13:06:2021 12:12 PSI-MOD 1.2 Joshua Klein Annotation note 01 - "[PSI-MOD:ref]" has been replaced by PubMed:18688235. Annotation note 02 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by a hash symbol "#" and a 3 or 4 character label. When an entry in the RESID Database is annotated as a general modification with the same enzymatic activity producing different chemical structures depending on natural variation in the nonproteinaceous substrate, on secondary modifications that do not change the nature of the primary modification, or on a combination of a primary and one or more secondary modifications on the same residue, then the PSI-MOD definition for each different instance carries the RESID cross-reference followed by the special tag "#var". Annotation note 03 - When an entry in the Unimod database is annotated as a general modification, and one or more instance sites are listed, then the PSI-MOD definition for each different site instance carries the Unimod cross-reference followed by a hash symbol and an amino acid code, "N-term" or "C-term". Annotation note 04 - The elemental formulas are in strict alphabetical order, not in CAS ("C" and "H" first) order. Isotope numbers are in parentheses before the element symbol, and an element should not occur in a formula both with and without an isotope number. In difference formulas, counts can be zero or negative. Annotation note 05 - In entries with an isotope indicator in the formula, average masses are meaningless and are assigned the value equal to the monoisotopic mass, but rounded to a lower precision; monoisotopic masses are calculated by using the masses for the indicated isotopes and the most common isotopes for other elements without isotope indicators in the formulas. Annotation note 06 - For cross-link modifications, the number following "Cross-link" in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. This usage differs from RESID, where the cross-link number indicates the maximum number of peptide chains that can be cross-linked. Annotation note 07 - The synonym cross-reference "MOD:old name" has been replaced by "MOD:alternate name". Annotation note 08 - The DeltaMass listings for free amino acids have been removed. Most Unimod entries that have not been "approved" have by general agreement not been incorporated unless there has been a request for a specific term by a PRIDE submitter. Annotation note 09 - The Open Mass Spectrometry Search Algorithm, OMSSA, enumerated list of modifications are being incorporated. The string values are synonyms with the synonymtypedef "OMSSA-label", and their integer values (which are supposed to be stable) are definition cross-references. Annotation note 10 - GNOme is the Glycan Naming and Subsumption Ontology (https://gnome.glyomics.org/), an ontology for the support of glycomics. PSI-MOD does not have all possible glycans in its entries, just the ones that are noted to be on proteins and have been requested for addition. GNOme uses GlyTouCan (http://glytoucan.org/) to provide stable accessions for glycans described at varyious degrees of characterization, including compositions (no linkage) and topologies (no carbon bond positions or anomeric configurations). ISO-8601 date: 2022-06-13 12:12Z PSI-MOD version: 1.031.6 RESID release: 75.00 definition Label from MS DeltaMass Short label from OMSSA Alternate name curated by PSI-MOD Short label curated by PSI-MOD subset of protein modifications Agreed label from MS community Alternate name from RESID Misnomer tagged alternate name from RESID Name from RESID Systematic name from RESID Protein feature description from UniProtKB Alternate name from Unimod Description (full_name) from Unimod Interim label from Unimod subset_property synonym_type_property database_cross_reference has_exact_synonym has_obo_format_version has_obo_namespace has_related_synonym has_scope has_synonym_type in_subset 'Entity A' contains 'Entity B' implies that 'Entity B' is a part of the structure of 'Entity A'. PSI-MOD contains The inverse relationship to "part of". contains 'Entity A' contains 'Entity B' implies that 'Entity B' is a part of the structure of 'Entity A'. PubMed:18688235 'Entity A' part_of 'Entity B' implies that 'Entity A' is a part of the structure of 'Entity B'. PSI-MOD part_of part of 'Entity A' part_of 'Entity B' implies that 'Entity A' is a part of the structure of 'Entity B'. PubMed:18688235 Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue. ModRes PSI-MOD MOD:00000 protein modification MOD:00000 Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue. PubMed:18688235 ModRes A protein modification that effectively replaces a hydrogen atom with an alkyl group. Source: AlkylRes PSI-MOD MOD:00001 alkylated residue MOD:00001 A protein modification that effectively replaces a hydrogen atom with an alkyl group. PubMed:18688235 Source: none AlkylRes A protein modification that effectively converts an L-serine residue to O3-glycosylserine. Origin: Source: TermSpec: OGlycoSer PSI-MOD MOD:00002 O-glycosyl-L-serine MOD:00002 Source: natural TermSpec: none OGlycoSer A protein modification that effectively converts an L-serine residue to O3-glycosylserine. PubMed:18688235 Origin: S Entry from Unimod. Source: PSI-MOD MOD:00003 This term is for organizational use only and should not be assigned. [JSG] Unimod MOD:00003 Entry from Unimod. PubMed:18688235 Source: none Artifact entry from Unimod - OBSOLETE because organizational use is no longer required. PSI-MOD MOD:00004 artifact true MOD:00004 Artifact entry from Unimod - OBSOLETE because organizational use is no longer required. PubMed:18688235 A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine. Origin: Source: TermSpec: OGlycoThr PSI-MOD MOD:00005 O-glycosyl-L-threonine MOD:00005 A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine. PubMed:18688235 Origin: T Source: natural TermSpec: none OGlycoThr A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond. Source: NGlycoRes PSI-MOD MOD:00006 N-glycosylated residue MOD:00006 A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond. PubMed:18688235 Source: none NGlycoRes A protein modification that effectively substitutes a selenium atom for a sulfur atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Se(S)Res PSI-MOD Delta:S(-1)Se(1) Selenium replaces sulphur MOD:00007 selenium substitution for sulfur MOD:00007 A protein modification that effectively substitutes a selenium atom for a sulfur atom. PubMed:12148805 Unimod:162 DiffAvg: 46.91 DiffFormula: C 0 H 0 N 0 O 0 S -1 Se 1 DiffMono: 47.944450 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:162 Se(S)Res Delta:S(-1)Se(1) Selenium replaces sulphur Entry from Unimod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required. PSI-MOD MOD:00008 common true MOD:00008 Entry from Unimod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required. PubMed:18688235 A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue. Origin: Source: Res alpha-amino acid PSI-MOD MOD:00009 natural residue MOD:00009 A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue. PubMed:6692818 RESID:AA0000 Origin: X Source: natural Res alpha-amino acid A protein modification that effectively converts a source amino acid residue to an L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-aminopropanoic acid 2-aminopropionic acid 2-azanylpropanoic acid Ala L-alanine alpha-alanine alpha-aminopropionic acid PSI-MOD MOD:00010 L-alanine residue MOD:00010 A protein modification that effectively converts a source amino acid residue to an L-alanine. ChEBI:29948 DeltaMass:0 PubMed:6692818 RESID:AA0001 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 3 H 5 N 1 O 1 MassAvg: 71.08 MassMono: 71.037114 Origin: A Source: natural TermSpec: none (2S)-2-aminopropanoic acid 2-aminopropionic acid 2-azanylpropanoic acid Ala L-alanine alpha-alanine alpha-aminopropionic acid A protein modification that effectively converts a source amino acid residue to an L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid 2-amino-5-(carbamimidamido)pentanoic acid [tautomer] 2-amino-5-[(aminoiminomethyl)amino]pentanoic acid [tautomer] 2-amino-5-guanidinopentanoic acid 2-amino-5-guanidinovaleric acid 2-azanyl-5-[bis(azanyl)methylideneazanyl]pentanoic acid Arg L-arginine alpha-amino-delta-guanidinovaleric acid PSI-MOD MOD:00011 L-arginine residue MOD:00011 A protein modification that effectively converts a source amino acid residue to an L-arginine. ChEBI:29952 DeltaMass:0 PubMed:518876 PubMed:6692818 RESID:AA0002 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 6 H 12 N 4 O 1 MassAvg: 156.19 MassMono: 156.101111 Origin: R Source: natural TermSpec: none (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid 2-amino-5-(carbamimidamido)pentanoic acid [tautomer] 2-amino-5-[(aminoiminomethyl)amino]pentanoic acid [tautomer] 2-amino-5-guanidinopentanoic acid 2-amino-5-guanidinovaleric acid 2-azanyl-5-[bis(azanyl)methylideneazanyl]pentanoic acid Arg L-arginine alpha-amino-delta-guanidinovaleric acid A protein modification that effectively converts a source amino acid residue to an L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-butanediamic acid 2,4-bis(azanyl)-4-oxobutanoic acid 2,4-diamino-4-oxobutanoic acid 2-amino-3-carbamoylpropanoic acid 2-amino-4-butanediamic acid 2-aminosuccinamic acid 2-aminosuccinic acid 4-amide Asn L-asparagine alpha-amino-beta-carbamylpropionic acid alpha-aminosuccinamic acid aspartic acid 4-amide aspartic acid beta-amide beta-asparagine PSI-MOD MOD:00012 L-asparagine residue MOD:00012 alpha-aminosuccinamic acid aspartic acid 4-amide aspartic acid beta-amide beta-asparagine A protein modification that effectively converts a source amino acid residue to an L-asparagine. ChEBI:29956 DeltaMass:0 PubMed:15736973 PubMed:5681232 PubMed:6692818 PubMed:9789001 RESID:AA0003 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 4 H 6 N 2 O 2 MassAvg: 114.10 MassMono: 114.042927 Origin: N Source: natural TermSpec: none (2S)-2-amino-4-butanediamic acid 2,4-bis(azanyl)-4-oxobutanoic acid 2,4-diamino-4-oxobutanoic acid 2-amino-3-carbamoylpropanoic acid 2-amino-4-butanediamic acid 2-aminosuccinamic acid 2-aminosuccinic acid 4-amide Asn L-asparagine alpha-amino-beta-carbamylpropionic acid A protein modification that effectively converts a source amino acid residue to an L-aspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-aminobutanedioic acid 2-azanylbutanedioic acid Asp L-aspartic acid aminosuccinic acid PSI-MOD MOD:00013 L-aspartic acid residue MOD:00013 A protein modification that effectively converts a source amino acid residue to an L-aspartic acid. ChEBI:29958 DeltaMass:0 PubMed:1097438 PubMed:339692 PubMed:4399050 PubMed:5764436 PubMed:6692818 PubMed:8089117 PubMed:9521123 PubMed:9582379 RESID:AA0004 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 4 H 5 N 1 O 3 MassAvg: 115.09 MassMono: 115.026943 Origin: D Source: natural TermSpec: none (2S)-2-aminobutanedioic acid 2-azanylbutanedioic acid Asp L-aspartic acid aminosuccinic acid A protein modification that effectively converts a source amino acid residue to an L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-sulfanylpropanoic acid (R)-cysteine 2-amino-3-mercaptopropanoic acid 2-amino-3-mercaptopropionic acid 2-azanyl-3-sulfanylpropanoic acid 3-mercapto-L-alanine Cys Cysteine (C, Cys) L-(+)-cysteine L-cysteine alpha-amino-beta-mercaptopropanoic acid alpha-amino-beta-mercaptopropionic acid alpha-amino-beta-thiolpropionic acid beta-mercaptoalanine half-cystine thioserine PSI-MOD MOD:00014 From DeltaMass: Average Mass: 121. L-cysteine residue MOD:00014 A protein modification that effectively converts a source amino acid residue to an L-cysteine. ChEBI:29950 DeltaMass:0 PubMed:1310545 PubMed:15790858 PubMed:3447159 PubMed:6692818 PubMed:7338899 RESID:AA0005 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 S 0 DiffMono: 0.000000 Formula: C 3 H 5 N 1 O 1 S 1 MassAvg: 103.14 MassMono: 103.009185 Origin: C Source: natural TermSpec: none (2R)-2-amino-3-sulfanylpropanoic acid (R)-cysteine 2-amino-3-mercaptopropanoic acid 2-amino-3-mercaptopropionic acid 2-azanyl-3-sulfanylpropanoic acid 3-mercapto-L-alanine Cys Cysteine (C, Cys) L-(+)-cysteine L-cysteine alpha-amino-beta-mercaptopropanoic acid alpha-amino-beta-mercaptopropionic acid alpha-amino-beta-thiolpropionic acid beta-mercaptoalanine half-cystine thioserine A protein modification that effectively converts a source amino acid residue to an L-glutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-aminopentanedioic acid 1-aminopropane-1,3-dicarboxylic acid 2-aminoglutaric acid 2-azanylpentanedioic acid Glu L-glutamic acid alpha-aminoglutaric acid glutaminic acid PSI-MOD MOD:00015 L-glutamic acid residue MOD:00015 A protein modification that effectively converts a source amino acid residue to an L-glutamic acid. ChEBI:29972 DeltaMass:0 PubMed:1881881 PubMed:4565668 PubMed:4922541 PubMed:6692818 PubMed:9326660 PubMed:957425 RESID:AA0006 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: E Source: natural TermSpec: none (2S)-2-aminopentanedioic acid 1-aminopropane-1,3-dicarboxylic acid 2-aminoglutaric acid 2-azanylpentanedioic acid Glu L-glutamic acid alpha-aminoglutaric acid glutaminic acid A protein modification that effectively converts a source amino acid residue to an L-glutamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-pentanediamic acid 2,5-bis(azanyl)-5-oxopentanoic acid 2,5-diamino-5-oxopentanoic acid 2-amino-4-carbamoylbutanoic acid 2-aminoglutaramic acid Gln L-glutamine alpha-amino-gamma-carbamylbutyric acid glutamic acid 5-amide glutamic acid gamma-amide glutamide PSI-MOD MOD:00016 L-glutamine residue MOD:00016 A protein modification that effectively converts a source amino acid residue to an L-glutamine. ChEBI:30011 DeltaMass:0 PubMed:3340166 PubMed:6692818 PubMed:9342308 RESID:AA0007 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 5 H 8 N 2 O 2 MassAvg: 128.13 MassMono: 128.058578 Origin: Q Source: natural TermSpec: none (2S)-2-amino-5-pentanediamic acid 2,5-bis(azanyl)-5-oxopentanoic acid 2,5-diamino-5-oxopentanoic acid 2-amino-4-carbamoylbutanoic acid 2-aminoglutaramic acid Gln L-glutamine alpha-amino-gamma-carbamylbutyric acid glutamic acid 5-amide glutamic acid gamma-amide glutamide A protein modification that effectively converts a source amino acid residue to a glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Gly aminoacetic acid aminoethanoic acid azanylethanoic acid glycine glycocoll PSI-MOD MOD:00017 glycine residue MOD:00017 A protein modification that effectively converts a source amino acid residue to a glycine. ChEBI:29947 DeltaMass:0 PubMed:1310545 PubMed:6692818 RESID:AA0008 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 2 H 3 N 1 O 1 MassAvg: 57.05 MassMono: 57.021464 Origin: G Source: natural TermSpec: none Gly aminoacetic acid aminoethanoic acid azanylethanoic acid glycine glycocoll A protein modification that effectively converts a source amino acid residue to an L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid [tautomer] 2-azanyl-3-(1H-imidazol-4-yl)propanoic acid 2-azanyl-3-(1H-imidazol-5-yl)propanoic acid [tautomer] 4-(2-amino-2-carboxyethyl)imidazole His L-histidine alpha-amino-beta-(4-imidazole)propionic acid glyoxaline-5-alanine PSI-MOD MOD:00018 L-histidine residue MOD:00018 A protein modification that effectively converts a source amino acid residue to an L-histidine. ChEBI:29979 DeltaMass:0 PubMed:14342316 PubMed:2722967 PubMed:512 PubMed:5460889 PubMed:6129252 PubMed:6692818 PubMed:6876174 RESID:AA0009 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 6 H 7 N 3 O 1 MassAvg: 137.14 MassMono: 137.058912 Origin: H Source: natural TermSpec: none (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid [tautomer] 2-azanyl-3-(1H-imidazol-4-yl)propanoic acid 2-azanyl-3-(1H-imidazol-5-yl)propanoic acid [tautomer] 4-(2-amino-2-carboxyethyl)imidazole His L-histidine alpha-amino-beta-(4-imidazole)propionic acid glyoxaline-5-alanine A protein modification that effectively converts a source amino acid residue to an L-isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,3S)-2-amino-3-methylpentanoic acid 2-azanyl-3-methylpentanoic acid 3-methyl-norvaline Ile Isoleucyl L-erythro-isoleucine L-isoleucine alpha-amino-beta-methylvaleric acid PSI-MOD MOD:00019 L-isoleucine residue MOD:00019 A protein modification that effectively converts a source amino acid residue to an L-isoleucine. ChEBI:30009 DeltaMass:0 PubMed:6692818 RESID:AA0010 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 6 H 11 N 1 O 1 MassAvg: 113.16 MassMono: 113.084064 Origin: I Source: natural TermSpec: none (2S,3S)-2-amino-3-methylpentanoic acid 2-azanyl-3-methylpentanoic acid 3-methyl-norvaline Ile Isoleucyl L-erythro-isoleucine L-isoleucine alpha-amino-beta-methylvaleric acid A protein modification that effectively converts a source amino acid residue to an L-leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-methylpentanoic acid 2-azanyl-4-methylpentanoic acid 4-methyl-norvaline L-leucine Leu alpha-amino-gamma-methylvaleric acid alpha-aminoisocaproic acid PSI-MOD MOD:00020 L-leucine residue MOD:00020 A protein modification that effectively converts a source amino acid residue to an L-leucine. ChEBI:30006 DeltaMass:0 PubMed:11478885 PubMed:6692818 RESID:AA0011 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 6 H 11 N 1 O 1 MassAvg: 113.16 MassMono: 113.084064 Origin: L Source: natural TermSpec: none (2S)-2-amino-4-methylpentanoic acid 2-azanyl-4-methylpentanoic acid 4-methyl-norvaline L-leucine Leu alpha-amino-gamma-methylvaleric acid alpha-aminoisocaproic acid A protein modification that effectively converts a source amino acid residue to L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2,6-diaminohexanoic acid 2,6-bis(azanyl)hexanoic acid 6-amino-L-norleucine ACT_SITE Schiff-base intermediate with substrate L-lysine Lys alpha,epsilon-diaminocaproic acid PSI-MOD MOD:00021 L-lysine residue MOD:00021 A protein modification that effectively converts a source amino acid residue to L-lysine. ChEBI:29967 DeltaMass:0 PubMed:3106962 PubMed:6120171 PubMed:6692818 RESID:AA0012 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 6 H 12 N 2 O 1 MassAvg: 128.18 MassMono: 128.094963 Origin: K Source: natural TermSpec: none (2S)-2,6-diaminohexanoic acid 2,6-bis(azanyl)hexanoic acid 6-amino-L-norleucine ACT_SITE Schiff-base intermediate with substrate L-lysine Lys alpha,epsilon-diaminocaproic acid A protein modification that effectively converts a source amino acid residue to L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-(methylsulfanyl)butanoic acid 2-amino-4-(methylthio)butanoic acid 2-amino-4-(methylthio)butyric acid 2-azanyl-4-(methylsulfanyl)butanoic acid L-(-)-methionine L-methionine Met S-methyl-L-homocysteine alpha-amino-gamma-methylmercaptobutyric acid alpha-amino-gamma-methylthiobutyric acid gamma-methylthio-alpha-aminobutyric acid PSI-MOD MOD:00022 From DeltaMass: Average Mass: 149 L-methionine residue MOD:00022 A protein modification that effectively converts a source amino acid residue to L-methionine. ChEBI:29983 DeltaMass:0 PubMed:6411710 PubMed:6692818 RESID:AA0013 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 S 0 DiffMono: 0.000000 Formula: C 5 H 9 N 1 O 1 S 1 MassAvg: 131.19 MassMono: 131.040485 Origin: M Source: natural TermSpec: none (2S)-2-amino-4-(methylsulfanyl)butanoic acid 2-amino-4-(methylthio)butanoic acid 2-amino-4-(methylthio)butyric acid 2-azanyl-4-(methylsulfanyl)butanoic acid L-(-)-methionine L-methionine Met S-methyl-L-homocysteine alpha-amino-gamma-methylmercaptobutyric acid alpha-amino-gamma-methylthiobutyric acid gamma-methylthio-alpha-aminobutyric acid A protein modification that effectively converts a source amino acid residue to L-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-phenylpropanoic acid 2-azanyl-3-phenylpropanoic acid L-phenylalanine Phe alpha-amino-beta-phenylpropionic acid PSI-MOD MOD:00023 L-phenylalanine residue MOD:00023 A protein modification that effectively converts a source amino acid residue to L-phenylalanine. ChEBI:29997 DeltaMass:0 PubMed:6692818 RESID:AA0014 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 9 H 9 N 1 O 1 MassAvg: 147.18 MassMono: 147.068414 Origin: F Source: natural TermSpec: none (2S)-2-amino-3-phenylpropanoic acid 2-azanyl-3-phenylpropanoic acid L-phenylalanine Phe alpha-amino-beta-phenylpropionic acid A protein modification that effectively converts a source amino acid residue to L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-pyrrolidinecarboxylic acid L-proline Pro pyrrolidine-2-carboxylic acid PSI-MOD MOD:00024 L-proline residue MOD:00024 A protein modification that effectively converts a source amino acid residue to L-proline. ChEBI:30017 DeltaMass:0 PubMed:6692818 PubMed:8547259 RESID:AA0015 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 5 H 7 N 1 O 1 MassAvg: 97.12 MassMono: 97.052764 Origin: P Source: natural TermSpec: none (2S)-2-pyrrolidinecarboxylic acid L-proline Pro pyrrolidine-2-carboxylic acid A protein modification that effectively converts a source amino acid residue to L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-hydroxypropanoic acid 2-azanyl-3-hydroxypropanoic acid 3-hydroxy-L-alanine L-serine Ser alpha-amino-beta-hydroxypropionic acid beta-hydroxyalanine PSI-MOD MOD:00025 L-serine residue MOD:00025 A protein modification that effectively converts a source amino acid residue to L-serine. ChEBI:29999 DeltaMass:0 PubMed:4399050 PubMed:6692818 RESID:AA0016 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 3 H 5 N 1 O 2 MassAvg: 87.08 MassMono: 87.032028 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-hydroxypropanoic acid 2-azanyl-3-hydroxypropanoic acid 3-hydroxy-L-alanine L-serine Ser alpha-amino-beta-hydroxypropionic acid beta-hydroxyalanine A protein modification that effectively converts a source amino acid residue to L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,3R)-2-amino-3-hydroxybutanoic acid 2-azanyl-3-hydroxybutanoic acid L-threo-threonine L-threonine Thr alpha-amino-beta-hydroxybutyric acid beta-methylserine PSI-MOD MOD:00026 L-threonine residue MOD:00026 A protein modification that effectively converts a source amino acid residue to L-threonine. ChEBI:30013 DeltaMass:0 PubMed:2989287 PubMed:6692818 RESID:AA0017 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 4 H 7 N 1 O 2 MassAvg: 101.10 MassMono: 101.047678 Origin: T Source: natural TermSpec: none (2S,3R)-2-amino-3-hydroxybutanoic acid 2-azanyl-3-hydroxybutanoic acid L-threo-threonine L-threonine Thr alpha-amino-beta-hydroxybutyric acid beta-methylserine A protein modification that effectively converts a source amino acid residue to L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid 2-azanyl-3-(1H-indol-3-yl)propanoic acid L-tryptophan Trp alpha-amino-beta-(3-indolyl)propionoic acid beta(3-indolyl)alanine PSI-MOD MOD:00027 L-tryptophan residue MOD:00027 A protein modification that effectively converts a source amino acid residue to L-tryptophan. ChEBI:29954 DeltaMass:0 PubMed:2059637 PubMed:6692818 PubMed:9324768 RESID:AA0018 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 11 H 10 N 2 O 1 MassAvg: 186.21 MassMono: 186.079313 Origin: W Source: natural TermSpec: none (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid 2-azanyl-3-(1H-indol-3-yl)propanoic acid L-tryptophan Trp alpha-amino-beta-(3-indolyl)propionoic acid beta(3-indolyl)alanine A protein modification that effectively converts a source amino acid residue to L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-(4-hydoxyphenyl)propanoic acid 2-azanyl-3-(4-hydoxyphenyl)propanoic acid L-tyrosine Tyr alpha-amino-beta-(para-hydroxyphenyl)propionic acid p-tyrosine para-hydroxyphenylalanine PSI-MOD MOD:00028 L-tyrosine residue MOD:00028 A protein modification that effectively converts a source amino acid residue to L-tyrosine. ChEBI:29975 DeltaMass:0 PubMed:2190093 PubMed:2542938 PubMed:5550972 PubMed:6061414 PubMed:6120171 PubMed:6692818 RESID:AA0019 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 9 H 9 N 1 O 2 MassAvg: 163.18 MassMono: 163.063329 Origin: Y Source: natural TermSpec: none (2S)-2-amino-3-(4-hydoxyphenyl)propanoic acid 2-azanyl-3-(4-hydoxyphenyl)propanoic acid L-tyrosine Tyr alpha-amino-beta-(para-hydroxyphenyl)propionic acid p-tyrosine para-hydroxyphenylalanine A protein modification that effectively converts a source amino acid residue to an L-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-methylbutanoic acid 2-azanyl-3-methylbutanoic acid L-valine Val alpha-amino-beta-methylbutyric acid alpha-aminoisovaleric acid PSI-MOD MOD:00029 L-valine residue MOD:00029 A protein modification that effectively converts a source amino acid residue to an L-valine. ChEBI:30015 DeltaMass:0 PubMed:6692818 RESID:AA0020 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 5 H 9 N 1 O 1 MassAvg: 99.13 MassMono: 99.068414 Origin: V Source: natural TermSpec: none (2S)-2-amino-3-methylbutanoic acid 2-azanyl-3-methylbutanoic acid L-valine Val alpha-amino-beta-methylbutyric acid alpha-aminoisovaleric acid A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid 2-formamido-4-(methylsulfanyl)butanoic acid 2-formylamino-4-(methylthio)butanoic acid 2-formylazanyl-4-(methylsulfanyl)butanoic acid MOD_RES N-formylmethionine N-formyl-L-methionine N-formylated L-methionine fMet nformylmet PSI-MOD FormylMet MOD:00030 N-formyl-L-methionine residue MOD:00030 A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification. ChEBI:33718 OMSSA:22 PubMed:10825024 PubMed:11152118 PubMed:2165784 PubMed:3042771 PubMed:8758896 RESID:AA0021#FMET DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 S 0 DiffMono: 0.000000 Formula: C 6 H 10 N 1 O 2 S 1 MassAvg: 160.21 MassMono: 160.043225 Origin: M Source: natural TermSpec: N-term (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid 2-formamido-4-(methylsulfanyl)butanoic acid 2-formylamino-4-(methylthio)butanoic acid 2-formylazanyl-4-(methylsulfanyl)butanoic acid MOD_RES N-formylmethionine N-formyl-L-methionine N-formylated L-methionine fMet nformylmet FormylMet A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-selanylpropanoic acid 2-azanyl-3-selanylpropanoic acid 3-selenylalanine L-selenocysteine NON_STD Selenocysteine SeCys Sec selenium cysteine PSI-MOD MOD:00031 L-selenocysteine residue MOD:00031 A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification. ChEBI:30000 PubMed:10523135 PubMed:1066676 PubMed:2037562 PubMed:2963330 PubMed:4734725 PubMed:6076213 PubMed:6217842 PubMed:6714945 RESID:AA0022 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 Se 0 DiffMono: 0.000000 Formula: C 3 H 5 N 1 O 1 Se 1 MassAvg: 150.05 MassMono: 150.953635 Origin: U Source: natural TermSpec: none (2R)-2-amino-3-selanylpropanoic acid 2-azanyl-3-selanylpropanoic acid 3-selenylalanine L-selenocysteine NON_STD Selenocysteine SeCys Sec selenium cysteine A protein modification that is not chemically categorized. Source: PSI-MOD MOD:00032 This term is for organizational use only and should not be assigned. [JSG] uncategorized protein modification MOD:00032 A protein modification that is not chemically categorized. PubMed:18688235 Source: none A protein modification that crosslinks two or more amino acid residues with covalent bonds. Source: XLNK-Res-Res PSI-MOD MOD:00033 The covalent bond is formed directly between sidechain atoms. If non-aminoacid atoms are involved in connecting two or more peptide chain residues peptide chain, the connection is classified as a multivalent binding site. crosslinked residues MOD:00033 A protein modification that crosslinks two or more amino acid residues with covalent bonds. PubMed:18688235 Source: none XLNK-Res-Res A protein modification that effectively cross-links two L-cysteine residues to form L-cystine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) 3,3'-dithiobis(2-aminopropanoic acid) 3,3'-dithiobisalanine 3,3'-dithiodialanine Cys2 Cystine ((Cys)2) DISULFID DISULFID Interchain L-cystine XLNK-SCys-SCys beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide beta,beta'-dithiodialanine bis(alpha-aminopropionic acid)-beta-disulfide bis(beta-amino-beta-carboxyethyl)disulfide dicysteine PSI-MOD 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid MOD:00034 Cross-link 2; for formation of a disulfide bond between a peptide cysteine and a free cysteine, see MOD:00765. L-cystine (cross-link) MOD:00034 A protein modification that effectively cross-links two L-cysteine residues to form L-cystine. ChEBI:16283 DeltaMass:0 PubMed:1988019 PubMed:2001356 PubMed:2076469 PubMed:3083866 PubMed:366603 PubMed:7918467 PubMed:8344916 RESID:AA0025#CYS2 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 6 H 8 N 2 O 2 S 2 MassAvg: 204.26 MassMono: 204.002720 Origin: C, C Source: natural TermSpec: none (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) 3,3'-dithiobis(2-aminopropanoic acid) 3,3'-dithiobisalanine 3,3'-dithiodialanine Cys2 Cystine ((Cys)2) DISULFID DISULFID Interchain L-cystine XLNK-SCys-SCys beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide beta,beta'-dithiodialanine bis(alpha-aminopropionic acid)-beta-disulfide bis(beta-amino-beta-carboxyethyl)disulfide dicysteine 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0369 (2S,3R)-2,4-diamino-3-hydroxy-4-oxobutanoic acid (2S,3R)-2-amino-3-hydroxy-4-butanediamic acid (2S,3R)-3-hydroxyasparagine (3R)3HyAsn 2-azanyl-3-hydroxy-4-butanediamic acid L-erythro-beta-hydroxyasparagine MOD_RES (3R)-3-hydroxyasparagine erythro-beta-hydroxylated L-asparagine PSI-MOD MOD:00035 (2S,3R)-3-hydroxyasparagine MOD:00035 A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine. ChEBI:141853 PubMed:11823643 PubMed:2820791 RESID:AA0026 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 4 H 6 N 2 O 3 MassAvg: 130.10 MassMono: 130.037842 Origin: N Source: natural TermSpec: none (2S,3R)-2,4-diamino-3-hydroxy-4-oxobutanoic acid (2S,3R)-2-amino-3-hydroxy-4-butanediamic acid (2S,3R)-3-hydroxyasparagine (3R)3HyAsn 2-azanyl-3-hydroxy-4-butanediamic acid L-erythro-beta-hydroxyasparagine MOD_RES (3R)-3-hydroxyasparagine erythro-beta-hydroxylated L-asparagine A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0371 (2S,3R)-2-amino-3-hydroxybutanedioic acid (2S,3R)-3-hydroxyaspartic acid (3R)3HyAsp 2-amino-3-hydroxysuccinic acid 2-azanyl-3-hydroxybutanedioic acid 3-hydroxyaspartic acid L-erythro-beta-hydroxyaspartic acid MOD_RES (3R)-3-hydroxyaspartate erythro-beta-hydroxylated L-aspartic acid hydroxylationd PSI-MOD Oxidation MOD:00036 (2S,3R)-3-hydroxyaspartic acid MOD:00036 A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid. ChEBI:141848 OMSSA:59 PubMed:6572939 PubMed:6871167 PubMed:8355279 RESID:AA0027 Unimod:35#D DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 4 H 5 N 1 O 4 MassAvg: 131.09 MassMono: 131.021858 Origin: D Source: natural TermSpec: none Unimod: Unimod:35 (2S,3R)-2-amino-3-hydroxybutanedioic acid (2S,3R)-3-hydroxyaspartic acid (3R)3HyAsp 2-amino-3-hydroxysuccinic acid 2-azanyl-3-hydroxybutanedioic acid 3-hydroxyaspartic acid L-erythro-beta-hydroxyaspartic acid MOD_RES (3R)-3-hydroxyaspartate erythro-beta-hydroxylated L-aspartic acid hydroxylationd Oxidation A protein modification that effectively converts an L-lysine residue to one of the diastereomeric 5-hydroxy-L-lysine residues. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0044 5-hydroxylated L-lysine 5HyLys PSI-MOD MOD:00037 5-hydroxy-L-lysine MOD:00037 A protein modification that effectively converts an L-lysine residue to one of the diastereomeric 5-hydroxy-L-lysine residues. ChEBI:60175 PubMed:18688235 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 12 N 2 O 2 MassAvg: 144.17 MassMono: 144.089878 Origin: K Source: natural TermSpec: none 5-hydroxylated L-lysine 5HyLys A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0030 (2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid 3-hydroxy-L-proline 3-hydroxylated L-proline 3-trans-hydroxy-L-proline 3HyPro L-threo-3-hydroxyproline MOD_RES 3-hydroxyproline beta-hydroxypyrrolidine-alpha-carboxylic acid PSI-MOD MOD:00038 3-hydroxy-L-proline MOD:00038 A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline. ChEBI:16889 PubMed:2400108 PubMed:3734192 PubMed:4343807 RESID:AA0029 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 5 H 7 N 1 O 2 MassAvg: 113.12 MassMono: 113.047678 Origin: P Source: natural TermSpec: none (2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid 3-hydroxy-L-proline 3-hydroxylated L-proline 3-trans-hydroxy-L-proline 3HyPro L-threo-3-hydroxyproline MOD_RES 3-hydroxyproline beta-hydroxypyrrolidine-alpha-carboxylic acid A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0043 (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid 4-hydroxy-L-proline 4-hydroxylated L-proline 4-hydroxyproline 4-trans-hydroxy-L-proline 4HyPro L-threo-4-hydroxyproline MOD_RES 4-hydroxyproline gamma-hydroxypyrrolidine-alpha-carboxylic acid PSI-MOD MOD:00039 4-hydroxy-L-proline MOD:00039 A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline ChEBI:18095 PubMed:11292863 PubMed:2400108 PubMed:3734192 RESID:AA0030 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 5 H 7 N 1 O 2 MassAvg: 113.12 MassMono: 113.047678 Origin: P Source: natural TermSpec: none (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid 4-hydroxy-L-proline 4-hydroxylated L-proline 4-hydroxyproline 4-trans-hydroxy-L-proline 4HyPro L-threo-4-hydroxyproline MOD_RES 4-hydroxyproline gamma-hydroxypyrrolidine-alpha-carboxylic acid A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0261 (2S)-5-oxo-2-pyrrolidinecarboxylic acid 2-oxopyrrolidine-5-carboxylic acid 2-pyrrolidone-5-carboxylic acid 5-oxoproline 5-oxopyrrolidine-2-carboxylic acid 5-pyrrolidone-2-carboxylic acid MOD_RES Pyrrolidone carboxylic acid N-pyrrolidone carboxyl (N terminus) PCA PyrGlu(Gln) Pyroglutamic Acid formed from Gln Pyroglutamyl ntermpeppyroq pyroglutamic acid PSI-MOD Gln->pyro-Glu Pyro-glu from Q MOD:00040 DeltaMass gives a formula C 5 H 5 N 1 O 2 with mass 111.1 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid. ChEBI:30652 DeltaMass:123 OMSSA:110 PubMed:10214721 PubMed:1836357 PubMed:26343 PubMed:3473473 RESID:AA0031#GLN Unimod:28#Q DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 5 H 6 N 1 O 2 MassAvg: 112.11 MassMono: 112.039853 Origin: Q Source: natural TermSpec: N-term Unimod: Unimod:28 (2S)-5-oxo-2-pyrrolidinecarboxylic acid 2-oxopyrrolidine-5-carboxylic acid 2-pyrrolidone-5-carboxylic acid 5-oxoproline 5-oxopyrrolidine-2-carboxylic acid 5-pyrrolidone-2-carboxylic acid MOD_RES Pyrrolidone carboxylic acid N-pyrrolidone carboxyl (N terminus) PCA PyrGlu(Gln) Pyroglutamic Acid formed from Gln Pyroglutamyl ntermpeppyroq pyroglutamic acid Gln->pyro-Glu Pyro-glu from Q A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0039 (3S)-3-aminopropane-1,1,3-tricarboxylic acid (3S)-3-azanylpropane-1,1,3-tricarboxylic acid 3-amino-1,1,3-propanetricarboxylic acid 3-azanylpropane-1,1,3-tricarboxylic acid 4-carboxyglutamic acid 4CbxGlu Carboxy Glutamyl L-gamma-carboxyglutamic acid MOD_RES 4-carboxyglutamate gamma-carboxylated L-glutamic acid gammacarboxyle PSI-MOD 1-carboxyglutamic acid Carboxy Carboxylation MOD:00041 DeltaMass has an incorrect formula C 6 H 7 N 5 O 1 (N and O reversed) with mass 173. L-gamma-carboxyglutamic acid MOD:00041 A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid. DeltaMass:217 OMSSA:48 PubMed:10517147 PubMed:1807167 PubMed:3263814 PubMed:4528109 PubMed:7457858 PubMed:8135347 PubMed:8868490 PubMed:9188685 RESID:AA0032 Unimod:299#E DiffAvg: 44.01 DiffFormula: C 1 H 0 N 0 O 2 DiffMono: 43.989829 Formula: C 6 H 7 N 1 O 5 MassAvg: 173.12 MassMono: 173.032422 Origin: E Source: natural TermSpec: none Unimod: Unimod:299 (3S)-3-aminopropane-1,1,3-tricarboxylic acid (3S)-3-azanylpropane-1,1,3-tricarboxylic acid 3-amino-1,1,3-propanetricarboxylic acid 3-azanylpropane-1,1,3-tricarboxylic acid 4-carboxyglutamic acid 4CbxGlu Carboxy Glutamyl L-gamma-carboxyglutamic acid MOD_RES 4-carboxyglutamate gamma-carboxylated L-glutamic acid gammacarboxyle 1-carboxyglutamic acid Carboxy Carboxy Carboxylation A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0038 (2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid 2-aminobutanedioic 4-phosphoric anhydride 2-azanyl-4-oxo-4-(phosphonooxy)butanoic acid 4-oxo-O-phosphono-L-homoserine 4-phosphoaspartic acid 4-phosphorylated L-aspartatic acid ACT_SITE 4-aspartylphosphate intermediate L-aspartic 4-phosphoric anhydride MOD_RES 4-aspartylphosphate PAsp beta-aspartyl phosphate PSI-MOD Phospho Phosphorylation MOD:00042 L-aspartic 4-phosphoric anhydride MOD:00042 A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride. ChEBI:15836 PubMed:4357737 RESID:AA0033 Unimod:21#D DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 4 H 6 N 1 O 6 P 1 MassAvg: 195.07 MassMono: 194.993274 Origin: D Source: natural TermSpec: none Unimod: Unimod:21 (2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid 2-aminobutanedioic 4-phosphoric anhydride 2-azanyl-4-oxo-4-(phosphonooxy)butanoic acid 4-oxo-O-phosphono-L-homoserine 4-phosphoaspartic acid 4-phosphorylated L-aspartatic acid ACT_SITE 4-aspartylphosphate intermediate L-aspartic 4-phosphoric anhydride MOD_RES 4-aspartylphosphate PAsp beta-aspartyl phosphate Phospho Phosphorylation A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0251 (2R)-2-amino-3-(phosphonosulfanyl)propanoic acid 2-azanyl-3-(phosphonosulfanyl)propanoic acid ACT_SITE Phosphocysteine intermediate MOD_RES Phosphocysteine PCys S-phospho-L-cysteine S-phosphonocysteine S-phosphorylated L-cysteine S3-phosphocysteine cysteine phosphate thioester PSI-MOD Phospho Phosphorylation MOD:00043 S-phospho-L-cysteine MOD:00043 A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine. PubMed:3142516 PubMed:7961745 PubMed:8128219 RESID:AA0034 Unimod:21#C DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 S 0 DiffMono: 79.966331 Formula: C 3 H 6 N 1 O 4 P 1 S 1 MassAvg: 183.12 MassMono: 182.975515 Origin: C Source: natural TermSpec: none Unimod: Unimod:21 (2R)-2-amino-3-(phosphonosulfanyl)propanoic acid 2-azanyl-3-(phosphonosulfanyl)propanoic acid ACT_SITE Phosphocysteine intermediate MOD_RES Phosphocysteine PCys S-phospho-L-cysteine S-phosphonocysteine S-phosphorylated L-cysteine S3-phosphocysteine cysteine phosphate thioester Phospho Phosphorylation A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0325 (2S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid 1'-phospho-L-histidine 2-azanyl-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid ACT_SITE Tele-phosphohistidine intermediate MOD_RES Tele-phosphohistidine N(tau)-phosphohistidine N1-phosphonohistidine NE2-phosphonohistidine NtPHis Ntau-phosphorylated L-histidine histidine-N(epsilon)-phosphate histidine-N1'-phosphate tele-phosphohistidine PSI-MOD Phospho Phosphorylation histidine-3-phosphate MOD:00044 1'-phospho-L-histidine MOD:00044 A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine). PubMed:11038361 PubMed:5642389 PubMed:6692818 RESID:AA0035 DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 6 H 8 N 3 O 4 P 1 MassAvg: 217.12 MassMono: 217.025242 Origin: H Source: natural TermSpec: none (2S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid 1'-phospho-L-histidine 2-azanyl-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid ACT_SITE Tele-phosphohistidine intermediate MOD_RES Tele-phosphohistidine N(tau)-phosphohistidine N1-phosphonohistidine NE2-phosphonohistidine NtPHis Ntau-phosphorylated L-histidine histidine-N(epsilon)-phosphate histidine-N1'-phosphate tele-phosphohistidine Phospho Phosphorylation histidine-3-phosphate A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0260 (2S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid 2-azanyl-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid 3'-phospho-L-histidine ACT_SITE Pros-phosphohistidine intermediate MOD_RES Pros-phosphohistidine N(pi)-phosphohistidine N3-phosphonohistidine ND1-phosphonohistidine NpPHis Npi-phosphorylated L-histidine histidine-N(delta)-phosphate histidine-N3'-phosphate pros-phosphohistidine PSI-MOD Phospho Phosphorylation histidine-1-phosphate MOD:00045 3'-phospho-L-histidine MOD:00045 A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine). PubMed:1549615 PubMed:5642389 PubMed:6692818 PubMed:7669763 PubMed:7803390 RESID:AA0036 DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 6 H 8 N 3 O 4 P 1 MassAvg: 217.12 MassMono: 217.025242 Origin: H Source: natural TermSpec: none (2S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid 2-azanyl-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid 3'-phospho-L-histidine ACT_SITE Pros-phosphohistidine intermediate MOD_RES Pros-phosphohistidine N(pi)-phosphohistidine N3-phosphonohistidine ND1-phosphonohistidine NpPHis Npi-phosphorylated L-histidine histidine-N(delta)-phosphate histidine-N3'-phosphate pros-phosphohistidine Phospho Phosphorylation histidine-1-phosphate A protein modification that effectively converts an L-serine residue to O-phospho-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0253 (2S)-2-amino-3-(phosphonooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)propanoic acid ACT_SITE Phosphoserine intermediate MOD_RES Phosphoserine O-phospho-L-serine O-phosphonoserine O-phosphorylated L-serine O3-phosphoserine OPSer Phospho Seryl phosphorylations serine phosphate ester PSI-MOD Phospho Phosphorylation MOD:00046 O-phospho-L-serine MOD:00046 A protein modification that effectively converts an L-serine residue to O-phospho-L-serine. ChEBI:15811 DeltaMass:0 OMSSA:6 PubMed:12923550 PubMed:4065410 PubMed:8061611 RESID:AA0037 Unimod:21#S DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 3 H 6 N 1 O 5 P 1 MassAvg: 167.06 MassMono: 166.998359 Origin: S Source: natural TermSpec: none Unimod: Unimod:21 (2S)-2-amino-3-(phosphonooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)propanoic acid ACT_SITE Phosphoserine intermediate MOD_RES Phosphoserine O-phospho-L-serine O-phosphonoserine O-phosphorylated L-serine O3-phosphoserine OPSer Phospho Seryl phosphorylations serine phosphate ester Phospho Phosphorylation A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0254 (2S,3R)-2-amino-3-(phosphonooxy)butanoic acid 2-amino-3-hydroxybutanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)butanoic acid MOD_RES Phosphothreonine O-phospho-L-threonine O-phosphorylated L-threonine O3-phosphothreonine OPThr Phospho Threonyl phosphorylationt threonine phosphate ester PSI-MOD Phospho Phosphorylation MOD:00047 O-phospho-L-threonine MOD:00047 A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine. ChEBI:21967 DeltaMass:0 OMSSA:7 PubMed:12923550 PubMed:7678926 RESID:AA0038 Unimod:21#T DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 4 H 8 N 1 O 5 P 1 MassAvg: 181.08 MassMono: 181.014009 Origin: T Source: natural TermSpec: none Unimod: Unimod:21 (2S,3R)-2-amino-3-(phosphonooxy)butanoic acid 2-amino-3-hydroxybutanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)butanoic acid MOD_RES Phosphothreonine O-phospho-L-threonine O-phosphorylated L-threonine O3-phosphothreonine OPThr Phospho Threonyl phosphorylationt threonine phosphate ester Phospho Phosphorylation A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0255 (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine O4-phosphotyrosine OPTyr Phospho Tyrosinyl phosphorylationy tyrosine phosphate PSI-MOD Phospho Phosphorylation MOD:00048 O4'-phospho-L-tyrosine MOD:00048 A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine. DeltaMass:0 OMSSA:8 PubMed:10226369 PubMed:1725475 RESID:AA0039 Unimod:21#Y DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 9 H 10 N 1 O 5 P 1 MassAvg: 243.15 MassMono: 243.029659 Origin: Y Source: natural TermSpec: none Unimod: Unimod:21 (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine O4-phosphotyrosine OPTyr Phospho Tyrosinyl phosphorylationy tyrosine phosphate Phospho Phosphorylation A protein modification that effectively converts an L-histidine residue to diphthamide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0118 (2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium (3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium 1-azanyl-4-(4-[2-azanyl-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-azanium 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine 2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole 2-[3-carboxamido-3-(trimethylammonio)propyl]histidine 2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid 2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide Diphth MOD_RES Diphthamide alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium diphthamide diphthamide (from histidine) PSI-MOD Diphthamide MOD:00049 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine MOD:00049 A protein modification that effectively converts an L-histidine residue to diphthamide. ChEBI:16692 DeltaMass:122 PubMed:15316019 PubMed:7430147 RESID:AA0040 Unimod:375#H DiffAvg: 143.21 DiffFormula: C 7 H 15 N 2 O 1 DiffMono: 143.117890 FormalCharge: 1+ Formula: C 13 H 22 N 5 O 2 MassAvg: 280.35 MassMono: 280.176801 Origin: H Source: natural TermSpec: none Unimod: Unimod:375 (2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium (3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium 1-azanyl-4-(4-[2-azanyl-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-azanium 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine 2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole 2-[3-carboxamido-3-(trimethylammonio)propyl]histidine 2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid 2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide Diphth MOD_RES Diphthamide alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium diphthamide diphthamide (from histidine) Diphthamide Diphthamide A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0199 (2S)-2-(acetamido)propanoic acid 2-(acetylamino)propanoic acid 2-(acetylazanyl)propanoic acid AcAla MOD_RES N-acetylalanine N-acetyl-L-alanine N-acetylated L-alanine acetylalanine PSI-MOD MOD:00050 N-acetyl-L-alanine MOD:00050 A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine. PubMed:363452 PubMed:4700463 RESID:AA0041 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 5 H 8 N 1 O 2 MassAvg: 114.12 MassMono: 114.055504 Origin: A Source: natural TermSpec: N-term (2S)-2-(acetamido)propanoic acid 2-(acetylamino)propanoic acid 2-(acetylazanyl)propanoic acid AcAla MOD_RES N-acetylalanine N-acetyl-L-alanine N-acetylated L-alanine acetylalanine A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0200 (2S)-2-(acetamido)butanedioic acid 2-(acetylamino)butanedioic acid 2-(acetylazanyl)butanedioic acid AcAsp MOD_RES N-acetylaspartate N-acetyl-L-aspartic acid N-acetylated L-aspartic acid acetylaspartic acid PSI-MOD MOD:00051 N-acetyl-L-aspartic acid MOD:00051 A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid. ChEBI:21547 PubMed:1560020 PubMed:2395459 RESID:AA0042 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 6 H 8 N 1 O 4 MassAvg: 158.13 MassMono: 158.045333 Origin: D Source: natural TermSpec: N-term (2S)-2-(acetamido)butanedioic acid 2-(acetylamino)butanedioic acid 2-(acetylazanyl)butanedioic acid AcAsp MOD_RES N-acetylaspartate N-acetyl-L-aspartic acid N-acetylated L-aspartic acid acetylaspartic acid A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0201 (2R)-2-acetamido-3-sulfanylpropanoic acid 2-acetylamino-3-mercaptopropanoic acid 2-acetylamino-3-sulfanylpropanoic acid 2-acetylazanyl-3-sulfanylpropanoic acid MOD_RES N-acetylcysteine N-acetyl-L-cysteine N-acetylated cysteine N-acetylcysteine NAcCys PSI-MOD Acetyl MOD:00052 incidental to RESID:AA0223 N-acetyl-L-cysteine MOD:00052 A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine. ChEBI:28939 PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:1500421 PubMed:15350136 PubMed:6725286 RESID:AA0043 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 S 0 DiffMono: 42.010565 Formula: C 5 H 8 N 1 O 2 S 1 MassAvg: 146.18 MassMono: 146.027574 Origin: C Source: natural TermSpec: N-term (2R)-2-acetamido-3-sulfanylpropanoic acid 2-acetylamino-3-mercaptopropanoic acid 2-acetylamino-3-sulfanylpropanoic acid 2-acetylazanyl-3-sulfanylpropanoic acid MOD_RES N-acetylcysteine N-acetyl-L-cysteine N-acetylated cysteine N-acetylcysteine NAcCys Acetyl A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0202 (2S)-2-(acetamido)pentanedioic acid 2-(acetylamino)pentanedioic acid 2-(acetylazanyl)pentanedioic acid AcGlu MOD_RES N-acetylglutamate N-acetyl-L-glutamic acid N-acetylated L-glutamic acid acetylglutamic acid PSI-MOD MOD:00053 N-acetyl-L-glutamic acid MOD:00053 A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid. ChEBI:17533 PubMed:6725286 RESID:AA0044 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 7 H 10 N 1 O 4 MassAvg: 172.16 MassMono: 172.060983 Origin: E Source: natural TermSpec: N-term (2S)-2-(acetamido)pentanedioic acid 2-(acetylamino)pentanedioic acid 2-(acetylazanyl)pentanedioic acid AcGlu MOD_RES N-acetylglutamate N-acetyl-L-glutamic acid N-acetylated L-glutamic acid acetylglutamic acid A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-acetamido-5-pentanediamic acid 2-acetylamino-5-amino-5-oxopentanoic acid 2-acetylamino-5-pentanediamic acid 2-acetylazanyl-5-azanyl-5-oxopentanoic acid AcGln N-acetyl-L-glutamine N-acetylated L-glutamine acetylglutamine PSI-MOD MOD:00054 This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. N-acetyl-L-glutamine MOD:00054 A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine. RESID:AA0045 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 7 H 11 N 2 O 3 MassAvg: 171.18 MassMono: 171.076967 Origin: Q Source: artifact TermSpec: N-term (2S)-2-acetamido-5-pentanediamic acid 2-acetylamino-5-amino-5-oxopentanoic acid 2-acetylamino-5-pentanediamic acid 2-acetylazanyl-5-azanyl-5-oxopentanoic acid AcGln N-acetyl-L-glutamine N-acetylated L-glutamine acetylglutamine A protein modification that effectively converts a glycine residue to N-acetylglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0203 (acetylamino)acetic acid (acetylazanyl)ethanoic acid 2-(acetamido)ethanoic acid 2-(acetylamino)ethanoic acid AcGly MOD_RES N-acetylglycine N-acetylated glycine N-acetylglycine aceturic acid PSI-MOD MOD:00055 N-acetylglycine MOD:00055 A protein modification that effectively converts a glycine residue to N-acetylglycine. PubMed:272676 PubMed:5545094 PubMed:6754709 RESID:AA0046 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 4 H 6 N 1 O 2 MassAvg: 100.10 MassMono: 100.039853 Origin: G Source: natural TermSpec: N-term (acetylamino)acetic acid (acetylazanyl)ethanoic acid 2-(acetamido)ethanoic acid 2-(acetylamino)ethanoic acid AcGly MOD_RES N-acetylglycine N-acetylated glycine N-acetylglycine aceturic acid A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0204 (2S,3S)-2-acetamido-3-methylpentanoic acid 2-acetylamino-3-methylpentanoic acid 2-acetylazanyl-3-methylpentanoic acid AcIle N-acetyl-L-isoleucine N-acetylated L-isoleucine acetylisoleucine PSI-MOD MOD:00056 This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. N-acetyl-L-isoleucine MOD:00056 A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine. PubMed:8034631 RESID:AA0047 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 8 H 14 N 1 O 2 MassAvg: 156.20 MassMono: 156.102454 Origin: I Source: artifact TermSpec: N-term (2S,3S)-2-acetamido-3-methylpentanoic acid 2-acetylamino-3-methylpentanoic acid 2-acetylazanyl-3-methylpentanoic acid AcIle N-acetyl-L-isoleucine N-acetylated L-isoleucine acetylisoleucine A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-acetamido-6-aminohexanoic acid 2-acetylamino-6-aminohexanoic acid 2-acetylazanyl-6-azanylhexanoic acid N2-acetyl-L-lysine N2-acetylated L-lysine N2-acetyllysine N2AcLys PSI-MOD Acetyl MOD:00057 This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. N2-acetyl-L-lysine MOD:00057 A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 RESID:AA0048 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 8 H 15 N 2 O 2 MassAvg: 171.22 MassMono: 171.113353 Origin: K Source: artifact TermSpec: N-term (2S)-2-acetamido-6-aminohexanoic acid 2-acetylamino-6-aminohexanoic acid 2-acetylazanyl-6-azanylhexanoic acid N2-acetyl-L-lysine N2-acetylated L-lysine N2-acetyllysine N2AcLys Acetyl A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0205 (2S)-2-acetamido-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylthio)butanoic acid 2-acetylazanyl-4-(methylsulfanyl)butanoic acid AcMet MOD_RES N-acetylmethionine N-acetyl-L-methionine N-acetylated L-methionine acetylmethionine methionamine PSI-MOD MOD:00058 N-acetyl-L-methionine MOD:00058 A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine. PubMed:7944406 RESID:AA0049 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 S 0 DiffMono: 42.010565 Formula: C 7 H 12 N 1 O 2 S 1 MassAvg: 174.24 MassMono: 174.058875 Origin: M Source: natural TermSpec: N-term (2S)-2-acetamido-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylthio)butanoic acid 2-acetylazanyl-4-(methylsulfanyl)butanoic acid AcMet MOD_RES N-acetylmethionine N-acetyl-L-methionine N-acetylated L-methionine acetylmethionine methionamine A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0206 (2S)-1-acetyl-2-pyrrolidinecarboxylic acid 1-acetylproline MOD_RES N-acetylproline N-acetyl-L-proline N-acetylated L-proline N-acetylproline NAcPro acetylproline PSI-MOD MOD:00059 N-acetyl-L-proline MOD:00059 A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline. PubMed:2928307 RESID:AA0050 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 7 H 10 N 1 O 2 MassAvg: 140.16 MassMono: 140.071154 Origin: P Source: natural TermSpec: N-term (2S)-1-acetyl-2-pyrrolidinecarboxylic acid 1-acetylproline MOD_RES N-acetylproline N-acetyl-L-proline N-acetylated L-proline N-acetylproline NAcPro acetylproline A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0207 (2S)-2-acetamido-3-hydroxypropanoic acid 2-acetylamino-3-hydroxypropanoic acid 2-acetylazanyl-3-hydroxypropanoic acid MOD_RES N-acetylserine N-acetyl-L-serine N-acetylated L-serine N-acetylserine NAcSer PSI-MOD Acetyl MOD:00060 N-acetyl-L-serine MOD:00060 A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 PubMed:1880797 PubMed:2106685 PubMed:6997045 RESID:AA0051 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 5 H 8 N 1 O 3 MassAvg: 130.12 MassMono: 130.050418 Origin: S Source: natural TermSpec: N-term (2S)-2-acetamido-3-hydroxypropanoic acid 2-acetylamino-3-hydroxypropanoic acid 2-acetylazanyl-3-hydroxypropanoic acid MOD_RES N-acetylserine N-acetyl-L-serine N-acetylated L-serine N-acetylserine NAcSer Acetyl A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0208 (2S,3R)-2-acetamido-3-hydroxybutanoic acid 2-acetylamino-3-hydroxybutanoic acid 2-acetylazanyl-3-hydroxybutanoic acid MOD_RES N-acetylthreonine N-acetyl-L-threonine N-acetylated L-threonine N-acetylthreonine N-methylcarbonylthreonine NAcThr PSI-MOD Acetyl Acetylation MOD:00061 N-acetyl-L-threonine MOD:00061 A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 PubMed:2106685 PubMed:6997045 RESID:AA0052 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 6 H 10 N 1 O 3 MassAvg: 144.15 MassMono: 144.066068 Origin: T Source: natural TermSpec: N-term (2S,3R)-2-acetamido-3-hydroxybutanoic acid 2-acetylamino-3-hydroxybutanoic acid 2-acetylazanyl-3-hydroxybutanoic acid MOD_RES N-acetylthreonine N-acetyl-L-threonine N-acetylated L-threonine N-acetylthreonine N-methylcarbonylthreonine NAcThr Acetyl Acetylation A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0209 (2S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid 2-acetylamino-3-(4-hydoxyphenyl)propanoic acid 2-acetylazanyl-3-(4-hydoxyphenyl)propanoic acid AcTyr MOD_RES N-acetyltyrosine N-acetyl-L-tyrosine N-acetylated L-tyrosine N-acetyltyrosine PSI-MOD Acetyl MOD:00062 N-acetyl-L-tyrosine MOD:00062 A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 PubMed:2506074 PubMed:475783 RESID:AA0053 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 11 H 12 N 1 O 3 MassAvg: 206.22 MassMono: 206.081718 Origin: Y Source: natural TermSpec: N-term (2S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid 2-acetylamino-3-(4-hydoxyphenyl)propanoic acid 2-acetylazanyl-3-(4-hydoxyphenyl)propanoic acid AcTyr MOD_RES N-acetyltyrosine N-acetyl-L-tyrosine N-acetylated L-tyrosine N-acetyltyrosine Acetyl A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0210 (2S)-2-acetamido-3-methylbutanoic acid 2-acetylamino-3-methylbutanoic acid 2-acetylazanyl-3-methylbutanoic acid AcVal MOD_RES N-acetylvaline N-acetyl-L-valine N-acetylated L-valine N-acetylvaline PSI-MOD MOD:00063 N-acetyl-L-valine MOD:00063 A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine. PubMed:1735421 RESID:AA0054 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 7 H 12 N 1 O 2 MassAvg: 142.18 MassMono: 142.086804 Origin: V Source: natural TermSpec: N-term (2S)-2-acetamido-3-methylbutanoic acid 2-acetylamino-3-methylbutanoic acid 2-acetylazanyl-3-methylbutanoic acid AcVal MOD_RES N-acetylvaline N-acetyl-L-valine N-acetylated L-valine N-acetylvaline A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0190 (2S)-6-acetamido-2-aminohexanoic acid 6-acetylamino-2-aminohexanoic acid 6-acetylazanyl-2-aminohexanoic acid MOD_RES N6-acetyllysine N(zeta)-acetyllysine N6-acetyl-L-lysine N6-acetylated L-lysine N6AcLys acetylk epsilon-acetyllysine PSI-MOD Acetyl Acetylation MOD:00064 N6-acetyl-L-lysine MOD:00064 A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine. ChEBI:17752 DeltaMass:214 OMSSA:24 PubMed:11369851 PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 PubMed:1680872 PubMed:670159 RESID:AA0055 Unimod:1#K DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 8 H 14 N 2 O 2 MassAvg: 170.21 MassMono: 170.105528 Origin: K Source: natural TermSpec: none Unimod: Unimod:1 (2S)-6-acetamido-2-aminohexanoic acid 6-acetylamino-2-aminohexanoic acid 6-acetylazanyl-2-aminohexanoic acid MOD_RES N6-acetyllysine N(zeta)-acetyllysine N6-acetyl-L-lysine N6-acetylated L-lysine N6AcLys acetylk epsilon-acetyllysine Acetyl Acetylation A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2R)-3-acetylsulfanyl-2-aminopropanoic acid 2-amino-3-(acetylthio)propanoic acid 2-azanyl-3-(acetylsulfanyl)propanoic acid ACT_SITE S-acetylcysteine intermediate S-acetyl-L-cysteine S-acetylcysteine SAcCys cysteine acetate thioester PSI-MOD Acetyl Acetylation MOD:00065 S-acetyl-L-cysteine MOD:00065 A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:1310545 PubMed:14730666 PubMed:15350136 RESID:AA0056 Unimod:1#C DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 S 0 DiffMono: 42.010565 Formula: C 5 H 7 N 1 O 2 S 1 MassAvg: 145.18 MassMono: 145.019749 Origin: C Source: natural TermSpec: none Unimod: Unimod:1 (2R)-3-acetylsulfanyl-2-aminopropanoic acid 2-amino-3-(acetylthio)propanoic acid 2-azanyl-3-(acetylsulfanyl)propanoic acid ACT_SITE S-acetylcysteine intermediate S-acetyl-L-cysteine S-acetylcysteine SAcCys cysteine acetate thioester Acetyl Acetylation A protein modification that effectively converts a glycine residue to N-formylglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0211 (formylamino)acetic acid (formylamino)ethanoic acid (formylazanyl)ethanoic acid 2-formamidoacetic acid 2-formamidoethanoic acid MOD_RES N-formylglycine N(alpha)-formylglycine N-formylated glycine N-formylglycine NFoGly PSI-MOD MOD:00066 N-formylglycine MOD:00066 A protein modification that effectively converts a glycine residue to N-formylglycine. PubMed:5139483 RESID:AA0057 DiffAvg: 28.01 DiffFormula: C 1 H 0 N 0 O 1 DiffMono: 27.994915 Formula: C 3 H 4 N 1 O 2 MassAvg: 86.07 MassMono: 86.024203 Origin: G Source: natural TermSpec: N-term (formylamino)acetic acid (formylamino)ethanoic acid (formylazanyl)ethanoic acid 2-formamidoacetic acid 2-formamidoethanoic acid MOD_RES N-formylglycine N(alpha)-formylglycine N-formylated glycine N-formylglycine NFoGly A protein modification that effectively converts a glycine residue to N-D-glucuronoylglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0331 2-(glucuronoylamino)ethanoic acid MOD_RES N-D-glucuronoyl glycine N-D-glucuronoyl-glycine N-D-glucuronyl-glycine NGlcAGly ntermpepglucuronylg PSI-MOD Glucuronyl MOD:00067 N-D-glucuronoylglycine MOD:00067 A protein modification that effectively converts a glycine residue to N-D-glucuronoylglycine. OMSSA:50 PubMed:10858503 PubMed:12716131 PubMed:6493057 PubMed:7398618 RESID:AA0058 DiffAvg: 176.12 DiffFormula: C 6 H 8 N 0 O 6 DiffMono: 176.032088 Formula: C 8 H 12 N 1 O 7 MassAvg: 234.18 MassMono: 234.061377 Origin: G Source: natural TermSpec: N-term 2-(glucuronoylamino)ethanoic acid MOD_RES N-D-glucuronoyl glycine N-D-glucuronoyl-glycine N-D-glucuronyl-glycine NGlcAGly ntermpepglucuronylg Glucuronyl A protein modification that effectively converts a glycine residue to N-myristoylglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0221 (tetradecanoylamino)ethanoic acid LIPID N-myristoyl glycine N-(1-oxotetradecyl)glycine N-(C14:0 aliphatic acyl)glycine N-myristoyl-glycine N-myristoylated glycine N-myristylglycine N-tetradecanoylglycine NMyrGly ntermpepmyristoylationg PSI-MOD Myristoyl Myristoylation MOD:00068 N-myristoylglycine MOD:00068 A protein modification that effectively converts a glycine residue to N-myristoylglycine. OMSSA:80 PubMed:11955007 PubMed:11955008 PubMed:1326520 PubMed:1386601 PubMed:6436247 PubMed:7543369 RESID:AA0059 Unimod:45#G DiffAvg: 210.36 DiffFormula: C 14 H 26 N 0 O 1 DiffMono: 210.198365 Formula: C 16 H 30 N 1 O 2 MassAvg: 268.42 MassMono: 268.227654 Origin: G Source: natural TermSpec: N-term Unimod: Unimod:45 (tetradecanoylamino)ethanoic acid LIPID N-myristoyl glycine N-(1-oxotetradecyl)glycine N-(C14:0 aliphatic acyl)glycine N-myristoyl-glycine N-myristoylated glycine N-myristylglycine N-tetradecanoylglycine NMyrGly ntermpepmyristoylationg Myristoyl Myristoylation A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0222 (2R)-2-hexadecanoylamino-3-sulfanylpropanoic acid 2-hexadecanamido-3-sulfanylpropanoic acid 2-hexadecanoylamino-3-mercaptopropanoic acid LIPID N-palmitoyl cysteine N-(1-oxahexadecyl)-L-cysteine N-hexadecanoylated L-cysteine N-palmitoyl-L-cysteine N-palmitoylated L-cysteine NPamCys PSI-MOD Palmitoyl Palmitoylation MOD:00069 incidental to RESID:AA0107 incidental to RESID:AA0309 N-palmitoyl-L-cysteine MOD:00069 A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine. PubMed:10896212 PubMed:4575979 PubMed:9056182 PubMed:9593755 RESID:AA0060 DiffAvg: 238.41 DiffFormula: C 16 H 30 N 0 O 1 S 0 DiffMono: 238.229666 Formula: C 19 H 36 N 1 O 2 S 1 MassAvg: 342.56 MassMono: 342.246675 Origin: C Source: natural TermSpec: N-term (2R)-2-hexadecanoylamino-3-sulfanylpropanoic acid 2-hexadecanamido-3-sulfanylpropanoic acid 2-hexadecanoylamino-3-mercaptopropanoic acid LIPID N-palmitoyl cysteine N-(1-oxahexadecyl)-L-cysteine N-hexadecanoylated L-cysteine N-palmitoyl-L-cysteine N-palmitoylated L-cysteine NPamCys Palmitoyl Palmitoylation A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0214 (2S)-2-methylaminopropanoic acid 2-methylazanylpropanoic acid MOD_RES N-methylalanine N-methyl-L-alanine N-methylalanine N-methylated L-alanine NMe1Ala PSI-MOD Methyl Methylation MOD:00070 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-alanine MOD:00070 A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine. ChEBI:17519 PubMed:323502 PubMed:337304 PubMed:7007074 RESID:AA0061 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 4 H 7 N 1 O 1 MassAvg: 85.11 MassMono: 85.052764 Origin: A Source: natural TermSpec: N-term (2S)-2-methylaminopropanoic acid 2-methylazanylpropanoic acid MOD_RES N-methylalanine N-methyl-L-alanine N-methylalanine N-methylated L-alanine NMe1Ala Methyl Methylation A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0177 (1S)-1-carboxy-N,N,N-trimethylethanaminium (1S)-1-carboxy-N,N,N-trimethylethanazanium (2S)-2-(trimethylammonio)propanoic acid MOD_RES N,N,N-trimethylalanine N,N,N-trimethyl-L-alanine N,N,N-trimethylalanine cation N,N,N-trimethylalaninium N,N,N-trimethylated L-alanine N2Me3+Ala NMe3Ala PSI-MOD Trimethyl tri-Methylation MOD:00071 N,N,N-trimethyl-L-alanine MOD:00071 A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine. PubMed:12590383 PubMed:332162 PubMed:3979397 PubMed:6778808 PubMed:7715456 RESID:AA0062 DiffAvg: 43.09 DiffFormula: C 3 H 7 N 0 O 0 DiffMono: 43.054227 FormalCharge: 1+ Formula: C 6 H 13 N 1 O 1 MassAvg: 115.18 MassMono: 115.099165 Origin: A Source: natural TermSpec: N-term (1S)-1-carboxy-N,N,N-trimethylethanaminium (1S)-1-carboxy-N,N,N-trimethylethanazanium (2S)-2-(trimethylammonio)propanoic acid MOD_RES N,N,N-trimethylalanine N,N,N-trimethyl-L-alanine N,N,N-trimethylalanine cation N,N,N-trimethylalaninium N,N,N-trimethylated L-alanine N2Me3+Ala NMe3Ala Trimethyl tri-Methylation A protein modification that effectively converts a glycine residue to N-methylglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0483 L-sarcosine MOD_RES N-methylglycine N-methylated glycine N-methylglycine NMe1Gly Sar Sarcosine Sarcosyl methylaminoacetic acid methylaminoethanoic acid PSI-MOD Methyl Methylation MOD:00072 DeltaMass also has an entry for the free amino acid. Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methylglycine MOD:00072 A protein modification that effectively converts a glycine residue to N-methylglycine. ChEBI:15611 DeltaMass:0 PubMed:1593629 RESID:AA0063 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 3 H 5 N 1 O 1 MassAvg: 71.08 MassMono: 71.037114 Origin: G Source: natural TermSpec: N-term L-sarcosine MOD_RES N-methylglycine N-methylated glycine N-methylglycine NMe1Gly Sar Sarcosine Sarcosyl methylaminoacetic acid methylaminoethanoic acid Methyl Methylation A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0217 (2S)-2-methylamino-4-(methylsulfanyl)butanoic acid 2-methylamino-4-(methylthio)butanoic acid MOD_RES N-methylmethionine Methyl Methionyl N-methyl-L-methionine N-methylated L-methionine N-methylmethionine NMe1Met PSI-MOD Methyl Methylation MOD:00073 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-methionine MOD:00073 A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine. DeltaMass:169 PubMed:323502 PubMed:3298225 RESID:AA0064 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 S 0 DiffMono: 14.015650 Formula: C 6 H 11 N 1 O 1 S 1 MassAvg: 145.22 MassMono: 145.056135 Origin: M Source: natural TermSpec: N-term (2S)-2-methylamino-4-(methylsulfanyl)butanoic acid 2-methylamino-4-(methylthio)butanoic acid MOD_RES N-methylmethionine Methyl Methionyl N-methyl-L-methionine N-methylated L-methionine N-methylmethionine NMe1Met Methyl Methylation A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0218 (2S)-2-methylamino-3-phenylpropanoic acid MOD_RES N-methylphenylalanine N-methyl-L-phenylalanine N-methylated L-phenylalanine N-methylphenylalanine NMe1Phe PSI-MOD Methyl Methylation MOD:00074 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-phenylalanine MOD:00074 A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine. PubMed:2577730 PubMed:413571 RESID:AA0065 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 10 H 11 N 1 O 1 MassAvg: 161.20 MassMono: 161.084064 Origin: F Source: natural TermSpec: N-term (2S)-2-methylamino-3-phenylpropanoic acid MOD_RES N-methylphenylalanine N-methyl-L-phenylalanine N-methylated L-phenylalanine N-methylphenylalanine NMe1Phe Methyl Methylation A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0179 (2S)-2-carboxy-1,1-dimethylpyrrolidinium 1,1-dimethyl-L-prolinium MOD_RES N,N-dimethylproline N,N-dimethyl-L-proline N,N-dimethyl-L-prolinium N,N-dimethylated L-proline NMe2Pro stachydrin PSI-MOD Delta:H(5)C(2) Dimethyl Dimethylation of proline residue MOD:00075 Unimod terminal specification corrected [JSG]. N,N-dimethyl-L-proline MOD:00075 A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline. ChEBI:21451 PubMed:12964758 PubMed:14570711 PubMed:193025 PubMed:3882426 PubMed:6254758 RESID:AA0066 Unimod:529 DiffAvg: 29.06 DiffFormula: C 2 H 5 N 0 O 0 DiffMono: 29.038577 FormalCharge: 1+ Formula: C 7 H 13 N 1 O 1 MassAvg: 127.19 MassMono: 127.099165 Origin: P Source: natural TermSpec: N-term Unimod: Unimod:529 (2S)-2-carboxy-1,1-dimethylpyrrolidinium 1,1-dimethyl-L-prolinium MOD_RES N,N-dimethylproline N,N-dimethyl-L-proline N,N-dimethyl-L-prolinium N,N-dimethylated L-proline NMe2Pro stachydrin Delta:H(5)C(2) Dimethyl Dimethylation of proline residue A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0287 (2S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid MOD_RES Omega-N-methylated arginine MOD_RES Symmetric dimethylarginine N3,N4-dimethylarginine N5-[(methylamino)(methylimino)methyl]ornithine NG,N'G-dimethylarginine NoNo'Me2Arg omega-N,omega-N'-dimethyl-L-arginine omega-N,omega-N'-dimethylated L-arginine symmetric dimethylarginine PSI-MOD Dimethyl di-Methylation MOD:00076 symmetric dimethyl-L-arginine MOD:00076 A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine. PubMed:12964758 PubMed:14570711 PubMed:15835918 PubMed:2426402 PubMed:5128665 RESID:AA0067 Unimod:36#R DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 8 H 16 N 4 O 1 MassAvg: 184.24 MassMono: 184.132411 Origin: R Source: natural TermSpec: none Unimod: Unimod:36 (2S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid MOD_RES Omega-N-methylated arginine MOD_RES Symmetric dimethylarginine N3,N4-dimethylarginine N5-[(methylamino)(methylimino)methyl]ornithine NG,N'G-dimethylarginine NoNo'Me2Arg omega-N,omega-N'-dimethyl-L-arginine omega-N,omega-N'-dimethylated L-arginine symmetric dimethylarginine Dimethyl di-Methylation A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0066 (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid MOD_RES Asymmetric dimethylarginine MOD_RES Omega-N-methylated arginine N5-[(dimethylamino)(imino)methyl]ornithine NG,NG-dimethylarginine NoNoMe2Arg asymmetric dimethylarginine omega-N,omega-N-dimethlyated L-arginine omega-N,omega-N-dimethyl-L-arginine PSI-MOD Dimethyl di-Methylation MOD:00077 asymmetric dimethyl-L-arginine MOD:00077 A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine. ChEBI:17929 PubMed:11152131 PubMed:12964758 PubMed:14570711 PubMed:15835918 PubMed:3032834 RESID:AA0068 Unimod:36#R DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 8 H 16 N 4 O 1 MassAvg: 184.24 MassMono: 184.132411 Origin: R Source: natural TermSpec: none Unimod: Unimod:36 (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid MOD_RES Asymmetric dimethylarginine MOD_RES Omega-N-methylated arginine N5-[(dimethylamino)(imino)methyl]ornithine NG,NG-dimethylarginine NoNoMe2Arg asymmetric dimethylarginine omega-N,omega-N-dimethlyated L-arginine omega-N,omega-N-dimethyl-L-arginine Dimethyl di-Methylation A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0237 (2S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid MOD_RES Omega-N-methylarginine MOD_RES Omega-N-methylated arginine NG-methylarginine NoMeArg omega-N-methyl-L-arginine omega-N-methylated L-arginine PSI-MOD Methyl Methylation MOD:00078 omega-N-methyl-L-arginine MOD:00078 A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine. PubMed:11875433 PubMed:15835918 PubMed:2426402 PubMed:5128665 RESID:AA0069 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 14 N 4 O 1 MassAvg: 170.22 MassMono: 170.116761 Origin: R Source: natural TermSpec: none (2S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid MOD_RES Omega-N-methylarginine MOD_RES Omega-N-methylated arginine NG-methylarginine NoMeArg omega-N-methyl-L-arginine omega-N-methylated L-arginine Methyl Methylation A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0183 (2S)-2-amino-N4-methylbutanediamic acid MOD_RES N4-methylasparagine N(gamma)-methylasparagine N-methylasparagine N4-methyl-L-asparagine N4-methylated L-asparagine N4Me1Asn beta-aspartyl methylamide methyln PSI-MOD Methyl Methylation beta-methylasparagine MOD:00079 N4-methyl-L-asparagine MOD:00079 A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine. OMSSA:75 PubMed:11875433 PubMed:2356973 PubMed:3782095 RESID:AA0070 Unimod:34#N DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 5 H 8 N 2 O 2 MassAvg: 128.13 MassMono: 128.058578 Origin: N Source: natural TermSpec: none Unimod: Unimod:34 (2S)-2-amino-N4-methylbutanediamic acid MOD_RES N4-methylasparagine N(gamma)-methylasparagine N-methylasparagine N4-methyl-L-asparagine N4-methylated L-asparagine N4Me1Asn beta-aspartyl methylamide methyln Methyl Methylation beta-methylasparagine A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0185 (2S)-2-amino-5-methylamino-5-oxopentanoic acid 2-amino-N5-methylpentanediamic acid MOD_RES N5-methylglutamine N(delta)-methylglutamine N-methylglutamine N5-methyl-L-glutamine N5-methylated L-glutamine N5Me1Gln gamma-methylglutamine PSI-MOD Methyl Methylation MOD:00080 N5-methyl-L-glutamine MOD:00080 A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine. ChEBI:17592 DeltaMass:166 PubMed:11118225 PubMed:11875433 PubMed:365579 RESID:AA0071 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 6 H 10 N 2 O 2 MassAvg: 142.16 MassMono: 142.074228 Origin: Q Source: natural TermSpec: none (2S)-2-amino-5-methylamino-5-oxopentanoic acid 2-amino-N5-methylpentanediamic acid MOD_RES N5-methylglutamine N(delta)-methylglutamine N-methylglutamine N5-methyl-L-glutamine N5-methylated L-glutamine N5Me1Gln gamma-methylglutamine Methyl Methylation A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0128 (2S)-2-amino-5-methoxy-5-oxopentanoic acid (5)-methyl L-hydrogen glutamate 2-aminopentanedioic acid 5-methyl ester 5-methyl L-2-aminoglutarate 5-methyl L-glutamate 5-methyl esterified L-glutamic acid L-glutamic acid 5-methyl ester MOD_RES Glutamate methyl ester (Glu) O-methyl Glutamyl O5MeGlu glutamic acid 5-methyl ester glutamic acid gamma-methyl ester meestere methyle PSI-MOD Methyl Methylation methyl ester MOD:00081 DeltaMass gives the formula "C 6 H 9 O 1 N 3" with mass 143 (formula incorrect, N and O reversed) [JSG]. L-glutamic acid 5-methyl ester (Glu) MOD:00081 A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester. DeltaMass:167 OMSSA:17 OMSSA:70 PubMed:16888 PubMed:6300110 RESID:AA0072#GLU Unimod:34#E DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 6 H 9 N 1 O 3 MassAvg: 143.14 MassMono: 143.058243 Origin: E Source: natural TermSpec: none Unimod: Unimod:34 (2S)-2-amino-5-methoxy-5-oxopentanoic acid (5)-methyl L-hydrogen glutamate 2-aminopentanedioic acid 5-methyl ester 5-methyl L-2-aminoglutarate 5-methyl L-glutamate 5-methyl esterified L-glutamic acid L-glutamic acid 5-methyl ester MOD_RES Glutamate methyl ester (Glu) O-methyl Glutamyl O5MeGlu glutamic acid 5-methyl ester glutamic acid gamma-methyl ester meestere methyle Methyl Methylation methyl ester A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0259 (2S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid 3'-methyl-L-histidine MOD_RES Pros-methylhistidine N(delta)-methylhistidine N(pi)-methylhistidine NpMeHis pros-methylated L-histidine pros-methylhistidine PSI-MOD 1-methylhistidine Methyl Methylation MOD:00082 3'-methyl-L-histidine MOD:00082 A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine). PubMed:10660523 PubMed:11875433 PubMed:3467365 PubMed:6692818 PubMed:8076 PubMed:8645219 RESID:AA0073 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 9 N 3 O 1 MassAvg: 151.17 MassMono: 151.074562 Origin: H Source: natural TermSpec: none (2S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid 3'-methyl-L-histidine MOD_RES Pros-methylhistidine N(delta)-methylhistidine N(pi)-methylhistidine NpMeHis pros-methylated L-histidine pros-methylhistidine 1-methylhistidine Methyl Methylation A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0187 (5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium 2-amino-6-(trimethylammonio)hexanoic acid 5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium MOD_RES N6,N6,N6-trimethyllysine N(zeta)-trimethyllysine N-trimethylation (of lysine) N6,N6,N6-trimethyl-L-lysine N6,N6,N6-trimethylated L-lysine N6,N6,N6-trimethyllysin-N6-ium N6,N6,N6-trimethyllysine cation N6Me3+Lys epsilon-trimethyllysine PSI-MOD Trimethyl tri-Methylation MOD:00083 DeltaMass calculates the mass difference from protonated lysine rather than neutral lysine; for trimethylated lysine starting from protonated lysine see MOD:00855 N6,N6,N6-trimethyl-L-lysine MOD:00083 A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine. ChEBI:17311 PubMed:12590383 PubMed:3145979 PubMed:4304194 PubMed:6778808 PubMed:7093227 PubMed:8453381 RESID:AA0074 DiffAvg: 43.09 DiffFormula: C 3 H 7 N 0 O 0 DiffMono: 43.054227 FormalCharge: 1+ Formula: C 9 H 19 N 2 O 1 MassAvg: 171.26 MassMono: 171.149190 Origin: K Source: natural TermSpec: none (5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium 2-amino-6-(trimethylammonio)hexanoic acid 5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium MOD_RES N6,N6,N6-trimethyllysine N(zeta)-trimethyllysine N-trimethylation (of lysine) N6,N6,N6-trimethyl-L-lysine N6,N6,N6-trimethylated L-lysine N6,N6,N6-trimethyllysin-N6-ium N6,N6,N6-trimethyllysine cation N6Me3+Lys epsilon-trimethyllysine Trimethyl tri-Methylation A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0188 (2S)-2-amino-6-(dimethylamino)hexanoic acid MOD_RES N6,N6-dimethyllysine N(zeta)-dimethyllysine N6,N6-dimethyl-L-lysine N6,N6-dimethylated L-lysine N6Me2Lys dimethylk epsilon-dimethyllysine lysine derivative Lys(y) PSI-MOD Dimethyl di-Methylation MOD:00084 N6,N6-dimethyl-L-lysine MOD:00084 A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine. OMSSA:36 PubMed:10550045 PubMed:12964758 PubMed:14570711 PubMed:3100523 PubMed:8453381 RESID:AA0075 Unimod:36#K DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 8 H 16 N 2 O 1 MassAvg: 156.23 MassMono: 156.126263 Origin: K Source: natural TermSpec: none Unimod: Unimod:36 (2S)-2-amino-6-(dimethylamino)hexanoic acid MOD_RES N6,N6-dimethyllysine N(zeta)-dimethyllysine N6,N6-dimethyl-L-lysine N6,N6-dimethylated L-lysine N6Me2Lys dimethylk epsilon-dimethyllysine lysine derivative Lys(y) Dimethyl di-Methylation A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0194 (2S)-2-amino-6-methylaminohexanoic acid MOD_RES N6-methyllysine N(zeta)-methyllysine N-methyl Lysyl N6-methyl-L-lysine N6-methylated L-lysine N6Me1Lys epsilon-methyllysine PSI-MOD Methyl Methylation MOD:00085 N6-methyl-L-lysine MOD:00085 A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. ChEBI:17604 DeltaMass:165 PubMed:11875433 PubMed:3926756 RESID:AA0076 Unimod:34#K DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 14 N 2 O 1 MassAvg: 142.20 MassMono: 142.110613 Origin: K Source: natural TermSpec: none Unimod: Unimod:34 (2S)-2-amino-6-methylaminohexanoic acid MOD_RES N6-methyllysine N(zeta)-methyllysine N-methyl Lysyl N6-methyl-L-lysine N6-methylated L-lysine N6Me1Lys epsilon-methyllysine Methyl Methylation A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0197 (2S)-2-amino-6-(hexadecanoylamino)hexanoic acid 2-amino-6-(hexadecanamido)hexanoic acid LIPID N6-palmitoyl lysine N(zeta)-palmitoyllysine N6-(1-oxohexadecyl)-L-lysine N6-hexadecanoylated L-lysine N6-palmitoyl-L-lysine N6-palmitoylated L-lysine N6PamLys epsilon-palmitoyllysine palmitoylationk PSI-MOD Palmitoyl Palmitoylation MOD:00086 N6-palmitoyl-L-lysine MOD:00086 A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine. OMSSA:93 PubMed:2498336 PubMed:7801126 PubMed:7939682 RESID:AA0077 Unimod:47#K DiffAvg: 238.41 DiffFormula: C 16 H 30 N 0 O 1 DiffMono: 238.229666 Formula: C 22 H 42 N 2 O 2 MassAvg: 366.59 MassMono: 366.324629 Origin: K Source: natural TermSpec: none Unimod: Unimod:47 (2S)-2-amino-6-(hexadecanoylamino)hexanoic acid 2-amino-6-(hexadecanamido)hexanoic acid LIPID N6-palmitoyl lysine N(zeta)-palmitoyllysine N6-(1-oxohexadecyl)-L-lysine N6-hexadecanoylated L-lysine N6-palmitoyl-L-lysine N6-palmitoylated L-lysine N6PamLys epsilon-palmitoyllysine palmitoylationk Palmitoyl Palmitoylation A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0196 (2S)-2-amino-6-(tetradecanoylamino)hexanoic acid 2-amino-6-(tetradecanamido)hexanoic acid LIPID N6-myristoyl lysine N(zeta)-myristoyllysine N6-(1-oxotetradecyl)-L-lysine N6-(C14:0 aliphatic acyl)lysine N6-myristoyl-L-lysine N6-myristoylated L-lysine N6MyrLys epsilon-myristoyllysine myristoylationk PSI-MOD Myristoyl Myristoylation MOD:00087 N6-myristoyl-L-lysine MOD:00087 A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine. OMSSA:81 PubMed:1402651 PubMed:8346241 RESID:AA0078 Unimod:45#K DiffAvg: 210.36 DiffFormula: C 14 H 26 N 0 O 1 DiffMono: 210.198365 Formula: C 20 H 38 N 2 O 2 MassAvg: 338.54 MassMono: 338.293328 Origin: K Source: natural TermSpec: none Unimod: Unimod:45 (2S)-2-amino-6-(tetradecanoylamino)hexanoic acid 2-amino-6-(tetradecanamido)hexanoic acid LIPID N6-myristoyl lysine N(zeta)-myristoyllysine N6-(1-oxotetradecyl)-L-lysine N6-(C14:0 aliphatic acyl)lysine N6-myristoyl-L-lysine N6-myristoylated L-lysine N6MyrLys epsilon-myristoyllysine myristoylationk Myristoyl Myristoylation A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0242 (2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid L-threonine hexadecanoate ester LIPID O-palmitoyl threonine O-hexadecanoylated L-threonine O-palmitoyl-L-threonine O-palmitoylated L-threonine O3-palmitoyl-threonine OPamThr palmitoylationt threonine palmitate ester PSI-MOD Palmitoyl Palmitoylation MOD:00088 O-palmitoyl-L-threonine MOD:00088 A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine. OMSSA:95 PubMed:6642431 PubMed:8413602 RESID:AA0079 Unimod:47#T DiffAvg: 238.41 DiffFormula: C 16 H 30 N 0 O 1 DiffMono: 238.229666 Formula: C 20 H 37 N 1 O 3 MassAvg: 339.52 MassMono: 339.277344 Origin: T Source: natural TermSpec: none Unimod: Unimod:47 (2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid L-threonine hexadecanoate ester LIPID O-palmitoyl threonine O-hexadecanoylated L-threonine O-palmitoyl-L-threonine O-palmitoylated L-threonine O3-palmitoyl-threonine OPamThr palmitoylationt threonine palmitate ester Palmitoyl Palmitoylation A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0241 (2S)-2-amino-3-(hexadecanoyloxy)propanoic acid ACT_SITE O-palmitoyl serine intermediate L-serine hexadecanoate ester LIPID O-palmitoyl serine O-hexadecanoylated L-serine O-palmitoyl-L-serine O-palmitoylated L-serine O3-palmitoyl-serine OPamSer palmitoylations serine palmitate ester PSI-MOD Palmitoyl Palmitoylation MOD:00089 O-palmitoyl-L-serine MOD:00089 A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine. OMSSA:94 PubMed:3467339 RESID:AA0080 Unimod:47#S DiffAvg: 238.41 DiffFormula: C 16 H 30 N 0 O 1 DiffMono: 238.229666 Formula: C 19 H 35 N 1 O 3 MassAvg: 325.49 MassMono: 325.261694 Origin: S Source: natural TermSpec: none Unimod: Unimod:47 (2S)-2-amino-3-(hexadecanoyloxy)propanoic acid ACT_SITE O-palmitoyl serine intermediate L-serine hexadecanoate ester LIPID O-palmitoyl serine O-hexadecanoylated L-serine O-palmitoyl-L-serine O-palmitoylated L-serine O3-palmitoyl-serine OPamSer palmitoylations serine palmitate ester Palmitoyl Palmitoylation A protein modification that effectively converts an L-alanine residue to L-alanine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0057 (2S)-2-aminopropanamide AlaN L-alanine amide MOD_RES Alanine amide alaninamide amidated L-alanine PSI-MOD MOD:00090 L-alanine amide MOD:00090 A protein modification that effectively converts an L-alanine residue to L-alanine amide. PubMed:1377792 PubMed:2069951 PubMed:8472537 PubMed:952951 RESID:AA0081 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 3 H 7 N 2 O 1 MassAvg: 87.10 MassMono: 87.055838 Origin: A Source: natural TermSpec: C-term (2S)-2-aminopropanamide AlaN L-alanine amide MOD_RES Alanine amide alaninamide amidated L-alanine A protein modification that effectively converts an L-arginine residue to L-arginine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0060 (2S)-2-amino-5-[(diaminomethylidene)amino]pentanamide 2-amino-5-carbamimidamidopentanamide 2-amino-5-guanidinopentanamide ArgN L-arginine amide MOD_RES Arginine amide amidated L-arginine argininamide PSI-MOD MOD:00091 L-arginine amide MOD:00091 A protein modification that effectively converts an L-arginine residue to L-arginine amide. ChEBI:145897 PubMed:2229025 PubMed:2753890 PubMed:743209 RESID:AA0082 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 6 H 14 N 5 O 1 MassAvg: 172.21 MassMono: 172.119835 Origin: R Source: natural TermSpec: C-term (2S)-2-amino-5-[(diaminomethylidene)amino]pentanamide 2-amino-5-carbamimidamidopentanamide 2-amino-5-guanidinopentanamide ArgN L-arginine amide MOD_RES Arginine amide amidated L-arginine argininamide A protein modification that effectively converts an L-asparagine residue to L-asparagine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0062 (2S)-2-aminobutanediamide AsnN L-asparagine amide MOD_RES Asparagine amide amidated L-asparagine asparaginamide PSI-MOD MOD:00092 L-asparagine amide MOD:00092 A protein modification that effectively converts an L-asparagine residue to L-asparagine amide. ChEBI:145898 PubMed:2753132 PubMed:279902 PubMed:3415690 RESID:AA0083 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 4 H 8 N 3 O 2 MassAvg: 130.13 MassMono: 130.061652 Origin: N Source: natural TermSpec: C-term (2S)-2-aminobutanediamide AsnN L-asparagine amide MOD_RES Asparagine amide amidated L-asparagine asparaginamide A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0063 (2S)-2-amino-1-butanediamic acid 1-amidated L-aspartic acid 3,4-diamino-4-oxobutanoic acid 3-amino-succinamic acid AspN L-aspartic acid 1-amide MOD_RES Aspartic acid 1-amide alpha-asparagine isoasparagine PSI-MOD MOD:00093 L-aspartic acid 1-amide MOD:00093 A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide. PubMed:2542051 RESID:AA0084 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 4 H 7 N 2 O 3 MassAvg: 131.11 MassMono: 131.045667 Origin: D Source: natural TermSpec: C-term (2S)-2-amino-1-butanediamic acid 1-amidated L-aspartic acid 3,4-diamino-4-oxobutanoic acid 3-amino-succinamic acid AspN L-aspartic acid 1-amide MOD_RES Aspartic acid 1-amide alpha-asparagine isoasparagine A protein modification that effectively converts an L-cysteine residue to L-cysteine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0102 (2R)-2-amino-3-sulfanylpropanamide 2-amino-3-mercaptopropanamide CysN L-cysteine amide MOD_RES Cysteine amide amidated L-cysteine cysteinamide PSI-MOD MOD:00094 L-cysteine amide MOD:00094 A protein modification that effectively converts an L-cysteine residue to L-cysteine amide. PubMed:1892838 PubMed:7149738 RESID:AA0085 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 S 0 DiffMono: -0.984016 Formula: C 3 H 7 N 2 O 1 S 1 MassAvg: 119.16 MassMono: 119.027909 Origin: C Source: natural TermSpec: C-term (2R)-2-amino-3-sulfanylpropanamide 2-amino-3-mercaptopropanamide CysN L-cysteine amide MOD_RES Cysteine amide amidated L-cysteine cysteinamide A protein modification that effectively converts an L-glutamine residue to L-glutamine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0130 (2S)-2-aminopentanediamide GlnN L-glutamine amide MOD_RES Glutamine amide amidated L-glutamine glutaminamide PSI-MOD MOD:00095 L-glutamine amide MOD:00095 A protein modification that effectively converts an L-glutamine residue to L-glutamine amide. PubMed:7673220 PubMed:9048550 RESID:AA0086 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 5 H 10 N 3 O 2 MassAvg: 144.15 MassMono: 144.077302 Origin: Q Source: natural TermSpec: C-term (2S)-2-aminopentanediamide GlnN L-glutamine amide MOD_RES Glutamine amide amidated L-glutamine glutaminamide A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0129 (2S)-2-amino-1-pentanediamic acid 1-amidated L-glutamic acid 4,5-diamino-5-oxopentanoic acid GluN L-glutamic acid 1-amide MOD_RES Glutamic acid 1-amide isoglutamine PSI-MOD MOD:00096 L-glutamic acid 1-amide MOD:00096 A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide. PubMed:1093875 PubMed:14550575 RESID:AA0087 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 5 H 9 N 2 O 3 MassAvg: 145.14 MassMono: 145.061317 Origin: E Source: natural TermSpec: C-term (2S)-2-amino-1-pentanediamic acid 1-amidated L-glutamic acid 4,5-diamino-5-oxopentanoic acid GluN L-glutamic acid 1-amide MOD_RES Glutamic acid 1-amide isoglutamine A protein modification that effectively converts a glycine residue to glycine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0132 2-aminoacetamide 2-aminoethanamide 2-azanylethanamide GlyN MOD_RES Glycine amide amidated glycine glycinamide glycine amide PSI-MOD MOD:00097 glycine amide MOD:00097 A protein modification that effectively converts a glycine residue to glycine amide. PubMed:13591312 RESID:AA0088 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 2 H 5 N 2 O 1 MassAvg: 73.07 MassMono: 73.040188 Origin: G Source: natural TermSpec: C-term 2-aminoacetamide 2-aminoethanamide 2-azanylethanamide GlyN MOD_RES Glycine amide amidated glycine glycinamide glycine amide A protein modification that effectively converts an L-histidine residue to L-histidine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0148 (2S)-2-amino-3-(1H-imidazol-4-yl)propanamide HisN L-histidine amide MOD_RES Histidine amide amidated L-histidine histidinamide PSI-MOD MOD:00098 L-histidine amide MOD:00098 A protein modification that effectively converts an L-histidine residue to L-histidine amide. PubMed:2153586 PubMed:2307683 PubMed:2839478 RESID:AA0089 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 6 H 9 N 4 O 1 MassAvg: 153.16 MassMono: 153.077636 Origin: H Source: natural TermSpec: C-term (2S)-2-amino-3-(1H-imidazol-4-yl)propanamide HisN L-histidine amide MOD_RES Histidine amide amidated L-histidine histidinamide A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0161 (2S,3S)-2-amino-3-methylpentanamide IleN L-isoleucine amide MOD_RES Isoleucine amide amidated L-isoleucine isoleucinamide PSI-MOD MOD:00099 L-isoleucine amide MOD:00099 A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide. RESID:AA0090 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 6 H 13 N 2 O 1 MassAvg: 129.18 MassMono: 129.102788 Origin: I Source: natural TermSpec: C-term (2S,3S)-2-amino-3-methylpentanamide IleN L-isoleucine amide MOD_RES Isoleucine amide amidated L-isoleucine isoleucinamide A protein modification that effectively converts an L-leucine residue to L-leucine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0166 (2S)-2-amino-4-methylpentanamide 2-amino-4-methylvaleramide 2-azanyl-4-methylpentanamide L-leucine amide LeuN MOD_RES Leucine amide alpha-aminoisocaproamide amidated L-leucine leucinamide PSI-MOD MOD:00100 L-leucine amide MOD:00100 A protein modification that effectively converts an L-leucine residue to L-leucine amide. PubMed:2578459 RESID:AA0091 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 6 H 13 N 2 O 1 MassAvg: 129.18 MassMono: 129.102788 Origin: L Source: natural TermSpec: C-term (2S)-2-amino-4-methylpentanamide 2-amino-4-methylvaleramide 2-azanyl-4-methylpentanamide L-leucine amide LeuN MOD_RES Leucine amide alpha-aminoisocaproamide amidated L-leucine leucinamide A protein modification that effectively converts an L-lysine residue to L-lysine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0168 (2S)-2,6-diaminohexanamide L-lysine amide LysN MOD_RES Lysine amide amidated L-lysine lysinamide PSI-MOD MOD:00101 L-lysine amide MOD:00101 A protein modification that effectively converts an L-lysine residue to L-lysine amide. PubMed:6579533 RESID:AA0092 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 6 H 14 N 3 O 1 MassAvg: 144.20 MassMono: 144.113687 Origin: K Source: natural TermSpec: C-term (2S)-2,6-diaminohexanamide L-lysine amide LysN MOD_RES Lysine amide amidated L-lysine lysinamide A protein modification that effectively converts an L-methionine residue to L-methionine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0164 (2S)-2-amino-4-(methylsulfanyl)butanamide 2-amino-4-(methylthio)butanamide L-methionine amide MOD_RES Methionine amide MetN amidated L-methionine methioninamide PSI-MOD MOD:00102 L-methionine amide MOD:00102 A protein modification that effectively converts an L-methionine residue to L-methionine amide. PubMed:4375977 RESID:AA0093 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 S 0 DiffMono: -0.984016 Formula: C 5 H 11 N 2 O 1 S 1 MassAvg: 147.22 MassMono: 147.059209 Origin: M Source: natural TermSpec: C-term (2S)-2-amino-4-(methylsulfanyl)butanamide 2-amino-4-(methylthio)butanamide L-methionine amide MOD_RES Methionine amide MetN amidated L-methionine methioninamide A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0248 (2S)-2-amino-3-phenylpropanamide L-phenylalanine amide MOD_RES Phenylalanine amide PheN amidated L-phenylalanine phenylalaninamide PSI-MOD MOD:00103 L-phenylalanine amide MOD:00103 A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide. PubMed:2905621 PubMed:8868490 RESID:AA0094 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 9 H 11 N 2 O 1 MassAvg: 163.20 MassMono: 163.087138 Origin: F Source: natural TermSpec: C-term (2S)-2-amino-3-phenylpropanamide L-phenylalanine amide MOD_RES Phenylalanine amide PheN amidated L-phenylalanine phenylalaninamide A protein modification that effectively converts an L-proline residue to L-proline amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0257 (2S)-pyrrolidine-2-carboxamide L-proline amide MOD_RES Proline amide ProN amidated L-proline prolinamide PSI-MOD MOD:00104 L-proline amide MOD:00104 A protein modification that effectively converts an L-proline residue to L-proline amide. PubMed:4982117 PubMed:5760861 RESID:AA0095 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 5 H 9 N 2 O 1 MassAvg: 113.14 MassMono: 113.071488 Origin: P Source: natural TermSpec: C-term (2S)-pyrrolidine-2-carboxamide L-proline amide MOD_RES Proline amide ProN amidated L-proline prolinamide A protein modification that effectively converts an L-serine residue to L-serine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0275 (2S)-2-amino-3-hydroxypropanamide L-serine amide MOD_RES Serine amide SerN amidated L-serine serinamide PSI-MOD MOD:00105 L-serine amide MOD:00105 A protein modification that effectively converts an L-serine residue to L-serine amide. PubMed:743209 RESID:AA0096 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 3 H 7 N 2 O 2 MassAvg: 103.10 MassMono: 103.050752 Origin: S Source: natural TermSpec: C-term (2S)-2-amino-3-hydroxypropanamide L-serine amide MOD_RES Serine amide SerN amidated L-serine serinamide A protein modification that effectively converts an L-threonine residue to L-threonine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0293 (2S,3R)-2-amino-3-hydroxybutanamide L-threonine amide MOD_RES Threonine amide ThrN amidated L-threonine threoninamide PSI-MOD MOD:00106 L-threonine amide MOD:00106 A protein modification that effectively converts an L-threonine residue to L-threonine amide. PubMed:1390774 RESID:AA0097 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 4 H 9 N 2 O 2 MassAvg: 117.13 MassMono: 117.066403 Origin: T Source: natural TermSpec: C-term (2S,3R)-2-amino-3-hydroxybutanamide L-threonine amide MOD_RES Threonine amide ThrN amidated L-threonine threoninamide A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0296 (2S)-2-amino-3-(1H-indol-3-yl)propanamide L-tryptophan amide MOD_RES Tryptophan amide TrpN amidated L-tryptophan tryptophanamide PSI-MOD MOD:00107 L-tryptophan amide MOD:00107 A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide. PubMed:3947348 RESID:AA0098 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 11 H 12 N 3 O 1 MassAvg: 202.24 MassMono: 202.098037 Origin: W Source: natural TermSpec: C-term (2S)-2-amino-3-(1H-indol-3-yl)propanamide L-tryptophan amide MOD_RES Tryptophan amide TrpN amidated L-tryptophan tryptophanamide A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0302 (2S)-2-amino-3-(4-hydoxyphenyl)propanamide L-tyrosine amide MOD_RES Tyrosine amide TyrN amidated L-tyrosine tyrosinamide PSI-MOD MOD:00108 L-tyrosine amide MOD:00108 A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide. PubMed:1377792 PubMed:3562898 PubMed:6509012 RESID:AA0099 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 9 H 11 N 2 O 2 MassAvg: 179.20 MassMono: 179.082053 Origin: Y Source: natural TermSpec: C-term (2S)-2-amino-3-(4-hydoxyphenyl)propanamide L-tyrosine amide MOD_RES Tyrosine amide TyrN amidated L-tyrosine tyrosinamide A protein modification that effectively converts an L-valine residue to L-valine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0303 (2S)-2-amino-3-methylbutanamide L-valine amide MOD_RES Valine amide ValN valinamide PSI-MOD MOD:00109 L-valine amide MOD:00109 A protein modification that effectively converts an L-valine residue to L-valine amide. PubMed:2578459 PubMed:5465996 RESID:AA0100 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 5 H 11 N 2 O 1 MassAvg: 115.16 MassMono: 115.087138 Origin: V Source: natural TermSpec: C-term (2S)-2-amino-3-methylbutanamide L-valine amide MOD_RES Valine amide ValN valinamide A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0104 (2R)-2-amino-3-(methyldisulfanediyl)propanoic acid 2-amino-3-(methyldisulfanediyl)propanoic acid 2-amino-3-(methyldithio)propanoic acid 2-amino-3-methyldisulfanylpropanoic acid 2-azanyl-3-(methyldisulfanediyl)-propanoic acid L-3-(methyldithio)alanine L-cysteine methyl disulfide MOD_RES Cysteine methyl disulfide S-methylthio-L-cysteine S-methylthiocysteine methyl methanethiolsulfonate derivatized cysteine methyl methanethiosulfonate derivatized cysteine mmts PSI-MOD Beta-methylthiolation Methylthio MOD:00110 Produced artifactually by reaction of cysteine residues with methyl methanethiosulfonate (MMTS) [JSG], but also naturally in bacteria [PMT]. L-cysteine methyl disulfide MOD:00110 A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide. OMSSA:179 PubMed:10555576 PubMed:163643 PubMed:2056535 PubMed:6381494 RESID:AA0101 Unimod:39#C DiffAvg: 46.09 DiffFormula: C 1 H 2 N 0 O 0 S 1 DiffMono: 45.987721 Formula: C 4 H 7 N 1 O 1 S 2 MassAvg: 149.23 MassMono: 148.996906 Origin: C Source: natural TermSpec: none Unimod: Unimod:39 (2R)-2-amino-3-(methyldisulfanediyl)propanoic acid 2-amino-3-(methyldisulfanediyl)propanoic acid 2-amino-3-(methyldithio)propanoic acid 2-amino-3-methyldisulfanylpropanoic acid 2-azanyl-3-(methyldisulfanediyl)-propanoic acid L-3-(methyldithio)alanine L-cysteine methyl disulfide MOD_RES Cysteine methyl disulfide S-methylthio-L-cysteine S-methylthiocysteine methyl methanethiolsulfonate derivatized cysteine methyl methanethiosulfonate derivatized cysteine mmts Beta-methylthiolation Methylthio Methylthio A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0277 (2R)-2-amino-3-([(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid LIPID S-farnesyl cysteine S-farnesyl Cystenyl S-farnesyl-L-cysteine SFarnCys farnesylationc PSI-MOD Farnesyl Farnesylation MOD:00111 From DeltaMass: (name misspelled "S-farnesyl cystenyl") S-farnesyl-L-cysteine MOD:00111 A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine. DeltaMass:293 OMSSA:42 PubMed:1409665 PubMed:15609361 PubMed:1872463 PubMed:2684976 RESID:AA0102 Unimod:44#C DiffAvg: 204.36 DiffFormula: C 15 H 24 N 0 O 0 S 0 DiffMono: 204.187801 Formula: C 18 H 29 N 1 O 1 S 1 MassAvg: 307.50 MassMono: 307.196986 Origin: C Source: natural TermSpec: none Unimod: Unimod:44 (2R)-2-amino-3-([(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid LIPID S-farnesyl cysteine S-farnesyl Cystenyl S-farnesyl-L-cysteine SFarnCys farnesylationc Farnesyl Farnesylation A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0269 (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid LIPID S-12-hydroxyfarnesyl cysteine S-12-hydroxyfarnesyl-L-cysteine S12HyFarnCys PSI-MOD Hydroxyfarnesyl hydroxyfarnesyl MOD:00112 S-12-hydroxyfarnesyl-L-cysteine MOD:00112 A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine. PubMed:17790543 RESID:AA0103 Unimod:376 DiffAvg: 220.36 DiffFormula: C 15 H 24 N 0 O 1 S 0 DiffMono: 220.182715 Formula: C 18 H 29 N 1 O 2 S 1 MassAvg: 323.50 MassMono: 323.191900 Origin: C Source: natural TermSpec: none Unimod: Unimod:376 (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid LIPID S-12-hydroxyfarnesyl cysteine S-12-hydroxyfarnesyl-L-cysteine S12HyFarnCys Hydroxyfarnesyl hydroxyfarnesyl A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0278 (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid LIPID S-geranylgeranyl cysteine S-geranylgeranyl S-geranylgeranyl-L-cysteine SGergerCys geranylgeranylc PSI-MOD Geranyl-geranyl GeranylGeranyl MOD:00113 DeltaMass calculates the mass with two double bonds rather than four S-geranylgeranyl-L-cysteine MOD:00113 A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine. DeltaMass:0 OMSSA:49 PubMed:1483450 PubMed:15609361 RESID:AA0104 Unimod:48#C DiffAvg: 272.48 DiffFormula: C 20 H 32 N 0 O 0 S 0 DiffMono: 272.250401 Formula: C 23 H 37 N 1 O 1 S 1 MassAvg: 375.62 MassMono: 375.259586 Origin: C Source: natural TermSpec: none Unimod: Unimod:48 (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid LIPID S-geranylgeranyl cysteine S-geranylgeranyl S-geranylgeranyl-L-cysteine SGergerCys geranylgeranylc Geranyl-geranyl GeranylGeranyl A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0105 2-amino-3-mercaptopropanoic methyl ester 2-amino-3-sulfanylpropanoic methyl ester L-cysteine methyl ester MOD_RES Cysteine methyl ester OMeCys mecysteine methyl (2R)-2-amino-3-sulfanylpropanoate methyl L-cysteinate methyl esterified L-cysteine PSI-MOD Methyl Methylation MOD:00114 Secondary to RESID:AA0102; secondary to RESID:AA0103; secondary to RESID:AA0104. L-cysteine methyl ester MOD:00114 A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester. PubMed:11875433 PubMed:1872463 RESID:AA0105 Unimod:34#C-term DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 S 0 DiffMono: 14.015650 Formula: C 4 H 8 N 1 O 2 S 1 MassAvg: 134.17 MassMono: 134.027574 Origin: C Source: natural TermSpec: C-term Unimod: Unimod:34 2-amino-3-mercaptopropanoic methyl ester 2-amino-3-sulfanylpropanoic methyl ester L-cysteine methyl ester MOD_RES Cysteine methyl ester OMeCys mecysteine methyl (2R)-2-amino-3-sulfanylpropanoate methyl L-cysteinate methyl esterified L-cysteine Methyl Methylation A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0281 (2R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid 2-amino-3-(hexadecanoylthio)propanoic acid ACT_SITE S-palmitoyl cysteine intermediate LIPID S-palmitoyl cysteine S-hexadecanoylated L-cysteine S-palmitoyl-L-cysteine S-palmitoylated L-cysteine S-palmityl Cystenyl SPamCys cysteine hexadecanoate thioester cysteine palmitate thioester PSI-MOD Palmitoyl Palmitoylation MOD:00115 From DeltaMass: (name misspelled "S-palmityl Cystenyl" and formula incorrect, N and O reversed) Formula: C19H35O1N2S1 Monoisotopic Mass Change: 341.239 Average Mass Change: 341.556 S-palmitoyl-L-cysteine MOD:00115 A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine. DeltaMass:303 PubMed:1872406 PubMed:3166978 PubMed:8180229 PubMed:8824274 RESID:AA0106 Unimod:47#C DiffAvg: 238.41 DiffFormula: C 16 H 30 N 0 O 1 S 0 DiffMono: 238.229666 Formula: C 19 H 35 N 1 O 2 S 1 MassAvg: 341.55 MassMono: 341.238850 Origin: C Source: natural TermSpec: none Unimod: Unimod:47 (2R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid 2-amino-3-(hexadecanoylthio)propanoic acid ACT_SITE S-palmitoyl cysteine intermediate LIPID S-palmitoyl cysteine S-hexadecanoylated L-cysteine S-palmitoyl-L-cysteine S-palmitoylated L-cysteine S-palmityl Cystenyl SPamCys cysteine hexadecanoate thioester cysteine palmitate thioester Palmitoyl Palmitoylation A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine. Origin: Source: TermSpec: uniprot.ptm:PTM-0274 (2R)-2-amino-3-[(2S)-2-((9Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid 2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid LIPID S-diacylglycerol cysteine S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine S-(2',3'-diacylglycerol)-L-cysteine S-diacylglycerol-L-cysteine SAcyl2GlyceroCys PSI-MOD Diacylglycerol diacylglycerol MOD:00116 Incidental to RESID:AA0060. S-diacylglycerol-L-cysteine MOD:00116 A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine. PubMed:10896212 PubMed:4575979 PubMed:9056182 RESID:AA0107 Unimod:377#C Origin: C Source: natural TermSpec: none (2R)-2-amino-3-[(2S)-2-((9Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid 2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid LIPID S-diacylglycerol cysteine S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine S-(2',3'-diacylglycerol)-L-cysteine S-diacylglycerol-L-cysteine SAcyl2GlyceroCys Diacylglycerol diacylglycerol A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0156 (2S)-2-amino-5-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-oxopentanoic acid (S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid 2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid CROSSLNK Isoglutamyl cysteine thioester (Cys-Gln) S-(L-isoglutamyl)-L-cysteine S-gamma-glutamyl (crosslinked to cysteine) XLNK-SCys-5Glu(Gln) gamma-(S-cysteinyl)glutamic acid PSI-MOD MOD:00117 Cross-link 2; DeltaMass calculates the mass difference from glutamic acid rather than glutamine. S-(L-isoglutamyl)-L-cysteine MOD:00117 A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia. ChEBI:22021 DeltaMass:0 PubMed:6838833 RESID:AA0108 DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 S 0 DiffMono: -17.026549 Formula: C 8 H 10 N 2 O 3 S 1 MassAvg: 214.24 MassMono: 214.041213 Origin: C, Q Source: natural TermSpec: none (2S)-2-amino-5-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-oxopentanoic acid (S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid 2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid CROSSLNK Isoglutamyl cysteine thioester (Cys-Gln) S-(L-isoglutamyl)-L-cysteine S-gamma-glutamyl (crosslinked to cysteine) XLNK-SCys-5Glu(Gln) gamma-(S-cysteinyl)glutamic acid A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0005 (2R)-2-amino-3-[(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)sulfanyl]propanoic acid (2S)-2-amino-3-[2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-1H-imidazol-4-yl]propanoic acid 2'-(L-cystein-S-yl)-L-histidine CROSSLNK 2'-(S-cysteinyl)-histidine (Cys-His) S-(2'-histidyl)cysteine S-(2-histidyl)- (crosslinked to cysteine) XLNK-SCys-2'His PSI-MOD MOD:00118 Cross-link 2. 2'-(S-L-cysteinyl)-L-histidine MOD:00118 A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine. DeltaMass:0 PubMed:6210696 RESID:AA0109 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 9 H 10 N 4 O 2 S 1 MassAvg: 238.26 MassMono: 238.052447 Origin: C, H Source: natural TermSpec: none (2R)-2-amino-3-[(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)sulfanyl]propanoic acid (2S)-2-amino-3-[2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-1H-imidazol-4-yl]propanoic acid 2'-(L-cystein-S-yl)-L-histidine CROSSLNK 2'-(S-cysteinyl)-histidine (Cys-His) S-(2'-histidyl)cysteine S-(2-histidyl)- (crosslinked to cysteine) XLNK-SCys-2'His A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) (R)-S-(2-amino-2-carboxyethyl)-L-cysteine (R,R)-2,6-diamino-4-thiaheptanedioic acid (R,R)-3,3'-thiobis-(2-aminopropanoic acid) (R,R)-bis(2-amino-2-carboxyethyl)sulfide 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid 3,3'-thiobis-L-alanine L-lanthionine XLNK-SCys-(L)3Dha PSI-MOD MOD:00119 Cross-link 2. The natural occurrence of this modification is rare. For the more common modification see MOD:00120 meso-lanthionine [JSG]. L-lanthionine (Cys-Ser) MOD:00119 A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. ChEBI:21347 DeltaMass:7 RESID:AA0110#CSX DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 6 H 8 N 2 O 2 S 1 MassAvg: 172.20 MassMono: 172.030649 Origin: C, S Source: artifact TermSpec: none (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) (R)-S-(2-amino-2-carboxyethyl)-L-cysteine (R,R)-2,6-diamino-4-thiaheptanedioic acid (R,R)-3,3'-thiobis-(2-aminopropanoic acid) (R,R)-bis(2-amino-2-carboxyethyl)sulfide 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid 3,3'-thiobis-L-alanine L-lanthionine XLNK-SCys-(L)3Dha A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0164 (2R,2'S)-3,3'-sulfanediylbis(2-aminopropanoic acid) (2R,2'S)-3,3'-thiobis-(2-aminopropanoic acid) (2R,6S)-2,6-diamino-4-thiaheptanedioic acid (2R,6S)-meso-lanthionine (2S)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]propanoic acid (R)-S-(2-amino-2-carboxyethyl)-D-cysteine (R,S)-bis(2-amino-2-carboxyethyl)sulfide 3,3'-thiobis-meso-alanine CROSSLNK Lanthionine (Cys-Ser) CROSSLNK Lanthionine (Ser-Cys) XLNK-SCys-(D)3Dha cysteine-3-D-alanine thioether meso-lanthionine PSI-MOD (2S,6R)-meso-lanthionine MOD:00120 Cross-link 2. meso-lanthionine MOD:00120 A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine. PubMed:15023056 PubMed:3769923 RESID:AA0111 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 6 H 8 N 2 O 2 S 1 MassAvg: 172.20 MassMono: 172.030649 Origin: C, S Source: natural TermSpec: none (2R,2'S)-3,3'-sulfanediylbis(2-aminopropanoic acid) (2R,2'S)-3,3'-thiobis-(2-aminopropanoic acid) (2R,6S)-2,6-diamino-4-thiaheptanedioic acid (2R,6S)-meso-lanthionine (2S)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]propanoic acid (R)-S-(2-amino-2-carboxyethyl)-D-cysteine (R,S)-bis(2-amino-2-carboxyethyl)sulfide 3,3'-thiobis-meso-alanine CROSSLNK Lanthionine (Cys-Ser) CROSSLNK Lanthionine (Ser-Cys) XLNK-SCys-(D)3Dha cysteine-3-D-alanine thioether meso-lanthionine (2S,6R)-meso-lanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0067 (2S,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid (2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid (2S,3S,2'R)-3-methyllanthionine (2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid (2S,3S,6R)-3-methyllanthionine (2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid 3-methyl-D,L-lanthionine CROSSLNK Beta-methyllanthionine (Cys-Thr) CROSSLNK Beta-methyllanthionine (Thr-Cys) XLNK-SCys-3Dhb cysteine-3-D-butyrine thioether PSI-MOD MOD:00121 Cross-link 2. (2S,3S,2'R)-3-methyllanthionine MOD:00121 A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine. PubMed:3769923 RESID:AA0112 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 7 H 10 N 2 O 2 S 1 MassAvg: 186.23 MassMono: 186.046299 Origin: C, T Source: natural TermSpec: none (2S,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid (2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid (2S,3S,2'R)-3-methyllanthionine (2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid (2S,3S,6R)-3-methyllanthionine (2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid 3-methyl-D,L-lanthionine CROSSLNK Beta-methyllanthionine (Cys-Thr) CROSSLNK Beta-methyllanthionine (Thr-Cys) XLNK-SCys-3Dhb cysteine-3-D-butyrine thioether A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0019 (2S)-2-amino-3-(3-[(2R)2-amino-2-carboxyethylsulfanyl]-4-hydroxyphenyl)propanoic acid 2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid 3'-(L-cystein-S-yl)-L-tyrosine 3'-(cystein-S-yl)tyrosine CROSSLNK 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) CROSSLNK 3'-(S-cysteinyl)-tyrosine (Tyr-Cys) S-(3-Tyr) (Crosslinked to Cysteine) S-(tyros-3'-yl)cysteine XLNK-SCys-3'Tyr PSI-MOD MOD:00122 Cross-link 2. 3'-(S-L-cysteinyl)-L-tyrosine MOD:00122 A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine. DeltaMass:0 PubMed:15917234 PubMed:2002850 RESID:AA0113 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 12 H 12 N 2 O 3 S 1 MassAvg: 264.30 MassMono: 264.056863 Origin: C, Y Source: natural TermSpec: none (2S)-2-amino-3-(3-[(2R)2-amino-2-carboxyethylsulfanyl]-4-hydroxyphenyl)propanoic acid 2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid 3'-(L-cystein-S-yl)-L-tyrosine 3'-(cystein-S-yl)tyrosine CROSSLNK 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) CROSSLNK 3'-(S-cysteinyl)-tyrosine (Tyr-Cys) S-(3-Tyr) (Crosslinked to Cysteine) S-(tyros-3'-yl)cysteine XLNK-SCys-3'Tyr A protein modification that effectively converts an L-lysine residue to N6-carboxy-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0191 (2S)-2-amino-6-(carboxyamino)hexanoic acid 2-amino-6-carbamic hexanoic acid MOD_RES N6-carboxylysine N6-carboxy-L-lysine N6-carboxylysine N6CbxLys lysine NZ-carboxylic acid PSI-MOD Carboxy Carboxylation N6-carbamyllysine MOD:00123 N6-carboxy-L-lysine MOD:00123 A protein modification that effectively converts an L-lysine residue to N6-carboxy-L-lysine. PubMed:11369851 PubMed:4436319 PubMed:637859 PubMed:7754395 RESID:AA0114 Unimod:299#K DiffAvg: 44.01 DiffFormula: C 1 H 0 N 0 O 2 DiffMono: 43.989829 Formula: C 7 H 12 N 2 O 3 MassAvg: 172.18 MassMono: 172.084792 Origin: K Source: natural TermSpec: none Unimod: Unimod:299 (2S)-2-amino-6-(carboxyamino)hexanoic acid 2-amino-6-carbamic hexanoic acid MOD_RES N6-carboxylysine N6-carboxy-L-lysine N6-carboxylysine N6CbxLys lysine NZ-carboxylic acid Carboxy Carboxylation N6-carbamyllysine A protein modification that effectively converts an L-lysine residue to N6-1-carboxyethyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0189 (2S)-2-amino-6-([(1S)-1-carboxyethyl]amino)hexanoic acid MOD_RES N6-1-carboxyethyl lysine N6-(1-carboxyethyl)-L-lysine N6-(1-carboxyethyl)lysine N6CbzEtLys NZ-(1-carboxyethyl)lysine PSI-MOD Carboxyethyl carboxyethyl MOD:00124 N6-1-carboxyethyl-L-lysine MOD:00124 A protein modification that effectively converts an L-lysine residue to N6-1-carboxyethyl-L-lysine. PubMed:3123486 PubMed:8253186 PubMed:8421682 RESID:AA0115 Unimod:378#K DiffAvg: 72.06 DiffFormula: C 3 H 4 N 0 O 2 DiffMono: 72.021129 Formula: C 9 H 16 N 2 O 3 MassAvg: 200.24 MassMono: 200.116092 Origin: K Source: natural TermSpec: none Unimod: Unimod:378 (2S)-2-amino-6-([(1S)-1-carboxyethyl]amino)hexanoic acid MOD_RES N6-1-carboxyethyl lysine N6-(1-carboxyethyl)-L-lysine N6-(1-carboxyethyl)lysine N6CbzEtLys NZ-(1-carboxyethyl)lysine Carboxyethyl carboxyethyl A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0150 (2S)-2-amino-6-([(2R)-4-amino-2-hydroxybutyl]amino)hexanoic acid (2S,9R)-2,11-diazanyl-9-hydroxy-7-azaundecanoic acid (2S,9R)-hypusine 2-azanyl-6-[(4-azanyl-2-hydroxybutyl)azanyl]hexanoic acid Hypu L-hypusine MOD_RES Hypusine N-(4-NH2-2-OH-butyl)- (of Lysine) N6-(4-amino-2-hydroxybutyl)-L-lysine PSI-MOD Hypusine hypusine MOD:00125 This modification occurs uniquely in translation initiation factor eIF-5A [JSG]. hypusine MOD:00125 A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. DeltaMass:0 PubMed:6806267 PubMed:8108861 RESID:AA0116 Unimod:379#K DiffAvg: 87.12 DiffFormula: C 4 H 9 N 1 O 1 DiffMono: 87.068414 Formula: C 10 H 21 N 3 O 2 MassAvg: 215.30 MassMono: 215.163377 Origin: K Source: natural TermSpec: none Unimod: Unimod:379 (2S)-2-amino-6-([(2R)-4-amino-2-hydroxybutyl]amino)hexanoic acid (2S,9R)-2,11-diazanyl-9-hydroxy-7-azaundecanoic acid (2S,9R)-hypusine 2-azanyl-6-[(4-azanyl-2-hydroxybutyl)azanyl]hexanoic acid Hypu L-hypusine MOD_RES Hypusine N-(4-NH2-2-OH-butyl)- (of Lysine) N6-(4-amino-2-hydroxybutyl)-L-lysine Hypusine hypusine A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0382 (2S)-2-amino-6-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoylamino)hexanoic acid (3aS-(3aalpha,4beta,6aalpha))-N6-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-L-lysine MOD_RES N6-biotinyllysine N6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine N6-biotinyl-L-lysine N6-biotinyllysine N6BtnLys biocytin biotinyl lysyl epsilon-N-biotinyllysine PSI-MOD Biotin Biotinylation MOD:00126 From DeltaMass: Average Mass: 354 Formula:C 16 H 26 O 4 N 3 S 1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:354.172 Average Mass Change:354.471 References:PE Sciex. N6-biotinyl-L-lysine MOD:00126 A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine. DeltaMass:305 PubMed:16109483 PubMed:3178228 PubMed:7948875 PubMed:8747466 RESID:AA0117 Unimod:3#K DiffAvg: 226.29 DiffFormula: C 10 H 14 N 2 O 2 S 1 DiffMono: 226.077599 Formula: C 16 H 26 N 4 O 3 S 1 MassAvg: 354.47 MassMono: 354.172562 Origin: K Source: natural TermSpec: none Unimod: Unimod:3 (2S)-2-amino-6-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoylamino)hexanoic acid (3aS-(3aalpha,4beta,6aalpha))-N6-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-L-lysine MOD_RES N6-biotinyllysine N6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine N6-biotinyl-L-lysine N6-biotinyllysine N6BtnLys biocytin biotinyl lysyl epsilon-N-biotinyllysine Biotin Biotinylation A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0383 (2S)-2-amino-6-(5-[(3R)-1,2-dithiolan-3-yl]pentanamido)hexanoic acid (2S)-2-amino-6-[(5-[(3R)-1,2-dithiolan-3-yl]pentanoyl)amino]hexanoic acid (2S,6'R)-2-amino-6-(6,8-dithiooctanamido)hexanoic acid 2-amino-6-(5-[1,2-dithiolan-3-yl]-1-oxopentyl)aminohexanoic acid MOD_RES N6-lipoyllysine N-Lipoyl- (on Lysine) N6-6,8-dithiooctanoyllysine N6-lipoyl-L-lysine N6-lipoyllysine N6LipLys lipoylk PSI-MOD Lipoyl MOD:00127 N6-lipoyl-L-lysine MOD:00127 A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine. DeltaMass:0 OMSSA:67 PubMed:3421911 PubMed:3522581 PubMed:7719855 RESID:AA0118 Unimod:42#K DiffAvg: 188.30 DiffFormula: C 8 H 12 N 0 O 1 S 2 DiffMono: 188.032957 Formula: C 14 H 24 N 2 O 2 S 2 MassAvg: 316.48 MassMono: 316.127920 Origin: K Source: natural TermSpec: none Unimod: Unimod:42 (2S)-2-amino-6-(5-[(3R)-1,2-dithiolan-3-yl]pentanamido)hexanoic acid (2S)-2-amino-6-[(5-[(3R)-1,2-dithiolan-3-yl]pentanoyl)amino]hexanoic acid (2S,6'R)-2-amino-6-(6,8-dithiooctanamido)hexanoic acid 2-amino-6-(5-[1,2-dithiolan-3-yl]-1-oxopentyl)aminohexanoic acid MOD_RES N6-lipoyllysine N-Lipoyl- (on Lysine) N6-6,8-dithiooctanoyllysine N6-lipoyl-L-lysine N6-lipoyllysine N6LipLys lipoylk Lipoyl Lipoyl A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0387 (2S)-2-amino-6-[([3-hydroxy-2-methyl-5-phosphonooxymethylpyridin-4-yl]methylidene)amino]hexanoic acid MOD_RES N6-(pyridoxal phosphate)lysine N6-pyridoxal phosphate-L-lysine N6PydoxLys Pyridoxal phosphate (Schiff Base formed to lysine) PSI-MOD Pyridoxal phosphate PyridoxalPhosphate MOD:00128 From DeltaMass: Average Mass: 231 N6-pyridoxal phosphate-L-lysine MOD:00128 A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine. DeltaMass:0 PubMed:1544460 RESID:AA0119 Unimod:46#K DiffAvg: 229.13 DiffFormula: C 8 H 8 N 1 O 5 P 1 DiffMono: 229.014009 Formula: C 14 H 20 N 3 O 6 P 1 MassAvg: 357.30 MassMono: 357.108972 Origin: K Source: natural TermSpec: none Unimod: Unimod:46 (2S)-2-amino-6-[([3-hydroxy-2-methyl-5-phosphonooxymethylpyridin-4-yl]methylidene)amino]hexanoic acid MOD_RES N6-(pyridoxal phosphate)lysine N6-pyridoxal phosphate-L-lysine N6PydoxLys Pyridoxal phosphate (Schiff Base formed to lysine) Pyridoxal phosphate PyridoxalPhosphate A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine, the adduct of retinal. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0388 (2S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid MOD_RES N6-(retinylidene)lysine N6-retinal-L-lysine N6-retinyl-lysine N6-retinylidene-L-lysine N6RetalLys PSI-MOD Retinylidene retinal MOD:00129 N6-retinylidene-L-lysine MOD:00129 A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine, the adduct of retinal. PubMed:6794028 PubMed:6870827 RESID:AA0120 Unimod:380#K DiffAvg: 266.43 DiffFormula: C 20 H 26 N 0 O 0 DiffMono: 266.203451 Formula: C 26 H 38 N 2 O 1 MassAvg: 394.60 MassMono: 394.298414 Origin: K Source: natural TermSpec: none Unimod: Unimod:380 (2S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid MOD_RES N6-(retinylidene)lysine N6-retinal-L-lysine N6-retinyl-lysine N6-retinylidene-L-lysine N6RetalLys Retinylidene retinal A protein modification that effectively converts an L-lysine residue to L-allysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0059 (2S)-2-amino-6-oxohexanoic acid 2-amino-5-formylvaleric acid 2-amino-adipic acid semialdahyde 2-aminoadipate 6-semialdehyde 5-formyl-norvaline 6-oxonorleucine AASA Allysine (from Lysine) L-allysine Lysal MOD_RES Allysine Oxidation of lysine (to aminoadipic semialdehyde) alpha-amino-adipic acid delta-semialdahyde PSI-MOD Lys->Allysine Lysine oxidation to aminoadipic semialdehyde MOD:00130 From DeltaMass: Average Mass: -1 L-allysine MOD:00130 A protein modification that effectively converts an L-lysine residue to L-allysine. ChEBI:17917 DeltaMass:0 PubMed:11120890 PubMed:11332453 PubMed:358196 PubMed:5337886 PubMed:5529814 RESID:AA0121 Unimod:352#K DiffAvg: -1.03 DiffFormula: C 0 H -3 N -1 O 1 DiffMono: -1.031634 Formula: C 6 H 9 N 1 O 2 MassAvg: 127.14 MassMono: 127.063329 Origin: K Source: natural TermSpec: none Unimod: Unimod:352 (2S)-2-amino-6-oxohexanoic acid 2-amino-5-formylvaleric acid 2-amino-adipic acid semialdahyde 2-aminoadipate 6-semialdehyde 5-formyl-norvaline 6-oxonorleucine AASA Allysine (from Lysine) L-allysine Lysal MOD_RES Allysine Oxidation of lysine (to aminoadipic semialdehyde) alpha-amino-adipic acid delta-semialdahyde Lys->Allysine Lysine oxidation to aminoadipic semialdehyde A protein modification that effectively converts an L-lysine residue to L-2-aminoadipic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-aminohexanedioic acid 2-amino-1,4-butanedicarboxylic acid L-2-aminoadipic acid L-alpha-aminoadipic acid Lysoic Oxidation of lysine (to aminoadipic acid) PSI-MOD Lys->AminoadipicAcid alpha-amino adipic acid MOD:00131 From DeltaMass: References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Notes:Expected reaction following oxidation of lysine to aminoadipic semialdehyde. Not proven experimentally but deduced by reference to the similar known reaction of oxidation of Arg to Glu via the semialdehyde. [This has been observed as a natural modification, see RESID:AA0122. JSG] L-2-aminoadipic acid MOD:00131 A protein modification that effectively converts an L-lysine residue to L-2-aminoadipic acid. DeltaMass:353 PubMed:336041 PubMed:358196 PubMed:7419498 RESID:AA0122 Unimod:381#K DiffAvg: 14.97 DiffFormula: C 0 H -3 N -1 O 2 DiffMono: 14.963280 Formula: C 6 H 9 N 1 O 3 MassAvg: 143.14 MassMono: 143.058243 Origin: K Source: natural TermSpec: none Unimod: Unimod:381 (2S)-2-aminohexanedioic acid 2-amino-1,4-butanedicarboxylic acid L-2-aminoadipic acid L-alpha-aminoadipic acid Lysoic Oxidation of lysine (to aminoadipic acid) Lys->AminoadipicAcid alpha-amino adipic acid A protein modification that effectively crosslinks an L-serine residue and an L-lysine residue to release water and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0172 (2R,9S)-lysinoalanine (2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid CROSSLNK Lysinoalanine (Ser-Lys) L-lysinoalanine LAL Lysinoalanine (from Cysteine) N-epsilon-(2-amino-2-carboxyethyl)-L-lysine N6-(2-amino-2-carboxyethyl)-L-lysine XLNK-N6Lys-3Dha(Ser) alaninolysine PSI-MOD MOD:00132 Cross-link 2. This entry is for the crosslink of peptidyl serine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34. L-lysinoalanine (Lys-Ser) MOD:00132 A protein modification that effectively crosslinks an L-serine residue and an L-lysine residue to release water and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid. DeltaMass:0 PubMed:2544544 RESID:AA0123#KSX DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 9 H 15 N 3 O 2 MassAvg: 197.24 MassMono: 197.116427 Origin: K, S Source: natural TermSpec: none (2R,9S)-lysinoalanine (2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid CROSSLNK Lysinoalanine (Ser-Lys) L-lysinoalanine LAL Lysinoalanine (from Cysteine) N-epsilon-(2-amino-2-carboxyethyl)-L-lysine N6-(2-amino-2-carboxyethyl)-L-lysine XLNK-N6Lys-3Dha(Ser) alaninolysine A protein modification that effectively crosslinks an L-glutamine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoglutamyl)-L-lysine and the release of ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0158 (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid 5-glutamyl N6-lysine CROSSLNK Isoglutamyl lysine isopeptide (Lys-Gln) N alpha -(gamma-Glutamyl)-lysine N(epsilon)-(gamma-glutamyl)lysine N6-(L-isoglutamyl)-L-lysine XLNK-N6Lys-5Glu(Gln) PSI-MOD MOD:00133 Cross-link 2. N6-(L-isoglutamyl)-L-lysine (Gln) MOD:00133 A protein modification that effectively crosslinks an L-glutamine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoglutamyl)-L-lysine and the release of ammonia. ChEBI:21863 DeltaMass:0 PubMed:2461365 PubMed:5637041 PubMed:5656070 PubMed:8598899 RESID:AA0124#GLN DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 11 H 17 N 3 O 3 MassAvg: 239.27 MassMono: 239.126991 Origin: K, Q Source: natural TermSpec: none (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid 5-glutamyl N6-lysine CROSSLNK Isoglutamyl lysine isopeptide (Lys-Gln) N alpha -(gamma-Glutamyl)-lysine N(epsilon)-(gamma-glutamyl)lysine N6-(L-isoglutamyl)-L-lysine XLNK-N6Lys-5Glu(Gln) A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0134 (2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid CROSSLNK Glycyl lysine isopeptide (Gly-Lys) (interchain with K-...) CROSSLNK Glycyl lysine isopeptide (Lys-Gly) (interchain with G-...) N6-(glycyl)-L-lysine N6-glycyllysine XLNK-N6Lys-1Gly PSI-MOD MOD:00134 Cross-link 2; this is the common crosslink structure formed by ubiquitin, SUMO, and similar proteins. N6-glycyl-L-lysine MOD:00134 A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine. ChEBI:21885 RESID:AA0125 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 8 H 14 N 3 O 2 MassAvg: 184.22 MassMono: 184.108602 Origin: G, K Source: natural TermSpec: C-term (2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid CROSSLNK Glycyl lysine isopeptide (Gly-Lys) (interchain with K-...) CROSSLNK Glycyl lysine isopeptide (Lys-Gly) (interchain with G-...) N6-(glycyl)-L-lysine N6-glycyllysine XLNK-N6Lys-1Gly A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine and the release of ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0489 (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid 2-amino-N4-(carboxymethyl)-butanediamic acid CROSSLNK Isoaspartyl glycine isopeptide (Asn-Gly) CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asn) N-(L-isoaspartyl)-glycine N-beta-aspartylglycine N4-(carboxymethyl)-asparagine XLNK-4Asp-NGly(Asn) isoaspartyl glycine PSI-MOD MOD:00135 Cross-link 2. N-(L-isoaspartyl)-glycine (Asn) MOD:00135 A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine and the release of ammonia. ChEBI:21479 PubMed:1826288 RESID:AA0126 DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 6 H 7 N 2 O 3 MassAvg: 155.13 MassMono: 155.045667 Origin: G, N Source: natural TermSpec: N-term (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid 2-amino-N4-(carboxymethyl)-butanediamic acid CROSSLNK Isoaspartyl glycine isopeptide (Asn-Gly) CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asn) N-(L-isoaspartyl)-glycine N-beta-aspartylglycine N4-(carboxymethyl)-asparagine XLNK-4Asp-NGly(Asn) isoaspartyl glycine A protein modification that effectively converts an L-cysteine residue to pyruvic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0265 2-oxopropanoic acid MOD_RES Pyruvic acid (Cys) Pyruv(Cys) pyruvic acid PSI-MOD MOD:00136 pyruvic acid (Cys) MOD:00136 A protein modification that effectively converts an L-cysteine residue to pyruvic acid. PubMed:10085076 PubMed:3042771 PubMed:8464063 RESID:AA0127#CYS Unimod:382 DiffAvg: -33.09 DiffFormula: C 0 H -3 N -1 O 1 S -1 DiffMono: -33.003705 Formula: C 3 H 3 O 2 MassAvg: 71.06 MassMono: 71.013304 Origin: C Source: natural TermSpec: N-term Unimod: Unimod:382 2-oxopropanoic acid MOD_RES Pyruvic acid (Cys) Pyruv(Cys) pyruvic acid A protein modification that effectively converts an L-phenylalanine residue into L-3-phenyllactic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: uniprot.ptm:PTM-0035 (2S)-2-hydroxy-3-phenylpropanoic acid L-3-phenyllactic acid MOD_RES 3-phenyllactic acid PSI-MOD Deamidated Deamidation MOD:00137 This modification is not the result of deamidation, instead the alpha amino group is replaced with an hydroxyl group. L-3-phenyllactic acid MOD:00137 A protein modification that effectively converts an L-phenylalanine residue into L-3-phenyllactic acid. PubMed:1973541 RESID:AA0128 Unimod:7#F DiffAvg: 0.98 DiffFormula: C 0 H -1 N -1 O 1 DiffMono: 0.984016 Formula: C 9 H 9 O 2 MassAvg: 149.17 MassMono: 149.060255 Origin: F TermSpec: N-term Unimod: Unimod:7 (2S)-2-hydroxy-3-phenylpropanoic acid L-3-phenyllactic acid MOD_RES 3-phenyllactic acid Deamidated Deamidation A protein modification that effectively converts an L-threonine residue into 2-oxobutanoic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: uniprot.ptm:PTM-0017 2-ketobutyric acid 2-oxobutanoic acid 2-oxobutyric acid MOD_RES 2-oxobutanoic acid PSI-MOD Ammonia-loss Loss of ammonia MOD:00138 2-oxobutanoic acid MOD:00138 A protein modification that effectively converts an L-threonine residue into 2-oxobutanoic acid. ChEBI:149508 PubMed:15023056 PubMed:1680314 PubMed:2253617 PubMed:2764678 RESID:AA0129 Unimod:385#T DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 4 H 5 O 2 MassAvg: 85.08 MassMono: 85.028954 Origin: T TermSpec: N-term Unimod: Unimod:385 2-ketobutyric acid 2-oxobutanoic acid 2-oxobutanoic acid 2-oxobutyric acid MOD_RES 2-oxobutanoic acid Ammonia-loss Loss of ammonia A protein modification that effectively converts an L-tryptophan residue to N2-succinyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0181 (2S)-2-(3-carboxypropanoyl)amino-3-(1H-indol-3-yl)propanoic acid (2S)-2-amino-(6,7-dihydro-6,7-dioxo-1H-indole)-3-propanoic acid MOD_RES N2-succinyltryptophan N2-succinyl-L-tryptophan PSI-MOD Succinic anhydride labeling reagent light form (N-term) Succinyl MOD:00139 N2-succinyl-L-tryptophan MOD:00139 A protein modification that effectively converts an L-tryptophan residue to N2-succinyl-L-tryptophan. PubMed:11857757 PubMed:12175151 PubMed:8471040 RESID:AA0130 Unimod:64#N-term DiffAvg: 100.07 DiffFormula: C 4 H 4 N 0 O 3 DiffMono: 100.016044 Formula: C 15 H 15 N 2 O 4 MassAvg: 287.29 MassMono: 287.103182 Origin: W Source: natural TermSpec: N-term Unimod: Unimod:64 (2S)-2-(3-carboxypropanoyl)amino-3-(1H-indol-3-yl)propanoic acid (2S)-2-amino-(6,7-dihydro-6,7-dioxo-1H-indole)-3-propanoic acid MOD_RES N2-succinyltryptophan N2-succinyl-L-tryptophan Succinic anhydride labeling reagent light form (N-term) Succinyl A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycocyanobilin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-ethyl-1,2,3,19,21,22,24-heptahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione BINDING Phycocyanobilin chromophore (covalent; via 1 link) PCB S-Phycocyanobilin (on Cysteine) S-phycocyanobilin-L-cysteine phycobilin cysteine phycocyanobilin cysteine adduct PSI-MOD Phycocyanobilin phycocyanobilin MOD:00140 From DeltaMass: Average Mass: 587. S-phycocyanobilin-L-cysteine MOD:00140 A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycocyanobilin. ChEBI:15617 DeltaMass:0 PubMed:16644722 PubMed:3208761 PubMed:3838747 PubMed:7918400 RESID:AA0131 Unimod:387#C DiffAvg: 586.69 DiffFormula: C 33 H 38 N 4 O 6 S 0 DiffMono: 586.279135 Formula: C 36 H 43 N 5 O 7 S 1 MassAvg: 689.83 MassMono: 689.288320 Origin: C Source: natural TermSpec: none Unimod: Unimod:387 (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-ethyl-1,2,3,19,21,22,24-heptahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione BINDING Phycocyanobilin chromophore (covalent; via 1 link) PCB S-Phycocyanobilin (on Cysteine) S-phycocyanobilin-L-cysteine phycobilin cysteine phycocyanobilin cysteine adduct Phycocyanobilin phycocyanobilin A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoerythrobilin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S,3R,16R)-18-ethenyl-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid BINDING Phycoerythrobilin chromophore (covalent; via 1 link) PEB S-phycoerythrobilin-L-cysteine phycoerythrobilin cysteine adduct PSI-MOD Phycoerythrobilin phycoerythrobilin MOD:00141 S-phycoerythrobilin-L-cysteine MOD:00141 A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoerythrobilin. ChEBI:15618 PubMed:14588022 PubMed:3208761 PubMed:3838747 PubMed:8876649 RESID:AA0132 Unimod:388#C DiffAvg: 588.70 DiffFormula: C 33 H 40 N 4 O 6 S 0 DiffMono: 588.294785 Formula: C 36 H 45 N 5 O 7 S 1 MassAvg: 691.84 MassMono: 691.303970 Origin: C Source: natural TermSpec: none Unimod: Unimod:388 (2S,3R,16R)-18-ethenyl-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid BINDING Phycoerythrobilin chromophore (covalent; via 1 link) PEB S-phycoerythrobilin-L-cysteine phycoerythrobilin cysteine adduct Phycoerythrobilin phycoerythrobilin A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phytochromobilin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid BINDING Phytochromobilin chromophore (covalent; via 1 link) S-phytochromobilin-L-cysteine phytochrome chromophore phytochromobilin cysteine adduct PSI-MOD Phytochromobilin phytochromobilin MOD:00142 S-phytochromobilin-L-cysteine MOD:00142 A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phytochromobilin. ChEBI:15619 PubMed:1634523 PubMed:16593380 PubMed:3208761 PubMed:7918400 RESID:AA0133 Unimod:389#C DiffAvg: 584.67 DiffFormula: C 33 H 36 N 4 O 6 S 0 DiffMono: 584.263485 Formula: C 36 H 41 N 5 O 7 S 1 MassAvg: 687.81 MassMono: 687.272670 Origin: C Source: natural TermSpec: none Unimod: Unimod:389 (2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione 18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid BINDING Phytochromobilin chromophore (covalent; via 1 link) S-phytochromobilin-L-cysteine phytochrome chromophore phytochromobilin cysteine adduct Phytochromobilin phytochromobilin A protein modification that effectively results from forming an adduct between two cysteine residues and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (7,12-bis[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate 2,4-bis[1-(S-cysteinyl)ethyl]protoporphyrin IX BINDING Heme (covalent) HemeCys2 biscysteinyl heme heme-bis-L-cysteine PSI-MOD MOD:00143 Cross-link 2. heme-bis-L-cysteine MOD:00143 A protein modification that effectively results from forming an adduct between two cysteine residues and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. ChEBI:17627 PubMed:5545094 PubMed:8827449 RESID:AA0134 DiffAvg: 616.50 DiffFormula: C 34 Fe 1 H 32 N 4 O 4 S 0 DiffMono: 616.177293 Formula: C 40 Fe 1 H 42 N 6 O 6 S 2 MassAvg: 822.78 MassMono: 822.195663 Origin: C, C Source: natural TermSpec: none (7,12-bis[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate 2,4-bis[1-(S-cysteinyl)ethyl]protoporphyrin IX BINDING Heme (covalent) HemeCys2 biscysteinyl heme heme-bis-L-cysteine A protein modification that effectively results from forming an adduct between a cysteine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (12-ethenyl-7-[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate 4-[1-(S-cysteinyl)ethyl]protoporphyrin IX BINDING Heme (covalent; via 1 link) HemeCys1 S-Heme (on Cysteine) cysteinyl heme heme-L-cysteine PSI-MOD Heme heme MOD:00144 From DeltaMass: Average Mass: 617. heme-L-cysteine MOD:00144 A protein modification that effectively results from forming an adduct between a cysteine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. ChEBI:17627 DeltaMass:0 PubMed:170910 PubMed:192772 PubMed:2536325 PubMed:9535866 RESID:AA0135 Unimod:390#C DiffAvg: 616.50 DiffFormula: C 34 Fe 1 H 32 N 4 O 4 S 0 DiffMono: 616.177293 Formula: C 37 Fe 1 H 37 N 5 O 5 S 1 MassAvg: 719.64 MassMono: 719.186478 Origin: C Source: natural TermSpec: none Unimod: Unimod:390 (12-ethenyl-7-[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate 4-[1-(S-cysteinyl)ethyl]protoporphyrin IX BINDING Heme (covalent; via 1 link) HemeCys1 S-Heme (on Cysteine) cysteinyl heme heme-L-cysteine Heme heme A protein modification that effectively converts four L-cysteine residues iron atom to tetrakis-L-cysteinyl iron. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron tetrakis(cysteinato-kappaS)-iron tetrakis-L-cysteinyl iron PSI-MOD MOD:00145 Cross-link 4. tetrakis-L-cysteinyl iron MOD:00145 A protein modification that effectively converts four L-cysteine residues iron atom to tetrakis-L-cysteinyl iron. PubMed:1303768 PubMed:2244884 RESID:AA0136 DiffAvg: 51.81 DiffFormula: C 0 Fe 1 H -4 N 0 O 0 S 0 DiffMono: 51.904735 FormalCharge: 2- Formula: C 12 Fe 1 H 16 N 4 O 4 S 4 MassAvg: 464.37 MassMono: 463.941474 Origin: C, C, C, C Source: natural TermSpec: none METAL Iron tetrakis(cysteinato-kappaS)-iron tetrakis-L-cysteinyl iron A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to tetrakis-L-cysteinyl diiron disulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (2Fe-2S) METAL Iron-sulfur (2Fe-2S); shared with dimeric partner tetrakis-L-cysteinyl diiron disulfide tetrakiscysteinato-1kappa(2)S,2kappa(2)S-di-mu-sulfido-diiron PSI-MOD MOD:00146 Cross-link 4. tetrakis-L-cysteinyl diiron disulfide MOD:00146 A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to tetrakis-L-cysteinyl diiron disulfide. PubMed:2123937 PubMed:6801028 PubMed:7763242 PubMed:8688437 RESID:AA0137 DiffAvg: 171.78 DiffFormula: C 0 Fe 2 H -4 N 0 O 0 S 2 DiffMono: 171.783814 FormalCharge: 2- Formula: C 12 Fe 2 H 16 N 4 O 4 S 6 MassAvg: 584.34 MassMono: 583.820553 Origin: C, C, C, C Source: natural TermSpec: none METAL Iron-sulfur (2Fe-2S) METAL Iron-sulfur (2Fe-2S); shared with dimeric partner tetrakis-L-cysteinyl diiron disulfide tetrakiscysteinato-1kappa(2)S,2kappa(2)S-di-mu-sulfido-diiron A protein modification that effectively converts six L-cysteine residues and a three-iron three-sulfur cluster to hexakis-L-cysteinyl triiron trisulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: hexakis-L-cysteinyl triiron trisulfide tri-mu-sulfido-hexakiscysteinato-1kappa(2)S,2kappa(2)S,3kappa(2)S-triiron tri-mu-sulfidotris(biscysteinato-kappaS-iron) PSI-MOD MOD:00147 Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. hexakis-L-cysteinyl triiron trisulfide MOD:00147 A protein modification that effectively converts six L-cysteine residues and a three-iron three-sulfur cluster to hexakis-L-cysteinyl triiron trisulfide. PubMed:3379067 PubMed:3932661 PubMed:7354058 RESID:AA0138 DiffAvg: 257.67 DiffFormula: C 0 Fe 3 H -6 N 0 O 0 S 3 DiffMono: 257.675721 FormalCharge: 3- Formula: C 18 Fe 3 H 24 N 6 O 6 S 9 MassAvg: 876.50 MassMono: 875.730830 Origin: C, C, C, C, C, C Source: hypothetical TermSpec: none hexakis-L-cysteinyl triiron trisulfide tri-mu-sulfido-hexakiscysteinato-1kappa(2)S,2kappa(2)S,3kappa(2)S-triiron tri-mu-sulfidotris(biscysteinato-kappaS-iron) A protein modification that effectively converts three L-cysteine residues and a three-iron four-sulfur cluster to tris-L-cysteinyl triiron tetrasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (3Fe-4S) mu3-sulfido tri-mu-sulfido tris-S-L-cysteinyl triiron mu3-sulfido-tri-mu-sulfido-triscysteinato-1kappaS,2kappaS,3kappaS-triiron tris-L-cysteinyl triiron tetrasulfide tris-L-cysteinyl triiron tetrasulfide C3 cluster tris-L-cysteinyl triiron tetrasulfide cubane form tris-L-cysteinyl triiron tetrasulfide cuboid cluster tris-L-cysteinyl triiron tetrasulfide trigonal cluster PSI-MOD MOD:00148 Cross-link 3. tris-L-cysteinyl triiron tetrasulfide MOD:00148 A protein modification that effectively converts three L-cysteine residues and a three-iron four-sulfur cluster to tris-L-cysteinyl triiron tetrasulfide. PubMed:10555576 PubMed:2056535 PubMed:3422475 PubMed:6848518 PubMed:7819255 PubMed:9063899 RESID:AA0139 DiffAvg: 292.75 DiffFormula: C 0 Fe 3 H -3 N 0 O 0 S 4 DiffMono: 292.671267 FormalCharge: 3- Formula: C 9 Fe 3 H 12 N 3 O 3 S 7 MassAvg: 602.17 MassMono: 601.698821 Origin: C, C, C Source: natural TermSpec: none METAL Iron-sulfur (3Fe-4S) mu3-sulfido tri-mu-sulfido tris-S-L-cysteinyl triiron mu3-sulfido-tri-mu-sulfido-triscysteinato-1kappaS,2kappaS,3kappaS-triiron tris-L-cysteinyl triiron tetrasulfide tris-L-cysteinyl triiron tetrasulfide C3 cluster tris-L-cysteinyl triiron tetrasulfide cubane form tris-L-cysteinyl triiron tetrasulfide cuboid cluster tris-L-cysteinyl triiron tetrasulfide trigonal cluster A protein modification that effectively converts four L-cysteine residues and a four-iron four-sulfur cluster to tetrakis-L-cysteinyl tetrairon tetrasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (4Fe-4S) METAL Iron-sulfur (4Fe-4S); shared with dimeric partner tetra-mu3-sulfido-tetrakis(cysteinato)-1kappaS,2kappaS,3kappaS,4kappaS-tetrahedro-tetrairon tetra-mu3-sulfidotetrakis(S-cysteinyliron) tetrakis-L-cysteinyl tetrairon tetrasulfide PSI-MOD MOD:00149 Cross-link 4. tetrakis-L-cysteinyl tetrairon tetrasulfide MOD:00149 A protein modification that effectively converts four L-cysteine residues and a four-iron four-sulfur cluster to tetrakis-L-cysteinyl tetrairon tetrasulfide. PubMed:3351918 PubMed:7803404 PubMed:7819196 PubMed:932007 RESID:AA0140 DiffAvg: 347.59 DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono: 347.597831 FormalCharge: 2- Formula: C 12 Fe 4 H 16 N 4 O 4 S 8 MassAvg: 760.15 MassMono: 759.634570 Origin: C, C, C, C Source: natural TermSpec: none METAL Iron-sulfur (4Fe-4S) METAL Iron-sulfur (4Fe-4S); shared with dimeric partner tetra-mu3-sulfido-tetrakis(cysteinato)-1kappaS,2kappaS,3kappaS,4kappaS-tetrahedro-tetrairon tetra-mu3-sulfidotetrakis(S-cysteinyliron) tetrakis-L-cysteinyl tetrairon tetrasulfide A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-molybdenum seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide carbide cysteinato-8kappaS-histidino-1kappaN(tau)-[(2R)-4-carboxy-2-(carboxymethyl)-2-oxidobutanoate-1kappaO(1),1kappaO(2)]-mu6-carbido-2:3:4:5:6:7kappa(6)C-hexa-mu3-sulfido-1:2:3kappa(3)S;1:2:4kappa(3)S;1:3:4kappa(3)S;5:6:8kappa(3)S;5:7:8kappa(3)S;6:7:8kappa(3)S-tri-mu2-sulfido-2:5kappa(2)S;3:6kappa(2)S;4:7kappa(2)S molybdenum heptairon nitrogenase iron-molybdenum cofactor PSI-MOD MOD:00150 Cross-link 2; incidental to RESID:AA0300. L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide MOD:00150 A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-molybdenum seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide. PubMed:10525412 PubMed:12215645 PubMed:12733878 PubMed:1529354 PubMed:8027059 RESID:AA0141 DiffAvg: 991.53 DiffFormula: C 7 Fe 7 H 6 Mo 1 N 1 O 7 S 9 DiffMono: 993.213036 Formula: C 16 Fe 7 H 18 Mo 1 N 5 O 9 S 10 MassAvg: 1231.81 MassMono: 1233.281133 Origin: C, H Source: natural TermSpec: none L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide carbide cysteinato-8kappaS-histidino-1kappaN(tau)-[(2R)-4-carboxy-2-(carboxymethyl)-2-oxidobutanoate-1kappaO(1),1kappaO(2)]-mu6-carbido-2:3:4:5:6:7kappa(6)C-hexa-mu3-sulfido-1:2:3kappa(3)S;1:2:4kappa(3)S;1:3:4kappa(3)S;5:6:8kappa(3)S;5:7:8kappa(3)S;6:7:8kappa(3)S-tri-mu2-sulfido-2:5kappa(2)S;3:6kappa(2)S;4:7kappa(2)S molybdenum heptairon nitrogenase iron-molybdenum cofactor A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdopterin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4R,5aR,11aR)-8-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-4,5a,6,9,10,11,11a-heptahydro-4-(phosphoric acid)methyl-2,2,10-trioxo-pteridino[6,7-5,6]pyrano[3,4-4,3][1,2,5]molybdadithiolene L-cysteinyl molybdopterin METAL Molybdenum-pterin MoPterCys cysteinyl Mo-molybdopterin cysteinyl Mo-pterin molybdoenzyme molybdenum cofactor PSI-MOD Molybdopterin molybdopterin MOD:00151 L-cysteinyl molybdopterin MOD:00151 A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdopterin. PubMed:14527393 PubMed:7878465 PubMed:9428520 RESID:AA0142 Unimod:391#C DiffAvg: 520.27 DiffFormula: C 10 H 11 Mo 1 N 5 O 8 P 1 S 2 DiffMono: 521.884074 Formula: C 13 H 16 Mo 1 N 6 O 9 P 1 S 3 MassAvg: 623.41 MassMono: 624.893259 Origin: C Source: natural TermSpec: none Unimod: Unimod:391 (4R,5aR,11aR)-8-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-4,5a,6,9,10,11,11a-heptahydro-4-(phosphoric acid)methyl-2,2,10-trioxo-pteridino[6,7-5,6]pyrano[3,4-4,3][1,2,5]molybdadithiolene L-cysteinyl molybdopterin METAL Molybdenum-pterin MoPterCys cysteinyl Mo-molybdopterin cysteinyl Mo-pterin molybdoenzyme molybdenum cofactor Molybdopterin molybdopterin A protein modification that effectively converts an L-cysteine residue to S'-(8alpha-FAD)-L-cystine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0272 (2R)-2-amino-3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]sulfanylpropanoic acid 8alpha-(S-cysteinyl)FAD MOD_RES S-8alpha-FAD cysteine S-(8alpha-FAD)-L-cysteine S8aFADCys PSI-MOD FAD Flavin adenine dinucleotide MOD:00152 S-(8alpha-FAD)-L-cysteine MOD:00152 A protein modification that effectively converts an L-cysteine residue to S'-(8alpha-FAD)-L-cystine. PubMed:10220347 RESID:AA0143 Unimod:50#C DiffAvg: 783.54 DiffFormula: C 27 H 31 N 9 O 15 P 2 S 0 DiffMono: 783.141485 Formula: C 30 H 36 N 10 O 16 P 2 S 1 MassAvg: 886.68 MassMono: 886.150669 Origin: C Source: natural TermSpec: none Unimod: Unimod:50 (2R)-2-amino-3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]sulfanylpropanoic acid 8alpha-(S-cysteinyl)FAD MOD_RES S-8alpha-FAD cysteine S-(8alpha-FAD)-L-cysteine S8aFADCys FAD Flavin adenine dinucleotide A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FAD)-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0258 (2S)-2-amino-3-(3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid 3'-(8alpha-FAD)-L-histidine 8alpha-(N(delta)-histidyl)FAD 8alpha-(N3'-histidyl)FAD MOD_RES Pros-8alpha-FAD histidine N(pi)-(8alpha-FAD)-histidine Np8aFADHis pros-(8alpha-FAD)-histidine PSI-MOD 8alpha-N1-histidyl FAD FAD Flavin adenine dinucleotide MOD:00153 3'-(8alpha-FAD)-L-histidine MOD:00153 A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FAD)-L-histidine. PubMed:241294 PubMed:8076 RESID:AA0144 Unimod:50#H DiffAvg: 783.54 DiffFormula: C 27 H 31 N 9 O 15 P 2 DiffMono: 783.141485 Formula: C 33 H 38 N 12 O 16 P 2 MassAvg: 920.68 MassMono: 920.200396 Origin: H Source: natural TermSpec: none Unimod: Unimod:50 (2S)-2-amino-3-(3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid 3'-(8alpha-FAD)-L-histidine 8alpha-(N(delta)-histidyl)FAD 8alpha-(N3'-histidyl)FAD MOD_RES Pros-8alpha-FAD histidine N(pi)-(8alpha-FAD)-histidine Np8aFADHis pros-(8alpha-FAD)-histidine 8alpha-N1-histidyl FAD FAD Flavin adenine dinucleotide A protein modification that effectively converts an L-tyrosine residue to O4'-(8alpha-FAD)-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0231 (2S)-2-amino-3-(4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxyphenyl)propanoic acid 8alpha-(O4'-tyrosyl)FAD MOD_RES O-8alpha-FAD tyrosine O-8 alpha-Flavin [FAD])- (of Tyrosine) O4'-(8alpha-FAD)-L-tyrosine O8aFADTyr PSI-MOD FAD Flavin adenine dinucleotide MOD:00154 From DeltaMass: Average Mass: 783 O4'-(8alpha-FAD)-L-tyrosine MOD:00154 A protein modification that effectively converts an L-tyrosine residue to O4'-(8alpha-FAD)-L-tyrosine. DeltaMass:0 PubMed:7391034 RESID:AA0145 Unimod:50#Y DiffAvg: 783.54 DiffFormula: C 27 H 31 N 9 O 15 P 2 DiffMono: 783.141485 Formula: C 36 H 40 N 10 O 17 P 2 MassAvg: 946.72 MassMono: 946.204813 Origin: Y Source: natural TermSpec: none Unimod: Unimod:50 (2S)-2-amino-3-(4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxyphenyl)propanoic acid 8alpha-(O4'-tyrosyl)FAD MOD_RES O-8alpha-FAD tyrosine O-8 alpha-Flavin [FAD])- (of Tyrosine) O4'-(8alpha-FAD)-L-tyrosine O8aFADTyr FAD Flavin adenine dinucleotide A protein modification that effectively converts an L-tyrosine residue to L-3',4'-dihydroxyphenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0023 (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid 3,4-Dihydroxy-Phenylalanine (from Tyrosine) (DOPA) 3HyTyr L-3',4'-dihydroxyphenylalanine L-3'-hydroxytyrosine L-DOPA MOD_RES 3',4'-dihydroxyphenylalanine hydroxylationy levodopa mod194 PSI-MOD MOD:00155 incidental to RESID:AA0368 From DeltaMass: Average Mass: 16 L-3',4'-dihydroxyphenylalanine MOD:00155 A protein modification that effectively converts an L-tyrosine residue to L-3',4'-dihydroxyphenylalanine. ChEBI:141815 DeltaMass:0 OMSSA:194 OMSSA:64 PubMed:1610822 PubMed:1903612 PubMed:3734192 RESID:AA0146 Unimod:35#Y DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 9 H 9 N 1 O 3 MassAvg: 179.18 MassMono: 179.058243 Origin: Y Source: natural TermSpec: none Unimod: Unimod:35 (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid 3,4-Dihydroxy-Phenylalanine (from Tyrosine) (DOPA) 3HyTyr L-3',4'-dihydroxyphenylalanine L-3'-hydroxytyrosine L-DOPA MOD_RES 3',4'-dihydroxyphenylalanine hydroxylationy levodopa mod194 A protein modification that effectively converts an L-tyrosine residue to an L-2',4',5'-topaquinone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0009 (2S)-2-amino-3-(5-hydroxy-2,5-cyclohexadien-1,4-dion-2-yl)propanoic acid 2,4,5-trihydroxyphenylalanine quinone 5-(2-carboxy-2-aminoethyl)-2-hydroxy-1,4-benzoquinone L-2',4',5'-topaquinone L-2,4,5-TOPAquinone MOD_RES 2',4',5'-topaquinone TPQ TopaQ PSI-MOD Quinone quinone MOD:00156 L-2',4',5'-topaquinone MOD:00156 A protein modification that effectively converts an L-tyrosine residue to an L-2',4',5'-topaquinone. ChEBI:21187 PubMed:10387067 PubMed:1457410 PubMed:1569055 PubMed:2111581 RESID:AA0147 Unimod:392#Y DiffAvg: 29.98 DiffFormula: C 0 H -2 N 0 O 2 DiffMono: 29.974179 Formula: C 9 H 7 N 1 O 4 MassAvg: 193.16 MassMono: 193.037508 Origin: Y Source: natural TermSpec: none Unimod: Unimod:392 (2S)-2-amino-3-(5-hydroxy-2,5-cyclohexadien-1,4-dion-2-yl)propanoic acid 2,4,5-trihydroxyphenylalanine quinone 5-(2-carboxy-2-aminoethyl)-2-hydroxy-1,4-benzoquinone L-2',4',5'-topaquinone L-2,4,5-TOPAquinone MOD_RES 2',4',5'-topaquinone TPQ TopaQ Quinone quinone A protein modification that effectively converts an L-tryptophan residue to an L-tryptophan quinone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0299 (2S)-2-amino-3-(6,7-dioxo-1H-indol-3-yl)propanoic acid 2-amino-3-(6,7-dioxo-6,7-dihydro-1H-indol-3-yl)-propionic acid 3-[(2S)-2-amino-2-carboxyethyl]-6,7-indolinedione 6,7 Dione (from Tryptophan) L-tryptophyl quinone MOD_RES Tryptophylquinone N-(3-carboxy-1-oxopropyl)-L-tryptophan TrpQ PSI-MOD Quinone quinone MOD:00157 incidental to RESID:AA0149; incidental to RESID:AA0313; From DeltaMass: Average Mass: 30. L-tryptophyl quinone MOD:00157 A protein modification that effectively converts an L-tryptophan residue to an L-tryptophan quinone. DeltaMass:0 PubMed:2028257 RESID:AA0148 Unimod:392#W DiffAvg: 29.98 DiffFormula: C 0 H -2 N 0 O 2 DiffMono: 29.974179 Formula: C 11 H 8 N 2 O 3 MassAvg: 216.20 MassMono: 216.053492 Origin: W Source: natural TermSpec: none Unimod: Unimod:392 (2S)-2-amino-3-(6,7-dioxo-1H-indol-3-yl)propanoic acid 2-amino-3-(6,7-dioxo-6,7-dihydro-1H-indol-3-yl)-propionic acid 3-[(2S)-2-amino-2-carboxyethyl]-6,7-indolinedione 6,7 Dione (from Tryptophan) L-tryptophyl quinone MOD_RES Tryptophylquinone N-(3-carboxy-1-oxopropyl)-L-tryptophan TrpQ Quinone quinone A protein modification that effectively cross-links two L-tryptophan residues by a carbon-carbon bond to form 4'-(L-tryptophan)-L-tryptophyl quinone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0298 2,4-BisTrp-6,7-dione (from Tryptophan) 2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-6,7-dioxo-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid 3-[(2S)-2-amino-2-carboxyethyl]-4-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-6,7-indolinedione 4'-tryptophan-tryptophylquinone 4-(2'-tryptophyl)tryptophan-6,7-dione 4-(L-tryptophan-2-yl)-L-tryptophyl quinone CROSSLNK Tryptophan tryptophylquinone (Trp-Trp) TTQ XLNK-4'Trp-TrpQ alpha,alpha'-diamino-6',7'-dihydro-6',7'-dioxo-(2,4'-bi-1H-indole)-3,3'-dipropanoic acid PSI-MOD MOD:00158 Cross-link 2; secondary to RESID:AA0148; From DeltaMass: Average Mass: 28. 4'-(L-tryptophan)-L-tryptophyl quinone MOD:00158 A protein modification that effectively cross-links two L-tryptophan residues by a carbon-carbon bond to form 4'-(L-tryptophan)-L-tryptophyl quinone. ChEBI:20251 DeltaMass:0 PubMed:2028257 RESID:AA0149 DiffAvg: 27.97 DiffFormula: C 0 H -4 N 0 O 2 DiffMono: 27.958529 Formula: C 22 H 16 N 4 O 4 MassAvg: 400.39 MassMono: 400.117155 Origin: W, W Source: natural TermSpec: none 2,4-BisTrp-6,7-dione (from Tryptophan) 2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-6,7-dioxo-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid 3-[(2S)-2-amino-2-carboxyethyl]-4-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-6,7-indolinedione 4'-tryptophan-tryptophylquinone 4-(2'-tryptophyl)tryptophan-6,7-dione 4-(L-tryptophan-2-yl)-L-tryptophyl quinone CROSSLNK Tryptophan tryptophylquinone (Trp-Trp) TTQ XLNK-4'Trp-TrpQ alpha,alpha'-diamino-6',7'-dihydro-6',7'-dioxo-(2,4'-bi-1H-indole)-3,3'-dipropanoic acid A protein modification that effectively converts an L-serine residue to O-phosphopantetheine-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0391 (2R)-2-hydroxy-3,3-dimethyl-4-[(2S)-2-amino-2-carboxyethyl]phosphonato-N-(3-oxo-3-[(2-sulfanylethyl)amino]propyl)butanamide 4'-Phosphopantetheine MOD_RES O-(pantetheine 4'-phosphoryl)serine O-phosphopantetheine-L-serine OPpantSer PSI-MOD Phosphopantetheine MOD:00159 Unimod has DiffFormula C 11 H 20 N 2 O 6 P 1 S 1 From DeltaMass: Average Mass: 339 O-phosphopantetheine-L-serine MOD:00159 A protein modification that effectively converts an L-serine residue to O-phosphopantetheine-L-serine. DeltaMass:0 PubMed:10320345 PubMed:10997907 PubMed:12057197 PubMed:12869567 PubMed:4568609 RESID:AA0150 Unimod:49#S DiffAvg: 340.33 DiffFormula: C 11 H 21 N 2 O 6 P 1 S 1 DiffMono: 340.085794 Formula: C 14 H 26 N 3 O 8 P 1 S 1 MassAvg: 427.41 MassMono: 427.117822 Origin: S Source: natural TermSpec: none Unimod: Unimod:49 (2R)-2-hydroxy-3,3-dimethyl-4-[(2S)-2-amino-2-carboxyethyl]phosphonato-N-(3-oxo-3-[(2-sulfanylethyl)amino]propyl)butanamide 4'-Phosphopantetheine MOD_RES O-(pantetheine 4'-phosphoryl)serine O-phosphopantetheine-L-serine OPpantSer Phosphopantetheine Phosphopantetheine A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine. Origin: Source: TermSpec: N4GlycoAsn PSI-MOD MOD:00160 N4-glycosyl-L-asparagine MOD:00160 A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine. PubMed:111247 PubMed:1694179 PubMed:5490222 RESID:AA0151#var Origin: N Source: natural TermSpec: none N4GlycoAsn A protein modification that effectively converts an L-cysteine residue to S-glucosylated L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0626 (2R)-2-amino-3-[(beta-D-glucopyranosyl)sulfanyl]propanoic acid CARBOHYD S-linked (Glc) cysteine S-(beta-D-glucopyranosyl)cysteine S-glucosyl-L-cysteine S-glycosyl-cysteine SGlcCys PSI-MOD Hex Hexose MOD:00161 S-glucosyl-L-cysteine MOD:00161 A protein modification that effectively converts an L-cysteine residue to S-glucosylated L-cysteine. PubMed:1145128 PubMed:15279557 PubMed:5286858 RESID:AA0152 Unimod:41#C DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 S 0 DiffMono: 162.052823 Formula: C 9 H 15 N 1 O 6 S 1 MassAvg: 265.28 MassMono: 265.062008 Origin: C Source: natural TermSpec: none Unimod: Unimod:41 (2R)-2-amino-3-[(beta-D-glucopyranosyl)sulfanyl]propanoic acid CARBOHYD S-linked (Glc) cysteine S-(beta-D-glucopyranosyl)cysteine S-glucosyl-L-cysteine S-glycosyl-cysteine SGlcCys Hex Hexose A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S,5R)-2,6-diamino-5-[2-O-(alpha-D-glucopyranosyl)-beta-D-galactopyranosyloxy]hexanoic acid 5-(2-O-alpha-D-glucopyranosyl-beta-D-galactopyranosyl)oxy-L-lysine O5-glucosylgalactosyl-L-hydroxylysine OGlcGal5HyLys PSI-MOD Glucosylgalactosyl glucosylgalactosyl hydroxylysine MOD:00162 Secondary to RESID:AA0028. O5-glucosylgalactosyl-L-hydroxylysine MOD:00162 A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine. PubMed:15149698 PubMed:4288358 PubMed:4319110 RESID:AA0153 Unimod:393 DiffAvg: 340.28 DiffFormula: C 12 H 20 N 0 O 11 DiffMono: 340.100561 Formula: C 18 H 32 N 2 O 12 MassAvg: 468.46 MassMono: 468.195524 Origin: K Source: natural TermSpec: none Unimod: Unimod:393 (2S,5R)-2,6-diamino-5-[2-O-(alpha-D-glucopyranosyl)-beta-D-galactopyranosyloxy]hexanoic acid 5-(2-O-alpha-D-glucopyranosyl-beta-D-galactopyranosyl)oxy-L-lysine O5-glucosylgalactosyl-L-hydroxylysine OGlcGal5HyLys Glucosylgalactosyl glucosylgalactosyl hydroxylysine A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0564 (2S)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)propanoic acid CARBOHYD O-linked (GalNAc) serine O-(N-acetylamino)galactosyl-L-serine O3-(N-acetylgalactosaminyl)serine OGalNAcSer mucin type O-glycosylserine PSI-MOD HexNAc MOD:00163 O-(N-acetylamino)galactosyl-L-serine MOD:00163 A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine. PubMed:115869 PubMed:16005634 PubMed:3086323 PubMed:8948436 PubMed:9092502 RESID:AA0154 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 11 H 18 N 2 O 7 MassAvg: 290.27 MassMono: 290.111401 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)propanoic acid CARBOHYD O-linked (GalNAc) serine O-(N-acetylamino)galactosyl-L-serine O3-(N-acetylgalactosaminyl)serine OGalNAcSer mucin type O-glycosylserine HexNAc A protein modification that effectively converts an L-asparagine residue to O-(N-acetylaminogalactosyl)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0567 (2S,3R)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)butanoic acid CARBOHYD O-linked (GalNAc) threonine CARBOHYD O-linked (HexNAc) O-(N-acetylamino)galactosyl-L-threonine O3-(N-acetylgalactosaminyl)threonine OGalNAcThr mucin type O-glycosylthreonine PSI-MOD HexNAc MOD:00164 O-(N-acetylamino)galactosyl-L-threonine MOD:00164 A protein modification that effectively converts an L-asparagine residue to O-(N-acetylaminogalactosyl)-L-threonine. PubMed:16005634 PubMed:1997327 PubMed:3086323 PubMed:8948436 PubMed:9092502 RESID:AA0155 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 12 H 20 N 2 O 7 MassAvg: 304.30 MassMono: 304.127051 Origin: T Source: natural TermSpec: none (2S,3R)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)butanoic acid CARBOHYD O-linked (GalNAc) threonine CARBOHYD O-linked (HexNAc) O-(N-acetylamino)galactosyl-L-threonine O3-(N-acetylgalactosaminyl)threonine OGalNAcThr mucin type O-glycosylthreonine HexNAc A protein modification that effectively converts an L-tryptophan residue to 1'-mannosyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0535 (2S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid 1'-glycosyl-L-tryptophan 1'-mannosyl-L-tryptophan CARBOHYD N-linked (Man) tryptophan N-mannosyl-tryptophan N1'ManTrp N1-mannosyl-tryptophan PSI-MOD MOD:00165 1'-mannosyl-L-tryptophan MOD:00165 A protein modification that effectively converts an L-tryptophan residue to 1'-mannosyl-L-tryptophan. PubMed:1482345 PubMed:16150691 RESID:AA0156 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 17 H 20 N 2 O 6 MassAvg: 348.36 MassMono: 348.132136 Origin: W Source: natural TermSpec: none (2S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid 1'-glycosyl-L-tryptophan 1'-mannosyl-L-tryptophan CARBOHYD N-linked (Man) tryptophan N-mannosyl-tryptophan N1'ManTrp N1-mannosyl-tryptophan A protein modification that effectively converts an L-tyrosine residue to O4'-glucosyl-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0575 (2S)-2-amino-3-(4-alpha-D-glucopyranosyloxy)phenylpropanoic acid CARBOHYD O-linked (Glc) tyrosine O4'-glucosyl-L-tyrosine O4'-glycosyl-L-tyrosine O4GlcTyr PSI-MOD Hex Hexose MOD:00166 O4'-glucosyl-L-tyrosine MOD:00166 A protein modification that effectively converts an L-tyrosine residue to O4'-glucosyl-tyrosine. PubMed:15279557 PubMed:3181138 RESID:AA0157 Unimod:41#Y DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 15 H 19 N 1 O 7 MassAvg: 325.32 MassMono: 325.116152 Origin: Y Source: natural TermSpec: none Unimod: Unimod:41 (2S)-2-amino-3-(4-alpha-D-glucopyranosyloxy)phenylpropanoic acid CARBOHYD O-linked (Glc) tyrosine O4'-glucosyl-L-tyrosine O4'-glycosyl-L-tyrosine O4GlcTyr Hex Hexose A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylphosphatidylinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0137 GPIAsn LIPID GPI-anchor amidated asparagine N-asparaginyl-glycosylphosphatidylinositolethanolamine PSI-MOD MOD:00167 N-asparaginyl-glycosylphosphatidylinositolethanolamine MOD:00167 A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylphosphatidylinositolethanolamine. PubMed:1824714 PubMed:8276756 RESID:AA0158 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 6 H 13 N 3 O 6 P 1 MassAvg: 254.16 MassMono: 254.054197 Origin: N Source: natural TermSpec: C-term GPIAsn LIPID GPI-anchor amidated asparagine N-asparaginyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-aspartic acid residue to N-(aspart-1-yl)-glycosylphosphatidylinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0138 GPIAsp LIPID GPI-anchor amidated aspartate N-aspartyl-glycosylphosphatidylinositolethanolamine PSI-MOD MOD:00168 N-aspartyl-glycosylphosphatidylinositolethanolamine MOD:00168 A protein modification that effectively converts an L-aspartic acid residue to N-(aspart-1-yl)-glycosylphosphatidylinositolethanolamine. PubMed:7120400 RESID:AA0159 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 6 H 12 N 2 O 7 P 1 MassAvg: 255.14 MassMono: 255.038212 Origin: D Source: natural TermSpec: C-term GPIAsp LIPID GPI-anchor amidated aspartate N-aspartyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-cysteine residue to N-cysteinyl-glycosylphosphatidylinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0140 GPICys LIPID GPI-anchor amidated cysteine N-cysteinyl-glycosylphosphatidylinositolethanolamine PSI-MOD MOD:00169 N-cysteinyl-glycosylphosphatidylinositolethanolamine MOD:00169 A protein modification that effectively converts an L-cysteine residue to N-cysteinyl-glycosylphosphatidylinositolethanolamine. PubMed:2897081 RESID:AA0160 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 S 0 DiffMono: 123.008530 Formula: C 5 H 12 N 2 O 5 P 1 S 1 MassAvg: 243.19 MassMono: 243.020454 Origin: C Source: natural TermSpec: C-term GPICys LIPID GPI-anchor amidated cysteine N-cysteinyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts a glycine residue to N-glycyl-glycosylphosphatidylinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0141 GPIGly LIPID GPI-anchor amidated glycine N-glycyl-glycosylphosphatidylinositolethanolamine PSI-MOD MOD:00170 N-glycyl-glycosylphosphatidylinositolethanolamine MOD:00170 A protein modification that effectively converts a glycine residue to N-glycyl-glycosylphosphatidylinositolethanolamine. PubMed:2341397 RESID:AA0161 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 4 H 10 N 2 O 5 P 1 MassAvg: 197.11 MassMono: 197.032733 Origin: G Source: natural TermSpec: C-term GPIGly LIPID GPI-anchor amidated glycine N-glycyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-serine residue to N-seryl-glycosylphosphatidylinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0142 GPISer LIPID GPI-anchor amidated serine N-seryl-glycosylphosphatidylinositolethanolamine PSI-MOD MOD:00171 N-seryl-glycosylphosphatidylinositolethanolamine MOD:00171 A protein modification that effectively converts an L-serine residue to N-seryl-glycosylphosphatidylinositolethanolamine. PubMed:2111324 PubMed:8448158 RESID:AA0162 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 5 H 12 N 2 O 6 P 1 MassAvg: 227.13 MassMono: 227.043298 Origin: S Source: natural TermSpec: C-term GPISer LIPID GPI-anchor amidated serine N-seryl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylphosphatidylinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0136 GPIAla LIPID GPI-anchor amidated alanine N-alanyl-glycosylphosphatidylinositolethanolamine PSI-MOD MOD:00172 N-alanyl-glycosylphosphatidylinositolethanolamine MOD:00172 A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylphosphatidylinositolethanolamine. PubMed:7682556 PubMed:7744038 RESID:AA0163 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 5 H 12 N 2 O 5 P 1 MassAvg: 211.13 MassMono: 211.048383 Origin: A Source: natural TermSpec: C-term GPIAla LIPID GPI-anchor amidated alanine N-alanyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts an L-threonine residue to N-threonyl-glycosylphosphatidylinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0143 GPIThr LIPID GPI-anchor amidated threonine N-threonyl-glycosylphosphatidylinositolethanolamine PSI-MOD MOD:00173 N-threonyl-glycosylphosphatidylinositolethanolamine MOD:00173 A protein modification that effectively converts an L-threonine residue to N-threonyl-glycosylphosphatidylinositolethanolamine. RESID:AA0164 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 6 H 14 N 2 O 6 P 1 MassAvg: 241.16 MassMono: 241.058948 Origin: T Source: hypothetical TermSpec: C-term GPIThr LIPID GPI-anchor amidated threonine N-threonyl-glycosylphosphatidylinositolethanolamine A protein modification that effectively converts a glycine residue to N-glycyl-glycosylsphingolipidinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0146 GSIGly LIPID GPI-like-anchor amidated glycine N-glycyl-glycosylsphingolipidinositolethanolamine PSI-MOD MOD:00174 N-glycyl-glycosylsphingolipidinositolethanolamine MOD:00174 A protein modification that effectively converts a glycine residue to N-glycyl-glycosylsphingolipidinositolethanolamine. PubMed:12626404 PubMed:8404891 RESID:AA0165 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 4 H 10 N 2 O 5 P 1 MassAvg: 197.11 MassMono: 197.032733 Origin: G Source: hypothetical TermSpec: C-term GSIGly LIPID GPI-like-anchor amidated glycine N-glycyl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts an L-serine residue to N-seryl-glycosylsphingolipidinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0147 GSISer LIPID GPI-like-anchor amidated serine N-seryl-glycosylsphingolipidinositolethanolamine PSI-MOD MOD:00175 N-seryl-glycosylsphingolipidinositolethanolamine MOD:00175 A protein modification that effectively converts an L-serine residue to N-seryl-glycosylsphingolipidinositolethanolamine. PubMed:12626404 PubMed:2721485 PubMed:8269952 RESID:AA0166 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 5 H 12 N 2 O 6 P 1 MassAvg: 227.13 MassMono: 227.043298 Origin: S Source: natural TermSpec: C-term GSISer LIPID GPI-like-anchor amidated serine N-seryl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts an L-serine residue to O-(phosphoribosyl dephospho-coenzyme A)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0389 MOD_RES O-(phosphoribosyl dephospho-coenzyme A)serine O-(phosphoribosyl dephospho-coenzyme A)-L-serine O3-(phosphate-5-ribosyl-alpha-2-adenosine-5-diphosphate pantetheine)-L-serine O3-(phosphoribosyl dephospho-coenzyme A)-L-serine O3-2'-(5''-phosphoribosyl-3'-dephosphocoenzyme A)-L-serine OPRibdPCoASer PSI-MOD PhosphoribosyldephosphoCoA phosphoribosyl dephospho-coenzyme A MOD:00176 pRibodePcoA O-(phosphoribosyl dephospho-coenzyme A)-L-serine MOD:00176 A protein modification that effectively converts an L-serine residue to O-(phosphoribosyl dephospho-coenzyme A)-L-serine. PubMed:10924139 PubMed:11052675 PubMed:179809 PubMed:180526 PubMed:368065 RESID:AA0167 Unimod:395#S DiffAvg: 881.63 DiffFormula: C 26 H 42 N 7 O 19 P 3 S 1 DiffMono: 881.146903 Formula: C 29 H 47 N 8 O 21 P 3 S 1 MassAvg: 968.71 MassMono: 968.178931 Origin: S Source: natural TermSpec: none Unimod: Unimod:395 MOD_RES O-(phosphoribosyl dephospho-coenzyme A)serine O-(phosphoribosyl dephospho-coenzyme A)-L-serine O3-(phosphate-5-ribosyl-alpha-2-adenosine-5-diphosphate pantetheine)-L-serine O3-(phosphoribosyl dephospho-coenzyme A)-L-serine O3-2'-(5''-phosphoribosyl-3'-dephosphocoenzyme A)-L-serine OPRibdPCoASer PhosphoribosyldephosphoCoA phosphoribosyl dephospho-coenzyme A A protein modification that effectively converts an L-argininine residue to omega-N-(ADP-ribosyl)-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0053 (S)-2-amino-5-([imino([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)methyl]amino)pentanoic acid ADPRibArg MOD_RES ADP-ribosylarginine N(omega)-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-arginine N(omega)-alpha-D-ribofuranosyl-L-arginine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) N-(ADP-ribosyl)- (on Arginine) omega-N-(ADP-ribosyl)-L-arginine PSI-MOD ADP Ribose addition ADP-Ribosyl MOD:00177 From DeltaMass: Average Mass: 541. omega-N-(ADP-ribosyl)-L-arginine MOD:00177 A protein modification that effectively converts an L-argininine residue to omega-N-(ADP-ribosyl)-L-arginine. DeltaMass:0 PubMed:15842200 PubMed:209022 PubMed:3090031 PubMed:3923473 PubMed:6582062 RESID:AA0168 Unimod:213#R DiffAvg: 541.30 DiffFormula: C 15 H 21 N 5 O 13 P 2 DiffMono: 541.061109 Formula: C 21 H 33 N 9 O 14 P 2 MassAvg: 697.49 MassMono: 697.162220 Origin: R Source: natural TermSpec: none Unimod: Unimod:213 (S)-2-amino-5-([imino([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)methyl]amino)pentanoic acid ADPRibArg MOD_RES ADP-ribosylarginine N(omega)-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-arginine N(omega)-alpha-D-ribofuranosyl-L-arginine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) N-(ADP-ribosyl)- (on Arginine) omega-N-(ADP-ribosyl)-L-arginine ADP Ribose addition ADP-Ribosyl A protein modification that effectively converts an L-cysteine residue to S-(ADP-ribosyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0055 (R)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]sulfanyl)propanoic acid ADPRibCys MOD_RES ADP-ribosylcysteine S-(ADP-ribosyl)- (on Cysteine) S-(ADP-ribosyl)-L-cysteine S-L-cysteine alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) S-alpha-D-ribofuranosyl-L-cysteine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) PSI-MOD ADP Ribose addition ADP-Ribosyl MOD:00178 From DeltaMass: Average Mass: 541. S-(ADP-ribosyl)-L-cysteine MOD:00178 A protein modification that effectively converts an L-cysteine residue to S-(ADP-ribosyl)-L-cysteine. DeltaMass:0 PubMed:15842200 PubMed:3863818 RESID:AA0169 Unimod:213#C DiffAvg: 541.30 DiffFormula: C 15 H 21 N 5 O 13 P 2 S 0 DiffMono: 541.061109 Formula: C 18 H 26 N 6 O 14 P 2 S 1 MassAvg: 644.44 MassMono: 644.070294 Origin: C Source: natural TermSpec: none Unimod: Unimod:213 (R)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]sulfanyl)propanoic acid ADPRibCys MOD_RES ADP-ribosylcysteine S-(ADP-ribosyl)- (on Cysteine) S-(ADP-ribosyl)-L-cysteine S-L-cysteine alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) S-alpha-D-ribofuranosyl-L-cysteine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) ADP Ribose addition ADP-Ribosyl A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-glycerylphosphorylethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0403 (S)-2-amino-5-[2-([([2,3-dihydroxypropyl]oxy)(hydroxy)phosphoryl]oxy)ethyl]amino-5-oxopentanoic acid 5-L-glutamyl glycerylphosphorylethanolamine 5GlyceroPEtAGlu L-glutamyl 5-glycerophosphoethanolamine L-glutamyl 5-glycerophosphorylethanolamine L-glutamyl 5-glycerylphosphorylethanolamine MOD_RES 5-glutamyl glycerylphosphorylethanolamine PSI-MOD GlycerylPE glycerylphosphorylethanolamine MOD:00179 glycerylPE L-glutamyl 5-glycerylphosphorylethanolamine MOD:00179 A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-glycerylphosphorylethanolamine. PubMed:2511205 PubMed:2569467 PubMed:9662537 RESID:AA0170 Unimod:396#E DiffAvg: 197.13 DiffFormula: C 5 H 12 N 1 O 5 P 1 DiffMono: 197.045309 Formula: C 10 H 19 N 2 O 8 P 1 MassAvg: 326.24 MassMono: 326.087902 Origin: E Source: natural TermSpec: none Unimod: Unimod:396 (S)-2-amino-5-[2-([([2,3-dihydroxypropyl]oxy)(hydroxy)phosphoryl]oxy)ethyl]amino-5-oxopentanoic acid 5-L-glutamyl glycerylphosphorylethanolamine 5GlyceroPEtAGlu L-glutamyl 5-glycerophosphoethanolamine L-glutamyl 5-glycerophosphorylethanolamine L-glutamyl 5-glycerylphosphorylethanolamine MOD_RES 5-glutamyl glycerylphosphorylethanolamine GlycerylPE glycerylphosphorylethanolamine A protein modification that effectively converts an L-cysteine residue to S-sulfo-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2R)-2-amino-3-(sulfosulfanyl)propanoic acid 2-amino-3-(sulfothio)propanoic acid 3-(sulfosulfanyl)-L-alanine S-sulfo-L-cysteine S-sulfocysteine SSulfCys cysteine sulfate thioester cysteine-S-sulfonic acid PSI-MOD O-Sulfonation Sulfo MOD:00180 S-sulfo-L-cysteine MOD:00180 A protein modification that effectively converts an L-cysteine residue to S-sulfo-L-cysteine. PubMed:12876326 PubMed:14752058 PubMed:643076 RESID:AA0171 Unimod:40#C DiffAvg: 80.06 DiffFormula: C 0 H 0 N 0 O 3 S 1 DiffMono: 79.956815 Formula: C 3 H 5 N 1 O 4 S 2 MassAvg: 183.20 MassMono: 182.966000 Origin: C Source: natural TermSpec: none Unimod: Unimod:40 (2R)-2-amino-3-(sulfosulfanyl)propanoic acid 2-amino-3-(sulfothio)propanoic acid 3-(sulfosulfanyl)-L-alanine S-sulfo-L-cysteine S-sulfocysteine S-sulfocysteine SSulfCys cysteine sulfate thioester cysteine-S-sulfonic acid O-Sulfonation Sulfo A protein modification that effectively converts an L-tyrosine residue to O4'-sulfo-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0286 (S)-2-amino-3-(4-sulfooxyphenyl)propanoic acid 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-sulfate MOD_RES Sulfotyrosine O4'-sulfo-L-tyrosine O4-sulfotyrosine OSulfTyr Sulphation (of O of Tyrosine) Tyrosinyl Sulphate sulfationy tyrosine sulfate tyrosine-O-sulfonic acid tyrosine-O-sulphonic acid PSI-MOD O-Sulfonation Sulfo MOD:00181 From DeltaMass: Average Mass: 80 Average Mass Change:80 PubMed:9624161. O4'-sulfo-L-tyrosine MOD:00181 A protein modification that effectively converts an L-tyrosine residue to O4'-sulfo-L-tyrosine. DeltaMass:88 OMSSA:114 PubMed:10226369 PubMed:14752058 PubMed:2303439 PubMed:3778455 PubMed:3801003 RESID:AA0172 Unimod:40#Y DiffAvg: 80.06 DiffFormula: C 0 H 0 N 0 O 3 S 1 DiffMono: 79.956815 Formula: C 9 H 9 N 1 O 5 S 1 MassAvg: 243.23 MassMono: 243.020143 Origin: Y Source: natural TermSpec: none Unimod: Unimod:40 (S)-2-amino-3-(4-sulfooxyphenyl)propanoic acid 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-sulfate MOD_RES Sulfotyrosine O4'-sulfo-L-tyrosine O4-sulfotyrosine OSulfTyr Sulphation (of O of Tyrosine) Tyrosinyl Sulphate sulfationy tyrosine sulfate tyrosine-O-sulfonic acid tyrosine-O-sulphonic acid O-Sulfonation Sulfo A protein modification that effectively converts an L-histidine residue to L-bromohistidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0089 Br1His L-bromohistidine MOD_RES Bromohistidine PSI-MOD Bromo bromination MOD:00182 L-bromohistidine MOD:00182 A protein modification that effectively converts an L-histidine residue to L-bromohistidine. PubMed:2076468 PubMed:9033387 RESID:AA0173 Unimod:340#H DiffAvg: 78.90 DiffFormula: Br 1 C 0 H -1 N 0 O 0 DiffMono: 77.910512 Formula: Br 1 C 6 H 6 N 3 O 1 MassAvg: 216.04 MassMono: 214.969424 Origin: H Source: natural TermSpec: none Unimod: Unimod:340 Br1His L-bromohistidine MOD_RES Bromohistidine Bromo bromination A protein modification that effectively converts an L-phenylalanine residue to L-2'-bromophenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-3-(2-bromophenyl)propanoic acid 2'BrPhe L-2'-bromophenylalanine L-o-bromination of Phe with 79Br o-bromophenylalanine ortho-bromophenylalanine PSI-MOD Bromo bromination MOD:00183 From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa. L-2'-bromophenylalanine MOD:00183 A protein modification that effectively converts an L-phenylalanine residue to L-2'-bromophenylalanine. DeltaMass:83 PubMed:2059627 PubMed:2076468 PubMed:9033387 RESID:AA0174 DiffAvg: 78.90 DiffFormula: Br 1 C 0 H -1 N 0 O 0 DiffMono: 77.910512 Formula: Br 1 C 9 H 8 N 1 O 1 MassAvg: 226.07 MassMono: 224.978926 Origin: F Source: natural TermSpec: none (S)-2-amino-3-(2-bromophenyl)propanoic acid 2'BrPhe L-2'-bromophenylalanine L-o-bromination of Phe with 79Br o-bromophenylalanine ortho-bromophenylalanine Bromo bromination A protein modification that effectively converts an L-phenylalanine residue to L-3'-bromophenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-3-(3-bromophenyl)propanoic acid 3'BrPhe L-3'-bromophenylalanine m-bromophenylalanine meta-bromophenylalanine PSI-MOD Bromo bromination MOD:00184 L-3'-bromophenylalanine MOD:00184 A protein modification that effectively converts an L-phenylalanine residue to L-3'-bromophenylalanine. PubMed:2076468 PubMed:9033387 RESID:AA0175 DiffAvg: 78.90 DiffFormula: Br 1 C 0 H -1 N 0 O 0 DiffMono: 77.910512 Formula: Br 1 C 9 H 8 N 1 O 1 MassAvg: 226.07 MassMono: 224.978926 Origin: F Source: natural TermSpec: none (S)-2-amino-3-(3-bromophenyl)propanoic acid 3'BrPhe L-3'-bromophenylalanine m-bromophenylalanine meta-bromophenylalanine Bromo bromination A protein modification that effectively converts an L-phenylalanine residue to L-4'-bromophenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-(4-bromophenyl)propanoic acid 4'BrPhe L-4'-bromophenylalanine p-bromophenylalanine para-bromophenylalanine PSI-MOD Bromo bromination MOD:00185 L-4'-bromophenylalanine MOD:00185 A protein modification that effectively converts an L-phenylalanine residue to L-4'-bromophenylalanine. PubMed:2076468 PubMed:9033387 RESID:AA0176 DiffAvg: 78.90 DiffFormula: Br 1 C 0 H -1 N 0 O 0 DiffMono: 77.910512 Formula: Br 1 C 9 H 8 N 1 O 1 MassAvg: 226.07 MassMono: 224.978926 Origin: F Source: natural TermSpec: none (2S)-2-amino-3-(4-bromophenyl)propanoic acid 4'BrPhe L-4'-bromophenylalanine p-bromophenylalanine para-bromophenylalanine Bromo bromination A protein modification that effectively substitutes an L-tyrosine residue with 3,3',5-triiodo-L-thyronine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0295 (S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid 3',3'',5'-triiodo-L-thyronine 3,3',5-triiodo-L-thyronine 3,5,3'-Triiodothyronine (from Tyrosine) 3,5,3'-triiodo-L-thyronine 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine I3Thy MOD_RES Triiodothyronine O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine T3 liothyronine PSI-MOD Triiodothyronine triiodo MOD:00186 From DeltaMass: Average Mass: 470. 3,3',5-triiodo-L-thyronine MOD:00186 A protein modification that effectively substitutes an L-tyrosine residue with 3,3',5-triiodo-L-thyronine. ChEBI:18258 DeltaMass:0 RESID:AA0177 Unimod:397 DiffAvg: 469.79 DiffFormula: C 6 H 1 I 3 N 0 O 1 DiffMono: 469.716158 Formula: C 15 H 10 I 3 N 1 O 3 MassAvg: 632.96 MassMono: 632.779486 Origin: Y Source: natural TermSpec: none Unimod: Unimod:397 (S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid 3',3'',5'-triiodo-L-thyronine 3,3',5-triiodo-L-thyronine 3,5,3'-Triiodothyronine (from Tyrosine) 3,5,3'-triiodo-L-thyronine 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine I3Thy MOD_RES Triiodothyronine O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine T3 liothyronine Triiodothyronine triiodo A protein modification that effectively substitutes an L-tyrosine residue with L-thyroxine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0294 (S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid 3',3'',5',5''-tetraiodo-L-thyronine 3,3',5,5'-tetraiodo-L-thyronine 3,5,3',5'-tetraiodo-L-thyronine 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine I4Thy L-thyroxine MOD_RES Thyroxine O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine T4 PSI-MOD Thyroxine tetraiodo MOD:00187 L-thyroxine MOD:00187 A protein modification that effectively substitutes an L-tyrosine residue with L-thyroxine. ChEBI:18332 PubMed:6704086 RESID:AA0178 Unimod:398 DiffAvg: 595.68 DiffFormula: C 6 H 0 I 4 N 0 O 1 DiffMono: 595.612805 Formula: C 15 H 9 I 4 N 1 O 3 MassAvg: 758.86 MassMono: 758.676134 Origin: Y Source: natural TermSpec: none Unimod: Unimod:398 (S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid 3',3'',5',5''-tetraiodo-L-thyronine 3,3',5,5'-tetraiodo-L-thyronine 3,5,3',5'-tetraiodo-L-thyronine 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine I4Thy L-thyroxine MOD_RES Thyroxine O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine T4 Thyroxine tetraiodo A protein modification that effectively converts an L-tryptophan residue to 6'-bromo-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0051 (2S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid 6'-BrTrp 6'-bromo-L-tryptophan MOD_RES 6'-bromotryptophan PSI-MOD Bromo bromination MOD:00188 6'-bromo-L-tryptophan MOD:00188 A protein modification that effectively converts an L-tryptophan residue to 6'-bromo-L-tryptophan. PubMed:12118011 PubMed:9030520 PubMed:9033387 PubMed:9434739 RESID:AA0179 Unimod:340#W DiffAvg: 78.90 DiffFormula: Br 1 C 0 H -1 N 0 O 0 DiffMono: 77.910512 Formula: Br 1 C 11 H 9 N 2 O 1 MassAvg: 265.11 MassMono: 263.989825 Origin: W Source: natural TermSpec: none Unimod: Unimod:398 (2S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid 6'-BrTrp 6'-bromo-L-tryptophan MOD_RES 6'-bromotryptophan Bromo bromination A protein modification that effectively converts an L-serine residue to dehydroalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0006 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dha Dha(Ser) MOD_RES 2,3-didehydroalanine (Ser) anhydroserine beta-elim-s dehydro dehydroalanine phospholosss PSI-MOD Dehydrated MOD:00189 dehydroalanine (Ser) MOD:00189 A protein modification that effectively converts an L-serine residue to dehydroalanine. DeltaMass:0 OMSSA:140 OMSSA:164 OMSSA:96 PubMed:10220322 PubMed:1547888 PubMed:1815586 PubMed:2914619 PubMed:7947813 PubMed:8239649 RESID:AA0181#SER Unimod:23#S DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 3 H 3 N 1 O 1 MassAvg: 69.06 MassMono: 69.021464 Origin: S Source: natural TermSpec: none Unimod: Unimod:23 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dha Dha(Ser) MOD_RES 2,3-didehydroalanine (Ser) anhydroserine beta-elim-s dehydro dehydroalanine phospholosss Dehydrated A protein modification that effectively converts an L-threonine residue to dehydrobutyrine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0007 (2Z)-2-aminobut-2-enoic acid (Z)-2-amino-2-butenoic acid (Z)-2-aminobutenoic acid (Z)-dehydrobutyrine 2,3-didehydrobutyrine 3-methyldehydroalanine Dehydroamino butyric acid Dhb Dhb(Thr) MOD_RES 2,3-didehydrobutyrine alpha,beta-dehydroaminobutyric acid anhydrothreonine beta-elim-t dehydro methyl-dehydroalanine phospholosst PSI-MOD Dehydrated Dehydration MOD:00190 dehydrobutyrine (Thr) MOD:00190 A protein modification that effectively converts an L-threonine residue to dehydrobutyrine. DeltaMass:0 OMSSA:141 OMSSA:164 OMSSA:97 PubMed:1547888 PubMed:3769923 RESID:AA0182 Unimod:23#T DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 4 H 5 N 1 O 1 MassAvg: 83.09 MassMono: 83.037114 Origin: T Source: natural TermSpec: none Unimod: Unimod:23 (2Z)-2-aminobut-2-enoic acid (Z)-2-amino-2-butenoic acid (Z)-2-aminobutenoic acid (Z)-dehydrobutyrine 2,3-didehydrobutyrine 3-methyldehydroalanine Dehydroamino butyric acid Dhb Dhb(Thr) MOD_RES 2,3-didehydrobutyrine alpha,beta-dehydroaminobutyric acid anhydrothreonine beta-elim-t dehydro methyl-dehydroalanine phospholosst Dehydrated Dehydrated Dehydration A protein modification that effectively converts L-tyrosine to (Z)-2,3-didehydrotyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0002 (2Z)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid (Z)-2,3-didehydrogenated tyrosine (Z)-2,3-didehydrotyrosine MOD_RES (Z)-2,3-didehydrotyrosine Z-dHTyr amino-(para-hydroxybenzylidenyl)acetic acid cis-dehydrotyrosine green fluorescent protein chromophore para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein chromophore PSI-MOD 2-amino-3-oxo-butanoic_acid Didehydro MOD:00191 incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 (Z)-2,3-didehydrotyrosine MOD:00191 A protein modification that effectively converts L-tyrosine to (Z)-2,3-didehydrotyrosine. PubMed:1347277 PubMed:9631087 RESID:AA0183 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 9 H 7 N 1 O 2 MassAvg: 161.16 MassMono: 161.047678 Origin: Y Source: natural TermSpec: none (2Z)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid (Z)-2,3-didehydrogenated tyrosine (Z)-2,3-didehydrotyrosine MOD_RES (Z)-2,3-didehydrotyrosine Z-dHTyr amino-(para-hydroxybenzylidenyl)acetic acid cis-dehydrotyrosine green fluorescent protein chromophore para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein chromophore 2-amino-3-oxo-butanoic_acid Didehydro A protein modification that effectively crosslinks an L-serine residue and a glycine residue to form L-serine 5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0049 (2-[(1R)-1-amino-2-hydroxyethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[1-amino-2-hydroxyethyl]-1-carboxymethyl-1-imidazolin-5-one 4-methylidene-imidazole-5-one (MIO) active site CROSSLNK 5-imidazolinone (Ser-Gly) L-serine 5-imidazolinone glycine green fluorescent protein chromophore para-hydroxybenzylidene-imidazolidinone chromophore seryl-5-imidazolinone glycine PSI-MOD MOD:00192 Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. L-serine 5-imidazolinone glycine MOD:00192 A protein modification that effectively crosslinks an L-serine residue and a glycine residue to form L-serine 5-imidazolinone glycine. ChEBI:21393 PubMed:1347277 PubMed:9631087 RESID:AA0184 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 5 H 6 N 2 O 2 MassAvg: 126.11 MassMono: 126.042927 Origin: G, S Source: natural TermSpec: none (2-[(1R)-1-amino-2-hydroxyethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[1-amino-2-hydroxyethyl]-1-carboxymethyl-1-imidazolin-5-one 4-methylidene-imidazole-5-one (MIO) active site CROSSLNK 5-imidazolinone (Ser-Gly) L-serine 5-imidazolinone glycine green fluorescent protein chromophore para-hydroxybenzylidene-imidazolidinone chromophore seryl-5-imidazolinone glycine A protein modification that effectively converts an L-cysteine residue to L-oxoalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0034 (S)-2-amino-3-oxopropanoic acid 2-amino-3-oxopropionic acid L-3-oxoalanine L-amino-malonic acid semialdehyde L-aminomalonaldehydic acid MOD_RES 3-oxoalanine (Cys) Oxala(Cys) PSI-MOD C(alpha)-formylglycine L-serinesemialdehyde MOD:00193 L-3-oxoalanine (Cys) MOD:00193 A protein modification that effectively converts an L-cysteine residue to L-oxoalanine. DeltaMass:350 PubMed:14563551 PubMed:7628016 PubMed:8681943 PubMed:9478923 RESID:AA0185#CYS Unimod:402#C DiffAvg: -18.08 DiffFormula: C 0 H -2 N 0 O 1 S -1 DiffMono: -17.992806 Formula: C 3 H 3 N 1 O 2 MassAvg: 85.06 MassMono: 85.016378 Origin: C Source: natural TermSpec: none Unimod: Unimod:402 (S)-2-amino-3-oxopropanoic acid 2-amino-3-oxopropionic acid L-3-oxoalanine L-amino-malonic acid semialdehyde L-aminomalonaldehydic acid MOD_RES 3-oxoalanine (Cys) Oxala(Cys) C(alpha)-formylglycine L-serinesemialdehyde A protein modification that effectively converts an L-serine residue to an amino-terminal lactic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: uniprot.ptm:PTM-0163 (2R)-2-hydroxypropanoic acid 2-hydroxypropionic acid Lac(Ser) MOD_RES Lactic acid alpha-hydroxypropionic acid lactic acid PSI-MOD Ser->LacticAcid lactic acid from N-term Ser MOD:00194 lactic acid MOD:00194 A protein modification that effectively converts an L-serine residue to an amino-terminal lactic acid. PubMed:7607233 RESID:AA0186 Unimod:403#S DiffAvg: -15.02 DiffFormula: C 0 H -1 N -1 O 0 DiffMono: -15.010899 Formula: C 3 H 5 O 2 MassAvg: 73.07 MassMono: 73.028954 Origin: S TermSpec: N-term Unimod: Unimod:403 (2R)-2-hydroxypropanoic acid 2-hydroxypropionic acid Lac(Ser) MOD_RES Lactic acid alpha-hydroxypropionic acid lactic acid Ser->LacticAcid lactic acid from N-term Ser A protein modification that effectively crosslinks an L-alanine residue and a glycine residue to form L-alanine 5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0045 (2-[(1S)-1-aminoethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[1-aminoethyl]-1-carboxymethyl-1-imidazolin-5-one 4-methylidene-imidazole-5-one active site CROSSLNK 5-imidazolinone (Ala-Gly) L-alanine 5-imidazolinone glycine XLNK-1Ala-NGly(Imidazole) alanyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore PSI-MOD MOD:00195 Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. L-alanine 5-imidazolinone glycine MOD:00195 A protein modification that effectively crosslinks an L-alanine residue and a glycine residue to form L-alanine 5-imidazolinone glycine. PubMed:10220322 RESID:AA0187 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 5 H 6 N 2 O 1 MassAvg: 110.12 MassMono: 110.048013 Origin: A, G Source: natural TermSpec: none (2-[(1S)-1-aminoethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[1-aminoethyl]-1-carboxymethyl-1-imidazolin-5-one 4-methylidene-imidazole-5-one active site CROSSLNK 5-imidazolinone (Ala-Gly) L-alanine 5-imidazolinone glycine XLNK-1Ala-NGly(Imidazole) alanyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form L-cysteine 5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0047 (2-[(1R)-1-amino-2-sulfanylethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[1-amino-2-sulfanylethyl]-1-carboxymethyl-1-imidazolin-5-one 4-methylidene-imidazole-5-one (MIO) active site CROSSLNK 5-imidazolinone (Cys-Gly) L-cysteine 5-imidazolinone glycine XLNK-1Cys-NGly(Imidazole) cysteinyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore PSI-MOD MOD:00196 Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365. L-cysteine 5-imidazolinone glycine MOD:00196 A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form L-cysteine 5-imidazolinone glycine. PubMed:1537807 RESID:AA0188 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 5 H 6 N 2 O 1 S 1 MassAvg: 142.18 MassMono: 142.020084 Origin: C, G Source: natural TermSpec: none (2-[(1R)-1-amino-2-sulfanylethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[1-amino-2-sulfanylethyl]-1-carboxymethyl-1-imidazolin-5-one 4-methylidene-imidazole-5-one (MIO) active site CROSSLNK 5-imidazolinone (Cys-Gly) L-cysteine 5-imidazolinone glycine XLNK-1Cys-NGly(Imidazole) cysteinyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore A protein modification that effectively crosslinks an L-glutamine residue and a glycine residue to form 2-imino-glutamine 5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0013 2,N-didehydroglutaminyl-5-imidazolinone glycine 2-(3-carbamoyl-1-imino-propyl)-1-carboxymethyl-1-imidazolin-5-one 2-imino-glutamine 5-imidazolinone glycine CROSSLNK 2-iminomethyl-5-imidazolinone (Gln-Gly) [2-(3-carbamoyl-1-imino-propyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid [2-(4-amino-4-oxobutanimidoyl)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid fluorescent protein FP583 chromophore para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein chromophore PSI-MOD MOD:00197 Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. 2-imino-glutamine 5-imidazolinone glycine MOD:00197 A protein modification that effectively crosslinks an L-glutamine residue and a glycine residue to form 2-imino-glutamine 5-imidazolinone glycine. PubMed:11050230 PubMed:11209050 RESID:AA0189 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 DiffMono: -20.026215 Formula: C 7 H 7 N 3 O 2 MassAvg: 165.15 MassMono: 165.053826 Origin: G, Q Source: natural TermSpec: none 2,N-didehydroglutaminyl-5-imidazolinone glycine 2-(3-carbamoyl-1-imino-propyl)-1-carboxymethyl-1-imidazolin-5-one 2-imino-glutamine 5-imidazolinone glycine CROSSLNK 2-iminomethyl-5-imidazolinone (Gln-Gly) [2-(3-carbamoyl-1-imino-propyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid [2-(4-amino-4-oxobutanimidoyl)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid fluorescent protein FP583 chromophore para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein chromophore A protein modification that effectively converts an L-alanine residue to D-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0112 (R)-2-aminopropanoic acid D-Ala(Ala) D-alanine MOD_RES D-alanine (Ala) PSI-MOD MOD:00198 D-alanine (Ala) MOD:00198 A protein modification that effectively converts an L-alanine residue to D-alanine. PubMed:15023056 PubMed:7287302 PubMed:7961627 RESID:AA0191#ALA DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 3 H 5 N 1 O 1 MassAvg: 71.08 MassMono: 71.037114 Origin: A Source: natural TermSpec: none (R)-2-aminopropanoic acid D-Ala(Ala) D-alanine MOD_RES D-alanine (Ala) A protein modification that effectively converts an L-isoleucine residue to a D-allo-isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0114 (2R,3S)-2-amino-3-methylpentanoic acid 2-azanyl-3-methylpentanoic acid 3-methyl-norvaline D-Ile D-allo-isoleucine D-threo-isoleucine MOD_RES D-allo-isoleucine allo-D-isoleucine alpha-amino-beta-methylvaleric acid PSI-MOD MOD:00199 D-allo-isoleucine MOD:00199 A protein modification that effectively converts an L-isoleucine residue to a D-allo-isoleucine. ChEBI:30007 PubMed:8223491 RESID:AA0192 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 6 H 11 N 1 O 1 MassAvg: 113.16 MassMono: 113.084064 Origin: I Source: natural TermSpec: none (2R,3S)-2-amino-3-methylpentanoic acid 2-azanyl-3-methylpentanoic acid 3-methyl-norvaline D-Ile D-allo-isoleucine D-threo-isoleucine MOD_RES D-allo-isoleucine allo-D-isoleucine alpha-amino-beta-methylvaleric acid A protein modification that effectively converts an L-methionine residue to D-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0120 (2R)-2-amino-4-(methylsulfanyl)butanoic acid 2-amino-4-(methylthio)butanoic acid 2-amino-4-(methylthio)butyric acid D-Met D-methionine MOD_RES D-methionine PSI-MOD MOD:00200 D-methionine MOD:00200 A protein modification that effectively converts an L-methionine residue to D-methionine. ChEBI:29984 PubMed:16033333 PubMed:2542051 RESID:AA0193 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 S 0 DiffMono: 0.000000 Formula: C 5 H 9 N 1 O 1 S 1 MassAvg: 131.19 MassMono: 131.040485 Origin: M Source: natural TermSpec: none (2R)-2-amino-4-(methylsulfanyl)butanoic acid 2-amino-4-(methylthio)butanoic acid 2-amino-4-(methylthio)butyric acid D-Met D-methionine MOD_RES D-methionine A protein modification that effectively converts an L-phenylalanine residue to D-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0121 (R)-2-amino-3-phenylpropanoic acid D-Phe D-phenylalanine MOD_RES D-phenylalanine PSI-MOD MOD:00201 D-phenylalanine MOD:00201 A protein modification that effectively converts an L-phenylalanine residue to D-phenylalanine. ChEBI:29996 PubMed:1548227 PubMed:1644179 PubMed:2597281 RESID:AA0194 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 9 H 9 N 1 O 1 MassAvg: 147.18 MassMono: 147.068414 Origin: F Source: natural TermSpec: none (R)-2-amino-3-phenylpropanoic acid D-Phe D-phenylalanine MOD_RES D-phenylalanine A protein modification that effectively converts an L-serine residue to D-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0308 (R)-2-amino-3-hydroxypropanoic acid D-Ser(Ser) D-serine MOD_RES D-serine (Ser) PSI-MOD MOD:00202 D-serine (Ser) MOD:00202 A protein modification that effectively converts an L-serine residue to D-serine. PubMed:7973665 RESID:AA0195#SER DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 3 H 5 N 1 O 2 MassAvg: 87.08 MassMono: 87.032028 Origin: S Source: natural TermSpec: none (R)-2-amino-3-hydroxypropanoic acid D-Ser(Ser) D-serine MOD_RES D-serine (Ser) A protein modification that effectively converts an L-asparagine residue to D-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0115 (R)-2-amino-4-butanediamic acid D-Asn D-alpha-aminosuccinamic acid D-asparagine D-aspartic acid beta-amide MOD_RES D-asparagine PSI-MOD MOD:00203 D-asparagine MOD:00203 A protein modification that effectively converts an L-asparagine residue to D-asparagine. ChEBI:29957 PubMed:1859408 RESID:AA0196 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 4 H 6 N 2 O 2 MassAvg: 114.10 MassMono: 114.042927 Origin: N Source: natural TermSpec: none (R)-2-amino-4-butanediamic acid D-Asn D-alpha-aminosuccinamic acid D-asparagine D-aspartic acid beta-amide MOD_RES D-asparagine A protein modification that effectively converts an L-leucine residue to D-leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0119 (2R)-2-amino-4-methylpentanoic acid D-Leu D-leucine MOD_RES D-leucine alpha-aminoisocaproic acid PSI-MOD MOD:00204 D-leucine MOD:00204 A protein modification that effectively converts an L-leucine residue to D-leucine. ChEBI:30005 PubMed:10461743 PubMed:12135762 PubMed:1358533 PubMed:1548227 RESID:AA0197 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 6 H 11 N 1 O 1 MassAvg: 113.16 MassMono: 113.084064 Origin: L Source: natural TermSpec: none (2R)-2-amino-4-methylpentanoic acid D-Leu D-leucine MOD_RES D-leucine alpha-aminoisocaproic acid A protein modification that effectively converts an L-tryptophan residue to D-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0123 (R)-2-amino-3-(1H-indol-3-yl)propanoic acid D-Trp D-tryptophan MOD_RES D-tryptophan alpha-amino-beta-(3-indolyl)propionoic acid PSI-MOD MOD:00205 D-tryptophan MOD:00205 A protein modification that effectively converts an L-tryptophan residue to D-tryptophan. ChEBI:29955 PubMed:8910408 RESID:AA0198 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 11 H 10 N 2 O 1 MassAvg: 186.21 MassMono: 186.079313 Origin: W Source: natural TermSpec: none (R)-2-amino-3-(1H-indol-3-yl)propanoic acid D-Trp D-tryptophan MOD_RES D-tryptophan alpha-amino-beta-(3-indolyl)propionoic acid A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine. Origin: Source: TermSpec: uniprot.ptm:PTM-0394 L-isoglutamyl-polyglycine MOD_RES 5-glutamyl polyglycine gamma-glutamylpolyglycine PSI-MOD MOD:00206 L-isoglutamyl-polyglycine MOD:00206 A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine. ChEBI:21343 PubMed:10074368 PubMed:16368691 PubMed:7992051 RESID:AA0201 Origin: E Source: natural TermSpec: none L-isoglutamyl-polyglycine MOD_RES 5-glutamyl polyglycine gamma-glutamylpolyglycine A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid. Origin: Source: TermSpec: uniprot.ptm:PTM-0395 L-isoglutamyl-polyglutamic acid gamma-glutamylpolyglutamic acid PSI-MOD MOD:00207 L-isoglutamyl-polyglutamic acid MOD:00207 A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid. PubMed:10747868 PubMed:1680872 RESID:AA0202 Origin: E Source: natural TermSpec: none L-isoglutamyl-polyglutamic acid gamma-glutamylpolyglutamic acid A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphoadenosine through a phosphodiester bond to form O4'-(phospho-5'-adenosine)-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0332 (2S)-2-amino-3-[4-(5'-adenosine phosphonoxy)phenyl]propanoic acid 5'-adenylic-O-tyrosine MOD_RES O-AMP-tyrosine O-5'-Adenosylation ( of Tyrosine) O4'-(phospho-5'-adenosine)-L-tyrosine O4'-L-tyrosine 5'-adenosine phosphodiester OAMPTyr hydrogen 5'-adenylate tyrosine ester PSI-MOD AMP binding site Phosphoadenosine MOD:00208 From DeltaMass: Average Mass: 329. O4'-(phospho-5'-adenosine)-L-tyrosine MOD:00208 A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphoadenosine through a phosphodiester bond to form O4'-(phospho-5'-adenosine)-L-tyrosine. DeltaMass:0 PubMed:5543675 RESID:AA0203 Unimod:405#Y DiffAvg: 329.21 DiffFormula: C 10 H 12 N 5 O 6 P 1 DiffMono: 329.052520 Formula: C 19 H 21 N 6 O 8 P 1 MassAvg: 492.38 MassMono: 492.115848 Origin: Y Source: natural TermSpec: none Unimod: Unimod:405 (2S)-2-amino-3-[4-(5'-adenosine phosphonoxy)phenyl]propanoic acid 5'-adenylic-O-tyrosine MOD_RES O-AMP-tyrosine O-5'-Adenosylation ( of Tyrosine) O4'-(phospho-5'-adenosine)-L-tyrosine O4'-L-tyrosine 5'-adenosine phosphodiester OAMPTyr hydrogen 5'-adenylate tyrosine ester AMP binding site Phosphoadenosine A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: uniprot.ptm:PTM-0268 (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid (S,Z)-S-(2-aminovinyl)cysteine CROSSLNK S-(2-aminovinyl)-D-cysteine (Ser-Cys) S-(2-aminovinyl)-D-cysteine XLNK-(D)SCys-VinAm PSI-MOD MOD:00209 Cross-link 2. S-(2-aminovinyl)-D-cysteine (Cys-Ser) MOD:00209 A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine. PubMed:3181159 PubMed:3769923 RESID:AA0204#SER DiffAvg: -64.04 DiffFormula: C -1 H -4 N 0 O -3 S 0 DiffMono: -64.016044 Formula: C 5 H 7 N 2 O 1 S 1 MassAvg: 143.18 MassMono: 143.027909 Origin: C, S TermSpec: C-term (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid (S,Z)-S-(2-aminovinyl)cysteine CROSSLNK S-(2-aminovinyl)-D-cysteine (Ser-Cys) S-(2-aminovinyl)-D-cysteine XLNK-(D)SCys-VinAm A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0107 (2R)-2-amino-3-(hydroxysulfanyl)propanoic acid (2R)-2-amino-3-(oxido-lambda(4)-sulfanyl)propanoic acid [tautomer] 2-amino-2-carboxyethanesulfenic acid 2-amino-3-sulfinylpropanoic acid [tautomer] 3-sulfenoalanine ACT_SITE Cysteine sulfenic acid (-SOH) intermediate CysOH L-cysteine sulfenic acid MOD_RES Cysteine sulfenic acid (-SOH) S-hydroxycysteine S-oxocysteine [tautomer] S-oxycysteine [tautomer] Sulfenic Acid (from Cysteine) cysteine S-oxide [tautomer] cysteine sulfoxide [tautomer] cysteine sulphenic acid mod193 PSI-MOD Oxidation MOD:00210 From DeltaMass: Average Mass: 16 Average Mass Change:16 Notes:Green et al. in J. B. C. 270, 18209-18211 (1995) quote Kim and Raines in Eur. J. Biochem. 224, 109-114 (1994). Kim and Raines using ESI-MS and sulfhydryl group titration found that bovine seminal ribonuclease contains a single oxidized sulfhydryl group, which cannot participate in a disulfide bond. This form of cysteine is called sulfenic acid (-SOH). L-cysteine sulfenic acid MOD:00210 A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid. DeltaMass:41 OMSSA:193 PubMed:10964927 PubMed:2501303 PubMed:8756456 PubMed:9214307 PubMed:9586994 PubMed:9587003 RESID:AA0205 Unimod:35#C DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 S 0 DiffMono: 15.994915 Formula: C 3 H 5 N 1 O 2 S 1 MassAvg: 119.14 MassMono: 119.004099 Origin: C Source: natural TermSpec: none Unimod: Unimod:35 (2R)-2-amino-3-(hydroxysulfanyl)propanoic acid (2R)-2-amino-3-(oxido-lambda(4)-sulfanyl)propanoic acid [tautomer] 2-amino-2-carboxyethanesulfenic acid 2-amino-3-sulfinylpropanoic acid [tautomer] 3-sulfenoalanine ACT_SITE Cysteine sulfenic acid (-SOH) intermediate CysOH L-cysteine sulfenic acid MOD_RES Cysteine sulfenic acid (-SOH) S-hydroxycysteine S-oxocysteine [tautomer] S-oxycysteine [tautomer] Sulfenic Acid (from Cysteine) cysteine S-oxide [tautomer] cysteine sulfoxide [tautomer] cysteine sulphenic acid mod193 Oxidation A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: uniprot.ptm:PTM-0429 (2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid 1-(cystein-S-yl)-glycinate ACT_SITE Glycyl thioester intermediate S-(2-amino-1-oxoethyl)cysteine S-(glycyl)-L-cysteine XLNK-SCys-1Gly glycine cysteine thioester PSI-MOD MOD:00211 Cross-link 2. For the modification of a C-terminal glycine by formation of a thioester bond with free L-cysteine see MOD:01777 [JSG]. S-(glycyl)-L-cysteine (Cys-Gly) MOD:00211 A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine. ChEBI:22050 PubMed:3306404 RESID:AA0206 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 5 H 7 N 2 O 2 S 1 MassAvg: 159.18 MassMono: 159.022823 Origin: C, G TermSpec: C-term (2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid 1-(cystein-S-yl)-glycinate ACT_SITE Glycyl thioester intermediate S-(2-amino-1-oxoethyl)cysteine S-(glycyl)-L-cysteine XLNK-SCys-1Gly glycine cysteine thioester A protein modification that effectively converts an L-cysteine residue to S-4-hydroxycinnamyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0414 (2R)-2-amino-3-([(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]sulfanyl)propanoic acid MOD_RES S-(4-hydroxycinnamyl)cysteine S-4-hydroxycinnamyl-L-cysteine S-para-coumaryl-L-cysteine cinnamate cysteine thioester PSI-MOD Hydroxycinnamyl hydroxycinnamyl MOD:00212 S-4-hydroxycinnamyl-L-cysteine MOD:00212 A protein modification that effectively converts an L-cysteine residue to S-4-hydroxycinnamyl-L-cysteine. PubMed:7947803 PubMed:7981196 RESID:AA0207 Unimod:407 DiffAvg: 146.14 DiffFormula: C 9 H 6 N 0 O 2 S 0 DiffMono: 146.036779 Formula: C 12 H 11 N 1 O 3 S 1 MassAvg: 249.28 MassMono: 249.045964 Origin: C Source: natural TermSpec: none Unimod: Unimod:407 (2R)-2-amino-3-([(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]sulfanyl)propanoic acid MOD_RES S-(4-hydroxycinnamyl)cysteine S-4-hydroxycinnamyl-L-cysteine S-para-coumaryl-L-cysteine cinnamate cysteine thioester Hydroxycinnamyl hydroxycinnamyl A protein modification that effectively cross-links an L-serine residue to the polymer chondroitin sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. Origin: Source: TermSpec: chondroitin 4-sulfate (chondroitin sulfate A) chondroitin 6-sulfate (chondroitin sulfate C) chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine; poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-6-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine PSI-MOD MOD:00213 chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine MOD:00213 A protein modification that effectively cross-links an L-serine residue to the polymer chondroitin sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. PubMed:1794445 PubMed:1898736 PubMed:3472204 RESID:AA0208 Origin: S Source: natural TermSpec: none chondroitin 4-sulfate (chondroitin sulfate A) chondroitin 6-sulfate (chondroitin sulfate C) chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine; poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-6-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine A protein modification that effectively cross-links an L-serine residue to the polymer dermatan 4-sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. Origin: Source: TermSpec: beta-heparin chondroitin sulfate B dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine poly[beta-1,4-L-idopyranuronosyl-alpha-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine PSI-MOD MOD:00214 dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine MOD:00214 A protein modification that effectively cross-links an L-serine residue to the polymer dermatan 4-sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. PubMed:2914936 PubMed:3472204 RESID:AA0209 Origin: S Source: natural TermSpec: none beta-heparin chondroitin sulfate B dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine poly[beta-1,4-L-idopyranuronosyl-alpha-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine A protein modification that effectively cross-links an L-serine residue to the polymer heparan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. Origin: Source: TermSpec: heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine heparin heparitin sulfate poly[alpha-1,4-(2-sulfate D-glucopyranuronosyl)-beta-1,4-(2-sulfamino-2-deoxy-6-sulfate D-glucosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine PSI-MOD MOD:00215 heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine MOD:00215 A protein modification that effectively cross-links an L-serine residue to the polymer heparan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. PubMed:3472204 RESID:AA0210 Origin: S Source: natural TermSpec: none heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine heparin heparitin sulfate poly[alpha-1,4-(2-sulfate D-glucopyranuronosyl)-beta-1,4-(2-sulfamino-2-deoxy-6-sulfate D-glucosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine A protein modification that effectively converts an L-lysine residue to N6-formyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0192 (2S)-2-amino-6-(formylamino)hexanoic acid MOD_RES N6-formyllysine N(zeta)-formyllysine N6-formyl-L-lysine N6-formylated L-lysine N6FoLys epsilon-formyllysine formylk PSI-MOD Formyl Formylation MOD:00216 N6-formyl-L-lysine MOD:00216 A protein modification that effectively converts an L-lysine residue to N6-formyl-L-lysine. OMSSA:43 PubMed:15799070 RESID:AA0211 Unimod:122#K DiffAvg: 28.01 DiffFormula: C 1 H 0 N 0 O 1 DiffMono: 27.994915 Formula: C 7 H 12 N 2 O 2 MassAvg: 156.19 MassMono: 156.089878 Origin: K Source: natural TermSpec: none Unimod: Unimod:122 (2S)-2-amino-6-(formylamino)hexanoic acid MOD_RES N6-formyllysine N(zeta)-formyllysine N6-formyl-L-lysine N6-formylated L-lysine N6FoLys epsilon-formyllysine formylk Formyl Formylation A protein modification that effectively converts an L-proline residue to O4-arabinosyl-L-hydroxyproline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0545 (2S,4R)-4-(beta-L-arabinofuranosyloxy)pyrrolidine-2-carboxylic acid 4-(beta-L-arabinofuranosyloxy)proline 4-Glycosyloxy- (pentosyl,C5) (of Proline) O4-arabinosyl-L-hydroxyproline O4-glycosyl-hydroxyproline OAra4HyPro beta-arabinofuranosyl-4-hydroxyproline PSI-MOD Glycosyl glycosyl-L-hydroxyproline MOD:00217 secondary to RESID:AA0030; From DeltaMass: Average Mass: 147. O4-arabinosyl-L-hydroxyproline MOD:00217 A protein modification that effectively converts an L-proline residue to O4-arabinosyl-L-hydroxyproline. DeltaMass:0 PubMed:666730 PubMed:7852316 RESID:AA0212 Unimod:408 DiffAvg: 148.11 DiffFormula: C 5 H 8 N 0 O 5 DiffMono: 148.037173 Formula: C 10 H 15 N 1 O 6 MassAvg: 245.23 MassMono: 245.089937 Origin: P Source: natural TermSpec: none Unimod: Unimod:408 (2S,4R)-4-(beta-L-arabinofuranosyloxy)pyrrolidine-2-carboxylic acid 4-(beta-L-arabinofuranosyloxy)proline 4-Glycosyloxy- (pentosyl,C5) (of Proline) O4-arabinosyl-L-hydroxyproline O4-glycosyl-hydroxyproline OAra4HyPro beta-arabinofuranosyl-4-hydroxyproline Glycosyl glycosyl-L-hydroxyproline A protein modification that effectively crosslinks an L-serine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-serine. Origin: Source: TermSpec: uniprot.ptm:PTM-0227 (S)-2-amino-3-(5'-ribonucleic acid phosphonoxy)propanoic acid MOD_RES O-(5'-phospho-RNA)-serine O-(phospho-5'-RNA)-L-serine O3-(phospho-5'-RNA)-L-serine O3-L-serine 5'-RNA phosphodiester PSI-MOD MOD:00218 O-(phospho-5'-RNA)-L-serine MOD:00218 A protein modification that effectively crosslinks an L-serine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-serine. PubMed:1705009 RESID:AA0213 Origin: S Source: natural TermSpec: none (S)-2-amino-3-(5'-ribonucleic acid phosphonoxy)propanoic acid MOD_RES O-(5'-phospho-RNA)-serine O-(phospho-5'-RNA)-L-serine O3-(phospho-5'-RNA)-L-serine O3-L-serine 5'-RNA phosphodiester A protein modification that effectively converts an L-arginine residue to L-citrulline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0092 (S)-2-amino-5-(carbamoylamino)pentanoic acid 2-amino-5-(aminocarbonyl)aminopentanoic acid Cit Citrulline L-citrulline MOD_RES Citrulline N5-(aminocarbonyl)ornithine N5-carbamoylornithine N5-carbamylornithine alpha-amino-delta-ureidovaleric acid citrullinationr delta-ureidonorvaline PSI-MOD Deamidated Deamidation MOD:00219 This modification is not the result of deamidation, instead the guanidino group is replaced with an ureido group. L-citrulline MOD:00219 A protein modification that effectively converts an L-arginine residue to L-citrulline. DeltaMass:0 OMSSA:33 PubMed:2466844 RESID:AA0214 Unimod:7#R DiffAvg: 0.98 DiffFormula: C 0 H -1 N -1 O 1 DiffMono: 0.984016 Formula: C 6 H 11 N 3 O 2 MassAvg: 157.17 MassMono: 157.085127 Origin: R Source: natural TermSpec: none Unimod: Unimod:7 (S)-2-amino-5-(carbamoylamino)pentanoic acid 2-amino-5-(aminocarbonyl)aminopentanoic acid Cit Citrulline L-citrulline MOD_RES Citrulline N5-(aminocarbonyl)ornithine N5-carbamoylornithine N5-carbamylornithine alpha-amino-delta-ureidovaleric acid citrullinationr delta-ureidonorvaline Deamidated Deamidated Deamidation A protein modification that effectively converts an L-arginine residue to a 4-hydroxy-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0042 (2S,4Xi)-2-amino-5-[(diaminomethylidene)amino]-4-hydroxypentanoic acid 2-amino-5-(carbamimidamido)-4-hydroxypentanoic acid [tautomer] 2-amino-5-[(aminoiminomethyl)amino]-4-hydroxypentanoic acid [tautomer] 2-amino-5-guanidino-4-hydroxypentanoic acid 4-hydroxy-L-arginine 4-hydroxylated L-arginine 4HyArg C(gamma)-hydroxyarginine MOD_RES 4-hydroxyarginine gamma-hydroxyarginine PSI-MOD MOD:00220 4-hydroxy-L-arginine MOD:00220 A protein modification that effectively converts an L-arginine residue to a 4-hydroxy-L-arginine. PubMed:10966817 PubMed:7650037 RESID:AA0215 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 12 N 4 O 2 MassAvg: 172.19 MassMono: 172.096026 Origin: R Source: natural TermSpec: none (2S,4Xi)-2-amino-5-[(diaminomethylidene)amino]-4-hydroxypentanoic acid 2-amino-5-(carbamimidamido)-4-hydroxypentanoic acid [tautomer] 2-amino-5-[(aminoiminomethyl)amino]-4-hydroxypentanoic acid [tautomer] 2-amino-5-guanidino-4-hydroxypentanoic acid 4-hydroxy-L-arginine 4-hydroxylated L-arginine 4HyArg C(gamma)-hydroxyarginine MOD_RES 4-hydroxyarginine gamma-hydroxyarginine A protein modification that effectively crosslinks L-aspartic acid and L-cysteine residues via an isopeptide bond to form N-(L-isoaspartyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0151 (S)-2-amino-4-((R)-1-carboxy-2-sulfanylethyl)amino-4-oxobutanoic acid 2-(3-amino-3-carboxypropanoyl)amino-3-mercaptopropanoic acid 2-amino-N4-(1-carboxy-2-mercaptoethyl)butanediamic acid CROSSLNK Isoaspartyl cysteine isopeptide (Cys-Asn) N-(L-isoaspartyl)-L-cysteine N-beta-aspartylcysteine N-isoaspartyl cysteine PSI-MOD MOD:00221 Cross-link 2. N-(L-isoaspartyl)-L-cysteine MOD:00221 A protein modification that effectively crosslinks L-aspartic acid and L-cysteine residues via an isopeptide bond to form N-(L-isoaspartyl)-L-cysteine. PubMed:8286361 RESID:AA0216 DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 S 0 DiffMono: -17.026549 Formula: C 7 H 9 N 2 O 3 S 1 MassAvg: 201.22 MassMono: 201.033388 Origin: C, N Source: natural TermSpec: N-term (S)-2-amino-4-((R)-1-carboxy-2-sulfanylethyl)amino-4-oxobutanoic acid 2-(3-amino-3-carboxypropanoyl)amino-3-mercaptopropanoic acid 2-amino-N4-(1-carboxy-2-mercaptoethyl)butanediamic acid CROSSLNK Isoaspartyl cysteine isopeptide (Cys-Asn) N-(L-isoaspartyl)-L-cysteine N-beta-aspartylcysteine N-isoaspartyl cysteine A protein modification that effectively converts an L-tryptophan residue to 2'-alpha-mannosyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0505 (2S)-2-amino-3-(2-beta-D-mannopyranosyl-1H-indol-3-yl)propanoic acid 2'-mannosyl-L-tryptophan 2'-tryptophan C-mannoside C2'ManTrp CARBOHYD C-linked (Man) tryptophan PSI-MOD Hex Hexose MOD:00222 2'-alpha-mannosyl-L-tryptophan MOD:00222 A protein modification that effectively converts an L-tryptophan residue to 2'-alpha-mannosyl-L-tryptophan. PubMed:15279557 PubMed:7547911 PubMed:7947762 RESID:AA0217 Unimod:41#W DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 17 H 20 N 2 O 6 MassAvg: 348.36 MassMono: 348.132136 Origin: W Source: natural TermSpec: none Unimod: Unimod:41 (2S)-2-amino-3-(2-beta-D-mannopyranosyl-1H-indol-3-yl)propanoic acid 2'-mannosyl-L-tryptophan 2'-tryptophan C-mannoside C2'ManTrp CARBOHYD C-linked (Man) tryptophan Hex Hexose A protein modification that effectively converts an L-lysine residue to N6-mureinyl-L-lysine. Origin: Source: TermSpec: uniprot.ptm:PTM-0195 MOD_RES N6-murein peptidoglycan lysine N6-[(2R,6S)-2-(N-(N-mureinyl-(R)-alanyl)-(S)-glutamyl)amino-6-amino-6-carboxy-1-oxohex-1-yl]lysine N6-mureinyl-L-lysine PSI-MOD MOD:00223 N6-mureinyl-L-lysine MOD:00223 A protein modification that effectively converts an L-lysine residue to N6-mureinyl-L-lysine. PubMed:4261992 RESID:AA0218 Origin: K Source: natural TermSpec: none MOD_RES N6-murein peptidoglycan lysine N6-[(2R,6S)-2-(N-(N-mureinyl-(R)-alanyl)-(S)-glutamyl)amino-6-amino-6-carboxy-1-oxohex-1-yl]lysine N6-mureinyl-L-lysine A protein modification that effectively converts an L-aspartic acid residue to 1-chondroitin sulfate-L-aspartic acid ester Origin: TermSpec: uniprot.ptm:PTM-0334 1-aspartic acid ester with 6-chondroitin 4-sulfate 1-chondroitin sulfate-L-aspartic acid ester MOD_RES Aspartate 1-(chondroitin 4-sulfate)-ester poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-6-(1-L-aspartyl)-D-galactose) protein-glycosaminoglycan-protein cross-link PSI-MOD MOD:00224 1-chondroitin sulfate-L-aspartic acid ester MOD:00224 A protein modification that effectively converts an L-aspartic acid residue to 1-chondroitin sulfate-L-aspartic acid ester PubMed:1898736 RESID:AA0219 Origin: D TermSpec: C-term 1-aspartic acid ester with 6-chondroitin 4-sulfate 1-chondroitin sulfate-L-aspartic acid ester MOD_RES Aspartate 1-(chondroitin 4-sulfate)-ester poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-6-(1-L-aspartyl)-D-galactose) protein-glycosaminoglycan-protein cross-link A protein modification that effectively converts an L-cysteine residue to S-(6-FMN)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0271 (R)-2-amino-3-[6-riboflavin 5'-dihydrogen phosphate]sulfanylpropanoic acid 6-[S-cysteinyl]FMN 6-[S-cysteinyl]flavin mononucleotide MOD_RES S-6-FMN cysteine S-(6-FMN)-L-cysteine S6FMNCys PSI-MOD FMNH flavin mononucleotide MOD:00225 S-(6-FMN)-L-cysteine MOD:00225 A protein modification that effectively converts an L-cysteine residue to S-(6-FMN)-L-cysteine. PubMed:10869173 PubMed:1551870 PubMed:620783 RESID:AA0220 Unimod:409#C DiffAvg: 454.33 DiffFormula: C 17 H 19 N 4 O 9 P 1 S 0 DiffMono: 454.088965 Formula: C 20 H 24 N 5 O 10 P 1 S 1 MassAvg: 557.47 MassMono: 557.098150 Origin: C Source: natural TermSpec: none Unimod: Unimod:409 (R)-2-amino-3-[6-riboflavin 5'-dihydrogen phosphate]sulfanylpropanoic acid 6-[S-cysteinyl]FMN 6-[S-cysteinyl]flavin mononucleotide MOD_RES S-6-FMN cysteine S-(6-FMN)-L-cysteine S6FMNCys FMNH flavin mononucleotide A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FAD)-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0288 (S)-2-amino-3-(1-[8alpha riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid 1'-(8alpha-FAD)-L-histidine 8alpha-(N(epsilon)-histidyl)FAD 8alpha-(N1'-histidyl)FAD MOD_RES Tele-8alpha-FAD histidine N theta and N pi-(8alpha-Flavin) (on Histidine) N(tau)-(8alpha-FAD)-histidine Nt8aFADHis tele-(8alpha-FAD)-histidine PSI-MOD 8alpha-N3-histidyl FAD FAD Flavin adenine dinucleotide MOD:00226 From DeltaMass: Average Mass: 784 1'-(8alpha-FAD)-L-histidine MOD:00226 A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FAD)-L-histidine. DeltaMass:0 PubMed:10585424 PubMed:1396672 PubMed:4339951 PubMed:9261083 RESID:AA0221 Unimod:50#H DiffAvg: 783.54 DiffFormula: C 27 H 31 N 9 O 15 P 2 DiffMono: 783.141485 Formula: C 33 H 38 N 12 O 16 P 2 MassAvg: 920.68 MassMono: 920.200396 Origin: H Source: natural TermSpec: none Unimod: Unimod:50 (S)-2-amino-3-(1-[8alpha riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid 1'-(8alpha-FAD)-L-histidine 8alpha-(N(epsilon)-histidyl)FAD 8alpha-(N1'-histidyl)FAD MOD_RES Tele-8alpha-FAD histidine N theta and N pi-(8alpha-Flavin) (on Histidine) N(tau)-(8alpha-FAD)-histidine Nt8aFADHis tele-(8alpha-FAD)-histidine 8alpha-N3-histidyl FAD FAD Flavin adenine dinucleotide A protein modification that effectively converts an L-arginine residue to omega-N-phospho-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0250 (2S)-2-amino-5-(N'-phosphonocarbamimidamido)pentanoic acid (2S)-2-amino-5-([amino(phosphonoamino)methylidene]amino)pentanoic acid MOD_RES Phosphoarginine N(gamma)-phosphoarginine N(omega)-phosphono-L-arginine N5-[imino(phosphonoamino)methyl]-L-ornithine PArg alpha-amino-delta-phosphonoguanidinovaleric acid omega-N-phospho-L-arginine phosphoarginine PSI-MOD Phospho Phosphorylation MOD:00227 omega-N-phospho-L-arginine MOD:00227 A protein modification that effectively converts an L-arginine residue to omega-N-phospho-L-arginine. PubMed:8300603 RESID:AA0222 Unimod:21#R DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 6 H 13 N 4 O 4 P 1 MassAvg: 236.17 MassMono: 236.067442 Origin: R Source: natural TermSpec: none Unimod: Unimod:21 (2S)-2-amino-5-(N'-phosphonocarbamimidamido)pentanoic acid (2S)-2-amino-5-([amino(phosphonoamino)methylidene]amino)pentanoic acid MOD_RES Phosphoarginine N(gamma)-phosphoarginine N(omega)-phosphono-L-arginine N5-[imino(phosphonoamino)methyl]-L-ornithine PArg alpha-amino-delta-phosphonoguanidinovaleric acid omega-N-phospho-L-arginine phosphoarginine Phospho Phosphorylation A protein modification that effectively converts an L-cysteine residue to S-diphytanylglycerol diether-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0273 (2R)-2-amino-3-([(2S)-2,3-bis(3,7,11,15-tetramethylhexadecanyloxy)propyl]sulfanyl)propanoic acid LIPID S-archaeol cysteine S-(diphytanylglyceryl)-L-cysteine S-[2',3'-bis(phytanyloxy)propyl]cysteine S-archaeol cysteine SPhyt2GlyceroCys PSI-MOD Archaeol S-diphytanylglycerol diether MOD:00228 incidental to RESID:AA0043. S-diphytanylglycerol diether-L-cysteine MOD:00228 A protein modification that effectively converts an L-cysteine residue to S-diphytanylglycerol diether-L-cysteine. PubMed:7797461 PubMed:8195126 RESID:AA0223 Unimod:410 DiffAvg: 635.16 DiffFormula: C 43 H 86 N 0 O 2 S 0 DiffMono: 634.662782 Formula: C 46 H 91 N 1 O 3 S 1 MassAvg: 738.30 MassMono: 737.671967 Origin: C Source: natural TermSpec: none Unimod: Unimod:410 (2R)-2-amino-3-([(2S)-2,3-bis(3,7,11,15-tetramethylhexadecanyloxy)propyl]sulfanyl)propanoic acid LIPID S-archaeol cysteine S-(diphytanylglyceryl)-L-cysteine S-[2',3'-bis(phytanyloxy)propyl]cysteine S-archaeol cysteine SPhyt2GlyceroCys Archaeol S-diphytanylglycerol diether A protein modification that effectively converts two L-cysteine residues to form alpha-1-microglobulin-Ig alpha complex chromophore. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: BINDING Multimeric 3-hydroxykynurenine chromophore (covalent) alpha-1-microglobulin-Ig alpha complex chromophore PSI-MOD MOD:00229 Cross-link 2. alpha-1-microglobulin-Ig alpha complex chromophore MOD:00229 A protein modification that effectively converts two L-cysteine residues to form alpha-1-microglobulin-Ig alpha complex chromophore. PubMed:11058759 PubMed:11877257 PubMed:7506257 PubMed:7535251 RESID:AA0224 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 6 H 8 N 2 O 2 S 2 MassAvg: 204.26 MassMono: 204.002720 Origin: C, C Source: natural TermSpec: none BINDING Multimeric 3-hydroxykynurenine chromophore (covalent) alpha-1-microglobulin-Ig alpha complex chromophore A protein modification that effectively converts two L-cysteine residues, two L-histidine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bis-L-histidino diiron disulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (2Fe-2S) METAL Iron-sulfur (2Fe-2S); via pros nitrogen Rieske iron-sulfur cofactor bis-L-cysteinyl bis-L-histidino diiron disulfide di-mu-sulfido(bis-S-cysteinyliron)(bis-N3'-histidinoiron) PSI-MOD MOD:00230 Cross-link 4. bis-L-cysteinyl bis-L-histidino diiron disulfide MOD:00230 A protein modification that effectively converts two L-cysteine residues, two L-histidine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bis-L-histidino diiron disulfide. PubMed:2765515 PubMed:9651245 RESID:AA0225 DiffAvg: 171.78 DiffFormula: C 0 Fe 2 H -4 N 0 O 0 S 2 DiffMono: 171.783814 FormalCharge: 2- Formula: C 18 Fe 2 H 20 N 8 O 4 S 4 MassAvg: 652.34 MassMono: 651.920007 Origin: C, C, H, H Source: natural TermSpec: none METAL Iron-sulfur (2Fe-2S) METAL Iron-sulfur (2Fe-2S); via pros nitrogen Rieske iron-sulfur cofactor bis-L-cysteinyl bis-L-histidino diiron disulfide di-mu-sulfido(bis-S-cysteinyliron)(bis-N3'-histidinoiron) A protein modification that effectively converts six L-cysteine residues and a six-iron six-sulfur cluster to hexakis-L-cysteinyl hexairon hexasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: hexa-mu3-sulfido-hexakis(S-cysteinyliron) hexa-mu3-sulfido-hexakis(cysteinato-kappaS)-hexairon hexakis-L-cysteinyl hexairon hexasulfide prismane iron-sulfur cofactor PSI-MOD MOD:00231 Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. hexakis-L-cysteinyl hexairon hexasulfide MOD:00231 A protein modification that effectively converts six L-cysteine residues and a six-iron six-sulfur cluster to hexakis-L-cysteinyl hexairon hexasulfide. PubMed:1311311 PubMed:1318833 RESID:AA0226 DiffAvg: 521.38 DiffFormula: C 0 Fe 6 H -6 N 0 O 0 S 6 DiffMono: 521.395649 FormalCharge: 1- Formula: C 18 Fe 6 H 24 N 6 O 6 S 12 MassAvg: 1140.22 MassMono: 1139.450758 Origin: C, C, C, C, C, C Source: hypothetical TermSpec: none hexa-mu3-sulfido-hexakis(S-cysteinyliron) hexa-mu3-sulfido-hexakis(cysteinato-kappaS)-hexairon hexakis-L-cysteinyl hexairon hexasulfide prismane iron-sulfur cofactor A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form N6-(phospho-5'-adenosine)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-6-(5'-adenosine phosphonamino)hexanoic acid 5'-adenylic-N6-L-lysine ACT_SITE N6-AMP-lysine intermediate AMP Lysyl L-lysine monoanhydride with 5'-adenylic acid N(zeta)-5'-adenylic-L-lysine N6-(phospho-5'-adenosine)-L-lysine N6-L-lysine 5'-adenosine phosphoramidester N6AMPLys epsilon-5'-adenylic-L-lysine PSI-MOD AMP binding site Phosphoadenosine MOD:00232 N6-(phospho-5'-adenosine)-L-lysine MOD:00232 A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form N6-(phospho-5'-adenosine)-L-lysine. DeltaMass:316 PubMed:3882425 PubMed:4944632 RESID:AA0227 Unimod:405#K DiffAvg: 329.21 DiffFormula: C 10 H 12 N 5 O 6 P 1 DiffMono: 329.052520 Formula: C 16 H 24 N 7 O 7 P 1 MassAvg: 457.38 MassMono: 457.147483 Origin: K Source: natural TermSpec: none Unimod: Unimod:405 (2S)-2-amino-6-(5'-adenosine phosphonamino)hexanoic acid 5'-adenylic-N6-L-lysine ACT_SITE N6-AMP-lysine intermediate AMP Lysyl L-lysine monoanhydride with 5'-adenylic acid N(zeta)-5'-adenylic-L-lysine N6-(phospho-5'-adenosine)-L-lysine N6-L-lysine 5'-adenosine phosphoramidester N6AMPLys epsilon-5'-adenylic-L-lysine AMP binding site Phosphoadenosine A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoguanosine through a phosphoramide ester bond to form N6-(phospho-5'-guanosine)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-6-(5'-guanosine phosphonamino)hexanoic acid 5'-guanylic-N6-L-lysine 5'phos Guanosyl ACT_SITE N6-GMP-lysine intermediate L-lysine monoanhydride with 5'-guanylic acid N(zeta)-5'-guanylic-lysine N6-(5'-guanylyl)-lysine N6-(phospho-5'-guanosine)-L-lysine N6-L-lysine 5'-guanosine phosphoramidester N6GMPLys epsilon-5'-guanylic-L-lysine lysine guanosine-5'-monophosphate PSI-MOD Phosphoguanosine phospho-guanosine MOD:00233 From DeltaMass: Average Mass: 345 Formula:C10H12O5N7P1 Monoisotopic Mass Change:345.047 Average Mass Change:345.209 References:PE Sciex N6-(phospho-5'-guanosine)-L-lysine MOD:00233 A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoguanosine through a phosphoramide ester bond to form N6-(phospho-5'-guanosine)-L-lysine. DeltaMass:304 PubMed:6092377 PubMed:6264433 RESID:AA0228 Unimod:413#K DiffAvg: 345.21 DiffFormula: C 10 H 12 N 5 O 7 P 1 DiffMono: 345.047434 Formula: C 16 H 24 N 7 O 8 P 1 MassAvg: 473.38 MassMono: 473.142397 Origin: K Source: natural TermSpec: none Unimod: Unimod:413 (2S)-2-amino-6-(5'-guanosine phosphonamino)hexanoic acid 5'-guanylic-N6-L-lysine 5'phos Guanosyl ACT_SITE N6-GMP-lysine intermediate L-lysine monoanhydride with 5'-guanylic acid N(zeta)-5'-guanylic-lysine N6-(5'-guanylyl)-lysine N6-(phospho-5'-guanosine)-L-lysine N6-L-lysine 5'-guanosine phosphoramidester N6GMPLys epsilon-5'-guanylic-L-lysine lysine guanosine-5'-monophosphate Phosphoguanosine phospho-guanosine A protein modification that effectively converts an L-cysteine residue to S-glutathionyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0311 (2S)-2-amino-3-((2S)-2-((4R)-4-amino-4-carboxyl-1-oxobutyl)amino-3-(carboxylmethyl)amino-3-oxo-propyl)dithio-propanoic acid Glutathionation L-cysteine glutathione disulfide L-gamma-glutamyl-L-cysteinyl-glycine (2-1')-disulfide with L-cysteine MOD_RES S-glutathionyl cysteine N-(N-gamma-glutamyl-cystinyl)-glycine SGltCys cysteinyl glutathione glutathionec PSI-MOD Glutathione glutathione disulfide MOD:00234 From DeltaMass: Average Mass: 305 Glutamyl-transpeptidase cleaves glutathione into cysteinylglycine (Cys-Gly) and a Glu residue. [PubMed: 28537416] L-cysteine glutathione disulfide MOD:00234 A protein modification that effectively converts an L-cysteine residue to S-glutathionyl-L-cysteine. ChEBI:21264 DeltaMass:0 OMSSA:51 PubMed:3083866 PubMed:8344916 RESID:AA0229 Unimod:55 DiffAvg: 305.30 DiffFormula: C 10 H 15 N 3 O 6 S 1 DiffMono: 305.068156 Formula: C 13 H 20 N 4 O 7 S 2 MassAvg: 408.44 MassMono: 408.077341 Origin: C Source: natural TermSpec: none Unimod: Unimod:55 (2S)-2-amino-3-((2S)-2-((4R)-4-amino-4-carboxyl-1-oxobutyl)amino-3-(carboxylmethyl)amino-3-oxo-propyl)dithio-propanoic acid Glutathionation L-cysteine glutathione disulfide L-gamma-glutamyl-L-cysteinyl-glycine (2-1')-disulfide with L-cysteine MOD_RES S-glutathionyl cysteine N-(N-gamma-glutamyl-cystinyl)-glycine SGltCys cysteinyl glutathione glutathionec Glutathione glutathione disulfide A protein modification that effectively converts an L-cysteine residue to S-nitrosyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0280 (2R)-2-amino-3-nitrososulfanyl-propanoic acid L-cysteine nitrite ester MOD_RES S-nitrosocysteine S-nitrosocysteine S-nitrosyl-L-cysteine SNOCys PSI-MOD Nitrosyl S-nitrosylation MOD:00235 S-nitrosyl-L-cysteine MOD:00235 A protein modification that effectively converts an L-cysteine residue to S-nitrosyl-L-cysteine. PubMed:10442087 PubMed:11562475 PubMed:15688001 PubMed:8626764 PubMed:8637569 RESID:AA0230 Unimod:275 DiffAvg: 29.00 DiffFormula: C 0 H -1 N 1 O 1 S 0 DiffMono: 28.990164 Formula: C 3 H 4 N 2 O 2 S 1 MassAvg: 132.14 MassMono: 131.999348 Origin: C Source: natural TermSpec: none Unimod: Unimod:275 (2R)-2-amino-3-nitrososulfanyl-propanoic acid L-cysteine nitrite ester MOD_RES S-nitrosocysteine S-nitrosocysteine S-nitrosyl-L-cysteine SNOCys Nitrosyl S-nitrosylation A protein modification that effectively converts an L-asparagine residue to N4-(ADP-ribosyl)-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0054 (S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-4-oxobutanoic acid MOD_RES ADP-ribosylasparagine N4-(ADP-ribosyl)-L-asparagine N4-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-asparagine N4-alpha-D-ribofuranosyl-L-asparagine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) PSI-MOD ADP Ribose addition ADP-Ribosyl MOD:00236 N4-(ADP-ribosyl)-L-asparagine MOD:00236 A protein modification that effectively converts an L-asparagine residue to N4-(ADP-ribosyl)-L-asparagine. PubMed:15842200 PubMed:2498316 RESID:AA0231 Unimod:213#N DiffAvg: 541.30 DiffFormula: C 15 H 21 N 5 O 13 P 2 DiffMono: 541.061109 Formula: C 19 H 27 N 7 O 15 P 2 MassAvg: 655.41 MassMono: 655.104036 Origin: N Source: natural TermSpec: none Unimod: Unimod:213 (S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-4-oxobutanoic acid MOD_RES ADP-ribosylasparagine N4-(ADP-ribosyl)-L-asparagine N4-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-asparagine N4-alpha-D-ribofuranosyl-L-asparagine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) ADP Ribose addition ADP-Ribosyl A protein modification that effectively converts an L-aspartic acid residue to L-beta-methylthioaspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0032 (2R,3Xi)-2-amino-3-(methylsulfanyl)butanedioic acid 3-(methylthio)-L-aspartic acid 3-carboxy-S-methyl-cysteine 3-methylthio-aspartic acid 3MeSAsp MOD_RES 3-methylthioaspartic acid beta-Methylthio-aspartic acid beta-methylthio-aspartic acid bmethylthiold methythiold PSI-MOD Beta-methylthiolation Methylthio MOD:00237 L-beta-methylthioaspartic acid MOD:00237 A protein modification that effectively converts an L-aspartic acid residue to L-beta-methylthioaspartic acid. ChEBI:73599 DeltaMass:61 OMSSA:13 OMSSA:26 PubMed:15473684 PubMed:8844851 RESID:AA0232 Unimod:39#D DiffAvg: 46.09 DiffFormula: C 1 H 2 N 0 O 0 S 1 DiffMono: 45.987721 Formula: C 5 H 7 N 1 O 3 S 1 MassAvg: 161.18 MassMono: 161.014664 Origin: D Source: natural TermSpec: none Unimod: Unimod:39 (2R,3Xi)-2-amino-3-(methylsulfanyl)butanedioic acid 3-(methylthio)-L-aspartic acid 3-carboxy-S-methyl-cysteine 3-methylthio-aspartic acid 3MeSAsp MOD_RES 3-methylthioaspartic acid beta-Methylthio-aspartic acid beta-methylthio-aspartic acid bmethylthiold methythiold Beta-methylthiolation Methylthio A protein modification that effectively cross-links an L-lysine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 5'-(N6-L-lysine)-L-topaquinone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0171 1-[(S)-5-amino-5-carboxypentyl]amino-2-[(S)-2-amino-2-carboxyethyl]-2,6-cyclohexadien-4,5-dione 2'-(L-lys-N6-yl)-L-4',5'-topaquinone 2'-(L-lysine)-L-tyrosyl-4',5'-quinone CROSSLNK Lysine tyrosylquinone (Lys-Tyr) CROSSLNK Lysine tyrosylquinone (Tyr-Lys) LTQ lysyl oxidase cofactor PSI-MOD MOD:00238 Cross-link 2; secondary to RESID:AA0147. 5'-(N6-L-lysine)-L-topaquinone MOD:00238 A protein modification that effectively cross-links an L-lysine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 5'-(N6-L-lysine)-L-topaquinone. PubMed:8688089 RESID:AA0233 DiffAvg: 11.97 DiffFormula: C 0 H -4 N 0 O 1 DiffMono: 11.963614 Formula: C 15 H 17 N 3 O 4 MassAvg: 303.32 MassMono: 303.121906 Origin: K, Y Source: natural TermSpec: none 1-[(S)-5-amino-5-carboxypentyl]amino-2-[(S)-2-amino-2-carboxyethyl]-2,6-cyclohexadien-4,5-dione 2'-(L-lys-N6-yl)-L-4',5'-topaquinone 2'-(L-lysine)-L-tyrosyl-4',5'-quinone CROSSLNK Lysine tyrosylquinone (Lys-Tyr) CROSSLNK Lysine tyrosylquinone (Tyr-Lys) LTQ lysyl oxidase cofactor A protein modification that effectively converts an L-cysteine residue to S-methyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0636 (R)-2-amino-3-(methylsulfanyl)propanoic acid ACT_SITE S-methylcysteine intermediate L-3-(methylthio)alanine MOD_RES S-methylcysteine S-methyl-L-cysteine S-methylated L-cysteine SMeCys PSI-MOD Methyl Methylation MOD:00239 S-methyl-L-cysteine MOD:00239 A protein modification that effectively converts an L-cysteine residue to S-methyl-L-cysteine. PubMed:10660523 PubMed:11875433 PubMed:1339288 RESID:AA0234 Unimod:34#C DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 S 0 DiffMono: 14.015650 Formula: C 4 H 7 N 1 O 1 S 1 MassAvg: 117.17 MassMono: 117.024835 Origin: C Source: natural TermSpec: none Unimod: Unimod:34 (R)-2-amino-3-(methylsulfanyl)propanoic acid ACT_SITE S-methylcysteine intermediate L-3-(methylthio)alanine MOD_RES S-methylcysteine S-methyl-L-cysteine S-methylated L-cysteine SMeCys Methyl Methylation A protein modification that effectively converts an L-lysine residue to 4-hydroxy-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0664 (2S,4R)-2,6-diamino-4-hydroxyhexanoic acid 4-hydroxy-L-lysine 4-hydroxylated L-lysine 4HyLys L-threo-gamma-hydroxylysine MOD_RES 4-hydroxylysine alpha,epsilon-diamino-gamma-hydroxycaproic acid PSI-MOD MOD:00240 This modification was not structurally confirmed. Later 5-hydroxy-L-lysine was found at a homologous position in the same protein from closely related species. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. 4-hydroxy-L-lysine MOD:00240 A protein modification that effectively converts an L-lysine residue to 4-hydroxy-L-lysine. ChEBI:141495 PubMed:4005040 RESID:AA0235 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 12 N 2 O 2 MassAvg: 144.17 MassMono: 144.089878 Origin: K Source: artifact TermSpec: none (2S,4R)-2,6-diamino-4-hydroxyhexanoic acid 4-hydroxy-L-lysine 4-hydroxylated L-lysine 4HyLys L-threo-gamma-hydroxylysine MOD_RES 4-hydroxylysine alpha,epsilon-diamino-gamma-hydroxycaproic acid A protein modification that effectively converts an L-asparagine residue to N4-hydroxymethyl-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-4-[(hydroxymethyl)amino]-4-oxobutanoic acid 2-amino-N4-hydroxymethylbutanediamic acid N(gamma)-hydroxymethylasparagine N4-hydroxymethyl-L-asparagine N4-hydroxymethylasparagine beta-hydroxymethylasparagine PSI-MOD Hydroxymethyl hydroxymethyl MOD:00241 N4-methyl-L-asparagine, see MOD:0079, was found at a homologous position of the same protein in a closely related species. Since the peptide containing this modification was obtained by enzymatic cleavage, not cyanogen bromide cleavage, it could have experienced oxidation of the following methionine residue, leading to the erroneous attribution of a mass of 29 for the modification rather than 14. comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. N4-hydroxymethyl-L-asparagine MOD:00241 A protein modification that effectively converts an L-asparagine residue to N4-hydroxymethyl-L-asparagine. RESID:AA0236 Unimod:414 DiffAvg: 30.03 DiffFormula: C 1 H 2 N 0 O 1 DiffMono: 30.010565 Formula: C 5 H 8 N 2 O 3 MassAvg: 144.13 MassMono: 144.053492 Origin: N Source: artifact TermSpec: none Unimod: Unimod:414 (2S)-2-amino-4-[(hydroxymethyl)amino]-4-oxobutanoic acid 2-amino-N4-hydroxymethylbutanediamic acid N(gamma)-hydroxymethylasparagine N4-hydroxymethyl-L-asparagine N4-hydroxymethylasparagine beta-hydroxymethylasparagine Hydroxymethyl hydroxymethyl A protein modification that effectively converts an L-serine residue to O-(ADP-ribosyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0056 (S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-propanoic acid MOD_RES ADP-ribosylserine O-(ADP-ribosyl)-L-serine O3-(ADP-ribosyl)-L-serine O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-serine O3-alpha-D-ribofuranosyl-L-serine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) OADPRibSer PSI-MOD ADP Ribose addition ADP-Ribosyl MOD:00242 O-(ADP-ribosyl)-L-serine MOD:00242 A protein modification that effectively converts an L-serine residue to O-(ADP-ribosyl)-L-serine. PubMed:15842200 PubMed:3141412 RESID:AA0237 Unimod:213#S DiffAvg: 541.30 DiffFormula: C 15 H 21 N 5 O 13 P 2 DiffMono: 541.061109 Formula: C 18 H 26 N 6 O 15 P 2 MassAvg: 628.38 MassMono: 628.093137 Origin: S Source: natural TermSpec: none Unimod: Unimod:213 (S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-propanoic acid MOD_RES ADP-ribosylserine O-(ADP-ribosyl)-L-serine O3-(ADP-ribosyl)-L-serine O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-serine O3-alpha-D-ribofuranosyl-L-serine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) OADPRibSer ADP Ribose addition ADP-Ribosyl A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0376 2-(1-azanyl-2-sulfanylethyl)-4-oxazolecarboxylic acid 2-[(1R)-1-amino-2-sulfanylethyl]-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazole-4-carboxylic acid (Cys-Ser) L-cysteine oxazole-4-carboxylic acid PSI-MOD MOD:00243 Cross-link 2. L-cysteine oxazole-4-carboxylic acid MOD:00243 A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid. PubMed:8183941 PubMed:8895467 RESID:AA0238 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 6 H 6 N 2 O 2 S 1 MassAvg: 170.19 MassMono: 170.014998 Origin: C, S Source: natural TermSpec: none 2-(1-azanyl-2-sulfanylethyl)-4-oxazolecarboxylic acid 2-[(1R)-1-amino-2-sulfanylethyl]-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazole-4-carboxylic acid (Cys-Ser) L-cysteine oxazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazoline-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0381 (4S)-2-[(1R)-1-amino-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid 2-[1-azanyl-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazoline-4-carboxylic acid (Cys-Ser) L-cysteine oxazoline-4-carboxylic acid PSI-MOD MOD:00244 Cross-link 2. L-cysteine oxazoline-4-carboxylic acid MOD:00244 A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazoline-4-carboxylic acid. PubMed:1880060 RESID:AA0239 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 6 H 8 N 2 O 2 S 1 MassAvg: 172.20 MassMono: 172.030649 Origin: C, S Source: natural TermSpec: none (4S)-2-[(1R)-1-amino-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid 2-[1-azanyl-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazoline-4-carboxylic acid (Cys-Ser) L-cysteine oxazoline-4-carboxylic acid A protein modification that effectively crosslinks a glycine residue and an L-serine residue to form glycine oxazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0377 2-aminomethyl-1,3-oxazole-4-carboxylic acid 2-azanylmethyl-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazole-4-carboxylic acid (Gly-Ser) glycine oxazole-4-carboxylic acid PSI-MOD MOD:00245 Cross-link 2. glycine oxazole-4-carboxylic acid MOD:00245 A protein modification that effectively crosslinks a glycine residue and an L-serine residue to form glycine oxazole-4-carboxylic acid. PubMed:8183941 PubMed:8895467 RESID:AA0240 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 DiffMono: -20.026215 Formula: C 5 H 4 N 2 O 2 MassAvg: 124.10 MassMono: 124.027277 Origin: G, S Source: natural TermSpec: none 2-aminomethyl-1,3-oxazole-4-carboxylic acid 2-azanylmethyl-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazole-4-carboxylic acid (Gly-Ser) glycine oxazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form glycine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0378 2-(aminomethyl)-1,3-thiazole-4-carboxylic acid 2-(azanylmethyl)-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Gly-Cys) glycine thiazole-4-carboxylic acid PSI-MOD MOD:00246 Cross-link 2. glycine thiazole-4-carboxylic acid MOD:00246 A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form glycine thiazole-4-carboxylic acid. ChEBI:21276 PubMed:8183941 PubMed:8895467 RESID:AA0241 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 5 H 4 N 2 O 1 S 1 MassAvg: 140.16 MassMono: 140.004434 Origin: C, G Source: natural TermSpec: none 2-(aminomethyl)-1,3-thiazole-4-carboxylic acid 2-(azanylmethyl)-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Gly-Cys) glycine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-serine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0363 2-[(1S)-1-amino-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Ser-Cys) L-serine thiazole-4-carboxylic acid PSI-MOD MOD:00247 Cross-link 2. L-serine thiazole-4-carboxylic acid MOD:00247 A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-serine thiazole-4-carboxylic acid. PubMed:8183941 PubMed:8895467 RESID:AA0242 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 6 H 6 N 2 O 2 S 1 MassAvg: 170.19 MassMono: 170.014998 Origin: C, S Source: natural TermSpec: none 2-[(1S)-1-amino-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Ser-Cys) L-serine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0375 2-[(1S)-1-amino-2-phenylethyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-phenylethyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Phe-Cys) L-phenylalanine thiazole-4-carboxylic acid PSI-MOD MOD:00248 Cross-link 2. L-phenylalanine thiazole-4-carboxylic acid MOD:00248 A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazole-4-carboxylic acid. PubMed:1880060 RESID:AA0243 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 12 H 10 N 2 O 1 S 1 MassAvg: 230.29 MassMono: 230.051384 Origin: C, F Source: natural TermSpec: none 2-[(1S)-1-amino-2-phenylethyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-phenylethyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Phe-Cys) L-phenylalanine thiazole-4-carboxylic acid A protein modification that effectively crosslinks two L-cysteine residues to form L-cysteine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0360 2-[(1S)-1-amino-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Cys-Cys) L-cysteine thiazole-4-carboxylic acid PSI-MOD MOD:00249 Cross-link 2. L-cysteine thiazole-4-carboxylic acid MOD:00249 A protein modification that effectively crosslinks two L-cysteine residues to form L-cysteine thiazole-4-carboxylic acid. PubMed:1880060 RESID:AA0244 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 6 H 6 N 2 O 1 S 2 MassAvg: 186.25 MassMono: 185.992155 Origin: C, C Source: natural TermSpec: none 2-[(1S)-1-amino-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Cys-Cys) L-cysteine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to form L-lysine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-[(1S)-1,5-diaminopentyl]-1,3-thiazole-4-carboxylic acid 2-[1,5-bis(azanyl)pentyl]-1,3-thiazole-4-carboxylic acid L-lysine thiazole-4-carboxylic acid PSI-MOD MOD:00250 Cross-link 2. Lysine is now thought not to be encoded in the peptide sequence modified to produce GE2270. See RESID:AA0470. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. L-lysine thiazole-4-carboxylic acid MOD:00250 A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to form L-lysine thiazole-4-carboxylic acid. PubMed:1880060 RESID:AA0245 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 9 H 13 N 3 O 1 S 1 MassAvg: 211.28 MassMono: 211.077933 Origin: C, K Source: hypothetical TermSpec: none 2-[(1S)-1,5-diaminopentyl]-1,3-thiazole-4-carboxylic acid 2-[1,5-bis(azanyl)pentyl]-1,3-thiazole-4-carboxylic acid L-lysine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-serine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-serine. Origin: Source: TermSpec: uniprot.ptm:PTM-0226 (S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)propanoic acid ACT_SITE O-(5'-phospho-DNA)-serine intermediate MOD_RES O-(5'-phospho-DNA)-serine O-(phospho-5'-DNA)-L-serine O3-(phospho-5'-DNA)-L-serine O3-L-serine 5'-DNA phosphodiester PSI-MOD MOD:00251 O-(phospho-5'-DNA)-L-serine MOD:00251 A protein modification that effectively crosslinks an L-serine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-serine. PubMed:7142163 PubMed:7265205 RESID:AA0246 Origin: S Source: natural TermSpec: none (S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)propanoic acid ACT_SITE O-(5'-phospho-DNA)-serine intermediate MOD_RES O-(5'-phospho-DNA)-serine O-(phospho-5'-DNA)-L-serine O3-(phospho-5'-DNA)-L-serine O3-L-serine 5'-DNA phosphodiester A protein modification that effectively cross-links an L-threonine residue to the polymer keratan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. Origin: Source: TermSpec: keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine keratosulfate poly[beta-1,4-(2-acetamido-2-deoxy-6-sulfate D-glucosyl)-beta-1,3-D-galactosyl]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-threonine PSI-MOD MOD:00252 keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine MOD:00252 A protein modification that effectively cross-links an L-threonine residue to the polymer keratan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide. PubMed:1417734 PubMed:3472204 RESID:AA0247 Origin: T Source: natural TermSpec: none keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine keratosulfate poly[beta-1,4-(2-acetamido-2-deoxy-6-sulfate D-glucosyl)-beta-1,3-D-galactosyl]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-threonine A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:00253 L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Sec) MOD:00253 A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide). PubMed:14235557 PubMed:2211698 PubMed:8052647 PubMed:9036855 RESID:AA0248#SEC Unimod:415 DiffAvg: 1572.02 DiffFormula: C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 Se 0 DiffMono: 1572.985775 Formula: C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1 MassAvg: 1722.07 MassMono: 1723.939410 Origin: U Source: natural TermSpec: none Unimod: Unimod:415 A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-tyrosine. Origin: Source: TermSpec: uniprot.ptm:PTM-0229 (S)-2-amino-3-[4-(5'-ribonucleic acid phosphonoxy)phenyl]propanoic acid MOD_RES O-(5'-phospho-RNA)-tyrosine O4'-(phospho-5'-RNA)-L-tyrosine O4'-L-tyrosine 5'-RNA phosphodiester PSI-MOD MOD:00254 O4'-(phospho-5'-RNA)-L-tyrosine MOD:00254 A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-tyrosine. PubMed:1702164 PubMed:209034 PubMed:217003 PubMed:6264310 RESID:AA0249 Origin: Y Source: natural TermSpec: none (S)-2-amino-3-[4-(5'-ribonucleic acid phosphonoxy)phenyl]propanoic acid MOD_RES O-(5'-phospho-RNA)-tyrosine O4'-(phospho-5'-RNA)-L-tyrosine O4'-L-tyrosine 5'-RNA phosphodiester A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3-(3'-L-histidyl)-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0027 (2S,3R)-2-amino-3-(5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid 3-(3'-L-histidyl)-L-tyrosine 3-(N3'-histidyl)tyrosine 3-(pi-histidyl)tyrosine 3-(pros-histidyl)tyrosine CROSSLNK 3'-histidyl-3-tyrosine (His-Tyr) beta-(N(delta)-histidyl)tyrosine beta-(N3'-histidyl)tyrosine PSI-MOD MOD:00255 Cross-link 2. 3-(3'-L-histidyl)-L-tyrosine MOD:00255 A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3-(3'-L-histidyl)-L-tyrosine. PubMed:9144772 RESID:AA0250 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 15 H 14 N 4 O 3 MassAvg: 298.30 MassMono: 298.106590 Origin: H, Y Source: natural TermSpec: none (2S,3R)-2-amino-3-(5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid 3-(3'-L-histidyl)-L-tyrosine 3-(N3'-histidyl)tyrosine 3-(pi-histidyl)tyrosine 3-(pros-histidyl)tyrosine CROSSLNK 3'-histidyl-3-tyrosine (His-Tyr) beta-(N(delta)-histidyl)tyrosine beta-(N3'-histidyl)tyrosine A protein modification that dioxygenates an L-methionine residue to L-methionine sulfone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0175 (2S)-2-amino-4-(methylsulfonyl)butanoic acid L-methionine S,S-dioxide L-methionine sulfone MOD_RES Methionine sulfone MetO2 MethionylSulphone Oxidation of Methionine (to Sulphone) S,S-dioxymethionine suphonem PSI-MOD Dioxidation dihydroxy MOD:00256 DeltaMass gives the formula C 5 H 9 N 3 O 1 S 1 with mass 163 L-methionine sulfone MOD:00256 A protein modification that dioxygenates an L-methionine residue to L-methionine sulfone. DeltaMass:205 OMSSA:115 PubMed:12686488 PubMed:7786407 PubMed:7791219 PubMed:9252331 RESID:AA0251 Unimod:425#M DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 S 0 DiffMono: 31.989829 Formula: C 5 H 9 N 1 O 3 S 1 MassAvg: 163.19 MassMono: 163.030314 Origin: M Source: natural TermSpec: none Unimod: Unimod:425 (2S)-2-amino-4-(methylsulfonyl)butanoic acid L-methionine S,S-dioxide L-methionine sulfone MOD_RES Methionine sulfone MetO2 MethionylSulphone Oxidation of Methionine (to Sulphone) S,S-dioxymethionine suphonem Dioxidation dihydroxy A protein modification that effectively converts an L-cysteine residue to dipyrrolylmethanemethyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0421 (2S)-3-[5-[4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methyl-4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid 3-[5-(3-acetic acid-4-propanoic acid-1-pyrrol-2-yl)methyl-3-acetic acid-4-propanoic acid-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid MOD_RES S-(dipyrrolylmethanemethyl)cysteine dipyrrole cofactor dipyrrolylmethanemethyl-L-cysteine dipyrrolylmethyl-L-cysteine dipyrromethane cofactor pyrromethane cofactor PSI-MOD Dipyrrolylmethanemethyl dipyrrolylmethanemethyl MOD:00257 dipyrrolylmethanemethyl-L-cysteine MOD:00257 A protein modification that effectively converts an L-cysteine residue to dipyrrolylmethanemethyl-L-cysteine. PubMed:3042456 PubMed:3196304 PubMed:3421931 PubMed:8727319 RESID:AA0252 Unimod:416 DiffAvg: 418.40 DiffFormula: C 20 H 22 N 2 O 8 S 0 DiffMono: 418.137616 Formula: C 23 H 27 N 3 O 9 S 1 MassAvg: 521.54 MassMono: 521.146800 Origin: C Source: natural TermSpec: none Unimod: Unimod:416 (2S)-3-[5-[4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methyl-4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid 3-[5-(3-acetic acid-4-propanoic acid-1-pyrrol-2-yl)methyl-3-acetic acid-4-propanoic acid-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid MOD_RES S-(dipyrrolylmethanemethyl)cysteine dipyrrole cofactor dipyrrolylmethanemethyl-L-cysteine dipyrrolylmethyl-L-cysteine dipyrromethane cofactor pyrromethane cofactor Dipyrrolylmethanemethyl dipyrrolylmethanemethyl A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form S-(2-aminovinyl)-3-methyl-D-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0267 (2S,3S)-2-amino-3-[((Z)-2-aminoethenyl)sulfanyl]butanoic acid 2-amino-3-[(2-aminovinyl)sulfanyl]butanoic acid CROSSLNK S-(2-aminovinyl)-3-methyl-D-cysteine (Thr-Cys) S-(2-aminovinyl)-3-methyl-D-cysteine decarboxylated methyllanthionine PSI-MOD MOD:00258 Cross-link 2. S-(2-aminovinyl)-3-methyl-D-cysteine MOD:00258 A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form S-(2-aminovinyl)-3-methyl-D-cysteine. PubMed:9119018 RESID:AA0253 DiffAvg: -64.04 DiffFormula: C -1 H -4 N 0 O -3 S 0 DiffMono: -64.016044 Formula: C 6 H 9 N 2 O 1 S 1 MassAvg: 157.21 MassMono: 157.043559 Origin: C, T Source: natural TermSpec: C-term (2S,3S)-2-amino-3-[((Z)-2-aminoethenyl)sulfanyl]butanoic acid 2-amino-3-[(2-aminovinyl)sulfanyl]butanoic acid CROSSLNK S-(2-aminovinyl)-3-methyl-D-cysteine (Thr-Cys) S-(2-aminovinyl)-3-methyl-D-cysteine decarboxylated methyllanthionine A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of DNA through a phosphodiester bond to form O4'-(phospho-5'-DNA)-L-tyrosine. Origin: Source: TermSpec: uniprot.ptm:PTM-0228 (S)-2-amino-3-[4-(5'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid ACT_SITE O-(5'-phospho-DNA)-tyrosine intermediate MOD_RES O-(5'-phospho-DNA)-tyrosine O4'-(phospho-5'-DNA)-L-tyrosine O4'-L-tyrosine 5'-DNA phosphodiester PSI-MOD MOD:00259 O4'-(phospho-5'-DNA)-L-tyrosine MOD:00259 A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of DNA through a phosphodiester bond to form O4'-(phospho-5'-DNA)-L-tyrosine. PubMed:1861973 PubMed:2940511 PubMed:3684578 RESID:AA0254 Origin: Y Source: natural TermSpec: none (S)-2-amino-3-[4-(5'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid ACT_SITE O-(5'-phospho-DNA)-tyrosine intermediate MOD_RES O-(5'-phospho-DNA)-tyrosine O4'-(phospho-5'-DNA)-L-tyrosine O4'-L-tyrosine 5'-DNA phosphodiester A protein modification that effectively crosslinks an L-threonine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)butanoic acid O-(phospho-5'-DNA)-L-threonine O3-(phospho-5'-DNA)-L-threonine O3-L-threonine 5'-DNA phosphodiester PSI-MOD MOD:00260 O-(phospho-5'-DNA)-L-threonine MOD:00260 A protein modification that effectively crosslinks an L-threonine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-threonine. PubMed:3081736 RESID:AA0255 DiffAvg: 78.97 DiffFormula: C 0 H 0 N 0 O 3 P 1 DiffMono: 78.958505 Formula: C 4 H 7 N 1 O 5 P 1 MassAvg: 180.08 MassMono: 180.006184 Origin: T Source: natural TermSpec: none (S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)butanoic acid O-(phospho-5'-DNA)-L-threonine O3-(phospho-5'-DNA)-L-threonine O3-L-threonine 5'-DNA phosphodiester A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphouridine through a phosphodiester bond to form O4'-(phospho-5'-uridine)-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0333 (S)-2-amino-3-[4-(5'-uridine phosphonoxy)phenyl]propanoic acid 5'-uridylic-O-tyrosine MOD_RES O-UMP-tyrosine O-Uridinylylation (of Tyrosine) O4'-(phospho-5'-uridine)-L-tyrosine O4'-L-tyrosine 5'-uridine phosphodiester OUMPTyr hydrogen 5'-uridylate tyrosine ester PSI-MOD PhosphoUridine uridine phosphodiester MOD:00261 From DeltaMass: Average Mass: 306. O4'-(phospho-5'-uridine)-L-tyrosine MOD:00261 A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphouridine through a phosphodiester bond to form O4'-(phospho-5'-uridine)-L-tyrosine. DeltaMass:0 PubMed:11467524 PubMed:2885322 RESID:AA0256 Unimod:417#Y DiffAvg: 306.17 DiffFormula: C 9 H 11 N 2 O 8 P 1 DiffMono: 306.025302 Formula: C 18 H 20 N 3 O 10 P 1 MassAvg: 469.34 MassMono: 469.088630 Origin: Y Source: natural TermSpec: none Unimod: Unimod:417 (S)-2-amino-3-[4-(5'-uridine phosphonoxy)phenyl]propanoic acid 5'-uridylic-O-tyrosine MOD_RES O-UMP-tyrosine O-Uridinylylation (of Tyrosine) O4'-(phospho-5'-uridine)-L-tyrosine O4'-L-tyrosine 5'-uridine phosphodiester OUMPTyr hydrogen 5'-uridylate tyrosine ester PhosphoUridine uridine phosphodiester A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and a free L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S,S)-2-(2-aminopentanedio-1-yl)amino-3-(4-hydoxyphenyl)propanoic acid L-glutamyl L-tyrosine N-(L-glutamyl)-L-tyrosine SITE Involved in polymerization PSI-MOD MOD:00262 Cross-link 2. N-(L-glutamyl)-L-tyrosine MOD:00262 A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and a free L-tyrosine. ChEBI:21477 PubMed:6387372 PubMed:8093886 RESID:AA0257 DiffAvg: -17.01 DiffFormula: C 0 H -1 N 0 O -1 DiffMono: -17.002740 Formula: C 14 H 16 N 2 O 5 MassAvg: 292.29 MassMono: 292.105922 Origin: E, Y Source: natural TermSpec: C-term (S,S)-2-(2-aminopentanedio-1-yl)amino-3-(4-hydoxyphenyl)propanoic acid L-glutamyl L-tyrosine N-(L-glutamyl)-L-tyrosine SITE Involved in polymerization A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoviolobilin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4S)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-4,5-dihydro-2,7,13,17-tetramethyl-(21H,22H,24H)-biladiene-bc-1,19-dione BINDING Phycoviolobilin chromophore (covalent; via 1 link) PBV PVB PXB S-phycobiliviolin-L-cysteine S-phycoviolobilin-L-cysteine cryptobiliviolin cryptoviolin cryptoviolobilin PSI-MOD Phycocyanobilin phycocyanobilin MOD:00263 S-phycoviolobilin-L-cysteine MOD:00263 A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoviolobilin. PubMed:2106585 PubMed:3208761 RESID:AA0258 Unimod:387 DiffAvg: 586.69 DiffFormula: C 33 H 38 N 4 O 6 S 0 DiffMono: 586.279135 Formula: C 36 H 43 N 5 O 7 S 1 MassAvg: 689.83 MassMono: 689.288320 Origin: C Source: natural TermSpec: none Unimod: Unimod:387 (4S)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-4,5-dihydro-2,7,13,17-tetramethyl-(21H,22H,24H)-biladiene-bc-1,19-dione BINDING Phycoviolobilin chromophore (covalent; via 1 link) PBV PVB PXB S-phycobiliviolin-L-cysteine S-phycoviolobilin-L-cysteine cryptobiliviolin cryptoviolin cryptoviolobilin Phycocyanobilin phycocyanobilin A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycoerythrobilin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,3R,16R)-3,18-bis-[(R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione 3,18-bis-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-biladiene-ab-8,12-dipropanoic acid BINDING Phycoerythrobilin chromophore (covalent; via 2 links) PEB phycoerythrobilin biscysteine adduct phycoerythrobilin-bis-L-cysteine PSI-MOD MOD:00264 Cross-link 2. phycoerythrobilin-bis-L-cysteine MOD:00264 A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycoerythrobilin. PubMed:3208761 PubMed:3838747 RESID:AA0259 DiffAvg: 586.69 DiffFormula: C 33 H 38 N 4 O 6 S 0 DiffMono: 586.279135 Formula: C 39 H 48 N 6 O 8 S 2 MassAvg: 792.97 MassMono: 792.297505 Origin: C, C Source: natural TermSpec: none (2S,3R,16R)-3,18-bis-[(R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione 3,18-bis-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-biladiene-ab-8,12-dipropanoic acid BINDING Phycoerythrobilin chromophore (covalent; via 2 links) PEB phycoerythrobilin biscysteine adduct phycoerythrobilin-bis-L-cysteine A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycourobilin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-2,7,13,17-tetramethyl-1,19-dioxo-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-8,12-dipropanoic acid 3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-1,19(4H,16H)-dione BINDING Phycourobilin chromophore (covalent; via 2 links) PUB phycourobilin biscysteine adduct phycourobilin-bis-L-cysteine PSI-MOD MOD:00265 Cross-link 2. phycourobilin-bis-L-cysteine MOD:00265 A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycourobilin. PubMed:3208761 PubMed:3838665 PubMed:3838747 PubMed:8876649 RESID:AA0260 DiffAvg: 586.69 DiffFormula: C 33 H 38 N 4 O 6 S 0 DiffMono: 586.279135 Formula: C 39 H 48 N 6 O 8 S 2 MassAvg: 792.97 MassMono: 792.297505 Origin: C, C Source: natural TermSpec: none 3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-2,7,13,17-tetramethyl-1,19-dioxo-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-8,12-dipropanoic acid 3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-1,19(4H,16H)-dione BINDING Phycourobilin chromophore (covalent; via 2 links) PUB phycourobilin biscysteine adduct phycourobilin-bis-L-cysteine A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and one or more free L-glutamic acid molecules to form N-(L-glutamyl)-poly-L-glutamic acid. Origin: Source: TermSpec: PSI-MOD MOD:00266 N-L-glutamyl-poly-L-glutamic acid MOD:00266 A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and one or more free L-glutamic acid molecules to form N-(L-glutamyl)-poly-L-glutamic acid. PubMed:2570347 PubMed:328274 RESID:AA0261 Origin: E Source: natural TermSpec: C-term A protein modification that effectively dioxygenates an L-cysteine residue to L-cysteine sulfinic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0108 (2R)-2-amino-3-sulfinopropanoic acid 2-amino-2-carboxyethanesulfinic acid 2-amino-3-(dioxido-lambda(6)-sulfanyl)propanoic acid [tautomer] 2-amino-3-sulfonylpropanoic acid [tautomer] 3-sulfinoalanine 3-sulphinoalanine CysO2H L-cysteine sulfinic acid MOD_RES Cysteine sulfinic acid (-SO2H) S-cysteinesulfinic acid S-sulfinocysteine cysteine sulphinic acid cysteine-S,S-dioxide [tautomer] sulfinicacid PSI-MOD Dioxidation dihydroxy MOD:00267 "Hyun Ae Woo, et. al., Science 300 (5619), 653-656" L-cysteine sulfinic acid MOD:00267 A protein modification that effectively dioxygenates an L-cysteine residue to L-cysteine sulfinic acid. ChEBI:16345 OMSSA:162 PubMed:12686488 PubMed:9252331 PubMed:9586994 RESID:AA0262 Unimod:425#C DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 S 0 DiffMono: 31.989829 Formula: C 3 H 5 N 1 O 3 S 1 MassAvg: 135.14 MassMono: 134.999014 Origin: C Source: natural TermSpec: none Unimod: Unimod:425 (2R)-2-amino-3-sulfinopropanoic acid 2-amino-2-carboxyethanesulfinic acid 2-amino-3-(dioxido-lambda(6)-sulfanyl)propanoic acid [tautomer] 2-amino-3-sulfonylpropanoic acid [tautomer] 3-sulfinoalanine 3-sulphinoalanine CysO2H L-cysteine sulfinic acid MOD_RES Cysteine sulfinic acid (-SO2H) S-cysteinesulfinic acid S-sulfinocysteine cysteine sulphinic acid cysteine-S,S-dioxide [tautomer] sulfinicacid Dioxidation dihydroxy A protein modification that effectively converts an L-tyrosine residue to L-3',4',5'-trihydroxyphenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0667 (S)-2-amino-3-(3,4,5-trihydroxyphenyl)propanoic acid 3,4,6-Trihydroxy-Phenylalanine (from Tyrosine) (TOPA) 35Hy2Tyr L-3',4',5'-trihydroxyphenylalanine L-3,4,5-TOPA MOD_RES 3',4',5'-trihydroxyphenylalanine PSI-MOD Dioxidation dihydroxy MOD:00268 From DeltaMass: Average Mass: 32 L-3',4',5'-trihydroxyphenylalanine MOD:00268 A protein modification that effectively converts an L-tyrosine residue to L-3',4',5'-trihydroxyphenylalanine. ChEBI:141811 DeltaMass:0 PubMed:12686488 PubMed:12771378 PubMed:8554314 PubMed:9252331 PubMed:9434739 RESID:AA0263 Unimod:425#Y DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 9 H 9 N 1 O 4 MassAvg: 195.17 MassMono: 195.053158 Origin: Y Source: natural TermSpec: none Unimod: Unimod:425 (S)-2-amino-3-(3,4,5-trihydroxyphenyl)propanoic acid 3,4,6-Trihydroxy-Phenylalanine (from Tyrosine) (TOPA) 35Hy2Tyr L-3',4',5'-trihydroxyphenylalanine L-3,4,5-TOPA MOD_RES 3',4',5'-trihydroxyphenylalanine Dioxidation dihydroxy A protein modification that effectively converts an L-serine residue to O-(sn-1-glycerophosphoryl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0230 (2S)-2-amino-3-[(2Xi)-2,3-dihydroxypropyl]phosphonoxypropanoic acid MOD_RES O-(sn-1-glycerophosphoryl)serine O-(sn-1-glycerophosphoryl)-L-serine O3-(sn-1-glycerophosphoryl)-L-serine O3-2,3-dihydroxypropyl hydrogen phosphate-L-serine ester O3-L-serine glyceryl-1-phosphodiester alpha-glycerophosphoryl serine glycerophosphoserine PSI-MOD Glycerophospho glycerophospho MOD:00269 O-(sn-1-glycerophosphoryl)-L-serine MOD:00269 A protein modification that effectively converts an L-serine residue to O-(sn-1-glycerophosphoryl)-L-serine. PubMed:8645220 RESID:AA0264 Unimod:419#S DiffAvg: 154.06 DiffFormula: C 3 H 7 N 0 O 5 P 1 DiffMono: 154.003110 Formula: C 6 H 12 N 1 O 7 P 1 MassAvg: 241.14 MassMono: 241.035138 Origin: S Source: natural TermSpec: none Unimod: Unimod:419 (2S)-2-amino-3-[(2Xi)-2,3-dihydroxypropyl]phosphonoxypropanoic acid MOD_RES O-(sn-1-glycerophosphoryl)serine O-(sn-1-glycerophosphoryl)-L-serine O3-(sn-1-glycerophosphoryl)-L-serine O3-2,3-dihydroxypropyl hydrogen phosphate-L-serine ester O3-L-serine glyceryl-1-phosphodiester alpha-glycerophosphoryl serine glycerophosphoserine Glycerophospho glycerophospho A protein modification that effectively converts a glycine residue to an internal 1-thioglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0004 1-thioglycine 2-amino-1-sulfanylethanone MOD_RES 1-thioglycine S(O)Gly aminoethanethioic O-acid aminoethanethioic acid aminoethanethionic acid aminothioacetic acid PSI-MOD Carboxy->Thiocarboxy thiocarboxylic acid MOD:00270 This modification occurs naturally in two forms. At an interior peptide location it exists as aminoethanethionic acid (or aminoethanethioic O-acid). At the carboxyl-terminal it exists as aminoethanethiolic acid (or aminoethanethioic S-acid). 1-thioglycine (internal) MOD:00270 A protein modification that effectively converts a glycine residue to an internal 1-thioglycine. PubMed:11463785 PubMed:9367957 RESID:AA0265#INT DiffAvg: 16.06 DiffFormula: C 0 H 0 N 0 O -1 S 1 DiffMono: 15.977156 Formula: C 2 H 3 N 1 S 1 MassAvg: 73.11 MassMono: 72.998620 Origin: G Source: natural TermSpec: none 1-thioglycine 2-amino-1-sulfanylethanone MOD_RES 1-thioglycine S(O)Gly aminoethanethioic O-acid aminoethanethioic acid aminoethanethionic acid aminothioacetic acid Carboxy->Thiocarboxy thiocarboxylic acid A protein modification that effectively results from forming an adduct between two cysteine residues, the C-3' of a tyrosine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (10S,11S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-10-(2-hydroxy-5-[(S)-2-amino-2-carboxy]ethylphenyl)-3,8,13,17-tetramethyl-21H,23H-10,11-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate BINDING Heme (covalent; via 3 links) bis(S-cysteinyl)-(tyros-3'-yl)-heme heme P460-bis-L-cysteine-L-tyrosine PSI-MOD MOD:00271 Cross-link 3. heme P460-bis-L-cysteine-L-tyrosine MOD:00271 A protein modification that effectively results from forming an adduct between two cysteine residues, the C-3' of a tyrosine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. PubMed:8325841 PubMed:9095195 RESID:AA0266 DiffAvg: 614.48 DiffFormula: C 34 Fe 1 H 30 N 4 O 4 S 0 DiffMono: 614.161643 Formula: C 49 Fe 1 H 49 N 7 O 8 S 2 MassAvg: 983.94 MassMono: 983.243341 Origin: C, C, Y Source: natural TermSpec: none (10S,11S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-10-(2-hydroxy-5-[(S)-2-amino-2-carboxy]ethylphenyl)-3,8,13,17-tetramethyl-21H,23H-10,11-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate BINDING Heme (covalent; via 3 links) bis(S-cysteinyl)-(tyros-3'-yl)-heme heme P460-bis-L-cysteine-L-tyrosine A protein modification that effectively crosslinks an L-threonine residue and 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0393 (2S,3R)-2-amino-3-(5'-adenosine phosphonoxy)butanoic acid 5'-adenylic-O3-L-threonine ACT_SITE O-AMP-threonine intermediate L-threonine monoanhydride with 5'-adenylic acid MOD_RES O-AMP-threonine O(gamma)-5'-adenylic-L-threonine O-(phospho-5'-adenosine)-L-threonine O3-(phospho-5'-adenosine)-L-threonine O3-L-threonine 5'-adenosine phosphodiester beta-5'-adenylic-L-threonine PSI-MOD AMP binding site Phosphoadenosine MOD:00272 O-(phospho-5'-adenosine)-L-threonine MOD:00272 A protein modification that effectively crosslinks an L-threonine residue and 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-threonine. PubMed:2989287 PubMed:8917428 RESID:AA0267 Unimod:405#T DiffAvg: 329.21 DiffFormula: C 10 H 12 N 5 O 6 P 1 DiffMono: 329.052520 Formula: C 14 H 19 N 6 O 8 P 1 MassAvg: 430.31 MassMono: 430.100198 Origin: T Source: natural TermSpec: none Unimod: Unimod:405 (2S,3R)-2-amino-3-(5'-adenosine phosphonoxy)butanoic acid 5'-adenylic-O3-L-threonine ACT_SITE O-AMP-threonine intermediate L-threonine monoanhydride with 5'-adenylic acid MOD_RES O-AMP-threonine O(gamma)-5'-adenylic-L-threonine O-(phospho-5'-adenosine)-L-threonine O3-(phospho-5'-adenosine)-L-threonine O3-L-threonine 5'-adenosine phosphodiester beta-5'-adenylic-L-threonine AMP binding site Phosphoadenosine A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a four-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4Fe-2S-3O cluster METAL Iron-oxo-sulfur (4Fe-2O-2S) METAL Iron-oxo-sulfur (4Fe-2O-2S); via persulfide group METAL Iron-oxo-sulfur (4Fe-2O-2S); via tele nitrogen hybrid four iron cluster 2 mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-iron-3,4-bis-(S-cysteinyl iron) tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide PSI-MOD prismane iron-sulfur cofactor MOD:00273 Cross-link 7; secondary to RESID:AA0269. tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide MOD:00273 A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a four-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide. PubMed:12764602 RESID:AA0268 DiffAvg: 360.50 DiffFormula: C 0 Fe 4 H -7 N 0 O 3 S 3 DiffMono: 360.585932 Formula: C 28 Fe 4 H 34 N 9 O 14 S 7 MassAvg: 1168.43 MassMono: 1167.766769 Origin: C, C, C, C, E, E, H Source: natural TermSpec: none 4Fe-2S-3O cluster METAL Iron-oxo-sulfur (4Fe-2O-2S) METAL Iron-oxo-sulfur (4Fe-2O-2S); via persulfide group METAL Iron-oxo-sulfur (4Fe-2O-2S); via tele nitrogen hybrid four iron cluster 2 mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-iron-3,4-bis-(S-cysteinyl iron) tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide prismane iron-sulfur cofactor A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a sulfanyl group, forming a disulfanyl group, and converting an L-cysteine residue to L-cysteine persulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0106 (R)-2-amino-3-disulfanylpropanoic acid 2-amino-3-disulfanylpropanoic acid 2-amino-3-hydrodisulfidopropanoic acid 2-amino-3-hydropersulfidopropanoic acid 2-amino-3-persulfhydrylpropanoic acid 3-(thiosulfeno)-alanine 3-disulfanylalanine ACT_SITE Cysteine persulfide intermediate L-cysteine persulfide MOD_RES Cysteine persulfide S-mercaptocysteine S-sulfanylcysteine thiocysteine PSI-MOD Sulfide persulfide MOD:00274 L-cysteine persulfide MOD:00274 A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a sulfanyl group, forming a disulfanyl group, and converting an L-cysteine residue to L-cysteine persulfide. ChEBI:28839 PubMed:15096637 PubMed:4276457 PubMed:8161529 RESID:AA0269 Unimod:421 DiffAvg: 32.06 DiffFormula: C 0 H 0 N 0 O 0 S 1 DiffMono: 31.972071 Formula: C 3 H 5 N 1 O 1 S 2 MassAvg: 135.20 MassMono: 134.981256 Origin: C Source: natural TermSpec: none Unimod: Unimod:421 (R)-2-amino-3-disulfanylpropanoic acid 2-amino-3-disulfanylpropanoic acid 2-amino-3-hydrodisulfidopropanoic acid 2-amino-3-hydropersulfidopropanoic acid 2-amino-3-persulfhydrylpropanoic acid 3-(thiosulfeno)-alanine 3-disulfanylalanine ACT_SITE Cysteine persulfide intermediate L-cysteine persulfide MOD_RES Cysteine persulfide S-mercaptocysteine S-sulfanylcysteine thiocysteine Sulfide persulfide A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3'-(1'-L-histidyl)-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0003 (2S)-2-amino-3-[1-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenyl)-1H-imidazol-4-yl]propanoic acid 3'-(1'-L-histidyl)-L-tyrosine 3'-(N(epsilon)-histidyl)tyrosine 3'-(N1'-histidyl)tyrosine 3'-(tau-histidyl)tyrosine 3'-(tele-histidyl)tyrosine CROSSLNK 1'-histidyl-3'-tyrosine (His-Tyr) PSI-MOD MOD:00275 Cross-link 2. 3'-(1'-L-histidyl)-L-tyrosine MOD:00275 A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3'-(1'-L-histidyl)-L-tyrosine. ChEBI:19837 PubMed:10338009 RESID:AA0270 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 15 H 14 N 4 O 3 MassAvg: 298.30 MassMono: 298.106590 Origin: H, Y Source: natural TermSpec: none (2S)-2-amino-3-[1-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenyl)-1H-imidazol-4-yl]propanoic acid 3'-(1'-L-histidyl)-L-tyrosine 3'-(N(epsilon)-histidyl)tyrosine 3'-(N1'-histidyl)tyrosine 3'-(tau-histidyl)tyrosine 3'-(tele-histidyl)tyrosine CROSSLNK 1'-histidyl-3'-tyrosine (His-Tyr) A protein modification that effectively results from forming an adduct between two cysteine residues, a lysine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (19S,20S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-20-([(S)-5-amino-5-carboxypentyl]amino)-3,8,13,17-tetramethyl-21H,23H-19,20-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate BINDING Heme (covalent; via 3 links) bis(S-cysteinyl)-N6-lysino-heme heme P460-bis-L-cysteine-L-lysine PSI-MOD MOD:00276 Cross-link 3. heme P460-bis-L-cysteine-L-lysine MOD:00276 A protein modification that effectively results from forming an adduct between two cysteine residues, a lysine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. PubMed:12709052 PubMed:9237682 RESID:AA0271 DiffAvg: 614.48 DiffFormula: C 34 Fe 1 H 30 N 4 O 4 S 0 DiffMono: 614.161643 Formula: C 46 Fe 1 H 52 N 8 O 7 S 2 MassAvg: 948.94 MassMono: 948.274976 Origin: C, C, K Source: natural TermSpec: none (19S,20S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-20-([(S)-5-amino-5-carboxypentyl]amino)-3,8,13,17-tetramethyl-21H,23H-19,20-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate BINDING Heme (covalent; via 3 links) bis(S-cysteinyl)-N6-lysino-heme heme P460-bis-L-cysteine-L-lysine A protein modification that effectively converts an L-arginine residue to 5-methyl-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0050 (2S,5S)-2-amino-5-carbamimidamidohexanoic acid 2-amino-5-guanidinohexanoic acid 5-methyl-L-arginine 5-methylated L-arginine C5Me1Arg MOD_RES 5-methylarginine delta-methylarginine PSI-MOD 4-methylarginine Methyl Methylation MOD:00277 5-methyl-L-arginine MOD:00277 A protein modification that effectively converts an L-arginine residue to 5-methyl-L-arginine. PubMed:10660523 PubMed:11875433 PubMed:9367957 RESID:AA0272 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 14 N 4 O 1 MassAvg: 170.22 MassMono: 170.116761 Origin: R Source: natural TermSpec: none (2S,5S)-2-amino-5-carbamimidamidohexanoic acid 2-amino-5-guanidinohexanoic acid 5-methyl-L-arginine 5-methylated L-arginine C5Me1Arg MOD_RES 5-methylarginine delta-methylarginine 4-methylarginine Methyl Methylation A protein modification that effectively converts an L-glutamine residue to 2-methyl-L-glutamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0016 (S)-2-amino-2-methylpentanediamic acid 2-methyl-L-glutamine 2-methylated L-glutamine 2-methylglutamine C2MeGln MOD_RES 2-methylglutamine alpha-methylglutamine PSI-MOD Methyl Methylation MOD:00278 2-methyl-L-glutamine MOD:00278 A protein modification that effectively converts an L-glutamine residue to 2-methyl-L-glutamine. PubMed:10660523 PubMed:11875433 PubMed:9367957 RESID:AA0273 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 6 H 10 N 2 O 2 MassAvg: 142.16 MassMono: 142.074228 Origin: Q Source: natural TermSpec: none (S)-2-amino-2-methylpentanediamic acid 2-methyl-L-glutamine 2-methylated L-glutamine 2-methylglutamine C2MeGln MOD_RES 2-methylglutamine alpha-methylglutamine Methyl Methylation A protein modification that effectively converts an L-cysteine residue to N-pyruvic acid 2-iminyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0224 (R)-2-(1-carboxy-2-sulfanylethanimino)propanoic acid MOD_RES N-pyruvate 2-iminyl-cysteine N-pyruvic acid 2-iminyl-L-cysteine PSI-MOD N-pyruvic acid 2-iminyl PyruvicAcidIminyl MOD:00279 N-pyruvic acid 2-iminyl-L-cysteine MOD:00279 A protein modification that effectively converts an L-cysteine residue to N-pyruvic acid 2-iminyl-L-cysteine. PubMed:1388164 RESID:AA0274 Unimod:422#C DiffAvg: 70.05 DiffFormula: C 3 H 2 N 0 O 2 S 0 DiffMono: 70.005479 Formula: C 6 H 8 N 1 O 3 S 1 MassAvg: 174.19 MassMono: 174.022489 Origin: C Source: natural TermSpec: N-term Unimod: Unimod:422 (R)-2-(1-carboxy-2-sulfanylethanimino)propanoic acid MOD_RES N-pyruvate 2-iminyl-cysteine N-pyruvic acid 2-iminyl-L-cysteine N-pyruvic acid 2-iminyl PyruvicAcidIminyl A protein modification that effectively converts an L-valine residue to N-pyruvic acid 2-iminyl-L-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0225 (S)-2-(1-carboxy-2-methylpropanimino)propanoic acid MOD_RES N-pyruvate 2-iminyl-valine N-pyruvic acid 2-iminyl-L-valine PSI-MOD N-pyruvic acid 2-iminyl PyruvicAcidIminyl MOD:00280 N-pyruvic acid 2-iminyl-L-valine MOD:00280 A protein modification that effectively converts an L-valine residue to N-pyruvic acid 2-iminyl-L-valine. PubMed:2071591 RESID:AA0275 Unimod:422#V DiffAvg: 70.05 DiffFormula: C 3 H 2 N 0 O 2 DiffMono: 70.005479 Formula: C 8 H 12 N 1 O 3 MassAvg: 170.19 MassMono: 170.081718 Origin: V Source: natural TermSpec: N-term Unimod: Unimod:422 (S)-2-(1-carboxy-2-methylpropanimino)propanoic acid MOD_RES N-pyruvate 2-iminyl-valine N-pyruvic acid 2-iminyl-L-valine N-pyruvic acid 2-iminyl PyruvicAcidIminyl A protein modification that effectively results from forming an adduct between the pros nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-[1-(N3'-histidyl)ethyl]protoporphyrin IX 3'-heme-L-histidine BINDING Heme (covalent; via pros nitrogen) N(delta)-histidyl heme N(pi)-histidyl heme N3'-histidyl heme [7-ethenyl-12-((S)-1-[((R)-2-amino-2-carboxyethyl)-3H-imidazol-3-yl]ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate pros-histidyl heme PSI-MOD MOD:00281 3'-heme-L-histidine MOD:00281 A protein modification that effectively results from forming an adduct between the pros nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. PubMed:12119398 PubMed:12429096 PubMed:12486054 PubMed:9712585 RESID:AA0276 DiffAvg: 616.50 DiffFormula: C 34 Fe 1 H 32 N 4 O 4 DiffMono: 616.177293 Formula: C 40 Fe 1 H 39 N 7 O 5 MassAvg: 753.64 MassMono: 753.236205 Origin: H Source: natural TermSpec: none 2-[1-(N3'-histidyl)ethyl]protoporphyrin IX 3'-heme-L-histidine BINDING Heme (covalent; via pros nitrogen) N(delta)-histidyl heme N(pi)-histidyl heme N3'-histidyl heme [7-ethenyl-12-((S)-1-[((R)-2-amino-2-carboxyethyl)-3H-imidazol-3-yl]ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate pros-histidyl heme A protein modification that effectively converts an L-cysteine residue to S-selenyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0282 (R)-2-amino-3-(selanylsulfanyl)propanoic acid 2-amino-3-hydroselenosulfidopropanoic acid 2-amino-3-hydroselenylsulfidopropanoic acid 2-amino-3-hydroselenylthiopropanoic acid ACT_SITE S-selanylcysteine intermediate MOD_RES S-selenylcysteine S-selanyl-L-cysteine S-selanylcysteine S-selenylcysteine PSI-MOD Delta:Se(1) cysteine perselenide selenyl MOD:00282 S-selenyl-L-cysteine MOD:00282 A protein modification that effectively converts an L-cysteine residue to S-selenyl-L-cysteine. PubMed:10430865 PubMed:10966817 PubMed:11827487 PubMed:12716131 PubMed:14594807 RESID:AA0277 Unimod:423#C DiffAvg: 78.97 DiffFormula: C 0 H 0 N 0 O 0 S 0 Se 1 DiffMono: 79.916521 Formula: C 3 H 5 N 1 O 1 S 1 Se 1 MassAvg: 182.11 MassMono: 182.925706 Origin: C Source: hypothetical TermSpec: none Unimod: Unimod:423 (R)-2-amino-3-(selanylsulfanyl)propanoic acid 2-amino-3-hydroselenosulfidopropanoic acid 2-amino-3-hydroselenylsulfidopropanoic acid 2-amino-3-hydroselenylthiopropanoic acid ACT_SITE S-selanylcysteine intermediate MOD_RES S-selenylcysteine S-selanyl-L-cysteine S-selanylcysteine S-selenylcysteine Delta:Se(1) cysteine perselenide selenyl A protein modification that effectively converts an L-lysine residue to an N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine. Origin: Source: TermSpec: uniprot.ptm:PTM-0198 (alpha)- ([([(5S)-5-amino-5-carboxypentyl]amino)propyl][(methyl)amino])-(omega)-methyl poly[propane-1,3-diyl(methylimino)] MOD_RES N6-poly(methylaminopropyl)lysine N6-[3-([(omega)-(dimethyl)aminopropyl-poly(3-[methylamino]propyl)]amino)propyl]lysine N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine lysine derivative Lys(x) silaffin polycationic lysine derivative PSI-MOD MOD:00283 N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine MOD:00283 A protein modification that effectively converts an L-lysine residue to an N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine. PubMed:10550045 PubMed:11349130 RESID:AA0278 Origin: K Source: natural TermSpec: none (alpha)- ([([(5S)-5-amino-5-carboxypentyl]amino)propyl][(methyl)amino])-(omega)-methyl poly[propane-1,3-diyl(methylimino)] MOD_RES N6-poly(methylaminopropyl)lysine N6-[3-([(omega)-(dimethyl)aminopropyl-poly(3-[methylamino]propyl)]amino)propyl]lysine N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine lysine derivative Lys(x) silaffin polycationic lysine derivative A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester BINDING Heme (covalent; via 2 links) [13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-7,12-diethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate dihydroxyheme-L-aspartate ester-L-glutamate ester peroxidase heme cofactor PSI-MOD MOD:00284 Cross-link 2. dihydroxyheme-L-aspartate ester-L-glutamate ester MOD:00284 A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. PubMed:10447690 RESID:AA0279 DiffAvg: 612.47 DiffFormula: C 34 Fe 1 H 28 N 4 O 4 DiffMono: 612.145993 Formula: C 43 Fe 1 H 40 N 6 O 10 MassAvg: 856.67 MassMono: 856.215529 Origin: D, E Source: hypothetical TermSpec: none 1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester BINDING Heme (covalent; via 2 links) [13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-7,12-diethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate dihydroxyheme-L-aspartate ester-L-glutamate ester peroxidase heme cofactor A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, a methionine residue (forming a sulfonium ether), and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester 2-methionine sulfonium BINDING Heme (covalent; via 3 links) [13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-12-[(S)-(3-amino-3-carboxy)propylsulfoniumethyl]-7-ethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium myeloperoxidase heme cofactor PSI-MOD MOD:00285 Cross-link 3. dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium MOD:00285 A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, a methionine residue (forming a sulfonium ether), and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. PubMed:10447690 PubMed:10480885 PubMed:1320128 PubMed:7840679 RESID:AA0280 DiffAvg: 613.47 DiffFormula: C 34 Fe 1 H 29 N 4 O 4 S 0 DiffMono: 613.153269 FormalCharge: 1+ Formula: C 48 Fe 1 H 50 N 7 O 11 S 1 MassAvg: 988.87 MassMono: 988.263290 Origin: D, E, M Source: natural TermSpec: none 1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester 2-methionine sulfonium BINDING Heme (covalent; via 3 links) [13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-12-[(S)-(3-amino-3-carboxy)propylsulfoniumethyl]-7-ethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium myeloperoxidase heme cofactor A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide) bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-cystein-S-yl-molybdenum PSI-MOD MolybdopterinGD molybdenum bis(molybdopterin guanine dinucleotide) MOD:00286 L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide) MOD:00286 A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide). RESID:AA0281 Unimod:424#C DiffAvg: 1572.02 DiffFormula: C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 DiffMono: 1572.985775 Formula: C 43 H 52 Mo 1 N 21 O 27 P 4 S 5 MassAvg: 1675.15 MassMono: 1675.994960 Origin: C Source: hypothetical TermSpec: none Unimod: Unimod:424 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide) bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-cystein-S-yl-molybdenum MolybdopterinGD molybdenum bis(molybdopterin guanine dinucleotide) A protein modification that effectively converts an L-proline residue to a (2S,3R,4S)-3,4-dihydroxyproline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0306 (2S,3R,4S)-3,4-dihydroxyproline (2S,3R,4S)-3,4-dihydroxypyrrolidine-2-carboxylic acid 2,3-trans-3,4-cis-3,4-dihydroxy-L-proline 2-alpha-3-beta-4-beta-3,4-dihydroxyproline 3,4-Dihydroxylation (of Proline) 3,4-dihydroxylated L-proline 34Hy2Pro MOD_RES (3R,4S)-3,4-dihydroxyproline trans-2,3-cis-3,4-dihydroxy-L-proline PSI-MOD Dioxidation dihydroxy MOD:00287 From DeltaMass: Average Mass: 32. (2S,3R,4S)-3,4-dihydroxyproline MOD:00287 A protein modification that effectively converts an L-proline residue to a (2S,3R,4S)-3,4-dihydroxyproline. ChEBI:141803 DeltaMass:0 PubMed:12686488 RESID:AA0282 Unimod:425#P DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: P Source: natural TermSpec: none Unimod: Unimod:425 (2S,3R,4S)-3,4-dihydroxyproline (2S,3R,4S)-3,4-dihydroxypyrrolidine-2-carboxylic acid 2,3-trans-3,4-cis-3,4-dihydroxy-L-proline 2-alpha-3-beta-4-beta-3,4-dihydroxyproline 3,4-Dihydroxylation (of Proline) 3,4-dihydroxylated L-proline 34Hy2Pro MOD_RES (3R,4S)-3,4-dihydroxyproline trans-2,3-cis-3,4-dihydroxy-L-proline Dioxidation dihydroxy A protein modification that effectively doubly cross-links an L-glutamic acid residue and an L-tyrosine residue with a carbon-carbon bond and a carbon-nitrogen bond to form pyrroloquinoline quinone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0263 2,4,6-tricarboxylic-pyrrolo[2,3-5,6]quinoline 8,9-quinone 2,7,9-tricarboxy-1H-pyrrolo(2,3-f)quinoline-4,5-dione 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-5,6]quinoline-2,7,9-tricarboxylic acid CROSSLNK Pyrroloquinoline quinone (Glu-Tyr) coenzyme PQQ methoxatin pyrroloquinoline quinone PSI-MOD MOD:00288 Cross-link 2. pyrroloquinoline quinone MOD:00288 A protein modification that effectively doubly cross-links an L-glutamic acid residue and an L-tyrosine residue with a carbon-carbon bond and a carbon-nitrogen bond to form pyrroloquinoline quinone. ChEBI:18315 PubMed:1310505 PubMed:7665488 RESID:AA0283 DiffAvg: 37.92 DiffFormula: C 0 H -10 N 0 O 3 DiffMono: 37.906494 Formula: C 14 H 6 N 2 O 8 MassAvg: 330.21 MassMono: 330.012415 Origin: E, Y Source: natural TermSpec: none 2,4,6-tricarboxylic-pyrrolo[2,3-5,6]quinoline 8,9-quinone 2,7,9-tricarboxy-1H-pyrrolo(2,3-f)quinoline-4,5-dione 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-5,6]quinoline-2,7,9-tricarboxylic acid CROSSLNK Pyrroloquinoline quinone (Glu-Tyr) coenzyme PQQ methoxatin pyrroloquinoline quinone A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (4Fe-4S) METAL Iron-sulfur (4Fe-4S); via tele nitrogen tetra-mu3-sulfidotris(S-cysteinyliron)(N1'-histidinoiron) tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide PSI-MOD MOD:00289 Cross-link 4. tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide MOD:00289 A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide. PubMed:9836629 RESID:AA0284 DiffAvg: 347.59 DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono: 347.597831 FormalCharge: 2- Formula: C 15 Fe 4 H 18 N 6 O 4 S 7 MassAvg: 794.15 MassMono: 793.684297 Origin: C, C, C, H Source: natural TermSpec: none METAL Iron-sulfur (4Fe-4S) METAL Iron-sulfur (4Fe-4S); via tele nitrogen tetra-mu3-sulfidotris(S-cysteinyliron)(N1'-histidinoiron) tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (4Fe-4S) METAL Iron-sulfur (4Fe-4S); via pros nitrogen tetra-mu3-sulfidotris(S-cysteinyliron)(N3'-histidinoiron) tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide PSI-MOD MOD:00290 Cross-link 4. tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide MOD:00290 A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide. PubMed:7854413 RESID:AA0285 DiffAvg: 347.59 DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono: 347.597831 FormalCharge: 2- Formula: C 15 Fe 4 H 18 N 6 O 4 S 7 MassAvg: 794.15 MassMono: 793.684297 Origin: C, C, C, H Source: natural TermSpec: none METAL Iron-sulfur (4Fe-4S) METAL Iron-sulfur (4Fe-4S); via pros nitrogen tetra-mu3-sulfidotris(S-cysteinyliron)(N3'-histidinoiron) tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-aspartato tetrairon tetrasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (4Fe-4S) tetra-mu3-sulfidotris(S-cysteinyliron)(O4-aspartatoiron) tris-L-cysteinyl L-aspartato tetrairon tetrasulfide PSI-MOD MOD:00291 Cross-link 4. tris-L-cysteinyl L-aspartato tetrairon tetrasulfide MOD:00291 A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-aspartato tetrairon tetrasulfide. PubMed:7819255 PubMed:9283079 RESID:AA0286 DiffAvg: 347.59 DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono: 347.597831 FormalCharge: 2- Formula: C 13 Fe 4 H 16 N 4 O 6 S 7 MassAvg: 772.09 MassMono: 771.652328 Origin: C, C, C, D Source: natural TermSpec: none METAL Iron-sulfur (4Fe-4S) tetra-mu3-sulfidotris(S-cysteinyliron)(O4-aspartatoiron) tris-L-cysteinyl L-aspartato tetrairon tetrasulfide A protein modification that effectively converts an L-lysine residue to N6-pyruvic acid 2-iminyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-6-([1-carboxyethylidene]amino)hexanoic acid ACT_SITE Schiff-base intermediate with substrate N6-pyruvic acid 2-iminyl-L-lysine PSI-MOD N-pyruvic acid 2-iminyl PyruvicAcidIminyl MOD:00292 N6-pyruvic acid 2-iminyl-L-lysine MOD:00292 A protein modification that effectively converts an L-lysine residue to N6-pyruvic acid 2-iminyl-L-lysine. PubMed:1463470 PubMed:7853400 PubMed:9047371 RESID:AA0287 Unimod:422#K DiffAvg: 70.05 DiffFormula: C 3 H 2 N 0 O 2 DiffMono: 70.005479 Formula: C 9 H 14 N 2 O 3 MassAvg: 198.22 MassMono: 198.100442 Origin: K Source: natural TermSpec: none Unimod: Unimod:422 (2S)-2-amino-6-([1-carboxyethylidene]amino)hexanoic acid ACT_SITE Schiff-base intermediate with substrate N6-pyruvic acid 2-iminyl-L-lysine N-pyruvic acid 2-iminyl PyruvicAcidIminyl A protein modification that effectively converts three L-cysteine residues, an L-serine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-serinyl tetrairon tetrasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: tetra-mu3-sulfidotris(S-cysteinyliron)(O3-serinyliron) tris-L-cysteinyl L-serinyl tetrairon tetrasulfide PSI-MOD MOD:00293 Cross-link 4. tris-L-cysteinyl L-serinyl tetrairon tetrasulfide MOD:00293 A protein modification that effectively converts three L-cysteine residues, an L-serine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-serinyl tetrairon tetrasulfide. RESID:AA0288 DiffAvg: 347.59 DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono: 347.597831 FormalCharge: 2- Formula: C 12 Fe 4 H 16 N 4 O 5 S 7 MassAvg: 744.08 MassMono: 743.657414 Origin: C, C, C, S Source: hypothetical TermSpec: none tetra-mu3-sulfidotris(S-cysteinyliron)(O3-serinyliron) tris-L-cysteinyl L-serinyl tetrairon tetrasulfide A protein modification that effectively converts two L-cysteine residues, an L-histidine residues, an L-serine residue and a four-iron four-sulfur cluster to bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (4Fe-4S) METAL Iron-sulfur (4Fe-4S); via pros nitrogen bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide tetra-mu3-sulfidobis(S-cysteinyliron)(N3'-histidinoiron)(O3-serinyliron) PSI-MOD MOD:00294 Cross-link 4. bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide MOD:00294 A protein modification that effectively converts two L-cysteine residues, an L-histidine residues, an L-serine residue and a four-iron four-sulfur cluster to bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide. RESID:AA0289 DiffAvg: 347.59 DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono: 347.597831 FormalCharge: 2- Formula: C 15 Fe 4 H 18 N 6 O 5 S 6 MassAvg: 778.09 MassMono: 777.707141 Origin: C, C, H, S Source: hypothetical TermSpec: none METAL Iron-sulfur (4Fe-4S) METAL Iron-sulfur (4Fe-4S); via pros nitrogen bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide tetra-mu3-sulfidobis(S-cysteinyliron)(N3'-histidinoiron)(O3-serinyliron) A protein modification that effectively converts an L-serine residue to O-octanoyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0239 (2S)-2-amino-3-(octanoyloxy)propanoic acid L-serine octanoate ester LIPID O-octanoyl serine O-octanoyl-L-serine O-octanoylated L-serine O3-octanoyl-L-serine OOctSer PSI-MOD Octanoyl octanoyl MOD:00295 O-octanoyl-L-serine MOD:00295 A protein modification that effectively converts an L-serine residue to O-octanoyl-L-serine. PubMed:10604470 PubMed:12716131 RESID:AA0290 Unimod:426#S DiffAvg: 126.20 DiffFormula: C 8 H 14 N 0 O 1 DiffMono: 126.104465 Formula: C 11 H 19 N 1 O 3 MassAvg: 213.28 MassMono: 213.136493 Origin: S Source: natural TermSpec: none Unimod: Unimod:426 (2S)-2-amino-3-(octanoyloxy)propanoic acid L-serine octanoate ester LIPID O-octanoyl serine O-octanoyl-L-serine O-octanoylated L-serine O3-octanoyl-L-serine OOctSer Octanoyl octanoyl A protein modification that effectively converts an L-serine residue to O-D-glucuronosyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0577 (2S)-2-amino-3-(beta-D-glucopyranuronosyl)propanoic acid CARBOHYD O-linked (GlcA) serine O-D-glucuronosyl-L-serine O3-D-glucuronosyl-L-serine PSI-MOD Glucuronyl N-glucuronylation MOD:00296 O-D-glucuronosyl-L-serine MOD:00296 A protein modification that effectively converts an L-serine residue to O-D-glucuronosyl-L-serine. PubMed:10858503 PubMed:12716131 PubMed:7398618 RESID:AA0291 Unimod:54#S DiffAvg: 176.12 DiffFormula: C 6 H 8 N 0 O 6 DiffMono: 176.032088 Formula: C 9 H 13 N 1 O 8 MassAvg: 263.20 MassMono: 263.064116 Origin: S Source: natural TermSpec: none Unimod: Unimod:54 (2S)-2-amino-3-(beta-D-glucopyranuronosyl)propanoic acid CARBOHYD O-linked (GlcA) serine O-D-glucuronosyl-L-serine O3-D-glucuronosyl-L-serine Glucuronyl N-glucuronylation A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Ni-3Fe-2S-3O cluster carbon monoxide dehydrogenase nickel-iron cofactor hybrid nickel-triiron cluster mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-nickel-3,4-bis-(S-cysteinyl iron) tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide PSI-MOD MOD:00297 Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide MOD:00297 A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. RESID:AA0292 DiffAvg: 363.35 DiffFormula: C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3 DiffMono: 362.586337 Formula: C 28 Fe 3 H 34 N 9 Ni 1 O 14 S 7 MassAvg: 1171.28 MassMono: 1169.767174 Origin: C, C, C, C, E, E, H Source: artifact TermSpec: none Ni-3Fe-2S-3O cluster carbon monoxide dehydrogenase nickel-iron cofactor hybrid nickel-triiron cluster mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-nickel-3,4-bis-(S-cysteinyl iron) tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide A protein modification that effectively converts four L-cysteine residues, an L-glutamic acid residue, an L-histidine residue, an L-serine residue and a one-nickel three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Ni-3Fe-2S-3O cluster carbon monoxide dehydrogenase nickel-iron cofactor hybrid nickel-triiron cluster mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O3-serinyl 2-nickel-3,4-bis-(S-cysteinyl iron) tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide PSI-MOD MOD:00298 Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide MOD:00298 A protein modification that effectively converts four L-cysteine residues, an L-glutamic acid residue, an L-histidine residue, an L-serine residue and a one-nickel three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. PubMed:2550436 RESID:AA0293 DiffAvg: 363.35 DiffFormula: C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3 DiffMono: 362.586337 Formula: C 26 Fe 3 H 32 N 9 Ni 1 O 13 S 7 MassAvg: 1129.24 MassMono: 1127.756609 Origin: C, C, C, C, E, H, S Source: artifact TermSpec: none Ni-3Fe-2S-3O cluster carbon monoxide dehydrogenase nickel-iron cofactor hybrid nickel-triiron cluster mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O3-serinyl 2-nickel-3,4-bis-(S-cysteinyl iron) tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide A protein modification that effectively crosslinks an L-asparagine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0153 (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) N(epsilon)-(beta-aspartyl)lysine N-(beta-Aspartyl)-Lysine (Crosslink) N6-(L-isoaspartyl)-L-lysine XLNK-4Asp-N6Lys(Asn) beta-(N6-lysyl)aspartyl acid isoaspartyl N6-lysine PSI-MOD MOD:00299 Cross-link 2. N6-(L-isoaspartyl)-L-lysine (Asn) MOD:00299 A protein modification that effectively crosslinks an L-asparagine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of ammonia. ChEBI:21862 DeltaMass:0 PubMed:11000116 PubMed:6503713 RESID:AA0294 DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 10 H 15 N 3 O 3 MassAvg: 225.25 MassMono: 225.111341 Origin: K, N Source: natural TermSpec: none (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) N(epsilon)-(beta-aspartyl)lysine N-(beta-Aspartyl)-Lysine (Crosslink) N6-(L-isoaspartyl)-L-lysine XLNK-4Asp-N6Lys(Asn) beta-(N6-lysyl)aspartyl acid isoaspartyl N6-lysine A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose). Origin: Source: TermSpec: Unimod: (S)-2-amino-5-poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl]oxy-5-oxopentanoic acid L-glutamyl-5-poly(ADP-ribose) L-isoglutamyl-poly(ADP-ribose) MOD_RES PolyADP-ribosyl glutamic acid O-ADP-ribosylation (on Glutamate or C terminus) PSI-MOD ADP Ribose addition ADP-Ribosyl MOD:00300 L-glutamyl-5-poly(ADP-ribose) MOD:00300 A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose). DeltaMass:0 PubMed:11246023 PubMed:15842200 PubMed:8533153 RESID:AA0295 Unimod:213#E Origin: E Source: natural TermSpec: none Unimod: Unimod:213 (S)-2-amino-5-poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl]oxy-5-oxopentanoic acid L-glutamyl-5-poly(ADP-ribose) L-isoglutamyl-poly(ADP-ribose) MOD_RES PolyADP-ribosyl glutamic acid O-ADP-ribosylation (on Glutamate or C terminus) ADP Ribose addition ADP-Ribosyl A protein modification that effectively converts an L-serine residue to O-(N-acetylglucosamine-1-phosphoryl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0586 (2S)-2-amino-3-[([(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxy][hydroxy]phosphoryl)oxy]propanoic acid CARBOHYD O-linked (GalNAcP) serine O-(N-acetylglucosamine-1-phosphoryl)-L-serine O-GlcNAc-1-phosphorylation (of Serine) O-beta(N-acetyl-glucosamine-alpha1-phosphate)serine O3-(N-acetylglucosamine-1-phosphoryl)-L-serine O3-L-serine 2-(acetylamino)-2-deoxy-D-glucopyranose 1-phosphodiester PSI-MOD N-acetylglucosamine-1-phosphoryl PhosphoHexNAc MOD:00301 O-(N-acetylglucosamine-1-phosphoryl)-L-serine MOD:00301 A protein modification that effectively converts an L-serine residue to O-(N-acetylglucosamine-1-phosphoryl)-L-serine. DeltaMass:0 PubMed:6438439 PubMed:6993483 PubMed:8631906 RESID:AA0296 Unimod:428 DiffAvg: 283.17 DiffFormula: C 8 H 14 N 1 O 8 P 1 DiffMono: 283.045703 Formula: C 11 H 19 N 2 O 10 P 1 MassAvg: 370.25 MassMono: 370.077731 Origin: S Source: natural TermSpec: none Unimod: Unimod:428 (2S)-2-amino-3-[([(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxy][hydroxy]phosphoryl)oxy]propanoic acid CARBOHYD O-linked (GalNAcP) serine O-(N-acetylglucosamine-1-phosphoryl)-L-serine O-GlcNAc-1-phosphorylation (of Serine) O-beta(N-acetyl-glucosamine-alpha1-phosphate)serine O3-(N-acetylglucosamine-1-phosphoryl)-L-serine O3-L-serine 2-(acetylamino)-2-deoxy-D-glucopyranose 1-phosphodiester N-acetylglucosamine-1-phosphoryl PhosphoHexNAc A protein modification that effectively converts an L-serine residue to O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0594 CARBOHYD O-linked (Man1P) serine O-(D-mannose-1-phosphoryl)-L-serine O-(alpha-D-mannosyl-1-phosphoryl)-L-serine O-[alpha-D-mannopyranosyloxy(hydroxy)phosphoryl]-L-serine O3-(D-mannose-1-phosphoryl)-L-serine O3-L-serine alpha-D-mannopyranose 1-phosphodiester PSI-MOD PhosphoHex phosphoglycosyl-D-mannose-1-phosphoryl MOD:00302 O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine MOD:00302 A protein modification that effectively converts an L-serine residue to O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. PubMed:10037765 PubMed:15649890 RESID:AA0297 Unimod:429 DiffAvg: 242.12 DiffFormula: C 6 H 11 N 0 O 8 P 1 DiffMono: 242.019154 Formula: C 9 H 16 N 1 O 10 P 1 MassAvg: 329.20 MassMono: 329.051182 Origin: S Source: natural TermSpec: none Unimod: Unimod:429 CARBOHYD O-linked (Man1P) serine O-(D-mannose-1-phosphoryl)-L-serine O-(alpha-D-mannosyl-1-phosphoryl)-L-serine O-[alpha-D-mannopyranosyloxy(hydroxy)phosphoryl]-L-serine O3-(D-mannose-1-phosphoryl)-L-serine O3-L-serine alpha-D-mannopyranose 1-phosphodiester PhosphoHex phosphoglycosyl-D-mannose-1-phosphoryl A protein modification that effectively converts seven L-histidinine residues and a four-copper one-sulfur one-hydroxide cluster to heptakis-L-histidino tetracopper mu4-sulfide hydroxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: heptakis-L-histidino tetracopper mu4-sulfide hydroxide mu4-sulfido bis(bis-N1'-histidino copper)(N1'-histidino-N3'-histidino copper)(N3'-histidino hydroxide copper) nitrous oxide reductase nosZ CuZ cluster pentakis-L-N1'-histidino-bis-L-N3'-histidino tetracopper sulfide hydroxide PSI-MOD MOD:00303 Cross-link 7. heptakis-L-histidino tetracopper mu4-sulfide hydroxide MOD:00303 A protein modification that effectively converts seven L-histidinine residues and a four-copper one-sulfur one-hydroxide cluster to heptakis-L-histidino tetracopper mu4-sulfide hydroxide. PubMed:11024061 PubMed:11041839 RESID:AA0298 DiffAvg: 296.19 DiffFormula: C 0 Cu 4 H -6 N 0 O 1 S 1 DiffMono: 293.638425 Formula: C 42 Cu 4 H 43 N 21 O 8 S 1 MassAvg: 1256.19 MassMono: 1253.050808 Origin: H, H, H, H, H, H, H Source: natural TermSpec: none heptakis-L-histidino tetracopper mu4-sulfide hydroxide mu4-sulfido bis(bis-N1'-histidino copper)(N1'-histidino-N3'-histidino copper)(N3'-histidino hydroxide copper) nitrous oxide reductase nosZ CuZ cluster pentakis-L-N1'-histidino-bis-L-N3'-histidino tetracopper sulfide hydroxide A protein modification that effectively converts an L-leucine residue to L-leucine methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0167 2-amino-4-methylpentanoic methyl ester L-leucine methyl ester MOD_RES Leucine methyl ester OMeLeu alpha-aminoisocaproic methyl ester methyl (2S)-2-amino-4-methylpentanoate methyl L-leucinate methyl esterified L-leucine PSI-MOD Methyl Methylation MOD:00304 incidental to RESID:AA0039 L-leucine methyl ester MOD:00304 A protein modification that effectively converts an L-leucine residue to L-leucine methyl ester. PubMed:10191253 PubMed:11875433 PubMed:8206937 RESID:AA0299 Unimod:34#C-term DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 14 N 1 O 2 MassAvg: 144.19 MassMono: 144.102454 Origin: L Source: natural TermSpec: C-term Unimod: Unimod:34 2-amino-4-methylpentanoic methyl ester L-leucine methyl ester MOD_RES Leucine methyl ester OMeLeu alpha-aminoisocaproic methyl ester methyl (2S)-2-amino-4-methylpentanoate methyl L-leucinate methyl esterified L-leucine Methyl Methylation A protein modification that effectively converts six L-cysteine residues, an L-serine residue and a eight-iron seven-sulfur cluster to hexakis-L-cysteinyl L-serinyl octairon heptasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Cys6Ser-[8Fe7S] METAL Iron-sulfur (8Fe-7S) hexakis-L-cysteinyl L-serinyl octairon heptasulfide nitrogenase P-cluster PSI-MOD MOD:00305 Cross-link 7; incidental to RESID:AA0141. hexakis-L-cysteinyl L-serinyl octairon heptasulfide MOD:00305 A protein modification that effectively converts six L-cysteine residues, an L-serine residue and a eight-iron seven-sulfur cluster to hexakis-L-cysteinyl L-serinyl octairon heptasulfide. PubMed:10525412 PubMed:12215645 PubMed:9063865 RESID:AA0300 DiffAvg: 663.12 DiffFormula: C 0 Fe 8 H -8 N 0 O 0 S 7 DiffMono: 663.223042 FormalCharge: 3- Formula: C 21 Fe 8 H 27 N 7 O 8 S 13 MassAvg: 1369.03 MassMono: 1368.310179 Origin: C, C, C, C, C, C, S Source: natural TermSpec: none Cys6Ser-[8Fe7S] METAL Iron-sulfur (8Fe-7S) hexakis-L-cysteinyl L-serinyl octairon heptasulfide nitrogenase P-cluster Natural or modified residues with a mass of 113.084064 Da. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: L-isoleucine or L-leucine Xle PSI-MOD MOD:00306 residues isobaric at 113.084064 Da MOD:00306 Natural or modified residues with a mass of 113.084064 Da. PubMed:10523135 RESID:AA0301 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 6 H 11 N 1 O 1 MassAvg: 113.16 MassMono: 113.084064 Origin: X Source: none TermSpec: none L-isoleucine or L-leucine Xle A protein modification that effectively cyclizes an L-asparagine residue to form a carboxyl-terminal L-aspartimide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (3S)-3-amino-2,5-pyrrolidinedione 2-amino-butanimide ASI L-2-aminosuccinimide L-asparaginimide L-aspartimide Succinimide formation from asparagine alpha-aminosuccinimide PSI-MOD Dehydrated Dehydration L-3-aminosuccinimide MOD:00307 From DeltaMass: Average Mass: -17 Average Mass Change:-17 References:Clarke, S., Lability of Aspargine and Aspartic Acid Residues in Protein and Peptides, in: Stability of Protein Pharmaceuticals : Chemical and Physical Paths of Protein Degradation, Part A (T.J. Ahern and M.C. Manning, eds.), 1992,Plenum Press, New York, pp.1-29Xie, M.; Vander Velde, D.; Morton, M.; Borchardt, R.T.; Schowen,R.L.: pH-Induced Change in the Rate-Determining Step for the Hydrolysis of the Asp/Asn-Derived Cyclic-Imide Intermediate in Protein Degradation. (1996) J. Am. Chem. Soc. 118: 8955-8956. L-aspartimide MOD:00307 A protein modification that effectively cyclizes an L-asparagine residue to form a carboxyl-terminal L-aspartimide. DeltaMass:18 PubMed:12771378 PubMed:2378679 PubMed:7662664 PubMed:7988548 PubMed:9309583 RESID:AA0302 Unimod:23#N DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 4 H 5 N 2 O 2 MassAvg: 113.10 MassMono: 113.035102 Origin: N Source: natural TermSpec: C-term Unimod: Unimod:23 (3S)-3-amino-2,5-pyrrolidinedione 2-amino-butanimide ASI L-2-aminosuccinimide L-asparaginimide L-aspartimide Succinimide formation from asparagine alpha-aminosuccinimide Dehydrated Dehydration L-3-aminosuccinimide A protein modification that effectively cyclizes an L-glutamine residue to form a carboxyl-terminal L-glutamimide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (3S)-3-aminopiperidine-2,6-dione 2-aminopentanimide 3-amino-2,6-piperidinedione L-glutamimide alpha-aminoglutarimide PSI-MOD Dehydrated Dehydration MOD:00308 L-glutamimide MOD:00308 A protein modification that effectively cyclizes an L-glutamine residue to form a carboxyl-terminal L-glutamimide. PubMed:12771378 PubMed:14593103 RESID:AA0303 Unimod:23#Q DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 5 H 7 N 2 O 2 MassAvg: 127.12 MassMono: 127.050752 Origin: Q Source: hypothetical TermSpec: C-term Unimod: Unimod:23 (3S)-3-aminopiperidine-2,6-dione 2-aminopentanimide 3-amino-2,6-piperidinedione L-glutamimide alpha-aminoglutarimide Dehydrated Dehydration A protein modification that effectively converts an L-aspartic acid residue to L-beta-carboxyaspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-aminoethane-1,1,2-tricarboxylic acid 2-amino-3-carboxybutanedioic acid 3-carboxy-L-aspartic acid 3-carboxyaspartic acid 3CbxAsp beta-carboxyaspartic acid gammacarboxyld PSI-MOD Carboxy Carboxylation MOD:00309 References to this modification as a gamma-carboxylation are in error [JSG]. L-beta-carboxyaspartic acid MOD:00309 A protein modification that effectively converts an L-aspartic acid residue to L-beta-carboxyaspartic acid. OMSSA:47 PubMed:6390094 PubMed:7138832 PubMed:7457858 PubMed:8135347 RESID:AA0304 Unimod:299#D DiffAvg: 44.01 DiffFormula: C 1 H 0 N 0 O 2 DiffMono: 43.989829 Formula: C 5 H 5 N 1 O 5 MassAvg: 159.10 MassMono: 159.016772 Origin: D Source: hypothetical TermSpec: none Unimod: Unimod:299 (2S)-2-aminoethane-1,1,2-tricarboxylic acid 2-amino-3-carboxybutanedioic acid 3-carboxy-L-aspartic acid 3-carboxyaspartic acid 3CbxAsp beta-carboxyaspartic acid gammacarboxyld Carboxy Carboxy Carboxylation A protein modification that effectively converts an L-arginine residue to N5-methyl-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0185 (2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic acid MOD_RES N5-methylarginine N5-carbamimidoyl-N5-methyl-L-ornithine N5-methyl-L-arginine N5-methylated L-arginine N5Me1Arg delta-N-methylarginine PSI-MOD Methyl Methylation MOD:00310 N5-methyl-L-arginine MOD:00310 A protein modification that effectively converts an L-arginine residue to N5-methyl-L-arginine. PubMed:11875433 PubMed:9792625 PubMed:9873020 RESID:AA0305 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 14 N 4 O 1 MassAvg: 170.22 MassMono: 170.116761 Origin: R Source: hypothetical TermSpec: none (2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic acid MOD_RES N5-methylarginine N5-carbamimidoyl-N5-methyl-L-ornithine N5-methyl-L-arginine N5-methylated L-arginine N5Me1Arg delta-N-methylarginine Methyl Methylation A protein modification that effectively converts an L-cysteine residue to L-cysteine coenzyme A disulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2R)-2-amino-3-(2-((3-(((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino)-1-oxopropyl)amino)ethyl)dithio-propanoic acid 4'-ester with adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) L-cysteine coenzyme A disulfide SCoACys coenzyme A L-cysteine mixed disulfide PSI-MOD CoenzymeA Cysteine modified Coenzyme A MOD:00311 DeltaMass gives no formula with mass as 454. L-cysteine coenzyme A disulfide MOD:00311 A protein modification that effectively converts an L-cysteine residue to L-cysteine coenzyme A disulfide. DeltaMass:0 PubMed:1734967 RESID:AA0306 Unimod:281#C DiffAvg: 765.52 DiffFormula: C 21 H 34 N 7 O 16 P 3 S 1 DiffMono: 765.099559 Formula: C 24 H 39 N 8 O 17 P 3 S 2 MassAvg: 868.66 MassMono: 868.108744 Origin: C Source: hypothetical TermSpec: none Unimod: Unimod:281 (2R)-2-amino-3-(2-((3-(((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino)-1-oxopropyl)amino)ethyl)dithio-propanoic acid 4'-ester with adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) L-cysteine coenzyme A disulfide SCoACys coenzyme A L-cysteine mixed disulfide CoenzymeA Cysteine modified Coenzyme A A protein modification that effectively converts an L-cysteine residue to S-myristoyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (R)-2-amino-3-(tetradecanoylsulfanyl)propanoic acid LIPID S-myristoyl cysteine S-(C14:1 aliphatic acyl)cysteine S-myristoyl-L-cysteine S-myristoylated L-cysteine SMyrCys tetradecanoate cysteine thioester PSI-MOD Myristoyl Myristoylation MOD:00312 S-myristoyl-L-cysteine MOD:00312 A protein modification that effectively converts an L-cysteine residue to S-myristoyl-L-cysteine. PubMed:10026218 PubMed:10080938 PubMed:8824274 RESID:AA0307 Unimod:45#C DiffAvg: 210.36 DiffFormula: C 14 H 26 N 0 O 1 S 0 DiffMono: 210.198365 Formula: C 17 H 31 N 1 O 2 S 1 MassAvg: 313.50 MassMono: 313.207550 Origin: C Source: hypothetical TermSpec: none Unimod: Unimod:45 (R)-2-amino-3-(tetradecanoylsulfanyl)propanoic acid LIPID S-myristoyl cysteine S-(C14:1 aliphatic acyl)cysteine S-myristoyl-L-cysteine S-myristoylated L-cysteine SMyrCys tetradecanoate cysteine thioester Myristoyl Myristoylation A protein modification that effectively converts an L-cysteine residue to S-palmitoleyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0645 (R)-2-amino-3-((Z)-9-hexadecenoylsulfanyl)propanoic acid S-palmitoleyl-L-cysteine S-palmitoleylated L-cysteine SPamD1Cys cis-9-hexadecenoate cysteine thioester mod187 PSI-MOD Palmitoleyl palmitoleyl MOD:00313 S-palmitoleyl-L-cysteine MOD:00313 A protein modification that effectively converts an L-cysteine residue to S-palmitoleyl-L-cysteine. OMSSA:187 PubMed:8294460 RESID:AA0308 Unimod:431#C DiffAvg: 236.40 DiffFormula: C 16 H 28 N 0 O 1 S 0 DiffMono: 236.214016 Formula: C 19 H 33 N 1 O 2 S 1 MassAvg: 339.54 MassMono: 339.223200 Origin: C Source: hypothetical TermSpec: none Unimod: Unimod:431 (R)-2-amino-3-((Z)-9-hexadecenoylsulfanyl)propanoic acid S-palmitoleyl-L-cysteine S-palmitoleylated L-cysteine SPamD1Cys cis-9-hexadecenoate cysteine thioester mod187 Palmitoleyl palmitoleyl A protein modification that effectively converts a glycine residue to glycine cholesterol ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0090 LIPID Cholesterol glycine ester cholesteryl glycinate glycine cholest-5-en-3beta-ol ester glycine cholesterol ester hedgehog lipophilic adduct PSI-MOD C-cholesterol cholesterol ester MOD:00314 Incidental to RESID:AA0060. Unimod origin corrected [JSG]. glycine cholesterol ester MOD:00314 A protein modification that effectively converts a glycine residue to glycine cholesterol ester. ChEBI:143135 PubMed:11111088 PubMed:8824192 RESID:AA0309 Unimod:432#C-term DiffAvg: 368.65 DiffFormula: C 27 H 44 N 0 O 0 DiffMono: 368.344301 Formula: C 29 H 48 N 1 O 2 MassAvg: 442.71 MassMono: 442.368505 Origin: G Source: natural TermSpec: C-term Unimod: Unimod:432 LIPID Cholesterol glycine ester cholesteryl glycinate glycine cholest-5-en-3beta-ol ester glycine cholesterol ester hedgehog lipophilic adduct C-cholesterol cholesterol ester A protein modification that effectively converts five L-cysteine residues, an L-histidine residue and a one-nickel four-iron five-sulfur cluster to pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Nickel-iron-sulfur (Ni-4Fe-5S) METAL Nickel-iron-sulfur (Ni-4Fe-5S); via tele nitrogen Ni-4Fe-5S cluster carbon monoxide dehydrogenase nickel-iron cofactor mu-1:2kappaS-sulfido-mu3-1:3:5kappaS-sulfido-mu3-2:3:4kappaS-sulfido-mu3-2:4:5kappaS-sulfido-mu3-3:4:5kappaS-sulfido-N1'-histidino-S-cysteinyl-1-iron-S-cysteinyl-2-nickel-3,4,5-tris-(S-cysteinyl iron) pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide PSI-MOD MOD:00315 Cross-link 6. pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide MOD:00315 A protein modification that effectively converts five L-cysteine residues, an L-histidine residue and a one-nickel four-iron five-sulfur cluster to pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide. PubMed:11509720 PubMed:2550436 RESID:AA0310 DiffAvg: 436.33 DiffFormula: C 0 Fe 4 H -6 N 0 Ni 1 O 0 S 5 DiffMono: 435.488498 Formula: C 21 Fe 4 H 26 N 8 Ni 1 O 6 S 10 MassAvg: 1089.16 MassMono: 1087.593333 Origin: C, C, C, C, C, H Source: natural TermSpec: none METAL Nickel-iron-sulfur (Ni-4Fe-5S) METAL Nickel-iron-sulfur (Ni-4Fe-5S); via tele nitrogen Ni-4Fe-5S cluster carbon monoxide dehydrogenase nickel-iron cofactor mu-1:2kappaS-sulfido-mu3-1:3:5kappaS-sulfido-mu3-2:3:4kappaS-sulfido-mu3-2:4:5kappaS-sulfido-mu3-3:4:5kappaS-sulfido-N1'-histidino-S-cysteinyl-1-iron-S-cysteinyl-2-nickel-3,4,5-tris-(S-cysteinyl iron) pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide A protein modification that effectively converts an L-asparagine residue to N4,N4-dimethyl-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0182 (2S)-2-amino-4-(dimethylamino)-4-oxobutanoic acid 2-amino-N4,N4-dimethylbutanediamic acid MOD_RES N4,N4-dimethylasparagine N(gamma),N(gamma)-dimethylasparagine N4,N4-dimethyl-L-asparagine N4,N4-dimethylated L-asparagine N4Me2Asn PSI-MOD Dimethyl beta-dimethylasparagine di-Methylation MOD:00316 N4,N4-dimethyl-L-asparagine MOD:00316 A protein modification that effectively converts an L-asparagine residue to N4,N4-dimethyl-L-asparagine. PubMed:12964758 PubMed:14570711 PubMed:8783012 RESID:AA0311 Unimod:36#N DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 6 H 10 N 2 O 2 MassAvg: 142.16 MassMono: 142.074228 Origin: N Source: hypothetical TermSpec: none Unimod: Unimod:36 (2S)-2-amino-4-(dimethylamino)-4-oxobutanoic acid 2-amino-N4,N4-dimethylbutanediamic acid MOD_RES N4,N4-dimethylasparagine N(gamma),N(gamma)-dimethylasparagine N4,N4-dimethyl-L-asparagine N4,N4-dimethylated L-asparagine N4Me2Asn Dimethyl beta-dimethylasparagine di-Methylation A protein modification that effectively converts an L-lysine residue to N6-3,4-didehydroretinylidene-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid N6-(3,4-didehydroretinylidene)-L-lysine N6-3-dehydroretinal-L-lysine N6-3-dehydroretinyl-lysine PSI-MOD 3,4-didehydroretinylidene Didehydroretinylidene MOD:00317 N6-3,4-didehydroretinylidene-L-lysine MOD:00317 A protein modification that effectively converts an L-lysine residue to N6-3,4-didehydroretinylidene-L-lysine. PubMed:10717661 PubMed:3257009 PubMed:4056688 RESID:AA0312 Unimod:433#K DiffAvg: 264.41 DiffFormula: C 20 H 24 N 0 O 0 DiffMono: 264.187801 Formula: C 26 H 36 N 2 O 1 MassAvg: 392.59 MassMono: 392.282764 Origin: K Source: natural TermSpec: none Unimod: Unimod:433 (S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid N6-(3,4-didehydroretinylidene)-L-lysine N6-3-dehydroretinal-L-lysine N6-3-dehydroretinyl-lysine 3,4-didehydroretinylidene Didehydroretinylidene A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0041 (2R)-2-amino-3-[(3-[(2S)-2-amino-2-carboxyethyl]-6,7-dioxo-6,7-dihydro-1H-indol-4-yl)sulfanyl]propanoic acid 3-(2-amino-2-carboxyethyl)-4-[2-amino-2-carboxyethyl]sulfanyl-6,7-indolinedione 4'-(L-cystein-S-yl)-L-tryptophyl quinone 4-(S-cysteinyl)tryptophan-6,7-dione CROSSLNK 4'-cysteinyl-tryptophylquinone (Cys-Trp) CTQ cysteine tryptophylquinone PSI-MOD MOD:00318 Cross-link 2; secondary to RESID:AA0148. 4'-(S-L-cysteinyl)-L-tryptophyl quinone MOD:00318 A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone. PubMed:11555656 PubMed:11717396 RESID:AA0313 DiffAvg: 27.97 DiffFormula: C 0 H -4 N 0 O 2 S 0 DiffMono: 27.958529 Formula: C 14 H 11 N 3 O 4 S 1 MassAvg: 317.32 MassMono: 317.047027 Origin: C, W Source: natural TermSpec: none (2R)-2-amino-3-[(3-[(2S)-2-amino-2-carboxyethyl]-6,7-dioxo-6,7-dihydro-1H-indol-4-yl)sulfanyl]propanoic acid 3-(2-amino-2-carboxyethyl)-4-[2-amino-2-carboxyethyl]sulfanyl-6,7-indolinedione 4'-(L-cystein-S-yl)-L-tryptophyl quinone 4-(S-cysteinyl)tryptophan-6,7-dione CROSSLNK 4'-cysteinyl-tryptophylquinone (Cys-Trp) CTQ cysteine tryptophylquinone A protein modification that effectively cross-links an L-cysteine residue and an L-aspartic acid residue by a thioether bond to form 2-(S-L-cysteinyl)-L-aspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0025 (2R,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanedioic acid (2R,3S,6R)-2,6-diamino-3-carboxy-4-thiaheptanedioic acid 3-(L-cystein-S-yl)-L-aspartic acid 3-carboxy-L-lanthionine CROSSLNK 3-cysteinyl-aspartic acid (Cys-Asp) PSI-MOD MOD:00319 Cross-link 2. 3-(S-L-cysteinyl)-L-aspartic acid MOD:00319 A protein modification that effectively cross-links an L-cysteine residue and an L-aspartic acid residue by a thioether bond to form 2-(S-L-cysteinyl)-L-aspartic acid. PubMed:11555656 PubMed:11717396 RESID:AA0314 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 7 H 8 N 2 O 4 S 1 MassAvg: 216.21 MassMono: 216.020478 Origin: C, D Source: natural TermSpec: none (2R,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanedioic acid (2R,3S,6R)-2,6-diamino-3-carboxy-4-thiaheptanedioic acid 3-(L-cystein-S-yl)-L-aspartic acid 3-carboxy-L-lanthionine CROSSLNK 3-cysteinyl-aspartic acid (Cys-Asp) A protein modification that effectively cross-links an L-cysteine residue and an L-glutamic acid residue by a thioether bond to form 4-(S-L-cysteinyl)-L-glutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0040 (2S,3S,7R)-2,7-diamino-4-carboxy-5-thiaoctanedioic acid (2S,4S)-2-amino-4-[(R)-2-amino-2-carboxyethyl]sulfanylpentanedioic acid 4-(L-cystein-S-yl)-L-glutamic acid CROSSLNK 4-cysteinyl-glutamic acid (Cys-Glu) PSI-MOD MOD:00320 Cross-link 2. 4-(S-L-cysteinyl)-L-glutamic acid MOD:00320 A protein modification that effectively cross-links an L-cysteine residue and an L-glutamic acid residue by a thioether bond to form 4-(S-L-cysteinyl)-L-glutamic acid. ChEBI:20293 PubMed:11555656 PubMed:11717396 RESID:AA0315 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 8 H 10 N 2 O 4 S 1 MassAvg: 230.24 MassMono: 230.036128 Origin: C, E Source: natural TermSpec: none (2S,3S,7R)-2,7-diamino-4-carboxy-5-thiaoctanedioic acid (2S,4S)-2-amino-4-[(R)-2-amino-2-carboxyethyl]sulfanylpentanedioic acid 4-(L-cystein-S-yl)-L-glutamic acid CROSSLNK 4-cysteinyl-glutamic acid (Cys-Glu) A protein modification that effectively converts an L-aspartic acid residue to cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0091 (7Z,14Xi)-14-[(S)-3-amino-3-carboxy-propanoyl]oxy-10,13-dioxo-7-heptadecenoic acid LIPID Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester barley lipid transfer protein modification cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester PSI-MOD CHDH cis-14-hydroxy-10,13-dioxo-7-heptadecenoic ester MOD:00321 cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester MOD:00321 A protein modification that effectively converts an L-aspartic acid residue to cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester. PubMed:11435437 PubMed:7949339 RESID:AA0316 Unimod:434#D DiffAvg: 294.39 DiffFormula: C 17 H 26 N 0 O 4 DiffMono: 294.183109 Formula: C 21 H 31 N 1 O 7 MassAvg: 409.48 MassMono: 409.210052 Origin: D Source: natural TermSpec: none Unimod: Unimod:434 (7Z,14Xi)-14-[(S)-3-amino-3-carboxy-propanoyl]oxy-10,13-dioxo-7-heptadecenoic acid LIPID Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester barley lipid transfer protein modification cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester CHDH cis-14-hydroxy-10,13-dioxo-7-heptadecenoic ester A protein modification that effectively converts an L-histidine residue to tele-methyl-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0290 (S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid 1'-methyl-L-histidine MOD_RES Tele-methylhistidine N(epsilon)-methylhistidine N(tau)-methylhistidine NteleMeHis tele-methylated L-histidine tele-methylhistidine PSI-MOD 3-methylhistidine 4-methyl-histidine Methyl Methylation MOD:00322 1'-methyl-L-histidine MOD:00322 A protein modification that effectively converts an L-histidine residue to tele-methyl-L-histidine. PubMed:10601317 PubMed:11474090 PubMed:11875433 PubMed:6692818 PubMed:8076 PubMed:8645219 RESID:AA0317 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 9 N 3 O 1 MassAvg: 151.17 MassMono: 151.074562 Origin: H Source: natural TermSpec: none (S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid 1'-methyl-L-histidine MOD_RES Tele-methylhistidine N(epsilon)-methylhistidine N(tau)-methylhistidine NteleMeHis tele-methylated L-histidine tele-methylhistidine 3-methylhistidine 4-methyl-histidine Methyl Methylation A protein modification that effectively converts an L-lysine residue to L-lysine methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0170 2,6-diaminohexanoic methyl ester L-lysine methyl ester MOD_RES Lysine methyl ester OMeLys alpha,epsilon-diaminocaproic methyl ester methyl (S)-2,6-diaminohexanoate methyl L-lysinate methyl esterified L-lysine PSI-MOD Methyl Methylation MOD:00323 L-lysine methyl ester MOD:00323 A protein modification that effectively converts an L-lysine residue to L-lysine methyl ester. PubMed:10973948 PubMed:11875433 RESID:AA0318 Unimod:34#C-term DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 15 N 2 O 2 MassAvg: 159.21 MassMono: 159.113353 Origin: K Source: natural TermSpec: C-term Unimod: Unimod:34 2,6-diaminohexanoic methyl ester L-lysine methyl ester MOD_RES Lysine methyl ester OMeLys alpha,epsilon-diaminocaproic methyl ester methyl (S)-2,6-diaminohexanoate methyl L-lysinate methyl esterified L-lysine Methyl Methylation A protein modification that effectively converts an L-serine residue to L-serinyl molybdenum bis(molybdopterin guanine dinucleotide). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide L-serinyl molybdenum bis(molybdopterin guanine dinucleotide) bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-O3-serinyl-molybdenum oxide PSI-MOD MOD:00324 L-serinyl molybdenum bis(molybdopterin guanine dinucleotide) MOD:00324 A protein modification that effectively converts an L-serine residue to L-serinyl molybdenum bis(molybdopterin guanine dinucleotide). PubMed:8658132 PubMed:8658134 RESID:AA0319 DiffAvg: 1588.01 DiffFormula: C 40 H 47 Mo 1 N 20 O 27 P 4 S 4 DiffMono: 1588.980690 Formula: C 43 H 52 Mo 1 N 21 O 29 P 4 S 4 MassAvg: 1675.09 MassMono: 1676.012718 Origin: S Source: natural TermSpec: none 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide L-serinyl molybdenum bis(molybdopterin guanine dinucleotide) bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-O3-serinyl-molybdenum oxide A protein modification that effectively converts an L-asparagine residue to L-beta-methylthioasparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2R,3Xi)-2-amino-3-(methylsulfanyl)-4-butanediamic acid 2,4-diamino-3-(methylsulfanyl)-4-oxobutanoic acid 3-(methylthio)-L-asparagine 3-carboxamido-S-methyl-cysteine beta-(methylthio)asparagine PSI-MOD Beta-methylthiolation Methylthio MOD:00325 This modification was predicted for ribosomal protein S12 in Bacillus subtilis when the sequence in the original version of the genome was reported to have asparagine rather than aspartic acid at the position of the methylthioaspartic acid modification (see MOD:00237). Two groups independently confirmed that the genome sequence was incorrect. The sequence in the revised genome has aspartic acid at that position. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. L-beta-methylthioasparagine MOD:00325 A protein modification that effectively converts an L-asparagine residue to L-beta-methylthioasparagine. RESID:AA0320 Unimod:39#N DiffAvg: 46.09 DiffFormula: C 1 H 2 N 0 O 0 S 1 DiffMono: 45.987721 Formula: C 5 H 8 N 2 O 2 S 1 MassAvg: 160.19 MassMono: 160.030649 Origin: N Source: hypothetical TermSpec: none Unimod: Unimod:39 (2R,3Xi)-2-amino-3-(methylsulfanyl)-4-butanediamic acid 2,4-diamino-3-(methylsulfanyl)-4-oxobutanoic acid 3-(methylthio)-L-asparagine 3-carboxamido-S-methyl-cysteine beta-(methylthio)asparagine Beta-methylthiolation Methylthio A protein modification that effectively converts an L-lysine residue to L-pyrrolysine (not known as a natural, post-translational modification process). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid 2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid L-pyrrolysine N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine NON_STD Pyrrolysine Pyl(Lys) monomethylamine methyltransferase cofactor lysine adduct PSI-MOD MOD:00326 This entry is for the artifactual formation of L-pyrrolysine from lysine. For encoded L-pyrrolysine, use MOD:01187 [JSG]. L-pyrrolysine (Lys) MOD:00326 A protein modification that effectively converts an L-lysine residue to L-pyrrolysine (not known as a natural, post-translational modification process). PubMed:11435424 PubMed:12029131 PubMed:12029132 PubMed:15314242 PubMed:16096277 RESID:AA0321#LYS Unimod:435#K DiffAvg: 109.13 DiffFormula: C 6 H 7 N 1 O 1 DiffMono: 109.052764 Formula: C 12 H 19 N 3 O 2 MassAvg: 237.30 MassMono: 237.147727 Origin: K Source: artifact TermSpec: none Unimod: Unimod:435 (2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid 2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid L-pyrrolysine N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine NON_STD Pyrrolysine Pyl(Lys) monomethylamine methyltransferase cofactor lysine adduct A protein modification that effectively converts an L-tryptophan residue to a 3-hydroxy-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0031 (2S,3S)-2-amino-3-hydroxy-3-(1H-indol-3-yl)propanoic acid 3-hydroxy-L-tryptophan 3-hydroxylated L-tryptophan 3-hydroxytryptophan 3HyTrp MOD_RES 3-hydroxytryptophan beta-hydroxytryptophan PSI-MOD MOD:00327 3-hydroxy-L-tryptophan MOD:00327 A protein modification that effectively converts an L-tryptophan residue to a 3-hydroxy-L-tryptophan. ChEBI:141794 PubMed:10024453 PubMed:11457355 RESID:AA0322 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 11 H 10 N 2 O 2 MassAvg: 202.21 MassMono: 202.074228 Origin: W Source: hypothetical TermSpec: none (2S,3S)-2-amino-3-hydroxy-3-(1H-indol-3-yl)propanoic acid 3-hydroxy-L-tryptophan 3-hydroxylated L-tryptophan 3-hydroxytryptophan 3HyTrp MOD_RES 3-hydroxytryptophan beta-hydroxytryptophan A protein modification that effectively crosslinks an L-tyrosine residue and the 3'-end of DNA through a phosphodiester bond to form O4'-(phospho-3'-DNA)-L-tyrosine. Origin: Source: TermSpec: (S)-2-amino-3-[4-(3'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid ACT_SITE O-(3'-phospho-DNA)-tyrosine intermediate O4'-(phospho-3'-DNA)-L-tyrosine O4'-L-tyrosine 3'-DNA phosphodiester PSI-MOD MOD:00328 O4'-(phospho-3'-DNA)-L-tyrosine MOD:00328 A protein modification that effectively crosslinks an L-tyrosine residue and the 3'-end of DNA through a phosphodiester bond to form O4'-(phospho-3'-DNA)-L-tyrosine. PubMed:2211714 RESID:AA0323 Origin: Y Source: natural TermSpec: none (S)-2-amino-3-[4-(3'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid ACT_SITE O-(3'-phospho-DNA)-tyrosine intermediate O4'-(phospho-3'-DNA)-L-tyrosine O4'-L-tyrosine 3'-DNA phosphodiester A protein modification that effectively results from forming an adduct between a glutamic acid residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 5-hydroxymethyl protoporphyrin IX 5-glutamate ester BINDING Heme (covalent; via 1 link) [3-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-7,12-diethenyl-8,13,17-trimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate cytochrome P450 CYP4A family heme cofactor hydroxyheme-L-glutamate ester PSI-MOD Hydroxyheme hydroxyheme MOD:00329 hydroxyheme-L-glutamate ester MOD:00329 A protein modification that effectively results from forming an adduct between a glutamic acid residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. PubMed:11139583 PubMed:11821421 PubMed:11980497 RESID:AA0324 Unimod:436#E DiffAvg: 614.48 DiffFormula: C 34 Fe 1 H 30 N 4 O 4 DiffMono: 614.161643 Formula: C 39 Fe 1 H 37 N 5 O 7 MassAvg: 743.60 MassMono: 743.204236 Origin: E Source: natural TermSpec: none Unimod: Unimod:436 5-hydroxymethyl protoporphyrin IX 5-glutamate ester BINDING Heme (covalent; via 1 link) [3-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-7,12-diethenyl-8,13,17-trimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate cytochrome P450 CYP4A family heme cofactor hydroxyheme-L-glutamate ester Hydroxyheme hydroxyheme A protein modification that effectively converts an L-histidine residue to a (phospho-5'-guanosine)-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-3-(1-(5'-adenosine phosphono)imidazol-4-yl)propanoic acid 1'-(phospho-5'-guanosine)-L-histidine ACT_SITE GMP-histidine intermediate L-histidine 5'-guanosine phosphoramidester L-histidine monoanhydride with 5'-guanylic acid N(tau)-5'-guanylic-L-histidine N1'-guanylylated histidine tele-5'-guanylic-L-histidine PSI-MOD Phosphoguanosine phospho-guanosine MOD:00330 (phospho-5'-guanosine)-L-histidine MOD:00330 A protein modification that effectively converts an L-histidine residue to a (phospho-5'-guanosine)-L-histidine. PubMed:10529169 PubMed:10869342 PubMed:7559521 RESID:AA0325 Unimod:413#H DiffAvg: 345.21 DiffFormula: C 10 H 12 N 5 O 7 P 1 DiffMono: 345.047434 Formula: C 16 H 19 N 8 O 8 P 1 MassAvg: 482.35 MassMono: 482.106346 Origin: H Source: natural TermSpec: none Unimod: Unimod:413 (2S)-2-amino-3-(1-(5'-adenosine phosphono)imidazol-4-yl)propanoic acid 1'-(phospho-5'-guanosine)-L-histidine ACT_SITE GMP-histidine intermediate L-histidine 5'-guanosine phosphoramidester L-histidine monoanhydride with 5'-guanylic acid N(tau)-5'-guanylic-L-histidine N1'-guanylylated histidine tele-5'-guanylic-L-histidine Phosphoguanosine phospho-guanosine A protein modification that effectively converts four L-cysteine residues and a three-iron four-sulfur cluster to tetrakis-L-cysteinyl triiron tetrasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: bis[bis-L-cysteinyl iron disulfido]iron di-mu-1:2kappaS-sulfido di-mu-2:3kappaS-sulfido iron bis(bis-S-cysteinyliron) tetra-mu-sulfido tetrakis-S-L-cysteinyl triiron tetrakis-L-cysteinyl linear [3Fe-4S] cluster tetrakis-L-cysteinyl triiron tetrasulfide tetrakis-L-cysteinyl triiron tetrasulfide D2 cluster PSI-MOD MOD:00331 Cross-link 4. tetrakis-L-cysteinyl triiron tetrasulfide MOD:00331 A protein modification that effectively converts four L-cysteine residues and a three-iron four-sulfur cluster to tetrakis-L-cysteinyl triiron tetrasulfide. PubMed:11592901 PubMed:11941493 PubMed:2511202 PubMed:6094558 RESID:AA0326 DiffAvg: 291.74 DiffFormula: C 0 Fe 3 H -4 N 0 O 0 S 4 DiffMono: 291.663442 FormalCharge: 3- Formula: C 12 Fe 3 H 16 N 4 O 4 S 8 MassAvg: 704.30 MassMono: 703.700181 Origin: C, C, C, C Source: hypothetical TermSpec: none bis[bis-L-cysteinyl iron disulfido]iron di-mu-1:2kappaS-sulfido di-mu-2:3kappaS-sulfido iron bis(bis-S-cysteinyliron) tetra-mu-sulfido tetrakis-S-L-cysteinyl triiron tetrakis-L-cysteinyl linear [3Fe-4S] cluster tetrakis-L-cysteinyl triiron tetrasulfide tetrakis-L-cysteinyl triiron tetrasulfide D2 cluster A protein modification that effectively converts an L-arginine residue to N4-glucosyl-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0515 (2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid CARBOHYD N-linked (Glc) arginine NG-beta-D-glucosylarginine omega-N-(beta-D-glucosyl)-L-arginine omega-N-glucosyl-L-arginine omega-N-glycosyl-L-arginine PSI-MOD Hex Hexose MOD:00332 omega-N-glucosyl-L-arginine MOD:00332 A protein modification that effectively converts an L-arginine residue to N4-glucosyl-arginine. PubMed:15279557 PubMed:8521968 PubMed:9536051 RESID:AA0327 Unimod:41#R DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 12 H 22 N 4 O 6 MassAvg: 318.33 MassMono: 318.153934 Origin: R Source: natural TermSpec: none Unimod: Unimod:41 (2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid CARBOHYD N-linked (Glc) arginine NG-beta-D-glucosylarginine omega-N-(beta-D-glucosyl)-L-arginine omega-N-glucosyl-L-arginine omega-N-glycosyl-L-arginine Hex Hexose A protein modification that effectively converts an L-asparagine residue to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0335 (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine 5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]adenosine 9-(5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]-beta-D-ribofuranosyl)adenine MOD_RES Aspartic acid 1-[(3-aminopropyl)(5'-adenosyl)phosphono]amide N-(aspart-1-yl)-O-(3-aminopropyl)-O-(5'-adenosyl)phosphoramide microcin C7 asparagine modification PSI-MOD (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5-adenosine C-Asn-deriv MOD:00333 Unimod origin shown as C-term [JSG]. (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine MOD:00333 A protein modification that effectively converts an L-asparagine residue to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine. PubMed:7559516 PubMed:7835418 PubMed:8183363 RESID:AA0328 Unimod:437#C-term DiffAvg: 386.30 DiffFormula: C 13 H 19 N 6 O 6 P 1 DiffMono: 386.110369 Formula: C 17 H 26 N 8 O 9 P 1 MassAvg: 517.42 MassMono: 517.156036 Origin: N Source: natural TermSpec: C-term Unimod: Unimod:437 (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine 5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]adenosine 9-(5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]-beta-D-ribofuranosyl)adenine MOD_RES Aspartic acid 1-[(3-aminopropyl)(5'-adenosyl)phosphono]amide N-(aspart-1-yl)-O-(3-aminopropyl)-O-(5'-adenosyl)phosphoramide microcin C7 asparagine modification (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5-adenosine C-Asn-deriv A protein modification that effectively results from forming an adduct between the tele nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (S)-[7-ethenyl-12-[1-((2-amino-2-carboxyethyl)-1H-imidazol-1-yl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate 1'-heme-L-histidine 2-[1-(N1'-histidyl)ethyl]protoporphyrin IX BINDING Heme (covalent; via tele nitrogen) N(epsilon)-histidyl heme N(tau)-histidyl heme N1'-histidyl heme tele-histidyl heme PSI-MOD Heme heme MOD:00334 1'-heme-L-histidine MOD:00334 A protein modification that effectively results from forming an adduct between the tele nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron. PubMed:12033922 PubMed:12121092 RESID:AA0329 Unimod:390#H DiffAvg: 616.50 DiffFormula: C 34 Fe 1 H 32 N 4 O 4 DiffMono: 616.177293 Formula: C 40 Fe 1 H 39 N 7 O 5 MassAvg: 753.64 MassMono: 753.236205 Origin: H Source: hypothetical TermSpec: none Unimod: Unimod:390 (S)-[7-ethenyl-12-[1-((2-amino-2-carboxyethyl)-1H-imidazol-1-yl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate 1'-heme-L-histidine 2-[1-(N1'-histidyl)ethyl]protoporphyrin IX BINDING Heme (covalent; via tele nitrogen) N(epsilon)-histidyl heme N(tau)-histidyl heme N1'-histidyl heme tele-histidyl heme Heme heme A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine sulfoxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0069 (2S,3S,4Xi,6R)-2,6-diamino-3-methyl-4-oxo-4-thiaheptanedioic acid (2S,3S,SXi)-2-amino-3-([(R)-2-amino-2-carboxyethyl]sulfinyl)butanoic acid 3-methyl-L-lanthionine S-oxide 3-methyl-L-lanthionine sulfoxide CROSSLNK Beta-methyllanthionine sulfoxide (Thr-Cys) S-oxy-3-methyllanthionine PSI-MOD MOD:00335 Cross-link 2. (2S,3S,2'R)-3-methyllanthionine sulfoxide MOD:00335 A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine sulfoxide. PubMed:7737178 PubMed:9219543 RESID:AA0330 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 7 H 10 N 2 O 3 S 1 MassAvg: 202.23 MassMono: 202.041213 Origin: C, T Source: natural TermSpec: none (2S,3S,4Xi,6R)-2,6-diamino-3-methyl-4-oxo-4-thiaheptanedioic acid (2S,3S,SXi)-2-amino-3-([(R)-2-amino-2-carboxyethyl]sulfinyl)butanoic acid 3-methyl-L-lanthionine S-oxide 3-methyl-L-lanthionine sulfoxide CROSSLNK Beta-methyllanthionine sulfoxide (Thr-Cys) S-oxy-3-methyllanthionine A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-aspartato diiron disulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (2Fe-2S) di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-O4-aspartatoiron) tris-L-cysteinyl L-aspartato diiron disulfide PSI-MOD MOD:00336 Cross-link 4. tris-L-cysteinyl L-aspartato diiron disulfide MOD:00336 A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-aspartato diiron disulfide. PubMed:10968624 PubMed:1312028 PubMed:7947772 RESID:AA0331 DiffAvg: 171.78 DiffFormula: C 0 Fe 2 H -4 N 0 O 0 S 2 DiffMono: 171.783814 FormalCharge: 2- Formula: C 13 Fe 2 H 16 N 4 O 6 S 5 MassAvg: 596.28 MassMono: 595.838311 Origin: C, C, C, D Source: hypothetical TermSpec: none METAL Iron-sulfur (2Fe-2S) di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-O4-aspartatoiron) tris-L-cysteinyl L-aspartato diiron disulfide A protein modification that effectively converts an L-cysteine residue to S-carbamoyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0649 (R)-2-amino-3-(carbamoylsulfanyl)propanoic acid 2-amino-3-(aminocarbonyl)sulfanylpropanoic acid 2-amino-3-(aminocarbonyl)thiopropanoic acid MOD_RES S-carbamoylcysteine S-(aminocarbonyl)cysteine S-carbamoyl-L-cysteine S-carbamoylcysteine S-carbamylcysteine S-cysteinyl carbamate ester SCbmCys alpha-amino-beta-carbamylthiopropionic acid beta-carbamylthioalanine PSI-MOD MOD:00337 S-carbamoyl-L-cysteine MOD:00337 A protein modification that effectively converts an L-cysteine residue to S-carbamoyl-L-cysteine. PubMed:12586941 PubMed:240389 RESID:AA0332 Unimod:5#C DiffAvg: 43.02 DiffFormula: C 1 H 1 N 1 O 1 S 0 DiffMono: 43.005814 Formula: C 4 H 6 N 2 O 2 S 1 MassAvg: 146.16 MassMono: 146.014998 Origin: C Source: natural TermSpec: none Unimod: Unimod:5 (R)-2-amino-3-(carbamoylsulfanyl)propanoic acid 2-amino-3-(aminocarbonyl)sulfanylpropanoic acid 2-amino-3-(aminocarbonyl)thiopropanoic acid MOD_RES S-carbamoylcysteine S-(aminocarbonyl)cysteine S-carbamoyl-L-cysteine S-carbamoylcysteine S-carbamylcysteine S-cysteinyl carbamate ester SCbmCys alpha-amino-beta-carbamylthiopropionic acid beta-carbamylthioalanine A protein modification that effectively converts an L-cysteine residue to S-cyano-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0650 (2R)-2-amino-3-thiocyanatopropanoic acid MOD_RES S-cyanocysteine S-cyano-L-cysteine S-cyanocysteine alpha-amino-beta-thiocyanatopropionic acid beta-thiocyanatoalanine serine thiocyanic acid ester PSI-MOD Cyano cyano MOD:00338 S-cyano-L-cysteine MOD:00338 A protein modification that effectively converts an L-cysteine residue to S-cyano-L-cysteine. PubMed:12586941 PubMed:4808702 RESID:AA0333 Unimod:438#C DiffAvg: 25.01 DiffFormula: C 1 H -1 N 1 O 0 S 0 DiffMono: 24.995249 Formula: C 4 H 4 N 2 O 1 S 1 MassAvg: 128.15 MassMono: 128.004434 Origin: C Source: natural TermSpec: none Unimod: Unimod:438 (2R)-2-amino-3-thiocyanatopropanoic acid MOD_RES S-cyanocysteine S-cyano-L-cysteine S-cyanocysteine alpha-amino-beta-thiocyanatopropionic acid beta-thiocyanatoalanine serine thiocyanic acid ester Cyano cyano A protein modification that effectively converts an L-cysteine residue to L-cysteinyl hydrogenase diiron subcluster. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 1,7-biscarbonyl-1-(cystein-S-yl)-8-oxo-4-aza-2lambda(3),6 lambda(3)-dithia-1,7-diferratricyclo[4.2.0.0(2,7)]octane-1,7-dicarbonitrile L-cysteinyl hydrogenase diiron subcluster METAL Diiron subcluster mu-carbonyl-dicarbonyl-1kappaC,2kappaC-dicyanido-1kappaC,2kappaC-cysteinato-1kS-1,2-azadimethanthiol-1kS,2kS'-diiron PSI-MOD Diironsubcluster hydrogenase diiron subcluster MOD:00339 incidental to RESID:AA0140. L-cysteinyl hydrogenase diiron subcluster MOD:00339 A protein modification that effectively converts an L-cysteine residue to L-cysteinyl hydrogenase diiron subcluster. PubMed:10694885 PubMed:9836629 RESID:AA0334 Unimod:439#C DiffAvg: 342.87 DiffFormula: C 5 Fe 2 H -1 N 2 O 5 S 2 DiffMono: 342.786913 Formula: C 8 Fe 2 H 4 N 3 O 6 S 3 MassAvg: 446.01 MassMono: 445.796098 Origin: C Source: natural TermSpec: none Unimod: Unimod:439 1,7-biscarbonyl-1-(cystein-S-yl)-8-oxo-4-aza-2lambda(3),6 lambda(3)-dithia-1,7-diferratricyclo[4.2.0.0(2,7)]octane-1,7-dicarbonitrile L-cysteinyl hydrogenase diiron subcluster METAL Diiron subcluster mu-carbonyl-dicarbonyl-1kappaC,2kappaC-dicyanido-1kappaC,2kappaC-cysteinato-1kS-1,2-azadimethanthiol-1kS,2kS'-diiron Diironsubcluster hydrogenase diiron subcluster A protein modification that effectively converts an L-cysteine residue to S-amidino-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2R)-2-amino-3-(carbamimidoylsulfanyl)propanoic acid 2-amino-3-amidinosulfanylpropanoic acid 2-amino-3-amidinothiopropanoic acid ACT_SITE Amidino-cysteine intermediate S-amidino-L-cysteine S-amidinocysteine alpha-amino-beta-amidinothiopropionic acid beta-(S-isothiourea)alanine beta-amidinothioalanine PSI-MOD Amidino amidino MOD:00340 S-amidino-L-cysteine MOD:00340 A protein modification that effectively converts an L-cysteine residue to S-amidino-L-cysteine. PubMed:9148748 RESID:AA0335 Unimod:440#C DiffAvg: 42.04 DiffFormula: C 1 H 2 N 2 O 0 S 0 DiffMono: 42.021798 Formula: C 4 H 7 N 3 O 1 S 1 MassAvg: 145.18 MassMono: 145.030983 Origin: C Source: natural TermSpec: none Unimod: Unimod:440 (2R)-2-amino-3-(carbamimidoylsulfanyl)propanoic acid 2-amino-3-amidinosulfanylpropanoic acid 2-amino-3-amidinothiopropanoic acid ACT_SITE Amidino-cysteine intermediate S-amidino-L-cysteine S-amidinocysteine alpha-amino-beta-amidinothiopropionic acid beta-(S-isothiourea)alanine beta-amidinothioalanine Amidino amidino A protein modification that effectively converts an L-isoleucine residue to N-methyl-L-isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0215 (2S,3S)-2-methylamino-3-methylpentanoic acid MOD_RES N-methylisoleucine N-methyl-L-isoleucine N-methylated L-isoleucine N-methylisoleucine NMe1Ile PSI-MOD Methyl Methylation MOD:00341 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-isoleucine MOD:00341 A protein modification that effectively converts an L-isoleucine residue to N-methyl-L-isoleucine. PubMed:11875433 RESID:AA0336 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 13 N 1 O 1 MassAvg: 127.19 MassMono: 127.099714 Origin: I Source: hypothetical TermSpec: none (2S,3S)-2-methylamino-3-methylpentanoic acid MOD_RES N-methylisoleucine N-methyl-L-isoleucine N-methylated L-isoleucine N-methylisoleucine NMe1Ile Methyl Methylation A protein modification that effectively converts an L-leucine residue to N-methyl-L-leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0216 (S)-2-methylamino-4-methylpentanoic acid 2-(methylamino)-4-methyl-valeric acid MOD_RES N-methylleucine N-methyl-L-leucine N-methylated L-leucine N-methylleucine NMe1Leu PSI-MOD Methyl Methylation MOD:00342 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-leucine MOD:00342 A protein modification that effectively converts an L-leucine residue to N-methyl-L-leucine. PubMed:11875433 RESID:AA0337 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 13 N 1 O 1 MassAvg: 127.19 MassMono: 127.099714 Origin: L Source: hypothetical TermSpec: none (S)-2-methylamino-4-methylpentanoic acid 2-(methylamino)-4-methyl-valeric acid MOD_RES N-methylleucine N-methyl-L-leucine N-methylated L-leucine N-methylleucine NMe1Leu Methyl Methylation A protein modification that effectively converts an L-tyrosine residue to N-methyl-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0220 (2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid MOD_RES N-methyltyrosine N-methyl Tyrosinyl N-methyl-L-tyrosine N-methylated L-tyrosine N-methyltyrosine NMe1Tyr PSI-MOD Methyl MOD:00343 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-tyrosine MOD:00343 A protein modification that effectively converts an L-tyrosine residue to N-methyl-L-tyrosine. DeltaMass:0 RESID:AA0338 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 10 H 11 N 1 O 2 MassAvg: 177.20 MassMono: 177.078979 Origin: Y Source: hypothetical TermSpec: none (2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid MOD_RES N-methyltyrosine N-methyl Tyrosinyl N-methyl-L-tyrosine N-methylated L-tyrosine N-methyltyrosine NMe1Tyr Methyl A protein modification that effectively converts a glycine residue to N-palmitoylglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0223 (hexadecanamido)acetic acid (hexadecanoylamino)acetic acid (hexadecanoylamino)ethanoic acid LIPID N-palmitoyl glycine N-(1-oxohexadecyl)glycine N-hexadecanoylated glycine N-palmitoyl-glycine N-palmitoylated glycine NPamGly PSI-MOD MOD:00344 incidental to RESID:AA0060 N-palmitoylglycine MOD:00344 A protein modification that effectively converts a glycine residue to N-palmitoylglycine. PubMed:12574119 RESID:AA0339 DiffAvg: 238.41 DiffFormula: C 16 H 30 N 0 O 1 S 0 DiffMono: 238.229666 Formula: C 18 H 34 N 1 O 2 MassAvg: 296.47 MassMono: 296.258954 Origin: G Source: natural TermSpec: N-term (hexadecanamido)acetic acid (hexadecanoylamino)acetic acid (hexadecanoylamino)ethanoic acid LIPID N-palmitoyl glycine N-(1-oxohexadecyl)glycine N-hexadecanoylated glycine N-palmitoyl-glycine N-palmitoylated glycine NPamGly A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0012 (2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid (2R,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid 2-(L-cystein-S-yl)-L-phenylalanine CROSSLNK 2-cysteinyl-L-phenylalanine (Cys-Phe) alpha-(L-cystein-S-yl)-L-phenylalanine PSI-MOD MOD:00345 Cross-link 2. 2-(S-L-cysteinyl)-L-phenylalanine MOD:00345 A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-phenylalanine. PubMed:12696888 PubMed:3936839 RESID:AA0340 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 12 H 12 N 2 O 2 S 1 MassAvg: 248.30 MassMono: 248.061949 Origin: C, F Source: natural TermSpec: none (2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid (2R,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid 2-(L-cystein-S-yl)-L-phenylalanine CROSSLNK 2-cysteinyl-L-phenylalanine (Cys-Phe) alpha-(L-cystein-S-yl)-L-phenylalanine A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0011 (2S)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid (2S,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid 2-(L-cystein-S-yl)-D-phenylalanine CROSSLNK 2-cysteinyl-D-phenylalanine (Cys-Phe) alpha-(L-cystein-S-yl)-D-phenylalanine PSI-MOD MOD:00346 Cross-link 2. 2-(S-L-cysteinyl)-D-phenylalanine MOD:00346 A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-phenylalanine. PubMed:12696888 PubMed:3936839 RESID:AA0341 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 12 H 12 N 2 O 2 S 1 MassAvg: 248.30 MassMono: 248.061949 Origin: C, F Source: natural TermSpec: none (2S)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid (2S,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid 2-(L-cystein-S-yl)-D-phenylalanine CROSSLNK 2-cysteinyl-D-phenylalanine (Cys-Phe) alpha-(L-cystein-S-yl)-D-phenylalanine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-allo-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0010 (2R,5S,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid (2S,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid 2-(L-cystein-S-yl)-D-allo-threonine CROSSLNK 2-cysteinyl-D-allo-threonine (Cys-Thr) alpha-(L-cystein-S-yl)-D-allo-threonine PSI-MOD MOD:00347 Cross-link 2. 2-(S-L-cysteinyl)-D-allo-threonine MOD:00347 A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-allo-threonine. PubMed:12696888 PubMed:3936839 RESID:AA0342 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 7 H 10 N 2 O 3 S 1 MassAvg: 202.23 MassMono: 202.041213 Origin: C, T Source: natural TermSpec: none (2R,5S,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid (2S,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid 2-(L-cystein-S-yl)-D-allo-threonine CROSSLNK 2-cysteinyl-D-allo-threonine (Cys-Thr) alpha-(L-cystein-S-yl)-D-allo-threonine A protein modification that effectively converts an L-alanine residue to N-carbamoyl-L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0374 (S)-2-(carbamoylamino)propanoic acid 2-ureidopropanoic acid MOD_RES N-carbamoylalanine N-carbamoyl-L-alanine N-carbamylalanine N2CbmAla PSI-MOD MOD:00348 N-carbamoyl-L-alanine MOD:00348 A protein modification that effectively converts an L-alanine residue to N-carbamoyl-L-alanine. PubMed:12203680 RESID:AA0343 DiffAvg: 43.02 DiffFormula: C 1 H 1 N 1 O 1 DiffMono: 43.005814 Formula: C 4 H 7 N 2 O 2 MassAvg: 115.11 MassMono: 115.050752 Origin: A Source: natural TermSpec: N-term (S)-2-(carbamoylamino)propanoic acid 2-ureidopropanoic acid MOD_RES N-carbamoylalanine N-carbamoyl-L-alanine N-carbamylalanine N2CbmAla A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form 4-amino-3-isothiazolidinone-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0037 (2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-hydroxypropanoic acid 2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-hydroxy-propanoic acid 4-amino-3-isothiazolidinone-L-serine CROSSLNK N,N-(cysteine-1,S-diyl)serine (Cys-Ser) N,N-(L-cysteine-1,S-diyl)-L-serine serine-cysteine sulfenyl amide cross-link serine-cysteine sulphenyl amide cross-link PSI-MOD MOD:00349 Cross-link 2. 4-amino-3-isothiazolidinone-L-serine MOD:00349 A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form 4-amino-3-isothiazolidinone-L-serine. PubMed:12802338 PubMed:12802339 RESID:AA0344 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 6 H 8 N 2 O 3 S 1 MassAvg: 188.20 MassMono: 188.025563 Origin: C, S Source: natural TermSpec: none (2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-hydroxypropanoic acid 2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-hydroxy-propanoic acid 4-amino-3-isothiazolidinone-L-serine CROSSLNK N,N-(cysteine-1,S-diyl)serine (Cys-Ser) N,N-(L-cysteine-1,S-diyl)-L-serine serine-cysteine sulfenyl amide cross-link serine-cysteine sulphenyl amide cross-link A protein modification that effectively attaches an L-threonine residue to murein peptidoglycan by a pentaglycine linker peptide. Origin: Source: TermSpec: uniprot.ptm:PTM-0246 (2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(threonyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine L-threonyl-pentaglycyl-murein peptidoglycan MOD_RES Pentaglycyl murein peptidoglycan amidated threonine PSI-MOD MOD:00350 L-threonyl-pentaglycyl-murein peptidoglycan MOD:00350 A protein modification that effectively attaches an L-threonine residue to murein peptidoglycan by a pentaglycine linker peptide. PubMed:10754567 PubMed:1638631 RESID:AA0345 Origin: T Source: natural TermSpec: C-term (2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(threonyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine L-threonyl-pentaglycyl-murein peptidoglycan MOD_RES Pentaglycyl murein peptidoglycan amidated threonine A protein modification that effectively converts a glycine residue to N-glycyl-1-(phosphatidyl)ethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0249 (R)-1-hexadecanoyloxy-2-((Z)-9-octadecenoyloxy)-3-[2-(aminoacetylamino)ethyloxyphospho]propane LIPID Phosphatidylethanolamine amidated glycine N-glycyl-1-(phosphatidyl)ethanolamine N-glycyl-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine PSI-MOD MOD:00351 N-glycyl-1-(phosphatidyl)ethanolamine MOD:00351 A protein modification that effectively converts a glycine residue to N-glycyl-1-(phosphatidyl)ethanolamine. PubMed:11100732 RESID:AA0346 DiffAvg: 699.99 DiffFormula: C 39 H 74 N 1 O 7 P 1 DiffMono: 699.520290 Formula: C 41 H 78 N 2 O 9 P 1 MassAvg: 774.05 MassMono: 773.544494 Origin: G Source: natural TermSpec: C-term (R)-1-hexadecanoyloxy-2-((Z)-9-octadecenoyloxy)-3-[2-(aminoacetylamino)ethyloxyphospho]propane LIPID Phosphatidylethanolamine amidated glycine N-glycyl-1-(phosphatidyl)ethanolamine N-glycyl-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-omega-hydroxyceramide ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0236 (S)-2-amino-5-[30-((2S,3R,4E)-1,3-dihydroxyicos-4-en-2-ylamino)-30-oxotriacontan-1-yloxy]-5-oxopentanoic acid 2-[30-(isoglutamyloxy)triacontanoyl]icosasphingosine L-glutamyl 5-omega-hydroxyceramide ester LIPID Omega-hydroxyceramide glutamate ester PSI-MOD MOD:00352 L-glutamyl 5-omega-hydroxyceramide ester MOD:00352 A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-omega-hydroxyceramide ester. PubMed:10411887 PubMed:9651377 RESID:AA0347 DiffAvg: 761.31 DiffFormula: C 50 H 96 N 0 O 4 DiffMono: 760.730862 Formula: C 55 H 104 N 2 O 6 MassAvg: 889.44 MassMono: 888.789439 Origin: Q Source: natural TermSpec: none (S)-2-amino-5-[30-((2S,3R,4E)-1,3-dihydroxyicos-4-en-2-ylamino)-30-oxotriacontan-1-yloxy]-5-oxopentanoic acid 2-[30-(isoglutamyloxy)triacontanoyl]icosasphingosine L-glutamyl 5-omega-hydroxyceramide ester LIPID Omega-hydroxyceramide glutamate ester A protein modification that effectively cross-links an L-tryptophan residue with an L-tyrosine residue by a carbon-carbon bond, and cross-links the L-tyrosine residue to an L-methionine residue by a thioether bond to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0328 5'-(6'-tryptophyl)-tyrosin-3'-yl-methionin-S-ium S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium PSI-MOD MOD:00353 Cross-link 3. S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium MOD:00353 A protein modification that effectively cross-links an L-tryptophan residue with an L-tyrosine residue by a carbon-carbon bond, and cross-links the L-tyrosine residue to an L-methionine residue by a thioether bond to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium. PubMed:12172540 PubMed:16285713 RESID:AA0348 DiffAvg: -3.02 DiffFormula: C 0 H -3 N 0 O 0 S 0 DiffMono: -3.024024 FormalCharge: 1+ Formula: C 25 H 25 N 4 O 4 S 1 MassAvg: 477.56 MassMono: 477.159103 Origin: M, W, Y Source: natural TermSpec: none 5'-(6'-tryptophyl)-tyrosin-3'-yl-methionin-S-ium S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium A protein modification that effectively converts an L-threonine residue to O-(riboflavin phosphoryl)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0126 (2S,3R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)butanoic acid MOD_RES FMN phosphoryl threonine O-(riboflavin phosphoryl)-L-threonine O3-threonyl FMN O3-threonyl flavin mononucleotide OFMNThr PSI-MOD FMN O3-(riboflavin phosphoryl) MOD:00354 O-(riboflavin phosphoryl)-L-threonine MOD:00354 A protein modification that effectively converts an L-threonine residue to O-(riboflavin phosphoryl)-L-threonine. PubMed:10587447 PubMed:11163785 PubMed:11248234 RESID:AA0349 Unimod:442#T DiffAvg: 438.33 DiffFormula: C 17 H 19 N 4 O 8 P 1 DiffMono: 438.094050 Formula: C 21 H 26 N 5 O 10 P 1 MassAvg: 539.44 MassMono: 539.141729 Origin: T Source: natural TermSpec: none Unimod: Unimod:442 (2S,3R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)butanoic acid MOD_RES FMN phosphoryl threonine O-(riboflavin phosphoryl)-L-threonine O3-threonyl FMN O3-threonyl flavin mononucleotide OFMNThr FMN O3-(riboflavin phosphoryl) A protein modification that effectively converts an L-serine residue to O-(riboflavin phosphoryl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0125 (R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)propanoic acid MOD_RES FMN phosphoryl serine O-(riboflavin phosphoryl)-L-serine O3-seryl FMN O3-seryl flavin mononucleotide OFMNSer PSI-MOD FMN O3-(riboflavin phosphoryl) MOD:00355 O-(riboflavin phosphoryl)-L-serine MOD:00355 A protein modification that effectively converts an L-serine residue to O-(riboflavin phosphoryl)-L-serine. RESID:AA0350 Unimod:442#S DiffAvg: 438.33 DiffFormula: C 17 H 19 N 4 O 8 P 1 DiffMono: 438.094050 Formula: C 20 H 24 N 5 O 10 P 1 MassAvg: 525.41 MassMono: 525.126079 Origin: S Source: natural TermSpec: none Unimod: Unimod:442 (R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)propanoic acid MOD_RES FMN phosphoryl serine O-(riboflavin phosphoryl)-L-serine O3-seryl FMN O3-seryl flavin mononucleotide OFMNSer FMN O3-(riboflavin phosphoryl) A protein modification that effectively converts an L-cysteine residue to S-(4a-FMN)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0270 (R)-2-amino-3-(4a-riboflavin 5'-dihydrogen phosphate)sulfanylpropanoic acid 4a-(S-cysteinyl)FMN 4a-(S-cysteinyl)flavin mononucleotide MOD_RES S-4a-FMN cysteine S-(4a-FMN)-L-cysteine S4aFMNCys PSI-MOD FMNC S-(4a-FMN) MOD:00356 S-(4alpha-FMN)-L-cysteine MOD:00356 A protein modification that effectively converts an L-cysteine residue to S-(4a-FMN)-L-cysteine. PubMed:12668455 PubMed:12846567 PubMed:7692961 RESID:AA0351 Unimod:443#C DiffAvg: 456.35 DiffFormula: C 17 H 21 N 4 O 9 P 1 S 0 DiffMono: 456.104615 Formula: C 20 H 26 N 5 O 10 P 1 S 1 MassAvg: 559.49 MassMono: 559.113800 Origin: C Source: natural TermSpec: none Unimod: Unimod:443 (R)-2-amino-3-(4a-riboflavin 5'-dihydrogen phosphate)sulfanylpropanoic acid 4a-(S-cysteinyl)FMN 4a-(S-cysteinyl)flavin mononucleotide MOD_RES S-4a-FMN cysteine S-(4a-FMN)-L-cysteine S4aFMNCys FMNC S-(4a-FMN) A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FMN)-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0289 (S)-2-amino-3-(1-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid 1'-(8alpha-FMN)-L-histidine 8alpha-(N(epsilon)-histidyl)FMN 8alpha-(N1'-histidyl)FMN MOD_RES Tele-8alpha-FMN histidine N(tau)-(8alpha-FMN)-histidine Ntele8aFMNHis tele-(8alpha-FMN)-histidine PSI-MOD FMNH flavin mononucleotide MOD:00357 1'-(8alpha-FMN)-L-histidine MOD:00357 A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FMN)-L-histidine. PubMed:11902668 PubMed:8611516 RESID:AA0352 Unimod:409#H DiffAvg: 454.33 DiffFormula: C 17 H 19 N 4 O 9 P 1 DiffMono: 454.088965 Formula: C 23 H 26 N 7 O 10 P 1 MassAvg: 591.47 MassMono: 591.147877 Origin: H Source: natural TermSpec: none Unimod: Unimod:409 (S)-2-amino-3-(1-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid 1'-(8alpha-FMN)-L-histidine 8alpha-(N(epsilon)-histidyl)FMN 8alpha-(N1'-histidyl)FMN MOD_RES Tele-8alpha-FMN histidine N(tau)-(8alpha-FMN)-histidine Ntele8aFMNHis tele-(8alpha-FMN)-histidine FMNH flavin mononucleotide A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FMN)-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (S)-2-amino-3-(3-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid 3'-(8alpha-FMN)-L-histidine 8alpha-(N(delta)-histidyl)FMN 8alpha-(N3'-histidyl)FMN N(pi)-(8alpha-FMN)-histidine Npros8aFMNHis pros-(8alpha-FMN)-histidine PSI-MOD FMNH flavin mononucleotide MOD:00358 In a later publication, PubMed:19438211, the authors changed the enzyme activity, the connection from a histidine nitrogen to a cysteine sulfur, and the identity of the flavin from FMN to FAD. They now believe the modification is S-(8alpha-FAD)-L-cysteine, see MOD:00152. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. 3'-(8alpha-FMN)-L-histidine MOD:00358 A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FMN)-L-histidine. PubMed:12417325 RESID:AA0353 Unimod:409#H DiffAvg: 454.33 DiffFormula: C 17 H 19 N 4 O 9 P 1 DiffMono: 454.088965 Formula: C 23 H 26 N 7 O 10 P 1 MassAvg: 591.47 MassMono: 591.147877 Origin: H Source: hypothetical TermSpec: none Unimod: Unimod:409 (S)-2-amino-3-(3-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid 3'-(8alpha-FMN)-L-histidine 8alpha-(N(delta)-histidyl)FMN 8alpha-(N3'-histidyl)FMN N(pi)-(8alpha-FMN)-histidine Npros8aFMNHis pros-(8alpha-FMN)-histidine FMNH flavin mononucleotide A protein modification that effectively converts an L-arginine residue to N2-acetyl-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0180 (S)-2-acetamido-5-carbamimidamidopentanoic acid 2-acetamido-5-guanidinopentanoic acid 2-acetylamino-5-guanidinopentanoic acid AcArg MOD_RES N2-acetylarginine N(alpha)-acetylarginine N2-acetyl-L-arginine N2-acetylated L-arginine acetylarginine alpha-acetylamino-delta-guanidinovaleric acid PSI-MOD MOD:00359 N2-acetyl-L-arginine MOD:00359 A protein modification that effectively converts an L-arginine residue to N2-acetyl-L-arginine. PubMed:12883043 PubMed:1894641 RESID:AA0354 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 8 H 15 N 4 O 2 MassAvg: 199.23 MassMono: 199.119501 Origin: R Source: natural TermSpec: N-term (S)-2-acetamido-5-carbamimidamidopentanoic acid 2-acetamido-5-guanidinopentanoic acid 2-acetylamino-5-guanidinopentanoic acid AcArg MOD_RES N2-acetylarginine N(alpha)-acetylarginine N2-acetyl-L-arginine N2-acetylated L-arginine acetylarginine alpha-acetylamino-delta-guanidinovaleric acid A protein modification that effectively converts an L-cysteine residue to L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide [8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with cytosine)methyl-6-oxo-3,4-dimercapto-pteridino[6,7-5,6]pyranoato-S3,S4]-cysteinyl-S-copper-mu-sulfido-molybdenum hydroxide oxide cysteinyl copper mu-sulfido Mo-pterin cytosine dinucleotide PSI-MOD CuSMo copper sulfido molybdopterin cytosine dinuncleotide MOD:00360 L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide MOD:00360 A protein modification that effectively converts an L-cysteine residue to L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide. PubMed:12475995 RESID:AA0355 Unimod:444#C DiffAvg: 922.07 DiffFormula: C 19 Cu 1 H 24 Mo 1 N 8 O 15 P 2 S 3 DiffMono: 922.834854 Formula: C 22 Cu 1 H 29 Mo 1 N 9 O 16 P 2 S 4 MassAvg: 1025.20 MassMono: 1025.844039 Origin: C Source: natural TermSpec: none Unimod: Unimod:444 L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide [8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with cytosine)methyl-6-oxo-3,4-dimercapto-pteridino[6,7-5,6]pyranoato-S3,S4]-cysteinyl-S-copper-mu-sulfido-molybdenum hydroxide oxide cysteinyl copper mu-sulfido Mo-pterin cytosine dinucleotide CuSMo copper sulfido molybdopterin cytosine dinuncleotide A protein modification that effectively converts three L-cysteine residues, an S-adenosylmethionine and a four-iron four-sulfur cluster to tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (4Fe-4S-S-AdoMet) tetra-mu3-sulfido(S-adenosylmethion-N,O-diyliron)tris(S-cysteinyliron) tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide PSI-MOD MOD:00361 Cross-link 3. tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide MOD:00361 A protein modification that effectively converts three L-cysteine residues, an S-adenosylmethionine and a four-iron four-sulfur cluster to tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide. PubMed:11222759 PubMed:14704425 RESID:AA0356 DiffAvg: 747.03 DiffFormula: C 15 Fe 4 H 19 N 6 O 5 S 5 DiffMono: 746.742346 FormalCharge: 1- Formula: C 24 Fe 4 H 34 N 9 O 8 S 8 MassAvg: 1056.45 MassMono: 1055.769901 Origin: C, C, C Source: natural TermSpec: none METAL Iron-sulfur (4Fe-4S-S-AdoMet) tetra-mu3-sulfido(S-adenosylmethion-N,O-diyliron)tris(S-cysteinyliron) tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide A protein modification that effectively converts three L-cysteine residues, an L-arginine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-arginyl diiron disulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (2Fe-2S) di-mu-sulfido(N(eta1)-arginyl-S-cysteinyliron)(bis-S-cysteinyliron) tris-L-cysteinyl L-arginyl diiron disulfide PSI-MOD MOD:00362 Cross-link 4. tris-L-cysteinyl L-arginyl diiron disulfide MOD:00362 A protein modification that effectively converts three L-cysteine residues, an L-arginine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-arginyl diiron disulfide. PubMed:14704425 RESID:AA0357 DiffAvg: 172.79 DiffFormula: C 0 Fe 2 H -3 N 0 O 0 S 2 DiffMono: 172.791639 FormalCharge: 2- Formula: C 15 Fe 2 H 24 N 7 O 4 S 5 MassAvg: 638.39 MassMono: 637.920304 Origin: C, C, C, R Source: natural TermSpec: none METAL Iron-sulfur (2Fe-2S) di-mu-sulfido(N(eta1)-arginyl-S-cysteinyliron)(bis-S-cysteinyliron) tris-L-cysteinyl L-arginyl diiron disulfide A protein modification that effectively cross-links an L-cysteine residue and an L-selenocysteine residues to form L-cysteinyl-L-selenocystine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0109 (R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid CROSSLNK Cysteinyl-selenocysteine (Cys-Sec) CROSSLNK Cysteinyl-selenocysteine (Sec-Cys) L-cysteinyl-L-selenocysteine PSI-MOD MOD:00363 Cross-link 2. L-cysteinyl-L-selenocysteine (Cys-Sec) MOD:00363 A protein modification that effectively cross-links an L-cysteine residue and an L-selenocysteine residues to form L-cysteinyl-L-selenocystine. PubMed:12911312 RESID:AA0358#SEC DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 Se 0 DiffMono: -2.015650 Formula: C 6 H 8 N 2 O 2 S 1 Se 1 MassAvg: 251.17 MassMono: 251.947170 Origin: C, U Source: natural TermSpec: none (R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid CROSSLNK Cysteinyl-selenocysteine (Cys-Sec) CROSSLNK Cysteinyl-selenocysteine (Sec-Cys) L-cysteinyl-L-selenocysteine A protein modification that effectively converts an L-lysine residue to 5-hydroxy-N6,N6,N6-trimethyl-L-lysine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0186 (2R,5Xi)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentan-1-aminium (2Xi,5S)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentanaminium (2Xi,5S)-5-azanyl-5-carboxy-2-hydroxy-N,N,N-trimethylpentanazanium 5-hydroxy-N(zeta)-trimethyllysine 5-hydroxy-N6,N6,N6-trimethyl-L-lysine 5-hydroxy-N6,N6,N6-trimethyllysin-N6-ium 5-hydroxy-N6,N6,N6-trimethyllysine cation 5-hydroxylated N6,N6,N6-trimethylated L-lysine 5HyN6Me3Lys MOD_RES N6,N6,N6-trimethyl-5-hydroxylysine alpha-amino-epsilon-dimethylamino-delta-hydroxycaproic acid delta-hydroxy-epsilon-N,N,N-trimethyllysine lysine derivative Lys(z) PSI-MOD 5-hydroxy-N6,N6,N6-trimethyl Hydroxytrimethyl MOD:00364 Incidental to RESID:AA0278; secondary to RESID:AA0028; secondary to RESID:AA0074. 5-hydroxy-N6,N6,N6-trimethyl-L-lysine MOD:00364 A protein modification that effectively converts an L-lysine residue to 5-hydroxy-N6,N6,N6-trimethyl-L-lysine. PubMed:11349130 PubMed:14661085 RESID:AA0359 Unimod:445#K DiffAvg: 59.09 DiffFormula: C 3 H 7 N 0 O 1 DiffMono: 59.049141 FormalCharge: 1+ Formula: C 9 H 19 N 2 O 2 MassAvg: 187.26 MassMono: 187.144104 Origin: K Source: natural TermSpec: none Unimod: Unimod:445 (2R,5Xi)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentan-1-aminium (2Xi,5S)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentanaminium (2Xi,5S)-5-azanyl-5-carboxy-2-hydroxy-N,N,N-trimethylpentanazanium 5-hydroxy-N(zeta)-trimethyllysine 5-hydroxy-N6,N6,N6-trimethyl-L-lysine 5-hydroxy-N6,N6,N6-trimethyllysin-N6-ium 5-hydroxy-N6,N6,N6-trimethyllysine cation 5-hydroxylated N6,N6,N6-trimethylated L-lysine 5HyN6Me3Lys MOD_RES N6,N6,N6-trimethyl-5-hydroxylysine alpha-amino-epsilon-dimethylamino-delta-hydroxycaproic acid delta-hydroxy-epsilon-N,N,N-trimethyllysine lysine derivative Lys(z) 5-hydroxy-N6,N6,N6-trimethyl Hydroxytrimethyl A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue by an isopeptide bond to form N-(L-isoglutamyl)-glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0157 (S)-2-amino-5-(carboxymethyl)amino-5-oxopentanoic acid 2-amino-N5-(carboxymethyl)-pentanediamic acid CROSSLNK Isoglutamyl glycine isopeptide (Gly-Glu) N-(L-isoglutamyl)-glycine N-gamma-glutamylglycine isoglutamyl glycine PSI-MOD MOD:00365 Cross-link 2. N-(L-isoglutamyl)-glycine MOD:00365 A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue by an isopeptide bond to form N-(L-isoglutamyl)-glycine. PubMed:14531691 RESID:AA0360 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 7 H 9 N 2 O 3 MassAvg: 169.16 MassMono: 169.061317 Origin: E, G Source: natural TermSpec: N-term (S)-2-amino-5-(carboxymethyl)amino-5-oxopentanoic acid 2-amino-N5-(carboxymethyl)-pentanediamic acid CROSSLNK Isoglutamyl glycine isopeptide (Gly-Glu) N-(L-isoglutamyl)-glycine N-gamma-glutamylglycine isoglutamyl glycine A protein modification that effectively converts an L-serine residue to O-sulfo-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0284 (2S)-2-amino-3-(sulfooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-sulfate MOD_RES Sulfoserine O-sulfo-L-serine O3-sulfonoserine O3-sulfoserine serine sulfate ester PSI-MOD O-Sulfonation Sulfo MOD:00366 O-sulfo-L-serine MOD:00366 A protein modification that effectively converts an L-serine residue to O-sulfo-L-serine. PubMed:14752058 RESID:AA0361 Unimod:40#S DiffAvg: 80.06 DiffFormula: C 0 H 0 N 0 O 3 S 1 DiffMono: 79.956815 Formula: C 3 H 5 N 1 O 5 S 1 MassAvg: 167.13 MassMono: 166.988843 Origin: S Source: natural TermSpec: none Unimod: Unimod:40 (2S)-2-amino-3-(sulfooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-sulfate MOD_RES Sulfoserine O-sulfo-L-serine O3-sulfonoserine O3-sulfoserine serine sulfate ester O-Sulfonation Sulfo A protein modification that effectively converts an L-threonine residue to O-sulfo-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0285 (2S,3R)-2-amino-3-(sulfooxy)butanoic acid 2-amino-3-hydroxybutanoic acid 3-sulfate MOD_RES Sulfothreonine O-sulfo-L-threonine O3-sulfonothreonine O3-sulfothreonine threonine sulfate ester PSI-MOD O-Sulfonation Sulfo MOD:00367 O-sulfo-L-threonine MOD:00367 A protein modification that effectively converts an L-threonine residue to O-sulfo-L-threonine. PubMed:14752058 RESID:AA0362 Unimod:40#T DiffAvg: 80.06 DiffFormula: C 0 H 0 N 0 O 3 S 1 DiffMono: 79.956815 Formula: C 4 H 7 N 1 O 5 S 1 MassAvg: 181.16 MassMono: 181.004493 Origin: T Source: natural TermSpec: none Unimod: Unimod:40 (2S,3R)-2-amino-3-(sulfooxy)butanoic acid 2-amino-3-hydroxybutanoic acid 3-sulfate MOD_RES Sulfothreonine O-sulfo-L-threonine O3-sulfonothreonine O3-sulfothreonine threonine sulfate ester O-Sulfonation Sulfo A protein modification that effectively converts an L-methionine residue to N-carboxy-L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (S)-2-carboxyamino-4-(methylsulfanyl)butanoic acid 2-carbamic-4-(methylsulfanyl)butanoic acid 2-carbamic-4-(methylthio)butanoic acid N-carboxy-L-methionine N-carboxymethionine PSI-MOD Carboxy Carboxylation MOD:00368 At least three protein crystallographic structures have been reported with this modification. However, no chemical evidence for this modification is provided, there were no reports of this modification before these crystallographic reports, and there is no metabolic explanation for the conversion of a formyl group to a carboxy group. There is confusion in its description, and misnaming is common. This modification is probably a misidentification of N-(dihydroxymethyl)methionine, the hydrated form of N-formylmethionine. See MOD:01446 [JSG]. N-carboxy-L-methionine MOD:00368 A protein modification that effectively converts an L-methionine residue to N-carboxy-L-methionine. PubMed:10368287 PubMed:11120890 PubMed:12595263 PubMed:8312270 RESID:AA0363 Unimod:299#M DiffAvg: 44.01 DiffFormula: C 1 H 0 N 0 O 2 S 0 DiffMono: 43.989829 Formula: C 6 H 10 N 1 O 3 S 1 MassAvg: 176.21 MassMono: 176.038139 Origin: M Source: hypothetical TermSpec: N-term Unimod: Unimod:299 (S)-2-carboxyamino-4-(methylsulfanyl)butanoic acid 2-carbamic-4-(methylsulfanyl)butanoic acid 2-carbamic-4-(methylthio)butanoic acid N-carboxy-L-methionine N-carboxymethionine Carboxy Carboxylation A protein modification that effectively converts an L-serine residue to O-acetyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0232 (2S)-3-(acetyloxy)-2-aminopropanoic acid MOD_RES O-acetylserine O-acetyl-L-serine O-acetylated L-serine O-acetylserine OAcSer serine acetate ester PSI-MOD Acetyl Acetylation MOD:00369 incidental to RESID:AA0051 O-acetyl-L-serine MOD:00369 A protein modification that effectively converts an L-serine residue to O-acetyl-L-serine. ChEBI:17981 PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 PubMed:16731519 PubMed:489587 PubMed:7309355 RESID:AA0364 Unimod:1#S DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: S Source: natural TermSpec: none Unimod: Unimod:1 (2S)-3-(acetyloxy)-2-aminopropanoic acid MOD_RES O-acetylserine O-acetyl-L-serine O-acetylated L-serine O-acetylserine OAcSer serine acetate ester Acetyl Acetylation A protein modification that effectively converts an L-tyrosine residue to (E)-2,3-didehydrotyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0001 (2E)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid (E)-2,3-didehydrogenated tyrosine (E)-2,3-didehydrotyrosine E-dHTyr MOD_RES (E)-2,3-didehydrotyrosine amino-(para-hydroxybenzylidenyl)acetic acid blue non-fluorescent pocilloporin chromophore para-hydroxybenzylidene-imidazolidinone chromophore trans-dehydrotyrosine PSI-MOD 2-amino-3-oxo-butanoic_acid Didehydro MOD:00370 incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381 (E)-2,3-didehydrotyrosine MOD:00370 A protein modification that effectively converts an L-tyrosine residue to (E)-2,3-didehydrotyrosine. PubMed:12623015 RESID:AA0365 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 9 H 7 N 1 O 2 MassAvg: 161.16 MassMono: 161.047678 Origin: Y Source: natural TermSpec: none (2E)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid (E)-2,3-didehydrogenated tyrosine (E)-2,3-didehydrotyrosine E-dHTyr MOD_RES (E)-2,3-didehydrotyrosine amino-(para-hydroxybenzylidenyl)acetic acid blue non-fluorescent pocilloporin chromophore para-hydroxybenzylidene-imidazolidinone chromophore trans-dehydrotyrosine 2-amino-3-oxo-butanoic_acid Didehydro A protein modification that effectively converts two L-aspartic acid residues, three L-glutamic acid residues, an L-histidine residue, and a one-calcium, four-iron, four-oxygen cluster to bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4Mn-Ca-4O cluster bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide mu3-1:2:3kappaO-oxido-mu3-1:3:4kappaO-oxido-mu3-2:3:4kappaO-oxido-mu4-1:2:4:5kappaO-oxido-N1'-histidino-O5-glutamato 2-manganese-O5,O5-glutamato 3-manganese-O4-aspartato 4-manganese-O4-aspartato-O5-glutamato 5-manganese photosystem II catalytic cluster PSI-MOD MOD:00371 Cross-link 6. bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide MOD:00371 A protein modification that effectively converts two L-aspartic acid residues, three L-glutamic acid residues, an L-histidine residue, and a one-calcium, four-iron, four-oxygen cluster to bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide. PubMed:14764885 RESID:AA0366 DiffAvg: 317.78 DiffFormula: C 0 Ca 1 H -6 Mn 4 N 0 O 4 DiffMono: 317.647480 Formula: C 29 Ca 1 H 32 Mn 4 N 8 O 20 MassAvg: 1072.44 MassMono: 1071.888057 Origin: D, D, E, E, E, H Source: hypothetical TermSpec: none 4Mn-Ca-4O cluster bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide mu3-1:2:3kappaO-oxido-mu3-1:3:4kappaO-oxido-mu3-2:3:4kappaO-oxido-mu4-1:2:4:5kappaO-oxido-N1'-histidino-O5-glutamato 2-manganese-O5,O5-glutamato 3-manganese-O4-aspartato 4-manganese-O4-aspartato-O5-glutamato 5-manganese photosystem II catalytic cluster A protein modification that effectively cross-links two L-tyrosine residues with a carbon-carbon bond to form 3'-(3'-L-tyrosinyl)-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,2'S)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)bis(2-aminopropanoic acid) 3'-(L-tyros-3'-yl)-L-tyrosine 3,3'-BiTyr (Crosslink) 6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-bis(2-aminopropanoic acid) alpha,alpha'-diamino-6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-dipropanoic acid bityrosine o,o-dityrosine PSI-MOD MOD:00372 Cross-link 2; From DeltaMass: Average Mass: -2. 3'-(3'-L-tyrosinyl)-L-tyrosine MOD:00372 A protein modification that effectively cross-links two L-tyrosine residues with a carbon-carbon bond to form 3'-(3'-L-tyrosinyl)-L-tyrosine. DeltaMass:0 PubMed:14249161 PubMed:637884 PubMed:8702710 PubMed:8937563 RESID:AA0367 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 18 H 16 N 2 O 4 MassAvg: 324.34 MassMono: 324.111007 Origin: Y, Y Source: natural TermSpec: none (2S,2'S)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)bis(2-aminopropanoic acid) 3'-(L-tyros-3'-yl)-L-tyrosine 3,3'-BiTyr (Crosslink) 6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-bis(2-aminopropanoic acid) alpha,alpha'-diamino-6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-dipropanoic acid bityrosine o,o-dityrosine A protein modification that effectively cross-links L-tyrosine residues with an ether bond to form 3'-(O4'-L-tyrosinyl)-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0155 (2S)-2-amino-3-[3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-4-hydroxyphenyl]propanoic acid 2-amino-3-[4-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenoxy)phenyl]propanoic acid 3'-(L-tyros-O4'-yl)-L-tyrosine CROSSLNK Isodityrosine (Tyr-Tyr) IsodiTyr (Crosslink) O-(5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl)-L-tyrosine isodityrosine PSI-MOD MOD:00373 Cross-link 2; secondary to RESID:AA0146; From DeltaMass: Average Mass: -2. 3'-(O4'-L-tyrosinyl)-L-tyrosine MOD:00373 A protein modification that effectively cross-links L-tyrosine residues with an ether bond to form 3'-(O4'-L-tyrosinyl)-L-tyrosine. DeltaMass:0 PubMed:12719529 PubMed:7115340 PubMed:8702710 RESID:AA0368 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 18 H 16 N 2 O 4 MassAvg: 324.34 MassMono: 324.111007 Origin: Y, Y Source: natural TermSpec: none (2S)-2-amino-3-[3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-4-hydroxyphenyl]propanoic acid 2-amino-3-[4-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenoxy)phenyl]propanoic acid 3'-(L-tyros-O4'-yl)-L-tyrosine CROSSLNK Isodityrosine (Tyr-Tyr) IsodiTyr (Crosslink) O-(5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl)-L-tyrosine isodityrosine A protein modification that effectively converts an L-arginine residue to 3,4-dihydroxy-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0022 (2S,3Xi,4Xi)-2-amino-5-carbamimidamido-3,4-dihydroxypentanoic acid 2-amino-5-guanidino-3,4-dihydroxypentanoic acid 3,4-dihydroxy-L-arginine 3,4-dihydroxylated L-arginine 34Hy2Arg MOD_RES 3,4-dihydroxyarginine beta,gamma-dihydroxyarginine PSI-MOD Dioxidation dihydroxy MOD:00374 3,4-dihydroxy-L-arginine MOD:00374 A protein modification that effectively converts an L-arginine residue to 3,4-dihydroxy-L-arginine. ChEBI:141829 PubMed:10978343 PubMed:12686488 RESID:AA0369 Unimod:425#R DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 6 H 12 N 4 O 3 MassAvg: 188.19 MassMono: 188.090940 Origin: R Source: natural TermSpec: none Unimod: Unimod:425 (2S,3Xi,4Xi)-2-amino-5-carbamimidamido-3,4-dihydroxypentanoic acid 2-amino-5-guanidino-3,4-dihydroxypentanoic acid 3,4-dihydroxy-L-arginine 3,4-dihydroxylated L-arginine 34Hy2Arg MOD_RES 3,4-dihydroxyarginine beta,gamma-dihydroxyarginine Dioxidation dihydroxy A protein modification that effectively converts an L-lysine residue to 4,5-dihydroxy-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0036 (2S,4Xi,5Xi)-2,6-diamino-4,5-dihydroxyhexanoic acid 4,5-dihydroxy-L-lysine 4,5-dihydroxylated L-lysine 45Hy2Lys MOD_RES 4,5-dihydroxylysine alpha,epsilon-diamino-delta,gamma-dihydroxycaproic acid delta,gamma-dihydroxylysine PSI-MOD Dioxidation dihydroxy MOD:00375 4,5-dihydroxy-L-lysine MOD:00375 A protein modification that effectively converts an L-lysine residue to 4,5-dihydroxy-L-lysine. PubMed:10978343 PubMed:12686488 RESID:AA0370 Unimod:425#K DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 6 H 12 N 2 O 3 MassAvg: 160.17 MassMono: 160.084792 Origin: K Source: natural TermSpec: none Unimod: Unimod:425 (2S,4Xi,5Xi)-2,6-diamino-4,5-dihydroxyhexanoic acid 4,5-dihydroxy-L-lysine 4,5-dihydroxylated L-lysine 45Hy2Lys MOD_RES 4,5-dihydroxylysine alpha,epsilon-diamino-delta,gamma-dihydroxycaproic acid delta,gamma-dihydroxylysine Dioxidation dihydroxy A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form 1'-(phospho-5'-adenosine)-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-3-[1-(5'-adenosine phosphono)imidazol-4-yl]propanoic acid 1'-(phospho-5'-adenosine)-L-histidine ACT_SITE Tele-AMP-histidine intermediate L-histidine 5'-adenosine phosphoramidester L-histidine monoanhydride with 5'-adenylic acid N(tau)-5'-adenylic-L-histidine N1'-adenylylated histidine tele-5'-adenylic-L-histidine PSI-MOD AMP binding site Phosphoadenosine MOD:00376 1'-(phospho-5'-adenosine)-L-histidine MOD:00376 A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form 1'-(phospho-5'-adenosine)-L-histidine. PubMed:15182206 PubMed:9323207 RESID:AA0371 Unimod:405#H DiffAvg: 329.21 DiffFormula: C 10 H 12 N 5 O 6 P 1 DiffMono: 329.052520 Formula: C 16 H 19 N 8 O 7 P 1 MassAvg: 466.35 MassMono: 466.111432 Origin: H Source: natural TermSpec: none Unimod: Unimod:405 (2S)-2-amino-3-[1-(5'-adenosine phosphono)imidazol-4-yl]propanoic acid 1'-(phospho-5'-adenosine)-L-histidine ACT_SITE Tele-AMP-histidine intermediate L-histidine 5'-adenosine phosphoramidester L-histidine monoanhydride with 5'-adenylic acid N(tau)-5'-adenylic-L-histidine N1'-adenylylated histidine tele-5'-adenylic-L-histidine AMP binding site Phosphoadenosine A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphouridine through a phosphoramide ester bond to form 1'-(phospho-5'-uridine)-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0500 (S)-2-amino-3-[1-(5'-uridine phosphono)imidazol-4-yl]propanoic acid 1'-(phospho-5'-uridine)-L-histidine ACT_SITE Tele-UMP-histidine intermediate L-histidine 5'-uridine phosphoramidester L-histidine monoanhydride with 5'-uridylic acid MOD_RES O-UMP-histidine N(tau)-5'-uridylic-L-histidine N1'-uridylylated histidine tele-5'-uridylic-L-histidine PSI-MOD PhosphoUridine uridine phosphodiester MOD:00377 1'-(phospho-5'-uridine)-L-histidine MOD:00377 A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphouridine through a phosphoramide ester bond to form 1'-(phospho-5'-uridine)-L-histidine. PubMed:11467524 PubMed:321007 PubMed:380639 PubMed:8794735 RESID:AA0372 Unimod:417#H DiffAvg: 306.17 DiffFormula: C 9 H 11 N 2 O 8 P 1 DiffMono: 306.025302 Formula: C 15 H 18 N 5 O 9 P 1 MassAvg: 443.31 MassMono: 443.084214 Origin: H Source: natural TermSpec: none Unimod: Unimod:417 (S)-2-amino-3-[1-(5'-uridine phosphono)imidazol-4-yl]propanoic acid 1'-(phospho-5'-uridine)-L-histidine ACT_SITE Tele-UMP-histidine intermediate L-histidine 5'-uridine phosphoramidester L-histidine monoanhydride with 5'-uridylic acid MOD_RES O-UMP-histidine N(tau)-5'-uridylic-L-histidine N1'-uridylylated histidine tele-5'-uridylic-L-histidine PhosphoUridine uridine phosphodiester A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl semialdehyde. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0064 (S)-2-amino-4-oxobutanoic acid L-aminosuccinaldehydic acid L-aminosuccinic acid semialdehyde L-aspartate-beta-semialdehyde L-aspartic beta-semialdehyde L-aspartyl aldehyde L-beta-formylalanine MOD_RES Aspartyl aldehyde aspartyl 4-semialdehyde aspartyl aldehyde PSI-MOD Deoxy reduction MOD:00378 L-aspartyl semialdehyde MOD:00378 A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl semialdehyde. PubMed:1093385 PubMed:14235557 PubMed:15237995 RESID:AA0373 Unimod:447#D DiffAvg: -16.00 DiffFormula: C 0 H 0 N 0 O -1 DiffMono: -15.994915 Formula: C 4 H 5 N 1 O 2 MassAvg: 99.09 MassMono: 99.032028 Origin: D Source: natural TermSpec: none Unimod: Unimod:447 (S)-2-amino-4-oxobutanoic acid L-aminosuccinaldehydic acid L-aminosuccinic acid semialdehyde L-aspartate-beta-semialdehyde L-aspartic beta-semialdehyde L-aspartyl aldehyde L-beta-formylalanine MOD_RES Aspartyl aldehyde aspartyl 4-semialdehyde aspartyl aldehyde Deoxy reduction A protein modification that effectively converts an L-serine residue to L-serine microcin E492 siderophore ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0276 L-serine microcin E492 siderophore ester MOD_RES Serine microcin E492 siderophore ester N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine PSI-MOD Microcin microcin E492 siderophore ester from serine MOD:00379 Unimod origin corrected [JSG]. L-serine microcin E492 siderophore ester MOD:00379 A protein modification that effectively converts an L-serine residue to L-serine microcin E492 siderophore ester. PubMed:15102848 RESID:AA0374 Unimod:448#C-term DiffAvg: 831.69 DiffFormula: C 36 H 37 N 3 O 20 DiffMono: 831.197041 Formula: C 39 H 43 N 4 O 23 MassAvg: 935.78 MassMono: 935.231809 Origin: S Source: natural TermSpec: C-term Unimod: Unimod:448 L-serine microcin E492 siderophore ester MOD_RES Serine microcin E492 siderophore ester N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine Microcin microcin E492 siderophore ester from serine A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-aspartyl-molybdenum nitrate reductase A aspartyl Mo-bisMGD cofactor phosphoric acid 4-(2-amino-4-oxo-3,4,5,6,-tetrahydro-pteridin-6-yl)-2-hydroxy-3,4-dimercapto-but-3-en-yl ester guanylate ester PSI-MOD MolybdopterinGD molybdenum bis(molybdopterin guanine dinucleotide) MOD:00380 L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) MOD:00380 A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide). PubMed:12910261 PubMed:14725769 RESID:AA0375 Unimod:424#D DiffAvg: 1572.02 DiffFormula: C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 DiffMono: 1572.985775 Formula: C 44 H 52 Mo 1 N 21 O 29 P 4 S 4 MassAvg: 1687.10 MassMono: 1688.012718 Origin: D Source: natural TermSpec: none Unimod: Unimod:424 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-aspartyl-molybdenum nitrate reductase A aspartyl Mo-bisMGD cofactor phosphoric acid 4-(2-amino-4-oxo-3,4,5,6,-tetrahydro-pteridin-6-yl)-2-hydroxy-3,4-dimercapto-but-3-en-yl ester guanylate ester MolybdopterinGD molybdenum bis(molybdopterin guanine dinucleotide) A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00381 L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Sec) MOD:00381 A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide). PubMed:11372198 PubMed:12220497 RESID:AA0376#SEC DiffAvg: 1691.97 DiffFormula: C 40 H 47 N 20 O 26 P 4 S 5 Se 0 W 1 DiffMono: 1691.003369 Formula: C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1 MassAvg: 1842.02 MassMono: 1841.957004 Origin: U Source: natural TermSpec: none A protein modification that effectively crosslinks an L-methionyl-L-tyrosine dipeptide to form 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-(2-methylsulfanyl)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-amino-3,6-didehydropyrazin-2-ol 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one GFP-like chromoprotein asFP595 chromophore L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine PSI-MOD MOD:00382 carboxamidine; cross-link 1. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one MOD:00382 A protein modification that effectively crosslinks an L-methionyl-L-tyrosine dipeptide to form 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one. PubMed:10852900 PubMed:11259412 PubMed:15491166 RESID:AA0377 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 14 H 15 N 2 O 2 S 1 MassAvg: 275.35 MassMono: 275.085424 Origin: M, Y Source: hypothetical TermSpec: N-term 3-(2-methylsulfanyl)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-amino-3,6-didehydropyrazin-2-ol 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one GFP-like chromoprotein asFP595 chromophore L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue to form 2-imino-glutamic acid 5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0014 2,N-didehydroglutamyl-5-imidazolinone glycine 2-(3-carboxy-1-iminopropyl)-1-carboxymethyl-1-imidazolin-5-one 2-imino-glutamic acid 5-imidazolinone glycine 2-imino-glutamyl-5-imidazolinone glycine 4-[1-(carboxymethyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-iminobutanoic acid CROSSLNK 2-iminomethyl-5-imidazolinone (Glu-Gly) [2-(3-carboxy-1-iminopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid para-hydroxybenzylidene-imidazolidinone chromophore PSI-MOD MOD:00383 Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. 2-imino-glutamic acid 5-imidazolinone glycine MOD:00383 A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue to form 2-imino-glutamic acid 5-imidazolinone glycine. PubMed:11682051 RESID:AA0378 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 DiffMono: -20.026215 Formula: C 7 H 6 N 2 O 3 MassAvg: 166.14 MassMono: 166.037842 Origin: E, G Source: hypothetical TermSpec: none 2,N-didehydroglutamyl-5-imidazolinone glycine 2-(3-carboxy-1-iminopropyl)-1-carboxymethyl-1-imidazolin-5-one 2-imino-glutamic acid 5-imidazolinone glycine 2-imino-glutamyl-5-imidazolinone glycine 4-[1-(carboxymethyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-iminobutanoic acid CROSSLNK 2-iminomethyl-5-imidazolinone (Glu-Gly) [2-(3-carboxy-1-iminopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid para-hydroxybenzylidene-imidazolidinone chromophore A protein modification that effectively crosslinks an L-methionine residue and a glycine residue to form 2-imino-methionine 5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0015 (2-[1-imino-3-(methylsulfanyl)propyl]-5-oxo-4,5-dihydro-imidazol-1-yl)acetic acid (2-[3-(methylsulfanyl)propanimidoyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2,N-didehydromethionyl-5-imidazolinone glycine 2-[1-imino-3-(methylsulfanyl)propyl]-1-carboxymethyl-1-imidazolin-5-one 2-imino-methionine 5-imidazolinone glycine 2-imino-methionyl-5-imidazolinone glycine CROSSLNK 2-iminomethyl-5-imidazolinone (Met-Gly) GFP-like chromoprotein asFP595 chromophore para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein eqFP611 chromophore PSI-MOD MOD:00384 Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365. 2-imino-methionine 5-imidazolinone glycine MOD:00384 A protein modification that effectively crosslinks an L-methionine residue and a glycine residue to form 2-imino-methionine 5-imidazolinone glycine. PubMed:10852900 PubMed:12185250 PubMed:12909624 PubMed:15542608 RESID:AA0379 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 7 H 8 N 2 O 1 S 1 MassAvg: 168.21 MassMono: 168.035734 Origin: G, M Source: natural TermSpec: none (2-[1-imino-3-(methylsulfanyl)propyl]-5-oxo-4,5-dihydro-imidazol-1-yl)acetic acid (2-[3-(methylsulfanyl)propanimidoyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2,N-didehydromethionyl-5-imidazolinone glycine 2-[1-imino-3-(methylsulfanyl)propyl]-1-carboxymethyl-1-imidazolin-5-one 2-imino-methionine 5-imidazolinone glycine 2-imino-methionyl-5-imidazolinone glycine CROSSLNK 2-iminomethyl-5-imidazolinone (Met-Gly) GFP-like chromoprotein asFP595 chromophore para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein eqFP611 chromophore A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue to form L-asparagine 5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0046 (2-[(1S)-1,3-diamino-3-oxopropyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[(S)-1,3-diamino-3-oxopropyl]-1-carboxymethyl-1-imidazolin-5-one CROSSLNK 5-imidazolinone (Asn-Gly) L-asparagine 5-imidazolinone glycine Zoanthus sp. fluorescent protein FP506 chromophore [2-(1,3-diamino-3-oxopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid asparaginyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore PSI-MOD MOD:00385 Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. L-asparagine 5-imidazolinone glycine MOD:00385 A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue to form L-asparagine 5-imidazolinone glycine. PubMed:10504696 RESID:AA0380 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 6 H 7 N 3 O 2 MassAvg: 153.14 MassMono: 153.053826 Origin: G, N Source: hypothetical TermSpec: none (2-[(1S)-1,3-diamino-3-oxopropyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[(S)-1,3-diamino-3-oxopropyl]-1-carboxymethyl-1-imidazolin-5-one CROSSLNK 5-imidazolinone (Asn-Gly) L-asparagine 5-imidazolinone glycine Zoanthus sp. fluorescent protein FP506 chromophore [2-(1,3-diamino-3-oxopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid asparaginyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form L-lysine 5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0048 (2-[(1S)-1,5-diaminopentyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[(S)-1,5-diaminopentanyl]-1-carboxymethyl-1-imidazolin-5-one Anemonia majano fluorescent protein FP486 chromophore CROSSLNK 5-imidazolinone (Lys-Gly) L-lysine 5-imidazolinone glycine [2-(1,5-diaminopentanyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid lysyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore PSI-MOD MOD:00386 Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. L-lysine 5-imidazolinone glycine MOD:00386 A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form L-lysine 5-imidazolinone glycine. PubMed:10504696 RESID:AA0381 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 8 H 13 N 3 O 1 MassAvg: 167.21 MassMono: 167.105862 Origin: G, K Source: hypothetical TermSpec: none (2-[(1S)-1,5-diaminopentyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2-[(S)-1,5-diaminopentanyl]-1-carboxymethyl-1-imidazolin-5-one Anemonia majano fluorescent protein FP486 chromophore CROSSLNK 5-imidazolinone (Lys-Gly) L-lysine 5-imidazolinone glycine [2-(1,5-diaminopentanyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid lysyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form 2-tetrahydropyridinyl-5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0018 2-(3,4,5,6-tetrahydropyridin-2-yl)-1-carboxymethyl-1-imidazolin-5-one 2-(tetrahydropyrid-2-yl)-5-imidazolinone glycine 2-tetrahydropyridinyl-5-imidazolinone glycine CROSSLNK 2-tetrahydro-2-pyridyl-5-imidazolinone (Lys-Gly) Zoanthus sp. fluorescent protein zFP538 chromophore [5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid para-hydroxybenzylidene-imidazolidinone chromophore PSI-MOD MOD:00387 Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365. 2-tetrahydropyridinyl-5-imidazolinone glycine MOD:00387 A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form 2-tetrahydropyridinyl-5-imidazolinone glycine. PubMed:10504696 PubMed:15628861 RESID:AA0382 DiffAvg: -37.06 DiffFormula: C 0 H -7 N -1 O -1 DiffMono: -37.052764 Formula: C 8 H 9 N 2 O 1 MassAvg: 149.17 MassMono: 149.071488 Origin: G, K Source: natural TermSpec: N-term 2-(3,4,5,6-tetrahydropyridin-2-yl)-1-carboxymethyl-1-imidazolin-5-one 2-(tetrahydropyrid-2-yl)-5-imidazolinone glycine 2-tetrahydropyridinyl-5-imidazolinone glycine CROSSLNK 2-tetrahydro-2-pyridyl-5-imidazolinone (Lys-Gly) Zoanthus sp. fluorescent protein zFP538 chromophore [5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid [5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid para-hydroxybenzylidene-imidazolidinone chromophore A protein modification that effectively attaches an L-alanine residue to murein peptidoglycan by a pentaglycine linker peptide. Origin: Source: TermSpec: uniprot.ptm:PTM-0245 (2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(alanyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine L-alanyl-pentaglycyl-murein peptidoglycan MOD_RES Pentaglycyl murein peptidoglycan amidated alanine PSI-MOD MOD:00388 L-alanyl-pentaglycyl-murein peptidoglycan MOD:00388 A protein modification that effectively attaches an L-alanine residue to murein peptidoglycan by a pentaglycine linker peptide. PubMed:8163519 RESID:AA0383 Origin: A Source: hypothetical TermSpec: C-term (2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(alanyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine L-alanyl-pentaglycyl-murein peptidoglycan MOD_RES Pentaglycyl murein peptidoglycan amidated alanine A protein modification that effectively converts an L-proline residue to N-formyl-L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-1-formylpyrrolidine-2-carboxylic acid 1-formyl-2-pyrrolidinecarboxylic acid 1-formylproline N-formyl-L-proline N-formylated L-proline NFoPro PSI-MOD MOD:00389 CAUTION - observations of this modification can be attributed to unintended artifactual production, or to spurious peptide MS identification. This modification is probably not a natural post-translational modification [JSG]. N-formyl-L-proline MOD:00389 A protein modification that effectively converts an L-proline residue to N-formyl-L-proline. PubMed:12051774 PubMed:5464655 RESID:AA0384 Unimod:122#N-term DiffAvg: 28.01 DiffFormula: C 1 H 0 N 0 O 1 DiffMono: 27.994915 Formula: C 6 H 8 N 1 O 2 MassAvg: 126.14 MassMono: 126.055504 Origin: P Source: hypothetical TermSpec: N-term Unimod: Unimod:122 (2S)-1-formylpyrrolidine-2-carboxylic acid 1-formyl-2-pyrrolidinecarboxylic acid 1-formylproline N-formyl-L-proline N-formylated L-proline NFoPro A protein modification that effectively converts an L-serine residue to O-decanoyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0234 (2S)-2-amino-3-(decanoyloxy)propanoic acid L-serine decanoate ester LIPID O-decanoyl serine O-decanoyl-L-serine O-decanoylated L-serine O3-decanoyl-L-serine ODecSer PSI-MOD Decanoyl lipid MOD:00390 O-decanoyl-L-serine MOD:00390 A protein modification that effectively converts an L-serine residue to O-decanoyl-L-serine. PubMed:12630926 RESID:AA0385 Unimod:449#S DiffAvg: 154.25 DiffFormula: C 10 H 18 N 0 O 1 DiffMono: 154.135765 Formula: C 13 H 23 N 1 O 3 MassAvg: 241.33 MassMono: 241.167794 Origin: S Source: natural TermSpec: none Unimod: Unimod:449 (2S)-2-amino-3-(decanoyloxy)propanoic acid L-serine decanoate ester LIPID O-decanoyl serine O-decanoyl-L-serine O-decanoylated L-serine O3-decanoyl-L-serine ODecSer Decanoyl lipid A protein modification that effectively converts an L-threonine residue to O-octanoyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0240 (2S)-2-amino-3-(octanoyloxy)butanoic acid L-threonine octanoate ester LIPID O-octanoyl threonine O-octanoyl-L-threonine O-octanoylated L-threonine O3-octanoyl-L-threonine OOctThr PSI-MOD Octanoyl octanoyl MOD:00391 O-octanoyl-L-threonine MOD:00391 A protein modification that effectively converts an L-threonine residue to O-octanoyl-L-threonine. PubMed:11546772 PubMed:12716131 RESID:AA0386 Unimod:426#T DiffAvg: 126.20 DiffFormula: C 8 H 14 N 0 O 1 DiffMono: 126.104465 Formula: C 12 H 21 N 1 O 3 MassAvg: 227.30 MassMono: 227.152144 Origin: T Source: natural TermSpec: none Unimod: Unimod:426 (2S)-2-amino-3-(octanoyloxy)butanoic acid L-threonine octanoate ester LIPID O-octanoyl threonine O-octanoyl-L-threonine O-octanoylated L-threonine O3-octanoyl-L-threonine OOctThr Octanoyl octanoyl A protein modification that effectively converts an L-threonine residue to O-decanoyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0235 (2S)-2-amino-3-(decanoyloxy)propanoic acid L-threonine decanoate ester LIPID O-decanoyl threonine O-decanoyl-L-threonine O-decanoylated L-threonine O3-decanoyl-L-threonine ODecThr PSI-MOD Decanoyl lipid MOD:00392 O-decanoyl-L-threonine MOD:00392 A protein modification that effectively converts an L-threonine residue to O-decanoyl-L-threonine. PubMed:11546772 RESID:AA0387 Unimod:449#T DiffAvg: 154.25 DiffFormula: C 10 H 18 N 0 O 1 DiffMono: 154.135765 Formula: C 14 H 25 N 1 O 3 MassAvg: 255.36 MassMono: 255.183444 Origin: T Source: natural TermSpec: none Unimod: Unimod:449 (2S)-2-amino-3-(decanoyloxy)propanoic acid L-threonine decanoate ester LIPID O-decanoyl threonine O-decanoyl-L-threonine O-decanoylated L-threonine O3-decanoyl-L-threonine ODecThr Decanoyl lipid A protein modification that effectively replaces a hydroxyl group hydrogen with a methyl group to produce either an ether from an alcohol or an ester from an acid. OMeRes PSI-MOD MOD:00393 O-methylated residue MOD:00393 A protein modification that effectively replaces a hydroxyl group hydrogen with a methyl group to produce either an ether from an alcohol or an ester from an acid. PubMed:18688235 OMeRes A protein modification that effectively replaces one hydrogen atom with one acetyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Ac1Res Acetylation (N terminus, N epsilon of Lysine, O of Serine) (Ac) PSI-MOD Acetyl Acetylation MOD:00394 Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). From DeltaMass: Average Mass: 42 monoacetylated residue MOD:00394 A protein modification that effectively replaces one hydrogen atom with one acetyl group. DeltaMass:0 PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 Unimod:1 DiffAvg: 42.04 DiffFormula: C 2 H 2 O 1 DiffMono: 42.010565 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:1 Ac1Res Acetylation (N terminus, N epsilon of Lysine, O of Serine) (Ac) Acetyl Acetylation A protein modification that crosslinks two residues by formation of a thioester bond between a cysteine thiol and either an alpha-carbonyl, as in S-(L-methionyl-L-cysteine), or a sidechain carbonyl, as in S-(L-isoglutamyl)-L-cysteine. PSI-MOD MOD:00395 thioester crosslinked residues MOD:00395 A protein modification that crosslinks two residues by formation of a thioester bond between a cysteine thiol and either an alpha-carbonyl, as in S-(L-methionyl-L-cysteine), or a sidechain carbonyl, as in S-(L-isoglutamyl)-L-cysteine. PubMed:18688235 A protein modification that effectively replaces a residue hydrogen atom on an oxygen with a carbohydrate-like group through a glycosidic bond. OGlycoRes PSI-MOD MOD:00396 O-glycosylated residue MOD:00396 A protein modification that effectively replaces a residue hydrogen atom on an oxygen with a carbohydrate-like group through a glycosidic bond. PubMed:18688235 OGlycoRes A protein modification that is produced by reaction with iodoacetamide, usually replacement of a reactive hydrogen with a methylcarboxamido group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Carbamidomethyl Iodoacetamide derivative MOD:00397 iodoacetamide derivatized residue MOD:00397 A protein modification that is produced by reaction with iodoacetamide, usually replacement of a reactive hydrogen with a methylcarboxamido group. PubMed:11327326 PubMed:11510821 PubMed:12422359 Unimod:4 DiffAvg: 57.05 DiffFormula: C 2 H 3 N 1 O 1 DiffMono: 57.021464 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:4 Carbamidomethyl Iodoacetamide derivative A protein modification that effectively replaces a hydrogen atom with a carbamoyl (carboxamido) group. Replacement of an amino hydrogen produces a ureido group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Carbamylation PSI-MOD Carbamyl Carbamylation MOD:00398 This modification can be produced by hydrogen cyanate, either used as a reagent or as released by urea degradation in solution [JSG]. carbamoylated residue MOD:00398 A protein modification that effectively replaces a hydrogen atom with a carbamoyl (carboxamido) group. Replacement of an amino hydrogen produces a ureido group. DeltaMass:56 PubMed:10978403 PubMed:12203680 Unimod:5 DiffAvg: 43.02 DiffFormula: C 1 H 1 N 1 O 1 DiffMono: 43.005814 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:5 Carbamylation Carbamyl Carbamylation A protein modification that is produced by reaction with iodoacetic acid, usually replacement of a reactive hydrogen with a methylcarboxy group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Carboxymethyl (on Cysteine) PSI-MOD Carboxymethyl Iodoacetic acid derivative MOD:00399 From DeltaMass: Average Mass: 58 Abbreviation:CmC Average Mass Change:58 Notes:Cysteine reacts with iodoacetic acid to produce carboxymethyl cysteine. iodoacetic acid derivatized residue MOD:00399 A protein modification that is produced by reaction with iodoacetic acid, usually replacement of a reactive hydrogen with a methylcarboxy group. DeltaMass:64 Unimod:6 DiffAvg: 58.04 DiffFormula: C 2 H 2 O 2 DiffMono: 58.005479 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:6 Carboxymethyl (on Cysteine) Carboxymethyl Iodoacetic acid derivative A protein modification that effectively replaces a carboxamido group with a carboxyl group, with both a gain of oxygen and loss of a nitrogen and a hydrogen. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Deamidation of Asparagine and Glutamine to Aspartate and Glutamate dNRes deamidationkq PSI-MOD Deamidated Deamidation MOD:00400 From DeltaMass: References:Vish Katta. deamidated residue MOD:00400 A protein modification that effectively replaces a carboxamido group with a carboxyl group, with both a gain of oxygen and loss of a nitrogen and a hydrogen. DeltaMass:32 OMSSA:4 Unimod:7 DiffAvg: 0.98 DiffFormula: H -1 N -1 O 1 DiffMono: 0.984016 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:7 Deamidation of Asparagine and Glutamine to Aspartate and Glutamate dNRes deamidationkq Deamidated Deamidation A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d0 reagent. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Gygi ICAT(TM) d0 ICAT-G MOD:00401 Gygi ICAT(TM) d0 modified cysteine MOD:00401 A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d0 reagent. PubMed:10504701 Unimod:8#C DiffAvg: 486.63 DiffFormula: C 22 H 38 N 4 O 6 S 1 DiffMono: 486.251206 Formula: C 25 H 43 N 5 O 7 S 2 MassAvg: 589.77 MassMono: 589.260391 Origin: C Source: artifact TermSpec: none Unimod: Unimod:8 Gygi ICAT(TM) d0 ICAT-G A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d8 reagent. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Gygi ICAT(TM) d8 ICAT-G:2H(8) MOD:00402 Gygi ICAT(TM) d8 modified cysteine MOD:00402 A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d8 reagent. PubMed:10504701 Unimod:9#C DiffAvg: 494.30 DiffFormula: C 22 (1)H 30 (2)H 8 N 4 O 6 S 1 DiffMono: 494.301420 Formula: C 25 (1)H 35 (2)H 8 N 5 O 7 S 2 MassAvg: 597.31 MassMono: 597.310605 Origin: C Source: artifact TermSpec: none Unimod: Unimod:9 Gygi ICAT(TM) d8 ICAT-G:2H(8) A protein modification that effectively converts an L-methionine residue to homoserine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Homoserine formed from Met by CNBr treatment ctermpephsem PSI-MOD Homoserine Met->Hse MOD:00403 Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group and the following residue amino group. homoserine MOD:00403 A protein modification that effectively converts an L-methionine residue to homoserine. DeltaMass:113 OMSSA:56 Unimod:10#M DiffAvg: -30.09 DiffFormula: C -1 H -2 O 1 S -1 DiffMono: -29.992806 Formula: C 4 H 7 N 1 O 2 MassAvg: 101.10 MassMono: 101.047678 Origin: M Source: artifact TermSpec: C-term Unimod: Unimod:10 Homoserine formed from Met by CNBr treatment ctermpephsem Homoserine Met->Hse A protein modification that effectively converts an L-methionine residue to homoserine lactone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: ctermpephselactm PSI-MOD Homoserine lactone Met->Hsl MOD:00404 Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group. Under acid conditions the homoserine dehydrates to form the cyclic lactone. homoserine lactone MOD:00404 A protein modification that effectively converts an L-methionine residue to homoserine lactone. DeltaMass:90 OMSSA:57 Unimod:11#M DiffAvg: -48.10 DiffFormula: C -1 H -4 S -1 DiffMono: -48.003371 Formula: C 4 H 5 N 1 O 1 MassAvg: 83.09 MassMono: 83.037114 Origin: M Source: artifact TermSpec: C-term Unimod: Unimod:11 ctermpephselactm Homoserine lactone Met->Hsl A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d8 reagent. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Applied Biosystems original ICAT(TM) d8 ICAT-D:2H(8) MOD:00405 Applied Biosystems original ICAT(TM) d8 modified cysteine MOD:00405 A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d8 reagent. Unimod:12#C DiffAvg: 450.28 DiffFormula: C 20 (1)H 26 (2)H 8 N 4 O 5 S 1 DiffMono: 450.275205 Formula: C 23 (1)H 31 (2)H 8 N 5 O 6 S 2 MassAvg: 553.28 MassMono: 553.284390 Origin: C Source: artifact TermSpec: none Unimod: Unimod:12 Applied Biosystems original ICAT(TM) d8 ICAT-D:2H(8) A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d0 reagent. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Applied Biosystems original ICAT(TM) d0 ICAT-D MOD:00406 Applied Biosystems original ICAT(TM) d0 modified cysteine MOD:00406 A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d0 reagent. Unimod:13#C DiffAvg: 442.22 DiffFormula: C 20 (1)H 34 N 4 O 5 S 1 DiffMono: 442.224991 Formula: C 23 (1)H 39 N 5 O 6 S 2 MassAvg: 545.23 MassMono: 545.234176 Origin: C Source: artifact TermSpec: none Unimod: Unimod:13 Applied Biosystems original ICAT(TM) d0 ICAT-D A protein modification that effectively replaces a carboxyl group with a carboxy methyl ester group. OBSOLETE because Unimod:14 merged with entry 34, remap to MOD:00599. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: ResOMe PSI-MOD MOD:00407 residue methyl ester true MOD:00407 A protein modification that effectively replaces a carboxyl group with a carboxy methyl ester group. OBSOLETE because Unimod:14 merged with entry 34, remap to MOD:00599. PubMed:18688235 DiffAvg: 14.03 DiffFormula: C 1 H 2 DiffMono: 14.015650 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00599 Source: none TermSpec: none ResOMe A protein modification that effectively replaces a residue amino or imino hydrogen with an acetyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N-Acetyl N-Acetylation NAcRes PSI-MOD MOD:00408 mono N-acetylated residue MOD:00408 A protein modification that effectively replaces a residue amino or imino hydrogen with an acetyl group. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 O 1 DiffMono: 42.010565 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none N-Acetyl N-Acetylation NAcRes A protein modification that effectively replaces a residue amino group with a formamido group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: NFoRes ntermformyl ntermpepformyl PSI-MOD Formyl MOD:00409 N-formylated residue MOD:00409 A protein modification that effectively replaces a residue amino group with a formamido group. OMSSA:44 OMSSA:82 DiffAvg: 28.01 DiffFormula: C 1 O 1 DiffMono: 27.994915 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none NFoRes ntermformyl ntermpepformyl Formyl A protein modification that effectively converts an L-cysteine residue to S-(N-isopropylcarboxamidomethyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: nipcam PSI-MOD N-isopropylcarboxamidomethyl NIPCAM MOD:00410 S-(N-isopropylcarboxamidomethyl)-L-cysteine MOD:00410 A protein modification that effectively converts an L-cysteine residue to S-(N-isopropylcarboxamidomethyl)-L-cysteine. OMSSA:84 PubMed:11465505 PubMed:8465942 Unimod:17#C DiffAvg: 99.13 DiffFormula: C 5 H 9 N 1 O 1 S 0 DiffMono: 99.068414 Formula: C 8 H 14 N 2 O 2 S 1 MassAvg: 202.27 MassMono: 202.077599 Origin: C Source: artifact TermSpec: none Unimod: Unimod:17 nipcam N-isopropylcarboxamidomethyl NIPCAM modification from Unimod Isotopic label. OBSOLETE because Unimod:18 is now merged with entry 258 remap to MOD:00581 'single 018 label' DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00411 A modification from Unimod:18 O18 label true MOD:00411 modification from Unimod Isotopic label. OBSOLETE because Unimod:18 is now merged with entry 258 remap to MOD:00581 'single 018 label' PubMed:18688235 DiffAvg: 2.00 DiffFormula: (16)O -1 (18)O 1 DiffMono: 2.004246 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00581 Source: artifact TermSpec: none modification from Unimod artifact. OBSOLETE because Unimod entry 19 is now merged with Unimod 35 remap to MOD:00425 'monohydroxylated residue'. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00412 oxidation true MOD:00412 modification from Unimod artifact. OBSOLETE because Unimod entry 19 is now merged with Unimod 35 remap to MOD:00425 'monohydroxylated residue'. PubMed:18688235 DiffAvg: 16.00 DiffFormula: O 1 DiffMono: 15.994915 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00425 Source: none TermSpec: none A protein modification that is produced by reaction of a cysteine residue with biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine PEO-Iodoacetyl-LC-Biotin MOD:00413 biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine derivatized cysteine MOD:00413 A protein modification that is produced by reaction of a cysteine residue with biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine. Unimod:20#C DiffAvg: 414.52 DiffFormula: C 18 H 30 N 4 O 5 S 1 DiffMono: 414.193691 Formula: C 21 H 35 N 5 O 6 S 2 MassAvg: 517.66 MassMono: 517.202876 Origin: C Source: artifact TermSpec: none Unimod: Unimod:20 Biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine PEO-Iodoacetyl-LC-Biotin A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with one methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Me1Arg N-methyl Arginyl methylr PSI-MOD Methyl MOD:00414 From DeltaMass: formula incorrect, N and O reversed monomethylated L-arginine MOD:00414 A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with one methyl group. DeltaMass:215 OMSSA:77 Unimod:34#R DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 14 N 4 O 1 MassAvg: 170.22 MassMono: 170.116761 Origin: R Source: none TermSpec: none Unimod: Unimod:34 Me1Arg N-methyl Arginyl methylr Methyl modification from Unimod - OBSOLETE because Unimod entry 22 is now merged with entry 21 remap to MOD:00696 'phosphorylated residue'. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00415 phosphorylation without neutral loss true MOD:00415 modification from Unimod - OBSOLETE because Unimod entry 22 is now merged with entry 21 remap to MOD:00696 'phosphorylated residue'. PubMed:18688235 DiffAvg: 79.98 DiffFormula: H 1 O 3 P 1 DiffMono: 79.966331 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00696 Source: artifact TermSpec: none A change resulting in an alteration of the measured molecular mass of a peptide or protein hydroxyl amino acid phosphorylated promptly followed by secondary loss of a neutral trihydrogen phosphate molecular fragment. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Dehydrated Dehydration MOD:00416 O4-phosphotyrosine does not lose phosphate by this mechanism. Unimod does not provide a citation for this particular modification [JSG]. phosphorylation of an hydroxyl amino acid with prompt loss of phosphate MOD:00416 A change resulting in an alteration of the measured molecular mass of a peptide or protein hydroxyl amino acid phosphorylated promptly followed by secondary loss of a neutral trihydrogen phosphate molecular fragment. Unimod:23 DiffAvg: -18.02 DiffFormula: H -2 O -1 DiffMono: -18.010565 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:23 Dehydrated Dehydration A protein modification that effectively converts an L-cysteine residue to S-carboxamidoethyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PAM-Cys Propionamide or Acrylamide adduct S-(3-amino-3-oxopropyl)cysteine S-carbamoylethyl-L-cysteine S-propanamide-L-cysteine propionamidec PSI-MOD Acrylamide adduct Propionamide MOD:00417 From DeltaMass: References: Anal. Biochem. Vol 216 No. 1 p131 (citation not found) Notes: Residual acrylamide in SDS gels can label free cysteines to produce propionamido-Cys (also known as PAM-Cys) S-carboxamidoethyl-L-cysteine MOD:00417 A protein modification that effectively converts an L-cysteine residue to S-carboxamidoethyl-L-cysteine. DeltaMass:72 OMSSA:5 PubMed:1481983 Unimod:24#C DiffAvg: 71.08 DiffFormula: C 3 H 5 N 1 O 1 S 0 DiffMono: 71.037114 Formula: C 6 H 10 N 2 O 2 S 1 MassAvg: 174.22 MassMono: 174.046299 Origin: C Source: artifact TermSpec: none Unimod: Unimod:24 PAM-Cys Propionamide or Acrylamide adduct S-(3-amino-3-oxopropyl)cysteine S-carbamoylethyl-L-cysteine S-propanamide-L-cysteine propionamidec Acrylamide adduct Propionamide A protein modification that effectively replaces a hydrogen atom with an (pyridin-3-yl)acetyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Pyridylacetyl pyridylacetyl MOD:00418 Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. pyridylacetylated residue MOD:00418 A protein modification that effectively replaces a hydrogen atom with an (pyridin-3-yl)acetyl group. PubMed:9276974 Unimod:25 DiffAvg: 119.12 DiffFormula: C 7 H 5 N 1 O 1 DiffMono: 119.037114 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:25 Pyridylacetyl pyridylacetyl A protein modification that effectively converts an L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid 5-oxothiomorpholine-3-carboxylic acid Otc S-carbamoylmethylcysteine cyclization (N-terminus) PSI-MOD Pyro-carbamidomethyl S-carbamoylmethylcysteine cyclization (N-terminus) MOD:00419 From DeltaMass: A secondary modification affecting peptides with S-carbamoylmethyl-L-cysteine (CamC) at the N-terminus. These exist in enzymatic digests of proteins that have been S-alkylated with iodoacetamide. Cyclization of N-terminal CamC gives a residue of (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid. Peptides in which this has occurred become more hydrophobic, and lose 17 Da from the N-terminal residue. (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid MOD:00419 A protein modification that effectively converts an L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid. DeltaMass:336 PubMed:12643538 Unimod:26#C DiffAvg: 40.02 DiffFormula: C 2 H 0 N 0 O 1 S 0 DiffMono: 39.994915 Formula: C 5 H 6 N 1 O 2 S 1 MassAvg: 144.17 MassMono: 144.011924 Origin: C Source: artifact TermSpec: N-term Unimod: Unimod:26 (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid 5-oxothiomorpholine-3-carboxylic acid Otc S-carbamoylmethylcysteine cyclization (N-terminus) Pyro-carbamidomethyl S-carbamoylmethylcysteine cyclization (N-terminus) A protein modification that effectively converts an L-glutamic acid residue to 2-pyrrolidone-5-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0262 (2S)-5-oxo-2-pyrrolidinecarboxylic acid 2-oxopyrrolidine-5-carboxylic acid 2-pyrrolidone-5-carboxylic acid 5-oxoproline 5-oxopyrrolidine-2-carboxylic acid 5-pyrrolidone-2-carboxylic acid MOD_RES Pyrrolidone carboxylic acid (Glu) PCA PyrGlu(Glu) Pyroglutamic Acid formed from Glutamic Acid ntermpeppyroe pyroglutamic acid PSI-MOD Glu->pyro-Glu Pyro-glu from E MOD:00420 From DeltaMass: References: The conversion of glutamic acid to pyroglutamic was reported for the beta-amyloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52 [DeltaMass]. The modification in amyloid protein is probably an artifact of treatment with strong acid under anhydrous conditions. Peptides with N-terminal glutamic acid isolated from single cells of Aplysia neurons show partial conversion to pyroglutamic acid, possibly dependent on a temperature sensitive factor [JSG]. 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420 A protein modification that effectively converts an L-glutamic acid residue to 2-pyrrolidone-5-carboxylic acid. DeltaMass:16 OMSSA:109 PubMed:10214721 PubMed:1836357 PubMed:3473473 PubMed:8382902 RESID:AA0031#GLU Unimod:27#E DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 5 H 6 N 1 O 2 MassAvg: 112.11 MassMono: 112.039853 Origin: E Source: artifact TermSpec: N-term Unimod: Unimod:27 (2S)-5-oxo-2-pyrrolidinecarboxylic acid 2-oxopyrrolidine-5-carboxylic acid 2-pyrrolidone-5-carboxylic acid 5-oxoproline 5-oxopyrrolidine-2-carboxylic acid 5-pyrrolidone-2-carboxylic acid MOD_RES Pyrrolidone carboxylic acid (Glu) PCA PyrGlu(Glu) Pyroglutamic Acid formed from Glutamic Acid ntermpeppyroe pyroglutamic acid Glu->pyro-Glu Pyro-glu from E A protein modification that effectively replaces a residue hydrogen atom on a carbon with a carbohydrate-like group through a glycosidic bond. CGlycoRes PSI-MOD MOD:00421 C-glycosylated residue MOD:00421 A protein modification that effectively replaces a residue hydrogen atom on a carbon with a carbohydrate-like group through a glycosidic bond. PubMed:18688235 CGlycoRes A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a morpholine-2-acetyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N-succinimidylmorpholine-2-acetate alpha-amino derivative PSI-MOD N-Succinimidyl-2-morpholine acetate SMA MOD:00422 The Unimod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. alpha-amino morpholine-2-acetylated residue MOD:00422 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a morpholine-2-acetyl group. PubMed:10446193 Unimod:29#N-term DiffAvg: 127.14 DiffFormula: C 6 H 9 N 1 O 2 DiffMono: 127.063329 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:29 N-succinimidylmorpholine-2-acetate alpha-amino derivative N-Succinimidyl-2-morpholine acetate SMA A protein modification that effectively substitutes one sodium atom for one hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: Na1Res Sodium PSI-MOD Cation:Na Sodium adduct MOD:00423 monosodium salt MOD:00423 A protein modification that effectively substitutes one sodium atom for one hydrogen atom. DeltaMass:0 Unimod:30 DiffAvg: 21.98 DiffFormula: H -1 Na 1 DiffMono: 21.981944 Formula: none MassAvg: none MassMono: none Origin: X TermSpec: none Unimod: Unimod:30 Na1Res Sodium Cation:Na Sodium adduct A protein modification that effectively converts an L-cysteine residue to S-pyridylethyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PECys Pyridylethyl Cystenyl S-pyridinylethyl-L-cysteine spyridylethylc vinylpyridine derivatized cysteine residue PSI-MOD Pyridylethyl S-pyridylethylation MOD:00424 From DeltaMass: Formula:C10H12O2N1S1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:208.067 Average Mass Change:208.286 (mass incorrect, aggregate not delta) References:PE Sciex S-pyridylethyl-L-cysteine MOD:00424 A protein modification that effectively converts an L-cysteine residue to S-pyridylethyl-L-cysteine. DeltaMass:253 OMSSA:112 PubMed:11760118 PubMed:626389 PubMed:8297018 PubMed:8783016 Unimod:31#C DiffAvg: 105.14 DiffFormula: C 7 H 7 N 1 DiffMono: 105.057849 Formula: C 10 H 12 N 2 O 1 S 1 MassAvg: 208.28 MassMono: 208.067034 Origin: C Source: artifact TermSpec: none Unimod: Unimod:31 PECys Pyridylethyl Cystenyl S-pyridinylethyl-L-cysteine spyridylethylc vinylpyridine derivatized cysteine residue Pyridylethyl S-pyridylethylation A protein modification that effectively replaces one hydrogen atom with a hydroxyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Hy1Res PSI-MOD Oxidation Oxidation or Hydroxylation MOD:00425 monohydroxylated residue MOD:00425 A protein modification that effectively replaces one hydrogen atom with a hydroxyl group. Unimod:35 DiffAvg: 16.00 DiffFormula: O 1 DiffMono: 15.994915 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:35 Hy1Res Oxidation Oxidation or Hydroxylation A protein modification that effectively replaces a residue hydrogen atom on a sulfur with a carbohydrate-like group through a glycosidic bond. SGlycoRes PSI-MOD MOD:00426 S-glycosylated residue MOD:00426 A protein modification that effectively replaces a residue hydrogen atom on a sulfur with a carbohydrate-like group through a glycosidic bond. PubMed:18688235 SGlycoRes A protein modification that effectively replaces a hydrogen atom with a methyl group. MeRes Methylation (N terminus, N epsilon of Lysine, O of Serine, Threonine or C terminus, N of Asparagine) PSI-MOD MOD:00427 From DeltaMass: Average Mass: 14 Average Mass Change:14 References:Methylation of Asparagine (found in phycobiliproteins) Klotz and Glazer (1987) J. Biol. Chem. 262; 17350-17355 methylated residue MOD:00427 A protein modification that effectively replaces a hydrogen atom with a methyl group. DeltaMass:36 MeRes Methylation (N terminus, N epsilon of Lysine, O of Serine, Threonine or C terminus, N of Asparagine) A protein modification that effectively replaces two hydrogen atoms with two hydroxyl groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Hy2Res PSI-MOD Dioxidation dihydroxy MOD:00428 dihydroxylated residue MOD:00428 A protein modification that effectively replaces two hydrogen atoms with two hydroxyl groups. PubMed:12686488 Unimod:425 DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:425 Hy2Res Dioxidation dihydroxy A protein modification that effectively replaces two hydrogen atoms with two methyl groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Me2Res N,N dimethylation (of Arginine or Lysine) PSI-MOD Dimethyl di-Methylation MOD:00429 For amino-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts only for dimethylation and not protonation. The alternative Me2+Res process accounts for both protonation and dimethylation [JSG]. dimethylated residue MOD:00429 A protein modification that effectively replaces two hydrogen atoms with two methyl groups. DeltaMass:0 PubMed:12964758 PubMed:14570711 Unimod:36 DiffAvg: 28.05 DiffFormula: C 2 H 4 DiffMono: 28.031300 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:36 Me2Res N,N dimethylation (of Arginine or Lysine) Dimethyl di-Methylation A protein modification that effectively replaces three hydrogen atoms with three methyl groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Me3Res PSI-MOD Trimethyl tri-Methylation MOD:00430 For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative Me3+Res process accounts for both protonation and trimethylation. trimethylated residue MOD:00430 A protein modification that effectively replaces three hydrogen atoms with three methyl groups. PubMed:12590383 PubMed:3145979 PubMed:4304194 PubMed:6778808 PubMed:7093227 PubMed:8453381 Unimod:37 DiffAvg: 42.08 DiffFormula: C 3 H 6 DiffMono: 42.046950 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:37 Me3Res Trimethyl tri-Methylation Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral molecular fragment. NLModRes PSI-MOD MOD:00431 modified residue with a secondary neutral loss MOD:00431 Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral molecular fragment. PubMed:18688235 NLModRes Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment. dPhosModRes PSI-MOD MOD:00432 modified residue with neutral loss of phosphate MOD:00432 Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment. PubMed:18688235 dPhosModRes A protein modification that effectively replaces a hydrogen atom with an glucose group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: GlcRes PSI-MOD MOD:00433 monoglucosylated residue MOD:00433 A protein modification that effectively replaces a hydrogen atom with an glucose group through a glycosidic bond. PubMed:18688235 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none GlcRes A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexose sugar group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Hex Hexoses (Fru, Gal, Glc, Man) O-Glycosyl- PSI-MOD Hex Hexose MOD:00434 From DeltaMass: Average Mass: 162 Formula:C6 H10 05 Monoisotopic Mass Change:162.053 Average Mass Change:162.143 References:PE Sciex. hexosylated residue MOD:00434 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexose sugar group through a glycosidic bond. DeltaMass:203 PubMed:15279557 Unimod:41 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:41 Hex Hexoses (Fru, Gal, Glc, Man) O-Glycosyl- Hex Hexose Covalent modification of a peptide or protein amino acid phosphorylated serine with a secondary loss of a neutral trihydrogen phosphate molecular fragment. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: dPhosOPhosSer PSI-MOD MOD:00435 O-phospho-L-serine with neutral loss of phosphate MOD:00435 Covalent modification of a peptide or protein amino acid phosphorylated serine with a secondary loss of a neutral trihydrogen phosphate molecular fragment. PubMed:18688235 DiffAvg: -97.99 DiffFormula: C 0 H -3 N 0 O -4 P -1 DiffMono: -97.976895 Formula: C 3 H 3 N 1 O 1 MassAvg: 69.06 MassMono: 69.021464 Origin: MOD:00046 Source: artifact TermSpec: none dPhosOPhosSer A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylhexosamine group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: HexNAc PSI-MOD HexNAc N-Acetylhexosamine MOD:00436 N-acetylhexosaminylated residue MOD:00436 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylhexosamine group through a glycosidic bond. PubMed:18688235 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: none GNOme: GNO:G29068FM MassAvg: none MassMono: none Origin: X Source: none TermSpec: none HexNAc HexNAc N-Acetylhexosamine A protein modification that effectively replaces a hydrogen atom with a farnesyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: FarnRes Farnesylation PSI-MOD Farnesyl Farnesylation MOD:00437 From DeltaMass: Average Mass: 204 farnesylated residue MOD:00437 A protein modification that effectively replaces a hydrogen atom with a farnesyl group. DeltaMass:0 PubMed:15609361 Unimod:44 DiffAvg: 204.36 DiffFormula: C 15 H 24 DiffMono: 204.187801 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:44 FarnRes Farnesylation Farnesyl Farnesylation A protein modification that effectively replaces a hydrogen atom with a myristoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: C14:0 aliphatic acylated residue MyrRes Myristoylation PSI-MOD Myristoyl Myristoylation MOD:00438 From DeltaMass: Average Mass: 210 myristoylated residue MOD:00438 A protein modification that effectively replaces a hydrogen atom with a myristoyl group. DeltaMass:0 Unimod:45 DiffAvg: 210.36 DiffFormula: C 14 H 26 O 1 DiffMono: 210.198365 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:45 C14:0 aliphatic acylated residue MyrRes Myristoylation Myristoyl Myristoylation Covalent modification of a peptide or protein amino acid phosphorylated threonine with a secondary loss of a neutral trihydrogen phosphate molecular fragment. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: dPhosOPhosThr PSI-MOD MOD:00439 O-phospho-L-threonine with neutral loss of phosphate MOD:00439 Covalent modification of a peptide or protein amino acid phosphorylated threonine with a secondary loss of a neutral trihydrogen phosphate molecular fragment. PubMed:18688235 DiffAvg: -97.99 DiffFormula: C 0 H -3 N 0 O -4 P -1 DiffMono: -97.976895 Formula: C 4 H 5 N 1 O 1 MassAvg: 83.09 MassMono: 83.037114 Origin: MOD:00047 Source: artifact TermSpec: none dPhosOPhosThr A protein modification that effectively replaces a hydrogen atom with a palmitoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Hexadecanoylated residue Palmitoylation PamRes PSI-MOD Palmitoyl Palmitoylation MOD:00440 From DeltaMass: Average Mass: 238 palmitoylated residue MOD:00440 A protein modification that effectively replaces a hydrogen atom with a palmitoyl group. DeltaMass:0 DiffAvg: 238.41 DiffFormula: C 16 H 30 O 1 DiffMono: 238.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Hexadecanoylated residue Palmitoylation PamRes Palmitoyl Palmitoylation A protein modification that effectively replaces a hydrogen atom with a geranylgeranyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Geranylgeranylation GergerRes PSI-MOD Geranyl-geranyl GeranylGeranyl MOD:00441 From DeltaMass: Average Mass: 272 geranylgeranylated residue MOD:00441 A protein modification that effectively replaces a hydrogen atom with a geranylgeranyl group. DeltaMass:0 PubMed:15609361 Unimod:48 DiffAvg: 272.48 DiffFormula: C 20 H 32 DiffMono: 272.250401 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:48 Geranylgeranylation GergerRes Geranyl-geranyl GeranylGeranyl Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N'-dimethylated L-arginine with secondary loss of an N,N'-carbodiimide molecular fragment. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: dCDI-NNMe2+Arg PSI-MOD MOD:00442 protonated omega-N,omega-N'-dimethylated L-arginine with secondary neutral loss of N,N'-carbodiimide MOD:00442 Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N'-dimethylated L-arginine with secondary loss of an N,N'-carbodiimide molecular fragment. PubMed:15835918 PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 1 H 2 N 2 O 0 DiffMono: 42.021798 Formula: C 7 H 14 N 2 O 1 MassAvg: 142.20 MassMono: 142.110613 Origin: R Source: artifact TermSpec: none dCDI-NNMe2+Arg Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of an N,N-dimethylamine molecular fragment. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: dDMA-NoMe2+Arg PSI-MOD MOD:00443 protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of N,N-dimethylamine MOD:00443 Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of an N,N-dimethylamine molecular fragment. PubMed:15835918 PubMed:18688235 DiffAvg: 59.09 DiffFormula: C 2 H 7 N 2 DiffMono: 59.060923 Formula: C 6 H 10 N 3 O 1 MassAvg: 140.17 MassMono: 140.082387 Origin: R Source: artifact TermSpec: none dDMA-NoMe2+Arg A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: ntermpeptripalmitatec PSI-MOD N-acyl diglyceride cysteine Tripalmitate MOD:00444 N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine MOD:00444 A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine. OMSSA:118 PubMed:10356335 Unimod:51 DiffAvg: 789.32 DiffFormula: C 51 H 96 O 5 DiffMono: 788.725776 Formula: C 54 H 101 N 1 O 6 S 1 MassAvg: 892.46 MassMono: 891.734961 Origin: C Source: natural TermSpec: N-term Unimod: Unimod:51 ntermpeptripalmitatec N-acyl diglyceride cysteine Tripalmitate A protein modification that effectively converts an L-lysine residue to L-homoarginine, such as reaction with O-methylisourea. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: guanidinationk PSI-MOD Guanidination Guanidinyl MOD:00445 L-homoarginine MOD:00445 A protein modification that effectively converts an L-lysine residue to L-homoarginine, such as reaction with O-methylisourea. OMSSA:53 PubMed:11078590 PubMed:11085420 PubMed:11821862 Unimod:52 DiffAvg: 42.04 DiffFormula: C 1 H 2 N 2 DiffMono: 42.021798 Formula: C 7 H 14 N 4 O 1 MassAvg: 170.22 MassMono: 170.116761 Origin: K Source: artifact TermSpec: none Unimod: Unimod:52 guanidinationk Guanidination Guanidinyl A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 4-hydroxynonenal (HNE) HNE MOD:00446 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. 4-hydroxynonenal adduct MOD:00446 A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal. PubMed:11327326 PubMed:15133838 Unimod:53 DiffAvg: 156.22 DiffFormula: C 9 H 16 O 2 DiffMono: 156.115030 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:53 4-hydroxynonenal (HNE) HNE A protein modification that effectively results from forming an adduct with a glucuronic acid either through a carboxyl group amide or ester bond, or through C1-glycosylation. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N-Glucuronyl (N terminus) PSI-MOD Glucuronyl N-glucuronylation MOD:00447 N-glucuronylated residue MOD:00447 A protein modification that effectively results from forming an adduct with a glucuronic acid either through a carboxyl group amide or ester bond, or through C1-glycosylation. DeltaMass:0 PubMed:7398618 Unimod:54#N-term DiffAvg: 176.12 DiffFormula: C 6 H 8 O 6 DiffMono: 176.032088 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:54 N-Glucuronyl (N terminus) Glucuronyl N-glucuronylation A protein modification that effectively replaces a hydrogen atom with an N-acetylaminoglucose group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: GlcNAcRes PSI-MOD HexNAc MOD:00448 mono-N-acetylaminoglucosylated residue MOD:00448 A protein modification that effectively replaces a hydrogen atom with an N-acetylaminoglucose group through a glycosidic bond. PubMed:18688235 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none GlcNAcRes HexNAc modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acetate labeling reagent (N-term & K) (heavy form, +3amu) Acetyl:2H(3) MOD:00449 acetate labeling reagent (N-term) (heavy form, +3amu) MOD:00449 modification from Unimod Isotopic label PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:56 DiffAvg: 45.03 DiffFormula: C 2 (1)H -1 (2)H 3 O 1 DiffMono: 45.029395 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:56 Acetate labeling reagent (N-term & K) (heavy form, +3amu) Acetyl:2H(3) OBSOLETE because this isotopic label from Unimod entry 57 is deprecated DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00450 acetate labeling reagent light form (K) true MOD:00450 OBSOLETE because this isotopic label from Unimod entry 57 is deprecated PubMed:11857757 DiffAvg: 42.01 DiffFormula: C 2 (1)H 2 O 1 DiffMono: 42.010565 Formula: none MassAvg: none MassMono: none Origin: K Source: artifact TermSpec: none A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a propanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Propionate labeling reagent light form (N-term & K) Propionyl MOD:00451 alpha-amino propanoylated residue MOD:00451 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a propanoyl group. PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:58#N-term DiffAvg: 56.06 DiffFormula: C 3 H 4 O 1 DiffMono: 56.026215 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:58 Propionate labeling reagent light form (N-term & K) Propionyl A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(13)C-labeled propanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Propionate labeling reagent heavy form (+3amu), N-term & K Propionyl:13C(3) MOD:00452 alpha-amino 3x(13)C-labeled propanoylated residue MOD:00452 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(13)C-labeled propanoyl group. PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:59#N-term DiffAvg: 59.04 DiffFormula: (13)C 3 H 4 O 1 DiffMono: 59.036279 Formula: (12)C 6 (13)C 3 H 16 N 2 O 2 MassAvg: 187.13 MassMono: 187.131242 Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:59 Propionate labeling reagent heavy form (+3amu), N-term & K Propionyl:13C(3) A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent light form group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GIST-Quat Quaternary amine labeling reagent light form (N-term & K) MOD:00453 quaternary amine labeling reagent light form (N-term & K) MOD:00453 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent light form group. PubMed:11857757 Unimod:60 DiffAvg: 127.19 DiffFormula: C 7 H 13 N 1 O 1 DiffMono: 127.099714 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:60 GIST-Quat Quaternary amine labeling reagent light form (N-term & K) A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+3amu) form group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GIST-Quat:2H(3) Quaternary amine labeling reagent heavy (+3amu) form, N-term & K MOD:00454 quaternary amine labeling reagent heavy form (+3amu) (N-term & K) MOD:00454 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+3amu) form group. PubMed:11857757 Unimod:61 DiffAvg: 130.12 DiffFormula: C 7 (1)H 10 (2)H 3 N 1 O 1 DiffMono: 130.118544 Formula: C 13 (1)H 22 (2)H 3 N 3 O 2 MassAvg: 258.21 MassMono: 258.213507 Origin: X Source: artifact TermSpec: none Unimod: Unimod:61 GIST-Quat:2H(3) Quaternary amine labeling reagent heavy (+3amu) form, N-term & K A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+6amu) form group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GIST-Quat:2H(6) Quaternary amine labeling reagent heavy form (+6amu), N-term & K MOD:00455 quaternary amine labeling reagent heavy form (+6amu) (N-term & K) MOD:00455 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+6amu) form group. PubMed:11857757 Unimod:62 DiffAvg: 133.14 DiffFormula: C 7 H 7 (2)H 6 N 1 O 1 DiffMono: 133.137375 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:62 GIST-Quat:2H(6) Quaternary amine labeling reagent heavy form (+6amu), N-term & K A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+9amu) form group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GIST-Quat:2H(9) Quaternary amine labeling reagent heavy form (+9amu), N-term & K MOD:00456 quaternary amine labeling reagent heavy form (+9amu) (N-term & K) MOD:00456 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+9amu) form group. PubMed:11857757 Unimod:63 DiffAvg: 136.16 DiffFormula: C 7 (1)H 4 (2)H 9 N 1 O 1 DiffMono: 136.156205 Formula: C 13 (1)H 16 (2)H 9 N 3 O 2 MassAvg: 264.25 MassMono: 264.251168 Origin: X Source: artifact TermSpec: none Unimod: Unimod:63 GIST-Quat:2H(9) Quaternary amine labeling reagent heavy form (+9amu), N-term & K A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a light succinyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Succinic anhydride labeling reagent light form (N-term) Succinyl MOD:00457 4x(12)C, 4x(1)H labeled alpha-amino succinylated residue MOD:00457 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a light succinyl group. PubMed:11857757 PubMed:12175151 Unimod:64#N-term DiffAvg: 100.03 DiffFormula: (12)C 4 (1)H 4 O 3 DiffMono: 100.016044 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: N-term Unimod: Unimod:64 Succinic anhydride labeling reagent light form (N-term) Succinyl A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(2)H labeled succinyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term Succinyl:2H(4) MOD:00458 4x(2)H labeled alpha-amino succinylated residue MOD:00458 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(2)H labeled succinyl group. PubMed:11857757 PubMed:12175151 Unimod:65#N-term DiffAvg: 104.04 DiffFormula: C 4 (2)H 4 O 3 DiffMono: 104.041151 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:65 Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term Succinyl:2H(4) A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(13)C labeled succinyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: PSI-MOD Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), N-term & K Succinyl:13C(4) MOD:00459 4x(13)C labeled alpha-amino succinylated residue MOD:00459 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(13)C labeled succinyl group. PubMed:11857757 PubMed:12175151 Unimod:66#N-term DiffAvg: 104.03 DiffFormula: (13)C 4 H 4 O 3 DiffMono: 104.029463 Formula: none MassAvg: none MassMono: none Origin: X TermSpec: none Unimod: Unimod:66 Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), N-term & K Succinyl:13C(4) A protein modification that effectively trioxygenates an L-cysteine residue to L-cysteine sulfonic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0634 (2R)-2-amino-3-sulfopropanoic acid 2-amino-2-carboxyethanesulfonic acid 2-azanyl-3-sulfopropanoic acid 3-sulfoalanine Cya CysO3H Cysteic acid, oxidation of cysteine L-cysteine sulfonic acid MOD_RES Cysteine sulfonic acid (-SO3H) cysteic acid cysteicacidc cysteine sulphonic acid PSI-MOD Trioxidation cysteine oxidation to cysteic acid MOD:00460 From DeltaMass: Notes:Treatment of cysteine by strongly oxidising reagents such as performic acid results in the complete oxidation of the sulphur atom. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. L-cysteic acid (L-cysteine sulfonic acid) MOD:00460 A protein modification that effectively trioxygenates an L-cysteine residue to L-cysteine sulfonic acid. ChEBI:17285 DeltaMass:334 OMSSA:34 PubMed:14678012 PubMed:18306178 PubMed:19522542 PubMed:9252331 RESID:AA0556 Unimod:345#C DiffAvg: 48.00 DiffFormula: C 0 H 0 N 0 O 3 S 0 DiffMono: 47.984744 Formula: C 3 H 5 N 1 O 4 S 1 MassAvg: 151.14 MassMono: 150.993929 Origin: C Source: artifact TermSpec: none Unimod: Unimod:345 (2R)-2-amino-3-sulfopropanoic acid 2-amino-2-carboxyethanesulfonic acid 2-azanyl-3-sulfopropanoic acid 3-sulfoalanine Cya CysO3H Cysteic acid, oxidation of cysteine L-cysteine sulfonic acid MOD_RES Cysteine sulfonic acid (-SO3H) cysteic acid cysteicacidc cysteine sulphonic acid Trioxidation cysteine oxidation to cysteic acid A protein modification that effectively substitutes a nitrite (NO2) group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: Nitro (NO2) PSI-MOD Nitro Oxidation to nitro MOD:00461 Note, this is often misrepresented as the introduction of a nitrate (NO3) group [JSG]. nitrated residue MOD:00461 A protein modification that effectively substitutes a nitrite (NO2) group for a hydrogen atom. DeltaMass:0 PubMed:8839040 PubMed:9252331 Unimod:354 DiffAvg: 45.00 DiffFormula: H -1 N 1 O 2 DiffMono: 44.985078 Formula: none MassAvg: none MassMono: none Origin: X TermSpec: none Unimod: Unimod:354 Nitro (NO2) Nitro Oxidation to nitro A protein modification that effectively converts an L-tryptophan residue to L-kynurenine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-4-(2-aminophenyl)-4-oxo-butanoic acid kynureninw PSI-MOD Trp->Kynurenin tryptophan oxidation to kynurenin MOD:00462 L-kynurenine MOD:00462 A protein modification that effectively converts an L-tryptophan residue to L-kynurenine. DeltaMass:357 OMSSA:66 PubMed:11029593 PubMed:9252331 Unimod:351#W DiffAvg: 3.99 DiffFormula: C -1 O 1 DiffMono: 3.994915 Formula: C 10 H 10 N 2 O 2 MassAvg: 190.20 MassMono: 190.074228 Origin: W Source: artifact TermSpec: none Unimod: Unimod:351 (2S)-2-amino-4-(2-aminophenyl)-4-oxo-butanoic acid kynureninw Trp->Kynurenin tryptophan oxidation to kynurenin A protein modification that effectively converts an L-tryptophan residue to 3'-hydroxy-L-kynurenine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: hydroxykynureninw PSI-MOD Trp->Hydroxykynurenin tryptophan oxidation to hydroxykynurenin MOD:00463 3'-hydroxy-L-kynurenine MOD:00463 A protein modification that effectively converts an L-tryptophan residue to 3'-hydroxy-L-kynurenine. OMSSA:58 PubMed:9252331 Unimod:350#W DiffAvg: 19.99 DiffFormula: C -1 O 2 DiffMono: 19.989829 Formula: C 10 H 10 N 2 O 3 MassAvg: 206.20 MassMono: 206.069142 Origin: W Source: artifact TermSpec: none Unimod: Unimod:350 hydroxykynureninw Trp->Hydroxykynurenin tryptophan oxidation to hydroxykynurenin A protein modification that effectively converts an L-tryptophan residue to N'-formyl-L-kynurenine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Double oxidation of Trp formylkynureninw PSI-MOD Dioxidation dihydroxy tryptophan oxidation to formylkynurenin MOD:00464 From DeltaMass: References:Willy V. Bienvenut, Catherine Déon, Carla Pasquarello, Jennifer M. Campbell, Jean-Charles Sanchez, Marvin L. Vestal, Denis F. Hochstrasser Matrix-assisted laser desorption/ionization-tandemmass spectrometry with high resolution andsensitivity for identification and characterizationof proteins. Proteomics 2002, 2, 868-876 Notes: A double oxidation of tryptophan for which the N-formylkynurenine (+32) structure can be proposed. Many minor peaks accompanying the main peak might also be attributed to other oxidation products of the tryptophan such as kynurenine (+4), an unknown by-product found in all oxidized tryptophan patterns (+13), hydroxytryptophan (+16), 3-hydroxykynurenine (+20) and hydroxy-N-formylkynurenine (+48). See proposed structures at http://www.abrf.org/images/misc/dmass32.jpg. N'-formyl-L-kynurenine MOD:00464 A protein modification that effectively converts an L-tryptophan residue to N'-formyl-L-kynurenine. DeltaMass:356 OMSSA:45 PubMed:12124932 PubMed:12686488 PubMed:9252331 Unimod:425#W DiffAvg: 32.00 DiffFormula: O 2 DiffMono: 31.989829 Formula: C 11 H 10 N 2 O 3 MassAvg: 218.21 MassMono: 218.069142 Origin: W Source: artifact TermSpec: none Unimod: Unimod:425 Double oxidation of Trp formylkynureninw Dioxidation dihydroxy tryptophan oxidation to formylkynurenin A protein modification that effectively converts an L-phenylalanine residue to a dihydroxyphenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: dihydroxyf PSI-MOD Dioxidation dihydroxy MOD:00465 Dihydroxyphenyalanines with a 4'-hydroxyl orginate naturally by a monohydroxylation of tyrosine, and not by dihydroxylation of phenylalanine [JSG]. dihydroxyphenylalanine (Phe) MOD:00465 A protein modification that effectively converts an L-phenylalanine residue to a dihydroxyphenylalanine. OMSSA:39 PubMed:1610822 PubMed:1903612 PubMed:3734192 PubMed:9252331 RESID:AA0146#var Unimod:425#F DiffAvg: 32.00 DiffFormula: O 2 DiffMono: 31.989829 Formula: C 9 H 9 N 1 O 3 MassAvg: 179.17 MassMono: 179.058243 Origin: F Source: artifact TermSpec: none Unimod: Unimod:425 dihydroxyf Dioxidation dihydroxy A protein modification that effectively converts a residue to a glycosylsphingolipidinositolethanolamidated. GSIRes PSI-MOD MOD:00466 glycosylsphingolipidinositolated residue MOD:00466 A protein modification that effectively converts a residue to a glycosylsphingolipidinositolethanolamidated. PubMed:12626404 PubMed:18688235 PubMed:8404891 GSIRes A protein modification that effectively substitutes an iminobiotinyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Iminobiotin Iminobiotinylation MOD:00467 iminobiotinyl modified residue MOD:00467 A protein modification that effectively substitutes an iminobiotinyl group for a hydrogen atom. PubMed:9750125 Unimod:89 DiffAvg: 225.31 DiffFormula: C 10 H 15 N 3 O 1 S 1 DiffMono: 225.093583 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:89 Iminobiotin Iminobiotinylation modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD ESP ESP-Tag light d0 MOD:00468 ESP-Tag light d0 MOD:00468 modification from Unimod Isotopic label Unimod:90 DiffAvg: 338.47 DiffFormula: C 16 H 26 N 4 O 2 S 1 DiffMono: 338.177647 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:90 ESP ESP-Tag light d0 modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD ESP-Tag heavy d10 ESP:2H(10) MOD:00469 ESP-Tag heavy d10 MOD:00469 modification from Unimod Isotopic label Unimod:91 DiffAvg: 348.24 DiffFormula: C 16 (1)H 16 (2)H 10 N 4 O 2 S 1 DiffMono: 348.240415 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:91 ESP-Tag heavy d10 ESP:2H(10) modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD NHS-LC-Biotin MOD:00470 NHS-LC-Biotin MOD:00470 modification from Unimod Chemical derivative Unimod:92 DiffAvg: 339.45 DiffFormula: C 16 H 25 N 3 O 3 S 1 DiffMono: 339.161663 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:92 NHS-LC-Biotin NHS-LC-Biotin modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD EDT-maleimide-PEO-biotin MOD:00471 EDT-maleimide-PEO-biotin MOD:00471 modification from Unimod Chemical derivative Unimod:93 DiffAvg: 601.80 DiffFormula: C 25 H 39 N 5 O 6 S 3 DiffMono: 601.206247 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:93 EDT-maleimide-PEO-biotin EDT-maleimide-PEO-biotin modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD IMID IMID d0 MOD:00472 IMID d0 MOD:00472 modification from Unimod Isotopic label PubMed:11746907 URL:http://dx.doi.org/10.1002/rcm.517 Unimod:94 DiffAvg: 68.04 DiffFormula: C 3 (1)H 4 N 2 DiffMono: 68.037448 Formula: C 9 H 16 N 4 O 1 MassAvg: 196.13 MassMono: 196.132411 Origin: K Source: artifact TermSpec: none Unimod: Unimod:94 IMID IMID d0 modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD IMID d4 IMID:2H(4) MOD:00473 IMID d4 MOD:00473 modification from Unimod Isotopic label PubMed:11746907 URL:http://dx.doi.org/10.1002/rcm.517 Unimod:95 DiffAvg: 72.06 DiffFormula: C 3 (2)H 4 N 2 DiffMono: 72.062555 Formula: C 9 (1)H 12 (2)H 4 N 4 O 1 MassAvg: 200.16 MassMono: 200.157518 Origin: K Source: artifact TermSpec: none Unimod: Unimod:95 IMID d4 IMID:2H(4) A protein modification that effectively converts an L-cysteine residue to S-(1,1,2-(2)H3)-propanamide-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: S-([1,1,2-(2)H3]-3-amino-3-oxopropyl)cysteine S-([1,1,2-(2)H3]-carbamoylethyl)-L-cysteine S-([1,1,2-(2)H3]-propanamide)-L-cysteine PSI-MOD Acrylamide d3 Propionamide:2H(3) MOD:00474 S-([1,1,2-(2)H3]-carboxamidoethyl)-L-cysteine MOD:00474 A protein modification that effectively converts an L-cysteine residue to S-(1,1,2-(2)H3)-propanamide-L-cysteine. Unimod:97#C DiffAvg: 74.06 DiffFormula: C 3 (1)H 2 (2)H 3 N 1 O 1 DiffMono: 74.055944 Formula: C 6 (1)H 7 (2)H 3 N 2 O 2 S 1 MassAvg: 177.07 MassMono: 177.065129 Origin: C Source: artifact TermSpec: none Unimod: Unimod:97 S-([1,1,2-(2)H3]-3-amino-3-oxopropyl)cysteine S-([1,1,2-(2)H3]-carbamoylethyl)-L-cysteine S-([1,1,2-(2)H3]-propanamide)-L-cysteine Acrylamide d3 Propionamide:2H(3) A protein modification that effectively converts an L-tyrosine residue to 2-amino-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Amino Tyrosine oxidation to 2-aminotyrosine MOD:00475 2-amino-L-tyrosine MOD:00475 A protein modification that effectively converts an L-tyrosine residue to 2-amino-L-tyrosine. PubMed:8839040 PubMed:9252331 Unimod:342#Y DiffAvg: 15.02 DiffFormula: H 1 N 1 DiffMono: 15.010899 Formula: C 9 H 10 N 2 O 2 MassAvg: 178.19 MassMono: 178.074228 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:342 Amino Tyrosine oxidation to 2-aminotyrosine A protein modification that effectively replaces a hydrogen atom with an galactose group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: GalRes PSI-MOD MOD:00476 monogalactosylated residue MOD:00476 A protein modification that effectively replaces a hydrogen atom with an galactose group through a glycosidic bond. PubMed:18688235 DiffAvg: 162.14 DiffFormula: C 6 H 10 O 5 DiffMono: 162.052823 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none GalRes A protein modification that effectively converts, by oxidative decarboxylation, an L-proline residue to 2-pyrrolidone with breakage of the peptide chain. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Pro->Pyrrolidinone Proline oxidation to pyrrolidinone MOD:00477 The oxidative decarboxylation of a proline residue results in breaking of the peptide chain, leaving a peptidyl-2-pyrrolidone at the C-terminus. The difference formula, derived from the result in the original citation, has been corrected from the Unimod entry. 2-pyrrolidone MOD:00477 A protein modification that effectively converts, by oxidative decarboxylation, an L-proline residue to 2-pyrrolidone with breakage of the peptide chain. PubMed:2161657 PubMed:9252331 Unimod:360#P DiffAvg: -13.02 DiffFormula: C -1 H -1 N 0 O 0 DiffMono: -13.007825 Formula: C 4 H 6 N 1 O 1 MassAvg: 84.10 MassMono: 84.044939 Origin: P Source: artifact TermSpec: none Unimod: Unimod:360 Pro->Pyrrolidinone Proline oxidation to pyrrolidinone A protein modification that effectively converts an L-proline residue to L-glutamyl semialdehyde. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Oxidation of proline to gamma-glutamyl semialdehyde gamma-glutamyl semialdehyde glutamyl 5-semialdehyde glutamyl aldehyde PSI-MOD Oxidation Oxidation or Hydroxylation MOD:00478 glutamyl semialdehyde (Pro) MOD:00478 A protein modification that effectively converts an L-proline residue to L-glutamyl semialdehyde. DeltaMass:354 PubMed:11120890 PubMed:2563380 PubMed:9252331 Unimod:35#P DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 5 H 7 N 1 O 2 MassAvg: 113.12 MassMono: 113.047678 Origin: P Source: artifact TermSpec: none Unimod: Unimod:35 Oxidation of proline to gamma-glutamyl semialdehyde gamma-glutamyl semialdehyde glutamyl 5-semialdehyde glutamyl aldehyde Oxidation Oxidation or Hydroxylation A protein modification that effectively converts an L-arginine residue to L-glutamyl semialdehyde. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Oxidation of arginine (to glutamic acid) PSI-MOD Arg->GluSA Arginine oxidation to glutamic semialdehyde MOD:00479 From DeltaMass: Average Mass: -27 Monoisotopic Mass Change:-27.06 Average Mass Change:-27.07 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. glutamyl semialdehyde (Arg) MOD:00479 A protein modification that effectively converts an L-arginine residue to L-glutamyl semialdehyde. DeltaMass:351 PubMed:11120890 PubMed:1680314 PubMed:9252331 Unimod:344#R DiffAvg: -43.07 DiffFormula: C -1 H -5 N -3 O 1 DiffMono: -43.053433 Formula: C 5 H 7 N 1 O 2 MassAvg: 113.12 MassMono: 113.047678 Origin: R Source: artifact TermSpec: none Unimod: Unimod:344 Oxidation of arginine (to glutamic acid) Arg->GluSA Arginine oxidation to glutamic semialdehyde modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: icatlight PSI-MOD Applied Biosystems cleavable ICAT(TM) light ICAT-C MOD:00480 Applied Biosystems cleavable ICAT(TM) light MOD:00480 modification from Unimod Isotopic label OMSSA:129 URL:http://www.appliedbiosystems.com/products/productdetail.cfm?prod_id=153 Unimod:105#C DiffAvg: 227.26 DiffFormula: C 10 H 17 N 3 O 3 DiffMono: 227.126991 Formula: C 13 H 22 N 4 O 4 S 1 MassAvg: 330.40 MassMono: 330.136176 Origin: C Source: artifact TermSpec: none Unimod: Unimod:105 icatlight Applied Biosystems cleavable ICAT(TM) light ICAT-C modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: icatheavy PSI-MOD Applied Biosystems cleavable ICAT(TM) heavy ICAT-C:13C(9) MOD:00481 Applied Biosystems cleavable ICAT(TM) heavy MOD:00481 modification from Unimod Isotopic label OMSSA:130 URL:http://www.appliedbiosystems.com/products/productdetail.cfm?prod_id=153 Unimod:106#C DiffAvg: 236.16 DiffFormula: (12)C 1 (13)C 9 H 17 N 3 O 3 DiffMono: 236.157185 Formula: (12)C 4 (13)C 9 H 22 N 4 O 4 S 1 MassAvg: 339.17 MassMono: 339.166370 Origin: C Source: artifact TermSpec: none Unimod: Unimod:106 icatheavy Applied Biosystems cleavable ICAT(TM) heavy ICAT-C:13C(9) A protein modification that effectively converts an L-methionine residue to N-formyl-L-methionine (not known as a natural, post-translational modification process). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0212 (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid 2-formamido-4-(methylsulfanyl)butanoic acid 2-formylamino-4-(methylthio)butanoic acid 2-formylazanyl-4-(methylsulfanyl)butanoic acid MOD_RES N-formylmethionine N-formyl-L-methionine N-formylated L-methionine NFoMet PSI-MOD MOD:00482 This entry is for the artifactual formation of N-formyl-L-methionine from methionine. For encoded N-formyl-L-methionine, use MOD:00030 [JSG]. N-formyl-L-methionine (Met) MOD:00482 A protein modification that effectively converts an L-methionine residue to N-formyl-L-methionine (not known as a natural, post-translational modification process). PubMed:11152118 PubMed:2165784 PubMed:3042771 RESID:AA0021#MET Unimod:122#M DiffAvg: 28.01 DiffFormula: C 1 H 0 N 0 O 1 S 0 DiffMono: 27.994915 Formula: C 6 H 10 N 1 O 2 S 1 MassAvg: 160.21 MassMono: 160.043225 Origin: M Source: artifact TermSpec: N-term Unimod: Unimod:122 (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid 2-formamido-4-(methylsulfanyl)butanoic acid 2-formylamino-4-(methylthio)butanoic acid 2-formylazanyl-4-(methylsulfanyl)butanoic acid MOD_RES N-formylmethionine N-formyl-L-methionine N-formylated L-methionine NFoMet A protein modification that is produced by reaction with N-ethylmaleimide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: nemc PSI-MOD N-ethylmaleimide on cysteines Nethylmaleimide MOD:00483 N-ethylmaleimide derivatized cysteine MOD:00483 A protein modification that is produced by reaction with N-ethylmaleimide. OMSSA:83 PubMed:11813307 PubMed:12777388 Unimod:108#C DiffAvg: 125.13 DiffFormula: C 6 H 7 N 1 O 2 DiffMono: 125.047678 Formula: C 9 H 12 N 2 O 3 S 1 MassAvg: 228.27 MassMono: 228.056863 Origin: C Source: artifact TermSpec: none Unimod: Unimod:108 nemc N-ethylmaleimide on cysteines Nethylmaleimide modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD OxLysBiotinRed Oxidized lysine biotinylated with biotin-LC-hydrazide, reduced MOD:00484 oxidized lysine biotinylated with biotin-LC-hydrazide, reduced MOD:00484 modification from Unimod Chemical derivative Unimod:112#K DiffAvg: 354.47 DiffFormula: C 16 H 26 N 4 O 3 S 1 DiffMono: 354.172562 Formula: C 22 H 38 N 6 O 4 S 1 MassAvg: 482.64 MassMono: 482.267525 Origin: K Source: artifact TermSpec: none Unimod: Unimod:112 OxLysBiotinRed Oxidized lysine biotinylated with biotin-LC-hydrazide, reduced modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD OxLysBiotin Oxidized lysine biotinylated with biotin-LC-hydrazide MOD:00485 oxidized lysine biotinylated with biotin-LC-hydrazide MOD:00485 modification from Unimod Chemical derivative Unimod:113#K DiffAvg: 352.45 DiffFormula: C 16 H 24 N 4 O 3 S 1 DiffMono: 352.156912 Formula: C 22 H 36 N 6 O 4 S 1 MassAvg: 480.63 MassMono: 480.251875 Origin: K Source: artifact TermSpec: none Unimod: Unimod:113 OxLysBiotin Oxidized lysine biotinylated with biotin-LC-hydrazide modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD OxProBiotinRed Oxidized proline biotinylated with biotin-LC-hydrazide, reduced MOD:00486 oxidized proline biotinylated with biotin-LC-hydrazide, reduced MOD:00486 modification from Unimod Chemical derivative Unimod:114#C DiffAvg: 371.50 DiffFormula: C 16 H 29 N 5 O 3 S 1 DiffMono: 371.199111 Formula: C 21 H 36 N 6 O 4 S 1 MassAvg: 468.62 MassMono: 468.251875 Origin: P Source: artifact TermSpec: none Unimod: Unimod:114 OxProBiotinRed Oxidized proline biotinylated with biotin-LC-hydrazide, reduced modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD OxProBiotin Oxidized Proline biotinylated with biotin-LC-hydrazide MOD:00487 oxidized proline biotinylated with biotin-LC-hydrazide MOD:00487 modification from Unimod Chemical derivative Unimod:115#C DiffAvg: 369.48 DiffFormula: C 16 H 27 N 5 O 3 S 1 DiffMono: 369.183461 Formula: C 21 H 34 N 6 O 4 S 1 MassAvg: 466.60 MassMono: 466.236225 Origin: P Source: artifact TermSpec: none Unimod: Unimod:115 OxProBiotin Oxidized Proline biotinylated with biotin-LC-hydrazide modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD OxArgBiotin Oxidized arginine biotinylated with biotin-LC-hydrazide MOD:00488 oxidized arginine biotinylated with biotin-LC-hydrazide MOD:00488 modification from Unimod Chemical derivative Unimod:116#C DiffAvg: 310.41 DiffFormula: C 15 H 22 N 2 O 3 S 1 DiffMono: 310.135114 Formula: C 21 H 34 N 6 O 4 S 1 MassAvg: 466.60 MassMono: 466.236225 Origin: R Source: artifact TermSpec: none OxArgBiotin Oxidized arginine biotinylated with biotin-LC-hydrazide modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD OxArgBiotinRed Oxidized arginine biotinylated with biotin-LC-hydrazide, reduced MOD:00489 oxidized arginine biotinylated with biotin-LC-hydrazide, reduced MOD:00489 modification from Unimod Chemical derivative Unimod:117#C DiffAvg: 312.43 DiffFormula: C 15 H 24 N 2 O 3 S 1 DiffMono: 312.150764 Formula: C 21 H 36 N 6 O 4 S 1 MassAvg: 468.62 MassMono: 468.251875 Origin: R Source: artifact TermSpec: none Unimod: Unimod:117 OxArgBiotinRed Oxidized arginine biotinylated with biotin-LC-hydrazide, reduced modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: PSI-MOD EDT-iodo-PEO-biotin EDT-iodoacetyl-PEO-biotin MOD:00490 EDT-iodo-PEO-biotin MOD:00490 modification from Unimod Chemical derivative Unimod:118 DiffAvg: 490.70 DiffFormula: C 20 H 34 N 4 O 4 S 3 DiffMono: 490.174219 Formula: none MassAvg: none MassMono: none Origin: X TermSpec: none Unimod: Unimod:118 EDT-iodo-PEO-biotin EDT-iodoacetyl-PEO-biotin modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD IBTP Thio Ether Formation - BTP Adduct MOD:00491 thio ether formation - BTP Adduct MOD:00491 modification from Unimod Chemical derivative PubMed:11861642 Unimod:119#C DiffAvg: 316.38 DiffFormula: C 22 H 21 P 1 DiffMono: 316.138087 Formula: C 25 H 26 N 1 O 1 P 1 S 1 MassAvg: 419.52 MassMono: 419.147272 Origin: C Source: artifact TermSpec: none Unimod: Unimod:119 IBTP Thio Ether Formation - BTP Adduct A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of glycylglycine, the two glycine residues left after tryptic digestion of ubiquitin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N6-(glycylglycyl)lysine N6-glycylglycyl-L-lysine glyglyk PSI-MOD GlyGly ubiquitinylation residue MOD:00492 ubiquitination signature dipeptidyl lysine MOD:00492 A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of glycylglycine, the two glycine residues left after tryptic digestion of ubiquitin. OMSSA:52 PubMed:11125103 PubMed:12612601 PubMed:12872131 RESID:AA0125#var Unimod:121#K DiffAvg: 114.10 DiffFormula: C 4 H 6 N 2 O 2 DiffMono: 114.042927 Formula: C 10 H 18 N 4 O 3 MassAvg: 242.28 MassMono: 242.137890 Origin: K Source: artifact TermSpec: none Unimod: Unimod:121 N6-(glycylglycyl)lysine N6-glycylglycyl-L-lysine glyglyk GlyGly ubiquitinylation residue A protein modification that effectively replaces a hydrogen atom with a formyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: FoRes Formylation (CHO) PSI-MOD Formyl Formylation MOD:00493 From DeltaMass: Average Mass: 28 formylated residue MOD:00493 A protein modification that effectively replaces a hydrogen atom with a formyl group. DeltaMass:0 PubMed:15799070 Unimod:122 DiffAvg: 28.01 DiffFormula: C 1 O 1 DiffMono: 27.994915 Formula: none MassAvg: none MassMono: none Origin: X TermSpec: none Unimod: Unimod:122 FoRes Formylation (CHO) Formyl Formylation modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD ICAT-H N-iodoacetyl, p-chlorobenzyl-12C6-glucamine MOD:00494 N-iodoacetyl, p-chlorobenzyl-12C6-glucamine MOD:00494 modification from Unimod Isotopic label PubMed:12185208 Unimod:123#C DiffAvg: 345.78 DiffFormula: C 15 Cl 1 H 20 N 1 O 6 S 0 DiffMono: 345.097915 Formula: C 18 Cl 1 H 25 N 2 O 7 S 1 MassAvg: 448.91 MassMono: 448.107100 Origin: C Source: artifact TermSpec: none Unimod: Unimod:123 ICAT-H N-iodoacetyl, p-chlorobenzyl-12C6-glucamine modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD ICAT-H:13C(6) N-iodoacetyl, p-chlorobenzyl-13C6-glucamine MOD:00495 N-iodoacetyl, p-chlorobenzyl-13C6-glucamine MOD:00495 modification from Unimod Isotopic label PubMed:12185208 Unimod:124#C DiffAvg: 351.12 DiffFormula: (12)C 9 (13)C 6 Cl 1 H 20 N 1 O 6 S 0 DiffMono: 351.118044 Formula: (12)C 12 (13)C 6 Cl 1 H 25 N 2 O 7 S 1 MassAvg: 454.13 MassMono: 454.127229 Origin: C Source: artifact TermSpec: none Unimod: Unimod:124 ICAT-H:13C(6) N-iodoacetyl, p-chlorobenzyl-13C6-glucamine OBSOLETE because Unimod entry 125 is merged with entry 199, remap to id: MOD:00552 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00496 reductive amination-D true MOD:00496 OBSOLETE because Unimod entry 125 is merged with entry 199, remap to id: MOD:00552 Unimod:125 DiffAvg: 32.06 DiffFormula: C 2 (2)H 4 DiffMono: 32.056407 Formula: none MassAvg: none MassMono: none Origin: K Remap: MOD:00552 Source: artifact TermSpec: none Unimod: Unimod:125 modification from Unimod [(35)S]dithiobis(succinimidyl propionate) crosslinking DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 3,3-Dithio-bis-(sulfosuccinimidyl)propionate 3-sulfanylpropanoyl Thioacyl MOD:00497 The name "thioacylation of primary amines" in Unimod was a misdescription [JSG]. 3-sulfanylpropanoyl (N-term and Lys) MOD:00497 modification from Unimod [(35)S]dithiobis(succinimidyl propionate) crosslinking PubMed:957432 Unimod:126 DiffAvg: 88.12 DiffFormula: C 3 H 4 O 1 S 1 DiffMono: 87.998286 Formula: C 9 H 16 N 2 O 2 S 1 MassAvg: 216.30 MassMono: 216.093249 Origin: K Source: artifact TermSpec: none Unimod: Unimod:126 3,3-Dithio-bis-(sulfosuccinimidyl)propionate 3-sulfanylpropanoyl Thioacyl A protein modification that effectively substitutes a hydrogen of a residue with a fluorine atom. Origin: Source: TermSpec: FRes Fluorophenylalanyl PSI-MOD Fluoro fluorophenylalanine replacement of phenylalanine MOD:00498 fluorinated residue MOD:00498 A protein modification that effectively substitutes a hydrogen of a residue with a fluorine atom. PubMed:18688235 Origin: X Source: artifact TermSpec: none FRes Fluorophenylalanyl Fluoro fluorophenylalanine replacement of phenylalanine modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 5-Iodoacetamidofluorescein (Molecular Probe, Eugene, OR) Fluorescein MOD:00499 5-iodoacetamidofluorescein MOD:00499 modification from Unimod Chemical derivative PubMed:3311742 PubMed:3578767 Unimod:128#C DiffAvg: 388.35 DiffFormula: C 22 H 14 N 1 O 6 DiffMono: 388.082112 Formula: C 25 H 19 N 2 O 7 S 1 MassAvg: 491.49 MassMono: 491.091297 Origin: C Source: artifact TermSpec: none Unimod: Unimod:128 5-Iodoacetamidofluorescein (Molecular Probe, Eugene, OR) Fluorescein A protein modification that effectively substitutes one hydrogen atom of a residue with one iodine atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: I1Res Iodination (of Histidine[C4] or Tyrosine[C3]) PSI-MOD Iodination Iodo MOD:00500 From DeltaMass: Average Mass: 126 monoiodinated residue MOD:00500 A protein modification that effectively substitutes one hydrogen atom of a residue with one iodine atom. DeltaMass:0 PubMed:15627961 PubMed:2026710 Unimod:129 DiffAvg: 125.90 DiffFormula: H -1 I 1 DiffMono: 125.896648 Formula: none MassAvg: none MassMono: none Origin: X TermSpec: none Unimod: Unimod:129 I1Res Iodination (of Histidine[C4] or Tyrosine[C3]) Iodination Iodo A protein modification that effectively substitutes two hydrogen atoms of a residue with two iodine atoms. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: TermSpec: Unimod: I2Res PSI-MOD Diiodo di-Iodination MOD:00501 From DeltaMass: Average Mass: 252 diiodinated residue MOD:00501 A protein modification that effectively substitutes two hydrogen atoms of a residue with two iodine atoms. Unimod:130 DiffAvg: 251.79 DiffFormula: H -2 I 2 DiffMono: 251.793295 Formula: none MassAvg: none MassMono: none Origin: X TermSpec: none Unimod: Unimod:130 I2Res Diiodo di-Iodination A protein modification that effectively substitutes three hydrogen atoms of a residue with three iodine atoms. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: I3Res triiodinationy PSI-MOD Triiodo tri-Iodination MOD:00502 From Unimod. In PubMed:2026710, mono- and diiodination of tyrosine are discussed, but triiodination of tyrosine is not mentioned. In PubMed:15627961, triiodothyronine (see MOD:00186) is discussed, but triiodotyrosine is not mentioned. This modification probably does not exist, and may be a confusion of "tyrosine" for "thyronine", a common error [JSG]. triiodinated residue MOD:00502 A protein modification that effectively substitutes three hydrogen atoms of a residue with three iodine atoms. OMSSA:116 PubMed:15627961 PubMed:2026710 Unimod:131 DiffAvg: 377.69 DiffFormula: H -3 I 3 DiffMono: 377.689943 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:131 I3Res triiodinationy Triiodo tri-Iodination A protein modification that effectively converts a glycine residue to N-(cis-delta 5)-tetradecaenoylglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N-(C14:1 aliphatic acyl)glycine myristoleylation (one double bond) ntermpepmyristoyeylationg PSI-MOD (cis-delta 5)-tetradecaenoyl Myristoleyl MOD:00503 N-(cis-delta 5)-tetradecaenoylglycine MOD:00503 A protein modification that effectively converts a glycine residue to N-(cis-delta 5)-tetradecaenoylglycine. OMSSA:78 PubMed:11955007 PubMed:11955008 PubMed:1326520 PubMed:1386601 PubMed:6436247 PubMed:7543369 RESID:AA0059#var Unimod:134#G DiffAvg: 208.35 DiffFormula: C 14 H 24 N 0 O 1 DiffMono: 208.182715 Formula: C 16 H 27 N 1 O 2 MassAvg: 265.40 MassMono: 265.204179 Origin: G Source: natural TermSpec: N-term Unimod: Unimod:134 N-(C14:1 aliphatic acyl)glycine myristoleylation (one double bond) ntermpepmyristoyeylationg (cis-delta 5)-tetradecaenoyl Myristoleyl A protein modification that effectively converts a glycine residue to N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N-(C14:2 aliphatic acyl)glycine myristoylation-4H (two double bonds) ntermpepmyristoyl4hg PSI-MOD (cis,cis-delta 5, delta 8)-tetradecadienoyl Myristoyl+Delta:H(-4) MOD:00504 N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine MOD:00504 A protein modification that effectively converts a glycine residue to N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine. OMSSA:79 PubMed:11955007 PubMed:11955008 PubMed:1326520 PubMed:1386601 PubMed:6436247 PubMed:7543369 RESID:AA0059#var Unimod:135#G DiffAvg: 206.33 DiffFormula: C 14 H 22 O 1 DiffMono: 206.167065 Formula: C 16 H 25 N 1 O 2 MassAvg: 263.38 MassMono: 263.188529 Origin: G Source: natural TermSpec: N-term Unimod: Unimod:135 N-(C14:2 aliphatic acyl)glycine myristoylation-4H (two double bonds) ntermpepmyristoyl4hg (cis,cis-delta 5, delta 8)-tetradecadienoyl Myristoyl+Delta:H(-4) modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Benzoyl (Bz) PSI-MOD Benzoyl labeling reagent light form (N-term & K) MOD:00505 From DeltaMass: Average Mass: 104 benzoyl labeling reagent light form (N-term and K) MOD:00505 modification from Unimod Isotopic label DeltaMass:0 PubMed:15456300 Unimod:136 DiffAvg: 104.11 DiffFormula: C 7 H 4 O 1 DiffMono: 104.026215 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:136 Benzoyl (Bz) Benzoyl labeling reagent light form (N-term & K) modification from Unimod N-linked glycosylation, Hex(5) HexNAc(2) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(5)HexNAc(2) N-linked glycan core MOD:00506 N-linked glycan core N4-glycosylated asparagine MOD:00506 modification from Unimod N-linked glycosylation, Hex(5) HexNAc(2) PubMed:111247 PubMed:1694179 PubMed:5490222 RESID:AA0151#var Unimod:137#N DiffAvg: 1217.09 DiffFormula: C 46 H 76 N 2 O 35 DiffMono: 1216.422862 Formula: C 50 H 82 N 4 O 37 GNOme: GNO:G02815KT MassAvg: 1331.20 MassMono: 1330.465790 Origin: N Source: natural TermSpec: none Unimod: Unimod:137 Hex(5)HexNAc(2) N-linked glycan core OBSOLETE because redundant, replaced by MOD:01653. Remap to MOD:01653. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: Dansyl (Dns) PSI-MOD 5-dimethylaminonaphthalene-1-sulfonyl Dansyl MOD:00507 From DeltaMass: Average Mass: 233 5-dimethylaminonaphthalene-1-sulfonyl true MOD:00507 OBSOLETE because redundant, replaced by MOD:01653. Remap to MOD:01653. DeltaMass:0 Unimod:139 DiffAvg: 233.29 DiffFormula: C 12 H 11 N 1 O 2 S 1 DiffMono: 233.051050 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:01653 Source: artifact TermSpec: none Unimod: Unimod:139 Dansyl (Dns) 5-dimethylaminonaphthalene-1-sulfonyl Dansyl OBSOLETE because this is an ion type and is not a biological or chemical modification to a polypeptide, can be handled by PSI-MS CV term, MS:1001229 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD ISD a-series (C-Term) a-type-ion MOD:00508 Virtual Modification for MS/MS of a-type ions, by decarboxylation of C-terminus as reaction inside the mass spectrometer. ISD a-series (C-Term) true MOD:00508 OBSOLETE because this is an ion type and is not a biological or chemical modification to a polypeptide, can be handled by PSI-MS CV term, MS:1001229 PubMed:14588022 Unimod:140 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: C-term Unimod: Unimod:140 ISD a-series (C-Term) a-type-ion modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Amidine amidination of lysines or N-terminal amines with methyl acetimidate MOD:00509 amidination of lysines or N-terminal amines with methyl acetimidate MOD:00509 modification from Unimod Chemical derivative PubMed:12643539 PubMed:6273432 Unimod:141 DiffAvg: 41.05 DiffFormula: C 2 H 3 N 1 DiffMono: 41.026549 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:141 Amidine amidination of lysines or N-terminal amines with methyl acetimidate modification from Unimod N-linked glycosylation, dHex HexNAc DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: dHexHexNAcN PSI-MOD HexNAc(1)dHex(1) HexNAc1dHex1 MOD:00510 HexNAc1dHex1 N4-glycosylated asparagine MOD:00510 modification from Unimod N-linked glycosylation, dHex HexNAc OMSSA:183 PubMed:111247 PubMed:1694179 PubMed:5490222 RESID:AA0151#var Unimod:142 DiffAvg: 349.34 DiffFormula: C 14 H 23 N 1 O 9 DiffMono: 349.137281 Formula: C 18 H 29 N 3 O 11 GNOme: GNO:G00194GV MassAvg: 463.44 MassMono: 463.180209 Origin: N Source: natural TermSpec: none Unimod: Unimod:142 dHexHexNAcN HexNAc(1)dHex(1) HexNAc1dHex1 modification from Unimod N-linked glycosylation, HexNAc(2) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HexNAc(2) HexNAc2 MOD:00511 HexNAc2 N4-glycosylated asparagine MOD:00511 modification from Unimod N-linked glycosylation, HexNAc(2) PubMed:111247 PubMed:1694179 PubMed:5490222 RESID:AA0151#var Unimod:143 DiffAvg: 406.39 DiffFormula: C 16 H 26 N 2 O 10 DiffMono: 406.158745 Formula: C 20 H 32 N 4 O 12 GNOme: GNO:G27391WQ MassAvg: 520.49 MassMono: 520.201672 Origin: N Source: natural TermSpec: none Unimod: Unimod:143 HexNAc(2) HexNAc2 modification from Unimod N-linked glycosylation, Hex3 DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(3) Hex3 MOD:00512 Hex3 N4-glycosylated asparagine MOD:00512 modification from Unimod N-linked glycosylation, Hex3 PubMed:111247 PubMed:1694179 PubMed:5490222 RESID:AA0151#var Unimod:144 DiffAvg: 486.42 DiffFormula: C 18 H 30 O 15 DiffMono: 486.158470 Formula: C 22 H 36 N 2 O 17 GNOme: GNO:G39365VM MassAvg: 600.53 MassMono: 600.201398 Origin: N Source: natural TermSpec: none Unimod: Unimod:144 Hex(3) Hex3 modification from Unimod N-linked glycosylation, dHex(2) HexNAc DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HexNAc(1)dHex(2) HexNAc1dHex2 MOD:00513 HexNAc1dHex2 N4-glycosylated asparagine MOD:00513 modification from Unimod N-linked glycosylation, dHex(2) HexNAc PubMed:111247 PubMed:1694179 PubMed:5490222 RESID:AA0151#var Unimod:145 DiffAvg: 495.48 DiffFormula: C 20 H 33 N 1 O 13 DiffMono: 495.195190 Formula: C 24 H 39 N 3 O 15 GNOme: GNO:G74392IM MassAvg: 609.58 MassMono: 609.238118 Origin: N Source: natural TermSpec: none Unimod: Unimod:145 HexNAc(1)dHex(2) HexNAc1dHex2 modification from Unimod N-linked glycosylation, dHex Hex HexNAc DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(1)dHex(1) Hex1HexNAc1dHex1 MOD:00514 Hex1HexNAc1dHex1 N4-glycosylated asparagine MOD:00514 modification from Unimod N-linked glycosylation, dHex Hex HexNAc PubMed:111247 PubMed:1694179 PubMed:5490222 RESID:AA0151#var Unimod:146 DiffAvg: 511.48 DiffFormula: C 20 H 33 N 1 O 14 DiffMono: 511.190105 Formula: C 24 H 39 N 3 O 16 GNOme: GNO:G54129SE MassAvg: 625.58 MassMono: 625.233032 Origin: N Source: natural TermSpec: none Unimod: Unimod:146 Hex(1)HexNAc(1)dHex(1) Hex1HexNAc1dHex1 modification from Unimod N-linked glycosylation, dHex HexNAc(2) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HexNAc(2)dHex(1) HexNAc2dHex1 MOD:00515 HexNAc2dHex1 N4-glycosylated asparagine MOD:00515 modification from Unimod N-linked glycosylation, dHex HexNAc(2) PubMed:111247 PubMed:1694179 PubMed:5490222 RESID:AA0151#var Unimod:147 DiffAvg: 552.53 DiffFormula: C 22 H 36 N 2 O 14 DiffMono: 552.216654 Formula: C 26 H 42 N 4 O 16 GNOme: GNO:G06042JP MassAvg: 666.63 MassMono: 666.259581 Origin: N Source: natural TermSpec: none Unimod: Unimod:147 HexNAc(2)dHex(1) HexNAc2dHex1 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(2) Hex1HexNAc2 MOD:00516 Hex1HexNAc2 N4-glycosylated asparagine MOD:00516 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:148 DiffAvg: 568.53 DiffFormula: C 22 H 36 N 2 O 15 DiffMono: 568.211568 Formula: C 26 H 42 N 4 O 17 GNOme: GNO:G58001LT MassAvg: 682.63 MassMono: 682.254496 Origin: N Source: natural TermSpec: none Unimod: Unimod:148 Hex(1)HexNAc(2) Hex1HexNAc2 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: NeuAc-Hex-HexNAc PSI-MOD Hex(1)HexNAc(1)NeuAc(1) Hex1HexNAc1NeuAc1 MOD:00517 From DeltaMass: Average Mass: 657 Hex1HexNAc1NeuAc1 glycosylated residue MOD:00517 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. DeltaMass:0 Unimod:149 DiffAvg: 657.60 DiffFormula: C 25 H 41 N 2 O 18 DiffMono: 657.235437 Formula: none GNOme: GNO:G17015OC MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none NeuAc-Hex-HexNAc Hex(1)HexNAc(1)NeuAc(1) Hex1HexNAc1NeuAc1 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HexNAc(2)dHex(2) HexNAc2dHex2 MOD:00518 HexNAc2dHex2 N4-glycosylated asparagine MOD:00518 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:150 DiffAvg: 698.67 DiffFormula: C 28 H 46 N 2 O 18 DiffMono: 698.274563 Formula: C 32 H 52 N 4 O 20 GNOme: GNO:G90423UY MassAvg: 812.78 MassMono: 812.317490 Origin: N Source: natural TermSpec: none Unimod: Unimod:150 HexNAc(2)dHex(2) HexNAc2dHex2 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(2)Pent(1) Hex1HexNAc2Pent1 MOD:00519 Hex1HexNAc2Pent1 N4-glycosylated asparagine MOD:00519 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:151 DiffAvg: 700.64 DiffFormula: C 27 H 44 N 2 O 19 DiffMono: 700.253827 Formula: C 31 H 50 N 4 O 21 GNOme: GNO:G54968WM MassAvg: 814.75 MassMono: 814.296755 Origin: N Source: natural TermSpec: none Unimod: Unimod:151 Hex(1)HexNAc(2)Pent(1) Hex1HexNAc2Pent1 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(2)dHex(1) Hex1HexNAc2dHex1 MOD:00520 Hex1HexNAc2dHex1 N4-glycosylated asparagine MOD:00520 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:152 DiffAvg: 714.67 DiffFormula: C 28 H 46 N 2 O 19 DiffMono: 714.269477 Formula: C 32 H 52 N 4 O 21 GNOme: GNO:G94583DZ MassAvg: 828.77 MassMono: 828.312405 Origin: N Source: natural TermSpec: none Unimod: Unimod:152 Hex(1)HexNAc(2)dHex(1) Hex1HexNAc2dHex1 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(2)HexNAc(2) Hex2HexNAc2 MOD:00521 Hex2HexNAc2 N4-glycosylated asparagine MOD:00521 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:153 DiffAvg: 730.67 DiffFormula: C 28 H 46 N 2 O 20 DiffMono: 730.264392 Formula: C 32 H 52 N 4 O 22 GNOme: GNO:G53434XO MassAvg: 844.77 MassMono: 844.307319 Origin: N Source: natural TermSpec: none Unimod: Unimod:153 Hex(2)HexNAc(2) Hex2HexNAc2 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(3)HexNAc(1)Pent(1) Hex3HexNAc1Pent1 MOD:00522 Hex3HexNAc1Pent1 N4-glycosylated asparagine MOD:00522 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:154 DiffAvg: 821.73 DiffFormula: C 31 H 51 N 1 O 24 DiffMono: 821.280102 Formula: C 35 H 57 N 3 O 26 GNOme: GNO:G64686LL MassAvg: 935.84 MassMono: 935.323029 Origin: N Source: natural TermSpec: none Unimod: Unimod:154 Hex(3)HexNAc(1)Pent(1) Hex3HexNAc1Pent1 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(2)dHex(1)Pent(1) Hex1HexNAc2dHex1Pent1 MOD:00523 Hex1HexNAc2dHex1Pent1 N4-glycosylated asparagine MOD:00523 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:155 DiffAvg: 846.79 DiffFormula: C 33 H 54 N 2 O 23 DiffMono: 846.311736 Formula: C 35 H 57 N 3 O 26 GNOme: GNO:G84825UQ MassAvg: 960.89 MassMono: 960.354663 Origin: N Source: natural TermSpec: none Unimod: Unimod:155 Hex(1)HexNAc(2)dHex(1)Pent(1) Hex1HexNAc2dHex1Pent1 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(2)dHex(2) Hex1HexNAc2dHex2 MOD:00524 Hex1HexNAc2dHex2 N4-glycosylated asparagine MOD:00524 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:156 DiffAvg: 860.81 DiffFormula: C 34 H 56 N 2 O 23 DiffMono: 860.327386 Formula: C 38 H 62 N 4 O 25 GNOme: GNO:G05460KC MassAvg: 974.92 MassMono: 974.370313 Origin: N Source: natural TermSpec: none Unimod: Unimod:156 Hex(1)HexNAc(2)dHex(2) Hex1HexNAc2dHex2 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(2)HexNAc(2)Pent(1) Hex2HexNAc2Pent1 MOD:00525 Hex2HexNAc2Pent1 N4-glycosylated asparagine MOD:00525 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:157 DiffAvg: 862.79 DiffFormula: C 33 H 54 N 2 O 24 DiffMono: 862.306651 Formula: C 37 H 60 N 4 O 26 GNOme: GNO:G18999EB MassAvg: 976.89 MassMono: 976.349578 Origin: N Source: natural TermSpec: none Unimod: Unimod:157 Hex(2)HexNAc(2)Pent(1) Hex2HexNAc2Pent1 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(2)HexNAc(2)dHex(1) Hex2HexNAc2dHex1 MOD:00526 Hex2HexNAc2dHex1 N4-glycosylated asparagine MOD:00526 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:158 DiffAvg: 876.81 DiffFormula: C 34 H 56 N 2 O 24 DiffMono: 876.322301 Formula: C 38 H 62 N 4 O 26 GNOme: GNO:G93579XB MassAvg: 990.92 MassMono: 990.365228 Origin: N Source: natural TermSpec: none Unimod: Unimod:158 Hex(2)HexNAc(2)dHex(1) Hex2HexNAc2dHex1 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (Hex)3-HexNAc-HexNAc PSI-MOD Hex(3)HexNAc(2) Hex3HexNAc2 MOD:00527 From DeltaMass: Average Mass: 893 Hex3HexNAc2 N4-glycosylated asparagine MOD:00527 modification from Unimod N-linked glycosylation DeltaMass:0 RESID:AA0151#var Unimod:159 DiffAvg: 892.81 DiffFormula: C 34 H 56 N 2 O 25 DiffMono: 892.317215 Formula: C 38 H 62 N 4 O 27 GNOme: GNO:G28681TP MassAvg: 1006.92 MassMono: 1006.360143 Origin: N Source: natural TermSpec: none Unimod: Unimod:159 (Hex)3-HexNAc-HexNAc Hex(3)HexNAc(2) Hex3HexNAc2 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(1)NeuAc(2) Hex1HexNAc1NeuAc2 MOD:00528 Hex1HexNAc1NeuAc2 glycosylated residue MOD:00528 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. Unimod:160 DiffAvg: 947.85 DiffFormula: C 36 H 57 N 3 O 26 DiffMono: 947.323029 Formula: none GNOme: GNO:G23729WG MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:160 Hex(1)HexNAc(1)NeuAc(2) Hex1HexNAc1NeuAc2 modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(3)HexNAc(2)P(1) Hex3HexNAc2P1 MOD:00529 Hex3HexNAc2P1 N4-glycosylated asparagine MOD:00529 modification from Unimod N-linked glycosylation RESID:AA0151#var Unimod:161 DiffAvg: 972.79 DiffFormula: C 34 H 57 N 2 O 28 P 1 DiffMono: 972.283546 Formula: C 38 H 63 N 4 O 30 P 1 GNOme: GNO:G88520YF MassAvg: 1086.89 MassMono: 1086.326473 Origin: N Source: natural TermSpec: none Unimod: Unimod:161 Hex(3)HexNAc(2)P(1) Hex3HexNAc2P1 A protein modification that effectively converts an L-methionine residue to L-selenomethionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Se(S)Met semetm PSI-MOD Delta:S(-1)Se(1) Selenium replaces sulphur MOD:00530 L-selenomethionine MOD:00530 A protein modification that effectively converts an L-methionine residue to L-selenomethionine. OMSSA:113 PubMed:12148805 Unimod:162#M DiffAvg: 46.91 DiffFormula: C 0 H 0 N 0 S -1 Se 1 DiffMono: 47.944450 Formula: C 5 H 9 N 1 O 1 Se 1 MassAvg: 178.10 MassMono: 178.984935 Origin: M Source: artifact TermSpec: none Unimod: Unimod:162 Se(S)Met semetm Delta:S(-1)Se(1) Selenium replaces sulphur A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O as the result of having been deglycosylated in (18)O water. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:H(1)O(-1)18O(1) glycosylated asparagine 18O labeling MOD:00531 (18)O labeled deglycosylated asparagine MOD:00531 A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O as the result of having been deglycosylated in (18)O water. PubMed:14435542 Unimod:170 DiffAvg: 2.99 DiffFormula: H -1 N -1 (18)O 1 DiffMono: 2.988262 Formula: C 4 H 5 N 1 (16)O 2 (18)O 1 MassAvg: 117.03 MassMono: 117.031189 Origin: N Source: artifact TermSpec: none Unimod: Unimod:170 Delta:H(1)O(-1)18O(1) glycosylated asparagine 18O labeling modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD NBS:13C(6) Shimadzu NBS-13C MOD:00532 Shimadzu 13CNBS MOD:00532 modification from Unimod Chemical derivative PubMed:12845591 Unimod:171 DiffAvg: 159.01 DiffFormula: (13)C 6 H 3 N 1 O 2 S 1 DiffMono: 159.008578 Formula: (12)C 11 (13)C 6 H 13 N 3 O 3 S 1 MassAvg: 345.09 MassMono: 345.087891 Origin: W Source: artifact TermSpec: none Unimod: Unimod:171 NBS:13C(6) Shimadzu NBS-13C modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD NBS Shimadzu NBS-12C MOD:00533 Shimadzu 12CNBS MOD:00533 modification from Unimod Chemical derivative PubMed:12845591 Unimod:172 DiffAvg: 152.99 DiffFormula: (12)C 6 H 3 N 1 O 2 S 1 DiffMono: 152.988449 Formula: (12)C 17 H 13 N 3 O 3 S 1 MassAvg: 339.07 MassMono: 339.067762 Origin: W Source: artifact TermSpec: none Unimod: Unimod:172 NBS Shimadzu NBS-12C modification from Unimod Post-translational DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD BHT Michael addition of BHT quinone methide to Cysteine and Lysine MOD:00534 Butylated Hydroxytoluene adduct. Michael addition of BHT quinone methide to cysteine and lysine MOD:00534 modification from Unimod Post-translational PubMed:9448752 Unimod:176 DiffAvg: 218.34 DiffFormula: C 15 H 22 O 1 DiffMono: 218.167065 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:176 BHT Michael addition of BHT quinone methide to Cysteine and Lysine modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD DAET phosphorylation to amine thiol MOD:00535 DAET = 2-(dimethylamino)ethanethiol. The phosphorylation to amine is the beta elimination of phosphate and Michael addition of 2-(dimethylamino)ethanethiol to the site. phosphorylation to amine thiol MOD:00535 modification from Unimod Chemical derivative PubMed:12216740 Unimod:178 DiffAvg: 87.18 DiffFormula: C 4 H 9 N 1 O -1 S 1 DiffMono: 87.050656 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:178 DAET phosphorylation to amine thiol OBSOLETE because Unimod 179 merged with Unimod 447 remap to ??? a protein modification that replaces an L-serine residue with an L-alanine residue DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Ser_Ala PSI-MOD MOD:00536 L-serine to L-alanine replacement true MOD:00536 OBSOLETE because Unimod 179 merged with Unimod 447 remap to ??? a protein modification that replaces an L-serine residue with an L-alanine residue Unimod:179 DiffAvg: -16.00 DiffFormula: O -1 DiffMono: -15.994915 Formula: none MassAvg: none MassMono: none Origin: S Source: artifact TermSpec: none Unimod: Unimod:179 Ser_Ala A protein modification that effectively converts an L-threonine residue to L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Thr(Ala) PSI-MOD Thr->Ala Thr->Ala substitution MOD:00537 This could represent either an engineered replacement or a chemical modification. L-alanine residue (Thr) MOD:00537 A protein modification that effectively converts an L-threonine residue to L-alanine. Unimod:659 DiffAvg: -30.03 DiffFormula: C -1 H -2 O -1 DiffMono: -30.010565 Formula: C 3 H 5 N 1 O 1 MassAvg: 71.08 MassMono: 71.037114 Origin: T Source: none TermSpec: none Unimod: Unimod:659 Thr(Ala) Thr->Ala Thr->Ala substitution Modified amino acid residues groups into isobaric sets at particular mass resolution cut-offs. PSI-MOD MOD:00538 protein modification categorized by isobaric sets MOD:00538 Modified amino acid residues groups into isobaric sets at particular mass resolution cut-offs. PubMed:18688235 OBSOLETE because Unimod 179 merged wth Unimod 447 remap to ??? modification from Unimod O-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:00539 threonine reduced to aminobutynate true MOD:00539 OBSOLETE because Unimod 179 merged wth Unimod 447 remap to ??? modification from Unimod O-linked glycosylation Unimod:182 DiffAvg: -17.01 DiffFormula: H -1 O -1 DiffMono: -17.002740 Formula: none MassAvg: none MassMono: none Origin: T Source: artifact TermSpec: none Unimod: Unimod:182 A protein modification that effectively converts a residue containing common isotopes to a 9x(13)C labeled residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(9) Silac label Label:13C(9) MOD:00540 9x(13)C labeled residue MOD:00540 A protein modification that effectively converts a residue containing common isotopes to a 9x(13)C labeled residue. PubMed:12716131 Unimod:184 DiffAvg: 9.03 DiffFormula: (12)C -9 (13)C 9 DiffMono: 9.030194 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:184 13C(9) Silac label Label:13C(9) A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-phosphotyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD C13 label (Phosphotyrosine) Label:13C(9)+Phospho MOD:00541 9x(13)C labeled L-phosphotyrosine MOD:00541 A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-phosphotyrosine. PubMed:12716131 Unimod:185 DiffAvg: 89.00 DiffFormula: (12)C -9 (13)C 9 H 1 O 3 P 1 DiffMono: 88.996524 Formula: (13)C 9 H 10 N 1 O 5 P 1 MassAvg: 252.06 MassMono: 252.059853 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:185 C13 label (Phosphotyrosine) Label:13C(9)+Phospho modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HPG Hydroxyphenylglyoxal arginine MOD:00542 hydroxyphenylglyoxal arginine MOD:00542 modification from Unimod Chemical derivative PubMed:11698400 PubMed:11914093 Unimod:186 DiffAvg: 132.12 DiffFormula: C 8 H 4 O 2 DiffMono: 132.021129 Formula: C 14 H 16 N 4 O 3 MassAvg: 288.31 MassMono: 288.122240 Origin: R Source: artifact TermSpec: none Unimod: Unimod:186 HPG Hydroxyphenylglyoxal arginine modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 2HPG bis(hydroxphenylglyoxal) arginine MOD:00543 OH-PGO and PGO react with arginine at a stoichiometry of 2:1 [Unimod]. bis(hydroxyphenylglyoxal) arginine MOD:00543 modification from Unimod Chemical derivative PubMed:11698400 Unimod:187 DiffAvg: 282.25 DiffFormula: C 16 H 10 O 5 DiffMono: 282.052823 Formula: C 22 H 22 N 4 O 6 MassAvg: 438.44 MassMono: 438.153934 Origin: R Source: artifact TermSpec: none Unimod: Unimod:187 2HPG bis(hydroxphenylglyoxal) arginine A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C labeled residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(6) Silac label Label:13C(6) MOD:00544 6x(13)C labeled residue MOD:00544 A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C labeled residue. PubMed:12716131 Unimod:188 DiffAvg: 6.02 DiffFormula: (12)C -6 (13)C 6 DiffMono: 6.020129 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:188 13C(6) Silac label Label:13C(6) OBSOLETE because redundant with MOD:00927. Remap to MOD:00927. Origin: Remap: Source: TermSpec: PSI-MOD MOD:00545 deuterated dimethyl labeling (D) true MOD:00545 OBSOLETE because redundant with MOD:00927. Remap to MOD:00927. PubMed:14670044 Origin: X Remap: MOD:00927 Source: artifact TermSpec: N-term A protein modification that effectively substitutes two (18)O atom for the two (16)O atoms of an alpha-carboxyl (1-carboxyl) group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: ctermpepdio18 PSI-MOD Label:18O(2) O18 label at both C-terminal oxygens MOD:00546 (18)O label at both C-terminal oxygens MOD:00546 A protein modification that effectively substitutes two (18)O atom for the two (16)O atoms of an alpha-carboxyl (1-carboxyl) group. OMSSA:88 PubMed:11467524 Unimod:193 DiffAvg: 4.01 DiffFormula: (16)O -2 (18)O 2 DiffMono: 4.008493 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: C-term Unimod: Unimod:193 ctermpepdio18 Label:18O(2) O18 label at both C-terminal oxygens modification from Unimod Chemical derivative used for amino acid analysis DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate AccQTag MOD:00547 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate MOD:00547 modification from Unimod Chemical derivative used for amino acid analysis PubMed:14997490 Unimod:194 DiffAvg: 170.17 DiffFormula: C 10 H 6 N 2 O 1 DiffMono: 170.048013 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:194 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate AccQTag modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD APTA-d0 QAT MOD:00548 Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride [JSG]. APTA MOD:00548 modification from Unimod Chemical derivative PubMed:15283597 Unimod:195 DiffAvg: 171.26 DiffFormula: C 9 H 19 N 2 O 1 DiffMono: 171.149738 Formula: C 12 H 24 N 3 O 2 S 1 MassAvg: 274.40 MassMono: 274.158923 Origin: C Source: artifact TermSpec: none Unimod: Unimod:195 APTA-d0 QAT modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD (3-acrylamidopropyl)trimethylammonium APTA d3 QAT:2H(3) MOD:00549 Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride (difference formula correct) [JSG]. APTA d3 MOD:00549 modification from Unimod Isotopic label PubMed:15283597 Unimod:196 DiffAvg: 174.17 DiffFormula: C 9 (1)H 16 (2)H 3 N 2 O 1 DiffMono: 174.168568 Formula: C 12 (1)H 21 (2)H 3 N 3 O 2 S 1 MassAvg: 277.18 MassMono: 277.177753 Origin: C Source: artifact TermSpec: none Unimod: Unimod:196 (3-acrylamidopropyl)trimethylammonium APTA d3 QAT:2H(3) modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD EAPTA d0 EQAT MOD:00550 EAPTA d0 MOD:00550 modification from Unimod Chemical derivative Unimod:197 DiffAvg: 184.28 DiffFormula: C 10 H 20 N 2 O 1 DiffMono: 184.157563 Formula: C 13 H 25 N 3 O 2 S 1 MassAvg: 287.42 MassMono: 287.166748 Origin: C Source: artifact TermSpec: none Unimod: Unimod:197 EAPTA d0 EQAT modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD EAPTA d5 EQAT:2H(5) MOD:00551 EAPTA d5 MOD:00551 modification from Unimod Isotopic label Unimod:198 DiffAvg: 189.19 DiffFormula: C 10 (1)H 15 (2)H 5 N 2 O 1 DiffMono: 189.188947 Formula: C 13 (1)H 20 (2)H 5 N 3 O 2 S 1 MassAvg: 292.20 MassMono: 292.198132 Origin: C Source: artifact TermSpec: none Unimod: Unimod:198 EAPTA d5 EQAT:2H(5) A protein modification that effectively converts a residue containing common isotopes to a 4x(2)H labeled dimethylated residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD DiMethyl-CHD2 Dimethyl:2H(4) MOD:00552 Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. 4x(2)H labeled dimethylated residue MOD:00552 A protein modification that effectively converts a residue containing common isotopes to a 4x(2)H labeled dimethylated residue. PubMed:14670044 Unimod:199 DiffAvg: 32.06 DiffFormula: C 2 (2)H 4 DiffMono: 32.056407 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:199 DiMethyl-CHD2 Dimethyl:2H(4) A protein modification that effectively substitutes a (2-sulfanylethyl)sulfanyl (or thioethylthiol) group for a hydroxy group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 1,2-ethanedithiol (EDT) PSI-MOD EDT Ethanedithiol MOD:00553 From DeltaMass: Average Mass: 93; supposed to be derivatization of serine and threonine. 1,2-ethanedithiol modified residue MOD:00553 A protein modification that effectively substitutes a (2-sulfanylethyl)sulfanyl (or thioethylthiol) group for a hydroxy group. DeltaMass:0 PubMed:11507762 Unimod:200 DiffAvg: 76.18 DiffFormula: C 2 H 4 O -1 S 2 DiffMono: 75.980528 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:200 1,2-ethanedithiol (EDT) EDT Ethanedithiol OBSOLETE because Unimod entry 202 was merged with entry 195, remap to MOD:00548. modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00554 APTA-d0 with no neutral loss true MOD:00554 OBSOLETE because Unimod entry 202 was merged with entry 195, remap to MOD:00548. modification from Unimod Chemical derivative Unimod:202 DiffAvg: 170.26 DiffFormula: C 9 H 18 N 2 O 1 DiffMono: 170.141913 Formula: none MassAvg: none MassMono: none Origin: C Remap: MOD:00548 Source: artifact TermSpec: none Unimod: Unimod:202 OBSOLETE because Unimod entry 202 was merged with entry 195, remap to MOD:00548. modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00555 APTA-d0 with quaternary amine loss true MOD:00555 OBSOLETE because Unimod entry 202 was merged with entry 195, remap to MOD:00548. modification from Unimod Chemical derivative Unimod:203 DiffAvg: 170.26 DiffFormula: C 9 H 18 N 2 O 1 DiffMono: 170.141913 Formula: none MassAvg: none MassMono: none Origin: C Remap: MOD:00548 Source: artifact TermSpec: none Unimod: Unimod:203 OBSOLETE because this modification not supported by any literature that I can find[PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acrolein addition +94 Delta:H(6)C(6)O(1) MOD:00556 acrolein addition +94 true MOD:00556 OBSOLETE because this modification not supported by any literature that I can find[PMT] Unimod:205 DiffAvg: 94.11 DiffFormula: C 6 H 6 O 1 DiffMono: 94.041865 Formula: C 12 H 18 N 2 O 2 MassAvg: 222.29 MassMono: 222.136828 Origin: K Source: artifact TermSpec: none Unimod: Unimod:205 Acrolein addition +94 Delta:H(6)C(6)O(1) OBSOLETE because this modification not supported by the papers listed or any other that I can find[PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acrolein addition +56 Delta:H(4)C(3)O(1) MOD:00557 acrolein addition +56 true MOD:00557 OBSOLETE because this modification not supported by the papers listed or any other that I can find[PMT] PubMed:10825247 PubMed:15541752 Unimod:206 DiffAvg: 56.06 DiffFormula: C 3 H 4 O 1 DiffMono: 56.026215 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:206 Acrolein addition +56 Delta:H(4)C(3)O(1) OBSOLETE because this modification not supported by any literature that I can find[PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acrolein addition +38 Delta:H(2)C(3) MOD:00558 acrolein addition +38 true MOD:00558 OBSOLETE because this modification not supported by any literature that I can find[PMT] Unimod:207 DiffAvg: 38.05 DiffFormula: C 3 H 2 DiffMono: 38.015650 Formula: C 9 H 14 N 2 O 1 MassAvg: 166.22 MassMono: 166.110613 Origin: K Source: artifact TermSpec: none Unimod: Unimod:207 Acrolein addition +38 Delta:H(2)C(3) OBSOLETE because this modification not supported by any literature that I can find[PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acrolein addition +76 Delta:H(4)C(6) MOD:00559 acrolein addition +76 true MOD:00559 OBSOLETE because this modification not supported by any literature that I can find[PMT] Unimod:208 DiffAvg: 76.10 DiffFormula: C 6 H 4 DiffMono: 76.031300 Formula: C 12 H 16 N 2 O 1 MassAvg: 204.27 MassMono: 204.126263 Origin: K Source: artifact TermSpec: none Unimod: Unimod:208 Acrolein addition +76 Delta:H(4)C(6) OBSOLETE because this modification not supported by any literature that I can find[PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acrolein addition +112 Delta:H(8)C(6)O(2) MOD:00560 acrolein addition +112 true MOD:00560 OBSOLETE because this modification not supported by any literature that I can find[PMT] Unimod:209 DiffAvg: 112.13 DiffFormula: C 6 H 8 O 2 DiffMono: 112.052429 Formula: C 12 H 20 N 2 O 3 MassAvg: 240.30 MassMono: 240.147393 Origin: K Source: artifact TermSpec: none Unimod: Unimod:209 Acrolein addition +112 Delta:H(8)C(6)O(2) modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD N-ethyl iodoacetamide-d0 NEIAA MOD:00561 N-ethyl iodoacetamide- MOD:00561 modification from Unimod Isotopic label PubMed:12766232 Unimod:211 DiffAvg: 85.11 DiffFormula: C 4 H 7 N 1 O 1 DiffMono: 85.052764 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:211 N-ethyl iodoacetamide-d0 NEIAA modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD N-ethyl iodoacetamide-d5 NEIAA:2H(5) MOD:00562 N-ethyl iodoacetamide-d5 MOD:00562 modification from Unimod Isotopic label PubMed:12766232 Unimod:212 DiffAvg: 90.08 DiffFormula: C 4 (1)H 2 (2)H 5 N 1 O 1 DiffMono: 90.084148 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:212 N-ethyl iodoacetamide-d5 NEIAA:2H(5) A protein modification that effectively replaces a hydrogen atom with an N-acetylaminogalactose group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: GalNAcRes PSI-MOD HexNAc MOD:00563 mono-N-acetylaminogalactosylated residue MOD:00563 A protein modification that effectively replaces a hydrogen atom with an N-acetylaminogalactose group through a glycosidic bond. PubMed:18688235 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none GalNAcRes HexNAc Modification from Unimod Isotopic label. The Unimod term was extracted when it had not been approved. OBSOLETE because redundant to MOD:01505. Remap to MOD:01505, or one of the child terms MOD:01493 or MOD:01497. Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Representative mass and accurate mass for 116 & 117 iTRAQ4plex MOD:00564 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry true MOD:00564 Modification from Unimod Isotopic label. The Unimod term was extracted when it had not been approved. OBSOLETE because redundant to MOD:01505. Remap to MOD:01505, or one of the child terms MOD:01493 or MOD:01497. URL:http://docs.appliedbiosystems.com/pebiodocs/04351918.pdf Unimod:214 Origin: X Remap: MOD:01505 Source: artifact TermSpec: none Unimod: Unimod:214 Representative mass and accurate mass for 116 & 117 iTRAQ4plex modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Deamidated Deamidation MOD:00565 Conversion of glycosylated asparagine residues upon deglycosylation with PGNase F in H2O. CAUTION - the difference formula appears to be based on a partial structure [JSG]. deglycosylated asparagine MOD:00565 modification from Unimod N-linked glycosylation Unimod:7#N DiffAvg: 0.98 DiffFormula: H -1 N -1 O 1 DiffMono: 0.984016 Formula: C 4 H 5 N 1 O 3 MassAvg: 115.09 MassMono: 115.026943 Origin: N Source: artifact TermSpec: none Unimod: Unimod:7 Deamidated Deamidation modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD IGBP Light IDBEST tag for quantitation MOD:00566 "IDBEST tag for quantitation, http://www.targetdiscovery.com/index.php?topic=prod.idbe" label cysteine with IGBP reagent MOD:00566 modification from Unimod Chemical derivative Unimod:243 DiffAvg: 297.15 DiffFormula: Br 1 C 12 H 13 N 2 O 2 DiffMono: 296.016040 Formula: Br 1 C 15 H 18 N 3 O 3 S 1 MassAvg: 400.29 MassMono: 399.025225 Origin: C Source: artifact TermSpec: none Unimod: Unimod:243 IGBP Light IDBEST tag for quantitation OBSOLETE because Unimod entry 244 is redundant with Unimod 348. Remap to MOD:00775. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:00567 histidine oxidation to asparagine true MOD:00567 OBSOLETE because Unimod entry 244 is redundant with Unimod 348. Remap to MOD:00775. ChEBI:29956 PubMed:15736973 PubMed:5681232 PubMed:6692818 PubMed:9789001 RESID:AA0003 Unimod:244 DiffAvg: -23.04 DiffFormula: C -2 H -1 N -1 O 1 DiffMono: -23.015984 Formula: none MassAvg: none MassMono: none Origin: H Source: artifact TermSpec: none Unimod: Unimod:244 OBSOLETE because Unimod entry 245 is redundant with Unimod 349. Remap to MOD:00776 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00568 histidine oxidation to aspartic acid true MOD:00568 OBSOLETE because Unimod entry 245 is redundant with Unimod 349. Remap to MOD:00776 PubMed:1097438 PubMed:339692 PubMed:4399050 PubMed:5764436 PubMed:6692818 PubMed:8089117 PubMed:9521123 PubMed:9582379 Unimod:245 DiffAvg: -22.05 DiffFormula: C -2 H -2 N -2 O 2 DiffMono: -22.031969 Formula: none MassAvg: none MassMono: none Origin: H Remap: MOD:00776 Source: artifact TermSpec: none Unimod: Unimod:245 Natural or modified residues that are isobaric at a resolution below 0.000001 Da. PSI-MOD MOD:00569 residues isobaric at a resolution below 0.000001 Da MOD:00569 Natural or modified residues that are isobaric at a resolution below 0.000001 Da. PubMed:18688235 Natural or modified residues with a mass of 71.037114 Da. PSI-MOD MOD:00570 residues isobaric at 71.037114 Da MOD:00570 Natural or modified residues with a mass of 71.037114 Da. PubMed:18688235 A modification that effectively oxygenates C5 of an L-proline residue to form a 2-pyrrolidone-5-carboxylic acid, pyroglutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PyrGlu(Pro) pyroglutamicp PSI-MOD Pro->pyro-Glu Pyroglutamic MOD:00571 The review article PubMed:9252331 does not provide an original citation for this modification [JSG]. 2-pyrrolidone-5-carboxylic acid (Pro) MOD:00571 A modification that effectively oxygenates C5 of an L-proline residue to form a 2-pyrrolidone-5-carboxylic acid, pyroglutamic acid. OMSSA:111 PubMed:9252331 Unimod:359 DiffAvg: 13.98 DiffFormula: H -2 O 1 DiffMono: 13.979265 Formula: C 5 H 6 N 1 O 2 MassAvg: 112.11 MassMono: 112.039853 Origin: P Source: artifact TermSpec: none Unimod: Unimod:359 PyrGlu(Pro) pyroglutamicp Pro->pyro-Glu Pyroglutamic modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Argbiotinhydrazide oxidized Arginine biotinylated with biotin hydrazide MOD:00572 oxidized arginine biotinylated with biotin hydrazide MOD:00572 modification from Unimod Chemical derivative PubMed:15174056 PubMed:15828771 Unimod:343 DiffAvg: 199.27 DiffFormula: C 9 H 13 N 1 O 2 S 1 DiffMono: 199.066700 Formula: C 15 H 25 N 5 O 3 S 1 MassAvg: 355.46 MassMono: 355.167811 Origin: R Source: artifact TermSpec: none Unimod: Unimod:343 Argbiotinhydrazide oxidized Arginine biotinylated with biotin hydrazide modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Lysbiotinhydrazide oxidized Lysine biotinylated with biotin hydrazide MOD:00573 "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" oxidized lysine biotinylated with biotin hydrazide MOD:00573 modification from Unimod Chemical derivative PubMed:15174056 Unimod:353 DiffAvg: 241.31 DiffFormula: C 10 H 15 N 3 O 2 S 1 DiffMono: 241.088498 Formula: C 16 H 27 N 5 O 3 S 1 MassAvg: 369.48 MassMono: 369.183461 Origin: K Source: artifact TermSpec: none Unimod: Unimod:353 Lysbiotinhydrazide oxidized Lysine biotinylated with biotin hydrazide modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD oxidized proline biotinylated with biotin hydrazide probiotinhydrazide MOD:00574 "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" oxidized proline biotinylated with biotin hydrazide MOD:00574 modification from Unimod Chemical derivative PubMed:15174056 Unimod:357 DiffAvg: 258.34 DiffFormula: C 10 H 18 N 4 O 2 S 1 DiffMono: 258.115047 Formula: C 15 H 25 N 5 O 3 S 1 MassAvg: 355.46 MassMono: 355.167811 Origin: P Source: artifact TermSpec: none Unimod: Unimod:357 oxidized proline biotinylated with biotin hydrazide probiotinhydrazide modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Thrbiotinhydrazide oxidized Threonine biotinylated with biotin hydrazide MOD:00575 "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB" oxidized threonine biotinylated with biotin hydrazide MOD:00575 modification from Unimod Chemical derivative PubMed:15174056 Unimod:361 DiffAvg: 240.32 DiffFormula: C 10 H 16 N 4 O 1 S 1 DiffMono: 240.104482 Formula: C 14 H 23 N 5 O 3 S 1 MassAvg: 341.43 MassMono: 341.152161 Origin: T Source: artifact TermSpec: none Unimod: Unimod:361 Thrbiotinhydrazide oxidized Threonine biotinylated with biotin hydrazide modification from Unimod Other DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Crotonaldehyde MOD:00576 crotonylated residue MOD:00576 modification from Unimod Other PubMed:11283024 PubMed:25907603 Unimod:253 DiffAvg: 70.09 DiffFormula: C 4 H 6 O 1 DiffMono: 70.041865 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:253 Crotonaldehyde Crotonaldehyde modification occurs as a Schiff base in the presence of pentalysine DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acetaldehyde +26 Delta:H(2)C(2) MOD:00577 acetaldehyde crosslinked penta-L-lysine MOD:00577 modification occurs as a Schiff base in the presence of pentalysine PubMed:7744761 Unimod:254 DiffAvg: 26.04 DiffFormula: C 2 H 2 DiffMono: 26.015650 Formula: C 8 H 14 N 2 O 1 MassAvg: 666.91 MassMono: 666.490465 Origin: K, K, K, K, K Source: artifact TermSpec: none Unimod: Unimod:254 Acetaldehyde +26 Delta:H(2)C(2) OBSOLETE because this modification not supported by any literature that I can find [PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acetaldehyde +28 Delta:H(4)C(2) MOD:00578 acetaldehyde +28 true MOD:00578 OBSOLETE because this modification not supported by any literature that I can find [PMT] Unimod:255 DiffAvg: 28.05 DiffFormula: C 2 H 4 DiffMono: 28.031300 Formula: C MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:255 Acetaldehyde +28 Delta:H(4)C(2) OBSOLETE because not supported by the linked literature [PMT]. modification from Unimod Other DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:H(4)C(3) Propionaldehyde +40 MOD:00579 propionaldehyde +40 true MOD:00579 OBSOLETE because not supported by the linked literature [PMT]. modification from Unimod Other Unimod:256 DiffAvg: 40.06 DiffFormula: C 3 H 4 DiffMono: 40.031300 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:256 Delta:H(4)C(3) Propionaldehyde +40 OBSOLETE because entry removed from Unimod. Remap potentially to MOD:00579 propionaldehyde +40 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00580 propionaldehyde +42 true MOD:00580 OBSOLETE because entry removed from Unimod. Remap potentially to MOD:00579 propionaldehyde +40 Unimod:257 DiffAvg: 42.08 DiffFormula: C 3 H 6 DiffMono: 42.046950 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00579 Source: artifact TermSpec: none Unimod: Unimod:257 A protein modification that effectively substitutes one (18)O atom for one (16)O atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: ctermpepo18 PSI-MOD Label:18O(1) O18 Labeling MOD:00581 (18)O monosubstituted residue MOD:00581 A protein modification that effectively substitutes one (18)O atom for one (16)O atom. OMSSA:87 PubMed:11467524 Unimod:258 DiffAvg: 2.00 DiffFormula: (16)O -1 (18)O 1 DiffMono: 2.004246 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: C-term Unimod: Unimod:258 ctermpepo18 Label:18O(1) O18 Labeling A protein modification that effectively converts an L-lysine residue to 6x(13)C,2x(15)N labeled L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: lys-13C615N2 PSI-MOD 13C(6) 15N(2) Silac label Label:13C(6)15N(2) MOD:00582 6x(13)C,2x(15)N labeled L-lysine MOD:00582 A protein modification that effectively converts an L-lysine residue to 6x(13)C,2x(15)N labeled L-lysine. OMSSA:181 PubMed:12716131 Unimod:259 DiffAvg: 8.01 DiffFormula: (12)C -6 (13)C 6 (14)N -2 (15)N 2 DiffMono: 8.014199 Formula: (13)C 6 H 12 (15)N 2 O 1 MassAvg: 136.11 MassMono: 136.109162 Origin: K Source: artifact TermSpec: none Unimod: Unimod:259 lys-13C615N2 13C(6) 15N(2) Silac label Label:13C(6)15N(2) A protein modification that effectively replaces a hydrogen atom with a thiophosphono group (H2PO2S, 'thiophosphate'). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Thiophospho Thiophosphorylation MOD:00583 thiophosphorylated residue MOD:00583 A protein modification that effectively replaces a hydrogen atom with a thiophosphono group (H2PO2S, 'thiophosphate'). PubMed:12110917 Unimod:260 DiffAvg: 96.04 DiffFormula: H 1 O 2 P 1 S 1 DiffMono: 95.943487 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:260 Thiophospho Thiophosphorylation A protein modification produced by formation of an adduct with 4-sulfophenyl isothiocyanate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 4-sulfophenyl isothiocyanate SPITC MOD:00584 4-sulfophenyl isothiocyanate derivatized residue MOD:00584 A protein modification produced by formation of an adduct with 4-sulfophenyl isothiocyanate. PubMed:14689565 PubMed:14745769 PubMed:16526082 Unimod:261 DiffAvg: 215.24 DiffFormula: C 7 H 5 N 1 O 3 S 2 DiffMono: 214.971085 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:261 4-sulfophenyl isothiocyanate SPITC A protein modification that effectively substitutes three (2)H deuterium atoms for three (1)H protium atoms. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: D(H)3Res PSI-MOD Label:2H(3) Trideuteration MOD:00585 deuterium trisubstituted residue MOD:00585 A protein modification that effectively substitutes three (2)H deuterium atoms for three (1)H protium atoms. Unimod:262 DiffAvg: 3.02 DiffFormula: (1)H -3 (2)H 3 DiffMono: 3.018830 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:262 D(H)3Res Label:2H(3) Trideuteration modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD PET phosphorylation to pyridyl thiol MOD:00586 pyridyl thiol modified residue MOD:00586 modification from Unimod Chemical derivative Unimod:264 DiffAvg: 121.20 DiffFormula: C 7 H 7 N 1 O -1 S 1 DiffMono: 121.035006 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:264 PET phosphorylation to pyridyl thiol A protein modification that effectively converts an L-arginine residue to 6x(13)C, 4x(15)N labeled L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: arg-13c6-15n4 PSI-MOD 13C(6) 15N(4) Silac label Label:13C(6)15N(4) MOD:00587 6x(13)C,4x(15)N labeled L-arginine MOD:00587 A protein modification that effectively converts an L-arginine residue to 6x(13)C, 4x(15)N labeled L-arginine. OMSSA:137 PubMed:12716131 Unimod:267 DiffAvg: 10.01 DiffFormula: (12)C -6 (13)C 6 (14)N -4 (15)N 4 DiffMono: 10.008269 Formula: (13)C 6 H 12 (15)N 4 O 1 MassAvg: 166.11 MassMono: 166.109380 Origin: R Source: artifact TermSpec: none Unimod: Unimod:267 arg-13c6-15n4 13C(6) 15N(4) Silac label Label:13C(6)15N(4) A protein modification that effectively converts an L-valine residue to 5x(13)C,1x(15)N labeled L-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(5) 15N(1) Silac label Label:13C(5)15N(1) MOD:00588 5x(13)C,1x(15)N labeled L-valine MOD:00588 A protein modification that effectively converts an L-valine residue to 5x(13)C,1x(15)N labeled L-valine. PubMed:12771378 Unimod:268#V DiffAvg: 6.01 DiffFormula: (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono: 6.013809 Formula: (13)C 5 H 9 (15)N 1 O 1 MassAvg: 105.08 MassMono: 105.082223 Origin: V Source: artifact TermSpec: none Unimod: Unimod:268 13C(5) 15N(1) Silac label Label:13C(5)15N(1) A protein modification that effectively converts an L-phenylalanine residue to (13)C,(15)N labeled L-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(9) 15N(1) Silac label Label:13C(9)15N(1) MOD:00589 9x(13)C,1x(15)N labeled L-phenylalanine MOD:00589 A protein modification that effectively converts an L-phenylalanine residue to (13)C,(15)N labeled L-phenylalanine. PubMed:12771378 Unimod:269 DiffAvg: 10.03 DiffFormula: (12)C -9 (13)C 9 (14)N -1 (15)N 1 DiffMono: 10.027228 Formula: (13)C 9 H 9 (15)N 1 O 1 MassAvg: 157.10 MassMono: 157.095642 Origin: F Source: artifact TermSpec: none Unimod: Unimod:269 13C(9) 15N(1) Silac label Label:13C(9)15N(1) OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne nucleophilic addtion to cytopiloyne MOD:00590 nucleophilic addtion to cytopiloyne true MOD:00590 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative PubMed:15549660 Unimod:270 DiffAvg: 362.38 DiffFormula: C 19 H 22 O 7 DiffMono: 362.136553 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:270 Cytopiloyne nucleophilic addtion to cytopiloyne OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O MOD:00591 nucleophilic addition to cytopiloyne+H2O true MOD:00591 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative PubMed:15549660 Unimod:271 DiffAvg: 380.39 DiffFormula: C 19 H 24 O 8 DiffMono: 380.147118 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:271 Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD CAF sulfonation of N-terminus MOD:00592 sulfonation of N-terminal MOD:00592 modification from Unimod Chemical derivative PubMed:12705581 PubMed:15732931 PubMed:16046801 Unimod:272 DiffAvg: 136.12 DiffFormula: C 3 H 4 O 4 S 1 DiffMono: 135.983030 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:272 CAF sulfonation of N-terminus OBSOLETE because removed from Unimod. modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Xlink:SSD covalent modification of lysine by cross-linking reagent MOD:00593 J. Prot. Chem. 2, 263-277, 1983 covalent modification of lysine by omega-maleimido alkanoyl N-hydroxysuccinimido esters true MOD:00593 OBSOLETE because removed from Unimod. modification from Unimod Chemical derivative Unimod:273 DiffAvg: 253.25 DiffFormula: C 12 H 15 N 1 O 5 DiffMono: 253.095023 Formula: C 18 H 27 N 3 O 6 MassAvg: 381.43 MassMono: 381.189986 Origin: K Source: artifact TermSpec: none Unimod: Unimod:273 Xlink:SSD covalent modification of lysine by cross-linking reagent Natural or modified resiues with a mass of 113.047678 Da. PSI-MOD MOD:00594 residues isobaric at 113.047678 Da MOD:00594 Natural or modified resiues with a mass of 113.047678 Da. PubMed:18688235 A protein modification that effectively replaces a hydrogen atom with an manose group through a glycosidic bond DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: ManRes PSI-MOD MOD:00595 monomannosylated residue MOD:00595 A protein modification that effectively replaces a hydrogen atom with an manose group through a glycosidic bond PubMed:18688235 DiffAvg: 162.14 DiffFormula: C 6 H 10 O 5 DiffMono: 162.052823 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none ManRes A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: AEBSF PSI-MOD AEBS Aminoethylbenzenesulfonylation MOD:00596 From DeltaMass: Average Mass: 183 Average Mass Change:183 References:We have found that AEBSF modifies many proteins by covalent attachment, preferentially on Tyr, and to a lesser extent on Lys, His, and the amino-terminus. These modifications were identified by electrospray MS of the proteins (adds 183 Da per AEBS-group) and by peptide mapping and MS/MS. All the proteins we examined were modified after 24 hrs. at 4 C with 1 mM AEBSF in TRIS, pH 8.0. The reaction is 10-20x slower at pH 7; however AEBSF is quite stable in aqueous solution and the extent of to which the protein is modified continues to increase for several days. We have seen the addition of 10 or more AEBS-groups to proteins after prolonged storage. We found no equivalent modification from PMSF, probably because it degrades so quickly. We no longer use AEBSF, and urge caution to those who do. To address the problem, Boehringer Mannheim (now Roche Molecular Biochemicals) introduced Pefabloc PLUS which includes an additional component to compete for these side reactions. In our limited experience with Pefabloc PLUS, it reduces the +183 modifications, but does not always eliminate them. As a result, we prefer PMSF, despite its own set of drawbacks. We have never found PMSF-induced modification of proteins (except trypsin), probably due to its short half-life in aqeous solution. 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue MOD:00596 A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS. DeltaMass:235 PubMed:8597590 Unimod:276 DiffAvg: 183.23 DiffFormula: C 8 H 9 N 1 O 2 S 1 DiffMono: 183.035400 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:276 AEBSF AEBS Aminoethylbenzenesulfonylation OBSOLETE because Unimod entry 277 redundant with Unimod 39. Remap to MOD:00110. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00597 methyl methanethiosulfonate true MOD:00597 OBSOLETE because Unimod entry 277 redundant with Unimod 39. Remap to MOD:00110. Unimod:277 DiffAvg: 46.09 DiffFormula: C 1 H 2 S 1 DiffMono: 45.987721 Formula: none MassAvg: none MassMono: none Origin: C Remap: MOD:00110 Source: artifact TermSpec: none Unimod: Unimod:277 A protein modification that effectively converts an L-cysteine residue to S-(2-hydroxyethyl)cysteine DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Ethanolation of Cys Ethanolyl MOD:00598 This modification of cysteine is produced by the reagent iodoethanol with triethylphosphine [JSG]. S-(2-hydroxyethyl)cysteine MOD:00598 A protein modification that effectively converts an L-cysteine residue to S-(2-hydroxyethyl)cysteine PubMed:15351294 Unimod:278 DiffAvg: 44.05 DiffFormula: C 2 H 4 O 1 DiffMono: 44.026215 Formula: C 5 H 9 N 1 O 2 S 1 MassAvg: 147.19 MassMono: 147.035400 Origin: C Source: artifact TermSpec: none Unimod: Unimod:278 Ethanolation of Cys Ethanolyl A protein modification that effectively replaces one hydrogen atom with one methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Me1Res PSI-MOD Methyl Methylation MOD:00599 monomethylated residue MOD:00599 A protein modification that effectively replaces one hydrogen atom with one methyl group. PubMed:11875433 Unimod:34 DiffAvg: 14.03 DiffFormula: C 1 H 2 DiffMono: 14.015650 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:34 Me1Res Methyl Methylation A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-ethyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Ethyl PSI-MOD Ethyl Ethylation MOD:00600 From DeltaMass: Average Mass: 28 with no citation. The Unimod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation. For dimethylated residues, see MOD:00429 and its children [JSG]. L-glutamic acid 5-ethyl ester MOD:00600 A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-ethyl ester. DeltaMass:0 PubMed:9629898 Unimod:280#E DiffAvg: 28.05 DiffFormula: C 2 H 4 DiffMono: 28.031300 Formula: C 7 H 11 N 1 O 3 MassAvg: 157.17 MassMono: 157.073893 Origin: E Source: artifact TermSpec: none Unimod: Unimod:280 Ethyl Ethyl Ethylation A protein modification that effectively produces an heterocyclic amino acid with a covalent bond between the side chain and either its alpha amino or 1-carboxyl group, possibly breaking the peptide chain. CycRes PSI-MOD MOD:00601 cyclized residue MOD:00601 A protein modification that effectively produces an heterocyclic amino acid with a covalent bond between the side chain and either its alpha amino or 1-carboxyl group, possibly breaking the peptide chain. PubMed:18688235 CycRes A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with an methyl group. NMeRes PSI-MOD MOD:00602 N-methylated residue MOD:00602 A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with an methyl group. PubMed:18688235 NMeRes OBSOLETE because Unimod entry 283 is redundant with Unimod 280. Remap to MOD:00600 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00603 N-ethylation true MOD:00603 OBSOLETE because Unimod entry 283 is redundant with Unimod 280. Remap to MOD:00600 Unimod:283 DiffAvg: 28.05 DiffFormula: C 2 H 4 DiffMono: 28.031300 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00600 Source: artifact TermSpec: N-term Unimod: Unimod:283 A protein modification that effectively converts an L-lysine residue to 2x(2)H labeled monomethylated L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Deuterium Methylation of Lysine Methyl:2H(2) MOD:00604 2x(2)H monomethylated L-lysine MOD:00604 A protein modification that effectively converts an L-lysine residue to 2x(2)H labeled monomethylated L-lysine. PubMed:15525938 Unimod:284 DiffAvg: 16.03 DiffFormula: C 1 (2)H 2 DiffMono: 16.028204 Formula: C 7 (1)H 12 (2)H 2 N 2 O 1 MassAvg: 144.12 MassMono: 144.123167 Origin: K Source: artifact TermSpec: none Unimod: Unimod:284 Deuterium Methylation of Lysine Methyl:2H(2) modification from Unimod Chemical derivative, C-Terminal/Glutamate/Aspartate sulfonation DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Light Sulfanilic Acid (SA) C12 SulfanilicAcid MOD:00605 Sulfanilic Acid (SA), light C12 MOD:00605 modification from Unimod Chemical derivative, C-Terminal/Glutamate/Aspartate sulfonation Unimod:285 DiffAvg: 155.00 DiffFormula: (12)C 6 H 5 N 1 O 2 S 1 DiffMono: 155.004099 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: C-term Unimod: Unimod:285 Light Sulfanilic Acid (SA) C12 SulfanilicAcid modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Heavy Sulfanilic Acid (SA) C13 SulfanilicAcid:13C(6) MOD:00606 Sulfanilic Acid (SA), heavy C13 MOD:00606 modification from Unimod Chemical derivative PubMed:9254591 Unimod:286 DiffAvg: 161.02 DiffFormula: (13)C 6 H 5 N 1 O 2 S 1 DiffMono: 161.024228 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: C-term Unimod: Unimod:286 Heavy Sulfanilic Acid (SA) C13 SulfanilicAcid:13C(6) modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Trp->Oxolactone Tryptophan oxidation to oxolactone MOD:00607 Unimod name, formula, and terminal specification corrected. Formula corresponded to uncleaved intermediate [JSG]. dioxoindolealanine lactone MOD:00607 modification from Unimod Chemical derivative PubMed:7949339 Unimod:288 DiffAvg: 30.99 DiffFormula: H -1 O 2 DiffMono: 30.982004 Formula: C 11 H 9 N 2 O 3 MassAvg: 217.20 MassMono: 217.061317 Origin: W Source: artifact TermSpec: C-term Unimod: Unimod:288 Trp->Oxolactone Tryptophan oxidation to oxolactone modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Biotin polyethyleneoxide amine Biotin-PEO-Amine MOD:00608 biotin polyethyleneoxide amine MOD:00608 modification from Unimod Chemical derivative Unimod:289 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:289 Biotin polyethyleneoxide amine Biotin-PEO-Amine modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Biotin-HPDP Pierce EZ-Link Biotin-HPDP MOD:00609 Pierce EZ-Link Biotin-HPDP modified L-cysteine MOD:00609 modification from Unimod Chemical derivative Unimod:290 DiffAvg: 428.61 DiffFormula: C 19 H 32 N 4 O 3 S 2 DiffMono: 428.191583 Formula: C 22 H 37 N 5 O 4 S 3 MassAvg: 531.75 MassMono: 531.200768 Origin: C Source: artifact TermSpec: none Unimod: Unimod:290 Biotin-HPDP Pierce EZ-Link Biotin-HPDP modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:Hg(1) Mercury Mercaptan MOD:00610 cysteinyl mercury MOD:00610 modification from Unimod Chemical derivative PubMed:10695144 Unimod:291 DiffAvg: 200.59 DiffFormula: Hg 1 DiffMono: 201.970643 Formula: C 3 H 5 Hg 1 N 1 O 1 S 1 MassAvg: 303.73 MassMono: 304.979828 Origin: C Source: artifact TermSpec: none Unimod: Unimod:291 Delta:Hg(1) Mercury Mercaptan A protein modification that is produced by reaction of iodouridine monophosphate with a residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cross-link of (Iodo)-uracil MP with W,F,Y IodoU-AMP MOD:00611 iodouridine monophosphate derivatized residue MOD:00611 A protein modification that is produced by reaction of iodouridine monophosphate with a residue. PubMed:11112526 PubMed:11567090 PubMed:6540775 Unimod:292 DiffAvg: 322.17 DiffFormula: C 9 H 11 N 2 O 9 P 1 DiffMono: 322.020217 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:292 Cross-link of (Iodo)-uracil MP with W,F,Y IodoU-AMP A protein modification that is produced by derivatization of a residue with 3,3-dithiobis[sulfosuccinimidyl propanoate], DTSSP, or with Pierce EZ-Link Sulfo-NHS-SS-Biotin reagent, sulfosuccinimidyl 3-[(2-[biotinamido]ethyl)disulfanyl]propanoate, followed by reduction with dithiothreitol and then reaction with iodoacetamide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 3-(carbamidomethylthio)propanoyl CAMthiopropanoyl MOD:00612 3-(carboxamidomethylthio)propanoylated residue MOD:00612 A protein modification that is produced by derivatization of a residue with 3,3-dithiobis[sulfosuccinimidyl propanoate], DTSSP, or with Pierce EZ-Link Sulfo-NHS-SS-Biotin reagent, sulfosuccinimidyl 3-[(2-[biotinamido]ethyl)disulfanyl]propanoate, followed by reduction with dithiothreitol and then reaction with iodoacetamide. PubMed:15121203 Unimod:293 DiffAvg: 145.18 DiffFormula: C 5 H 7 N 1 O 2 S 1 DiffMono: 145.019749 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:293 3-(carbamidomethylthio)propanoyl CAMthiopropanoyl modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD IED-Biotin biotinoyl-iodoacetyl-ethylenediamine MOD:00613 biotinoyl-iodoacetyl-ethylenediamine MOD:00613 modification from Unimod Chemical derivative PubMed:10906242 Unimod:294 DiffAvg: 326.42 DiffFormula: C 14 H 22 N 4 O 3 S 1 DiffMono: 326.141262 Formula: C 17 H 27 N 5 O 4 S 2 MassAvg: 429.55 MassMono: 429.150446 Origin: C Source: artifact TermSpec: none Unimod: Unimod:294 IED-Biotin biotinoyl-iodoacetyl-ethylenediamine A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a fucose (6-deoxy-D-galactose) group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Fuc PSI-MOD Fucose dHex MOD:00614 fucosylated residue MOD:00614 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a fucose (6-deoxy-D-galactose) group through a glycosidic bond. PubMed:11344537 PubMed:15189151 Unimod:295 DiffAvg: 146.14 DiffFormula: C 6 H 10 O 4 DiffMono: 146.057909 Formula: none GNOme: GNO:G49112ZN MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:295 Fuc Fucose dHex OBSOLETE because entry Unimod:261 site N-term R was abandoned. Remap to MOD:00584 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00615 4-sulfophenyl isothiocyante modification to N-term R true MOD:00615 OBSOLETE because entry Unimod:261 site N-term R was abandoned. Remap to MOD:00584 PubMed:14689565 Unimod:261 DiffAvg: 215.24 DiffFormula: C 7 H 5 N 1 O 3 S 2 DiffMono: 214.971085 Formula: none MassAvg: none MassMono: none Origin: R Remap: MOD:00584 Source: artifact TermSpec: N-term Unimod: Unimod:261 Natural or modified residues that are isobaric at a resolution below 0.1 Da. PSI-MOD MOD:00616 residues isobaric at a resolution below 0.1 Da MOD:00616 Natural or modified residues that are isobaric at a resolution below 0.1 Da. PubMed:18688235 A protein modification that effectively converts a residue containing common isotopes to a 3x(2)H labeled residue methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: ctermpeptrideuteromethyl PSI-MOD Methyl:2H(3) deuterated methyl ester MOD:00617 3x(2)H residue methyl ester MOD:00617 A protein modification that effectively converts a residue containing common isotopes to a 3x(2)H labeled residue methyl ester. OMSSA:21 Unimod:298 DiffAvg: 17.03 DiffFormula: C 1 (1)H -1 (2)H 3 DiffMono: 17.034480 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: C-term Unimod: Unimod:298 ctermpeptrideuteromethyl Methyl:2H(3) deuterated methyl ester modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Carboxy Carboxylation MOD:00618 There is no literature citation for this Unimod entry [JSG]. tryptophan carboxylation MOD:00618 modification from Unimod Chemical derivative Unimod:299#W DiffAvg: 44.01 DiffFormula: C 1 O 2 DiffMono: 43.989829 Formula: C 12 H 10 N 2 O 3 MassAvg: 230.22 MassMono: 230.069142 Origin: W Source: artifact TermSpec: none Unimod: Unimod:299 Carboxy Carboxylation OBSOLETE because entry 300 is redundant with Unimod 6 remap to MOD:01328 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00619 hydroxylethanone true MOD:00619 OBSOLETE because entry 300 is redundant with Unimod 6 remap to MOD:01328 Unimod:300 DiffAvg: 58.04 DiffFormula: C 2 H 2 O 2 DiffMono: 58.005479 Formula: none MassAvg: none MassMono: none Origin: W Remap: MOD:01328 Source: artifact TermSpec: none Unimod: Unimod:300 modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Bromobimane Monobromobimane derivative MOD:00620 1-(bromomethyl)-2,6,7-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione, C 10 H 11 Br 1 N 2 O 2. cysteine monobromobimane derivative MOD:00620 modification from Unimod Chemical derivative PubMed:7856876 Unimod:301 DiffAvg: 190.20 DiffFormula: C 10 H 10 N 2 O 2 DiffMono: 190.074228 Formula: C 13 H 15 N 3 O 3 S 1 MassAvg: 293.34 MassMono: 293.083412 Origin: C Source: artifact TermSpec: none Unimod: Unimod:301 Bromobimane Monobromobimane derivative modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Menadione Menadione quinone derivative MOD:00621 menadione quinone derivative MOD:00621 modification from Unimod Chemical derivative PubMed:15939799 Unimod:302 DiffAvg: 170.17 DiffFormula: C 11 H 6 O 2 DiffMono: 170.036779 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:302 Menadione Menadione quinone derivative modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Beta mercaptoethanol adduct PSI-MOD Cysteine mercaptoethanol DeStreak MOD:00622 From DeltaMass: Average Mass: 76 Average Mass Change:76 PubMed:8019414. cysteine mercaptoethanol MOD:00622 modification from Unimod Chemical derivative DeltaMass:80 PubMed:12442261 Unimod:303 DiffAvg: 76.11 DiffFormula: C 2 H 4 O 1 S 1 DiffMono: 75.998286 Formula: C 5 H 9 N 1 O 2 S 2 MassAvg: 179.25 MassMono: 179.007471 Origin: C Source: artifact TermSpec: none Unimod: Unimod:303 Beta mercaptoethanol adduct Cysteine mercaptoethanol DeStreak modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Fucosylated biantennary (-2 galactose) dHex(1)Hex(3)HexNAc(4) MOD:00623 fucosylated biantennary (-2 galactose) N4-glycosylated asparagine MOD:00623 modification from Unimod N-linked glycosylation Unimod:305 DiffAvg: 1443.33 DiffFormula: C 56 H 90 N 4 O 39 DiffMono: 1442.518219 Formula: C 60 H 96 N 6 O 41 GNOme: GNO:G25987BV MassAvg: 1557.43 MassMono: 1556.561147 Origin: N Source: natural TermSpec: none Unimod: Unimod:305 Fucosylated biantennary (-2 galactose) dHex(1)Hex(3)HexNAc(4) Natural or modified residues with a mass of 113.0-113.1 Da. PSI-MOD MOD:00624 residues isobaric at 113.0-113.1 Da MOD:00624 Natural or modified residues with a mass of 113.0-113.1 Da. PubMed:18688235 modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Nmethylmaleimide MOD:00625 N-methylmaleimide derivatized residue MOD:00625 modification from Unimod Chemical derivative Unimod:314 DiffAvg: 111.10 DiffFormula: C 5 H 5 N 1 O 2 DiffMono: 111.032028 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:314 Nmethylmaleimide Nmethylmaleimide modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD FTC fluorescein-5-thiosemicarbazide MOD:00626 fluorescein-5-thiosemicarbazide modified residue MOD:00626 modification from Unimod Chemical derivative PubMed:2883911 Unimod:478 DiffAvg: 421.43 DiffFormula: C 21 H 15 N 3 O 5 S 1 DiffMono: 421.073242 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:478 FTC fluorescein-5-thiosemicarbazide modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-6-(2,5-dimethylpyrrolidin-1-yl)hexanoic acid 6-(2,5-dimethylpyrrolidin-1-yl)norleucine PSI-MOD 2,5-dimethypyrrole DimethylpyrroleAdduct MOD:00627 There is no citation for this Unimod entry. Add PubMed:7981420, correct spelling [JSG]. 2,5-dimethylpyrrole lysine from 2,5-hexanedione adduct MOD:00627 modification from Unimod Chemical derivative Unimod:316 DiffAvg: 78.11 DiffFormula: C 6 H 6 DiffMono: 78.046950 Formula: C 12 H 18 N 2 O 1 MassAvg: 206.29 MassMono: 206.141913 Origin: K Source: artifact TermSpec: none Unimod: Unimod:316 (2S)-2-amino-6-(2,5-dimethylpyrrolidin-1-yl)hexanoic acid 6-(2,5-dimethylpyrrolidin-1-yl)norleucine 2,5-dimethypyrrole DimethylpyrroleAdduct a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with two hexose sugar groups through glycosidic bonds DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00628 Hex2 MOD:00628 a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with two hexose sugar groups through glycosidic bonds PubMed:18688235 DiffAvg: 324.28 DiffFormula: C 12 H 20 O 10 DiffMono: 324.105647 Formula: none GNOme: GNO:G90627TW MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:H(2)C(5) MDA adduct +62 MOD:00629 Usually major adduct formed from malondialdehyde (MDA) with the amino group of lysine residues [UniProt]. MDA adduct +62 MOD:00629 modification from Unimod Chemical derivative Unimod:318 DiffAvg: 62.07 DiffFormula: C 5 H 2 DiffMono: 62.015650 Formula: C 11 H 14 N 2 O 1 MassAvg: 190.25 MassMono: 190.110613 Origin: K Source: artifact TermSpec: none Unimod: Unimod:318 Delta:H(2)C(5) MDA adduct +62 modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:H(2)C(3)O(1) MDA adduct +54 MOD:00630 This is not a legitimate ontological entry and will become obsolete when the children are reassigned [JSG] C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine. MOD:00630 modification from Unimod Chemical derivative PubMed:9328283 Unimod:319 DiffAvg: 54.05 DiffFormula: C 3 H 2 O 1 DiffMono: 54.010565 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:319 Delta:H(2)C(3)O(1) MDA adduct +54 modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Nethylmaleimide+water Nethylmaleimidehydrolysis MOD:00631 N-ethylmaeimide adduct + H20 (a mixture of isobaric products) [JSG]. hydrolyzed N-ethylmaleimide adduct MOD:00631 modification from Unimod Chemical derivative Unimod:320 DiffAvg: 143.14 DiffFormula: C 6 H 9 N 1 O 3 DiffMono: 143.058243 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:320 Nethylmaleimide+water Nethylmaleimidehydrolysis OBSOLETE because this chemical derivative modification from Unimod 321 is deprecated. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:00632 N-succinimide true MOD:00632 OBSOLETE because this chemical derivative modification from Unimod 321 is deprecated. Unimod:321 DiffAvg: -17.01 DiffFormula: H -1 O -1 DiffMono: -17.002740 Formula: none MassAvg: none MassMono: none Origin: N Source: artifact TermSpec: none Unimod: Unimod:321 modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: bis-((N-iodoacetyl)piperazinyl)sulfonerhodamine PSI-MOD Xlink:B10621 bis-N-I-sulfonerahodamine MOD:00633 Invitrogen B-10621, a red fluorescent cross-linking reagent (only link to Cys is indicated) [Unimod]. bis-N-I-sulfonerahodamine MOD:00633 modification from Unimod Chemical derivative Unimod:323 DiffAvg: 713.57 DiffFormula: C 31 H 30 I 1 N 4 O 6 S 1 DiffMono: 713.093078 Formula: C 34 H 35 I 1 N 5 O 7 S 2 MassAvg: 816.71 MassMono: 816.102263 Origin: C Source: artifact TermSpec: none Unimod: Unimod:323 bis-((N-iodoacetyl)piperazinyl)sulfonerhodamine Xlink:B10621 bis-N-I-sulfonerahodamine modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD DTBP dimethyl 3,3'-dithiobispropionimidate MOD:00634 Pierce reagent, needs sites for N, Q, R, K, and N-term [JSG]. dimethyl 3,3'-dithiobispropionimidate MOD:00634 modification from Unimod Chemical derivative PubMed:770170 Unimod:324 DiffAvg: 123.60 DiffFormula: C 3 Cl 1 H 6 N 1 S 1 DiffMono: 122.990948 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:324 DTBP dimethyl 3,3'-dithiobispropionimidate modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 10-ethoxyphosphinyl-N-(biotinamidopentyl)decanamide FP-Biotin MOD:00635 10-fluoroethoxyphosphinyl-N-(biotinamidopentyl)decanamide MOD:00635 FP-Biotin modification from Unimod Chemical derivative PubMed:10611275 Unimod:325 DiffAvg: 572.75 DiffFormula: C 27 H 49 N 4 O 5 P 1 S 1 DiffMono: 572.316128 Formula: C 30 H 54 N 5 O 7 P 1 S 1 MassAvg: 659.82 MassMono: 659.348157 Origin: S Source: artifact TermSpec: none Unimod: Unimod:325 10-ethoxyphosphinyl-N-(biotinamidopentyl)decanamide A protein modification that effectively converts an L-serine residue to S-ethylcysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:H(4)C(2)O(-1)S(1) S-Ethylcystine from Serine MOD:00636 Modification from Unimod. Phosphoserine is converted to dehydroalanine then by Michael addition of ethanethiol to S-ethylcysteine. Needs parent and sibling for S-ethyl-cysteine. S-ethylcysteine (Ser) MOD:00636 A protein modification that effectively converts an L-serine residue to S-ethylcysteine. Unimod:327 DiffAvg: 44.11 DiffFormula: C 2 H 4 O -1 S 1 DiffMono: 44.008457 Formula: C 5 H 9 N 1 O 1 S 1 MassAvg: 131.19 MassMono: 131.040485 Origin: S Source: artifact TermSpec: none Unimod: Unimod:327 Delta:H(4)C(2)O(-1)S(1) S-Ethylcystine from Serine A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with a (13)C,3x(2)H labeled methyl group to form a 1x(13)C,3x(2)H labeled monomethylated L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Methyl:2H(3)13C(1) monomethylated arginine MOD:00637 1x(13)C,3x(2)H labeled monomethylated L-arginine MOD:00637 A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with a (13)C,3x(2)H labeled methyl group to form a 1x(13)C,3x(2)H labeled monomethylated L-arginine. Unimod:329 DiffAvg: 18.04 DiffFormula: (13)C 1 (1)H -1 (2)H 3 DiffMono: 18.037835 Formula: (12)C 6 (13)C 1 (1)H 11 (2)H 3 N 4 O 1 MassAvg: 174.14 MassMono: 174.138946 Origin: R Source: artifact TermSpec: none Unimod: Unimod:329 Methyl:2H(3)13C(1) monomethylated arginine A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Dimethyl:2H(6)13C(2) dimethylated arginine MOD:00638 2x(13)C,6x(2)H labeled dimethylated L-arginine MOD:00638 A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-arginine. PubMed:15782174 Unimod:330 DiffAvg: 36.08 DiffFormula: (13)C 2 (1)H -2 (2)H 6 DiffMono: 36.075670 Formula: (12)C 6 (13)C 2 (1)H 10 (2)H 6 N 4 O 1 MassAvg: 192.18 MassMono: 192.176781 Origin: R Source: artifact TermSpec: none Unimod: Unimod:330 Dimethyl:2H(6)13C(2) dimethylated arginine modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Thiophos-S-S-biotin thiophosphate labeled with biotin-HPDP MOD:00639 thiophosphate labeled with biotin-HPDP MOD:00639 modification from Unimod Chemical derivative Unimod:332 DiffAvg: 525.66 DiffFormula: C 19 H 34 N 4 O 5 P 1 S 3 DiffMono: 525.142895 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:332 Thiophos-S-S-biotin thiophosphate labeled with biotin-HPDP modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 6-N-biotinylaminohexyl isopropyl phosphate Can-FP-biotin MOD:00640 6-N-biotinylaminohexyl isopropyl phosphorofluoridate MOD:00640 modification from Unimod Chemical derivative Unimod:333 DiffAvg: 467.54 DiffFormula: C 19 F 1 H 35 N 3 O 5 P 1 S 1 DiffMono: 467.201907 Formula: C 22 F 1 H 40 N 4 O 7 P 1 S 1 MassAvg: 554.62 MassMono: 554.233935 Origin: S Source: artifact TermSpec: none Unimod: Unimod:333 6-N-biotinylaminohexyl isopropyl phosphate Can-FP-biotin OBSOLETE because Unimod entry 334 is merged with Unimod 293. Remap to MOD:00612 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00641 CAMthiopropanoyl of Lys true MOD:00641 OBSOLETE because Unimod entry 334 is merged with Unimod 293. Remap to MOD:00612 Unimod:334 DiffAvg: 146.18 DiffFormula: C 5 H 8 N 1 O 2 S 1 DiffMono: 146.027574 Formula: none MassAvg: none MassMono: none Origin: K Remap: MOD:00612 Source: artifact TermSpec: none Unimod: Unimod:334 A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HNE+Delta:H(2) reduced 4-Hydroxynonenal MOD:00642 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. reduced 4-hydroxynonenal adduct MOD:00642 A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. PubMed:11910026 PubMed:15133838 Unimod:335 DiffAvg: 158.24 DiffFormula: C 9 H 18 O 2 DiffMono: 158.130680 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:335 HNE+Delta:H(2) reduced 4-Hydroxynonenal modification from Unimod Artifact DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Methylamine Michael addition with methylamine MOD:00643 methylamine Michael addition derivatized residue MOD:00643 modification from Unimod Artifact PubMed:11968134 Unimod:337 DiffAvg: 13.04 DiffFormula: C 1 H 3 N 1 O -1 DiffMono: 13.031634 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:337 Methylamine Michael addition with methylamine A protein modification that effectively replaces a residue hydroxyl group with an acetoxy group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: OAcRes PSI-MOD MOD:00644 mono O-acetylated residue MOD:00644 A protein modification that effectively replaces a residue hydroxyl group with an acetoxy group. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 O 1 DiffMono: 42.010565 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none OAcRes A protein modification that effectively replaces a residue sulfanyl group with an acetylsulfanyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: SAcRes PSI-MOD MOD:00645 mono S-acetylated residue MOD:00645 A protein modification that effectively replaces a residue sulfanyl group with an acetylsulfanyl group. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 O 1 S 0 DiffMono: 42.010565 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none SAcRes A protein modification that effectively converts an L-cysteine residue to either N-acetyl-L-cysteine or S-acetyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: AcCys PSI-MOD MOD:00646 monoacetylated L-cysteine MOD:00646 A protein modification that effectively converts an L-cysteine residue to either N-acetyl-L-cysteine or S-acetyl-L-cysteine. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 S 0 DiffMono: 42.010565 Formula: C 5 H 7 N 1 O 2 S 1 MassAvg: 145.18 MassMono: 145.019749 Origin: C Source: natural AcCys A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: AcSer PSI-MOD MOD:00647 monoacetylated L-serine MOD:00647 A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: none MassAvg: none MassMono: none Origin: S Source: natural AcSer A protein modification that effectively converts an L-serine residue to N,O-diacetyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-acetamido-3-acetyloxypropanoic acid N,O-diacetyl-L-serine N,O-diacetylserine NOAc2Ser PSI-MOD MOD:00648 In one paper, the samples were prepared using glacial acetic acid, and were probably artifactual [JSG]. N,O-diacetylated L-serine MOD:00648 A protein modification that effectively converts an L-serine residue to N,O-diacetyl-L-serine. PubMed:16731519 PubMed:489587 PubMed:7309355 RESID:AA0051#var RESID:AA0364#var DiffAvg: 84.07 DiffFormula: C 4 H 4 N 0 O 2 DiffMono: 84.021129 Formula: C 7 H 10 N 1 O 4 MassAvg: 172.16 MassMono: 172.060983 Origin: S Source: artifact TermSpec: N-term (S)-2-acetamido-3-acetyloxypropanoic acid N,O-diacetyl-L-serine N,O-diacetylserine NOAc2Ser A protein modification that effectively replaces a hydrogen atom with an acyl group. AcylRes PSI-MOD MOD:00649 acylated residue MOD:00649 A protein modification that effectively replaces a hydrogen atom with an acyl group. PubMed:18688235 AcylRes A protein modification that effectively replaces a residue amino group with a myristoylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: NMyrRes PSI-MOD MOD:00650 N-myristoylated residue MOD:00650 A protein modification that effectively replaces a residue amino group with a myristoylamino group. PubMed:18688235 DiffAvg: 210.36 DiffFormula: C 14 H 26 O 1 DiffMono: 210.198365 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none NMyrRes A protein modification that effectively replaces a residue amino group with a palmitoylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N-hexadecanoylated residue NPamRes PSI-MOD MOD:00651 N-palmitoylated residue MOD:00651 A protein modification that effectively replaces a residue amino group with a palmitoylamino group. PubMed:18688235 DiffAvg: 238.41 DiffFormula: C 16 H 30 O 1 DiffMono: 238.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none N-hexadecanoylated residue NPamRes A protein modification that effectively replaces a residue hydroxyl group with a palmitoyloxy group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: O-hexadecanoylated residue OPamRes PSI-MOD MOD:00652 O-palmitoylated residue MOD:00652 A protein modification that effectively replaces a residue hydroxyl group with a palmitoyloxy group. PubMed:18688235 DiffAvg: 238.41 DiffFormula: C 16 H 30 O 1 DiffMono: 238.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none O-hexadecanoylated residue OPamRes A protein modification that effectively replaces a residue sulfanyl group with an palmitoylsulfanyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: S-hexadecanoylated residue SPamRes PSI-MOD MOD:00653 S-palmitoylated residue MOD:00653 A protein modification that effectively replaces a residue sulfanyl group with an palmitoylsulfanyl group. PubMed:18688235 DiffAvg: 238.41 DiffFormula: C 16 H 30 O 1 S 0 DiffMono: 238.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none S-hexadecanoylated residue SPamRes a protein modification that effectively replaces a sulfanyl group with a methylsulfanyl group SMeRes PSI-MOD MOD:00654 S-methylated residue MOD:00654 a protein modification that effectively replaces a sulfanyl group with a methylsulfanyl group PubMed:18688235 SMeRes A protein modification that effectively replaces a residue sulfanyl group with an myristoylsulfanyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: SMyrRes PSI-MOD MOD:00655 S-myristoylated residue MOD:00655 A protein modification that effectively replaces a residue sulfanyl group with an myristoylsulfanyl group. PubMed:18688235 DiffAvg: 210.36 DiffFormula: C 14 H 26 O 1 S 0 DiffMono: 210.198365 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none SMyrRes A protein modification that effectively replaces a residue hydrocarbyl hydrogen with an methyl group. CMeRes PSI-MOD MOD:00656 C-methylated residue MOD:00656 A protein modification that effectively replaces a residue hydrocarbyl hydrogen with an methyl group. PubMed:18688235 CMeRes A protein modification that effectively converts an L-glutamine residue to L-glutamate 5-methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0127 (2S)-2-amino-5-methoxy-5-oxopentanoic acid (5)-methyl L-hydrogen glutamate 2-aminopentanedioic acid 5-methyl ester 5-methyl L-2-aminoglutarate 5-methyl L-glutamate L-glutamic acid 5-methyl ester MOD_RES Glutamate methyl ester (Gln) O5MeGlu(Gln) deamidated 5-methyl esterified glutamine glutamic acid 5-methyl ester glutamic acid gamma-methyl ester PSI-MOD Deamidation followed by a methylation Methyl+Deamidated MOD:00657 This is known to be a natural modification of glutamine in prokaryotes. L-glutamic acid 5-methyl ester (Gln) MOD:00657 A protein modification that effectively converts an L-glutamine residue to L-glutamate 5-methyl ester. PubMed:16888 PubMed:6300110 RESID:AA0072#GLN Unimod:528 DiffAvg: 15.01 DiffFormula: C 1 H 1 N -1 O 1 DiffMono: 14.999666 Formula: C 6 H 9 N 1 O 3 MassAvg: 143.14 MassMono: 143.058243 Origin: Q Source: natural TermSpec: none Unimod: Unimod:528 (2S)-2-amino-5-methoxy-5-oxopentanoic acid (5)-methyl L-hydrogen glutamate 2-aminopentanedioic acid 5-methyl ester 5-methyl L-2-aminoglutarate 5-methyl L-glutamate L-glutamic acid 5-methyl ester MOD_RES Glutamate methyl ester (Gln) O5MeGlu(Gln) deamidated 5-methyl esterified glutamine glutamic acid 5-methyl ester glutamic acid gamma-methyl ester Deamidation followed by a methylation Methyl+Deamidated A protein modification that effectively converts an L-arginine residue to a methylated arginine, either 5-methylargine, N5-methylarginine, or an omega-N-methylated L-arginine. Origin: uniprot.ptm:PTM-0238 MeArg PSI-MOD MOD:00658 methylated arginine MOD:00658 A protein modification that effectively converts an L-arginine residue to a methylated arginine, either 5-methylargine, N5-methylarginine, or an omega-N-methylated L-arginine. PubMed:18688235 Origin: R MeArg A protein modification that effectively converts an L-glutamine residue to a methylated glutamine, either 2-methylated glutamine, N5-methylated glutamine, or methyl esterified deamidated glutamine. Origin: Source: TermSpec: MeGln PSI-MOD MOD:00659 methylated glutamine MOD:00659 A protein modification that effectively converts an L-glutamine residue to a methylated glutamine, either 2-methylated glutamine, N5-methylated glutamine, or methyl esterified deamidated glutamine. PubMed:18688235 Origin: Q Source: natural TermSpec: none MeGln A protein modification that effectively converts an L-cysteine residue to a methylated cysteine, either S-methylcysteine, or cysteine methyl ester. Origin: Source: TermSpec: MeCys PSI-MOD MOD:00660 methylated cysteine MOD:00660 A protein modification that effectively converts an L-cysteine residue to a methylated cysteine, either S-methylcysteine, or cysteine methyl ester. PubMed:18688235 Origin: C Source: natural TermSpec: none MeCys A protein modification that effectively converts an L-histidine residue to a methylated histidine, such as pros-methylhistidine, or tele-methylhistidine. Origin: Source: TermSpec: MeHis PSI-MOD MOD:00661 methylated histidine MOD:00661 A protein modification that effectively converts an L-histidine residue to a methylated histidine, such as pros-methylhistidine, or tele-methylhistidine. PubMed:18688235 Origin: H Source: natural TermSpec: none MeHis A protein modification that effectively converts an L-leucine residue to a methylated leucine, either N-methylleucine, or leucine methyl ester. Origin: Source: TermSpec: MeLeu PSI-MOD MOD:00662 methylated leucine MOD:00662 A protein modification that effectively converts an L-leucine residue to a methylated leucine, either N-methylleucine, or leucine methyl ester. PubMed:18688235 Origin: L Source: natural TermSpec: none MeLeu A protein modification that effectively converts an L-lysine residue to a methylated lysine. Origin: Source: TermSpec: uniprot.ptm:PTM-0193 MeLys PSI-MOD MOD:00663 methylated lysine MOD:00663 A protein modification that effectively converts an L-lysine residue to a methylated lysine. PubMed:18688235 Origin: K Source: natural TermSpec: none MeLys A protein modification that effectively replaces a residue L-enantiomer (stereoisomer) with a D-enantiomer or with a different diastereomeric isomer. D-Res PSI-MOD MOD:00664 stereoisomerized residue MOD:00664 A protein modification that effectively replaces a residue L-enantiomer (stereoisomer) with a D-enantiomer or with a different diastereomeric isomer. PubMed:18688235 D-Res A protein modification that effectively converts an L-alanine residue to a methylated alanine, such as N-methylalanine, N,N-dimethylalanine, or N,N,N-trimethylalanine. Origin: Source: TermSpec: MeAla PSI-MOD MOD:00665 methylated alanine MOD:00665 A protein modification that effectively converts an L-alanine residue to a methylated alanine, such as N-methylalanine, N,N-dimethylalanine, or N,N,N-trimethylalanine. PubMed:18688235 Origin: A Source: natural TermSpec: none MeAla A protein modification that effectively replaces a hydrogen atom with an octanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: OctRes PSI-MOD MOD:00666 octanoylated residue MOD:00666 A protein modification that effectively replaces a hydrogen atom with an octanoyl group. PubMed:18688235 DiffAvg: 126.20 DiffFormula: C 8 H 14 N 0 O 1 DiffMono: 126.104465 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none OctRes A protein modification that effectively replaces a hydrogen atom with a decanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: DecRes PSI-MOD MOD:00667 decanoylated residue MOD:00667 A protein modification that effectively replaces a hydrogen atom with a decanoyl group. PubMed:18688235 DiffAvg: 154.25 DiffFormula: C 10 H 18 N 0 O 1 DiffMono: 154.135765 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none DecRes A protein modification that effectively replaces a residue hydroxyl group with a decanoyloxy group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: ODecRes PSI-MOD Decanoyl lipid MOD:00668 O-decanoylated residue MOD:00668 A protein modification that effectively replaces a residue hydroxyl group with a decanoyloxy group. Unimod:449 DiffAvg: 154.25 DiffFormula: C 10 H 18 N 0 O 1 DiffMono: 154.135765 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:449 ODecRes Decanoyl lipid A protein modification that effectively replaces a residue hydroxyl group with a octanoyloxy group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: OOctRes PSI-MOD Octanoyl octanoyl MOD:00669 O-octanoylated residue MOD:00669 A protein modification that effectively replaces a residue hydroxyl group with a octanoyloxy group. Unimod:426 DiffAvg: 126.20 DiffFormula: C 8 H 14 N 0 O 1 DiffMono: 126.104465 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:426 OOctRes Octanoyl octanoyl A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group. NAcylRes PSI-MOD MOD:00670 N-acylated residue MOD:00670 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group. PubMed:18688235 NAcylRes A protein modification that effectively replaces a residue hydroxyl group with a acyloxy group. OAcylRes PSI-MOD MOD:00671 O-acylated residue MOD:00671 A protein modification that effectively replaces a residue hydroxyl group with a acyloxy group. PubMed:18688235 OAcylRes A protein modification that effectively replaces a residue sulfanyl group with an acylsulfanyl group. SAcylRes PSI-MOD MOD:00672 S-acylated residue MOD:00672 A protein modification that effectively replaces a residue sulfanyl group with an acylsulfanyl group. PubMed:18688235 SAcylRes A protein modification that effectively converts an L-asparagine residue to a methylated asparagine, such as N4-methyl-L-asparagine, or N4,N4-dimethyl-L-asparagine. Origin: Source: TermSpec: MeAsn PSI-MOD MOD:00673 methylated asparagine MOD:00673 A protein modification that effectively converts an L-asparagine residue to a methylated asparagine, such as N4-methyl-L-asparagine, or N4,N4-dimethyl-L-asparagine. PubMed:18688235 Origin: N Source: natural TermSpec: none MeAsn A protein modification that effectively replaces a carboxyl group with a carboxamido group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00674 amidated residue MOD:00674 A protein modification that effectively replaces a carboxyl group with a carboxamido group. PubMed:18688235 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none A protein modification that effectively either removes neutral hydrogen atoms (proton and electron), or adds oxygen atoms to a residue with or without the removal of hydrogen atoms. Origin: Source: TermSpec: OxRes PSI-MOD MOD:00675 oxidized residue MOD:00675 A protein modification that effectively either removes neutral hydrogen atoms (proton and electron), or adds oxygen atoms to a residue with or without the removal of hydrogen atoms. PubMed:18688235 Origin: X Source: none TermSpec: none OxRes A protein modification that effectively adds oxygen atoms to a residue with or without the removal of hydrogen atoms. Origin: Source: TermSpec: OxyRes PSI-MOD MOD:00676 oxygenated residue MOD:00676 A protein modification that effectively adds oxygen atoms to a residue with or without the removal of hydrogen atoms. PubMed:18688235 Origin: X Source: none TermSpec: none OxyRes A protein modification that effectively replaces a hydrogen atom with an hydroxyl group. Origin: Source: TermSpec: HyRes Hydroxylation (of delta C of Lysine, beta C of Tryptophan, C3 or C4 of Proline, beta C of Aspartate) PSI-MOD MOD:00677 From DeltaMass: Average Mass: 16 hydroxylated residue MOD:00677 A protein modification that effectively replaces a hydrogen atom with an hydroxyl group. DeltaMass:0 Origin: X Source: none TermSpec: none HyRes Hydroxylation (of delta C of Lysine, beta C of Tryptophan, C3 or C4 of Proline, beta C of Aspartate) A protein modification that effectively converts an L-proline residue to an hydroxylated L-proline. Origin: Source: TermSpec: HyPro PSI-MOD MOD:00678 hydroxylated proline MOD:00678 A protein modification that effectively converts an L-proline residue to an hydroxylated L-proline. PubMed:18688235 Origin: P Source: none TermSpec: none HyPro A protein modification that effectively adds oxygen atoms to a carbon atom of a residue and removes hydrogen atoms. COxyRes PSI-MOD MOD:00679 carbon oxygenated residue MOD:00679 A protein modification that effectively adds oxygen atoms to a carbon atom of a residue and removes hydrogen atoms. PubMed:18688235 COxyRes A protein modification that effectively adds oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms. SOxyRes PSI-MOD MOD:00680 sulfur oxygenated residue MOD:00680 A protein modification that effectively adds oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms. PubMed:18688235 SOxyRes A protein modification that effectively converts an L-lysine residue to a hydroxylated L-lysine. Origin: HyLys PSI-MOD MOD:00681 hydroxylated lysine MOD:00681 A protein modification that effectively converts an L-lysine residue to a hydroxylated L-lysine. PubMed:18688235 Origin: K HyLys A protein modification that effectively converts an L-arginine residue to a hydroxylated L-arginine. Origin: uniprot.ptm:PTM-0498 HyArg PSI-MOD MOD:00682 hydroxylated arginine MOD:00682 A protein modification that effectively converts an L-arginine residue to a hydroxylated L-arginine. PubMed:18688235 Origin: R HyArg A protein modification that effectively removes neutral hydrogen atoms (proton and electron) from a residue. Origin: dHRes PSI-MOD MOD:00683 dehydrogenated residue MOD:00683 A protein modification that effectively removes neutral hydrogen atoms (proton and electron) from a residue. PubMed:18688235 Origin: X dHRes A protein modification that effectively converts an L-asparagine residue to L-aspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0116 (2S)-2-aminobutanedioic acid 2-azanylbutanedioic acid L-aspartic acid MOD_RES Deamidated asparagine aminosuccinic acid dNAsn PSI-MOD MOD:00684 incidental to RESID:AA0059 deamidated L-asparagine MOD:00684 A protein modification that effectively converts an L-asparagine residue to L-aspartic acid. PubMed:1097438 PubMed:339692 PubMed:4399050 PubMed:5764436 PubMed:6692818 PubMed:8089117 PubMed:9521123 PubMed:9582379 RESID:AA0004#ASN Unimod:7#N DiffAvg: 0.98 DiffFormula: C 0 H -1 N -1 O 1 DiffMono: 0.984016 Formula: C 4 H 5 N 1 O 3 MassAvg: 115.09 MassMono: 115.026943 Origin: N Source: natural TermSpec: none Unimod: Unimod:7 (2S)-2-aminobutanedioic acid 2-azanylbutanedioic acid L-aspartic acid MOD_RES Deamidated asparagine aminosuccinic acid dNAsn A protein modification that effectively converts an L-glutamine residue to L-glutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0117 (2S)-2-aminopentanedioic acid 1-aminopropane-1,3-dicarboxylic acid 2-aminoglutaric acid 2-azanylpentanedioic acid L-glutamic acid MOD_RES Deamidated glutamine alpha-aminoglutaric acid dNGln glutaminic acid PSI-MOD MOD:00685 deamidated L-glutamine MOD:00685 A protein modification that effectively converts an L-glutamine residue to L-glutamic acid. PubMed:1881881 PubMed:4565668 PubMed:4922541 PubMed:6692818 PubMed:9192900 PubMed:957425 RESID:AA0006#GLN Unimod:7#Q DiffAvg: 0.98 DiffFormula: C 0 H -1 N -1 O 1 DiffMono: 0.984016 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: Q Source: natural TermSpec: none Unimod: Unimod:7 (2S)-2-aminopentanedioic acid 1-aminopropane-1,3-dicarboxylic acid 2-aminoglutaric acid 2-azanylpentanedioic acid L-glutamic acid MOD_RES Deamidated glutamine alpha-aminoglutaric acid dNGln glutaminic acid A protein modification that effectively converts an L-cysteine residue to L-selenocysteine (not known as a natural, post-translational modification process). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2R)-2-amino-3-selanylpropanoic acid 2-azanyl-3-selanylpropanoic acid 3-selenylalanine L-selenocysteine NON_STD Selenocysteine SeCys Sec(Cys) selenium cysteine PSI-MOD MOD:00686 This entry is for the artifactual formation of L-selenocysteine from cysteine. For encoded L-selenocysteine, use MOD:00031 [JSG]. L-selenocysteine (Cys) MOD:00686 A protein modification that effectively converts an L-cysteine residue to L-selenocysteine (not known as a natural, post-translational modification process). PubMed:10523135 PubMed:2037562 PubMed:2963330 PubMed:6217842 PubMed:6714945 RESID:AA0022#CYS Unimod:162#C DiffAvg: 46.91 DiffFormula: C 0 H 0 N 0 O 0 S -1 Se 1 DiffMono: 47.944450 Formula: C 3 H 5 N 1 O 1 Se 1 MassAvg: 150.05 MassMono: 150.953635 Origin: C Source: artifact TermSpec: none Unimod: Unimod:162 (2R)-2-amino-3-selanylpropanoic acid 2-azanyl-3-selanylpropanoic acid 3-selenylalanine L-selenocysteine NON_STD Selenocysteine SeCys Sec(Cys) selenium cysteine A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and either an alkyl C as in lanthionine, or an aryl C as 2'-(S-cysteinyl)-L-histidine. PSI-MOD MOD:00687 thioether crosslinked residues MOD:00687 A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and either an alkyl C as in lanthionine, or an aryl C as 2'-(S-cysteinyl)-L-histidine. PubMed:18688235 A protein modification that crosslinks two residues with an amide bond where either the donor amino or carboxyl is not an alpha group. PSI-MOD MOD:00688 isopeptide crosslinked residues MOD:00688 A protein modification that crosslinks two residues with an amide bond where either the donor amino or carboxyl is not an alpha group. PubMed:18688235 A protein modification that crosslinks two cysteine residues by formation of a disulfide bond. PSI-MOD MOD:00689 disulfide crosslinked residues MOD:00689 A protein modification that crosslinks two cysteine residues by formation of a disulfide bond. PubMed:18688235 A protein modification that crosslinks two residues by formation of an oxazole or thiazole ring. PSI-MOD MOD:00690 oxazole/thiazole ring crosslinked residues MOD:00690 A protein modification that crosslinks two residues by formation of an oxazole or thiazole ring. PubMed:18688235 A protein modification that crosslinks two residues by formation of an 5-imidazolinone ring. PSI-MOD MOD:00691 5-imidazolinone ring crosslinked residues MOD:00691 A protein modification that crosslinks two residues by formation of an 5-imidazolinone ring. PubMed:18688235 A protein crosslink modification that is not chemically categorized. PSI-MOD MOD:00692 uncategorized crosslinked residues MOD:00692 A protein crosslink modification that is not chemically categorized. PubMed:18688235 A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond. Source: GlycoRes PSI-MOD MOD:00693 glycosylated residue MOD:00693 A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond. PubMed:18688235 Source: natural GlycoRes A protein modification that effectively substitutes a halogen atom for a hydrogen atom. HalRes halogenated residue PSI-MOD MOD:00694 halogen containing residue MOD:00694 A protein modification that effectively substitutes a halogen atom for a hydrogen atom. PubMed:18688235 HalRes halogenated residue A protein modification that effectively substitutes a sulfonyl group for the hydrogen atom of a hydroxyl or sulfanyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: SulfRes Sulphonation (SO3H) (of PMC group) PSI-MOD O-Sulfonation Sulfo MOD:00695 From DeltaMass: Average Mass: 80. sulfated residue MOD:00695 A protein modification that effectively substitutes a sulfonyl group for the hydrogen atom of a hydroxyl or sulfanyl group. DeltaMass:0 PubMed:14752058 Unimod:40 DiffAvg: 80.06 DiffFormula: O 3 S 1 DiffMono: 79.956815 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:40 SulfRes Sulphonation (SO3H) (of PMC group) O-Sulfonation Sulfo A protein modification that effectively replaces a hydrogen atom with a phosphono group (H2PO3 or 'phosphate'). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PhosRes Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) PSI-MOD Phospho Phosphorylation MOD:00696 From DeltaMass: Average Mass: 80. phosphorylated residue MOD:00696 A protein modification that effectively replaces a hydrogen atom with a phosphono group (H2PO3 or 'phosphate'). DeltaMass:0 Unimod:21 DiffAvg: 79.98 DiffFormula: H 1 O 3 P 1 DiffMono: 79.966331 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:21 PhosRes Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) Phospho Phosphorylation A protein modification that effectively results from forming an adduct with a compound containing a flavin group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: FlavRes PSI-MOD FAD Flavin adenine dinucleotide MOD:00697 flavin modified residue MOD:00697 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none FlavRes FAD Flavin adenine dinucleotide A protein modification that effectively substitutes a metal atom or a metal cluster for hydrogen atoms, or coordinates a metal ion. MetalRes PSI-MOD MOD:00698 metal or metal cluster containing modified residue MOD:00698 A protein modification that effectively substitutes a metal atom or a metal cluster for hydrogen atoms, or coordinates a metal ion. PubMed:18688235 MetalRes A protein modification that effectively results from forming an adduct with a compound containing a porphyrin group. PorphRes PSI-MOD MOD:00699 porphyrin modified residue MOD:00699 A protein modification that effectively results from forming an adduct with a compound containing a porphyrin group. PubMed:18688235 PorphRes A protein modification that effectively results from forming an adduct with a compound containing a tetrapyrrole group. TetrapyrRes PSI-MOD MOD:00700 tetrapyrrole modified residue MOD:00700 A protein modification that effectively results from forming an adduct with a compound containing a tetrapyrrole group. PubMed:18688235 TetrapyrRes A protein modification that effectively results from forming an adduct with a compound containing a nucleotide or a polynucleotide through formation of either a phosphodiester bond, a phosphoramide ester bond, or a glycosidic bond. NucRes PSI-MOD MOD:00701 nucleotide or nucleic acid modified residue MOD:00701 A protein modification that effectively results from forming an adduct with a compound containing a nucleotide or a polynucleotide through formation of either a phosphodiester bond, a phosphoramide ester bond, or a glycosidic bond. PubMed:18688235 NucRes A protein modification that effectively substitutes atoms of particular common isotopes with atoms or groups containing isotopes that are not the most common. IsoTagRes SILAC PSI-MOD MOD:00702 In SILAC (stable isotope labelling of amino acids in cell culture), the label may be introduced either through labeling of an incorporated residue or labeling of the substrates in a metabolic modification. For isotope labeling introduced through a modification reagent see MOD:01426. isotope labeled residue MOD:00702 A protein modification that effectively substitutes atoms of particular common isotopes with atoms or groups containing isotopes that are not the most common. PubMed:18688235 IsoTagRes SILAC A protein modification that effectively replaces a hydrogen atom with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20) group. IpRes PSI-MOD MOD:00703 isoprenylated residue MOD:00703 A protein modification that effectively replaces a hydrogen atom with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20) group. PubMed:18688235 IpRes A protein modification that effectively forms a double bond by removing a molecule of water from a residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Dehydrated Dehydration MOD:00704 dehydrated residue MOD:00704 A protein modification that effectively forms a double bond by removing a molecule of water from a residue. DeltaMass:0 Unimod:23 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:23 Dehydrated Dehydration A protein modification that effectively converts an L-valine residue to D-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0124 (R)-2-amino-3-methylbutanoic acid D-Val D-valine MOD_RES D-valine alpha-amino-beta-methylbutyric acid alpha-aminoisovaleric acid PSI-MOD MOD:00705 D-valine MOD:00705 A protein modification that effectively converts an L-valine residue to D-valine. ChEBI:30016 PubMed:15853325 RESID:AA0200 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 5 H 9 N 1 O 1 MassAvg: 99.13 MassMono: 99.068414 Origin: V Source: natural TermSpec: none (R)-2-amino-3-methylbutanoic acid D-Val D-valine MOD_RES D-valine alpha-amino-beta-methylbutyric acid alpha-aminoisovaleric acid A protein modification that effectively converts L-tyrosine to 2,3-didehydrotyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0008 MOD_RES 2,3-didehydrotyrosine dHTyr PSI-MOD MOD:00706 dehydrogenated tyrosine MOD:00706 A protein modification that effectively converts L-tyrosine to 2,3-didehydrotyrosine. Unimod:401#Y DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 9 H 7 N 1 O 2 MassAvg: 161.16 MassMono: 161.047678 Origin: Y Source: natural TermSpec: none Unimod: Unimod:401 MOD_RES 2,3-didehydrotyrosine dHTyr a protein modification that effectively converts an L-tyrosine residue to a multihydroxylated L-phenylalanine Origin: Source: TermSpec: HyTyr PSI-MOD MOD:00707 hydroxylated tyrosine MOD:00707 a protein modification that effectively converts an L-tyrosine residue to a multihydroxylated L-phenylalanine PubMed:18688235 Origin: Y Source: natural TermSpec: none HyTyr A protein modification that effectively adds oxygen atoms to a sulfur atom of L-cysteine residue without removing hydrogen atoms. Origin: Source: TermSpec: SOxyCys PSI-MOD MOD:00708 sulfur oxygenated L-cysteine MOD:00708 A protein modification that effectively adds oxygen atoms to a sulfur atom of L-cysteine residue without removing hydrogen atoms. PubMed:18688235 Origin: C Source: artifact TermSpec: none SOxyCys A protein modification that effectively adds oxygen atoms to a sulfur atom of L-methionine residue without removing hydrogen atoms. Origin: Source: TermSpec: SOxyMet PSI-MOD MOD:00709 sulfur oxygenated L-methionine MOD:00709 A protein modification that effectively adds oxygen atoms to a sulfur atom of L-methionine residue without removing hydrogen atoms. PubMed:18688235 Origin: M Source: artifact TermSpec: none SOxyMet A protein modification that effectively adds a proton and replaces two hydrogen atoms with two methyl groups. Me2+Res PSI-MOD MOD:00710 For N-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts for both protonation and dimethylation. The alternative Me2Res process accounts only for dimethylation and not protonation. protonated-dimethylated residue MOD:00710 A protein modification that effectively adds a proton and replaces two hydrogen atoms with two methyl groups. PubMed:18688235 Me2+Res A protein modification that effectively replaces three hydrogen atoms with three methyl groups, after a proton has been added to form an aminium group. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Me3+Res PSI-MOD MOD:00711 For amino acids residues, amine trimethylation can effectively only be accomplished with a protonated primary amino group. This process accounts for both protonation and trimethylation. The alternative Me3Res process accounts only for trimethylation and not protonation. trimethylated protonated-residue MOD:00711 A protein modification that effectively replaces three hydrogen atoms with three methyl groups, after a proton has been added to form an aminium group. PubMed:18688235 DiffAvg: 43.09 DiffFormula: C 3 H 7 N 0 O 0 S 0 DiffMono: 43.054227 FormalCharge: 1+ Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Me3+Res A protein modification that effectively converts an L-proline residue to a methylated proline, such as N,N-dimethylproline. Origin: Source: TermSpec: MePro PSI-MOD MOD:00712 methylated proline MOD:00712 A protein modification that effectively converts an L-proline residue to a methylated proline, such as N,N-dimethylproline. PubMed:18688235 Origin: P Source: natural TermSpec: none MePro A protein modification that effectively converts an L-glutamic acid residue to a methylated glutamic acid, such as L-glutamate 5-methyl ester. Origin: Source: TermSpec: MeGlu PSI-MOD MOD:00713 methylated glutamic acid MOD:00713 A protein modification that effectively converts an L-glutamic acid residue to a methylated glutamic acid, such as L-glutamate 5-methyl ester. PubMed:18688235 Origin: X Source: natural TermSpec: none MeGlu A protein modification that effectively converts a glycine residue to a methylated glycine, such as N-methylglycine. Origin: Source: TermSpec: MeGly PSI-MOD MOD:00714 methylated glycine MOD:00714 A protein modification that effectively converts a glycine residue to a methylated glycine, such as N-methylglycine. PubMed:18688235 Origin: G Source: natural TermSpec: none MeGly A protein modification that effectively converts an L-isoleucine residue to a methylated isoleucine residue, such as N-methyl-L-isoleucine. Origin: Source: TermSpec: MeIle PSI-MOD MOD:00715 methylated isoleucine MOD:00715 A protein modification that effectively converts an L-isoleucine residue to a methylated isoleucine residue, such as N-methyl-L-isoleucine. PubMed:18688235 Origin: I Source: natural TermSpec: none MeIle A protein modification that effectively converts an L-methionine residue to a methylated methionine, such as N-methyl-L-methionine. Origin: Source: TermSpec: MeMet PSI-MOD MOD:00716 methylated methionine MOD:00716 A protein modification that effectively converts an L-methionine residue to a methylated methionine, such as N-methyl-L-methionine. PubMed:18688235 Origin: M Source: natural TermSpec: N-term MeMet A protein modification that effectively converts an L-phenylalanine residue to a methylated phenylalanine, such as N-methyl-L-phenylalanine. Origin: Source: TermSpec: MePhe PSI-MOD MOD:00717 methylated phenylalanine MOD:00717 A protein modification that effectively converts an L-phenylalanine residue to a methylated phenylalanine, such as N-methyl-L-phenylalanine. PubMed:18688235 Origin: F Source: natural TermSpec: none MePhe A protein modification that effectively converts an L-tyrosine residue to a methylated tyrosine, such as N-methyl-L-tyrosine. Origin: Source: TermSpec: MeTyr PSI-MOD MOD:00718 methylated tyrosine MOD:00718 A protein modification that effectively converts an L-tyrosine residue to a methylated tyrosine, such as N-methyl-L-tyrosine. PubMed:18688235 Origin: Y Source: natural TermSpec: N-term MeTyr A protein modification that oxygenates an L-methionine residue to one of the diastereomeric L-methionine sulfoxide residues. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0469 (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid L-methionine (R)-S-oxide L-methionine (R)-sulfoxide L-methionine S-oxide L-methionine sulfoxide MOD_RES Methionine sulfoxide MetO Methionyl Sulfoxide oxym PSI-MOD Oxidation MOD:00719 From DeltaMass: Average Mass: 147 Formula:C5H9O1N2S Monoisotopic Mass Change:147.035 Average Mass Change:147.195 (formula incorrect, N and O reversed) References:PE Sciex. L-methionine sulfoxide MOD:00719 A protein modification that oxygenates an L-methionine residue to one of the diastereomeric L-methionine sulfoxide residues. DeltaMass:177 OMSSA:1 PubMed:21406390 PubMed:22116028 RESID:AA0581 Unimod:35#M DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 S 0 DiffMono: 15.994915 Formula: C 5 H 9 N 1 O 2 S 1 MassAvg: 147.19 MassMono: 147.035400 Origin: M Source: artifact TermSpec: none Unimod: Unimod:35 (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid L-methionine (R)-S-oxide L-methionine (R)-sulfoxide L-methionine S-oxide L-methionine sulfoxide MOD_RES Methionine sulfoxide MetO Methionyl Sulfoxide oxym Oxidation A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide R-diastereomer. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0480 (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid L-methionine (R)-S-oxide L-methionine (R)-sulfoxide MOD_RES Methionine (R)-sulfoxide R-MetO PSI-MOD MOD:00720 L-methionine (R)-sulfoxide MOD:00720 A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide R-diastereomer. ChEBI:45764 PubMed:21406390 PubMed:22116028 PubMed:23911929 RESID:AA0581 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 S 0 DiffMono: 15.994915 Formula: C 5 H 9 N 1 O 2 S 1 MassAvg: 147.19 MassMono: 147.035400 Origin: M Source: natural TermSpec: none (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid L-methionine (R)-S-oxide L-methionine (R)-sulfoxide MOD_RES Methionine (R)-sulfoxide R-MetO A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide S-diastereomer. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0481 MOD_RES Methionine (S)-sulfoxide S-MetO PSI-MOD MOD:00721 L-methionine (S)-sulfoxide MOD:00721 A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide S-diastereomer. PubMed:18688235 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 S 0 DiffMono: 15.994915 Formula: C 5 H 9 N 1 O 2 S 1 MassAvg: 147.19 MassMono: 147.035400 Origin: M Source: artifact TermSpec: none MOD_RES Methionine (S)-sulfoxide S-MetO A protein modification that effectively replaces one hydrogen atom of an L-glutamine residue with one methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Me1Gln methylq PSI-MOD MOD:00722 monomethylated L-glutamine MOD:00722 A protein modification that effectively replaces one hydrogen atom of an L-glutamine residue with one methyl group. OMSSA:14 Unimod:34#Q DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 6 H 10 N 2 O 2 MassAvg: 142.16 MassMono: 142.074228 Origin: Q Source: natural TermSpec: none Unimod: Unimod:34 Me1Gln methylq A protein modification that effectively converts an L-lysine residue to either N2-acetyl-L-lysine, or N6-acetyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: NAcLys PSI-MOD MOD:00723 N-acetylated L-lysine MOD:00723 A protein modification that effectively converts an L-lysine residue to either N2-acetyl-L-lysine, or N6-acetyl-L-lysine. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 8 H 15 N 2 O 2 MassAvg: 171.22 MassMono: 171.113353 Origin: K Source: natural TermSpec: none NAcLys A protein modification that effectively replaces one hydrogen atom on a nitrogen of an L-histidine residue with one methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: NMeHis methylh PSI-MOD Methyl MOD:00724 N-methylated L-histidine MOD:00724 A protein modification that effectively replaces one hydrogen atom on a nitrogen of an L-histidine residue with one methyl group. OMSSA:74 Unimod:34#H DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 9 N 3 O 1 MassAvg: 151.17 MassMono: 151.074562 Origin: H Source: natural TermSpec: none Unimod: Unimod:34 NMeHis methylh Methyl A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group linked through a glycosidic bond. PSI-MOD MOD:00725 complex glycosylation MOD:00725 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group linked through a glycosidic bond. PubMed:18688235 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a glucose group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Glc PSI-MOD MOD:00726 glucosylated residue MOD:00726 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a glucose group through a glycosidic bond. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00433 Source: natural TermSpec: none Glc A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a mannose group through a glycosidic bond, DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Man PSI-MOD MOD:00727 mannosylated residue MOD:00727 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a mannose group through a glycosidic bond, PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Man A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a galactose group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Gal PSI-MOD MOD:00728 galactosylated residue MOD:00728 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a galactose group through a glycosidic bond. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Gal a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a pentose sugar group through a glycosidic bond DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Pent Pentoses (Ara, Rib, Xyl) Pentosyl PSI-MOD MOD:00729 for Pentoses DeltaMass gives mass 132, for Pentosyl DeltaMass gives formula C 6 H 10 N4 with mass 146 pentosylated residue MOD:00729 a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a pentose sugar group through a glycosidic bond DeltaMass:172 DiffAvg: 132.12 DiffFormula: C 5 H 8 O 4 DiffMono: 132.042259 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Pent Pentoses (Ara, Rib, Xyl) Pentosyl a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a arabinose sugar group through a glycosidic bond DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Ara PSI-MOD MOD:00730 arabinosylated residue MOD:00730 a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a arabinose sugar group through a glycosidic bond PubMed:18688235 DiffAvg: 132.12 DiffFormula: C 5 H 8 O 4 DiffMono: 132.042259 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Ara a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a ribose sugar group through a glycosidic bond DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Rib PSI-MOD MOD:00731 ribosylated residue MOD:00731 a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a ribose sugar group through a glycosidic bond PubMed:18688235 DiffAvg: 132.12 DiffFormula: C 5 H 8 O 4 DiffMono: 132.042259 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Rib a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a xylose sugar group through a glycosidic bond DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Xyl PSI-MOD MOD:00732 xylosylated residue MOD:00732 a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a xylose sugar group through a glycosidic bond PubMed:18688235 DiffAvg: 132.12 DiffFormula: C 5 H 8 O 4 DiffMono: 132.042259 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Xyl A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylglucosamine group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: GlcNAc PSI-MOD MOD:00733 N-acetylaminoglucosylated residue MOD:00733 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylglucosamine group through a glycosidic bond. PubMed:18688235 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none GlcNAc A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylgalactosamine group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: GalNAc N-acetylhexosamines (GalNAc, GlcNAc) PSI-MOD MOD:00734 From DeltaMass: Average Mass: 203 Formula:C8H13O5N1 Monoisotopic Mass Change:203.079 Average Mass Change:203.196 References:PE Sciex N-acetylaminogalactosylated residue MOD:00734 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylgalactosamine group through a glycosidic bond. DeltaMass:247 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none GalNAc N-acetylhexosamines (GalNAc, GlcNAc) A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosuronic acid group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: HexA PSI-MOD MOD:00735 hexosuronylated residue MOD:00735 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosuronic acid group through a glycosidic bond. PubMed:18688235 DiffAvg: 176.12 DiffFormula: C 6 H 8 O 6 DiffMono: 176.032088 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none HexA a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a deoxyhexose group through a glycosidic bond DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Deoxyhexoses (Fuc, Rha) dHex PSI-MOD MOD:00736 From DeltaMass: Average Mass: 146 deoxyhexosylated residue MOD:00736 a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a deoxyhexose group through a glycosidic bond DeltaMass:0 DiffAvg: 146.14 DiffFormula: C 6 H 10 O 4 DiffMono: 146.057909 Formula: none GNOme: GNO:G02438LG MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Deoxyhexoses (Fuc, Rha) dHex A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylneuraminic acid (sialic acid) group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: N-acetylneuraminic acid (Sialic acid, NeuAc, NANA, SA) NeuNAc PSI-MOD MOD:00737 From DeltaMass: Average Mass: 291 N-acetylneuraminylated residue MOD:00737 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylneuraminic acid (sialic acid) group through a glycosidic bond. DeltaMass:0 DiffAvg: 291.26 DiffFormula: C 11 H 17 N 1 O 8 DiffMono: 291.095417 Formula: none GNOme: GNO:G76685HR MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none N-acetylneuraminic acid (Sialic acid, NeuAc, NANA, SA) NeuNAc A protein modification that effectively substitutes an iron atom or a cluster containing iron for hydrogen atoms, or that coordinates an iron ion. FeRes PSI-MOD MOD:00738 iron containing modified residue MOD:00738 A protein modification that effectively substitutes an iron atom or a cluster containing iron for hydrogen atoms, or that coordinates an iron ion. PubMed:18688235 FeRes A protein modification that effectively substitutes a cluster of iron and sulfur atoms for hydrogen atoms. FeSRes PSI-MOD MOD:00739 iron-sulfur cluster containing modification MOD:00739 A protein modification that effectively substitutes a cluster of iron and sulfur atoms for hydrogen atoms. PubMed:18688235 FeSRes A protein modification that effectively substitutes a manganese atom or a cluster containing manganese for hydrogen atoms, or that coordinates a manganese ion. MnRes PSI-MOD MOD:00740 manganese containing modified residue MOD:00740 A protein modification that effectively substitutes a manganese atom or a cluster containing manganese for hydrogen atoms, or that coordinates a manganese ion. PubMed:18688235 MnRes A protein modification that effectively substitutes a nickel atom or a cluster containing nickel for hydrogen atoms, or that coordinates a nickel ion. NiRes PSI-MOD MOD:00741 nickel containing modified residue MOD:00741 A protein modification that effectively substitutes a nickel atom or a cluster containing nickel for hydrogen atoms, or that coordinates a nickel ion. PubMed:18688235 NiRes A protein modification that effectively substitutes a copper atom or a cluster containing copper for hydrogen atoms, or that coordinates a copper ion. CuRes PSI-MOD MOD:00742 copper containing modified residue MOD:00742 A protein modification that effectively substitutes a copper atom or a cluster containing copper for hydrogen atoms, or that coordinates a copper ion. PubMed:18688235 CuRes A protein modification that effectively substitutes a molybdenum atom or a cluster containing molybdenum for hydrogen atoms, or that coordinates a molybdenum ion. MoRes PSI-MOD MOD:00743 molybdenum containing modified residue MOD:00743 A protein modification that effectively substitutes a molybdenum atom or a cluster containing molybdenum for hydrogen atoms, or that coordinates a molybdenum ion. PubMed:18688235 MoRes A protein modification containing a molybdenum atom in a pterin ring system. MoPterRes PSI-MOD MOD:00744 molybdenum pterin containing modification MOD:00744 A protein modification containing a molybdenum atom in a pterin ring system. PubMed:18688235 MoPterRes A protein modification that effectively substitutes a selenium atom or a cluster containing selenium for hydrogen atoms. SeRes PSI-MOD MOD:00745 selenium containing residue MOD:00745 A protein modification that effectively substitutes a selenium atom or a cluster containing selenium for hydrogen atoms. PubMed:18688235 SeRes A protein modification that effectively substitutes a tungsten atom or a cluster containing tungsten for hydrogen atoms, or that coordinates a tungsten ion. WRes PSI-MOD MOD:00746 tungsten containing modified residue MOD:00746 A protein modification that effectively substitutes a tungsten atom or a cluster containing tungsten for hydrogen atoms, or that coordinates a tungsten ion. PubMed:18688235 WRes A protein modification that effectively substitutes a sodium atom for a hydrogen atom. NaRes PSI-MOD MOD:00747 sodium containing modified residue MOD:00747 A protein modification that effectively substitutes a sodium atom for a hydrogen atom. PubMed:18688235 NaRes A protein modification that effectively results from forming an adduct with a compound containing a pterin group. PterRes PSI-MOD MOD:00748 pterin modified residue MOD:00748 A protein modification that effectively results from forming an adduct with a compound containing a pterin group. PubMed:18688235 PterRes A protein modification that effectively substitutes a sulfur atom for an oxygen atom. S(O)Res PSI-MOD MOD:00749 sulfur substitution for oxygen MOD:00749 A protein modification that effectively substitutes a sulfur atom for an oxygen atom. PubMed:18688235 S(O)Res A protein modification that effectively crosslinks an amino acid residue and the 3'- or 5'-end of DNA through a phosphodiester bond. DNARes PSI-MOD MOD:00750 deoxyribonucleic acid linked residue MOD:00750 A protein modification that effectively crosslinks an amino acid residue and the 3'- or 5'-end of DNA through a phosphodiester bond. PubMed:18688235 DNARes a protein modification RNARes PSI-MOD MOD:00751 ribonucleic acid linked residue MOD:00751 a protein modification PubMed:18688235 RNARes A protein modification that effectively results from forming an adduct with one ADP-ribose through formation of a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: ADP-rybosylation (from NAD) ADPRib1Res PSI-MOD MOD:00752 From DeltaMass: Average Mass: 541. monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue MOD:00752 A protein modification that effectively results from forming an adduct with one ADP-ribose through formation of a glycosidic bond. DeltaMass:0 DiffAvg: 541.30 DiffFormula: C 15 H 21 N 5 O 13 P 2 DiffMono: 541.061109 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none ADP-rybosylation (from NAD) ADPRib1Res A protein modification that effectively substitutes a chlorine atom for a hydrogen atom. Origin: Source: TermSpec: ClRes PSI-MOD MOD:00753 chlorinated residue MOD:00753 A protein modification that effectively substitutes a chlorine atom for a hydrogen atom. PubMed:18688235 Origin: X Source: none TermSpec: none ClRes A protein modification that effectively substitutes a bromine atom for a hydrogen atom. Origin: Source: TermSpec: BrRes PSI-MOD MOD:00754 brominated residue MOD:00754 A protein modification that effectively substitutes a bromine atom for a hydrogen atom. PubMed:18688235 Origin: X Source: none TermSpec: none BrRes A protein modification that effectively substitutes an iodine atom of a residue for a hydrogen atom. Origin: Source: TermSpec: IRes PSI-MOD MOD:00755 iodinated residue MOD:00755 A protein modification that effectively substitutes an iodine atom of a residue for a hydrogen atom. PubMed:18688235 Origin: X Source: none TermSpec: none IRes A protein modification that effectively converts an L-valine residue to 4-hydroxy-D-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0111 (2R,3Xi)-2-amino-4-hydroxy-3-methylbutanoic acid 4-hydroxy-D-valine D-4HyVal D-gamma-hydroxyvaline MOD_RES D-4-hydroxyvaline PSI-MOD MOD:00756 4-hydroxy-D-valine MOD:00756 A protein modification that effectively converts an L-valine residue to 4-hydroxy-D-valine. PubMed:15853325 RESID:AA0388 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 5 H 9 N 1 O 2 MassAvg: 115.13 MassMono: 115.063329 Origin: V Source: natural TermSpec: none (2R,3Xi)-2-amino-4-hydroxy-3-methylbutanoic acid 4-hydroxy-D-valine D-4HyVal D-gamma-hydroxyvaline MOD_RES D-4-hydroxyvaline A protein modification that effectively converts an L-proline residue to O4-galactosyl-L-hydroxyproline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0558 (2S,4R)-4-(beta-D-galactopyranosyloxy)pyrrolidine-2-carboxylic acid 4-(beta-D-galactopyranosyloxy)proline 4-(galactosyloxy)proline CARBOHYD O-linked (Gal) hydroxyproline O4-galactosyl-L-hydroxyproline O4-glycosyl-hydroxyproline beta-galactopyranosyl-4-hydroxyproline PSI-MOD MOD:00757 secondary to RESID:AA0030 O4-galactosyl-L-hydroxyproline MOD:00757 A protein modification that effectively converts an L-proline residue to O4-galactosyl-L-hydroxyproline. RESID:AA0389 DiffAvg: 178.14 DiffFormula: C 6 H 10 N 0 O 6 DiffMono: 178.047738 Formula: C 11 H 17 N 1 O 7 MassAvg: 275.26 MassMono: 275.100502 Origin: P Source: natural TermSpec: none (2S,4R)-4-(beta-D-galactopyranosyloxy)pyrrolidine-2-carboxylic acid 4-(beta-D-galactopyranosyloxy)proline 4-(galactosyloxy)proline CARBOHYD O-linked (Gal) hydroxyproline O4-galactosyl-L-hydroxyproline O4-glycosyl-hydroxyproline beta-galactopyranosyl-4-hydroxyproline A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)glucosyl-L-hydroxyproline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0578 (2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-glucopyranosyloxy]pyrrolidine-2-carboxylic acid 4-(N-acetylglucosaminyloxy)proline 4-[(2-N-acetylamino)-alpha-D-glucopyranosyl]oxyproline CARBOHYD O-linked (GlcNAc) hydroxyproline O4-(N-acetylamino)glucosyl-L-hydroxyproline O4-glycosyl-hydroxyproline O4GlcNAcHyPro alpha-2-(N-acetylamino)glucopyranosyl-4-hydroxyproline PSI-MOD HexNAc MOD:00758 secondary to RESID:AA0030 O4-(N-acetylamino)glucosyl-L-hydroxyproline MOD:00758 A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)glucosyl-L-hydroxyproline. PubMed:15238247 PubMed:9660787 RESID:AA0390 DiffAvg: 219.19 DiffFormula: C 8 H 13 N 1 O 6 DiffMono: 219.074287 Formula: C 13 H 20 N 2 O 7 MassAvg: 316.31 MassMono: 316.127051 Origin: P Source: natural TermSpec: none (2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-glucopyranosyloxy]pyrrolidine-2-carboxylic acid 4-(N-acetylglucosaminyloxy)proline 4-[(2-N-acetylamino)-alpha-D-glucopyranosyl]oxyproline CARBOHYD O-linked (GlcNAc) hydroxyproline O4-(N-acetylamino)glucosyl-L-hydroxyproline O4-glycosyl-hydroxyproline O4GlcNAcHyPro alpha-2-(N-acetylamino)glucopyranosyl-4-hydroxyproline HexNAc modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Fucosylated biantennary (-1 galactose) dHex(1)Hex(4)HexNAc(4) MOD:00759 fucosylated biantennary (-1 galactose) N4-glycosylated asparagine MOD:00759 modification from Unimod N-linked glycosylation Unimod:307 DiffAvg: 1607.48 DiffFormula: C 62 H 102 N 4 O 44 DiffMono: 1606.586693 Formula: C 66 H 108 N 6 O 46 GNOme: GNO:G59937CP MassAvg: 1721.59 MassMono: 1720.629620 Origin: N Source: natural TermSpec: none Unimod: Unimod:307 Fucosylated biantennary (-1 galactose) dHex(1)Hex(4)HexNAc(4) modification from Unimod N-linked glycosylation - missing ref DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Biantennary Hex(5)HexNAc(4) MOD:00760 biantennary N4-glycosylated asparagine MOD:00760 modification from Unimod N-linked glycosylation - missing ref Unimod:311 DiffAvg: 1623.48 DiffFormula: C 62 H 102 N 4 O 45 DiffMono: 1622.581607 Formula: C 66 H 108 N 6 O 47 GNOme: GNO:G10486CT MassAvg: 1737.59 MassMono: 1736.624535 Origin: N Source: natural TermSpec: none Unimod: Unimod:311 Biantennary Hex(5)HexNAc(4) A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with one hexose sugar group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Hex1 PSI-MOD MOD:00761 monohexosylated residue MOD:00761 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with one hexose sugar group through a glycosidic bond. PubMed:18688235 DiffAvg: 162.14 DiffFormula: C 6 H 10 O 5 DiffMono: 162.052823 Formula: none GNOme: GNO:G81399MY MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Hex1 modification from Unimod N-linked glycosylation - missing ref DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Biantennary (-2 galactose) Hex(3)HexNAc(4) MOD:00762 biantennary (-2 galactose) N4-glycosylated asparagine MOD:00762 modification from Unimod N-linked glycosylation - missing ref Unimod:309 DiffAvg: 1299.20 DiffFormula: C 50 H 82 N 4 O 35 DiffMono: 1298.475960 Formula: C 54 H 88 N 6 O 37 GNOme: GNO:G35029YA MassAvg: 1413.30 MassMono: 1412.518888 Origin: N Source: natural TermSpec: none Unimod: Unimod:309 Biantennary (-2 galactose) Hex(3)HexNAc(4) modification from Unimod N-linked glycosylation - missing ref DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Biantennary (-1 galactose) Hex(4)HexNAc(4) MOD:00763 biantennary (-1 galactose) N4-glycosylated asparagine MOD:00763 modification from Unimod N-linked glycosylation - missing ref Unimod:310 DiffAvg: 1461.34 DiffFormula: C 56 H 92 N 4 O 40 DiffMono: 1460.528784 Formula: C 60 H 98 N 6 O 42 GNOme: GNO:G72787SB MassAvg: 1575.44 MassMono: 1574.571711 Origin: N Source: natural TermSpec: none Unimod: Unimod:310 Biantennary (-1 galactose) Hex(4)HexNAc(4) A protein modification that effectively results from forming an adduct with a carbohydrate-like group either through enzymatic formation of a glycosidic bond, or through non-enzymatic glycation formation of a Schiff-base or an Amadori ketosamine residue adduct. PSI-MOD MOD:00764 glycoconjugated residue MOD:00764 A protein modification that effectively results from forming an adduct with a carbohydrate-like group either through enzymatic formation of a glycosidic bond, or through non-enzymatic glycation formation of a Schiff-base or an Amadori ketosamine residue adduct. PubMed:18688235 PubMed:3743566 A protein modification that effectively converts an L-cysteine residue to S-(L-cysteinyl)-L-cysteine, forming a disulfide bond with free cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0415 (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) 3,3'-dithiobis(2-aminopropanoic acid) 3,3'-dithiobisalanine 3,3'-dithiodialanine Cysteinylation L-cystine MOD_RES S-cysteinyl cysteine S-cystenyl cystenyl SCysCys beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide beta,beta'-dithiodialanine bis(alpha-aminopropionic acid)-beta-disulfide bis(beta-amino-beta-carboxyethyl)disulfide dicysteine PSI-MOD 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid MOD:00765 This entry is for formation of a disulfide bond between a peptide cysteine and a free cysteine. For the cystine cross-link, see MOD:00234. From DeltaMass: (name misspelled and formula incorrect, N and O reversed) Formula: C6H10O2N3S2 Monoisotopic Mass Change: 222.013 Average Mass Change: 222.283 cysteinylation (disulfide with free L-cysteine) MOD:00765 A protein modification that effectively converts an L-cysteine residue to S-(L-cysteinyl)-L-cysteine, forming a disulfide bond with free cysteine. DeltaMass:260 PubMed:1988019 PubMed:2001356 PubMed:2076469 PubMed:3083866 PubMed:366603 PubMed:7918467 PubMed:8344916 RESID:AA0025#CYS1 Unimod:312 DiffAvg: 119.14 DiffFormula: C 3 H 5 N 1 O 2 S 1 DiffMono: 119.004099 Formula: C 6 H 10 N 2 O 3 S 2 MassAvg: 222.28 MassMono: 222.013284 Origin: C Source: natural TermSpec: none Unimod: Unimod:312 (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) 3,3'-dithiobis(2-aminopropanoic acid) 3,3'-dithiobisalanine 3,3'-dithiodialanine Cysteinylation L-cystine MOD_RES S-cysteinyl cysteine S-cystenyl cystenyl SCysCys beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide beta,beta'-dithiodialanine bis(alpha-aminopropionic acid)-beta-disulfide bis(beta-amino-beta-carboxyethyl)disulfide dicysteine 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid modification from Unimod Post-translational - C-terminal loss of lysine OBSOLETE because the idenical to MOD:01642. Remap to MOD:01642 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: TermSpec: Unimod: PSI-MOD Loss of C-terminal K from Heavy Chain of MAb Lys-loss MOD:00766 C terminal -K from HC of MAb true MOD:00766 modification from Unimod Post-translational - C-terminal loss of lysine OBSOLETE because the idenical to MOD:01642. Remap to MOD:01642 PubMed:16078144 Unimod:313 DiffAvg: -128.18 DiffFormula: C -6 H -12 N -2 O -1 DiffMono: -128.094963 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:01642 TermSpec: C-term Unimod: Unimod:313 Loss of C-terminal K from Heavy Chain of MAb Lys-loss A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein amino group to form a Schiff-base or an Amadori ketosamine residue adduct. Source: PSI-MOD MOD:00767 glycated residue MOD:00767 A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein amino group to form a Schiff-base or an Amadori ketosamine residue adduct. PubMed:18688235 Source: artifact Oxidation of methionine to methionine sulfone with neutral loss of CH3SO2H. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00768 Originally created from Unimod:508 that was later deleted. methionine oxidation with neutral loss of 80 Da MOD:00768 Oxidation of methionine to methionine sulfone with neutral loss of CH3SO2H. PubMed:18688235 PubMed:9004526 DiffAvg: -80.10 DiffFormula: C -1 H -4 N 0 O -2 S -1 DiffMono: -79.993200 Formula: C 4 H 5 N 1 O 1 S 0 MassAvg: 83.09 MassMono: 83.037114 Origin: M Source: artifact TermSpec: none Natural or modified residues with a mass of 71.0-71.1 Da. PSI-MOD MOD:00769 residues isobaric at 71.0-71.1 Da MOD:00769 Natural or modified residues with a mass of 71.0-71.1 Da. PubMed:18688235 Natural or modified residues that are isobaric at a resolution below 0.01 Da. PSI-MOD MOD:00770 residues isobaric at a resolution below 0.01 Da MOD:00770 Natural or modified residues that are isobaric at a resolution below 0.01 Da. PubMed:18688235 Natural or modified residues with a mass of 166.98-167.00 Da. PSI-MOD MOD:00771 residues isobaric at 166.98-167.00 Da MOD:00771 Natural or modified residues with a mass of 166.98-167.00 Da. PubMed:18688235 A protein modification that effectively substitutes a vanadium atom or a cluster containing vanadium for hydrogen atoms, or that coordinates a vanadium ion. VRes PSI-MOD MOD:00772 vanadium containing modified residue MOD:00772 A protein modification that effectively substitutes a vanadium atom or a cluster containing vanadium for hydrogen atoms, or that coordinates a vanadium ion. PubMed:18688235 VRes Natural or modified residues with a mass of 181.00-181.02 Da. PSI-MOD MOD:00773 residues isobaric at 181.00-181.02 Da MOD:00773 Natural or modified residues with a mass of 181.00-181.02 Da. PubMed:18688235 Natural or modified residues with a mass of 243.02-243.03 Da. PSI-MOD MOD:00774 residues isobaric at 243.02-243.03 Da MOD:00774 Natural or modified residues with a mass of 243.02-243.03 Da. PubMed:18688235 An artifactual protein modification that converts an L-histidine residue to L-asparagine by oxidative degradation. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: his2asnh PSI-MOD His->Asn histidine oxidation to aspargine MOD:00775 L-asparagine (His) MOD:00775 An artifactual protein modification that converts an L-histidine residue to L-asparagine by oxidative degradation. OMSSA:54 PubMed:9252331 Unimod:348 DiffAvg: -23.04 DiffFormula: C -2 H -1 N -1 O 1 DiffMono: -23.015984 Formula: C 4 H 6 N 2 O 2 MassAvg: 114.10 MassMono: 114.042927 Origin: H Source: artifact TermSpec: none Unimod: Unimod:348 his2asnh His->Asn histidine oxidation to aspargine An artifactual protein modification that converts an L-histidine residue to L-aspartic acid by oxidative degradation. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: his2asph PSI-MOD His->Asp histidine oxidation to aspartic acid MOD:00776 From OMSSA: desc="oxidation of H to D" monomass= -23.015984 (this is the same mass difference as OMSSA:54, his2asnh) [JSG]. L-aspartic acid (His) MOD:00776 An artifactual protein modification that converts an L-histidine residue to L-aspartic acid by oxidative degradation. OMSSA:55 PubMed:9252331 Unimod:349 DiffAvg: -22.05 DiffFormula: C -2 H -2 N -2 O 2 DiffMono: -22.031969 Formula: C 4 H 5 N 1 O 3 MassAvg: 115.09 MassMono: 115.026943 Origin: H Source: artifact TermSpec: none Unimod: Unimod:349 his2asph His->Asp histidine oxidation to aspartic acid Natural or modified residues with a mass of 182.96-182.98 Da. PSI-MOD MOD:00777 residues isobaric at 182.96-182.98 Da MOD:00777 Natural or modified residues with a mass of 182.96-182.98 Da. PubMed:18688235 Natural or modified residues with a mass of 182.9-183.0 Da. PSI-MOD MOD:00778 residues isobaric at 182.9-183.0 Da MOD:00778 Natural or modified residues with a mass of 182.9-183.0 Da. PubMed:18688235 OBSOLETE because redundant with MOD:00130. Remap to MOD:00130. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: Oxidation of lysine (to aminoadipic semialdehyde) PSI-MOD MOD:00779 From DeltaMass: Average Mass: -1 Average Mass Change:-1 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. lysine oxidation to aminoadipic semialdehyde true MOD:00779 OBSOLETE because redundant with MOD:00130. Remap to MOD:00130. DeltaMass:352 PubMed:11332453 PubMed:358196 PubMed:5337886 PubMed:5529814 Unimod:352 DiffAvg: -1.03 DiffFormula: H -3 N -1 O 1 DiffMono: -1.031634 Formula: none MassAvg: none MassMono: none Origin: K Remap: MOD:00130 Source: natural TermSpec: none Unimod: Unimod:352 Oxidation of lysine (to aminoadipic semialdehyde) A protein modification that effectively converts an L-asparagine residue to N-acetyl-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: AcAsn PSI-MOD MOD:00780 This modification has not been observed to occur naturally. N-acetyl-L-asparagine MOD:00780 A protein modification that effectively converts an L-asparagine residue to N-acetyl-L-asparagine. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 6 H 8 N 2 O 3 MassAvg: 156.14 MassMono: 156.053492 Origin: N Source: artifact TermSpec: N-term AcAsn A protein modification that effectively converts an L-histidine residue to N2-acetyl-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: AcHis PSI-MOD MOD:00781 This modification has not been observed to occur naturally. N2-acetyl-L-histidine MOD:00781 A protein modification that effectively converts an L-histidine residue to N2-acetyl-L-histidine. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 8 H 9 N 3 O 2 MassAvg: 179.18 MassMono: 179.069477 Origin: H Source: artifact TermSpec: N-term AcHis A protein modification that effectively converts an L-leucine residue to N-acetyl-L-leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: AcLeu PSI-MOD MOD:00782 This modification has not been observed to occur naturally. N-acetyl-L-leucine MOD:00782 A protein modification that effectively converts an L-leucine residue to N-acetyl-L-leucine. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 8 H 14 N 1 O 2 MassAvg: 156.20 MassMono: 156.102454 Origin: L Source: artifact TermSpec: N-term AcLeu A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two methyl groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0341 NNMe2Arg dimethylr PSI-MOD Dimethyl MOD:00783 dimethylated L-arginine MOD:00783 A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two methyl groups. OMSSA:37 Unimod:36#R DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 8 H 16 N 4 O 1 MassAvg: 184.24 MassMono: 184.132411 Origin: R Source: natural TermSpec: none Unimod: Unimod:36 NNMe2Arg dimethylr Dimethyl A protein modification that effectively converts an L-phenylalanine residue to N-acetyl-L-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: AcPhe PSI-MOD MOD:00784 This modification has not been observed to occur naturally. N-acetyl-L-phenylalanine MOD:00784 A protein modification that effectively converts an L-phenylalanine residue to N-acetyl-L-phenylalanine. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 11 H 11 N 1 O 2 MassAvg: 189.21 MassMono: 189.078979 Origin: F Source: artifact TermSpec: N-term AcPhe A protein modification that effectively converts an L-tryptophan residue to N2-acetyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: AcTrp PSI-MOD MOD:00785 This modification has not been observed to occur naturally. N2-acetyl-L-tryptophan MOD:00785 A protein modification that effectively converts an L-tryptophan residue to N2-acetyl-L-tryptophan. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 13 H 12 N 2 O 2 MassAvg: 228.25 MassMono: 228.089878 Origin: W Source: artifact TermSpec: N-term AcTrp A protein modification that effectively substitutes one or more (2)H deuterium atoms for (1)H protium atoms. D(H)Res PSI-MOD MOD:00786 deuterium substituted residue MOD:00786 A protein modification that effectively substitutes one or more (2)H deuterium atoms for (1)H protium atoms. PubMed:18688235 D(H)Res modification from Unimod - label for the active site serine of the serine esterase/protease family also shown to label tyrosine in serum albumin DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Diisopropylphosphate O-Diisopropylphosphorylation MOD:00787 diisopropylphosphoserine MOD:00787 modification from Unimod - label for the active site serine of the serine esterase/protease family also shown to label tyrosine in serum albumin Unimod:362 DiffAvg: 164.14 DiffFormula: C 6 H 13 O 3 P 1 DiffMono: 164.060231 Formula: C 9 H 18 N 1 O 5 P 1 MassAvg: 251.22 MassMono: 251.092259 Origin: S Source: artifact TermSpec: none Unimod: Unimod:362 Diisopropylphosphate O-Diisopropylphosphorylation modification from Unimod DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Isopropylphospho O-Isopropylphosphorylation MOD:00788 isopropylphosphotyrosine MOD:00788 modification from Unimod Unimod:363 DiffAvg: 122.06 DiffFormula: C 3 H 7 O 3 P 1 DiffMono: 122.013281 Formula: C 12 H 16 N 1 O 5 P 1 MassAvg: 285.24 MassMono: 285.076609 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:363 Isopropylphospho O-Isopropylphosphorylation modification from Unimod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form ICPL:13C(6) MOD:00789 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form MOD:00789 modification from Unimod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied. PubMed:15602776 URL:http://www.serva.de/products/sheets/39230-E.pdf Unimod:364 DiffAvg: 111.04 DiffFormula: (13)C 6 H 3 N 1 O 1 DiffMono: 111.041593 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:364 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form ICPL:13C(6) modification from Unimod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form ICPL MOD:00790 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form MOD:00790 modification from Unimod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied. PubMed:15602776 URL:http://www.serva.de/products/sheets/39230-E.pdf Unimod:365 DiffAvg: 105.02 DiffFormula: (12)C 6 H 3 N 1 O 1 DiffMono: 105.021464 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:365 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form ICPL A protein modification that effectively converts an L-glutamine residue to L-glutamic acid with one (18)O. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Deamidated:18O(1) Deamidation in presence of O18 MOD:00791 1x(18)O labeled deamidated L-glutamine MOD:00791 A protein modification that effectively converts an L-glutamine residue to L-glutamic acid with one (18)O. PubMed:8382902 Unimod:366#Q DiffAvg: 2.99 DiffFormula: H -1 N -1 (18)O 1 DiffMono: 2.988262 Formula: C 5 H 7 N 1 (16)O 2 (18)O 1 MassAvg: 131.05 MassMono: 131.046839 Origin: Q Source: artifact TermSpec: none Unimod: Unimod:366 Deamidated:18O(1) Deamidation in presence of O18 A protein modification that effectively substitutes one (2)H deuterium atom for one (1)H protium atom. D(H)1Res PSI-MOD MOD:00792 deuterium monosubstituted residue MOD:00792 A protein modification that effectively substitutes one (2)H deuterium atom for one (1)H protium atom. PubMed:18688235 D(H)1Res A protein modification that effectively converts an L-cysteine residue to dehydroalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0468 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dehydroalanine (from Cysteine) Dha MOD_RES 2,3-didehydroalanine (Cys) anhydroserine dHAla(Cys) dehydroalanine PSI-MOD Cys->Dha Dehydroalanine (from Cysteine) MOD:00793 From DeltaMass: In an attempt to clarfiy the difference between the modification of cysteine to lanthionine and cysteine to dehydroalanine, the following contributions from the ABRF email forum are presented:Structurally speaking lanthionine is like cystine but lacks one S atom. I imagine one can think of it as a condensation of cysteine and dehydroalanine but I do not know how it is made biologically. Dehydroalanine could be derived from either serine or cysteine. If I recall Biochem 101 correctly lanthionine was first found in wool.-Lowell Ericsson (ERICSSONLH@U.WASHINGTON.EDU)As far as I know, the structure of lanthionine is two Ala's joined by a single sulphur with the loss of two hydrogens from the methyl group of the Ala.Stephen Bayne (sbay@novo.dk)Regarding the structure of lanthionine and dehydroalanine: dehydroalanine is formed by the loss of one sulfur atom and two hydrogen atoms from ONE cysteine residue. lanthionine is formed from TWO cysteines, is a thioether, and contains one sulfur atom less than the amino acid cystine. Dan McCormick (MCCORMICK@rcf.mayo.edu) [DeltaMass]. Most bacterially produced lanthionine crosslinks are made by dehydration of L-serine to dehydroalanine, and then reaction with L-cysteine so as to produce chiral inversion at the alpha-carbon of the original L-serine; the lanthionine is a meso-diastereomer with L-configuration of the original cysteine alpha-carbon and D-configuration of the original L-serine alpha-carbon. In cypemycin dehydroalanine has been shown to be produced by loss of hydrogen sulfide from cysteine. Beta-elimination of hydrogen sulfide does occur during treatment with performic acid [JSG]. dehydroalanine (Cys) MOD:00793 A protein modification that effectively converts an L-cysteine residue to dehydroalanine. ChEBI:17123 DeltaMass:8 PubMed:10220322 PubMed:11212008 PubMed:1547888 PubMed:15799070 PubMed:1815586 PubMed:20805503 PubMed:2914619 PubMed:7947813 PubMed:8239649 RESID:AA0181#CYS Unimod:368 DiffAvg: -34.08 DiffFormula: C 0 H -2 N 0 O 0 S -1 DiffMono: -33.987721 Formula: C 3 H 3 N 1 O 1 MassAvg: 69.06 MassMono: 69.021464 Origin: C Source: natural TermSpec: none Unimod: Unimod:368 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dehydroalanine (from Cysteine) Dha MOD_RES 2,3-didehydroalanine (Cys) anhydroserine dHAla(Cys) dehydroalanine Cys->Dha Dehydroalanine (from Cysteine) OBSOLETE because redundant and identical to MOD:00477. Remap to MOD:00477. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Pro->Pyrrolidone Pyrrolidone from Proline MOD:00794 This Unimod entry appears to have come from the same description in PubMed:9252331 as Unimod:360. This entry was not annotated as being approved. Neither difference formula corresponds to the result described in the original citation PubMed:2161657. pyrrolidone from proline true MOD:00794 OBSOLETE because redundant and identical to MOD:00477. Remap to MOD:00477. PubMed:9252331 Unimod:369 DiffAvg: -28.01 DiffFormula: C -1 O -1 DiffMono: -27.994915 Formula: C 4 H 7 N 1 O 0 MassAvg: 69.11 MassMono: 69.057849 Origin: P Remap: MOD:00477 Source: artifact TermSpec: none Unimod: Unimod:369 Pro->Pyrrolidone Pyrrolidone from Proline modification from Unimod DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HMVK Michael addition of hydroxymethylvinyl ketone to cysteine MOD:00795 Michael addition of hydroxymethylvinyl ketone to cysteine MOD:00795 modification from Unimod PubMed:11743741 Unimod:371 DiffAvg: 86.09 DiffFormula: C 4 H 6 O 2 DiffMono: 86.036779 Formula: C 7 H 11 N 1 O 3 S 1 MassAvg: 189.23 MassMono: 189.045964 Origin: C Source: artifact TermSpec: none Unimod: Unimod:371 HMVK Michael addition of hydroxymethylvinyl ketone to cysteine A protein modification that effectively converts an L-arginine residue to L-ornithine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Ornithine (from Arginine) Ornithyl arg2orn PSI-MOD Arg->Orn Ornithine from Arginine MOD:00796 L-ornithine (Arg) MOD:00796 A protein modification that effectively converts an L-arginine residue to L-ornithine. DeltaMass:129 OMSSA:163 PubMed:15489230 Unimod:372 DiffAvg: -42.04 DiffFormula: C -1 H -2 N -2 DiffMono: -42.021798 Formula: C 5 H 10 N 2 O 1 MassAvg: 114.15 MassMono: 114.079313 Origin: R Source: artifact TermSpec: none Unimod: Unimod:372 Ornithine (from Arginine) Ornithyl arg2orn Arg->Orn Ornithine from Arginine a protein modification that effectively converts an L-cysteine residue to the PEP adduct, 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0424 (2R)-2-amino-3-[1-carboxy-1-(phosphonooxy)ethyl]sulfanylpropanoic acid 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal 2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid 2-([(2R)-2-azanyl-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid MOD_RES 2-(S-cysteinyl)pyruvic acid O-phosphothioketal S-[1-carboxy-1-(phosphonooxy)ethyl]cysteine SPEPCys cysteinyl pyruvate O-phosphothioketal phosphoenolpyruvate cysteine adduct phospholactoyl cysteine adduct PSI-MOD MOD:00797 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal MOD:00797 a protein modification that effectively converts an L-cysteine residue to the PEP adduct, 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal ChEBI:149496 PubMed:4696757 PubMed:7999765 PubMed:8664284 RESID:AA0391 DiffAvg: 168.04 DiffFormula: C 3 H 5 N 0 O 6 P 1 S 0 DiffMono: 167.982375 Formula: C 6 H 10 N 1 O 7 P 1 S 1 MassAvg: 271.18 MassMono: 270.991559 Origin: C Source: natural TermSpec: none (2R)-2-amino-3-[1-carboxy-1-(phosphonooxy)ethyl]sulfanylpropanoic acid 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal 2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid 2-([(2R)-2-azanyl-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid MOD_RES 2-(S-cysteinyl)pyruvic acid O-phosphothioketal S-[1-carboxy-1-(phosphonooxy)ethyl]cysteine SPEPCys cysteinyl pyruvate O-phosphothioketal phosphoenolpyruvate cysteine adduct phospholactoyl cysteine adduct A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Dehydro Half of a disulfide bridge MOD:00798 half cystine MOD:00798 A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed. PubMed:1988019 PubMed:2001356 PubMed:2076469 PubMed:3083866 PubMed:366603 PubMed:7918467 PubMed:8344916 Unimod:374 DiffAvg: -1.01 DiffFormula: C 0 H -1 N 0 O 0 S 0 DiffMono: -1.007825 Formula: C 3 H 4 N 1 O 1 S 1 MassAvg: 102.13 MassMono: 102.001360 Origin: C Source: none TermSpec: none Unimod: Unimod:374 Dehydro Half of a disulfide bridge A protein modification that effectively converts an L-cysteine residue to S-galactosyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0624 (2R)-2-amino-3-(D-galactopyranosylsulfanyl)propanoic acid CARBOHYD S-linked (Gal) cysteine S-(beta-D-galactopyranosyl)cysteine S-galactosyl-L-cysteine S-glycosyl-cysteine SGalCys PSI-MOD MOD:00799 The reported peptide has not been isolated or characterized in subsequent work, and the peptide sequence has not been found in the human proteome. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. S-galactosyl-L-cysteine MOD:00799 A protein modification that effectively converts an L-cysteine residue to S-galactosyl-L-cysteine. PubMed:11945907 RESID:AA0392 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 S 0 DiffMono: 162.052823 Formula: C 9 H 15 N 1 O 6 S 1 MassAvg: 265.28 MassMono: 265.062008 Origin: C Source: artifact TermSpec: none (2R)-2-amino-3-(D-galactopyranosylsulfanyl)propanoic acid CARBOHYD S-linked (Gal) cysteine S-(beta-D-galactopyranosyl)cysteine S-galactosyl-L-cysteine S-glycosyl-cysteine SGalCys A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-vanadium seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: CysHis-[V7Fe9S] L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide carbide nitrogenase iron-vanadium cofactor PSI-MOD MOD:00800 Cross-link 2; incidental to RESID:AA0300. L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide MOD:00800 A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-vanadium seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide. PubMed:2345152 RESID:AA0393 DiffAvg: 932.51 DiffFormula: C 7 Fe 7 H 6 N 0 O 7 S 9 V 1 DiffMono: 932.248513 Formula: C 16 Fe 7 H 18 N 4 O 9 S 10 V 1 MassAvg: 1172.80 MassMono: 1172.316610 Origin: C, H Source: hypothetical TermSpec: none CysHis-[V7Fe9S] L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide carbide nitrogenase iron-vanadium cofactor A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and an eight-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl octairon nonasulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: CysHis-[8Fe9S] L-cysteinyl-L-histidino-homocitryl octairon nonasulfide carbide nitrogenase iron-iron cofactor PSI-MOD MOD:00801 Cross-link 2; incidental to RESID:AA0300. L-cysteinyl-L-histidino-homocitryl octairon nonasulfide MOD:00801 A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and an eight-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl octairon nonasulfide. PubMed:8392330 RESID:AA0394 DiffAvg: 937.42 DiffFormula: C 7 Fe 8 H 6 N 0 O 7 S 9 DiffMono: 937.240588 FormalCharge: 2- Formula: C 16 Fe 8 H 18 N 4 O 9 S 10 MassAvg: 1177.70 MassMono: 1177.308685 Origin: C, H Source: hypothetical TermSpec: none CysHis-[8Fe9S] L-cysteinyl-L-histidino-homocitryl octairon nonasulfide carbide nitrogenase iron-iron cofactor a protein modification that effectively converts an L-histidine residue to L-histidino vanadium tetraoxide DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (dihydroxy)dioxovanadium 1'-vanadato-L-histidine L-histidino vanadium tetraoxide N(tau)-vanadatohistidine NtauH2VO4His bromoperoxidase vanadium cofactor chloroperoxidase vanadium cofactor dihydrogen (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (tetraoxido)vanadate haloperoxidase vanadium cofactor histidine-1-vanadate histidine-N(epsilon)-vanadate histidine-N1'-vanadate tele-vanadatohistidine PSI-MOD MOD:00802 L-histidino vanadium tetraoxide MOD:00802 a protein modification that effectively converts an L-histidine residue to L-histidino vanadium tetraoxide PubMed:10543953 PubMed:16494433 PubMed:8552646 RESID:AA0395 DiffAvg: 116.95 DiffFormula: C 0 H 2 N 0 O 4 V 1 DiffMono: 116.939268 Formula: C 6 H 9 N 3 O 5 V 1 MassAvg: 254.10 MassMono: 253.998180 Origin: H Source: natural TermSpec: none (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (dihydroxy)dioxovanadium 1'-vanadato-L-histidine L-histidino vanadium tetraoxide N(tau)-vanadatohistidine NtauH2VO4His bromoperoxidase vanadium cofactor chloroperoxidase vanadium cofactor dihydrogen (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (tetraoxido)vanadate haloperoxidase vanadium cofactor histidine-1-vanadate histidine-N(epsilon)-vanadate histidine-N1'-vanadate tele-vanadatohistidine A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0020 (2S,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid 2-amino-3-(2-amino-2-carboxyethylthio)-3-(4-hydroxyphenyl)propanoic acid 3-(L-cystein-S-yl)-L-tyrosine CROSSLNK 3-(S-cysteinyl)-tyrosine (Cys-Tyr) S-(tyros-3'-yl)cysteine XLNKSCys3Tyr PSI-MOD MOD:00803 Cross-link 2. 3-(S-L-cysteinyl)-L-tyrosine MOD:00803 A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine. PubMed:15342250 RESID:AA0396 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 12 H 12 N 2 O 3 S 1 MassAvg: 264.30 MassMono: 264.056863 Origin: C, Y Source: natural TermSpec: none (2S,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid 2-amino-3-(2-amino-2-carboxyethylthio)-3-(4-hydroxyphenyl)propanoic acid 3-(L-cystein-S-yl)-L-tyrosine CROSSLNK 3-(S-cysteinyl)-tyrosine (Cys-Tyr) S-(tyros-3'-yl)cysteine XLNKSCys3Tyr A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0573 (2S)-2-amino-3-(beta-D-glucopyranosyloxy)propanoic acid CARBOHYD O-linked (Glc) serine CARBOHYD O-linked (Hex) O-glucosyl-L-serine O-glycosylserine O3-glucosylserine OGlcSer PSI-MOD MOD:00804 O-glucosyl-L-serine MOD:00804 A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine. PubMed:10734111 PubMed:2105311 PubMed:2511201 RESID:AA0397 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 9 H 15 N 1 O 7 MassAvg: 249.22 MassMono: 249.084852 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-(beta-D-glucopyranosyloxy)propanoic acid CARBOHYD O-linked (Glc) serine CARBOHYD O-linked (Hex) O-glucosyl-L-serine O-glycosylserine O3-glucosylserine OGlcSer A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminoglucosyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0580 (2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)propanoic acid CARBOHYD O-linked (GlcNAc) serine CARBOHYD O-linked (HexNAc) O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-serine O-(N-acetylamino)glucosyl-L-serine O-(N-acetylglucosaminyl)serine O-glycosylserine O-seryl-beta-N-acetylglucosaminide O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-serine O3-(N-acetylglucosaminyl)serine OGlcNAcSer PSI-MOD HexNAc MOD:00805 O-(N-acetylamino)glucosyl-L-serine MOD:00805 A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminoglucosyl)-L-serine. PubMed:3086323 PubMed:8404891 RESID:AA0398 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 11 H 18 N 2 O 7 MassAvg: 290.27 MassMono: 290.111401 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)propanoic acid CARBOHYD O-linked (GlcNAc) serine CARBOHYD O-linked (HexNAc) O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-serine O-(N-acetylamino)glucosyl-L-serine O-(N-acetylglucosaminyl)serine O-glycosylserine O-seryl-beta-N-acetylglucosaminide O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-serine O3-(N-acetylglucosaminyl)serine OGlcNAcSer HexNAc A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminoglucosyl)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0582 (2S,3R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)butanoic acid CARBOHYD O-linked (GlcNAc) threonine CARBOHYD O-linked (HexNAc) O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-threonine O-(N-acetylamino)glucosyl-L-threonine O-(N-acetylglucosaminyl)-L-threonine O-glycosylthreonine O-threonyl-beta-N-acetylglucosaminide O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-threonine O3-(N-acetylglucosaminyl)threonine OGlcNAcThr PSI-MOD HexNAc MOD:00806 O-(N-acetylamino)glucosyl-L-threonine MOD:00806 A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminoglucosyl)-L-threonine. PubMed:3086323 PubMed:8404891 RESID:AA0399 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 12 H 20 N 2 O 7 MassAvg: 304.30 MassMono: 304.127051 Origin: T Source: natural TermSpec: none (2S,3R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)butanoic acid CARBOHYD O-linked (GlcNAc) threonine CARBOHYD O-linked (HexNAc) O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-threonine O-(N-acetylamino)glucosyl-L-threonine O-(N-acetylglucosaminyl)-L-threonine O-glycosylthreonine O-threonyl-beta-N-acetylglucosaminide O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-threonine O3-(N-acetylglucosaminyl)threonine OGlcNAcThr HexNAc A protein modification that effectively converts an L-serine residue to pyruvic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0266 2-oxopropanoic acid MOD_RES Pyruvic acid (Ser) Pyruvate Pyruvoyl- (Serine) pyruvic acid PSI-MOD MOD:00807 DeltaMass gives mass 70 and difference mass -16 with no formula pyruvic acid (Ser) MOD:00807 A protein modification that effectively converts an L-serine residue to pyruvic acid. DeltaMass:23 PubMed:10085076 PubMed:3042771 PubMed:8464063 RESID:AA0127#SER Unimod:385#S DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 3 H 3 O 2 MassAvg: 71.06 MassMono: 71.013304 Origin: S Source: natural TermSpec: N-term Unimod: Unimod:385 2-oxopropanoic acid MOD_RES Pyruvic acid (Ser) Pyruvate Pyruvoyl- (Serine) pyruvic acid A protein modification that effectively converts an L-serine residue to O3-galactosylserine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0560 (2S)-2-amino-3-(alpha-D-galactopyranosyloxy)propanoic acid CARBOHYD O-linked (Gal) serine CARBOHYD O-linked (Hex) O-galactosyl-L-serine O-glycosylserine O3-galactosylserine OGalSer PSI-MOD MOD:00808 O-galactosyl-L-serine MOD:00808 A protein modification that effectively converts an L-serine residue to O3-galactosylserine. PubMed:666730 RESID:AA0400 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 9 H 15 N 1 O 7 MassAvg: 249.22 MassMono: 249.084852 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-(alpha-D-galactopyranosyloxy)propanoic acid CARBOHYD O-linked (Gal) serine CARBOHYD O-linked (Hex) O-galactosyl-L-serine O-glycosylserine O3-galactosylserine OGalSer A protein modification that effectively converts an L-threonine residue to O3-galactosylthreonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0562 (2S,3R)-2-amino-3-(alpha-D-galactopyranosyloxy)butanoic acid CARBOHYD O-linked (Gal) threonine CARBOHYD O-linked (Hex) O-galactosyl-L-threonine O-glycosylthreonine O3-galactosylthreonine OGalThr PSI-MOD MOD:00809 O-galactosyl-L-threonine MOD:00809 A protein modification that effectively converts an L-threonine residue to O3-galactosylthreonine. PubMed:2673008 RESID:AA0401 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 10 H 17 N 1 O 7 MassAvg: 263.25 MassMono: 263.100502 Origin: T Source: natural TermSpec: none (2S,3R)-2-amino-3-(alpha-D-galactopyranosyloxy)butanoic acid CARBOHYD O-linked (Gal) threonine CARBOHYD O-linked (Hex) O-galactosyl-L-threonine O-glycosylthreonine O3-galactosylthreonine OGalThr A protein modification that effectively converts an L-serine residue to O3-mannosylserine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0588 (2S)-2-amino-3-(alpha-D-mannopyranosyloxy)propanoic acid CARBOHYD O-linked (Hex) CARBOHYD O-linked (Man) serine O-glycosylserine O-mannopyranosylserine O-mannosyl-L-serine O3-mannosylserine OManSer PSI-MOD MOD:00810 O-mannosyl-L-serine MOD:00810 A protein modification that effectively converts an L-serine residue to O3-mannosylserine. PubMed:391559 RESID:AA0402 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 9 H 15 N 1 O 7 MassAvg: 249.22 MassMono: 249.084852 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-(alpha-D-mannopyranosyloxy)propanoic acid CARBOHYD O-linked (Hex) CARBOHYD O-linked (Man) serine O-glycosylserine O-mannopyranosylserine O-mannosyl-L-serine O3-mannosylserine OManSer a protein modification that effectively forms a O3-mannosylthreonine DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0591 (2S,3R)-2-amino-3-(alpha-D-mannopyranosyloxy)butanoic acid CARBOHYD O-linked (Hex) CARBOHYD O-linked (Man) threonine O-glycosylthreonine O-mannosyl-L-threonine O3-mannosylthreonine OManThr PSI-MOD MOD:00811 O-mannosyl-L-threonine MOD:00811 a protein modification that effectively forms a O3-mannosylthreonine PubMed:391559 RESID:AA0403 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 10 H 17 N 1 O 7 MassAvg: 263.25 MassMono: 263.100502 Origin: T Source: natural TermSpec: none (2S,3R)-2-amino-3-(alpha-D-mannopyranosyloxy)butanoic acid CARBOHYD O-linked (Hex) CARBOHYD O-linked (Man) threonine O-glycosylthreonine O-mannosyl-L-threonine O3-mannosylthreonine OManThr A protein modification that effectively converts an L-serine residue to an O-fucosylserine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0550 (2S)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)propanoic acid CARBOHYD O-linked (Fuc) CARBOHYD O-linked (Fuc) serine CARBOHYD O-linked (dHex) O-fucosyl-L-serine O-glycosylserine O3-fucosylserine OFucSer PSI-MOD Fucose dHex MOD:00812 O-fucosyl-L-serine MOD:00812 A protein modification that effectively converts an L-serine residue to an O-fucosylserine. PubMed:10734111 PubMed:11067851 PubMed:11344537 PubMed:12096136 PubMed:1517205 PubMed:15189151 PubMed:1904059 PubMed:3311742 PubMed:3578767 RESID:AA0404 Unimod:295#S DiffAvg: 146.14 DiffFormula: C 6 H 10 N 0 O 4 DiffMono: 146.057909 Formula: C 9 H 15 N 1 O 6 MassAvg: 233.22 MassMono: 233.089937 Origin: S Source: natural TermSpec: none Unimod: Unimod:295 (2S)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)propanoic acid CARBOHYD O-linked (Fuc) CARBOHYD O-linked (Fuc) serine CARBOHYD O-linked (dHex) O-fucosyl-L-serine O-glycosylserine O3-fucosylserine OFucSer Fucose dHex A protein modification that effectively converts an threonine residue to an O-fucosylthreonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0552 (2S,3R)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)butanoic acid CARBOHYD O-linked (Fuc) threonine CARBOHYD O-linked (dHex) O-fucosyl-L-threonine O-glycosylthreonine O3-fucosylthreonine OFucThr PSI-MOD Fucose dHex MOD:00813 O-fucosyl-L-threonine MOD:00813 A protein modification that effectively converts an threonine residue to an O-fucosylthreonine. PubMed:11344537 PubMed:11857757 PubMed:15189151 PubMed:1740125 PubMed:1900431 RESID:AA0405 Unimod:295#T DiffAvg: 146.14 DiffFormula: C 6 H 10 N 0 O 4 DiffMono: 146.057909 Formula: C 10 H 17 N 1 O 6 MassAvg: 247.25 MassMono: 247.105587 Origin: T Source: natural TermSpec: none Unimod: Unimod:295 (2S,3R)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)butanoic acid CARBOHYD O-linked (Fuc) threonine CARBOHYD O-linked (dHex) O-fucosyl-L-threonine O-glycosylthreonine O3-fucosylthreonine OFucThr Fucose dHex A protein modification that effectively converts an L-serine residue to O3-xylosylserine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0598 (2S)-2-amino-3-(alpha-D-xylopyranosyloxy)propanoic acid CARBOHYD O-linked (Xyl) serine O-(beta-D-xylopyranosyl)-L-serine O-glycosylserine O-xylosyl-L-serine O3-xylosylserine OXylSer PSI-MOD MOD:00814 One glycosylated serine with weak electron density was modeled as O3-alpha-xylosylserine, while O3-alpha-mannosyl serine and threonine were modeled at ten other positions. The authors do not discuss this exception or provide chemical evidence for it. Since an O3-xylosyl serine modification has not been reported in any other fungal proteins, the modification is probably also an O3-alpha-mannosyl serine, see MOD:00810 [JSG]. O-xylosyl-L-serine MOD:00814 A protein modification that effectively converts an L-serine residue to O3-xylosylserine. PubMed:8747463 RESID:AA0406 DiffAvg: 132.12 DiffFormula: C 5 H 8 N 0 O 4 DiffMono: 132.042259 Formula: C 8 H 13 N 1 O 6 MassAvg: 219.19 MassMono: 219.074287 Origin: S Source: artifact TermSpec: none (2S)-2-amino-3-(alpha-D-xylopyranosyloxy)propanoic acid CARBOHYD O-linked (Xyl) serine O-(beta-D-xylopyranosyl)-L-serine O-glycosylserine O-xylosyl-L-serine O3-xylosylserine OXylSer OBSOLETE because redundant with MOD:00151. Remap to MOD:00151. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00815 molybdopterin true MOD:00815 OBSOLETE because redundant with MOD:00151. Remap to MOD:00151. PubMed:14527393 PubMed:7878465 PubMed:9428520 DiffAvg: 520.27 DiffFormula: C 10 H 11 Mo 1 N 5 O 8 P 1 S 2 DiffMono: 521.884074 Formula: none MassAvg: none MassMono: none Origin: C Remap: MOD:00151 Source: natural TermSpec: none A protein modification that effectively converts an L-cysteine residue to S-stearoyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0283 (R)-2-amino-3-(octadecanoylsulfanyl)propanoic acid 2-amino-3-(octadecanoylthio)propanoic acid LIPID S-stearoyl cysteine S-stearoyl-L-cysteine SSteCys Stearoylation cysteine octadecanoate thioester cysteine stearate thioester PSI-MOD MOD:00816 From DeltaMass: Average Mass: 266 S-stearoyl-L-cysteine MOD:00816 A protein modification that effectively converts an L-cysteine residue to S-stearoyl-L-cysteine. DeltaMass:0 PubMed:2371783 PubMed:3143715 PubMed:8761467 RESID:AA0407 DiffAvg: 266.47 DiffFormula: C 18 H 34 N 0 O 1 S 0 DiffMono: 266.260966 Formula: C 21 H 39 N 1 O 2 S 1 MassAvg: 369.61 MassMono: 369.270150 Origin: C Source: natural TermSpec: none (R)-2-amino-3-(octadecanoylsulfanyl)propanoic acid 2-amino-3-(octadecanoylthio)propanoic acid LIPID S-stearoyl cysteine S-stearoyl-L-cysteine SSteCys Stearoylation cysteine octadecanoate thioester cysteine stearate thioester A protein modification that effectively converts an L-tryptophan residue to 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0026 (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophan (2S,3aR,8aS)-3a-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan 3'Ger2'N2cycTrp LIPID 3'-geranyl-2',N2-cyclotryptophan PSI-MOD MOD:00817 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan MOD:00817 A protein modification that effectively converts an L-tryptophan residue to 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan. ChEBI:35304 PubMed:16407988 PubMed:8168130 RESID:AA0408 DiffAvg: 136.24 DiffFormula: C 10 H 16 N 0 O 0 DiffMono: 136.125201 Formula: C 21 H 26 N 2 O 1 MassAvg: 322.45 MassMono: 322.204513 Origin: W Source: natural TermSpec: none (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophan (2S,3aR,8aS)-3a-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan 3'Ger2'N2cycTrp LIPID 3'-geranyl-2',N2-cyclotryptophan A protein modification that effectively converts a residue to a glycosylphosphatidylinositolethanolamidated. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0139 GPIRes LIPID GPI-anchor amidated carboxyl end PSI-MOD GPIanchor glycosylphosphatidylinositol MOD:00818 glycosylphosphatidylinositolated residue MOD:00818 A protein modification that effectively converts a residue to a glycosylphosphatidylinositolethanolamidated. PubMed:12643538 Unimod:394#C-term DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: C-term Unimod: Unimod:394 GPIRes LIPID GPI-anchor amidated carboxyl end GPIanchor glycosylphosphatidylinositol A protein modification that effectively converts an L-glutamic acid residue to L-2-aminobutanoic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-aminobutanoic acid Abu L-2-amino-n-butyric acid L-2-aminobutanoic acid L-2-aminobutyric acid L-alpha-amino-n-butyric acid L-alpha-aminobutyric acid L-butyrine alpha-amino-n-butyric acid alpha-aminobutyric acid butyrine dCbxGlu PSI-MOD MOD:00819 L-2-aminobutanoic acid (Glu) MOD:00819 A protein modification that effectively converts an L-glutamic acid residue to L-2-aminobutanoic acid. ChEBI:35619 DeltaMass:0 PubMed:11740505 RESID:AA0409 DiffAvg: -44.01 DiffFormula: C -1 H 0 N 0 O -2 DiffMono: -43.989829 Formula: C 4 H 7 N 1 O 1 MassAvg: 85.11 MassMono: 85.052764 Origin: E Source: natural TermSpec: none (S)-2-aminobutanoic acid Abu Abu L-2-amino-n-butyric acid L-2-aminobutanoic acid L-2-aminobutyric acid L-alpha-amino-n-butyric acid L-alpha-aminobutyric acid L-butyrine alpha-amino-n-butyric acid alpha-aminobutyric acid butyrine dCbxGlu A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue to form 2-imino-alanine 5-imidazolinone glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2-ethanimidoyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2,N-didehydroalanyl-5-imidazolinone glycine 2-(1-iminoethyl)-1-carboxymethyl-1-imidazolin-5-one 2-imino-alanine 5-imidazolinone glycine 2-imino-alanyl-5-imidazolinone glycine [2-(1-iminoethyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid alanyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein zRFP574 chromophore PSI-MOD MOD:00820 Cross-link 2; carboxamidine. 2-imino-alanine 5-imidazolinone glycine MOD:00820 A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue to form 2-imino-alanine 5-imidazolinone glycine. PubMed:16627946 RESID:AA0410 DiffAvg: -64.04 DiffFormula: C -1 H -4 N 0 O -3 DiffMono: -64.016044 Formula: C 5 H 4 N 2 O 1 MassAvg: 108.10 MassMono: 108.032363 Origin: D, G Source: natural TermSpec: none (2-ethanimidoyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid 2,N-didehydroalanyl-5-imidazolinone glycine 2-(1-iminoethyl)-1-carboxymethyl-1-imidazolin-5-one 2-imino-alanine 5-imidazolinone glycine 2-imino-alanyl-5-imidazolinone glycine [2-(1-iminoethyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid alanyl-5-imidazolinone glycine para-hydroxybenzylidene-imidazolidinone chromophore red fluorescent protein zRFP574 chromophore A protein modification that effectively crosslinks an L-alanine residue and an L-cysteine residue by a thioester bond to form S-(L-alanyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-([(2S)-2-aminopropanoyl]sulfanyl)propanoic acid CROSSLNK Alanyl cysteine thioester (Cys-Ala) S-(2-aminopropanoyl)cysteine S-(L-alanyl)-L-cysteine XLNK1AlaSCys alanine cysteine thioester PSI-MOD MOD:00821 Cross-link 2. S-(L-alanyl)-L-cysteine MOD:00821 A protein modification that effectively crosslinks an L-alanine residue and an L-cysteine residue by a thioester bond to form S-(L-alanyl)-L-cysteine. PubMed:11807079 RESID:AA0411 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 6 H 9 N 2 O 2 S 1 MassAvg: 173.21 MassMono: 173.038474 Origin: A, C Source: hypothetical TermSpec: C-term (2R)-2-amino-3-([(2S)-2-aminopropanoyl]sulfanyl)propanoic acid CROSSLNK Alanyl cysteine thioester (Cys-Ala) S-(2-aminopropanoyl)cysteine S-(L-alanyl)-L-cysteine XLNK1AlaSCys alanine cysteine thioester A protein modification that effectively crosslinks an L-leucine residue and an L-cysteine residue by a thioester bond to form S-(L-leucyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-([(2S)-2-amino-4-methylpentanoyl]sulfanyl)propanoic acid CROSSLNK Leucyl cysteine thioester (Cys-Leu) S-(2-amino-4-methylpentanoyl)cysteine S-(L-leucyl)-L-cysteine XLNK1LeuSCys leucine cysteine thioester PSI-MOD MOD:00822 Cross-link 2. S-(L-leucyl)-L-cysteine MOD:00822 A protein modification that effectively crosslinks an L-leucine residue and an L-cysteine residue by a thioester bond to form S-(L-leucyl)-L-cysteine. PubMed:12591958 RESID:AA0412 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 9 H 15 N 2 O 2 S 1 MassAvg: 215.29 MassMono: 215.085424 Origin: C, L Source: natural TermSpec: C-term (2R)-2-amino-3-([(2S)-2-amino-4-methylpentanoyl]sulfanyl)propanoic acid CROSSLNK Leucyl cysteine thioester (Cys-Leu) S-(2-amino-4-methylpentanoyl)cysteine S-(L-leucyl)-L-cysteine XLNK1LeuSCys leucine cysteine thioester A protein modification that effectively crosslinks an L-methionine residue and an L-cysteine residue by a thioester bond to form S-(L-methionyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-([(2S)-2-amino-4-(methylsulfanyl)butanoyl]sulfanyl)propanoic acid CROSSLNK Methionyl cysteine thioester (Cys-Met) S-(2-amino-4-methylthiobutanoyl)cysteine S-(L-methionyl)-L-cysteine XLNK1MetSCys methionine cysteine thioester PSI-MOD MOD:00823 Cross-link 2. S-(L-methionyl)-L-cysteine MOD:00823 A protein modification that effectively crosslinks an L-methionine residue and an L-cysteine residue by a thioester bond to form S-(L-methionyl)-L-cysteine. PubMed:12146974 RESID:AA0413 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 8 H 13 N 2 O 2 S 2 MassAvg: 233.32 MassMono: 233.041845 Origin: C, M Source: natural TermSpec: C-term (2R)-2-amino-3-([(2S)-2-amino-4-(methylsulfanyl)butanoyl]sulfanyl)propanoic acid CROSSLNK Methionyl cysteine thioester (Cys-Met) S-(2-amino-4-methylthiobutanoyl)cysteine S-(L-methionyl)-L-cysteine XLNK1MetSCys methionine cysteine thioester A protein modification that effectively converts an L-tyrosine residue to dehydroalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0647 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dha anhydroserine dHAla(Tyr) dehydroalanine PSI-MOD MOD:00824 incidental to RESID:AA0178 dehydroalanine (Tyr) MOD:00824 A protein modification that effectively converts an L-tyrosine residue to dehydroalanine. PubMed:10220322 PubMed:1547888 PubMed:1815586 PubMed:2914619 PubMed:6838602 PubMed:7947813 PubMed:8239649 RESID:AA0181#TYR Unimod:400 DiffAvg: -94.11 DiffFormula: C -6 H -6 N 0 O -1 DiffMono: -94.041865 Formula: C 3 H 3 N 1 O 1 MassAvg: 69.06 MassMono: 69.021464 Origin: Y Source: natural TermSpec: none Unimod: Unimod:400 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dha anhydroserine dHAla(Tyr) dehydroalanine A protein modification that effectively crosslinks an L-phenylalanine residue and an L-cysteine residue by a thioester bond to form S-(L-phenylalaninyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]sulfanyl)propanoic acid CROSSLNK Phenylalanyl cysteine thioester (Cys-Phe) S-(2-amino-3-phenylpropanoyl)cysteine S-(L-phenylalanyl)-L-cysteine XLNK1PheSCys phenylalanine cysteine thioester PSI-MOD MOD:00825 Cross-link 2. S-(L-phenylalanyl)-L-cysteine MOD:00825 A protein modification that effectively crosslinks an L-phenylalanine residue and an L-cysteine residue by a thioester bond to form S-(L-phenylalaninyl)-L-cysteine. PubMed:12591958 RESID:AA0414 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 12 H 13 N 2 O 2 S 1 MassAvg: 249.31 MassMono: 249.069774 Origin: C, F Source: natural TermSpec: C-term (2R)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]sulfanyl)propanoic acid CROSSLNK Phenylalanyl cysteine thioester (Cys-Phe) S-(2-amino-3-phenylpropanoyl)cysteine S-(L-phenylalanyl)-L-cysteine XLNK1PheSCys phenylalanine cysteine thioester A protein modification that effectively crosslinks an L-threonine residue and an L-cysteine residue by a thioester bond to form S-(L-threonyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-([(2S,3R)-2-amino-3-hydroxybutanoyl]sulfanyl)propanoic acid CROSSLNK Threonyl cysteine thioester (Cys-Thr) S-(2-amino-3-hydroxybutanoyl)cysteine S-(L-threonyl)-L-cysteine XLNK1ThrSCys threonine cysteine thioester PSI-MOD MOD:00826 Cross-link 2. S-(L-threonyl)-L-cysteine MOD:00826 A protein modification that effectively crosslinks an L-threonine residue and an L-cysteine residue by a thioester bond to form S-(L-threonyl)-L-cysteine. PubMed:15268951 RESID:AA0415 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 7 H 11 N 2 O 3 S 1 MassAvg: 203.24 MassMono: 203.049038 Origin: C, T Source: natural TermSpec: C-term (2R)-2-amino-3-([(2S,3R)-2-amino-3-hydroxybutanoyl]sulfanyl)propanoic acid CROSSLNK Threonyl cysteine thioester (Cys-Thr) S-(2-amino-3-hydroxybutanoyl)cysteine S-(L-threonyl)-L-cysteine XLNK1ThrSCys threonine cysteine thioester A protein modification that effectively crosslinks an L-tyrosine residue and an L-cysteine residue by a thioester bond to form S-(L-tyrosyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-([(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfanyl)propanoic acid CROSSLNK Tyrosyl cysteine thioester (Cys-Tyr) S-(L-tyrosyl)-L-cysteine S-[2-amino-3-(4-hydoxyphenyl)propanoyl]cysteine XLNK1TyrSCys tyrosine cysteine thioester PSI-MOD MOD:00827 Cross-link 2. S-(L-tyrosyl)-L-cysteine MOD:00827 A protein modification that effectively crosslinks an L-tyrosine residue and an L-cysteine residue by a thioester bond to form S-(L-tyrosyl)-L-cysteine. PubMed:11807079 RESID:AA0416 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 12 H 13 N 2 O 3 S 1 MassAvg: 265.31 MassMono: 265.064688 Origin: C, Y Source: natural TermSpec: C-term (2R)-2-amino-3-([(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfanyl)propanoic acid CROSSLNK Tyrosyl cysteine thioester (Cys-Tyr) S-(L-tyrosyl)-L-cysteine S-[2-amino-3-(4-hydoxyphenyl)propanoyl]cysteine XLNK1TyrSCys tyrosine cysteine thioester A protein modification that effectively crosslinks an L-tryptophan residue and an L-cysteine residue by a thioester bond to form S-(L-tryptophanyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-([(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]sulfanyl)propanoic acid CROSSLNK Tryptophanyl cysteine thioester (Cys-Trp) S-(L-tryptophanyl)-L-cysteine S-[2-amino-3-(1H-indol-3-yl)propanoyl]cysteine XLNK1TrpSCys tryptophan cysteine thioester PSI-MOD MOD:00828 Cross-link 2. S-(L-tryptophanyl)-L-cysteine MOD:00828 A protein modification that effectively crosslinks an L-tryptophan residue and an L-cysteine residue by a thioester bond to form S-(L-tryptophanyl)-L-cysteine. PubMed:16030216 RESID:AA0417 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 14 H 14 N 3 O 2 S 1 MassAvg: 288.35 MassMono: 288.080673 Origin: C, W Source: natural TermSpec: C-term (2R)-2-amino-3-([(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]sulfanyl)propanoic acid CROSSLNK Tryptophanyl cysteine thioester (Cys-Trp) S-(L-tryptophanyl)-L-cysteine S-[2-amino-3-(1H-indol-3-yl)propanoyl]cysteine XLNK1TrpSCys tryptophan cysteine thioester A protein modification that effectively crosslinks an L-phenylalanine residue and an L-serine residue by an ester bond to form S-(L-phenylalaninyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]oxy)propanoic acid CROSSLNK Phenylalanyl serine ester (Ser-Phe) O-(2-amino-3-phenylpropanoyl)serine O-(L-phenylalanyl)-L-serine XLNK1PheOSer phenylalanine serine ester PSI-MOD MOD:00829 Cross-link 2. O-(L-phenylalanyl)-L-serine MOD:00829 A protein modification that effectively crosslinks an L-phenylalanine residue and an L-serine residue by an ester bond to form S-(L-phenylalaninyl)-L-serine. PubMed:12591958 RESID:AA0418 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 12 H 13 N 2 O 3 MassAvg: 233.25 MassMono: 233.092617 Origin: F, S Source: natural TermSpec: C-term (2S)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]oxy)propanoic acid CROSSLNK Phenylalanyl serine ester (Ser-Phe) O-(2-amino-3-phenylpropanoyl)serine O-(L-phenylalanyl)-L-serine XLNK1PheOSer phenylalanine serine ester A protein modification that effectively converts an L-proline residue to an N-methyl-L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0219 (S)-1-methylpyrrolidine-2-carboxylic acid 1-methylpyrrolidine-2-carboxylic acid MOD_RES N-methylproline N-methyl-L-proline N-methylated L-proline NMePro hygric acid PSI-MOD MOD:00830 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-proline MOD:00830 A protein modification that effectively converts an L-proline residue to an N-methyl-L-proline. PubMed:3127388 RESID:AA0419 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 6 H 10 N 1 O 1 MassAvg: 112.15 MassMono: 112.076239 Origin: P Source: natural TermSpec: N-term (S)-1-methylpyrrolidine-2-carboxylic acid 1-methylpyrrolidine-2-carboxylic acid MOD_RES N-methylproline N-methyl-L-proline N-methylated L-proline NMePro hygric acid A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0527 CARBOHYD N-linked (GlcNAc) asparagine N4GlcNAcAsn PSI-MOD HexNAc MOD:00831 N4-(N-acetylamino)glucosyl-L-asparagine MOD:00831 A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine. PubMed:111247 PubMed:1694179 PubMed:5490222 RESID:AA0151#var DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 12 H 19 N 3 O 7 MassAvg: 317.30 MassMono: 317.122300 Origin: N Source: natural TermSpec: none CARBOHYD N-linked (GlcNAc) asparagine N4GlcNAcAsn HexNAc A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminogalactosyl)-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0512 (2S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid CARBOHYD N-linked (GalNAc) asparagine N4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-L-asparagine N4-(2-acetylamino-2-deoxy-beta-D-galactopyranosyl)-L-asparagine N4-(N-acetylamino)galactosyl-L-asparagine N4-(N-acetylgalactosaminyl)asparagine N4-asparagine-beta-N-acetylgalactosaminide N4-glycosyl-L-asparagine N4-glycosylasparagine N4GalNAcAsn PSI-MOD HexNAc MOD:00832 N4-(N-acetylamino)galactosyl-L-asparagine MOD:00832 A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminogalactosyl)-L-asparagine. PubMed:8262914 RESID:AA0420 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 12 H 19 N 3 O 7 MassAvg: 317.30 MassMono: 317.122300 Origin: N Source: natural TermSpec: none (2S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid CARBOHYD N-linked (GalNAc) asparagine N4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-L-asparagine N4-(2-acetylamino-2-deoxy-beta-D-galactopyranosyl)-L-asparagine N4-(N-acetylamino)galactosyl-L-asparagine N4-(N-acetylgalactosaminyl)asparagine N4-asparagine-beta-N-acetylgalactosaminide N4-glycosyl-L-asparagine N4-glycosylasparagine N4GalNAcAsn HexNAc A protein modification that effectively converts an L-asparagine residue to N4-glucosyl-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0517 (2S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid CARBOHYD N-linked (Glc) CARBOHYD N-linked (Glc) asparagine N4-(D-glucopyranosyl)-L-asparagine N4-asparagine-glucoside N4-glucosyl-L-asparagine N4-glucosylasparagine N4-glycosyl-L-asparagine N4-glycosylasparagine N4GlcAsn PSI-MOD MOD:00833 N4-glucosyl-L-asparagine MOD:00833 A protein modification that effectively converts an L-asparagine residue to N4-glucosyl-asparagine. PubMed:1569073 PubMed:3410849 RESID:AA0421 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 10 H 16 N 2 O 7 MassAvg: 276.25 MassMono: 276.095751 Origin: N Source: natural TermSpec: none (2S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid CARBOHYD N-linked (Glc) CARBOHYD N-linked (Glc) asparagine N4-(D-glucopyranosyl)-L-asparagine N4-asparagine-glucoside N4-glucosyl-L-asparagine N4-glucosylasparagine N4-glycosyl-L-asparagine N4-glycosylasparagine N4GlcAsn A protein modification that effectively converts an L-serine residue to O3-(N-acetamino)fucosylserine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0553 (2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-fucopyranosyloxy)propanoic acid CARBOHYD O-linked (FucNAc) serine O-(2-acetylamino-2-deoxy-beta-D-fucopyranosyl)-L-serine O-(N-acetylamino)fucosyl-L-serine O-(N-acetylfucosaminyl)serine O-seryl-beta-N-acetylfucosaminide O3-(2-acetamido-2-deoxy-beta-D-fucopyranosyl)-L-serine O3-(N-acetylfucosaminyl)serine OFucNAcSer PSI-MOD MOD:00834 O-(N-acetylamino)fucosyl-L-serine MOD:00834 A protein modification that effectively converts an L-serine residue to O3-(N-acetamino)fucosylserine. PubMed:11342554 PubMed:12010970 RESID:AA0422 DiffAvg: 187.19 DiffFormula: C 8 H 13 N 1 O 4 DiffMono: 187.084458 Formula: C 11 H 18 N 2 O 6 MassAvg: 274.27 MassMono: 274.116486 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-fucopyranosyloxy)propanoic acid CARBOHYD O-linked (FucNAc) serine O-(2-acetylamino-2-deoxy-beta-D-fucopyranosyl)-L-serine O-(N-acetylamino)fucosyl-L-serine O-(N-acetylfucosaminyl)serine O-seryl-beta-N-acetylfucosaminide O3-(2-acetamido-2-deoxy-beta-D-fucopyranosyl)-L-serine O3-(N-acetylfucosaminyl)serine OFucNAcSer A protein modification that effectively converts an L-serine residue to L-oxoalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (S)-2-amino-3-oxopropanoic acid 2-amino-3-oxopropionic acid L-3-oxoalanine L-amino-malonic acid semialdehyde L-aminomalonaldehydic acid MOD_RES 3-oxoalanine (Ser) formylglycine (from serine) PSI-MOD C(alpha)-formylglycine Didehydro L-serinesemialdehyde dehydrogenated serine residue formylglycine oxoalanine MOD:00835 L-3-oxoalanine (Ser) MOD:00835 A protein modification that effectively converts an L-serine residue to L-oxoalanine. DeltaMass:349 PubMed:14563551 PubMed:7628016 PubMed:8681943 PubMed:9276974 PubMed:9478923 RESID:AA0185#SER Unimod:401#S DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 3 H 3 N 1 O 2 MassAvg: 85.06 MassMono: 85.016378 Origin: S Source: natural TermSpec: none Unimod: Unimod:401 (S)-2-amino-3-oxopropanoic acid 2-amino-3-oxopropionic acid L-3-oxoalanine L-amino-malonic acid semialdehyde L-aminomalonaldehydic acid MOD_RES 3-oxoalanine (Ser) formylglycine (from serine) C(alpha)-formylglycine Didehydro L-serinesemialdehyde dehydrogenated serine residue formylglycine oxoalanine A protein modification that effectively substitutes two (2)H deuterium atoms for two (1)H protium atoms. D(H)2Res PSI-MOD MOD:00836 deuterium disubstituted residue MOD:00836 A protein modification that effectively substitutes two (2)H deuterium atoms for two (1)H protium atoms. PubMed:18688235 D(H)2Res A protein modification that effectively substitutes four (2)H deuterium atoms for four (1)H protium atoms. D(H)4Res PSI-MOD MOD:00837 deuterium tetrasubstituted residue MOD:00837 A protein modification that effectively substitutes four (2)H deuterium atoms for four (1)H protium atoms. PubMed:18688235 D(H)4Res A protein modification that effectively substitutes three (1)H protium atoms with three (2)H deuterium atoms to produce 3x(2)H labeled L-leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: D(H)3Leu PSI-MOD Label:2H(3) Trideuteration MOD:00838 3x(2)H labeled L-leucine MOD:00838 A protein modification that effectively substitutes three (1)H protium atoms with three (2)H deuterium atoms to produce 3x(2)H labeled L-leucine. Unimod:262#L DiffAvg: 3.02 DiffFormula: (1)H -3 (2)H 3 DiffMono: 3.018830 Formula: C 6 (1)H 8 (2)H 3 N 1 O 1 MassAvg: 116.10 MassMono: 116.102894 Origin: L Source: artifact TermSpec: none Unimod: Unimod:262 D(H)3Leu Label:2H(3) Trideuteration A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing deuteriumm, (2)H. PSI-MOD MOD:00839 (2)H deuterium labeled residue MOD:00839 A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing deuteriumm, (2)H. PubMed:18688235 A protein modification produced by formation of an adduct with an isocyanate compound. PSI-MOD MOD:00840 isocyanate reagent derivatized residue MOD:00840 A protein modification produced by formation of an adduct with an isocyanate compound. PubMed:18688235 A protein modification produced by formation of an adduct with an isothiocyanate compound. PSI-MOD MOD:00841 isothiocyanate reagent derivatized residue MOD:00841 A protein modification produced by formation of an adduct with an isothiocyanate compound. PubMed:18688235 A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (13)C. PSI-MOD MOD:00842 (13)C labeled residue MOD:00842 A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (13)C. PubMed:18688235 A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (15)N. PSI-MOD MOD:00843 (15)N labeled residue MOD:00843 A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (15)N. PubMed:18688235 A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (18)O. PSI-MOD MOD:00844 (18)O labeled residue MOD:00844 A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (18)O. PubMed:18688235 A protein modification that effectively substitutes one or more (18)O atoms for (16)O atoms. PSI-MOD MOD:00845 (18)O substituted residue MOD:00845 A protein modification that effectively substitutes one or more (18)O atoms for (16)O atoms. PubMed:18688235 stub PSI-MOD MOD:00846 levuglandinyl (prostaglandin H2) adduct MOD:00846 stub PubMed:18688235 A protein modification that effectively substitutes two (18)O atom for two (16)O atoms. PSI-MOD MOD:00847 (18)O disubstituted residue MOD:00847 A protein modification that effectively substitutes two (18)O atom for two (16)O atoms. PubMed:18688235 A protein modification that is produced by formation of an adduct with a particular compound used as a reagent. PSI-MOD MOD:00848 reagent derivatized residue MOD:00848 A protein modification that is produced by formation of an adduct with a particular compound used as a reagent. PubMed:18688235 A protein modification that effectively substitutes a potassium atom for a hydrogen atom. KRes PSI-MOD MOD:00849 potassium containing modified residue MOD:00849 A protein modification that effectively substitutes a potassium atom for a hydrogen atom. PubMed:18688235 KRes A protein modification that inserts or replaces a residue with an unnatural residue that is not considered to be derived from a natural residue by some chemical process. PSI-MOD MOD:00850 unnatural residue MOD:00850 A protein modification that inserts or replaces a residue with an unnatural residue that is not considered to be derived from a natural residue by some chemical process. PubMed:18688235 A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with (18)O. Origin: Source: TermSpec: PSI-MOD MOD:00851 (18)O labeled deamidated residue MOD:00851 A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with (18)O. PubMed:18688235 Origin: X Source: artifact TermSpec: none A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with one (18)O. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:00852 1x(18)O labeled deamidated residue MOD:00852 A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with one (18)O. PubMed:8382902 Unimod:366 DiffAvg: 2.99 DiffFormula: H -1 N -1 (18)O 1 DiffMono: 2.988262 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:366 A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with two (18)O. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00853 2x(18)O labeled deamidated residue MOD:00853 A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with two (18)O. PubMed:18688235 DiffAvg: 4.99 DiffFormula: H -1 N -1 (16)O -1 (18)O 2 DiffMono: 4.992508 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none A protein modification that effectively converts an L-lysine to L-lysinium (protonated L-lysine). DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00854 Some sources compute the difference formula for charged, quatenary modified lysine based on protonated lysine rather than neutral lysine residue. In such cases, a comparable difference formula can be calculated based on this derivative. protonated L-lysine (L-lysinium) residue MOD:00854 A protein modification that effectively converts an L-lysine to L-lysinium (protonated L-lysine). PubMed:18688235 DiffAvg: 1.01 DiffFormula: C 0 H 1 N 0 O 0 DiffMono: 1.007276 FormalCharge: 1+ Formula: C 6 H 13 N 2 O 1 MassAvg: 129.18 MassMono: 129.102239 Origin: K Source: natural TermSpec: none A protein modification that effectively converts an L-lysinium (N6-protonated L-lysine) residue to an N6,N6,N6-trimethyl-L-lysine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N6Me3Lys trimethylk PSI-MOD MOD:00855 For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N6Me3+Lys process (MOD:00083) accounts for both protonation and trimethylation. N6,N6,N6-trimethyl-L-lysine (from L-lysinium residue) MOD:00855 A protein modification that effectively converts an L-lysinium (N6-protonated L-lysine) residue to an N6,N6,N6-trimethyl-L-lysine. DeltaMass:0 OMSSA:15 PubMed:12590383 PubMed:3145979 PubMed:4304194 PubMed:6778808 PubMed:7093227 PubMed:8453381 Unimod:37#K DiffAvg: 42.08 DiffFormula: C 3 H 6 N 0 O 0 DiffMono: 42.046402 FormalCharge: 1+ Formula: C 9 H 19 N 2 O 1 MassAvg: 171.26 MassMono: 171.149190 Origin: MOD:00854 Source: natural TermSpec: none Unimod: Unimod:37 N6Me3Lys trimethylk A protein modification that effectively converts an L-alanine residue to an L-alaninium (protonated L-alanine). DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00856 protonated L-alanine (L-alaninium) residue MOD:00856 A protein modification that effectively converts an L-alanine residue to an L-alaninium (protonated L-alanine). PubMed:18688235 DiffAvg: 1.01 DiffFormula: C 0 H 1 N 0 O 0 DiffMono: 1.007276 FormalCharge: 1+ Formula: C 3 H 7 N 1 O 1 MassAvg: 73.09 MassMono: 73.052215 Origin: A Source: natural TermSpec: N-term A protein modification that effectively converts an L-alaninium (protonated L-alanine) residue to an N,N,N-trimethyl-L-alanine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N2Me3Ala PSI-MOD MOD:00857 For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ala process (MOD:00071) accounts for both protonation and trimethylation. N,N,N-trimethyl-L-alanine (from L-alaninium) MOD:00857 A protein modification that effectively converts an L-alaninium (protonated L-alanine) residue to an N,N,N-trimethyl-L-alanine. PubMed:12590383 PubMed:332162 PubMed:3979397 PubMed:6778808 PubMed:7715456 Unimod:37#A DiffAvg: 42.08 DiffFormula: C 3 H 6 N 0 O 0 DiffMono: 42.046402 FormalCharge: 1+ Formula: C 6 H 13 N 1 O 1 MassAvg: 115.18 MassMono: 115.099165 Origin: MOD:00856 Source: natural TermSpec: N-term Unimod: Unimod:37 N2Me3Ala A protein modification that effectively converts an L-serine residue to D-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0113 (R)-2-aminopropanoic acid D-Ala(Ser) D-alanine MOD_RES D-alanine (Ser) PSI-MOD MOD:00858 D-alanine (Ser) MOD:00858 A protein modification that effectively converts an L-serine residue to D-alanine. PubMed:7961627 RESID:AA0191#SER DiffAvg: -16.00 DiffFormula: C 0 H 0 N 0 O -1 DiffMono: -15.994915 Formula: C 3 H 5 N 1 O 1 MassAvg: 71.08 MassMono: 71.037114 Origin: S Source: natural TermSpec: none (R)-2-aminopropanoic acid D-Ala(Ser) D-alanine MOD_RES D-alanine (Ser) A protein modification that can be derived from different natural residues by different chemical processes. Origin: Source: TermSpec: PSI-MOD MOD:00859 modified residue that can arise from different natural residues MOD:00859 A protein modification that can be derived from different natural residues by different chemical processes. PubMed:18688235 Origin: X Source: natural TermSpec: none A protein modification that produces an amino acid residue containing an exogenous sulfur atom. PSI-MOD MOD:00860 sulfur containing modified residue MOD:00860 A protein modification that produces an amino acid residue containing an exogenous sulfur atom. PubMed:18688235 A protein modification that produces an amino acid residue containing a phosphorus atom. PSI-MOD MOD:00861 phosphorus containing modified residue MOD:00861 A protein modification that produces an amino acid residue containing a phosphorus atom. PubMed:18688235 A protein modification that effectively converts a source amino acid residue to D-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (R)-2-aminopropanoic acid D-alanine MOD_RES D-alanine (Ala) MOD_RES D-alanine (Ser) PSI-MOD MOD:00862 D-alanine MOD:00862 A protein modification that effectively converts a source amino acid residue to D-alanine. ChEBI:29949 PubMed:7287302 PubMed:7961627 RESID:AA0191 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 3 H 5 N 1 O 1 MassAvg: 71.08 MassMono: 71.037114 Origin: X Source: natural TermSpec: none (R)-2-aminopropanoic acid D-alanine MOD_RES D-alanine (Ala) MOD_RES D-alanine (Ser) A protein modification that effectively converts an L-threonine residue to D-allo-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0310 (2R,3R)-2-amino-3-hydroxybutanoic acid D-Thr D-threonine MOD_RES D-threonine PSI-MOD MOD:00863 D-allo-threonine MOD:00863 A protein modification that effectively converts an L-threonine residue to D-allo-threonine. ChEBI:32826 PubMed:18025465 PubMed:6893271 RESID:AA0199 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 4 H 7 N 1 O 2 MassAvg: 101.10 MassMono: 101.047678 Origin: T Source: natural TermSpec: none (2R,3R)-2-amino-3-hydroxybutanoic acid D-Thr D-threonine MOD_RES D-threonine A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-histidino diiron disulfide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: CDGSH domain iron-sulfur cluster METAL Iron-sulfur (2Fe-2S) METAL Iron-sulfur (2Fe-2S); via pros nitrogen di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-N3'-histidinoiron) tris-L-cysteinyl L-histidino diiron disulfide PSI-MOD MOD:00864 Cross-link 4. tris-L-cysteinyl L-histidino diiron disulfide MOD:00864 A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-histidino diiron disulfide. PubMed:17766439 PubMed:17766440 RESID:AA0438 DiffAvg: 171.78 DiffFormula: C 0 Fe 2 H -4 N 0 O 0 S 2 DiffMono: 171.783814 FormalCharge: 2- Formula: C 15 Fe 2 H 18 N 6 O 4 S 5 MassAvg: 618.34 MassMono: 617.870280 Origin: C, C, C, H Source: natural TermSpec: none CDGSH domain iron-sulfur cluster METAL Iron-sulfur (2Fe-2S) METAL Iron-sulfur (2Fe-2S); via pros nitrogen di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-N3'-histidinoiron) tris-L-cysteinyl L-histidino diiron disulfide A protein modification that effectively converts an L-aspartic acid residue to N-aspartyl-glycosylsphingolipidinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0322 GSIAsp LIPID GPI-like-anchor amidated aspartate N-aspartyl-glycosylsphingolipidinositolethanolamine PSI-MOD MOD:00865 N-aspartyl-glycosylsphingolipidinositolethanolamine MOD:00865 A protein modification that effectively converts an L-aspartic acid residue to N-aspartyl-glycosylsphingolipidinositolethanolamine. RESID:AA0439 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 6 H 12 N 2 O 7 P 1 MassAvg: 255.14 MassMono: 255.038212 Origin: D Source: hypothetical TermSpec: C-term GSIAsp LIPID GPI-like-anchor amidated aspartate N-aspartyl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts an L-proline residue to one of several dihydroxylated proline residues, such as (2S,3R,4R)-3,4-dihydroxyproline or (2S,3R,4S)-3,4-dihydroxyproline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0024 Hy2Pro PSI-MOD MOD:00866 dihydroxylated proline MOD:00866 A protein modification that effectively converts an L-proline residue to one of several dihydroxylated proline residues, such as (2S,3R,4R)-3,4-dihydroxyproline or (2S,3R,4S)-3,4-dihydroxyproline. PubMed:18688235 DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: P Source: natural TermSpec: none Hy2Pro A protein modification that effectively cross-links an L-cysteine residue and an L-cysteine converted to an L-selenocysteine residue to form L-cysteinyl-L-selenocystine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid CROSSLNK Cysteinyl-selenocysteine (Cys-Sec) CROSSLNK Cysteinyl-selenocysteine (Sec-Cys) L-cysteinyl-L-selenocysteine PSI-MOD MOD:00867 Cross-link 2. L-cysteinyl-L-selenocysteine (Cys-Cys) MOD:00867 A protein modification that effectively cross-links an L-cysteine residue and an L-cysteine converted to an L-selenocysteine residue to form L-cysteinyl-L-selenocystine. PubMed:10801974 PubMed:12911312 PubMed:17177418 RESID:AA0358#CYS DiffAvg: 44.90 DiffFormula: C 0 H -2 N 0 O 0 S -1 Se 1 DiffMono: 45.928800 Formula: C 6 H 8 N 2 O 2 S 1 Se 1 MassAvg: 251.17 MassMono: 251.947170 Origin: C, C Source: natural TermSpec: none (R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid CROSSLNK Cysteinyl-selenocysteine (Cys-Sec) CROSSLNK Cysteinyl-selenocysteine (Sec-Cys) L-cysteinyl-L-selenocysteine A protein modification that inserts or replaces a residue with a natural, non-standard encoded residue, such as N-formyl-L-methionine, L-selenocysteine, or L-pyrrolysine. Origin: Source: PSI-MOD MOD:00868 These are produced exclusively by modification of amino acids acylated to special tRNA before incorporation by ribosomes into proteins. For this reason, they have also been referred to as pre-translational modifications. natural, non-standard encoded residue MOD:00868 A protein modification that inserts or replaces a residue with a natural, non-standard encoded residue, such as N-formyl-L-methionine, L-selenocysteine, or L-pyrrolysine. PubMed:18688235 Origin: X Source: natural A protein modification that effectively converts an L-aspartic acid residue to L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0314 (2S)-2-aminopropanoic acid 2-aminopropionic acid 2-azanylpropanoic acid Asp(Ala) L-alanine MOD_RES Beta-decarboxylated aspartate alpha-alanine alpha-aminopropionic acid PSI-MOD MOD:00869 This has been reported to occur by a natural process of beta-decarboxylation. L-alanine residue (Asp) MOD:00869 A protein modification that effectively converts an L-aspartic acid residue to L-alanine. PubMed:17138938 RESID:AA0001#ASP DiffAvg: -44.01 DiffFormula: C -1 H 0 N 0 O -2 DiffMono: -43.989829 Formula: C 3 H 5 N 1 O 1 MassAvg: 71.08 MassMono: 71.037114 Origin: D Source: natural TermSpec: none (2S)-2-aminopropanoic acid 2-aminopropionic acid 2-azanylpropanoic acid Asp(Ala) L-alanine MOD_RES Beta-decarboxylated aspartate alpha-alanine alpha-aminopropionic acid A protein modification produced by formation of an adduct with phenyl isocyanate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Phenylisocyanate phenyl isocyanate MOD:00870 From Unimod with no citation. phenyl isocyanate derivatized residue MOD:00870 A protein modification produced by formation of an adduct with phenyl isocyanate. Unimod:411 DiffAvg: 119.12 DiffFormula: C 7 H 5 N 1 O 1 DiffMono: 119.037114 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:411 Phenylisocyanate phenyl isocyanate A protein modification produced by formation of an adduct with (2)H5-phenyl isocyanate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Phenylisocyanate:2H(5) d5-phenyl isocyanate MOD:00871 From Unimod with no citation. (2)H5-phenyl isocyanate derivatized residue MOD:00871 A protein modification produced by formation of an adduct with (2)H5-phenyl isocyanate. Unimod:412 DiffAvg: 124.07 DiffFormula: C 7 (2)H 5 N 1 O 1 DiffMono: 124.068498 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:412 Phenylisocyanate:2H(5) d5-phenyl isocyanate OBSOLETE because redundant and identical to MOD:01970. Remap to MOD:01970. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: N alpha -(gamma-Glutamyl)-Glu PSI-MOD Glu monoglutamyl MOD:00872 L-isoglutamyl monoglutamic acid true MOD:00872 OBSOLETE because redundant and identical to MOD:01970. Remap to MOD:01970. PubMed:10747868 PubMed:15525938 PubMed:1680872 RESID:AA0202#var Unimod:450 DiffAvg: 129.12 DiffFormula: C 5 H 7 N 1 O 3 DiffMono: 129.042593 Formula: C 10 H 14 N 2 O 6 MassAvg: 258.23 MassMono: 258.085186 Origin: E Remap: MOD:01970 Source: natural TermSpec: none Unimod: Unimod:450 N alpha -(gamma-Glutamyl)-Glu Glu monoglutamyl A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamic acid, forming an isopeptide bond with a diglutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GluGlu diglutamyl MOD:00873 L-isoglutamyl diglutamic acid MOD:00873 A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamic acid, forming an isopeptide bond with a diglutamic acid. DeltaMass:0 PubMed:10747868 PubMed:1680872 RESID:AA0202#var Unimod:451 DiffAvg: 258.23 DiffFormula: C 10 H 14 N 2 O 6 DiffMono: 258.085186 Formula: C 15 H 21 N 3 O 9 MassAvg: 387.35 MassMono: 387.127779 Origin: E Source: natural TermSpec: none Unimod: Unimod:451 GluGlu diglutamyl A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a triglutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N alpha -(gamma-Glutamyl)-Glu3 PSI-MOD GluGluGlu triglutamyl MOD:00874 From DeltaMass: Average Mass: 388. L-isoglutamyl triglutamic acid MOD:00874 A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a triglutamic acid. DeltaMass:0 PubMed:10747868 PubMed:1680872 RESID:AA0202#var Unimod:452 DiffAvg: 387.35 DiffFormula: C 15 H 21 N 3 O 9 DiffMono: 387.127779 Formula: C 20 H 28 N 4 O 12 MassAvg: 516.46 MassMono: 516.170372 Origin: E Source: natural TermSpec: none Unimod: Unimod:452 N alpha -(gamma-Glutamyl)-Glu3 GluGluGlu triglutamyl A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a tetraglutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GluGluGluGlu tetraglutamyl MOD:00875 L-isoglutamyl tetraglutamic acid MOD:00875 A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a tetraglutamic acid. PubMed:10747868 PubMed:1680872 RESID:AA0202#var Unimod:453 DiffAvg: 516.46 DiffFormula: C 20 H 28 N 4 O 12 DiffMono: 516.170372 Formula: C 25 H 35 N 5 O 15 MassAvg: 645.57 MassMono: 645.212965 Origin: E Source: natural TermSpec: none Unimod: Unimod:453 GluGluGluGlu tetraglutamyl A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosamine sugar group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Hexosamines (GalN, GlcN) PSI-MOD HexN Hexosamine MOD:00876 hexosaminylated residue MOD:00876 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosamine sugar group through a glycosidic bond. Unimod:454 DiffAvg: 161.16 DiffFormula: C 6 H 11 N 1 O 4 DiffMono: 161.068808 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:454 Hexosamines (GalN, GlcN) HexN Hexosamine dimethyl pimelimidate modification from Unimod DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD One end of crosslink attached, one end free Xlink:DMP-s MOD:00877 imidoester crosslink dimethyl pimelimidate singly attached MOD:00877 dimethyl pimelimidate modification from Unimod URL:http://www.piercenet.com/files/0668ss5.pdf Unimod:455 DiffAvg: 154.21 DiffFormula: C 8 H 14 N 2 O 1 DiffMono: 154.110613 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:455 One end of crosslink attached, one end free Xlink:DMP-s dimethyl pimelimidate modification from Unimod - Mechanism of the reaction of imidoesters with amines DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Both ends of crosslink attached to same peptide Xlink:DMP MOD:00878 imidoester crosslink dimethyl pimelimidate doubly attached MOD:00878 dimethyl pimelimidate modification from Unimod - Mechanism of the reaction of imidoesters with amines PubMed:7171546 URL:http://dx.doi.org/10.1021/ja00877a017 Unimod:456 DiffAvg: 122.17 DiffFormula: C 7 H 10 N 2 DiffMono: 122.084398 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:456 Both ends of crosslink attached to same peptide Xlink:DMP modification from Unimod DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD NDA naphthalene-2,3-dicarboxaldehyde MOD:00879 naphthalene-2,3-dicarboxaldehyde MOD:00879 modification from Unimod PubMed:2081203 Unimod:457 DiffAvg: 175.19 DiffFormula: C 13 H 5 N 1 DiffMono: 175.042199 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:457 NDA naphthalene-2,3-dicarboxaldehyde A protein modification produced by formation of an adduct with 6x(13)C labeled 4-sulfophenyl isothiocyanate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 4-sulfophenyl isothiocyanate (Heavy C13) SPITC:13C(6) MOD:00880 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue MOD:00880 A protein modification produced by formation of an adduct with 6x(13)C labeled 4-sulfophenyl isothiocyanate. PubMed:15536630 PubMed:16526082 Unimod:464 DiffAvg: 220.99 DiffFormula: (12)C 1 (13)C 6 H 5 N 1 O 3 S 2 DiffMono: 220.991214 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:464 4-sulfophenyl isothiocyanate (Heavy C13) SPITC:13C(6) OBSOLETE because Unimod entry 465 megerd with 199. Remap to MOD:00552 DiMethyl-CH2D. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD MOD:00881 N-reductive amination-D true MOD:00881 OBSOLETE because Unimod entry 465 megerd with 199. Remap to MOD:00552 DiMethyl-CH2D. PubMed:9252331 Unimod:465 DiffAvg: 32.06 DiffFormula: C 2 (2)H 4 DiffMono: 32.056407 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00552 Source: artifact TermSpec: none Unimod: Unimod:465 A protein modification that effectively converts an L-serine residue to S-(2-aminoethyl)cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Aminoethyl Cysteinyl (AECys) PSI-MOD AEC-MAEC aminoethylcysteine MOD:00882 From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. S-(2-aminoethyl)cysteine (Ser) MOD:00882 A protein modification that effectively converts an L-serine residue to S-(2-aminoethyl)cysteine. DeltaMass:171 PubMed:12923550 Unimod:472#S DiffAvg: 59.13 DiffFormula: C 2 H 5 N 1 O -1 S 1 DiffMono: 59.019356 Formula: C 5 H 10 N 2 O 1 S 1 MassAvg: 146.21 MassMono: 146.051384 Origin: S Source: artifact TermSpec: none Unimod: Unimod:472 Aminoethyl Cysteinyl (AECys) AEC-MAEC aminoethylcysteine A protein modification that effectively replaces a 1-carboxyl group (usually referred to as the alpha-carboxyl) with a carboxamido group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Amide formation (C terminus) ResN alpha-amidated residue ctermamide PSI-MOD Amidated Amidation MOD:00883 The normal biological process involves formation of an amide of an amino acid residue in a peptide sequence where it is followed by a glycine and two basic residues, either arginine or lysine, although in some taxa only one basic residue is required. The peptide is cleaved after the basic residues, glycine is oxidized to hydroxyglycine, which decomposes to release a carboxamide C-terminal [JSG]. C1-amidated residue MOD:00883 A protein modification that effectively replaces a 1-carboxyl group (usually referred to as the alpha-carboxyl) with a carboxamido group. DeltaMass:0 OMSSA:25 Unimod:2 DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: C-term Unimod: Unimod:2 Amide formation (C terminus) ResN alpha-amidated residue ctermamide Amidated Amidation A protein modification that effectively converts an L-cysteine residue to S-2-aminoethylcysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-thialysine L-cysteine aziridine adduct S-(2-aminoethyl)-L-cysteine PSI-MOD MOD:00884 This modified residue is a chemical isolog of L-lysine for trypsin hydolysis produced from L-cysteine by aziridine. S-aminoethylcysteine (Cys) MOD:00884 A protein modification that effectively converts an L-cysteine residue to S-2-aminoethylcysteine. PubMed:1175632 PubMed:18688235 DiffAvg: 43.07 DiffFormula: C 2 H 5 N 1 O 0 S 0 DiffMono: 43.042199 Formula: C 5 H 10 N 2 O 1 S 1 MassAvg: 146.21 MassMono: 146.051384 Origin: C Source: artifact TermSpec: none 4-thialysine L-cysteine aziridine adduct S-(2-aminoethyl)-L-cysteine A protein modification that crosslinks two residues by formation of an ester bond. PSI-MOD MOD:00885 ester crosslinked residues MOD:00885 A protein modification that crosslinks two residues by formation of an ester bond. PubMed:18688235 A protein modification that effectively converts an L-tryptophan residue to 6'-chloro-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0052 (2S)-2-amino-3-(6-chloro-1H-indol-3-yl)propanoic acid 6'-ClTrp 6'-chloro-L-tryptophan MOD_RES 6'-chlorotryptophan PSI-MOD MOD:00886 The Unimod:340 cross-reference to RESID:AA0180 is incorrect. RESID:AA0180 should be cross-referenced by Unimod:936 [JSG]. 6'-chloro-L-tryptophan MOD:00886 A protein modification that effectively converts an L-tryptophan residue to 6'-chloro-L-tryptophan. PubMed:9033387 RESID:AA0180 Unimod:936#W DiffAvg: 34.44 DiffFormula: C 0 Cl 1 H -1 N 0 O 0 DiffMono: 33.961028 Formula: C 11 Cl 1 H 9 N 2 O 1 MassAvg: 220.66 MassMono: 220.040341 Origin: W Source: natural TermSpec: none Unimod: Unimod:936 (2S)-2-amino-3-(6-chloro-1H-indol-3-yl)propanoic acid 6'-ClTrp 6'-chloro-L-tryptophan MOD_RES 6'-chlorotryptophan A protein modification that effectively converts an L-aspartic acid residue to a methylated aspartic acid, such as aspartic acid 4-methyl ester. PSI-MOD MOD:00887 methylated aspartic acid MOD:00887 A protein modification that effectively converts an L-aspartic acid residue to a methylated aspartic acid, such as aspartic acid 4-methyl ester. PubMed:18688235 A protein modification that effectively converts an L-proline to an L-prolinium (protonated L-proline). DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00888 protonated L-proline (L-prolinium) residue MOD:00888 A protein modification that effectively converts an L-proline to an L-prolinium (protonated L-proline). PubMed:18688235 DiffAvg: 1.01 DiffFormula: C 0 H 1 N 0 O 0 DiffMono: 1.007276 FormalCharge: 1+ Formula: C 5 H 9 N 1 O 1 MassAvg: 99.13 MassMono: 99.067865 Origin: P Source: natural TermSpec: N-term A protein modification that effectively converts an L-prolinium (charged L-proline) residue to N,N-dimethyl-L-proline. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:00889 N,N-dimethyl-L-proline (from L-prolinium) MOD:00889 A protein modification that effectively converts an L-prolinium (charged L-proline) residue to N,N-dimethyl-L-proline. Unimod:36#P DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.030752 FormalCharge: 1+ Formula: C 7 H 13 N 1 O 1 MassAvg: 127.19 MassMono: 127.099165 Origin: MOD:00888 Source: natural TermSpec: N-term Unimod: Unimod:36 A protein modification that effectively converts an L-histidine residue to a phosphorylated L-histidine, such as pros-phosphohistidine, or tele-phosphohistidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0252 NPhosHis mod192 phosphohistidine PSI-MOD Phospho MOD:00890 phosphorylated L-histidine MOD:00890 A protein modification that effectively converts an L-histidine residue to a phosphorylated L-histidine, such as pros-phosphohistidine, or tele-phosphohistidine. OMSSA:192 Unimod:21#H DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 6 H 8 N 3 O 4 P 1 MassAvg: 217.12 MassMono: 217.025242 Origin: H Source: natural TermSpec: none Unimod: Unimod:21 NPhosHis mod192 phosphohistidine Phospho A protein modification that effectively converts a source amino acid residue to D-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (R)-2-amino-3-hydroxypropanoic acid D-Ser D-serine PSI-MOD MOD:00891 D-serine MOD:00891 A protein modification that effectively converts a source amino acid residue to D-serine. ChEBI:29998 PubMed:6893271 PubMed:7973665 RESID:AA0195 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 3 H 5 N 1 O 2 MassAvg: 87.08 MassMono: 87.032028 Origin: X Source: natural TermSpec: none (R)-2-amino-3-hydroxypropanoic acid D-Ser D-serine A protein modification that effectively converts an L-cysteine residue to D-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0309 (R)-2-amino-3-hydroxypropanoic acid D-serine MOD_RES D-serine (Cys) PSI-MOD MOD:00892 D-serine (Cys) MOD:00892 A protein modification that effectively converts an L-cysteine residue to D-serine. PubMed:18025465 PubMed:6893271 RESID:AA0195#CYS DiffAvg: -16.06 DiffFormula: C 0 H 0 N 0 O 1 S -1 DiffMono: -15.977156 Formula: C 3 H 5 N 1 O 2 MassAvg: 87.08 MassMono: 87.032028 Origin: C Source: natural TermSpec: none (R)-2-amino-3-hydroxypropanoic acid D-serine MOD_RES D-serine (Cys) Natural or modified residues with a mass of 128.0-128.1 Da. PSI-MOD MOD:00893 residues isobaric at 128.0-128.1 MOD:00893 Natural or modified residues with a mass of 128.0-128.1 Da. PubMed:18688235 Natural or modified resiues with a mass of 128.058578 Da. PSI-MOD MOD:00894 residues isobaric at 128.058578 Da MOD:00894 Natural or modified resiues with a mass of 128.058578 Da. PubMed:18688235 A protein modification that effectively results from forming an adduct with a compound containing a flavin adenine dinucleotide (FAD) group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: FADRes PSI-MOD MOD:00895 FAD modified residue MOD:00895 A protein modification that effectively results from forming an adduct with a compound containing a flavin adenine dinucleotide (FAD) group. PubMed:18688235 DiffAvg: 783.54 DiffFormula: C 27 H 31 N 9 O 15 P 2 DiffMono: 783.141485 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none FADRes A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: FMNRes PSI-MOD MOD:00896 FMN modified residue MOD:00896 A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none FMNRes A protein modification that effectively converts an L-cysteine residue to N-acetyl-S-archeol-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00897 N-acetyl-S-archeol-cysteine MOD:00897 A protein modification that effectively converts an L-cysteine residue to N-acetyl-S-archeol-L-cysteine. RESID:AA0043#var RESID:AA0223#var DiffAvg: 677.20 DiffFormula: C 45 H 88 N 0 O 3 S 0 DiffMono: 676.673347 Formula: C 48 H 93 N 1 O 4 S 1 MassAvg: 780.34 MassMono: 779.682531 Origin: C Source: natural TermSpec: N-term A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Diacylglycerol diacylglycerol MOD:00898 Incidental to RESID:AA0060. S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine MOD:00898 A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine. PubMed:10896212 PubMed:4575979 PubMed:9056182 RESID:AA0107#var Unimod:377 DiffAvg: 576.95 DiffFormula: C 37 H 68 N 0 O 4 S 0 DiffMono: 576.511761 Formula: C 40 H 73 N 1 O 5 S 1 MassAvg: 680.09 MassMono: 679.520945 Origin: C Source: natural TermSpec: none Unimod: Unimod:377 Diacylglycerol diacylglycerol A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-diacylglycerol-L-cysteine. Origin: Source: TermSpec: PSI-MOD MOD:00899 N-palmitoyl-S-diacylglycerol-L-cysteine MOD:00899 A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-diacylglycerol-L-cysteine. RESID:AA0069#var RESID:AA0107#var Origin: C Source: natural TermSpec: N-term A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (R)-2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid 2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid PSI-MOD MOD:00900 N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine MOD:00900 A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine. PubMed:18688235 DiffAvg: 815.36 DiffFormula: C 53 H 98 N 0 O 5 S 0 DiffMono: 814.741426 Formula: C 56 H 103 N 1 O 6 S 1 MassAvg: 918.50 MassMono: 917.750611 Origin: C Source: natural TermSpec: N-term (R)-2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid 2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid A protein modification that modifies an L-alanine. Origin: ModAla PSI-MOD MOD:00901 modified L-alanine residue MOD:00901 A protein modification that modifies an L-alanine. PubMed:18688235 Origin: A ModAla A protein modification that modifies an L-arginine residue. Origin: ModArg PSI-MOD MOD:00902 modified L-arginine residue MOD:00902 A protein modification that modifies an L-arginine residue. PubMed:18688235 Origin: R ModArg A protein modification that modifies an L-asparagine residue. Origin: ModAsn PSI-MOD MOD:00903 modified L-asparagine residue MOD:00903 A protein modification that modifies an L-asparagine residue. PubMed:18688235 Origin: N ModAsn A protein modification that modifies an L-aspartic acid residue. Origin: ModAsp PSI-MOD MOD:00904 modified L-aspartic acid residue MOD:00904 A protein modification that modifies an L-aspartic acid residue. PubMed:18688235 Origin: D ModAsp A protein modification that modifies an L-cysteine residue. Origin: ModCys PSI-MOD MOD:00905 modified L-cysteine residue MOD:00905 A protein modification that modifies an L-cysteine residue. PubMed:18688235 Origin: C ModCys A protein modification that modifies an L-glutamic acid residue. Origin: ModGlu PSI-MOD MOD:00906 modified L-glutamic acid residue MOD:00906 A protein modification that modifies an L-glutamic acid residue. PubMed:18688235 Origin: E ModGlu A protein modification that modifies an L-glutamine residue. Origin: ModGln PSI-MOD MOD:00907 modified L-glutamine residue MOD:00907 A protein modification that modifies an L-glutamine residue. PubMed:18688235 Origin: Q ModGln A protein modification that modifies a glycine residue. Origin: ModGly PSI-MOD MOD:00908 modified glycine residue MOD:00908 A protein modification that modifies a glycine residue. PubMed:18688235 Origin: G ModGly A protein modification that modifies an L-histidine residue. Origin: ModHis PSI-MOD MOD:00909 modified L-histidine residue MOD:00909 A protein modification that modifies an L-histidine residue. PubMed:18688235 Origin: H ModHis A protein modification that modifies an L-isoleucine residue. Origin: ModIle PSI-MOD MOD:00910 modified L-isoleucine residue MOD:00910 A protein modification that modifies an L-isoleucine residue. PubMed:18688235 Origin: I ModIle A protein modification that modifies an L-leucine residue. Origin: ModLeu PSI-MOD MOD:00911 modified L-leucine residue MOD:00911 A protein modification that modifies an L-leucine residue. PubMed:18688235 Origin: L ModLeu A protein modification that modifies an L-lysine residue. Origin: ModLys PSI-MOD MOD:00912 modified L-lysine residue MOD:00912 A protein modification that modifies an L-lysine residue. PubMed:18688235 Origin: K ModLys A protein modification that modifies an L-methionine residue. Origin: ModMet PSI-MOD MOD:00913 modified L-methionine residue MOD:00913 A protein modification that modifies an L-methionine residue. PubMed:18688235 Origin: M ModMet A protein modification that modifies an L-phenylalanine residue. Origin: ModPhe PSI-MOD MOD:00914 modified L-phenylalanine residue MOD:00914 A protein modification that modifies an L-phenylalanine residue. PubMed:18688235 Origin: F ModPhe A protein modification that modifies an L-proline residue. Origin: ModPro PSI-MOD MOD:00915 modified L-proline residue MOD:00915 A protein modification that modifies an L-proline residue. PubMed:18688235 Origin: P ModPro A protein modification that modifies an L-serine residue. Origin: ModSer PSI-MOD MOD:00916 modified L-serine residue MOD:00916 A protein modification that modifies an L-serine residue. PubMed:18688235 Origin: S ModSer A protein modification that modifies an L-threonine residue. Origin: ModThr PSI-MOD MOD:00917 modified L-threonine residue MOD:00917 A protein modification that modifies an L-threonine residue. PubMed:18688235 Origin: T ModThr A protein modification that modifies an L-tryptophan residue. Origin: ModTrp PSI-MOD MOD:00918 modified L-tryptophan residue MOD:00918 A protein modification that modifies an L-tryptophan residue. PubMed:18688235 Origin: W ModTrp A protein modification that modifies an L-tyrosine residue. Origin: ModTyr PSI-MOD MOD:00919 modified L-tyrosine residue MOD:00919 A protein modification that modifies an L-tyrosine residue. PubMed:18688235 Origin: Y ModTyr A protein modification that modifies an L-valine residue. Origin: ModVal PSI-MOD MOD:00920 modified L-valine residue MOD:00920 A protein modification that modifies an L-valine residue. PubMed:18688235 Origin: V ModVal New uncategorized Unimod. OBSOLETE because organizational use is no longer required. PSI-MOD MOD:00921 new uncategorized Unimod entries true MOD:00921 New uncategorized Unimod. OBSOLETE because organizational use is no longer required. PubMed:18688235 modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cy3 CyDye DIGE Fluor saturation dye CyDye-Cy3 MOD:00922 Cy3 CyDye DIGE Fluor saturation dye MOD:00922 modification from Unimod Chemical derivative Unimod:494 DiffAvg: 672.84 DiffFormula: C 37 H 44 N 4 O 6 S 1 DiffMono: 672.298156 Formula: C 40 H 49 N 5 O 7 S 2 MassAvg: 775.98 MassMono: 775.307341 Origin: C Source: artifact TermSpec: none Unimod: Unimod:494 Cy3 CyDye DIGE Fluor saturation dye CyDye-Cy3 modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cy5 CyDye DIGE Fluor saturation dye CyDye-Cy5 MOD:00923 Cy5 CyDye DIGE Fluor saturation dye MOD:00923 modification from Unimod Chemical derivative Unimod:495 DiffAvg: 684.85 DiffFormula: C 38 H 44 N 4 O 6 S 1 DiffMono: 684.298156 Formula: C 41 H 49 N 5 O 7 S 2 MassAvg: 787.99 MassMono: 787.307341 Origin: C Source: artifact TermSpec: none Unimod: Unimod:495 Cy5 CyDye DIGE Fluor saturation dye CyDye-Cy5 A protein modification that effectively crosslinks an L-lysine residue and an L-threonine residue by an isopeptide bond to form N6-(L-threonyl)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0326 (2S)-2-amino-6-([(2S,3R)-2-amino-3-hydroxybutanoyl]amino)hexanoic acid N6-(L-threonyl)-L-lysine N6-threonyl-lysine PSI-MOD MOD:00924 Cross-link 2. N6-(L-threonyl)-L-lysine MOD:00924 A protein modification that effectively crosslinks an L-lysine residue and an L-threonine residue by an isopeptide bond to form N6-(L-threonyl)-L-lysine. PubMed:18063774 RESID:AA0440 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 10 H 18 N 3 O 3 MassAvg: 228.27 MassMono: 228.134816 Origin: K, T Source: natural TermSpec: C-term (2S)-2-amino-6-([(2S,3R)-2-amino-3-hydroxybutanoyl]amino)hexanoic acid N6-(L-threonyl)-L-lysine N6-threonyl-lysine A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a heptose sugar group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hep Heptose MOD:00925 From Unimod with no citation [JSG]. heptosylated residue MOD:00925 A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a heptose sugar group through a glycosidic bond. Unimod:490 DiffAvg: 192.17 DiffFormula: C 7 H 12 O 6 DiffMono: 192.063388 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:490 Hep Heptose Modification from Unimod Non-standard residue. OBSOLETE because not an amino acid modification. From Unimod not an approved entry. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD BADGE Bisphenol A diglycidyl ether derivative MOD:00926 Bisphenol A diglycidyl ether derivative true MOD:00926 Modification from Unimod Non-standard residue. OBSOLETE because not an amino acid modification. From Unimod not an approved entry. PubMed:11225353 Unimod:493 DiffAvg: 340.42 DiffFormula: C 21 H 24 O 4 DiffMono: 340.167459 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:493 BADGE Bisphenol A diglycidyl ether derivative A protein modification that effectively replaces two hydrogen atoms of a residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD DiMethyl-C13HD2 Dimethyl:2H(4)13C(2) MOD:00927 2x(13)C,4x(2)H labeled dimethylated residue MOD:00927 A protein modification that effectively replaces two hydrogen atoms of a residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated residue. PubMed:16335955 PubMed:3802193 Unimod:510 DiffAvg: 34.06 DiffFormula: (13)C 2 (2)H 4 DiffMono: 34.063117 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:510 DiMethyl-C13HD2 Dimethyl:2H(4)13C(2) modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD C8-QAT [3-(2,5)-Dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium MOD:00928 Should have children for K and X-N-term [JSG]. [3-(2,5)-dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium MOD:00928 modification from Unimod Chemical derivative PubMed:16771548 Unimod:513 DiffAvg: 227.39 DiffFormula: C 14 H 29 N 1 O 1 DiffMono: 227.224915 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:513 C8-QAT [3-(2,5)-Dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium A modification produced in a non-enzymatic reaction between a lactose carbonyl group and an L-lysine to form a Schiff-base or an Amadori ketosamine lysine adduct. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0511 CARBOHYD N-linked (Lac) (glycation) lysine PSI-MOD Hex(2) Lactosylation MOD:00929 The term lactosylation used with this meaning is a misnomer [JSG]. lactose glycated lysine MOD:00929 A modification produced in a non-enzymatic reaction between a lactose carbonyl group and an L-lysine to form a Schiff-base or an Amadori ketosamine lysine adduct. PubMed:9606156 Unimod:512 DiffAvg: 342.30 DiffFormula: C 12 H 22 O 11 DiffMono: 342.116212 Formula: C 18 H 34 N 2 O 12 MassAvg: 470.47 MassMono: 470.211175 Origin: K Source: natural TermSpec: none Unimod: Unimod:512 CARBOHYD N-linked (Lac) (glycation) lysine Hex(2) Lactosylation tyrosine adduct with substrate analog inhibitor 1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2'-thiazoline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:00930 propyl-NAG tyrosine adduct MOD:00930 tyrosine adduct with substrate analog inhibitor 1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2'-thiazoline. PubMed:15795231 Unimod:514 DiffAvg: 232.27 DiffFormula: C 9 H 14 N 1 O 4 S 1 DiffMono: 232.064354 Formula: C 18 H 23 N 2 O 6 S 1 MassAvg: 395.45 MassMono: 395.127682 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:514 modification from Unimod Other - BHTOH is formed upon metabolism of BHT with P450 enzymes. The BHTOH is further metabolized to its quinone methide (electrophile) which reacts with -SH and -NH2 groups DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD BHTOH Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K MOD:00931 Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K MOD:00931 modification from Unimod Other - BHTOH is formed upon metabolism of BHT with P450 enzymes. The BHTOH is further metabolized to its quinone methide (electrophile) which reacts with -SH and -NH2 groups PubMed:11085420 Unimod:498 DiffAvg: 234.34 DiffFormula: C 15 H 22 O 2 DiffMono: 234.161980 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:498 BHTOH Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Heavy IDBEST tag for quantitation IGBP:13C(2) MOD:00932 IDBEST tag for quantitation MOD:00932 modification from Unimod Isotopic label PubMed:11821862 Unimod:499 DiffAvg: 298.02 DiffFormula: Br 1 (12)C 10 (13)C 2 H 13 N 2 O 2 DiffMono: 298.022749 Formula: Br 1 (12)C 13 (13)C 2 H 18 N 3 O 3 S 1 MassAvg: 401.03 MassMono: 401.031934 Origin: C Source: artifact TermSpec: none Unimod: Unimod:499 Heavy IDBEST tag for quantitation IGBP:13C(2) modification from Unimod Chemical derivative - 5-hydro-5-methylimidazol-4-one, arginine methylglyoxal arginine adduct (+54 amu) DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:H(2)C(3)O(1) MDA adduct +54 MOD:00933 Ref. Uchida K, Sakai K, Itakura K, Osawa T, Toyokuni S. 1977. Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins. Arch Biochem Biophys. 346(1):45-52. methylglyoxal arginine adduct (+54 amu) MOD:00933 modification from Unimod Chemical derivative - 5-hydro-5-methylimidazol-4-one, arginine methylglyoxal arginine adduct (+54 amu) Unimod:319#R DiffAvg: 54.05 DiffFormula: C 3 H 2 O 1 DiffMono: 54.010565 Formula: C 9 H 14 N 4 O 2 MassAvg: 210.24 MassMono: 210.111676 Origin: R Source: artifact TermSpec: none Unimod: Unimod:319 Delta:H(2)C(3)O(1) MDA adduct +54 modification from Unimod Post-translational DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD LG-Hlactam-R Levuglandinyl - arginine hydroxylactam adduct MOD:00934 Levuglandinyl - arginine hydroxylactam adduct MOD:00934 modification from Unimod Post-translational Unimod:506 DiffAvg: 306.40 DiffFormula: C 19 H 26 N -2 O 5 DiffMono: 306.171876 Formula: C 25 H 38 N 2 O 6 MassAvg: 462.59 MassMono: 462.272987 Origin: R Source: natural TermSpec: none Unimod: Unimod:506 LG-Hlactam-R Levuglandinyl - arginine hydroxylactam adduct Oxidation of methionine to methionine sulfoxide with neutral loss of CH3SOH. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00935 Originally created from Unimod:507 that was later deleted. methionine oxidation with neutral loss of 64 Da MOD:00935 Oxidation of methionine to methionine sulfoxide with neutral loss of CH3SOH. PubMed:18688235 PubMed:9004526 DiffAvg: -64.10 DiffFormula: C -1 H -4 N 0 O -1 S -1 DiffMono: -63.998286 Formula: C 4 H 5 N 1 O 1 S 0 MassAvg: 83.09 MassMono: 83.037114 Origin: M Source: artifact TermSpec: none modification from Unimod Post-translational DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD LG-Hlactam-K Levuglandinyl - lysine hydroxylactam adduct MOD:00936 Levuglandinyl - hydroxylactam adduct, K and N-term MOD:00936 modification from Unimod Post-translational Unimod:504 DiffAvg: 348.44 DiffFormula: C 20 H 28 O 5 DiffMono: 348.193674 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:504 LG-Hlactam-K Levuglandinyl - lysine hydroxylactam adduct modification from Unimod Post-translational DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD LG-lactam-R Levuglandinyl - arginine lactam adduct MOD:00937 Levuglandinyl - arginine lactam adduct MOD:00937 modification from Unimod Post-translational Unimod:505 DiffAvg: 290.40 DiffFormula: C 19 H 26 N -2 O 4 DiffMono: 290.176961 Formula: C 25 H 38 N 2 O 5 MassAvg: 446.59 MassMono: 446.278072 Origin: R Source: artifact TermSpec: none Unimod: Unimod:505 LG-lactam-R Levuglandinyl - arginine lactam adduct modification from Unimod Post-translational DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD LG-lactam-K Levuglandinyl - lysine lactam adduct MOD:00938 Levuglandinyl - lactam adduct, K and N-term MOD:00938 modification from Unimod Post-translational PubMed:12590383 Unimod:503 DiffAvg: 332.44 DiffFormula: C 20 H 28 O 4 DiffMono: 332.198759 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:503 LG-lactam-K Levuglandinyl - lysine lactam adduct modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Nmethylmaleimide+water Nmethylmaleimidehydrolysis MOD:00939 hydrolyzed N-methylmaleimide cysteine adduct MOD:00939 modification from Unimod Chemical derivative Unimod:500 DiffAvg: 129.12 DiffFormula: C 5 H 7 N 1 O 3 DiffMono: 129.042593 Formula: C 8 H 12 N 2 O 4 S 1 MassAvg: 232.25 MassMono: 232.051778 Origin: C Source: artifact TermSpec: none Unimod: Unimod:500 Nmethylmaleimide+water Nmethylmaleimidehydrolysis A protein modification produced by formation of an adduct with 3-methyl-2-pyridyl isocyanate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 3-methyl-2-pyridyl isocyanate PyMIC MOD:00940 3-methyl-2-pyridyl isocyanate derivatized residue MOD:00940 A protein modification produced by formation of an adduct with 3-methyl-2-pyridyl isocyanate. PubMed:11078590 Unimod:501 DiffAvg: 134.14 DiffFormula: C 7 H 6 N 2 O 1 DiffMono: 134.048013 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:501 3-methyl-2-pyridyl isocyanate PyMIC modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD DHP Dehydropyrrolizidine alkaloid (dehydroretronecine) on cysteines MOD:00941 dehydropyrrolizidine alkaloid (dehydroretronecine) derivatized cysteine MOD:00941 modification from Unimod Chemical derivative PubMed:12175151 Unimod:488 DiffAvg: 118.16 DiffFormula: C 8 H 8 N 1 DiffMono: 118.065674 Formula: C 11 H 13 N 2 S 1 MassAvg: 205.30 MassMono: 205.079944 Origin: C Source: artifact TermSpec: none Unimod: Unimod:488 DHP Dehydropyrrolizidine alkaloid (dehydroretronecine) on cysteines A protein modification that effectively substitutes four (1)H protium atoms with four (2)H deuterium atoms to produce (4,4,5,5-(2)H4)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 4,4,5,5-tetradeuterolysine lys-2H4 PSI-MOD 4,4,5,5-D4 Lysine Label:2H(4) MOD:00942 For SILAC experiments. (4,4,5,5-(2)H4)-L-lysine MOD:00942 A protein modification that effectively substitutes four (1)H protium atoms with four (2)H deuterium atoms to produce (4,4,5,5-(2)H4)-L-lysine. OMSSA:180 Unimod:481 DiffAvg: 4.03 DiffFormula: (1)H -4 (2)H 4 DiffMono: 4.025107 Formula: C 6 (1)H 8 (2)H 4 N 2 O 1 MassAvg: 132.12 MassMono: 132.120070 Origin: K Source: artifact TermSpec: none Unimod: Unimod:481 4,4,5,5-tetradeuterolysine lys-2H4 4,4,5,5-D4 Lysine Label:2H(4) modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 4-trimethyllammoniumbutyryl- TMAB MOD:00943 4-trimethylammoniumbutanoyl derivatized residue MOD:00943 modification from Unimod Isotopic label PubMed:12643539 Unimod:476 DiffAvg: 128.19 DiffFormula: C 7 H 14 N 1 O 1 DiffMono: 128.107539 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:476 4-trimethyllammoniumbutyryl- TMAB modification from Unimod Isotopic label DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD TMAB:2H(9) d9-4-trimethyllammoniumbutyryl- MOD:00944 d9-4-trimethylammoniumbutanoyl derivatized residue MOD:00944 modification from Unimod Isotopic label Unimod:477 DiffAvg: 137.16 DiffFormula: C 7 (1)H 5 (2)H 9 N 1 O 1 DiffMono: 137.164030 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:477 TMAB:2H(9) d9-4-trimethyllammoniumbutyryl- OBSOLETE because redundant and identical to MOD:00626. Remap to MOD:00626. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00945 fluorescein-5-thiosemicarbazide adduct true MOD:00945 OBSOLETE because redundant and identical to MOD:00626. Remap to MOD:00626. PubMed:18688235 DiffAvg: 421.43 DiffFormula: C 21 H 15 N 3 O 5 S 1 DiffMono: 421.073242 Formula: none MassAvg: none MassMono: none Origin: S Remap: MOD:00626 Source: artifact TermSpec: none A protein modification that crosslinks two residues with a covalent bond and the loss of ammonia. PSI-MOD MOD:00946 crosslinked residues with loss of ammonia MOD:00946 A protein modification that crosslinks two residues with a covalent bond and the loss of ammonia. PubMed:18688235 Entries from DeltaMass see http://www.abrf.org/index.cfm/dm.home?AvgMass=all. PSI-MOD MOD:00947 DeltaMass MOD:00947 Entries from DeltaMass see http://www.abrf.org/index.cfm/dm.home?AvgMass=all. PubMed:18688235 OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00948 From DeltaMass: Average Mass: -79 5'-dephospho true MOD:00948 OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none OBSOLETE because redundant and identical to MOD:01933. Remap to MOD:01933. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00949 From DeltaMass: Average Mass: -58 desmosine true MOD:00949 OBSOLETE because redundant and identical to MOD:01933. Remap to MOD:01933. DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: K Remap: MOD:01933 Source: none TermSpec: none OBSOLETE because this modification has not been seen/reported on since this original publication in 1994 and carboxymethylation of proteins is common enough for this mass shift to have been seen in the intervening 25+ years. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00950 From DeltaMass: Average Mass: -48 Average Mass Change:-48 References:Anal. Biochem. Vol 216 No.1 p141 decomposed carboxymethylated methionine true MOD:00950 OBSOLETE because this modification has not been seen/reported on since this original publication in 1994 and carboxymethylation of proteins is common enough for this mass shift to have been seen in the intervening 25+ years. modification from DeltaMass DeltaMass:3 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: M Source: none TermSpec: none Covalent modification of a peptide or protein L-glutamic acid residue to gamma-carboxyglutamic acid with secondary loss of a neutral carbon dioxide molecular fragment. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: d4CbxGlu PSI-MOD MOD:00951 From DeltaMass: Average Mass: -44 Formula:CO2 Average Mass Change:-44 References:Nakamura T, Yu Z, Fainzilber M, Burlingame AL. Protein Sci (1996) 5, 524-530 Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile. Notes: The elimination of CO2 will regenerate glutamate as if there was no modification. However, peaks appearing with an interval of 44 is quite characteristic. It would be noteworthy to remind that loss of 44 from a gamma-carboxyglutamate-containing peptide may be observed not only as a result of spontaneous decarboxylation but also as an artifact under some ionization conditions such as negative ion mode MALDI. L-gamma-carboxyglutamic acid with neutral loss of carbon dioxide MOD:00951 Covalent modification of a peptide or protein L-glutamic acid residue to gamma-carboxyglutamic acid with secondary loss of a neutral carbon dioxide molecular fragment. DeltaMass:58 DiffAvg: -44.01 DiffFormula: C -1 H 0 N 0 O -2 DiffMono: -43.989829 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: E Source: artifact TermSpec: none d4CbxGlu A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the loss of a water molecule. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0312 (2-aminosuccinimidyl)acetic acid (3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid CROSSLNK (2-aminosuccinimidyl)acetic acid (Asp-Gly) N-(2-aminosuccinyl)glycine [(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid anhydroaspartyl glycine aspartimide glycine PSI-MOD MOD:00952 Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue with the alpha-amido of the following residue. (2-aminosuccinimidyl)acetic acid (Asp) MOD:00952 A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the loss of a water molecule. PubMed:10801322 RESID:AA0441#ASP DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 6 H 6 N 2 O 3 MassAvg: 154.13 MassMono: 154.037842 Origin: D, G Source: hypothetical TermSpec: none (2-aminosuccinimidyl)acetic acid (3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid CROSSLNK (2-aminosuccinimidyl)acetic acid (Asp-Gly) N-(2-aminosuccinyl)glycine [(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid anhydroaspartyl glycine aspartimide glycine A protein modification that effectively crosslinks an L-glutamic acid residue and an L-serine residue by an ester bond and releasing water to form O-(L-isoglutamyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid CROSSLNK isoglutamyl serine ester (Ser-Glu) O(beta)-(gamma-glutamyl)serine O-(L-isoglutamyl)-L-serine O-gamma-Glutamyl- (Crosslink to Serine) O3-(isoglutamyl)-serine PSI-MOD MOD:00953 Cross-link 2; From DeltaMass: with no citation. O-(L-isoglutamyl)-L-serine (Glu-Ser) MOD:00953 A protein modification that effectively crosslinks an L-glutamic acid residue and an L-serine residue by an ester bond and releasing water to form O-(L-isoglutamyl)-L-serine. DeltaMass:0 PubMed:19035375 RESID:AA0597#ESX DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 8 H 10 N 2 O 4 MassAvg: 198.18 MassMono: 198.064057 Origin: E, S Source: artifact TermSpec: none (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid CROSSLNK isoglutamyl serine ester (Ser-Glu) O(beta)-(gamma-glutamyl)serine O-(L-isoglutamyl)-L-serine O-gamma-Glutamyl- (Crosslink to Serine) O3-(isoglutamyl)-serine A protein modification that crosslinks two residues with a covalent bond and the loss of water. PSI-MOD MOD:00954 crosslinked residues with loss of water MOD:00954 A protein modification that crosslinks two residues with a covalent bond and the loss of water. PubMed:18688235 A protein modification that effectively crosslinks an L-serine residue and an L-histidine residue to release water and form tele- or pros-(2-amino-2-carboxyethyl)histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: beta-alaninohistidine PSI-MOD MOD:00955 Cross-link 2; From DeltaMass with no citation or formula: Average Mass: -18. The DeltaMass description "Serine crosslinked to theta or pi carbon of Histidine" is incorrect. The histidine ring nitrogens (not carbons) are designated tele or N-tau (not theta), and pros or N-pi [JSG]. alaninohistidine (serine crosslinked to tele or pros nitrogen of histidine) MOD:00955 A protein modification that effectively crosslinks an L-serine residue and an L-histidine residue to release water and form tele- or pros-(2-amino-2-carboxyethyl)histidine. DeltaMass:0 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 9 H 10 N 4 O 2 MassAvg: 206.20 MassMono: 206.080376 Origin: H, S Source: artifact TermSpec: none beta-alaninohistidine modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00956 From DeltaMass: Average Mass: -18 Average Mass Change:-18 Notes: It has the same mass as leucine or isoleucine and can be charged on the methionyl t-RNA. This often happens in minimal media-prepared fermentations that are not supplemented with enough free methionine. It gives a mass change of -18 and can often be confused with dehydration. misincorporation of norleucine for methionine MOD:00956 modification from DeltaMass DeltaMass:10 DiffAvg: -18.03 DiffFormula: C 1 H 2 N 0 O 0 S -1 DiffMono: -17.956421 Formula: C 6 H 11 N 1 O 1 MassAvg: 113.16 MassMono: 113.084064 Origin: M Source: none TermSpec: none Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral carbon dioxide molecular fragment. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: dCO2ModRes PSI-MOD MOD:00957 modified residue with neutral loss of carbon dioxide MOD:00957 Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral carbon dioxide molecular fragment. PubMed:18688235 DiffAvg: -44.01 DiffFormula: C -1 H 0 N 0 O -2 DiffMono: -43.989829 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none dCO2ModRes modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00958 Cross-link 2; From DeltaMass: Average Mass: -5 crosslink between Arg and His sidechains MOD:00958 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: H, R Source: none TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00959 Cross-link 4; From DeltaMass: Average Mass: -4 3,3',5,5'-TerTyr (Crosslink) MOD:00959 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: Y, Y, Y, Y Source: none TermSpec: none A protein modification that effectively replaces a carboxylic acid group with a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00960 decarboxylated residue MOD:00960 A protein modification that effectively replaces a carboxylic acid group with a hydrogen atom. PubMed:18688235 DiffAvg: -44.01 DiffFormula: C -1 H 0 N 0 O -2 DiffMono: -43.989829 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none A protein modification that effectively reduces the disulfide bond of cystine to form two cysteine residues. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00961 Cross-link 2; this modification destroys the cross-link. From DeltaMass: Treatment of cystine (cys-cys) by reducing agents such as dithiothreitol (DTT) or triscarboxyethylphosphine (TCEP) results in cleavage of the disulphide bond and reduction of the sulphur atom of each molecule to create cysteine. reduction of disulfide crosslink in cystine to two cysteines MOD:00961 A protein modification that effectively reduces the disulfide bond of cystine to form two cysteine residues. DeltaMass:333 DiffAvg: 2.02 DiffFormula: C 0 H 2 N 0 O 0 S 0 DiffMono: 2.015650 Formula: C 6 H 10 N 2 O 2 S 2 MassAvg: 206.28 MassMono: 206.018370 Origin: MOD:00034 Source: none TermSpec: none A protein modification that by reducing the indole ring system of tryptophan to indoline effectively converts an L-tryptophan residue to 2',3'-dihydrotryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00962 From DeltaMass: References:1. Pearson,D.A., Blanchette,M., Baker,M.L. and Guindon,C.A. (1989) Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking ofprotecting groups in peptide synthesis. Tetrahedron Lett., 30(21), 2739-2742 Notes: Reduction of indole double bond of Trp which occurs when triethylsilane (TES) is used as a scavenger and Trp is incorporated without protection of indole nitrogen [1]. This side reaction is likely to be accompanied by oxidation of indoline ring with formation of intensively colored peptide by-products. Triisopropylsilane (TIPS) does not give this side reaction. See structure at http://www.abrf.org/images/misc/dmass2.gif. [However, the pictured indoline structure is incorrect - JSG]. 2',3'-dihydrotryptophan MOD:00962 A protein modification that by reducing the indole ring system of tryptophan to indoline effectively converts an L-tryptophan residue to 2',3'-dihydrotryptophan. DeltaMass:343 URL:http://dx.doi.org/10.1016/S0040-4039(00)99113-5 DiffAvg: 2.02 DiffFormula: C 0 H 2 N 0 O 0 S 0 DiffMono: 2.015650 Formula: C 11 H 12 N 2 O 1 MassAvg: 188.23 MassMono: 188.094963 Origin: W Source: artifact TermSpec: none Modification from DeltaMass. OBSOLETE because redundant and identical to MOD:00462. Remap to MOD:00462. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00963 From DeltaMass: Average Mass: 4 Monoisotopic Mass Change:3.995 Average Mass Change:3.989 References:Ruoppolo M, Amoresano A, Pucci P, Pascarella S, Polticelli F, Trovato M,Menegatti E, Ascenzi P.Characterization of five new low-molecular-mass trypsin inhibitors fromwhite mustard (Sinapis alba L.) seed.Eur J Biochem. 2000 267:6486-92. Notes: See structure at http://www.abrf.org/images/misc/dmass32.jpg. Oxidation of Trp to kynurenine true MOD:00963 Modification from DeltaMass. OBSOLETE because redundant and identical to MOD:00462. Remap to MOD:00462. DeltaMass:357 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: W Remap: MOD:00462 Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N6-(methylidene)-lysine PSI-MOD MOD:00964 From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Mathews, W. Rodney; Runge, Thomas A.; Haroldsen, Peter E.; Gaskell, Simon J. (1989) Characterization of impurities in a synthetic renin substrate peptide by fast-atom bombardment mass spectrometry and hybrid tandem mass spectrometry. Rapid Commun. Mass Spectrom. 3(9), 314-19 Notes: Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side products, including a component 12 Da higher in mass. Low-energy collisionally activated ***decompn*** analyses were performed using a hybrid tandem instrument and demonstrated that the heavier side product had two components, in which the structural modification was either at the N- or the C-terminus. Addnl. analyses of the N-acetyl deriv. indicated that for each component the structural modification blocked a site of N-acetylation. It is suggested that the formation of these side products is attributable to the generation of formaldehyde, during removal of the histidine protecting group (benzyloxymethyl), which reacts with the N-terminus of the peptide to give an imidazolidinone structure or with the D- ***lysine***.epsilon.-amine group to yield an ***imine*** . While the precise genesis of the side-products remains speculative, it is clear that the combined strategy of derivatization and tandem mass spectrometry has allowed structural conclusions concerning individual components of an isobaric mixt. lysine epsilon amino to imine + 12 amu MOD:00964 modification from DeltaMass DeltaMass:34 DiffAvg: 12.01 DiffFormula: C 1 H 0 N 0 O 0 DiffMono: 12.000000 Formula: C 7 H 12 N 2 O 1 MassAvg: 140.19 MassMono: 140.094963 Origin: K Source: artifact TermSpec: none N6-(methylidene)-lysine A protein modification that effectively converts an N-terminal L-cysteine residue by a formadehyde adduct to 4-thiazolidinecarboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: thioproline PSI-MOD MOD:00965 From DeltaMass: References: Mitchell, M.A., Runge, T.A., Mathews, W.R., Ichhpurani, A.K., Harn, N.K., Dobrowolski, P.J. and Eckenrrrode, F.M. Problems associated with use of the benzylozymethyl protecting group for histidines. Formaldehyde adducts formed during cleavage by hydrogen fluoride. Int. J. Pept. Protein Res. 1990, 36(4), 350-355. Gesquiere, J.-C., Diesis, E. and Tartar, A. Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deprotection of peptides containing pi-N-Bom protected histidine. J. Chem. Soc. Chem. Commun. 1990, (20), 1402-1403. Kumagaye, K.Y., Inui, T., Nakajima, K., Kimura,T. and Sakakibara, S. Suppression of a side reaction associated with Nim-benzyloxymethyl group during synthesis of peptides containing cysteinyl residue at the N-terminus. Pept. Res. 1991, 4(2), 84-87. Colombo, R., Colombo, F. and Jones, J.H. Acid-labile histidine side-chain protection. The N(pi)-t-butoxymethyl group. J. Chem. Soc. Chem. Commun. 1984, (5), 292-293. Notes: Conversion of N-term Cys to thiazolidine during HF deprotection of His(Bom)-containing peptides [1-3]. See structure at http://www.abrf.org/images/misc/dmass12b.gif; modification in red. This modification cannot be excluded during final deprotection/cleavage in Fmoc-chemistry in cases when His(Bum) was employed [4]. For formation of free imino acid see PubMed:1527501. 4-thiazolidinecarboxylic acid MOD:00965 A protein modification that effectively converts an N-terminal L-cysteine residue by a formadehyde adduct to 4-thiazolidinecarboxylic acid. DeltaMass:342 DiffAvg: 12.01 DiffFormula: C 1 H 0 N 0 O 0 S 0 DiffMono: 12.000000 Formula: C 4 H 6 N 1 O 1 S 1 MassAvg: 116.16 MassMono: 116.017010 Origin: C Source: artifact TermSpec: N-term thioproline A protein modification that effectively converts an N-terminal L-tryptophan residue by a formadehyde adduct to 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00966 From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Lippke, K. P., W. G. Schunack, W. Wenning, W. E. Mueller. 1983..beta.-Carbolines as benzodiazepine receptor ligands. 1. Synthesis andbenzodiazepine receptor interaction of esters of.beta.-carboline-3-carboxylic acid. J. Med. Chem.26: 499-503 Cain, M., R. W. Weber, F. Guzman, J. M. Cook, S. A. Barker, K. C.Rice, J. N. Crawley, S. M. Paul, P. Skolnick. 1982. .beta.-Carbolines:synthesis and neurochemical and pharmacological actions on brainbenzodiazepine receptors.J. Med. Chem. 25: 1081-91 Notes: +12 Da modification corresponds to formaldehyde adduct of Trp having beta-carboline structure (methylene bridge links carbon-2 of indole ring and alfa-N. See structure at http://www.abrf.org/images/misc/dmass12a.gif; modification in red. 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid MOD:00966 A protein modification that effectively converts an N-terminal L-tryptophan residue by a formadehyde adduct to 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid. DeltaMass:339 DiffAvg: 12.01 DiffFormula: C 1 H 0 N 0 O 0 S 0 DiffMono: 12.000000 Formula: C 12 H 10 N 2 O 1 MassAvg: 198.22 MassMono: 198.079313 Origin: W Source: artifact TermSpec: none A protein modification that effectively cross-links two L-lysine residues to form syndesine, hydroxylysinohydroxynorleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: hydroxylysinohydroxynorleucine PSI-MOD MOD:00967 Cross-link 2; From DeltaMass: Average Mass: 13 Average Mass Change: 13 (incorrect) [JSG]. syndesine MOD:00967 A protein modification that effectively cross-links two L-lysine residues to form syndesine, hydroxylysinohydroxynorleucine. DeltaMass:35 PubMed:75151974 DiffAvg: 16.96 DiffFormula: C 0 H -3 N -2 O 3 DiffMono: 16.955121 Formula: C 12 H 21 N 2 O 5 MassAvg: 273.31 MassMono: 273.145047 Origin: K, K Source: none TermSpec: none hydroxylysinohydroxynorleucine OBSOLETE because this isn't a protein modification, but rather the difference between two known modifications. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00968 From DeltaMass: Average Mass: 13 Formula:C2H2O2 vs C3H5ON Monoisotopic Mass Change:13.03 Average Mass Change:13.05 Notes:Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetic acid e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxymethyl-Cys (CM-Cys, DeltaMass +58Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 13Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. CM-Cys vs PAM-Cys true MOD:00968 OBSOLETE because this isn't a protein modification, but rather the difference between two known modifications. modification from DeltaMass DeltaMass:347 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Source: artifact TermSpec: none OBSOLETE because this isn't a protein modification, but rather the difference between two known modifications. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00969 From DeltaMass: Average Mass: 14 Formula:CH2 Monoisotopic Mass Change:14.016 Average Mass Change:14.027 Notes: Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetamide e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxamidomethyl-Cys (CAM-Cys, DeltaMass +57Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 14Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product. CAM-Cys vs PAM-Cys true MOD:00969 OBSOLETE because this isn't a protein modification, but rather the difference between two known modifications. modification from DeltaMass DeltaMass:346 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00970 From DeltaMass: Average Mass: 15 Average Mass Change:15 Notes:In going from Lys to hydroxy-allysine, two separate reactions are involved:1. the oxidative deamination converting Lys to allysine (-CH2NH2 being converted to -CHO) with a net mass change of -1;2.conversion of allysine to delta-hydroxy-allysine (-CH2-CHO being converted to -CH(OH)-CHO) with a mass change of +16. The net change from Lys to hydroxyallysine thus is +15. delta-hydroxy-allysine (Lys) MOD:00970 modification from DeltaMass DeltaMass:37 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: K Source: natural TermSpec: none A protein modification that effectively converts an L-histidine residue to 2-oxohistidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00971 From DeltaMass: Average Mass: 16 Average Mass Change:16 References:Lewisch, S. A. and Levine, R. L. (1995) Anal. Biochem. 231, 440-446. Determination of 2-oxo-histidine by amino acid analysis Notes:Rod LevineNIHBldg 3, Room 106 MSC 0320Bethesda, MD 20892-0320email: rlevine@nih.govvoice: 1 (301) 496-2310fax: 1 (301) 496-0599 2-Oxohistidine MOD:00971 A protein modification that effectively converts an L-histidine residue to 2-oxohistidine. DeltaMass:38 PubMed:8405458 DiffAvg: 16 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 7 N 3 O 2 MassAvg: 153.14 MassMono: 153.053826 Origin: H Source: natural TermSpec: none A protein modification that effectively converts an L-phenylalanine residue to a monobrominated L-phenylalanine, such as L-2'-bromophenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Br1Phe PSI-MOD Bromo bromination MOD:00972 From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa monobrominated L-phenylalanine MOD:00972 A protein modification that effectively converts an L-phenylalanine residue to a monobrominated L-phenylalanine, such as L-2'-bromophenylalanine. Unimod:340#F DiffAvg: 78.90 DiffFormula: Br 1 C 0 H -1 N 0 O 0 DiffMono: 77.910512 Formula: Br 1 C 9 H 8 N 1 O 1 MassAvg: 226.07 MassMono: 224.978926 Origin: F Source: natural TermSpec: none Unimod: Unimod:340 Br1Phe Bromo bromination modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00973 From DeltaMass: Average Mass: 32 Monoisotopic Mass Change:31.99 Average Mass Change:32 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Rod Levine (unpublished) Oxidation of proline (to glutamic acid) MOD:00973 modification from DeltaMass DeltaMass:355 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: P Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00974 From DeltaMass: Average Mass: 34 (35)Cl labeled 3'-chlorotyrosine MOD:00974 modification from DeltaMass DeltaMass:0 DiffAvg: 33.96 DiffFormula: (35)Cl 1 H -1 DiffMono: 33.961028 Formula: C 9 (35)Cl 1 H 8 N 1 O 2 MassAvg: 197.02 MassMono: 197.024356 Origin: Y Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00975 From DeltaMass: Average Mass: 36 (37)Cl labeled 3'-chlorotyrosine MOD:00975 modification from DeltaMass DeltaMass:0 DiffAvg: 35.96 DiffFormula: (37)Cl 1 H -1 DiffMono: 35.958078 Formula: C 9 (37)Cl 1 H 8 N 1 O 2 MassAvg: 199.02 MassMono: 199.021406 Origin: Y Source: artifact TermSpec: none modification from DeltaMass - OBSOLETE because redundant and identical to MOD:01072. Remap to MOD:01072. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00976 From DeltaMass: Average Mass: 38 potassium salt true MOD:00976 modification from DeltaMass - OBSOLETE because redundant and identical to MOD:01072. Remap to MOD:01072. DeltaMass:0 DiffAvg: 38.09 DiffFormula: H -1 K 1 DiffMono: 37.955882 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:01072 Source: none TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00977 From DeltaMass: Average Mass: 44 disodium salt MOD:00977 modification from DeltaMass DeltaMass:0 DiffAvg: 43.96 DiffFormula: H -2 Na 2 DiffMono: 43.963888 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00978 From DeltaMass: Average Mass: 51 Average Mass Change: 51 References:Lukszo, Patterson, Albericio, and Kates, Letters in Peptide Science 3, 157-166(1996) Notes:The side reaction can be very significant, and the level to which it occurs depends on how the C-terminal Cys is anchored and what the side-chain protecting group is. The mechanism involves piperidine-mediated beta-elimination of sulfur (with the protecting group on), followed by addition of piperidine across the C-terminaldehydroalanine. Since this last-mentioned step creates a chiral center, a mixture of diastereomers is formed which in special cases can be separatedby HPLC. Another problem with C-terminal Cys is racemization; some references in the review article by Andreu, Albericio, Sole, Munson, Ferrer, and Barany in Pennington-Dunn Peptide Synthesis and Purification Protocols, vol 35, 1994, pp. 91-169. piperidine adduct to C-terminal Cys MOD:00978 modification from DeltaMass DeltaMass:345 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00979 From DeltaMass: Average Mass: 56 t-butyl ester (OtBu) and t-butyl (tBu) MOD:00979 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none modification from DeltaMass - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00980 From DeltaMass: Average Mass: 57 Abbreviation:CamCys Formula:C2H3NO Monoisotopic Mass Change:57.021 Average Mass Change:57.051 Notes:Cysteine reacts with iodoacetamide to produce carboxamidomethyl cysteine. Alternative names are often used, such as amidocarboxymethylcysteine and carbamoylmethylcysteine Carboxamidomethyl (on Cysteine) true MOD:00980 modification from DeltaMass - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060. DeltaMass:337 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Remap: MOD:01060 Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00981 From DeltaMass: Average Mass: 60 sodium and potassium salt MOD:00981 modification from DeltaMass DeltaMass:0 DiffAvg: 60.07 DiffFormula: H -2 K 1 Na 1 DiffMono: 59.937826 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none A protein modification that effectively converts an L-serine residue to L-selenocysteine (not known as a natural post-translational modification process). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Sec(Ser) Selenocysteine (from Serine) PSI-MOD MOD:00982 [From DeltaMass: Average Mass: 64.] Although selenocysteine-charged tRNA(Sec) is biosynthesized from serine-charged tRNA(Sec), in peptide work selenocysteine is usually considered as either a natural residue or as a modified cysteine residue. This entry is for the artifactual formation of L-selenocysteine from serine. For encoded L-selenocysteine, use MOD:00031 [JSG]. L-selenocysteine (Ser) MOD:00982 A protein modification that effectively converts an L-serine residue to L-selenocysteine (not known as a natural post-translational modification process). DeltaMass:0 DiffAvg: 62.97 DiffFormula: C 0 H 0 N 0 O -1 Se 1 DiffMono: 63.921607 Formula: C 3 H 5 N 1 O 1 Se 1 MassAvg: 150.05 MassMono: 150.953635 Origin: S Source: artifact TermSpec: none Sec(Ser) Selenocysteine (from Serine) modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00983 From DeltaMass: Average Mass: 67 Average Mass Change:67 References:http://www.abrf.org/archives/hmail/0008/0007.html Notes:1.) Get rid of the DBU. It can cause piperidine amides at Asp residues. The tbu ester side chain comes off during synthesis and the residue is trans-amidated with piperidine (+67Da by MS). If you haven't yet seen this, you will. Even "normal" 20% pip/DMF (NMP) will cause this, but less frequently. Literature exists for this; I don't remember the exact reference. David H. Singleton Scientist Pfizer Central Research PO Box 8118-101 Eastern Point Road Groton, CT 06340 (860)441-4404. Asp transamidation with piperidine MOD:00983 modification from DeltaMass DeltaMass:67 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: D Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00984 From DeltaMass: Average Mass: 68 (35)Cl labeled 3',5'-dichlorotyrosine MOD:00984 modification from DeltaMass DeltaMass:0 DiffAvg: 67.92 DiffFormula: (35)Cl 2 H -2 DiffMono: 67.922055 Formula: C 9 (35)Cl 2 H 7 N 1 O 2 MassAvg: 230.99 MassMono: 230.985384 Origin: Y Source: artifact TermSpec: none A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a halogen atom. Origin: Source: TermSpec: HalTyr PSI-MOD MOD:00985 halogenated tyrosine MOD:00985 A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a halogen atom. PubMed:18688235 Origin: Y Source: none TermSpec: none HalTyr modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00986 From DeltaMass: Average Mass: 70. (35)Cl and (37)Cl labeled 3',5'-dichlorotyrosine MOD:00986 modification from DeltaMass DeltaMass:0 DiffAvg: 69.92 DiffFormula: (35)Cl 1 (37)Cl 1 H -2 DiffMono: 69.919105 Formula: C 9 (35)Cl 1 (37)Cl 1 H 7 N 1 O 2 MassAvg: 232.98 MassMono: 232.982434 Origin: Y Source: artifact TermSpec: none A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a chlorine atom. Origin: Source: TermSpec: ClTyr PSI-MOD MOD:00987 chlorinated tyrosine MOD:00987 A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a chlorine atom. PubMed:18688235 Origin: Y Source: none TermSpec: none ClTyr A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a bromine atom. Origin: Source: TermSpec: BrTyr PSI-MOD MOD:00988 brominated tyrosine MOD:00988 A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a bromine atom. PubMed:18688235 Origin: Y Source: none TermSpec: none BrTyr OBSOLETE because redundant, the difference component of MOD:01079. Remap to MOD:01079. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00989 From DeltaMass with no citation or formula. acetamidomethyl (Acm) true MOD:00989 OBSOLETE because redundant, the difference component of MOD:01079. Remap to MOD:01079. DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Remap: MOD:01079 Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00990 From DeltaMass: Average Mass: 72 (37)Cl labeled 3',5'-dichlorotyrosine MOD:00990 modification from DeltaMass DeltaMass:0 DiffAvg: 71.92 DiffFormula: (37)Cl 2 H -2 DiffMono: 71.916155 Formula: C 9 (37)Cl 2 H 7 N 1 O 2 MassAvg: 234.98 MassMono: 234.979484 Origin: Y Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00991 From DeltaMass: Average Mass: 74 with no citation. S-(sn-1-glyceryl)-L-cysteine MOD:00991 modification from DeltaMass DeltaMass:0 DiffAvg: 74.08 DiffFormula: C 3 H 6 O 2 DiffMono: 74.036779 Formula: C 6 H 11 N 1 O 3 S 1 MassAvg: 177.22 MassMono: 177.045964 Origin: C Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00992 From DeltaMass: Average Mass: 74 Average Mass Change: 74 References: Anal. Biochem. 1993 Vol 208 No. 2 382-386, PubMed:8452236. [DeltaMass] This article only suggests this as a possible modification and does no characterization. Isolation and stuctural evidence for artifactual modification are found in PubMed:18767873 [JSG]. glutamate 5-glycerol ester MOD:00992 modification from DeltaMass DeltaMass:78 PubMed:18767873 DiffAvg: 74.08 DiffFormula: C 3 H 6 O 2 DiffMono: 74.036779 Formula: C 8 H 13 N 1 O 5 MassAvg: 203.19 MassMono: 203.079373 Origin: E Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: OPh PSI-MOD MOD:00993 From DeltaMass: Average Mass: 76, on acidic amino acids phenyl ester MOD:00993 modification from DeltaMass DeltaMass:0 DiffAvg: 76.10 DiffFormula: C 6 H 4 DiffMono: 76.031300 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none OPh modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00994 From DeltaMass: Average Mass: 78 (79)Br labeled 3'-bromotyrosine MOD:00994 modification from DeltaMass DeltaMass:0 DiffAvg: 77.91 DiffFormula: (79)Br 1 H -1 DiffMono: 77.910512 Formula: (79)Br 1 C 9 H 8 N 1 O 2 MassAvg: 240.97 MassMono: 240.973841 Origin: Y Source: artifact TermSpec: none A protein modification that effectively converts an L-phenylalanine residue to (81)Br-L-2'-bromophenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00995 From DeltaMass: Average Mass: 80 (81)Br labeled 2'-bromophenylalanine MOD:00995 A protein modification that effectively converts an L-phenylalanine residue to (81)Br-L-2'-bromophenylalanine. DeltaMass:0 DiffAvg: 79.91 DiffFormula: (81)Br 1 H -1 DiffMono: 79.908466 Formula: (81)Br 1 C 9 H 8 N 1 O 1 MassAvg: 226.98 MassMono: 226.976879 Origin: F Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:00996 From DeltaMass: Average Mass: 80 (81)Br labeled 3'-bromotyrosine MOD:00996 modification from DeltaMass DeltaMass:0 DiffAvg: 79.91 DiffFormula: (81)Br 1 H -1 DiffMono: 79.908466 Formula: (81)Br 1 C 9 H 8 N 1 O 2 MassAvg: 242.97 MassMono: 242.971794 Origin: Y Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: OcHex PSI-MOD MOD:00997 From DeltaMass: Average Mass: 82 cyclohexyl ester MOD:00997 modification from DeltaMass DeltaMass:0 DiffAvg: 82.15 DiffFormula: C 6 H 10 DiffMono: 82.078250 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none OcHex A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with an iodine atom. Origin: Source: TermSpec: ITyr PSI-MOD MOD:00998 iodinated tyrosine MOD:00998 A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with an iodine atom. PubMed:18688235 Origin: Y Source: none TermSpec: none ITyr OBSOLETE because redundant and identical to MOD:00404. Remap to MOD:00404. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:00999 From DeltaMass: Average Mass: 83 Formula:C4H5O1N1 Monoisotopic Mass Change:83.037 Average Mass Change:83.09 homoseryl lactone true MOD:00999 OBSOLETE because redundant and identical to MOD:00404. Remap to MOD:00404. DeltaMass:90 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: M Remap: MOD:00404 Source: artifact TermSpec: none A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one bromine atom. Origin: Source: TermSpec: Br1Tyr PSI-MOD MOD:01000 monobrominated tyrosine MOD:01000 A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one bromine atom. PubMed:18688235 Origin: Y Source: none TermSpec: none Br1Tyr A protein modification that inserts or replaces a residue with a 2-aminoisobutyric acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-amino-2-methylpropanoic acid 2-amino-2-methylpropionic acid 2-methylalanine Aib alpha,alpha-dimethylglycine alpha-aminoisobutyric acid alpha-methylalanine PSI-MOD MOD:01001 Modification from DeltaMass: Average Mass: 85. 2-aminoisobutyric acid residue (Aib) MOD:01001 A protein modification that inserts or replaces a residue with a 2-aminoisobutyric acid. DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 4 H 7 N 1 O 1 MassAvg: 85.11 MassMono: 85.052764 Origin: X Source: artifact TermSpec: none 2-amino-2-methylpropanoic acid 2-amino-2-methylpropionic acid 2-methylalanine Aib alpha,alpha-dimethylglycine alpha-aminoisobutyric acid alpha-methylalanine modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01002 From DeltaMass: Average Mass: 85 Formula: C 4 H 7 O 1 N 1 Monoisotopic Mass Change: 85.053 Average Mass Change: 85.106 gamma-aminobutyryl MOD:01002 modification from DeltaMass DeltaMass:92 DiffAvg: 85.11 DiffFormula: C 4 H 7 N 1 O 1 DiffMono: 85.052764 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01003 From DeltaMass: Average Mass: 86 t-butyloxymethyl (Bum) MOD:01003 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01004 From DeltaMass: Average Mass: 86 Formula: C 3 H 6 O 2 N 1 Monoisotopic Mass Change: 86.048 Average Mass Change: 86.094 diaminopropionyl MOD:01004 modification from DeltaMass DeltaMass:95 DiffAvg: 86.09 DiffFormula: C 3 H 6 N 2 O 1 DiffMono: 86.048013 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: StBu PSI-MOD MOD:01005 From DeltaMass: Average Mass: 88 t-butylsulfenyl MOD:01005 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none StBu A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two bromine atoms. Origin: Source: TermSpec: Unimod: Br2Tyr PSI-MOD Dibromo MOD:01006 dibrominated tyrosine MOD:01006 A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two bromine atoms. Unimod:534 Origin: Y Source: none TermSpec: none Unimod: Unimod:534 Br2Tyr Dibromo Dibromo A protein modification that effectively substitutes an anisyl (methoxyphenyl) group for a hydroxyl group, typically at the 4 or para position. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01007 From DeltaMass with no citation or formula: Average Mass: 90. anisyl modified residue MOD:01007 A protein modification that effectively substitutes an anisyl (methoxyphenyl) group for a hydroxyl group, typically at the 4 or para position. DeltaMass:0 DiffAvg: 90.13 DiffFormula: C 7 H 6 DiffMono: 90.046950 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none A protein modification that effectively substitutes a benzyl (phenylmethyl) group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01008 From DeltaMass with no citation or formula: Average Mass: 90 benzyl (Bzl) and benzyl ester (OBzl) modified residue MOD:01008 A protein modification that effectively substitutes a benzyl (phenylmethyl) group for a hydrogen atom. DeltaMass:0 DiffAvg: 90.13 DiffFormula: C 7 H 6 DiffMono: 90.046950 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01009 From DeltaMass with no citation. dehydrogenated proline MOD:01009 modification from DeltaMass DeltaMass:0 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 5 H 5 N 1 O 1 MassAvg: 95.10 MassMono: 95.037114 Origin: P Source: none TermSpec: none A protein modification that effectively substitutes a trifluoroacetyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: TFA PSI-MOD MOD:01010 trifluoroacetylated residue MOD:01010 A protein modification that effectively substitutes a trifluoroacetyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 96.01 DiffFormula: C 2 F 3 H -1 O 1 DiffMono: 95.982299 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none TFA modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01011 From DeltaMass: Average Mass: 97 N-hydroxysuccinimide (ONSu, OSu) MOD:01011 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none A protein modification that effectively oxidizes the disulfide bond of a cystine crosslink to form two cysteic acid residues. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01012 Cross-link 2. This modification destroys a cross-link. From DeltaMass: Average Mass: 98 Abbreviation: Cya Average Mass Change: 98 Notes: Treatment of cystine by strongly oxidising reagents such as performic acid results in the breakage of the disulphide bond and complete oxidation of the sulphur atoms on each molecule. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure. oxidation of disulfide crosslink in cystine to two cysteic acids MOD:01012 A protein modification that effectively oxidizes the disulfide bond of a cystine crosslink to form two cysteic acid residues. DeltaMass:335 DiffAvg: 98.01 DiffFormula: C 0 H 2 N 0 O 6 S 0 DiffMono: 97.985138 Formula: C 6 H 10 N 2 O 8 S 2 MassAvg: 302.27 MassMono: 301.987857 Origin: MOD:00034 Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01013 From DeltaMass: Average Mass: 98 tetramethylguanidinium termination by-product on amine MOD:01013 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01014 From DeltaMass: Average Mass: 98 Formula:H3PO4 or H2SO4 Monoisotopic Mass Change:97.97 Average Mass Change:98 Notes:Proteins may pick up non-covalent salt adducts during purification. Phosphate and sulphate salts are commonly used and may be observed as +98 amu adducts (or multiples thereof) forming ion pairs with basic residues. Monoisotopic masses H2SO4 97.967, H3PO4 97.977 phosphate/sulphate adduct of proteins MOD:01014 modification from DeltaMass DeltaMass:358 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none A protein modification that inserts or replaces a residue with an isovaline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-amino-2-methylbutanoic acid Isovalyl (-I-,-Iva-) Iva PSI-MOD MOD:01015 isovaline residue (Iva) MOD:01015 A protein modification that inserts or replaces a residue with an isovaline. DeltaMass:110 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 5 H 9 N 1 O 1 MassAvg: 99.13 MassMono: 99.068414 Origin: X Source: artifact TermSpec: none 2-amino-2-methylbutanoic acid Isovalyl (-I-,-Iva-) Iva modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: tBoc PSI-MOD MOD:01016 From DeltaMass: Average Mass: 100 t-butyloxycarbonyl MOD:01016 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none tBoc OBSOLETE because redundant and identical to MOD:00403. Remap to MOD:00403. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01017 From DeltaMass: Average Mass: 101 Abbreviation:-Hse- Formula:C4H7O2N Monoisotopic Mass Change:101.048 Average Mass Change:101.105 homoseryl (-Hse-) true MOD:01017 OBSOLETE because redundant and identical to MOD:00403. Remap to MOD:00403. DeltaMass:113 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: M Remap: MOD:00403 Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Meb PSI-MOD MOD:01018 From DeltaMass: Average Mass: 104 4-methylbenzyl MOD:01018 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Meb modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: HMP PSI-MOD MOD:01019 From DeltaMass: Average Mass: 106 hydroxymethylphenyl linker MOD:01019 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none HMP modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01020 From DeltaMass: Average Mass: 106 thioanisyl MOD:01020 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01021 From DeltaMass: Average Mass: 106 thiocresyl MOD:01021 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none A protein modification that effectively converts an L-lysine residue to 2-piperidinecarboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Pip PSI-MOD MOD:01022 2-piperidinecarboxylic acid MOD:01022 A protein modification that effectively converts an L-lysine residue to 2-piperidinecarboxylic acid. DeltaMass:0 DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 6 H 9 N 1 O 1 MassAvg: 111.14 MassMono: 111.068414 Origin: K Source: artifact TermSpec: none Pip A protein modification that effectively converts an L-tyrosine residue to 3',5'-dibromo-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3',5'-Br2Tyr PSI-MOD MOD:01023 3',5'-dibromo-L-tyrosine MOD:01023 A protein modification that effectively converts an L-tyrosine residue to 3',5'-dibromo-L-tyrosine. DeltaMass:156 DiffAvg: 157.79 DiffFormula: Br 2 C 0 H -2 N 0 O 0 DiffMono: 155.821024 Formula: Br 2 C 9 H 7 N 1 O 2 MassAvg: 320.97 MassMono: 318.884353 Origin: Y Source: none TermSpec: none 3',5'-Br2Tyr A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0149 Hy1Pro Hydroxyproline Hyp hydroxylationp PSI-MOD Oxidation MOD:01024 From DeltaMass: Average Mass: 131. This is the mass of the free amino acid [JSG]. monohydroxylated proline MOD:01024 A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline. DeltaMass:0 OMSSA:62 Unimod:35#P DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 5 H 7 N 1 O 2 MassAvg: 113.12 MassMono: 113.047678 Origin: P Source: natural TermSpec: none Unimod: Unimod:35 Hy1Pro Hydroxyproline Hyp hydroxylationp Oxidation A protein modification that effectively converts an L-tyrosine residue to 3'-bromo-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3'-BrTyr PSI-MOD MOD:01025 3'-bromo-L-tyrosine MOD:01025 A protein modification that effectively converts an L-tyrosine residue to 3'-bromo-L-tyrosine. PubMed:18688235 DiffAvg: 78.90 DiffFormula: Br 1 H -1 DiffMono: 77.910512 Formula: Br 1 C 9 H 8 N 1 O 2 MassAvg: 242.07 MassMono: 240.973841 Origin: Y Source: none TermSpec: none 3'-BrTyr A protein modification that inserts or replaces a residue with a norleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Nle PSI-MOD MOD:01026 norleucine residue (Nle) MOD:01026 A protein modification that inserts or replaces a residue with a norleucine. DeltaMass:126 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 6 H 11 N 1 O 1 MassAvg: 113.16 MassMono: 113.084064 Origin: X Source: artifact TermSpec: none Nle modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Aoc PSI-MOD MOD:01027 From DeltaMass: Average Mass: 114 t-amyloxycarbonyl MOD:01027 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Aoc A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one chlorine atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Cl1Tyr PSI-MOD MOD:01028 monochlorinated L-tyrosine MOD:01028 A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one chlorine atom. PubMed:18688235 DiffAvg: 34.44 DiffFormula: C 0 Cl 1 H -1 N 0 O 0 DiffMono: 33.961028 Formula: C 9 Cl 1 H 8 N 1 O 2 MassAvg: 197.62 MassMono: 197.024356 Origin: Y Source: artifact TermSpec: none Cl1Tyr A protein modification that effectively replaces a hydrogen atom with a succinyl group linked through a carbonyl carbon. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Succinic anhydride labeling reagent light form (N-term & K) MOD:01029 From DeltaMass with no citation or formula, Average Mass: 117 [JSG]. succinylated residue MOD:01029 A protein modification that effectively replaces a hydrogen atom with a succinyl group linked through a carbonyl carbon. DeltaMass:0 Unimod:64 DiffAvg: 100.07 DiffFormula: C 4 H 4 O 3 DiffMono: 100.016044 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:64 Succinic anhydride labeling reagent light form (N-term & K) modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: HOBt PSI-MOD MOD:01030 From DeltaMass: Average Mass: 117 hydroxybenzotriazole ester MOD:01030 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none HOBt modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: diMeBzl PSI-MOD MOD:01031 From DeltaMass: Average Mass: 118 dimethylbenzyl MOD:01031 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none diMeBzl A protein modification that effectively substitutes a benzyloxymethyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Bom PSI-MOD MOD:01032 benzyloxymethyl modified residue MOD:01032 A protein modification that effectively substitutes a benzyloxymethyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 120.15 DiffFormula: C 8 H 8 O 1 DiffMono: 120.057515 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Bom A protein modification that effectively substitutes a p-methoxybenzyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Mbzl Mob PSI-MOD MOD:01033 p-methoxybenzyl modified residue MOD:01033 A protein modification that effectively substitutes a p-methoxybenzyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 120.15 DiffFormula: C 8 H 8 O 1 DiffMono: 120.057515 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Mbzl Mob A protein modification that effectively substitutes a 4-nitrophenyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: ONp p-nitrophenyl PSI-MOD MOD:01034 4-nitrophenyl modified residue MOD:01034 A protein modification that effectively substitutes a 4-nitrophenyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 121.10 DiffFormula: C 6 H 3 N 1 O 2 DiffMono: 121.016378 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none ONp p-nitrophenyl modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: ClBzl PSI-MOD MOD:01035 From DeltaMass: Average Mass: 125 chlorobenzyl MOD:01035 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none ClBzl OBSOLETE because redundant and identical to MOD:01181. Remap to MOD:01181. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01036 From DeltaMass:148 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 129 Formula: C5H7O1N3 Monoisotopic Mass Change: 129.042 Average Mass Change: 129.116 O-methyl aspartyl true MOD:01036 OBSOLETE because redundant and identical to MOD:01181. Remap to MOD:01181. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: D Remap: MOD:01181 Source: none TermSpec: none A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two chlorine atoms. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Cl2Tyr PSI-MOD MOD:01037 dichlorinated tyrosine MOD:01037 A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two chlorine atoms. PubMed:18688235 DiffAvg: 68.88 DiffFormula: C 0 Cl 2 H -2 N 0 O 0 DiffMono: 67.922055 Formula: C 9 Cl 2 H 7 N 1 O 2 MassAvg: 232.06 MassMono: 230.985384 Origin: Y Source: artifact TermSpec: none Cl2Tyr OBSOLETE because this represents a free amino acid and the corresponding residue is MOD:01026. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01038 From DeltaMass: Average Mass: 131. norleucine (Nle) true MOD:01038 OBSOLETE because this represents a free amino acid and the corresponding residue is MOD:01026. DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none OBSOLETE because redundant and identical to MOD:00036. Remap to MOD:00036. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01039 From DeltaMass:152 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 131 Formula:C4H5O1N4 Monoisotopic Mass Change:131.022 Average Mass Change:131.088 hydroxy aspartyl true MOD:01039 OBSOLETE because redundant and identical to MOD:00036. Remap to MOD:00036. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 4 H 5 N 1 O 4 MassAvg: 131.09 MassMono: 131.021858 Origin: D Remap: MOD:00036 Source: none TermSpec: none A protein modification that inserts or replaces a residue with a penicillamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-amino-3-mercapto-3-methylbutanoic acid 2-amino-3-methyl-3-sulfanylbutanoic acid 3,3-dimethylcysteine 3-mercapto-L-valine Pen beta,beta-dimethylcysteine PSI-MOD MOD:01040 From DeltaMass: Name misspelled 'bb-dimethyl cystenyl'. No citation provided. penicillamine residue MOD:01040 A protein modification that inserts or replaces a residue with a penicillamine. DeltaMass:154 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 5 H 9 N 1 O 1 S 1 MassAvg: 131.19 MassMono: 131.040485 Origin: X Source: artifact TermSpec: none 2-amino-3-mercapto-3-methylbutanoic acid 2-amino-3-methyl-3-sulfanylbutanoic acid 3,3-dimethylcysteine 3-mercapto-L-valine Pen Pen beta,beta-dimethylcysteine A protein modification that effectively substitutes a benzyloxycarbonyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Z PSI-MOD MOD:01041 benzyloxycarbonyl modified residue MOD:01041 A protein modification that effectively substitutes a benzyloxycarbonyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 134.13 DiffFormula: C 8 H 6 O 2 DiffMono: 134.036779 Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Z A protein modification that effectively substitutes a adamantyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Ada PSI-MOD MOD:01042 adamantyl modified residue MOD:01042 A protein modification that effectively substitutes a adamantyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 134.22 DiffFormula: C 10 H 14 DiffMono: 134.109550 Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Ada A protein modification that effectively substitutes a p-nitrobenzyl group for the hydrogen atom of a carboxyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: ONb PSI-MOD MOD:01043 p-nitrobenzyl ester modified residue MOD:01043 A protein modification that effectively substitutes a p-nitrobenzyl group for the hydrogen atom of a carboxyl group. DeltaMass:0 DiffAvg: 135.12 DiffFormula: C 7 H 5 N 1 O 2 DiffMono: 135.032028 Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none ONb OBSOLETE because redundant and identical to MOD:00080. Remap to MOD:00080. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01044 From DeltaMass with no citation. Formula:C6H10O2N2 (name misspelled, formula for N5-methylglutaminyl, rather than N2-methylglutamyl) N-methyl glutamyl true MOD:01044 OBSOLETE because redundant and identical to MOD:00080. Remap to MOD:00080. DeltaMass:166 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: Q Remap: MOD:00080 Source: none TermSpec: none A protein modification that effectively converts an L-tyrosine residue to 3',5'-dichloro-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3',5'-Cl2Tyr PSI-MOD MOD:01045 3',5'-dichloro-L-tyrosine MOD:01045 A protein modification that effectively converts an L-tyrosine residue to 3',5'-dichloro-L-tyrosine. PubMed:18688235 DiffAvg: 68.88 DiffFormula: C 0 Cl 2 H -2 N 0 O 0 DiffMono: 67.922055 Formula: C 9 Cl 2 H 7 N 1 O 2 MassAvg: 232.06 MassMono: 230.985384 Origin: Y Source: artifact TermSpec: none 3',5'-Cl2Tyr A protein modification that effectively converts an L-tyrosine residue to 3'-chloro-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3'-ClTyr PSI-MOD MOD:01046 3'-chloro-L-tyrosine MOD:01046 A protein modification that effectively converts an L-tyrosine residue to 3'-chloro-L-tyrosine. PubMed:18688235 DiffAvg: 34.44 DiffFormula: C 0 Cl 1 H -1 N 0 O 0 DiffMono: 33.961028 Formula: C 9 Cl 1 H 8 N 1 O 2 MassAvg: 197.62 MassMono: 197.024356 Origin: Y Source: artifact TermSpec: none 3'-ClTyr A protein modification that effectively converts an L-lysine residue to a monohydroxylated lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Hy1Lys Hydroxy Lysyl (-Hyl-) hydroxylationk PSI-MOD Oxidation MOD:01047 From DeltaMass: Average Mass: 144 Abbreviation:-Hyl- Formula:C6H12N2O2 Monoisotopic Mass Change:144.09 Average Mass Change:144.174. monohydroxylated lysine MOD:01047 A protein modification that effectively converts an L-lysine residue to a monohydroxylated lysine. DeltaMass:168 OMSSA:60 Unimod:35#K DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 12 N 2 O 2 MassAvg: 144.17 MassMono: 144.089878 Origin: K Source: natural TermSpec: none Unimod: Unimod:35 Hy1Lys Hydroxy Lysyl (-Hyl-) hydroxylationk Oxidation A protein modification that effectively converts a source amino acid residue to 2-pyrrolidone-5-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PyrGlu PSI-MOD MOD:01048 From DeltaMass: Average Mass: -18 Average Mass Change: -18.01 References:The conversion of glutamic acid to pyroglutamic was reported for the beta-amiloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52. 2-pyrrolidone-5-carboxylic acid MOD:01048 A protein modification that effectively converts a source amino acid residue to 2-pyrrolidone-5-carboxylic acid. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 5 H 6 N 1 O 2 MassAvg: 112.11 MassMono: 112.039853 Origin: X Source: none TermSpec: N-term PyrGlu A protein modification that effectively substitutes a hydrogen atom of an L-histidine residue with a halogen atom. Origin: Source: TermSpec: HalHis PSI-MOD MOD:01049 halogenated histidine MOD:01049 A protein modification that effectively substitutes a hydrogen atom of an L-histidine residue with a halogen atom. PubMed:18688235 Origin: H Source: none TermSpec: none HalHis modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01050 From DeltaMass: Average Mass: 148 Formula:C8H8O2N1 Monoisotopic Mass Change:148.064 Average Mass Change:148.165 pyridyl alanyl MOD:01050 modification from DeltaMass DeltaMass:180 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: A Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: NBz PSI-MOD MOD:01051 From DeltaMass: Average Mass: 149 2-nitrobenzoyl MOD:01051 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none NBz modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01052 From DeltaMass: Average Mass: 150 dimethoxybenzyl Trp MOD:01052 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: W Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Nps PSI-MOD MOD:01053 From DeltaMass: Average Mass: 153 2-nitrophenylsulphenyl MOD:01053 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Nps modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-toluenesulphonyl Tos Tosyl PSI-MOD MOD:01054 From DeltaMass: Average Mass: 154 4-toluenesulfonyl MOD:01054 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none 4-toluenesulphonyl Tos Tosyl modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Npys PSI-MOD MOD:01055 From DeltaMass: Average Mass: 154 3-nitro-2-pyridinesulfenyl MOD:01055 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Npys modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01056 From DeltaMass: Average Mass: 156 (79)Br labeled 3',5'-dibromotyrosine MOD:01056 modification from DeltaMass DeltaMass:0 DiffAvg: 155.82 DiffFormula: (79)Br 2 C 0 H -2 N 0 O 0 DiffMono: 155.821024 Formula: (79)Br 2 C 9 H 7 N 1 O 2 MassAvg: 318.88 MassMono: 318.884353 Origin: Y Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01057 From DeltaMass: Average Mass: 158 (79)Br and (81)Br labeled 3',5'-dibromotyrosine MOD:01057 modification from DeltaMass DeltaMass:0 DiffAvg: 157.82 DiffFormula: (79)Br 1 (81)Br 1 C 0 H -2 N 0 O 0 DiffMono: 157.818978 Formula: (79)Br 1 (81)Br 1 C 9 H 7 N 1 O 2 MassAvg: 320.88 MassMono: 320.882306 Origin: Y Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Dcb PSI-MOD MOD:01058 From DeltaMass: Average Mass: 159 dichlorobenzyl MOD:01058 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Dcb modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01059 From DeltaMass: Average Mass: 160 (81)Br labeled 3',5'-dibromotyrosine MOD:01059 modification from DeltaMass DeltaMass:0 DiffAvg: 159.82 DiffFormula: (81)Br 2 C 0 H -2 N 0 O 0 DiffMono: 159.816931 Formula: (81)Br 2 C 9 H 7 N 1 O 2 MassAvg: 322.88 MassMono: 322.880260 Origin: Y Source: artifact TermSpec: none A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: CamC CamCys Carboxamidomethyl (on Cysteine) Carboxyamidomethyl Cystenyl S-carbamoylmethyl-L-cysteine amidocarboxymethylcysteine carbamidomethylc carbamoylmethylcysteine PSI-MOD Carbamidomethyl Iodoacetamide derivative MOD:01060 From DeltaMass: (name misspelled "Carboxyamidomethyl Cystenyl") [JSG]. S-carboxamidomethyl-L-cysteine MOD:01060 A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine. DeltaMass:196 DeltaMass:337 OMSSA:3 PubMed:10504701 PubMed:11510821 PubMed:12422359 PubMed:18306178 Unimod:4#C DiffAvg: 57.05 DiffFormula: C 2 H 3 N 1 O 1 S 0 DiffMono: 57.021464 Formula: C 5 H 8 N 2 O 2 S 1 MassAvg: 160.19 MassMono: 160.030649 Origin: C Source: artifact TermSpec: none Unimod: Unimod:4 CamC CamCys Carboxamidomethyl (on Cysteine) Carboxyamidomethyl Cystenyl S-carbamoylmethyl-L-cysteine amidocarboxymethylcysteine carbamidomethylc carbamoylmethylcysteine Carbamidomethyl Iodoacetamide derivative A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Carboxymethyl Cystenyl Carboxymethyl cysteine CmC carboxymethylc PSI-MOD Carboxymethyl Iodoacetic acid derivative MOD:01061 From DeltaMass with no citation, name misspelled "Carboxymethyl Cystenyl", and formula incorrect, N and O reversed: Average Mass: 161 Abbreviation: -Cmc- Formula: C5H7O1N3S1 Monoisotopic Mass Change: 161.015 Average Mass Change: 161.179 [JSG]. S-carboxymethyl-L-cysteine MOD:01061 A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine. DeltaMass:0 DeltaMass:197 OMSSA:2 Unimod:6#C DiffAvg: 58.04 DiffFormula: C 2 H 2 N 0 O 2 S 0 DiffMono: 58.005479 Formula: C 5 H 7 N 1 O 3 S 1 MassAvg: 161.18 MassMono: 161.014664 Origin: C Source: artifact TermSpec: none Unimod: Unimod:6 Carboxymethyl Cystenyl Carboxymethyl cysteine CmC carboxymethylc Carboxymethyl Iodoacetic acid derivative OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Carboxymethyl Cystenyl PSI-MOD MOD:01062 From DeltaMass:197 (Name misspelled "cystenyl", and formula incorrect, N and O reversed) Abbreviation:-Cmc- Formula:C5H7O1N3S1 Monoisotopic Mass Change:161.015 Average Mass Change:161.179 carboxymethyl cysteinyl true MOD:01062 OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061 DeltaMass:197 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 5 H 7 N 3 O 1 S 1 MassAvg: 157.19 MassMono: 157.030983 Origin: C Remap: MOD:01061 Source: artifact TermSpec: none Carboxymethyl Cystenyl A protein modification that effectively converts an L-phenylalanine residue to a monomethylated phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: NMePhe PSI-MOD MOD:01063 From DeltaMass: Average Mass: 161 Formula: C10H11O1N1 Monoisotopic Mass Change: 161.084 Average Mass Change: 161.205. No citation provided. It is not obvious whether the DeltaMass entry is supposed to represent N-methylphenylalanine, alpha-methylphenylalanine, 2'-, 3'-, or 4'-methylphenylalanine [JSG]. monomethylated phenylalanine MOD:01063 A protein modification that effectively converts an L-phenylalanine residue to a monomethylated phenylalanine. DeltaMass:198 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 10 H 11 N 1 O 1 MassAvg: 161.20 MassMono: 161.084064 Origin: F Source: none TermSpec: none NMePhe modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01064 From DeltaMass: Average Mass: 162 inositol MOD:01064 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein N-terminal amino group to form a Schiff-base or an Amadori ketosamine (or aminoketose) residue adduct. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:01065 From DeltaMass: Average Mass: 162 hexose glycated N-terminal MOD:01065 A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein N-terminal amino group to form a Schiff-base or an Amadori ketosamine (or aminoketose) residue adduct. DeltaMass:0 Unimod:41#N-term DiffAvg: 162.14 DiffFormula: C 6 H 10 O 5 DiffMono: 162.052823 Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: N-term Unimod: Unimod:41 A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a halogen atom. Origin: Source: TermSpec: HalPhe PSI-MOD MOD:01066 halogenated phenylalanine MOD:01066 A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a halogen atom. PubMed:18688235 Origin: F Source: none TermSpec: none HalPhe modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01067 From DeltaMass: Average Mass: 162 Average Mass Change:162 Notes: (from the ABRF discussion list archive) There may be ... things in the reagent K that would allow cleavage of the peptide to occur at the wrong place...in this case it removes the dimethoxybenzyl group first inactivating that site for cleavage, and it goes after tne next amide bond closer to the resin. Try the TFA/TIS/water/EDT cocktail...TFA = 92%, TIS =3%, and water is at 5%. .. had this issue on longer peptides.. and by increasing the amount of water a little bit... able to elminate this problem. linker attached to peptide in Fmoc peptide synthesis MOD:01067 modification from DeltaMass DeltaMass:341 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none A protein modification that effectively substitutes a hydrogen atom of an L-tryptophan residue with a halogen atom. Origin: Source: TermSpec: HalTrp PSI-MOD MOD:01068 halogenated tryptophan MOD:01068 A protein modification that effectively substitutes a hydrogen atom of an L-tryptophan residue with a halogen atom. PubMed:18688235 Origin: W Source: none TermSpec: none HalTrp A protein modification that effectively substitutes a 2,4-dinitrophenyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Dnp PSI-MOD MOD:01069 2,4-dinitrophenyl modified residue MOD:01069 A protein modification that effectively substitutes a 2,4-dinitrophenyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 166.09 DiffFormula: C 6 H 2 N 2 O 4 DiffMono: 166.001457 Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Dnp A protein modification that effectively substitutes a pentafluorophenyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Pfp PSI-MOD MOD:01070 From DeltaMass: name mispelled "pentaflourophenyl" pentafluorophenyl modified residue MOD:01070 A protein modification that effectively substitutes a pentafluorophenyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 166.05 DiffFormula: C 6 F 5 H -1 DiffMono: 165.984191 Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Pfp A protein modification that effectively substitutes a diphenylmethyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Dpm PSI-MOD MOD:01071 diphenylmethyl modified residue MOD:01071 A protein modification that effectively substitutes a diphenylmethyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 166.22 DiffFormula: C 13 H 10 DiffMono: 166.078250 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Dpm A protein modification that effectively substitutes one potassium atom for one hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: K1Res PSI-MOD MOD:01072 monopotassium salt MOD:01072 A protein modification that effectively substitutes one potassium atom for one hydrogen atom. DeltaMass:0 DiffAvg: 38.09 DiffFormula: H -1 K 1 DiffMono: 37.955882 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none K1Res A protein modification that effectively substitutes a 2-chlorobenzyloxycarbonyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Clz PSI-MOD MOD:01073 2-chlorobenzyloxycarbonyl modified residue MOD:01073 A protein modification that effectively substitutes a 2-chlorobenzyloxycarbonyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 169.58 DiffFormula: C 8 Cl 1 H 6 O 2 DiffMono: 169.005632 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Clz A protein modification that effectively substitutes a napthylacetyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01074 napthylacetyl modified residue MOD:01074 A protein modification that effectively substitutes a napthylacetyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 169.20 DiffFormula: C 12 H 9 O 1 DiffMono: 169.065340 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none A protein modification that effectively substitutes a mercury atom or a cluster containing mercury for hydrogen atoms, or that coordinates a mercury ion. HgRes PSI-MOD MOD:01075 mercury containing modified residue MOD:01075 A protein modification that effectively substitutes a mercury atom or a cluster containing mercury for hydrogen atoms, or that coordinates a mercury ion. PubMed:18688235 HgRes modification from DeltaMass - OBSOLETE because redundant and identical to MOD:00414. Remap to MOD:00414. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01076 From DeltaMass: Average Mass: 170 Formula:C7H14O4N1 Monoisotopic Mass Change:170.117 Average Mass Change:170.215 N-methyl arginyl true MOD:01076 modification from DeltaMass - OBSOLETE because redundant and identical to MOD:00414. Remap to MOD:00414. DeltaMass:215 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 7 H 14 N 4 O 1 MassAvg: 170.22 MassMono: 170.116761 Origin: R Remap: MOD:00414 Source: none TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01077 From DeltaMass: Average Mass: 172 Average Mass Change:172 References:[1]. Sieber,P.(1987) Modification of tryptophan residues during acidolysis of4-methoxy-2,3,6-trimethylbenzenesulfonyl groups. Effects of scavengers. Tetrahedron Lett., 28(15),1637-1640. Notes: TFA-cyclic dithioketal by-product is formed when Trp-containing peptide is subjected to prolonged TFA/EDT treatment [1]. See structure at http://www.abrf.org/images/misc/dmass172.gif. Additional discussion of this adduct, and how to avoid it, can befound in Methods in Enzymology 289, 67 (1997) ethanedithiol/TFA cyclic adduct MOD:01077 modification from DeltaMass DeltaMass:216 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none A protein modification that effectively converts an L-threonine residue to S-(2-aminoethyl)-3-methylcysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 2-amino-3-(2-aminoethyl)sulfanyl-3-methylbutanoic acid S-aminoethyl-3-methylcysteine PSI-MOD AEC-MAEC beta-methylaminoethylcysteine MOD:01078 From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex. S-(2-aminoethyl)-3-methylcysteine (Thr) MOD:01078 A protein modification that effectively converts an L-threonine residue to S-(2-aminoethyl)-3-methylcysteine. PubMed:12923550 Unimod:472#T DiffAvg: 59.13 DiffFormula: C 2 H 5 N 1 O -1 S 1 DiffMono: 59.019356 Formula: C 6 H 12 N 2 O 1 S 1 MassAvg: 160.24 MassMono: 160.067034 Origin: T Source: artifact TermSpec: none Unimod: Unimod:472 2-amino-3-(2-aminoethyl)sulfanyl-3-methylbutanoic acid S-aminoethyl-3-methylcysteine AEC-MAEC beta-methylaminoethylcysteine A protein modification that effectively converts an L-cysteine residue to S-[(acetylamino)methyl]-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Acetamidomethyl Cystenyl Acm-Cys N-(hydroxymethyl)acetamide derivatized L-cysteine S-(acetamido)methyl-L-cysteine PSI-MOD MOD:01079 From DeltaMass: (name misspelled "Acetamidomethyl Cystenyl") Average Mass: 174 Formula: C 6 H 10 O 2 N 2 S 1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221. [These are aggregate masses, not delta masses.] See Organic Syntheses, Coll. Vol. 6, p.5 (1988); Vol. 59, p.190 (1979); http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv6p0005 [JSG]. S-(acetylamino)methyl-L-cysteine MOD:01079 A protein modification that effectively converts an L-cysteine residue to S-[(acetylamino)methyl]-L-cysteine. DeltaMass:218 PubMed:8572278 DiffAvg: 71.08 DiffFormula: C 3 H 5 N 1 O 1 S 0 DiffMono: 71.037114 Formula: C 6 H 10 N 2 O 2 S 1 MassAvg: 174.22 MassMono: 174.046299 Origin: C Source: artifact TermSpec: none Acetamidomethyl Cystenyl Acm-Cys N-(hydroxymethyl)acetamide derivatized L-cysteine S-(acetamido)methyl-L-cysteine OBSOLETE because this is identical to MOD:00417. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: Acrylamidyl Cystenyl PSI-MOD MOD:01080 From DeltaMass: (name misspelled "Acrylamidyl Cystenyl") Average Mass: 174 Formula: C6H10O2N2S1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221 acrylamidyl cysteinyl true MOD:01080 OBSOLETE because this is identical to MOD:00417. modification from DeltaMass DeltaMass:219 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 6 H 10 N 2 O 2 S 1 MassAvg: 174.22 MassMono: 174.046299 Origin: C Remap: MOD:00417 Source: artifact Acrylamidyl Cystenyl modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01081 From DeltaMass: Average Mass: 177. CAUTION - mass does not match formula. delta-glycosyloxy- (of lysine) or beta-glycosyloxy- (of phenylalanine or tyrosine) MOD:01081 modification from DeltaMass DeltaMass:0 DiffAvg: 178.14 DiffFormula: C 6 H 10 O 6 DiffMono: 178.047738 Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none OBSOLETE because redundant with MOD:00757, remap. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01082 From DeltaMass: Average Mass: 177. Caution: Formula does not match mass. The natural glycosylating sugar of hydroxyproline is galactose. 4-glycosyloxy- (hexosyl, C6) (of proline) true MOD:01082 OBSOLETE because redundant with MOD:00757, remap. modification from DeltaMass DeltaMass:0 DiffAvg: 178.14 DiffFormula: C 6 H 10 O 6 DiffMono: 178.047738 Formula: C 11 H 17 N 1 O 6 MassAvg: 259.26 MassMono: 259.105587 Origin: P Remap: MOD:00757 Source: none TermSpec: none A protein modification that effectively converts an L-serine residue to O-benzyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01083 O-benzyl-L-serine MOD:01083 A protein modification that effectively converts an L-serine residue to O-benzyl-L-serine. DeltaMass:0 DiffAvg: 90.13 DiffFormula: C 7 H 6 DiffMono: 90.046950 Formula: C 10 H 11 N 1 O 2 MassAvg: 177.20 MassMono: 177.078979 Origin: S Source: artifact TermSpec: none A protein modification that by reaction of iodoacetic acid effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxymethyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Carboxymethyl (on Cysteine) PSI-MOD Carboxymethyl Iodoacetic acid derivative MOD:01084 iodoacetic acid derivatized amino-terminal residue MOD:01084 A protein modification that by reaction of iodoacetic acid effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxymethyl group. Unimod:6#N-term DiffAvg: 58.04 DiffFormula: C 2 H 2 O 2 DiffMono: 58.005479 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:6 Carboxymethyl (on Cysteine) Carboxymethyl Iodoacetic acid derivative A protein modification that effectively replaces the N-terminal hydrogen atom of a N-terminal histidine residue with a gluconoyl group linked through a glycosidic bond. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01085 Occurs on His-tagged proteins expresssed in E. coli. From DeltaMass: Average Mass: 178 Formula: C6H10O6 Monoisotopic Mass Change: 178.05 Average Mass Change: 178.14 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. Mass listed here is 179 because it's N-terminal. alpha-N-gluconoylated L-histidine MOD:01085 A protein modification that effectively replaces the N-terminal hydrogen atom of a N-terminal histidine residue with a gluconoyl group linked through a glycosidic bond. modification from DeltaMass DeltaMass:226 PubMed:9918669 DiffAvg: 179.15 DiffFormula: C 6 H 11 O 6 DiffMono: 179.055563 Formula: C 12 H 18 N 3 O 7 MassAvg: 316.29 MassMono: 316.114475 Origin: H Source: natural TermSpec: N-term modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4Nz PSI-MOD MOD:01086 From DeltaMass: Average Mass: 179 p-nitrobenzyloxycarbonyl MOD:01086 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none 4Nz A protein modification that effectively substitutes a 2,4,5-trichlorophenyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01087 2,4,5-trichlorophenyl modified residue MOD:01087 A protein modification that effectively substitutes a 2,4,5-trichlorophenyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 179.42 DiffFormula: C 6 Cl 3 H 1 DiffMono: 177.914383 Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none A protein modification that effectively substitutes a 2,4,6-trimethyloxybenzyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Tmob PSI-MOD MOD:01088 2,4,6-trimethyloxybenzyl modified residue MOD:01088 A protein modification that effectively substitutes a 2,4,6-trimethyloxybenzyl group for a hydrogen atom. DeltaMass:0 DiffAvg: 180.20 DiffFormula: C 10 H 12 O 3 DiffMono: 180.078644 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Tmob modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Xan PSI-MOD MOD:01089 From DeltaMass: Average Mass: 180 xanthyl MOD:01089 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Xan A protein modification that by reaction of iodoacetamide effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxamidomethyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (carbamoylmethyl)amino PSI-MOD Carbamidomethyl Iodoacetamide derivative MOD:01090 iodoacetamide derivatized amino-terminal residue MOD:01090 A protein modification that by reaction of iodoacetamide effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxamidomethyl group. PubMed:11327326 PubMed:11510821 PubMed:12422359 Unimod:4#N-term DiffAvg: 57.05 DiffFormula: C 2 H 3 N 1 O 1 DiffMono: 57.021464 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:4 (carbamoylmethyl)amino Carbamidomethyl Iodoacetamide derivative A protein modification that effectively substitutes one hydrogen atom of an L-phenylalanine residue with one chlorine atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Cl1Phe PSI-MOD MOD:01091 From DeltaMass: Average Mass: 182 Formula:C9H8O1N1Cl1 Monoisotopic Mass Change:181.029 Average Mass Change:181.623 monochlorinated L-phenylalanine MOD:01091 A protein modification that effectively substitutes one hydrogen atom of an L-phenylalanine residue with one chlorine atom. DeltaMass:233 DiffAvg: 34.44 DiffFormula: C 0 Cl 1 H -1 N 0 O 0 DiffMono: 33.961028 Formula: C 9 Cl 1 H 8 N 1 O 1 MassAvg: 181.62 MassMono: 181.029442 Origin: F Source: artifact TermSpec: none Cl1Phe modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Mts PSI-MOD MOD:01092 From DeltaMass: Average Mass: 182 mesitylene-2-sulfonyl MOD:01092 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Mts modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01093 From DeltaMass: Average Mass: 184 Formula: C9H16O2N2 Monoisotopic Mass Change: 184.12 Average Mass Change: 184.24 with no citation. isopropyl lysyl MOD:01093 modification from DeltaMass DeltaMass:236 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 9 H 16 N 2 O 2 MassAvg: 184.24 MassMono: 184.121178 Origin: K Source: artifact TermSpec: none A protein modification that effectively converts an L-lysine residue to N6-carboxymethyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Carboxymethyl Lysyl PSI-MOD Carboxymethyl Iodoacetic acid derivative MOD:01094 From DeltaMass:237 (with no citation, formula incorrect, N and O reversed) Average Mass: 186 Formula: C8H14O2N3 Monoisotopic Mass Change: 186.1 Average Mass Change: 186.211 [JSG]. N6-carboxymethyl-L-lysine MOD:01094 A protein modification that effectively converts an L-lysine residue to N6-carboxymethyl-L-lysine. DeltaMass:237 Unimod:6#K DiffAvg: 58.04 DiffFormula: C 2 H 2 O 2 DiffMono: 58.005479 Formula: C 8 H 14 N 2 O 3 MassAvg: 186.21 MassMono: 186.100442 Origin: K Source: artifact TermSpec: none Unimod: Unimod:6 Carboxymethyl Lysyl Carboxymethyl Iodoacetic acid derivative Modification from DeltaMass. OBSOLETE because not an amino acid modification. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01095 From DeltaMass with no citation, formula incorrect, N and O reversed: Formula: C10H8O1N3 Monoisotopic Mass Change: 190.05 Average Mass Change: 190.18. Matrix alpha cyano MH+ true MOD:01095 Modification from DeltaMass. OBSOLETE because not an amino acid modification. DeltaMass:240 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 10 H 8 N 1 O 3 MassAvg: 190.18 MassMono: 190.050418 Origin: X Source: artifact TermSpec: none A protein modification that effectively converts an L-threonine residue to O-benzyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01096 O-benzyl-L-threonine MOD:01096 A protein modification that effectively converts an L-threonine residue to O-benzyl-L-threonine. DeltaMass:0 DiffAvg: 90.13 DiffFormula: C 7 H 6 DiffMono: 90.046950 Formula: C 11 H 13 N 1 O 2 MassAvg: 191.23 MassMono: 191.094629 Origin: T Source: artifact TermSpec: none A protein modification that effectively converts an L-cysteine residue to S-benzyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01097 From DeltaMass: misspelled "Benzyl Cystenyl". S-benzyl-L-cysteine MOD:01097 A protein modification that effectively converts an L-cysteine residue to S-benzyl-L-cysteine. DeltaMass:242 DiffAvg: 90.13 DiffFormula: C 7 H 6 DiffMono: 90.046950 Formula: C 10 H 11 N 1 O 1 S 1 MassAvg: 193.26 MassMono: 193.056135 Origin: C Source: artifact TermSpec: none A protein modification that inserts or replaces a residue with a naphthylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01098 From DeltaMass: Average Mass: 197 Formula: C13H11O1N1 Monoisotopic Mass Change: 197.084 Average Mass Change: 197.238. No citation provided. It is not obvious which isomer of naphthylalanine this DeltaMass entry is supposed to represent [JSG]. naphthylalanine residue MOD:01098 A protein modification that inserts or replaces a residue with a naphthylalanine. DeltaMass:243 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 13 H 11 N 1 O 1 MassAvg: 197.24 MassMono: 197.084064 Origin: X Source: artifact TermSpec: none A protein modification that effectively converts an L-aspartic acid residue to succinyl beta-aspartyl anhydride. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: succinyl aspartamyl PSI-MOD MOD:01099 From DeltaMass with no citation (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 198 Formula: C8H8O1N5 Monoisotopic Mass Change: 198.04 Average Mass Change: 198.156 [JSG]. succinyl beta-aspartyl anhydride MOD:01099 A protein modification that effectively converts an L-aspartic acid residue to succinyl beta-aspartyl anhydride. DeltaMass:244 DiffAvg: 82.06 DiffFormula: C 4 H 2 N 0 O 2 DiffMono: 82.005479 Formula: C 8 H 8 N 1 O 5 MassAvg: 198.15 MassMono: 198.040247 Origin: D Source: artifact TermSpec: N-term succinyl aspartamyl modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01100 From DeltaMass: Average Mass: 201 with no citation. HMP (hydroxymethylphenyl)/TFA adduct MOD:01100 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none OBSOLETE because erroneous and apparently redundant to MOD:00111. Remap to MOD:00111. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01101 Modification from DeltaMass: Average Mass: 206. This entry with no other information available appears to be the same as the entry at 204 for "Farnesylation" but with an incorrect mass. S-Farnesyl- true MOD:01101 OBSOLETE because erroneous and apparently redundant to MOD:00111. Remap to MOD:00111. DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Remap: MOD:00111 Source: none TermSpec: none OBSOLETE because redundant and identical to MOD:00504. Remap to MOD:00504. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01102 From DeltaMass: Average Mass: 206 Formula: C14 H22 O1 Monoisotopic Mass Change: 206.167 Average Mass Change: 206.324 References: Neubert TA, Johnson RS, Hurley JB, Walsh KA (1992). The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated. J Biol Chem. 267(26), 18274-7. Notes: Modification of protein N-terminus with (cis,cis-delta 5, delta 8)-tetradecadienoyl group (myristoylation with 2 double bonds) myristoylation-4H (two double bonds) true MOD:01102 OBSOLETE because redundant and identical to MOD:00504. Remap to MOD:00504. DeltaMass:348 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Remap: MOD:00504 Source: natural TermSpec: none OBSOLETE because redundant and identical to MOD:00503. Remap to MOD:00503. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01103 From DeltaMass with no citation or formula: Average Mass: 208. myristoleylation (one double bond) true MOD:01103 OBSOLETE because redundant and identical to MOD:00503. Remap to MOD:00503. DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Remap: MOD:00503 Source: natural TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Mtr PSI-MOD MOD:01104 From DeltaMass: Average Mass: 212 with no citation. 4-methoxy-2,3,6-trimethylbenzenesulfonyl MOD:01104 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Mtr modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: BrZ PSI-MOD MOD:01105 From DeltaMass: Average Mass: 213 with no citation. 2-bromobenzyloxycarbonyl MOD:01105 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none BrZ A protein modification that effectively converts an L-tryptophan residue to N-formyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: formyl tryptophanyl PSI-MOD MOD:01106 From DeltaMass with no citation or formula: Average Mass: 214. It is not clear what this is supposed to represent. The mass corresponds to an N-formyl tryptophan (either N2 or N1'), but neither of these modifications has been reported as commonly encountered. It may have been confused with N'-formyl-L-kynurenine, see MOD:00464 [JSG] N-formyl-L-tryptophan MOD:01106 A protein modification that effectively converts an L-tryptophan residue to N-formyl-L-tryptophan. DeltaMass:0 DiffAvg: 28.01 DiffFormula: C 1 H 0 N 0 O 1 DiffMono: 27.994915 Formula: C 12 H 10 N 2 O 2 MassAvg: 214.22 MassMono: 214.074228 Origin: W Source: artifact TermSpec: none formyl tryptophanyl A protein modification that effectively converts an L-glutamic acid residue to O5-benzyl-L-glutamate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01107 From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. O5-benzyl-L-glutamate MOD:01107 A protein modification that effectively converts an L-glutamic acid residue to O5-benzyl-L-glutamate. DeltaMass:258 DiffAvg: 90.13 DiffFormula: C 7 H 6 DiffMono: 90.046950 Formula: C 12 H 13 N 1 O 3 MassAvg: 219.24 MassMono: 219.089543 Origin: E Source: artifact TermSpec: none A protein modification that effectively converts an L-glutamic acid residue to 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid, glutamtic acid anisole adduct. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: anisole adducted glutamyl PSI-MOD MOD:01108 From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG]. 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid (Glu) MOD:01108 A protein modification that effectively converts an L-glutamic acid residue to 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid, glutamtic acid anisole adduct. DeltaMass:259 DiffAvg: 90.13 DiffFormula: C 7 H 6 DiffMono: 90.046950 Formula: C 12 H 13 N 1 O 3 MassAvg: 219.24 MassMono: 219.089543 Origin: E Source: artifact TermSpec: none anisole adducted glutamyl modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01109 From DeltaMass: Average Mass: 222 with no citation. 9-fluorenylmethyloxycarbonyl (Fmoc) MOD:01109 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none A protein modification that effectively replaces a hydrogen atom of an L-cysteine residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: IpCys PSI-MOD MOD:01110 isoprenylated cysteine MOD:01110 A protein modification that effectively replaces a hydrogen atom of an L-cysteine residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20). PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Source: none TermSpec: none IpCys A protein modification that effectively substitutes a dimethoxybenzhydryl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4,4'-dimethoxybenzhydryl Mbh bis(4-methoxyphenyl)methyl PSI-MOD MOD:01111 From DeltaMass: Average Mass: 226 with no citation. A reagent, typically 4,4'-dimethoxybenzhydryl chloride, used as a protecting group for the carboxamido group of asparagine and glutamine during chemical peptide synthesis [JSG]. dimethoxybenzhydryl modified residue MOD:01111 A protein modification that effectively substitutes a dimethoxybenzhydryl group for a hydrogen atom. DeltaMass:0 DiffAvg: 226.27 DiffFormula: C 15 H 14 O 2 DiffMono: 226.099380 Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none 4,4'-dimethoxybenzhydryl Mbh bis(4-methoxyphenyl)methyl modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: nicotinyl lysyl PSI-MOD MOD:01112 From DeltaMass: (name misspelled "nicotinyl"; formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 233 Formula: C12H15O3N2 Monoisotopic Mass Change: 233.116 Average Mass Change: 233.271 nicotinoyl lysine MOD:01112 modification from DeltaMass DeltaMass:266 DiffAvg: 105.10 DiffFormula: C 6 H 3 N 1 O 1 DiffMono: 105.021464 Formula: C 12 H 15 N 3 O 2 MassAvg: 233.27 MassMono: 233.116427 Origin: K Source: artifact TermSpec: none nicotinyl lysyl modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Bpoc PSI-MOD MOD:01113 From DeltaMass: Average Mass: 238 with no citation. 2-(p-biphenyl)isopropyl-oxycarbonyl MOD:01113 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Bpoc modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Trityl Trt PSI-MOD MOD:01114 From DeltaMass: Average Mass: 242 Average Mass Change: 242.3 Notes: blocking group used in peptide synthesis for C,H,Q,N triphenylmethyl MOD:01114 modification from DeltaMass DeltaMass:270 DiffAvg: 242.32 DiffFormula: C 19 H 14 DiffMono: 242.109550 Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Trityl Trt A protein modification that effectively replaces a hydrogen atom of an L-tryptophan residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: IpTrp PSI-MOD MOD:01115 isoprenylated tryptophan MOD:01115 A protein modification that effectively replaces a hydrogen atom of an L-tryptophan residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20). PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: W Source: none TermSpec: none IpTrp A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: SFarnOMeCys PSI-MOD MOD:01116 S-farnesyl-L-cysteine methyl ester MOD:01116 A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester. PubMed:15609361 RESID:AA0102#var RESID:AA0105#var DiffAvg: 218.38 DiffFormula: C 16 H 26 N 0 O 0 S 0 DiffMono: 218.203451 Formula: C 19 H 32 N 1 O 2 S 1 MassAvg: 338.53 MassMono: 338.215375 Origin: C Source: natural TermSpec: C-term SFarnOMeCys modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Pbf PSI-MOD MOD:01117 From DeltaMass: Average Mass: 252 with no citation. pentamethyldihydrobenzofuransulfonyl MOD:01117 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Pbf A protein modification that effectively replaces the N-terminal hydrogen atom of a N-terminal histidine residue with a 6-phosphogluconoyl group linked through a glycosidic bond. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01118 Occurs on His-tagged proteins expresssed in E. coli.From DeltaMass: Average Mass: 258 Formula: C6H10O6HPO3 Monoisotopic Mass Change: 258.01 Average Mass Change: 258.12 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. Mass is one Da higher because this is an N-terminal modification alpha-N-6-phosphogluconoylated L-histidine MOD:01118 A protein modification that effectively replaces the N-terminal hydrogen atom of a N-terminal histidine residue with a 6-phosphogluconoyl group linked through a glycosidic bond. modification from DeltaMass DeltaMass:275 PubMed:9918669 DiffAvg: 259.12 DiffFormula: C 6 H 12 O 9 P 1 DiffMono: 259.021894 Formula: C 12 H 19 N 3 O 10 P 1 MassAvg: 396.27 MassMono: 396.080806 Origin: H Source: natural TermSpec: N-term A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: SGergerOMeCys PSI-MOD MOD:01119 S-geranylgeranyl-L-cysteine methyl ester MOD:01119 A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine methyl ester. PubMed:1483450 PubMed:15609361 RESID:AA0104#var RESID:AA0105#var DiffAvg: 286.50 DiffFormula: C 21 H 34 N 0 O 0 S 0 DiffMono: 286.266051 Formula: C 24 H 40 N 1 O 2 S 1 MassAvg: 406.65 MassMono: 406.277976 Origin: C Source: natural TermSpec: C-term SGergerOMeCys A protein modification that is produced by formation of an adduct with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromene-6-sulfonyl 2,2,5,7,8-pentamethyl-6-chromansulfonyl 2,2,5,7,8-pentamethyl-chromane-6-sulfonyl 2,2,5,7,8-pentamethylchroman-6-sulfonyl 2,2,5,7,8-pentamethylchroman-6-sulphonyl 3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonyl Pmc PmcRes PSI-MOD MOD:01120 From DeltaMass: Average Mass: 266 Notes: blocking group for Arg in peptide synthesis. CAS:112160-39-1 [JSG]. 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue MOD:01120 A protein modification that is produced by formation of an adduct with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride. DeltaMass:0 DiffAvg: 266.36 DiffFormula: C 14 H 18 O 3 S 1 DiffMono: 266.097665 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none 2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromene-6-sulfonyl 2,2,5,7,8-pentamethyl-6-chromansulfonyl 2,2,5,7,8-pentamethyl-chromane-6-sulfonyl 2,2,5,7,8-pentamethylchroman-6-sulfonyl 2,2,5,7,8-pentamethylchroman-6-sulphonyl 3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonyl Pmc PmcRes modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Mmt PSI-MOD MOD:01121 From DeltaMass: Average Mass: 272 Average Mass Change: 272 monomethoxytrityl MOD:01121 modification from DeltaMass DeltaMass:280 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none Mmt OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01122 From DeltaMass: Average Mass: 289 with no citation. 5'phos dCytidinyl true MOD:01122 OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none OBSOLETE because redundant and identical to MOD:01123. Remap to MOD:01123. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01123 From DeltaMass: Average Mass: 289 monoiodated tyrosine true MOD:01123 OBSOLETE because redundant and identical to MOD:01123. Remap to MOD:01123. DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: Y Remap: MOD:01123 Source: none TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01124 From DeltaMass: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 290 Formula: C12H22O2N6 Monoisotopic Mass Change: 290.148 Average Mass Change: 290.317 aldohexosyl lysyl MOD:01124 modification from DeltaMass DeltaMass:285 DiffAvg: 162.14 DiffFormula: C 6 H 10 N 0 O 5 DiffMono: 162.052823 Formula: C 12 H 22 N 2 O 6 MassAvg: 290.32 MassMono: 290.147786 Origin: K Source: none TermSpec: none OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01125 From DeltaMass: Average Mass: 304 with no citation. 5'phos dThymidinyl true MOD:01125 OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01126 From DeltaMass: Average Mass: 305 with no citation. 5'phos Cytidinyl true MOD:01126 OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none OBSOLETE because redundant and identical to MOD:01166. Remap to MOD:01166. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01127 From DeltaMass: Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 5'phos Uridinyl true MOD:01127 OBSOLETE because redundant and identical to MOD:01166. Remap to MOD:01166. DeltaMass:292 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Remap: MOD:01166 Source: none TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: NeuGc PSI-MOD MOD:01128 From DeltaMass: Average Mass: 307 with no citation. N-glycolneuraminic acid MOD:01128 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none NeuGc OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01129 From DeltaMass: Average Mass: 313 Formula: C10H12O5N5P1 Monoisotopic Mass Change: 313.058 Average Mass Change: 313.211 5'phos dAdenosyl true MOD:01129 OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DeltaMass:295 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01130 From DeltaMass: Average Mass: 327 Formula: C17H17O3N4 Monoisotopic Mass Change: 327.122 Average Mass Change: 327.342 SucPhencarb Lysyl MOD:01130 modification from DeltaMass DeltaMass:297 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01131 From DeltaMass: Average Mass: 329 5'phos dGuanosyl true MOD:01131 OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none OBSOLETE because redundant and identical to MOD:01165. Remap to MOD:01165. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01132 From DeltaMass: Average Mass: 329 5'phos Adenosinyl true MOD:01132 OBSOLETE because redundant and identical to MOD:01165. Remap to MOD:01165. DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Remap: MOD:01165 Source: none TermSpec: none A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: S12HyFarnOMeCys PSI-MOD MOD:01133 S-12-hydroxyfarnesyl-L-cysteine methyl ester MOD:01133 A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine methyl ester. PubMed:17790543 RESID:AA0103#var RESID:AA0105#var DiffAvg: 234.38 DiffFormula: C 16 H 26 N 0 O 1 S 0 DiffMono: 234.198365 Formula: C 19 H 32 N 1 O 3 S 1 MassAvg: 354.53 MassMono: 354.210290 Origin: C Source: natural TermSpec: C-term S12HyFarnOMeCys modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01134 From DeltaMass: Average Mass: 359 Formula: C21H11O6 Monoisotopic Mass Change: 359.055 Average Mass Change: 359.315 Notes: Using the DHB matrix at low pH the carboxyl group and one of the oxygens on the flurorescein molecule are protinated so the delta mass is 2Da higher than most text book illustrations would indicate. See Bioconjugate Techniques by Greg Hermanson, Academic Press, page 305, figure 204. Text books of course just show the coupling reaction at neutral or basic pH. fluorescein labelling of peptide N-terminal using NHS ester MOD:01134 modification from DeltaMass DeltaMass:306 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01135 From DeltaMass: Average Mass: 365 with no citation. Hex-HexNAc MOD:01135 modification from DeltaMass DeltaMass:0 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: none TermSpec: none OBSOLETE because this is a small molecule contaminant and not a modification to a polypeptide. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01136 From DeltaMass: Average Mass: 391 Average Mass Change: 391 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. dioctyl phthalate true MOD:01136 OBSOLETE because this is a small molecule contaminant and not a modification to a polypeptide. modification from DeltaMass DeltaMass:309 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none A protein modification that is produced by reaction of a lysine residue with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PMC lysyl PmcLys PSI-MOD MOD:01137 From DeltaMass: Average Mass: Formula: C20H30O2N4S1 Monoisotopic Mass Change: 394.192 Average Mass Change: 394.534 N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine MOD:01137 A protein modification that is produced by reaction of a lysine residue with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine. DeltaMass:310 DiffAvg: 266.36 DiffFormula: C 14 H 18 O 3 S 1 DiffMono: 266.097665 Formula: C 20 H 30 N 2 O 4 S 1 MassAvg: 394.53 MassMono: 394.192628 Origin: K Source: artifact TermSpec: none PMC lysyl PmcLys OBSOLETE because no evidence has been seen for this protein modification. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01138 [probably aminoethyldansyl, JSG] From DeltaMass: (name misspelled "Aedans Cystenyl", and formula incorrect, N and O reversed) Average Mass: 409 Abbreviation: Aedans-Cys Formula: C17H19O3N5S2 Monoisotopic Mass Change: 409.077 Average Mass Change: 409.482 Aedans Cystenyl true MOD:01138 OBSOLETE because no evidence has been seen for this protein modification. modification from DeltaMass DeltaMass:311 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Source: artifact TermSpec: none OBSOLETE because this is a MS contaminant, not a known modification to a polypeptide. modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01139 From DeltaMass: Mass: Average Mass Change: 413 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413. dioctyl phthalate sodium adduct true MOD:01139 OBSOLETE because this is a MS contaminant, not a known modification to a polypeptide. modification from DeltaMass DeltaMass:312 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: none Source: artifact TermSpec: none A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two iodine atoms. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3,5-Diiodination (of Tyrosine) I2Tyr diiodinationy PSI-MOD Diiodo di-Iodination MOD:01140 diiodinated tyrosine MOD:01140 A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two iodine atoms. DeltaMass:0 OMSSA:35 PubMed:15627961 Unimod:130#Y DiffAvg: 251.79 DiffFormula: C 0 H -2 I 2 N 0 O 0 DiffMono: 251.793295 Formula: C 9 H 7 I 2 N 1 O 2 MassAvg: 414.97 MassMono: 414.856624 Origin: Y Source: natural TermSpec: none Unimod: Unimod:130 3,5-Diiodination (of Tyrosine) I2Tyr diiodinationy Diiodo di-Iodination A protein modification that is produced by reaction with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PMC arginyl PmcArg PSI-MOD MOD:01141 From DeltaMass: Average Mass: Formula: C20H30O4N4S1 Monoisotopic Mass Change: 422.199 Average Mass Change: 422.547 omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine MOD:01141 A protein modification that is produced by reaction with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine. DeltaMass:314 DiffAvg: 266.36 DiffFormula: C 14 H 18 O 3 S 1 DiffMono: 266.097665 Formula: C 20 H 30 N 4 O 4 S 1 MassAvg: 422.54 MassMono: 422.198776 Origin: R Source: artifact TermSpec: none PMC arginyl PmcArg A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound 15,16-dihydrobiliverdin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (16R)-18-ethenyl-8,12-bis(2-carboxyethyl)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione 15,16-Dhbv 15,16-dihydrobiliverdin IXalpha 15,16-dihydrobiliverdin cysteine adduct 18-ethenyl-8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione 3'-cysteinyl-15,16-dihydrobiliverdin 3alpha-cysteinyl-15,16-dihydrobiliverdin BINDING 15,16-dihydrobiliverdin (covalent; via 1 link) DBV S-15,16-dihydrobiliverdin-L-cysteine PSI-MOD MOD:01142 S-15,16-dihydrobiliverdin-L-cysteine MOD:01142 A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound 15,16-dihydrobiliverdin. PubMed:10430868 PubMed:15504407 PubMed:1559975 PubMed:3208761 RESID:AA0428 DiffAvg: 584.67 DiffFormula: C 33 H 36 N 4 O 6 S 0 DiffMono: 584.263485 Formula: C 36 H 41 N 5 O 7 S 1 MassAvg: 687.81 MassMono: 687.272670 Origin: C Source: natural TermSpec: none (16R)-18-ethenyl-8,12-bis(2-carboxyethyl)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione 15,16-Dhbv 15,16-dihydrobiliverdin IXalpha 15,16-dihydrobiliverdin cysteine adduct 18-ethenyl-8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione 3'-cysteinyl-15,16-dihydrobiliverdin 3alpha-cysteinyl-15,16-dihydrobiliverdin BINDING 15,16-dihydrobiliverdin (covalent; via 1 link) DBV S-15,16-dihydrobiliverdin-L-cysteine A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound 15,16-dihydrobiliverdin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (16R)-8,12-bis(2-carboxyethyl)-3-[2-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-[(1Xi)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione 15,16-Dhbv 15,16-dihydrobiliverdin IXalpha 15,16-dihydrobiliverdin cysteine adduct 15,16-dihydrobiliverdin-bis-L-cysteine 3'',18'-biscysteinyl-15,16-dihydrobiliverdin 3beta,18alpha-biscysteinyl-15,16-dihydrobiliverdin 8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-18-(1-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione BINDING 15,16-dihydrobiliverdin (covalent; via 2 links) DBV PSI-MOD MOD:01143 Cross-link 2. 15,16-dihydrobiliverdin-bis-L-cysteine MOD:01143 A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound 15,16-dihydrobiliverdin. PubMed:1559975 PubMed:2222853 PubMed:3208761 PubMed:8420941 RESID:AA0429 DiffAvg: 584.67 DiffFormula: C 33 H 36 N 4 O 6 S 0 DiffMono: 584.263485 Formula: C 39 H 46 N 6 O 8 S 2 MassAvg: 790.95 MassMono: 790.281854 Origin: C, C Source: natural TermSpec: none (16R)-8,12-bis(2-carboxyethyl)-3-[2-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-[(1Xi)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione 15,16-Dhbv 15,16-dihydrobiliverdin IXalpha 15,16-dihydrobiliverdin cysteine adduct 15,16-dihydrobiliverdin-bis-L-cysteine 3'',18'-biscysteinyl-15,16-dihydrobiliverdin 3beta,18alpha-biscysteinyl-15,16-dihydrobiliverdin 8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-18-(1-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione BINDING 15,16-dihydrobiliverdin (covalent; via 2 links) DBV A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: S-(sn-1-Dipalmitoyl-glyceryl)- (on Cysteine) PSI-MOD MOD:01144 From DeltaMass: Average Mass: 524 S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine MOD:01144 A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine. DeltaMass:0 PubMed:10896212 PubMed:4575979 PubMed:9056182 RESID:AA0107#var DiffAvg: 550.91 DiffFormula: C 35 H 66 N 0 O 4 S 0 DiffMono: 550.496111 Formula: C 38 H 71 N 1 O 5 S 1 MassAvg: 654.05 MassMono: 653.505295 Origin: C Source: natural TermSpec: none S-(sn-1-Dipalmitoyl-glyceryl)- (on Cysteine) A protein modification that effectively converts an L-histidine residue to N-tau-(ADP-ribosyl)diphthamide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0672 MOD_RES ADP-ribosyldiphthamide PSI-MOD MOD:01145 From DeltaMass: (name misspelled "N theta -(ADP-ribosyl) diphthamide (of Histidine)") Average Mass: 648 N-tau-(ADP-ribosyl)diphthamide MOD:01145 A protein modification that effectively converts an L-histidine residue to N-tau-(ADP-ribosyl)diphthamide. ChEBI:82697 DeltaMass:0 DiffAvg: 684.51 DiffFormula: C 22 H 36 N 7 O 14 P 2 DiffMono: 684.178999 FormalCharge: 1+ Formula: C 28 H 43 N 10 O 15 P 2 MassAvg: 821.65 MassMono: 821.237910 Origin: H Source: natural TermSpec: none MOD_RES ADP-ribosyldiphthamide A protein modification that effectively converts an L-cysteine residue to S-(6-FAD)-L-cystine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: S6FADCys PSI-MOD FAD MOD:01146 From DeltaMass: Average Mass: 784 with no citation. This modification has not been reported [JSG]. S-(6-FAD)-L-cysteine MOD:01146 A protein modification that effectively converts an L-cysteine residue to S-(6-FAD)-L-cystine. DeltaMass:0 DiffAvg: 783.54 DiffFormula: C 27 H 31 N 9 O 15 P 2 S 0 DiffMono: 783.141485 Formula: C 30 H 36 N 10 O 16 P 2 S 1 MassAvg: 886.68 MassMono: 886.150669 Origin: C Source: hypothetical TermSpec: none S6FADCys FAD modification from DeltaMass DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:01147 From DeltaMass: Average Mass: 1,039 dHex1Hex3HexNAc2 N4-glycosylated asparagine MOD:01147 modification from DeltaMass DeltaMass:0 Unimod:1761 DiffAvg: 1038.95 DiffFormula: C 40 H 66 N 2 O 29 DiffMono: 1038.375124 Formula: C 44 H 72 N 4 O 31 GNOme: GNO:G20956ZV MassAvg: 1153.06 MassMono: 1152.418052 Origin: N Source: natural TermSpec: none Unimod: Unimod:1761 A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin. Origin: Source: TermSpec: PSI-MOD MOD:01148 ubiquitinylated lysine MOD:01148 A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin. PubMed:11125103 PubMed:18688235 Origin: K Source: natural TermSpec: none A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein. Origin: Source: TermSpec: PSI-MOD MOD:01149 sumoylated lysine MOD:01149 A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein. PubMed:12612601 PubMed:18688235 Origin: K Source: natural TermSpec: none A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein. Origin: Source: TermSpec: PSI-MOD MOD:01150 neddylated lysine MOD:01150 A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein. PubMed:11125103 PubMed:12612601 PubMed:18688235 Origin: K Source: natural TermSpec: none Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid phosphorylated residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01151 phosphorylated residue with neutral loss of phosphate MOD:01151 Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid phosphorylated residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment. PubMed:18688235 DiffAvg: -97.99 DiffFormula: C 0 H -3 N 0 O -4 P -1 DiffMono: -97.976895 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none A protein modification that effectively replaces a hydrogen atom with a carboxylic acid group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Carboxy Carboxylation MOD:01152 carboxylated residue MOD:01152 A protein modification that effectively replaces a hydrogen atom with a carboxylic acid group. Unimod:299 DiffAvg: 44.01 DiffFormula: C 1 H 0 N 0 O 2 DiffMono: 43.989829 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:299 Carboxy Carboxylation A protein modification that effectively replaces a hydrogen atom with an methylsulfanyl group (thiomethyl group). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Beta-methylthiolation Methylthio MOD:01153 methylthiolated residue MOD:01153 A protein modification that effectively replaces a hydrogen atom with an methylsulfanyl group (thiomethyl group). Unimod:39 DiffAvg: 46.09 DiffFormula: C 1 H 2 N 0 O 0 S 1 DiffMono: 45.987721 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:39 Beta-methylthiolation Methylthio A protein modification that effectively converts a source amino acid to pyruvic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-oxopropanoic acid MOD_RES Pyruvic acid (Cys) MOD_RES Pyruvic acid (Ser) pyruvic acid PSI-MOD MOD:01154 pyruvic acid MOD:01154 A protein modification that effectively converts a source amino acid to pyruvic acid. PubMed:10085076 PubMed:3042771 PubMed:8464063 RESID:AA0127 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 3 H 3 O 2 MassAvg: 71.06 MassMono: 71.013304 Origin: X Source: none TermSpec: N-term 2-oxopropanoic acid MOD_RES Pyruvic acid (Cys) MOD_RES Pyruvic acid (Ser) pyruvic acid A protein modification that effectively results from forming an adduct with a compound containing a lipid-like group either through acylation, alkylation, or amidation. PSI-MOD MOD:01155 lipoconjugated residue MOD:01155 A protein modification that effectively results from forming an adduct with a compound containing a lipid-like group either through acylation, alkylation, or amidation. PubMed:18688235 Modified amino acid residue derived from a natural amino acid by a real or hypothetical chemical process. PSI-MOD MOD:01156 protein modification categorized by chemical process MOD:01156 Modified amino acid residue derived from a natural amino acid by a real or hypothetical chemical process. PubMed:18688235 A protein modification considered either as modified amino acid residues derived from natural amino acids, as a replacement by another natural amino acid, or as a replacement by an unnatural amino acid. PSI-MOD MOD:01157 protein modification categorized by amino acid modified MOD:01157 A protein modification considered either as modified amino acid residues derived from natural amino acids, as a replacement by another natural amino acid, or as a replacement by an unnatural amino acid. PubMed:18688235 A protein modification that modifies an L-selenocysteine residue. Origin: PSI-MOD MOD:01158 modified L-selenocysteine residue MOD:01158 A protein modification that modifies an L-selenocysteine residue. PubMed:18688235 Origin: U A protein modification that effectively attaches a residue to murein peptidoglycan by either a pentaglycine linker peptide or a peptide-like L-alanyl-D-glutamyl-2,6-diaminopimelic acid linkage. Origin: Source: TermSpec: PSI-MOD MOD:01159 peptidoglycanated residue MOD:01159 A protein modification that effectively attaches a residue to murein peptidoglycan by either a pentaglycine linker peptide or a peptide-like L-alanyl-D-glutamyl-2,6-diaminopimelic acid linkage. PubMed:18688235 Origin: X Source: natural TermSpec: none A protein modification that effectively results in the loss of an ammonia, usually by a process of vicinal dehydration, rearrangement, and rehydration with release of ammonia, resulting in a loss of nitrogen with no gain of oxygen. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Ammonia-loss Loss of ammonia MOD:01160 deaminated residue MOD:01160 A protein modification that effectively results in the loss of an ammonia, usually by a process of vicinal dehydration, rearrangement, and rehydration with release of ammonia, resulting in a loss of nitrogen with no gain of oxygen. Unimod:385 DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:385 Ammonia-loss Loss of ammonia A protein modification that effectively removes oxygen atoms from a residue without the removal of hydrogen atoms. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: dOxyRes PSI-MOD Deoxy reduction MOD:01161 deoxygenated residue MOD:01161 A protein modification that effectively removes oxygen atoms from a residue without the removal of hydrogen atoms. PubMed:14235557 Unimod:447 DiffAvg: -16.00 DiffFormula: C 0 H 0 N 0 O -1 DiffMono: -15.994915 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:447 dOxyRes Deoxy reduction modification from Unimod N-linked glycosylation DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Fucosylated biantennary dHex(1)Hex(5)HexNAc(4) MOD:01162 fucosylated biantennary MOD:01162 modification from Unimod N-linked glycosylation Unimod:308 DiffAvg: 1769.62 DiffFormula: C 68 H 112 N 4 O 49 DiffMono: 1768.639516 Formula: C 72 H 118 N 6 O 51 GNOme: GNO:G83555HU MassAvg: 1883.73 MassMono: 1882.682443 Origin: N Source: natural TermSpec: none Unimod: Unimod:308 Fucosylated biantennary dHex(1)Hex(5)HexNAc(4) A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoguanosine through either a phosphodiester or a phosphoramide bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 5'phos Guanosyl PSI-MOD Phosphoguanosine phospho-guanosine MOD:01163 From DeltaMass: (formula incorrect, N and O reversed) Average Mass: 345 Formula: C10H12O5N7P1 Monoisotopic Mass Change: 345.047 Average Mass Change: 345.209. guanylated residue MOD:01163 A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoguanosine through either a phosphodiester or a phosphoramide bond. DeltaMass:304 Unimod:413 DiffAvg: 345.21 DiffFormula: C 10 H 12 N 5 O 7 P 1 DiffMono: 345.047434 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:413 5'phos Guanosyl Phosphoguanosine phospho-guanosine A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through a phosphodiester bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD FMN O3-(riboflavin phosphoryl) MOD:01164 riboflavin-phosphorylated residue MOD:01164 A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through a phosphodiester bond. Unimod:442 DiffAvg: 438.33 DiffFormula: C 17 H 19 N 4 O 8 P 1 DiffMono: 438.094050 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:442 FMN O3-(riboflavin phosphoryl) A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoadenosine through either a phosphodiester or a phosphoramide bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 5'phos Adenosinyl PSI-MOD AMP binding site Phosphoadenosine MOD:01165 From DeltaMass: (name misspelled "5'phos adenosinyl") Average Mass: 329 adenylated residue MOD:01165 A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoadenosine through either a phosphodiester or a phosphoramide bond. DeltaMass:0 Unimod:405 DiffAvg: 329.21 DiffFormula: C 10 H 12 N 5 O 6 P 1 DiffMono: 329.052520 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:405 5'phos Adenosinyl AMP binding site Phosphoadenosine A protein modification that effectively crosslinks an amino acid residue and 5'-phosphouridine through either a phosphodiester or a phosphoramide bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 5'phos Uridinyl PSI-MOD PhosphoUridine uridine phosphodiester MOD:01166 From DeltaMass: (name misspelled "5'phos Uridinyl" and formula incorrect, N and O reversed) Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17 uridylated residue MOD:01166 A protein modification that effectively crosslinks an amino acid residue and 5'-phosphouridine through either a phosphodiester or a phosphoramide bond. DeltaMass:292 Unimod:417 DiffAvg: 306.17 DiffFormula: C 9 H 11 N 2 O 8 P 1 DiffMono: 306.025302 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:417 5'phos Uridinyl PhosphoUridine uridine phosphodiester modification from Unimod DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MolybdopterinGD molybdenum bis(molybdopterin guanine dinucleotide) MOD:01167 molybdopterin guanine dinucleotide MOD:01167 modification from Unimod Unimod:424 DiffAvg: 1572.02 DiffFormula: C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 DiffMono: 1572.985775 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:424 MolybdopterinGD molybdenum bis(molybdopterin guanine dinucleotide) A protein modification that effectively converts a source amino acid residue to dehydroalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dha MOD_RES 2,3-didehydroalanine (Cys) MOD_RES 2,3-didehydroalanine (Ser) anhydroserine dHAla dehydroalanine PSI-MOD MOD:01168 dehydroalanine MOD:01168 A protein modification that effectively converts a source amino acid residue to dehydroalanine. PubMed:10220322 PubMed:1547888 PubMed:1815586 PubMed:2914619 PubMed:6838602 PubMed:7947813 PubMed:8239649 RESID:AA0181 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 3 H 3 N 1 O 1 MassAvg: 69.06 MassMono: 69.021464 Origin: X Source: natural TermSpec: none 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dha MOD_RES 2,3-didehydroalanine (Cys) MOD_RES 2,3-didehydroalanine (Ser) anhydroserine dHAla dehydroalanine A protein modification that effectively converts a source amino acid residue to L-oxoalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-3-oxopropanoic acid 2-amino-3-oxopropionic acid L-3-oxoalanine L-amino-malonic acid semialdehyde L-aminomalonaldehydic acid MOD_RES 3-oxoalanine (Cys) MOD_RES 3-oxoalanine (Ser) PSI-MOD C(alpha)-formylglycine L-serinesemialdehyde MOD:01169 L-3-oxoalanine MOD:01169 A protein modification that effectively converts a source amino acid residue to L-oxoalanine. DeltaMass:349 PubMed:14563551 PubMed:7628016 PubMed:8681943 PubMed:9478923 RESID:AA0185 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 3 H 3 N 1 O 2 MassAvg: 85.06 MassMono: 85.016378 Origin: X Source: natural TermSpec: none (S)-2-amino-3-oxopropanoic acid 2-amino-3-oxopropionic acid L-3-oxoalanine L-amino-malonic acid semialdehyde L-aminomalonaldehydic acid MOD_RES 3-oxoalanine (Cys) MOD_RES 3-oxoalanine (Ser) C(alpha)-formylglycine L-serinesemialdehyde A protein modification that effectively forms a 2-ketoimine of pyruvicacid with a residue amino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD N-pyruvic acid 2-iminyl PyruvicAcidIminyl MOD:01170 pyruvic acid iminylated residue MOD:01170 A protein modification that effectively forms a 2-ketoimine of pyruvicacid with a residue amino group. Unimod:422 DiffAvg: 70.05 DiffFormula: C 3 H 2 N 0 O 2 DiffMono: 70.005479 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: N-term Unimod: Unimod:422 N-pyruvic acid 2-iminyl PyruvicAcidIminyl A protein modification that effectively converts an L-threonine residue to O-acetyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0233 (2S,3R)-3-(acetyloxy)-2-aminobutanoic acid ACT_SITE O-acetylthreonine intermediate MOD_RES O-acetylthreonine O-acetyl-L-threonine O-acetylthreonine OAcThr threonine acetate ester PSI-MOD Acetylation MOD:01171 O-acetyl-L-threonine MOD:01171 A protein modification that effectively converts an L-threonine residue to O-acetyl-L-threonine. PubMed:16728640 RESID:AA0423 Unimod:1#T DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: C 6 H 9 N 1 O 3 MassAvg: 143.14 MassMono: 143.058243 Origin: T Source: natural TermSpec: none Unimod: Unimod:1 (2S,3R)-3-(acetyloxy)-2-aminobutanoic acid ACT_SITE O-acetylthreonine intermediate MOD_RES O-acetylthreonine O-acetyl-L-threonine O-acetylthreonine OAcThr threonine acetate ester Acetylation A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylsphingolipidinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0144 GSIAla LIPID GPI-like-anchor amidated alanine N-alanyl-glycosylsphingolipidinositolethanolamine PSI-MOD MOD:01172 N-alanyl-glycosylsphingolipidinositolethanolamine MOD:01172 A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylsphingolipidinositolethanolamine. PubMed:12626404 RESID:AA0424 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 5 H 12 N 2 O 5 P 1 MassAvg: 211.13 MassMono: 211.048383 Origin: A Source: hypothetical TermSpec: C-term GSIAla LIPID GPI-like-anchor amidated alanine N-alanyl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylsphingolipidinositolethanolamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0145 GSIAsn LIPID GPI-like-anchor amidated asparagine N-asparaginyl-glycosylsphingolipidinositolethanolamine PSI-MOD MOD:01173 N-asparaginyl-glycosylsphingolipidinositolethanolamine MOD:01173 A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylsphingolipidinositolethanolamine. PubMed:12626404 RESID:AA0425 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 6 H 13 N 3 O 6 P 1 MassAvg: 254.16 MassMono: 254.054197 Origin: N Source: hypothetical TermSpec: C-term GSIAsn LIPID GPI-like-anchor amidated asparagine N-asparaginyl-glycosylsphingolipidinositolethanolamine A protein modification that effectively converts an L-cysteine residue to S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0447 (2R)-2-amino-3-([(5Z,9Xi,12E,14Z)-1-hydroxy-1,11-oxoprosta-5,12,14-trien-9-yl]sulfanyl)propanoic acid (5Z,9Xi,12E,14Z)-9-([(2R)-2-amino-3-carboxyethyl]sulfanyl)-11-oxoprosta-5,12,14-trien-1-oic acid LIPID S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine PG-J2Cys S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine PSI-MOD MOD:01174 S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine MOD:01174 A protein modification that effectively converts an L-cysteine residue to S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine. ChEBI:27485 PubMed:11466314 PubMed:12684535 RESID:AA0426 DiffAvg: 316.44 DiffFormula: C 20 H 28 N 0 O 3 S 0 DiffMono: 316.203845 Formula: C 23 H 33 N 1 O 4 S 1 MassAvg: 419.58 MassMono: 419.213030 Origin: C Source: natural TermSpec: none (2R)-2-amino-3-([(5Z,9Xi,12E,14Z)-1-hydroxy-1,11-oxoprosta-5,12,14-trien-9-yl]sulfanyl)propanoic acid (5Z,9Xi,12E,14Z)-9-([(2R)-2-amino-3-carboxyethyl]sulfanyl)-11-oxoprosta-5,12,14-trien-1-oic acid LIPID S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine PG-J2Cys S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycourobilin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,3R,16R)-18-ethenyl-3-[(1R)-1-([(R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydrobiline-1,19(21H,22H,24H)-dione 18-ethenyl-3-[1-(2-amino-2-carboxyethylsulfanyl)ethyl]-2,3,15,16-dihydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid BINDING Phycourobilin chromophore (covalent; via 1 link) PUB PUBCys S-phycourobilin-L-cysteine phycourobilin cysteine adduct PSI-MOD MOD:01175 S-phycourobilin-L-cysteine MOD:01175 A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycourobilin. PubMed:1903388 PubMed:3208761 PubMed:3838747 RESID:AA0427 DiffAvg: 586.69 DiffFormula: C 33 H 38 N 4 O 6 S 0 DiffMono: 586.279135 Formula: C 36 H 43 N 5 O 7 S 1 MassAvg: 689.83 MassMono: 689.288320 Origin: C Source: natural TermSpec: none (2S,3R,16R)-18-ethenyl-3-[(1R)-1-([(R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydrobiline-1,19(21H,22H,24H)-dione 18-ethenyl-3-[1-(2-amino-2-carboxyethylsulfanyl)ethyl]-2,3,15,16-dihydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid BINDING Phycourobilin chromophore (covalent; via 1 link) PUB PUBCys S-phycourobilin-L-cysteine phycourobilin cysteine adduct A protein modification that effectively cross-links an L-lysine residue and an L-lysine residue converted to allysine with a carbon-nitrogen bond to form L-dehydrolysinonorleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-([(5S)-5-amino-5-carboxypentylidene]amino)hexanoic acid 6-(N6-L-didehydrolysino)-L-norleucine CROSSLNK Dehydrolysinonorleucine (Lys-Lys) L-dehydrolysinonorleucine N6-[(5S)-5-amino-5-carboxypentylidene]-L-lysine XLNK6NleN6Lys dehydrolysinorleucine [misspelling] dehydrolysylnorleucine didehydrolysinonorleucine PSI-MOD MOD:01176 Cross-link 2. L-dehydrolysinonorleucine MOD:01176 A protein modification that effectively cross-links an L-lysine residue and an L-lysine residue converted to allysine with a carbon-nitrogen bond to form L-dehydrolysinonorleucine. PubMed:16929109 RESID:AA0430 DiffAvg: -19.05 DiffFormula: C 0 H -5 N -1 O 0 DiffMono: -19.042199 Formula: C 12 H 19 N 3 O 2 MassAvg: 237.30 MassMono: 237.147727 Origin: K, K Source: natural TermSpec: none (2S)-2-amino-6-([(5S)-5-amino-5-carboxypentylidene]amino)hexanoic acid 6-(N6-L-didehydrolysino)-L-norleucine CROSSLNK Dehydrolysinonorleucine (Lys-Lys) L-dehydrolysinonorleucine N6-[(5S)-5-amino-5-carboxypentylidene]-L-lysine XLNK6NleN6Lys dehydrolysinorleucine [misspelling] dehydrolysylnorleucine didehydrolysinonorleucine A protein modification that effectively converts an L-histidine residue to 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0416 (S)-2-amino-3-[1-(1,2,3-trihydroxypropan-2-yl)-1H-imidazol-4-yl]propanoic acid 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine 1-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]-L-histidine MOD_RES Tele-(1,2,3-trihydroxypropan-2-yl)histidine N(epsilon)-histidine dihydroxyacetone adduct N(tau)-(1,2,3-trihydroxypropan-2-yl)histidine NtauDHAHis tele-(1,2,3-trihydroxypropan-2-yl)histidine PSI-MOD MOD:01177 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine MOD:01177 A protein modification that effectively converts an L-histidine residue to 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine. PubMed:16760471 RESID:AA0431 DiffAvg: 90.08 DiffFormula: C 3 H 6 N 0 O 3 DiffMono: 90.031694 Formula: C 9 H 13 N 3 O 4 MassAvg: 227.22 MassMono: 227.090606 Origin: H Source: natural TermSpec: none (S)-2-amino-3-[1-(1,2,3-trihydroxypropan-2-yl)-1H-imidazol-4-yl]propanoic acid 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine 1-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]-L-histidine MOD_RES Tele-(1,2,3-trihydroxypropan-2-yl)histidine N(epsilon)-histidine dihydroxyacetone adduct N(tau)-(1,2,3-trihydroxypropan-2-yl)histidine NtauDHAHis tele-(1,2,3-trihydroxypropan-2-yl)histidine A protein modification that effectively converts an L-aspartic acid residue to S-(aspart-4-yloxy) thiocarbonate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-(carboxysulfanyl)oxy-4-oxobutanoic acid 4-aspartyloxysulfanylcarbonate AspOSCO2H O-carboxysulfanyl-4-oxo-L-homoserine S-(aspart-4-yloxy) thiocarbonate PSI-MOD MOD:01178 This modification was originally observed in an Entamoeba histolytica enzyme expressed in Escherichia coli. It was not chemically confirmed or characterized. It did not appear in a later model at higher resolution by the same group. This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. S-(aspart-4-yloxy) thiocarbonate MOD:01178 A protein modification that effectively converts an L-aspartic acid residue to S-(aspart-4-yloxy) thiocarbonate. PubMed:16627948 RESID:AA0432 DiffAvg: 76.07 DiffFormula: C 1 H 0 N 0 O 2 S 1 DiffMono: 75.961900 Formula: C 5 H 5 N 1 O 5 S 1 MassAvg: 191.16 MassMono: 190.988843 Origin: D Source: hypothetical TermSpec: none (2S)-2-amino-4-(carboxysulfanyl)oxy-4-oxobutanoic acid 4-aspartyloxysulfanylcarbonate AspOSCO2H O-carboxysulfanyl-4-oxo-L-homoserine S-(aspart-4-yloxy) thiocarbonate A protein modification that effectively converts an L-alanine residue to N,N-dimethyl-L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0178 (S)-1-carboxy-N,N-dimethylaminoethane (S)-2-(dimethylamino)propanoic acid MOD_RES N,N-dimethylalanine N,N-dimethyl-L-alanine N,N-dimethylalanine NMe2Ala PSI-MOD MOD:01179 N,N-dimethyl-L-alanine MOD:01179 A protein modification that effectively converts an L-alanine residue to N,N-dimethyl-L-alanine. PubMed:17691833 PubMed:387091 RESID:AA0433 DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 5 H 10 N 1 O 1 MassAvg: 100.14 MassMono: 100.076239 Origin: A Source: natural TermSpec: N-term (S)-1-carboxy-N,N-dimethylaminoethane (S)-2-(dimethylamino)propanoic acid MOD_RES N,N-dimethylalanine N,N-dimethyl-L-alanine N,N-dimethylalanine NMe2Ala A protein modification that effectively converts a glycine residue to 2-hydroxyglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-hydroxyglycine 2HyGly alpha-hydroxyglycine amino(hydroxy)acetic acid aminohydroxyacetic acid PSI-MOD MOD:01180 CAUTION - peptides of 2-hydroxyglycine are known to be unstable, decaying to break the peptide backbone or to form peptidyl amides [see J. Am. Chem. Soc. 111, 1933-1934, 1989, and J. Org. Chem. 57, 3916-3921, 1992]. If computer analysis of tandem mass-spectrometric results predicts this modification, then it is most probable that there are multiple isobaric peptides differing in the location of multiple hydroxylation modifications [JSG]. 2-hydroxyglycine observational artifact MOD:01180 A protein modification that effectively converts a glycine residue to 2-hydroxyglycine. ChEBI:38048 PubMed:16178056 PubMed:17431180 PubMed:17823333 RESID:AA0434 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 2 H 3 N 1 O 2 MassAvg: 73.05 MassMono: 73.016378 Origin: G Source: artifact TermSpec: none 2-hydroxyglycine 2HyGly alpha-hydroxyglycine amino(hydroxy)acetic acid aminohydroxyacetic acid A protein modification that effectively converts an L-aspartic acid residue to L-aspartate 4-methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-4-methoxy-4-oxobutanoic acid 2-aminobutanedioic acid 4-methyl ester 4-methyl L-2-aminosuccinic acid 4-methyl L-aspartate 4-methyl L-hydrogen aspartate L-aspartic acid 4-methyl ester O4MeAsp aspartic acid 4-methyl ester aspartic acid beta-methyl ester meesterd PSI-MOD Methyl MOD:01181 CAUTION - observations of this modifation are attributable to artifacts produced in preparation. It is extremely unlikely that eukaryotes produce this modification, because an enzyme acting to form the methyl ester of L-aspartyl peptides would interfere with the D-aspartyl peptide repair mechanism [JSG]. L-aspartic acid 4-methyl ester MOD:01181 A protein modification that effectively converts an L-aspartic acid residue to L-aspartate 4-methyl ester. OMSSA:69 PubMed:1556110 PubMed:16888766 PubMed:9629898 RESID:AA0435 Unimod:34#D DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: D Source: artifact TermSpec: none Unimod: Unimod:34 (2S)-2-amino-4-methoxy-4-oxobutanoic acid 2-aminobutanedioic acid 4-methyl ester 4-methyl L-2-aminosuccinic acid 4-methyl L-aspartate 4-methyl L-hydrogen aspartate L-aspartic acid 4-methyl ester O4MeAsp aspartic acid 4-methyl ester aspartic acid beta-methyl ester meesterd Methyl A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0681 6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine 6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FAD 6-(S-cysteinyl)-8alpha-(N(delta1)-histidyl)-FAD 6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FAD 6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FAD 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD BINDING FAD (covalent; via 2 links) BINDING FAD (covalent; via 2 links, pros nitrogen) CROSSLNK 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD (His-Cys) SCys6-NprosHis8a-FAD PSI-MOD MOD:01182 Cross-link 2. 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD MOD:01182 A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD. PubMed: RESID:AA0436 DiffAvg: 781.52 DiffFormula: C 27 H 29 N 9 O 15 P 2 S 0 DiffMono: 781.125835 Formula: C 36 H 41 N 13 O 17 P 2 S 1 MassAvg: 1021.81 MassMono: 1021.193931 Origin: C, H Source: natural TermSpec: none 6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine 6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FAD 6-(S-cysteinyl)-8alpha-(N(delta1)-histidyl)-FAD 6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FAD 6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FAD 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD BINDING FAD (covalent; via 2 links) BINDING FAD (covalent; via 2 links, pros nitrogen) CROSSLNK 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD (His-Cys) SCys6-NprosHis8a-FAD A protein modification that effectively cross-links two L-selenocysteine residues to form L-selenocystine, DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid) 3,3'-diselenobis(2-aminopropanoic acid) 3,3'-diselenobisalanine 3,3'-diselenodialanine CROSSLNK Selenocystine (Sec-Sec) L-selenocystine Sec2 beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide beta,beta'-diselenodialanine bis(alpha-aminopropionic acid)-beta-diselenide bis(beta-amino-beta-carboxyethyl)diselenide diselenocysteine selenium cystine PSI-MOD MOD:01183 Cross-link 2; for formation of the same modification by substitution of 2 selenium for 2 sulfur atoms in L-cystine, see MOD:01184. L-selenocystine (oxidized selenocysteine) (Sec-Sec) MOD:01183 A protein modification that effectively cross-links two L-selenocysteine residues to form L-selenocystine, ChEBI:28553 PubMed:17715293 PubMed:6076213 RESID:AA0437 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 Se 0 DiffMono: -2.015650 Formula: C 6 H 8 N 2 O 2 Se 2 MassAvg: 298.08 MassMono: 299.891620 Origin: U, U Source: hypothetical TermSpec: none (R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid) 3,3'-diselenobis(2-aminopropanoic acid) 3,3'-diselenobisalanine 3,3'-diselenodialanine CROSSLNK Selenocystine (Sec-Sec) L-selenocystine Sec2 beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide beta,beta'-diselenodialanine bis(alpha-aminopropionic acid)-beta-diselenide bis(beta-amino-beta-carboxyethyl)diselenide diselenocysteine selenium cystine A protein modification that effectively substitutes two selenium atoms for two sulfur atoms in L-cystine to form L-selenocystine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid) 3,3'-diselenobis(2-aminopropanoic acid) 3,3'-diselenobisalanine 3,3'-diselenodialanine CROSSLNK Selenocystine (Sec-Sec) L-selenocystine Se2(S2)Cys2 beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide beta,beta'-diselenodialanine bis(alpha-aminopropionic acid)-beta-diselenide bis(beta-amino-beta-carboxyethyl)diselenide diselenocysteine selenium cystine PSI-MOD MOD:01184 Cross-link 2; for formation of the same modification by oxidation of two L-selenocysteine residues, see MOD:01183. L-selenocystine (selenium disubstituted L-cystine) MOD:01184 A protein modification that effectively substitutes two selenium atoms for two sulfur atoms in L-cystine to form L-selenocystine. PubMed:17715293 RESID:AA0437#CYS2 DiffAvg: 91.81 DiffFormula: C 0 H -2 N 0 O 0 S -2 Se 2 DiffMono: 93.873250 Formula: C 6 H 8 N 2 O 2 Se 2 MassAvg: 298.08 MassMono: 299.891620 Origin: C, C Source: hypothetical TermSpec: none (R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid) 3,3'-diselenobis(2-aminopropanoic acid) 3,3'-diselenobisalanine 3,3'-diselenodialanine CROSSLNK Selenocystine (Sec-Sec) L-selenocystine Se2(S2)Cys2 beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide beta,beta'-diselenodialanine bis(alpha-aminopropionic acid)-beta-diselenide bis(beta-amino-beta-carboxyethyl)diselenide diselenocysteine selenium cystine A protein modification that effectively converts an L-aspartic acid residue to L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-butanediamic acid 2,4-bis(azanyl)-4-oxobutanoic acid 2,4-diamino-4-oxobutanoic acid 2-amino-3-carbamoylpropanoic acid 2-amino-4-butanediamic acid 2-aminosuccinamic acid 2-aminosuccinic acid 4-amide 4NAsp L-asparagine MOD_RES Amidated aspartic acid alpha-amino-beta-carbamylpropionic acid alpha-aminosuccinamic acid aspartic acid 4-amide aspartic acid beta-amide beta-asparagine PSI-MOD MOD:01185 4-amidated L-aspartic acid MOD:01185 A protein modification that effectively converts an L-aspartic acid residue to L-asparagine. PubMed:17962566 RESID:AA0003#ASP DiffAvg: -0.98 DiffFormula: C 0 H 1 N 1 O -1 DiffMono: -0.984016 Formula: C 4 H 6 N 2 O 2 MassAvg: 114.10 MassMono: 114.042927 Origin: D Source: natural TermSpec: none (2S)-2-amino-4-butanediamic acid 2,4-bis(azanyl)-4-oxobutanoic acid 2,4-diamino-4-oxobutanoic acid 2-amino-3-carbamoylpropanoic acid 2-amino-4-butanediamic acid 2-aminosuccinamic acid 2-aminosuccinic acid 4-amide 4NAsp L-asparagine MOD_RES Amidated aspartic acid alpha-amino-beta-carbamylpropionic acid alpha-aminosuccinamic acid aspartic acid 4-amide aspartic acid beta-amide beta-asparagine A protein modification that effectively converts an L-threonine residue to either N-acetyl-L-threonne, or O-acetyl-Lthreonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: AcThr PSI-MOD MOD:01186 monoacetylated L-threonine MOD:01186 A protein modification that effectively converts an L-threonine residue to either N-acetyl-L-threonne, or O-acetyl-Lthreonine. PubMed:18688235 DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: none MassAvg: none MassMono: none Origin: T Source: natural AcThr A protein modification that inserts or replaces a residue with an L-pyrrolysine residue, a natural pretranslational modification. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid 2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid L-pyrrolysine N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine NON_STD Pyrrolysine Pyl monomethylamine methyltransferase cofactor lysine adduct PSI-MOD MOD:01187 L-pyrrolysine residue MOD:01187 A protein modification that inserts or replaces a residue with an L-pyrrolysine residue, a natural pretranslational modification. ChEBI:21860 PubMed:11435424 PubMed:12029131 PubMed:12029132 PubMed:15314242 PubMed:16096277 RESID:AA0321 Unimod:435 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 12 H 19 N 3 O 2 MassAvg: 237.30 MassMono: 237.147727 Origin: O Source: natural TermSpec: none Unimod: Unimod:435 (2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid 2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid L-pyrrolysine N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine NON_STD Pyrrolysine Pyl monomethylamine methyltransferase cofactor lysine adduct modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD N-ethyl iodoacetamide-d5 NEIAA:2H(5) MOD:01188 N-ethyl iodoacetamide-d5 - site Y MOD:01188 modification from Unimod Isotopic label - PubMed:11710128 PubMed:12766232 PubMed:3155470 PubMed:957432 Unimod:212#Y DiffAvg: 90.08 DiffFormula: C 4 (1)H 2 (2)H 5 N 1 O 1 DiffMono: 90.084148 Formula: C 13 (1)H 11 (2)H 5 N 2 O 3 MassAvg: 253.15 MassMono: 253.147476 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:212 N-ethyl iodoacetamide-d5 NEIAA:2H(5) modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD N-ethyl iodoacetamide-d5 NEIAA:2H(5) MOD:01189 N-ethyl iodoacetamide-d5 - site C MOD:01189 modification from Unimod Isotopic label - PubMed:12766232 Unimod:212#C DiffAvg: 90.08 DiffFormula: C 4 (1)H 2 (2)H 5 N 1 O 1 DiffMono: 90.084148 Formula: C 7 (1)H 7 (2)H 5 N 2 O 2 S 1 MassAvg: 193.09 MassMono: 193.093332 Origin: C Source: artifact TermSpec: none Unimod: Unimod:212 N-ethyl iodoacetamide-d5 NEIAA:2H(5) Modification from Unimod Chemical derivative. OBSOLETE because duplicate and redundant with MOD:01006. Remap to MOD:01006. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Dibromo MOD:01190 dibromo true MOD:01190 Modification from Unimod Chemical derivative. OBSOLETE because duplicate and redundant with MOD:01006. Remap to MOD:01006. Unimod:534 DiffAvg: 157.79 DiffFormula: Br 2 H -2 DiffMono: 155.821024 Formula: none MassAvg: none MassMono: none Origin: Y Remap: MOD:01006 Source: none TermSpec: none Unimod: Unimod:534 Dibromo Dibromo modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD N-ethyl iodoacetamide-d0 NEIAA MOD:01191 N-ethyl iodoacetamide-d0 - site C MOD:01191 modification from Unimod Isotopic label - PubMed:12766232 Unimod:211#C DiffAvg: 85.11 DiffFormula: C 4 H 7 N 1 O 1 DiffMono: 85.052764 Formula: C 7 H 12 N 2 O 2 S 1 MassAvg: 188.25 MassMono: 188.061949 Origin: C Source: artifact TermSpec: none Unimod: Unimod:211 N-ethyl iodoacetamide-d0 NEIAA modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD N-ethyl iodoacetamide-d0 NEIAA MOD:01192 N-ethyl iodoacetamide-d0 - site Y MOD:01192 modification from Unimod Isotopic label - PubMed:11760118 PubMed:12766232 Unimod:211#Y DiffAvg: 85.11 DiffFormula: C 4 H 7 N 1 O 1 DiffMono: 85.052764 Formula: C 13 H 16 N 2 O 3 MassAvg: 248.28 MassMono: 248.116092 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:211 N-ethyl iodoacetamide-d0 NEIAA modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD PET phosphorylation to pyridyl thiol MOD:01193 pyridyl thiol modified L-threonine MOD:01193 modification from Unimod Chemical derivative - PubMed:1093385 Unimod:264#T DiffAvg: 121.20 DiffFormula: C 7 H 7 N 1 O -1 S 1 DiffMono: 121.035006 Formula: C 11 H 14 N 2 O 1 S 1 MassAvg: 222.31 MassMono: 222.082684 Origin: T Source: artifact TermSpec: none Unimod: Unimod:264 PET phosphorylation to pyridyl thiol modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD PET phosphorylation to pyridyl thiol MOD:01194 pyridyl thiol modified L-serine MOD:01194 modification from Unimod Chemical derivative - PubMed:15279557 Unimod:264#S DiffAvg: 121.20 DiffFormula: C 7 H 7 N 1 O -1 S 1 DiffMono: 121.035006 Formula: C 10 H 12 N 2 O 1 S 1 MassAvg: 208.28 MassMono: 208.067034 Origin: S Source: artifact TermSpec: none Unimod: Unimod:264 PET phosphorylation to pyridyl thiol modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Benzoyl labeling reagent light form (N-term & K) MOD:01195 benzoyl labeling reagent light form - site K MOD:01195 modification from Unimod Isotopic label - PubMed:11813307 PubMed:12777388 PubMed:15456300 Unimod:136#K DiffAvg: 104.11 DiffFormula: C 7 H 4 O 1 DiffMono: 104.026215 Formula: C 13 H 16 N 2 O 2 MassAvg: 232.28 MassMono: 232.121178 Origin: K Source: artifact TermSpec: none Unimod: Unimod:136 Benzoyl labeling reagent light form (N-term & K) OBSOLETE because redundant, replaced with MOD:01654. Remap to MOD:01654. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD 5-dimethylaminonaphthalene-1-sulfonyl Dansyl MOD:01196 5-dimethylaminonaphthalene-1-sulfonyl - site K true MOD:01196 OBSOLETE because redundant, replaced with MOD:01654. Remap to MOD:01654. Unimod:139 DiffAvg: 233.29 DiffFormula: C 12 H 11 N 1 O 2 S 1 DiffMono: 233.051050 Formula: C 18 H 23 N 3 O 3 S 1 MassAvg: 361.46 MassMono: 361.146013 Origin: K Remap: MOD:01654 Source: artifact TermSpec: none Unimod: Unimod:139 5-dimethylaminonaphthalene-1-sulfonyl Dansyl A protein modification that effectively converts an L-glutamine residue to N-heptosyl-L-glutamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hep Heptose MOD:01197 From Unimod with no citation [JSG]. N-heptosyl-L-glutamine MOD:01197 A protein modification that effectively converts an L-glutamine residue to N-heptosyl-L-glutamine. Unimod:490#Q DiffAvg: 192.17 DiffFormula: C 7 H 12 O 6 DiffMono: 192.063388 Formula: C 12 H 20 N 2 O 8 MassAvg: 320.30 MassMono: 320.121966 Origin: Q Source: artifact TermSpec: none Unimod: Unimod:490 Hep Heptose A protein modification that effectively converts an L-serine residue to O-heptosyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hep Heptose MOD:01198 From Unimod with no citation [JSG]. O-heptosyl-L-serine MOD:01198 A protein modification that effectively converts an L-serine residue to O-heptosyl-L-serine. Unimod:490#S DiffAvg: 192.17 DiffFormula: C 7 H 12 O 6 DiffMono: 192.063388 Formula: C 10 H 17 N 1 O 8 MassAvg: 279.25 MassMono: 279.095417 Origin: S Source: artifact TermSpec: none Unimod: Unimod:490 Hep Heptose A protein modification that effectively converts an L-arginine residue to an N-heptosyl-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hep Heptose MOD:01199 From Unimod with no citation [JSG]. N-heptosyl-L-arginine MOD:01199 A protein modification that effectively converts an L-arginine residue to an N-heptosyl-L-arginine. Unimod:490#R DiffAvg: 192.17 DiffFormula: C 7 H 12 O 6 DiffMono: 192.063388 Formula: C 13 H 24 N 4 O 7 MassAvg: 348.36 MassMono: 348.164499 Origin: R Source: artifact TermSpec: none Unimod: Unimod:490 Hep Heptose A protein modification that effectively converts an L-threonine residue to O-heptosyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hep Heptose MOD:01200 From Unimod with no citation [JSG]. O-heptosyl-L-threonine MOD:01200 A protein modification that effectively converts an L-threonine residue to O-heptosyl-L-threonine. Unimod:490#T DiffAvg: 192.17 DiffFormula: C 7 H 12 O 6 DiffMono: 192.063388 Formula: C 11 H 19 N 1 O 8 MassAvg: 293.27 MassMono: 293.111067 Origin: T Source: artifact TermSpec: none Unimod: Unimod:490 Hep Heptose A protein modification that effectively converts an L-lysine residue to N6-heptosyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hep Heptose MOD:01201 From Unimod with no citation [JSG]. N6-heptosyl-L-lysine MOD:01201 A protein modification that effectively converts an L-lysine residue to N6-heptosyl-L-lysine. Unimod:490#K DiffAvg: 192.17 DiffFormula: C 7 H 12 O 6 DiffMono: 192.063388 Formula: C 13 H 24 N 2 O 7 MassAvg: 320.34 MassMono: 320.158351 Origin: K Source: artifact TermSpec: none Unimod: Unimod:490 Hep Heptose A protein modification that effectively converts an L-asparagine residue to N-heptosyl-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hep Heptose MOD:01202 From Unimod with no citation [JSG]. N-heptosyl-L-asparagine MOD:01202 A protein modification that effectively converts an L-asparagine residue to N-heptosyl-L-asparagine. Unimod:490#N DiffAvg: 192.17 DiffFormula: C 7 H 12 O 6 DiffMono: 192.063388 Formula: C 11 H 18 N 2 O 8 MassAvg: 306.27 MassMono: 306.106316 Origin: N Source: artifact TermSpec: none Unimod: Unimod:490 Hep Heptose A protein modification that effectively converts an L-lysine residue to N6-[(pyrid-3-yl)acetyl]lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Pyridylacetyl pyridylacetyl MOD:01203 Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. N6-(pyridylacetyl)lysine MOD:01203 A protein modification that effectively converts an L-lysine residue to N6-[(pyrid-3-yl)acetyl]lysine. PubMed:9276974 Unimod:25#K DiffAvg: 119.12 DiffFormula: C 7 H 5 N 1 O 1 DiffMono: 119.037114 Formula: C 13 H 17 N 3 O 2 MassAvg: 247.30 MassMono: 247.132077 Origin: K Source: artifact TermSpec: none Unimod: Unimod:25 Pyridylacetyl pyridylacetyl modification from Unimod Artifact - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Dethiomethyl Prompt loss of side chain from oxidised Met MOD:01204 prompt loss of methanethiol from oxidixed methionine MOD:01204 modification from Unimod Artifact - PubMed:9004526 Unimod:526 DiffAvg: -48.10 DiffFormula: C -1 H -4 S -1 DiffMono: -48.003371 Formula: C 4 H 5 N 1 O 1 S 0 MassAvg: 83.09 MassMono: 83.037114 Origin: M Source: artifact TermSpec: none Unimod: Unimod:526 Dethiomethyl Prompt loss of side chain from oxidised Met A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(1)NeuAc(2) Hex1HexNAc1NeuAc2 MOD:01205 Hex1HexNAc1NeuAc2 O-glycosylated serine MOD:01205 A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. PubMed:7949339 Unimod:160#S DiffAvg: 947.85 DiffFormula: C 36 H 57 N 3 O 26 DiffMono: 947.323029 Formula: C 39 H 62 N 4 O 28 MassAvg: 1034.93 MassMono: 1034.355057 Origin: S Source: natural TermSpec: none Unimod: Unimod:160 Hex(1)HexNAc(1)NeuAc(2) Hex1HexNAc1NeuAc2 A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(1)NeuAc(2) Hex1HexNAc1NeuAc2 MOD:01206 Hex1HexNAc1NeuAc2 O-glycosylated threonine MOD:01206 A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. Unimod:160#T DiffAvg: 947.85 DiffFormula: C 36 H 57 N 3 O 26 DiffMono: 947.323029 Formula: C 40 H 64 N 4 O 28 MassAvg: 1048.95 MassMono: 1048.370707 Origin: T Source: natural TermSpec: none Unimod: Unimod:160 Hex(1)HexNAc(1)NeuAc(2) Hex1HexNAc1NeuAc2 A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(1)NeuAc(2) Hex1HexNAc1NeuAc2 MOD:01207 Hex1HexNAc1NeuAc2 N4-glycosylated asparagine MOD:01207 A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond. Unimod:160#N DiffAvg: 947.85 DiffFormula: C 36 H 57 N 3 O 26 DiffMono: 947.323029 Formula: C 40 H 63 N 5 O 28 MassAvg: 1061.95 MassMono: 1061.365956 Origin: N Source: natural TermSpec: none Unimod: Unimod:160 Hex(1)HexNAc(1)NeuAc(2) Hex1HexNAc1NeuAc2 A protein modification that effectively converts a C-terminal residue to the copper(1+) carboxylate salt. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: cuprous salt PSI-MOD Cation:Cu[I] Replacement of proton by copper MOD:01208 copper(1+) carboxylate C-terminal residue MOD:01208 A protein modification that effectively converts a C-terminal residue to the copper(1+) carboxylate salt. Unimod:531#C-term DiffAvg: 62.54 DiffFormula: Cu 1 H -1 DiffMono: 61.921772 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: C-term Unimod: Unimod:531 cuprous salt Cation:Cu[I] Replacement of proton by copper A protein modification that effectively converts an L-aspartic acid residue to the copper(1+) aspartate salt. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: cuprous salt PSI-MOD Cation:Cu[I] Replacement of proton by copper MOD:01209 copper(1+) L-aspartate MOD:01209 A protein modification that effectively converts an L-aspartic acid residue to the copper(1+) aspartate salt. Unimod:531#D DiffAvg: 62.54 DiffFormula: Cu 1 H -1 DiffMono: 61.921772 Formula: C 4 Cu 1 H 4 N 1 O 3 MassAvg: 177.63 MassMono: 176.948715 Origin: D Source: none TermSpec: none Unimod: Unimod:531 cuprous salt Cation:Cu[I] Replacement of proton by copper A protein modification that effectively converts an L-glutamic acid residue to the copper(1+) glutamate salt. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: cuprous salt PSI-MOD Cation:Cu[I] Replacement of proton by copper MOD:01210 copper(1+) L-glutamate MOD:01210 A protein modification that effectively converts an L-glutamic acid residue to the copper(1+) glutamate salt. Unimod:531#E DiffAvg: 62.54 DiffFormula: Cu 1 H -1 DiffMono: 61.921772 Formula: C 5 Cu 1 H 6 N 1 O 3 MassAvg: 191.65 MassMono: 190.964366 Origin: E Source: none TermSpec: none Unimod: Unimod:531 cuprous salt Cation:Cu[I] Replacement of proton by copper A protein modification that effectively converts an L-lysine residue to N6-(morpholine-2-acetyl)-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N-succinimidylmorpholine-2-acetate N6-derivatized lysine PSI-MOD N-Succinimidyl-2-morpholine acetate SMA MOD:01211 The Unimod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. N6-(morpholine-2-acetyl)-lysine MOD:01211 A protein modification that effectively converts an L-lysine residue to N6-(morpholine-2-acetyl)-lysine. PubMed:10446193 Unimod:29#K DiffAvg: 127.14 DiffFormula: C 6 H 9 N 1 O 2 DiffMono: 127.063329 Formula: C 12 H 21 N 3 O 3 MassAvg: 255.32 MassMono: 255.158292 Origin: K Source: artifact TermSpec: none Unimod: Unimod:29 N-succinimidylmorpholine-2-acetate N6-derivatized lysine N-Succinimidyl-2-morpholine acetate SMA A protein modification that effectively converts an L-lysine residue to N6-(carboxamidomethyl)lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N6-(2-amino-2-oxoethyl)lysine N6-(carbamoylmethyl)lysine carbamidomethylk PSI-MOD Carbamidomethyl Iodoacetamide derivative MOD:01212 iodoacetamide N6-derivatized lysine MOD:01212 A protein modification that effectively converts an L-lysine residue to N6-(carboxamidomethyl)lysine. OMSSA:27 PubMed:11510821 PubMed:12422359 PubMed:12686488 Unimod:4#K DiffAvg: 57.05 DiffFormula: C 2 H 3 N 1 O 1 DiffMono: 57.021464 Formula: C 8 H 15 N 3 O 2 MassAvg: 185.23 MassMono: 185.116427 Origin: K Source: artifact TermSpec: none Unimod: Unimod:4 N6-(2-amino-2-oxoethyl)lysine N6-(carbamoylmethyl)lysine carbamidomethylk Carbamidomethyl Iodoacetamide derivative A protein modification that effectively converts an L-histidine residue to an iodoacetamide derivatized histidine, either 1'- or 3'-(carboxamidolmethyl)histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: carbamidometylh PSI-MOD Carbamidomethyl Iodoacetamide derivative MOD:01213 iodoacetamide derivatized histidine MOD:01213 A protein modification that effectively converts an L-histidine residue to an iodoacetamide derivatized histidine, either 1'- or 3'-(carboxamidolmethyl)histidine. OMSSA:28 PubMed:11510821 PubMed:12422359 PubMed:15627961 PubMed:2026710 Unimod:4#H DiffAvg: 57.05 DiffFormula: C 2 H 3 N 1 O 1 DiffMono: 57.021464 Formula: C 8 H 10 N 4 O 2 MassAvg: 194.19 MassMono: 194.080376 Origin: H Source: artifact TermSpec: none Unimod: Unimod:4 carbamidometylh Carbamidomethyl Iodoacetamide derivative modification from Unimod Chemical derivative - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Carbamidomethyl Iodoacetamide derivative MOD:01214 iodoacetamide - site C true MOD:01214 modification from Unimod Chemical derivative - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060. PubMed:10504701 PubMed:11510821 PubMed:12422359 Unimod:4#C DiffAvg: 57.05 DiffFormula: C 2 H 3 N 1 O 1 DiffMono: 57.021464 Formula: none MassAvg: none MassMono: none Origin: C Remap: MOD:01060 Source: artifact TermSpec: none Unimod: Unimod:4 Carbamidomethyl Iodoacetamide derivative A protein modification that effectively converts an L-aspartic acid residue to O4-(carboxamidomethyl)aspartate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: carbamidomethyld PSI-MOD Carbamidomethyl Iodoacetamide derivative MOD:01215 iodoacetamide derivatized aspartic acid MOD:01215 A protein modification that effectively converts an L-aspartic acid residue to O4-(carboxamidomethyl)aspartate. OMSSA:29 PubMed:11510821 PubMed:12422359 PubMed:16526082 Unimod:4#D DiffAvg: 57.05 DiffFormula: C 2 H 3 N 1 O 1 DiffMono: 57.021464 Formula: C 6 H 8 N 2 O 4 MassAvg: 172.14 MassMono: 172.048407 Origin: D Source: artifact TermSpec: none Unimod: Unimod:4 carbamidomethyld Carbamidomethyl Iodoacetamide derivative A protein modification that effectively converts an L-glutamic acid residue to O5-(carboxamidomethyl)glutamate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: carbamidomethyle PSI-MOD Carbamidomethyl Iodoacetamide derivative MOD:01216 iodoacetamide derivatized glutamic acid MOD:01216 A protein modification that effectively converts an L-glutamic acid residue to O5-(carboxamidomethyl)glutamate. OMSSA:30 PubMed:11510821 PubMed:12422359 Unimod:4#E DiffAvg: 57.05 DiffFormula: C 2 H 3 N 1 O 1 DiffMono: 57.021464 Formula: C 7 H 10 N 2 O 4 MassAvg: 186.17 MassMono: 186.064057 Origin: E Source: artifact TermSpec: none Unimod: Unimod:4 carbamidomethyle Carbamidomethyl Iodoacetamide derivative modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Light Sulfanilic Acid (SA) C12 SulfanilicAcid MOD:01217 Sulfanilic Acid (SA), light C12 - site D MOD:01217 modification from Unimod Isotopic label - PubMed:12872131 Unimod:285#D DiffAvg: 155.00 DiffFormula: (12)C 6 H 5 N 1 O 2 S 1 DiffMono: 155.004099 Formula: (12)C 10 H 10 N 2 O 5 S 1 MassAvg: 270.03 MassMono: 270.031042 Origin: D Source: artifact TermSpec: none Unimod: Unimod:285 Light Sulfanilic Acid (SA) C12 SulfanilicAcid modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Light Sulfanilic Acid (SA) C12 SulfanilicAcid MOD:01218 Sulfanilic Acid (SA), light C12 - site E MOD:01218 modification from Unimod Isotopic label - PubMed:15283597 Unimod:285#E DiffAvg: 155.00 DiffFormula: (12)C 6 H 5 N 1 O 2 S 1 DiffMono: 155.004099 Formula: (12)C 11 H 12 N 2 O 5 S 1 MassAvg: 284.05 MassMono: 284.046692 Origin: E Source: artifact TermSpec: none Unimod: Unimod:285 Light Sulfanilic Acid (SA) C12 SulfanilicAcid modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Heavy Sulfanilic Acid (SA) C13 SulfanilicAcid:13C(6) MOD:01219 Sulfanilic Acid (SA), heavy C13 - site D MOD:01219 modification from Unimod Chemical derivative - PubMed:9254591 PubMed:9750125 Unimod:286#D DiffAvg: 161.02 DiffFormula: (13)C 6 H 5 N 1 O 2 S 1 DiffMono: 161.024228 Formula: (12)C 4 (13)C 6 H 10 N 2 O 5 S 1 MassAvg: 276.05 MassMono: 276.051171 Origin: D Source: artifact TermSpec: none Unimod: Unimod:286 Heavy Sulfanilic Acid (SA) C13 SulfanilicAcid:13C(6) modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Heavy Sulfanilic Acid (SA) C13 SulfanilicAcid:13C(6) MOD:01220 Sulfanilic Acid (SA), heavy C13 - site E MOD:01220 modification from Unimod Chemical derivative - PubMed:15121203 PubMed:9254591 Unimod:286#E DiffAvg: 161.02 DiffFormula: (13)C 6 H 5 N 1 O 2 S 1 DiffMono: 161.024228 Formula: (12)C 5 (13)C 6 H 12 N 2 O 5 S 1 MassAvg: 290.07 MassMono: 290.066822 Origin: E Source: artifact TermSpec: none Unimod: Unimod:286 Heavy Sulfanilic Acid (SA) C13 SulfanilicAcid:13C(6) A protein modification that effectively converts an L-threonine residue to O-formyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Formyl Formylation MOD:01221 From Unimod: Can occur under CNBr cleavage conditions (70% HCOOH). O-formyl-L-threonine MOD:01221 A protein modification that effectively converts an L-threonine residue to O-formyl-L-threonine. PubMed:11861642 PubMed:15799070 Unimod:122#T DiffAvg: 28.01 DiffFormula: C 1 O 1 DiffMono: 27.994915 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: T Source: artifact TermSpec: none Unimod: Unimod:122 Formyl Formylation A protein modification that effectively converts an L-serine residue to O-formyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Formyl Formylation MOD:01222 From Unimod: Can occur under CNBr cleavage conditions (70% HCOOH). O-formyl-L-serine MOD:01222 A protein modification that effectively converts an L-serine residue to O-formyl-L-serine. PubMed:15627961 PubMed:15799070 Unimod:122#S DiffAvg: 28.01 DiffFormula: C 1 O 1 DiffMono: 27.994915 Formula: C 4 H 5 N 1 O 3 MassAvg: 115.09 MassMono: 115.026943 Origin: S Source: artifact TermSpec: none Unimod: Unimod:122 Formyl Formylation modification from Unimod Other - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: ntermpeptioacetyl PSI-MOD 3,3-Dithio-bis-(sulfosuccinimidyl)propionate Thioacyl thioacylation of primary amines (N-term and Lys) MOD:01223 This Unimod entry is misdescribed as "thioacylation" [JSG]. thioacylation of primary amines - site N-term MOD:01223 modification from Unimod Other - OMSSA:41 PubMed:11710128 PubMed:3155470 PubMed:957432 Unimod:126#N-term DiffAvg: 88.12 DiffFormula: C 3 H 4 O 1 S 1 DiffMono: 87.998286 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:126 ntermpeptioacetyl 3,3-Dithio-bis-(sulfosuccinimidyl)propionate Thioacyl thioacylation of primary amines (N-term and Lys) modification from Unimod Other - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: thioacetylk PSI-MOD 3,3-Dithio-bis-(sulfosuccinimidyl)propionate Thioacyl thioacylation of primary amines (N-term and Lys) MOD:01224 This Unimod entry is misdescribed as "thioacylation" [JSG]. thioacylation of primary amines - site K MOD:01224 modification from Unimod Other - OMSSA:40 PubMed:11710128 PubMed:3155470 PubMed:957432 Unimod:126#K DiffAvg: 88.12 DiffFormula: C 3 H 4 O 1 S 1 DiffMono: 87.998286 Formula: C 9 H 16 N 2 O 2 S 1 MassAvg: 216.30 MassMono: 216.093249 Origin: K Source: artifact TermSpec: none Unimod: Unimod:126 thioacetylk 3,3-Dithio-bis-(sulfosuccinimidyl)propionate Thioacyl thioacylation of primary amines (N-term and Lys) A protein modification that effectively converts an L-tyrosine residue into an L-fluorotyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: phef PSI-MOD Fluoro fluorophenylalanine replacement of phenylalanine MOD:01225 From Unimod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. monofluorinated L-tyrosine MOD:01225 A protein modification that effectively converts an L-tyrosine residue into an L-fluorotyrosine. OMSSA:46 PubMed:8069568 Unimod:127#Y DiffAvg: 17.99 DiffFormula: F 1 H -1 DiffMono: 17.990578 Formula: C 9 F 1 H 8 N 1 O 2 MassAvg: 181.17 MassMono: 181.053907 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:127 phef Fluoro fluorophenylalanine replacement of phenylalanine A protein modification that effectively converts an L-tryptophan residue to an L-fluorotryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Fluoro fluorophenylalanine replacement of phenylalanine MOD:01226 From Unimod: the citation appears to be correct, but the PMID is not and has been corrected [JSG]. monofluorinated L-tryptophan MOD:01226 A protein modification that effectively converts an L-tryptophan residue to an L-fluorotryptophan. PubMed:8069568 Unimod:127#W DiffAvg: 17.99 DiffFormula: F 1 H -1 DiffMono: 17.990578 Formula: C 11 F 1 H 9 N 2 O 1 MassAvg: 204.20 MassMono: 204.069891 Origin: W Source: artifact TermSpec: none Unimod: Unimod:127 Fluoro fluorophenylalanine replacement of phenylalanine A protein modification that effectively converts an L-phenylalanine residue to an L-fluorophenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: phef PSI-MOD Fluoro fluorophenylalanine replacement of phenylalanine MOD:01227 From Unimod: the citation appears to be correct, but the PMID is not and has been corrected. From DeltaMass: (element abbreviation in formula incorrect, mass incorrect, and aggregate not delta) Average Mass: 149 Formula: C9H8O1N1Fl1 Average Mass Change: 149 References:PE Sciex with no citation [JSG]. monofluorinated L-phenylalanine MOD:01227 A protein modification that effectively converts an L-phenylalanine residue to an L-fluorophenylalanine. DeltaMass:181 OMSSA:46 PubMed:8069568 Unimod:127#F DiffAvg: 17.99 DiffFormula: C 0 F 1 H -1 N 0 O 0 DiffMono: 17.990578 Formula: C 9 F 1 H 8 N 1 O 1 MassAvg: 165.17 MassMono: 165.058992 Origin: F Source: artifact TermSpec: none Unimod: Unimod:127 phef Fluoro fluorophenylalanine replacement of phenylalanine A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one iodine atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: I1Tyr iodinationy PSI-MOD Iodination Iodo MOD:01228 From DeltaMass: Average Mass: 289 [name misspelled "monoiodated" - JSG]. monoiodinated tyrosine MOD:01228 A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one iodine atom. DeltaMass:0 OMSSA:65 PubMed:1326520 PubMed:15627961 PubMed:2026710 Unimod:129#Y DiffAvg: 125.90 DiffFormula: H -1 I 1 DiffMono: 125.896648 Formula: C 9 H 8 I 1 N 1 O 2 MassAvg: 289.07 MassMono: 288.959976 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:129 I1Tyr iodinationy Iodination Iodo A protein modification that effectively converts an L-histidine residue to an L-iodohistidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: I1His PSI-MOD Iodination Iodo MOD:01229 L-iodohistidine MOD:01229 A protein modification that effectively converts an L-histidine residue to an L-iodohistidine. PubMed:15627961 PubMed:2026710 Unimod:129#H DiffAvg: 125.90 DiffFormula: C 0 H -1 I 1 N 0 O 0 DiffMono: 125.896648 Formula: C 6 H 6 I 1 N 3 O 1 MassAvg: 263.04 MassMono: 262.955560 Origin: H Source: artifact TermSpec: none Unimod: Unimod:129 I1His Iodination Iodo modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form ICPL MOD:01230 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form - site K MOD:01230 modification from Unimod Isotopic label - PubMed:15602776 Unimod:365#K DiffAvg: 105.02 DiffFormula: (12)C 6 H 3 N 1 O 1 DiffMono: 105.021464 Formula: (12)C 12 H 15 N 3 O 2 MassAvg: 233.12 MassMono: 233.116427 Origin: K Source: artifact TermSpec: none Unimod: Unimod:365 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form ICPL A protein modification that effectively converts an L-lysine residue to 3x(13)C labeled N6-propanoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Propionate labeling reagent heavy form (+3amu), N-term & K Propionyl:13C(3) MOD:01231 3x(13)C labeled N6-propanoyl-L-lysine MOD:01231 A protein modification that effectively converts an L-lysine residue to 3x(13)C labeled N6-propanoyl-L-lysine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:12442261 Unimod:59#K DiffAvg: 59.04 DiffFormula: (13)C 3 H 4 O 1 DiffMono: 59.036279 Formula: (12)C 6 (13)C 3 H 16 N 2 O 2 MassAvg: 187.13 MassMono: 187.131242 Origin: K Source: artifact TermSpec: none Unimod: Unimod:59 Propionate labeling reagent heavy form (+3amu), N-term & K Propionyl:13C(3) A protein modification that effectively converts an L-lysine residue to 3x(12)C labeled N6-propanoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Propionate labeling reagent light form (N-term & K) Propionyl MOD:01232 3x(12)C labeled N6-propanoyl-L-lysine MOD:01232 A protein modification that effectively converts an L-lysine residue to 3x(12)C labeled N6-propanoyl-L-lysine. PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:58#K DiffAvg: 56.03 DiffFormula: (12)C 3 H 4 O 1 DiffMono: 56.026215 Formula: (12)C 9 H 16 N 2 O 2 MassAvg: 184.12 MassMono: 184.121178 Origin: K Source: artifact TermSpec: none Unimod: Unimod:58 Propionate labeling reagent light form (N-term & K) Propionyl A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled N6-acetyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acetate labeling reagent (N-term & K) (heavy form, +3amu) Acetyl:2H(3) MOD:01233 3x(2)H labeled N6-acetyl-L-lysine MOD:01233 A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled N6-acetyl-L-lysine. PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:56#K DiffAvg: 45.03 DiffFormula: C 2 (1)H -1 (2)H 3 O 1 DiffMono: 45.029395 Formula: C 8 (1)H 11 (2)H 3 N 2 O 2 MassAvg: 173.12 MassMono: 173.124358 Origin: K Source: artifact TermSpec: none Unimod: Unimod:56 Acetate labeling reagent (N-term & K) (heavy form, +3amu) Acetyl:2H(3) modification from Unimod Isotopic label - alkaline phosphatase to dephosphorylate DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Label:18O(1) O18 Labeling MOD:01234 (18)O monosubstituted L-serine MOD:01234 modification from Unimod Isotopic label - alkaline phosphatase to dephosphorylate PubMed:11467524 Unimod:258#S DiffAvg: 2.00 DiffFormula: (16)O -1 (18)O 1 DiffMono: 2.004246 Formula: C 3 H 5 N 1 (16)O 1 (18)O 1 MassAvg: 89.04 MassMono: 89.036275 Origin: S Source: artifact TermSpec: none Unimod: Unimod:258 Label:18O(1) O18 Labeling modification from Unimod Isotopic label - alkaline phosphatase to dephosphorylate DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Label:18O(1) O18 Labeling MOD:01235 (18)O monosubstituted L-threonine MOD:01235 modification from Unimod Isotopic label - alkaline phosphatase to dephosphorylate PubMed:11467524 PubMed:15549660 Unimod:258#T DiffAvg: 2.00 DiffFormula: (16)O -1 (18)O 1 DiffMono: 2.004246 Formula: C 4 H 7 N 1 (16)O 1 (18)O 1 MassAvg: 103.05 MassMono: 103.051925 Origin: T Source: artifact TermSpec: none Unimod: Unimod:258 Label:18O(1) O18 Labeling modification from Unimod Isotopic label - alkaline phosphatase to dephosphorylate DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Label:18O(1) O18 Labeling MOD:01236 (18)O monosubstituted L-tyrosine MOD:01236 modification from Unimod Isotopic label - alkaline phosphatase to dephosphorylate PubMed:11467524 PubMed:15549660 Unimod:258#Y DiffAvg: 2.00 DiffFormula: (16)O -1 (18)O 1 DiffMono: 2.004246 Formula: C 9 H 9 N 1 (16)O 1 (18)O 1 MassAvg: 165.07 MassMono: 165.067575 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:258 Label:18O(1) O18 Labeling A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 4-hydroxynonenal (HNE) HNE MOD:01237 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. cysteine 4-hydroxynonenal adduct MOD:01237 A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal. PubMed:11327326 PubMed:15133838 PubMed:9629898 Unimod:53#C DiffAvg: 156.22 DiffFormula: C 9 H 16 O 2 DiffMono: 156.115030 Formula: C 12 H 21 N 1 O 3 S 1 MassAvg: 259.36 MassMono: 259.124215 Origin: C Source: artifact TermSpec: none Unimod: Unimod:53 4-hydroxynonenal (HNE) HNE A protein modification produced by formation of an adduct of an L-lysine residue with 4-hydroxynonenal. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 4-hydroxynonenal (HNE) HNE MOD:01238 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. lysine 4-hydroxynonenal adduct MOD:01238 A protein modification produced by formation of an adduct of an L-lysine residue with 4-hydroxynonenal. PubMed:11327326 PubMed:15133838 PubMed:9629898 Unimod:53#K DiffAvg: 156.22 DiffFormula: C 9 H 16 O 2 DiffMono: 156.115030 Formula: C 15 H 28 N 2 O 3 MassAvg: 284.40 MassMono: 284.209993 Origin: K Source: artifact TermSpec: none Unimod: Unimod:53 4-hydroxynonenal (HNE) HNE A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 4-hydroxynonenal (HNE) HNE MOD:01239 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. histidine 4-hydroxynonenal adduct MOD:01239 A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal. PubMed:10717661 PubMed:11327326 PubMed:15133838 Unimod:53#H DiffAvg: 156.22 DiffFormula: C 9 H 16 O 2 DiffMono: 156.115030 Formula: C 15 H 23 N 3 O 3 MassAvg: 293.37 MassMono: 293.173942 Origin: H Source: artifact TermSpec: none Unimod: Unimod:53 4-hydroxynonenal (HNE) HNE A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of leucyl-arginyl-glycyl-glycine, the C-terminal tetrapeptide of ubiquitin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD LeuArgGlyGly Ubiquitination MOD:01240 ubiquitination signature tetrapeptidyl lysine MOD:01240 A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of leucyl-arginyl-glycyl-glycine, the C-terminal tetrapeptide of ubiquitin. PubMed:10504701 Unimod:535 DiffAvg: 383.45 DiffFormula: C 16 H 29 N 7 O 4 DiffMono: 383.228102 Formula: C 22 H 41 N 9 O 5 MassAvg: 511.63 MassMono: 511.323065 Origin: K Source: artifact TermSpec: none Unimod: Unimod:535 LeuArgGlyGly Ubiquitination A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-aspartic acid 4-methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: trideuteromethyld PSI-MOD Methyl:2H(3) deuterated methyl ester MOD:01241 3x(2)H labeled L-aspartic acid 4-methyl ester MOD:01241 A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-aspartic acid 4-methyl ester. OMSSA:19 PubMed:12185208 Unimod:298#D DiffAvg: 17.03 DiffFormula: C 1 (1)H -1 (2)H 3 DiffMono: 17.034480 Formula: C 5 (1)H 4 (2)H 3 N 1 O 3 MassAvg: 132.06 MassMono: 132.061423 Origin: D Source: artifact TermSpec: none Unimod: Unimod:298 trideuteromethyld Methyl:2H(3) deuterated methyl ester A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-glutamic acid 5-methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: trideuteromethyle PSI-MOD Methyl:2H(3) deuterated methyl ester MOD:01242 3x(2)H labeled L-glutamic acid 5-methyl ester MOD:01242 A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-glutamic acid 5-methyl ester. OMSSA:20 PubMed:1326520 Unimod:298#E DiffAvg: 17.03 DiffFormula: C 1 (1)H -1 (2)H 3 DiffMono: 17.034480 Formula: C 6 (1)H 6 (2)H 3 N 1 O 3 MassAvg: 146.08 MassMono: 146.077073 Origin: E Source: artifact TermSpec: none Unimod: Unimod:298 trideuteromethyle Methyl:2H(3) deuterated methyl ester A protein modification that effectively converts a C-terminal residue to the potassium carboxylate salt. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cation:K Replacement of proton by potassium MOD:01243 potassium carboxylate C-terminal residue MOD:01243 A protein modification that effectively converts a C-terminal residue to the potassium carboxylate salt. Unimod:530#C-term DiffAvg: 38.09 DiffFormula: H -1 K 1 DiffMono: 37.955882 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: C-term Unimod: Unimod:530 Cation:K Replacement of proton by potassium A protein modification that effectively converts an L-glutamioc acid residue to the potassium glutamate salt. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cation:K Replacement of proton by potassium MOD:01244 potassium L-glutamate MOD:01244 A protein modification that effectively converts an L-glutamioc acid residue to the potassium glutamate salt. Unimod:530#E DiffAvg: 38.09 DiffFormula: H -1 K 1 DiffMono: 37.955882 Formula: C 5 H 6 K 1 N 1 O 3 MassAvg: 167.21 MassMono: 166.998475 Origin: E Source: none TermSpec: none Unimod: Unimod:530 Cation:K Replacement of proton by potassium A protein modification that effectively converts an L-aspartic acid residue to the potassium aspartate salt. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cation:K Replacement of proton by potassium MOD:01245 potassium L-aspartate MOD:01245 A protein modification that effectively converts an L-aspartic acid residue to the potassium aspartate salt. Unimod:530#D DiffAvg: 38.09 DiffFormula: H -1 K 1 DiffMono: 37.955882 Formula: C 4 H 4 K 1 N 1 O 3 MassAvg: 153.18 MassMono: 152.982825 Origin: D Source: none TermSpec: none Unimod: Unimod:530 Cation:K Replacement of proton by potassium OBSOLETE because redundant and identical to MOD:00812 after formula correction. Remap to MOD:00812. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Fucose dHex MOD:01246 fucosylated -site S true MOD:01246 OBSOLETE because redundant and identical to MOD:00812 after formula correction. Remap to MOD:00812. PubMed:11344537 PubMed:15189151 PubMed:3311742 PubMed:3578767 Unimod:295#S DiffAvg: 147.15 DiffFormula: C 6 H 11 O 4 DiffMono: 147.065734 Formula: C 9 H 16 N 1 O 6 MassAvg: 234.23 MassMono: 234.097762 Origin: S Remap: MOD:00812 Source: natural TermSpec: none Unimod: Unimod:295 Fucose dHex OBSOLETE because redundant and identical to MOD:00813 after formula correction. Remap to MOD:00813. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Fucose dHex MOD:01247 fucosylated -site T true MOD:01247 OBSOLETE because redundant and identical to MOD:00813 after formula correction. Remap to MOD:00813. PubMed:11344537 PubMed:11857757 PubMed:15189151 Unimod:295#T DiffAvg: 147.15 DiffFormula: C 6 H 11 O 4 DiffMono: 147.065734 Formula: C 10 H 18 N 1 O 6 MassAvg: 248.26 MassMono: 248.113412 Origin: T Remap: MOD:00813 Source: natural TermSpec: none Unimod: Unimod:295 Fucose dHex A protein modification that is produced by reaction of iodouridine monophosphate with an L-tyrosine residue to form an ether linkage. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cross-link of (Iodo)-uracil MP with W,F,Y IodoU-AMP MOD:01248 This has an ether linkage and not a phosphodiester linkage with UMP. iodouridine monophosphate derivatized tyrosine MOD:01248 A protein modification that is produced by reaction of iodouridine monophosphate with an L-tyrosine residue to form an ether linkage. PubMed:11112526 PubMed:11567090 PubMed:6540775 Unimod:292#Y DiffAvg: 322.17 DiffFormula: C 9 H 11 N 2 O 9 P 1 DiffMono: 322.020217 Formula: C 18 H 20 N 3 O 11 P 1 MassAvg: 485.34 MassMono: 485.083545 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:292 Cross-link of (Iodo)-uracil MP with W,F,Y IodoU-AMP A protein modification that is produced by reaction of iodouridine monophosphate with an L-tryptophan residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cross-link of (Iodo)-uracil MP with W,F,Y IodoU-AMP MOD:01249 This has a carbon-nitrogen linkage and not a phosphodiester linkage with UMP. iodouridine monophosphate derivatized tryptophan MOD:01249 A protein modification that is produced by reaction of iodouridine monophosphate with an L-tryptophan residue. PubMed:11112526 PubMed:11567090 PubMed:6540775 Unimod:292#W DiffAvg: 322.17 DiffFormula: C 9 H 11 N 2 O 9 P 1 DiffMono: 322.020217 Formula: C 20 H 21 N 4 O 10 P 1 MassAvg: 508.38 MassMono: 508.099530 Origin: W Source: artifact TermSpec: none Unimod: Unimod:292 Cross-link of (Iodo)-uracil MP with W,F,Y IodoU-AMP A protein modification that is produced by reaction of iodouridine monophosphate with an L-phenylalanine residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cross-link of (Iodo)-uracil MP with W,F,Y IodoU-AMP MOD:01250 This has a carbon-carbon linkage and not a phosphodiester linkage with UMP. iodouridine monophosphate derivatized phenylalanine MOD:01250 A protein modification that is produced by reaction of iodouridine monophosphate with an L-phenylalanine residue. PubMed:11112526 PubMed:11567090 PubMed:6540775 Unimod:292#F DiffAvg: 322.17 DiffFormula: C 9 H 11 N 2 O 9 P 1 DiffMono: 322.020217 Formula: C 18 H 20 N 3 O 10 P 1 MassAvg: 469.34 MassMono: 469.088630 Origin: F Source: artifact TermSpec: none Unimod: Unimod:292 Cross-link of (Iodo)-uracil MP with W,F,Y IodoU-AMP A protein modification that effectively converts an L-lysine residue to N6-[3-(carboxamidomethylthio)propanoyl]lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 3-(carbamidomethylthio)propanoyl CAMthiopropanoyl MOD:01251 N6-[3-(carboxamidomethylthio)propanoyl]lysine MOD:01251 A protein modification that effectively converts an L-lysine residue to N6-[3-(carboxamidomethylthio)propanoyl]lysine. PubMed:15121203 Unimod:293#K DiffAvg: 145.18 DiffFormula: C 5 H 7 N 1 O 2 S 1 DiffMono: 145.019749 Formula: C 11 H 19 N 3 O 3 S 1 MassAvg: 273.35 MassMono: 273.114712 Origin: K Source: artifact TermSpec: none Unimod: Unimod:293 3-(carbamidomethylthio)propanoyl CAMthiopropanoyl OBSOLETE because redundant and identical to MOD:00933. Remap to MOD:00933. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Delta:H(2)C(3)O(1) MDA adduct +54 MOD:01252 5-hydro-5-methylimidazol-4-one, methylglyoxal arginine adduct (+54 amu) true MOD:01252 OBSOLETE because redundant and identical to MOD:00933. Remap to MOD:00933. PubMed:9448752 Unimod:319#R DiffAvg: 54.05 DiffFormula: C 3 H 2 O 1 DiffMono: 54.010565 Formula: C 9 H 14 N 4 O 2 MassAvg: 210.24 MassMono: 210.111676 Origin: R Remap: MOD:00933 Source: artifact TermSpec: none Unimod: Unimod:319 Delta:H(2)C(3)O(1) MDA adduct +54 modification from Unimod Chemical derivative - Malondialdehyde (MDA) adduct DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:H(2)C(3)O(1) MDA adduct +54 MOD:01253 malondialdehyde lysine adduct (+54 amu) MOD:01253 modification from Unimod Chemical derivative - Malondialdehyde (MDA) adduct Unimod:319#K DiffAvg: 54.05 DiffFormula: C 3 H 2 O 1 DiffMono: 54.010565 Formula: C 9 H 14 N 2 O 2 MassAvg: 182.22 MassMono: 182.105528 Origin: K Source: artifact TermSpec: none Unimod: Unimod:319 Delta:H(2)C(3)O(1) MDA adduct +54 A protein modification that effectively converts an L-lysine residue to 4x(2)H labeled dimethylated L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: mod189 PSI-MOD DiMethyl-CHD2 Dimethyl:2H(4) MOD:01254 4x(2)H labeled dimethylated L-lysine MOD:01254 A protein modification that effectively converts an L-lysine residue to 4x(2)H labeled dimethylated L-lysine. OMSSA:189 PubMed:14670044 Unimod:199#K DiffAvg: 32.06 DiffFormula: C 2 (2)H 4 DiffMono: 32.056407 Formula: C 8 H 12 (2)H 4 N 2 O 1 MassAvg: 160.15 MassMono: 160.151370 Origin: K Source: artifact TermSpec: none Unimod: Unimod:199 mod189 DiMethyl-CHD2 Dimethyl:2H(4) A protein modification that effectively converts an L-serine residue to S-(2-sulfanylethyl)cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: S-(2-mercaptoethyl)cysteine PSI-MOD EDT Ethanedithiol MOD:01255 S-(2-sulfanylethyl)cysteine (Ser) MOD:01255 A protein modification that effectively converts an L-serine residue to S-(2-sulfanylethyl)cysteine. PubMed:11507762 Unimod:200#S DiffAvg: 76.18 DiffFormula: C 2 H 4 O -1 S 2 DiffMono: 75.980528 Formula: C 5 H 9 N 1 O 1 S 2 MassAvg: 163.25 MassMono: 163.012556 Origin: S Source: artifact TermSpec: none Unimod: Unimod:200 S-(2-mercaptoethyl)cysteine EDT Ethanedithiol A protein modification that effectively converts an L-threonine residue to 3-methyl-S-(2-sulfanylethyl)cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: beta-methyl-S-(2-mercaptoethyl)cysteine PSI-MOD EDT Ethanedithiol MOD:01256 3-methyl-S-(2-sulfanylethyl)cysteine (Thr) MOD:01256 A protein modification that effectively converts an L-threonine residue to 3-methyl-S-(2-sulfanylethyl)cysteine. PubMed:11507762 Unimod:200#T DiffAvg: 76.18 DiffFormula: C 2 H 4 O -1 S 2 DiffMono: 75.980528 Formula: C 6 H 11 N 1 O 1 S 2 MassAvg: 177.28 MassMono: 177.028206 Origin: T Source: artifact TermSpec: none Unimod: Unimod:200 beta-methyl-S-(2-mercaptoethyl)cysteine EDT Ethanedithiol modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate AccQTag MOD:01257 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate - site K MOD:01257 modification from Unimod Chemical derivative - PubMed:12716131 PubMed:14997490 Unimod:194#K DiffAvg: 170.17 DiffFormula: C 10 H 6 N 2 O 1 DiffMono: 170.048013 Formula: C 16 H 18 N 4 O 2 MassAvg: 298.35 MassMono: 298.142976 Origin: K Source: artifact TermSpec: none Unimod: Unimod:194 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate AccQTag modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Nmethylmaleimide MOD:01258 N-methylmaleimide modified L-cysteine MOD:01258 modification from Unimod Chemical derivative - PubMed:9448752 Unimod:314#C DiffAvg: 111.10 DiffFormula: C 5 H 5 N 1 O 2 DiffMono: 111.032028 Formula: C 8 H 10 N 2 O 3 S 1 MassAvg: 214.24 MassMono: 214.041213 Origin: C Source: artifact TermSpec: none Unimod: Unimod:314 Nmethylmaleimide Nmethylmaleimide modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Nmethylmaleimide MOD:01259 N-methylmaleimide modified L-lysine MOD:01259 modification from Unimod Chemical derivative - PubMed:9448752 Unimod:314#K DiffAvg: 111.10 DiffFormula: C 5 H 5 N 1 O 2 DiffMono: 111.032028 Formula: C 11 H 17 N 3 O 3 MassAvg: 239.27 MassMono: 239.126991 Origin: K Source: artifact TermSpec: none Unimod: Unimod:314 Nmethylmaleimide Nmethylmaleimide OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne nucleophilic addtion to cytopiloyne MOD:01260 nucleophilic addtion to cytopiloyne - site Y true MOD:01260 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:15549660 Unimod:270#Y DiffAvg: 362.38 DiffFormula: C 19 H 22 O 7 DiffMono: 362.136553 Formula: C 28 H 31 N 1 O 9 MassAvg: 525.55 MassMono: 525.199882 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:270 Cytopiloyne nucleophilic addtion to cytopiloyne OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne nucleophilic addtion to cytopiloyne MOD:01261 nucleophilic addtion to cytopiloyne - site S true MOD:01261 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:15549660 Unimod:270#C DiffAvg: 362.38 DiffFormula: C 19 H 22 O 7 DiffMono: 362.136553 Formula: C 22 H 27 N 1 O 9 MassAvg: 449.46 MassMono: 449.168581 Origin: S Source: artifact TermSpec: none Unimod: Unimod:270 Cytopiloyne nucleophilic addtion to cytopiloyne OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne nucleophilic addtion to cytopiloyne MOD:01262 nucleophilic addition to cytopiloyne - site R true MOD:01262 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:12590383 PubMed:15549660 Unimod:270#R DiffAvg: 362.38 DiffFormula: C 19 H 22 O 7 DiffMono: 362.136553 Formula: C 25 H 34 N 4 O 8 MassAvg: 518.57 MassMono: 518.237664 Origin: R Source: artifact TermSpec: none Unimod: Unimod:270 Cytopiloyne nucleophilic addtion to cytopiloyne OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne nucleophilic addtion to cytopiloyne MOD:01263 nucleophilic addtion to cytopiloyne - site K true MOD:01263 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:15549660 Unimod:270#K DiffAvg: 362.38 DiffFormula: C 19 H 22 O 7 DiffMono: 362.136553 Formula: C 25 H 34 N 2 O 8 MassAvg: 490.55 MassMono: 490.231516 Origin: K Source: artifact TermSpec: none Unimod: Unimod:270 Cytopiloyne nucleophilic addtion to cytopiloyne OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne nucleophilic addtion to cytopiloyne MOD:01264 nucleophilic addtion to cytopiloyne - site C true MOD:01264 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:15549660 Unimod:270#C DiffAvg: 362.38 DiffFormula: C 19 H 22 O 7 DiffMono: 362.136553 Formula: C 22 H 27 N 1 O 8 S 1 MassAvg: 465.52 MassMono: 465.145738 Origin: C Source: artifact TermSpec: none Unimod: Unimod:270 Cytopiloyne nucleophilic addtion to cytopiloyne OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne nucleophilic addtion to cytopiloyne MOD:01265 nucleophilic addtion to cytopiloyne - site P true MOD:01265 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:15549660 Unimod:270#P DiffAvg: 362.38 DiffFormula: C 19 H 22 O 7 DiffMono: 362.136553 Formula: C 24 H 29 N 1 O 8 MassAvg: 459.50 MassMono: 459.189317 Origin: P Source: artifact TermSpec: none Unimod: Unimod:270 Cytopiloyne nucleophilic addtion to cytopiloyne OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O MOD:01266 nucleophilic addition to cytopiloyne+H2O - site C true MOD:01266 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:15549660 Unimod:271#C DiffAvg: 380.39 DiffFormula: C 19 H 24 O 8 DiffMono: 380.147118 Formula: C 22 H 29 N 1 O 9 S 1 MassAvg: 483.53 MassMono: 483.156303 Origin: C Source: artifact TermSpec: none Unimod: Unimod:271 Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O MOD:01267 nucleophilic addition to cytopiloyne+H2O - site K true MOD:01267 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:11746907 PubMed:15549660 Unimod:271#K DiffAvg: 380.39 DiffFormula: C 19 H 24 O 8 DiffMono: 380.147118 Formula: C 25 H 36 N 2 O 9 MassAvg: 508.57 MassMono: 508.242081 Origin: K Source: artifact TermSpec: none Unimod: Unimod:271 Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O MOD:01268 nucleophilic addition to cytopiloyne+H2O - site T true MOD:01268 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:15549660 Unimod:271#T DiffAvg: 380.39 DiffFormula: C 19 H 24 O 8 DiffMono: 380.147118 Formula: C 23 H 31 N 1 O 10 MassAvg: 481.50 MassMono: 481.194796 Origin: T Source: artifact TermSpec: none Unimod: Unimod:271 Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O MOD:01269 nucleophilic addition to cytopiloyne+H2O - site R true MOD:01269 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:15549660 Unimod:271#R DiffAvg: 380.39 DiffFormula: C 19 H 24 O 8 DiffMono: 380.147118 Formula: C 25 H 36 N 4 O 9 MassAvg: 536.58 MassMono: 536.248229 Origin: R Source: artifact TermSpec: none Unimod: Unimod:271 Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O MOD:01270 nucleophilic addition to cytopiloyne+H2O - site S true MOD:01270 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:14670044 PubMed:15549660 Unimod:271#S DiffAvg: 380.39 DiffFormula: C 19 H 24 O 8 DiffMono: 380.147118 Formula: C 22 H 29 N 1 O 10 MassAvg: 467.47 MassMono: 467.179146 Origin: S Source: artifact TermSpec: none Unimod: Unimod:271 Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O MOD:01271 nucleophilic addition to cytopiloyne+H2O - site Y true MOD:01271 OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O. Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative - PubMed:15549660 Unimod:271#Y DiffAvg: 380.39 DiffFormula: C 19 H 24 O 8 DiffMono: 380.147118 Formula: C 28 H 33 N 1 O 10 MassAvg: 543.57 MassMono: 543.210446 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:271 Cytopiloyne+water nucleophilic addition to cytopiloyne+H2O modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Iminobiotin Iminobiotinylation MOD:01272 iminobiotinylation - site K MOD:01272 modification from Unimod Chemical derivative - PubMed:9750125 Unimod:89#K DiffAvg: 225.31 DiffFormula: C 10 H 15 N 3 O 1 S 1 DiffMono: 225.093583 Formula: C 16 H 27 N 5 O 2 S 1 MassAvg: 353.49 MassMono: 353.188546 Origin: K Source: artifact TermSpec: none Unimod: Unimod:89 Iminobiotin Iminobiotinylation A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-serine residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD AEBS Aminoethylbenzenesulfonylation MOD:01273 O-[4-(2-aminoethyl)benzenesulfonyl] serine MOD:01273 A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-serine residue. PubMed:15283597 PubMed:8597590 Unimod:276#S DiffAvg: 183.23 DiffFormula: C 8 H 9 N 1 O 2 S 1 DiffMono: 183.035400 Formula: C 11 H 14 N 2 O 4 S 1 MassAvg: 270.30 MassMono: 270.067428 Origin: S Source: artifact TermSpec: none Unimod: Unimod:276 AEBS Aminoethylbenzenesulfonylation A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-histidine residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD AEBS Aminoethylbenzenesulfonylation MOD:01274 N'-[4-(2-aminoethyl)benzenesulfonyl] derivatized histidine MOD:01274 A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-histidine residue. PubMed:8597590 Unimod:276#H DiffAvg: 183.23 DiffFormula: C 8 H 9 N 1 O 2 S 1 DiffMono: 183.035400 Formula: C 14 H 16 N 4 O 3 S 1 MassAvg: 320.37 MassMono: 320.094311 Origin: H Source: artifact TermSpec: none Unimod: Unimod:276 AEBS Aminoethylbenzenesulfonylation A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-lysine residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD AEBS Aminoethylbenzenesulfonylation MOD:01275 N6-[4-(2-aminoethyl)benzenesulfonyl]lysine MOD:01275 A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-lysine residue. PubMed:8597590 Unimod:276#K DiffAvg: 183.23 DiffFormula: C 8 H 9 N 1 O 2 S 1 DiffMono: 183.035400 Formula: C 14 H 21 N 3 O 3 S 1 MassAvg: 311.40 MassMono: 311.130363 Origin: K Source: artifact TermSpec: none Unimod: Unimod:276 AEBS Aminoethylbenzenesulfonylation A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-tyrosine residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD AEBS Aminoethylbenzenesulfonylation MOD:01276 O4'-[4-(2-aminoethyl)benzenesulfonyl]tyrosine MOD:01276 A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-tyrosine residue. PubMed:10906242 PubMed:8597590 Unimod:276#Y DiffAvg: 183.23 DiffFormula: C 8 H 9 N 1 O 2 S 1 DiffMono: 183.035400 Formula: C 17 H 18 N 2 O 4 S 1 MassAvg: 346.40 MassMono: 346.098728 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:276 AEBS Aminoethylbenzenesulfonylation modification from Unimod Other - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Crotonaldehyde MOD:01277 crotonylated L-cysteine MOD:01277 modification from Unimod Other - PubMed:11283024 Unimod:253#C DiffAvg: 70.09 DiffFormula: C 4 H 6 O 1 DiffMono: 70.041865 Formula: C 7 H 11 N 1 O 2 S 1 MassAvg: 173.23 MassMono: 173.051050 Origin: C Source: artifact TermSpec: none Unimod: Unimod:253 Crotonaldehyde Crotonaldehyde modification from Unimod Other - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Crotonaldehyde MOD:01278 crotonylated L-lysine MOD:01278 modification from Unimod Other - PubMed:11283024 Unimod:253#K DiffAvg: 70.09 DiffFormula: C 4 H 6 O 1 DiffMono: 70.041865 Formula: C 10 H 18 N 2 O 2 MassAvg: 198.27 MassMono: 198.136828 Origin: K Source: artifact TermSpec: none Unimod: Unimod:253 Crotonaldehyde Crotonaldehyde modification from Unimod Other - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Crotonaldehyde MOD:01279 crotonylated L-histidine MOD:01279 modification from Unimod Other - PubMed:11283024 PubMed:1443554 Unimod:253#H DiffAvg: 70.09 DiffFormula: C 4 H 6 O 1 DiffMono: 70.041865 Formula: C 10 H 13 N 3 O 2 MassAvg: 207.23 MassMono: 207.100777 Origin: H Source: artifact TermSpec: none Unimod: Unimod:253 Crotonaldehyde Crotonaldehyde modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD EDT-iodo-PEO-biotin EDT-iodoacetyl-PEO-biotin MOD:01280 EDT-iodo-PEO-biotin - site T MOD:01280 modification from Unimod Chemical derivative - PubMed:11857757 PubMed:12175151 Unimod:118#T DiffAvg: 490.70 DiffFormula: C 20 H 34 N 4 O 4 S 3 DiffMono: 490.174219 Formula: C 24 H 41 N 5 O 6 S 3 MassAvg: 591.80 MassMono: 591.221897 Origin: T Source: artifact TermSpec: none Unimod: Unimod:118 EDT-iodo-PEO-biotin EDT-iodoacetyl-PEO-biotin modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD EDT-iodo-PEO-biotin EDT-iodoacetyl-PEO-biotin MOD:01281 EDT-iodo-PEO-biotin - site S MOD:01281 modification from Unimod Chemical derivative - PubMed:16335955 Unimod:118#S DiffAvg: 490.70 DiffFormula: C 20 H 34 N 4 O 4 S 3 DiffMono: 490.174219 Formula: C 23 H 39 N 5 O 6 S 3 MassAvg: 577.77 MassMono: 577.206247 Origin: S Source: artifact TermSpec: none Unimod: Unimod:118 EDT-iodo-PEO-biotin EDT-iodoacetyl-PEO-biotin OBSOLETE because this modification is not supported by the linked literature [PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acrolein addition +56 Delta:H(4)C(3)O(1) MOD:01282 acrolein addition +56 - site H true MOD:01282 OBSOLETE because this modification is not supported by the linked literature [PMT] PubMed:10825247 PubMed:15541752 Unimod:206#H DiffAvg: 56.06 DiffFormula: C 3 H 4 O 1 DiffMono: 56.026215 Formula: C 9 H 11 N 3 O 2 MassAvg: 193.21 MassMono: 193.085127 Origin: H Source: artifact TermSpec: none Unimod: Unimod:206 Acrolein addition +56 Delta:H(4)C(3)O(1) OBSOLETE because this modification is not supported by the linked literature [PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acrolein addition +56 Delta:H(4)C(3)O(1) MOD:01283 acrolein addition +56 - site K true MOD:01283 OBSOLETE because this modification is not supported by the linked literature [PMT] PubMed:10825247 PubMed:15541752 Unimod:206#K DiffAvg: 56.06 DiffFormula: C 3 H 4 O 1 DiffMono: 56.026215 Formula: C 9 H 16 N 2 O 2 MassAvg: 184.24 MassMono: 184.121178 Origin: K Source: artifact TermSpec: none Unimod: Unimod:206 Acrolein addition +56 Delta:H(4)C(3)O(1) OBSOLETE because this modification is not supported by the linked literature [PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acrolein addition +56 Delta:H(4)C(3)O(1) MOD:01284 acrolein addition +56 - site C true MOD:01284 OBSOLETE because this modification is not supported by the linked literature [PMT] PubMed:10825247 PubMed:15541752 PubMed:9254591 Unimod:206#C DiffAvg: 56.06 DiffFormula: C 3 H 4 O 1 DiffMono: 56.026215 Formula: C 6 H 9 N 1 O 2 S 1 MassAvg: 159.20 MassMono: 159.035400 Origin: C Source: artifact TermSpec: none Unimod: Unimod:206 Acrolein addition +56 Delta:H(4)C(3)O(1) A protein modification that effectively converts an L-leucine residue to 6x(13)C,1x(15)N isotope labeled L-leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(6) 15N(1) Silac label Label:13C(6)15N(1) MOD:01285 6x(13)C,1x(15)N labeled L-leucine MOD:01285 A protein modification that effectively converts an L-leucine residue to 6x(13)C,1x(15)N isotope labeled L-leucine. PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:695#L DiffAvg: 7.02 DiffFormula: (12)C -6 (13)C 6 (14)N -1 (15)N 1 DiffMono: 7.017164 Formula: (13)C 6 H 11 (15)N 1 O 1 MassAvg: 120.10 MassMono: 120.101228 Origin: L Source: artifact TermSpec: none Unimod: Unimod:695 13C(6) 15N(1) Silac label Label:13C(6)15N(1) A protein modification that effectively converts an L-isoleucine residue to 6x(13)C,1x(15)N isotope labeled L-isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(6) 15N(1) Silac label Label:13C(6)15N(1) MOD:01286 6x(13)C,1x(15)N labeled L-isoleucine MOD:01286 A protein modification that effectively converts an L-isoleucine residue to 6x(13)C,1x(15)N isotope labeled L-isoleucine. PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:695#I DiffAvg: 7.02 DiffFormula: (12)C -6 (13)C 6 (14)N -1 (15)N 1 DiffMono: 7.017164 Formula: (13)C 6 H 11 (15)N 1 O 1 MassAvg: 120.10 MassMono: 120.101228 Origin: I Source: artifact TermSpec: none Unimod: Unimod:695 13C(6) 15N(1) Silac label Label:13C(6)15N(1) modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form ICPL:13C(6) MOD:01287 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form - site K MOD:01287 modification from Unimod Isotopic label - PubMed:11857757 PubMed:15602776 Unimod:364#K DiffAvg: 111.04 DiffFormula: (13)C 6 H 3 N 1 O 1 DiffMono: 111.041593 Formula: C 6 (13)C 6 H 15 N 3 O 2 MassAvg: 239.14 MassMono: 239.136556 Origin: K Source: artifact TermSpec: none Unimod: Unimod:364 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form ICPL:13C(6) OBSOLETE because this is not supported by the literature [PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acetaldehyde +28 Delta:H(4)C(2) MOD:01288 acetaldehyde +28 - site H true MOD:01288 OBSOLETE because this is not supported by the literature [PMT] Unimod:255#H DiffAvg: 28.05 DiffFormula: C 2 H 4 DiffMono: 28.031300 Formula: C 8 H 11 N 3 O 1 MassAvg: 165.20 MassMono: 165.090212 Origin: H Source: artifact TermSpec: none Unimod: Unimod:255 Acetaldehyde +28 Delta:H(4)C(2) OBSOLETE because this is not supported by the literature [PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acetaldehyde +28 Delta:H(4)C(2) MOD:01289 acetaldehyde +28 - site K true MOD:01289 OBSOLETE because this is not supported by the literature [PMT] Unimod:255#K DiffAvg: 28.05 DiffFormula: C 2 H 4 DiffMono: 28.031300 Formula: C 8 H 16 N 2 O 1 MassAvg: 156.23 MassMono: 156.126263 Origin: K Source: artifact TermSpec: none Unimod: Unimod:255 Acetaldehyde +28 Delta:H(4)C(2) OBSOLETE because redundant and identical to MOD:00465. Remap to MOD:00465. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Dioxidation dihydroxy MOD:01290 dihydroxylated residue - site F true MOD:01290 OBSOLETE because redundant and identical to MOD:00465. Remap to MOD:00465. PubMed:11857757 PubMed:12175151 PubMed:12686488 PubMed:9252331 Unimod:425 DiffAvg: 32.00 DiffFormula: O 2 DiffMono: 31.989829 Formula: C 9 H 9 N 1 O 3 MassAvg: 179.17 MassMono: 179.058243 Origin: F Remap: MOD:00465 Source: artifact TermSpec: none Unimod: Unimod:425 Dioxidation dihydroxy OBSOLETE because redundant and identical to MOD:00464. Remap to MOD:00464. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Dioxidation dihydroxy MOD:01291 dihydroxylated residue - site W true MOD:01291 OBSOLETE because redundant and identical to MOD:00464. Remap to MOD:00464. PubMed:12643539 PubMed:12686488 PubMed:6273432 PubMed:9252331 Unimod:425 DiffAvg: 32.00 DiffFormula: O 2 DiffMono: 31.989829 Formula: C 11 H 10 N 2 O 3 MassAvg: 218.21 MassMono: 218.069142 Origin: W Remap: MOD:00464 Source: artifact TermSpec: none Unimod: Unimod:425 Dioxidation dihydroxy OBSOLETE because redundant and identical to MOD:00075. Map to MOD:00075. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Delta:H(5)C(2) Dimethylation of proline residue MOD:01292 dimethylation of proline residue true MOD:01292 OBSOLETE because redundant and identical to MOD:00075. Map to MOD:00075. Unimod:529 DiffAvg: 29.06 DiffFormula: C 2 H 5 DiffMono: 29.039125 Formula: none MassAvg: none MassMono: none Origin: P Remap: MOD:00075 Source: natural TermSpec: none Unimod: Unimod:529 Delta:H(5)C(2) Dimethylation of proline residue A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: oxy18 PSI-MOD Deamidated:18O(1) Deamidation in presence of O18 MOD:01293 1x(18)O labeled deamidated L-asparagine MOD:01293 A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O. OMSSA:139 PubMed:8382902 Unimod:366#N DiffAvg: 2.99 DiffFormula: H -1 N -1 (18)O 1 DiffMono: 2.988262 Formula: C 4 H 5 N 1 (16)O 2 (18)O 1 MassAvg: 117.03 MassMono: 117.031189 Origin: N Source: artifact TermSpec: none Unimod: Unimod:366 oxy18 Deamidated:18O(1) Deamidation in presence of O18 OBSOLETE identical and redundant with MOD:00791. Remap to MOD:00791. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD Deamidated:18O(1) Deamidation in presence of O18 MOD:01294 deamidation in presence of O18 -site Q true MOD:01294 OBSOLETE identical and redundant with MOD:00791. Remap to MOD:00791. PubMed:8382902 DiffAvg: 2.99 DiffFormula: H -1 N -1 (18)O 1 DiffMono: 2.988262 Formula: none MassAvg: none MassMono: none Origin: Q Remap: MOD:00791 Source: artifact TermSpec: none Deamidated:18O(1) Deamidation in presence of O18 A protein modification that effectively converts an L-aspartic acid residue to monosodium L-aspartate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Na1Asp PSI-MOD Cation:Na Sodium adduct MOD:01295 monosodium L-aspartate MOD:01295 A protein modification that effectively converts an L-aspartic acid residue to monosodium L-aspartate. PubMed:12216740 Unimod:30#D DiffAvg: 21.98 DiffFormula: H -1 Na 1 DiffMono: 21.981944 Formula: C 4 H 4 N 1 Na 1 O 3 MassAvg: 137.07 MassMono: 137.008887 Origin: D Source: artifact TermSpec: none Unimod: Unimod:30 Na1Asp Cation:Na Sodium adduct A protein modification that effectively converts an L-glutamic acid residue to monosodium L-glutamate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: MSG Na1Glu PSI-MOD Cation:Na Sodium adduct MOD:01296 monosodium L-glutamate MOD:01296 A protein modification that effectively converts an L-glutamic acid residue to monosodium L-glutamate. PubMed:12216740 Unimod:30#E DiffAvg: 21.98 DiffFormula: H -1 Na 1 DiffMono: 21.981944 Formula: C 5 H 6 N 1 Na 1 O 3 MassAvg: 151.10 MassMono: 151.024537 Origin: E Source: artifact TermSpec: none Unimod: Unimod:30 MSG Na1Glu Cation:Na Sodium adduct A protein modification that effectively converts an L-proline residue to 5x(13)C labeled L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(5) Silac label Label:13C(5) MOD:01297 In PubMed:12716131, fully (13)C labeled proline apparently resulted from the catabolic conversion of (13)C labeled L-arginine during SILAC. 5x(13)C labeled L-proline MOD:01297 A protein modification that effectively converts an L-proline residue to 5x(13)C labeled L-proline. PubMed:12716131 Unimod:772#P DiffAvg: 5.02 DiffFormula: (12)C -5 (13)C 5 DiffMono: 5.016774 Formula: (13)C 5 H 7 N 1 O 1 MassAvg: 102.07 MassMono: 102.069538 Origin: P Source: artifact TermSpec: none Unimod: Unimod:772 13C(5) Silac label Label:13C(5) A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HNE+Delta:H(2) reduced 4-Hydroxynonenal MOD:01298 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. reduced cysteine 4-hydroxynonenal adduct MOD:01298 A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. PubMed:11910026 PubMed:15133838 Unimod:335#C DiffAvg: 158.24 DiffFormula: C 9 H 18 O 2 DiffMono: 158.130680 Formula: C 12 H 23 N 1 O 3 S 1 MassAvg: 261.38 MassMono: 261.139865 Origin: C Source: artifact TermSpec: none Unimod: Unimod:335 HNE+Delta:H(2) reduced 4-Hydroxynonenal A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HNE+Delta:H(2) reduced 4-Hydroxynonenal MOD:01299 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. reduced lysine 4-hydroxynonenal adduct MOD:01299 A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. PubMed:11910026 PubMed:12148805 PubMed:15133838 Unimod:335#K DiffAvg: 158.24 DiffFormula: C 9 H 18 O 2 DiffMono: 158.130680 Formula: C 15 H 30 N 2 O 3 MassAvg: 286.42 MassMono: 286.225643 Origin: K Source: artifact TermSpec: none Unimod: Unimod:335 HNE+Delta:H(2) reduced 4-Hydroxynonenal A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HNE+Delta:H(2) reduced 4-Hydroxynonenal MOD:01300 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG]. reduced histidine 4-hydroxynonenal adduct MOD:01300 A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4. PubMed:11910026 PubMed:12148805 PubMed:15133838 Unimod:335#H DiffAvg: 158.24 DiffFormula: C 9 H 18 O 2 DiffMono: 158.130680 Formula: C 15 H 25 N 3 O 3 MassAvg: 295.38 MassMono: 295.189592 Origin: H Source: artifact TermSpec: none Unimod: Unimod:335 HNE+Delta:H(2) reduced 4-Hydroxynonenal A protein modification that effectively converts an L-threonine residue to 2-amino-3-(methylamino)butanoic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Methylamine Michael addition with methylamine MOD:01301 In PubMed:11743741 phosphothreonine is converted to dehydrobutyrine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)butanoic acid. methylamine Michael addition derivatized threonine MOD:01301 A protein modification that effectively converts an L-threonine residue to 2-amino-3-(methylamino)butanoic acid. PubMed:11743741 Unimod:337#T DiffAvg: 13.04 DiffFormula: C 1 H 3 N 1 O -1 DiffMono: 13.031634 Formula: C 5 H 10 N 2 O 1 MassAvg: 114.15 MassMono: 114.079313 Origin: T Source: artifact TermSpec: none Unimod: Unimod:337 Methylamine Michael addition with methylamine A protein modification that effectively converts an L-serine residue to 2-amino-3-(methylamino)propanoic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Methylamine Michael addition with methylamine MOD:01302 In PubMed:11743741 phosphoserine is converted to dehydroalanine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)propanoic acid. methylamine Michael addition derivatized serine MOD:01302 A protein modification that effectively converts an L-serine residue to 2-amino-3-(methylamino)propanoic acid. PubMed:11743741 Unimod:337#S DiffAvg: 13.04 DiffFormula: C 1 H 3 N 1 O -1 DiffMono: 13.031634 Formula: C 4 H 8 N 2 O 1 MassAvg: 100.12 MassMono: 100.063663 Origin: S Source: artifact TermSpec: none Unimod: Unimod:337 Methylamine Michael addition with methylamine A protein modification that effectively converts an L-asparagine residue to an N4-hexosaminyl-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HexN Hexosamine MOD:01303 The natural modifications are N4-(N-acetylamino)galactosyl-L-asparagine (MOD:00832) or N4-(N-acetylamino)glucosyl-L-asparagine (MOD:00831) [JSG]. N4-hexosaminylated asparagine MOD:01303 A protein modification that effectively converts an L-asparagine residue to an N4-hexosaminyl-L-asparagine. PubMed:11467524 Unimod:454#N DiffAvg: 161.16 DiffFormula: C 6 H 11 N 1 O 4 DiffMono: 161.068808 Formula: C 10 H 17 N 3 O 6 MassAvg: 275.26 MassMono: 275.111735 Origin: N Source: artifact TermSpec: none Unimod: Unimod:454 HexN Hexosamine A protein modification that effectively converts an L-lysine residue to an N4-hexosaminyl-L-lysine, as a synthetic peptide protectting group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HexN Hexosamine MOD:01304 N6-hexosaminylated lysine MOD:01304 A protein modification that effectively converts an L-lysine residue to an N4-hexosaminyl-L-lysine, as a synthetic peptide protectting group. Unimod:454#K DiffAvg: 161.16 DiffFormula: C 6 H 11 N 1 O 4 DiffMono: 161.068808 Formula: C 12 H 23 N 3 O 5 MassAvg: 289.33 MassMono: 289.163771 Origin: K Source: artifact TermSpec: none Unimod: Unimod:454 HexN Hexosamine A protein modification that effectively converts an L-tryptophan residue to N1'-hexosaminyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HexN Hexosamine MOD:01305 The natural modification is N1'-mannosyl-L-tryptophan (MOD:00165) [JSG]. N1'-hexosaminylated tryptophan MOD:01305 A protein modification that effectively converts an L-tryptophan residue to N1'-hexosaminyl-L-tryptophan. Unimod:454#W DiffAvg: 161.16 DiffFormula: C 6 H 11 N 1 O 4 DiffMono: 161.068808 Formula: C 17 H 21 N 3 O 5 MassAvg: 347.37 MassMono: 347.148121 Origin: W Source: artifact TermSpec: none Unimod: Unimod:454 HexN Hexosamine A protein modification that effectively converts an L-threonine residue to O-hexosaminyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD HexN Hexosamine MOD:01306 The natural modifications are O-(N-acetylaminogalactosyl)-L-threonine (MOD:00164) or O-(N-acetylaminoglucosyl)-L-threonine (MOD:00806) [JSG]. O-hexosaminylated threonine MOD:01306 A protein modification that effectively converts an L-threonine residue to O-hexosaminyl-L-threonine. Unimod:454#T DiffAvg: 161.16 DiffFormula: C 6 H 11 N 1 O 4 DiffMono: 161.068808 Formula: C 10 H 18 N 2 O 6 MassAvg: 262.26 MassMono: 262.116486 Origin: T Source: natural TermSpec: none Unimod: Unimod:454 HexN Hexosamine modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Thiophos-S-S-biotin thiophosphate labeled with biotin-HPDP MOD:01307 thiophosphate labeled with biotin-HPDP -site S MOD:01307 modification from Unimod Chemical derivative - Unimod:332#S DiffAvg: 525.66 DiffFormula: C 19 H 34 N 4 O 5 P 1 S 3 DiffMono: 525.142895 Formula: C 22 H 39 N 5 O 7 P 1 S 3 MassAvg: 612.74 MassMono: 612.174923 Origin: S Source: artifact TermSpec: none Unimod: Unimod:332 Thiophos-S-S-biotin thiophosphate labeled with biotin-HPDP modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Thiophos-S-S-biotin thiophosphate labeled with biotin-HPDP MOD:01308 thiophosphate labeled with biotin-HPDP -site T MOD:01308 modification from Unimod Chemical derivative - Unimod:332#T DiffAvg: 525.66 DiffFormula: C 19 H 34 N 4 O 5 P 1 S 3 DiffMono: 525.142895 Formula: C 23 H 41 N 5 O 7 P 1 S 3 MassAvg: 626.76 MassMono: 626.190573 Origin: T Source: artifact TermSpec: none Unimod: Unimod:332 Thiophos-S-S-biotin thiophosphate labeled with biotin-HPDP modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Thiophos-S-S-biotin thiophosphate labeled with biotin-HPDP MOD:01309 thiophosphate labeled with biotin-HPDP - site Y MOD:01309 modification from Unimod Chemical derivative - Unimod:332#Y DiffAvg: 525.66 DiffFormula: C 19 H 34 N 4 O 5 P 1 S 3 DiffMono: 525.142895 Formula: C 28 H 43 N 5 O 7 P 1 S 3 MassAvg: 688.83 MassMono: 688.206223 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:332 Thiophos-S-S-biotin thiophosphate labeled with biotin-HPDP A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent light form group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GIST-Quat Quaternary amine labeling reagent light form (N-term & K) MOD:01310 quaternary amine labeling reagent light form N6-L-lysine MOD:01310 A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent light form group. PubMed:11857757 Unimod:60#K DiffAvg: 59.07 DiffFormula: C 3 (1)H 9 N 1 DiffMono: 59.073499 Formula: C 9 (1)H 21 N 3 O 1 MassAvg: 187.17 MassMono: 187.168462 Origin: K Source: artifact TermSpec: none Unimod: Unimod:60 GIST-Quat Quaternary amine labeling reagent light form (N-term & K) A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+3amu) form group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GIST-Quat:2H(3) Quaternary amine labeling reagent heavy (+3amu) form, N-term & K MOD:01311 quaternary amine labeling reagent heavy form (+3amu) N6-L-lysine MOD:01311 A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+3amu) form group. PubMed:11698400 PubMed:11857757 PubMed:11914093 Unimod:61#K DiffAvg: 62.09 DiffFormula: C 3 (1)H 6 (2)H 3 N 1 DiffMono: 62.092330 Formula: C 9 (1)H 18 (2)H 3 N 3 O 1 MassAvg: 190.19 MassMono: 190.187293 Origin: K Source: artifact TermSpec: none Unimod: Unimod:61 GIST-Quat:2H(3) Quaternary amine labeling reagent heavy (+3amu) form, N-term & K A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+6amu) form group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GIST-Quat:2H(6) Quaternary amine labeling reagent heavy form (+6amu), N-term & K MOD:01312 Apparently incorrect parent [JSG]. quaternary amine labeling reagent heavy form (+6amu) N6-L-lysine MOD:01312 A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+6amu) form group. PubMed:11857757 Unimod:62#K DiffAvg: 65.11 DiffFormula: C 3 (1)H 3 (2)H 6 N 1 DiffMono: 65.111160 Formula: C 9 (1)H 15 (2)H 6 N 3 O 1 MassAvg: 193.21 MassMono: 193.206123 Origin: K Source: artifact TermSpec: none Unimod: Unimod:62 GIST-Quat:2H(6) Quaternary amine labeling reagent heavy form (+6amu), N-term & K A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+9amu) form group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD GIST-Quat:2H(9) Quaternary amine labeling reagent heavy form (+9amu), N-term & K MOD:01313 quaternary amine labeling reagent heavy form (+9amu) N6-L-lysine MOD:01313 A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+9amu) form group. PubMed:11857757 Unimod:63#K DiffAvg: 68.13 DiffFormula: C 3 (2)H 9 N 1 DiffMono: 68.129990 Formula: C 9 (1)H 12 (2)H 9 N 3 O 1 MassAvg: 196.22 MassMono: 196.224953 Origin: K Source: artifact TermSpec: none Unimod: Unimod:63 GIST-Quat:2H(9) Quaternary amine labeling reagent heavy form (+9amu), N-term & K A protein modification that effectively converts an L-lysine residue to 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Succinic anhydride labeling reagent light form (K) Succinyl MOD:01314 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine MOD:01314 A protein modification that effectively converts an L-lysine residue to 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine. PubMed:11857757 PubMed:12175151 PubMed:12716131 Unimod:64#K DiffAvg: 100.02 DiffFormula: (12)C 4 (1)H 4 O 3 DiffMono: 100.016044 Formula: (12)C 10 H 16 N 2 O 4 MassAvg: 228.11 MassMono: 228.111007 Origin: K Source: artifact TermSpec: none Unimod: Unimod:64 Succinic anhydride labeling reagent light form (K) Succinyl A protein modification that effectively converts an L-lysine residue to 4x(2)H-labeled N6-succinyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term & K Succinyl:2H(4) MOD:01315 4x(2)H labeled N6-succinyl-L-lysine MOD:01315 A protein modification that effectively converts an L-lysine residue to 4x(2)H-labeled N6-succinyl-L-lysine. PubMed:11344537 PubMed:11857757 PubMed:12175151 PubMed:15189151 Unimod:65#K DiffAvg: 104.04 DiffFormula: C 4 (2)H 4 O 3 DiffMono: 104.041151 Formula: C 10 (1)H 12 (2)H 4 N 2 O 4 MassAvg: 232.14 MassMono: 232.136114 Origin: K Source: artifact TermSpec: none Unimod: Unimod:65 Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term & K Succinyl:2H(4) A protein modification that effectively converts an L-lysine residue to 4x(13)C labeled N6-succinyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), K Succinyl:13C(4) MOD:01316 4x(13)C labeled N6-succinyl-L-lysine MOD:01316 A protein modification that effectively converts an L-lysine residue to 4x(13)C labeled N6-succinyl-L-lysine. PubMed:11344537 PubMed:11857757 PubMed:12175151 PubMed:15189151 Unimod:66#K DiffAvg: 104.03 DiffFormula: (13)C 4 H 4 O 3 DiffMono: 104.029463 Formula: (12)C 6 (13)C 4 H 16 N 2 O 4 MassAvg: 232.12 MassMono: 232.124426 Origin: K Source: artifact TermSpec: none Unimod: Unimod:66 Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), K Succinyl:13C(4) modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD DAET phosphorylation to amine thiol MOD:01317 phosphorylation to amine thiol - site T MOD:01317 modification from Unimod Chemical derivative - PubMed:12216740 Unimod:178#T DiffAvg: 87.18 DiffFormula: C 4 H 9 N 1 O -1 S 1 DiffMono: 87.050656 Formula: C 8 H 16 N 2 O 1 S 1 MassAvg: 188.29 MassMono: 188.098334 Origin: T Source: artifact TermSpec: none Unimod: Unimod:178 DAET phosphorylation to amine thiol modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD DAET phosphorylation to amine thiol MOD:01318 phosphorylation to amine thiol - site S MOD:01318 modification from Unimod Chemical derivative - PubMed:11510821 PubMed:12216740 PubMed:12422359 Unimod:178#S DiffAvg: 87.18 DiffFormula: C 4 H 9 N 1 O -1 S 1 DiffMono: 87.050656 Formula: C 7 H 14 N 2 O 1 S 1 MassAvg: 174.26 MassMono: 174.082684 Origin: S Source: artifact TermSpec: none Unimod: Unimod:178 DAET phosphorylation to amine thiol modification from Unimod Other DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD BHT Michael addition of BHT quinone methide to Cysteine and Lysine MOD:01319 Secondary adduct, much less common than cysteine. [Unimod] Michael addition of BHT quinone methide to histidine MOD:01319 modification from Unimod Other PubMed:11510821 PubMed:12422359 PubMed:9448752 Unimod:176#H DiffAvg: 218.34 DiffFormula: C 15 H 22 O 1 DiffMono: 218.167065 Formula: C 21 H 29 N 3 O 2 MassAvg: 355.48 MassMono: 355.225977 Origin: H Source: artifact TermSpec: none Unimod: Unimod:176 BHT Michael addition of BHT quinone methide to Cysteine and Lysine modification from Unimod Other DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD BHT Michael addition of BHT quinone methide to Cysteine and Lysine MOD:01320 Secondary adduct, much less common than cysteine. [Unimod] Michael addition of BHT quinone methide to lysine MOD:01320 modification from Unimod Other PubMed:16078144 PubMed:9448752 Unimod:176#K DiffAvg: 218.34 DiffFormula: C 15 H 22 O 1 DiffMono: 218.167065 Formula: C 21 H 34 N 2 O 2 MassAvg: 346.51 MassMono: 346.262028 Origin: K Source: artifact TermSpec: none Unimod: Unimod:176 BHT Michael addition of BHT quinone methide to Cysteine and Lysine modification from Unimod Other DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD BHT Michael addition of BHT quinone methide to Cysteine and Lysine MOD:01321 Primary adduct formed. [Unimod] Michael addition of BHT quinone methide to cysteine MOD:01321 modification from Unimod Other PubMed:11510821 PubMed:12422359 PubMed:9448752 Unimod:176#C DiffAvg: 218.34 DiffFormula: C 15 H 22 O 1 DiffMono: 218.167065 Formula: C 18 H 27 N 1 O 2 S 1 MassAvg: 321.48 MassMono: 321.176250 Origin: C Source: artifact TermSpec: none Unimod: Unimod:176 BHT Michael addition of BHT quinone methide to Cysteine and Lysine OBSOLETE because not supported by the linked literature [PMT]. modification from Unimod Other - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:H(4)C(3) Propionaldehyde +40 MOD:01322 propionaldehyde +40 - site K true MOD:01322 OBSOLETE because not supported by the linked literature [PMT]. modification from Unimod Other - PubMed:15549660 Unimod:256#K DiffAvg: 40.06 DiffFormula: C 3 H 4 DiffMono: 40.031300 Formula: C 9 H 16 N 2 O 1 MassAvg: 168.24 MassMono: 168.126263 Origin: K Source: artifact TermSpec: none Unimod: Unimod:256 Delta:H(4)C(3) Propionaldehyde +40 OBSOLETE because not supported by the linked literature [PMT]. modification from Unimod Other - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Delta:H(4)C(3) Propionaldehyde +40 MOD:01323 propionaldehyde +40 - site H true MOD:01323 OBSOLETE because not supported by the linked literature [PMT]. modification from Unimod Other - Unimod:256#H DiffAvg: 40.06 DiffFormula: C 3 H 4 DiffMono: 40.031300 Formula: C 9 H 11 N 3 O 1 MassAvg: 177.21 MassMono: 177.090212 Origin: H Source: artifact TermSpec: none Unimod: Unimod:256 Delta:H(4)C(3) Propionaldehyde +40 OBSOLETE because this is not supported by the linked literature [PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acetaldehyde +26 Delta:H(2)C(2) MOD:01324 acetaldehyde +26 - site H true MOD:01324 OBSOLETE because this is not supported by the linked literature [PMT] PubMed:7744761 Unimod:254#H DiffAvg: 26.04 DiffFormula: C 2 H 2 DiffMono: 26.015650 Formula: C 8 H 9 N 3 O 1 MassAvg: 163.18 MassMono: 163.074562 Origin: H Source: artifact TermSpec: none Unimod: Unimod:254 Acetaldehyde +26 Delta:H(2)C(2) OBSOLETE because this is not supported by the linked literature [PMT] DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Acetaldehyde +26 Delta:H(2)C(2) MOD:01325 acetaldehyde +26 - site K true MOD:01325 OBSOLETE because this is not supported by the linked literature [PMT] PubMed:7744761 Unimod:254#K DiffAvg: 26.04 DiffFormula: C 2 H 2 DiffMono: 26.015650 Formula: C 8 H 14 N 2 O 1 MassAvg: 154.21 MassMono: 154.110613 Origin: K Source: artifact TermSpec: none Unimod: Unimod:254 Acetaldehyde +26 Delta:H(2)C(2) A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(9) Silac label Label:13C(9) MOD:01326 9x(13)C labeled L-tyrosine MOD:01326 A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-tyrosine. PubMed:11510821 PubMed:12422359 PubMed:12716131 Unimod:184#Y DiffAvg: 9.03 DiffFormula: (12)C -9 (13)C 9 DiffMono: 9.030194 Formula: (13)C 9 H 9 N 1 O 2 MassAvg: 172.09 MassMono: 172.093522 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:184 13C(9) Silac label Label:13C(9) A protein modification that effectively converts an L-phenylalanine residue to 9x(13)C labeled L-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(9) Silac label Label:13C(9) MOD:01327 9x(13)C labeled L-phenylalanine MOD:01327 A protein modification that effectively converts an L-phenylalanine residue to 9x(13)C labeled L-phenylalanine. PubMed:12716131 Unimod:184#F DiffAvg: 9.03 DiffFormula: (12)C -9 (13)C 9 DiffMono: 9.030194 Formula: (13)C 9 H 9 N 1 O 1 MassAvg: 156.10 MassMono: 156.098607 Origin: F Source: artifact TermSpec: none Unimod: Unimod:184 13C(9) Silac label Label:13C(9) modification from Unimod Chemical derivative - hydroxylethanone DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Carboxymethyl Iodoacetic acid derivative MOD:01328 There is no citation for this Unimod entry. Iodoacetic acid derivatization of tryptophan is not mentioned in the citation [JSG]. iodoacetic acid - site W MOD:01328 modification from Unimod Chemical derivative - hydroxylethanone PubMed:17525468 Unimod:6#W DiffAvg: 58.04 DiffFormula: C 2 H 2 O 2 DiffMono: 58.005479 Formula: C 13 H 12 N 2 O 3 MassAvg: 244.25 MassMono: 244.084792 Origin: W Source: artifact TermSpec: none Unimod: Unimod:6 Carboxymethyl Iodoacetic acid derivative OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Carboxymethyl Iodoacetic acid derivative MOD:01329 Modification from Unimod Chemical derivative, Unimod:6 site C iodoacetic acid - site C true MOD:01329 OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061 DeltaMass:197 DiffAvg: 58.04 DiffFormula: C 2 H 2 O 2 DiffMono: 58.005479 Formula: none MassAvg: none MassMono: none Origin: C Remap: MOD:01061 Source: artifact TermSpec: none Unimod: Unimod:6 Carboxymethyl Iodoacetic acid derivative OBSOLETE because identical with MOD:01094. Remap to MOD:01094 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Carboxymethyl Iodoacetic acid derivative MOD:01330 a modification from Unimod:6 iodoacetic acid -site K true MOD:01330 OBSOLETE because identical with MOD:01094. Remap to MOD:01094 PubMed:18688235 DiffAvg: 58.04 DiffFormula: C 2 H 2 O 2 DiffMono: 58.005479 Formula: none MassAvg: none MassMono: none Origin: K Remap: MOD:01094 Source: artifact TermSpec: none Unimod: Unimod:6 Carboxymethyl Iodoacetic acid derivative A protein modification that effectively converts an L-arginine residue to 6x(13)C labeled L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: arg-13c6 PSI-MOD 13C(6) Silac label Label:13C(6) MOD:01331 6x(13)C labeled L-arginine MOD:01331 A protein modification that effectively converts an L-arginine residue to 6x(13)C labeled L-arginine. OMSSA:136 PubMed:12716131 Unimod:188#R DiffAvg: 6.02 DiffFormula: (12)C -6 (13)C 6 DiffMono: 6.020129 Formula: (13)C 6 H 12 N 4 O 1 MassAvg: 162.12 MassMono: 162.121240 Origin: R Source: artifact TermSpec: none Unimod: Unimod:188 arg-13c6 13C(6) Silac label Label:13C(6) A protein modification that effectively converts an L-leucine residue to 6x(13)C labeled L-leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(6) Silac label Label:13C(6) MOD:01332 6x(13)C labeled L-leucine MOD:01332 A protein modification that effectively converts an L-leucine residue to 6x(13)C labeled L-leucine. PubMed:12716131 Unimod:188#L DiffAvg: 6.02 DiffFormula: (12)C -6 (13)C 6 DiffMono: 6.020129 Formula: (13)C 6 H 11 N 1 O 1 MassAvg: 119.10 MassMono: 119.104193 Origin: L Source: artifact TermSpec: none Unimod: Unimod:188 13C(6) Silac label Label:13C(6) A protein modification that effectively converts an L-isoleucine residue to 6x(13)C labeled L-isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(6) Silac label Label:13C(6) MOD:01333 6x(13)C labeled L-isoleucine MOD:01333 A protein modification that effectively converts an L-isoleucine residue to 6x(13)C labeled L-isoleucine. PubMed:12716131 PubMed:12766232 Unimod:188#I DiffAvg: 6.02 DiffFormula: (12)C -6 (13)C 6 DiffMono: 6.020129 Formula: (13)C 6 H 11 N 1 O 1 MassAvg: 119.10 MassMono: 119.104193 Origin: I Source: artifact TermSpec: none Unimod: Unimod:188 13C(6) Silac label Label:13C(6) A protein modification that effectively converts an L-lysine residue to 6x(13)C labeled L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: lys-13c6 PSI-MOD 13C(6) Silac label Label:13C(6) MOD:01334 6x(13)C labeled L-lysine MOD:01334 A protein modification that effectively converts an L-lysine residue to 6x(13)C labeled L-lysine. OMSSA:138 PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:12716131 Unimod:188#K DiffAvg: 6.02 DiffFormula: (12)C -6 (13)C 6 DiffMono: 6.020129 Formula: (13)C 6 H 12 N 2 O 1 MassAvg: 134.12 MassMono: 134.115092 Origin: K Source: artifact TermSpec: none Unimod: Unimod:188 lys-13c6 13C(6) Silac label Label:13C(6) modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 4-sulfophenyl isothiocyanate (Heavy C13) SPITC:13C(6) MOD:01335 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized lysine MOD:01335 modification from Unimod Chemical derivative - PubMed:11467524 PubMed:16526082 Unimod:464#K DiffAvg: 220.99 DiffFormula: (12)C 1 (13)C 6 H 5 N 1 O 3 S 2 DiffMono: 220.991214 Formula: (12)C 7 (13)C 6 H 17 N 3 O 4 S 2 MassAvg: 349.09 MassMono: 349.086177 Origin: K Source: artifact TermSpec: none Unimod: Unimod:464 4-sulfophenyl isothiocyanate (Heavy C13) SPITC:13C(6) OBSOLETE - identical and redundant with MOD:00657. Remap to MOD:00657. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Deamidation followed by a methylation Methyl+Deamidated MOD:01336 Modification from Unimod Post-translational - Unimod:528. deamidation followed by a methylation -site Q true MOD:01336 OBSOLETE - identical and redundant with MOD:00657. Remap to MOD:00657. PubMed:18688235 DiffAvg: 15.01 DiffFormula: C 1 H 1 N -1 O 1 DiffMono: 14.999666 Formula: none MassAvg: none MassMono: none Origin: Q Remap: MOD:00657 Source: natural TermSpec: none Unimod: Unimod:528 Deamidation followed by a methylation Methyl+Deamidated A protein modification that effectively converts an L-asparagine residue to L-aspartate 4-methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Deamidation followed by a methylation Methyl+Deamidated MOD:01337 The deamidation and methylation of L-asparagine has not been reported as a natural modification. It is extremely unlikely that eukaryotes produce this modification, because a natural process that would form L-aspartic acid 4-methyl ester from either L-aspartic acid or L-asparagine would interfere with the D-aspartyl peptide repair mechanism [JSG]. deamidated 4-methyl esterified asparagine MOD:01337 A protein modification that effectively converts an L-asparagine residue to L-aspartate 4-methyl ester. Unimod:528#N DiffAvg: 15.01 DiffFormula: C 1 H 1 N -1 O 1 DiffMono: 14.999666 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: N Source: artifact TermSpec: none Unimod: Unimod:528 Deamidation followed by a methylation Methyl+Deamidated A protein modification that effectively converts an L-lysine residue to N6-ethyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Ethyl Ethylation MOD:01338 The Unimod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. N6-ethyl-L-lysine MOD:01338 A protein modification that effectively converts an L-lysine residue to N6-ethyl-L-lysine. PubMed:9629898 Unimod:280#K DiffAvg: 28.05 DiffFormula: C 2 H 4 DiffMono: 28.031300 Formula: C 8 H 16 N 2 O 1 MassAvg: 156.23 MassMono: 156.126263 Origin: K Source: hypothetical TermSpec: none Unimod: Unimod:280 Ethyl Ethylation A protein modification that effectively replaces a hydrogen atom with an ethyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: EtRes PSI-MOD Ethyl Ethylation MOD:01339 From DeltaMass: Average Mass: 28 with no citation. The Unimod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG]. ethylated residue MOD:01339 A protein modification that effectively replaces a hydrogen atom with an ethyl group. PubMed:9629898 Unimod:280 DiffAvg: 28.05 DiffFormula: C 2 H 4 DiffMono: 28.031300 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:280 EtRes Ethyl Ethylation modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD ESP-Tag heavy d10 ESP:2H(10) MOD:01340 ESP-Tag heavy d10 - site K MOD:01340 modification from Unimod Isotopic label - PubMed:11078590 PubMed:11085420 PubMed:11821862 Unimod:91#K DiffAvg: 348.24 DiffFormula: C 16 (1)H 16 (2)H 10 N 4 O 2 S 1 DiffMono: 348.240415 Formula: C 22 (1)H 28 (2)H 10 N 6 O 3 S 1 MassAvg: 476.34 MassMono: 476.335378 Origin: K Source: artifact TermSpec: none Unimod: Unimod:91 ESP-Tag heavy d10 ESP:2H(10) modification from Unimod Isotopic label - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD ESP ESP-Tag light d0 MOD:01341 ESP-Tag light d0 - site K MOD:01341 modification from Unimod Isotopic label - Unimod:90#K DiffAvg: 338.47 DiffFormula: C 16 H 26 N 4 O 2 S 1 DiffMono: 338.177647 Formula: C 22 H 38 N 6 O 3 S 1 MassAvg: 466.64 MassMono: 466.272610 Origin: K Source: artifact TermSpec: none Unimod: Unimod:90 ESP ESP-Tag light d0 OBSOLETE because redundant and identical to MOD:00530. Remap to MOD:00530. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Delta:S(-1)Se(1) Selenium replaces sulphur MOD:01342 selenium substitution for sulfur - site M true MOD:01342 OBSOLETE because redundant and identical to MOD:00530. Remap to MOD:00530. PubMed:12148805 Unimod:162 DiffAvg: 46.91 DiffFormula: S -1 Se 1 DiffMono: 47.944450 Formula: C 5 H 9 N 1 O 1 S 0 Se 1 MassAvg: 178.10 MassMono: 178.984935 Origin: M Remap: MOD:00530 Source: artifact TermSpec: none Unimod: Unimod:162 Delta:S(-1)Se(1) Selenium replaces sulphur OBSOLETE because redundant and identical to MOD:00686. Remap to MOD:00686. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD Delta:S(-1)Se(1) Selenium replaces sulphur MOD:01343 selenium substitution for sulfur - site C true MOD:01343 OBSOLETE because redundant and identical to MOD:00686. Remap to MOD:00686. PubMed:12148805 Unimod:162 DiffAvg: 46.91 DiffFormula: S -1 Se 1 DiffMono: 47.944450 Formula: C 3 H 5 N 1 O 1 S 0 Se 1 MassAvg: 150.05 MassMono: 150.953635 Origin: C Remap: MOD:00686 Source: artifact TermSpec: none Unimod: Unimod:162 Delta:S(-1)Se(1) Selenium replaces sulphur OBSOLETE because redundant and identical with MOD:00835. Remap to MOD:00835. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Unimod: PSI-MOD 2-amino-3-oxo-butanoic_acid Didehydro MOD:01344 dehydrogenated residue - site S true MOD:01344 OBSOLETE because redundant and identical with MOD:00835. Remap to MOD:00835. PubMed:9252331 PubMed:9276974 Unimod:401 DiffAvg: -2.02 DiffFormula: H -2 DiffMono: -2.015650 Formula: none MassAvg: none MassMono: none Origin: S Remap: MOD:00835 Source: natural TermSpec: none Unimod: Unimod:401 2-amino-3-oxo-butanoic_acid Didehydro A protein modification that effectively converts an L-threonine residue to 2-amino-3-oxobutanoic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 2-amino-3-ketobutyric acid 3-ketobutyrine twoamino3oxobutanoicacid PSI-MOD 2-amino-3-oxo-butanoic_acid Didehydro MOD:01345 There is no citation for this modification in the Unimod entry. Although mentioned in PubMed:9252331, there is no citation for it there [JSG]. 2-amino-3-oxobutanoic acid MOD:01345 A protein modification that effectively converts an L-threonine residue to 2-amino-3-oxobutanoic acid. OMSSA:23 PubMed:12716131 PubMed:9252331 Unimod:401#T DiffAvg: -2.02 DiffFormula: H -2 DiffMono: -2.015650 Formula: C 4 H 5 N 1 O 2 MassAvg: 99.09 MassMono: 99.032028 Origin: T Source: artifact TermSpec: none Unimod: Unimod:401 2-amino-3-ketobutyric acid 3-ketobutyrine twoamino3oxobutanoicacid 2-amino-3-oxo-butanoic_acid Didehydro A protein modification that effectively converts an L-asparagine residue to an N4-hexosyl-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex Hexose MOD:01346 N4-hexosylated asparagine MOD:01346 A protein modification that effectively converts an L-asparagine residue to an N4-hexosyl-L-asparagine. PubMed:11112526 PubMed:11567090 PubMed:15279557 PubMed:6540775 Unimod:41#N DiffAvg: 162.14 DiffFormula: C 6 H 10 O 5 DiffMono: 162.052823 Formula: C 10 H 16 N 2 O 7 MassAvg: 276.25 MassMono: 276.095751 Origin: N Source: natural TermSpec: none Unimod: Unimod:41 Hex Hexose A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and an L-lysine residue to form a Schiff-base or an Amadori ketosamine lysine adduct. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex Hexose MOD:01347 hexose glycated L-lysine MOD:01347 A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and an L-lysine residue to form a Schiff-base or an Amadori ketosamine lysine adduct. DeltaMass:0 PubMed:15279557 Unimod:41#K DiffAvg: 162.14 DiffFormula: C 6 H 10 O 5 DiffMono: 162.052823 Formula: C 12 H 22 N 2 O 6 MassAvg: 290.32 MassMono: 290.147786 Origin: K Source: natural TermSpec: none Unimod: Unimod:41 Hex Hexose A protein modification that effectively converts an L-threonine residue to an O-hexosyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex Hexose MOD:01348 O-hexosylated threonine MOD:01348 A protein modification that effectively converts an L-threonine residue to an O-hexosyl-L-threonine. PubMed:15279557 PubMed:8597590 Unimod:41#T DiffAvg: 162.14 DiffFormula: C 6 H 10 O 5 DiffMono: 162.052823 Formula: C 10 H 17 N 1 O 7 MassAvg: 263.25 MassMono: 263.100502 Origin: T Source: natural TermSpec: none Unimod: Unimod:41 Hex Hexose modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Nethylmaleimide+water Nethylmaleimidehydrolysis MOD:01349 Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(S-cysteinyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. hydrolyzed N-ethylmaleimide cysteine adduct MOD:01349 modification from Unimod Chemical derivative - Unimod:320#C DiffAvg: 143.14 DiffFormula: C 6 H 9 N 1 O 3 DiffMono: 143.058243 Formula: C 9 H 14 N 2 O 4 S 1 MassAvg: 246.28 MassMono: 246.067428 Origin: C Source: artifact TermSpec: none Unimod: Unimod:320 Nethylmaleimide+water Nethylmaleimidehydrolysis modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Nethylmaleimide+water Nethylmaleimidehydrolysis MOD:01350 Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(N6-lysyl)-4-(ethylamino)-4-oxobutanoic acid [JSG]. hydrolyzed N-ethylmaleimide lysine adduct MOD:01350 modification from Unimod Chemical derivative - Unimod:320#K DiffAvg: 143.14 DiffFormula: C 6 H 9 N 1 O 3 DiffMono: 143.058243 Formula: C 12 H 21 N 3 O 4 MassAvg: 271.32 MassMono: 271.153206 Origin: K Source: artifact TermSpec: none Unimod: Unimod:320 Nethylmaleimide+water Nethylmaleimidehydrolysis A protein modification that effectively converts an L-tryptophan residue to a nitrated L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: nitrow PSI-MOD Nitro Oxidation to nitro MOD:01351 One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. nitrated L-tryptophan MOD:01351 A protein modification that effectively converts an L-tryptophan residue to a nitrated L-tryptophan. OMSSA:85 PubMed:8839040 PubMed:9252331 Unimod:354#W DiffAvg: 45.00 DiffFormula: H -1 N 1 O 2 DiffMono: 44.985078 Formula: C 11 H 9 N 3 O 3 MassAvg: 231.21 MassMono: 231.064391 Origin: W Source: artifact TermSpec: none Unimod: Unimod:354 nitrow Nitro Oxidation to nitro A protein modification that effectively converts an L-tyrosine residue to a nitrated L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0213 nitroy PSI-MOD Nitro Oxidation to nitro MOD:01352 One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG]. nitrated L-tyrosine MOD:01352 A protein modification that effectively converts an L-tyrosine residue to a nitrated L-tyrosine. OMSSA:86 PubMed:14678012 PubMed:8839040 PubMed:9252331 Unimod:354#Y DiffAvg: 45.00 DiffFormula: H -1 N 1 O 2 DiffMono: 44.985078 Formula: C 9 H 8 N 2 O 4 MassAvg: 208.17 MassMono: 208.048407 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:354 nitroy Nitro Oxidation to nitro modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Amidine amidination of lysines or N-terminal amines with methyl acetimidate MOD:01353 amidination of lysines or N-terminal amines with methyl acetimidate - site K MOD:01353 modification from Unimod Chemical derivative - PubMed:12643539 PubMed:15602776 PubMed:6273432 Unimod:141#K DiffAvg: 41.05 DiffFormula: C 2 H 3 N 1 DiffMono: 41.026549 Formula: C 8 H 15 N 3 O 1 MassAvg: 169.23 MassMono: 169.121512 Origin: K Source: artifact TermSpec: none Unimod: Unimod:141 Amidine amidination of lysines or N-terminal amines with methyl acetimidate A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(1)NeuAc(1) Hex1HexNAc1NeuAc1 MOD:01354 Hex1HexNAc1NeuAc1 N4-glycosylated asparagine MOD:01354 A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. PubMed:11698400 Unimod:149#N DiffAvg: 657.60 DiffFormula: C 25 H 41 N 2 O 18 DiffMono: 657.235437 Formula: C 29 H 47 N 4 O 20 MassAvg: 771.70 MassMono: 771.278365 Origin: N Source: natural TermSpec: none Unimod: Unimod:149 Hex(1)HexNAc(1)NeuAc(1) Hex1HexNAc1NeuAc1 A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(1)NeuAc(1) Hex1HexNAc1NeuAc1 MOD:01355 Hex1HexNAc1NeuAc1 O-glycosylated threonine MOD:01355 A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. Unimod:149#T DiffAvg: 657.60 DiffFormula: C 25 H 41 N 2 O 18 DiffMono: 657.235437 Formula: C 29 H 48 N 3 O 20 MassAvg: 758.70 MassMono: 758.283116 Origin: T Source: natural TermSpec: none Unimod: Unimod:149 Hex(1)HexNAc(1)NeuAc(1) Hex1HexNAc1NeuAc1 A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Hex(1)HexNAc(1)NeuAc(1) Hex1HexNAc1NeuAc1 MOD:01356 Hex1HexNAc1NeuAc1 O-glycosylated serine MOD:01356 A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond. PubMed:7856876 Unimod:149#S DiffAvg: 657.60 DiffFormula: C 25 H 41 N 2 O 18 DiffMono: 657.235437 Formula: C 28 H 46 N 3 O 20 MassAvg: 744.68 MassMono: 744.267466 Origin: S Source: natural TermSpec: none Unimod: Unimod:149 Hex(1)HexNAc(1)NeuAc(1) Hex1HexNAc1NeuAc1 A protein modification that effectively replaces two hydrogen atoms of an L-lysine residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD DiMethyl-C13HD2 Dimethyl:2H(4)13C(2) MOD:01357 2x(13)C,4x(2)H labeled dimethylated L-lysine MOD:01357 A protein modification that effectively replaces two hydrogen atoms of an L-lysine residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-lysine. PubMed:12686488 PubMed:16335955 Unimod:510#K DiffAvg: 34.06 DiffFormula: (13)C 2 (2)H 4 DiffMono: 34.063117 Formula: (12)C 6 (13)C 2 (1)H 12 (2)H 4 N 2 O 1 MassAvg: 162.16 MassMono: 162.158080 Origin: K Source: artifact TermSpec: none Unimod: Unimod:510 DiMethyl-C13HD2 Dimethyl:2H(4)13C(2) modification from Unimod Isotopic label - Use when labelling post-digest DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form ICPL:2H(4) MOD:01358 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site N-term MOD:01358 modification from Unimod Isotopic label - Use when labelling post-digest PubMed:15602776 Unimod:687#N-term DiffAvg: 109.05 DiffFormula: C 6 (1)H -1 (2)H 4 N 1 O 1 DiffMono: 109.046571 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:687 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form ICPL:2H(4) modification from Unimod Isotopic label - Use when labelling post-digest DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form ICPL:2H(4) MOD:01359 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site K MOD:01359 modification from Unimod Isotopic label - Use when labelling post-digest PubMed:15602776 Unimod:687#K DiffAvg: 109.05 DiffFormula: C 6 (1)H -1 (2)H 4 N 1 O 1 DiffMono: 109.046571 Formula: C 12 (1)H 11 (2)H 4 N 3 O 2 MassAvg: 237.14 MassMono: 237.141534 Origin: K Source: artifact TermSpec: none Unimod: Unimod:687 Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form ICPL:2H(4) A protein modification that effectively converts an L-lysine residue to the 4-sulfophenyl isothiocyanate adduct, N6-[(4-sulfophenyl)carbamothioyl]lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N6-[(4-sulfophenyl)carbamothioyl]lysine PSI-MOD 4-sulfophenyl isothiocyanate SPITC MOD:01360 4-sulfophenyl isothiocyanate N6-derivatized lysine MOD:01360 A protein modification that effectively converts an L-lysine residue to the 4-sulfophenyl isothiocyanate adduct, N6-[(4-sulfophenyl)carbamothioyl]lysine. PubMed:14689565 PubMed:14745769 PubMed:15549660 PubMed:16526082 Unimod:261#K DiffAvg: 215.24 DiffFormula: C 7 H 5 N 1 O 3 S 2 DiffMono: 214.971085 Formula: C 13 H 17 N 3 O 4 S 2 MassAvg: 343.42 MassMono: 343.066048 Origin: K Source: artifact TermSpec: none Unimod: Unimod:261 N6-[(4-sulfophenyl)carbamothioyl]lysine 4-sulfophenyl isothiocyanate SPITC A protein modification that effectively converts an L-threonine residue to O-thiophospho-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Thiophospho Thiophosphorylation MOD:01361 O-thiophospho-L-threonine MOD:01361 A protein modification that effectively converts an L-threonine residue to O-thiophospho-L-threonine. PubMed:11507762 PubMed:12110917 Unimod:260#T DiffAvg: 96.04 DiffFormula: H 1 O 2 P 1 S 1 DiffMono: 95.943487 Formula: C 4 H 8 N 1 O 4 P 1 S 1 MassAvg: 197.14 MassMono: 196.991165 Origin: T Source: artifact TermSpec: none Unimod: Unimod:260 Thiophospho Thiophosphorylation A protein modification that effectively converts an L-serine residue to O-thiophospho-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Thiophospho Thiophosphorylation MOD:01362 O-thiophospho-L-serine MOD:01362 A protein modification that effectively converts an L-serine residue to O-thiophospho-L-serine. PubMed:11507762 PubMed:12110917 Unimod:260#S DiffAvg: 96.04 DiffFormula: H 1 O 2 P 1 S 1 DiffMono: 95.943487 Formula: C 3 H 6 N 1 O 4 P 1 S 1 MassAvg: 183.12 MassMono: 182.975515 Origin: S Source: artifact TermSpec: none Unimod: Unimod:260 Thiophospho Thiophosphorylation A protein modification that effectively converts an L-tyrosine residue to O4'-thiophospho-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Thiophospho Thiophosphorylation MOD:01363 O4'-thiophospho-L-tyrosine MOD:01363 A protein modification that effectively converts an L-tyrosine residue to O4'-thiophospho-L-tyrosine. PubMed:12110917 PubMed:15549660 Unimod:260#Y DiffAvg: 96.04 DiffFormula: H 1 O 2 P 1 S 1 DiffMono: 95.943487 Formula: C 9 H 10 N 1 O 4 P 1 S 1 MassAvg: 259.22 MassMono: 259.006815 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:260 Thiophospho Thiophosphorylation modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD FTC fluorescein-5-thiosemicarbazide MOD:01364 fluorescein-5-thiosemicarbazide - site S MOD:01364 modification from Unimod Chemical derivative - PubMed:11467524 Unimod:478#S DiffAvg: 421.43 DiffFormula: C 21 H 15 N 3 O 5 S 1 DiffMono: 421.073242 Formula: C 24 H 20 N 4 O 7 S 1 MassAvg: 508.51 MassMono: 508.105270 Origin: S Source: artifact TermSpec: none Unimod: Unimod:478 FTC fluorescein-5-thiosemicarbazide modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD FTC fluorescein-5-thiosemicarbazide MOD:01365 fluorescein-5-thiosemicarbazide - site C MOD:01365 modification from Unimod Chemical derivative - Unimod:478#C DiffAvg: 421.43 DiffFormula: C 21 H 15 N 3 O 5 S 1 DiffMono: 421.073242 Formula: C 24 H 20 N 4 O 6 S 2 MassAvg: 524.57 MassMono: 524.082426 Origin: C Source: artifact TermSpec: none Unimod: Unimod:478 FTC fluorescein-5-thiosemicarbazide modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD FTC fluorescein-5-thiosemicarbazide MOD:01366 fluorescein-5-thiosemicarbazide - site K MOD:01366 modification from Unimod Chemical derivative - Unimod:478#K DiffAvg: 421.43 DiffFormula: C 21 H 15 N 3 O 5 S 1 DiffMono: 421.073242 Formula: C 27 H 27 N 5 O 6 S 1 MassAvg: 549.60 MassMono: 549.168205 Origin: K Source: artifact TermSpec: none Unimod: Unimod:478 FTC fluorescein-5-thiosemicarbazide modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD FTC fluorescein-5-thiosemicarbazide MOD:01367 fluorescein-5-thiosemicarbazide - site P MOD:01367 modification from Unimod Chemical derivative - Unimod:478#P DiffAvg: 421.43 DiffFormula: C 21 H 15 N 3 O 5 S 1 DiffMono: 421.073242 Formula: C 26 H 22 N 4 O 6 S 1 MassAvg: 518.54 MassMono: 518.126005 Origin: P Source: artifact TermSpec: none Unimod: Unimod:478 FTC fluorescein-5-thiosemicarbazide modification from Unimod Chemical derivative - DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD FTC fluorescein-5-thiosemicarbazide MOD:01368 fluorescein-5-thiosemicarbazide - site R MOD:01368 modification from Unimod Chemical derivative - PubMed:15525938 Unimod:478#R DiffAvg: 421.43 DiffFormula: C 21 H 15 N 3 O 5 S 1 DiffMono: 421.073242 Formula: C 27 H 27 N 7 O 6 S 1 MassAvg: 577.62 MassMono: 577.174353 Origin: R Source: artifact TermSpec: none Unimod: Unimod:478 FTC fluorescein-5-thiosemicarbazide A protein modification that effectively replaces a carboxamido group with a carboxyl methyl ester group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Deamidation followed by a methylation Methyl+Deamidated MOD:01369 deamidated and methyl esterified residue MOD:01369 A protein modification that effectively replaces a carboxamido group with a carboxyl methyl ester group. Unimod:528 DiffAvg: 15.01 DiffFormula: C 1 H 1 N -1 O 1 DiffMono: 14.999666 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:528 Deamidation followed by a methylation Methyl+Deamidated A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C,1x(15)N labeled residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(6) 15N(1) Silac label Label:13C(6)15N(1) MOD:01370 6x(13)C,1x(15)N labeled residue MOD:01370 A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C,1x(15)N labeled residue. PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:695 DiffAvg: 7.02 DiffFormula: (12)C -6 (13)C 6 (14)N -1 (15)N 1 DiffMono: 7.017164 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:695 13C(6) 15N(1) Silac label Label:13C(6)15N(1) OBSOLETE bcecause identical and redundant with MOD:00851. Remap to MOD:00851. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD Deamidated:18O(1) Deamidation in presence of O18 MOD:01371 deamidation in presence of O18 true MOD:01371 OBSOLETE bcecause identical and redundant with MOD:00851. Remap to MOD:00851. PubMed:8382902 DiffAvg: 2.99 DiffFormula: H -1 N -1 (18)O 1 DiffMono: 2.988262 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00851 Source: artifact TermSpec: none Deamidated:18O(1) Deamidation in presence of O18 A protein modification that effectively converts an L-leucine residue to a (2S)-4-hydroxyleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0665 (2S)-2-amino-4-hydroxy-4-methylpentanoic acid (2S)-4-hydroxyleucine MOD_RES (2S)-4-hydroxyleucine gamma-hydroxyleucine PSI-MOD MOD:01372 (2S)-4-hydroxyleucine MOD:01372 A protein modification that effectively converts an L-leucine residue to a (2S)-4-hydroxyleucine. ChEBI:141825 PubMed:363352 PubMed:9164839 RESID:AA0442 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 11 N 1 O 2 MassAvg: 129.16 MassMono: 129.078979 Origin: L Source: natural TermSpec: none (2S)-2-amino-4-hydroxy-4-methylpentanoic acid (2S)-4-hydroxyleucine MOD_RES (2S)-4-hydroxyleucine gamma-hydroxyleucine A protein modification that effectively converts an L-leucine residue to a (2S,4R)-5-hydroxyleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0491 (2S,4R)-2-amino-5-hydroxy-4-methylpentanoic acid (2S,4R)-5-hydroxyleucine (4R)-5-hydroxyleucine MOD_RES (4R)-5-hydroxyleucine delta-hydroxyleucine PSI-MOD MOD:01373 (2S,4R)-5-hydroxyleucine MOD:01373 A protein modification that effectively converts an L-leucine residue to a (2S,4R)-5-hydroxyleucine. ChEBI:141824 PubMed:16858410 PubMed:7690768 PubMed:9164839 RESID:AA0443 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 11 N 1 O 2 MassAvg: 129.16 MassMono: 129.078979 Origin: L Source: hypothetical TermSpec: none (2S,4R)-2-amino-5-hydroxy-4-methylpentanoic acid (2S,4R)-5-hydroxyleucine (4R)-5-hydroxyleucine MOD_RES (4R)-5-hydroxyleucine delta-hydroxyleucine A modification that effectively oxygenates C5 of an L-leucine residue to form a (2S,4R)-5-oxoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0492 (2S,4R)-2-amino-4-methyl-5-oxopentanoic acid (2S,4R)-5-oxoleucine (4R)-5-oxo-L-leucine PSI-MOD MOD:01374 (2S,4R)-5-oxoleucine MOD:01374 A modification that effectively oxygenates C5 of an L-leucine residue to form a (2S,4R)-5-oxoleucine. ChEBI:43739 PubMed:16858410 RESID:AA0444 DiffAvg: 13.98 DiffFormula: C 0 H -2 N 0 O 1 DiffMono: 13.979265 Formula: C 6 H 9 N 1 O 2 MassAvg: 127.14 MassMono: 127.063329 Origin: L Source: hypothetical TermSpec: none (2S,4R)-2-amino-4-methyl-5-oxopentanoic acid (2S,4R)-5-oxoleucine (4R)-5-oxo-L-leucine A protein modification that effectively converts an L-leucine residue to a (2S,4R)-4,5-dihydroxyleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0340 (2S,4R)-2-amino-4,5-dihydroxy-4-methylpentanoic acid (2S,4R)-4,5-dihydroxyleucine (4R)-4,5-dihydroxyleucine MOD_RES (4R)-4,5-dihydroxyleucine gamma,delta-dihydroxyleucine PSI-MOD MOD:01375 (2S,4R)-4,5-dihydroxyleucine MOD:01375 A protein modification that effectively converts an L-leucine residue to a (2S,4R)-4,5-dihydroxyleucine. ChEBI:141823 PubMed:6010785 PubMed:6893271 RESID:AA0445 DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 6 H 11 N 1 O 3 MassAvg: 145.16 MassMono: 145.073893 Origin: L Source: natural TermSpec: none (2S,4R)-2-amino-4,5-dihydroxy-4-methylpentanoic acid (2S,4R)-4,5-dihydroxyleucine (4R)-4,5-dihydroxyleucine MOD_RES (4R)-4,5-dihydroxyleucine gamma,delta-dihydroxyleucine A protein modification that effectively converts an L-isoleucine residue to a (2S,3S,4R)-3,4-dihydroxyisoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0343 (2S,3S,4R)-2-amino-3,4-dihydroxy-3-methylpentanoic acid (2S,3S,4R)-3,4-dihydroxyisoleucine (3S,4R)-3,4-dihydroxyisoleucine MOD_RES (3S,4R)-3,4-dihydroxyisoleucine beta,gamma-dihydroxyisoleucine PSI-MOD MOD:01376 (2S,3S,4R)-3,4-dihydroxyisoleucine MOD:01376 A protein modification that effectively converts an L-isoleucine residue to a (2S,3S,4R)-3,4-dihydroxyisoleucine. ChEBI:141827 PubMed:11320328 RESID:AA0447 DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 6 H 11 N 1 O 3 MassAvg: 145.16 MassMono: 145.073893 Origin: I Source: natural TermSpec: none (2S,3S,4R)-2-amino-3,4-dihydroxy-3-methylpentanoic acid (2S,3S,4R)-3,4-dihydroxyisoleucine (3S,4R)-3,4-dihydroxyisoleucine MOD_RES (3S,4R)-3,4-dihydroxyisoleucine beta,gamma-dihydroxyisoleucine A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4S)-4-hydroxyisoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0337 (2S,3R,4S)-2-amino-3-methyl-4-hydroxyvaleric acid (2S,3R,4S)-2-amino-4-hydroxy-3-methylpentanoic acid (2S,3R,4S)-4-hydroxyisoleucine (3R,4S)-4-hydroxyisoleucine MOD_RES (3R,4S)-4-hydroxyisoleucine gamma-hydroxyisoleucine PSI-MOD MOD:01377 (2S,3R,4S)-4-hydroxyisoleucine MOD:01377 A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4S)-4-hydroxyisoleucine. ChEBI:141844 PubMed:363352 RESID:AA0448 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 11 N 1 O 2 MassAvg: 129.16 MassMono: 129.078979 Origin: I Source: natural TermSpec: none (2S,3R,4S)-2-amino-3-methyl-4-hydroxyvaleric acid (2S,3R,4S)-2-amino-4-hydroxy-3-methylpentanoic acid (2S,3R,4S)-4-hydroxyisoleucine (3R,4S)-4-hydroxyisoleucine MOD_RES (3R,4S)-4-hydroxyisoleucine gamma-hydroxyisoleucine A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4R)-4,5-dihydroxyisoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0336 (2S,3R,4R)-2-amino-4,5-dihydroxy-3-methylpentanoic acid (2S,3R,4R)-4,5-dihydroxyisoleucine (3R,4R)-4,5-dihydroxyisoleucine MOD_RES (3R,4R)-4,5-dihydroxyisoleucine gamma,delta-dihydroxyisoleucine PSI-MOD MOD:01378 (2S,3R,4R)-4,5-dihydroxyisoleucine MOD:01378 A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4R)-4,5-dihydroxyisoleucine. ChEBI:141826 PubMed:11805306 PubMed:18552824 PubMed:363352 RESID:AA0449 DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 6 H 11 N 1 O 3 MassAvg: 145.16 MassMono: 145.073893 Origin: I Source: natural TermSpec: none (2S,3R,4R)-2-amino-4,5-dihydroxy-3-methylpentanoic acid (2S,3R,4R)-4,5-dihydroxyisoleucine (3R,4R)-4,5-dihydroxyisoleucine MOD_RES (3R,4R)-4,5-dihydroxyisoleucine gamma,delta-dihydroxyisoleucine A protein modification that effectively converts an L-tryptophan residue to 2'-methylsulfonyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0304 2'-methylsulfonyl-L-tryptophan 2-methylsulfonyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole MOD_RES 2'-methylsulfonyltryptophan PSI-MOD MOD:01379 2'-methylsulfonyl-L-tryptophan MOD:01379 A protein modification that effectively converts an L-tryptophan residue to 2'-methylsulfonyl-L-tryptophan. PubMed:6893271 RESID:AA0450 DiffAvg: 78.09 DiffFormula: C 1 H 2 N 0 O 2 S 1 DiffMono: 77.977550 Formula: C 12 H 12 N 2 O 3 S 1 MassAvg: 264.30 MassMono: 264.056863 Origin: W Source: natural TermSpec: none 2'-methylsulfonyl-L-tryptophan 2-methylsulfonyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole MOD_RES 2'-methylsulfonyltryptophan A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0338 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide 2-((2R)-2-amino-2carboxyethyl)sulfinyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole 6'-hydroxy-S-oxo-tryptathionine CROSSLNK 2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys) PSI-MOD MOD:01380 Cross-link 2. 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide MOD:01380 A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide. PubMed:11805306 PubMed:18552824 PubMed:363352 PubMed:4865716 RESID:AA0451 DiffAvg: 29.98 DiffFormula: C 0 H -2 N 0 O 2 S 0 DiffMono: 29.974179 Formula: C 14 H 13 N 3 O 4 S 1 MassAvg: 319.33 MassMono: 319.062677 Origin: C, W Source: natural TermSpec: none 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide 2-((2R)-2-amino-2carboxyethyl)sulfinyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole 6'-hydroxy-S-oxo-tryptathionine CROSSLNK 2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys) A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0493 (2S)-2-amino-3-((9Z)-9-hexadecenoyloxy)propanoic acid L-serine cis-9-hexadecenoate ester LIPID O-palmitoleyl serine O-palmitoleyl-L-serine O3-palmitoleyl-serine mod186 PSI-MOD MOD:01381 O-palmitoleyl-L-serine MOD:01381 A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine. OMSSA:186 PubMed:17141155 RESID:AA0455 DiffAvg: 236.40 DiffFormula: C 16 H 28 N 0 O 1 DiffMono: 236.214016 Formula: C 19 H 33 N 1 O 3 MassAvg: 323.48 MassMono: 323.246044 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-((9Z)-9-hexadecenoyloxy)propanoic acid L-serine cis-9-hexadecenoate ester LIPID O-palmitoleyl serine O-palmitoleyl-L-serine O3-palmitoleyl-serine mod186 A protein modification that effectively converts an L-methionine residue to N,N,N-trimethyl-L-methionine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0503 (1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanaminium (1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanazanium 2-trimethylammonio-4-(methylthio)butanoic acid MOD_RES N,N,N-trimethylmethionine N,N,N-trimethyl-L-methionine N,N,N-trimethylmethionine cation N,N,N-trimethylmethioninium N2Me3+Met PSI-MOD MOD:01382 N,N,N-trimethyl-L-methionine MOD:01382 A protein modification that effectively converts an L-methionine residue to N,N,N-trimethyl-L-methionine. PubMed:18611379 RESID:AA0456 DiffAvg: 43.09 DiffFormula: C 3 H 7 N 0 O 0 S 0 DiffMono: 43.054227 FormalCharge: 1+ Formula: C 8 H 17 N 1 O 1 S 1 MassAvg: 175.29 MassMono: 175.102537 Origin: M Source: natural TermSpec: N-term (1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanaminium (1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanazanium 2-trimethylammonio-4-(methylthio)butanoic acid MOD_RES N,N,N-trimethylmethionine N,N,N-trimethyl-L-methionine N,N,N-trimethylmethionine cation N,N,N-trimethylmethioninium N2Me3+Met A protein modification that effectively cross-links two L-cysteine residues and oxidizes a sulfur to form L-cystine S-oxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0324 (2R)-2-amino-3-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)sulfinyl]propanoic acid CROSSLNK S-cysteinyl 3-(oxidosulfanyl)alanine (Cys-Cys) L-cystine S-oxide S-[(2R)-2-amino-3-oxopropyl] (2R)-2-amino-3-oxopropane-1-sulfinothioate S-cysteinyl 3-(oxidosulfanyl)alanine cystine sulfoxide PSI-MOD MOD:01383 Cross-link 2. L-cystine S-oxide MOD:01383 A protein modification that effectively cross-links two L-cysteine residues and oxidizes a sulfur to form L-cystine S-oxide. RESID:AA0457 DiffAvg: 13.98 DiffFormula: C 0 H -2 N 0 O 1 S 0 DiffMono: 13.979265 Formula: C 6 H 8 N 2 O 3 S 2 MassAvg: 220.26 MassMono: 219.997634 Origin: C, C Source: hypothetical TermSpec: none (2R)-2-amino-3-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)sulfinyl]propanoic acid CROSSLNK S-cysteinyl 3-(oxidosulfanyl)alanine (Cys-Cys) L-cystine S-oxide S-[(2R)-2-amino-3-oxopropyl] (2R)-2-amino-3-oxopropane-1-sulfinothioate S-cysteinyl 3-(oxidosulfanyl)alanine cystine sulfoxide A protein modification that effectively converts an L-serine residue to an aminomalonic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0321 2-carboxyglycine Ama MOD_RES Aminomalonic acid (Ser) aminomalonic acid aminopropanedioic acid PSI-MOD MOD:01384 aminomalonic acid (Ser) MOD:01384 A protein modification that effectively converts an L-serine residue to an aminomalonic acid. PubMed:1621954 PubMed:5415959 PubMed:6366787 PubMed:7457858 RESID:AA0458 DiffAvg: 13.98 DiffFormula: C 0 H -2 N 0 O 1 S 0 DiffMono: 13.979265 Formula: C 3 H 3 N 1 O 3 MassAvg: 101.06 MassMono: 101.011293 Origin: S Source: hypothetical TermSpec: none 2-carboxyglycine Ama MOD_RES Aminomalonic acid (Ser) aminomalonic acid aminopropanedioic acid A protein modification that effectively converts an L-phenylalanine residue to 3-hydroxy-L-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0346 (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid 3-hydoxyphenylalanine 3-hydroxy-L-phenylalanine 3-phenyl-L-serine 3HyPhe L-threo-3-phenylserine MOD_RES 3-hydroxyphenylalanine beta-hydroxyphenylalanine beta-phenylserine hydroxylationf PSI-MOD MOD:01385 3-hydroxy-L-phenylalanine MOD:01385 A protein modification that effectively converts an L-phenylalanine residue to 3-hydroxy-L-phenylalanine. ChEBI:16795 OMSSA:63 PubMed:10625477 PubMed:15651011 PubMed:16734421 PubMed:1880060 PubMed:7398618 PubMed:7844053 RESID:AA0462 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 9 H 9 N 1 O 2 MassAvg: 163.18 MassMono: 163.063329 Origin: F Source: natural TermSpec: none (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid 3-hydoxyphenylalanine 3-hydroxy-L-phenylalanine 3-phenyl-L-serine 3HyPhe L-threo-3-phenylserine MOD_RES 3-hydroxyphenylalanine beta-hydroxyphenylalanine beta-phenylserine hydroxylationf A protein modification that effectively converts an L-valine residue to 3-hydroxy-L-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0347 (2S)-2-amino-3-hydroxy-3-methylbutanoic acid 3-hydroxy-L-valine 3-hydroxyvaline 3HyVal MOD_RES 3-hydroxyvaline PSI-MOD MOD:01386 3-hydroxy-L-valine MOD:01386 A protein modification that effectively converts an L-valine residue to 3-hydroxy-L-valine. ChEBI:141793 PubMed:7328054 RESID:AA0463 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 5 H 9 N 1 O 2 MassAvg: 115.13 MassMono: 115.063329 Origin: V Source: natural TermSpec: none (2S)-2-amino-3-hydroxy-3-methylbutanoic acid 3-hydroxy-L-valine 3-hydroxyvaline 3HyVal MOD_RES 3-hydroxyvaline A protein modification that effectively converts an L-threonine residue to O-methyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0356 (2S,3R)-2-amino-3-methoxybutanoic acid MOD_RES O-methylthreonine O-methyl threonine O-methyl-L-threonine OMeThr threonine methyl ether PSI-MOD MOD:01387 O-methyl-L-threonine MOD:01387 A protein modification that effectively converts an L-threonine residue to O-methyl-L-threonine. PubMed:7328054 RESID:AA0464 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 5 H 9 N 1 O 2 MassAvg: 115.13 MassMono: 115.063329 Origin: T Source: natural TermSpec: none (2S,3R)-2-amino-3-methoxybutanoic acid MOD_RES O-methylthreonine O-methyl threonine O-methyl-L-threonine OMeThr threonine methyl ether A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanol. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0354 (2R)-1-aminopropan-2-ol 1-amino-2-hydroxypropane 1-amino-2-propanol 1-methyl-2-aminoethanol 2-amino-1-methylethanol 2-hydroxy-1-propylamine 2-hydroxypropanamine 2-hydroxypropylamine MOD_RES Decarboxylated threonine alpha-aminoisopropyl alcohol dCbxThr decarboxylated threonine isopropanolamine threamine PSI-MOD MOD:01388 1-amino-2-propanol MOD:01388 A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanol. ChEBI:15675 PubMed:7328054 RESID:AA0465 DiffAvg: -44.01 DiffFormula: C -1 H 0 N 0 O -2 DiffMono: -43.989829 Formula: C 3 H 8 N 1 O 1 MassAvg: 74.10 MassMono: 74.060589 Origin: T Source: natural TermSpec: C-term (2R)-1-aminopropan-2-ol 1-amino-2-hydroxypropane 1-amino-2-propanol 1-methyl-2-aminoethanol 2-amino-1-methylethanol 2-hydroxy-1-propylamine 2-hydroxypropanamine 2-hydroxypropylamine MOD_RES Decarboxylated threonine alpha-aminoisopropyl alcohol dCbxThr decarboxylated threonine isopropanolamine threamine A protein modification that effectively crosslinks an L-cysteine residue and an L-isoleucine residue to form L-isoleucine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0361 2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-thiazole-4-carboxylic acid 2-[1-zanyl-2-methylbutyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Ile-Cys) L-isoleucine thiazole-4-carboxylic acid PSI-MOD MOD:01389 Cross-link 2. L-isoleucine thiazole-4-carboxylic acid MOD:01389 A protein modification that effectively crosslinks an L-cysteine residue and an L-isoleucine residue to form L-isoleucine thiazole-4-carboxylic acid. PubMed:11320328 RESID:AA0466 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 9 H 12 N 2 O 1 S 1 MassAvg: 196.27 MassMono: 196.067034 Origin: C, I Source: natural TermSpec: none 2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-thiazole-4-carboxylic acid 2-[1-zanyl-2-methylbutyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Ile-Cys) L-isoleucine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue to form L-valine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0365 2-[(1S)-1-amino-2-methylpropyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-methylpropyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Val-Cys) L-valine thiazole-4-carboxylic acid PSI-MOD MOD:01390 Cross-link 2. L-valine thiazole-4-carboxylic acid MOD:01390 A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue to form L-valine thiazole-4-carboxylic acid. PubMed:7328054 RESID:AA0467 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 8 H 10 N 2 O 1 S 1 MassAvg: 182.24 MassMono: 182.051384 Origin: C, V Source: natural TermSpec: none 2-[(1S)-1-amino-2-methylpropyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-methylpropyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Val-Cys) L-valine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue, and C-5 methoxymethylates to form L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0373 2-[(1S)-1-amino-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid CROSSLNK 5-(methoxymethyl)thiazole-4-carboxylic acid (Val-Cys) L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid PSI-MOD MOD:01391 Cross-link 2. L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid MOD:01391 A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue, and C-5 methoxymethylates to form L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid. PubMed:10625477 PubMed:1880060 PubMed:7844053 RESID:AA0468 DiffAvg: 24.02 DiffFormula: C 2 H 0 N 0 O 0 S 0 DiffMono: 24.000000 Formula: C 10 H 14 N 2 O 2 S 1 MassAvg: 226.29 MassMono: 226.077599 Origin: C, V Source: natural TermSpec: none 2-[(1S)-1-amino-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid CROSSLNK 5-(methoxymethyl)thiazole-4-carboxylic acid (Val-Cys) L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue, and C-4 methylates to form L-asparagine 5-methylthiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0352 2-[(1S)-1,3-bisazanyl-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid 2-[(1S)-1,3-diamino-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid CROSSLNK 5-methylthiazole-4-carboxylic acid (Asn-Cys) L-asparagine 5-methylthiazole-4-carboxylic acid PSI-MOD MOD:01392 Cross-link 2. L-asparagine 5-methylthiazole-4-carboxylic acid MOD:01392 A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue, and C-4 methylates to form L-asparagine 5-methylthiazole-4-carboxylic acid. PubMed:10625477 PubMed:1880060 PubMed:7844053 RESID:AA0469 DiffAvg: -6.00 DiffFormula: C 1 H -2 N 0 O -1 S 0 DiffMono: -6.010565 Formula: C 8 H 9 N 3 O 2 S 1 MassAvg: 211.24 MassMono: 211.041548 Origin: C, N Source: natural TermSpec: none 2-[(1S)-1,3-bisazanyl-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid 2-[(1S)-1,3-diamino-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid CROSSLNK 5-methylthiazole-4-carboxylic acid (Asn-Cys) L-asparagine 5-methylthiazole-4-carboxylic acid A protein modification that crosslinks two serine residues and a cysteine residue by formation of a pyridine-2,5-dicarboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0358 6-[(1R)-1-amino-2-sulfanylethyl]pyridine-2,5-dicarboxylic acid L-cysteine pyridine-2,5-dicarboxylic acid PSI-MOD MOD:01393 Cross-link 3. L-cysteine pyridine-2,5-dicarboxylic acid MOD:01393 A protein modification that crosslinks two serine residues and a cysteine residue by formation of a pyridine-2,5-dicarboxylic acid. PubMed:10625477 PubMed:1880060 PubMed:7844053 RESID:AA0470 DiffAvg: -70.07 DiffFormula: C 0 H -8 N -1 O -3 S 0 DiffMono: -70.050418 Formula: C 9 H 7 N 2 O 2 S 1 MassAvg: 207.23 MassMono: 207.022823 Origin: C, S, S Source: natural TermSpec: none 6-[(1R)-1-amino-2-sulfanylethyl]pyridine-2,5-dicarboxylic acid L-cysteine pyridine-2,5-dicarboxylic acid A protein modification that crosslinks two serine residues and a cysteine residue by formation of a 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0348 (5R,6R)-5-amino-6-[(1R)-1-amino-2-sulfanylethyl]-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid L-cysteine 5-aminopiperideine-2,5-dicarboxylic acid PSI-MOD CROSSLNK 5-amino-piperideine-2,5-dicarboxylic acid MOD:01394 Cross-link 3. L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid MOD:01394 A protein modification that crosslinks two serine residues and a cysteine residue by formation of a 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid. PubMed:11320328 RESID:AA0471 DiffAvg: -53.04 DiffFormula: C 0 H -5 N 0 O -3 S 0 DiffMono: -53.023869 Formula: C 9 H 11 N 3 O 2 S 1 MassAvg: 225.27 MassMono: 225.057198 Origin: C, S, S Source: natural TermSpec: N-term (5R,6R)-5-amino-6-[(1R)-1-amino-2-sulfanylethyl]-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid L-cysteine 5-aminopiperideine-2,5-dicarboxylic acid CROSSLNK 5-amino-piperideine-2,5-dicarboxylic acid A protein modification that effectively results from forming an adduct between an isoleucine residue, a threonine residue and the quinaldate compound 2-carboxy-4-(1-hydroxyethyl)--7,8-dihydroquinolin-8-ol. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (7R,8S)-7-[(1S,2S)-1-carboxy-2-methylbutyl]amino-2-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)carbonyl-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7,8-dihydroquinoline 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol BINDING 4-(1-hydroxyethyl)-7,8-dihydroquinolin-8-ol (covalent; via 2 links) PSI-MOD MOD:01395 Cross-link 2. 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol MOD:01395 A protein modification that effectively results from forming an adduct between an isoleucine residue, a threonine residue and the quinaldate compound 2-carboxy-4-(1-hydroxyethyl)--7,8-dihydroquinolin-8-ol. PubMed:11320328 RESID:AA0472 DiffAvg: 215.21 DiffFormula: C 12 H 9 N 1 O 3 DiffMono: 215.058243 Formula: C 22 H 28 N 3 O 6 MassAvg: 430.48 MassMono: 430.197811 Origin: I, T Source: natural TermSpec: N-term (7R,8S)-7-[(1S,2S)-1-carboxy-2-methylbutyl]amino-2-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)carbonyl-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7,8-dihydroquinoline 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol BINDING 4-(1-hydroxyethyl)-7,8-dihydroquinolin-8-ol (covalent; via 2 links) A protein modification that effectively converts an L-proline residue to a 5-hydroxy-3-methyl-L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid 5-hydroxy-3-methyl-L-proline 5-hydroxy-3-methylproline 5Hy3MePro MOD_RES 5-hydroxy-3-methylproline (Ile) beta-methyl-delta-hydroxyproline PSI-MOD MOD:01396 This entry is for the hypothetical formation of 5-hydroxy-3-methyl-L-proline from proline. For the natural production from L-isoleucine, use MOD:01897 [JSG]. 5-hydroxy-3-methyl-L-proline (Pro) MOD:01396 A protein modification that effectively converts an L-proline residue to a 5-hydroxy-3-methyl-L-proline. PubMed:7592021 PubMed:8557573 RESID:AA0473 DiffAvg: 30.03 DiffFormula: C 1 H 2 N 0 O 1 DiffMono: 30.010565 Formula: C 6 H 9 N 1 O 2 MassAvg: 127.14 MassMono: 127.063329 Origin: P Source: artifactual TermSpec: none (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid 5-hydroxy-3-methyl-L-proline 5-hydroxy-3-methylproline 5Hy3MePro MOD_RES 5-hydroxy-3-methylproline (Ile) beta-methyl-delta-hydroxyproline A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0386 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid 2-[1-azanyl-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid CROSSLNK 5-methyloxazole-4-carboxylic acid (Ser-Thr) L-serine 5-methyloxazole-4-carboxylic acid PSI-MOD MOD:01397 Cross-link 2. L-serine 5-methyloxazole-4-carboxylic acid MOD:01397 A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazole-4-carboxylic acid. PubMed:7592021 PubMed:8557573 RESID:AA0474 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 DiffMono: -20.026215 Formula: C 7 H 8 N 2 O 3 MassAvg: 168.15 MassMono: 168.053492 Origin: S, T Source: natural TermSpec: none 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid 2-[1-azanyl-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid CROSSLNK 5-methyloxazole-4-carboxylic acid (Ser-Thr) L-serine 5-methyloxazole-4-carboxylic acid A protein modification that effectively converts an L-lysine residue to N6-propanoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0642 (2S)-2-amino-6-(propanoylamino)hexanoic acid 2-amino-6-propionylaminocaproic acid MOD_RES N6-propionyllysine N(zeta)-propanoyllysine N6-(1-oxopropyl)-L-lysine N6-propanoyl-L-lysine N6-propionyllysine epsilon-propanoyl-L-lysine epsilon-propionyl-L-lysine PSI-MOD MOD:01398 The binding of histone peptides with propanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. N6-propanoyl-L-lysine MOD:01398 A protein modification that effectively converts an L-lysine residue to N6-propanoyl-L-lysine. PubMed:17267393 PubMed:17684016 PubMed:20715035 RESID:AA0475 Unimod:58#K DiffAvg: 56.06 DiffFormula: C 3 H 4 N 0 O 1 DiffMono: 56.026215 Formula: C 9 H 16 N 2 O 2 MassAvg: 184.24 MassMono: 184.121178 Origin: K Source: natural TermSpec: none Unimod: Unimod:58 (2S)-2-amino-6-(propanoylamino)hexanoic acid 2-amino-6-propionylaminocaproic acid MOD_RES N6-propionyllysine N(zeta)-propanoyllysine N6-(1-oxopropyl)-L-lysine N6-propanoyl-L-lysine N6-propionyllysine epsilon-propanoyl-L-lysine epsilon-propionyl-L-lysine A protein modification that effectively converts an L-lysine residue to an N6-(ADP-ribosyl)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0355 (S)-2-amino-6-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)hexanoic acid 2-amino-6-(ADP-ribosyl)amino-hexanoic acid MOD_RES N6-(ADP-ribosyl)lysine N(zeta)-ADP-ribosyllysine N6-(ADP-ribosyl)-L-lysine N6-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-lysine N6-alpha-D-ribofuranosyl-L-lysine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) epsilon-ADP-ribosyllysine PSI-MOD MOD:01399 N6-(ADP-ribosyl)-L-lysine MOD:01399 A protein modification that effectively converts an L-lysine residue to an N6-(ADP-ribosyl)-L-lysine. PubMed:18436469 RESID:AA0476 DiffAvg: 541.30 DiffFormula: C 15 H 21 N 5 O 13 P 2 DiffMono: 541.061109 Formula: C 21 H 33 N 7 O 14 P 2 MassAvg: 669.48 MassMono: 669.156072 Origin: K Source: hypothetical TermSpec: none (S)-2-amino-6-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)hexanoic acid 2-amino-6-(ADP-ribosyl)amino-hexanoic acid MOD_RES N6-(ADP-ribosyl)lysine N(zeta)-ADP-ribosyllysine N6-(ADP-ribosyl)-L-lysine N6-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-lysine N6-alpha-D-ribofuranosyl-L-lysine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) epsilon-ADP-ribosyllysine A protein modification that effectively converts an L-lysine residue to an L-lysyl-poly(ADP-ribose). Origin: Source: TermSpec: L-lysyl-poly(ADP-ribose) MOD_RES Lysyl poly(ADP-ribose) poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl] (2S)-2,6-diaminohexanoate PSI-MOD MOD:01400 L-lysyl-poly(ADP-ribose) MOD:01400 A protein modification that effectively converts an L-lysine residue to an L-lysyl-poly(ADP-ribose). PubMed:6772638 RESID:AA0477 Origin: K Source: natural TermSpec: C-term L-lysyl-poly(ADP-ribose) MOD_RES Lysyl poly(ADP-ribose) poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl] (2S)-2,6-diaminohexanoate A protein modification that effectively converts an L-asparagine residue to a (2S,3S)-3-hydroxyasparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0370 (2S,3S)-2,4-diamino-3-hydroxy-4-oxobutanoic acid (2S,3S)-2-amino-3-hydroxy-4-butanediamic acid (2S,3S)-3-hydroxyasparagine (3S)3HyAsn L-threo-beta-hydroxyasparagine MOD_RES (3S)-3-hydroxyasparagine PSI-MOD MOD:01401 (2S,3S)-3-hydroxyasparagine MOD:01401 A protein modification that effectively converts an L-asparagine residue to a (2S,3S)-3-hydroxyasparagine. ChEBI:138107 ChEBI:50789 PubMed:11823643 PubMed:12042299 PubMed:12215170 PubMed:17573339 RESID:AA0478 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 4 H 6 N 2 O 3 MassAvg: 130.10 MassMono: 130.037842 Origin: N Source: natural TermSpec: none (2S,3S)-2,4-diamino-3-hydroxy-4-oxobutanoic acid (2S,3S)-2-amino-3-hydroxy-4-butanediamic acid (2S,3S)-3-hydroxyasparagine (3S)3HyAsn L-threo-beta-hydroxyasparagine MOD_RES (3S)-3-hydroxyasparagine A protein modification that effectively converts an L-proline residue to a (2S,3R,4R)-3,4-dihydroxyproline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0368 (2S,3R,4R)-3,4-dihydroxyproline (2S,3R,4R)-3,4-dihydroxypyrrolidine-2-carboxylic acid 2,3-trans-3,4-trans-3,4-dihydroxy-L-proline 2-alpha-3-beta-4-alpha-3,4-dihydroxyproline MOD_RES (3R,4R)-3,4-dihydroxyproline PSI-MOD MOD:01402 (2S,3R,4R)-3,4-dihydroxyproline MOD:01402 A protein modification that effectively converts an L-proline residue to a (2S,3R,4R)-3,4-dihydroxyproline. ChEBI:141805 PubMed:6893271 RESID:AA0479 DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: P Source: natural TermSpec: none (2S,3R,4R)-3,4-dihydroxyproline (2S,3R,4R)-3,4-dihydroxypyrrolidine-2-carboxylic acid 2,3-trans-3,4-trans-3,4-dihydroxy-L-proline 2-alpha-3-beta-4-alpha-3,4-dihydroxyproline MOD_RES (3R,4R)-3,4-dihydroxyproline A protein modification that effectively converts an L-leucine residue to a (2S)-4,5,5'-trihydroxyleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0372 (2S)-2-amino-4,5-dihydroxy-4-(hydroxymethyl)pentanoic acid (2S)-4,5,5'-trihydroxyleucine 4,5,5'-trihydroxyleucine MOD_RES 4,5,4'-trihydroxyleucine gamma,delta,delta'-trihydroxyleucine PSI-MOD MOD:01403 (2S)-4,5,5'-trihydroxyleucine MOD:01403 A protein modification that effectively converts an L-leucine residue to a (2S)-4,5,5'-trihydroxyleucine. PubMed:6893271 RESID:AA0480 DiffAvg: 48.00 DiffFormula: C 0 H 0 N 0 O 3 DiffMono: 47.984744 Formula: C 6 H 11 N 1 O 4 MassAvg: 161.16 MassMono: 161.068808 Origin: L Source: natural TermSpec: none (2S)-2-amino-4,5-dihydroxy-4-(hydroxymethyl)pentanoic acid (2S)-4,5,5'-trihydroxyleucine 4,5,5'-trihydroxyleucine MOD_RES 4,5,4'-trihydroxyleucine gamma,delta,delta'-trihydroxyleucine A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue to form L-asparagine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0359 2-[(1S)-1,3-diamino-3-oxopropyl]-1,3-thiazole-4-carboxylic acid 2-[1,3-bisazanyl-3-oxopropyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Asn-Cys) L-asparagine thiazole-4-carboxylic acid PSI-MOD MOD:01404 Cross-link 2. L-asparagine thiazole-4-carboxylic acid MOD:01404 A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue to form L-asparagine thiazole-4-carboxylic acid. PubMed:7592021 PubMed:8557573 RESID:AA0481 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 7 H 7 N 3 O 2 S 1 MassAvg: 197.21 MassMono: 197.025897 Origin: C, N Source: natural TermSpec: none 2-[(1S)-1,3-diamino-3-oxopropyl]-1,3-thiazole-4-carboxylic acid 2-[1,3-bisazanyl-3-oxopropyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Asn-Cys) L-asparagine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-proline residue to form L-proline thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-[(2S)-pyrrolidin-2-yl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Pro-Cys) L-proline thiazole-4-carboxylic acid PSI-MOD MOD:01405 Cross-link 2. L-proline thiazole-4-carboxylic acid MOD:01405 A protein modification that effectively crosslinks an L-cysteine residue and an L-proline residue to form L-proline thiazole-4-carboxylic acid. PubMed:7592021 PubMed:8557573 RESID:AA0482 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 8 H 8 N 2 O 1 S 1 MassAvg: 180.22 MassMono: 180.035734 Origin: C, P Source: natural TermSpec: none 2-[(2S)-pyrrolidin-2-yl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Pro-Cys) L-proline thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0364 2-[(1S,2R)-1-amino-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Thr-Cys) L-threonine thiazole-4-carboxylic acid PSI-MOD MOD:01406 Cross-link 2. L-threonine thiazole-4-carboxylic acid MOD:01406 A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazole-4-carboxylic acid. PubMed:11320328 RESID:AA0483 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 7 H 8 N 2 O 2 S 1 MassAvg: 184.21 MassMono: 184.030649 Origin: C, T Source: natural TermSpec: none 2-[(1S,2R)-1-amino-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Thr-Cys) L-threonine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazoline-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0366 (4R)-2-[(1S)-1-amino-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazoline-4-carboxylic acid (Phe-Cys) L-phenylalanine thiazoline-4-carboxylic acid PSI-MOD MOD:01407 Cross-link 2. L-phenylalanine thiazoline-4-carboxylic acid MOD:01407 A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazoline-4-carboxylic acid. PubMed:7592021 PubMed:8557573 RESID:AA0484 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 12 H 12 N 2 O 1 S 1 MassAvg: 232.30 MassMono: 232.067034 Origin: C, F Source: natural TermSpec: none (4R)-2-[(1S)-1-amino-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazoline-4-carboxylic acid (Phe-Cys) L-phenylalanine thiazoline-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazoline-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0392 (4S)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid CROSSLNK (4S)-thiazoline-4-carboxylic acid (Thr-Cys) L-threonine (4S)-thiazoline-4-carboxylic acid PSI-MOD MOD:01408 Cross-link 2. L-threonine thiazoline-4-carboxylic acid MOD:01408 A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazoline-4-carboxylic acid. PubMed:11320328 RESID:AA0485 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 7 H 10 N 2 O 2 S 1 MassAvg: 186.23 MassMono: 186.046299 Origin: C, T Source: natural TermSpec: none (4S)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid 2-[1-azanyl-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid CROSSLNK (4S)-thiazoline-4-carboxylic acid (Thr-Cys) L-threonine (4S)-thiazoline-4-carboxylic acid A protein modification that effectively replaces three hydrogen atoms with three hydroxyl groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Hy3Res PSI-MOD MOD:01409 trihydroxylated residue MOD:01409 A protein modification that effectively replaces three hydrogen atoms with three hydroxyl groups. PubMed:18688235 DiffAvg: 48.00 DiffFormula: C 0 H 0 N 0 O 3 DiffMono: 47.984744 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Hy3Res A protein modification that effectively converts an L-leucine residue to an hydroxylated leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: HyLeu PSI-MOD MOD:01410 hydroxylated leucine MOD:01410 A protein modification that effectively converts an L-leucine residue to an hydroxylated leucine. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: L Source: none TermSpec: none HyLeu A protein modification that effectively converts an L-leucine residue to a monohydroxylated leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Hy1Leu PSI-MOD MOD:01411 monohydroxylated leucine MOD:01411 A protein modification that effectively converts an L-leucine residue to a monohydroxylated leucine. PubMed:18688235 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 11 N 1 O 2 MassAvg: 129.16 MassMono: 129.078979 Origin: L Source: natural TermSpec: none Hy1Leu A protein modification that effectively converts an L-leucine residue to a dihydroxylated leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Hy2Leu PSI-MOD MOD:01412 dihydroxylated leucine MOD:01412 A protein modification that effectively converts an L-leucine residue to a dihydroxylated leucine. PubMed:18688235 DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 6 H 11 N 1 O 3 MassAvg: 145.16 MassMono: 145.073893 Origin: L Source: natural TermSpec: none Hy2Leu A protein modification that effectively converts an L-leucine residue to a trihydroxylated leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Hy3Leu PSI-MOD MOD:01413 trihydroxylated leucine MOD:01413 A protein modification that effectively converts an L-leucine residue to a trihydroxylated leucine. PubMed:18688235 DiffAvg: 48.00 DiffFormula: C 0 H 0 N 0 O 3 DiffMono: 47.984744 Formula: C 6 H 11 N 1 O 4 MassAvg: 161.16 MassMono: 161.068808 Origin: L Source: natural TermSpec: none Hy3Leu A protein modification that effectively converts an L-isoleucine residue to an hydroxylated isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: HyIle PSI-MOD MOD:01414 hydroxylated isoleucine MOD:01414 A protein modification that effectively converts an L-isoleucine residue to an hydroxylated isoleucine. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: I Source: none TermSpec: none HyIle A protein modification that effectively converts an L-isoleucine residue to a monohydroxylated isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Hy1Ile PSI-MOD MOD:01415 monohydroxylated isoleucine MOD:01415 A protein modification that effectively converts an L-isoleucine residue to a monohydroxylated isoleucine. PubMed:18688235 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 11 N 1 O 2 MassAvg: 129.16 MassMono: 129.078979 Origin: I Source: natural TermSpec: none Hy1Ile A protein modification that effectively converts an L-isoleucine residue to a dihydroxylated isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Hy2Ile PSI-MOD MOD:01416 dihydroxylated isoleucine MOD:01416 A protein modification that effectively converts an L-isoleucine residue to a dihydroxylated isoleucine. PubMed:18688235 DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 6 H 11 N 1 O 3 MassAvg: 145.16 MassMono: 145.073893 Origin: I Source: natural TermSpec: none Hy2Ile A protein modification that effectively converts an L-proline residue to a monomethylated proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Me1Pro PSI-MOD MOD:01417 monomethylated proline MOD:01417 A protein modification that effectively converts an L-proline residue to a monomethylated proline. PubMed:18688235 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 6 H 10 N 1 O 1 MassAvg: 112.15 MassMono: 112.076239 Origin: P Source: natural TermSpec: none Me1Pro A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: MeThr PSI-MOD MOD:01418 methylated threonine MOD:01418 A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: T Source: natural TermSpec: none MeThr A protein modification that crosslinks two residues by condensation of a serine or threonine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring, or by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid. PSI-MOD MOD:01419 oxazole/oxazoline ring crosslinked residues MOD:01419 A protein modification that crosslinks two residues by condensation of a serine or threonine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring, or by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid. PubMed:18688235 A protein modification that crosslinks two residues by condensation of a cysteine thiol with the carbonyl of the preceding residue to form a thiazole or thiazoline ring. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01420 thiazole/thiazoline ring crosslinked residues MOD:01420 A protein modification that crosslinks two residues by condensation of a cysteine thiol with the carbonyl of the preceding residue to form a thiazole or thiazoline ring. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Source: natural TermSpec: none A protein modification that crosslinks two residues by condensation of a serine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01421 oxazole/oxazoline ring crosslinked residues (Ser) MOD:01421 A protein modification that crosslinks two residues by condensation of a serine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: S Source: natural TermSpec: none A protein modification that crosslinks two residues by condensation of a threonine hydroxyl with the carbonyl of the preceding residue to form a 5-methyloxazole or 5-methyloxazoline ring. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01422 oxazole/oxazoline ring crosslinked residues (Thr) MOD:01422 A protein modification that crosslinks two residues by condensation of a threonine hydroxyl with the carbonyl of the preceding residue to form a 5-methyloxazole or 5-methyloxazoline ring. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: T Source: natural TermSpec: none A protein modification that effectively replaces a hydrogen atom with a palmitoleyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:01423 palmitoleylated residue MOD:01423 A protein modification that effectively replaces a hydrogen atom with a palmitoleyl group. Unimod:431 DiffAvg: 236.40 DiffFormula: C 16 H 28 N 0 O 1 DiffMono: 236.214016 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:431 A protein modification that effectively results from forming an adduct with a compound containing a quinaldate, kynurenate, or xanthurenate group. PSI-MOD MOD:01424 quinaldate modified residue MOD:01424 A protein modification that effectively results from forming an adduct with a compound containing a quinaldate, kynurenate, or xanthurenate group. PubMed:18688235 A protein modification that crosslinks three residues by formation of a pyridinyl ring, such as pyridine-2,5-dicarboxylic acid or 5-aminopiperideine-2,5-dicarboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01425 Cross-link 3. pyridinyl ring crosslinked residues MOD:01425 A protein modification that crosslinks three residues by formation of a pyridinyl ring, such as pyridine-2,5-dicarboxylic acid or 5-aminopiperideine-2,5-dicarboxylic acid. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that forms an adduct with a particular isotope labeled compound used as a reagent. PSI-MOD MOD:01426 isotope tagged reagent derivatized residue MOD:01426 A protein modification that forms an adduct with a particular isotope labeled compound used as a reagent. PubMed:18688235 OBSOLETE because redundant and identical to MOD:00819. Remap to MOD:00819. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: Abu PSI-MOD MOD:01427 2-aminobutanoic acid (Abu) true MOD:01427 OBSOLETE because redundant and identical to MOD:00819. Remap to MOD:00819. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 4 H 7 N 1 O 1 MassAvg: 85.11 MassMono: 85.052764 Origin: X Remap: MOD:00819 Source: artifact TermSpec: none Abu A protein modification that forms an adduct with a (13)C labeled compound used as a reagent. PSI-MOD MOD:01428 (13)C isotope tagged reagent MOD:01428 A protein modification that forms an adduct with a (13)C labeled compound used as a reagent. PubMed:18688235 A protein modification that forms an adduct with a (15)N labeled compound used as a reagent. PSI-MOD MOD:01429 (15)N isotope tagged reagent MOD:01429 A protein modification that forms an adduct with a (15)N labeled compound used as a reagent. PubMed:18688235 A protein modification that forms an adduct with a (13)C labeled compound used as a reagent. PSI-MOD MOD:01430 (18)O isotope tagged reagent MOD:01430 A protein modification that forms an adduct with a (13)C labeled compound used as a reagent. PubMed:18688235 A protein modification that forms an adduct with a (2)H labeled compound used as a reagent. PSI-MOD MOD:01431 (2)H deuterium tagged reagent MOD:01431 A protein modification that forms an adduct with a (2)H labeled compound used as a reagent. PubMed:18688235 A protein modification that effectively converts an L-leucine residue to a (2S,4S)-4,5-dihydroxyleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0666 (2S,4S)-2-amino-4,5-dihydroxy-4-methylpentanoic acid (2S,4S)-4,5-dihydroxyleucine (4S)-4,5-dihydroxyleucine MOD_RES (4S)-4,5-dihydroxyleucine gamma,delta-dihydroxyleucine PSI-MOD MOD:01432 (2S,4S)-4,5-dihydroxyleucine MOD:01432 A protein modification that effectively converts an L-leucine residue to a (2S,4S)-4,5-dihydroxyleucine. ChEBI:141819 PubMed:3718926 RESID:AA0446 DiffAvg: 32.00 DiffFormula: C 0 H 0 N 0 O 2 DiffMono: 31.989829 Formula: C 6 H 11 N 1 O 3 MassAvg: 145.16 MassMono: 145.073893 Origin: L Source: natural TermSpec: none (2S,4S)-2-amino-4,5-dihydroxy-4-methylpentanoic acid (2S,4S)-4,5-dihydroxyleucine (4S)-4,5-dihydroxyleucine MOD_RES (4S)-4,5-dihydroxyleucine gamma,delta-dihydroxyleucine A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0379 1-amino-2-propanone 1-aminopropan-2-one 1-aminopropanone MOD_RES 1-amino-2-propanone aminoacetone PSI-MOD MOD:01433 1-amino-2-propanone MOD:01433 A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanone. ChEBI:17906 PubMed:12715872 PubMed:19196969 RESID:AA0486 DiffAvg: -46.03 DiffFormula: C -1 H -2 N 0 O -2 DiffMono: -46.005479 Formula: C 3 H 6 N 1 O 1 MassAvg: 72.09 MassMono: 72.044939 Origin: T Source: natural TermSpec: C-term 1-amino-2-propanone 1-aminopropan-2-one 1-aminopropanone MOD_RES 1-amino-2-propanone aminoacetone A protein modification that effectively converts an L-glutamic acid residue to a 4-hydroxy-L-glutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0453 (2S,4Xi)-2-amino-4-hydroxypentanedioic acid 4-hydroxy-L-glutamic acid MOD_RES 4-hydroxyglutamate gamma-hydroxy glutaminic acid threo-4-hydroxy-L-glutamic acid PSI-MOD MOD:01434 4-hydroxy-L-glutamic acid MOD:01434 A protein modification that effectively converts an L-glutamic acid residue to a 4-hydroxy-L-glutamic acid. ChEBI:141845 PubMed:893891 RESID:AA0487 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 5 H 7 N 1 O 4 MassAvg: 145.11 MassMono: 145.037508 Origin: E Source: natural TermSpec: none (2S,4Xi)-2-amino-4-hydroxypentanedioic acid 4-hydroxy-L-glutamic acid MOD_RES 4-hydroxyglutamate gamma-hydroxy glutaminic acid threo-4-hydroxy-L-glutamic acid A protein modification that effectively results from forming an adduct between a cysteine residue, a glutamic acid residue and the indole compound 2-carboxy-3-methyl-4-hydroxymethyl--indole. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-([(1R)-1-amino-1-carboxyeth-2-yl]sulfanyl)carbonyl-3-methyl-4-([(1S)-1-amino-1-carboxy-4-oxobutan-4-yl]oxy)methyl-1H-indole 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole 2-(cystein-S-ylcarbonyl)-4-[(glutam-5-yloxy)methyl]-3-methyl-1H-indole BINDING 3-methyl-4-hydroxymethylindole-2-carboxylic acid (covalent; via 2 links) PSI-MOD MOD:01435 Cross-link 2. 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole MOD:01435 A protein modification that effectively results from forming an adduct between a cysteine residue, a glutamic acid residue and the indole compound 2-carboxy-3-methyl-4-hydroxymethyl--indole. PubMed:893891 RESID:AA0488 DiffAvg: 169.18 DiffFormula: C 11 H 7 N 1 O 1 S 0 DiffMono: 169.052764 Formula: C 19 H 19 N 3 O 5 S 1 MassAvg: 401.44 MassMono: 401.104542 Origin: C, E Source: natural TermSpec: none 2-([(1R)-1-amino-1-carboxyeth-2-yl]sulfanyl)carbonyl-3-methyl-4-([(1S)-1-amino-1-carboxy-4-oxobutan-4-yl]oxy)methyl-1H-indole 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole 2-(cystein-S-ylcarbonyl)-4-[(glutam-5-yloxy)methyl]-3-methyl-1H-indole BINDING 3-methyl-4-hydroxymethylindole-2-carboxylic acid (covalent; via 2 links) A protein modification that effectively converts an L-cysteine residue to cyclo[(prolylserin)-O-yl] cysteinate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate cyclo[(prolylserin)-O-yl] cysteinate PSI-MOD MOD:01436 cyclo[(prolylserin)-O-yl] cysteinate (Cys) MOD:01436 A protein modification that effectively converts an L-cysteine residue to cyclo[(prolylserin)-O-yl] cysteinate. PubMed:7961166 RESID:AA0489#CYS DiffAvg: 166.18 DiffFormula: C 8 H 10 N 2 O 2 S 0 DiffMono: 166.074228 Formula: C 11 H 16 N 3 O 4 S 1 MassAvg: 286.33 MassMono: 286.086152 Origin: C Source: natural TermSpec: C-term (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate cyclo[(prolylserin)-O-yl] cysteinate A protein modification that effectively converts an L-cysteine residue, an L-proline residue, and an L-serine residue to cyclo[(prolylserin)-O-yl] cysteinate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0380 (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate cyclo[(prolylserin)-O-yl] cysteinate PSI-MOD MOD:01437 Cross-link 3. cyclo[(prolylserin)-O-yl] cysteinate (Cys-Pro-Ser cross-link) MOD:01437 A protein modification that effectively converts an L-cysteine residue, an L-proline residue, and an L-serine residue to cyclo[(prolylserin)-O-yl] cysteinate. PubMed:7961166 RESID:AA0489#TRI DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 11 H 16 N 3 O 4 S 1 MassAvg: 286.33 MassMono: 286.086152 Origin: C, P, S Source: natural TermSpec: C-term (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate cyclo[(prolylserin)-O-yl] cysteinate A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-2-yl)ethyl]-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-PEC 2-vinylpyridine derivatized cysteine residue Pyridylethyl Cystenyl S-(pyridin-2-ylethyl)-L-cysteine PSI-MOD Pyridylethyl S-pyridylethylation MOD:01438 From DeltaMass: (name misspelled "Pyridylethyl Cystenyl", and formula incorrect, N and O reversed) Formula: C10H12O2N1S1 Monoisotopic Mass Change: 208.067 Average Mass Change: 208.286 S-[2-(pyridin-2-yl)ethyl]-L-cysteine MOD:01438 A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-2-yl)ethyl]-L-cysteine. PubMed:18369855 PubMed:18688235 DiffAvg: 105.14 DiffFormula: C 7 H 7 N 1 DiffMono: 105.057849 Formula: C 10 H 12 N 2 O 1 S 1 MassAvg: 208.28 MassMono: 208.067034 Origin: C Source: artifact TermSpec: none 2-PEC 2-vinylpyridine derivatized cysteine residue Pyridylethyl Cystenyl S-(pyridin-2-ylethyl)-L-cysteine Pyridylethyl S-pyridylethylation A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-4-yl)ethyl]-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-PEC Pyridylethyl Cystenyl S-(pyridin-4-ylethyl)-L-cysteine PSI-MOD Pyridylethyl S-pyridylethylation MOD:01439 S-[2-(pyridin-4-yl)ethyl]-L-cysteine MOD:01439 A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-4-yl)ethyl]-L-cysteine. PubMed:18688235 PubMed:6528972 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Source: artifact TermSpec: none 4-PEC Pyridylethyl Cystenyl S-(pyridin-4-ylethyl)-L-cysteine Pyridylethyl S-pyridylethylation A protein modification that effectively converts a source amino acid residue to an L-glutamyl semialdehyde. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-5-oxopentanoic acid L-glutamic gamma-semialdehyde PSI-MOD MOD:01440 glutamyl semialdehyde MOD:01440 A protein modification that effectively converts a source amino acid residue to an L-glutamyl semialdehyde. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 5 H 7 N 1 O 2 MassAvg: 113.12 MassMono: 113.047678 Origin: X Source: artifact TermSpec: none (S)-2-amino-5-oxopentanoic acid L-glutamic gamma-semialdehyde A protein modification that inserts or replaces a residue with a natural, standard, encoded residue. Origin: Source: TermSpec: PSI-MOD MOD:01441 natural, standard, encoded residue MOD:01441 A protein modification that inserts or replaces a residue with a natural, standard, encoded residue. PubMed:18688235 PubMed:6692818 Origin: X Source: natural TermSpec: none A protein modification that effectively cross-links an L-valine residue and an L-tyrosine residue by an ether bond to form 3-(O4'-L-tyrosyl)-L-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0390 (2S)-2-amino-3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-3-methylbutanoic acid 3-(O4'-L-tyrosyl)-L-valine CROSSLNK 3-(O4'-tyrosyl)-valine (Val-Tyr) PSI-MOD MOD:01442 Cross-link 2. 3-(O4'-L-tyrosyl)-L-valine MOD:01442 A protein modification that effectively cross-links an L-valine residue and an L-tyrosine residue by an ether bond to form 3-(O4'-L-tyrosyl)-L-valine. PubMed:19321420 RESID:AA0490 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 14 H 16 N 2 O 3 MassAvg: 260.29 MassMono: 260.116092 Origin: V, Y Source: natural TermSpec: none (2S)-2-amino-3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-3-methylbutanoic acid 3-(O4'-L-tyrosyl)-L-valine CROSSLNK 3-(O4'-tyrosyl)-valine (Val-Tyr) A protein modification that effectively converts four L-glutamic acid residues and two L-histidine residues to tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01443 Cross-link 6. It is not clear whether the lipid carboxylate is a cofactor or a substrate, and its identity is not certain. It was modeled as myristic acid [JSG]. tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide MOD:01443 A protein modification that effectively converts four L-glutamic acid residues and two L-histidine residues to tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide. PubMed:19321420 RESID:AA0491 DiffAvg: 350.12 DiffFormula: C 14 Fe 1 H 23 Mn 1 N 0 O 3 DiffMono: 350.038251 FormalCharge: 1- Formula: C 46 Fe 1 H 65 Mn 1 N 10 O 17 MassAvg: 1140.86 MassMono: 1140.326447 Origin: E, E, E, E, H, H Source: natural TermSpec: none A protein modification that effectively converts an L-cysteine residue to L-3,3-dihydroxyoalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-3,3-dihydroxypropanoic acid 2-(dihydroxymethyl)glycine 3,3-dihydroxy-L-alanine 3,3-dihydroxyalanine 3-hydroxy-L-serine 3-oxoalanine hydrate PSI-MOD C(alpha)-formylglycine hydrate MOD:01444 L-3,3-dihydroxyoalanine (Cys) MOD:01444 A protein modification that effectively converts an L-cysteine residue to L-3,3-dihydroxyoalanine. PubMed:11435113 PubMed:17558559 RESID:AA0492#CYS DiffAvg: -0.06 DiffFormula: C 0 H 0 N 0 O 2 S -1 DiffMono: 0.017758 Formula: C 3 H 5 N 1 O 3 MassAvg: 103.08 MassMono: 103.026943 Origin: C Source: natural TermSpec: none (S)-2-amino-3,3-dihydroxypropanoic acid 2-(dihydroxymethyl)glycine 3,3-dihydroxy-L-alanine 3,3-dihydroxyalanine 3-hydroxy-L-serine 3-oxoalanine hydrate C(alpha)-formylglycine hydrate A protein modification that effectively converts an L-serine residue to L-3,3-dihydroxyoalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-3,3-dihydroxypropanoic acid 2-(dihydroxymethyl)glycine 3,3-dihydroxy-L-alanine 3,3-dihydroxyalanine 3-hydroxy-L-serine 3-oxoalanine hydrate PSI-MOD C(alpha)-formylglycine hydrate MOD:01445 L-3,3-dihydroxyoalanine (Ser) MOD:01445 A protein modification that effectively converts an L-serine residue to L-3,3-dihydroxyoalanine. PubMed:11435113 PubMed:17558559 RESID:AA0492#SER DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 3 H 5 N 1 O 3 MassAvg: 103.08 MassMono: 103.026943 Origin: S Source: natural TermSpec: none (S)-2-amino-3,3-dihydroxypropanoic acid 2-(dihydroxymethyl)glycine 3,3-dihydroxy-L-alanine 3,3-dihydroxyalanine 3-hydroxy-L-serine 3-oxoalanine hydrate C(alpha)-formylglycine hydrate A protein modification that effectively converts an N-formyl-Lmethionine residue to N-(dihydroxymethyl)-L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid N-(dihydroxymethyl)-L-methionine N-formyl-L-methionine hydrate N-orthoformylmethionine PSI-MOD MOD:01446 N-(dihydroxymethyl)-L-methionine (fMet) MOD:01446 A protein modification that effectively converts an N-formyl-Lmethionine residue to N-(dihydroxymethyl)-L-methionine. PubMed:12595263 PubMed:9159480 RESID:AA0493 DiffAvg: 18.02 DiffFormula: C 0 H 2 N 0 O 1 S 0 DiffMono: 18.010565 Formula: C 6 H 12 N 1 O 3 S 1 MassAvg: 178.23 MassMono: 178.053789 Origin: MOD:00030 Source: hypothetical TermSpec: N-term (2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid N-(dihydroxymethyl)-L-methionine N-formyl-L-methionine hydrate N-orthoformylmethionine A protein modification that effectively converts an L-methionine residue to N-(dihydroxymethyl)-L-methionine (not known as a natural, post-translational modification process). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid N-(dihydroxymethyl)-L-methionine N-formyl-L-methionine hydrate N-orthoformylmethionine PSI-MOD MOD:01447 This entry is for the artifactual formation of N-(dihydroxymethyl)-L-methionine from methionine. For N-(dihydroxymethyl)-L-methionine derived from encoded N-formyl-L-methionine, use MOD:01446. N-(dihydroxymethyl)-L-methionine (Met) MOD:01447 A protein modification that effectively converts an L-methionine residue to N-(dihydroxymethyl)-L-methionine (not known as a natural, post-translational modification process). PubMed:12595263 PubMed:9159480 RESID:AA0493 DiffAvg: 46.03 DiffFormula: C 1 H 2 N 0 O 2 S 0 DiffMono: 46.005479 Formula: C 6 H 12 N 1 O 3 S 1 MassAvg: 178.23 MassMono: 178.053789 Origin: M Source: hypothetical TermSpec: N-term (2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid N-(dihydroxymethyl)-L-methionine N-formyl-L-methionine hydrate N-orthoformylmethionine A protein modification that effectively converts a source amino acid residue to L-3,3-dihydroxyoalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-3,3-dihydroxypropanoic acid 2-(dihydroxymethyl)glycine 3,3-dihydroxy-L-alanine 3,3-dihydroxyalanine 3-hydroxy-L-serine 3-oxoalanine hydrate PSI-MOD C(alpha)-formylglycine hydrate MOD:01448 L-3,3-dihydroxyoalanine MOD:01448 A protein modification that effectively converts a source amino acid residue to L-3,3-dihydroxyoalanine. PubMed:11435113 PubMed:17558559 RESID:AA0492 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 3 H 5 N 1 O 3 MassAvg: 103.08 MassMono: 103.026943 Origin: X Source: natural TermSpec: none (S)-2-amino-3,3-dihydroxypropanoic acid 2-(dihydroxymethyl)glycine 3,3-dihydroxy-L-alanine 3,3-dihydroxyalanine 3-hydroxy-L-serine 3-oxoalanine hydrate C(alpha)-formylglycine hydrate A protein modification that effectively converts an L-3-oxoalanine residue to L-3,3-dihydroxyoalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01449 L-3,3-dihydroxyoalanine (Oxoalanine) MOD:01449 A protein modification that effectively converts an L-3-oxoalanine residue to L-3,3-dihydroxyoalanine. PubMed:11435113 PubMed:17558559 PubMed:18688235 DiffAvg: 18.02 DiffFormula: C 0 H 2 N 0 O 1 DiffMono: 18.010565 Formula: C 3 H 5 N 1 O 3 MassAvg: 103.08 MassMono: 103.026943 Origin: MOD:01169 Source: natural TermSpec: none A protein modification that modifies an N-formyl-L-methionine residue. Origin: TermSpec: PSI-MOD MOD:01450 modified N-formyl-L-methionine residue MOD:01450 A protein modification that modifies an N-formyl-L-methionine residue. PubMed:18688235 Origin: MOD:00030 TermSpec: N-term A protein modification that converts an L-serine residue to O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01451 Phosphoserine is generated and detected after the facile elimination of pantetheine from the phosphopantetheine tertiary phosphodiester. See MOD:01452 for alternate origin. O-phospho-L-serine arising from O-phosphopantetheine-L-serine after neutral loss of pantetheine MOD:01451 A protein modification that converts an L-serine residue to O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine. PubMed:17042494 PubMed:18688235 DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 3 H 6 N 1 O 5 P 1 MassAvg: 167.06 MassMono: 166.998359 Origin: S Source: artifact TermSpec: none Covalent modification of a peptide or protein amino acid O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01452 Phosphoserine is generated and detected after the facile elimination of pantethiene from the phosphopantethiene tertiary phosphodiester. See MOD:01451 for alternate origin. O-phosphopantetheine-L-serine with neutral loss of pantetheine MOD:01452 Covalent modification of a peptide or protein amino acid O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine. PubMed:17042494 PubMed:18688235 DiffAvg: -260.35 DiffFormula: C -11 H -20 N -2 O -3 P 0 S -1 DiffMono: -260.119464 Formula: C 3 H 6 N 1 O 5 P 1 MassAvg: 167.06 MassMono: 166.998359 Origin: MOD:00159 Source: artifact TermSpec: none A protein modification that effectively converts a source amino acid residue to L-glutamate 5-methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-methoxy-5-oxopentanoic acid (5)-methyl L-hydrogen glutamate 2-aminopentanedioic acid 5-methyl ester 5-methyl L-2-aminoglutarate 5-methyl L-glutamate 5-methyl esterified L-glutamic acid L-glutamic acid 5-methyl ester O-methyl Glutamyl O5MeGlu glutamic acid 5-methyl ester glutamic acid gamma-methyl ester PSI-MOD MOD:01453 L-glutamic acid 5-methyl ester MOD:01453 A protein modification that effectively converts a source amino acid residue to L-glutamate 5-methyl ester. RESID:AA0072 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 6 H 9 N 1 O 3 MassAvg: 143.14 MassMono: 143.058243 Origin: X Source: natural TermSpec: none (2S)-2-amino-5-methoxy-5-oxopentanoic acid (5)-methyl L-hydrogen glutamate 2-aminopentanedioic acid 5-methyl ester 5-methyl L-2-aminoglutarate 5-methyl L-glutamate 5-methyl esterified L-glutamic acid L-glutamic acid 5-methyl ester O-methyl Glutamyl O5MeGlu glutamic acid 5-methyl ester glutamic acid gamma-methyl ester A protein modification that effectively crosslinks an N-terminal L-proline residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium. FormalCharge: Origin: Source: TermSpec: (1Z,2S)-2-carboxy-1-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]pyrrolidinium N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium PSI-MOD DNA glycosylase proline Schiff base intermediate MOD:01454 This linkage is not a Schiff-base [JSG]. N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium MOD:01454 A protein modification that effectively crosslinks an N-terminal L-proline residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium. PubMed:10833024 PubMed:11847126 PubMed:9030608 RESID:AA0494 FormalCharge: 1+ Origin: P Source: natural TermSpec: N-term (1Z,2S)-2-carboxy-1-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]pyrrolidinium N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium DNA glycosylase proline Schiff base intermediate A protein modification that effectively replaces a residue hydroxyl or carboxyl hydrogen with a phosphono group (H2PO3 or 'phosphate'). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: OPhosRes PSI-MOD MOD:01455 O-phosphorylated residue MOD:01455 A protein modification that effectively replaces a residue hydroxyl or carboxyl hydrogen with a phosphono group (H2PO3 or 'phosphate'). PubMed:18688235 DiffAvg: 79.98 DiffFormula: H 1 O 3 P 1 DiffMono: 79.966331 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none OPhosRes A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with a phosphono group (H2PO3 or 'phosphate'). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: NPhosRes PSI-MOD MOD:01456 N-phosphorylated residue MOD:01456 A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with a phosphono group (H2PO3 or 'phosphate'). PubMed:18688235 DiffAvg: 79.98 DiffFormula: H 1 O 3 P 1 DiffMono: 79.966331 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none NPhosRes A protein modification that effectively converts an L-serine residue to L-cysteine (not known as a natural, post-translational modification process). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Cys(Ser) PSI-MOD MOD:01457 L-cysteine (Ser) MOD:01457 A protein modification that effectively converts an L-serine residue to L-cysteine (not known as a natural, post-translational modification process). PubMed:1849824 PubMed:18688235 DiffAvg: -16.06 DiffFormula: C 0 H 0 N 0 O 1 S -1 DiffMono: -15.977156 Formula: C 3 H 5 N 1 O 1 S 1 MassAvg: 103.14 MassMono: 103.009185 Origin: C Source: artifact TermSpec: none Cys(Ser) A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acetyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N2AcRes ntermacetyl PSI-MOD MOD:01458 alpha-amino acetylated residue MOD:01458 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acetyl group. OMSSA:10 Unimod:1#N-term DiffAvg: 42.04 DiffFormula: C 2 H 2 N 0 O 1 DiffMono: 42.010565 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: N-term Unimod: Unimod:1 N2AcRes ntermacetyl A protein modification that effectively converts an N-terminal residue to an 4x(2)H labeled alpha-dimethylamino N-terminal residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: mod190 PSI-MOD DiMethyl-CHD2 Dimethyl:2H(4) MOD:01459 Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction. 4x(2)H labeled alpha-dimethylamino N-terminal residue MOD:01459 A protein modification that effectively converts an N-terminal residue to an 4x(2)H labeled alpha-dimethylamino N-terminal residue. OMSSA:190 PubMed:14670044 Unimod:199#N-term DiffAvg: 32.06 DiffFormula: C 2 (2)H 4 DiffMono: 32.056407 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:199 mod190 DiMethyl-CHD2 Dimethyl:2H(4) A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a methyl group. Origin: Source: TermSpec: N2MeRes PSI-MOD MOD:01460 alpha-amino methylated residue MOD:01460 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a methyl group. PubMed:18688235 Origin: X Source: natural TermSpec: N-term N2MeRes A protein modification that effectively replaces an L-alanine alpha amino hydrogen with a methyl group. Origin: Source: TermSpec: PSI-MOD MOD:01461 N-methylated alanine MOD:01461 A protein modification that effectively replaces an L-alanine alpha amino hydrogen with a methyl group. PubMed:18688235 Origin: A Source: natural TermSpec: none A protein modification that effectively replaces an L-proline alpha imino hydrogen with a methyl group. Origin: Source: TermSpec: PSI-MOD MOD:01462 N-methylated proline MOD:01462 A protein modification that effectively replaces an L-proline alpha imino hydrogen with a methyl group. PubMed:18688235 Origin: P Source: natural TermSpec: N-term A protein modification that effectively replaces an L-methionine alpha amino hydrogen with a methyl group. Origin: Source: TermSpec: PSI-MOD MOD:01463 N-methylated methionine MOD:01463 A protein modification that effectively replaces an L-methionine alpha amino hydrogen with a methyl group. PubMed:18688235 Origin: M Source: natural TermSpec: N-term A protein modification that effectively converts an L-methionine residue to an L-methioninium (protonated L-methionine). DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01464 protonated L-methionine (L-methioninium) residue MOD:01464 A protein modification that effectively converts an L-methionine residue to an L-methioninium (protonated L-methionine). PubMed:18688235 DiffAvg: 1.01 DiffFormula: C 0 H 1 N 0 O 0 S 0 DiffMono: 1.007276 FormalCharge: 1+ Formula: C 5 H 11 N 1 O 1 S 1 MassAvg: 133.21 MassMono: 133.055586 Origin: M Source: natural TermSpec: N-term A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to an N6,N6,N6-trimethyl-L-methionine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N2Me3Met PSI-MOD MOD:01465 For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Met process (MOD:01382) accounts for both protonation and trimethylation. N,N,N-trimethyl-L-methionine (from L-methioninium) MOD:01465 A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to an N6,N6,N6-trimethyl-L-methionine. PubMed:18688235 DiffAvg: 42.08 DiffFormula: C 3 H 6 N 0 O 0 S 0 DiffMono: 42.046402 FormalCharge: 1+ Formula: C 8 H 17 N 1 O 1 S 1 MassAvg: 175.29 MassMono: 175.102537 Origin: MOD:001464 Source: natural TermSpec: N-term N2Me3Met modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Menadione Menadione quinone derivative MOD:01466 menadione quinone derivative - site C MOD:01466 modification from Unimod Chemical derivative PubMed:15939799 Unimod:302#K DiffAvg: 170.17 DiffFormula: C 11 H 6 O 2 DiffMono: 170.036779 Formula: C 14 H 11 N 1 O 3 S 1 MassAvg: 273.31 MassMono: 273.045964 Origin: C Source: artifact TermSpec: none Unimod: Unimod:302 Menadione Menadione quinone derivative modification from Unimod Chemical derivative DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Menadione Menadione quinone derivative MOD:01467 menadione quinone derivative - site K MOD:01467 modification from Unimod Chemical derivative PubMed:15939799 Unimod:302#K DiffAvg: 170.17 DiffFormula: C 11 H 6 O 2 DiffMono: 170.036779 Formula: C 17 H 18 N 2 O 3 MassAvg: 298.34 MassMono: 298.131742 Origin: K Source: artifact TermSpec: none Unimod: Unimod:302 Menadione Menadione quinone derivative A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-selenocysteinyl-Se-molybdenum formate dehydrogenase selenocysteine molybdenum cofactor PSI-MOD L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) MolybdopterinGD+Delta:S(-1)Se(1) molybdopterin-se MOD:01468 This entry is for the artifactual formation of L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00253. L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Cys) MOD:01468 A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process). PubMed:14235557 PubMed:2211698 PubMed:8052647 PubMed:9036855 RESID:AA0248#CYS Unimod:415 DiffAvg: 1618.93 DiffFormula: C 40 H 47 Mo 1 N 20 O 26 P 4 S 3 Se 1 DiffMono: 1620.930226 Formula: C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1 MassAvg: 1722.07 MassMono: 1723.939410 Origin: C Source: artifact TermSpec: none Unimod: Unimod:415 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-selenocysteinyl-Se-molybdenum formate dehydrogenase selenocysteine molybdenum cofactor L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) MolybdopterinGD+Delta:S(-1)Se(1) molybdopterin-se A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01469 This entry is for the artifactual formation of L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00381. L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Cys) MOD:01469 A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process). PubMed:11372198 PubMed:12220497 RESID:AA0376#CYS DiffAvg: 1738.88 DiffFormula: C 40 H 47 N 20 O 26 P 4 S 4 Se 1 W 1 DiffMono: 1738.947820 Formula: C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1 MassAvg: 1842.02 MassMono: 1841.957004 Origin: C Source: artifact TermSpec: none A protein modification that effectively converts an L-threonine residue to (E)-dehydrobutyrine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0441 (2E)-2-aminobut-2-enoic acid (E)-2-amino-2-butenoic acid (E)-2-aminobutenoic acid (E)-dehydrobutyrine (E)dHAbu 2,3-didehydrobutyrine 3-methyldehydroalanine Dehydroamino butyric acid Dhb MOD_RES (E)-2,3-didehydrobutyrine alpha,beta-dehydroaminobutyric acid anhydrothreonine methyl-dehydroalanine PSI-MOD Dehydrated Dehydration MOD:01470 (E)-dehydrobutyrine (Thr) MOD:01470 A protein modification that effectively converts an L-threonine residue to (E)-dehydrobutyrine. DeltaMass:0 PubMed:1547888 PubMed:20805503 PubMed:3769923 RESID:AA0547 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 4 H 5 N 1 O 1 MassAvg: 83.09 MassMono: 83.037114 Origin: T Source: natural TermSpec: none (2E)-2-aminobut-2-enoic acid (E)-2-amino-2-butenoic acid (E)-2-aminobutenoic acid (E)-dehydrobutyrine (E)dHAbu 2,3-didehydrobutyrine 3-methyldehydroalanine Dehydroamino butyric acid Dhb MOD_RES (E)-2,3-didehydrobutyrine alpha,beta-dehydroaminobutyric acid anhydrothreonine methyl-dehydroalanine Dehydrated Dehydration A protein modification that effectively converts an L-threonine residue to (Z)-dehydrobutyrine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0440 (2Z)-2-aminobut-2-enoic acid (Z)-2-amino-2-butenoic acid (Z)-2-aminobutenoic acid (Z)-dehydrobutyrine (Z)dHAbu 2,3-didehydrobutyrine 3-methyldehydroalanine Dehydroamino butyric acid Dhb MOD_RES (Z)-2,3-didehydrobutyrine alpha,beta-dehydroaminobutyric acid anhydrothreonine methyl-dehydroalanine PSI-MOD Dehydrated Dehydration MOD:01471 (Z)-dehydrobutyrine (Thr) MOD:01471 A protein modification that effectively converts an L-threonine residue to (Z)-dehydrobutyrine. DeltaMass:0 PubMed:1547888 PubMed:3769923 RESID:AA0182 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 4 H 5 N 1 O 1 MassAvg: 83.09 MassMono: 83.037114 Origin: T Source: natural TermSpec: none (2Z)-2-aminobut-2-enoic acid (Z)-2-amino-2-butenoic acid (Z)-2-aminobutenoic acid (Z)-dehydrobutyrine (Z)dHAbu 2,3-didehydrobutyrine 3-methyldehydroalanine Dehydroamino butyric acid Dhb MOD_RES (Z)-2,3-didehydrobutyrine alpha,beta-dehydroaminobutyric acid anhydrothreonine methyl-dehydroalanine Dehydrated Dehydration A protein modification that effectively either adds neutral hydrogen atoms (proton and electron), or removes oxygen atoms from a residue with or without the addition of hydrogen atoms. RedRes PSI-MOD MOD:01472 reduced residue MOD:01472 A protein modification that effectively either adds neutral hydrogen atoms (proton and electron), or removes oxygen atoms from a residue with or without the addition of hydrogen atoms. PubMed:18688235 RedRes A protein modification that effectively adds neutral hydrogen atoms (proton and electron) to a residue. HRes PSI-MOD MOD:01473 hydrogenated residue MOD:01473 A protein modification that effectively adds neutral hydrogen atoms (proton and electron) to a residue. PubMed:18688235 HRes A protein modification that effectively converts an L-serine residue to O-[S-(carboxymethyl)phosphopantetheine]-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01474 This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetic acid [JSG]. O-[S-(carboxymethyl)phosphopantetheine]-L-serine MOD:01474 A protein modification that effectively converts an L-serine residue to O-[S-(carboxymethyl)phosphopantetheine]-L-serine. PubMed:18688235 DiffAvg: 398.37 DiffFormula: C 13 H 23 N 2 O 8 P 1 S 1 DiffMono: 398.091273 Formula: C 16 H 28 N 3 O 10 P 1 S 1 MassAvg: 485.44 MassMono: 485.123302 Origin: S Source: artifact TermSpec: none A protein modification that effectively converts an L-serine residue to O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01475 This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetamide [JSG]. O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine MOD:01475 A protein modification that effectively converts an L-serine residue to O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine. PubMed:18688235 DiffAvg: 397.38 DiffFormula: C 13 H 24 N 3 O 7 P 1 S 1 DiffMono: 397.107258 Formula: C 16 H 29 N 4 O 9 P 1 S 1 MassAvg: 484.46 MassMono: 484.139286 Origin: S Source: artifact TermSpec: none A protein modification that effectively converts an L-phenylalanine residue to an 2'-fluoro-L-fluorophenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-fluorophenylalanine o-fluorophenylalanine ortho-fluorophenylalanine PSI-MOD MOD:01476 2'-fluoro-L-phenylalanine MOD:01476 A protein modification that effectively converts an L-phenylalanine residue to an 2'-fluoro-L-fluorophenylalanine. PubMed:18688235 PubMed:8172898 DiffAvg: 17.99 DiffFormula: C 0 F 1 H -1 N 0 O 0 DiffMono: 17.990578 Formula: C 9 F 1 H 8 N 1 O 1 MassAvg: 165.17 MassMono: 165.058992 Origin: F Source: artifact TermSpec: none 2-fluorophenylalanine o-fluorophenylalanine ortho-fluorophenylalanine A protein modification that effectively converts an L-phenylalanine residue to an 3'-fluoro-L-fluorophenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-fluorophenylalanine m-fluorophenylalanine meta-fluorophenylalanine PSI-MOD MOD:01477 3'-fluoro-L-phenylalanine MOD:01477 A protein modification that effectively converts an L-phenylalanine residue to an 3'-fluoro-L-fluorophenylalanine. PubMed:18688235 PubMed:8172898 DiffAvg: 17.99 DiffFormula: C 0 F 1 H -1 N 0 O 0 DiffMono: 17.990578 Formula: C 9 F 1 H 8 N 1 O 1 MassAvg: 165.17 MassMono: 165.058992 Origin: F Source: artifact TermSpec: none 3-fluorophenylalanine m-fluorophenylalanine meta-fluorophenylalanine A protein modification that effectively converts an L-phenylalanine residue into an 4'-fluoro-L-fluorophenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-fluorophenylalanine p-fluorophenylalanine para-fluorophenylalanine rho-fluorophenylalanine PSI-MOD MOD:01478 4'-fluoro-L-phenylalanine MOD:01478 A protein modification that effectively converts an L-phenylalanine residue into an 4'-fluoro-L-fluorophenylalanine. PubMed:18688235 PubMed:8172898 DiffAvg: 17.99 DiffFormula: C 0 F 1 H -1 N 0 O 0 DiffMono: 17.990578 Formula: C 9 F 1 H 8 N 1 O 1 MassAvg: 165.17 MassMono: 165.058992 Origin: F Source: artifact TermSpec: none 4-fluorophenylalanine p-fluorophenylalanine para-fluorophenylalanine rho-fluorophenylalanine A protein modification that effectively converts an L-tryptophan residue into an 4'-fluoro-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-fluorotryptophan PSI-MOD MOD:01479 4'-fluoro-L-tryptophan MOD:01479 A protein modification that effectively converts an L-tryptophan residue into an 4'-fluoro-L-tryptophan. PubMed:18688235 PubMed:8172898 DiffAvg: 17.99 DiffFormula: F 1 H -1 DiffMono: 17.990578 Formula: C 11 F 1 H 9 N 2 O 1 MassAvg: 204.20 MassMono: 204.069891 Origin: W Source: artifact TermSpec: none 4-fluorotryptophan A protein modification that effectively converts an L-tryptophan residue into an 5'-fluoro-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 5-fluorotryptophan PSI-MOD MOD:01480 5'-fluoro-L-tryptophan MOD:01480 A protein modification that effectively converts an L-tryptophan residue into an 5'-fluoro-L-tryptophan. PubMed:18688235 PubMed:8172898 DiffAvg: 17.99 DiffFormula: F 1 H -1 DiffMono: 17.990578 Formula: C 11 F 1 H 9 N 2 O 1 MassAvg: 204.20 MassMono: 204.069891 Origin: W Source: artifact TermSpec: none 5-fluorotryptophan A protein modification that effectively converts an L-tryptophan residue into an 6'-fluoro-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 6-fluorotryptophan PSI-MOD MOD:01481 6'-fluoro-L-tryptophan MOD:01481 A protein modification that effectively converts an L-tryptophan residue into an 6'-fluoro-L-tryptophan. PubMed:18688235 PubMed:8172898 DiffAvg: 17.99 DiffFormula: F 1 H -1 DiffMono: 17.990578 Formula: C 11 F 1 H 9 N 2 O 1 MassAvg: 204.20 MassMono: 204.069891 Origin: W Source: artifact TermSpec: none 6-fluorotryptophan A protein modification that effectively substitutes a calcium atom or a cluster containing calcium for hydrogen atoms, or that coordinates a calcium ion. CaRes PSI-MOD MOD:01482 calcium containing modified residue MOD:01482 A protein modification that effectively substitutes a calcium atom or a cluster containing calcium for hydrogen atoms, or that coordinates a calcium ion. PubMed:18688235 CaRes A protein modification that effectively replaces a residue hydroxyl group with a formyloxy group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: OFoRes PSI-MOD MOD:01483 O-formylated residue MOD:01483 A protein modification that effectively replaces a residue hydroxyl group with a formyloxy group. PubMed:18688235 DiffAvg: 28.01 DiffFormula: C 1 O 1 DiffMono: 27.994915 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none OFoRes A protein modification that effectively crosslinks an L-glutamic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine and the release of water. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid 5-glutamyl N6-lysine N alpha -(gamma-Glutamyl)-lysine N(epsilon)-(gamma-glutamyl)lysine N6-(L-isoglutamyl)-L-lysine PSI-MOD MOD:01484 Cross-link 2. This cross-link is usually made by glutamine and releases ammonia, rather than glutamic acid and requiring the consumption of ATP. N6-(L-isoglutamyl)-L-lysine (Glu) MOD:01484 A protein modification that effectively crosslinks an L-glutamic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine and the release of water. ChEBI:21863 PubMed:19015515 RESID:AA0124#GLU DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 11 H 17 N 3 O 3 MassAvg: 239.27 MassMono: 239.126991 Origin: K, E Source: natural TermSpec: none (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid 5-glutamyl N6-lysine N alpha -(gamma-Glutamyl)-lysine N(epsilon)-(gamma-glutamyl)lysine N6-(L-isoglutamyl)-L-lysine A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 114 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ114 iTRAQ4plex114 MOD:01485 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-114 reporter+balance reagent acylated residue MOD:01485 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. Unimod:532 DiffAvg: 144.11 DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono: 144.105919 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:532 (4-methylpiperazin-1-yl)acetyl Accurate mass for 114 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ114 iTRAQ4plex114 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ114nterm PSI-MOD Accurate mass for 114 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ114 iTRAQ4plex114 MOD:01486 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-114 reporter+balance reagent acylated N-terminal MOD:01486 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. OMSSA:167 Unimod:532#N-term DiffAvg: 144.11 DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono: 144.105919 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:532 (4-methylpiperazin-1-yl)acetyl iTRAQ114nterm Accurate mass for 114 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ114 iTRAQ4plex114 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ114K PSI-MOD Accurate mass for 114 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ114 iTRAQ4plex114 MOD:01487 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-114 reporter+balance reagent N6-acylated lysine MOD:01487 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. OMSSA:168 Unimod:532#K DiffAvg: 144.11 DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono: 144.105919 Formula: (12)C 11 (13)C 2 H 24 N 4 (16)O 1 (18)O 1 MassAvg: 272.20 MassMono: 272.200882 Origin: K Source: artifact TermSpec: none Unimod: Unimod:532 (4-methylpiperazin-1-yl)acetyl iTRAQ114K Accurate mass for 114 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ114 iTRAQ4plex114 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ114Y PSI-MOD Accurate mass for 114 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ114 iTRAQ4plex114 MOD:01488 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-114 reporter+balance reagent O4'-acylated tyrosine MOD:01488 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. OMSSA:169 Unimod:532#Y DiffAvg: 144.11 DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono: 144.105919 Formula: (12)C 14 (13)C 2 H 21 N 3 (16)O 2 (18)O 1 MassAvg: 307.17 MassMono: 307.169248 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:532 (4-methylpiperazin-1-yl)acetyl iTRAQ114Y Accurate mass for 114 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ114 iTRAQ4plex114 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex114 MOD:01489 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-114 reporter+balance reagent N'-acylated histidine MOD:01489 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. PubMed:18688235 DiffAvg: 144.11 DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono: 144.105919 Formula: (12)C 11 (13)C 2 H 19 N 5 O 1 (18)O 1 MassAvg: 281.16 MassMono: 281.164831 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex114 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex114 MOD:01490 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-114 reporter+balance reagent O3-acylated serine MOD:01490 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. PubMed:18688235 DiffAvg: 144.11 DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono: 144.105919 Formula: (12)C 8 (13)C 2 H 17 N 3 O 2 (18)O 1 MassAvg: 231.14 MassMono: 231.137947 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex114 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex114 MOD:01491 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-114 reporter+balance reagent O3-acylated threonine MOD:01491 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group. PubMed:18688235 DiffAvg: 144.11 DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1 DiffMono: 144.105919 Formula: (12)C 9 (13)C 2 H 19 N 3 O 2 (18)O 1 MassAvg: 245.15 MassMono: 245.153598 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex114 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ115 iTRAQ4plex115 MOD:01492 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-115 reporter+balance reagent acylated residue MOD:01492 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. Unimod:533 DiffAvg: 144.10 DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono: 144.099599 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:533 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ115 iTRAQ4plex115 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ115nterm PSI-MOD Accurate mass for 115 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ115 iTRAQ4plex115 MOD:01493 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-115 reporter+balance reagent acylated N-terminal MOD:01493 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. OMSSA:170 Unimod:533#N-term DiffAvg: 144.10 DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono: 144.099599 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:533 (4-methylpiperazin-1-yl)acetyl iTRAQ115nterm Accurate mass for 115 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ115 iTRAQ4plex115 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ115K PSI-MOD Accurate mass for 115 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ115 iTRAQ4plex115 MOD:01494 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-115 reporter+balance reagent N6-acylated lysine MOD:01494 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. OMSSA:171 Unimod:533#K DiffAvg: 144.10 DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono: 144.099599 Formula: (12)C 12 (13)C 1 H 24 (14)N 3 (15)N 1 (16)O 1 (18)O 1 MassAvg: 272.19 MassMono: 272.194562 Origin: K Source: artifact TermSpec: none Unimod: Unimod:533 (4-methylpiperazin-1-yl)acetyl iTRAQ115K Accurate mass for 115 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ115 iTRAQ4plex115 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ115Y PSI-MOD Accurate mass for 115 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ115 iTRAQ4plex115 MOD:01495 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-115 reporter+balance reagent O4'-acylated tyrosine MOD:01495 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. OMSSA:172 Unimod:533#Y DiffAvg: 144.10 DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono: 144.099599 Formula: (12)C 15 (13)C 1 H 21 (14)N 2 (15)N 1 (16)O 2 (18)O 1 MassAvg: 307.16 MassMono: 307.162928 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:533 (4-methylpiperazin-1-yl)acetyl iTRAQ115Y Accurate mass for 115 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ115 iTRAQ4plex115 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex115 MOD:01496 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-115 reporter+balance reagent N'-acylated histidine MOD:01496 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. PubMed:18688235 DiffAvg: 144.10 DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono: 144.099599 Formula: (12)C 12 (13)C 1 H 19 (14)N 4 (15)N 1 (16)O 1 (18)O 1 MassAvg: 281.16 MassMono: 281.158511 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex115 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex115 MOD:01497 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-115 reporter+balance reagent O3-acylated serine MOD:01497 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. PubMed:18688235 DiffAvg: 144.10 DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono: 144.099599 Formula: (12)C 9 (13)C 1 H 17 N 1 (14)N 1 (15)N 1 (16)O 2 (18)O 1 MassAvg: 231.13 MassMono: 231.131628 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex115 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex115 MOD:01498 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-115 reporter+balance reagent O3-acylated threonine MOD:01498 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group. PubMed:18688235 DiffAvg: 144.10 DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1 DiffMono: 144.099599 Formula: (12)C 10 (13)C 1 H 19 (14)N 2 (15)N 1 (16)O 2 (18)O 1 MassAvg: 245.15 MassMono: 245.147278 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex115 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex MOD:01499 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-116 reporter+balance reagent acylated residue MOD:01499 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. Unimod:214 DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:214 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ116nterm PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex MOD:01500 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-116 reporter+balance reagent acylated N-terminal MOD:01500 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. OMSSA:173 Unimod:214#N-term DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:214 (4-methylpiperazin-1-yl)acetyl iTRAQ116nterm Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ116K PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex MOD:01501 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-116 reporter+balance reagent N6-acylated lysine MOD:01501 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. OMSSA:174 Unimod:214#K DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1 MassAvg: 272.20 MassMono: 272.197025 Origin: K Source: artifact TermSpec: none Unimod: Unimod:214 (4-methylpiperazin-1-yl)acetyl iTRAQ116K Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ116Y PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex MOD:01502 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-116 reporter+balance reagent O4'-acylated tyrosine MOD:01502 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. OMSSA:175 Unimod:214#Y DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1 MassAvg: 307.17 MassMono: 307.165391 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:214 (4-methylpiperazin-1-yl)acetyl iTRAQ116Y Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex MOD:01503 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-116 reporter+balance reagent N'-acylated histidine MOD:01503 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. PubMed:18688235 DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 10 (13)C 3 H 19 N 3 (14)N 1 (15)N 1 (16)O 2 MassAvg: 281.16 MassMono: 281.160974 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex MOD:01504 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-116 reporter+balance reagent O3-acylated serine MOD:01504 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. PubMed:18688235 DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3 MassAvg: 231.13 MassMono: 231.134091 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex MOD:01505 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-116 reporter+balance reagent O3-acylated threonine MOD:01505 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group. PubMed:18688235 DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3 MassAvg: 245.15 MassMono: 245.149741 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Applied Biosystems mTRAQ(TM) reagent Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex mTRAQ heavy MOD:01506 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue MOD:01506 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. Unimod:214 Unimod:889 DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:214 Unimod: Unimod:889 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Applied Biosystems mTRAQ(TM) reagent Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex mTRAQ heavy A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ117nterm mTRAQ heavy on nterm PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Applied Biosystems mTRAQ(TM) reagent Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex mTRAQ heavy MOD:01507 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated N-terminal MOD:01507 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. OMSSA:176 OMSSA:211 Unimod:214#N-term Unimod:889#N-term DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:214 Unimod: Unimod:889 (4-methylpiperazin-1-yl)acetyl iTRAQ117nterm mTRAQ heavy on nterm Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Applied Biosystems mTRAQ(TM) reagent Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex mTRAQ heavy A protein modification that effectively replaces the N6-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ117K mTRAQ heavy on K PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Applied Biosystems mTRAQ(TM) reagent Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex mTRAQ heavy MOD:01508 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent N6-acylated lysine MOD:01508 A protein modification that effectively replaces the N6-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. OMSSA:177 OMSSA:212 Unimod:214#K Unimod:889#K DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1 MassAvg: 272.20 MassMono: 272.197025 Origin: K Source: artifact TermSpec: none Unimod: Unimod:214 (4-methylpiperazin-1-yl)acetyl iTRAQ117K mTRAQ heavy on K Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Applied Biosystems mTRAQ(TM) reagent Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex mTRAQ heavy A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl iTRAQ117Y mTRAQ heavy on Y PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Applied Biosystems mTRAQ(TM) reagent Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex mTRAQ heavy MOD:01509 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent O4'-acylated tyrosine MOD:01509 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. OMSSA:178 OMSSA:213 Unimod:214#Y Unimod:889#Y DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1 MassAvg: 307.17 MassMono: 307.165391 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:214 Unimod: Unimod:889 (4-methylpiperazin-1-yl)acetyl iTRAQ117Y mTRAQ heavy on Y Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Applied Biosystems mTRAQ(TM) reagent Representative mass and accurate mass for 116 & 117 iTRAQ iTRAQ4plex mTRAQ heavy A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex MOD:01510 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-117 reporter+balance reagent N'-acylated histidine MOD:01510 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. PubMed:18688235 DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 10 (13)C 3 H 19 (14)N 4 (15)N 1 (16)O 2 MassAvg: 281.16 MassMono: 281.160974 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex MOD:01511 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-117 reporter+balance reagent O3-acylated serine MOD:01511 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. PubMed:18688235 DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3 MassAvg: 231.13 MassMono: 231.134091 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ4plex MOD:01512 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex-117 reporter+balance reagent O3-acylated threonine MOD:01512 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group. PubMed:18688235 DiffAvg: 144.10 DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1 DiffMono: 144.102062 Formula: (12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3 MassAvg: 245.15 MassMono: 245.149741 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ4plex Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.1 Da. PSI-MOD MOD:01513 modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da MOD:01513 Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.1 Da. PubMed:18688235 Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.01 Da. PSI-MOD MOD:01514 modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da MOD:01514 Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.01 Da. PubMed:18688235 Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.000001 Da. PSI-MOD MOD:01515 modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da MOD:01515 Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.000001 Da. PubMed:18688235 Modifications that have monoisotopic mass differences from their respective origins of 144.099-144.106 Da. PSI-MOD MOD:01516 modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da. MOD:01516 Modifications that have monoisotopic mass differences from their respective origins of 144.099-144.106 Da. PubMed:18688235 Modifications that have monoisotopic mass differences from their respective origins of 144.102062 Da. PSI-MOD MOD:01517 modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da MOD:01517 Modifications that have monoisotopic mass differences from their respective origins of 144.102062 Da. PubMed:18688235 A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01518 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex reporter+balance reagent acylated residue MOD:01518 A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. Unimod:214 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:214 (4-methylpiperazin-1-yl)acetyl A distinct molecular entity produced from a protein or a protein modification as the result of a fragmentation process. PSI-MOD MOD:01519 The reporter fragment is either itself a modification consisting of atoms derived from the original amino acid residues, or its detection can be taken as evidence that particular modified residues had been present. reporter fragment MOD:01519 A distinct molecular entity produced from a protein or a protein modification as the result of a fragmentation process. PubMed:18688235 A distinct molecular entity produced as the result of a fragmentation process performed on a particular modified residue. PSI-MOD MOD:01520 modification reporter fragment MOD:01520 A distinct molecular entity produced as the result of a fragmentation process performed on a particular modified residue. PubMed:18688235 A protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex reagent derivatized residue. PSI-MOD MOD:01521 iTRAQ4plex reporter fragment MOD:01521 A protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex reagent derivatized residue. PubMed:18688235 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 114 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01522 iTRAQ4plex-114 reporter fragment MOD:01522 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 114 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 5 (13)C 1 H 13 (14)N 2 MassAvg: 114.11 MassMono: 114.110680 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 115 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01523 iTRAQ4plex-115 reporter fragment MOD:01523 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 115 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1 MassAvg: 115.11 MassMono: 115.107715 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 116 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01524 iTRAQ4plex-116 reporter fragment MOD:01524 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 116 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1 MassAvg: 116.11 MassMono: 116.111069 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 117 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01525 iTRAQ4plex-117, mTRAQ heavy, reporter fragment MOD:01525 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 117 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1 MassAvg: 117.11 MassMono: 117.114424 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:01526 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex reporter+balance reagent acylated residue MOD:01526 A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. Unimod:730 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:730 A distinct molecular entity produced from a particular amino acid residue as the result of a fragmentation process. PSI-MOD MOD:01527 residue reporter fragment MOD:01527 A distinct molecular entity produced from a particular amino acid residue as the result of a fragmentation process. PubMed:18688235 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01528 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-113 reporter+balance reagent acylated residue MOD:01528 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. Unimod:730 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01529 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-113 reporter+balance reagent acylated N-terminal MOD:01529 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. Unimod:730#N-term DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01530 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-113 reporter+balance reagent N6-acylated lysine MOD:01530 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. Unimod:730#K DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 MassAvg: 432.30 MassMono: 432.300322 Origin: K Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01531 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-113 reporter+balance reagent O4'-acylated tyrosine MOD:01531 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. Unimod:730#Y DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 MassAvg: 467.27 MassMono: 467.268688 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01532 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-113 reporter+balance reagent N'-acylated histidine MOD:01532 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 MassAvg: 441.26 MassMono: 441.264271 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01533 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-113 reporter+balance reagent O3-acylated serine MOD:01533 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 MassAvg: 391.24 MassMono: 391.237388 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01534 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-113 reporter+balance reagent O3-acylated threonine MOD:01534 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 MassAvg: 405.25 MassMono: 405.253038 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01535 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-114 reporter+balance reagent acylated residue MOD:01535 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. Unimod:730 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01536 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-114 reporter+balance reagent acylated N-terminal MOD:01536 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. Unimod:730#N-term DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01537 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-114 reporter+balance reagent N6-acylated lysine MOD:01537 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. Unimod:730#K DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 MassAvg: 432.30 MassMono: 432.300322 Origin: K Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01538 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-114 reporter+balance reagent O4'-acylated tyrosine MOD:01538 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. Unimod:730#Y DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 MassAvg: 467.27 MassMono: 467.268688 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01539 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-114 reporter+balance reagent N'-acylated histidine MOD:01539 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 MassAvg: 441.26 MassMono: 441.264271 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01540 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-114 reporter+balance reagent O3-acylated serine MOD:01540 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 MassAvg: 391.24 MassMono: 391.237388 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01541 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-114 reporter+balance reagent O3-acylated threonine MOD:01541 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 MassAvg: 405.25 MassMono: 405.253038 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01542 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-115 reporter+balance reagent acylated residue MOD:01542 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. Unimod:731 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01543 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-115 reporter+balance reagent acylated N-terminal MOD:01543 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. Unimod:731#N-term DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01544 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-115 reporter+balance reagent N6-acylated lysine MOD:01544 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. Unimod:731#K DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 MassAvg: 432.29 MassMono: 432.294002 Origin: K Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01545 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-115 reporter+balance reagent O4'-acylated tyrosine MOD:01545 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. Unimod:731#Y DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 MassAvg: 467.26 MassMono: 467.262368 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01546 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-115 reporter+balance reagent N'-derivatized histidine MOD:01546 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 MassAvg: 441.26 MassMono: 441.257951 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01547 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-115 reporter+balance reagent O3-acylated serine MOD:01547 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 MassAvg: 391.23 MassMono: 391.231068 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01548 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-115 reporter+balance reagent O3-acylated threonine MOD:01548 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 MassAvg: 405.25 MassMono: 405.246718 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01549 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-116 reporter+balance reagent acylated residue MOD:01549 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. Unimod:730 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01550 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-116 reporter+balance reagent acylated N-terminal MOD:01550 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. Unimod:730#N-term DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01551 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-116 reporter+balance reagent N6-acylated lysine MOD:01551 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. Unimod:730#K DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 MassAvg: 432.30 MassMono: 432.300322 Origin: K Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01552 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-116 reporter+balance reagent O4'-acylated tyrosine MOD:01552 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. Unimod:730#Y DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 MassAvg: 467.27 MassMono: 467.268688 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01553 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-116 reporter+balance reagent N'-acylated histidine MOD:01553 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 MassAvg: 441.26 MassMono: 441.264271 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01554 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-116 reporter+balance reagent O3-acylated serine MOD:01554 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 MassAvg: 391.24 MassMono: 391.237388 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01555 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-116 reporter+balance reagent O3-acylated threonine MOD:01555 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 MassAvg: 405.25 MassMono: 405.253038 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01556 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-117 reporter+balance reagent acylated residue MOD:01556 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. Unimod:730 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01557 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-117 reporter+balance reagent acylated N-terminal MOD:01557 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. Unimod:730#N-term DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01558 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-117 reporter+balance reagent N6-acylated lysine MOD:01558 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. Unimod:730#K DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4 MassAvg: 432.30 MassMono: 432.300322 Origin: K Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) MOD:01559 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-117 reporter+balance reagent O4'-acylated tyrosine MOD:01559 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. Unimod:730#Y DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5 MassAvg: 467.27 MassMono: 467.268688 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:730 (4-methylpiperazin-1-yl)acetyl Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry Representative mass and accurate mass for 113, 114, 116 & 117 iTRAQ8plex iTRAQ8plex:13C(7)15N(1) A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01560 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-117 reporter+balance reagent N'-acylated histidine MOD:01560 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4 MassAvg: 441.26 MassMono: 441.264271 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01561 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-117 reporter+balance reagent O3-acylated serine MOD:01561 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5 MassAvg: 391.24 MassMono: 391.237388 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01562 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-117 reporter+balance reagent O3-acylated threonine MOD:01562 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group. PubMed:18688235 DiffAvg: 304.21 DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3 DiffMono: 304.205359 Formula: (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5 MassAvg: 405.25 MassMono: 405.253038 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01563 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-118 reporter+balance reagent acylated residue MOD:01563 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. Unimod:731 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01564 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-118 reporter+balance reagent acylated N-terminal MOD:01564 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. Unimod:731#N-term DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01565 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-118 reporter+balance reagent N6-acylated lysine MOD:01565 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. Unimod:731#K DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 MassAvg: 432.29 MassMono: 432.294002 Origin: K Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01566 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-118 reporter+balance reagent O4'-acylated tyrosine MOD:01566 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. Unimod:731#Y DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 MassAvg: 467.26 MassMono: 467.262368 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01567 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-118 reporter+balance reagent N'-acylated histidine MOD:01567 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 MassAvg: 441.26 MassMono: 441.257951 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01568 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-118 reporter+balance reagent O3-acylated serine MOD:01568 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 MassAvg: 391.23 MassMono: 391.231068 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01569 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-118 reporter+balance reagent O3-acylated threonine MOD:01569 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 MassAvg: 405.25 MassMono: 405.246718 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01570 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-119 reporter+balance reagent acylated residue MOD:01570 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. Unimod:731 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01571 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-119 reporter+balance reagent acylated N-terminal MOD:01571 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. Unimod:731#N-term DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01572 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-119 reporter+balance reagent N6-acylated lysine MOD:01572 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. Unimod:731#K DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 MassAvg: 432.29 MassMono: 432.294002 Origin: K Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01573 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-119 reporter+balance reagent O4'-acylated tyrosine MOD:01573 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. Unimod:731#Y DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 MassAvg: 467.26 MassMono: 467.262368 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01574 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-119 reporter+balance reagent N'-acylated histidine MOD:01574 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 MassAvg: 441.26 MassMono: 441.257951 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01575 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-119 reporter+balance reagent O3-acylated serine MOD:01575 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 MassAvg: 391.23 MassMono: 391.231068 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01576 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-119 reporter+balance reagent O3-acylated threonine MOD:01576 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 MassAvg: 405.25 MassMono: 405.246718 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01577 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-121 reporter+balance reagent acylated residue MOD:01577 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. Unimod:731 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01578 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-121 reporter+balance reagent acylated N-terminal MOD:01578 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. Unimod:731#N-term DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01579 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-121 reporter+balance reagent N6-acylated lysine MOD:01579 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. Unimod:731#K DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4 MassAvg: 432.29 MassMono: 432.294002 Origin: K Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) MOD:01580 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-121 reporter+balance reagent O4'-acylated tyrosine MOD:01580 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. Unimod:731#Y DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 MassAvg: 467.26 MassMono: 467.262368 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:731 (4-methylpiperazin-1-yl)acetyl Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry iTRAQ8plex:13C(6)15N(2) A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01581 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-121 reporter+balance reagent N'-acylated histidine MOD:01581 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4 MassAvg: 441.26 MassMono: 441.257951 Origin: H Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01582 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-121 reporter+balance reagent O3-acylated serine MOD:01582 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5 MassAvg: 391.23 MassMono: 391.231068 Origin: S Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01583 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex-121 reporter+balance reagent O3-acylated threonine MOD:01583 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group. PubMed:18688235 DiffAvg: 304.20 DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 DiffMono: 304.199039 Formula: (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5 MassAvg: 405.25 MassMono: 405.246718 Origin: T Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl Modifications that have monoisotopic mass differences from their respective origins of 304.199039 Da. PSI-MOD MOD:01584 modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da MOD:01584 Modifications that have monoisotopic mass differences from their respective origins of 304.199039 Da. PubMed:18688235 A protein modification that effectively crosslinks an L-serine residue and a glycine residue by an ester bond to form O-glycyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0422 (2S)-2-amino-3-[(aminoacetyl)oxy]propanoic acid CROSSLNK Glycyl serine ester (Gly-Ser) (interchain with S-...) CROSSLNK Glycyl serine ester (Ser-Gly) (interchain with G-...) O-(glycyl)-L-serine O3-(aminoacetyl)serine serine glycinate ester PSI-MOD MOD:01585 Cross-link 2. O-glycyl-L-serine MOD:01585 A protein modification that effectively crosslinks an L-serine residue and a glycine residue by an ester bond to form O-glycyl-L-serine. PubMed:17502423 RESID:AA0495 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 5 H 7 N 2 O 3 MassAvg: 143.12 MassMono: 143.045667 Origin: G, S Source: natural TermSpec: C-term (2S)-2-amino-3-[(aminoacetyl)oxy]propanoic acid CROSSLNK Glycyl serine ester (Gly-Ser) (interchain with S-...) CROSSLNK Glycyl serine ester (Ser-Gly) (interchain with G-...) O-(glycyl)-L-serine O3-(aminoacetyl)serine serine glycinate ester A protein modification that effectively crosslinks an L-threonine residue and a glycine residue by an ester bond to form O-glycyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0423 (2S,3R)-2-amino-3-[(aminoacetyl)oxy]butanoic acid CROSSLNK Glycyl threonine ester (Gly-Thr) (interchain with T-...) CROSSLNK Glycyl threonine ester (Thr-Gly) (interchain with G-...) O-(glycyl)-L-threonine O3-(2-aminoacetyl)threonine threonine glycinate ester PSI-MOD MOD:01586 Cross-link 2. O-glycyl-L-threonine MOD:01586 A protein modification that effectively crosslinks an L-threonine residue and a glycine residue by an ester bond to form O-glycyl-L-threonine. PubMed:17502423 RESID:AA0496 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 6 H 9 N 2 O 3 MassAvg: 157.15 MassMono: 157.061317 Origin: G, T Source: natural TermSpec: C-term (2S,3R)-2-amino-3-[(aminoacetyl)oxy]butanoic acid CROSSLNK Glycyl threonine ester (Gly-Thr) (interchain with T-...) CROSSLNK Glycyl threonine ester (Thr-Gly) (interchain with G-...) O-(glycyl)-L-threonine O3-(2-aminoacetyl)threonine threonine glycinate ester A protein modification that effectively converts an L-serine residue to O-(2-aminoethylphosphoryl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0399 (2S)-2-amino-3-([(2-aminoethoxy)(hydroxy)phosphoryl]oxy)propanoic acid MOD_RES O-(2-aminoethylphosphoryl)serine O-(2-aminoethylphosphoryl)-L-serine O3-(2-aminoethylphosphoryl)-L-serine O3-(phosphoethanolamine)-L-serine serine ethanolamine phosphate serine ethanolamine phosphodiester PSI-MOD MOD:01587 O-(2-aminoethylphosphoryl)-L-serine MOD:01587 A protein modification that effectively converts an L-serine residue to O-(2-aminoethylphosphoryl)-L-serine. PubMed:15249686 PubMed:16825186 PubMed:16949362 RESID:AA0497 DiffAvg: 123.05 DiffFormula: C 2 H 6 N 1 O 3 P 1 DiffMono: 123.008530 Formula: C 5 H 11 N 2 O 5 P 1 MassAvg: 210.13 MassMono: 210.040558 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-([(2-aminoethoxy)(hydroxy)phosphoryl]oxy)propanoic acid MOD_RES O-(2-aminoethylphosphoryl)serine O-(2-aminoethylphosphoryl)-L-serine O3-(2-aminoethylphosphoryl)-L-serine O3-(phosphoethanolamine)-L-serine serine ethanolamine phosphate serine ethanolamine phosphodiester A protein modification that effectively converts an L-serine residue to O-cholinephosphoryl-L-serine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0400 2-[([(2S)-2-amino-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanaminium 2-[([(2S)-2-azanyl-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanazanium MOD_RES O-(2-cholinephosphoryl)serine O-cholinephosphoryl-L-serine O3-[(2-[trimethylammonio]ethyl)phosphoryl]-L-serine O3-phosphocholine-L-serine serine choline phosphate serine choline phosphodiester PSI-MOD MOD:01588 O-cholinephosphoryl-L-serine MOD:01588 A protein modification that effectively converts an L-serine residue to O-cholinephosphoryl-L-serine. PubMed:15249686 PubMed:16825186 PubMed:16949362 RESID:AA0498 DiffAvg: 166.14 DiffFormula: C 5 H 13 N 1 O 3 P 1 DiffMono: 166.062756 FormalCharge: 1+ Formula: C 8 H 18 N 2 O 5 P 1 MassAvg: 253.21 MassMono: 253.094785 Origin: S Source: natural TermSpec: none 2-[([(2S)-2-amino-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanaminium 2-[([(2S)-2-azanyl-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanazanium MOD_RES O-(2-cholinephosphoryl)serine O-cholinephosphoryl-L-serine O3-[(2-[trimethylammonio]ethyl)phosphoryl]-L-serine O3-phosphocholine-L-serine serine choline phosphate serine choline phosphodiester A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0547 (2S)-2-amino-3-[(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)oxy]propanoic acid CARBOHYD O-linked (DADDGlc) serine DADDGlc O-(2,4-diacetamido-2,4-dideoxy-D-glucosyl)-L-serine O-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine O-[2,4-bis(acetylamino)]glucosyl-L-serine O-seryl-beta-2,4-bis(acetylamino)glucoside O3-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine PSI-MOD MOD:01589 O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine MOD:01589 A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine. PubMed:15249686 PubMed:16949362 RESID:AA0499 DiffAvg: 244.25 DiffFormula: C 10 H 16 N 2 O 5 DiffMono: 244.105922 Formula: C 13 H 21 N 3 O 7 MassAvg: 331.33 MassMono: 331.137950 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-[(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)oxy]propanoic acid CARBOHYD O-linked (DADDGlc) serine DADDGlc O-(2,4-diacetamido-2,4-dideoxy-D-glucosyl)-L-serine O-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine O-[2,4-bis(acetylamino)]glucosyl-L-serine O-seryl-beta-2,4-bis(acetylamino)glucoside O3-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine A protein modification that effectively converts an L-tryptophan residue to 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,3aR,8aS)-3a-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan LIPID 3'-farnesyl-2',N2-cyclotryptophan PSI-MOD MOD:01590 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan MOD:01590 A protein modification that effectively converts an L-tryptophan residue to 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan. ChEBI:52950 PubMed:18323630 RESID:AA0500 DiffAvg: 204.36 DiffFormula: C 15 H 24 N 0 O 0 DiffMono: 204.187801 Formula: C 26 H 34 N 2 O 1 MassAvg: 390.57 MassMono: 390.267114 Origin: W Source: natural TermSpec: none (2S,3aR,8aS)-3a-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan LIPID 3'-farnesyl-2',N2-cyclotryptophan Modifications that have monoisotopic mass differences from their respective origins of 304.205359 Da. PSI-MOD MOD:01591 modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da MOD:01591 Modifications that have monoisotopic mass differences from their respective origins of 304.205359 Da. PubMed:18688235 Modifications that have monoisotopic mass differences from their respective origins of 304.199-304.206 Da. PSI-MOD MOD:01592 modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da MOD:01592 Modifications that have monoisotopic mass differences from their respective origins of 304.199-304.206 Da. PubMed:18688235 A protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex reagent derivatized residue. 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01593 iTRAQ8plex reporter fragment MOD:01593 A protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex reagent derivatized residue. PubMed:18688235 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-113 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01594 iTRAQ8plex-113 reporter fragment MOD:01594 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-113 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 6 H 13 (14)N 2 MassAvg: 113.11 MassMono: 113.107325 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-114 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01595 iTRAQ8plex-114 reporter fragment MOD:01595 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-114 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 5 (13)C 1 H 13 (14)N 2 MassAvg: 114.11 MassMono: 114.110680 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-115 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01596 iTRAQ8plex-115 reporter fragment MOD:01596 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-115 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1 MassAvg: 115.11 MassMono: 115.107715 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-116 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01597 iTRAQ8plex-116 reporter fragment MOD:01597 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-116 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1 MassAvg: 116.11 MassMono: 116.111069 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-117 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01598 iTRAQ8plex-117 reporter fragment MOD:01598 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-117 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1 MassAvg: 117.11 MassMono: 117.114424 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-118 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01599 iTRAQ8plex-118 reporter fragment MOD:01599 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-118 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 3 (13)C 3 H 13 (15)N 2 MassAvg: 118.11 MassMono: 118.111459 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-119 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01600 iTRAQ8plex-119 reporter fragment MOD:01600 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-119 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 2 (13)C 4 H 13 (15)N 2 MassAvg: 119.11 MassMono: 119.114814 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-121 reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01601 iTRAQ8plex-121 reporter fragment MOD:01601 The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-121 reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (13)C 6 H 13 (15)N 2 MassAvg: 121.12 MassMono: 121.121524 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium A protein modification that effectively converts an L-lysine residue, and an L-methionine residue to S-(L-lysyl)-L-methionine sulfilimine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0401 (2S)-2-amino-6-([(E)-[(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene]amino)hexanoic acid (E)-N6-([(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene)-L-lysine S-(L-lysyl)-L-methionine sulfilimine S-lysyl-methionine PSI-MOD MOD:01602 Cross-link 2. S-(L-lysyl)-L-methionine sulfilimine MOD:01602 A protein modification that effectively converts an L-lysine residue, and an L-methionine residue to S-(L-lysyl)-L-methionine sulfilimine. PubMed:12011424 PubMed:15951440 PubMed:19729652 RESID:AA0501 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 11 H 19 N 3 O 2 S 1 MassAvg: 257.35 MassMono: 257.119798 Origin: K, M Source: natural TermSpec: none (2S)-2-amino-6-([(E)-[(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene]amino)hexanoic acid (E)-N6-([(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene)-L-lysine S-(L-lysyl)-L-methionine sulfilimine S-lysyl-methionine A protein modification that effectively converts an L-lysine residue to 2x(15)N labeled L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD MOD:01603 2x(15)N labeled L-lysine MOD:01603 A protein modification that effectively converts an L-lysine residue to 2x(15)N labeled L-lysine. PubMed:18688235 URL:http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=609021|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC&lang=en_US0.000000E+000 DiffAvg: 1.99 DiffFormula: (14)N -2 (15)N 2 DiffMono: 1.994070 Formula: C 6 H 12 (15)N 2 O 1 MassAvg: 130.09 MassMono: 130.089033 Origin: K Source: artifact TermSpec: none Unimod: Unimod:995 A protein modification that effectively converts an L-arginine residue to 4x(15)N labeled L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01604 4x(15)N labeled L-arginine MOD:01604 A protein modification that effectively converts an L-arginine residue to 4x(15)N labeled L-arginine. PubMed:18688235 URL:http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=600113|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC&lang=en_US0.000000E+000 DiffAvg: 3.99 DiffFormula: (14)N -4 (15)N 4 DiffMono: 3.988140 Formula: C 6 H 12 (15)N 4 O 1 MassAvg: 160.09 MassMono: 160.089251 Origin: R Source: artifact TermSpec: none A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0406 (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanedioic acid 5-glutamyl 2-aminoadipic acid MOD_RES 5-glutamyl 2-aminoadipic acid N2-(gamma-glutamyl)-2-aminoadipic acid N2-(isoglutamyl)-2-aminoadipic acid PSI-MOD MOD:01605 5-glutamyl 2-aminoadipic acid MOD:01605 A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic acid. ChEBI:78503 PubMed:19620981 RESID:AA0502 DiffAvg: 143.14 DiffFormula: C 6 H 9 N 1 O 3 DiffMono: 143.058243 Formula: C 11 H 16 N 2 O 6 MassAvg: 272.26 MassMono: 272.100836 Origin: E Source: natural TermSpec: none (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanedioic acid 5-glutamyl 2-aminoadipic acid MOD_RES 5-glutamyl 2-aminoadipic acid N2-(gamma-glutamyl)-2-aminoadipic acid N2-(isoglutamyl)-2-aminoadipic acid A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic 6-phosphoric anhydride. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxo-6-(phosphonooxy)hexanoic acid 5-glutamyl 2-aminoadipic 6-phosphoric anhydride PSI-MOD MOD:01606 5-glutamyl 2-aminoadipic 6-phosphoric anhydride MOD:01606 A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic 6-phosphoric anhydride. PubMed:19620981 RESID:AA0503 DiffAvg: 223.12 DiffFormula: C 6 H 10 N 1 O 6 P 1 DiffMono: 223.024574 Formula: C 11 H 17 N 2 O 9 P 1 MassAvg: 352.24 MassMono: 352.067167 Origin: E Source: hypothetical TermSpec: none (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxo-6-(phosphonooxy)hexanoic acid 5-glutamyl 2-aminoadipic 6-phosphoric anhydride A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl allysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxohexanoic acid 2-(5-glutamyl)amino-6-oxohexanoic acid 5-glutamyl allysine N2-(gamma-glutamyl)allysine N2-(isoglutamyl)allysine alpha-(gamma-glutamyl)allysine PSI-MOD MOD:01607 5-glutamyl allysine MOD:01607 A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl allysine. PubMed:19620981 RESID:AA0504 DiffAvg: 127.14 DiffFormula: C 6 H 9 N 1 O 2 DiffMono: 127.063329 Formula: C 11 H 16 N 2 O 5 MassAvg: 256.26 MassMono: 256.105922 Origin: E Source: hypothetical TermSpec: none (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxohexanoic acid 2-(5-glutamyl)amino-6-oxohexanoic acid 5-glutamyl allysine N2-(gamma-glutamyl)allysine N2-(isoglutamyl)allysine alpha-(gamma-glutamyl)allysine A protein modification that effectively converts an L-glutamic acid residue to N2-(L-isoglutamyl)-L-lysine. This is not an isopeptide cross-link. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0407 (2S)-6-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid 5-glutamyl N2-lysine MOD_RES 5-glutamyl N2-lysine N2-(L-isoglutamyl)-L-lysine N2-(gamma-glutamyl)lysine alpha-(gamma-glutamyl)lysine gamma-glutamyl N2-lysine PSI-MOD MOD:01608 N2-(L-isoglutamyl)-L-lysine MOD:01608 A protein modification that effectively converts an L-glutamic acid residue to N2-(L-isoglutamyl)-L-lysine. This is not an isopeptide cross-link. PubMed:19620981 RESID:AA0505 DiffAvg: 128.18 DiffFormula: C 6 H 12 N 2 O 1 DiffMono: 128.094963 Formula: C 11 H 19 N 3 O 4 MassAvg: 257.29 MassMono: 257.137556 Origin: E Source: natural TermSpec: none (2S)-6-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid 5-glutamyl N2-lysine MOD_RES 5-glutamyl N2-lysine N2-(L-isoglutamyl)-L-lysine N2-(gamma-glutamyl)lysine alpha-(gamma-glutamyl)lysine gamma-glutamyl N2-lysine A protein modification that effectively converts an L-tryptophan residue to 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0504 (2S)-2-amino-3-[7-hydroxy-2-(alpha-D-mannopyranosyl)-1H-indol-3-yl]propanoic acid 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan CARBOHYD C-linked (Man) hydroxytryptophan PSI-MOD MOD:01609 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan MOD:01609 A protein modification that effectively converts an L-tryptophan residue to 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan. PubMed:19584055 RESID:AA0506 DiffAvg: 178.14 DiffFormula: C 6 H 10 N 0 O 6 DiffMono: 178.047738 Formula: C 17 H 20 N 2 O 7 MassAvg: 364.35 MassMono: 364.127051 Origin: W Source: natural TermSpec: none (2S)-2-amino-3-[7-hydroxy-2-(alpha-D-mannopyranosyl)-1H-indol-3-yl]propanoic acid 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan CARBOHYD C-linked (Man) hydroxytryptophan A protein modification that effectively converts an L-threonine residue to L-threonine methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0412 L-threonine methyl ester MOD_RES Threonine methyl ester methyl (2S,3R)-2-amino-3-hydroxybutanoate methyl L-threoninate PSI-MOD MOD:01610 L-threonine methyl ester MOD:01610 A protein modification that effectively converts an L-threonine residue to L-threonine methyl ester. PubMed:19745839 RESID:AA0507 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 5 H 10 N 1 O 3 MassAvg: 132.14 MassMono: 132.066068 Origin: T Source: natural TermSpec: C-term L-threonine methyl ester MOD_RES Threonine methyl ester methyl (2S,3R)-2-amino-3-hydroxybutanoate methyl L-threoninate A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-trihydrogen phosphate 6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FMN 6-(S-cysteinyl)-8alpha-(N(delta)-histidyl)-FMN 6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FMN 6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FMN 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FMN BINDING FMN (covalent; via 2 links) BINDING FMN (covalent; via 2 links, pros nitrogen) PSI-MOD MOD:01611 Cross-link 2. 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN MOD:01611 A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN. PubMed:17935335 RESID:AA0508 DiffAvg: 452.32 DiffFormula: C 17 H 17 N 4 O 9 P 1 S 0 DiffMono: 452.073315 Formula: C 26 H 29 N 8 O 11 P 1 S 1 MassAvg: 692.60 MassMono: 692.141411 Origin: C, H Source: natural TermSpec: none 6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-trihydrogen phosphate 6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FMN 6-(S-cysteinyl)-8alpha-(N(delta)-histidyl)-FMN 6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FMN 6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FMN 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FMN BINDING FMN (covalent; via 2 links) BINDING FMN (covalent; via 2 links, pros nitrogen) A protein modification that effectively converts an L-tyrosine residue to 3'-iodo-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0411 (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid 3'-iodo-L-tyrosine 3-iodo-L-tyrosine 3-iodotyrosine 4-hydroxy-3-iodo-phenylalanine MIT MOD_RES Iodotyrosine PSI-MOD MOD:01612 3'-iodo-L-tyrosine MOD:01612 A protein modification that effectively converts an L-tyrosine residue to 3'-iodo-L-tyrosine. ChEBI:27847 PubMed:8995307 RESID:AA0509 DiffAvg: 125.90 DiffFormula: C 0 H -1 I 1 N 0 O 0 DiffMono: 125.896648 Formula: C 9 H 8 I 1 N 1 O 2 MassAvg: 289.07 MassMono: 288.959976 Origin: Y Source: natural TermSpec: none (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid 3'-iodo-L-tyrosine 3-iodo-L-tyrosine 3-iodotyrosine 4-hydroxy-3-iodo-phenylalanine MIT MOD_RES Iodotyrosine A protein modification that effectively converts an L-tyrosine residue to 3',5'-diiodo-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0408 (2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid 3',5'-diiodo-L-tyrosine 3,5-diiodo-L-tyrosine 3,5-diiodotyrosine DIT MOD_RES Diiodotyrosine iodogorgoic acid PSI-MOD MOD:01613 3',5'-diiodo-L-tyrosine MOD:01613 A protein modification that effectively converts an L-tyrosine residue to 3',5'-diiodo-L-tyrosine. ChEBI:15768 PubMed:8995307 RESID:AA0510 DiffAvg: 251.79 DiffFormula: C 0 H -2 I 2 N 0 O 0 DiffMono: 251.793295 Formula: C 9 H 7 I 2 N 1 O 2 MassAvg: 414.97 MassMono: 414.856624 Origin: Y Source: natural TermSpec: none (2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid 3',5'-diiodo-L-tyrosine 3,5-diiodo-L-tyrosine 3,5-diiodotyrosine DIT MOD_RES Diiodotyrosine iodogorgoic acid A protein modification that effectively converts a glycine residue to glycyl phospho-5'-adenosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0409 (2-aminoacetyl)oxy-([(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy)phosphinic acid ([(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl)-2-aminoethanoate 5'-adenylic-glyinate MOD_RES Glycyl adenylate aminoacetyl [5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen phosphate glycine monoanhydride with 5'-adenylic acid glycyl 5'-adenylate glycyl adenosine-5'-phosphate glycyl phospho-5'-adenosine glycyladenylate PSI-MOD MOD:01614 glycyl phospho-5'-adenosine MOD:01614 A protein modification that effectively converts a glycine residue to glycyl phospho-5'-adenosine. PubMed:16388576 PubMed:9632726 RESID:AA0511 DiffAvg: 329.21 DiffFormula: C 10 H 12 N 5 O 6 P 1 DiffMono: 329.052520 Formula: C 12 H 16 N 6 O 8 P 1 MassAvg: 403.27 MassMono: 403.076723 Origin: G Source: natural TermSpec: C-term (2-aminoacetyl)oxy-([(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy)phosphinic acid ([(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl)-2-aminoethanoate 5'-adenylic-glyinate MOD_RES Glycyl adenylate aminoacetyl [5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen phosphate glycine monoanhydride with 5'-adenylic acid glycyl 5'-adenylate glycyl adenosine-5'-phosphate glycyl phospho-5'-adenosine glycyladenylate A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a dithioester bond to form glycyl cysteine dithioester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0410 (2R)-2-amino-3-[(aminoacetyl)disulfanyl]propanoic acid 2-(glycyldithio)alanine S-glycyl cysteine persulfide S-glycyl thiocysteine glycyl cysteine dithioester thioglycine cysteine disulfide PSI-MOD MOD:01615 Cross-link 2. glycyl cysteine dithioester MOD:01615 A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a dithioester bond to form glycyl cysteine dithioester. PubMed:11438688 PubMed:16388576 RESID:AA0512 DiffAvg: 14.05 DiffFormula: C 0 H -2 N 0 O -1 S 1 DiffMono: 13.961506 Formula: C 5 H 7 N 2 O 2 S 2 MassAvg: 191.24 MassMono: 190.994894 Origin: C, G Source: hypothetical TermSpec: C-term (2R)-2-amino-3-[(aminoacetyl)disulfanyl]propanoic acid 2-(glycyldithio)alanine S-glycyl cysteine persulfide S-glycyl thiocysteine glycyl cysteine dithioester thioglycine cysteine disulfide A protein modification that effectively cross-links two L-cysteine residues and adds three sulfur atoms to form trithiocystine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0417 (2R,2'R)-3,3'-pentasulfane-1,5-diylbis(2-aminopropanoic acid) 3,3'-pentathiobisalanine bis(2-amino-2-carboxyethyl)pentasulfide trithiocystine PSI-MOD MOD:01616 Cross-link 2. trithiocystine MOD:01616 A protein modification that effectively cross-links two L-cysteine residues and adds three sulfur atoms to form trithiocystine. PubMed:19438211 RESID:AA0513 DiffAvg: 94.16 DiffFormula: C 0 H -2 N 0 O 0 S 3 DiffMono: 93.900563 Formula: C 6 H 8 N 2 O 2 S 5 MassAvg: 300.44 MassMono: 299.918933 Origin: C, C Source: natural TermSpec: none (2R,2'R)-3,3'-pentasulfane-1,5-diylbis(2-aminopropanoic acid) 3,3'-pentathiobisalanine bis(2-amino-2-carboxyethyl)pentasulfide trithiocystine A protein modification that effectively converts an L-threonine residue to O-(6-phosphomannosyl)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0596 (2S,3R)-2-amino-3-[6-phosphonooxy-alpha-D-mannopyranosyloxy]butanoic acid CARBOHYD O-linked (Man6P) threonine O-(6-phosphomannosyl)-L-threonine O3-(6-phosphomannosyl)threonine PSI-MOD MOD:01617 O-(6-phosphomannosyl)-L-threonine MOD:01617 A protein modification that effectively converts an L-threonine residue to O-(6-phosphomannosyl)-L-threonine. PubMed:20044576 RESID:AA0514 DiffAvg: 242.12 DiffFormula: C 6 H 11 N 0 O 8 P 1 DiffMono: 242.019154 Formula: C 10 H 18 N 1 O 10 P 1 MassAvg: 343.22 MassMono: 343.066832 Origin: T Source: natural TermSpec: none (2S,3R)-2-amino-3-[6-phosphonooxy-alpha-D-mannopyranosyloxy]butanoic acid CARBOHYD O-linked (Man6P) threonine O-(6-phosphomannosyl)-L-threonine O3-(6-phosphomannosyl)threonine A protein modification that effectively converts an L-alaine residue and an L-asparagine residue to L-alanyl-L-isoaspartyl cyclopeptide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0418 (2S,5S)-2-methyl-3,7-dioxo-1,4-diazepane-5-carboxylic acid 1,4.2-anhydro(L-alanyl-L-aspartic acid) CROSSLNK Alanine isoaspartyl cyclopeptide (Ala-Asn) L-alanyl-L-isoaspartyl cyclopeptide PSI-MOD MOD:01618 Cross-link 2. L-alanyl-L-isoaspartyl cyclopeptide MOD:01618 A protein modification that effectively converts an L-alaine residue and an L-asparagine residue to L-alanyl-L-isoaspartyl cyclopeptide. PubMed:19928958 PubMed:3207697 RESID:AA0515 DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 7 H 9 N 2 O 3 MassAvg: 169.16 MassMono: 169.061317 Origin: A, N Source: natural TermSpec: N-term (2S,5S)-2-methyl-3,7-dioxo-1,4-diazepane-5-carboxylic acid 1,4.2-anhydro(L-alanyl-L-aspartic acid) CROSSLNK Alanine isoaspartyl cyclopeptide (Ala-Asn) L-alanyl-L-isoaspartyl cyclopeptide A protein modification that crosslinks two cysteine residues by formation of a chain of two or more bonded sulfur atoms. PSI-MOD MOD:01619 multisulfide crosslinked residues MOD:01619 A protein modification that crosslinks two cysteine residues by formation of a chain of two or more bonded sulfur atoms. PubMed:18688235 A protein modification that crosslinks two cysteine residues by formation of a chain of three or more bonded sulfur atoms. PSI-MOD MOD:01620 polysulfide crosslinked residues MOD:01620 A protein modification that crosslinks two cysteine residues by formation of a chain of three or more bonded sulfur atoms. PubMed:18688235 A protein modification that crosslinks two or more amino acid residues by forming an adduct with a compound containing a flavin group. PSI-MOD MOD:01621 flavin crosslinked residues MOD:01621 A protein modification that crosslinks two or more amino acid residues by forming an adduct with a compound containing a flavin group. PubMed:18688235 A protein modification that effectively converts an L-tryptophan residue to one of several monohydroxylated tryptophan residues, including 3-hydroxy-L-tryptophan and 7'-hydroxy-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: oxyw PSI-MOD Oxidation MOD:01622 monohydroxylated tryptophan MOD:01622 A protein modification that effectively converts an L-tryptophan residue to one of several monohydroxylated tryptophan residues, including 3-hydroxy-L-tryptophan and 7'-hydroxy-L-tryptophan. OMSSA:90 Unimod:35#W DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 11 H 10 N 2 O 2 MassAvg: 202.21 MassMono: 202.074228 Origin: W Source: natural TermSpec: none Unimod: Unimod:35 oxyw Oxidation A protein modification that effectively converts a glycine residue to a C-terminal 1-thioglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01623 1-thioglycine (C-terminal) MOD:01623 A protein modification that effectively converts a glycine residue to a C-terminal 1-thioglycine. PubMed:11463785 PubMed:19145231 PubMed:9367957 RESID:AA0265#var DiffAvg: 16.06 DiffFormula: C 0 H 0 N 0 O -1 S 1 DiffMono: 15.977156 Formula: C 2 H 3 N 1 S 1 MassAvg: 73.11 MassMono: 72.998620 Origin: G Source: natural TermSpec: C-term A protein modification that crosslinks an asparagine and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the release of ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0450 (2-aminosuccinimidyl)acetic acid (3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid CROSSLNK (2-aminosuccinimidyl)acetic acid (Asn-Gly) N-(2-aminosuccinyl)glycine [(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid anhydroaspartyl glycine aspartimide glycine PSI-MOD MOD:01624 Cross-link 2. (2-aminosuccinimidyl)acetic acid (Asn) MOD:01624 A protein modification that crosslinks an asparagine and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the release of ammonia. PubMed:10801322 PubMed:2015294 RESID:AA0441#ASN DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 6 H 6 N 2 O 3 MassAvg: 154.13 MassMono: 154.037842 Origin: G, N Source: hypothetical TermSpec: none (2-aminosuccinimidyl)acetic acid (3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid CROSSLNK (2-aminosuccinimidyl)acetic acid (Asn-Gly) N-(2-aminosuccinyl)glycine [(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid anhydroaspartyl glycine aspartimide glycine A protein modification that effectively converts a glycine residue to 1-thioglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: 1-thioglycine 2-amino-1-sulfanylethanone MOD_RES 1-thioglycine S(O)Gly aminoethanethioic acid aminothioacetic acid PSI-MOD Carboxy->Thiocarboxy thiocarboxylic acid MOD:01625 This modification occurs naturally in two forms. At an interior peptide location (MOD:00270) it exists as aminoethanethionic acid, or aminoethanethioic O-acid. At the C-terminal (MOD:01623) it exists as aminoethanethiolic acid, or aminoethanethioic S-acid [JSG]. 1-thioglycine MOD:01625 A protein modification that effectively converts a glycine residue to 1-thioglycine. PubMed:11463785 PubMed:9367957 RESID:AA0265 DiffAvg: 16.06 DiffFormula: C 0 H 0 N 0 O -1 S 1 DiffMono: 15.977156 Formula: none MassAvg: none MassMono: none Origin: G Source: natural 1-thioglycine 2-amino-1-sulfanylethanone MOD_RES 1-thioglycine S(O)Gly aminoethanethioic acid aminothioacetic acid Carboxy->Thiocarboxy thiocarboxylic acid A protein modification that forms L-cystine by forming a disulfide bond that either cross-links two peptidyl L-cysteine residues, or modifies a peptidyl cysteine with a free cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) 3,3'-dithiobis(2-aminopropanoic acid) 3,3'-dithiobisalanine 3,3'-dithiodialanine Cys2 Cystine ((Cys)2) L-cystine beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide beta,beta'-dithiodialanine bis(alpha-aminopropionic acid)-beta-disulfide bis(beta-amino-beta-carboxyethyl)disulfide dicysteine PSI-MOD 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid MOD:01626 This modification occurs naturally in two forms. It exists as a disulfide cross-link of two cysteine residues (MOD:00034), or as a disulfide cross-link of a cysteine residues and a free cysteine (MOD:00765). L-cystine MOD:01626 A protein modification that forms L-cystine by forming a disulfide bond that either cross-links two peptidyl L-cysteine residues, or modifies a peptidyl cysteine with a free cysteine. ChEBI:16283 PubMed:1988019 PubMed:2001356 PubMed:2076469 PubMed:3083866 PubMed:366603 PubMed:7918467 PubMed:8344916 RESID:AA0025 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: none MassAvg: none MassMono: none Origin: none Source: natural TermSpec: none (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) 3,3'-dithiobis(2-aminopropanoic acid) 3,3'-dithiobisalanine 3,3'-dithiodialanine Cys2 Cystine ((Cys)2) L-cystine beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide beta,beta'-dithiodialanine bis(alpha-aminopropionic acid)-beta-disulfide bis(beta-amino-beta-carboxyethyl)disulfide dicysteine 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid A protein modification that forms L-cysteinyl-L-selenocysteine either by the natural process of cross-linking an L-cysteine residue and an L-selenocysteine residue, or by the hypothetical process of substituting a selenium for a sulfur atom in cystine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01627 Cross-link 2. L-cysteinyl-L-selenocysteine MOD:01627 A protein modification that forms L-cysteinyl-L-selenocysteine either by the natural process of cross-linking an L-cysteine residue and an L-selenocysteine residue, or by the hypothetical process of substituting a selenium for a sulfur atom in cystine. PubMed:12911312 PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 6 H 8 N 2 O 2 S 1 Se 1 MassAvg: 251.17 MassMono: 251.947170 Origin: C, X Source: natural TermSpec: none A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following glycine residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01628 Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. (2-aminosuccinimidyl)acetic acid MOD:01628 A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following glycine residue. PubMed:10801322 PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 6 H 6 N 2 O 3 MassAvg: 154.13 MassMono: 154.037842 Origin: G, X Source: hypothetical TermSpec: none A protein modification that forms cyclo[(prolylserin)-O-yl] cysteinate by the natural process of cross-linking an L-cysteine residue an L-proline residue, and an L-serine residue, or by effectively modifying a cysteine residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate cyclo[(prolylserin)-O-yl] cysteinate PSI-MOD MOD:01629 cyclo[(prolylserin)-O-yl] cysteinate MOD:01629 A protein modification that forms cyclo[(prolylserin)-O-yl] cysteinate by the natural process of cross-linking an L-cysteine residue an L-proline residue, and an L-serine residue, or by effectively modifying a cysteine residue. PubMed:7961166 RESID:AA0489 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 11 H 16 N 3 O 4 S 1 MassAvg: 286.33 MassMono: 286.086152 Origin: X Source: natural TermSpec: C-term (3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate [(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate cyclo[(prolylserin)-O-yl] cysteinate A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine . DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0397 (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid 5-glutamyl N6-lysine N alpha -(gamma-Glutamyl)-lysine N(epsilon)-(gamma-glutamyl)lysine N6-(L-isoglutamyl)-L-lysine PSI-MOD MOD:01630 Cross-link 2. N6-(L-isoglutamyl)-L-lysine MOD:01630 A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine . ChEBI:21863 DeltaMass:0 PubMed:2461365 PubMed:5637041 PubMed:5656070 PubMed:8598899 RESID:AA0124 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 11 H 17 N 3 O 3 MassAvg: 239.27 MassMono: 239.126991 Origin: K, X Source: natural TermSpec: none (2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid 2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid 5-glutamyl N6-lysine N alpha -(gamma-Glutamyl)-lysine N(epsilon)-(gamma-glutamyl)lysine N6-(L-isoglutamyl)-L-lysine A protein modification that effectively removes or replaces an L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01631 This represents the loss or replacement of an L-alanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-alanine removal MOD:01631 A protein modification that effectively removes or replaces an L-alanine. PubMed:18688235 DiffAvg: -71.08 DiffFormula: C -3 H -5 N -1 O -1 DiffMono: -71.037114 Formula: none MassAvg: none MassMono: none Origin: A Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01632 This represents the loss or replacement of an L-arginine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-arginine removal MOD:01632 A protein modification that effectively removes or replaces an L-arginine. PubMed:18688235 DiffAvg: -156.19 DiffFormula: C -6 H -12 N -4 O -1 DiffMono: -156.101111 Formula: none MassAvg: none MassMono: none Origin: R Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01633 This represents the loss or replacement of an L-asparagine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-asparagine removal MOD:01633 A protein modification that effectively removes or replaces an L-asparagine. PubMed:18688235 DiffAvg: -114.10 DiffFormula: C -4 H -6 N -2 O -2 DiffMono: -114.042927 Formula: none MassAvg: none MassMono: none Origin: N Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-aspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01634 This represents the loss or replacement of an L-aspartic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-aspartic acid removal MOD:01634 A protein modification that effectively removes or replaces an L-aspartic acid. PubMed:18688235 DiffAvg: -115.09 DiffFormula: C -4 H -5 N -1 O -3 DiffMono: -115.026943 Formula: none MassAvg: none MassMono: none Origin: D Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01635 This represents the loss or replacement of an L-cysteine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-cysteine removal MOD:01635 A protein modification that effectively removes or replaces an L-cysteine. PubMed:18688235 DiffAvg: -103.14 DiffFormula: C -3 H -5 N -1 O -1 S -1 DiffMono: -103.009185 Formula: none MassAvg: none MassMono: none Origin: C Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-glutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01636 This represents the loss or replacement of an L-glutamic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-glutamic acid removal MOD:01636 A protein modification that effectively removes or replaces an L-glutamic acid. PubMed:18688235 DiffAvg: -129.12 DiffFormula: C -5 H -7 N -1 O -3 DiffMono: -129.042593 Formula: none MassAvg: none MassMono: none Origin: E Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-glutamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01637 This represents the loss or replacement of an L-glutamine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-glutamine removal MOD:01637 A protein modification that effectively removes or replaces an L-glutamine. PubMed:18688235 DiffAvg: -128.13 DiffFormula: C -5 H -8 N -2 O -2 DiffMono: -128.058578 Formula: none MassAvg: none MassMono: none Origin: Q Source: natural TermSpec: none A protein modification that effectively removes or replaces a glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01638 This represents the loss or replacement of an glycine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. glycine removal MOD:01638 A protein modification that effectively removes or replaces a glycine. PubMed:18688235 DiffAvg: -57.05 DiffFormula: C -2 H -3 N -1 O -1 DiffMono: -57.021464 Formula: none MassAvg: none MassMono: none Origin: G Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01639 This represents the loss or replacement of an L-histidine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-histidine removal MOD:01639 A protein modification that effectively removes or replaces an L-histidine. PubMed:18688235 DiffAvg: -137.14 DiffFormula: C -6 H -7 N -3 O -1 DiffMono: -137.058912 Formula: none MassAvg: none MassMono: none Origin: H Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01640 This represents the loss or replacement of an L-isoleucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-isoleucine removal MOD:01640 A protein modification that effectively removes or replaces an L-isoleucine. PubMed:18688235 DiffAvg: -113.16 DiffFormula: C -6 H -11 N -1 O -1 DiffMono: -113.084064 Formula: none MassAvg: none MassMono: none Origin: I Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01641 This represents the loss or replacement of an L-leucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-leucine removal MOD:01641 A protein modification that effectively removes or replaces an L-leucine. PubMed:18688235 DiffAvg: -113.16 DiffFormula: C -6 H -11 N -1 O -1 DiffMono: -113.084064 Formula: none MassAvg: none MassMono: none Origin: L Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01642 This represents the loss or replacement of an L-lysine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-lysine removal MOD:01642 A protein modification that effectively removes or replaces an L-lysine. PubMed:18688235 DiffAvg: -128.18 DiffFormula: C -6 H -12 N -2 O -1 DiffMono: -128.094963 Formula: none MassAvg: none MassMono: none Origin: K Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: ntermmcleave PSI-MOD Met-loss MOD:01643 This represents the loss or replacement of an L-methionine residue in a polypeptide, including initiator methionine removal in eukaryotes. It may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution [JSG]. L-methionine removal MOD:01643 A protein modification that effectively removes or replaces an L-methionine. OMSSA:9 PubMed:3327521 Unimod:765 DiffAvg: -131.19 DiffFormula: C -5 H -9 N -1 O -1 S -1 DiffMono: -131.040485 Formula: none MassAvg: none MassMono: none Origin: M Source: natural TermSpec: none Unimod: Unimod:765 ntermmcleave Met-loss A protein modification that effectively removes or replaces an L-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01644 This represents the loss or replacement of an L-phenylalanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-phenylalanine removal MOD:01644 A protein modification that effectively removes or replaces an L-phenylalanine. PubMed:18688235 DiffAvg: -147.18 DiffFormula: C -9 H -9 N -1 O -1 DiffMono: -147.068414 Formula: none MassAvg: none MassMono: none Origin: F Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01645 This represents the loss or replacement of an L-proline residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-proline removal MOD:01645 A protein modification that effectively removes or replaces an L-proline. PubMed:18688235 DiffAvg: -97.12 DiffFormula: C -5 H -7 N -1 O -1 DiffMono: -97.052764 Formula: none MassAvg: none MassMono: none Origin: P Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01646 This represents the loss or replacement of an L-serine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-serine removal MOD:01646 A protein modification that effectively removes or replaces an L-serine. PubMed:18688235 DiffAvg: -87.08 DiffFormula: C -3 H -5 N -1 O -2 DiffMono: -87.032028 Formula: none MassAvg: none MassMono: none Origin: S Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01647 This represents the loss or replacement of an L-threonine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-threonine removal MOD:01647 A protein modification that effectively removes or replaces an L-threonine. PubMed:18688235 DiffAvg: -101.10 DiffFormula: C -4 H -7 N -1 O -2 DiffMono: -101.047678 Formula: none MassAvg: none MassMono: none Origin: T Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01648 This represents the loss or replacement of an L-tryptophan residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-tryptophan removal MOD:01648 A protein modification that effectively removes or replaces an L-tryptophan. PubMed:18688235 DiffAvg: -186.21 DiffFormula: C -11 H -10 N -2 O -1 DiffMono: -186.079313 Formula: none MassAvg: none MassMono: none Origin: W Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01649 This represents the loss or replacement of an L-tyrosine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-tyrosine removal MOD:01649 A protein modification that effectively removes or replaces an L-tyrosine. PubMed:18688235 DiffAvg: -163.18 DiffFormula: C -9 H -9 N -1 O -2 DiffMono: -163.063329 Formula: none MassAvg: none MassMono: none Origin: Y Source: natural TermSpec: none A protein modification that effectively removes or replaces an L-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01650 This represents the loss or replacement of an L-valine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. L-valine removal MOD:01650 A protein modification that effectively removes or replaces an L-valine. PubMed:18688235 DiffAvg: -99.13 DiffFormula: C -5 H -9 N -1 O -1 DiffMono: -99.068414 Formula: none MassAvg: none MassMono: none Origin: V Source: natural TermSpec: none A protein modification that effectively removes a natural, standard, encoded residue. Origin: Source: TermSpec: PSI-MOD MOD:01651 This represents the loss of an encoded residue in a polypeptide. natural, standard, encoded residue removal MOD:01651 A protein modification that effectively removes a natural, standard, encoded residue. PubMed:18688235 Origin: X Source: natural TermSpec: none A protein modification that is produced by formation of an adduct with a sulfonyl halide compound used as a reagent. Origin: Source: TermSpec: PSI-MOD MOD:01652 These reagents typically react with N6-amino group of lysine residues and a free alpha-amino group of a peptide. sulfonyl halide reagent derivatized residue MOD:01652 A protein modification that is produced by formation of an adduct with a sulfonyl halide compound used as a reagent. PubMed:18688235 Origin: X Source: artifact TermSpec: none A protein modification that is produced by formation of an adduct with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Dansyl (Dns) DansylRes PSI-MOD 5-dimethylaminonaphthalene-1-sulfonyl Dansyl MOD:01653 dansyl chloride derivatized residue MOD:01653 A protein modification that is produced by formation of an adduct with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride. DeltaMass:0 Unimod:139 DiffAvg: 233.29 DiffFormula: C 12 H 11 N 1 O 2 S 1 DiffMono: 233.051050 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:139 Dansyl (Dns) DansylRes 5-dimethylaminonaphthalene-1-sulfonyl Dansyl A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form N6-Dansyl-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N6DansylLys PSI-MOD 5-dimethylaminonaphthalene-1-sulfonyl Dansyl MOD:01654 N6-Dansyl derivatized lysine MOD:01654 A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form N6-Dansyl-lysine. Unimod:139#K DiffAvg: 233.29 DiffFormula: C 12 H 11 N 1 O 2 S 1 DiffMono: 233.051050 Formula: C 18 H 23 N 3 O 3 S 1 MassAvg: 361.46 MassMono: 361.146013 Origin: K Source: artifact TermSpec: none Unimod: Unimod:139 N6DansylLys 5-dimethylaminonaphthalene-1-sulfonyl Dansyl A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form an alpha-amino-Dansyl-derivatized residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N2DansylRes PSI-MOD 5-dimethylaminonaphthalene-1-sulfonyl Dansyl MOD:01655 alpha-amino-Dansyl derivatized residue MOD:01655 A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form an alpha-amino-Dansyl-derivatized residue. Unimod:139#N-term DiffAvg: 233.29 DiffFormula: C 12 H 11 N 1 O 2 S 1 DiffMono: 233.051050 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:139 N2DansylRes 5-dimethylaminonaphthalene-1-sulfonyl Dansyl A protein modification that is produced by formation of an adduct with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, Dabsyl chloride. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl DabsylRes PSI-MOD MOD:01656 Dabsyl chloride derivatized residue MOD:01656 A protein modification that is produced by formation of an adduct with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, Dabsyl chloride. PubMed:18688235 DiffAvg: 287.34 DiffFormula: C 14 H 13 N 3 O 2 S 1 DiffMono: 287.072848 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none 4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl DabsylRes A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form N6-Dabsyl-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N6-[4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl]lysine N6DabsylLys PSI-MOD MOD:01657 N6-Dabsyl derivatized lysine MOD:01657 A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form N6-Dabsyl-lysine. PubMed:18688235 DiffAvg: 287.34 DiffFormula: C 14 H 13 N 3 O 2 S 1 DiffMono: 287.072848 Formula: C 20 H 25 N 5 O 3 S 1 MassAvg: 415.51 MassMono: 415.167811 Origin: K Source: artifact TermSpec: none N6-[4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl]lysine N6DabsylLys A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form an alpha-amino-Dabsyl-derivatized residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N2DabsylRes PSI-MOD MOD:01658 alpha-amino-Dabsyl derivatized residue MOD:01658 A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form an alpha-amino-Dabsyl-derivatized residue. PubMed:18688235 DiffAvg: 287.34 DiffFormula: C 14 H 13 N 3 O 2 S 1 DiffMono: 287.072848 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term N2DabsylRes A protein modification that is produced by formation of an adduct with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonic acid Uniblue A UniblueARes PSI-MOD MOD:01659 This reagent has a reactive sulfonyl vinyl and typically reacts with the free thiol group of cysteine residues. Uniblue A derivatized residue MOD:01659 A protein modification that is produced by formation of an adduct with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A. PubMed:18688235 DiffAvg: 484.50 DiffFormula: C 22 H 16 N 2 O 7 S 2 DiffMono: 484.039893 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonic acid Uniblue A UniblueARes A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A cysteine adduct. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate SUniblueACys Uniblue A PSI-MOD MOD:01660 Uniblue A derivatized cysteine MOD:01660 A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A cysteine adduct. PubMed:18688235 DiffAvg: 484.50 DiffFormula: C 22 H 16 N 2 O 7 S 2 DiffMono: 484.039893 Formula: C 25 H 21 N 3 O 8 S 3 MassAvg: 587.64 MassMono: 587.049078 Origin: C Source: artifact TermSpec: none 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate SUniblueACys Uniblue A A protein modification that effectively converts an L-tyrosine residue to pyruvic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0662 2-oxopropanoic acid MOD_RES Pyruvic acid (Tyr) pyruvic acid PSI-MOD MOD:01661 pyruvic acid (Tyr) MOD:01661 A protein modification that effectively converts an L-tyrosine residue to pyruvic acid. PubMed:10085076 PubMed:3042771 PubMed:500639 PubMed:8464063 RESID:AA0127#TYR DiffAvg: -93.13 DiffFormula: C -6 H -7 N -1 O 0 DiffMono: -93.057849 Formula: C 3 H 3 O 2 MassAvg: 71.06 MassMono: 71.013304 Origin: Y Source: natural TermSpec: N-term 2-oxopropanoic acid MOD_RES Pyruvic acid (Tyr) pyruvic acid A protein modification that effectively converts an L-glutamine residue to N5-(ADP-ribosyl)-L-glutamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-5-oxopentanoic acid N5-(ADP-ribosyl)-L-glutamine N5-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-glutamine N5-alpha-D-ribofuranosyl-L-glutamine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) PSI-MOD MOD:01662 N5-(ADP-ribosyl)-L-glutamine MOD:01662 A protein modification that effectively converts an L-glutamine residue to N5-(ADP-ribosyl)-L-glutamine. PubMed:20185726 RESID:AA0518 DiffAvg: 541.30 DiffFormula: C 15 H 21 N 5 O 13 P 2 DiffMono: 541.061109 Formula: C 20 H 29 N 7 O 15 P 2 MassAvg: 669.43 MassMono: 669.119687 Origin: Q Source: natural TermSpec: none (S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-5-oxopentanoic acid N5-(ADP-ribosyl)-L-glutamine N5-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-glutamine N5-alpha-D-ribofuranosyl-L-glutamine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) A protein modification that effectively converts an L-threonine residue to O-(ADP-ribosyl)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-butanoic acid O-(ADP-ribosyl)-L-threonine O3-(ADP-ribosyl)-L-threonine O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-threonine O3-alpha-D-ribofuranosyl-L-threonine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) PSI-MOD MOD:01663 O-(ADP-ribosyl)-L-threonine MOD:01663 A protein modification that effectively converts an L-threonine residue to O-(ADP-ribosyl)-L-threonine. PubMed:20185726 RESID:AA0519 DiffAvg: 541.30 DiffFormula: C 15 H 21 N 5 O 13 P 2 DiffMono: 541.061109 Formula: C 19 H 28 N 6 O 15 P 2 MassAvg: 642.41 MassMono: 642.108787 Origin: T Source: natural TermSpec: none (S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-butanoic acid O-(ADP-ribosyl)-L-threonine O3-(ADP-ribosyl)-L-threonine O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-threonine O3-alpha-D-ribofuranosyl-L-threonine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate) A protein modification that effectively converts an L-tryptophan residue to a 7'-hydroxy-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0427 (2S)-2-amino-3-(7-hydroxy-1H-indol-3-yl)propanoic acid 7'-hydroxy-L-tryptophan 7-hydroxy-L-tryptophan PSI-MOD MOD:01664 7'-hydroxy-L-tryptophan MOD:01664 A protein modification that effectively converts an L-tryptophan residue to a 7'-hydroxy-L-tryptophan. PubMed:20223990 RESID:AA0520 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 11 H 10 N 2 O 2 MassAvg: 202.21 MassMono: 202.074228 Origin: W Source: natural TermSpec: none (2S)-2-amino-3-(7-hydroxy-1H-indol-3-yl)propanoic acid 7'-hydroxy-L-tryptophan 7-hydroxy-L-tryptophan A protein modification that effectively crosslinks an N-terminal L-valine residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine. Origin: Source: TermSpec: (2S)-2-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]amino-3-methylbutanoic acid ACT_SITE Schiff-base intermediate with DNA; via amino nitrogen DNA glycosylase valine Schiff base intermediate N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine PSI-MOD MOD:01665 N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine MOD:01665 A protein modification that effectively crosslinks an N-terminal L-valine residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine. PubMed:20185759 RESID:AA0521 Origin: V Source: hypothetical TermSpec: N-term (2S)-2-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]amino-3-methylbutanoic acid ACT_SITE Schiff-base intermediate with DNA; via amino nitrogen DNA glycosylase valine Schiff base intermediate N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine A protein modification that is produced by formation of an adduct with epicocconone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (6S,9aS)-6-(hydroxymethyl)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-9a-methyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione Deep Purple LavaPurple Lightning Fast PSI-MOD MOD:01666 epicocconone derivatized residue MOD:01666 A protein modification that is produced by formation of an adduct with epicocconone. PubMed:18688235 DiffAvg: 410.42 DiffFormula: C 23 H 22 O 7 DiffMono: 410.136553 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none (6S,9aS)-6-(hydroxymethyl)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-9a-methyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione Deep Purple LavaPurple Lightning Fast A protein modification that is produced by formation of an adduct with epicocconone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (6Z,7aS)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-7a-methyl-6-[([(1S)-1-amino-1-carboxylpentyl]amino)methylidene]-5-[(2S)-2,3-dihydroxypropyl]-1-benzofuran-2,7(6H,7aH)-dione DeepPurple LavaPurple Lightning Fast PSI-MOD MOD:01667 N6-epicoccononyl lysine adduct MOD:01667 A protein modification that is produced by formation of an adduct with epicocconone. PubMed:18688235 DiffAvg: 410.42 DiffFormula: C 23 H 22 O 7 DiffMono: 410.136553 Formula: C 29 H 34 N 2 O 8 MassAvg: 538.60 MassMono: 538.231516 Origin: K Source: artifact TermSpec: none (6Z,7aS)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-7a-methyl-6-[([(1S)-1-amino-1-carboxylpentyl]amino)methylidene]-5-[(2S)-2,3-dihydroxypropyl]-1-benzofuran-2,7(6H,7aH)-dione DeepPurple LavaPurple Lightning Fast A protein modification that effectively converts an L-aspartic acid residue to O4-(8alpha-FAD)-L-aspartate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-oxo-4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxybutanoic acid 8alpha-[(4-aspartyl)oxy]FAD O4-(8alpha-FAD)-L-aspartate PSI-MOD MOD:01668 O4-(8alpha-FAD)-L-aspartate MOD:01668 A protein modification that effectively converts an L-aspartic acid residue to O4-(8alpha-FAD)-L-aspartate. PubMed:20080101 RESID:AA0522 DiffAvg: 783.54 DiffFormula: C 27 H 31 N 9 O 15 P 2 DiffMono: 783.141485 Formula: C 31 H 36 N 10 O 18 P 2 MassAvg: 898.63 MassMono: 898.168428 Origin: D Source: natural TermSpec: none (2S)-2-amino-4-oxo-4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxybutanoic acid 8alpha-[(4-aspartyl)oxy]FAD O4-(8alpha-FAD)-L-aspartate A protein modification that effectively converts an L-arginine residue to N(omega),N(omega),N'(omega)-trimethyl-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-5-([(dimethylamino)(methylamino)methylidene]amino)pentanoic acid (2S)-2-amino-5-([(dimethylamino)(methylimino)methyl]amino)pentanoic acid 2-[(4S)-4-amino-5-oxopentyl]-1,1,3-trimethylguanidine N(G)-trimethylarginine N5-[(dimethylamino)(imino)methyl]ornithine NoNoNo'Me3Arg omega-N,omega-N,omega-N'-trimethyl-L-arginine trimethylationr PSI-MOD Trimethyl tri-Methylation MOD:01669 trimethyl-L-arginine MOD:01669 A protein modification that effectively converts an L-arginine residue to N(omega),N(omega),N'(omega)-trimethyl-L-arginine. OMSSA:117 PubMed:11704273 PubMed:602668 RESID:AA0523 Unimod:37#R DiffAvg: 42.08 DiffFormula: C 3 H 6 N 0 O 0 DiffMono: 42.046950 Formula: C 9 H 18 N 4 O 1 MassAvg: 198.27 MassMono: 198.148061 Origin: R Source: hypothetical TermSpec: none Unimod: Unimod:37 (2S)-2-amino-5-([(dimethylamino)(methylamino)methylidene]amino)pentanoic acid (2S)-2-amino-5-([(dimethylamino)(methylimino)methyl]amino)pentanoic acid 2-[(4S)-4-amino-5-oxopentyl]-1,1,3-trimethylguanidine N(G)-trimethylarginine N5-[(dimethylamino)(imino)methyl]ornithine NoNoNo'Me3Arg omega-N,omega-N,omega-N'-trimethyl-L-arginine trimethylationr Trimethyl tri-Methylation A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-(chloroamino)hexanoic acid N(zeta)-chlorolysine N6-chloro-L-lysine N6ClLys epsilon-chlorolysine lysine chloramine PSI-MOD MOD:01670 N6-chloro-L-lysine MOD:01670 A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. PubMed:16091367 PubMed:16195462 PubMed:17260957 RESID:AA0524 DiffAvg: 34.44 DiffFormula: C 0 Cl 1 H -1 N 0 O 0 DiffMono: 33.961028 Formula: C 6 Cl 1 H 11 N 2 O 1 MassAvg: 162.62 MassMono: 162.055991 Origin: K Source: hypothetical TermSpec: none (2S)-2-amino-6-(chloroamino)hexanoic acid N(zeta)-chlorolysine N6-chloro-L-lysine N6ClLys epsilon-chlorolysine lysine chloramine A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using free L-asparagine and releasing ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid ACT_SITE O-isoaspartyl threonine intermediate O(beta)-(beta-aspartyl)threonine O-(L-isoaspartyl)-L-threonine O3-(isoaspartyl)-threonine PSI-MOD MOD:01671 This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. O-(L-isoaspartyl)-L-threonine (active site intermediate) MOD:01671 A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using free L-asparagine and releasing ammonia. PubMed:8706862 RESID:AA0525#THR DiffAvg: 115.09 DiffFormula: C 4 H 5 N 1 O 3 DiffMono: 115.026943 Formula: C 8 H 12 N 2 O 5 MassAvg: 216.19 MassMono: 216.074621 Origin: T Source: natural TermSpec: none (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid ACT_SITE O-isoaspartyl threonine intermediate O(beta)-(beta-aspartyl)threonine O-(L-isoaspartyl)-L-threonine O3-(isoaspartyl)-threonine A protein modification that effectively substitutes a hydrogen atom of an L-lysine residue with a halogen atom. Origin: Source: TermSpec: PSI-MOD MOD:01672 halogenated lysine MOD:01672 A protein modification that effectively substitutes a hydrogen atom of an L-lysine residue with a halogen atom. PubMed:18688235 Origin: K Source: none TermSpec: none A protein modification that effectively replaces a hydrogen atom with an N-acetylaminohexose group through a glycosidic bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: HexNAcRes PSI-MOD HexNAc N-Acetylhexosamine MOD:01673 N-acetylaminohexosylated residue MOD:01673 A protein modification that effectively replaces a hydrogen atom with an N-acetylaminohexose group through a glycosidic bond. Unimod:43 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:43 HexNAcRes HexNAc N-Acetylhexosamine A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminohexosyl)-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)amino-4-oxobutanoic acid HexNAcAsn N4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-asparagine N4-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-asparagine N4-(N-acetylhexosaminyl)asparagine N4-asparagine-beta-N-acetylhexosaminide N4-glycosyl-L-asparagine N4-glycosylasparagine N4HexNAcAsn hexNAcN PSI-MOD HexNAc N-Acetylhexosamine MOD:01674 N4-(N-acetylamino)hexosyl-L-asparagine MOD:01674 A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminohexosyl)-L-asparagine. OMSSA:182 Unimod:43#N DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 12 H 19 N 3 O 7 MassAvg: 317.30 MassMono: 317.122300 Origin: N Source: natural TermSpec: none Unimod: Unimod:43 (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)amino-4-oxobutanoic acid HexNAcAsn N4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-asparagine N4-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-asparagine N4-(N-acetylhexosaminyl)asparagine N4-asparagine-beta-N-acetylhexosaminide N4-glycosyl-L-asparagine N4-glycosylasparagine N4HexNAcAsn hexNAcN HexNAc N-Acetylhexosamine A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminohexosyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-hexopyranosyloxy)propanoic acid O-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-serine O-(N-acetylhexosaminyl)serine O-glycosylserine O-seryl-beta-N-acetylhexosaminide O3-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-serine OHexNAcSer hexNAcS PSI-MOD HexNAc N-Acetylhexosamine MOD:01675 O-(N-acetylamino)hexosyl-L-serine MOD:01675 A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminohexosyl)-L-serine. OMSSA:184 Unimod:43#S DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 11 H 18 N 2 O 7 MassAvg: 290.27 MassMono: 290.111401 Origin: S Source: natural TermSpec: none Unimod: Unimod:43 (S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-hexopyranosyloxy)propanoic acid O-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-serine O-(N-acetylhexosaminyl)serine O-glycosylserine O-seryl-beta-N-acetylhexosaminide O3-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-serine OHexNAcSer hexNAcS HexNAc N-Acetylhexosamine A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminohexosyl)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S,3R)-2-amino-3-(alpha-D-2-acetamido-2-deoxyhexopyranosyloxy)butanoic acid O-(N-acetylhexcosaminyl)-L-threonine O-glycosylthreonine O3-(N-acetylhexosaminyl)threonine OHexNAcThr hexNAcT PSI-MOD HexNAc N-Acetylhexosamine MOD:01676 O-(N-acetylamino)hexosyl-L-threonine MOD:01676 A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminohexosyl)-L-threonine. OMSSA:185 Unimod:43#T DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 12 H 20 N 2 O 7 MassAvg: 304.30 MassMono: 304.127051 Origin: T Source: natural TermSpec: none Unimod: Unimod:43 (2S,3R)-2-amino-3-(alpha-D-2-acetamido-2-deoxyhexopyranosyloxy)butanoic acid O-(N-acetylhexcosaminyl)-L-threonine O-glycosylthreonine O3-(N-acetylhexosaminyl)threonine OHexNAcThr hexNAcT HexNAc N-Acetylhexosamine A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)hexosyl-L-hydroxyproline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-hexopyranosyloxy]pyrrolidine-2-carboxylic acid 4-(N-acetylhexosaminyloxy)proline 4-[(2-N-acetylamino)-alpha-D-hexopyranosyl]oxyproline O4-glycosyl-hydroxyproline O4HexNAcHyPro alpha-2-(N-acetylamino)hexopyranosyl-4-hydroxyproline PSI-MOD HexNAc MOD:01677 secondary to RESID:AA0030 O4-(N-acetylamino)hexosyl-L-hydroxyproline MOD:01677 A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)hexosyl-L-hydroxyproline. PubMed:18688235 DiffAvg: 219.19 DiffFormula: C 8 H 13 N 1 O 6 DiffMono: 219.074287 Formula: C 13 H 20 N 2 O 7 MassAvg: 316.31 MassMono: 316.127051 Origin: P Source: natural TermSpec: none (2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-hexopyranosyloxy]pyrrolidine-2-carboxylic acid 4-(N-acetylhexosaminyloxy)proline 4-[(2-N-acetylamino)-alpha-D-hexopyranosyl]oxyproline O4-glycosyl-hydroxyproline O4HexNAcHyPro alpha-2-(N-acetylamino)hexopyranosyl-4-hydroxyproline HexNAc A protein modification that effectively coverts L-lysine to N6-carbamoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0675 2-amino-6-ureido-hexanoic acid MOD_RES N6-carbamoyllysine N6-(aminocarbonyl)-L-lysine N6CbmLys carbamylk homocitrulline PSI-MOD Carbamyl Carbamylation MOD:01678 This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation in solution [JSG]. N6-carbamoyl-L-lysine MOD:01678 A protein modification that effectively coverts L-lysine to N6-carbamoyl-L-lysine. ChEBI:144369 DeltaMass:56 OMSSA:31 PubMed:10978403 PubMed:12203680 Unimod:5#K DiffAvg: 43.02 DiffFormula: C 1 H 1 N 1 O 1 DiffMono: 43.005814 Formula: C 7 H 13 N 3 O 2 MassAvg: 171.20 MassMono: 171.100777 Origin: K Source: artifact TermSpec: none Unimod: Unimod:5 2-amino-6-ureido-hexanoic acid MOD_RES N6-carbamoyllysine N6-(aminocarbonyl)-L-lysine N6CbmLys carbamylk homocitrulline Carbamyl Carbamylation A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a carbamoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N2CbmRes ntermcarbamyl PSI-MOD Carbamyl Carbamylation MOD:01679 This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation. This modification effectively blocks Edman degradation, and because it can dehydrate to a cyanate group and react with another peptide N-terminal, it can effectively block two peptide molecules [JSG]. alpha-aminocarbamoylated residue MOD:01679 A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a carbamoyl group. DeltaMass:56 OMSSA:32 PubMed:10978403 PubMed:12203680 Unimod:5#N-term DiffAvg: 43.02 DiffFormula: C 1 H 1 N 1 O 1 DiffMono: 43.005814 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:5 N2CbmRes ntermcarbamyl Carbamyl Carbamylation A protein modification that effectively replaces one residue alpha amino or imino hydrogen with one methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N2Me1Res ntermmethyl ntermpepmethyl PSI-MOD Methyl Methylation MOD:01680 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. alpha-amino monomethylated residue MOD:01680 A protein modification that effectively replaces one residue alpha amino or imino hydrogen with one methyl group. OMSSA:11 OMSSA:76 Unimod:34#N-term DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: N-term Unimod: Unimod:34 N2Me1Res ntermmethyl ntermpepmethyl Methyl Methylation A protein modification that effectively replaces one hydrogen atom of an L-aspartic acid residue with one methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Me1Asp methyld PSI-MOD Methyl Methylation MOD:01681 monomethylated L-aspartic acid MOD:01681 A protein modification that effectively replaces one hydrogen atom of an L-aspartic acid residue with one methyl group. OMSSA:16 Unimod:34#D DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 5 H 7 N 1 O 3 MassAvg: 129.12 MassMono: 129.042593 Origin: D Source: artifact TermSpec: none Unimod: Unimod:34 Me1Asp methyld Methyl Methylation A protein modification that effectively replaces one hydrogen atom of an L-cysteine residue with one methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Me1Cys methylc PSI-MOD Methyl Methylation MOD:01682 monomethylated L-cysteine MOD:01682 A protein modification that effectively replaces one hydrogen atom of an L-cysteine residue with one methyl group. OMSSA:73 Unimod:34#C DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 4 H 7 N 1 O 1 S 1 MassAvg: 117.17 MassMono: 117.024835 Origin: C Source: natural TermSpec: none Unimod: Unimod:34 Me1Cys methylc Methyl Methylation A protein modification that effectively replaces one hydrogen atom of an L-lysine residue with one methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Me1Lys methylk PSI-MOD Methyl Methylation MOD:01683 monomethylated L-lysine MOD:01683 A protein modification that effectively replaces one hydrogen atom of an L-lysine residue with one methyl group. OMSSA:0 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 15 N 2 O 2 MassAvg: 159.21 MassMono: 159.113353 Origin: K Source: natural TermSpec: none Me1Lys methylk Methyl Methylation A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Hexadecanoylated L-cysteine PamCys palmitoylationc PSI-MOD Palmitoyl Palmitoylation MOD:01684 palmitoylated-L-cysteine MOD:01684 A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine. OMSSA:92 Unimod:47 DiffAvg: 238.41 DiffFormula: C 16 H 30 N 0 O 1 S 0 DiffMono: 238.229666 Formula: C 19 H 35 N 1 O 2 S 1 MassAvg: 341.55 MassMono: 341.238850 Origin: C Source: natural TermSpec: none Unimod: Unimod:47 Hexadecanoylated L-cysteine PamCys palmitoylationc Palmitoyl Palmitoylation A protein modification that effectively replaces a residue alpha-amino group with a alpha-palmitoylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N2PamRes PSI-MOD Palmitoyl Palmitoylation MOD:01685 alpha-amino palmitoylated residue MOD:01685 A protein modification that effectively replaces a residue alpha-amino group with a alpha-palmitoylamino group. Unimod:47#N-term DiffAvg: 238.41 DiffFormula: C 16 H 30 N 0 O 1 S 0 DiffMono: 238.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: N-term Unimod: Unimod:47 N2PamRes Palmitoyl Palmitoylation A protein modification that effectively replaces two alpha amino hydrogen atoms with two methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N2Me2Res ntermpepdimethyl PSI-MOD Dimethyl di-Methylation MOD:01686 For alpha-amino acids, both N-alpha-monomethylation and complete N-alpha protonation and trimethylation have been observed, but incomplete dimethylation has not been reported as a natural process. For N-terminal proline residues, dimethylation can only be effectively accomplished with a protonated imino group, whereas this process accounts only for dimethylation and not protonation. See MOD:00889. alpha-amino dimethylated residue MOD:01686 A protein modification that effectively replaces two alpha amino hydrogen atoms with two methyl group. OMSSA:38 Unimod:36#N-term DiffAvg: 28.05 DiffFormula: C 2 H 4 DiffMono: 28.031300 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: N-term Unimod: Unimod:36 N2Me2Res ntermpepdimethyl Dimethyl di-Methylation A protein modification that effectively replaces an alpha-aminium group with a trimethylaminium group. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: N2Me3Res ntermtrimethyl PSI-MOD Trimethyl tri-Methylation MOD:01687 For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Res process (MOD:01698) accounts for both protonation and trimethylation. alpha-amino trimethylated residue MOD:01687 A protein modification that effectively replaces an alpha-aminium group with a trimethylaminium group. OMSSA:12 Unimod:37#N-term DiffAvg: 42.08 DiffFormula: C 3 H 6 N 0 O 0 DiffMono: 42.046402 FormalCharge: 1+ Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: N-term Unimod: Unimod:37 N2Me3Res ntermtrimethyl Trimethyl tri-Methylation A protein modification that effectively converts an L-asparagine residue to one of the diastereomeric 3-hydroxy-L-asparagine residues. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3HyAsn hydroxylationn monohydroxylated asparagine PSI-MOD Oxidation MOD:01688 3-hydroxy-L-asparagine MOD:01688 A protein modification that effectively converts an L-asparagine residue to one of the diastereomeric 3-hydroxy-L-asparagine residues. OMSSA:61 Unimod:35#N DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 4 H 6 N 2 O 3 MassAvg: 130.10 MassMono: 130.037842 Origin: N Source: natural TermSpec: none Unimod: Unimod:35 3HyAsn hydroxylationn monohydroxylated asparagine Oxidation A protein modification that effectively converts a carboxyl-terminal residue to an alpha-carboxyl (1-carboxyl) methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: C1OMeRes ctermpepmeester ctermpepmethyl PSI-MOD Methyl MOD:01689 alpha-carboxyl methylated residue MOD:01689 A protein modification that effectively converts a carboxyl-terminal residue to an alpha-carboxyl (1-carboxyl) methyl ester. OMSSA:18 OMSSA:68 Unimod:34#C-term DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 S 0 DiffMono: 14.015650 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: C-term Unimod: Unimod:34 C1OMeRes ctermpepmeester ctermpepmethyl Methyl Methyl A protein modification that effectively converts an L-cysteine residue to N-[(12R)-12-hydroxymyristoyl]-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0419 2-[(12R)-12-hydroxytetradecanoyl]amino-3-sulfanylpropanoic acid LIPID N-[(12R)-12-hydroxymyristoyl]cysteine N-[(12R)-12-hydroxymyristoyl]-L-cysteine N-[(12R)-12-hydroxytetradecanoyl]cysteine PSI-MOD MOD:01690 N-[(12R)-12-hydroxymyristoyl]-L-cysteine MOD:01690 A protein modification that effectively converts an L-cysteine residue to N-[(12R)-12-hydroxymyristoyl]-L-cysteine. RESID:AA0516 DiffAvg: 226.36 DiffFormula: C 14 H 26 N 0 O 2 S 0 DiffMono: 226.193280 Formula: C 17 H 32 N 1 O 3 S 1 MassAvg: 330.51 MassMono: 330.210290 Origin: C Source: natural TermSpec: N-term 2-[(12R)-12-hydroxytetradecanoyl]amino-3-sulfanylpropanoic acid LIPID N-[(12R)-12-hydroxymyristoyl]cysteine N-[(12R)-12-hydroxymyristoyl]-L-cysteine N-[(12R)-12-hydroxytetradecanoyl]cysteine A protein modification that effectively converts an L-cysteine residue to N-(12-ketomyristoyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0420 2-(12-oxotetradecanoyl)amino-3-sulfanylpropanoic acid LIPID N-(12-oxomyristoyl)cysteine N-(12-ketomyristoyl)-L-cysteine N-(12-oxotetradecanoyl)cysteine PSI-MOD MOD:01691 N-(12-ketomyristoyl)-L-cysteine MOD:01691 A protein modification that effectively converts an L-cysteine residue to N-(12-ketomyristoyl)-L-cysteine. PubMed:19053188 RESID:AA0517 DiffAvg: 224.34 DiffFormula: C 14 H 24 N 0 O 2 S 0 DiffMono: 224.177630 Formula: C 17 H 30 N 1 O 3 S 1 MassAvg: 328.49 MassMono: 328.194640 Origin: C Source: natural TermSpec: N-term 2-(12-oxotetradecanoyl)amino-3-sulfanylpropanoic acid LIPID N-(12-oxomyristoyl)cysteine N-(12-ketomyristoyl)-L-cysteine N-(12-oxotetradecanoyl)cysteine A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl semialdehyde. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: gamma-glutamyl semialdehyde glutamyl 5-semialdehyde glutamyl aldehyde PSI-MOD Deoxy MOD:01692 glutamyl semialdehyde (Glu) MOD:01692 A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl semialdehyde. PubMed:18688235 PubMed:743268 DiffAvg: -16.00 DiffFormula: C 0 H 0 N 0 O -1 DiffMono: -15.994915 Formula: C 5 H 7 N 1 O 2 MassAvg: 113.12 MassMono: 113.047678 Origin: E Source: artifact TermSpec: none gamma-glutamyl semialdehyde glutamyl 5-semialdehyde glutamyl aldehyde Deoxy A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a (pyrid-3-yl)acetyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: ntermpeppyridyl PSI-MOD Pyridylacetyl pyridylacetyl MOD:01693 Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG]. alpha-amino pyridylacetylated residue MOD:01693 A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a (pyrid-3-yl)acetyl group. OMSSA:107 PubMed:9276974 Unimod:25#N-term DiffAvg: 119.12 DiffFormula: C 7 H 5 N 1 O 1 DiffMono: 119.037114 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:25 ntermpeppyridyl Pyridylacetyl pyridylacetyl A protein modification that effectively results from forming an adduct between an L-cysteine residue and the bioluminescent compound didehydrocoelenterazine to form S-(coelenterazin-3a-yl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0428 (2R)-2-amino-3-([(4-hydroxyphenyl)(8-benzyl-3-oxo-6-[4-hydroxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)methyl]sulfanyl)propanoic acid MOD_RES S-(coelenterazin-3a-yl)cysteine S-(coelenterazin-3a-yl)-L-cysteine dehydrocoelenterazine cysteine adduct symplectin chromophore PSI-MOD MOD:01694 S-(coelenterazin-3a-yl)-L-cysteine MOD:01694 A protein modification that effectively results from forming an adduct between an L-cysteine residue and the bioluminescent compound didehydrocoelenterazine to form S-(coelenterazin-3a-yl)-L-cysteine. ChEBI:2311 PubMed:18997450 RESID:AA0526 DiffAvg: 421.46 DiffFormula: C 26 H 19 N 3 O 3 S 0 DiffMono: 421.142641 Formula: C 29 H 24 N 4 O 4 S 1 MassAvg: 524.60 MassMono: 524.151826 Origin: C Source: natural TermSpec: none (2R)-2-amino-3-([(4-hydroxyphenyl)(8-benzyl-3-oxo-6-[4-hydroxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)methyl]sulfanyl)propanoic acid MOD_RES S-(coelenterazin-3a-yl)cysteine S-(coelenterazin-3a-yl)-L-cysteine dehydrocoelenterazine cysteine adduct symplectin chromophore A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 3-(carboxamidomethylthio)propanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 3-(carbamidomethylthio)propanoyl CAMthiopropanoyl MOD:01695 alpha-amino 3-(carboxamidomethylthio)propanoylated residue MOD:01695 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 3-(carboxamidomethylthio)propanoyl group. PubMed:15121203 Unimod:293#N-term DiffAvg: 145.18 DiffFormula: C 5 H 7 N 1 O 2 S 1 DiffMono: 145.019749 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:293 3-(carbamidomethylthio)propanoyl CAMthiopropanoyl A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group. Origin: Source: TermSpec: PSI-MOD MOD:01696 alpha-amino acylated residue MOD:01696 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group. PubMed:18688235 Origin: X Source: natural TermSpec: N-term A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 4-(2-aminoethyl)benzenesulfonyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD AEBS Aminoethylbenzenesulfonylation MOD:01697 See the comment for MOD:00596 [JSG]. alpha-amino 4-(2-aminoethyl)benzenesulfonylated residue MOD:01697 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 4-(2-aminoethyl)benzenesulfonyl group. DeltaMass:235 PubMed:8597590 Unimod:276#N-term DiffAvg: 183.23 DiffFormula: C 8 H 9 N 1 O 2 S 1 DiffMono: 183.035400 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:276 AEBS Aminoethylbenzenesulfonylation A protein modification that effectively replaces an amino group with a trimethylaminium group. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N2Me3+Res PSI-MOD Trimethyl tri-Methylation MOD:01698 alpha-amino trimethylated protonated-residue MOD:01698 A protein modification that effectively replaces an amino group with a trimethylaminium group. PubMed:18688235 DiffAvg: 43.09 DiffFormula: C 3 H 7 N 0 O 0 S 0 DiffMono: 43.054227 FormalCharge: 1+ Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: N-term N2Me3+Res Trimethyl tri-Methylation A protein modification that effectively adds a hydrogen cation, a proton, forming a cationic residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: H+NRes PSI-MOD MOD:01699 protonated residue MOD:01699 A protein modification that effectively adds a hydrogen cation, a proton, forming a cationic residue. PubMed:18688235 DiffAvg: 1.01 DiffFormula: C 0 H 1 N 0 O 0 DiffMono: 1.007276 FormalCharge: 1+ Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none H+NRes A protein modification that effectively adds a proton to a residue alpha-amnino or alpha-imino group forming an alpha-aminium or alpha-iminium group, respectively. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N2H+NRes PSI-MOD MOD:01700 alpha-amino protonated residue MOD:01700 A protein modification that effectively adds a proton to a residue alpha-amnino or alpha-imino group forming an alpha-aminium or alpha-iminium group, respectively. PubMed:18688235 DiffAvg: 1.01 DiffFormula: C 0 H 1 N 0 O 0 DiffMono: 1.007276 FormalCharge: 1+ Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: N-term N2H+NRes A protein modification that effectively removes a hydrogen cation, a proton, forming an anionic residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: H-NRes PSI-MOD MOD:01701 deprotonated residue MOD:01701 A protein modification that effectively removes a hydrogen cation, a proton, forming an anionic residue. PubMed:18688235 DiffAvg: -1.01 DiffFormula: C 0 H -1 N 0 O 0 DiffMono: -1.007276 FormalCharge: 1- Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none H-NRes A protein modification that effectively removes a proton from a residue 1-carboxyl group (referred to as the alpha-carboxyl), forming a carboxylate anion. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: C1H-NRes PSI-MOD MOD:01702 alpha-carboxyl deprotonated residue MOD:01702 A protein modification that effectively removes a proton from a residue 1-carboxyl group (referred to as the alpha-carboxyl), forming a carboxylate anion. PubMed:18688235 DiffAvg: -1.01 DiffFormula: C 0 H -1 N 0 O 0 DiffMono: -1.007276 FormalCharge: 1- Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: C-term C1H-NRes A protein modification that effectively converts a source amino acid residue to dehydrobutyrine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Dehydroamino butyric acid beta-elim-t dHAbu dehydro phospholosst PSI-MOD Dehydrated Dehydration MOD:01703 dehydrobutyrine MOD:01703 A protein modification that effectively converts a source amino acid residue to dehydrobutyrine. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 4 H 5 N 1 O 1 MassAvg: 83.09 MassMono: 83.037114 Origin: X Source: none TermSpec: none Dehydroamino butyric acid beta-elim-t dHAbu dehydro phospholosst Dehydrated Dehydrated Dehydration A protein modification that effectively converts an L-methionine residue to dehydrobutyrine, by neutral loss of methyl sulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: dHAbu(Met) PSI-MOD MOD:01704 It is expected that this neutral loss will produce a mix of (E)- and (Z)-isomers [JSG]. dehydrobutyrine (Met) MOD:01704 A protein modification that effectively converts an L-methionine residue to dehydrobutyrine, by neutral loss of methyl sulfide. PubMed:18688235 DiffAvg: -48.10 DiffFormula: C -1 H -4 N 0 O 0 S -1 DiffMono: -48.003371 Formula: C 4 H 5 N 1 O 1 MassAvg: 83.09 MassMono: 83.037114 Origin: M Source: artifact TermSpec: none dHAbu(Met) A protein modification that effectively replaces a residue hydrogen with an isotope tagged reagent acyl group. Origin: Source: TermSpec: PSI-MOD MOD:01705 isotope tagged reagent acylated residue MOD:01705 A protein modification that effectively replaces a residue hydrogen with an isotope tagged reagent acyl group. PubMed:18688235 Origin: X Source: artifact TermSpec: none A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group. Origin: Source: TermSpec: PSI-MOD MOD:01706 isotope tagged reagent N-acylated residue MOD:01706 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group. PubMed:18688235 Origin: X Source: artifact TermSpec: none A protein modification that effectively replaces a residue hydroxyl group with an isotope tagged reagent acyloxy group. Origin: Source: TermSpec: PSI-MOD MOD:01707 isotope tagged reagent O-acylated residue MOD:01707 A protein modification that effectively replaces a residue hydroxyl group with an isotope tagged reagent acyloxy group. PubMed:18688235 Origin: X Source: artifact TermSpec: none A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group. Origin: Source: TermSpec: PSI-MOD MOD:01708 isotope tagged reagent alpha-amino acylated residue MOD:01708 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group. PubMed:18688235 Origin: X Source: artifact TermSpec: N-term A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01709 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex reporter+balance reagent N-acylated residue MOD:01709 A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01710 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex reporter+balance reagent N-acylated residue MOD:01710 A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01711 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex reporter+balance reagent acylated N-terminal MOD:01711 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. Unimod:214#N-term DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:214 (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01712 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex reporter+balance reagent acylated N-terminal MOD:01712 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups. Unimod:214#N-term DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:214 (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance acyloxy groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01713 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ4plex reporter+balance reagent O-acylated residue MOD:01713 A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance acyloxy groups. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance acyloxy groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD MOD:01714 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. iTRAQ8plex reporter+balance reagent O-acylated residue MOD:01714 A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance acyloxy groups. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl A protein modification that effectively replaces a hydrogen atom of a residue with a Proteome Sciences TMT6plex reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01715 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex reporter+balance reagent acylated residue MOD:01715 A protein modification that effectively replaces a hydrogen atom of a residue with a Proteome Sciences TMT6plex reporter+balance group. Unimod:214 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:214 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue. 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex reporter fragment PSI-MOD MOD:01716 TMT6plex reporter fragment MOD:01716 The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue. PubMed:18688235 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex reporter fragment A protein modification that effectively replaces a residue amino- or imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01717 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex reporter+balance reagent N-acylated residue MOD:01717 A protein modification that effectively replaces a residue amino- or imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01718 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex reporter+balance reagent acylated N-terminal MOD:01718 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group. Unimod:214#N-term DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:214 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a residue hydroxyl with one of the Proteome Sciences TMT6plex reagent reporter+balance acyloxy groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01719 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex reporter+balance reagent O-acylated residue MOD:01719 A protein modification that effectively replaces a residue hydroxyl with one of the Proteome Sciences TMT6plex reagent reporter+balance acyloxy groups. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-126 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01720 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-126 reporter+balance reagent acylated residue MOD:01720 A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-126 reporter+balance group. Unimod:737 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-126 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01721 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-126 reporter+balance reagent acylated N-terminal MOD:01721 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-126 reporter+balance group. Unimod:737#N-term DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01722 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-126 reporter+balance reagent N6-acylated lysine MOD:01722 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. Unimod:737#K DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg: 357.26 MassMono: 357.257895 Origin: K Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01723 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-126 reporter+balance reagent O4'-acylated tyrosine MOD:01723 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. Unimod:737#Y DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg: 392.23 MassMono: 392.226261 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01724 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-126 reporter+balance reagent N'-acylated histidine MOD:01724 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg: 366.22 MassMono: 366.221844 Origin: H Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01725 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-126 reporter+balance reagent O3-acylated serine MOD:01725 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg: 316.19 MassMono: 316.194961 Origin: S Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01726 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-126 reporter+balance reagent O3-acylated threonine MOD:01726 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-126 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg: 330.21 MassMono: 330.210611 Origin: T Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-126 reporter fragment PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01727 TMT6plex-126 reporter fragment MOD:01727 The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 8 H 16 (14)N 1 MassAvg: 126.13 MassMono: 126.127726 Origin: X Source: artifact TermSpec: none 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-126 reporter fragment Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-127 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01728 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-127 reporter+balance reagent acylated residue MOD:01728 A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-127 reporter+balance group. Unimod:737 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-127 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01729 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-127 reporter+balance reagent acylated N-terminal MOD:01729 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-127 reporter+balance group. Unimod:737#N-term DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01730 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-127 reporter+balance reagent N6-acylated lysine MOD:01730 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. Unimod:737#K DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg: 357.26 MassMono: 357.257895 Origin: K Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01731 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-127 reporter+balance reagent O4'-acylated tyrosine MOD:01731 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. Unimod:737#Y DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 MassAvg: 229.16 MassMono: 229.162932 Origin: Y Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01732 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-127 reporter+balance reagent N'-acylated histidine MOD:01732 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg: 366.22 MassMono: 366.221844 Origin: H Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01733 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-127 reporter+balance reagent O3-acylated serine MOD:01733 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg: 316.19 MassMono: 316.194961 Origin: S Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01734 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-127 reporter+balance reagent O3-acylated threonine MOD:01734 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-127 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg: 330.21 MassMono: 330.210611 Origin: T Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-127 reagent acylated residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-127 reporter fragment PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01735 TMT6plex-127 reporter fragment MOD:01735 The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-127 reagent acylated residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 7 (13)C 1 H 16 (14)N 1 MassAvg: 127.13 MassMono: 127.131081 Origin: X Source: artifact TermSpec: none 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-127 reporter fragment Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-128 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01736 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-128 reporter+balance reagent acylated residue MOD:01736 A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-128 reporter+balance group. Unimod:737 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-128 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01737 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-128 reporter+balance reagent acylated N-terminal MOD:01737 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-128 reporter+balance group. Unimod:737#N-term DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01738 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-128 reporter+balance reagent N6-acylated lysine MOD:01738 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. Unimod:737#K DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg: 357.26 MassMono: 357.257895 Origin: K Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01739 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-128 reporter+balance reagent O4'-acylated tyrosine MOD:01739 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. Unimod:737#Y DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg: 392.23 MassMono: 392.226261 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01740 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-128 reporter+balance reagent N'-acylated histidine MOD:01740 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg: 366.22 MassMono: 366.221844 Origin: H Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01741 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-128 reporter+balance reagent O3-acylated serine MOD:01741 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg: 316.19 MassMono: 316.194961 Origin: S Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01742 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-128 reporter+balance reagent O3-acylated threonine MOD:01742 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-128 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg: 330.21 MassMono: 330.210611 Origin: T Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-128 reagent acylated residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-128 reporter fragment PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01743 TMT6plex-128 reporter fragment MOD:01743 The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-128 reagent acylated residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 6 (13)C 2 H 16 (14)N 1 MassAvg: 128.13 MassMono: 128.134436 Origin: X Source: artifact TermSpec: none 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-128 reporter fragment Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-129 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01744 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-129 reporter+balance reagent acylated residue MOD:01744 A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-129 reporter+balance group. Unimod:737 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-129 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01745 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-129 reporter+balance reagent acylated N-terminal MOD:01745 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-129 reporter+balance group. Unimod:737#N-term DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01746 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-129 reporter+balance reagent N6-acylated lysine MOD:01746 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. Unimod:737#K DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg: 357.26 MassMono: 357.257895 Origin: K Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01747 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-129 reporter+balance reagent O4'-acylated tyrosine MOD:01747 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. Unimod:737#Y DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg: 392.23 MassMono: 392.226261 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01748 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-129 reporter+balance reagent N'-acylated histidine MOD:01748 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg: 366.22 MassMono: 366.221844 Origin: H Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01749 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-129 reporter+balance reagent O3-acylated serine MOD:01749 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg: 316.19 MassMono: 316.194961 Origin: S Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01750 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-129 reporter+balance reagent O3-acylated threonine MOD:01750 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-129 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg: 330.21 MassMono: 330.210611 Origin: T Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-129 reagent acylated residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-129 reporter fragment PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01751 TMT6plex-129 reporter fragment MOD:01751 The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-129 reagent acylated residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 5 (13)C 3 H 16 (14)N 1 MassAvg: 129.14 MassMono: 129.137790 Origin: X Source: artifact TermSpec: none 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-129 reporter fragment Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-130 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01752 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-130 reporter+balance reagent acylated residue MOD:01752 A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-130 reporter+balance group. Unimod:737 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-130 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01753 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-130 reporter+balance reagent acylated N-terminal MOD:01753 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-130 reporter+balance group. Unimod:737#N-term DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01754 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-130 reporter+balance reagent N6-acylated lysine MOD:01754 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. Unimod:737#K DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg: 357.26 MassMono: 357.257895 Origin: K Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01755 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-130 reporter+balance reagent O4'-acylated tyrosine MOD:01755 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. Unimod:737#Y DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg: 392.23 MassMono: 392.226261 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01756 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-130 reporter+balance reagent N'-acylated histidine MOD:01756 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg: 366.22 MassMono: 366.221844 Origin: H Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01757 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-130 reporter+balance reagent O3-acylated serine MOD:01757 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg: 316.19 MassMono: 316.194961 Origin: S Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01758 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-130 reporter+balance reagent O3-acylated threonine MOD:01758 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-130 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg: 330.21 MassMono: 330.210611 Origin: T Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-130 reagent acylated residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-130 reporter fragment PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01759 TMT6plex-130 reporter fragment MOD:01759 The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-130 reagent acylated residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 4 (13)C 4 H 16 (14)N 1 MassAvg: 130.14 MassMono: 130.141145 Origin: X Source: artifact TermSpec: none 2,6-dimethyl-1-methylidenepiperidinium cysTMT6plex-130 reporter fragment Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-131 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl cysTMT6plex-131 reporter fragment PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01760 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-131 reporter+balance reagent acylated residue MOD:01760 A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-131 reporter+balance group. Unimod:737 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl cysTMT6plex-131 reporter fragment Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-131 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01761 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-131 reporter+balance reagent acylated N-terminal MOD:01761 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-131 reporter+balance group. Unimod:737#N-term DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01762 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-131 reporter+balance reagent N6-acylated lysine MOD:01762 A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. Unimod:737#K DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3 MassAvg: 357.26 MassMono: 357.257895 Origin: K Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01763 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-131 reporter+balance reagent O4'-acylated tyrosine MOD:01763 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. Unimod:737#Y DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4 MassAvg: 392.23 MassMono: 392.226261 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:737 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01764 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-131 reporter+balance reagent N'-acylated histidine MOD:01764 A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3 MassAvg: 366.22 MassMono: 366.221844 Origin: H Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01765 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-131 reporter+balance reagent O3-acylated serine MOD:01765 A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4 MassAvg: 316.19 MassMono: 316.194961 Origin: S Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01766 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. TMT6plex-131 reporter+balance reagent O3-acylated threonine MOD:01766 A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-131 reporter+balance group. PubMed:18688235 DiffAvg: 229.16 DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2 DiffMono: 229.162932 Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4 MassAvg: 330.21 MassMono: 330.210611 Origin: T Source: artifact TermSpec: none 3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl Sixplex Tandem Mass Tag(TM) TMT6plex The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-131 reagent acylated residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,6-dimethyl-1-methylidenepiperidinium PSI-MOD Sixplex Tandem Mass Tag(TM) TMT6plex MOD:01767 TMT6plex-131 reporter fragment MOD:01767 The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-131 reagent acylated residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 4 (13)C 4 H 16 (15)N 1 MassAvg: 131.14 MassMono: 131.138180 Origin: X Source: artifact TermSpec: none 2,6-dimethyl-1-methylidenepiperidinium Sixplex Tandem Mass Tag(TM) TMT6plex A protein modification that effectively replaces a residue hydroxyl group with a palmitoleyloxy group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01768 O-palmitoleylated residue MOD:01768 A protein modification that effectively replaces a residue hydroxyl group with a palmitoleyloxy group. PubMed:18688235 DiffAvg: 236.40 DiffFormula: C 16 H 28 N 0 O 1 DiffMono: 236.214016 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively converts an L-threonine residue to O-palmitoleyl-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S,3R)-2-amino-3-((Z)-9-hexadecenoyloxy)butanoic acid L-threonine cis-9-hexadecenoate ester O-palmitoleylated L-threonine O3-palmitoleyl-threonine mod188 PSI-MOD Palmitoleyl palmitoleyl MOD:01769 O-palmitoleyl-L-threonine MOD:01769 A protein modification that effectively converts an L-threonine residue to O-palmitoleyl-L-threonine. OMSSA:188 PubMed:6642431 PubMed:8413602 RESID:AA0079#var Unimod:431#T DiffAvg: 236.40 DiffFormula: C 16 H 28 N 0 O 1 DiffMono: 236.214016 Formula: C 20 H 35 N 1 O 3 MassAvg: 337.50 MassMono: 337.261694 Origin: T Source: natural TermSpec: none Unimod: Unimod:431 (2S,3R)-2-amino-3-((Z)-9-hexadecenoyloxy)butanoic acid L-threonine cis-9-hexadecenoate ester O-palmitoleylated L-threonine O3-palmitoleyl-threonine mod188 Palmitoleyl palmitoleyl A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine amide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,3R)-2-amino-3-(hexadecanoyloxy)butanamide OPamThrN PSI-MOD MOD:01770 O-palmitoyl-L-threonine amide MOD:01770 A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine amide. PubMed:8413602 RESID:AA0079#var RESID:AA0097#var DiffAvg: 254.44 DiffFormula: C 16 H 32 N 1 O 1 DiffMono: 254.248390 Formula: C 20 H 39 N 2 O 3 MassAvg: 355.54 MassMono: 355.296068 Origin: T Source: natural TermSpec: C-term (2S,3R)-2-amino-3-(hexadecanoyloxy)butanamide OPamThrN The farnesyl cation protein modification reporter fragment produced by fragmentation of some farnesyl modified residues. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylium Farn+ farnesyl cation PSI-MOD MOD:01771 farnesyl reporter fragment MOD:01771 The farnesyl cation protein modification reporter fragment produced by fragmentation of some farnesyl modified residues. PubMed:15609361 PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: C 15 H 25 MassAvg: 205.36 MassMono: 205.195077 Origin: X Source: natural TermSpec: none (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylium Farn+ farnesyl cation The palmityl cation protein modification reporter fragment produced by fragmentation of some palmitoyl modified residues. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Pam+ PSI-MOD palmityl cation MOD:01772 palmityl reporter fragment MOD:01772 The palmityl cation protein modification reporter fragment produced by fragmentation of some palmitoyl modified residues. PubMed:18688235 PubMed:8413602 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: C 16 H 31 O 1 MassAvg: 239.42 MassMono: 239.236942 Origin: X Source: natural TermSpec: none Pam+ palmityl cation Covalent modification of a trimethyllysine residue with secondary loss of a neutral trimethylamine molecular fragment. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: dMe3N6Me3+Lys PSI-MOD MOD:01773 N6,N6,N6-trimethyl-L-lysine with neutral loss of trimethylamine MOD:01773 Covalent modification of a trimethyllysine residue with secondary loss of a neutral trimethylamine molecular fragment. PubMed:17205979 PubMed:18688235 DiffAvg: -59.11 DiffFormula: C -3 H -9 N -1 O 0 DiffMono: -59.074048 FormalCharge: 1+ Formula: C 6 H 10 N 1 O 1 MassAvg: 112.15 MassMono: 112.075690 Origin: MOD:00083 Source: artifact TermSpec: none dMe3N6Me3+Lys A protein modification that effectively converts an L-lysine residue to N6-octanoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-(octanoylamino)hexanoic acid N(zeta)-octanoyllysine N6-(1-oxooctyl)-L-lysine N6-octanoyl-L-lysine epsilon-octanoyllysine PSI-MOD MOD:01774 N6-octanoyl-L-lysine MOD:01774 A protein modification that effectively converts an L-lysine residue to N6-octanoyl-L-lysine. PubMed:12591875 PubMed:2215217 RESID:AA0527 DiffAvg: 126.20 DiffFormula: C 8 H 14 N 0 O 1 DiffMono: 126.104465 Formula: C 14 H 26 N 2 O 2 MassAvg: 254.37 MassMono: 254.199428 Origin: K Source: natural TermSpec: none (2S)-2-amino-6-(octanoylamino)hexanoic acid N(zeta)-octanoyllysine N6-(1-oxooctyl)-L-lysine N6-octanoyl-L-lysine epsilon-octanoyllysine A protein modification that effectively converts an L-glutamine residue to 5-glutamyl serotonin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-([2-(5-hydroxy-1H-indol-3-yl)ethyl]amino)-5-oxopentanoic acid 5-glutamyl serotonin N2-(gamma-glutamyl)-5-hydoxytryptamine N5-[2-(5-hydroxy-3-indolyl)ethyl]glutamine PSI-MOD MOD:01775 5-glutamyl serotonin MOD:01775 A protein modification that effectively converts an L-glutamine residue to 5-glutamyl serotonin. PubMed:11805836 PubMed:14697203 RESID:AA0528 DiffAvg: 159.19 DiffFormula: C 10 H 9 N 1 O 1 DiffMono: 159.068414 Formula: C 15 H 17 N 3 O 3 MassAvg: 287.32 MassMono: 287.126991 Origin: Q Source: natural TermSpec: none (2S)-2-amino-5-([2-(5-hydroxy-1H-indol-3-yl)ethyl]amino)-5-oxopentanoic acid 5-glutamyl serotonin N2-(gamma-glutamyl)-5-hydoxytryptamine N5-[2-(5-hydroxy-3-indolyl)ethyl]glutamine A protein modification that effectively converts an L-cysteine residue to S-methylthiocarbonylaminoethylcysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-([2-([(methylsulfanyl)carbonyl]amino)ethyl]sulfanyl)propanoic acid L-cysteine N-(methylthiocarbonyl)aziridine adduct MTCTK N6-methylthiocarbonyl-4-thialysine S-[2-([(methylthio)carbonyl]amino)ethyl]-L-cysteine PSI-MOD MOD:01776 This modified residue is a chemical analog of N6-acetyl-L-lysine produced from L-cysteine by methylthiocarbonylaziridine (MTCA, S-methyl aziridine-1-carbothioate). S-methylthiocarbonylaminoethylcysteine (Cys) MOD:01776 A protein modification that effectively converts an L-cysteine residue to S-methylthiocarbonylaminoethylcysteine. PubMed:18688235 PubMed:20608637 DiffAvg: 117.17 DiffFormula: C 4 H 7 N 1 O 1 S 1 DiffMono: 117.024835 Formula: C 7 H 12 N 2 O 2 S 2 MassAvg: 220.31 MassMono: 220.034020 Origin: C Source: artifact TermSpec: none (2R)-2-amino-3-([2-([(methylsulfanyl)carbonyl]amino)ethyl]sulfanyl)propanoic acid L-cysteine N-(methylthiocarbonyl)aziridine adduct MTCTK N6-methylthiocarbonyl-4-thialysine S-[2-([(methylthio)carbonyl]amino)ethyl]-L-cysteine A protein modification that effectively converts a C-terminal glycine residue to S-(glycyl)-L-cysteine by forming a thioester bond with a free L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid 1-(cystein-S-yl)-glycinate MOD_RES CysO-cysteine adduct S-(2-amino-1-oxoethyl)cysteine S-(glycyl)-L-cysteine glycine cysteine thioester PSI-MOD MOD:01777 This is not the cross-linking of two peptides, but the modification of a C-terminal glycine by formation of an thioester bond with a free cysteine. For the cross-linking of two peptide see MOD:00211 [JSG]. S-(glycyl)-L-cysteine (Gly) MOD:01777 A protein modification that effectively converts a C-terminal glycine residue to S-(glycyl)-L-cysteine by forming a thioester bond with a free L-cysteine. ChEBI:22050 PubMed:17726030 PubMed:18359941 PubMed:18771296 PubMed:18799456 PubMed:18842002 PubMed:3306404 RESID:AA0206 DiffAvg: 103.14 DiffFormula: C 3 H 5 N 1 O 1 S 1 DiffMono: 103.009185 Formula: C 5 H 9 N 2 O 3 S 1 MassAvg: 177.20 MassMono: 177.033388 Origin: G Source: natural TermSpec: C-term (2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid 1-(cystein-S-yl)-glycinate MOD_RES CysO-cysteine adduct S-(2-amino-1-oxoethyl)cysteine S-(glycyl)-L-cysteine glycine cysteine thioester A protein modification that effectively converts a C-terminal glycine residue to N-(glycyl)-L-cysteine by forming a peptide bond with a free L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0433 (2R)-2-[(aminoacetyl)amino]-3-sulfanylpropanoic acid MOD_RES CysO-cysteine adduct N-(2-amino-1-oxoethyl)cysteine N-(glycyl)-L-cysteine PSI-MOD MOD:01778 N-(glycyl)-L-cysteine MOD:01778 A protein modification that effectively converts a C-terminal glycine residue to N-(glycyl)-L-cysteine by forming a peptide bond with a free L-cysteine. PubMed:18771296 PubMed:18799456 PubMed:18842002 RESID:AA0529 DiffAvg: 103.14 DiffFormula: C 3 H 5 N 1 O 1 S 1 DiffMono: 103.009185 Formula: C 5 H 9 N 2 O 3 S 1 MassAvg: 177.20 MassMono: 177.033388 Origin: G Source: hypothetical TermSpec: C-term (2R)-2-[(aminoacetyl)amino]-3-sulfanylpropanoic acid MOD_RES CysO-cysteine adduct N-(2-amino-1-oxoethyl)cysteine N-(glycyl)-L-cysteine A protein modification that effectively converts an L-lysine residue to N6-(L-lysyl)-L-lysine by formation of an isopeptide bond between the carboxyl group of a free lysine and the N6-amino group of the peptidyl L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid N6-(L-lysyl)-L-lysine N6-(alpha-lysyl)-lysine PSI-MOD MOD:01779 This is not the cross-linking of two peptides, but the modification of a peptidyl lysine by formation of an isopeptide bond with a free lysine [JSG]. N6-(L-lysyl)-L-lysine MOD:01779 A protein modification that effectively converts an L-lysine residue to N6-(L-lysyl)-L-lysine by formation of an isopeptide bond between the carboxyl group of a free lysine and the N6-amino group of the peptidyl L-lysine. PubMed:18201202 PubMed:20729861 RESID:AA0530 DiffAvg: 128.18 DiffFormula: C 6 H 12 N 2 O 1 DiffMono: 128.094963 Formula: C 12 H 24 N 4 O 2 MassAvg: 256.35 MassMono: 256.189926 Origin: K Source: natural TermSpec: none (2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid N6-(L-lysyl)-L-lysine N6-(alpha-lysyl)-lysine A protein modification that effectively converts an L-lysine residue to N6-(beta-lysyl)-L-5-hydroxylysine by formation of an isopeptide bond between the carboxyl group of a free beta-lysine and the N6-amino group of a peptidyl L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0474 (2S)-2-amino-6-([(3R)-3,6-diaminohexanoyl]amino)-5-hydroxyhexanoic acid 5-hydroxy-N6-(beta-lysyl)-L-lysine 5-hydroxy-N6-[(3R)-beta-lysyl]lysine EF-P lysine derivative MOD_RES N6-(3,6-diaminohexanoyl)-5-hydroxylysine N6-[(3R)-3,6-diaminohexanoyl]-L-5-hydroxylysine lysyl spermidine derivative [misidentification] PSI-MOD MOD:01780 N6-(beta-lysyl)-L-5-hydroxylysine MOD:01780 A protein modification that effectively converts an L-lysine residue to N6-(beta-lysyl)-L-5-hydroxylysine by formation of an isopeptide bond between the carboxyl group of a free beta-lysine and the N6-amino group of a peptidyl L-lysine. PubMed:18201202 PubMed:20729861 RESID:AA0531 DiffAvg: 144.17 DiffFormula: C 6 H 12 N 2 O 2 DiffMono: 144.089878 Formula: C 12 H 24 N 4 O 3 MassAvg: 272.35 MassMono: 272.184841 Origin: K Source: hypothetical TermSpec: none (2S)-2-amino-6-([(3R)-3,6-diaminohexanoyl]amino)-5-hydroxyhexanoic acid 5-hydroxy-N6-(beta-lysyl)-L-lysine 5-hydroxy-N6-[(3R)-beta-lysyl]lysine EF-P lysine derivative MOD_RES N6-(3,6-diaminohexanoyl)-5-hydroxylysine N6-[(3R)-3,6-diaminohexanoyl]-L-5-hydroxylysine lysyl spermidine derivative [misidentification] A protein modification that effectively converts an L-lysine residue to N6-butanoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0637 (2S)-2-amino-6-(butanoylamino)hexanoic acid (2S)-2-azanyl-6-(butanoylamino)hexanoic acid 2-amino-6-butyrylaminocaproic acid MOD_RES N6-butyryllysine N(zeta)-butanoyllysine N6-(1-oxobutyl)-L-lysine N6-butanoyl-L-lysine N6-butyryllysine epsilon-butanoyl-L-lysine epsilon-butyryl-L-lysine PSI-MOD MOD:01781 The binding of histone peptides with butanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG]. N6-butanoyl-L-lysine MOD:01781 A protein modification that effectively converts an L-lysine residue to N6-butanoyl-L-lysine. PubMed:17267393 PubMed:20715035 RESID:AA0532 Unimod:1289 DiffAvg: 70.09 DiffFormula: C 4 H 6 N 0 O 1 DiffMono: 70.041865 Formula: C 10 H 18 N 2 O 2 MassAvg: 198.27 MassMono: 198.136828 Origin: K Source: hypothetical TermSpec: none Unimod: Unimod:1289 (2S)-2-amino-6-(butanoylamino)hexanoic acid (2S)-2-azanyl-6-(butanoylamino)hexanoic acid 2-amino-6-butyrylaminocaproic acid MOD_RES N6-butyryllysine N(zeta)-butanoyllysine N6-(1-oxobutyl)-L-lysine N6-butanoyl-L-lysine N6-butyryllysine epsilon-butanoyl-L-lysine epsilon-butyryl-L-lysine A protein modification that effectively converts an L-serine residue to N-methyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0432 (2S)-3-hydroxy-2-(methylamino)propanoic acid MOD_RES N-methylserine N-methyl-L-serine N-methylserine PSI-MOD MOD:01782 N-methyl-L-serine MOD:01782 A protein modification that effectively converts an L-serine residue to N-methyl-L-serine. PubMed:20668449 RESID:AA0533 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 4 H 7 N 1 O 2 MassAvg: 101.10 MassMono: 101.047678 Origin: S Source: natural TermSpec: none (2S)-3-hydroxy-2-(methylamino)propanoic acid MOD_RES N-methylserine N-methyl-L-serine N-methylserine A protein modification that effectively converts an L-serine residue to N,N-dimethyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0431 (2S)-2-(dimethylamino)propanoic acid MOD_RES N,N-dimethylserine N,N-dimethyl-L-serine N,N-dimethylserine PSI-MOD MOD:01783 N,N-dimethyl-L-serine MOD:01783 A protein modification that effectively converts an L-serine residue to N,N-dimethyl-L-serine. PubMed:20668449 RESID:AA0534 DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 5 H 10 N 1 O 2 MassAvg: 116.14 MassMono: 116.071154 Origin: S Source: natural TermSpec: N-term (2S)-2-(dimethylamino)propanoic acid MOD_RES N,N-dimethylserine N,N-dimethyl-L-serine N,N-dimethylserine A protein modification that effectively converts an L-serine residue to N,N,N-trimethyl-L-serine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0430 (1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanaminium (1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanazanium (2S)-2-trimethylammonio-3-hydroxypropanoic acid MOD_RES N,N,N-trimethylserine N,N,N-trimethyl-L-serine N,N,N-trimethylserine cation N,N,N-trimethylserinium PSI-MOD MOD:01784 N,N,N-trimethyl-L-serine MOD:01784 A protein modification that effectively converts an L-serine residue to N,N,N-trimethyl-L-serine. PubMed:20668449 PubMed:3979397 RESID:AA0535 DiffAvg: 43.09 DiffFormula: C 3 H 7 N 0 O 0 DiffMono: 43.054227 FormalCharge: 1+ Formula: C 6 H 13 N 1 O 2 MassAvg: 131.17 MassMono: 131.094080 Origin: S Source: natural TermSpec: N-term (1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanaminium (1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanazanium (2S)-2-trimethylammonio-3-hydroxypropanoic acid MOD_RES N,N,N-trimethylserine N,N,N-trimethyl-L-serine N,N,N-trimethylserine cation N,N,N-trimethylserinium A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid 5-(threon-O3-yl)glutamate O(beta)-(gamma-glutamyl)threonine O-(L-isoglutamyl)-L-threonine O3-(isoglutamyl)threonine PSI-MOD MOD:01785 This is not an ester cross-link of peptides [JSG]. O-(L-isoglutamyl)-L-threonine (active site intermediate) MOD:01785 A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia. PubMed:8706862 RESID:AA0536#THR DiffAvg: 129.12 DiffFormula: C 5 H 7 N 1 O 3 DiffMono: 129.042593 Formula: C 9 H 14 N 2 O 5 MassAvg: 230.22 MassMono: 230.090272 Origin: T Source: hypothetical TermSpec: none (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid 5-(threon-O3-yl)glutamate O(beta)-(gamma-glutamyl)threonine O-(L-isoglutamyl)-L-threonine O3-(isoglutamyl)threonine A protein modification that effectively converts an L-tyrosine residue to 3'-nitro-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0434 (2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid 3'-nitro-L-tyrosine 3-nitro-L-tyrosine 3-nitrotyrosine MOD_RES 3'-Nitrotyrosine m-nitrotyrosine meta-nitrotyrosine PSI-MOD MOD:01786 3'-nitro-L-tyrosine MOD:01786 A protein modification that effectively converts an L-tyrosine residue to 3'-nitro-L-tyrosine. ChEBI:44454 PubMed:16944230 PubMed:5339594 RESID:AA0537 DiffAvg: 45.00 DiffFormula: C 0 H -1 N 1 O 2 DiffMono: 44.985078 Formula: C 9 H 8 N 2 O 4 MassAvg: 208.17 MassMono: 208.048407 Origin: Y Source: natural TermSpec: none (2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid 3'-nitro-L-tyrosine 3-nitro-L-tyrosine 3-nitrotyrosine MOD_RES 3'-Nitrotyrosine m-nitrotyrosine meta-nitrotyrosine A protein modification that effectively cross-links two L-tyrosine residues through their 5' positions by amine nitrogen to form 5'-(L-tyros-5'-yl)amino-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0320 (2S,2'S)-3,3'-[iminobis(4-hydroxybenzene-3,1-diyl)]bis(2-aminopropanoic acid) 5'-(L-tyros-5'-yl)amino-L-tyrosine 5'-[(tyros-5'-yl)amino]tyrosine 5'-tyrosyl-5'-aminotyrosine CROSSLNK 5'-tyrosyl-5'-aminotyrosine (Tyr-Tyr) (interchain) bis(LTQ) linkage PSI-MOD MOD:01787 Cross-link 2. 5'-(L-tyros-5'-yl)amino-L-tyrosine MOD:01787 A protein modification that effectively cross-links two L-tyrosine residues through their 5' positions by amine nitrogen to form 5'-(L-tyros-5'-yl)amino-L-tyrosine. PubMed:18781570 RESID:AA0459 DiffAvg: 13.00 DiffFormula: C 0 H -1 N 1 O 0 DiffMono: 12.995249 Formula: C 18 H 17 N 3 O 4 MassAvg: 339.35 MassMono: 339.121906 Origin: Y, Y Source: hypothetical TermSpec: none (2S,2'S)-3,3'-[iminobis(4-hydroxybenzene-3,1-diyl)]bis(2-aminopropanoic acid) 5'-(L-tyros-5'-yl)amino-L-tyrosine 5'-[(tyros-5'-yl)amino]tyrosine 5'-tyrosyl-5'-aminotyrosine CROSSLNK 5'-tyrosyl-5'-aminotyrosine (Tyr-Tyr) (interchain) bis(LTQ) linkage A protein modification that effectively converts an N-terminal L-histidine residue to histidine immonium ion. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-(1H-imidazolyl)ethaniminium PSI-MOD MOD:01788 This fragment corresponds to the first ion in an a+ series. histidine immonium ion MOD:01788 A protein modification that effectively converts an N-terminal L-histidine residue to histidine immonium ion. PubMed:17074506 PubMed:18688235 DiffAvg: -27.00 DiffFormula: C -1 H 1 N 0 O -1 DiffMono: -26.987638 FormalCharge: 1+ Formula: C 5 H 8 N 3 O 0 MassAvg: 110.14 MassMono: 110.071274 Origin: H Source: artifact TermSpec: none 2-(1H-imidazolyl)ethaniminium A protein modification that effectively converts an N-terminal L-phenylalanine residue to phenylalanine immonium ion. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-phenylethaniminium PSI-MOD MOD:01789 This fragment corresponds to the first ion in an a+ series. phenylalanine immonium ion MOD:01789 A protein modification that effectively converts an N-terminal L-phenylalanine residue to phenylalanine immonium ion. PubMed:17074506 PubMed:18688235 DiffAvg: -27.00 DiffFormula: C -1 H 1 N 0 O -1 DiffMono: -26.987638 FormalCharge: 1+ Formula: C 8 H 10 N 1 O 0 MassAvg: 120.17 MassMono: 120.080776 Origin: F Source: artifact TermSpec: none 2-phenylethaniminium A protein modification that effectively converts an an N-terminal L-tyrosine residue to tyrosine immonium ion. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-(4-hydroxyphenyl)ethaniminium PSI-MOD MOD:01790 This fragment corresponds to the first ion in an a+ series. tyrosine immonium ion MOD:01790 A protein modification that effectively converts an an N-terminal L-tyrosine residue to tyrosine immonium ion. PubMed:17074506 PubMed:18688235 DiffAvg: -27.00 DiffFormula: C -1 H 1 N 0 O -1 DiffMono: -26.987638 FormalCharge: 1+ Formula: C 8 H 10 N 1 O 1 MassAvg: 136.17 MassMono: 136.075690 Origin: Y Source: artifact TermSpec: none 2-(4-hydroxyphenyl)ethaniminium A protein modification that effectively converts an N-terminal phosphohistidine residue to phosphohistidine immonium ion. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-(1H-imidazolyl)ethaniminium PSI-MOD MOD:01791 This fragment corresponds to the first ion in an a+ series. phosphohistidine immonium ion MOD:01791 A protein modification that effectively converts an N-terminal phosphohistidine residue to phosphohistidine immonium ion. PubMed:17690871 PubMed:18688235 PubMed:20847263 DiffAvg: -27.00 DiffFormula: C -1 H 1 N 0 O -1 DiffMono: -26.987638 FormalCharge: 1+ Formula: C 5 H 9 N 3 O 3 P 1 MassAvg: 190.12 MassMono: 190.037604 Origin: MOD:00890 Source: artifact TermSpec: none 2-(1H-imidazolyl)ethaniminium A protein modification that effectively converts an N-terminal O4'-phospho-L-tyrosine residue to tyrosine immonium ion. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-(4-phosphonoxyphenyl)ethaniminium PSI-MOD MOD:01792 This fragment corresponds to the first ion in an a+ series. phosphotyrosine immonium ion MOD:01792 A protein modification that effectively converts an N-terminal O4'-phospho-L-tyrosine residue to tyrosine immonium ion. PubMed:17690871 PubMed:18688235 DiffAvg: -27.00 DiffFormula: C -1 H 1 N 0 O -1 DiffMono: -26.987638 FormalCharge: 1+ Formula: C 8 H 11 N 1 O 4 P 1 MassAvg: 216.15 MassMono: 216.042021 Origin: MOD:00048 Source: artifact TermSpec: none 2-(4-phosphonoxyphenyl)ethaniminium A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfoxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: CamCO S-carbamoylmethyl-L-cysteine sulfoxide PSI-MOD MOD:01793 S-carboxamidomethyl-L-cysteine sulfoxide MOD:01793 A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfoxide. PubMed:11212008 PubMed:17689096 PubMed:18306178 PubMed:18688235 DiffAvg: 73.05 DiffFormula: C 2 H 3 N 1 O 2 DiffMono: 73.016378 Formula: C 5 H 8 N 2 O 3 S 1 MassAvg: 176.19 MassMono: 176.025563 Origin: C Source: artifact TermSpec: none CamCO S-carbamoylmethyl-L-cysteine sulfoxide A protein modification that effectively replaces the methyl group of a residue containing common isotopes with a 1x(13)C,3x(2)H labeled monomethylated residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD Methyl:2H(3)13C(1) MOD:01794 1x(13)C,3x(2)H labeled monomethylated residue MOD:01794 A protein modification that effectively replaces the methyl group of a residue containing common isotopes with a 1x(13)C,3x(2)H labeled monomethylated residue. PubMed:18688235 DiffAvg: 18.04 DiffFormula: (13)C 1 (1)H -1 (2)H 3 DiffMono: 18.037835 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Methyl:2H(3)13C(1) A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD Methyl:2H(3)13C(1) MOD:01795 1x(13)C,3x(2)H C(6)-labeled L-methionine MOD:01795 A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine. PubMed:15782174 PubMed:18688235 DiffAvg: 4.02 DiffFormula: (12)C -1 (13)C 1 (1)H -3 (2)H 3 DiffMono: 4.022185 Formula: (12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 1 S 1 MassAvg: 135.06 MassMono: 135.062670 Origin: M Source: artifact TermSpec: none Methyl:2H(3)13C(1) A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01796 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide MOD:01796 A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide. PubMed:15782174 PubMed:18688235 DiffAvg: 20.02 DiffFormula: (12)C -1 (13)C 1 (1)H -3 (2)H 3 O 1 DiffMono: 20.017100 Formula: (12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 2 S 1 MassAvg: 151.06 MassMono: 151.057585 Origin: M Source: artifact TermSpec: none A protein modification that effectively converts an N-terminal 1'-phosphohistidine residue to 1'-phosphohistidine immonium ion. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-((1-phosphono-1H-imidazol-4-yl)ethaniminium Ntau-phosphorylated L-histidine PSI-MOD MOD:01797 This fragment corresponds to the first ion in an a+ series. 1'-phosphohistidine immonium ion MOD:01797 A protein modification that effectively converts an N-terminal 1'-phosphohistidine residue to 1'-phosphohistidine immonium ion. PubMed:17690871 PubMed:18688235 PubMed:20847263 DiffAvg: -27.00 DiffFormula: C -1 H 1 N 0 O -1 DiffMono: -26.987638 FormalCharge: 1+ Formula: C 5 H 9 N 3 O 3 P 1 MassAvg: 190.12 MassMono: 190.037604 Origin: MOD:00044 Source: artifact TermSpec: none 2-((1-phosphono-1H-imidazol-4-yl)ethaniminium Ntau-phosphorylated L-histidine A protein modification that effectively converts an N-terminal 3'-phosphohistidine residue to 3'-phosphohistidine immonium ion. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-(1-phosphono-1H-imidazol-5-yl)ethaniminium Npi-phosphorylated L-histidine PSI-MOD MOD:01798 This fragment corresponds to the first ion in an a+ series. 3'-phosphohistidine immonium ion MOD:01798 A protein modification that effectively converts an N-terminal 3'-phosphohistidine residue to 3'-phosphohistidine immonium ion. PubMed:18688235 DiffAvg: -27.00 DiffFormula: C -1 H 1 N 0 O -1 DiffMono: -26.987638 FormalCharge: 1+ Formula: C 5 H 9 N 3 O 3 P 1 MassAvg: 190.12 MassMono: 190.037604 Origin: MOD:00045 Source: artifact TermSpec: none 2-(1-phosphono-1H-imidazol-5-yl)ethaniminium Npi-phosphorylated L-histidine A protein modification that effectively converts an L-alanine residue to a methylated serine, such as N-methylserine, N,N-dimethylserine, or N,N,N-trimethylserine. Origin: MeSer PSI-MOD MOD:01799 methylated serine MOD:01799 A protein modification that effectively converts an L-alanine residue to a methylated serine, such as N-methylserine, N,N-dimethylserine, or N,N,N-trimethylserine. PubMed:18688235 Origin: S MeSer A protein modification that effectively replaces an L-serine alpha amino hydrogen with a methyl group. Origin: Source: TermSpec: PSI-MOD MOD:01800 N-methylated serine MOD:01800 A protein modification that effectively replaces an L-serine alpha amino hydrogen with a methyl group. PubMed:18688235 Origin: S Source: natural TermSpec: N-term A protein modification that effectively converts an L-serine residue to an L-serinium (protonated L-serine). DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01801 protonated L-serine (L-serinium) residue MOD:01801 A protein modification that effectively converts an L-serine residue to an L-serinium (protonated L-serine). PubMed:18688235 DiffAvg: 1.01 DiffFormula: C 0 H 1 N 0 O 0 DiffMono: 1.007276 FormalCharge: 1+ Formula: C 3 H 7 N 1 O 2 MassAvg: 89.09 MassMono: 89.047130 Origin: S Source: natural TermSpec: N-term A protein modification that effectively converts an L-serinium (protonated L-serine) residue to an N,N,N-trimethyl-L-serine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N2Me3Ala PSI-MOD MOD:01802 For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ser process (MOD:00071) accounts for both protonation and trimethylation. N,N,N-trimethyl-L-serine (from L-serinium) MOD:01802 A protein modification that effectively converts an L-serinium (protonated L-serine) residue to an N,N,N-trimethyl-L-serine. PubMed:18688235 DiffAvg: 42.08 DiffFormula: C 3 H 6 N 0 O 0 DiffMono: 42.046402 FormalCharge: 1+ Formula: C 6 H 13 N 1 O 2 MassAvg: 131.17 MassMono: 131.094080 Origin: MOD:01801 Source: natural TermSpec: N-term N2Me3Ala A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine or L-threonine methyl ester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: OMeThr PSI-MOD MOD:01803 O-methylated threonine MOD:01803 A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine or L-threonine methyl ester. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: T Source: natural TermSpec: none OMeThr A protein modification that effectively results from forming an adduct with a glycosylphosphate through a phosphodiester bond. PSI-MOD MOD:01804 glycosylphosphorylated residue MOD:01804 A protein modification that effectively results from forming an adduct with a glycosylphosphate through a phosphodiester bond. PubMed:18688235 A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)-glycine and the release of water. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0490 (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid 2-amino-N4-(carboxymethyl)-butanediamic acid CROSSLNK Isoaspartyl glycine isopeptide (Asp-Gly) CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asp) N-(L-isoaspartyl)-glycine N-beta-aspartylglycine N4-(carboxymethyl)-asparagine isoaspartyl glycine PSI-MOD MOD:01805 Cross-link 2. N-(L-isoaspartyl)-glycine (Asp) MOD:01805 A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)-glycine and the release of water. ChEBI:21479 PubMed:1826288 PubMed:18671394 RESID:AA0126 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 6 H 7 N 2 O 3 MassAvg: 155.13 MassMono: 155.045667 Origin: D, G Source: natural TermSpec: N-term (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid 2-amino-N4-(carboxymethyl)-butanediamic acid CROSSLNK Isoaspartyl glycine isopeptide (Asp-Gly) CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asp) N-(L-isoaspartyl)-glycine N-beta-aspartylglycine N4-(carboxymethyl)-asparagine isoaspartyl glycine A protein modification that effectively converts an L-leucine residue to N,N-dimethyl-L-leucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0435 (2S)-2-(dimethylamino)-4-methylpentanoic acid 2-(dimethylamino)-4-methylvaleric acid 2-(dimethylazanyl)-4-methylpentanoic acid MOD_RES N,N-dimethylleucine N,N-dimethyl-L-leucine N,N-dimethylleucine PSI-MOD MOD:01806 N,N-dimethyl-L-leucine MOD:01806 A protein modification that effectively converts an L-leucine residue to N,N-dimethyl-L-leucine. PubMed:19522542 RESID:AA0538 DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 8 H 16 N 1 O 1 MassAvg: 142.22 MassMono: 142.123189 Origin: L Source: hypothetical TermSpec: N-term (2S)-2-(dimethylamino)-4-methylpentanoic acid 2-(dimethylamino)-4-methylvaleric acid 2-(dimethylazanyl)-4-methylpentanoic acid MOD_RES N,N-dimethylleucine N,N-dimethyl-L-leucine N,N-dimethylleucine A protein modification that effectively converts an L-glutamic acid residue to N-formyl-L-glutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-(formylamino)pentanedioic acid 2-(formylazanyl)pentanedioic acid 2-formamidopentanedioic acid 2-formylaminopentanedioic acid N-formyl-L-glutamic acid PSI-MOD MOD:01807 N-formyl-L-glutamic acid MOD:01807 A protein modification that effectively converts an L-glutamic acid residue to N-formyl-L-glutamic acid. PubMed:18001127 RESID:AA0539 DiffAvg: 28.01 DiffFormula: C 1 H 0 N 0 O 1 DiffMono: 27.994915 Formula: C 6 H 8 N 1 O 4 MassAvg: 158.13 MassMono: 158.045333 Origin: E Source: artifact TermSpec: N-term (2S)-2-(formylamino)pentanedioic acid 2-(formylazanyl)pentanedioic acid 2-formamidopentanedioic acid 2-formylaminopentanedioic acid N-formyl-L-glutamic acid A protein modification that effectively replaces an L-leucine alpha amino hydrogen with a methyl group. Origin: MeLeu PSI-MOD MOD:01808 N-methylated leucine MOD:01808 A protein modification that effectively replaces an L-leucine alpha amino hydrogen with a methyl group. PubMed:18688235 Origin: L MeLeu A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C,1x(15)N labeled residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(5) 15N(1) Silac label Label:13C(5)15N(1) MOD:01809 5x(13)C,1x(15)N labeled residue MOD:01809 A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C,1x(15)N labeled residue. PubMed:12771378 Unimod:268 DiffAvg: 6.01 DiffFormula: (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono: 6.013809 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:268 13C(5) 15N(1) Silac label Label:13C(5)15N(1) A protein modification that effectively converts an L-proline residue to 5x(13)C,1x(15)N labeled L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(5) 15N(1) Silac label Label:13C(5)15N(1) MOD:01810 5x(13)C,1x(15)N labeled L-proline MOD:01810 A protein modification that effectively converts an L-proline residue to 5x(13)C,1x(15)N labeled L-proline. PubMed:12771378 Unimod:268#P DiffAvg: 6.01 DiffFormula: (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono: 6.013809 Formula: (13)C 5 H 7 (15)N 1 O 1 MassAvg: 103.07 MassMono: 103.066573 Origin: P Source: artifact TermSpec: none Unimod: Unimod:268 13C(5) 15N(1) Silac label Label:13C(5)15N(1) A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(5) 15N(1) Silac label Label:13C(5)15N(1) MOD:01811 5x(13)C,1x(15)N labeled L-methionine MOD:01811 A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine. PubMed:12771378 Unimod:268#M DiffAvg: 6.01 DiffFormula: (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono: 6.013809 Formula: (13)C 5 H 9 (15)N 1 O 1 S 1 MassAvg: 137.05 MassMono: 137.054294 Origin: M Source: artifact TermSpec: none Unimod: Unimod:268 13C(5) 15N(1) Silac label Label:13C(5)15N(1) A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine sulfoxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(5) 15N(1) Silac label Label:13C(5)15N(1) MOD:01812 5x(13)C,1x(15)N labeled L-methionine sulfoxide MOD:01812 A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine sulfoxide. PubMed:12771378 Unimod:268#M DiffAvg: 6.01 DiffFormula: (12)C -5 (13)C 5 (14)N -1 (15)N 1 DiffMono: 6.013809 Formula: (13)C 5 H 9 (15)N 1 O 2 S 1 MassAvg: 153.05 MassMono: 153.049209 Origin: M Source: artifact TermSpec: none Unimod: Unimod:268 13C(5) 15N(1) Silac label Label:13C(5)15N(1) A protein modification that effectively substitutes a morpholine-2-acetyl group for a hydrogen atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: Unimod: N-succinimidylmorpholine-2-acetate derivative PSI-MOD N-Succinimidyl-2-morpholine acetate SMA MOD:01813 The Unimod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG]. morpholine-2-acetylated residue MOD:01813 A protein modification that effectively substitutes a morpholine-2-acetyl group for a hydrogen atom. PubMed:10446193 Unimod:29 DiffAvg: 127.14 DiffFormula: C 6 H 9 N 1 O 2 DiffMono: 127.063329 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact Unimod: Unimod:29 N-succinimidylmorpholine-2-acetate derivative N-Succinimidyl-2-morpholine acetate SMA A protein modification that effectively cross-links a cysteine and two serine residues to form L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0454 6-[(1R)-1-amino-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid 6-[1-azanyl-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid PSI-MOD CROSSLNK 3-hydroxypyridine-2,5-dicarboxylic acid (Ser-Cys) MOD:01814 Cross-link 3. L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid MOD:01814 A protein modification that effectively cross-links a cysteine and two serine residues to form L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid. PubMed:18406324 PubMed:19678698 PubMed:893891 RESID:AA0540 DiffAvg: -54.07 DiffFormula: C 0 H -8 N -1 O -2 S 0 DiffMono: -54.055504 Formula: C 9 H 7 N 2 O 3 S 1 MassAvg: 223.23 MassMono: 223.017738 Origin: C, S, S Source: natural TermSpec: none 6-[(1R)-1-amino-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid 6-[1-azanyl-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid CROSSLNK 3-hydroxypyridine-2,5-dicarboxylic acid (Ser-Cys) A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamic acid residue to form L-glutamate thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0456 2-[(1S)-1-amino-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid 2-[-1-azanyl-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Glu-Cys) L-glutamate thiazole-4-carboxylic acid PSI-MOD MOD:01815 Cross-link 2. L-glutamate thiazole-4-carboxylic acid MOD:01815 A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamic acid residue to form L-glutamate thiazole-4-carboxylic acid. PubMed:18406324 PubMed:19678698 PubMed:893891 RESID:AA0541 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 8 H 8 N 2 O 3 S 1 MassAvg: 212.22 MassMono: 212.025563 Origin: C, E Source: natural TermSpec: none 2-[(1S)-1-amino-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid 2-[-1-azanyl-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Glu-Cys) L-glutamate thiazole-4-carboxylic acid A protein modification that effectively converts an L-tryptophan residue to a 2'-hydroxy-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-(2-hydroxy-1H-indol-3-yl)propanoic acid 2'-hydroxy-L-tryptophan 2-azanyl-3-(2-hydroxy-1H-indol-3-yl)propanoic acid 2-hydroxy-L-tryptophan 2-hydroxy-tryptophan PSI-MOD MOD:01816 2'-hydroxy-L-tryptophan MOD:01816 A protein modification that effectively converts an L-tryptophan residue to a 2'-hydroxy-L-tryptophan. PubMed:11714714 RESID:AA0542 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 11 H 10 N 2 O 2 MassAvg: 202.21 MassMono: 202.074228 Origin: W Source: artifact TermSpec: none (2S)-2-amino-3-(2-hydroxy-1H-indol-3-yl)propanoic acid 2'-hydroxy-L-tryptophan 2-azanyl-3-(2-hydroxy-1H-indol-3-yl)propanoic acid 2-hydroxy-L-tryptophan 2-hydroxy-tryptophan A protein modification that effectively converts an L-tryptophan residue to a 2'-oxo-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid 2'-oxo-L-tryptophan 2-azanyl-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid 2-oxo-L-tryptophan 2-oxotryptophan PSI-MOD MOD:01817 2'-oxo-L-tryptophan MOD:01817 A protein modification that effectively converts an L-tryptophan residue to a 2'-oxo-L-tryptophan. PubMed:9461080 RESID:AA0543 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 11 H 10 N 2 O 2 MassAvg: 202.21 MassMono: 202.074228 Origin: W Source: artifact TermSpec: none (2S)-2-amino-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid 2'-oxo-L-tryptophan 2-azanyl-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid 2-oxo-L-tryptophan 2-oxotryptophan A protein modification that effectively cross-links two tryptophan residues to form 1'-(L-tryptophan-3'-yl)-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0544 (2S,2'S)-3,3'-(3'H-1,3'-biindole-3,3'-diyl)bis(2-aminopropanoic acid) 1-(L-tryptophan-3-yl)-L-tryptophan 2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid 3-[(2S)-2-amino-2-carboxyethyl]-3-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-1H-indole 3-[2-azanyl-2-carboxyethyl]-3-(3-[2-azanyl-2-carboxyethyl]-1H-indol-2-yl)-1H-indole ditryptophan PSI-MOD MOD:01818 Cross-link 2. 1'-(L-tryptophan-3'-yl)-L-tryptophan MOD:01818 A protein modification that effectively cross-links two tryptophan residues to form 1'-(L-tryptophan-3'-yl)-L-tryptophan. PubMed:20600836 RESID:AA0544 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 22 H 18 N 4 O 2 MassAvg: 370.41 MassMono: 370.142976 Origin: W, W Source: natural TermSpec: none (2S,2'S)-3,3'-(3'H-1,3'-biindole-3,3'-diyl)bis(2-aminopropanoic acid) 1-(L-tryptophan-3-yl)-L-tryptophan 2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid 3-[(2S)-2-amino-2-carboxyethyl]-3-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-1H-indole 3-[2-azanyl-2-carboxyethyl]-3-(3-[2-azanyl-2-carboxyethyl]-1H-indol-2-yl)-1H-indole ditryptophan A protein modification that effectively converts an L-lysine residue to N6-succinyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0438 (2S)-2-amino-6-[(3-carboxypropanoyl)amino]hexanoic acid 2-azanyl-6-[(3-carboxypropanoyl)azanyl]hexanoic acid 4-[[(5S)-5-amino-6-hydroxy-6-oxohexyl]amino]-4-oxobutanoate MOD_RES N6-succinyllysine N(epsilon)-(succinyl)lysine N6-succinyl-L-lysine succinyllysine PSI-MOD MOD:01819 N6-succinyl-L-lysine MOD:01819 A protein modification that effectively converts an L-lysine residue to N6-succinyl-L-lysine. PubMed:16582421 PubMed:21151122 RESID:AA0545 DiffAvg: 100.07 DiffFormula: C 4 H 4 N 0 O 3 DiffMono: 100.016044 Formula: C 10 H 16 N 2 O 4 MassAvg: 228.25 MassMono: 228.111007 Origin: K Source: natural TermSpec: none (2S)-2-amino-6-[(3-carboxypropanoyl)amino]hexanoic acid 2-azanyl-6-[(3-carboxypropanoyl)azanyl]hexanoic acid 4-[[(5S)-5-amino-6-hydroxy-6-oxohexyl]amino]-4-oxobutanoate MOD_RES N6-succinyllysine N(epsilon)-(succinyl)lysine N6-succinyl-L-lysine succinyllysine A protein modification that effectively replaces a cysteine sulhydryl hydrogen with an isotope tagged sulfhydryl reagent group. Origin: Source: TermSpec: PSI-MOD MOD:01820 isotope tagged sufhydryl reagent modified cysteine MOD:01820 A protein modification that effectively replaces a cysteine sulhydryl hydrogen with an isotope tagged sulfhydryl reagent group. PubMed:18688235 Origin: C Source: artifact TermSpec: none A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) MOD:01821 The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. cysTMT6plex reporter+balance reagent cysteine disulfide MOD:01821 A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex reporter+balance group. URL:http://www.piercenet.com/files/2162220.pdf Unimod:985 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: C Source: artifact TermSpec: none Unimod: Unimod:985 S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-zero reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD Native cysteine-reactive Tandem Mass Tag(TM) cysTMT MOD:01822 The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. cysTMT6plex-zero reporter+balance reagent cysteine disulfide MOD:01822 A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-zero reporter+balance group. URL:http://www.piercenet.com/files/2162220.pdf Unimod:984 DiffAvg: 299.17 DiffFormula: (12)C 14 H 25 (14)N 3 O 2 S 1 DiffMono: 299.166748 Formula: (12)C 17 H 32 (14)N 4 O 4 S 2 MassAvg: 420.19 MassMono: 420.186498 Origin: C Source: artifact TermSpec: none Unimod: Unimod:984 S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl Native cysteine-reactive Tandem Mass Tag(TM) cysTMT A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-126 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) MOD:01823 The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. cysTMT6plex-126 reporter+balance reagent cysteine disulfide MOD:01823 A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-126 reporter+balance group. PubMed:18688235 URL:http://www.piercenet.com/files/2162220.pdf DiffAvg: 304.18 DiffFormula: (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono: 304.177202 Formula: (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg: 425.20 MassMono: 425.196952 Origin: C Source: artifact TermSpec: none Unimod: Unimod:985 S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-127 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) MOD:01824 The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. cysTMT6plex-127 reporter+balance reagent cysteine disulfide MOD:01824 A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-127 reporter+balance group. PubMed:18688235 URL:http://www.piercenet.com/files/2162220.pdf DiffAvg: 304.18 DiffFormula: (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono: 304.177202 Formula: (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg: 425.20 MassMono: 425.196952 Origin: C Source: artifact TermSpec: none S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-128 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) MOD:01825 The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. cysTMT6plex-128 reporter+balance reagent cysteine disulfide MOD:01825 A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-128 reporter+balance group. PubMed:18688235 URL:http://www.piercenet.com/files/2162220.pdf DiffAvg: 304.18 DiffFormula: (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono: 304.177202 Formula: (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg: 425.20 MassMono: 425.196952 Origin: C Source: artifact TermSpec: none S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-129 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) MOD:01826 The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. cysTMT6plex-129 reporter+balance reagent cysteine disulfide MOD:01826 A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-129 reporter+balance group. PubMed:18688235 URL:http://www.piercenet.com/files/2162220.pdf DiffAvg: 304.18 DiffFormula: (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono: 304.177202 Formula: (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg: 425.20 MassMono: 425.196952 Origin: C Source: artifact TermSpec: none S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-130 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) MOD:01827 The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. cysTMT6plex-130 reporter+balance reagent cysteine disulfide MOD:01827 A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-130 reporter+balance group. PubMed:18688235 URL:http://www.piercenet.com/files/2162220.pdf DiffAvg: 304.18 DiffFormula: (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono: 304.177202 Formula: (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg: 425.20 MassMono: 425.196952 Origin: C Source: artifact TermSpec: none S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-131 reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl PSI-MOD cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) MOD:01828 The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. cysTMT6plex-131 reporter+balance reagent cysteine disulfide MOD:01828 A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-131 reporter+balance group. PubMed:18688235 URL:http://www.piercenet.com/files/2162220.pdf DiffAvg: 304.18 DiffFormula: (12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1 DiffMono: 304.177202 Formula: (12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2 MassAvg: 425.20 MassMono: 425.196952 Origin: C Source: artifact TermSpec: none S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl cysTMT6plex cysteine-reactive Sixplex Tandem Mass Tag(TM) A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfoxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: CmCO PSI-MOD MOD:01829 S-carboxymethyl-L-cysteine sulfoxide MOD:01829 A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfoxide. PubMed:17689096 PubMed:18688235 DiffAvg: 58.04 DiffFormula: C 2 H 2 N 0 O 2 S 0 DiffMono: 58.005479 Formula: C 5 H 7 N 1 O 3 S 1 MassAvg: 161.18 MassMono: 161.014664 Origin: C Source: artifact TermSpec: none CmCO A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: CmCO2 PSI-MOD MOD:01830 S-carboxymethyl-L-cysteine sulfone MOD:01830 A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfone. PubMed:18688235 DiffAvg: 74.03 DiffFormula: C 2 H 2 N 0 O 3 S 0 DiffMono: 74.000394 Formula: C 5 H 7 N 1 O 4 S 1 MassAvg: 177.17 MassMono: 177.009579 Origin: C Source: artifact TermSpec: none CmCO2 A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: CamCO2 S-carbamoylmethyl-L-cysteine sulfone PSI-MOD MOD:01831 S-carboxamidomethyl-L-cysteine sulfone MOD:01831 A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfone. PubMed:18688235 DiffAvg: 89.05 DiffFormula: C 2 H 3 N 1 O 3 DiffMono: 89.011293 Formula: C 5 H 8 N 2 O 4 S 1 MassAvg: 192.19 MassMono: 192.020478 Origin: C Source: artifact TermSpec: none CamCO2 S-carbamoylmethyl-L-cysteine sulfone A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C-labeled residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 13C(5) Silac label Label:13C(5) MOD:01832 5x(13)C-labeled residue MOD:01832 A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C-labeled residue. PubMed:12771378 Unimod:772 DiffAvg: 5.02 DiffFormula: (12)C -5 (13)C 5 DiffMono: 5.016774 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:772 13C(5) Silac label Label:13C(5) A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01833 5x(13)C-labeled L-methionine MOD:01833 A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine. PubMed:18688235 url: DiffAvg: 5.02 DiffFormula: (12)C -5 (13)C 5 H 0 N 0 O 0 S 0 DiffMono: 5.016774 Formula: (13)C 5 H 9 N 1 O 1 S 1 MassAvg: 136.06 MassMono: 136.057259 Origin: M Source: artifact TermSpec: none A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfoxide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01834 5x(13)C-labeled L-methionine sulfoxide MOD:01834 A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfoxide. PubMed:18688235 DiffAvg: 5.02 DiffFormula: (12)C -5 (13)C 5 H 0 N 0 O 0 S 0 DiffMono: 5.016774 Formula: (13)C 5 H 9 N 1 O 2 S 1 MassAvg: 152.05 MassMono: 152.052174 Origin: MOD:00719 Source: artifact TermSpec: none A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfone. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01835 5x(13)C-labeled L-methionine sulfone MOD:01835 A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfone. PubMed:18688235 DiffAvg: 5.02 DiffFormula: (12)C -5 (13)C 5 H 0 N 0 O 0 S 0 DiffMono: 5.016774 Formula: (13)C 5 H 9 N 1 O 3 S 1 MassAvg: 168.05 MassMono: 168.047088 Origin: MOD:00256 Source: artifact TermSpec: none A protein modification that effectively converts an L-lysine residue to N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-[([1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]carbonyl)amino]hexanoic acid [(alpha-methyl-6-nitro-piperonyloxy)carbonyl]lysine PSI-MOD MOD:01836 N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine MOD:01836 A protein modification that effectively converts an L-lysine residue to N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine. PubMed:18688235 PubMed:20218600 PubMed:21271704 DiffAvg: 237.17 DiffFormula: C 10 H 7 N 1 O 6 DiffMono: 237.027337 Formula: C 16 H 19 N 3 O 7 MassAvg: 365.34 MassMono: 365.122300 Origin: K Source: artifact TermSpec: none (2S)-2-amino-6-[([1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]carbonyl)amino]hexanoic acid [(alpha-methyl-6-nitro-piperonyloxy)carbonyl]lysine A protein modification that effectively cross-links two L-cysteine residues with a thioether bond to form L-lanthionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) (R)-S-(2-amino-2-carboxyethyl)-L-cysteine (R,R)-2,6-diamino-4-thiaheptanedioic acid (R,R)-3,3'-thiobis-(2-aminopropanoic acid) (R,R)-bis(2-amino-2-carboxyethyl)sulfide 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid 3,3'-thiobis-L-alanine L-lanthionine PSI-MOD MOD:01837 Cross-link 2. L-lanthionine (Cys-Cys) MOD:01837 A protein modification that effectively cross-links two L-cysteine residues with a thioether bond to form L-lanthionine. ChEBI:21347 PubMed:20805503 PubMed:6007887 RESID:AA0110#CYS2 DiffAvg: -34.08 DiffFormula: C 0 H -2 N 0 O 0 S -1 DiffMono: -33.987721 Formula: C 6 H 8 N 2 O 2 S 1 MassAvg: 172.20 MassMono: 172.030649 Origin: C, C Source: hypothetical TermSpec: none (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) (R)-S-(2-amino-2-carboxyethyl)-L-cysteine (R,R)-2,6-diamino-4-thiaheptanedioic acid (R,R)-3,3'-thiobis-(2-aminopropanoic acid) (R,R)-bis(2-amino-2-carboxyethyl)sulfide 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid 3,3'-thiobis-L-alanine L-lanthionine A protein modification that effectively converts an L-lysine residue to L-lysinoalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0439 (2R,9S)-lysinoalanine (2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid L-lysinoalanine LAL MOD_RES Lysino-D-alanine (Lys) N-epsilon-(2-amino-2-carboxyethyl)-L-lysine N6-(2-amino-2-carboxyethyl)-L-lysine alaninolysine lysino-D-alanine PSI-MOD MOD:01838 This entry is for the modification of peptidyl lysine by a free serine. For the crosslink of peptidyl serine and peptidyl lysine see MOD:00132. L-lysinoalanine (Lys) MOD:01838 A protein modification that effectively converts an L-lysine residue to L-lysinoalanine. PubMed:19155267 PubMed:2544544 RESID:AA0123#LYS DiffAvg: 87.08 DiffFormula: C 3 H 5 N 1 O 2 DiffMono: 87.032028 Formula: C 9 H 17 N 3 O 3 MassAvg: 215.25 MassMono: 215.126991 Origin: K Source: natural TermSpec: none (2R,9S)-lysinoalanine (2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid L-lysinoalanine LAL MOD_RES Lysino-D-alanine (Lys) N-epsilon-(2-amino-2-carboxyethyl)-L-lysine N6-(2-amino-2-carboxyethyl)-L-lysine alaninolysine lysino-D-alanine A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01839 Cross-link 2. For the natural form of the lanthionine cross-link see MOD:00120 meso-lanthionine [JSG]. L-lanthionine MOD:01839 A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. PubMed:18688235 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 6 H 8 N 2 O 2 S 1 MassAvg: 172.20 MassMono: 172.030649 Origin: C, X Source: artifact TermSpec: none A protein modification that effectively converts an L-isoleucine residue to L-allo-isoleucine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0442 (2S,3R)-2-amino-3-methylpentanoic acid 2-azanyl-3-methylpentanoic acid 3-methyl-norvaline L-allo-isoleucine L-threo-isoleucine MOD_RES L-allo-isoleucine allo-L-isoleucine alpha-amino-beta-methylvaleric acid PSI-MOD MOD:01840 L-allo-isoleucine MOD:01840 A protein modification that effectively converts an L-isoleucine residue to L-allo-isoleucine. ChEBI:43433 PubMed:20805503 RESID:AA0546 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 6 H 11 N 1 O 1 MassAvg: 113.16 MassMono: 113.084064 Origin: I Source: natural TermSpec: none (2S,3R)-2-amino-3-methylpentanoic acid 2-azanyl-3-methylpentanoic acid 3-methyl-norvaline L-allo-isoleucine L-threo-isoleucine MOD_RES L-allo-isoleucine allo-L-isoleucine alpha-amino-beta-methylvaleric acid A protein modification that effectively cross-links either two or an L-cysteine residue and an L-serine residue by a thioether bond to form a lanthionine, either D- or L- or meso-lanthionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,6-diamino-4-thiaheptanedioic acid 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid 3,3'-thiobis-(2-aminopropanoic acid) 3,3'-thiobis-L-alanine S-(2-amino-2-carboxyethyl)-L-cysteine bis(2-amino-2-carboxyethyl)sulfanediyl bis(2-amino-2-carboxyethyl)sulfide PSI-MOD MOD:01841 Cross-link 2. [JSG]. lanthionine MOD:01841 A protein modification that effectively cross-links either two or an L-cysteine residue and an L-serine residue by a thioether bond to form a lanthionine, either D- or L- or meso-lanthionine. PubMed:18688235 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 6 H 8 N 2 O 2 S 1 MassAvg: 172.20 MassMono: 172.030649 Origin: C, X Source: artifact TermSpec: none 2,6-diamino-4-thiaheptanedioic acid 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid 3,3'-thiobis-(2-aminopropanoic acid) 3,3'-thiobis-L-alanine S-(2-amino-2-carboxyethyl)-L-cysteine bis(2-amino-2-carboxyethyl)sulfanediyl bis(2-amino-2-carboxyethyl)sulfide A protein modification that effectively converts two L-cysteine residues to S-(2-aminovinyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0443 (2R)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid (R,Z)-S-(2-aminovinyl)cysteine S-(2-aminovinyl)-L-cysteine PSI-MOD MOD:01842 Cross-link 2. S-(2-aminovinyl)-L-cysteine MOD:01842 A protein modification that effectively converts two L-cysteine residues to S-(2-aminovinyl)-L-cysteine. PubMed:20805503 RESID:AA0548 DiffAvg: -80.10 DiffFormula: C -1 H -4 N 0 O -2 S -1 DiffMono: -79.993200 Formula: C 5 H 7 N 2 O 1 S 1 MassAvg: 143.18 MassMono: 143.027909 Origin: C, C Source: natural TermSpec: C-term (2R)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid (R,Z)-S-(2-aminovinyl)cysteine S-(2-aminovinyl)-L-cysteine A protein modification that effectively converts an L-tryptophan residue to 5'-chloro-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0444 (2S)-2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid 5'-chloro-L-tryptophan MOD_RES 5'-chlorotryptophan PSI-MOD MOD:01843 5'-chloro-L-tryptophan MOD:01843 A protein modification that effectively converts an L-tryptophan residue to 5'-chloro-L-tryptophan. PubMed:18215770 RESID:AA0549 DiffAvg: 34.44 DiffFormula: C 0 Cl 1 H -1 N 0 O 0 DiffMono: 33.961028 Formula: C 11 Cl 1 H 9 N 2 O 1 MassAvg: 220.66 MassMono: 220.040341 Origin: W Source: natural TermSpec: none (2S)-2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid 5'-chloro-L-tryptophan MOD_RES 5'-chlorotryptophan A protein modification that effectively converts an L-cysteine residue and an L-leucine residue to 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0448 (4Z)-4-[hydroxy(sulfanyl)methylidene]-2-(3-methylbutanoyl)-1,3-oxazol-5(4H)-one [tautomer] 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid 5-hydroxy-2-(3-methylbutanoyl)-1,3-oxazole-4-carbothioic O-acid MOD_RES 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid (Leu-Cys) PSI-MOD MOD:01844 Cross-link 2. 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid MOD:01844 A protein modification that effectively converts an L-cysteine residue and an L-leucine residue to 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid. PubMed:15361623 PubMed:18729522 PubMed:20961038 PubMed:21254756 RESID:AA0550 DiffAvg: -5.06 DiffFormula: C 0 H -7 N -1 O 1 S 0 DiffMono: -5.062935 Formula: C 9 H 10 N 1 O 3 S 1 MassAvg: 212.24 MassMono: 212.038139 Origin: C, L Source: natural TermSpec: N-term (4Z)-4-[hydroxy(sulfanyl)methylidene]-2-(3-methylbutanoyl)-1,3-oxazol-5(4H)-one [tautomer] 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid 5-hydroxy-2-(3-methylbutanoyl)-1,3-oxazole-4-carbothioic O-acid MOD_RES 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid (Leu-Cys) A protein modification that effectively converts an L-cysteine residue and an L-proline residue to L-proline 5-hydroxyoxazole-4-carbothionic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0449 (4Z)-4-[hydroxy(sulfanyl)methylidene]-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazol-5(4H)-one [tautomer] 5-hydroxy-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazole-4-carbothioic O-acid CROSSLNK Proline 5-hydroxy-oxazole-4-carbothionic acid (Pro-Cys) L-proline 5-hydroxy-oxazole-4-carbothionic acid PSI-MOD MOD:01845 Cross-link 2. L-proline 5-hydroxyoxazole-4-carbothionic acid MOD:01845 A protein modification that effectively converts an L-cysteine residue and an L-proline residue to L-proline 5-hydroxyoxazole-4-carbothionic acid. PubMed:15361623 PubMed:18729522 PubMed:20961038 PubMed:21254756 RESID:AA0551 DiffAvg: -4.03 DiffFormula: C 0 H -4 N 0 O 0 S 0 DiffMono: -4.031300 Formula: C 8 H 8 N 2 O 2 S 1 MassAvg: 196.22 MassMono: 196.030649 Origin: C, P Source: natural TermSpec: none (4Z)-4-[hydroxy(sulfanyl)methylidene]-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazol-5(4H)-one [tautomer] 5-hydroxy-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazole-4-carbothioic O-acid CROSSLNK Proline 5-hydroxy-oxazole-4-carbothionic acid (Pro-Cys) L-proline 5-hydroxy-oxazole-4-carbothionic acid A protein modification that effectively converts two L-cysteine residues, and a copper atom to the methanobactin OB3b copper complex. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL copper [Cu-methanobactin OB3b complex] bis[4-(hydroxy[sulfanyl-kappaS]methylidene)-1,3-oxazol-5(4H)-onato-kappaN]copper methanobactin OB3b copper complex PSI-MOD MOD:01846 Cross-link 2. methanobactin OB3b copper complex MOD:01846 A protein modification that effectively converts two L-cysteine residues, and a copper atom to the methanobactin OB3b copper complex. PubMed:15361623 PubMed:18729522 PubMed:20961038 PubMed:21254756 RESID:AA0552 DiffAvg: 85.46 DiffFormula: C 0 Cu 1 H -10 N 0 O 2 S 0 DiffMono: 84.841176 Formula: C 6 Cu 1 H 0 N 2 O 4 S 2 MassAvg: 291.74 MassMono: 290.859546 Origin: C, C Source: natural TermSpec: N-term METAL copper [Cu-methanobactin OB3b complex] bis[4-(hydroxy[sulfanyl-kappaS]methylidene)-1,3-oxazol-5(4H)-onato-kappaN]copper methanobactin OB3b copper complex A protein modification that effectively converts an L-cysteine residue to L-cysteine sulfinyl phosphate. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-[(phosphonooxy)sulfinyl]propanoic acid L-cysteine sulfinyl phosphate cysteine sulfinic phosphoryl ester PSI-MOD MOD:01847 L-cysteine sulfinyl phosphate MOD:01847 A protein modification that effectively converts an L-cysteine residue to L-cysteine sulfinyl phosphate. PubMed:16565085 RESID:AA0557 DiffAvg: 111.98 DiffFormula: C 0 H 1 N 0 O 5 P 1 S 0 DiffMono: 111.956160 Formula: C 3 H 6 N 1 O 6 P 1 S 1 MassAvg: 215.12 MassMono: 214.965345 Origin: C Source: hypothetical TermSpec: none (2R)-2-amino-3-[(phosphonooxy)sulfinyl]propanoic acid L-cysteine sulfinyl phosphate cysteine sulfinic phosphoryl ester A protein modification that effectively converts an L-cysteine residue to S-(spermidinoglutathion-S-yl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-3-([(2R)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-2-([2-([3-([4-aminobutyl]amino)propyl]carbamoyl)methyl]carbamoyl)ethyl]disulfanyl)propanoic acid L-gamma-glutamyl-[S-(L-cystein-S-yl)]-L-cysteinyl-N-{3-[(4-aminobutyl)amino]propyl}glycinamide S-(spermidinoglutathion-S-yl)-L-cysteine cysteine glutathionylspermidine disulfide PSI-MOD MOD:01848 S-(spermidinoglutathion-S-yl)-L-cysteine MOD:01848 A protein modification that effectively converts an L-cysteine residue to S-(spermidinoglutathion-S-yl)-L-cysteine. ChEBI:16613 PubMed:20530482 RESID:AA0558 DiffAvg: 432.54 DiffFormula: C 17 H 32 N 6 O 5 S 1 DiffMono: 432.215489 Formula: C 20 H 37 N 7 O 6 S 2 MassAvg: 535.68 MassMono: 535.224674 Origin: C Source: natural TermSpec: none (2R)-2-amino-3-([(2R)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-2-([2-([3-([4-aminobutyl]amino)propyl]carbamoyl)methyl]carbamoyl)ethyl]disulfanyl)propanoic acid L-gamma-glutamyl-[S-(L-cystein-S-yl)]-L-cysteinyl-N-{3-[(4-aminobutyl)amino]propyl}glycinamide S-(spermidinoglutathion-S-yl)-L-cysteine cysteine glutathionylspermidine disulfide A protein modification that effectively cross-links two L-cysteine residues by a thioether bond to form S-(2-aminovinyl)-D-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0446 (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid (S,Z)-S-(2-aminovinyl)cysteine CROSSLNK S-(2-aminovinyl)-D-cysteine (Cys-Cys) S-(2-aminovinyl)-D-cysteine PSI-MOD MOD:01849 Cross-link 2. S-(2-aminovinyl)-D-cysteine (Cys-Cys) MOD:01849 A protein modification that effectively cross-links two L-cysteine residues by a thioether bond to form S-(2-aminovinyl)-D-cysteine. PubMed:20805503 RESID:AA0204#CYS2 DiffAvg: -80.10 DiffFormula: C -1 H -4 N 0 O -2 S -1 DiffMono: -79.993200 Formula: C 5 H 7 N 2 O 1 S 1 MassAvg: 143.18 MassMono: 143.027909 Origin: C, C Source: natural TermSpec: C-term (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid (S,Z)-S-(2-aminovinyl)cysteine CROSSLNK S-(2-aminovinyl)-D-cysteine (Cys-Cys) S-(2-aminovinyl)-D-cysteine A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid (S,Z)-S-(2-aminovinyl)cysteine S-(2-aminovinyl)-D-cysteine PSI-MOD MOD:01850 Cross-link 2. S-(2-aminovinyl)-D-cysteine MOD:01850 A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine. RESID:AA0204 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 5 H 7 N 2 O 1 S 1 MassAvg: 143.18 MassMono: 143.027909 Origin: C, X Source: natural TermSpec: C-term (2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid (S,Z)-S-(2-aminovinyl)cysteine S-(2-aminovinyl)-D-cysteine A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-amino-3-([2-aminoethenyl]sulfanyl)propanoic acid PSI-MOD MOD:01851 Cross-link 2. S-(2-aminovinyl)-cysteine MOD:01851 A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-cysteine. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 5 H 7 N 2 O 1 S 1 MassAvg: 143.18 MassMono: 143.027909 Origin: C, X Source: natural TermSpec: C-term 2-amino-3-([2-aminoethenyl]sulfanyl)propanoic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to release hydrogen sulfide and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Lysinoalanine (from Cysteine) PSI-MOD MOD:01852 Cross-link 2. This entry is for a crosslink of peptidyl cysteine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34 with no citation or formula. [JSG] L-lysinoalanine (Lys-Cys) MOD:01852 A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to release hydrogen sulfide and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid. DeltaMass:0 DiffAvg: -34.08 DiffFormula: C 0 H -2 N 0 O 0 S -1 DiffMono: -33.987721 Formula: C 9 H 15 N 3 O 2 MassAvg: 197.24 MassMono: 197.116427 Origin: C, K Source: hypothetical TermSpec: none Lysinoalanine (from Cysteine) A protein modification that effectively converts an L-lysine residue to L-lysinoalanine either by forming a cross-link with peptidyl-cysteine or peptidyl-serine, or by condensation with free serine. Origin: Source: TermSpec: PSI-MOD MOD:01853 L-lysinoalanine MOD:01853 A protein modification that effectively converts an L-lysine residue to L-lysinoalanine either by forming a cross-link with peptidyl-cysteine or peptidyl-serine, or by condensation with free serine. PubMed:18688235 Origin: K Source: natural TermSpec: none A protein modification that effectively adds one oxygen atom to a sulfur atom of a residue without removing hydrogen atoms. PSI-MOD MOD:01854 sulfur monooxygenated residue MOD:01854 A protein modification that effectively adds one oxygen atom to a sulfur atom of a residue without removing hydrogen atoms. PubMed:18688235 A protein modification that effectively adds two oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms. PSI-MOD MOD:01855 sulfur dioxygenated residue MOD:01855 A protein modification that effectively adds two oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms. PubMed:18688235 A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid. PSI-MOD MOD:01856 oxazole/oxazoline ring crosslinked residues (Cys) MOD:01856 A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid. PubMed:18688235 A protein modification that effectively cross-links an L-cysteine residue and an L-methionine residue by a thioether bond to form 2-(L-cystein-S-yl)-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0495 (2R)-2-amino-2-([2-amino-2-carboxyethyl]sulfanyl)-4-(methylsulfanyl)butanoic acid 2-(L-cystein-S-yl)-methionine CROSSLNK 2-(S-cysteinyl)-methionine (Cys-Met) PSI-MOD MOD:01857 Cross-link 2. The chirality around the methionine alpha-carbon has not been determined. 2-(L-cystein-S-yl)-methionine MOD:01857 A protein modification that effectively cross-links an L-cysteine residue and an L-methionine residue by a thioether bond to form 2-(L-cystein-S-yl)-methionine. PubMed:20805502 RESID:AA0559 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 8 H 12 N 2 O 2 S 2 MassAvg: 232.32 MassMono: 232.034020 Origin: C, M Source: natural TermSpec: none (2R)-2-amino-2-([2-amino-2-carboxyethyl]sulfanyl)-4-(methylsulfanyl)butanoic acid 2-(L-cystein-S-yl)-methionine CROSSLNK 2-(S-cysteinyl)-methionine (Cys-Met) A protein modification that effectively converts an L-cysteine residue to S-(N-acetylamino)glucosyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0628 (2R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosylsulfanyl)propanoic acid CARBOHYD S-linked (GlcNAc) cysteine S-(N-acetylamino)glucosyl-L-cysteine S-[(N-acetylamino)glycosyl]cysteine S-[beta-D-(N-acetylamino)glucopyranosyl]cysteine PSI-MOD MOD:01858 S-(N-acetylamino)glucosyl-L-cysteine MOD:01858 A protein modification that effectively converts an L-cysteine residue to S-(N-acetylamino)glucosyl-L-cysteine. ChEBI:61631 PubMed:21251913 PubMed:21395300 RESID:AA0560 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 S 0 DiffMono: 203.079373 Formula: C 11 H 18 N 2 O 6 S 1 MassAvg: 306.33 MassMono: 306.088557 Origin: C Source: natural TermSpec: none (2R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosylsulfanyl)propanoic acid CARBOHYD S-linked (GlcNAc) cysteine S-(N-acetylamino)glucosyl-L-cysteine S-[(N-acetylamino)glycosyl]cysteine S-[beta-D-(N-acetylamino)glucopyranosyl]cysteine A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form 4-amino-3-isothiazolidinone-L-phenylalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0451 (2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-phenylpropanoic acid 2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-phenylpropanoic acid 4-amino-3-isothiazolidinone-L-phenylalanine CROSSLNK N,N-(cysteine-1,S-diyl)phenylalanine (Cys-Phe) N,N-(L-cysteine-1,S-diyl)-L-phenylalanine cysteinyl phenylalanine sulfenamide phenylalanine-cysteine sulfenyl amide cross-link phenylalanine-cysteine sulphenyl amide cross-link PSI-MOD MOD:01859 Cross-link 2. 4-amino-3-isothiazolidinone-L-phenylalanine MOD:01859 A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form 4-amino-3-isothiazolidinone-L-phenylalanine. PubMed:17502599 RESID:AA0562 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 12 H 12 N 2 O 2 S 1 MassAvg: 248.30 MassMono: 248.061949 Origin: C, F Source: hypothetical TermSpec: none (2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-phenylpropanoic acid 2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-phenylpropanoic acid 4-amino-3-isothiazolidinone-L-phenylalanine CROSSLNK N,N-(cysteine-1,S-diyl)phenylalanine (Cys-Phe) N,N-(L-cysteine-1,S-diyl)-L-phenylalanine cysteinyl phenylalanine sulfenamide phenylalanine-cysteine sulfenyl amide cross-link phenylalanine-cysteine sulphenyl amide cross-link A protein modification that effectively converts an L-cysteine residue to L-cysteine bacillithiol disulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0452 (2S)-(2-[S-(L-cystein-S-yl)-L-cysteinyl]amino-2-deoxy-alpha-D-glucopyranosyloxy)-butanedioic acid BSH L-cysteine bacillithiol disulfide MOD_RES S-bacillithiol cysteine disulfide PSI-MOD MOD:01860 L-cysteine bacillithiol disulfide MOD:01860 A protein modification that effectively converts an L-cysteine residue to L-cysteine bacillithiol disulfide. ChEBI:61338 PubMed:19578333 RESID:AA0563 DiffAvg: 396.37 DiffFormula: C 13 H 20 N 2 O 10 S 1 DiffMono: 396.083866 Formula: C 16 H 25 N 3 O 11 S 2 MassAvg: 499.51 MassMono: 499.093051 Origin: C Source: natural TermSpec: none (2S)-(2-[S-(L-cystein-S-yl)-L-cysteinyl]amino-2-deoxy-alpha-D-glucopyranosyloxy)-butanedioic acid BSH L-cysteine bacillithiol disulfide MOD_RES S-bacillithiol cysteine disulfide A protein modification that crosslinks two residues by condensation of a cysteine thiol with the amido nitrogen of the following residue to form an isothiazolidinone ring. PSI-MOD MOD:01861 The isothiazolidinone ring is usually formed by the reaction of a cysteine sulfenic acid with the amido nitrogen releasing water. isothiazolidinone ring crosslinked residues MOD:01861 A protein modification that crosslinks two residues by condensation of a cysteine thiol with the amido nitrogen of the following residue to form an isothiazolidinone ring. PubMed:18688235 A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a substituted sulfanyl group, forming a disulfide bond that does not cross-link two encoded peptide chains. Origin: TermSpec: S-thiolation PSI-MOD MOD:01862 disulfide conjugated residue MOD:01862 A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a substituted sulfanyl group, forming a disulfide bond that does not cross-link two encoded peptide chains. PubMed:18688235 Origin: C TermSpec: none S-thiolation A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems mTRAQ reagent reporter+balance groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems mTRAQ(TM) reagent MOD:01863 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. mTRAQ reporter+balance reagent acylated residue MOD:01863 A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems mTRAQ reagent reporter+balance groups. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl Applied Biosystems mTRAQ(TM) reagent A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems mTRAQ light reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl PSI-MOD Applied Biosystems mTRAQ(TM) reagent mTRAQ heavy MOD:01864 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. mTRAQ light reporter+balance reagent acylated residue MOD:01864 A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems mTRAQ light reporter+balance group. Unimod:888 DiffAvg: 140.09 DiffFormula: (12)C 7 H 12 (14)N 2 (16)O 1 DiffMono: 140.094963 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:888 (4-methylpiperazin-1-yl)acetyl Applied Biosystems mTRAQ(TM) reagent mTRAQ heavy A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems mTRAQ light reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl mTRAQ light on nterm PSI-MOD Applied Biosystems mTRAQ(TM) reagent mTRAQ light MOD:01865 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. mTRAQ light reporter+balance reagent acylated N-terminal MOD:01865 A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems mTRAQ light reporter+balance group. OMSSA:208 Unimod:888#N-term DiffAvg: 140.09 DiffFormula: (12)C 7 H 12 (14)N 2 (16)O 1 DiffMono: 140.094963 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term Unimod: Unimod:888 (4-methylpiperazin-1-yl)acetyl mTRAQ light on nterm Applied Biosystems mTRAQ(TM) reagent mTRAQ light A protein modification that effectively replaces the N6-amino hydrogen atom of a lysine residue with the Applied Biosystems mTRAQ light reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl mTRAQ light on K PSI-MOD Applied Biosystems mTRAQ(TM) reagent mTRAQ light MOD:01866 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. mTRAQ light reporter+balance reagent N6-acylated lysine MOD:01866 A protein modification that effectively replaces the N6-amino hydrogen atom of a lysine residue with the Applied Biosystems mTRAQ light reporter+balance group. OMSSA:209 Unimod:888#K DiffAvg: 140.09 DiffFormula: (12)C 7 H 12 (14)N 2 (16)O 1 DiffMono: 140.094963 Formula: (12)C 13 H 24 N 2 (14)N 2 O 1 (16)O 1 MassAvg: 268.19 MassMono: 268.189926 Origin: K Source: artifact TermSpec: none Unimod: Unimod:888 (4-methylpiperazin-1-yl)acetyl mTRAQ light on K Applied Biosystems mTRAQ(TM) reagent mTRAQ light A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems mTRAQ light reporter+balance group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (4-methylpiperazin-1-yl)acetyl mTRAQ light on Y PSI-MOD Applied Biosystems mTRAQ(TM) reagent mTRAQ light MOD:01867 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. mTRAQ light reporter+balance reagent O4'-acylated tyrosine MOD:01867 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems mTRAQ light reporter+balance group. OMSSA:210 Unimod:888#Y DiffAvg: 140.09 DiffFormula: (12)C 7 H 12 (14)N 2 (16)O 1 DiffMono: 140.094963 Formula: (12)C 16 H 21 (14)N 3 O 2 (16)O 1 MassAvg: 303.16 MassMono: 303.158292 Origin: Y Source: artifact TermSpec: none Unimod: Unimod:888 (4-methylpiperazin-1-yl)acetyl mTRAQ light on Y Applied Biosystems mTRAQ(TM) reagent mTRAQ light Modifications that have monoisotopic mass differences from their respective origins of 140.094963 Da. PSI-MOD MOD:01868 modifications with monoisotopic mass differences that are nominally equal at 140.094963 Da MOD:01868 Modifications that have monoisotopic mass differences from their respective origins of 140.094963 Da. PubMed:18688235 The protein modification reporter fragment produced by an Applied Biosystems mTRAQ light reagent derivatized residue. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-methyl-1-methylidenepiperazin-1-ium PSI-MOD MOD:01869 mTRAQ light reporter fragment MOD:01869 The protein modification reporter fragment produced by an Applied Biosystems mTRAQ light reagent derivatized residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none FormalCharge: 1+ Formula: (12)C 6 H 13 (14)N 2 MassAvg: 113.11 MassMono: 113.107325 Origin: X Source: artifact TermSpec: none 4-methyl-1-methylidenepiperazin-1-ium A protein modification reporter fragment produced by an Applied Biosystems mTRAQ reagent derivatized residue. PSI-MOD MOD:01870 mTRAQ reporter fragment MOD:01870 A protein modification reporter fragment produced by an Applied Biosystems mTRAQ reagent derivatized residue. PubMed:18688235 A protein modification that effectively cyclizes an S-carboxamidomethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid 5-oxothiomorpholine-3-carboxylic acid Otc PSI-MOD Pyro-carbamidomethyl S-carbamoylmethylcysteine cyclization (N-terminus) MOD:01871 cyclized N-terminal S-carboxamidomethyl-L-cysteine MOD:01871 A protein modification that effectively cyclizes an S-carboxamidomethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of ammonia. DeltaMass:336 PubMed:12643538 Unimod:26 DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 S 0 DiffMono: -17.026549 Formula: C 5 H 6 N 1 O 2 S 1 MassAvg: 144.17 MassMono: 144.011924 Origin: MOD:01060 Source: artifact TermSpec: N-term Unimod: Unimod:26 (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid 5-oxothiomorpholine-3-carboxylic acid Otc Pyro-carbamidomethyl S-carbamoylmethylcysteine cyclization (N-terminus) A protein modification that effectively cyclizes an S-carboxymethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of water. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid 5-oxothiomorpholine-3-carboxylic acid Otc PSI-MOD Pyro-carbamidomethyl S-carbamoylmethylcysteine cyclization (N-terminus) MOD:01872 Contrary to the impression given in Unimod entry 26, the cyclization of N-terminal S-carboxymethyl-L-cysteine is not reported in PubMed:1263538. The cyclization would be expected to proceed under strongly acidic conditions [JSG]. cyclized N-terminal S-carboxymethyl-L-cysteine MOD:01872 A protein modification that effectively cyclizes an S-carboxymethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of water. PubMed:12643538 Unimod:26 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 5 H 6 N 1 O 2 S 1 MassAvg: 144.17 MassMono: 144.011924 Origin: MOD:01061 Source: artifact TermSpec: N-term Unimod: Unimod:26 (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid 5-oxothiomorpholine-3-carboxylic acid Otc Pyro-carbamidomethyl S-carbamoylmethylcysteine cyclization (N-terminus) A protein modification that effectively converts an L-alanine residue to N-carboxy-L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-carboxyamino-propanoic acid 2-carbamic-propanoic acid N-carboxymethionine PSI-MOD MOD:01873 This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. N-carboxy-L-alanine MOD:01873 A protein modification that effectively converts an L-alanine residue to N-carboxy-L-alanine. PubMed:18688235 PubMed:4593770 PubMed:4647257 PubMed:8312270 DiffAvg: 44.01 DiffFormula: C 1 H 0 N 0 O 2 DiffMono: 43.989829 Formula: C 4 H 6 N 1 O 3 MassAvg: 116.10 MassMono: 116.034768 Origin: A Source: natural TermSpec: N-term (S)-2-carboxyamino-propanoic acid 2-carbamic-propanoic acid N-carboxymethionine A protein modification that effectively converts an L-alanine residue to N-carboxy-L-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (S)-2-carboxyamino-propanoic acid 2-carbamic-propanoic acid N-carboxymethionine PSI-MOD MOD:01874 This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG]. N-carboxy-L-valine MOD:01874 A protein modification that effectively converts an L-alanine residue to N-carboxy-L-valine. PubMed:18688235 PubMed:4593770 PubMed:4647257 PubMed:8312270 DiffAvg: 44.01 DiffFormula: C 1 H 0 N 0 O 2 DiffMono: 43.989829 Formula: C 6 H 10 N 1 O 3 MassAvg: 144.15 MassMono: 144.066068 Origin: V Source: natural TermSpec: N-term (S)-2-carboxyamino-propanoic acid 2-carbamic-propanoic acid N-carboxymethionine A protein modification that effectively replaces an N6-amino hydrogen atom of L-lysine with an acyl group. Origin: Source: TermSpec: N6AcylLys PSI-MOD MOD:01875 N6-acylated L-lysine MOD:01875 A protein modification that effectively replaces an N6-amino hydrogen atom of L-lysine with an acyl group. PubMed:18688235 Origin: K Source: natural TermSpec: none N6AcylLys OBSOLETE because identical to MOD:00457 DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: PSI-MOD MOD:01876 4x(1)H,4x(12)C-labeled alpha-amino succinylated residue true MOD:01876 OBSOLETE because identical to MOD:00457 PubMed:18688235 DiffAvg: 100.02 DiffFormula: (12)C 4 (1)H 4 O 3 DiffMono: 100.016044 Formula: none MassAvg: none MassMono: none Origin: X Remap: MOD:00457 Source: artifact TermSpec: N-term A protein modification that effectively converts an L-cysteine residue and an L-arginine residue to 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0457 (4Z)-2-(4-guanidinobutanoyl)-5-oxo-4-(sulfanylmethylidene)-4,5-dihydro-1H-imidazole 2-(4-guanidinobutanoyl)-5-hydroxy-1H-imidazole-4-carbothioic O-acid 2-(4-guanidinobutanoyl)-5-hydroxy-4-thioformyl-1H-imidazole [tautomer] 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid CROSSLNK 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid (Arg-Cys) PSI-MOD MOD:01877 Cross-link 2. 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid MOD:01877 A protein modification that effectively converts an L-cysteine residue and an L-arginine residue to 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid. PubMed:20961038 RESID:AA0553 DiffAvg: -6.05 DiffFormula: C 0 H -6 N 0 O 0 S 0 DiffMono: -6.046950 Formula: C 9 H 12 N 5 O 2 S 1 MassAvg: 254.29 MassMono: 254.071171 Origin: C, R Source: natural TermSpec: N-term (4Z)-2-(4-guanidinobutanoyl)-5-oxo-4-(sulfanylmethylidene)-4,5-dihydro-1H-imidazole 2-(4-guanidinobutanoyl)-5-hydroxy-1H-imidazole-4-carbothioic O-acid 2-(4-guanidinobutanoyl)-5-hydroxy-4-thioformyl-1H-imidazole [tautomer] 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid CROSSLNK 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid (Arg-Cys) A protein modification that effectively converts an L-cysteine residue and an L-threonine residue to L-threonine 5-hydroxyoxazole-4-carbothionic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0458 (4Z)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-(sulfanylmethylidene)-1,3-oxazol-5(4H)-one [tautomer] 2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-hydroxy-1,3-oxazole-4-carbothioic O-acid CROSSLNK Threonine 5-hydroxy-oxazole-4-carbonthionic acid (Thr-Cys) L-threonine 5-hydroxy-oxazole-4-carbonthionic acid PSI-MOD MOD:01878 Cross-link 2. L-threonine 5-hydroxyoxazole-4-carbonthionic acid MOD:01878 A protein modification that effectively converts an L-cysteine residue and an L-threonine residue to L-threonine 5-hydroxyoxazole-4-carbothionic acid. PubMed:20961038 RESID:AA0554 DiffAvg: -4.03 DiffFormula: C 0 H -4 N 0 O 0 S 0 DiffMono: -4.031300 Formula: C 7 H 8 N 2 O 3 S 1 MassAvg: 200.21 MassMono: 200.025563 Origin: C, T Source: natural TermSpec: none (4Z)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-(sulfanylmethylidene)-1,3-oxazol-5(4H)-one [tautomer] 2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-hydroxy-1,3-oxazole-4-carbothioic O-acid CROSSLNK Threonine 5-hydroxy-oxazole-4-carbonthionic acid (Thr-Cys) L-threonine 5-hydroxy-oxazole-4-carbonthionic acid A protein modification that effectively converts two L-cysteine residues, an L-arginine residue, an L-threonine residue and a copper atom to the methanobactin SB2 copper complex. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL copper [Cu-methanobactin SB2 complex] [5-(hydroxy[sulfanyl-kappaS]methylene)-3,5-dihydro-4H-imidazol-4-onato-kappaN1][4-(hydroxy[sulfanyl-kappaS]methylene)-1,3-oxazol-5(4H)-onato-kappaN]copper methanobactin SB2 copper complex PSI-MOD MOD:01879 Cross-link 2. methanobactin SB2 copper complex MOD:01879 A protein modification that effectively converts two L-cysteine residues, an L-arginine residue, an L-threonine residue and a copper atom to the methanobactin SB2 copper complex. PubMed:20961038 RESID:AA0555 DiffAvg: 84.48 DiffFormula: C 0 Cu 1 H -9 N 1 O 1 S 0 DiffMono: 83.857161 Formula: C 6 Cu 1 H 1 N 3 O 3 S 2 MassAvg: 290.76 MassMono: 289.875530 Origin: C, C, R, T Source: natural TermSpec: N-term METAL copper [Cu-methanobactin SB2 complex] [5-(hydroxy[sulfanyl-kappaS]methylene)-3,5-dihydro-4H-imidazol-4-onato-kappaN1][4-(hydroxy[sulfanyl-kappaS]methylene)-1,3-oxazol-5(4H)-onato-kappaN]copper methanobactin SB2 copper complex modification from RESID DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0684 (2S)-2-amino-6-[(4-aminobutyl)amino]hexanoic acid L-deoxyhypusine MOD_RES Deoxyhypusine N6-(4-aminobutyl)lysine deoxyhypusine PSI-MOD MOD:01880 L-deoxyhypusine MOD:01880 modification from RESID ChEBI:50038 PubMed:16452303 RESID:AA0564 DiffAvg: 71.12 DiffFormula: C 4 H 9 N 1 O 0 DiffMono: 71.073499 Formula: C 10 H 21 N 3 O 1 MassAvg: 199.30 MassMono: 199.168462 Origin: K Source: natural TermSpec: none (2S)-2-amino-6-[(4-aminobutyl)amino]hexanoic acid L-deoxyhypusine MOD_RES Deoxyhypusine N6-(4-aminobutyl)lysine deoxyhypusine A protein modification that effectively crosslinks an L-phenylalanine residue and an L-valine residue by a free radical process effectively releasing a hydrogen molecule and forming 3-(L-phenylalan-2'-yl)-L-valine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-(2-[(2S)-2-amino-2-carboxyethyl]phenyl)-3-methylbutanoic acid 3-(L-phenylalan-2'-yl)-L-valine symerythrin valine-phenylalanine cross-link PSI-MOD MOD:01881 Cross-link 2. 3-(L-phenylalan-2'-yl)-L-valine MOD:01881 A protein modification that effectively crosslinks an L-phenylalanine residue and an L-valine residue by a free radical process effectively releasing a hydrogen molecule and forming 3-(L-phenylalan-2'-yl)-L-valine. PubMed:21596985 RESID:AA0565 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: C 14 H 16 N 2 O 2 MassAvg: 244.29 MassMono: 244.121178 Origin: F, V Source: natural TermSpec: none (2S)-2-amino-4-(2-[(2S)-2-amino-2-carboxyethyl]phenyl)-3-methylbutanoic acid 3-(L-phenylalan-2'-yl)-L-valine symerythrin valine-phenylalanine cross-link A protein modification that effectively crosslinks the carbonyl of an amino acid residue at position n with the alpha amino of a glycine residue at position n+2 to form a 5-imidazolinone ring. PSI-MOD MOD:01882 5-imidazolinone ring crosslinked residues (Gly) MOD:01882 A protein modification that effectively crosslinks the carbonyl of an amino acid residue at position n with the alpha amino of a glycine residue at position n+2 to form a 5-imidazolinone ring. PubMed:18688235 A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 5-imidazolinone ring. PSI-MOD MOD:01883 5-imidazolinone ring crosslinked residues (Cys) MOD:01883 A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 5-imidazolinone ring. PubMed:18688235 A protein modification that effectively replaces a hydrogen atom with a 4-aminobutyl group, usually derived from spermidine. Origin: TermSpec: PSI-MOD MOD:01884 4-aminobutylated residue MOD:01884 A protein modification that effectively replaces a hydrogen atom with a 4-aminobutyl group, usually derived from spermidine. PubMed:18688235 Origin: X TermSpec: none A protein modification that effectively replaces a hydrogen atom with a biotinyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl Biotinylation BtnRes PSI-MOD MOD:01885 biotinylated residue MOD:01885 A protein modification that effectively replaces a hydrogen atom with a biotinyl group. PubMed:18688235 DiffAvg: 226.29 DiffFormula: C 10 H 14 N 2 O 2 S 1 DiffMono: 226.077599 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none 5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl Biotinylation BtnRes A protein modification that effectively replaces a hydrogen atom with an sulfanyl or substituted sulfanyl group. Origin: TermSpec: PSI-MOD MOD:01886 thiolated residue MOD:01886 A protein modification that effectively replaces a hydrogen atom with an sulfanyl or substituted sulfanyl group. PubMed:18688235 Origin: X TermSpec: none A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A lysine adduct. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate N6UniblueALys Uniblue A PSI-MOD MOD:01887 Uniblue A derivatized lysine MOD:01887 A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A lysine adduct. PubMed:18688235 DiffAvg: 484.50 DiffFormula: C 22 H 16 N 2 O 7 S 2 DiffMono: 484.039893 Formula: C 28 H 28 N 4 O 8 S 2 MassAvg: 612.67 MassMono: 612.134856 Origin: K Source: artifact TermSpec: none 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate 1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate N6UniblueALys Uniblue A A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) from a residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: 2dHRes PSI-MOD MOD:01888 didehydrogenated residue MOD:01888 A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) from a residue. Unimod:401 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 DiffMono: -2.015650 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none Unimod: Unimod:401 2dHRes A protein modification that effectively converts an L-cysteine residue to S-(2-succinyl)-L-cysteine, by addition of either fumaric acid or maleic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0674 (2R)-2-amino-3-([(1R)-1,2-dicarboxyethyl]sulfanyl)propanoic acid (2R)-2-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanedioic acid 2-((2-amino-2-carboxyethyl)thio)butanedioic acid 2-amino-3-(1,2-dicarboxyethylthio)propanoic acid MOD_RES S-(2-succinyl)cysteine S-(1,2-dicarboxyethyl)cysteine S-(2-succinyl)-L-cysteine S-(2-succinyl)cysteine S-[(2R)-2-succinyl]-L-cysteine PSI-MOD MOD:01889 S-(2-succinyl)-L-cysteine MOD:01889 A protein modification that effectively converts an L-cysteine residue to S-(2-succinyl)-L-cysteine, by addition of either fumaric acid or maleic acid. PubMed:16624247 PubMed:18448829 PubMed:20677745 RESID:AA0561 Unimod:957 DiffAvg: 116.07 DiffFormula: C 4 H 4 N 0 O 4 S 0 DiffMono: 116.010959 Formula: C 7 H 9 N 1 O 5 S 1 MassAvg: 219.21 MassMono: 219.020143 Origin: C Source: natural TermSpec: none Unimod: Unimod:957 (2R)-2-amino-3-([(1R)-1,2-dicarboxyethyl]sulfanyl)propanoic acid (2R)-2-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanedioic acid 2-((2-amino-2-carboxyethyl)thio)butanedioic acid 2-amino-3-(1,2-dicarboxyethylthio)propanoic acid MOD_RES S-(2-succinyl)cysteine S-(1,2-dicarboxyethyl)cysteine S-(2-succinyl)-L-cysteine S-(2-succinyl)cysteine S-[(2R)-2-succinyl]-L-cysteine A protein modification that effectively crosslinks an N-formyl-L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid N-[(L-histidin-1'-yl)methyl]-L-methionine PSI-MOD MOD:01890 Cross-link 2. N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) MOD:01890 A protein modification that effectively crosslinks an N-formyl-L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine. PubMed:19622680 RESID:AA0566#FMET DiffAvg: -16.00 DiffFormula: C 0 H 0 N 0 O -1 S 0 DiffMono: -15.994915 Formula: C 12 H 17 N 4 O 2 S 1 MassAvg: 281.35 MassMono: 281.107222 Origin: H, MOD:00030 Source: hypothetical TermSpec: N-term (2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid N-[(L-histidin-1'-yl)methyl]-L-methionine A protein modification that effectively crosslinks an L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid N-[(L-histidin-1'-yl)methyl]-L-methionine PSI-MOD MOD:01891 Cross-link 2. N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) MOD:01891 A protein modification that effectively crosslinks an L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine. PubMed:19622680 RESID:AA0566#MET DiffAvg: 12.01 DiffFormula: C 1 H 0 N 0 O 0 S 0 DiffMono: 12.000000 Formula: C 12 H 17 N 4 O 2 S 1 MassAvg: 281.35 MassMono: 281.107222 Origin: H, M Source: hypothetical TermSpec: N-term (2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid N-[(L-histidin-1'-yl)methyl]-L-methionine A protein modification that effectively converts an L-lysine residue to N6-crotonyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0475 (2S)-2-amino-6-[(2E)-but-2-enamido]hexanoic acid (2S)-2-amino-6-[(2E)-but-2-enoylamino]hexanoic acid (2S)-2-azanyl-6-[(2E)-but-2-enoylazanyl]hexanoic acid MOD_RES N6-crotonyl-L-lysine N(epsilon)-crotonyllysine N6-(E)-crotonyllysine N6-[(2E)-2-butenoyl]-L-lysine N6-crotonyl-L-lysine N6-crotonyllysine N6-trans-crotonyllysine PSI-MOD MOD:01892 N6-crotonyl-L-lysine MOD:01892 A protein modification that effectively converts an L-lysine residue to N6-crotonyl-L-lysine. PubMed:21925322 RESID:AA0567 DiffAvg: 68.07 DiffFormula: C 4 H 4 N 0 O 1 DiffMono: 68.026215 Formula: C 10 H 16 N 2 O 2 MassAvg: 196.25 MassMono: 196.121178 Origin: K Source: hypothetical TermSpec: none (2S)-2-amino-6-[(2E)-but-2-enamido]hexanoic acid (2S)-2-amino-6-[(2E)-but-2-enoylamino]hexanoic acid (2S)-2-azanyl-6-[(2E)-but-2-enoylazanyl]hexanoic acid MOD_RES N6-crotonyl-L-lysine N(epsilon)-crotonyllysine N6-(E)-crotonyllysine N6-[(2E)-2-butenoyl]-L-lysine N6-crotonyl-L-lysine N6-crotonyllysine N6-trans-crotonyllysine A protein modification that effectively converts an L-lysine residue to N6-malonyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0467 (2S)-2-amino-6-[(carboxyacetyl)amino]hexanoic acid 2-azanyl-6-[(carboxyacetyl)azanyl]hexanoic acid MOD_RES N6-malonyllysine N(epsilon)-(malonyl)lysine N6-(carboxyacetyl)lysine N6-malonyl-L-lysine N6-malonyllysine malonyllysine PSI-MOD MOD:01893 N6-malonyl-L-lysine MOD:01893 A protein modification that effectively converts an L-lysine residue to N6-malonyl-L-lysine. PubMed:21908771 PubMed:8349414 RESID:AA0568 DiffAvg: 86.05 DiffFormula: C 3 H 2 N 0 O 3 DiffMono: 86.000394 Formula: C 9 H 14 N 2 O 4 MassAvg: 214.22 MassMono: 214.095357 Origin: K Source: hypothetical TermSpec: none (2S)-2-amino-6-[(carboxyacetyl)amino]hexanoic acid 2-azanyl-6-[(carboxyacetyl)azanyl]hexanoic acid MOD_RES N6-malonyllysine N(epsilon)-(malonyl)lysine N6-(carboxyacetyl)lysine N6-malonyl-L-lysine N6-malonyllysine malonyllysine A protein modification that effectively replaces a hydrogen atom with an propanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Propionate labeling reagent light form (N-term & K) Propionyl MOD:01894 propanoylated residue MOD:01894 A protein modification that effectively replaces a hydrogen atom with an propanoyl group. PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:58 DiffAvg: 56.06 DiffFormula: C 3 H 4 O 1 DiffMono: 56.026215 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:58 Propionate labeling reagent light form (N-term & K) Propionyl A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(12)C-labeled propanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Propionate labeling reagent light form (N-term & K) Propionyl MOD:01895 alpha-amino 3x(12)C-labeled propanoylated residue MOD:01895 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(12)C-labeled propanoyl group. PubMed:11857757 PubMed:11999733 PubMed:12175151 Unimod:58#N-term DiffAvg: 56.03 DiffFormula: (12)C 3 H 4 O 1 DiffMono: 56.026215 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:58 Propionate labeling reagent light form (N-term & K) Propionyl A protein modification produced by trifluoroacetic acid forming an adduct, either a salt or a hydrogen bonded carboxylic acid dimer, with an amino acid residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: TFA PSI-MOD MOD:01896 Trifluoroacetic acid has been observed to form adducts in both negative and positive mode analysis (Mark Collins, private communication) [JSG]. trifluoroacetic acid adduct MOD:01896 A protein modification produced by trifluoroacetic acid forming an adduct, either a salt or a hydrogen bonded carboxylic acid dimer, with an amino acid residue. PubMed:18688235 DiffAvg: 114.02 DiffFormula: C 2 F 3 H 1 O 2 DiffMono: 113.992864 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none TFA A protein modification that effectively converts an L-isoleucine residue to 5-hydroxy-3-methyl-L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0466 (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid 5-hydroxy-3-methyl-L-proline 5-hydroxy-3-methylproline 5Hy3MePro(Ile) MOD_RES 5-hydroxy-3-methylproline (Ile) beta-methyl-delta-hydroxyproline PSI-MOD MOD:01897 5-hydroxy-3-methyl-L-proline (Ile) MOD:01897 A protein modification that effectively converts an L-isoleucine residue to 5-hydroxy-3-methyl-L-proline. PubMed:21788474 PubMed:7592021 PubMed:8557573 RESID:AA0473 DiffAvg: 13.98 DiffFormula: C 0 H -2 N 0 O 1 DiffMono: 13.979265 Formula: C 6 H 9 N 1 O 2 MassAvg: 127.14 MassMono: 127.063329 Origin: I Source: natural TermSpec: none (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid 5-hydroxy-3-methyl-L-proline 5-hydroxy-3-methylproline 5Hy3MePro(Ile) MOD_RES 5-hydroxy-3-methylproline (Ile) beta-methyl-delta-hydroxyproline modification from RESID DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0459 (2S)-5-[(diaminomethylidene)amino]-2-(dimethylamino)pentanoic acid (2S)-5-carbamimidamido-2-(dimethylamino)pentanoic acid [tautomer] MOD_RES N2,N2-dimethylarginine N(alpha),N(alpha)-dimethylarginine N2,N2-dimethyl-L-arginine N2,N2-dimethylarginine PSI-MOD MOD:01898 N2,N2-dimethyl-L-arginine MOD:01898 modification from RESID PubMed:21568297 PubMed:21950656 RESID:AA0569 DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 8 H 17 N 4 O 1 MassAvg: 185.25 MassMono: 185.140236 Origin: R Source: natural TermSpec: N-term (2S)-5-[(diaminomethylidene)amino]-2-(dimethylamino)pentanoic acid (2S)-5-carbamimidamido-2-(dimethylamino)pentanoic acid [tautomer] MOD_RES N2,N2-dimethylarginine N(alpha),N(alpha)-dimethylarginine N2,N2-dimethyl-L-arginine N2,N2-dimethylarginine A protein modification that effectively crosslinks an L-arginine residue and an L-cysteine residue to form arginine thiazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0460 2-[(1S)-1-amino-4-([diaminomethylidene]amino)butyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Arg-Cys) L-arginine thiazole-4-carboxylic acid PSI-MOD MOD:01899 Cross-link 2. L-arginine thiazole-4-carboxylic acid MOD:01899 A protein modification that effectively crosslinks an L-arginine residue and an L-cysteine residue to form arginine thiazole-4-carboxylic acid. PubMed:21568297 PubMed:21950656 RESID:AA0570 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 9 H 13 N 5 O 1 S 1 MassAvg: 239.30 MassMono: 239.084081 Origin: C, R Source: natural TermSpec: none 2-[(1S)-1-amino-4-([diaminomethylidene]amino)butyl]-1,3-thiazole-4-carboxylic acid CROSSLNK Thiazole-4-carboxylic acid (Arg-Cys) L-arginine thiazole-4-carboxylic acid A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-cysteine 5-methyloxazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0461 2-[(1R)-1-amino-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid 2-[(1R)-1-azanyl-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid CROSSLNK 5-methyloxazole-4-carboxylic acid (Cys-Thr) L-cysteine 5-methyloxazole-4-carboxylic acid PSI-MOD MOD:01900 Cross-link 2. L-cysteine 5-methyloxazole-4-carboxylic acid MOD:01900 A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-cysteine 5-methyloxazole-4-carboxylic acid. PubMed:21568297 PubMed:21950656 RESID:AA0571 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 S 0 DiffMono: -20.026215 Formula: C 7 H 8 N 2 O 2 S 1 MassAvg: 184.21 MassMono: 184.030649 Origin: C, T Source: natural TermSpec: none 2-[(1R)-1-amino-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid 2-[(1R)-1-azanyl-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid CROSSLNK 5-methyloxazole-4-carboxylic acid (Cys-Thr) L-cysteine 5-methyloxazole-4-carboxylic acid A protein modification that effectively crosslinks two L-threonine residues to form L-threonine 5-methyloxazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0462 2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid 2-[(1S,2R)-1-azanyl-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid CROSSLNK 5-methyloxazole-4-carboxylic acid (Thr-Thr) L-threonine 5-methyloxazole-4-carboxylic acid PSI-MOD MOD:01901 Cross-link 2. L-threonine 5-methyloxazole-4-carboxylic acid MOD:01901 A protein modification that effectively crosslinks two L-threonine residues to form L-threonine 5-methyloxazole-4-carboxylic acid. PubMed:21568297 PubMed:21950656 RESID:AA0572 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 DiffMono: -20.026215 Formula: C 8 H 10 N 2 O 3 MassAvg: 182.18 MassMono: 182.069142 Origin: T, T Source: natural TermSpec: none 2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid 2-[(1S,2R)-1-azanyl-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid CROSSLNK 5-methyloxazole-4-carboxylic acid (Thr-Thr) L-threonine 5-methyloxazole-4-carboxylic acid A protein modification that effectively crosslinks an L-isoleucine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0463 2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-oxazole-4-carboxylic acid 2-[(1S,2S)-1-azanyl-2-methylbutyl]-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazole-4-carboxylic acid (Ile-Ser) L-isoleucine oxazole-4-carboxylic acid PSI-MOD MOD:01902 Cross-link 2. L-isoleucine oxazole-4-carboxylic acid MOD:01902 A protein modification that effectively crosslinks an L-isoleucine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid. PubMed:21568297 PubMed:21950656 RESID:AA0573 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 DiffMono: -20.026215 Formula: C 9 H 12 N 2 O 2 MassAvg: 180.21 MassMono: 180.089878 Origin: I, S Source: natural TermSpec: none 2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-oxazole-4-carboxylic acid 2-[(1S,2S)-1-azanyl-2-methylbutyl]-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazole-4-carboxylic acid (Ile-Ser) L-isoleucine oxazole-4-carboxylic acid A protein modification that effectively crosslinks two L-serine residues to form serine oxazole-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0464 2-[(1S)-1-amino-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid 2-[(1S)-1-azanyl-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazole-4-carboxylic acid (Ser-Ser) L-serine oxazole-4-carboxylic acid PSI-MOD MOD:01903 Cross-link 2. L-serine oxazole-4-carboxylic acid MOD:01903 A protein modification that effectively crosslinks two L-serine residues to form serine oxazole-4-carboxylic acid. PubMed:21568297 PubMed:21950656 RESID:AA0574 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 DiffMono: -20.026215 Formula: C 6 H 6 N 2 O 3 MassAvg: 154.13 MassMono: 154.037842 Origin: S, S Source: natural TermSpec: none 2-[(1S)-1-amino-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid 2-[(1S)-1-azanyl-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid CROSSLNK Oxazole-4-carboxylic acid (Ser-Ser) L-serine oxazole-4-carboxylic acid A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazoline-4-carboxylic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0465 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazoline-4-carboxylic acid 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid 2-[(1S)-1-azanyl-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid CROSSLNK 5-methyloxazoline-4-carboxylic acid (Ser-Thr) L-serine 5-methyloxazoline-4-carboxylic acid PSI-MOD MOD:01904 Cross-link 2. L-serine 5-methyloxazoline-4-carboxylic acid MOD:01904 A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazoline-4-carboxylic acid. PubMed:21568297 PubMed:21950656 RESID:AA0575 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 7 H 10 N 2 O 3 MassAvg: 170.17 MassMono: 170.069142 Origin: S, T Source: natural TermSpec: none 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazoline-4-carboxylic acid 2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid 2-[(1S)-1-azanyl-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid CROSSLNK 5-methyloxazoline-4-carboxylic acid (Ser-Thr) L-serine 5-methyloxazoline-4-carboxylic acid A protein modification that effectively converts a source amino acid residue to 5-hydroxy-3-methyl-L-proline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid 5-hydroxy-3-methyl-L-proline 5-hydroxy-3-methylproline 5Hy3MePro MOD_RES 5-hydroxy-3-methylproline (Ile) beta-methyl-delta-hydroxyproline PSI-MOD MOD:01905 5-hydroxy-3-methyl-L-proline MOD:01905 A protein modification that effectively converts a source amino acid residue to 5-hydroxy-3-methyl-L-proline. PubMed:7592021 PubMed:8557573 RESID:AA0473 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 6 H 9 N 1 O 2 MassAvg: 127.14 MassMono: 127.063329 Origin: X Source: natural TermSpec: none (2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid 5-hydroxy-3-methyl-L-proline 5-hydroxy-3-methylproline 5Hy3MePro MOD_RES 5-hydroxy-3-methylproline (Ile) beta-methyl-delta-hydroxyproline A protein modification that effectively converts an L-methionine residue to dehydromethionine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (3S)-3-carboxy-1-methylisothiazolidin-1-ium L-dehydromethionine PSI-MOD MOD:01906 dehydromethionine MOD:01906 A protein modification that effectively converts an L-methionine residue to dehydromethionine. PubMed:18688235 PubMed:19775156 DiffAvg: -1.01 DiffFormula: C 0 H -1 N 0 O 0 S 0 DiffMono: -1.008374 FormalCharge: 1+ Formula: C 5 H 9 N 1 O 1 S 1 MassAvg: 131.19 MassMono: 131.039936 Origin: M Source: artifact TermSpec: N-term (3S)-3-carboxy-1-methylisothiazolidin-1-ium L-dehydromethionine A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to dehydromethionine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (3S)-3-carboxy-1-methylisothiazolidin-1-ium L-dehydromethionine PSI-MOD MOD:01907 This process accounts only for cyclizaation and not protonation. The alternative process (MOD:01906) accounts for both protonation and cyclization. dehydromethionine (from L-methioninium) MOD:01907 A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to dehydromethionine. PubMed:18688235 PubMed:19775156 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.016199 FormalCharge: 1+ Formula: C 5 H 9 N 1 O 1 S 1 MassAvg: 131.19 MassMono: 131.039936 Origin: MOD:001464 Source: artifact TermSpec: N-term (3S)-3-carboxy-1-methylisothiazolidin-1-ium L-dehydromethionine A protein modification that effectively converts a residue to the 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: alpha-amino-[(4-sulfophenyl)carbamothioyl] residue PSI-MOD 4-sulfophenyl isothiocyanate SPITC MOD:01908 4-sulfophenyl isothiocyanate alpha-amino derivatized residue MOD:01908 A protein modification that effectively converts a residue to the 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue. PubMed:14689565 PubMed:14745769 PubMed:15549660 PubMed:16526082 Unimod:261#N-term DiffAvg: 215.24 DiffFormula: C 7 H 5 N 1 O 3 S 2 DiffMono: 214.971085 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:261 alpha-amino-[(4-sulfophenyl)carbamothioyl] residue 4-sulfophenyl isothiocyanate SPITC A protein modification that effectively converts a residue to the 6x(13)C labeled 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD 4-sulfophenyl isothiocyanate (Heavy C13) SPITC:13C(6) MOD:01909 6x(13)C labeled 4-sulfophenyl isothiocyanate alpha-amino derivatized residue MOD:01909 A protein modification that effectively converts a residue to the 6x(13)C labeled 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue. PubMed:11467524 PubMed:16526082 Unimod:464#N-term DiffAvg: 220.99 DiffFormula: (12)C 1 (13)C 6 H 5 N 1 O 3 S 2 DiffMono: 220.991214 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:464 4-sulfophenyl isothiocyanate (Heavy C13) SPITC:13C(6) A protein modification that effectively substitutes one hydrogen atom of a residue with one fluorine atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: F1Res PSI-MOD MOD:01910 monofluorinated residue MOD:01910 A protein modification that effectively substitutes one hydrogen atom of a residue with one fluorine atom. Unimod:127 DiffAvg: 17.99 DiffFormula: C 0 F 1 H -1 N 0 O 0 DiffMono: 17.990578 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:127 F1Res A protein modification that effectively substitutes one hydrogen atom of a residue with one chlorine atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Cl1Res PSI-MOD MOD:01911 monochlorinated residue MOD:01911 A protein modification that effectively substitutes one hydrogen atom of a residue with one chlorine atom. Unimod:936 DiffAvg: 34.44 DiffFormula: C 0 Cl 1 H -1 N 0 O 0 DiffMono: 33.961028 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:936 Cl1Res A protein modification that effectively substitutes one hydrogen atom of a residue with one bromine atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: Br1Res PSI-MOD MOD:01912 monobrominated residue MOD:01912 A protein modification that effectively substitutes one hydrogen atom of a residue with one bromine atom. Unimod:340 DiffAvg: 78.90 DiffFormula: Br 1 C 0 H -1 N 0 O 0 DiffMono: 77.910512 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Unimod: Unimod:340 Br1Res A protein modification that effectively substitutes one hydrogen atom of an L-tryptophan residue with one chlorine atom. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Cl1Trp PSI-MOD MOD:01913 monochlorinated L-tryptophan MOD:01913 A protein modification that effectively substitutes one hydrogen atom of an L-tryptophan residue with one chlorine atom. PubMed:18688235 DiffAvg: 34.44 DiffFormula: C 0 Cl 1 H -1 N 0 O 0 DiffMono: 33.961028 Formula: C 11 Cl 1 H 9 N 2 O 1 MassAvg: 220.66 MassMono: 220.040341 Origin: W Source: artifact TermSpec: none Cl1Trp A protein modification that effectively converts a 5-hydroxy-L-lysine residue to O5-galactosyl-L-hydroxylysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0556 CARBOHYD O-linked (Gal) hydroxylysine OGal5HyLys PSI-MOD Galactosyl hydroxylysine MOD:01914 Secondary to RESID:AA0028. This intermediate is rarely observed [JSG]. O5-galactosyl-L-hydroxylysine MOD:01914 A protein modification that effectively converts a 5-hydroxy-L-lysine residue to O5-galactosyl-L-hydroxylysine. PMID:743239 PubMed:17516569 Unimod:907 DiffAvg: 162.14 DiffFormula: C 6 H 10 O 5 DiffMono: 162.052823 Formula: C 16 H 22 N 2 O 7 MassAvg: 354.36 MassMono: 354.142701 Origin: MOD:00037 Source: natural TermSpec: none Unimod: Unimod:907 CARBOHYD O-linked (Gal) hydroxylysine OGal5HyLys Galactosyl hydroxylysine A protein modification that effectively converts an L-alanine residue to N-formyl-L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-(formylamino)propanoic acid 2-formamidopropanoic acid 2-formamidopropionic acid N-formyl-L-alanine PSI-MOD MOD:01915 N-formyl-L-alanine MOD:01915 A protein modification that effectively converts an L-alanine residue to N-formyl-L-alanine. PubMed:9334739 RESID:AA0576 DiffAvg: 28.01 DiffFormula: C 1 H 0 N 0 O 1 DiffMono: 27.994915 Formula: C 4 H 6 N 1 O 2 MassAvg: 100.10 MassMono: 100.039853 Origin: A Source: hypothetical TermSpec: N-term (2S)-2-(formylamino)propanoic acid 2-formamidopropanoic acid 2-formamidopropionic acid N-formyl-L-alanine A protein modification that effectively converts an L-tyrosine residue to O4'-(N-acetylamino)galactosyl-L-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0570 (2S)-2-amino-3-(D-2-acetamido-2-deoxygalactopyranosyloxy)phenylpropanoic acid CARBOHYD O-linked (GalNAc) tyrosine O4'-(N-acetylamino)galactosyl-L-tyrosine O4'-(N-acetylgalactosaminyl)tyrosine O4'-glycosyl-L-tyrosine mucin type O-glycosyltyrosine PSI-MOD MOD:01916 O4'-(N-acetylamino)galactosyl-L-tyrosine MOD:01916 A protein modification that effectively converts an L-tyrosine residue to O4'-(N-acetylamino)galactosyl-L-tyrosine. PubMed:21712440 PubMed:21983924 RESID:AA0577 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 17 H 22 N 2 O 7 MassAvg: 366.37 MassMono: 366.142701 Origin: Y Source: natural TermSpec: none (2S)-2-amino-3-(D-2-acetamido-2-deoxygalactopyranosyloxy)phenylpropanoic acid CARBOHYD O-linked (GalNAc) tyrosine O4'-(N-acetylamino)galactosyl-L-tyrosine O4'-(N-acetylgalactosaminyl)tyrosine O4'-glycosyl-L-tyrosine mucin type O-glycosyltyrosine A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of water. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0486 (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) N(epsilon)-(beta-aspartyl)lysine N6-(L-isoaspartyl)-L-lysine XLNK-4Asp-N6Lys(Asp) beta-(N6-lysyl)aspartyl acid isoaspartyl N6-lysine PSI-MOD MOD:01917 Cross-link 2. N6-(L-isoaspartyl)-L-lysine (Asp) MOD:01917 A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of water. ChEBI:21862 PubMed:11000116 PubMed:15044436 PubMed:18063798 PubMed:6503713 RESID:AA0294#ASP DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 10 H 15 N 3 O 3 MassAvg: 225.25 MassMono: 225.111341 Origin: D, K Source: natural TermSpec: none (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) N(epsilon)-(beta-aspartyl)lysine N6-(L-isoaspartyl)-L-lysine XLNK-4Asp-N6Lys(Asp) beta-(N6-lysyl)aspartyl acid isoaspartyl N6-lysine A protein modification that effectively converts an L-lysine residue to (2S,5S)-5-hydroxylysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0472 (2S,5S)-2,6-diamino-5-hydroxyhexanoic acid (2S,5S)-5-hydroxylysine 2,6-bisazanyl-5-hydroxyhexanoic acid 2,6-diamino-2,3,4,6-tetradeoxyhexonic acid L-allo-delta-hydroxylysine L-threo-delta-hydroxylysine MOD_RES (5S)-5-hydroxylysine alpha,epsilon-diamino-delta-hydroxycaproic acid PSI-MOD MOD:01918 (2S,5S)-5-hydroxylysine MOD:01918 A protein modification that effectively converts an L-lysine residue to (2S,5S)-5-hydroxylysine. PubMed:19574390 PubMed:22238144 RESID:AA0578 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 12 N 2 O 2 MassAvg: 144.17 MassMono: 144.089878 Origin: K Source: natural TermSpec: none (2S,5S)-2,6-diamino-5-hydroxyhexanoic acid (2S,5S)-5-hydroxylysine 2,6-bisazanyl-5-hydroxyhexanoic acid 2,6-diamino-2,3,4,6-tetradeoxyhexonic acid L-allo-delta-hydroxylysine L-threo-delta-hydroxylysine MOD_RES (5S)-5-hydroxylysine alpha,epsilon-diamino-delta-hydroxycaproic acid A protein modification that effectively converts an L-aspartic acid residue to (2S,3S)-3-hydroxyaspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0473 (2S,3S)-2-amino-3-hydroxybutanedioic acid (2S,3S)-3-hydroxyaspartic acid (3S)-3-hydroxy-L-aspartic acid 2-amino-3-hydroxysuccinic acid 2-azanyl-3-hydroxybutanedioic acid 3-hydroxyaspartic acid L-threo-3-hydroxyaspartic acid L-threo-beta-hydroxyaspartic acid MOD_RES (3S)-3-hydroxyaspartate PSI-MOD MOD:01919 (2S,3S)-3-hydroxyaspartic acid MOD:01919 A protein modification that effectively converts an L-aspartic acid residue to (2S,3S)-3-hydroxyaspartic acid. ChEBI:10696 ChEBI:138111 PubMed:21177872 RESID:AA0579 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 4 H 5 N 1 O 4 MassAvg: 131.09 MassMono: 131.021858 Origin: D Source: natural TermSpec: none (2S,3S)-2-amino-3-hydroxybutanedioic acid (2S,3S)-3-hydroxyaspartic acid (3S)-3-hydroxy-L-aspartic acid 2-amino-3-hydroxysuccinic acid 2-azanyl-3-hydroxybutanedioic acid 3-hydroxyaspartic acid L-threo-3-hydroxyaspartic acid L-threo-beta-hydroxyaspartic acid MOD_RES (3S)-3-hydroxyaspartate A protein modification that effectively converts an L-histidine residue to 3-hydroxy-L-histidine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0477 (2S)-2-amino-3-hydroxy-3-(1H-imidazol-4-yl)propanoic acid 3-hydroxy-L-histidine MOD_RES (3S)-3-hydroxyhistidine PSI-MOD MOD:01920 3-hydroxy-L-histidine MOD:01920 A protein modification that effectively converts an L-histidine residue to 3-hydroxy-L-histidine. ChEBI:138021 PubMed:21251231 RESID:AA0580 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 7 N 3 O 2 MassAvg: 153.14 MassMono: 153.053826 Origin: H Source: natural TermSpec: none (2S)-2-amino-3-hydroxy-3-(1H-imidazol-4-yl)propanoic acid 3-hydroxy-L-histidine MOD_RES (3S)-3-hydroxyhistidine A protein modification that effectively converts an L-aspartic acid residue to D-aspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-aminobutanedioic acid 2-azanylbutanedioic acid D-aspartic acid aminosuccinic acid PSI-MOD MOD:01921 D-aspartic acid (Asp) MOD:01921 A protein modification that effectively converts an L-aspartic acid residue to D-aspartic acid. ChEBI:48094 PubMed:9384562 RESID:AA0190#ASP DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Formula: C 4 H 5 N 1 O 3 MassAvg: 115.09 MassMono: 115.026943 Origin: D Source: artifactual TermSpec: none (2R)-2-aminobutanedioic acid 2-azanylbutanedioic acid D-aspartic acid aminosuccinic acid A protein modification that effectively converts an L-serine residue to 3-methoxydehydroalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-amino-3-methoxyprop-2-enoic acid 3-methoxydehydroalanine 3-methoxydidehydroalanine PSI-MOD MOD:01922 3-methoxydehydroalanine MOD:01922 A protein modification that effectively converts an L-serine residue to 3-methoxydehydroalanine. PubMed:19745839 RESID:AA0582 DiffAvg: 12.01 DiffFormula: C 1 H 0 N 0 O 0 DiffMono: 12.000000 Formula: C 4 H 5 N 1 O 2 MassAvg: 99.09 MassMono: 99.032028 Origin: S Source: natural TermSpec: none 2-amino-3-methoxyprop-2-enoic acid 3-methoxydehydroalanine 3-methoxydidehydroalanine A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-aspartyl)-L-lysine and the release of water. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-([(2S)-2-amino-3-carboxypropanoyl]amino)hexanoic acid N(epsilon)-(alpha-aspartyl)lysine N6-(L-aspartyl)-L-lysine XLNK-4Asp-N6Lys(Asp) alpha-(N6-lysyl)aspartyl acid aspartyl N6-lysine PSI-MOD MOD:01923 Cross-link 2. N6-(L-aspartyl)-L-lysine MOD:01923 A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-aspartyl)-L-lysine and the release of water. PubMed:15044436 RESID:AA0583 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 10 H 16 N 3 O 4 MassAvg: 242.26 MassMono: 242.114081 Origin: D, K Source: natural TermSpec: C-term (2S)-2-amino-6-([(2S)-2-amino-3-carboxypropanoyl]amino)hexanoic acid N(epsilon)-(alpha-aspartyl)lysine N6-(L-aspartyl)-L-lysine XLNK-4Asp-N6Lys(Asp) alpha-(N6-lysyl)aspartyl acid aspartyl N6-lysine A protein modification that effectively converts an L-cysteine residue to S-octanoyl-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-3-(octanoylsulfanyl)propanoic acid 2-amino-3-(octanoylthio)propanoic acid ACT_SITE Acyl-thioester intermediate S-octanoyl-L-cysteine cysteine octanoate thioester PSI-MOD MOD:01924 S-octanoyl-L-cysteine MOD:01924 A protein modification that effectively converts an L-cysteine residue to S-octanoyl-L-cysteine. PubMed:12591875 PubMed:16342964 RESID:AA0584 DiffAvg: 126.20 DiffFormula: C 8 H 14 N 0 O 1 S 0 DiffMono: 126.104465 Formula: C 11 H 19 N 1 O 2 S 1 MassAvg: 229.34 MassMono: 229.113650 Origin: C Source: natural TermSpec: none (2S)-2-amino-3-(octanoylsulfanyl)propanoic acid 2-amino-3-(octanoylthio)propanoic acid ACT_SITE Acyl-thioester intermediate S-octanoyl-L-cysteine cysteine octanoate thioester A protein modification that effectively converts an L-lysine residue to (2S,5R)-5-hydroxylysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0471 (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid (2S,5R)-5-hydroxylysine 2,6-bisazanyl-5-hydroxyhexanoic acid 2,6-diamino-2,3,4,6-tetradeoxyhexonic acid 5-hydroxylated L-lysine 5HyLys L-erythro-delta-hydroxylysine MOD_RES (2S,5R)-5-hydroxylysine alpha,epsilon-diamino-delta-hydroxycaproic acid PSI-MOD MOD:01925 (2S,5R)-5-hydroxylysine MOD:01925 A protein modification that effectively converts an L-lysine residue to (2S,5R)-5-hydroxylysine. ChEBI:18040 PubMed:13375629 PubMed:15504407 PubMed:16101297 PubMed:2857489 RESID:AA0028 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 12 N 2 O 2 MassAvg: 144.17 MassMono: 144.089878 Origin: K Source: natural TermSpec: none (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid (2S,5R)-5-hydroxylysine 2,6-bisazanyl-5-hydroxyhexanoic acid 2,6-diamino-2,3,4,6-tetradeoxyhexonic acid 5-hydroxylated L-lysine 5HyLys L-erythro-delta-hydroxylysine MOD_RES (2S,5R)-5-hydroxylysine alpha,epsilon-diamino-delta-hydroxycaproic acid A protein modification that effectively converts an L-aspartic acid residue to one of the diastereomeric 3-hydroxy-L-aspartic acid residues. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: (2S)-2-amino-3-hydroxybutanedioic acid (2S)-3-hydroxyaspartic acid 3HyAsp erythro-beta-hydroxylated L-aspartic acid hydroxylationd monohydroxylated aspartic acid PSI-MOD Oxidation MOD:01926 3-hydroxy-L-aspartic acid MOD:01926 A protein modification that effectively converts an L-aspartic acid residue to one of the diastereomeric 3-hydroxy-L-aspartic acid residues. OMSSA:59 Unimod:35#D DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 4 H 5 N 1 O 4 MassAvg: 131.09 MassMono: 131.021858 Origin: D Source: natural TermSpec: none Unimod: Unimod:35 (2S)-2-amino-3-hydroxybutanedioic acid (2S)-3-hydroxyaspartic acid 3HyAsp erythro-beta-hydroxylated L-aspartic acid hydroxylationd monohydroxylated aspartic acid Oxidation A protein modification that effectively converts an L-tyrosine residue to O4'-glycosyltyrosine. Origin: Source: TermSpec: OGlycoTyr PSI-MOD MOD:01927 O-glycosyl-L-tyrosine MOD:01927 A protein modification that effectively converts an L-tyrosine residue to O4'-glycosyltyrosine. PubMed:18688235 Origin: Y Source: natural TermSpec: none OGlycoTyr A protein modification that effectively crosslinks either an L-asparagine residue or an L-aspartic acid residue with a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid 2-amino-N4-(carboxymethyl)-butanediamic acid N-(L-isoaspartyl)-glycine N-beta-aspartylglycine N4-(carboxymethyl)-asparagine XLNK-4Asp-NGly isoaspartyl glycine PSI-MOD MOD:01928 Cross-link 2. N-(L-isoaspartyl)-glycine MOD:01928 A protein modification that effectively crosslinks either an L-asparagine residue or an L-aspartic acid residue with a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine. ChEBI:21479 PubMed:1826288 RESID:AA0126 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 6 H 7 N 2 O 3 MassAvg: 155.13 MassMono: 155.045667 Origin: G Source: natural TermSpec: N-term (2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid 2-amino-N4-(carboxymethyl)-butanediamic acid N-(L-isoaspartyl)-glycine N-beta-aspartylglycine N4-(carboxymethyl)-asparagine XLNK-4Asp-NGly isoaspartyl glycine A protein modification that effectively crosslinks an either an L-asparagine residue or an L-aspartic acid residue with an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) N(epsilon)-(beta-aspartyl)lysine N-(beta-Aspartyl)-Lysine (Crosslink) N6-(L-isoaspartyl)-L-lysine XLNK-4Asp-N6Lys beta-(N6-lysyl)aspartyl acid isoaspartyl N6-lysine PSI-MOD MOD:01929 Cross-link 2. N6-(L-isoaspartyl)-L-lysine MOD:01929 A protein modification that effectively crosslinks an either an L-asparagine residue or an L-aspartic acid residue with an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine. ChEBI:21862 DeltaMass:0 PubMed:11000116 PubMed:6503713 RESID:AA0294 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 10 H 15 N 3 O 3 MassAvg: 225.25 MassMono: 225.111341 Origin: K Source: natural TermSpec: none (2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn) N(epsilon)-(beta-aspartyl)lysine N-(beta-Aspartyl)-Lysine (Crosslink) N6-(L-isoaspartyl)-L-lysine XLNK-4Asp-N6Lys beta-(N6-lysyl)aspartyl acid isoaspartyl N6-lysine A protein modification that effectively converts an L-asparagine residue to D-aspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-aminobutanedioic acid 2-azanylbutanedioic acid D-aspartic acid aminosuccinic acid PSI-MOD MOD:01930 D-aspartic acid (Asn) MOD:01930 A protein modification that effectively converts an L-asparagine residue to D-aspartic acid. ChEBI:48094 PubMed:9384562 RESID:AA0190#ASN DiffAvg: 0.98 DiffFormula: C 0 H -1 N -1 O 1 DiffMono: 0.984016 Formula: C 4 H 5 N 1 O 3 MassAvg: 115.09 MassMono: 115.026943 Origin: N Source: artifactual TermSpec: none (2R)-2-aminobutanedioic acid 2-azanylbutanedioic acid D-aspartic acid aminosuccinic acid A protein modification that effectively converts an L-lysine residue to N6-phospho-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-(phosphonoamino)hexanoic acid (2S)-2-azanyl-6-(phosphonoamino)hexanoic acid 6-phospholysine N(6)-phosphonolysine N(epsilon)-phospholysine N(epsilon)-phosphonolysine N(epsilon)-phosphonyllysine N(epsilon)-phosphoryllysine N6-phospho-L-lysine PSI-MOD MOD:01931 N6-phospho-L-lysine MOD:01931 A protein modification that effectively converts an L-lysine residue to N6-phospho-L-lysine. PubMed:20144148 RESID:AA0585 DiffAvg: 79.98 DiffFormula: C 0 H 1 N 0 O 3 P 1 DiffMono: 79.966331 Formula: C 6 H 13 N 2 O 4 P 1 MassAvg: 208.15 MassMono: 208.061294 Origin: K Source: hypothetical TermSpec: none (2S)-2-amino-6-(phosphonoamino)hexanoic acid (2S)-2-azanyl-6-(phosphonoamino)hexanoic acid 6-phospholysine N(6)-phosphonolysine N(epsilon)-phospholysine N(epsilon)-phosphonolysine N(epsilon)-phosphonyllysine N(epsilon)-phosphoryllysine N6-phospho-L-lysine A protein modification that effectively cross-links two lysine residues with a carbon-nitrogen bond to form L-lysinonorleucine.. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-([(5S)-5-amino-5-carboxypentyl]amino)hexanoic acid (2S,2'S)-6,6'-iminobis(2-aminohexanoic acid) 6-(N6-L-lysino)-L-norleucine L-lysinonorleucine N6-[(5S)-5-amino-5-carboxypentyl]-L-lysine lysinonorleucine lysinorleucine [misspelling] lysylnorleucine PSI-MOD MOD:01932 Cross-link 2. L-lysinonorleucine MOD:01932 A protein modification that effectively cross-links two lysine residues with a carbon-nitrogen bond to form L-lysinonorleucine.. PubMed:5117030 PubMed:5817620 PubMed:5879466 PubMed:6030254 RESID:AA0586 DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 12 H 21 N 3 O 2 MassAvg: 239.32 MassMono: 239.163377 Origin: K, K Source: natural TermSpec: none (2S)-2-amino-6-([(5S)-5-amino-5-carboxypentyl]amino)hexanoic acid (2S,2'S)-6,6'-iminobis(2-aminohexanoic acid) 6-(N6-L-lysino)-L-norleucine L-lysinonorleucine N6-[(5S)-5-amino-5-carboxypentyl]-L-lysine lysinonorleucine lysinorleucine [misspelling] lysylnorleucine A protein modification that effectively cross-links four L-lysine residues to form desmosine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium 6-[4-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine desmosine PSI-MOD MOD:01933 Cross-link 4. desmosine MOD:01933 A protein modification that effectively cross-links four L-lysine residues to form desmosine. ChEBI:37629 PubMed:13941623 PubMed:14109938 PubMed:14109939 PubMed:5839176 RESID:AA0587 DiffAvg: -58.15 DiffFormula: C 0 H -16 N -3 O 0 DiffMono: -58.134971 FormalCharge: 1+ Formula: C 24 H 32 N 5 O 4 MassAvg: 454.55 MassMono: 454.244881 Origin: K, K, K, K Source: natural TermSpec: none 4-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium 6-[4-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine desmosine A protein modification that effectively cross-links four L-lysine residues to form isodesmosine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium 6-[2-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine isodesmosine PSI-MOD MOD:01934 Cross-link 4. isodesmosine MOD:01934 A protein modification that effectively cross-links four L-lysine residues to form isodesmosine. ChEBI:37629 PubMed:13941623 PubMed:14109938 PubMed:14109939 PubMed:5839176 RESID:AA0588 DiffAvg: -58.15 DiffFormula: C 0 H -16 N -3 O 0 DiffMono: -58.134971 FormalCharge: 1+ Formula: C 24 H 32 N 5 O 4 MassAvg: 454.55 MassMono: 454.244881 Origin: K, K, K, K Source: natural TermSpec: none 2-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium 6-[2-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine isodesmosine modification from RESID DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0572 (D-glucopyranosyl)oxy-L-lysine CARBOHYD O-linked (Glc) hydroxylysine O-glucosyl-L-hydroxylysine PSI-MOD MOD:01935 O-glucosyl-L-hydroxylysine MOD:01935 modification from RESID PubMed:22045808 RESID:AA0589 DiffAvg: 178.14 DiffFormula: C 6 H 10 N 0 O 6 DiffMono: 178.047738 Formula: C 12 H 22 N 2 O 7 MassAvg: 306.32 MassMono: 306.142701 Origin: K Source: natural TermSpec: none (D-glucopyranosyl)oxy-L-lysine CARBOHYD O-linked (Glc) hydroxylysine O-glucosyl-L-hydroxylysine A protein modification that effectively converts an L-lysine residue to N6-oleoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-([(9Z)-octadec-9-enoyl]amino)hexanoic acid N6-[(9Z)-1-oxo-9-octadecenyl]lysine N6-oleoyl-L-lysine PSI-MOD MOD:01936 N6-oleoyl-L-lysine MOD:01936 A protein modification that effectively converts an L-lysine residue to N6-oleoyl-L-lysine. PubMed:20942504 RESID:AA0590 DiffAvg: 264.45 DiffFormula: C 18 H 32 N 0 O 1 DiffMono: 264.245316 Formula: C 24 H 44 N 2 O 2 MassAvg: 392.63 MassMono: 392.340279 Origin: K Source: natural TermSpec: none (2S)-2-amino-6-([(9Z)-octadec-9-enoyl]amino)hexanoic acid N6-[(9Z)-1-oxo-9-octadecenyl]lysine N6-oleoyl-L-lysine A protein modification that effectively converts an L-methionine residue to N-palmitoyl-L-methionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-(hexadecanoylamino)-4-(methylsulfanyl)butanoic acid 2-(hexadecanamido)-4-(methylsulfanyl)butanoic acid LIPID N-palmitoyl methionine N-(1-oxohexadecyl)methionine N-palmitoyl-L-methionine PSI-MOD MOD:01937 N-palmitoyl-L-methionine MOD:01937 A protein modification that effectively converts an L-methionine residue to N-palmitoyl-L-methionine. PubMed:20942504 RESID:AA0591 DiffAvg: 238.41 DiffFormula: C 16 H 30 N 0 O 1 S 0 DiffMono: 238.229666 Formula: C 21 H 40 N 1 O 2 S 1 MassAvg: 370.62 MassMono: 370.277976 Origin: M Source: natural TermSpec: N-term (2S)-2-(hexadecanoylamino)-4-(methylsulfanyl)butanoic acid 2-(hexadecanamido)-4-(methylsulfanyl)butanoic acid LIPID N-palmitoyl methionine N-(1-oxohexadecyl)methionine N-palmitoyl-L-methionine A protein modification that crosslinks an asparagine and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the release of ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid aspartimide cysteine PSI-MOD MOD:01938 Cross-link 2. 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asn) MOD:01938 A protein modification that crosslinks an asparagine and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the release of ammonia. RESID:AA0592#ASN DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 S 0 DiffMono: -17.026549 Formula: C 7 H 8 N 2 O 3 S 1 MassAvg: 200.21 MassMono: 200.025563 Origin: C, N Source: natural TermSpec: none (2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid aspartimide cysteine A protein modification that crosslinks an aspartic acid and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the loss of a water molecule. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid aspartimide cysteine PSI-MOD MOD:01939 Cross-link 2. 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asp) MOD:01939 A protein modification that crosslinks an aspartic acid and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the loss of a water molecule. RESID:AA0592#ASP DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 7 H 8 N 2 O 3 S 1 MassAvg: 200.21 MassMono: 200.025563 Origin: C, D Source: natural TermSpec: none (2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid aspartimide cysteine A protein modification that crosslinks an asparagine and the following glutamic acid residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the release of ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid 2-(2-aminosuccinimidyl)pentanedioic acid aspartimide glutamic acid PSI-MOD MOD:01940 Cross-link 2. 2-(2-aminosuccinimidyl)pentanedioic acid (Asn) MOD:01940 A protein modification that crosslinks an asparagine and the following glutamic acid residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the release of ammonia. RESID:AA0593#ASN DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 9 H 10 N 2 O 5 MassAvg: 226.19 MassMono: 226.058971 Origin: E, N Source: natural TermSpec: none (4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid 2-(2-aminosuccinimidyl)pentanedioic acid aspartimide glutamic acid A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the loss of a water molecule. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid 2-(2-aminosuccinimidyl)pentanedioic acid aspartimide glutamic acid PSI-MOD MOD:01941 Cross-link 2. 2-(2-aminosuccinimidyl)pentanedioic acid (Asp) MOD:01941 A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the loss of a water molecule. RESID:AA0593#ASP DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 9 H 10 N 2 O 5 MassAvg: 226.19 MassMono: 226.058971 Origin: D, E Source: natural TermSpec: none (4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid 2-(2-aminosuccinimidyl)pentanedioic acid aspartimide glutamic acid A protein modification that effectively converts a source amino acid residue to D-aspartic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-aminobutanedioic acid 2-azanylbutanedioic acid D-aspartic acid aminosuccinic acid PSI-MOD MOD:01942 D-aspartic acid MOD:01942 A protein modification that effectively converts a source amino acid residue to D-aspartic acid. ChEBI:48094 PubMed:9384562 RESID:AA0190 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 4 H 5 N 1 O 3 MassAvg: 115.09 MassMono: 115.026943 Origin: X Source: artifactual TermSpec: none (2R)-2-aminobutanedioic acid 2-azanylbutanedioic acid D-aspartic acid aminosuccinic acid A protein modification that crosslinks two adjacent residues by formation of a pyrrolidione ring. PSI-MOD MOD:01943 pyrrolidione ring crosslinked residues MOD:01943 A protein modification that crosslinks two adjacent residues by formation of a pyrrolidione ring. PubMed:18688235 A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01944 Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. 2-aminosuccinimide ring crosslinked residues MOD:01944 A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: none MassAvg: none MassMono: none Origin: X Source: hypothetical TermSpec: none A protein modification that forms (2-aminosuccinimidyl)-3-sulfanylpropanoic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following cysteine residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01945 Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid MOD:01945 A protein modification that forms (2-aminosuccinimidyl)-3-sulfanylpropanoic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following cysteine residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 6 H 6 N 2 O 3 MassAvg: 154.13 MassMono: 154.037842 Origin: C, X Source: hypothetical TermSpec: none A protein modification that forms (2-aminosuccinimidyl)pentanedioicacid by crosslinking either an aspartic acid residue or an asparagine residue with the following glutamic acid residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01946 Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue. 2-(2-aminosuccinimidyl)pentanedioic acid MOD:01946 A protein modification that forms (2-aminosuccinimidyl)pentanedioicacid by crosslinking either an aspartic acid residue or an asparagine residue with the following glutamic acid residue. PubMed:18688235 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 6 H 6 N 2 O 3 MassAvg: 154.13 MassMono: 154.037842 Origin: E, X Source: hypothetical TermSpec: none A protein modification that effectively cross-links an L-threonine residue and an L-aspartic acid residue with an ester bond to form O-(L-isoaspartyl)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid CROSSLNK isoaspartyl threonine ester (Thr-Asp) O(beta)-(beta-aspartyl)threonine O-(L-isoaspartyl)-L-threonine O3-(isoaspartyl)-threonine PSI-MOD MOD:01947 Cross-link 2. O-(L-isoaspartyl)-L-threonine (cross-link) MOD:01947 A protein modification that effectively cross-links an L-threonine residue and an L-aspartic acid residue with an ester bond to form O-(L-isoaspartyl)-L-threonine. PubMed:17157318 PubMed:8706862 RESID:AA0525#TDX DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 DiffMono: -18.010565 Formula: C 8 H 10 N 2 O 4 MassAvg: 198.18 MassMono: 198.064057 Origin: D, T Source: natural TermSpec: none (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid CROSSLNK isoaspartyl threonine ester (Thr-Asp) O(beta)-(beta-aspartyl)threonine O-(L-isoaspartyl)-L-threonine O3-(isoaspartyl)-threonine A protein modification that effectively cross-links an L-cysteine residue and two L-serine residues by a thioether bond and a carbon-carbon bond to form labionin. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S,4S)-2,4-diamino-2-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)methyl]pentanedioic acid (2S,4S,8R)-2,4,8-triamino-4-carboxy-6-thianonanedioic acid (2S,4S,8R)-labionin labionin PSI-MOD MOD:01948 Cross-link 3. labionin MOD:01948 A protein modification that effectively cross-links an L-cysteine residue and two L-serine residues by a thioether bond and a carbon-carbon bond to form labionin. PubMed:20082397 RESID:AA0594 DiffAvg: -36.03 DiffFormula: C 0 H -4 N 0 O -2 S 0 DiffMono: -36.021129 Formula: C 9 H 11 N 3 O 3 S 1 MassAvg: 241.26 MassMono: 241.052112 Origin: C, S, S Source: natural TermSpec: none (2S,4S)-2,4-diamino-2-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)methyl]pentanedioic acid (2S,4S,8R)-2,4,8-triamino-4-carboxy-6-thianonanedioic acid (2S,4S,8R)-labionin labionin A protein modification that effectively cross-links a phenylalanine and two tyrosine residues to form coelenterazine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 8-benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one Oplophorus luciferin coelenterazine PSI-MOD MOD:01949 Cross-link 3. coelenterazine MOD:01949 A protein modification that effectively cross-links a phenylalanine and two tyrosine residues to form coelenterazine. ChEBI:2311 PubMed:10830969 PubMed:11572972 PubMed:19833098 RESID:AA0595 DiffAvg: -50.06 DiffFormula: C -1 H -6 N 0 O -2 DiffMono: -50.036779 Formula: C 26 H 21 N 3 O 3 MassAvg: 423.47 MassMono: 423.158292 Origin: F, Y, Y Source: hypothetical TermSpec: N-term 8-benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one Oplophorus luciferin coelenterazine A protein modification that effectively converts an L-glutamine residue to L-isoglutamyl histamine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0488 (2S)-2-amino-5-([2-(1H-imidazol-5-yl)ethyl]amino)-5-oxopentanoic acid (gamma-glutamyl)histamine L-isoglutamyl histamine PSI-MOD MOD:01950 L-isoglutamyl histamine MOD:01950 A protein modification that effectively converts an L-glutamine residue to L-isoglutamyl histamine. PubMed:23022564 RESID:AA0596 DiffAvg: 94.12 DiffFormula: C 5 H 6 N 2 O 0 DiffMono: 94.053098 Formula: C 10 H 14 N 4 O 2 MassAvg: 222.25 MassMono: 222.111676 Origin: Q Source: natural TermSpec: none (2S)-2-amino-5-([2-(1H-imidazol-5-yl)ethyl]amino)-5-oxopentanoic acid (gamma-glutamyl)histamine L-isoglutamyl histamine A protein modification that effectively crosslinks an L-glutamine residue and an L-serine residue by an ester bond and releasing ammonia to form O-(L-isoglutamyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid O(beta)-(gamma-glutamyl)serine O-(L-isoglutamyl)-L-serine O3-(isoglutamyl)-serine PSI-MOD MOD:01951 Cross-link 2. O-(L-isoglutamyl)-L-serine (Gln-Ser) MOD:01951 A protein modification that effectively crosslinks an L-glutamine residue and an L-serine residue by an ester bond and releasing ammonia to form O-(L-isoglutamyl)-L-serine. PubMed:17051152 RESID:AA0597#QSX DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 8 H 10 N 2 O 4 MassAvg: 198.18 MassMono: 198.064057 Origin: Q, S Source: natural TermSpec: none (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid O(beta)-(gamma-glutamyl)serine O-(L-isoglutamyl)-L-serine O3-(isoglutamyl)-serine A protein modification that effectively cross-links an L-threonine residue and an L-glutamine residue with an ester bond releasing ammonia to form O-(L-isoglutamyl)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid 5-(threon-O3-yl)glutamate O(beta)-(gamma-glutamyl)threonine O-(L-isoglutamyl)-L-threonine O3-(isoglutamyl)threonine PSI-MOD MOD:01952 Cross-link 2. O-(L-isoglutamyl)-L-threonine (Gln-Thr) MOD:01952 A protein modification that effectively cross-links an L-threonine residue and an L-glutamine residue with an ester bond releasing ammonia to form O-(L-isoglutamyl)-L-threonine. PubMed:17051152 RESID:AA0536#TQX DiffAvg: -17.03 DiffFormula: C 0 H -3 N -1 O 0 DiffMono: -17.026549 Formula: C 9 H 12 N 2 O 4 MassAvg: 212.20 MassMono: 212.079707 Origin: Q, T Source: natural TermSpec: none (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid 5-(threon-O3-yl)glutamate O(beta)-(gamma-glutamyl)threonine O-(L-isoglutamyl)-L-threonine O3-(isoglutamyl)threonine A protein modification that effectively converts four L-cysteine residues and a four-iron cluster to tetrakis-L-cysteinyl tetrairon octanitrosyl. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01953 Cross-link 4. tetrakis-L-cysteinyl tetrairon octanitrosyl MOD:01953 A protein modification that effectively converts four L-cysteine residues and a four-iron cluster to tetrakis-L-cysteinyl tetrairon octanitrosyl. PubMed:21182249 RESID:AA0599 DiffAvg: 459.40 DiffFormula: C 0 Fe 4 H -4 N 8 O 8 S 0 DiffMono: 459.692359 Formula: C 12 Fe 4 H 16 N 12 O 12 S 4 MassAvg: 871.95 MassMono: 871.729098 Origin: C, C, C, C Source: hypothetical TermSpec: none A protein modification that effectively converts an L-selenocysteine residue to dehydroalanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dha anhydroserine dehydroalanine PSI-MOD MOD:01954 dehydroalanine (Sec) MOD:01954 A protein modification that effectively converts an L-selenocysteine residue to dehydroalanine. ChEBI:17123 PubMed:10220322 PubMed:12781460 PubMed:1547888 PubMed:1815586 PubMed:20805503 PubMed:21420488 PubMed:22031445 PubMed:2914619 PubMed:7947813 PubMed:8239649 RESID:AA0181 DiffAvg: -80.99 DiffFormula: C 0 H -2 N 0 O 0 Se -1 DiffMono: -81.932171 Formula: C 3 H 3 N 1 O 1 MassAvg: 69.06 MassMono: 69.021464 Origin: U Source: natural TermSpec: none 2,3-didehydroalanine 2-aminoacrylic acid 2-aminopropenoic acid 4-methylidene-imidazole-5-one (MIO) active site Dha anhydroserine dehydroalanine modification from RESID DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4Mn-Ca-5O cluster L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide mu2-alaninato-1kappaO(1),3kappaO(1')-mu2-aspartato-1kappaO(4),5kappaO(4')-mu2-aspartato-2kappaO(4),3kappaO(4')-mu2-glutamato-3kappaO(5),4kappaO(5')-mu2-glutamato-4kappaO(5),5kappaO(5')-mu-glutamato-2kappaO(5)-mu-histidino-2kappaN(tau)-mu4-oxido-1:2:4:5kappa(4)O-tri-mu3-oxido-1:2:3kappa(3)O;1:3:4kappa(3)O;2:3:4kappa(3)O;mu-oxido-4:5kappa(2)O-calciumtetramanganese photosystem II catalytic cluster PSI-MOD MOD:01955 Cross-link 7. L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide MOD:01955 modification from RESID PubMed:21499260 RESID:AA0600 DiffAvg: 333.78 DiffFormula: C 0 Ca 1 H -6 Mn 4 N 0 O 5 DiffMono: 333.642394 Formula: C 32 Ca 1 H 38 Mn 4 N 9 O 23 MassAvg: 1176.53 MassMono: 1175.922825 Origin: A, D, D, E, E, E, H Source: natural TermSpec: C-term 4Mn-Ca-5O cluster L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide mu2-alaninato-1kappaO(1),3kappaO(1')-mu2-aspartato-1kappaO(4),5kappaO(4')-mu2-aspartato-2kappaO(4),3kappaO(4')-mu2-glutamato-3kappaO(5),4kappaO(5')-mu2-glutamato-4kappaO(5),5kappaO(5')-mu-glutamato-2kappaO(5)-mu-histidino-2kappaN(tau)-mu4-oxido-1:2:4:5kappa(4)O-tri-mu3-oxido-1:2:3kappa(3)O;1:3:4kappa(3)O;2:3:4kappa(3)O;mu-oxido-4:5kappa(2)O-calciumtetramanganese photosystem II catalytic cluster A protein modification that effectively converts an L-arginine residue to (3R)-3-hydroxy-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0476 (2S,3R)-2-amino-5-[(diaminomethylidene)amino]-3-hydroxypentanoic acid (3R)-3-hydroxy-L-arginine 2-amino-5-(carbamimidamido)-3-hydroxypentanoic acid [tautomer] 2-amino-5-[(aminoiminomethyl)amino]-3-hydroxypentanoic acid [tautomer] 2-amino-5-guanidino-3-hydroxypentanoic acid C(beta)-hydroxyarginine MOD_RES (3R)-3-hydroxyarginine beta-hydroxyarginine PSI-MOD MOD:01956 (3R)-3-hydroxy-L-arginine MOD:01956 A protein modification that effectively converts an L-arginine residue to (3R)-3-hydroxy-L-arginine. PubMed:10094780 PubMed:23103944 PubMed:786730 RESID:AA0601 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 6 H 12 N 4 O 2 MassAvg: 172.19 MassMono: 172.096026 Origin: R Source: natural TermSpec: none (2S,3R)-2-amino-5-[(diaminomethylidene)amino]-3-hydroxypentanoic acid (3R)-3-hydroxy-L-arginine 2-amino-5-(carbamimidamido)-3-hydroxypentanoic acid [tautomer] 2-amino-5-[(aminoiminomethyl)amino]-3-hydroxypentanoic acid [tautomer] 2-amino-5-guanidino-3-hydroxypentanoic acid C(beta)-hydroxyarginine MOD_RES (3R)-3-hydroxyarginine beta-hydroxyarginine A protein modification that effectively converts an L-proline residue to 2-hydroxyproline. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0668 (2R)-2-hydroxypyrrolidine-2-carboxylic acid 2-hydroxyproline 2-oxidanylpyrrolidine-2-carboxylic acid MOD_RES 2-hydroxyproline alpha-hydroxyproline PSI-MOD MOD:01957 2-hydroxyproline MOD:01957 A protein modification that effectively converts an L-proline residue to 2-hydroxyproline. ChEBI:141809 PubMed:23385463 RESID:AA0602 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 DiffMono: 15.994915 Formula: C 5 H 7 N 1 O 2 MassAvg: 113.12 MassMono: 113.047678 Origin: P Source: hypothetical TermSpec: none (2R)-2-hydroxypyrrolidine-2-carboxylic acid 2-hydroxyproline 2-oxidanylpyrrolidine-2-carboxylic acid MOD_RES 2-hydroxyproline alpha-hydroxyproline A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bisglutathion-S-yl diiron disulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: bis-L-cysteinyl bisglutathion-S-yl diiron disulfide di-mu-sulfido-bis(cysteinato)-1kappaS,2kappaS-bis(glutathionato)-1kappaS,2kappaS-diiron mitochondrial glutaredoxin 2 dimer iron-sulfur cluster plant glutaredoxin C1 dimer iron-sulfur cluster PSI-MOD MOD:01958 Cross-link 2. bis-L-cysteinyl bisglutathion-S-yl diiron disulfide MOD:01958 A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bisglutathion-S-yl diiron disulfide. PubMed:17121859 RESID:AA0603 DiffAvg: 786.42 DiffFormula: C 20 Fe 2 H 30 N 6 O 12 S 4 DiffMono: 785.950329 Formula: C 26 Fe 2 H 40 N 8 O 14 S 6 MassAvg: 992.70 MassMono: 991.968699 Origin: C, C Source: natural TermSpec: none bis-L-cysteinyl bisglutathion-S-yl diiron disulfide di-mu-sulfido-bis(cysteinato)-1kappaS,2kappaS-bis(glutathionato)-1kappaS,2kappaS-diiron mitochondrial glutaredoxin 2 dimer iron-sulfur cluster plant glutaredoxin C1 dimer iron-sulfur cluster A protein modification that effectively converts three L-cysteine residues, an L-glutamic acid and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamato tetrairon tetrasulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: tris-L-cysteinyl L-glutamato tetrairon tetrasulfide tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutamato-4kappaO(5),4kappaO(5')-tetrairon PSI-MOD MOD:01959 Cross-link 4. tris-L-cysteinyl L-glutamato tetrairon tetrasulfide MOD:01959 A protein modification that effectively converts three L-cysteine residues, an L-glutamic acid and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamato tetrairon tetrasulfide. PubMed:21167158 RESID:AA0604 DiffAvg: 347.59 DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono: 347.596734 Formula: C 14 Fe 4 H 18 N 4 O 6 S 7 MassAvg: 786.12 MassMono: 785.666881 Origin: C, C, C, E Source: natural TermSpec: none tris-L-cysteinyl L-glutamato tetrairon tetrasulfide tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutamato-4kappaO(5),4kappaO(5')-tetrairon A protein modification that effectively converts three L-cysteine residues, an L-glutamine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: METAL Iron-sulfur (4Fe-4S) tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutaminato-4kappaN(5)-tetrairon PSI-MOD MOD:01960 Cross-link 4. tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide MOD:01960 A protein modification that effectively converts three L-cysteine residues, an L-glutamine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide. PubMed:11796730 RESID:AA0605 DiffAvg: 347.59 DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4 DiffMono: 347.596734 Formula: C 14 Fe 4 H 19 N 5 O 5 S 7 MassAvg: 785.14 MassMono: 784.682866 Origin: C, C, C, Q Source: natural TermSpec: none METAL Iron-sulfur (4Fe-4S) tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutaminato-4kappaN(5)-tetrairon OBSOLETE because redundant and identical to MOD:01785. Remap to MOD:01785. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid 5-(threon-O3-yl)glutamate O(beta)-(gamma-glutamyl)threonine O-(L-isoglutamyl)-L-threonine O3-(isoglutamyl)threonine PSI-MOD MOD:01961 O-(L-isoglutamyl)-L-threonine (THR) true MOD:01961 OBSOLETE because redundant and identical to MOD:01785. Remap to MOD:01785. PubMed:16618936 PubMed:17051152 PubMed:17687277 PubMed:18555071 RESID:AA0536#THR DiffAvg: 129.12 DiffFormula: C 5 H 7 N 1 O 3 DiffMono: 129.042593 Formula: C 9 H 14 N 2 O 5 MassAvg: 230.22 MassMono: 230.090272 Origin: T Remap: MOD:01785 Source: natural TermSpec: none (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid 5-(threon-O3-yl)glutamate O(beta)-(gamma-glutamyl)threonine O-(L-isoglutamyl)-L-threonine O3-(isoglutamyl)threonine A protein modification that effectively converts an L-asparagine residue to N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0506 (2S)-2-amino-4-[(2,4-diacetylamino-2,4,6-trideoxy-beta-D-glucopyranosyl)amino]-4-oxobutanoic acid CARBOHYD N-linked (DATDGlc) asparagine DABA DATDH DiNAcBac N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine N4-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-asparagine N4-[N,N-diacetylbacillosaminyl]asparagine N4-[N2,N4-diacetylbacillosaminyl]asparagine PSI-MOD MOD:01962 N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine MOD:01962 A protein modification that effectively converts an L-asparagine residue to N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine. PubMed:12186869 PubMed:19236052 RESID:AA0606 DiffAvg: 228.25 DiffFormula: C 10 H 16 N 2 O 4 DiffMono: 228.111007 Formula: C 14 H 22 N 4 O 6 MassAvg: 342.35 MassMono: 342.153934 Origin: N Source: natural TermSpec: none (2S)-2-amino-4-[(2,4-diacetylamino-2,4,6-trideoxy-beta-D-glucopyranosyl)amino]-4-oxobutanoic acid CARBOHYD N-linked (DATDGlc) asparagine DABA DATDH DiNAcBac N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine N4-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-asparagine N4-[N,N-diacetylbacillosaminyl]asparagine N4-[N2,N4-diacetylbacillosaminyl]asparagine A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0548 (2S)-2-amino-4-[(2,4-diacetamido-2,4,6-trideoxy-beta-D-glucopyranosyl)oxy]propanoic acid CARBOHYD O-linked (DATDGlc) serine DABA DATDH DiNAcBac O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine O-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-serine O-[N,N-diacetylbacillosaminyl]serine O-[N2,N4-diacetylbacillosaminyl]serine PSI-MOD MOD:01963 O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine MOD:01963 A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine. PubMed:23030644 RESID:AA0607 DiffAvg: 228.25 DiffFormula: C 10 H 16 N 2 O 4 DiffMono: 228.111007 Formula: C 13 H 21 N 3 O 6 MassAvg: 315.33 MassMono: 315.143035 Origin: S Source: natural TermSpec: none (2S)-2-amino-4-[(2,4-diacetamido-2,4,6-trideoxy-beta-D-glucopyranosyl)oxy]propanoic acid CARBOHYD O-linked (DATDGlc) serine DABA DATDH DiNAcBac O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine O-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-serine O-[N,N-diacetylbacillosaminyl]serine O-[N2,N4-diacetylbacillosaminyl]serine A protein modification that effectively converts an L-serine residue to O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0549 (2S)-2-amino-3-[(2-acetamido-4-glycerylamino-2,4,6-trideoxy-D-glucopyranosyl)oxy]propanoic acid CARBOHYD O-linked (GATDGlc) serine GATDH O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucopyranosyl)-L-serine O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine O-(N2-acetyl-N4-glycerylbacillosaminyl)-L-serine PSI-MOD MOD:01964 O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine MOD:01964 A protein modification that effectively converts an L-serine residue to O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine. PubMed:17804791 RESID:AA0608 DiffAvg: 274.27 DiffFormula: C 11 H 18 N 2 O 6 DiffMono: 274.116486 Formula: C 14 H 23 N 3 O 8 MassAvg: 361.35 MassMono: 361.148515 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-[(2-acetamido-4-glycerylamino-2,4,6-trideoxy-D-glucopyranosyl)oxy]propanoic acid CARBOHYD O-linked (GATDGlc) serine GATDH O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucopyranosyl)-L-serine O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine O-(N2-acetyl-N4-glycerylbacillosaminyl)-L-serine A protein modification that effectively converts an L-lysine residue to 2xC(13),3x(2)H labeled N6-acetyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Acetate labeling reagent (K) (heavy form, +5amu) COFRADIC heavy acetyl 13C2 2H3 PSI-MOD MOD:01965 2xC(13),3x(2)H labeled N6-acetyl-L-lysine MOD:01965 A protein modification that effectively converts an L-lysine residue to 2xC(13),3x(2)H labeled N6-acetyl-L-lysine. PubMed:18688235 DiffAvg: 47.04 DiffFormula: (13)C 2 (1)H -1 (2)H 3 O 1 DiffMono: 47.036105 Formula: (12)C 6 (13)C 2 (1)H 11 (2)H 3 N 2 O 2 MassAvg: 175.13 MassMono: 175.131068 Origin: K Source: artifact TermSpec: none Acetate labeling reagent (K) (heavy form, +5amu) COFRADIC heavy acetyl 13C2 2H3 OBSOLETE because redundant and identical to MOD:00720. Remap to MOD:00720. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Remap: Source: TermSpec: (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid L-methionine (R)-S-oxide L-methionine (R)-sulfoxide MOD_RES Methionine (R)-sulfoxide PSI-MOD MOD:01966 L-methionine (R)-sulfoxide true MOD:01966 OBSOLETE because redundant and identical to MOD:00720. Remap to MOD:00720. ChEBI:45764 PubMed:21406390 PubMed:22116028 PubMed:23911929 RESID:AA0581 DiffAvg: 16.00 DiffFormula: C 0 H 0 N 0 O 1 S 0 DiffMono: 15.994915 Formula: C 5 H 9 N 1 O 2 S 1 MassAvg: 147.19 MassMono: 147.035400 Origin: M Remap: MOD:00720 Source: natural TermSpec: none (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid L-methionine (R)-S-oxide L-methionine (R)-sulfoxide MOD_RES Methionine (R)-sulfoxide A protein modification that effectively converts an L-arginine residue to omega-N-(N-acetylamino)glucosyl-L-arginine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0518 (2S)-2-amino-5-[(amino[(2-N-acetylamino-2-deoxy-D-glucopyranosyl)amino]methylidene)amino]pentanoic acid CARBOHYD N-linked (GlcNAc) arginine N(omega)-(2-N-acetylaminoglucosyl)arginine N(omega)-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine N(omega)-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine NG-(2-N-acetylaminoglucosyl)arginine NG-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine NG-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine omega-N-(2-N-acetylaminoglucosyl)arginine omega-N-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine omega-N-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine omega-N-(N-acetylamino)glucosyl-L-arginine PSI-MOD MOD:01967 omega-N-(N-acetylamino)glucosyl-L-arginine MOD:01967 A protein modification that effectively converts an L-arginine residue to omega-N-(N-acetylamino)glucosyl-L-arginine. PubMed:23955153 RESID:AA0609 DiffAvg: 203.19 DiffFormula: C 8 H 13 N 1 O 5 DiffMono: 203.079373 Formula: C 14 H 25 N 5 O 6 MassAvg: 359.38 MassMono: 359.180484 Origin: R Source: natural TermSpec: none (2S)-2-amino-5-[(amino[(2-N-acetylamino-2-deoxy-D-glucopyranosyl)amino]methylidene)amino]pentanoic acid CARBOHYD N-linked (GlcNAc) arginine N(omega)-(2-N-acetylaminoglucosyl)arginine N(omega)-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine N(omega)-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine NG-(2-N-acetylaminoglucosyl)arginine NG-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine NG-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine omega-N-(2-N-acetylaminoglucosyl)arginine omega-N-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine omega-N-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine omega-N-(N-acetylamino)glucosyl-L-arginine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2R,3R,2'R)-3-methyllanthionine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid (2R,3R,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid (2R,3R,2'R)-3-methyllanthionine (2R,3R,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid (2R,3R,6R)-3-methyllanthionine 2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid 3-methyl-L,L-lanthionine cysteine-3-L-butyrine thioether PSI-MOD MOD:01968 Cross-link 2. (2R,3R,2'R)-3-methyllanthionine MOD:01968 A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2R,3R,2'R)-3-methyllanthionine. PubMed:23314913 RESID:AA0610 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 7 H 10 N 2 O 2 S 1 MassAvg: 186.23 MassMono: 186.046299 Origin: C, T Source: natural TermSpec: none (2R,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid (2R,3R,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid (2R,3R,2'R)-3-methyllanthionine (2R,3R,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid (2R,3R,6R)-3-methyllanthionine 2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid 3-methyl-L,L-lanthionine cysteine-3-L-butyrine thioether A protein modification that effectively converts an L-cysteine residue to S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-([(2R)-1-([2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-oxoethyl]amino)-1-oxo-3-sulfanylpropan-2-yl]amino)-5-oxopentanoic acid ACT_SITE S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine intermediate S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine S-(glutathion-1-yl)-L-cysteine PSI-MOD MOD:01969 S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine MOD:01969 A protein modification that effectively converts an L-cysteine residue to S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine. PubMed:9398217 RESID:AA0611 DiffAvg: 289.31 DiffFormula: C 10 H 15 N 3 O 5 S 1 DiffMono: 289.073242 Formula: C 13 H 20 N 4 O 6 S 2 MassAvg: 392.44 MassMono: 392.082426 Origin: C Source: natural TermSpec: none (2S)-2-amino-5-([(2R)-1-([2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-oxoethyl]amino)-1-oxo-3-sulfanylpropan-2-yl]amino)-5-oxopentanoic acid ACT_SITE S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine intermediate S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine S-(glutathion-1-yl)-L-cysteine A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl glutamic acid, forming an isopeptide bond with a free glutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0479 (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanedioic acid (2S)-2-[(4S)-4-amino-4-carboxybutanamido]pentanedioic acid 2-([4-azanyl-4-carboxybutanoyl]azanyl)pentanedioic acid 5-glutamyl glutamic acid MOD_RES 5-glutamyl glutamate N alpha -(gamma-Glutamyl)-Glu N-(gamma-L-glutamyl)-L-glutamic acid gamma-glutamylglutamate isoglutamyl glutamic acid isoglutamyl monoglutamic acid PSI-MOD Glu monoglutamyl MOD:01970 5-glutamyl glutamic acid MOD:01970 A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl glutamic acid, forming an isopeptide bond with a free glutamic acid. PubMed:10747868 PubMed:15525938 PubMed:1680872 PubMed:23434852 RESID:AA0612 Unimod:450 DiffAvg: 129.12 DiffFormula: C 5 H 7 N 1 O 3 DiffMono: 129.042593 Formula: C 10 H 14 N 2 O 6 MassAvg: 258.23 MassMono: 258.085186 Origin: E Source: natural TermSpec: none Unimod: Unimod:450 (2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanedioic acid (2S)-2-[(4S)-4-amino-4-carboxybutanamido]pentanedioic acid 2-([4-azanyl-4-carboxybutanoyl]azanyl)pentanedioic acid 5-glutamyl glutamic acid MOD_RES 5-glutamyl glutamate N alpha -(gamma-Glutamyl)-Glu N-(gamma-L-glutamyl)-L-glutamic acid gamma-glutamylglutamate isoglutamyl glutamic acid isoglutamyl monoglutamic acid Glu monoglutamyl A protein modification that effectively converts an L-glutamic acid residue to N2-ornithine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0478 (2S)-5-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanoic acid (2S)-5-amino-2-[(4S)-4-amino-4-carboxybutanamido]pentanoic acid 4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-ketovaleric acid 4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-oxopentanoic acid 5-glutamyl N2-ornithine MOD_RES 5-glutamyl N2-ornithine N2-(L-isoglutamyl)-L-ornithine N2-(gamma-glutamyl)ornithine gamma-glutamylornithine PSI-MOD MOD:01971 5-glutamyl N2-ornithine MOD:01971 A protein modification that effectively converts an L-glutamic acid residue to N2-ornithine. ChEBI:136763 PubMed:23434852 RESID:AA0613 DiffAvg: 114.15 DiffFormula: C 5 H 10 N 2 O 1 DiffMono: 114.079313 Formula: C 10 H 17 N 3 O 4 MassAvg: 243.26 MassMono: 243.121906 Origin: E Source: hypothetical TermSpec: none (2S)-5-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanoic acid (2S)-5-amino-2-[(4S)-4-amino-4-carboxybutanamido]pentanoic acid 4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-ketovaleric acid 4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-oxopentanoic acid 5-glutamyl N2-ornithine MOD_RES 5-glutamyl N2-ornithine N2-(L-isoglutamyl)-L-ornithine N2-(gamma-glutamyl)ornithine gamma-glutamylornithine A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl coenzyme A thioester. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-(2-[([3-([(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanoyl]-amino)-propanoyl]-amino)-ethyl]-sulfanyl)-5-oxopentanoic acid (2S)-2-amino-5-([2-(3-[(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanamido]-propanamido)-ethyl]-sulfanyl)-5-oxopentanoic acid 5-glutamyl 4-[(3'-phospho-adenosyl-5'-diphosphoryl)oxy]pantetheine thioester 5-glutamyl coenzyme A thioester 5-glutamyl coenzyme A thioester intermediate PSI-MOD MOD:01972 5-glutamyl coenzyme A thioester MOD:01972 A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl coenzyme A thioester. PubMed:16253988 PubMed:20977214 PubMed:7915164 RESID:AA0614 DiffAvg: 749.52 DiffFormula: C 21 H 34 N 7 O 15 P 3 S 1 DiffMono: 749.104644 Formula: C 26 H 41 N 8 O 18 P 3 S 1 MassAvg: 878.63 MassMono: 878.147237 Origin: E Source: natural TermSpec: none (2S)-2-amino-5-(2-[([3-([(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanoyl]-amino)-propanoyl]-amino)-ethyl]-sulfanyl)-5-oxopentanoic acid (2S)-2-amino-5-([2-(3-[(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanamido]-propanamido)-ethyl]-sulfanyl)-5-oxopentanoic acid 5-glutamyl 4-[(3'-phospho-adenosyl-5'-diphosphoryl)oxy]pantetheine thioester 5-glutamyl coenzyme A thioester 5-glutamyl coenzyme A thioester intermediate A protein modification that effectively converts an L-lysine residue to N6-(3-phosphoglyceryl)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-([(2R)-2-hydroxy-3-(phosphonooxy)propanoyl]amino)hexanoic acid (2S)-2-amino-6-[(2R)-2-hydroxy-3-(phosphonooxy)propanamido]hexanoic acid 3-phosphoglyceryl-lysine N6-(3-phosphoglyceryl)-L-lysine PSI-MOD MOD:01973 N6-(3-phosphoglyceryl)-L-lysine MOD:01973 A protein modification that effectively converts an L-lysine residue to N6-(3-phosphoglyceryl)-L-lysine. PubMed:23908237 RESID:AA0615 DiffAvg: 168.04 DiffFormula: C 3 H 5 N 0 O 6 P 1 DiffMono: 167.982375 Formula: C 9 H 17 N 2 O 7 P 1 MassAvg: 296.22 MassMono: 296.077338 Origin: K Source: natural TermSpec: none (2S)-2-amino-6-([(2R)-2-hydroxy-3-(phosphonooxy)propanoyl]amino)hexanoic acid (2S)-2-amino-6-[(2R)-2-hydroxy-3-(phosphonooxy)propanamido]hexanoic acid 3-phosphoglyceryl-lysine N6-(3-phosphoglyceryl)-L-lysine A protein modification that effectively converts an L-methionine residue to S-methyl-L-methionine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0636 (2S)-2-amino-4-(dimethylsulfonio)butanoate (3S)-(3-amino-3-carboxypropyl)dimethylsulfanium S-methyl-L-methionine S-methylmethionine S-methylmethioninium [(3S)-3-amino-3-carboxypropyl](dimethyl)sulfonium vitamin U PSI-MOD MOD:01974 S-methyl-L-methionine MOD:01974 A protein modification that effectively converts an L-methionine residue to S-methyl-L-methionine. ChEBI:17728 PubMed:23532849 RESID:AA0616 DiffAvg: 15.03 DiffFormula: C 1 H 3 N 0 O 0 S 0 DiffMono: 15.022927 FormalCharge: 1+ Formula: C 6 H 12 N 1 O 1 S 1 MassAvg: 146.23 MassMono: 146.063411 Origin: M Source: natural TermSpec: none (2S)-2-amino-4-(dimethylsulfonio)butanoate (3S)-(3-amino-3-carboxypropyl)dimethylsulfanium S-methyl-L-methionine S-methylmethionine S-methylmethioninium [(3S)-3-amino-3-carboxypropyl](dimethyl)sulfonium vitamin U A protein modification that effectively converts an L-cysteine residue to S-(poly-3-hydroxybutyrate)-L-cysteine. Origin: Source: TermSpec: uniprot.ptm:PTM-0641 (alpha)-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-(omega)-[(3R)-3-hydroxybutanoyl]-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy) MOD_RES S-poly(beta-hydroxybutyryl)lysine S-poly(3-hydroxybutanoate)cysteine S-poly(3-hydroxybutanoic acid)cysteine S-poly(3-hydroxybutyrate)-L-cysteine S-poly(3-hydroxybutyrate)cysteine S-poly(3-hydroxybutyric acid)cysteine S-poly(beta-hydroxybutyrate)cysteine S-poly[(R)-3-hydroxybutyrate]cysteine PSI-MOD MOD:01975 S-poly(3-hydroxybutyrate)-L-cysteine MOD:01975 A protein modification that effectively converts an L-cysteine residue to S-(poly-3-hydroxybutyrate)-L-cysteine. PubMed:19711985 PubMed:9888824 RESID:AA0617 Origin: C Source: natural TermSpec: none (alpha)-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-(omega)-[(3R)-3-hydroxybutanoyl]-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy) MOD_RES S-poly(beta-hydroxybutyryl)lysine S-poly(3-hydroxybutanoate)cysteine S-poly(3-hydroxybutanoic acid)cysteine S-poly(3-hydroxybutyrate)-L-cysteine S-poly(3-hydroxybutyrate)cysteine S-poly(3-hydroxybutyric acid)cysteine S-poly(beta-hydroxybutyrate)cysteine S-poly[(R)-3-hydroxybutyrate]cysteine A protein modification that effectively converts an L-serine residue to O3-(poly-3-hydroxybutyrate)-L-serine. Origin: Source: TermSpec: uniprot.ptm:PTM-0640 (2S)-2-amino-3-[([(3R)-3-hydroxybutanoyl]oxy)-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)]propanoic acid MOD_RES O3-poly(beta-hydroxybutyryl)lysine O3-(poly-3-hydroxybutyrate)-L-serine O3-poly(3-hydroxybutanoate)serine O3-poly(3-hydroxybutanoic acid)serine O3-poly(3-hydroxybutyrate)serine O3-poly(3-hydroxybutyric acid)serine O3-poly(beta-hydroxybutyrate)serine O3-poly[(R)-3-hydroxybutyrate]serine PSI-MOD MOD:01976 O3-(poly-3-hydroxybutyrate)-L-serine MOD:01976 A protein modification that effectively converts an L-serine residue to O3-(poly-3-hydroxybutyrate)-L-serine. PubMed:17659252 PubMed:20004640 RESID:AA0618 Origin: S Source: natural TermSpec: none (2S)-2-amino-3-[([(3R)-3-hydroxybutanoyl]oxy)-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)]propanoic acid MOD_RES O3-poly(beta-hydroxybutyryl)lysine O3-(poly-3-hydroxybutyrate)-L-serine O3-poly(3-hydroxybutanoate)serine O3-poly(3-hydroxybutanoic acid)serine O3-poly(3-hydroxybutyrate)serine O3-poly(3-hydroxybutyric acid)serine O3-poly(beta-hydroxybutyrate)serine O3-poly[(R)-3-hydroxybutyrate]serine A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-serine residue by an ester bond to form O-(L-isoglutamyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid O(beta)-(gamma-glutamyl)serine O-(L-isoglutamyl)-L-serine O3-(isoglutamyl)-serine PSI-MOD MOD:01977 Cross-link 2. O-(L-isoglutamyl)-L-serine MOD:01977 A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-serine residue by an ester bond to form O-(L-isoglutamyl)-L-serine. PubMed:17051152 RESID:AA0597 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 8 H 10 N 2 O 4 MassAvg: 198.18 MassMono: 198.064057 Origin: S, X Source: natural TermSpec: none (2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid O(beta)-(gamma-glutamyl)serine O-(L-isoglutamyl)-L-serine O3-(isoglutamyl)-serine A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using either free L-asparagine and releasing ammonia or using a peptidyl L-aspartic acid residue and releasing water. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid O(beta)-(beta-aspartyl)threonine O-(L-isoaspartyl)-L-threonine O3-(isoaspartyl)-threonine PSI-MOD MOD:01978 This is a threonine active intermediate and not an ester cross-link of peptides [JSG]. O-(L-isoaspartyl)-L-threonine MOD:01978 A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using either free L-asparagine and releasing ammonia or using a peptidyl L-aspartic acid residue and releasing water. PubMed:8706862 RESID:AA0525 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 8 H 12 N 2 O 5 MassAvg: 216.19 MassMono: 216.074621 Origin: T, X Source: natural TermSpec: none (2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid (2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid O(beta)-(beta-aspartyl)threonine O-(L-isoaspartyl)-L-threonine O3-(isoaspartyl)-threonine A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia, or using a peptidyl L-glutamine and releasing ammonia. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid 5-(threon-O3-yl)glutamate O(beta)-(gamma-glutamyl)threonine O-(L-isoglutamyl)-L-threonine O3-(isoglutamyl)threonine PSI-MOD MOD:01979 This is not an ester cross-link of peptides [JSG]. O-(L-isoglutamyl)-L-threonine MOD:01979 A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia, or using a peptidyl L-glutamine and releasing ammonia. PubMed:8706862 RESID:AA0536 DiffAvg: none DiffFormula: none DiffMono: none Formula: C 9 H 14 N 2 O 5 MassAvg: 230.22 MassMono: 230.090272 Origin: T, X Source: hypothetical TermSpec: none (2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid (2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid 5-(threon-O3-yl)glutamate O(beta)-(gamma-glutamyl)threonine O-(L-isoglutamyl)-L-threonine O3-(isoglutamyl)threonine A protein modification that effectively converts an L-arginine residue to N4-glycosyl-arginine. Origin: Source: TermSpec: Unimod: (2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid NG-beta-D-glucosylarginine omega-N-(beta-D-glucosyl)-L-arginine omega-N-glucosyl-L-arginine omega-N-glycosyl-L-arginine PSI-MOD Hex Hexose MOD:01980 omega-N-glycosyl-L-arginine MOD:01980 A protein modification that effectively converts an L-arginine residue to N4-glycosyl-arginine. PubMed:15279557 PubMed:8521968 PubMed:9536051 RESID:AA0327 Unimod:41#R Origin: R Source: natural TermSpec: none Unimod: Unimod:41 (2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid NG-beta-D-glucosylarginine omega-N-(beta-D-glucosyl)-L-arginine omega-N-glucosyl-L-arginine omega-N-glycosyl-L-arginine Hex Hexose A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 3-methyllanthionine with unresolved stereospecificity. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2,6-diamino-3-methyl-4-thiaheptanedioic acid 2-amino-3-([2-amino-2-carboxyethyl]sulfanyl)butanoic acid 2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid 2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid 3-methyllanthionine cysteine-3-L-butyrine thioether PSI-MOD MOD:01981 Cross-link 2. 3-methyllanthionine MOD:01981 A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 3-methyllanthionine with unresolved stereospecificity. PubMed:18688235 DiffAvg: -18.02 DiffFormula: C 0 H -2 N 0 O -1 S 0 DiffMono: -18.010565 Formula: C 7 H 10 N 2 O 2 S 1 MassAvg: 186.23 MassMono: 186.046299 Origin: C, T Source: natural TermSpec: none 2,6-diamino-3-methyl-4-thiaheptanedioic acid 2-amino-3-([2-amino-2-carboxyethyl]sulfanyl)butanoic acid 2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid 2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid 3-methyllanthionine cysteine-3-L-butyrine thioether modification from RESID DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0485 (trimethylammonio)ethanoic acid 1-carboxy-N,N,N-trimethylmethanazanium 2-trimethylammonioacetate MOD_RES N,N,N-trimethylglycine N,N,N-trimethylglycine cation N,N,N-trimethylglycinium N2Me3+Gly betaine carboxy-N,N,N-trimethylmethanaminium carboxymethyl-trimethylazanium glycine betaine PSI-MOD MOD:01982 N,N,N-trimethylglycine MOD:01982 modification from RESID ChEBI:17750 PubMed:23818633 PubMed:23978223 RESID:AA0619 DiffAvg: 43.09 DiffFormula: C 3 H 7 N 0 O 0 DiffMono: 43.054775 FormalCharge: 1+ Formula: C 5 H 11 N 1 O 1 MassAvg: 101.15 MassMono: 101.084064 Origin: G Source: natural TermSpec: N-term (trimethylammonio)ethanoic acid 1-carboxy-N,N,N-trimethylmethanazanium 2-trimethylammonioacetate MOD_RES N,N,N-trimethylglycine N,N,N-trimethylglycine cation N,N,N-trimethylglycinium N2Me3+Gly betaine carboxy-N,N,N-trimethylmethanaminium carboxymethyl-trimethylazanium glycine betaine A protein modification that effectively converts a glycine residue to N,N-dimethyllglycine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0484 (dimethylamino)ethanoic acid 1-carboxy-N,N-dimethylaminomethane 2-(dimethylamino)acetic acid MOD_RES N,N-dimethylglycine vitamin B16 PSI-MOD MOD:01983 N,N-dimethylglycine MOD:01983 A protein modification that effectively converts a glycine residue to N,N-dimethyllglycine. ChEBI:17724 PubMed:23818633 PubMed:23978223 RESID:AA0620 DiffAvg: 28.05 DiffFormula: C 2 H 4 N 0 O 0 DiffMono: 28.031300 Formula: C 4 H 8 N 1 O 1 MassAvg: 86.11 MassMono: 86.060589 Origin: G Source: natural TermSpec: N-term (dimethylamino)ethanoic acid 1-carboxy-N,N-dimethylaminomethane 2-(dimethylamino)acetic acid MOD_RES N,N-dimethylglycine vitamin B16 A protein modification that effectively cross-links an L-cysteine residue and an L-alanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-alanine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid (2R,5R)-2,5-diamino-5-methyl-4-thiahexanedioic acid alpha-(L-cystein-S-yl)-L-alanine PSI-MOD MOD:01984 Cross-link 2. 2-(L-cystein-S-yl)-L-alanine MOD:01984 A protein modification that effectively cross-links an L-cysteine residue and an L-alanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-alanine. PubMed:21526839 RESID:AA0621 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 6 H 8 N 2 O 2 S 1 MassAvg: 172.20 MassMono: 172.030649 Origin: A, C Source: natural TermSpec: none (2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid (2R,5R)-2,5-diamino-5-methyl-4-thiahexanedioic acid alpha-(L-cystein-S-yl)-L-alanine A protein modification that effectively cross-links an L-cysteine residue and an L-asparagine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2,4-diamino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-4-oxobutanoic acid alpha-(L-cystein-S-yl)-D-asparagine PSI-MOD MOD:01985 Cross-link 2. 2-(L-cystein-S-yl)-D-asparagine MOD:01985 A protein modification that effectively cross-links an L-cysteine residue and an L-asparagine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-asparagine. PubMed:21786372 RESID:AA0622 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 7 H 9 N 3 O 3 S 1 MassAvg: 215.23 MassMono: 215.036462 Origin: C, N Source: natural TermSpec: none (2S)-2,4-diamino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-4-oxobutanoic acid alpha-(L-cystein-S-yl)-D-asparagine A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid (2R,5R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid PSI-MOD MOD:01986 Cross-link 2. 2-(L-cystein-S-yl)-L-serine MOD:01986 A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-serine. PubMed:21526839 RESID:AA0623 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 6 H 8 N 2 O 3 S 1 MassAvg: 188.20 MassMono: 188.025563 Origin: C, S Source: natural TermSpec: none (2R)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid (2R,5R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R,5S)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid (2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid PSI-MOD MOD:01987 Cross-link 2. 2-(L-cystein-S-yl)-D-serine MOD:01987 A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-serine. PubMed:21786372 RESID:AA0624 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 6 H 8 N 2 O 3 S 1 MassAvg: 188.20 MassMono: 188.025563 Origin: C, S Source: natural TermSpec: none (2R,5S)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid (2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid (2R,5R,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid alpha-(L-cystein-S-yl)-L-threonine PSI-MOD MOD:01988 Cross-link 2. 2-(L-cystein-S-yl)-L-threonine MOD:01988 A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-threonine. PubMed:21526839 RESID:AA0625 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 7 H 10 N 2 O 3 S 1 MassAvg: 202.23 MassMono: 202.041213 Origin: C, T Source: natural TermSpec: none (2R,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid (2R,5R,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid alpha-(L-cystein-S-yl)-L-threonine A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-tyrosine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2R,5S)-2,5-diamino-5-carboxyl-6-(hydroxyphenyl)-4-thiahexanoic acid (2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid alpha-(L-cystein-S-yl)-D-tyrosine PSI-MOD MOD:01989 Cross-link 2. 2-(L-cystein-S-yl)-D-tyrosine MOD:01989 A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-tyrosine. PubMed:21526839 RESID:AA0626 DiffAvg: -2.02 DiffFormula: C 0 H -2 N 0 O 0 S 0 DiffMono: -2.015650 Formula: C 12 H 12 N 2 O 3 S 1 MassAvg: 264.30 MassMono: 264.056863 Origin: C, Y Source: natural TermSpec: none (2R,5S)-2,5-diamino-5-carboxyl-6-(hydroxyphenyl)-4-thiahexanoic acid (2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid alpha-(L-cystein-S-yl)-D-tyrosine A protein modification that effectively converts a glycine residue to a glycinium (protonated glycine). DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:01990 protonated glycine (glycinium) residue MOD:01990 A protein modification that effectively converts a glycine residue to a glycinium (protonated glycine). ChEBI:64723 PubMed:18688235 DiffAvg: 1.01 DiffFormula: C 0 H 1 N 0 O 0 DiffMono: 1.007276 FormalCharge: 1+ Formula: C 2 H 5 N 1 O 1 MassAvg: 59.07 MassMono: 59.036565 Origin: G Source: natural TermSpec: N-term A protein modification that effectively converts a glycinium (protonated glycine) residue to an N,N,N-trimethylglycine. DiffAvg: DiffFormula: DiffMono: FormalCharge: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N2Me3Gly PSI-MOD MOD:01991 For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Gly process (MOD:01982) accounts for both protonation and trimethylation. N,N,N-trimethylglycine (from glycinium) MOD:01991 A protein modification that effectively converts a glycinium (protonated glycine) residue to an N,N,N-trimethylglycine. ChEBI:17750 PubMed:23818633 PubMed:23978223 RESID:AA0619 DiffAvg: 42.08 DiffFormula: C 3 H 6 N 0 O 0 DiffMono: 42.046402 FormalCharge: 1+ Formula: C 5 H 11 N 1 O 1 MassAvg: 101.15 MassMono: 101.083515 Origin: MOD:01990 Source: natural TermSpec: N-term N2Me3Gly A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the alpha-carbon of another amino acid residue. PSI-MOD MOD:01992 alpha-carbon thioether crosslinked residues MOD:01992 A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the alpha-carbon of another amino acid residue. PubMed:18688235 A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the beta-carbon of another amino acid residue. PSI-MOD MOD:01993 These are typical lanthionine-like crosslinks. beta-carbon thioether crosslinked residues MOD:01993 A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the beta-carbon of another amino acid residue. PubMed:18688235 A protein modification that effectively converts an L-tryptophan residue to N1'-formyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N1'FoTrp PSI-MOD MOD:01994 This modifications has not been reported as commonly encountered [JSG]. N1'-formyl-L-tryptophan MOD:01994 A protein modification that effectively converts an L-tryptophan residue to N1'-formyl-L-tryptophan. PubMed:18688235 DiffAvg: 28.01 DiffFormula: C 1 H 0 N 0 O 1 DiffMono: 27.994915 Formula: C 12 H 10 N 2 O 2 MassAvg: 214.22 MassMono: 214.074228 Origin: W Source: hypothetical TermSpec: none N1'FoTrp A protein modification that effectively converts an L-tryptophan residue to N2-formyl-L-tryptophan. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N2FoTrp PSI-MOD MOD:01995 This modifications has not been reported as commonly encountered [JSG]. N2-formyl-L-tryptophan MOD:01995 A protein modification that effectively converts an L-tryptophan residue to N2-formyl-L-tryptophan. PubMed:18688235 DiffAvg: 28.01 DiffFormula: C 1 H 0 N 0 O 1 DiffMono: 27.994915 Formula: C 12 H 11 N 2 O 2 MassAvg: 215.23 MassMono: 215.082053 Origin: W Source: hypothetical TermSpec: N-term N2FoTrp A protein modification that effectively replaces a hydrogen atom with an butanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: ButRes butyrylation PSI-MOD Butyryl MOD:01996 Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). butanoylated residue MOD:01996 A protein modification that effectively replaces a hydrogen atom with an butanoyl group. PubMed:18688235 DiffAvg: 70.09 DiffFormula: C 4 H 6 O 1 DiffMono: 70.041865 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none ButRes butyrylation Butyryl A protein modification that effectively replaces a residue amino or imino hydrogen with a butanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N-butanoyl N-butanoylation N-butyryl N-butyrylation NButRes PSI-MOD MOD:01997 N-butanoylated residue MOD:01997 A protein modification that effectively replaces a residue amino or imino hydrogen with a butanoyl group. PubMed:18688235 DiffAvg: 70.09 DiffFormula: C 4 H 6 N 0 O 1 DiffMono: 70.041865 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none N-butanoyl N-butanoylation N-butyryl N-butyrylation NButRes A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a butanoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: N2ButRes PSI-MOD MOD:01998 alpha-amino butanoylated residue MOD:01998 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a butanoyl group. PubMed:18688235 DiffAvg: 70.09 DiffFormula: C 4 H 6 N 0 O 1 DiffMono: 70.041865 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: N-term N2ButRes A protein modification that effectively converts an L-lysine residue to N6-retinylidene-(11-cis)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-[(2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid PSI-MOD MOD:01999 N6-(11-cis)-retinylidene-L-lysine MOD:01999 A protein modification that effectively converts an L-lysine residue to N6-retinylidene-(11-cis)-L-lysine. PubMed:18688235 DiffAvg: 266.43 DiffFormula: C 20 H 26 N 0 O 0 DiffMono: 266.203451 Formula: C 26 H 38 N 2 O 1 MassAvg: 394.60 MassMono: 394.298414 Origin: K Source: natural TermSpec: none (2S)-2-amino-6-[(2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine (unspecified geometric isomer). DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (2S)-2-amino-6-[3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid PSI-MOD MOD:02000 N6-retinylidene-L-lysine (unspecified geometric isomer) MOD:02000 A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine (unspecified geometric isomer). PubMed:18688235 DiffAvg: 266.43 DiffFormula: C 20 H 26 N 0 O 0 DiffMono: 266.203451 Formula: C 26 H 38 N 2 O 1 MassAvg: 394.60 MassMono: 394.298414 Origin: K Source: natural TermSpec: none (2S)-2-amino-6-[3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid A protein modification that effectively replaces a hydrogen atom with a stearoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02001 stearoylated residue MOD:02001 DiffAvg: 266.47 DiffFormula: C 18 H 34 O 1 DiffMono: 266.260966 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively replaces a residue sulfanyl group with a palmitoleylsulfanyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02002 S-palmitoleylated residue MOD:02002 DiffAvg: 236.40 DiffFormula: C 16 H 28 N 0 O 1 DiffMono: 236.214016 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively replaces an O3-hydroxy hydrogen atom of L-serine with an acyl group. Origin: Source: TermSpec: PSI-MOD MOD:02003 O3-acylated L-serine MOD:02003 Origin: S Source: natural TermSpec: none A protein modification that effectively replaces an O3-hydroxy hydrogen atom of L-threonine with an acyl group. Origin: Source: TermSpec: PSI-MOD MOD:02004 O3-acylated L-threonine MOD:02004 Origin: T Source: natural TermSpec: none A protein modification that effectively replaces an sulfanyl hydrogen atom of L-cysteine with an acyl group. Origin: Source: TermSpec: PSI-MOD MOD:02005 S-acylated L-cysteine MOD:02005 Origin: C Source: natural TermSpec: none A protein modification that effectively replaces a residue sulfanyl group with a stearoylsulfanyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02006 S-stearoylated residue MOD:02006 DiffAvg: 266.47 DiffFormula: C 18 H 34 O 1 DiffMono: 266.260966 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively converts an L-lysine residue to N6-palmitoleyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02007 N6-palmitoleyl-L-lysine MOD:02007 DiffAvg: 236.40 DiffFormula: C 16 H 28 N 0 O 1 DiffMono: 236.214016 Formula: C 22 H 40 N 2 O 2 MassAvg: 364.58 MassMono: 364.308979 Origin: K Source: natural TermSpec: none A protein modification that effectively replaces a residue amino group with a palmitoleylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02008 N-palmitoleylated residue MOD:02008 DiffAvg: 236.40 DiffFormula: C 16 H 28 N 0 O 1 DiffMono: 236.214016 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively converts an L-lysine residue to N6-stearoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02009 N6-stearoyl-L-lysine MOD:02009 DiffAvg: 266.47 DiffFormula: C 18 H 34 O 1 DiffMono: 266.260966 Formula: C 24 H 46 N 2 O 2 MassAvg: 394.65 MassMono: 394.355929 Origin: K Source: natural TermSpec: none A protein modification that effectively replaces a residue amino group with a stearoylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02010 N-stearoylated residue MOD:02010 DiffAvg: 266.47 DiffFormula: C 18 H 34 O 1 DiffMono: 266.260966 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively replaces a residue amino group with a oleoylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02011 N-oleoylated residue MOD:02011 DiffAvg: 264.45 DiffFormula: C 18 H 32 N 0 O 1 DiffMono: 264.245316 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively replaces a hydrogen atom with a oleoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02012 oleoylated residue MOD:02012 DiffAvg: 264.45 DiffFormula: C 18 H 32 N 0 O 1 DiffMono: 264.245316 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively converts an L-lysine residue to N6-linoloyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02013 N6-linoloyl-L-lysine MOD:02013 DiffAvg: 262.45 DiffFormula: C 18 H 30 N 0 O 1 DiffMono: 262.229666 Formula: C 24 H 42 N 2 O 2 MassAvg: 390.63 MassMono: 390.324629 Origin: K Source: natural TermSpec: none A protein modification that effectively replaces a residue amino group with a linoloylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02014 N-linoloylated residue MOD:02014 DiffAvg: 262.45 DiffFormula: C 18 H 30 N 0 O 1 DiffMono: 262.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively replaces a hydrogen atom with a linoloyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02015 linoloylated residue MOD:02015 DiffAvg: 262.45 DiffFormula: C 18 H 30 N 0 O 1 DiffMono: 262.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively converts an L-lysine residue to N6-arachidonoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02016 N6-arachidonoyl-L-lysine MOD:02016 DiffAvg: 286.49 DiffFormula: C 20 H 30 N 0 O 1 DiffMono: 286.229666 Formula: C 26 H 42 N 2 O 2 MassAvg: 414.67 MassMono: 414.324629 Origin: K Source: natural TermSpec: none A protein modification that effectively replaces a residue amino group with an arachidonoylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02017 N-arachidonoylated residue MOD:02017 DiffAvg: 286.49 DiffFormula: C 20 H 30 N 0 O 1 DiffMono: 286.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively replaces a hydrogen atom with an arachidonoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02018 arachidonoylated residue MOD:02018 DiffAvg: 286.49 DiffFormula: C 20 H 30 N 0 O 1 DiffMono: 286.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively converts an L-lysine residue to N6-timnodonoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02019 N6-timnodonoyl-L-lysine MOD:02019 DiffAvg: 284.48 DiffFormula: C 20 H 28 N 0 O 1 DiffMono: 284.214016 Formula: C 26 H 40 N 2 O 2 MassAvg: 412.66 MassMono: 412.308979 Origin: K Source: natural TermSpec: none A protein modification that effectively replaces a residue amino group with a timnodonoylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02020 N-timnodonoylated residue MOD:02020 DiffAvg: 284.48 DiffFormula: C 20 H 28 N 0 O 1 DiffMono: 284.214016 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively replaces a hydrogen atom with a timnodonoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02021 timnodonoylated residue MOD:02021 DiffAvg: 284.48 DiffFormula: C 20 H 28 N 0 O 1 DiffMono: 284.214016 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively converts an L-lysine residue to N6-cervonoyl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02022 N6-cervonoyl-L-lysine MOD:02022 DiffAvg: 310.53 DiffFormula: C 22 H 30 N 0 O 1 DiffMono: 310.229666 Formula: C 28 H 42 N 2 O 2 MassAvg: 438.71 MassMono: 438.324629 Origin: K Source: natural TermSpec: none A protein modification that effectively replaces a residue amino group with a cervonoylamino group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02023 N-cervonoylated residue MOD:02023 DiffAvg: 310.53 DiffFormula: C 22 H 30 N 0 O 1 DiffMono: 310.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively replaces a hydrogen atom with a cervonoyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02024 cervonoylated residue MOD:02024 DiffAvg: 310.53 DiffFormula: C 22 H 30 N 0 O 1 DiffMono: 310.229666 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none A protein modification that effectively converts the alpha amino group of a glutamine residue to glutaminyl glutamic acid by forming an isopeptide bond with the side chain carboxyl group of a free glutamic acid. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02025 5-glutaminyl glutamic acid MOD:02025 A protein modification that effectively converts the alpha amino group of a glutamine residue to glutaminyl glutamic acid by forming an isopeptide bond with the side chain carboxyl group of a free glutamic acid. PubMed:28801462 DiffAvg: 128.13 DiffFormula: C 5 H 8 N 2 O 2 DiffMono: 128.058576 Formula: C 10 H 15 N 3 O 5 MassAvg: 257.24 MassMono: 257.101167 Origin: E Source: natural TermSpec: none A protein modification that effectively cross-links an L-cysteinyl-L-glycine dipeptide and an L-cysteine residue by a disulfide bond to form S-(cysteinyl-glycyl)-L-cysteine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: PSI-MOD MOD:02026 Glutamyl-transpeptidase cleaves glutathione into cysteinylglycine (Cys-Gly) and a Glu residue. [PubMed:28537416] S-(cysteinyl-glycyl)-L-cysteine MOD:02026 A protein modification that effectively cross-links an L-cysteinyl-L-glycine dipeptide and an L-cysteine residue by a disulfide bond to form S-(cysteinyl-glycyl)-L-cysteine. PubMed:20594348 PubMed:27936627 PubMed:29627744 DiffAvg: 176.17 DiffFormula: C 5 H 8 N 2 O 3 S 1 DiffMono: 176.025563 Formula: C 8 H 13 N 3 O 4 S 2 MassAvg: 279.33 MassMono: 279.034748 Origin: C Source: natural TermSpec: none A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a URM1 protein. Origin: Source: TermSpec: PSI-MOD MOD:02027 urmylated lysine MOD:02027 A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a URM1 protein. PubMed:10713047 PubMed:21209336 Origin: K Source: natural TermSpec: none A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: (4-methylpiperazin-1-yl)acetyl PSI-MOD iTRAQ MOD:02028 The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. Four versions of chemically identical iTRAQ4plex moyeties, but with different isotope distribution. This modification is calculated as the average of the four species. It has no isotopic distribution reality, the exact mass does not correspond to any real isotopic distribution. iTRAQ4plex reporter+balance reagent acylated residue, average mass modification MOD:02028 A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups. Unimod:214 DiffAvg: 144.10 DiffFormula: none DiffMono: 144.102411 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none (4-methylpiperazin-1-yl)acetyl iTRAQ A protein modification that effectively specifies the boundary conformation of two adjacent source amino acid residues, the second (C-term side) being a L-proline, where the carbonyl group of the amide bond of the N-side of the L-proline is positioned such that the organodiyl group is in the cis orientation (omega=0) DiffAvg: DiffFormula: DiffMono: Origin: Source: TermSpec: PSI-MOD MOD:02029 cis-peptidyl-L-proline MOD:02029 A protein modification that effectively specifies the boundary conformation of two adjacent source amino acid residues, the second (C-term side) being a L-proline, where the carbonyl group of the amide bond of the N-side of the L-proline is positioned such that the organodiyl group is in the cis orientation (omega=0) ChEBI:83833 PubMed:15311922 PubMed:15735342 PubMed:24116866 PubMed:5485910 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Origin: X, P Source: natural TermSpec: none A protein modification that effectively specifies the boundary conformation of two adjacent source amino acid residues, the second (C-term side) being a L-proline, where the carbonyl group of the amide bond of the N-side of the L-proline is positioned such that the organodiyl group is in the trans orientation (omega=180) DiffAvg: DiffFormula: DiffMono: Origin: Source: TermSpec: PSI-MOD MOD:02030 trans-peptidyl-L-proline MOD:02030 A protein modification that effectively specifies the boundary conformation of two adjacent source amino acid residues, the second (C-term side) being a L-proline, where the carbonyl group of the amide bond of the N-side of the L-proline is positioned such that the organodiyl group is in the trans orientation (omega=180) ChEBI:83834 PubMed:15311922 PubMed:15735342 PubMed:24116866 PubMed:5485910 DiffAvg: 0.00 DiffFormula: C 0 H 0 N 0 O 0 DiffMono: 0.000000 Origin: X, P Source: natural TermSpec: none modification from Unimod N-linked glycosylation, dHex Hex(4) HexNAc(5) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD dHex Hex(4) HexNAc(5) MOD:02031 dHex1Hex4HexNAc5 N4-glycosylated asparagine MOD:02031 modification from Unimod N-linked glycosylation, dHex Hex(4) HexNAc(5) PubMed:33135055 Unimod:1519 DiffAvg: 1810.68 DiffFormula: C 70 H 115 N 5 O 49 DiffMono: 1809.666065 Formula: C 74 H 121 N 7 O 51 GNOme: GNO:G03382KH MassAvg: 1924.78 MassMono: 1923.708993 Origin: N Source: natural TermSpec: none Unimod: Unimod:1519 dHex Hex(4) HexNAc(5) modification from Unimod N-linked glycosylation, dHex(2) Hex(4) HexNAc(5) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD dHex(2) Hex(4) HexNAc(5) MOD:02032 dHex2Hex4HexNAc5 N4-glycosylated asparagine MOD:02032 modification from Unimod N-linked glycosylation, dHex(2) Hex(4) HexNAc(5) PubMed:33135055 Unimod:1785 DiffAvg: 1956.82 DiffFormula: C 76 H 125 N 5 O 53 DiffMono: 1955.723974 Formula: C 80 H 131 N 7 O 55 GNOme: GNO:G70418MS MassAvg: 2070.92 MassMono: 2069.766901 Origin: N Source: natural TermSpec: none Unimod: Unimod:1785 dHex(2) Hex(4) HexNAc(5) modification from Unimod N-linked glycosylation, dHex Hex(5) HexNAc(3) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD dHex Hex(5) HexNAc(3) MOD:02033 dHex1Hex5HexNAc3 N4-glycosylated asparagine MOD:02033 modification from Unimod N-linked glycosylation, dHex Hex(5) HexNAc(3) PubMed:33135055 Unimod:1484 DiffAvg: 1566.43 DiffFormula: C 60 H 99 N 3 O 44 DiffMono: 1565.560143 Formula: C 64 H 105 N 5 O 46 GNOme: GNO:G82119TF MassAvg: 1680.53 MassMono: 1679.603071 Origin: N Source: natural TermSpec: none Unimod: Unimod:1484 dHex Hex(5) HexNAc(3) modification from Unimod N-linked glycosylation, dHex Hex(3) HexNAc(6) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD dHex Hex(3) HexNAc(6) MOD:02034 dHex1Hex3HexNAc6 N4-glycosylated asparagine MOD:02034 modification from Unimod N-linked glycosylation, dHex Hex(3) HexNAc(6) PubMed:33135055 Unimod:1781 DiffAvg: 1851.73 DiffFormula: C 72 H 118 N 6 O 49 DiffMono: 1850.692614 Formula: C 76 H 124 N 8 O 51 GNOme: GNO:G50757KG MassAvg: 1965.83 MassMono: 1964.735542 Origin: N Source: natural TermSpec: none Unimod: Unimod:1781 dHex Hex(3) HexNAc(6) modification from Unimod N-linked glycosylation, dHex Hex(6) HexNAc(3) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD dHex Hex(6) HexNAc(3) MOD:02035 dHex1Hex6HexNAc3 N4-glycosylated asparagine MOD:02035 modification from Unimod N-linked glycosylation, dHex Hex(6) HexNAc(3) PubMed:33135055 Unimod:1509 DiffAvg: 1728.57 DiffFormula: C 66 H 109 N 3 O 49 DiffMono: 1727.612967 Formula: C 70 H 115 N 5 O 51 GNOme: GNO:G84820NF MassAvg: 1842.67 MassMono: 1841.655894 Origin: N Source: natural TermSpec: none Unimod: Unimod:1509 dHex Hex(6) HexNAc(3) modification from Unimod N-linked glycosylation, Hex(9)HexNAc(2) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD M9/Man9 MOD:02036 Hex9HexNAc2 N4-glycosylated asparagine MOD:02036 modification from Unimod N-linked glycosylation, Hex(9)HexNAc(2) PubMed:33135055 Unimod:1531 DiffAvg: 1865.66 DiffFormula: C 70 H 116 N 2 O 55 DiffMono: 1864.634156 Formula: C 74 H 122 N 4 O 57 GNOme: GNO:G70101JE MassAvg: 1979.76 MassMono: 1978.677083 Origin: N Source: natural TermSpec: none Unimod: Unimod:1531 M9/Man9 modification from Unimod N-linked glycosylation, Hex(7) HexNAc(2) DiffAvg: DiffFormula: DiffMono: Formula: GNOme: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD M7/Man7 MOD:02037 Hex7HexNAc2 N4-glycosylated asparagine MOD:02037 modification from Unimod N-linked glycosylation, Hex(7) HexNAc(2) PubMed:33135055 Unimod:1480 DiffAvg: 1541.38 DiffFormula: C 58 H 96 N 2 O 45 DiffMono: 1540.528509 Formula: C 62 H 102 N 4 O 47 GNOme: GNO:G05724UK MassAvg: 1655.48 MassMono: 1654.571436 Origin: N Source: natural TermSpec: none Unimod: Unimod:1480 M7/Man7 A protein modification that effectively replaces one hydrogen atom of an L-histidine residue with one methyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0176 MOD_RES Methylhistidine Me1His methylh PSI-MOD Methyl MOD:02038 monomethylated L-histidine MOD:02038 A protein modification that effectively replaces one hydrogen atom of an L-histidine residue with one methyl group. DeltaMass:215 OMSSA:77 Unimod:34#H DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 7 H 9 N 3 O 1 MassAvg: 151.17 MassMono: 151.074562 Origin: H Source: natural TermSpec: none Unimod: Unimod:34 MOD_RES Methylhistidine Me1His methylh Methyl A protein modification that effectively replaces a hydrogen group with a amino group Origin: Source: TermSpec: AmRes PSI-MOD MOD:02039 aminated residue MOD:02039 Origin: X Source: none TermSpec: none AmRes A protein modification that contains an L-alanine residue crosslinked to one or more amino acid residues. Origin: XlnkAla PSI-MOD MOD:02040 crosslinked L-alanine residue MOD:02040 A protein modification that contains an L-alanine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: A XlnkAla A protein modification that contains an L-arginine residue crosslinked to one or more amino acid residues. Origin: XlnkArg PSI-MOD MOD:02041 crosslinked L-arginine residue MOD:02041 A protein modification that contains an L-arginine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: R XlnkArg A protein modification that contains an L-asparagine residue crosslinked to one or more amino acid residues. Origin: XlnkAsn PSI-MOD MOD:02042 crosslinked L-asparagine residue MOD:02042 A protein modification that contains an L-asparagine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: N XlnkAsn A protein modification that contains an L-aspartic acid residue crosslinked to one or more amino acid residues. Origin: XlnkAsp PSI-MOD MOD:02043 crosslinked L-aspartic acid residue MOD:02043 A protein modification that contains an L-aspartic acid residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: D XlnkAsp A protein modification that contains an L-cysteine residue crosslinked to one or more amino acid residues. Origin: XlnkCys PSI-MOD MOD:02044 crosslinked L-cysteine residue MOD:02044 A protein modification that contains an L-cysteine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: C XlnkCys A protein modification that contains an L-glutamic acid residue crosslinked to one or more amino acid residues. Origin: XlnkGlu PSI-MOD MOD:02045 crosslinked L-glutamic acid residue MOD:02045 A protein modification that contains an L-glutamic acid residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: E XlnkGlu A protein modification that contains an L-glutamine residue crosslinked to one or more amino acid residues. Origin: XlnkGln PSI-MOD MOD:02046 crosslinked L-glutamine residue MOD:02046 A protein modification that contains an L-glutamine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: Q XlnkGln A protein modification that contains a glycine residue crosslinked to one or more amino acid residues. Origin: XlnkGly PSI-MOD MOD:02047 crosslinked glycine residue MOD:02047 A protein modification that contains a glycine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: G XlnkGly A protein modification that contains an L-histidine residue crosslinked to one or more amino acid residues. Origin: XlnkHis PSI-MOD MOD:02048 crosslinked L-histidine residue MOD:02048 A protein modification that contains an L-histidine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: H XlnkHis A protein modification that contains an L-isoleucine residue crosslinked to one or more amino acid residues. Origin: XlnkIle PSI-MOD MOD:02049 crosslinked L-isoleucine residue MOD:02049 A protein modification that contains an L-isoleucine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: I XlnkIle A protein modification that contains an L-leucine residue crosslinked to one or more amino acid residues. Origin: XlnkLeu PSI-MOD MOD:02050 crosslinked L-leucine residue MOD:02050 A protein modification that contains an L-leucine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: L XlnkLeu A protein modification that contains an L-lysine residue crosslinked to one or more amino acid residues. Origin: XlnkLys PSI-MOD MOD:02051 crosslinked L-lysine residue MOD:02051 A protein modification that contains an L-lysine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: K XlnkLys A protein modification that contains an L-methionine residue crosslinked to one or more amino acid residues. Origin: XlnkMet PSI-MOD MOD:02052 crosslinked L-methionine residue MOD:02052 A protein modification that contains an L-methionine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: M XlnkMet A protein modification that contains an L-phenylalanine residue crosslinked to one or more amino acid residues. Origin: XlnkPhe PSI-MOD MOD:02053 crosslinked L-phenylalanine residue MOD:02053 A protein modification that contains an L-phenylalanine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: F XlnkPhe A protein modification that contains an L-proline residue crosslinked to one or more amino acid residues. Origin: XlnkPro PSI-MOD MOD:02054 crosslinked L-proline residue MOD:02054 A protein modification that contains an L-proline residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: P XlnkPro A protein modification that contains an L-serine residue crosslinked to one or more amino acid residues. Origin: XlnkSer PSI-MOD MOD:02055 crosslinked L-serine residue MOD:02055 A protein modification that contains an L-serine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: S XlnkSer A protein modification that contains an L-threonine residue crosslinked to one or more amino acid residues. Origin: XlnkThr PSI-MOD MOD:02056 crosslinked L-threonine residue MOD:02056 A protein modification that contains an L-threonine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: T XlnkThr A protein modification that contains an L-tryptophan residue crosslinked to one or more amino acid residues. Origin: XlnkTrp PSI-MOD MOD:02057 crosslinked L-tryptophan residue MOD:02057 A protein modification that contains an L-tryptophan residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: W XlnkTrp A protein modification that contains an L-tyrosine residue crosslinked to one or more amino acid residues. Origin: XlnkTyr PSI-MOD MOD:02058 crosslinked L-tyrosine residue MOD:02058 A protein modification that contains an L-tyrosine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: Y XlnkTyr A protein modification that contains an L-valine residue crosslinked to one or more amino acid residues. Origin: XlnkVal PSI-MOD MOD:02059 crosslinked L-valine residue MOD:02059 A protein modification that contains an L-valine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: V XlnkVal A protein modification that contains an D-asparagine residue crosslinked to one or more amino acid residues. Origin: XlnkDAsn PSI-MOD MOD:02060 crosslinked D-asparagine residue MOD:02060 A protein modification that contains an D-asparagine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: MOD:00203 XlnkDAsn A protein modification that contains an L-selenocysteine residue crosslinked to one or more amino acid residues. Origin: PSI-MOD MOD:02061 crosslinked L-selenocysteine residue MOD:02061 A protein modification that contains an L-selenocysteine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: U A protein modification that contains an N-formyl-L-methionine residue crosslinked to one or more amino acid residues. Origin: PSI-MOD MOD:02062 crosslinked N-formyl-L-methionine residue MOD:02062 A protein modification that contains an N-formyl-L-methionine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: MOD:00030 A protein modification that contains an D-phenylalanine residue crosslinked to one or more amino acid residues. Origin: XlnkDPhe PSI-MOD MOD:02063 crosslinked D-phenylalanine residue MOD:02063 A protein modification that contains an D-phenylalanine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: F XlnkDPhe A protein modification that contains an D-serine residue crosslinked to one or more amino acid residues. Origin: XlnkDSer PSI-MOD MOD:02064 crosslinked D-serine residue MOD:02064 A protein modification that contains an D-serine residue crosslinked to one or more amino acid residues. PubMed:18688235 Origin: S XlnkDSer A protein modification that contains an L-alanine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02065 metal or metal cluster coordinated L-alanine residue MOD:02065 A protein modification that contains an L-alanine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: A A protein modification that contains an L-aspartic acid residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02066 metal or metal cluster coordinated L-aspartic acid residue MOD:02066 A protein modification that contains an L-aspartic acid residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: D A protein modification that contains an L-cysteine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02067 metal or metal cluster coordinated L-cysteine residue MOD:02067 A protein modification that contains an L-cysteine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: C A protein modification that contains an L-glutamic acid residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02068 metal or metal cluster coordinated L-glutamic acid residue MOD:02068 A protein modification that contains an L-glutamic acid residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: E A protein modification that contains an L-glutamine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02069 metal or metal cluster coordinated L-glutamine residue MOD:02069 A protein modification that contains an L-glutamine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: Q A protein modification that contains an L-histidine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02070 metal or metal cluster coordinated L-histidine residue MOD:02070 A protein modification that contains an L-histidine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: H A protein modification that contains an L-methionine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02071 metal or metal cluster coordinated L-methionine residue MOD:02071 A protein modification that contains an L-methionine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: M A protein modification that contains an L-serine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02072 metal or metal cluster coordinated L-serine residue MOD:02072 A protein modification that contains an L-serine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: S A protein modification that contains an L-selenocysteine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02073 metal or metal cluster coordinated L-selenocysteine residue MOD:02073 A protein modification that contains an L-selenocysteine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: U A protein modification that contains an L-lysine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02074 metal or metal cluster coordinated L-lysine residue MOD:02074 A protein modification that contains an L-lysine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: K A protein modification that contains an L-tyrosine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02075 metal or metal cluster coordinated L-tyrosine residue MOD:02075 A protein modification that contains an L-tyrosine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: Y A protein modification that contains an L-arginine residue coordinated to one or more metal atoms or metal clusters. Origin: PSI-MOD MOD:02076 metal or metal cluster coordinated L-arginine residue MOD:02076 A protein modification that contains an L-arginine residue coordinated to one or more metal atoms or metal clusters. PubMed:18688235 Origin: R A protein modification that effectively replaces a hydrogen atom with an nitrosyl (NO) group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Nitrosyl MOD:02077 nitrosylated residue MOD:02077 A protein modification that effectively replaces a hydrogen atom with an nitrosyl (NO) group. PubMed:10442087 PubMed:11562475 PubMed:15688001 PubMed:8626764 PubMed:8637569 Unimod:275 DiffAvg: 29.00 DiffFormula: C 0 H -1 N 1 O 1 S 0 DiffMono: 28.990164 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none Unimod: Unimod:275 Nitrosyl A protein modification that effectively replaces one or more hydrogen atoms with one or more acetyl groups. Origin: Source: TermSpec: AcRes PSI-MOD Acetyl MOD:02078 acetylated residue MOD:02078 A protein modification that effectively replaces one or more hydrogen atoms with one or more acetyl groups. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 Origin: X Source: artifact TermSpec: none AcRes Acetyl A protein modification that effectively replaces one hydrogen atom with one acetyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Ac2Res PSI-MOD Diacetyl MOD:02079 Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). From DeltaMass: Average Mass: 42 diacetylated residue MOD:02079 A protein modification that effectively replaces one hydrogen atom with one acetyl group. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 Unimod:1 DiffAvg: 84.07 DiffFormula: C 4 H 4 N 0 O 2 DiffMono: 84.021129 Formula: none MassAvg: none MassMono: none Origin: X Source: artifact TermSpec: none Ac2Res Diacetyl A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: Ac2Ser PSI-MOD MOD:02080 diacetylated L-serine MOD:02080 A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine. PubMed:18688235 DiffAvg: 84.07 DiffFormula: C 4 H 4 N 0 O 2 DiffMono: 84.021129 Formula: C 7 H 10 N 1 O 4 MassAvg: 172.16 MassMono: 172.060983 Origin: S Source: natural Ac2Ser A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a succinyl group. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: PSI-MOD Succinyl MOD:02081 alpha-amino succinylated residue MOD:02081 A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a succinyl group. PubMed:11857757 PubMed:12175151 Unimod:64#N-term DiffAvg: 100.07 DiffFormula: C 4 H 4 O 3 DiffMono: 100.016044 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: N-term Unimod: Unimod:64 Succinyl A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) and a water moiety from a residue. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 2dHdH2ORes PSI-MOD MOD:02082 didehydrogenated and dehydrated residue MOD:02082 A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) and a water moiety from a residue. Unimod:401 DiffAvg: -20.03 DiffFormula: C 0 H -4 N 0 O -1 DiffMono: -20.026215 Formula: none MassAvg: none MassMono: none Origin: X Source: none TermSpec: none 2dHdH2ORes A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through the 4-alpha position of FMN. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 4aFMNRes PSI-MOD MOD:02083 4alpha-FMN modified residue MOD:02083 A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through the 4-alpha position of FMN. PubMed:18688235 DiffAvg: 456.35 DiffFormula: C 17 H 21 N 4 O 9 P 1 DiffMono: 456.104615 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none 4aFMNRes A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through the 6 position of FMN. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 6-FMNRes PSI-MOD MOD:02084 6-FMN modified residue MOD:02084 A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through the 6 position of FMN. PubMed:18688235 DiffAvg: 454.33 DiffFormula: C 17 H 19 N 4 O 9 P 1 DiffMono: 454.088965 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none 6-FMNRes A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through the 8-alpha position of FMN. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: 8a-FMNRes PSI-MOD MOD:02085 8alpha-FMN modified residue MOD:02085 A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through the 8-alpha position of FMN. PubMed:18688235 DiffAvg: 454.33 DiffFormula: C 17 H 19 N 4 O 9 P 1 DiffMono: 454.088965 Formula: none MassAvg: none MassMono: none Origin: X Source: natural TermSpec: none 8a-FMNRes A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a bromine atom. Origin: Source: TermSpec: BrPhe PSI-MOD MOD:02086 brominated phenylalanine MOD:02086 A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a bromine atom. PubMed:18688235 Origin: F Source: none TermSpec: none BrPhe A protein modification that effectively results from forming an adduct with one or more ADP-ribose moieties or to modified residues through formation of a glycosidic bond. Origin: Source: TermSpec: ADPRibRes PSI-MOD MOD:02087 adenosine diphosphoribosyl (ADP-ribosyl) modified residue MOD:02087 A protein modification that effectively results from forming an adduct with one or more ADP-ribose moieties or to modified residues through formation of a glycosidic bond. DeltaMass:0 Origin: X Source: natural TermSpec: none ADPRibRes A protein modification that effectively replaces a natural, standard, encoded residue. Origin: Source: TermSpec: PSI-MOD MOD:02088 This represents the replacement of an encoded residue in a polypeptide, and must be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution. natural, standard, encoded residue substitution MOD:02088 A protein modification that effectively replaces a natural, standard, encoded residue. PubMed:18688235 Origin: X Source: natural TermSpec: none A protein modification that effectively crosslinks an L-serine residue and 5'-phosphouridine through a phosphodiester bond to form O-(phospho-5'-uridine)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0501 MOD_RES O-UMP-serine OUMPSer PSI-MOD PhosphoUridine MOD:02089 O-(phospho-5'-uridine)-L-serine MOD:02089 A protein modification that effectively crosslinks an L-serine residue and 5'-phosphouridine through a phosphodiester bond to form O-(phospho-5'-uridine)-L-serine. ChEBI:156051 DeltaMass:0 PubMed:22504181 Unimod:417#S DiffAvg: 306.17 DiffFormula: C 9 H 11 N 2 O 8 P 1 DiffMono: 306.025302 Formula: C 12 H 16 N 3 O 9 P 1 MassAvg: 377.24 MassMono: 377.062416 Origin: S Source: natural TermSpec: none Unimod: Unimod:417 MOD_RES O-UMP-serine OUMPSer PhosphoUridine A protein modification that effectively modifies an L-threonine residue with 5'-phosphouridine through a phosphodiester bond to form O-(phospho-5'-uridine)-L-threonine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0502 MOD_RES O-UMP-threonine OUMPThr PSI-MOD PhosphoUridine MOD:02090 O-(phospho-5'-uridine)-L-threonine MOD:02090 A protein modification that effectively modifies an L-threonine residue with 5'-phosphouridine through a phosphodiester bond to form O-(phospho-5'-uridine)-L-threonine. ChEBI:156052 DeltaMass:0 PubMed:22504181 Unimod:417#T DiffAvg: 306.17 DiffFormula: C 9 H 11 N 2 O 8 P 1 DiffMono: 306.025302 Formula: C 13 H 18 N 3 O 9 P 1 MassAvg: 391.27 MassMono: 391.078066 Origin: T Source: natural TermSpec: none Unimod: Unimod:417 MOD_RES O-UMP-threonine OUMPThr PhosphoUridine A protein modification that effectively modifies an L-serine residue with 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-serine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0651 MOD_RES O-AMP-serine PSI-MOD Phosphoadenosine MOD:02091 O-(phospho-5'-adenosine)-L-serine MOD:02091 A protein modification that effectively modifies an L-serine residue with 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-serine. PubMed:21472612 Unimod:405#S DiffAvg: 329.21 DiffFormula: C 10 H 12 N 5 O 6 P 1 DiffMono: 329.052520 Formula: C 13 H 17 N 6 O 8 P 1 MassAvg: 416.28 MassMono: 416.084549 Origin: S Source: natural TermSpec: none Unimod: Unimod:405 MOD_RES O-AMP-serine Phosphoadenosine A protein modification that effectively converts an L-cysteine residue to form S-methylbutanedioic acid-L-cysteine by alkylation with itaconate through a thioether bond. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0676 MOD_RES S-(2,3-dicarboxypropyl)cysteine PSI-MOD MOD:02092 S-methylbutanedioic acid-L-cysteine MOD:02092 A protein modification that effectively converts an L-cysteine residue to form S-methylbutanedioic acid-L-cysteine by alkylation with itaconate through a thioether bond. PubMed:29590092 DiffAvg: 130.10 DiffFormula: C 5 H 6 N 0 O 4 P 0 S 0 DiffMono: 130.026609 Formula: C 8 H 11 N 1 O 5 P 0 S 1 MassAvg: 233.24 MassMono: 233.035793 Origin: C Source: natural TermSpec: none MOD_RES S-(2,3-dicarboxypropyl)cysteine A protein modification that effectively converts an L-lysine residue to N6-(2-hydroxyisobutanoyl)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: Unimod: uniprot.ptm:PTM-0638 MOD_RES N6-(2-hydroxyisobutyryl)lysine PSI-MOD MOD:02093 N6-(2-hydroxyisobutanoyl)-L-lysine MOD:02093 A protein modification that effectively converts an L-lysine residue to N6-(2-hydroxyisobutanoyl)-L-lysine. ChEBI:144968 PubMed:24681537 PubMed:29775581 Unimod:1849 DiffAvg: 86.09 DiffFormula: C 4 H 6 N 0 O 2 DiffMono: 86.036779 Formula: C 10 H 18 N 2 O 3 MassAvg: 214.27 MassMono: 214.131742 Origin: K Source: natural TermSpec: none Unimod: Unimod:1849 MOD_RES N6-(2-hydroxyisobutyryl)lysine A protein modification that effectively converts an L-lysine residue to N6-((3R)-3-hydroxybutanoyl)-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0499 MOD_RES N6-(beta-hydroxybutyryl)lysine PSI-MOD MOD:02094 N6-((3R)-3-hydroxybutanoyl)-L-lysine MOD:02094 A protein modification that effectively converts an L-lysine residue to N6-((3R)-3-hydroxybutanoyl)-L-lysine. ChEBI:149490 PubMed:27105115 DiffAvg: 86.09 DiffFormula: C 4 H 6 N 0 O 2 DiffMono: 86.036779 Formula: C 10 H 18 N 2 O 3 MassAvg: 214.27 MassMono: 214.131742 Origin: K Source: natural TermSpec: none MOD_RES N6-(beta-hydroxybutyryl)lysine A protein modification that effectively converts an L-lysine residue to N6-glutaryl-L-lysine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0487 MOD_RES N6-glutaryllysine PSI-MOD MOD:02095 N6-glutaryl-L-lysine MOD:02095 A protein modification that effectively converts an L-lysine residue to N6-glutaryl-L-lysine. ChEBI:87828 PubMed:24703693 DiffAvg: 114.10 DiffFormula: C 5 H 6 N 0 O 3 DiffMono: 114.031694 Formula: C 11 H 18 N 2 O 4 MassAvg: 242.28 MassMono: 242.126657 Origin: K Source: natural TermSpec: none MOD_RES N6-glutaryllysine A protein modification that effectively converts a D-asparagine residue to N4-methyl-D-asparagine. DiffAvg: DiffFormula: DiffMono: Formula: MassAvg: MassMono: Origin: Source: TermSpec: uniprot.ptm:PTM-0691 MOD_RES N4-methyl-D-asparagine N4-methylated D-asparagine PSI-MOD MOD:02096 N4-methyl-D-asparagine MOD:02096 A protein modification that effectively converts a D-asparagine residue to N4-methyl-D-asparagine. ChEBI:149514 PubMed:22983711 DiffAvg: 14.03 DiffFormula: C 1 H 2 N 0 O 0 DiffMono: 14.015650 Formula: C 5 H 8 N 2 O 2 MassAvg: 128.13 MassMono: 128.058578 Origin: N Source: natural TermSpec: none MOD_RES N4-methyl-D-asparagine N4-methylated D-asparagine A protein modification that modifies a D-asparagine residue. ModDAsn PSI-MOD MOD:02097 modified D-asparagine residue MOD:02097 A protein modification that modifies a D-asparagine residue. PubMed:18688235 ModDAsn 1.031.6 13:06:2021 12:12 PSI-MOD 1.2 Joshua Klein Annotation note 01 - "[PSI-MOD:ref]" has been replaced by PubMed:18688235. Annotation note 02 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by a hash symbol "#" and a 3 or 4 character label. When an entry in the RESID Database is annotated as a general modification with the same enzymatic activity producing different chemical structures depending on natural variation in the nonproteinaceous substrate, on secondary modifications that do not change the nature of the primary modification, or on a combination of a primary and one or more secondary modifications on the same residue, then the PSI-MOD definition for each different instance carries the RESID cross-reference followed by the special tag "#var". Annotation note 03 - When an entry in the Unimod database is annotated as a general modification, and one or more instance sites are listed, then the PSI-MOD definition for each different site instance carries the Unimod cross-reference followed by a hash symbol and an amino acid code, "N-term" or "C-term". Annotation note 04 - The elemental formulas are in strict alphabetical order, not in CAS ("C" and "H" first) order. Isotope numbers are in parentheses before the element symbol, and an element should not occur in a formula both with and without an isotope number. In difference formulas, counts can be zero or negative. Annotation note 05 - In entries with an isotope indicator in the formula, average masses are meaningless and are assigned the value equal to the monoisotopic mass, but rounded to a lower precision; monoisotopic masses are calculated by using the masses for the indicated isotopes and the most common isotopes for other elements without isotope indicators in the formulas. Annotation note 06 - For cross-link modifications, the number following "Cross-link" in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. This usage differs from RESID, where the cross-link number indicates the maximum number of peptide chains that can be cross-linked. Annotation note 07 - The synonym cross-reference "MOD:old name" has been replaced by "MOD:alternate name". Annotation note 08 - The DeltaMass listings for free amino acids have been removed. Most Unimod entries that have not been "approved" have by general agreement not been incorporated unless there has been a request for a specific term by a PRIDE submitter. Annotation note 09 - The Open Mass Spectrometry Search Algorithm, OMSSA, enumerated list of modifications are being incorporated. The string values are synonyms with the synonymtypedef "OMSSA-label", and their integer values (which are supposed to be stable) are definition cross-references. Annotation note 10 - GNOme is the Glycan Naming and Subsumption Ontology (https://gnome.glyomics.org/), an ontology for the support of glycomics. PSI-MOD does not have all possible glycans in its entries, just the ones that are noted to be on proteins and have been requested for addition. GNOme uses GlyTouCan (http://glytoucan.org/) to provide stable accessions for glycans described at varyious degrees of characterization, including compositions (no linkage) and topologies (no carbon bond positions or anomeric configurations). ISO-8601 date: 2022-06-13 12:12Z PSI-MOD version: 1.031.6 RESID release: 75.00 'Entity A' derives_from 'Entity B' implies that 'Entity A' is chemically derived from 'Entity B'. PSI-MOD derives_from derives from 'Entity A' derives_from 'Entity B' implies that 'Entity A' is chemically derived from 'Entity B'. PubMed:18688235 'Entity A' has_functional_parent 'Entity B' implies that 'Entity B' has at least one chacteristic group from which 'Entity A' can be derived by functional modification. PSI-MOD has_functional_parent This relationship indicates that the formula and mass of the child are not inherited from the mass of the parent. has functional parent 'Entity A' has_functional_parent 'Entity B' implies that 'Entity B' has at least one chacteristic group from which 'Entity A' can be derived by functional modification. PubMed:18688235