The Parkinson Movement Disease Ontology (PMDO) is an application ontology developed to support epilepsy focused informatics tools for patient care and clinical research. PMDO is released by the Case Western Reserve University, Cleveland, OH, USA and University of Vermont Medical Center under the Creative Commons Non-Commercial, Share Alike and Unported License. Authors: Deepak K. Gupta, Satya S. Sahoo Contributors: Raj Contact: satya.sahoo at case.edu Updated with rating scale components Specialization of partonomy to reflect constituent Models generic partonomy information Gene ID: 23400 ATPase cation transporting 13A2 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30213 https://www.ncbi.nlm.nih.gov/gene/23400 ADL AlteredAlertness RXCUI 6033 http://purl.bioontology.org/ontology/RXNORM/620 RXCUI 214624 http://purl.bioontology.org/ontology/RXNORM/1043 http://purl.bioontology.org/ontology/SNOMEDCT/20262006 http://purl.bioontology.org/ontology/RXNORM/2019 http://purl.bioontology.org/ontology/RXNORM/103990 <Add description of clinical feature> Gene ID: 100136349 dj-1 protein https://www.ncbi.nlm.nih.gov/gene/100136349 Gene ID: 9829 DnaJ heat shock protein family (Hsp40) member C6 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15469 https://www.ncbi.nlm.nih.gov/gene/9829 ESS Gene ID: 25793 F-box protein 7 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13586 https://www.ncbi.nlm.nih.gov/gene/?term=FBX07 Gene ID: 2629 glucosylceramidase beta https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4177 https://www.ncbi.nlm.nih.gov/gene/2629 Gene ID: 2643 GTP cyclohydrolase 1 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4193 https://www.ncbi.nlm.nih.gov/gene/2643 Gene ID: 120892 leucine rich repeat kinase 2 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18618 https://www.ncbi.nlm.nih.gov/gene/120892 Gene ID: 4137 microtubule associated protein tau https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6893 https://www.ncbi.nlm.nih.gov/gene/4137 MMSE ADL MoCA MDS-UPDRS Gene ID: 65018 PTEN induced kinase 1 https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14581 https://www.ncbi.nlm.nih.gov/gene/65018 Gene ID: 8398 phospholipase A2 group VI https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9039 https://www.ncbi.nlm.nih.gov/gene/8398 Gene ID: 5071 parkin RBR E3 ubiquitin protein ligase https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8607 https://www.ncbi.nlm.nih.gov/gene/5071 1 1 1 Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia (slowed movements), rigidity, and postural instability. PDQ-39 http://purl.bioontology.org/ontology/RXNORM/746741 RBDSQ RXCUI 134748 RXCUI 2046690 RXCUI 2053470 RXCUI 2058655 RXCUI 2059209 RXCUI 2166156 RXCUI 348025 http://purl.bioontology.org/ontology/RXNORM/134748 This class (and its subclasses) model the variables used in clinical practice to evaluate different aspects of a patient. The primary function of this class is to facilitate data annotation for ontology-based data access (OBDA). rOPINIRole http://purl.bioontology.org/ontology/RXNORM/72302 Gene ID: 6622 synuclein alpha https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11138 https://www.ncbi.nlm.nih.gov/gene/6622 Normal eye movement RXCUI 9639 http://purl.bioontology.org/ontology/RXNORM/9639 Macro Square Wave Jerks UPSIT Gene ID: 55737 VPS35 retromer complex component https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13487 https://www.ncbi.nlm.nih.gov/gene/55737 AbnormalDiagnosticTestResult AbnormalMuscleStrength AbsenceofMotorProgression 5 AbsenceofMotorProgressionRefFlagCriteria MDS-PD red flag criteria 2 Agitation Agraphesthesia AmantadineHydrochloride AmantadineSulfate AnatomicalStructure AncillarySupportiveCriteria MDS-PD ancillary supportive criteria MDS-PD supportive criteria 4 Anipryl AnomicAphasia Anosmia Complete loss of sense of smell AnteriorDirectionality Anterocollis Aphasia Apokyn ApomorphineHydrochloride Apraxia Astereognosis Attention AutonomicDysfunction AutonomicDysfunctionRedFlagCriteria MDS-PD red flag criteria 5 AutonomicFunction Azilect BehavioralProblem BehavioralVariantofFrontotemporalDementia Behavioral variant of frontotemporal dementia http://purl.bioontology.org/ontology/SNOMEDCT/716994006 BilaterallySymmetricParkinsonism BilaterallySymmetricParkinsonismRedFlagCriteria MDS-PD red flag criteria 10 BodilyFeature BowelMovement BradyKinesiaofLowerLimb BradyKinesiaofLowerLimbLeft BradyKinesiaofLowerLimbRight BradyKinesiaofUpperLimbLeft BradyKinesiaofUpperLimbRight BradykinesiaofLimb Bradykinesia means slowness of movement and is one of the cardinal manifestations of Parkinson's disease. BradykinesiaofUpperLimb 4 4 BulbarDysfunctionRedFlagCriteria MDS-PD red flag criteria 3 CardiacSympatheticDenervation CerebellarAbnormalityAbsoluteExclusionCriteria MDS-PD absolute exclusion criteria 1 ClassificationScheme ClinicalAssessment ClinicalClassificationState The current state or outcome of a patient based on a clinical classification scheme. 30 ClinicalEstablishedParkinsonDisease Clinically Established PD ClinicalProbableParkinsonDisease Clinically Probable PD Contractures ContracturesofFeet ContracturesofHand CorticalSensorySign CorticalSignsAbsoluteExlusionCriteria MDS-PD absolute exclusion criteria 7 CorticobasalDegeneration Date Date (format): MM/DD/YYYY This class is used for all computations of time (duration) in this ontology Dementia DepthDirectionality DiagnosticTestResult Diarrhea Dimensionality Models information about dimension of measurement or task Directionality Disease Diurnal DopaNonresponsiveParkinsonism Dopamine non responsive parkisonism DopaNonresponsiveParkinsonismAbsoluteExclusionCriteria MDS-PD absolute exclusion criteria 6 DopaminergicDenervationAbsoluteExclusionCriteria MDS-PD absolute exclusion criteria 8 DopaminergicTherapyResponse Dopamine response DopaminergicTherapyResponseSupportiveCriteria MDS-PD supportive criteria 1 Down-beatingNystagmus Down-beating Nystagmus DownwardGazeAbnormalityAbsoluteExclusionCriteria MDS-PD absolute exclusion criteria 2 DownwardVerticalDirectionality DrugInducedParkinsonism DrugInducedParkinsonismAbsoluteExclusionCriteria MDS-PD absolute exclusion criteria 5 Duopa Dysdiadochokinesia Dysmetria Dysnergia Dysphagia Dysphonia DystonicContracturesRedFlagCriteria MDS-PD red flag criteria 7 Eldepryl Emsam EpworthSleepinessScaleComponent Errection Executive ExpertAssessmentAbsoluteExclusionCriteria MDS-PD absolute exclusion criteria 9 ExpertDiagnosticAssessment ExpiratoryStridor ExpressiveAphasia EyeMovementTask Falls FingertoNoseTask FTN FrontotemporalDegeneration http://purl.bioontology.org/ontology/SNOMEDCT/230273006 5 5 FrontotemporalDegenerationAbsoluteExclusionCriteria MDS-PD absolute exclusion criteria 3 FrontotemporalDementia http://purl.bioontology.org/ontology/SNOMEDCT/230270009 GaitAtaxia GaitTask GazePalsy Gocovri HealtoShinTask HTS HorizontalDirectionality HumanBodyPart HypermetricSaccades HypometricSaccades Hyposmia Partial or reduced sense of smell ImagingFeature ImmaterialAnatomicalEntity Inbrija InspiratoryRespiratoryDysfunctionRedFlagCriteria MDS-PD red flag criteria 4 InspiratoryStridor Kynmobi Laterality LeftLaterality Left Levodopa RXCUI 6375 http://purl.bioontology.org/ontology/RXNORM/6375 LevodopaInducedDyskinesia LevodopaInducedDyskinesiaSupportiveCriteria MDS-PD supportive criteria 2 LewyBodyDisease Libido LimbIdeomotorApraxia LimbRestTremorSupportiveCriteria MDS-PD supportive criteria 3 Lodosyn LowerBodyParkinsonism 3 LowerBodyParkinsonismAbsoluteExclusionCriteria MDS-PD absolute exclusion criteria 4 LowerLimbDysdiadochokinesia MDS-PDCriteria International Parkinson and Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease InternationalParkinsonandMovementDisorderSocietyClinicalDiagnosticCriteriaforParkinson'sDisease MDS-PD_AbsoluteExclusionCriteria MDS-PD_EssentialCriteria MDS-PD_RedFlag MDS-PD_SupportiveCriteria MaterialAnatomicalEntity Meta-IodoBenzylGuanidineScan MIBG MIBG scintigraphy MidlineLaterality Midline MildCognitiveImpairment MCI MiniMentalStatusExaminationComponent Mirapex ModifiedSchwabEnglandActivitiesofDailyLivingScaleComponent MonthOrientationStatus MoodDisorder MovementDisorderSocietyUnifiedParkinsonsDiseaseRatingScaleComponent MovementDisorderSocietyUnifiedParkinsonsDiseaseRatingScaleComponent_PartI MovementDisorderSocietyUnifiedParkinsonsDiseaseRatingScaleComponent_PartII MovementDisorderSocietyUnifiedParkinsonsDiseaseRatingScaleComponent_PartIII MovementDisorderSocietyUnifiedParkinsonsDiseaseRatingScaleComponent_PartIV MultipleSystemAtrophy MuscleToneRigidityofLimb MuscleToneRigidityofLowerLimb MuscleToneRigidityofLowerLimbLeft MuscleToneRigidityofLowerLimbRight MuscleToneRigidityofNeck MuscleToneRigidityofUpperLimb MuscleToneRigidityofUpperLimbLeft MuscleToneRigidityofUpperLimbRight NeurogenicOrthostaticHypotension NeurolepticSensitivity 5 NoNonFeaturesRedFlagCriteria MDS-PD red flag criteria 8 NoNonMotorFeatures Nocturnal NonNeurogenicOrthostaticHypotension Non-neurogenic Orthostatic Hypotension NonPyramidalMuscleWeakness NonSevereDysphagia NonSevereUrinaryIncontinence NonSevereUrinaryRetention NonrecurrentFalls NormalDiagnosticTestResult NormalMuscleStrength NormalSaccades NotParkinsonDisease Not PD OffPeriodDyskinesia OrientationStatus OrthostaticHypotension Osmolex Pain ParkinsonDisease PD ParkinsonismEssentialCriteria ParkinsonsDiseaseQuestionnaire39Component 4 PathologicHyperreflexia PeripheralSensorySign PhaseofDay PlanterReflex Planter sign PosteriorDirectionality PramipexoleDihydrochloride http://purl.bioontology.org/ontology/RXNORM/236747 PrimaryGazeTask ProgressiveAphasia http://purl.bioontology.org/ontology/SNOMEDCT/230278002 ProgressiveSupnuclearPalsy Psychosis PursuitEyeMovementTask PyramidalMuscleWeakness PyramidalSignsRedFlagCriteria MDS-PD red flag criteria 9 RapidEyeMovementSleepBehaviorDisorderScreeningQuestionnaireComponent 5 RapidGaitImpairmentRedFlagCriteria MDS-PD red flag criteria 1 RasagilineMesylate ReceptiveAphasia RecurrentFalls 3 RecurrentFallsRedFlagCriteria MDS-PD red flag criteria 6 Requip Respiratory RestTremorofLimb RestTremorofLowerLimb RestTremorofLowerLimbLeft RestTremorofLowerLimbRight RestTremorofUpperLimb RestTremorofUpperLimbLeft RestTremorofUpperLimbRight RightLaterality Right RopiniroleHydrochloride RXCUI 236553 http://purl.bioontology.org/ontology/RXNORM/236553 Rytary SaccadeEyeMovementTask SaccadicEyeMovementTask SaccardicSmoothPursuit SelegilineHydrochloride RXCUI 1429994 RXCUI 203137 http://purl.bioontology.org/ontology/RXNORM/203137 SensorySign Sensory SevereDysphagia SevereGaitImpairment SevereGaitImpairmentwithCane SevereGaitImpairmentwithWalker SevereGaitImpairmentwithWheelChair SevereUrinaryIncontinence SevereUrinaryRetention SexualFunction SexuallyInappropriateBehavior Sinemet SittingTask Sleep SlowSaccades SlowSmoothPursuit Smell SociallyInappropriateBehavior Stalevo StoolConsistency StoolFrequency Stridor SustainedGaze-EvokedNystagmus Sustained Gaze-Evoked Nystagmus SympatheticDenervation Timestamp Time (format): HH:MM (24 hours) This class is used for all computations of time (duration) in this ontology. TruncalAtaxia UnitedKingdomBrainBankCriteria UK Brain Bank Criteria UKBB Criteria UniversityofPennsylvaniaSmellIdentificationTestComponent UpperLimbDysdiadochokinesia UpwardVerticalDirectionality UrinaryRetention VerticalDirectionality Visuospatial Zelapar code_education_12years_complete code_ess0101_sitting_and_reading code_ess0102_watching_tv code_ess0103_sitting_inactive_in_public_place code_ess0104_passenger_in_car_for_hour code_ess0105_lying_down_to_rest_in_afternoon code_ess0106_sitting_and_talking_to_someone code_ess0107_sitting_after_lunch code_ess0108_car_stopped_in_traffic code_mms101a_year code_mms101b_season code_mms101c_month code_mms101d_day code_mms101e_date code_mms102a_state code_mms102b_county code_mms102c_city code_mms102d_address code_mms102e_floor code_rbd01_vivid_dreams code_rbd02_aggressive_or_action_packed_dreams code_rbd03_nocturnal_behaviour code_rbd04_move_arms_legs_during_sleep code_rbd05_hurt_bed_partner code_rbd06_1_speaking_in_sleep code_rbd06_2_sudden_limb_movements code_rbd06_3_complex_movements code_rbd06_4_things_fell_down code_rbd07_my_movements_awake_me code_rbd08_remember_dreams code_rbd09_sleep_is_disturbed code_rbd10_nervous_system_disease code_rbd10a_stroke code_rbd10b_head_trauma code_rbd10c_parkinsonism code_rbd10d_rls code_rbd10e_narcolepsy code_rbd10f_depression code_rbd10g_epilepsy code_rbd10h_brain_inflammatory_disease code_rbd10i_other code_rbd_info_source code_upd2101_cognitive_impairment code_upd2102_hallucinations_and_psychosis code_upd2103_depressed_mood code_upd2104_anxious_mood code_upd2105_apathy code_upd2106_dopamine_dysregulation_syndrome_features code_upd2107_pat_quest_sleep_problems code_upd2108_pat_quest_daytime_sleepiness code_upd2109_pat_quest_pain_and_other_sensations code_upd2110_pat_quest_urinary_problems code_upd2111_pat_quest_constipation_problems code_upd2112_pat_quest_lightheadedness_on_standing code_upd2113_pat_quest_fatigue code_upd2201_speech code_upd2202_saliva_and_drooling code_upd2203_chewing_and_swallowing code_upd2204_eating_tasks code_upd2205_dressing code_upd2206_hygiene code_upd2207_handwriting code_upd2208_doing_hobbies_and_other_activities code_upd2209_turning_in_bed code_upd2210_tremor code_upd2211_get_out_of_bed_car_or_deep_chair code_upd2212_walking_and_balance code_upd2213_freezing code_upd2301_speech_problems code_upd2302_facial_expression code_upd2303a_rigidity_neck code_upd2303b_rigidity_rt_upper_extremity code_upd2303c_rigidity_left_upper_extremity code_upd2303d_rigidity_rt_lower_extremity code_upd2303e_rigidity_left_lower_extremity code_upd2304a_right_finger_tapping code_upd2304b_left_finger_tapping code_upd2305a_right_hand_movements code_upd2305b_left_hand_movements code_upd2306a_pron_sup_movement_right_hand code_upd2306b_pron_sup_movement_left_hand code_upd2307a_right_toe_tapping code_upd2307b_left_toe_tapping code_upd2308a_right_leg_agility code_upd2308b_left_leg_agility code_upd2309_arising_from_chair code_upd2310_gait code_upd2311_freezing_of_gait code_upd2312_postural_stability code_upd2313_posture code_upd2314_body_bradykinesia code_upd2315a_postural_tremor_of_right_hand code_upd2315b_postural_tremor_of_left_hand code_upd2316a_kinetic_tremor_of_right_hand code_upd2316b_kinetic_tremor_of_left_hand code_upd2317a_rest_tremor_amplitude_right_upper_extremity code_upd2317b_rest_tremor_amplitude_left_upper_extremity code_upd2317c_rest_tremor_amplitude_right_lower_extremity code_upd2317d_rest_tremor_amplitude_left_lower_extremity code_upd2317e_rest_tremor_amplitude_lip_or_jaw code_upd2318_consistency_of_rest_tremor code_upd2401_time_spent_with_dyskinesias code_upd2402_functional_impact_of_dyskinesias code_upd2403_time_spent_in_the_off_state code_upd2404_functional_impact_of_fluctuations code_upd2405_complexity_of_motor_fluctuations code_upd2406_painful_off_state_dystonia code_upd2hy_hoehn_and_yahr_stage ess0101_sitting_and_reading ess0102_watching_tv ess0103_sitting_inactive_in_public_place ess0104_passenger_in_car_for_hour ess0105_lying_down_to_rest_in_afternoon ess0106_sitting_and_talking_to_someone ess0107_sitting_after_lunch ess0108_car_stopped_in_traffic ess_info_source ess_summary_score mds_updrs_part_i_pat_quest_primary_info_source mds_updrs_part_i_pat_quest_sub_score mds_updrs_part_i_primary_info_source mds_updrs_part_i_sub_score mds_updrs_part_i_summary_score mds_updrs_part_ii_primary_info_source mds_updrs_part_ii_summary_score mds_updrs_part_iii_summary_score mds_updrs_part_iv_summary_score mms103_repeat_objects_score mms104_attention_calculat_score mms105_recall_score mms106_naming_object_score mms107_repeat_phrase_score mms108b_fold_in_half_score mms109_close_eyes_score mms110_sentence_score mms111_copy_design_score mms112_total_score moca01_alternating_trail_making moca02_visuoconstr_skills_cube moca03_visuoconstr_skills_clock_cont moca05_visuoconstr_skills_clock_hands moca06_naming_lion moca07_naming_rhino moca08_naming_camel moca09_attention_forward_digit_span moca10_attention_backward_digit_span moca11_attention_vigilance moca12_attention_serial_7s moca13_sentence_repetition moca14_verbal_fluency_number_of_words moca15_verbal_fluency moca16_abstraction moca17_delayed_recall_face moca18_delayed_recall_velvet moca19_delayed_recall_church moca20_delayed_recall_daisy moca21_delayed_recall_red moca22_orientation_date_score moca23_orientation_month_score moca24_orientation_year_score moca25_orientation_day_score moca26_orientation_place_score moca27_orientation_city_score moca_abstraction_subscore moca_attention_digits_subscore moca_delayed_recall_subscore moca_delayed_recall_subscore_optnl_cat_cue moca_delayed_recall_subscore_optnl_mult_choice moca_language_subscore moca_naming_subscore moca_orientation_subscore moca_total_score moca_visuospatial_executive_subscore mod_schwab_england_on_off_med mod_schwab_england_pct_adl_score pdq39_adl_score pdq39_cognition_score pdq39_communication_score pdq39_discomfort_score pdq39_emotional_score pdq39_mobility_score pdq39_social_score pdq39_stigma_score rbd_summary_score score_from_booklet_1 score_from_booklet_2 score_from_booklet_3 score_from_booklet_4 upd23a_medication_for_pd upd23b_clinical_state_on_medication upd2da_dyskinesias_during_exam upd2db_movements_interfere_with_ratings upsit_performed upsit_total_score owl:Thing The Parkinson Movement Disease Ontology (PMDO) is an application ontology developed to support epilepsy focused informatics tools for patient care and clinical research. PMDO is released by the Case Western Reserve University, Cleveland, OH, USA and University of Vermont Medical Center under the Creative Commons Non-Commercial, Share Alike and Unported License. Authors: Deepak K. Gupta, Satya S. Sahoo Contributors: Raj Contact: satya.sahoo at case.edu Updated with rating scale components