA2:0003170 FBbt:00005426 developmental field uberon future organ organ field UBERON:0007688 anlage UBERON:0007688 Any fluid produced by a serous gland. the FMA def is Transudate contained in a serous sac FMA:20932 serous gland fluid uberon UBERON:0007794 serous fluid UBERON:0007794 Anatomical system that consists of all blood and lymph vessels. consider merging with vasculature The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system BTO:0001085 CALOHA:TS-2053 EHDAA2:0004520 EMAPA:35905 MA:0002718 UMLS:C0489903 uberon Gefaesssystem@ge UBERON:0007798 vascular system UBERON:0007798 The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. CALOHA:TS-2356 EV:0100009 FMA:280881 MA:0000006 UMLS:C0460004 WikipediaCategory:Head_and_neck galen:HeadAndNeck uberon cephalic area cephalic part of animal cephalic region head and neck head or neck UBERON:0007811 craniocervical region UBERON:0007811 An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). this encompasses non-skeletal tissue An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There are only two instances of appendage girdle regions per organism.[VSAO] UBERON:0007824 girdle girdle region FMA:24874 VSAO:0000303 uberon fin girdle fin girdle region limb girdle limb girdle region UBERON:0007823 appendage girdle region UBERON:0007823 Skeletal element that is composed of cartilage tissue and may be permanent or transient. TAO still mixes tissue and element AAO:0011130 CALOHA:TS-0118 EMAPA:32730 FMA:55107 VSAO:0000000 XAO:0004013 ZFA:0001501 cartilage organ cartilaginous element chondrogenic element uberon cartilage UBERON:0007844 cartilage element UBERON:0007844 Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue. the connective tissue hierarchy largely follows FMA with definitions from VSAO. Note that in FMA, loose-CT is irregular-CT. This means regular-CT is necessarily equivalent to dense-regular-CT (assuming a JEPD classification). FMA:20103 uberon UBERON:0007845 regular connective tissue UBERON:0007845 Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).[VSAO] Regular connective tissue, the intercellular matrix of which consists predominantly of collagen fiber bundles arranged in parallel arrays.[FMA] FMA:64781 UMLS:C0225333 VSAO:0000050 XAO:0004030 dense fibrous connective tissue dense regular collagenous connective tissue dense regular collagenous tissue regular dense connective tissue typus regularis (textus connectivus collagenosus compactus) uberon UBERON:0007846 dense regular connective tissue UBERON:0007846 An external projection of an aquatic animal as a fish used in propelling or guiding the body[BTO]. Surface structure involved in locomotion.[TAO] Surface structure involved in locomotion.[VSAO] This class groups together various structures that may have arisen through convergent evolution, including, for example, the dorsal fin of a cetacean AAO:0010374 AEO:0001004 BTO:0004649 EFO:0000875 MAT:0000087 MESH:D058500 MIAA:0000087 OpenCyc:Mx4rvVjcBZwpEbGdrcN5Y29ycA TAO:0000108 VSAO:0000099 XAO:0000002 ZFA:0000108 uberon fins UBERON:0008897 fin UBERON:0008897 EHDAA2:0004069 UMLS:C1514898 uberon UBERON:0008947 respiratory primordium UBERON:0008947 Sum total of mesenchyme in the embryo. consider adding new class (EMAPA:16097) for mesenchyme of embryo (some mesenchyme is extraembryonic - e.g. amnion mesoderm) UBERON:0003313 EHDAA2:0001113 EHDAA:177 EMAPA:16097 uberon UBERON:0009142 entire embryonic mesenchyme UBERON:0009142 A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium). Newborn and adult mice are able to regrow forelimb (finger) and hindlimb (toe) digit tips after their amputation through the distal interphalangeal joint. Regeneration of the digit tip involves the integrated regrowth of multiple tissues within 2-3 months, reaching an external morphology that is cosmetically and functionally similar to normal digits. Most importantly, regeneration of the mouse distal digit shares morphological similarities with clinical cases documenting regrowth of missing distal portions of fingers in both children and adults digit tip distal digit segment tip of digit uberon UBERON:0009551 distal segment of digit UBERON:0009551 A nail, hoof or claw. MESH:D006724 uberon hoof or claw hoof, claw or nail keratin plate keratin sheath unguis UBERON:0009564 distal limb integumentary appendage UBERON:0009564 FMA:25054 region of trunk trunk subdivision uberon UBERON:0009569 subdivision of trunk UBERON:0009569 EHDAA2:0001172 EMAPA:16977 VHOG:0000910 mantle layer lateral wall midbrain midbrain lateral wall mantle layer uberon mantle layer lateral wall mesencephalon UBERON:0009581 midbrain mantle layer UBERON:0009581 TODO - developmental relationships for lines TAO:0007044 ZFA:0007044 MHB neural plate midbrain-hindbrain boundary neural plate uberon UBERON:0009615 midbrain hindbrain boundary neural plate UBERON:0009615 A presumptive structure that has the potential to develop into a midbrain. TODO - unify naming conventions BAMS:MES EFO:0003432 EHDAA2:0000615 EMAPA:16140 EMAPA:16472 TAO:0000148 ZFA:0000148 presumptive mesencephalon uberon early midbrain future midbrain mesencephalon UBERON:0009616 presumptive midbrain UBERON:0009616 EHDAA2:0002094 trunk and cervical paraxial mesenchyme uberon trunk paraxial mesenchyme UBERON:0009618 trunk paraxial mesoderm UBERON:0009618 The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells. EMAPA mapping from TH EMAPA:32705 uberon limb mesoderm UBERON:0009749 limb mesenchyme UBERON:0009749 An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx. FMA:65024 DIJ joint DIP joint uberon UBERON:0009768 distal interphalangeal joint UBERON:0009768 The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. acinar acinus FMA:55588 uberon acini UBERON:0009842 glandular acinus UBERON:0009842 Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region considering adding 'acropodial region' Naming conventions for pod terms under discussion within phenoscape group metacarpal or metatarsal part of limb metacarpus/metatarsus region metapodial segment cannon region equine cannon region uberon metacarpus/metatarsus metapodium UBERON:0009877 metapodium region UBERON:0009877 The collection of all skeletal elements in a mesopodium. Examples: the tarsal skeleton, the carpal skeleton Limb skeleton subdivision consisting of endochondral bones increasing the freedom of movement of the autopodia, and located between zeugopodia and autopodia.[VSAO] relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO] VSAO:0005022 basipodium skeleton carpal/tarsal skeleton mesopodial skeleton mesopodium skeleton skeletal parts of mesopodium uberon basipodium mesopodium UBERON:0009878 mesopodial skeleton UBERON:0009878 EFO:0003704 TAO:0005041 ZFA:0005041 ALPM uberon UBERON:0009881 anterior lateral plate mesoderm UBERON:0009881 Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. Includes: trigeminal, otic, lateral line and epibranchial placodes. While some sensory placodes (otic and olfactory) may have homologues in basal chordates (Wada et al., 1998), the so-called neurogenenic placodes (trigeminal, otic, lateral line and epibranchial placodes) appear to have emerged at a later time (Shimeld and Holland, 2000) EFO:0003460 TAO:0001309 XAO:0004620 ZFA:0001309 neurogenic placodes uberon placodae neurogenicae UBERON:0009955 neurogenic placode UBERON:0009955 An anatomical structure that has more than one cell as a part. CARO:0010000 FBbt:00100313 multicellular structure uberon UBERON:0010000 multicellular anatomical structure UBERON:0010000 A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function. CARO:0010001 FBbt:00007229 uberon UBERON:0010001 Examples include arthropod sensilla. cell cluster organ UBERON:0010001 Mesenchyme that has the potential to develop into a dermis. check development EHDAA2:0000598 uberon UBERON:0010083 future dermis UBERON:0010083 A developing anatomical structure that has the potential to develop into a metencephalon. EHDAA2:0000623 uberon UBERON:0010092 future metencephalon UBERON:0010092 A developing anatomical structure that has the potential to develop into a myelencephalon. EHDAA2:0000640 uberon UBERON:0010096 future myelencephalon UBERON:0010096 The distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. manus, pes, paw) limb plate uberon UBERON:0010130 autopod plate UBERON:0010130 Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. DHBA:12322 EFO:0003567 EHDAA2:0004375 TAO:0000761 ZFA:0000761 basal plate midbrain basal plate midbrain region uberon UBERON:0010285 midbrain basal plate UBERON:0010285 Portion of neural tube that gives rise to the midbrain. we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed TAO:0007039 ZFA:0007039 uberon UBERON:0010286 midbrain neural tube UBERON:0010286 An anatomical structure that has some part that develops from the neural crest. Grouping term for query purposes uberon UBERON:0010314 structure with developmental contribution from neural crest UBERON:0010314 uberon UBERON:0010316 germ layer / neural crest UBERON:0010316 A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification. VSAO:0000139 XAO:0004017 ZFA:0005620 endochondral replacement element uberon UBERON:0010363 endochondral element https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern UBERON:0010363 Epithelium composed of cells that develops from the ectoderm[FMA,modified]. FMA:69064 ectoderm-derived epithelium uberon UBERON:0010371 ecto-epithelium UBERON:0010371 An appendage segment that is part of a limb/fin. limb/fin segment uberon UBERON:0010538 paired limb/fin segment UBERON:0010538 The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified]. FMA:231315 VSAO:0005028 acropodial skeleton acropodium skeleton set of phalanges skeletal parts of acropodial region uberon acropodium digital skeleton digits skeleton phalangeal skeleton skeletal parts of acropodium skeleton of digits UBERON:0010543 acropodial skeleton UBERON:0010543 Subdivision of skeleton that corresponds to metapodium region, between acropodial skeleton and mesopdoial skeleton. Endochondral bone complex located between the mesopodium and the acropodium and consisting of the metacarpals or metatarsals.[VSAO] relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: connected_to subdivision of skeleton (UBERON:0010912)[VSAO] relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO] VSAO:0005025 metacarpal/metatarsal skeleton metapodial skeleton metapodium skeleton skeletal parts of metapodium skeleton of metapodium uberon metapodium UBERON:0010546 metapodial skeleton UBERON:0010546 EMAPA:32720 uberon UBERON:0010700 phalanx pre-cartilage condensation UBERON:0010700 EMAPA:32721 uberon UBERON:0010701 phalanx cartilage element UBERON:0010701 Mesenchyme of the digit region. EMAPA:32719 uberon digital ray UBERON:0010702 digit mesenchyme UBERON:0010702 An organism subdivision that includes both an appendage and its accociated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO] Anatomical group that consists of the soft and skeletal tissues of the appendicular region of the body and the appendage proper.[VSAO] It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO] note that the FMA uses the term 'limb' to refer to the entire appendage complex (free limb plus girdle region) haendel 2012-04-23T10:46:51Z FMA:7182 VSAO:0000214 appendage complex appendage-girdle complex appendage/girdle complex girdle plus limb or fin uberon limb UBERON:0010707 appendage girdle complex UBERON:0010707 Skeletal subdivision that is a segment of the limb skeleton. note the distinction between this and skeleton of limb VSAO:0005018 uberon UBERON:0010712 limb skeleton subdivision UBERON:0010712 The collection of all skeletal elements in a single paired fin. Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO] Skeletal system that consists of the paired fins (pectoral or pelvic fins).[VSAO] TAO:0000027 VSAO:0000169 ZFA:0000027 uberon UBERON:0010713 paired fin skeleton UBERON:0010713 The subdivision of the skeleton of either the pectoral or pelvic girdle. Skeletal subdivision that is part of the appendage girdle region.[VSAO] relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: part_of subdivision of skeleton (UBERON:0010912)[VSAO] relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: proximally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO] AAO:0010686 VSAO:0000302 skeleton of girdle uberon UBERON:0010719 girdle skeleton UBERON:0010719 A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle). EMAPA:35494 MA:0000688 uberon bone of extended limb/fin region limb bone UBERON:0010740 bone of appendage girdle complex UBERON:0010740 A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg. FBbt:00007018 appendage segment appendicular segment uberon UBERON:0010758 subdivision of organism along appendicular axis UBERON:0010758 A skeletal element that is part of a limb and composed of cartilage tissue. uberon UBERON:0010881 limb cartilage element UBERON:0010881 A skeletal element that is part of a limb and composed of pre-cartilage tissue. uberon UBERON:0010882 limb bone pre-cartilage condensation UBERON:0010882 Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] FMA:23879 VSAO:0000042 skeletal subdivision uberon subdivision of skeleton (in vivo) UBERON:0010912 subdivision of skeleton UBERON:0010912 Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. FMA:7491 solid joint uberon UBERON:0011134 nonsynovial joint UBERON:0011134 Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. FMA:7483 uberon UBERON:0011137 axial skeletal system http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton UBERON:0011137 Subdivision of the skeletal system which consists of the post-cranial axial skeleton plus associated joints. axial skeletal system FMA:302077 uberon UBERON:0011138 post-cranial axial skeletal system http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton UBERON:0011138 Any synovial joint that is part of a (free) limb. FMA:258776 synovial joint of free limb segment uberon UBERON:0011139 Most limb joints are synovial, but a few such as the tibiofibular joints are syndesmoses. synovial limb joint UBERON:0011139 A multi cell part structure that is part of a central nervous system. FMA:83143 cell part cluster of neuraxis neuraxis layer uberon UBERON:0011215 central nervous system cell part cluster UBERON:0011215 A subdivision of an anatomical system. FBbt:00007330 FMA:67509 uberon UBERON:0011216 organ system subdivision UBERON:0011216 Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints. Skeletal system which consists of the appendicular skeleton plus associated joints.[VSAO] FMA:7484 VHOG:0001666 VSAO:0000306 uberon UBERON:0011249 appendicular skeletal system https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton UBERON:0011249 A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones. https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern uberon UBERON:0011250 autopod bone UBERON:0011250 compare with 'stratum basale of epidermis'. This class is the source for many adult structures - see WP2062. See also: 'enveloping layer of ectoderm' EHDAA2:0001845 uberon basal cell layer of skin outer epithelium of body UBERON:0011272 embryonic skin basal layer UBERON:0011272 The collection of all skeletal elements in an individual limb or fin. Skeletal subdivision that is part of the paired limb/fin.[VSAO] VSAO:0000301 limb/fin skeleton skeletal parts of limb/fin skeleton of limb/fin uberon UBERON:0011582 paired limb/fin skeleton UBERON:0011582 Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified]. Proximal element of the limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively.[VSAO] propodial stylopodial VSAO:0005007 stylopodium skeleton uberon mesomere 1 propodial skeleton propodium proximal metapterygial mesomere stylopod stylopodium UBERON:0011583 stylopodial skeleton UBERON:0011583 Section of the forelimb skeleton located between the stylopodium and the autopodium. zeugopodial zygopodial VSAO:0005010 epipodial skeleton skeleton of zeugopod zeugopod skeleton uberon epipodium mesomere 2 mesomere 2 skeleton zygopodium UBERON:0011584 zeugopodial skeleton UBERON:0011584 Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). consider obsoleting, coordinate with VSAO VSAO:0000006 XAO:0004021 uberon UBERON:0011585 cell condensation UBERON:0011585 A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem axial subdivision of organism uberon body segment main body segment UBERON:0011676 subdivision of organism along main body axis UBERON:0011676 A cardiovascular system that is part of a conceptus. EHDAA2:0000216 FMA:305965 conceptus cardiovascular system uberon embryonic circulatory system fetal circulatory system UBERON:0011695 embryonic cardiovascular system UBERON:0011695 A nerve that is part of a head. uberon cephalic nerve head nerve UBERON:0011779 nerve of head region UBERON:0011779 Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. FMA:20107 uberon UBERON:0011821 irregular connective tissue UBERON:0011821 Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT] FMA:20109 UMLS:C0738366 irregular dense connective tissue typus irregularis (textus connectivus collagenosus compactus) uberon UBERON:0011822 dense irregular connective tissue UBERON:0011822 Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets our OWL definition states that this is differentiated from other connective tissue types by virtue of the fact that the collage fiber component predominates, as opposed to cells and fluid. Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT] AAO:0000121 UMLS:C1511770 uberon UBERON:0011823 dense connective tissue UBERON:0011823 Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. FMA:19783 UMLS:C1253917 textus connectivus collagenosus laxus textus connectivus laxus uberon UBERON:0011825 loose connective tissue UBERON:0011825 An acinus that is part of a exocrine gland. exocrine gland acinus uberon UBERON:0011858 acinus of exocrine gland UBERON:0011858 the FMA class specifically refers to ureter FMA:63212 MESH:D024022 NIF_Subcellular:sao7547390221 uberon UBERON:0011860 collection of collagen fibrils UBERON:0011860 Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. The Epimysium also protects muscles from friction against other muscles and bones FMA:9726 UMLS:C0504096 fascia of muscle organ uberon epimysia UBERON:0011899 epimysium UBERON:0011899 The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. EHDAA2 distingsuishes between the lumen, the lining, and the 'coelomic cavity', which despire it's name, is not a space - it is the aggregate of space plus lining. coelomic EHDAA2:0004731 enterocoelom haemocoelom schizocoelom uberon coelem coelomic cavity UBERON:0011997 coelom UBERON:0011997 uberon UBERON:0012139 segment of autopod UBERON:0012139 A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region. some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod uberon acropodium (Wagner) UBERON:0012140 digitopodium region https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod UBERON:0012140 A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton. some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod uberon digitopodium skeleton of digits UBERON:0012150 skeleton of digitopodium https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod UBERON:0012150 Epithelium that derives from the mesoderm. [Automatically generated definition]. FMA:86452 mesoderm-derived epithelium mesoepithelium uberon UBERON:0012275 meso-epithelium UBERON:0012275 Skeletal subdivision consisting of all the skeletal elements in a single fin. skeleton of fin uberon UBERON:0012353 fin skeleton UBERON:0012353 The segment of the autopod that is distal to the metapodial region and consists of the digits. class refers to an entire limb segment, not just the bones acropodial limb segment acropodial region acropodial segment of autopod set of digits uberon UBERON:0012354 acropodium region UBERON:0012354 A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton. uberon digit bone UBERON:0012357 digitopodium bone UBERON:0012357 The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. FMA:86279 acinus of serous gland uberon UBERON:0013232 serous acinus UBERON:0013232 The space that surrounds an organism. external to organism outside of body uberon UBERON:0013514 space surrounding organism UBERON:0013514 uberon UBERON:0013522 subdivision of tube UBERON:0013522 2 2 An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. FMA:9338 foramen space uberon UBERON:0013686 anatomical conduit space UBERON:0013686 A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. uberon UBERON:0013701 main body axis UBERON:0013701 The region of the organism associated with the visceral organs. Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424]. AEO:0000103 BTO:0001489 EMAPA:36031 FMA:231424 uberon body whole body UBERON:0013702 body proper UBERON:0013702 Anatomical projection that is part of the integumentl system. skin projection uberon UBERON:0013703 integumentary projection UBERON:0013703 A organ component layer that is part of a integumental system. layer of skin skin layer uberon UBERON:0013754 integumentary system layer UBERON:0013754 Embryonic structure that gives rise to the telencephalon. EHDAA2:0004424 EMAPA:36024 TAO:0000571 ZFA:0000571 presumptive telencephalon uberon UBERON:0014371 paired anteriolateral division of the embryonic prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived[MP] future telencephalon UBERON:0014371 Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. EHDAA2:0002013 FMA:77169 skeleton of thorax thoracic part of axial skeleton thoracic skeleton uberon UBERON:0014477 thoracic skeleton UBERON:0014477 A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). skeletal muscle AAO:0011099 BTO:0001103 CALOHA:TS-0933 EFO:0000888 EHDAA:5035 EHDAA:5043 EHDAA:5978 EHDAA:5984 EMAPA:35988 EV:0100377 GAID:141 MA:0003148 MAT:0000302 MESH:D018482 MIAA:0000302 OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA TAO:0005277 VHOG:0000319 XAO:0000174 ZFA:0005277 uberon UBERON:0014892 skeletal muscle organ UBERON:0014892 A portion of tissue that will develop into vasculature. EFO:0003708 TAO:0005076 ZFA:0005076 uberon UBERON:0014903 primordial vasculature UBERON:0014903 A phalanx bone or its cartilage or pre-cartilage precursor. phalanx skeletal element phalanx element uberon UBERON:0015023 phalanx endochondral element UBERON:0015023 A limb bone or its cartilage or pre-cartilage precursor. limb bone skeletal element limb bone endochondral element uberon UBERON:0015061 limb endochondral element UBERON:0015061 A endochondral element that is part of a autopod region. uberon UBERON:0015063 autopod endochondral element UBERON:0015063 A autopod endochondral element that is composed primarily of a cartilage tissue. uberon UBERON:0015064 autopod cartilage UBERON:0015064 Any structure that is placed on one side of the left-right axis of a bilaterian. This class is primarily to implement taxon constraints. It may be removed in the future. uberon UBERON:0015212 lateral structure UBERON:0015212 A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. heart SPD:0000130 cardiac pump heart or heart like organ circulatory vessel uberon cardiac structure UBERON:0015228 circulatory organ UBERON:0015228 MA:0002449 heart/pericardium uberon UBERON:0015410 heart plus pericardium UBERON:0015410 A epithelium that is part of a foregut. EMAPA:32922 MA:0003204 uberon UBERON:0015833 foregut epithelium UBERON:0015833 Primordium that develops into the central nervous system UBERON:3000469 future CNS presumptive central nervous system uberon UBERON:0016879 future central nervous system UBERON:0016879 Primordium that develops into the nervous system UBERON:3000477 AAO:0000477 presumptive nervous system uberon UBERON:0016880 future nervous system UBERON:0016880 The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. AEO:0000195 EHDAA2:0000003 EMAPA:16042 extra-embryonic component extraembryonic component uberon UBERON:0016887 entire extraembryonic component UBERON:0016887 An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. AEO:0000132 uberon UBERON:0016888 transitional anatomical structure UBERON:0016888 A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. AEO:0001016 uberon UBERON:0017650 developing mesenchymal structure UBERON:0017650 Added for consistency with MA EMAPA and EHDAA2. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/104 EHDAA2:0001842 EMAPA:35578 MA:0000165 uberon UBERON:0018254 skeletal musculature UBERON:0018254 An embryonic or larval epithelium that is committed to form part of the nervous system. neurepithelium AEO:0001008 BTO:0000314 EHDAA2_RETIRED:0004654 FMA:64807 embryonic neuroepithelium neuroepithelium uberon UBERON:0034705 developing neuroepithelium UBERON:0034705 An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. AEO:0001009 uberon UBERON:0034706 proliferating neuroepithelium UBERON:0034706 A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. AEO:0001010 uberon UBERON:0034707 differentiating neuroepithelium UBERON:0034707 Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain uberon cranial nerve fiber bundle cranial nerve fiber tract cranial nerve or tract neuron projection bundle from brain UBERON:0034713 cranial neuron projection bundle UBERON:0034713 A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology. uberon UBERON:0034768 morphological feature UBERON:0034768 Any substance in the body or expelled from the body that is in a gaseous state. FMA:84580 gas in anatomical space portion of gas in anatomical space uberon UBERON:0034873 bodily gas UBERON:0034873 Any portion of gas located in a part of the respiratory system that is composed primarily of air. FMA:84581 respiratory air respiratory system air uberon UBERON:0034874 air in respiratory system UBERON:0034874 An multicellular anatomical structure that has subparts of multiple organs as a part. CARO:0020001 uberon anatomical cluster UBERON:0034921 multi organ part structure UBERON:0034921 A cluster of cells, largely surrounded by a morphological boundary. CARO:0020002 FMA:62807 uberon UBERON:0034922 cell cluster UBERON:0034922 A collection of anatomical structures that are alike in terms of their morphology or developmental origin. resolve if this should be a subclass of disconnected anatomical group. Some collections (e.g. the skeleton or skull) are arguably connected uberon UBERON:0034925 anatomical collection UBERON:0034925 A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures. uberon UBERON:0034929 external soft tissue zone UBERON:0034929 FMA:55268 organ sector organ zonal region organ zone uberon organ region with floating fiat boundary UBERON:0034944 zone of organ UBERON:0034944 Any portion of gas located in a part of the respiratory system. respiratory gas respiratory system gas uberon UBERON:0034947 gas in respiratory system UBERON:0034947 uberon duct epithelium ductal epithelium UBERON:0034969 epithelial layer of duct UBERON:0034969 The primordial mouth region of the developing head. FMA:293105 primitive mouth primordial mouth uberon UBERON:0035804 future mouth UBERON:0035804 UBERON:2007013 Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon teleost_anatomy_curators ZFA:0007013 uberon/phenoscape-anatomy preplacodal ectoderm UBERON:3000961 Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon amphibian_anatomy_curators uberon/phenoscape-anatomy external integument structure A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis. this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit. digit digit ( phalanges plus metapodial) plus soft tissue digit digitopodial subdivision digit ray uberon UBERON:5002544 digit plus metapodial segment UBERON:5002544 A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element. this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials. uberon digit digit skeleton UBERON:5102544 individual digit of digitopodial skeleton UBERON:5102544 VO:0000000 'part of organism in vaccine' is a pathogen component in vaccine that contains only a part of the pathogen organism instead of the whole organism. YH part of pathogen organism in vaccine VO:0000001 A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine. Many vaccines are developed to protect against infectious pathogens. Many vaccines are also being developed against some diseases such as cancer and autoimmune diseases. Vaccine is developed against a disease. Allergy. YH, BP, BS, MC, LC, XZ, RS a role that inheres in a prepared material entity that is designed to induce protection or treament for a diease or infection in vivo. vaccine MeSH: D014612 VO:0000002 a medical intervention that involves in adding vaccine into a host (e.g., human, mouse) in vivo with the intent to invoke an adaptive immune response. a process of administering substance in vivo that involves in adding a vaccine into a host (e.g., human) in vivo with the intent to invoke a protective or therapeutic adaptive immune response. YH, BP vaccine administration vaccination VO:0000003 YH Smallpox (Vaccinia) Vaccine, Live Trade Name: ACAM2000 ACAM2000 CVX: 75 VO:0000004 YH Product Name: Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate) Trade Name: ActHIB ActHIB CVX: 48 PMID: PMID: 1517908 PMID: 1735812 VO:0000005 YH Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed Trade Name: Adacel Adacel CVX: 115 CVX: 20 VO:0000006 YH WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf Product Name: Influenza Virus Vaccine Trade Name: Afluria Afluria CVX: 140 CVX: 141 VO:0000013 A vaccine that protects against Bacillus anthrax that causes anthrax. YH anthrax vaccine Bacillus anthracis vaccine MeSH: D022122 VO:0000014 YH Product Name: Anthrax Vaccine Adsorbed Trade Name: Biothrax Biothrax CVX: 24 VO:0000015 YH Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed Trade Name: Boostrix Boostrix CVX: 115 CVX: 20 VO:0000028 YH Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) & Hepatitis B Vaccine (Recombinant) Trade Name: Comvax Comvax CVX: 51 PMID: VO:0000029 Vaccine components see http://www.vaccinesafety.edu/components-DTaP.htm YH Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed Trade Name: DAPTACEL Daptacel CVX: 106 CVX: 20 VO:0000030 YH Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use Trade Name: DECAVAC DECAVAC CVX: 113 VO:0000031 a vaccine for active immunization to prevent invasive disease caused by Neisseria meningitidis serogroups C and Y and Haemophilus influenzae type b. MENHIBRIX is approved for use in children 6 weeks of age through 18 months of age. YH MenHibrix VO:0000033 YH Product Name: Diphtheria & Tetanus Toxoids Adsorbed Diphtheria and Tetanus Toxoids Adsorbed USP by Sanofi Pasteur Inc CVX: 28 VO:0000034 YH Product Name: Diphtheria & Tetanus Toxoids Adsorbed Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Ltd VO:0000037 A viral vaccine that protects against infection of an adenovirus. YH, SGS adenovirus vaccine VO:0000043 YH Product Name: Influenza Virus Vaccine, Trivalent, Types A and B Trade Name: FluLaval FluLaval CVX: 141 VO:0000044 YH WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf Product Name: Influenza Virus Vaccine, Live, Intranasal Trade Name: FluMist FluMist CVX: 111 VO:0000045 YH Product Name: Influenza Virus Vaccine, Trivalent, Types A and B Trade Name: Fluarix Fluarix CVX: 140 VO:0000046 YH Product Name: Influenza Virus Vaccine, Trivalent, Types A and B Trade Name: Fluvirin Fluvirin CVX: 140 CVX: 141 VO:0000047 YH Product Name: Influenza Virus Vaccine, Trivalent, Types A and B Trade Name: Fluzone Fluzone CVX: 140 CVX: 141 CVX: 144 VO:0000049 YH Product Name: Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine Trade Name: Gardasil Gardasil CVX: 62 VO:0000052 YH Product Name: Hepatitis A Vaccine, Inactivated Trade Name: Havrix Havrix CVX: 52 CVX: 83 VO:0000053 A bacterial vaccine that prevents Neisseria meningitidis infection. YH Meningococcal vaccine Neisseria meningitidis vaccine MeSH: D022401 VO:0000054 YH Product Name: Poliovirus Vaccine Inactivated (Monkey Kidney Cell) Trade Name: IPOL IPOL CVX: 10 PMID: VO:0000063 YH Product Name: Rabies Vaccine Trade Name: Imovax Imovax Rabies (USA) CVX: 18 VO:0000064 YH Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed Trade Name: Infanrix Infanrix CVX: 20 VO:0000065 YH WEB: http://atomicnewsreview.org/2009/10/22/approval-for-the-arepanrix%E2%84%A2-gsk-vaccine-in-canada/ Product Name: Influenza Virus Vaccine, H5N1 (for National Stockpile) Influenza Virus Vaccine H5N1 (Sanofi Pasteur Inc) VO:0000066 YH Product Name: Japanese Encephalitis Virus Vaccine Inactivated Trade Name: JE-Vax JE-Vax CVX: 39 VO:0000067 YH Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine Trade Name: KINRIX Kinrix CVX: 130 VO:0000071 YH Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine WEB: http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm176044.htm Product Name: Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine Trade Name: Menactra Menactra CVX: 114 VO:0000073 YH Product Name: Rubella Virus Vaccine Live Trade Name: Meruvax II Meruvax II CVX: 06 VO:0000079 an influenza vaccine that is similar to Fluzone but has high dose. YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305079.pdf Product Name: Influenza Virus Vaccine, Trivalent, Types A and B Trade Name: Fluzone Fluzone High-dose CVX: 140 CVX: 141 CVX: 144 VO:0000082 YH Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Hepatitis B (recombinant) and Inactivated Poliovirus Vaccine Combined Trade Name: Pediarix Pediarix CVX: 110 VO:0000083 YH Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) Trade Name: PedvaxHIB PedvaxHIB CVX: 49 PMID: PMID: 2791073 VO:0000084 YH Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine Trade Name: Pentacel Pentacel CVX: 120 VO:0000088 YH Product Name: Pneumococcal Vaccine, Polyvalent Trade Name: Pneumovax 23 Pneumovax 23 (USA) CVX: 33 VO:0000090 YH Product Name: Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) Trade Name: Prevnar Prevnar (USA) CVX: 100 VO:0000091 A Measles-Mumps-Rubella-Vericella vaccine that is live and manufactured by Merck & Co, Inc. YH WEB: http://www.merck.com/product/usa/pi_circulars/p/proquad/proquad_pi.pdf Product Name: Measles, Mumps, Rubella and Varicella Virus Vaccine Live Trade Name: ProQuad ProQuad CVX: 94 VO:0000092 YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM305080.pdf Trade Name: Fluzone intradermal Fluzone intradermal VO:0000093 a vaccine adjuvant that is formed as a mineral salt. SGS, YH mineral salt vaccine adjuvant CVX: 119 VO:0000094 YH WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf Product Name: Rabies Vaccine Trade Name: RabAvert RabAvert CVX: 18 VO:0000096 YH, SGS Adenovirus Type 4 and Type 7 Vaccine, Live, Oral CVX: 143; UMLS_CUI: C0695130; SNOMEDCT: 442561000 VO:0000097 YH Product Name: Rotavirus Vaccine, Live, Oral, Pentavalent Trade Name: RotaTeq RotaTeq CVX: 116 VO:0000102 YH Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use Trade Name: TENIVAC TENIVAC VO:0000104 YH Product Name: Typhoid Vi Polysaccharide Vaccine Trade Name: TYPHIM Vi TYPHIM Vi CVX: 101 VO:0000111 YH Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use Tetanus and Diphtheria Toxoids Adsorbed by MA Biologic Lab VO:0000112 YH Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed Trade Name: Tripedia Tripedia CVX: 20 VO:0000113 YH Product Name: Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine Trade Name: Twinrix Twinrix CVX: 104 VO:0000119 YH Product Name: Varicella Virus Vaccine Live Trade Name: Varivax Varivax CVX: 21 VO:0000120 YH Product Name: Typhoid Vaccine Live Oral Ty21a Trade Name: Vivotif Vivotif (USA) CVX: 25 VO:0000121 YH http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf Product Name: Yellow Fever Vaccine Trade Name: YF-Vax YF-Vax CVX: 37 VO:0000123 A viral vaccine that protects against infection with Yellow fever virus. YH Yellow fever virus vaccine MeSH: D022341 VO:0000124 YH Product Name: Zoster Vaccine, Live, (Oka/Merck) Trade Name: Zostavax Zostavax CVX: 121 VO:0000147 an adjuvant role that inheres in a vaccine component which is added as part of a vaccine and induces enhanced adaptive immune response to the vaccine antigen. YH vaccine adjuvant role VO:0000165 A vaccine that targets against a bacterial disease. YH bacterial vaccine MeSH: D001428 VO:0000173 a virulence of vaccine organism that shows an attenuated pheontype of the organism as the major component of a vaccine. YH vaccine organism live attenuated VO:0000179 a processed material that is output of the vaccine preparation and part of a vaccine. YH cardinal part of vaccine vaccine ingredient vaccine component VO:0000194 a USA licensed vaccine role that inheres ina vaccine approven to be by the US FDA to be used for humans in the USA. YH USA licensed human vaccine role VO:0000207 A vaccine contraindication is a contraindication that increases the risks of a vaccination. YH contraindication for vaccination vaccine contraindication VO:0000211 an organismal quality of a whole organism vaccine where the whole organism is inactivated/killed and lacks the capability of replication. YH vaccine organism killed vaccine organism inactivated VO:0000213 YH hypersensitivity to chicken product VO:0000218 YH hypersensitivity to chicken egg VO:0000251 A DNA vaccine plasmid vector that has the plasmid label pgp.LAMP-1. This plasmid has a CMV promoter and contains the human lysosomal-associated membrane protein-1 signal sequence. Rebecca Racz, Yongqun He pgp.LAMP-1 DNA vaccine plasmid PMID: 19356616 VO:0000278 vaccine function is a function that inheres in a vaccine that induces protective immune response against a disease. It is realized in the immunization process in the host. PERSPN: Oliver He: There has been hot discussion about whether we use 'vaccine function' or 'vaccine role'. Vaccine role may not be the good term to use. Vaccine is designed to be 'vaccine', so it should be vaccine function. One special case is cowpox virus. The cowpox virus can be mixed with some liquid like water and used as a smallpox vaccine. In this case, people often say: the cowpox virus has a 'vaccine role'. However, the cowpox virus vaccine is a processed material of a mix of the virus with water. The virus is a virus, it is not a vaccine per se. Therefore, vaccine role may not be an accurate term. YH, MC, XZ, and AR vaccine function VO:0000299 YH company VO:0000300 a medical intervention site that is used for injection of a substance. YH, SS, ZX injection site VO:0000340 a route of administration that inject the material(such as vaccines, allergens) directly into a muscle. YH,YL intramuscular injection route I.M. intramuscular route VO:0000341 rounte of administration that located in nose. YH I.N. intranasal route VO:0000343 YH intranasal route by spray VO:0000415 YL,YH Page 73, Chapter 6, Vaccine, 5th Edition. EXPERT CONSULT by Plotkin SA., et. al. 2008 a role inheres in a material entity, that has been added into a vaccine's formulation by the manufacture for a specific purpose. For example: adjuvant to enhance the effect of immunogen, perservatives, stablizers and those materials added for affecting PH and isotonicity. vaccine additive role VO:0000419 a Varicella-zoster virus vaccine that is live attenuated. YH Varicella-zoster virus live vaccine SNOMEDCT: 412530002; ULMS_CUI: C0770687 VO:0000420 a vaccine component that originates from an organism such as a pathogen or a modified organism. YH pathogen organism component in vaccine VO:0000424 a pneumococcal vaccine that is formed using polyvalent polysaccharides YH WEB: http://www.who.int/vaccines/en/pneumococcus.shtml The most common form of the polyvalent pneumococcal vaccine is called the protein-polysaccharide combinations which is known as conjugate vaccines and contain 7–11 selected polysaccharides bound to a protein carrier. The protein-polysaccharide combinations are able to induce a T-cell dependent immune response. These vaccines are likely to be protective even in children under two years of age, and may reduce pneumococcal transmission through a herd effect. polyvalent pneumococcal vaccine VO:0000433 YH WEB: http://en.wikipedia.org/wiki/Vaccinia a Smallpox virus vaccine that uses vaccinia virus Vaccinia virus is well known for its role as a vaccine that helped eradicate the smallpox disease, making it the first human disease to be successfully eradicated by science. vaccinia virus vaccine VO:0000435 a vaccine component that is composed of a plasmid and used in the generation of a DNA vaccine. YH DNA vaccine plasmid vector VO:0000452 preventive vaccine function is a vaccine function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which protects against a specific disorder. YH prophylactic vaccine function preventive vaccine function VO:0000464 YH protein of pathogen organism as vaccine component VO:0000486 YH a chicken egg protein allergen where the protein allergen is ovalbumin, the main protein found in egg write, making up 60-65% of the total protein. WEB: http://en.wikipedia.org/wiki/Ovalbumin chicken ovalbumin egg protein allergen VO:0000489 a licensed vaccine role that is bears in a licensed human vaccine. YH licensed human vaccine role VO:0000490 immunization is a processual entity that primes or modifies an adaptivie immune response to some antigens. YH, XZ, BP WEB: http://en.wikipedia.org/wiki/Immunization immunization VO:0000491 Active immunization is an immunization process that entails the introduction of a foreign molecule into the body, which causes the body itself to generate adaptive immunity against the target. YH, XZ WEB: http://en.wikipedia.org/wiki/Immunization active immunization VO:0000494 artificial active immunization is an active immunization that occurs when a person or animal is vaccinated with a specific vaccine. YH, XZ artificial active immunization WEB: http://en.wikipedia.org/wiki/Immunization vaccine immunization VO:0000495 induction of adaptive immune response to antigen is an active immunization process that results in induction of adaptive immune response to some antigens, for example, in a vaccine. YH, XZ induction of adaptive immune response to antigen VO:0000496 disorder prevention is a processual entity that prevents a disorder that is the physical basis of a disease. YH, XZ disorder prevention VO:0000497 disorder treatment is a processual entity that leads to treat a disorder that is the physical basis of a disease. YH, XZ disorder treatment VO:0000498 modification of adaptive immune response to antigen is an active immunization process that results in modification of an adaptive immune response to some antigens, for example, in a therapeutic vaccine. YH, XZ modification of adaptive immune response to antigen VO:0000512 a viral vaccine against a disease caused by a virus belong to Poxviridae. Pox vaccine VO:0000532 a route of administration that is loacted in the hypodermis (subcutaneous tissue) region. YL YH S.C. subcutaneous route VO:0000544 a vaccinee that is a human being human vaccinee VO:0000545 a population of human beings who are vaccinated. human vaccinee population VO:0000562 The therapeutic vaccine function is a function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which ameliorates a specific disorder. YH therapeutic vaccine function VO:0000574 a path that is located in gross anatomical part of an organism (e.g., human) and is used for administering a vaccine, a drug, fluid, poison, or other substance into the body. CDISC has a codelist: Rout of Administration. Desription from CDISC: The course by which a substance was administered in order to reach the site of action in the body. CDISC_SDTM_Route_of_Administration_Terminology YH,YL http://en.wikipedia.org/wiki/Route_of_administration route of administration http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38114 http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66729 VO:0000580 a vaccine component that is chemical substance added to vaccine and enhance and direct immune response to protective antigen. Many of vaccine adjuvants cause a range of serious side-effects. YH vaccine adjuvant VO:0000585 immunization objective is the specification of an objective to achieve immunization. YH, XZ WEB: http://en.wikipedia.org/wiki/Immunization immunization objective VO:0000590 vaccine preparation is a manufacturing process to produce a vaccine. YH, BP vaccine generation vaccine production vaccine preparation VO:0000605 a Canada licensed vaccine role that indicates the vaccine is used for human YH Canada licensed human vaccine role VO:0000609 A vaccine that targets against a viral disease. YH viral vaccine MeSH: D014765 VO:0000615 YH a role that inheres in a prepared material entity that is designed to induce protection or treatment for a disease or infection. vaccine role VO:0000617 YH a role that inheres in a material entity that becomes an ingredient of a vaccine. vaccine component role VO:0000625 a vaccine role that indicates the vaccine being a conjugate vaccine. YH conjugate vaccine role VO:0000630 licensed vaccine role is a regulation-assigned role that indicates that a vaccine obtains official approval for commercial production and selling on the market. YH licensed vaccine role VO:0000639 A bacterial vaccine that protects against infection with Clostridium spp. YH Clostridium vaccine VO:0000640 a Clostridium vaccine that protects against infection with Clostridium tetani that causes tenanus. YH tetanus vaccine Clostridium tetani vaccine VO:0000642 A viral vaccine that protects against infection with influenza virus. YH Influenza vaccine Influenza virus vaccine MeSH: D007252; UMLS_CUI: C0021403; SNOMEDCT: 46233009 VO:0000644 A viral vaccine that protects against infection with Hepatitis B virus. YH Hepatitis B virus vaccine MeSH: D017325 VO:0000646 A viral vaccine that protects against infection with Hepatitis A virus. YH Hepatitis A virus vaccine MeSH: D022362 VO:0000650 A viral vaccine that protects against infection with Rabies virus. YH Rabies virus vaccine MeSH: D011819; SNOMEDCT: 333606008; UMLS_CUI:C0034496 VO:0000651 A viral vaccine that protects against infection with Smallpox virus. YH Smallpox virus vaccine MeSH: D012900 VO:0000654 A viral vaccine that protects against infection with Measles virus. YH Measles vaccine Measles virus vaccine MeSH: D008458 VO:0000658 A viral vaccine that protects against infection with Rotavirus. YH Rotavirus vaccine MeSH: D022243; UMLS_CUI: C0597418; SNOMEDCT: 116077000 VO:0000661 A bacterial vaccine that protects against infection with Haemophilus. YH Haemophilus vaccine MeSH: D018073 VO:0000662 YH Haemophilus b vaccine Haemophilus influenzae serotype b vaccine VO:0000664 A viral vaccine that protects against infection with Poliovirus. YH Poliovirus vaccine MeSH: D023321 VO:0000665 A viral vaccine that protects against infection with Japanese encephalitis virus. YH Japanese encephalitis vaccine Japanese encephalitis virus vaccine MeSH: D022321 VO:0000667 a vaccine against human papillomavirus infection YH human papillomavirus vaccine UMLS_CUI: C1512511; SNOMEDCT: 424519000 VO:0000669 a Herpesvirus vaccine that is used against Varicella-zoster virus infection. YH chickenpox virus vaccine Varicella-zoster virus vaccine UMLS_CUI: C0078048; SNOMEDCT: 108729007 VO:0000671 a Salmonella vaccine against typhoid fever (or called typoid), caused by Salmonella enterica enterica, serovar Typhi. YH typhoid vaccine Salmonella typhi vaccine VO:0000675 a Streptococcal vaccine that is used against S. pneumoniae infection, which causes pneumococcal diseases. YH pneumococcal vaccine WEB: http://www.who.int/vaccines/en/pneumococcus.shtml Streptococcus pneumoniae vaccine VO:0000713 YH vaccine allergen disposition VO:0000727 A viral vaccine that protects against infection with Herpesvirus. YH Herpesvirus vaccine MeSH: D022283 VO:0000731 A Measles-Mumps vaccine that also protects against infection with Rubella virus. YH MMR MMR is usually live attenuated. Measles-Mumps-Rubella vaccine VO:0000732 A Corynebacterium diphtheriae vaccine that also protect against infection with Clostridium tetani. YH Diphtheria-Tetanus vaccine VO:0000735 A bacterial vaccine that protects against infection with Corynebacterium diphtheriae that causes Diphtheria. YH diphtheria vaccine Corynebacterium diphtheriae vaccine VO:0000736 A Measles virus vaccine that also protects against infection with Mumps virus. YH Measles-Mumps vaccine VO:0000737 A Measles-Mumps-Rubella vaccine that also protects against Vericella. YH Measles-Mumps-Rubella-Vericella vaccine VO:0000738 YH DTP vaccine DTaP vaccine Diphtheria-Tetanus-Pertussis vaccine UMLS_CUI: C0012559; SNOMEDCT: 421245007 VO:0000741 YH Haemophilus influenzae serotype b VO:0000742 YH Diphtheria-Tetanus-Pertussis-Poliovirus vaccine VO:0000743 YH Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine VO:0000744 YH Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine VO:0000745 YH Hepatitis A&B vaccine VO:0000746 a viral vaccine against Hepatitis B virus and at the same time against bacterial H. influenzae serotype b. YH Haemophilus b and Hepatitis B vaccine VO:0000748 A viral vaccine that protects against infection with Papillomavirus. YH Papillomavirus vaccine MeSH: D053918 VO:0000768 A bacterial vaccine that protects against infections by various Salmonella species. YH Salmonella vaccine MeSH: D022562 VO:0000772 A bacterial vaccine that prevents streptococcal infections. YH Streptococcus vaccine Streptococcal vaccine MeSH: D022541 VO:0000812 a licensed vaccine role that indicates the vaccine occurs in USA. YH USA licensed vaccine role VO:0000851 YH antimicrobial agent in vaccine vaccine preservative VO:0000853 a vaccine additive that helps to protect the vaccine from adverse conditions such as the freeze-drying process (for those vaccines that are freeze-dried) or heat. YH Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 75. vaccine stabilizer VO:0000854 a vaccine component that remains from the vaccine manufacturing process. Although no all manufacturing residuals may be identified and quantified, their presence and quantity is assumed to be constant because of the constancy of the manufacturing process. YH Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. vaccine residual VO:0000856 a vaccine residual that is generatead from cell culture for vaccine preparation. Examples include: antibiotics, sensitizing substances, bacterial and cellular residuals, and adventitious agents. YH Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78-81. cell culture residual in vaccine VO:0000864 a licensed status that occurs in Canada. YH Canada licensed vaccine role VO:0000884 a mineral salt vaccine adjuvant that is composed of aluminum salt. Aluminum vaccine adjuvant is a vaccine adjuvant that is composed of some aluminum compound. YH aluminum vaccine adjuvant VO:0000885 a role inhers in a vaccine component that when added into a vccine formmulation, it can prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during administrating process or the manufacturing process. YH,YL P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al. The CFR requires that, with certain defined exceptions, preservatives must be added to mulitdose vials of vaccine. (P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al.) vaccine preservative role VO:0000886 YH a route of administration that located in the mouth oral route VO:0000887 a route of administration that inject the material(such as vaccines, allergens) into the skin itself. YH,YL intradermal injection route I.D. intradermal route VO:0000888 YH phenol vaccine preservative VO:0000897 Age at vaccination is the age of an experiment animal at the time of vaccination. YH age at vaccination VO:0000910 vaccine allergen is a material entity that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals who has been vaccinated with a vaccine. YH, ZX WEB: http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf vaccine allergen VO:0000912 YH, ZX, MC chicken egg protein allergen is a vaccine allergen that is composed of chicken egg protein. chicken egg protein allergen VO:0000913 YH, ZX latex vaccine allergen VO:0000920 a cell culture residual in vaccine that is bovine albumin. YH, ZX bovine albumin cell culture residual in vaccine VO:0000931 a cell culture residual in vaccine that is residual protein from cell culture. YH vaccine residual protein from cell culture VO:0000934 a vaccine stabilizer that is specifically made by sorbitol. YH, YL glucitol Sorbitol, also known as glucitol, is a sugar alcohol that the human body metabolizes slowly. It can be obtained by reduction of glucose, changing the aldehyde group to a hydroxyl group. Sorbitol is found in apples, pears, peaches, and prunes. It is synthesized by sorbitol-6-phosphate dehydrogenase, and converted to fructose by succinate dehydrogenase and sorbitol dehydrogenase. Succinate dehydrogenase is an enzyme complex that participates in the citric acid cycle. (wikipedia) sorbitol vaccine stabilizer VO:0000938 YL PMID: 19608270 xanthan gum vaccine ajuvant VO:0000940 a cell culture residual in vaccine that is yeast protein. YH yeast protein cell culture residual in vaccine VO:0000943 Diphtheria-Tetanus-Poliovirus vaccine VO:0000968 A DNA vaccine plasmid vector that has the plasmid label pBLUESCRIPT. Rebecca Racz, Yongqun He Davidson College - pBLUESCRIPT: Plasmids and Phages Combine For pBluescript [http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/Keogh/plasmids.html] Derived from pUC vectors; cross between phages and plasmids and therefore in a special category called "phagemids" (Davidson College - pBLUESCRIPT) The plasmid length is: 2961 pBLUESCRIPT DNA vaccine plasmid DNAVaxDB Plasmid ID: 180 VO:0000969 A DNA vaccine plasmid vector that has the plasmid label nkCMVint. Rebecca Racz, Yongqun He A pUC-18-based plasmid; also contains intron A and an SV40 polyadenylation termination signal sequence. It has a CMV promoter. nkCMVint DNA vaccine plasmid DNAVaxDB Plasmid ID: 181 PMID: 9234529 VO:0000978 Yongqun He Trade Name: Flublok Flublok VO:0000980 Yongqun He Trade Name: Flucelvax Flucelvax VO:0000982 YH FluMist Quadrivalent VO:0000983 YH Fluarix Quadrivalent VO:0000984 a tetanus vaccine manusfactured by Sanofi Pasteur Inc. that is only for booster use (not recommended for primary immunization) YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142732.pdf Tetanus Toxoid (for Boost use Only) by Sanofi Pasteur Inc VO:0001015 a live attenuated quality of a virus vaccine strain. YH viral vaccine organism live attenuated VO:0001126 YH Agriflu CVX: 140 VO:0001139 vaccine viability is a viability of a vaccine organism. YH, ZX vaccine organism viability VO:0001187 a vaccination that occurs in the intramuscular route. YH, YL intramuscular vaccination VO:0001244 ZX Prevnar 13 CVX: 133 VIOLIN Vaccine ID: 1114 VO:0001246 Menveo CVX: 136 VIOLIN Vaccine ID: 1113 VO:0001254 YH capsular polysaccharide of pathogen organism as vaccine component VO:0001256 YH polysaccharide of pathogen organism as vaccine component VO:0001274 a role of host that contains vaccine. It is a role that inheres in an organism that is the target of a vaccine administration (vaccination process). YH, ZX vaccine host role VO:0001357 A vaccine aduvant that contains synthetic material. YH, SGS synthetic vaccine adjuvant VO:0001374 an organism that is vaccinated with a vaccine vaccinated organism YH, YL, MC vaccinee VO:0001479 The objective that intends to produce vaccine via the vaccine preparation process. YH vaccine target specification VO:0003019 YL vaccination process that occurs in intradermal route. intradermal vaccination VO:0003021 vaccination process that occurs in oral route. YL oral vaccination VO:0003022 vaccination process that occurs in the subcutaneous route YL subcutaneous vaccination VO:0003026 a role inheres in vaccine component when added into vaccine's formulation, it tends to inhibit the reaction between two or more other vaccine substances in the final vaccine formulation; it also helps to protect the vaccine from adverse conditions such as the freeze-drying process or heat. YL vaccine stabilizer role VO:0003034 a vaccine stabilizer that is specifically made by a sugar. YH, YL sugar vaccine stabilizer VO:0003049 The conjugate protein is a part of a conjugate vaccine and acts as a carrier protein that is covalently attached to a vaccine antigen with poor antigenicity (e.g., a polysaccharide). A conjugate protein is able to induce T-cell-dependent immune responses and stimulate the production of immune memory. YL,YH vaccine conjugate protein VO:0003050 role inheres in a material eneitity that union itself chemically with a relative weak vaccine antigen to form a new whole that can create an effective miinuogen. The YL vaccine conjugate role VO:0003051 YL epicutaneous (application onto the skin), e percutaneous route VO:0003052 Administration of a drug by the way of absorption through the skin, usually for systemic action. The route allows sustained therapeutic plasma drug levels and avoids first pass effect. Simplicity of administration tends to result in high patient compliance. YL percutaneous vaccination VO:0010637 A viral vaccine that protects against infection with Rubella virus. YH Rubella virus vaccine MeSH: D012411 VO:0010711 YH, ZX Product Name: Hepatitis B Vaccine (Recombinant) Trade Name: Engerix-B Engerix-B CVX: 08 CVX: 44 VO:0010715 YH, ZX Trade Name: Hiberix Hiberix CVX: 48 VO:0010727 YH, ZX todo: Polysaccharide Trade Name: Menomune A/C/Y/W-135 Menomune A/C/Y/W-135 VO:0010737 YH, ZX todo: Recombinant protein Trade Name: Recombivax HB Recombivax HB CVX: 08 CVX: 43 CVX: 44 VO:0010738 YH, ZX ROTARIX todo: Live virus Trade Name: Rotarix Rotarix VO:0010745 YH, ZX VAQTA todo: Killed virus Trade Name: Vaqta Vaqta VO:0011558 YH, ZX Ixiaro CVX: 134 VIOLIN Vaccine ID: 741 VO:0011559 YH, ZX Cervarix CVX: 118 VIOLIN Vaccine ID: 740 VO:0012185 A vaccine that protects against Haemophilus influenzae. YH, ZX Haemophilus influenzae Haemophilus influenzae vaccine chemosensory sensory organ nose olfactory system 1a: The part of the face that bears the nostrils and covers the anterior part of the nasal cavity; broadly: this part together with the nasal cavity.n1b: The anterior part of the head at the top or end of the muzzle: snout, proboscis.n2: The vertebrate olfactory organ.[accessedResource: BTO:0000840][accessDate: 05-04-2011] Any sense organ (FBbt:00005155) that functions in (some) detection of chemical stimulus involved in sensory perception (GO:0050907).[accessedResource: FBbt:00005157][accessDate: 05-04-2011] Nose[accessedResource: FMAID:46472][accessDate: 05-04-2011] chemosensory sensory organ[accessedResource: FBbt:00005157][accessDate: 05-04-2011] olfactory system[accessedResource: TAO:0001149][accessDate: 05-04-2011] *Subdivision of face which consists of the nasal skeleton, nasal septum and nasal cavity. 1a: The part of the face that bears the nostrils and covers the anterior part of the nasal cavity; broadly: this part together with the nasal cavity.n1b: The anterior part of the head at the top or end of the muzzle: snout, proboscis.n2: The vertebrate olfactory organ. 1a: The part of the face that bears the nostrils and covers the anterior part of the nasal cavity; broadly: this part together with the nasal cavity.nb: The anterior part of the head at the top or end of the muzzle: snout, proboscis.n2. The vertebrate olfactory organ. Any sense organ (FBbt:00005155) that functions in (some) detection of chemical stimulus involved in sensory perception (GO:0050907). Any sense organ (FBbt:00005155) that has function 'detection of chemical stimulus involved in sensory perception (GO:0050907)'. AAO:0000334 BTO:0000840 EHDAA:1502 EMAPA:16542 EV:0100037 FBbt:00005157 FMAID:46472 MA:0000281 MFO:0003640 SAEL:72 TAO:0001149 XAO:0000201 XAO:0003033 ZFA:0001149 James Malone nose structure owl:Nothing ready for release pending final vetting axiom holds for all times Intercell Biomedical YH http://www.acambis.com/ Acambis, Inc YH http://www.crucell.com/ Berna Biotech, Ltd YH http://www.bioport.com/ BioPort Corp YH http://www.csl.com.au/ CSL Limited YH http://www.gsk-bio.com/english/index.html GlaxoSmithKline Biologicals YH http://www.ctidirectory.com/search/company.cfm?company=129584 ID Biomedical Corp of Quebec YH Massachusetts Public Health Biologic Lab YH http://www.medimmune.com/ MedImmune Vaccines, Inc YH Merck Sharp & Dohme Corp. http://www.merck.com/ Merck & Co, Inc YH http://www.novartis.com/about-novartis/our-businesses/vaccines-diagnostic.shtml Novartis Vaccines and Diagnostics YH http://read.jst.go.jp/public/cs_kkn_004EventAction.do?action5=event&lang_act5=E&kcd1_act5=9535000000&judge_act5=2 Research Foundation for Microbial Diseases of Osaka University YH http://www.sanofipasteur.com Sanofi Pasteur Limited YH Aventis Pasteur Inc. http://www.sanofipasteur.us Sanofi Pasteur, Inc YH http://www.wyeth.com/ Wyeth Pharmaceuticals Inc YH http://www.sanofipasteur.co.za/ Sanofi Pasteur, SA YH, ZX http://www.merckfrosst.ca/ Merck Frosst YH Aqua Health http://www.novartis.com/ Novartis Vical, Inc. http://www.vical.com/ Vision Release: 1.0.34 has part my body has part my brain (continuant parthood, two material entities) my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) this year has part this day (occurrent parthood) a core relation that holds between a whole and its part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime has_part BFO:0000051 uberon has_part has_part has part has part realized in this disease is realized in this disease course this fragility is realized in this shattering this investigator role is realized in this investigation is realized by realized_in [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realized in concretized-by_st [copied from inverse property 'concretizes at some time'] You may concretize a piece of software by installing it in your computer [copied from inverse property 'concretizes at some time'] You may concretize a recipe that you find in a cookbook by turning it into a plan which exists as a realizable dependent continuant in your head. [copied from inverse property 'concretizes at some time'] you may concretize a poem as a pattern of memory traces in your head [copied from inverse property 'concretizes at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'concretizes at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'concretizes@en'(x,y,t) [copied from inverse property 'concretizes at some time'] b concretizes c at t means: b is a specifically dependent continuant & c is a generically dependent continuant & for some independent continuant that is not a spatial region d, b s-depends_on d at t & c g-depends on d at t & if c migrates from bearer d to another bearer e than a copy of b will be created in e. (axiom label in BFO2 Reference: [075-002]) concretized by at some time preceded by X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X) x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 is preceded by takes place after uberon preceded_by preceded_by preceded by preceded_by precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. BFO:0000063 uberon precedes precedes precedes precedes occurs-in occursIn occurs in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t [XXX-001 occurs_in unfolds in unfolds_in Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant occurs in located-at-r_st occupiesSpatialRegionAt Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'occupies spatial region at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'occupies spatial region@en'(x,y,t) BFO2 Reference: independent continuant BFO2 Reference: spatial region b occupies_spatial_region r at t means that r is a spatial region in which independent continuant b is exactly located (axiom label in BFO2 Reference: [041-002]) every region r is occupies_spatial_region r at all times. (axiom label in BFO2 Reference: [042-002]) if b occupies_spatial_region r at t & b continuant_part_of b at t, then there is some r which is continuant_part_of r at t such that b occupies_spatial_region r at t. (axiom label in BFO2 Reference: [043-001]) (forall (r t) (if (Region r) (occupiesSpatialRegionAt r r t))) // axiom label in BFO2 CLIF: [042-002] (forall (x r t) (if (occupiesSpatialRegionAt x r t) (and (SpatialRegion r) (IndependentContinuant x)))) // axiom label in BFO2 CLIF: [041-002] (forall (x y r_1 t) (if (and (occupiesSpatialRegionAt x r_1 t) (continuantPartOfAt y x t)) (exists (r_2) (and (continuantPartOfAt r_2 r_1 t) (occupiesSpatialRegionAt y r_2 t))))) // axiom label in BFO2 CLIF: [043-001] occupies spatial region at some time exists-at existsAt BFO2 Reference: entity BFO2 Reference: temporal region b exists_at t means: b is an entity which exists at some temporal region t. (axiom label in BFO2 Reference: [118-002]) exists at st-projects-onto-s_st projects onto spatial region at some time st-projects-onto-t projects onto temporal region s-depends-on_st specificallyDependsOn A pain s-depends_on the organism that is experiencing the pain a gait s-depends_on the walking object. (All at some specific time.) a shape s-depends_on the shaped object one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs reciprocal s-dependence between occurrents: a process of buying and the associated process of selling reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball the one-sided dependence of an occurrent on an independent continuant: handwave on a hand the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45 the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45 the two-sided reciprocal s-dependence of the roles of husband and wife [20 Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'specifically depends on at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'specifically depends on@en'(x,y,t) BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28 BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20 BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place. BFO2 Reference: specifically dependent continuant\; process; process boundary To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64 If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001]) If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001]) If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002]) an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002]) if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002]) (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002] (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002] (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001] (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002] (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001] specifically depends on at some time x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer cjm 2009-07-31T02:15:46Z BSPO:0000096 uberon anterior_to anterior_to anterior_to x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal). BSPO:0000097 uberon distal_to distal_to distal_to x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000098 uberon dorsal_to dorsal_to dorsal_to x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. BSPO:0000099 caudal_to uberon posterior_to posterior_to posterior_to x proximal_to y iff x is closer to the point of attachment with the body than y. BSPO:0000100 uberon proximal_to proximal_to proximal_to x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). BSPO:0000102 uberon ventral_to ventral_to ventral_to Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. BSPO:0000107 uberon deep_to deep_to deep_to Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. BSPO:0000108 uberon superficial_to superficial_to superficial_to X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion. BSPO:0000120 uberon in_left_side_of in_left_side_of in_left_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion. BSPO:0000121 uberon in_right_side_of in_right_side_of in_right_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. BSPO:0000123 uberon in_anterior_side_of in_anterior_side_of in_anterior_side_of X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure BSPO:0000126 uberon in_lateral_side_of in_lateral_side_of in_lateral_side_of https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y BSPO:0001106 uberon proximalmost_part_of proximalmost_part_of proximalmost_part_of An electrocardiogram qt prolonged AE is_evidence_of arrhythmia AE; arrhythmia AE is_evidence_of cardiomyopathy AE; fever AE is_evidence_of inflammation AE; fever AE is_evidence_of viral infection AE; plural effusion AE is_evidence_of cardiac disorder AE. This represents a relation between two adverse events AE1 and AE2. However, AE1 may be an evidence of another adverse event AE3, and a dfferent adverse event AE4 may also be an evidence of the same AE2. SS, YH, YL is evidence of An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased. an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality. Yongqun He has participant quality has_specified_input see is_input_of example_of_usage A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. 8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works. PERSON: Alan Ruttenberg PERSON: Bjoern Peters PERSON: Larry Hunter PERSON: Melanie Coutot has_specified_input has_specified_input is_specified_input_of some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. Alan Ruttenberg PERSON:Bjoern Peters is_specified_input_of has_specified_output A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. PERSON: Alan Ruttenberg PERSON: Bjoern Peters PERSON: Larry Hunter PERSON: Melanie Courtot has_specified_output has_specified_output achieves_planned_objective A cell sorting process achieves the objective specification 'material separation objective' This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process. BP, AR, PPPB branch PPPB branch derived modified according to email thread from 1/23/09 in accordince with DT and PPPB branch achieves_planned_objective a 'part of continuant at some time' relation that incides a genome belongs to a organism. Yongqun He, Bin Zhao is genome of organism a relation between a gene and the organism where this gene belongs to the organism in nature. It does not include a foreign gene that is transferred to an organism by a genetic engineering method. Oliver He, Yue Liu is gene of organism has participant this blood coagulation has participant this blood clot this investigation has participant this investigator this process has participant this input material (or this output material) a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant http://www.obofoundry.org/ro/#OBO_REL:has_participant has participant this apple has quality this red color a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. has_quality has quality this person has role this investigator role (more colloquially: this person has this role of investigator) a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. has_role has role RO:0001015 uberon location_of location_of location_of located in my brain is located in my head this rat is located in this cage a relation between two independent continuants, the target and the location, in which the target is entirely within the location Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime located_in http://www.obofoundry.org/ro/#OBO_REL:located_in RO:0001025 uberon located_in located_in located in located_in RO:0002002 uberon has_boundary has_boundary has boundary RO:0002007 uberon bounding_layer_of bounding_layer_of A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane. bounding layer of X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) David Osumi-Sutherland starts_at_end_of A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251]. RO:0002087 directly preceded by is directly preceded by is immediately preceded by starts_at_end_of uberon immediately_preceded_by immediately_preceded_by X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) immediately preceded by immediately_preceded_by RO:0002150 uberon continuous_with continuous_with continuous_with Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. RO:0002170 uberon connected_to connected_to Connection does not imply overlaps. connected to Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect) RO:0002176 uberon connects connects connects x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y RO:0002219 uberon surrounded_by surrounded_by surrounded_by x adjacent_to y iff: x and y share a boundary RO:0002220 uberon adjacent_to adjacent_to adjacent_to inverse of surrounded_by RO:0002221 uberon surrounds surrounds surrounds Relation between occurrents, shares a start boundary with. RO:0002223 uberon starts starts starts Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall started by RO:0002224 uberon starts_with starts_with starts with starts with Relation between occurrents, shares an end boundary with. RO:0002229 finishes uberon ends ends ends x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall finished by RO:0002230 uberon ends_with ends_with ends with ends with RO:0002254 uberon has_developmental_contribution_from has_developmental_contribution_from has developmental contribution from t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. RO:0002256 uberon developmentally_induced_by developmentally_induced_by sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F) developmentally_induced_by RO:0002285 uberon developmentally_replaces developmentally_replaces developmentally_replaces RO:0002351 uberon has_member has_member has member x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y RO:0002385 uberon has_potential_to_developmentally_contribute_to has_potential_to_developmentally_contribute_to has potential to developmentally contribute to x has the potential to develop into y iff x develops into y or if x is capable of developing into y RO:0002387 uberon has_potential_to_develop_into has_potential_to_develop_into has potential to develop into RO:0002433 uberon contributes_to_morphology_of contributes_to_morphology_of contributes to morphology of x composed_primarily_of y iff: more than half of the mass of x is made from parts of y UBREL:0000002 RO:0002473 uberon composed_primarily_of composed_primarily_of composed primarily of Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. BFO:0000068 RO:0002488 begins_to_exist_during uberon existence_starts_during existence_starts_during existence starts during Relation between continuant and occurrent, such that c comes into existence at the start of p. RO:0002489 uberon existence_starts_with existence_starts_with existence starts with Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. BFO:0000069 RO:0002492 ceases_to_exist_during uberon existence_ends_during existence_ends_during existence ends during Relation between continuant and occurrent, such that c ceases to exist at the end of p. RO:0002493 uberon existence_ends_with existence_ends_with existence ends with RO:0002494 transforms from uberon transformation_of transformation_of transformation of RO:0002495 direct_transformation_of immediately transforms from uberon immediate_transformation_of immediate_transformation_of immediate transformation of RO:0002496 uberon existence_starts_during_or_after existence_starts_during_or_after existence starts during or after RO:0002497 uberon existence_ends_during_or_before existence_ends_during_or_before existence ends during or before A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. RO:0002551 uberon has sekeletal support has supporting framework has_skeleton has_skeleton has skeleton RO:0002572 uberon luminal_space_of luminal_space_of luminal space of RO:0002576 uberon skeleton_of skeleton_of skeleton of RO:0003000 uberon produces produces produces RO:0003001 uberon produced_by produced_by produced_by has_vaccine_contraindication is a relation that specifies contraindication of a vaccine. This relation may be replaced by has_vaccine_allergen. We need to determine if any vaccine contraindicator is not a vaccine allergen. YH has vaccine contraindication a object property that specifies a relation between a vaccine and a vaccine allergen YH has vaccine allergen an object property that specifies a relation between a vaccine and a vaccinate route vaccinated in route YL Yongqun He vaccine immunization for host Yongqun He vaccine immunization against microbe Erica Marcos Jiangan Xie Yongqun "Oliver" He (YH) 04-11-2016 OVAE is a biomedical ontology in the area of vaccine adverse events. OVAE is an extension of the community-based Ontology of Adverse Events (OAE). OWL-DL A biomedical ontology in the area of vaccine adverse events. OVAE: Ontology of Vaccine Adverse Events Vision Release: 1.0.34 x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. uberon anteriorly_connected_to anteriorly connected to carries uberon channel_for channel for x is a conduit for y iff y passes through the lumen of x. uberon conduit_for conduit for x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. uberon distally_connected_to distally connected to uberon evolved_from Status: experimental evolved_from uberon existence_starts_and_ends_during existence starts and ends during uberon extends_fibers_into extends_fibers_into x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. uberon posteriorly_connected_to posteriorly connected to uberon protects protects x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. uberon proximally_connected_to proximally connected to uberon subdivision_of placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B subdivision of