Andre Dekker has_age The object is the elapsed time since birth of the subject. Andre Dekker has_intent Andre Dekker has_heart_disorder Andre Dekker has_neoplasm Andre Dekker has_age_at_pathology Andre Dekker has_age_at_diagnosis Andre Dekker has_age_at_start_rt Andre Dekker has_biological_sex Andre Dekker brings_about Acts on or influences an entity. Andre Dekker has_disease Andre Dekker has_histology Andre Dekker has_finding Andre Dekker has_prescribed_radiation_dose Andre Dekker has_procedure Andre Dekker has_stage Andre Dekker has_survival Andre Dekker has_unit Andre Dekker has_vital_status Andre Dekker is_diagnosed_with Andre Dekker is_staged_with Andre Dekker temporally_related_to Related in time by preceding, co-occuring with, or following. Andre Dekker follows Occurs earlier in time. This includes antedates, comes before, is in advance of, predates, and is prior to. Andre Dekker is_adjuvant_to Andre Dekker precedes Andre Dekker co-occurs_with Occurs at the same time as, together with, or jointly. This includes is co-incident with, is concurrent with, is contemporaneous with, accompanies, coexists with, and is concomitant with. Andre Dekker is_concurrent_with Andre Dekker is_neo_adjuvant_to Andre Dekker is_when Andre Dekker is_treated_in Hospital or institute (range) where patient (domain) was treated. Andre Dekker associated_with has a significant or salient relationship to. has_person_identifier Andre Dekker conceptually_related_to Andre Dekker delineation_of Andre Dekker occurs_in Takes place in or happens under given conditions, circumstances, or time periods, or in a given location or population. This includes appears in, transpires, comes about, is present in, and exists in. Andre Dekker has_occurrence Andre Dekker functionally_related_to That part of a phenomenon which is directly observable or concretely or visibly expressed, or which gives evidence to the underlying process. This includes expression of, display of, and exhibition of. Andre Dekker has_organism_attribute Andre Dekker causes Andre Dekker brought_about_by Andre Dekker caused_by Andre Dekker spatially_related_to Andre Dekker location_of The position, site, or region of an entity or the site of a process. Andre Dekker has_location Andre Dekker indicates Gives evidence for the presence at some time of an entity or process. Andre Dekker indicated_by Andre Dekker uses Employs in the carrying out of some activity. This includes applies, utilizes, employs, and avails. Andre Dekker used_by Andre Dekker diagnoses Distinguishes or identifies the nature or characteristics of. Andre Dekker diagnosed_by Andre Dekker measures Ascertains or marks the dimensions, quantity, degree, or capacity of. Andre Dekker measured_by Andre Dekker property_of Characteristic of, or quality of. Andre Dekker has_property Andre Dekker measurement_of The dimension, quantity, or capacity determined by measuring. Andre Dekker has_measurement Andre Dekker degree_of Andre Dekker has_degree Andre Dekker uses_ACE_inhibitor Andre Dekker has_performance_status Andre Dekker has_AJCC_version Andre Dekker has_body_mass_index Andre Dekker has_body_part Andre Dekker has_chemo_timing Andre Dekker has_count Andre Dekker has_fraction_count Andre Dekker has_image_count Andre Dekker has_patient_count Andre Dekker has_count_pet_5g Andre Dekker has_date Andre Dekker has_alive_last_checked_date Andre Dekker method_of The manner and sequence of events in performing an act or procedure. Andre Dekker has_method Andre Dekker indicates Andre Dekker indicated_by Andre Dekker physically_related_to Andre Dekker part_of Composes, with one or more other physical units, some larger whole. This includes component of, division of, portion of, fragment of, section of, and layer of. Andre Dekker has_part Andre Dekker has_cause_of_death Andre Dekker has_chemo_start_date Andre Dekker has_clinical_m_stage Andre Dekker has_clinical_n_stage Andre Dekker has_clinical_stage Andre Dekker has_clinical_t_stage Andre Dekker has_cumulative_dose Andre Dekker has_body_height Andre Dekker has_body_weight Andre Dekker has_date_of_death Andre Dekker has_date_of_diagnosis Andre Dekker has_date_of_procedure Andre Dekker has_death Andre Dekker has_death_finding Andre Dekker has_comorbidity Andre Dekker has_disease_date Andre Dekker has_disease_finding Andre Dekker has_disease_qualifier Andre Dekker has_dose Andre Dekker has_duration Andre Dekker has_dysphagia Andre Dekker has_dyspnea Andre Dekker has_fev1_percentage Andre Dekker has_fev1_test Andre Dekker has_version Andre Dekker has_fraction_dose Andre Dekker has_fractionation_part Andre Dekker has_hypertension Andre Dekker has_life Andre Dekker has_marital_status Andre Dekker has_max_esophagus_dose Andre Dekker has_mean_esophagus_dose Andre Dekker has_mean_lung_dose Andre Dekker has_modality Andre Dekker has_nodal_tumor_volume Andre Dekker has_overall_duration Andre Dekker has_pacs_patient Andre Dekker has_pacs_series Andre Dekker has_pacs_study Andre Dekker has_pathological_m_stage Andre Dekker has_pathological_n_stage Andre Dekker has_pathological_stage Andre Dekker has_pathological_t_stage Andre Dekker has_patient_finding Andre Dekker has_patient_guid Andre Dekker has_primary_tumor_volume Andre Dekker has_procedure_date Andre Dekker has_procedure_duration Andre Dekker has_qualifier Andre Dekker has_rt_dose Andre Dekker has_rt_end_date Andre Dekker has_rt_start_date Andre Dekker has_radiation_therapy Andre Dekker has_secondary_neoplasm Andre Dekker has_series Andre Dekker has_series_guid Andre Dekker has_series_uid Andre Dekker has_smoking_status Andre Dekker has_study Andre Dekker has_study_guid Andre Dekker has_study_uid Andre Dekker has_surgical_procedure Andre Dekker has_survival_time Andre Dekker has_tumor_burden Andre Dekker has_tumor_volume Andre Dekker has_uid Andre Dekker has_volume Andre Dekker has_date_observed Andre Dekker has_id Andre Dekker has_birth Johan van Soest has_recurrence_status Johan van Soest has_recurrence_time Andre Dekker has_chemo_end_date Andre Dekker has_laterality Andre Dekker process_of Action, function, or state of. Andre Dekker has_process Andre Dekker manifestation_of Andre Dekker has_overall_stage Andre Dekker has_manifestation Andre Dekker result_of The condition, product, or state occurring as a consequence, effect, or conclusion of an activity or process. This includes product of, effect of, sequel of, outcome of, culmination of, and completion of. Andre Dekker has_result Andre Dekker affects Produces a direct effect on. Implied here is the altering or influencing of an existing condition, state, situation, or entity. This includes has a role in, alters, influences, predisposes, catalyzes, stimulates, regulates, depresses, impedes, enhances, contributes to, leads to, and modifies. Andre Dekker affected_by Andre Dekker manages Administers, or contributes to the care of an individual or group of individuals. Andre Dekker managed_by Andre Dekker treats Applies a remedy with the object of effecting a cure or managing a condition. Andre Dekker treated_by Andre Dekker complicates Causes to become more severe or complex or results in adverse effects. Andre Dekker complicated_by Andre Dekker prevents Stops, hinders or eliminates an action or condition. Andre Dekker prevented_by Andre Dekker disrupts Alters or influences an already existing condition, state, or situation. Produces a negative effect on. Andre Dekker disrupted_by Andre Dekker performs Executes, accomplishes, or achieves an activity. Andre Dekker performed_by Andre Dekker exhibits Shows or demonstrates. Andre Dekker exhibited_by Andre Dekker produces Brings forth, generates or creates. This includes yields, secretes, emits, biosynthesizes, generates, releases, discharges, and creates. Andre Dekker produced_by Andre Dekker practices Performs habitually or customarily. Andre Dekker practiced_by Andre Dekker interacts_with Andre Dekker carries_out Executes a function or performs a procedure or activity. This includes transacts, operates on, handles, and executes. Andre Dekker carried_out_by Andre Dekker contains Holds or is the receptacle for fluids or other substances. This includes is filled with, holds, and is occupied by. Andre Dekker contained_in Andre Dekker consists_of Is structurally made up of in whole or in part of some material or matter. This includes composed of, made of, and formed of. Andre Dekker connected_to Directly attached to another physical unit as tendons are connected to muscles. This includes attached to and anchored to. Andre Dekker interconnects Serves to link or join together two or more other physical units. This includes joins, links, conjoins, articulates, separates, and bridges. Andre Dekker branch_of Arises from the division of. For example, the arborization of arteries. Andre Dekker tributary_of Merges with. For example, the confluence of veins. Andre Dekker ingredient_of Is a component of, as in a constituent of a preparation. Andre Dekker has_ingredient Andre Dekker has_tributary Andre Dekker interconnected_by Andre Dekker constitutes Andre Dekker has_branch Andre Dekker adjacent_to Close to, near or abutting another physical unit with no other structure of the same kind intervening. This includes adjoins, abuts, is contiguous to, is juxtaposed, and is close to. Andre Dekker surrounds Establishes the boundaries for, or defines the limits of another physical structure. This includes limits, bounds, confines, encloses, and circumscribes. Andre Dekker surrounded_by Andre Dekker traverses Crosses or extends across another physical structure or area. This includes crosses over and crosses through. Andre Dekker traversed_by Andre Dekker conceptual_part_of Conceptually a portion, division, or component of some larger whole. Andre Dekker has_conceptual_part Andre Dekker evaluation_of Judgment of the value or degree of some attribute or process. Andre Dekker has_evaluation Andre Dekker assesses_effect_of Analyzes the influence or consequences of the function or action of. Andre Dekker assessed_for_effect_by Andre Dekker issue_in Is an issue in or a point of discussion, study, debate, or dispute. Andre Dekker has_issue Andre Dekker derivative_of In chemistry, a substance structurally related to another or that can be made from the other substance. This is used only for structural relationships. This does not include functional relationships such as metabolite of, by product of, nor analog of. Andre Dekker has_derivative Andre Dekker developmental_form_of An earlier stage in the individual maturation of. Andre Dekker has_developmental_form Andre Dekker analyzes Studies or examines using established quantitative or qualitative methods. Andre Dekker analyzed_by Andre Dekker at_date_time Andre Dekker has_value ncit:C101516 http://purl.bioontology.org/ontology/NCIT Palliative Any action or response, without curative intent, that mitigates some or all of the unpleasant effects of a disease or condition. ncit:C101642 http://purl.bioontology.org/ontology/NCIT Adjuvant Radiotherapy Radiation therapy that is administered to augment or stimulate other treatment modalities or to minimize or prevent disease recurrence. ncit:C102955 http://purl.bioontology.org/ontology/NCIT Great Blood Vessel Any of the major arteries or veins attached to the cardiac atria or ventricles. This includes the aorta, superior and inferior vena cava and the pulmonary arteries and veins. ncit:C103267 http://purl.bioontology.org/ontology/NCIT Narrow Surgical Margin An indication that a surgical margin is in close proximity to the excised tumor. ncit:C104933 http://purl.bioontology.org/ontology/NCIT Volume Modulated Arc Therapy Radiation therapy delivered to the whole volume of target tissue by a single rotation of the linear accelerator gantry. ncit:C104941 http://purl.bioontology.org/ontology/NCIT Scanning Proton Beam Therapy Proton beam radiation therapy in which magnets deflect and steer the proton beam. ncit:C104942 http://purl.bioontology.org/ontology/NCIT Scattering Proton Beam Therapy Proton beam radiation therapy in which the proton beam is spread by placing scattering material in the path of the protons. ncit:C105721 http://purl.bioontology.org/ontology/NCIT ECOG Performance Status EuroCAT Umbrella Protocol for NSCLC A performance status scale designed to assess disease progression and its affect on the daily living abilities of the patient. ncit:C105722 http://purl.bioontology.org/ontology/NCIT ECOG Performance Status 0 EuroCAT Umbrella Protocol for NSCLC Fully active, able to carry on all pre-disease performance without restriction. ncit:C105723 http://purl.bioontology.org/ontology/NCIT ECOG Performance Status 1 EuroCAT Umbrella Protocol for NSCLC Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work. ncit:C105725 http://purl.bioontology.org/ontology/NCIT ECOG Performance Status 2 EuroCAT Umbrella Protocol for NSCLC Ambulatory and capable of all self care but unable to carry out any work activities. Up and about more than 50% of waking hours. ncit:C105726 http://purl.bioontology.org/ontology/NCIT ECOG Performance Status 3 EuroCAT Umbrella Protocol for NSCLC Capable of only limited selfcare, confined to bed or chair more than 50% of waking hours. ncit:C105727 http://purl.bioontology.org/ontology/NCIT ECOG Performance Status 4 EuroCAT Umbrella Protocol for NSCLC Completely disabled. Cannot carry on any selfcare. Totally confined to bed or chair. ncit:C105728 http://purl.bioontology.org/ontology/NCIT ECOG Performance Status 5 EuroCAT Umbrella Protocol for NSCLC Dead. ncit:C106304 http://purl.bioontology.org/ontology/NCIT Tumor Regression Grade TRG A pathologic grading system used to evaluate the tumor response to preoperative chemotherapy and radiation. ncit:C11197 http://purl.bioontology.org/ontology/NCIT FOLFOX Regimen CF/5-FU/L-OHP Fluorouracil/Leucovorin Calcium/Oxaliplatin One of several chemotherapy regimens that include leucovorin calcium (calcium folinate), 5-fluorouracil and oxaliplatin and which may be used in the treatment of advanced-stage and metastatic colorectal cancer. FOLFOX regimens differ in agent dosing and administration schedule and include FOLFOX 4, FOLFOX 6, modified FOLFOX 6 (mFOLFOX 6) and FOLFOX 7. ncit:C112376 http://purl.bioontology.org/ontology/NCIT Percent Predicted Forced Expiratory Volume in 1 Second EuroCAT Umbrella Protocol for NSCLC Forced expiratory volume in one second as a proportion of the predicted normal value. (CDISC) ncit:C112816 http://purl.bioontology.org/ontology/NCIT Dose Volume Histogram A plot of a cumulative dose-volume frequency distribution that graphically summarizes the simulated radiation distribution within a volume of interest of a patient which would result from a proposed radiation treatment plan. ncit:C112913 http://purl.bioontology.org/ontology/NCIT Gross Target Volume The gross palpable or visible/demonstrable extent and location of malignant growth. ncit:C113716 http://purl.bioontology.org/ontology/NCIT Low Anterior Resection Resection of the rectum for cancer through an incision in the lower abdomen. ncit:C113730 http://purl.bioontology.org/ontology/NCIT Grade X GX A morphologic qualifier indicating that the grade of a neoplasm cannot be assessed. ncit:C116430 http://purl.bioontology.org/ontology/NCIT 4-Dimensional Conformal Radiation Therapy 3-Dimensional conformal radiation therapy that is designed to compensate for motion of the tumor and surrounding normal tissue during each treatment session. ncit:C116441 http://purl.bioontology.org/ontology/NCIT 4-Dimensional Computed Tomography 4DCT RC-CT Respiratory Correlated CT Computed tomography scans designed to minimize motion artifacts. 4DCT can be accomplished by collecting data for the duration of the patient's respiratory cycle and by oversampling CT data acquisition at each slice. ncit:C116509 http://purl.bioontology.org/ontology/NCIT Robot-Assisted Laparoscopic Surgery A surgical technique that uses a specially designed robotic system to aid with a laparoscopic surgical procedure. ncit:C1181 http://purl.bioontology.org/ontology/NCIT Oxaliplatin ncit:C118286 http://purl.bioontology.org/ontology/NCIT Stereotactic Body Radiation Therapy EuroCAT Umbrella Protocol for NSCLC SBRT Stereotactic radiation therapy in which one or several maximum dose radiation treatments are delivered targeting cancers of the body, excluding the brain or spine. ncit:C120274 http://purl.bioontology.org/ontology/NCIT Macroscopically Positive Surgical Margin The presence of macroscopically visible residual tumor at the edge of a surgically excised specimen. ncit:C120277 http://purl.bioontology.org/ontology/NCIT Grossly Negative and Microscopically Positive Surgical Margin The presence of microscopically visible residual tumor at the edge of a surgically excised specimen that otherwise looks macroscopically normal. ncit:C120284 Tumor Size The size of a tumor in its greatest dimension. ncit:C12218 http://purl.bioontology.org/ontology/NCIT Chemotherapy Regimen or Agent Combination A combination of multiple drugs used in standard or clinical trial treatments. The order, dosage or dosing interval of the individual ingredients may not be specified. ncit:C12253 http://purl.bioontology.org/ontology/NCIT Upper Third of the Esophagus Upper Esophagus The upper one third of esophagus in which the muscle layer is composed of muscle cells of the striated type. ncit:C12254 http://purl.bioontology.org/ontology/NCIT Middle Third of the Esophagus Middle Esophagus The middle one third of the esophagus in which the muscle layer is composed of muscle cells of the striated and smooth types. ncit:C12255 http://purl.bioontology.org/ontology/NCIT Lower Third of the Esophagus Lower Esophagus The lower one third of the esophagus in which the muscle layer is composed of muscle cells predominantly of the smooth type. ncit:C123603 http://purl.bioontology.org/ontology/NCIT Pathologic Complete Response Complete Pathological Response pCR The disappearance of all signs of cancer, supported by pathological examination. ncit:C12512 http://purl.bioontology.org/ontology/NCIT Supratentorial Brain The part of the brain above the tentorium cerebellum. (NCI) For most authors, this is the cerebral hemispheres plus the basal ganglia, but most clinicians do not include the basal ganglia. ncit:C125609 http://purl.bioontology.org/ontology/NCIT 4D PET Scan 4D Gated PET Scan Positron emission tomography imaging collected over time. It is designed to capture the internal movement of organs and the metabolism of the tumor. It creates the most complete and accurate information on the tumor and provides information how the tumor moves with breathing and other body motions. ncit:C1275 http://purl.bioontology.org/ontology/NCIT Vinorelbine EuroCAT Umbrella Protocol for NSCLC A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. ncit:C1282 http://purl.bioontology.org/ontology/NCIT Carboplatin EuroCAT Umbrella Protocol for NSCLC A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04) ncit:C1331 http://purl.bioontology.org/ontology/NCIT Epipodophyllotoxin Compound An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. ncit:C13345 http://purl.bioontology.org/ontology/NCIT Stoma A surgically created opening from an area inside the body to the outside. ncit:C136485 http://purl.bioontology.org/ontology/NCIT Stage IA3 A stage term referring to invasive lung cancer. It includes: T1c, N0, M0. T1c: Tumor measuring more than 2 cm but 3 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (adapted from AJCC) ncit:C1411 http://purl.bioontology.org/ontology/NCIT Paclitaxel EuroCAT Umbrella Protocol for NSCLC A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04) ncit:C141461 http://purl.bioontology.org/ontology/NCIT Occult Stage A stage term that refers to a cancer in which the primary site is unknown (not detectable by clinical or radiologic examination). The definition of occult stage depends on the particular type of cancer that it refers to; for example, for breast cancer, occult stage is defined as cancer presenting with axillary lymph node metastasis without a primary in the breast being found; for non-small cell lung carcinoma, occult stage is defined as cancer detectable by sputum cytology only and the primary tumor is undetectable radiographically or during bronchoscopy. ncit:C14151 http://purl.bioontology.org/ontology/NCIT Unresectable EuroCAT Umbrella Protocol for NSCLC Unable to be removed with surgery. ncit:C14162 http://purl.bioontology.org/ontology/NCIT Moderately Differentiated Describes tumor cells that have lost some of the appearance of normal cells. They tend to grow and spread at a faster rate than well differentiated tumor cells. ncit:C14167 http://purl.bioontology.org/ontology/NCIT Poorly Differentiated Describes tumor cells that generally have lost most of the appearance of normal cells. They tend to grow and spread. ncit:C14171 http://purl.bioontology.org/ontology/NCIT Well Differentiated Describes tumor cells that generally retain the appearance of normal cells and tend to grow and spread at a slower rate than undifferentiated or poorly differentiated tumor cells. ncit:C14284 http://purl.bioontology.org/ontology/NCIT Woman An adult, female human. ncit:C14366 http://purl.bioontology.org/ontology/NCIT Man An adult, male human. ncit:C1450 http://purl.bioontology.org/ontology/NCIT Platinum Compound A chemotherapy compound that contains a platinum atom. Platinum compounds do not contain alkyl groups but do cause DNA crosslinks and adducts similar to alkylating agents. DNA crosslinks and adducts ultimately lead to the induction of apoptosis. ncit:C1490 http://purl.bioontology.org/ontology/NCIT Taxane Compound A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer. A taxane is a type of mitotic inhibitor and a type of antimicrotubule agent. ncit:C15189 http://purl.bioontology.org/ontology/NCIT Biopsy The removal of tissue specimens or fluid from the living body for microscopic examination, performed to establish a diagnosis. ncit:C15212 http://purl.bioontology.org/ontology/NCIT Multimodality Therapy Use of two or more simultaneous or consecutive treatment modalities; e.g., surgery + radiation, or radiation + immunotherapy. Does not refer to use of two or more chemotherapeutic agents. ncit:C1526 http://purl.bioontology.org/ontology/NCIT Docetaxel EuroCAT Umbrella Protocol for NSCLC A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04) ncit:C15266 http://purl.bioontology.org/ontology/NCIT Laparotomy Creation of a surgical opening into the abdominal cavity. ncit:C15275 http://purl.bioontology.org/ontology/NCIT Lymphadenectomy Lymph Node Dissection Surgical removal of lymph nodes, usually done to assess the spread of cancer. ncit:C15305 http://purl.bioontology.org/ontology/NCIT Pneumonectomy EuroCAT Umbrella Protocol for NSCLC The excision of part or all of a lung. ncit:C15313 http://purl.bioontology.org/ontology/NCIT Radiation Therapy Treatment of a disease by means of exposure of the target or the whole body to radiation. Radiation therapy is often used as part of curative therapy and occasionally as a component of palliative treatment for cancer. Other uses include total body irradiation prior to transplantation. ncit:C15329 http://purl.bioontology.org/ontology/NCIT Surgical Procedure EuroCAT Umbrella Protocol for NSCLC A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery. ncit:C15358 http://purl.bioontology.org/ontology/NCIT Stereotactic Radiosurgery A non-surgical procedure that was developed to deliver one or several maximum dose targeted radiation treatments for cancers in the brain or spine. ncit:C15360 http://purl.bioontology.org/ontology/NCIT Adjuvant Chemotherapy Chemotherapy that is administered subsequent to the main treatment plan to minimize or prevent disease recurrence. ncit:C15382 http://purl.bioontology.org/ontology/NCIT Gamma Knife A treatment using gamma rays, a type of high-energy radiation that can be tightly focused on small tumors or other lesions in the head or neck, so very little normal tissue receives radiation. The gamma rays are aimed at the tumor from many different angles at once, and deliver a large dose of radiation exactly to the tumor in one treatment session. This procedure is a type of stereotactic radiosurgery. ncit:C15632 http://purl.bioontology.org/ontology/NCIT Chemotherapy EuroCAT Umbrella Protocol for NSCLC The use of synthetic or naturally-occurring chemicals for the treatment of diseases. ncit:C15654 http://purl.bioontology.org/ontology/NCIT Fractionation Dividing the total dose of radiation therapy into several smaller, equal doses delivered over a period of several days. ncit:C15655 http://purl.bioontology.org/ontology/NCIT Thoracic Surgical Procedure EuroCAT Umbrella Protocol for NSCLC Surgery performed on the thoracic organs, most commonly the lungs and the heart. ncit:C15665 http://purl.bioontology.org/ontology/NCIT Neoadjuvant Therapy Treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy. It is a type of induction therapy. ncit:C15675 http://purl.bioontology.org/ontology/NCIT Adjuvant Therapy Any therapy that is administered to augment or stimulate other treatment modalities or to minimize or prevent disease recurrence subsequent to the main treatment plan. ncit:C15688 http://purl.bioontology.org/ontology/NCIT Maintenance Therapy Continuation of treatment for an extended period of time to prevent relapse. ncit:C15697 http://purl.bioontology.org/ontology/NCIT Treatment Regimen EuroCAT Umbrella Protocol for NSCLC Treatment Protocol A treatment plan that specifies the dosage, the schedule, and the duration of treatment. ncit:C15725 http://purl.bioontology.org/ontology/NCIT Laparoscopic Surgery Surgery done with the aid of a laparoscope. A laparoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue to be checked under a microscope for signs of disease. ncit:C16033 http://purl.bioontology.org/ontology/NCIT Follow-up EuroCAT Umbrella Protocol for NSCLC The activity of monitoring a person's health over time after treatment. ncit:C16035 http://purl.bioontology.org/ontology/NCIT 3-Dimensional Conformal Radiation Therapy EuroCAT Umbrella Protocol for NSCLC 3D-CRT A process by which a dose of radiation is automatically shaped to closely conform to the entire volume of the tumor, so that surrounding normal tissue is spared and treatment toxicity is decreased. ncit:C16120 http://purl.bioontology.org/ontology/NCIT Abdominal Surgical Procedure Surgery performed on any part of the abdominal region of the body. ncit:C16135 http://purl.bioontology.org/ontology/NCIT Intensity-Modulated Radiation Therapy EuroCAT Umbrella Protocol for NSCLC IMRT An advanced form of 3-Dimensional Conformal Radiation Therapy (3D CRT) that involves the use of varying intensities of small radiation beams to produce dosage distributions that are more precise than those possible with 3D CRT. ncit:C16180 http://purl.bioontology.org/ontology/NCIT Total Mesorectal Excision TME Surgery for rectal cancer involving precise removal of an intact mesorectal envelope with tumor-free margins. Associated with local recurrence rates below 5% in clinical trials. ncit:C16358 http://purl.bioontology.org/ontology/NCIT Body Mass Index A general indicator of the body fat an individual is carrying based upon the ratio of weight to height. ncit:C16457 http://purl.bioontology.org/ontology/NCIT Comorbidity EuroCAT Umbrella Protocol for NSCLC The coexistence of two or more disease processes. ncit:C16493 http://purl.bioontology.org/ontology/NCIT Data Source The person or authoritative body who provided the information. ncit:C16576 http://purl.bioontology.org/ontology/NCIT Female EuroCAT Umbrella Protocol for NSCLC A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both. ncit:C16809 http://purl.bioontology.org/ontology/NCIT Magnetic Resonance Imaging Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide amazingly clear and detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders. ncit:C16960 http://purl.bioontology.org/ontology/NCIT Patient A person who receives medical attention, care, or treatment, or who is registered with medical professional or institution with the purpose to receive medical care when necessary. ncit:C17007 http://purl.bioontology.org/ontology/NCIT Positron Emission Tomography PET Scan A technique for measuring the gamma radiation produced by collisions of electrons and positrons (anti-electrons) within living tissue. In positron emission tomography (PET), a subject is given a dose of a positron-emitting radionuclide attached to a metabolically active substance (for example, 2-fluoro-2-deoxy-D-glucose (FDG), which is similar to a naturally occurring sugar, glucose, with the addition of a radioactive fluorine atom). When living tissue containing the positron emitter is bombarded by electrons, gamma radiation produced by collisions of electrons and positrons is detected by a scanner, revealing in fine detail the tissue location of the metabolically-active substance administered. ncit:C17204 http://purl.bioontology.org/ontology/NCIT Computed Tomography A method of examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis. ncit:C1723 http://purl.bioontology.org/ontology/NCIT Cetuximab EuroCAT Umbrella Protocol for NSCLC A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors. ncit:C17357 http://purl.bioontology.org/ontology/NCIT Gender The assemblage of properties that distinguish people on the basis of the societal roles expected for the two sexes. ncit:C17427 http://purl.bioontology.org/ontology/NCIT Smoking Cessation EuroCAT Umbrella Protocol for NSCLC nicotine_stop Discontinuation of the habit of smoking. ncit:C17610 http://purl.bioontology.org/ontology/NCIT Blood Sample EuroCAT Umbrella Protocol for NSCLC A small volume of blood removed for testing or storage. ncit:C1794 http://purl.bioontology.org/ontology/NCIT Capecitabine Xeloda ncit:C18000 http://purl.bioontology.org/ontology/NCIT Histologic Grade The degree of abnormality of cancer cells, a measure of differentiation, the extent to which cancer cells are similar in appearance and function to healthy cells of the same tissue type. The degree of differentiation often relates to the clinical behavior of the particular tumor. Based on the microscopic findings, tumor grade is commonly described by one of four degrees of severity. Histopathologic grade of a tumor may be used to plan treatment and estimate the future course, outcome, and overall prognosis of disease. Certain types of cancers, such as soft tissue sarcoma, primary brain tumors, lymphomas, and breast have special grading systems. ncit:C18009 http://purl.bioontology.org/ontology/NCIT Tumor Tissue EuroCAT Umbrella Protocol for NSCLC A tumor sample, or entire tumor that is removed for microscopic examination. ncit:C18020 http://purl.bioontology.org/ontology/NCIT Diagnostic Procedure Any procedure or test to diagnose a disease or disorder. ncit:C1804 http://purl.bioontology.org/ontology/NCIT Raltitrexed Tomudex An anticancer drug that stops tumor cells from growing by blocking the ability of cells to make DNA. It belongs to the family of drugs called thymidylate synthase inhibitors. ncit:C1820 http://purl.bioontology.org/ontology/NCIT Mitomycin Mitomycin-C A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. ncit:C19326 http://purl.bioontology.org/ontology/NCIT Clinics and Hospitals EuroCAT Umbrella Protocol for NSCLC Institute Institutions with an organized medical staff for the medical care, treatment, and cure of the sick and wounded, for the study of disease, and for the training of physicians, nurses, and allied health personnel. ncit:C19697 http://purl.bioontology.org/ontology/NCIT Tissue Sample A piece of tissue removed from an organism for examination, analysis, or propagation. ncit:C19796 http://purl.bioontology.org/ontology/NCIT Smoking Status EuroCAT Umbrella Protocol for NSCLC An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history. ncit:C20188 http://purl.bioontology.org/ontology/NCIT Social Circumstances A set of concepts that results from or is influenced by criteria or activities associated with the social environment of a person. ncit:C20197 http://purl.bioontology.org/ontology/NCIT Male EuroCAT Umbrella Protocol for NSCLC A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. ncit:C20200 http://purl.bioontology.org/ontology/NCIT Outcome The result of an action. ncit:C2039 http://purl.bioontology.org/ontology/NCIT Bevacizumab EuroCAT Umbrella Protocol for NSCLC A recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine. Bevacizumab binds to VEGF and inhibits VEGF receptor binding, thereby preventing the growth and maintenance of tumor blood vessels. ncit:C20641 http://purl.bioontology.org/ontology/NCIT Performance Status A measure of how well a patient is able to perform ordinary tasks and carry out daily activities. ncit:C21514 http://purl.bioontology.org/ontology/NCIT Temporal Qualifier Terms used to indicate units of time or other terms associated with time. ncit:C247 http://purl.bioontology.org/ontology/NCIT ACE Inhibitor Any substance that inhibits angiotensin-converting enzyme (ACE), an enzyme that catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis. ncit:C25150 http://purl.bioontology.org/ontology/NCIT Age How long something has existed; elapsed time since birth. ncit:C25155 http://purl.bioontology.org/ontology/NCIT Birth The event of being born. ncit:C25164 http://purl.bioontology.org/ontology/NCIT Date The particular day, month and year an event has happened or will happen. ncit:C25185 http://purl.bioontology.org/ontology/NCIT Laterality Dominant use or manifestations of one side of the body versus the other; referring to a side of the body or of a structure. ncit:C25188 http://purl.bioontology.org/ontology/NCIT Marital Status EuroCAT Umbrella Protocol for NSCLC A demographic parameter indicating a person's current conjugal status. ncit:C25190 http://purl.bioontology.org/ontology/NCIT Person A human being. ncit:C25208 Weight The vertical force exerted by a mass as a result of gravity. ncit:C25218 http://purl.bioontology.org/ontology/NCIT Intervention or Procedure An activity that produces an effect, or that is intended to alter the course of a disease in a patient or population. This is a general term that encompasses the medical, social, behavioral, and environmental acts that can have preventive, therapeutic, or palliative effects. ncit:C25228 http://purl.bioontology.org/ontology/NCIT Right Being or located on or directed toward the side of the body to the east when facing north. ncit:C25229 http://purl.bioontology.org/ontology/NCIT Left Being or located on or directed toward the side of the body to the west when facing north. ncit:C25330 http://purl.bioontology.org/ontology/NCIT Duration The period of time during which something continues. ncit:C25334 http://purl.bioontology.org/ontology/NCIT Length The linear extent in space from one end of something to the other end, or the extent of something from beginning to end. ncit:C25335 http://purl.bioontology.org/ontology/NCIT Volume The amount of three dimensional space occupied by an object or the capacity of a space or container. ncit:C25347 http://purl.bioontology.org/ontology/NCIT Height The vertical measurement or distance from the base to the top of an object; the vertical dimension of extension. ncit:C25364 http://purl.bioontology.org/ontology/NCIT Identifier One or more characters used to identify, name, or characterize the nature, properties, or contents of a thing. ncit:C25400 http://purl.bioontology.org/ontology/NCIT Zubrod Performance Status A scale used to assess how a patient's disease is progressing and assess how the disease affects the daily living abilities of the patient. ncit:C25419 http://purl.bioontology.org/ontology/NCIT Anal Margin Anal Verge The transitional zone between the moist, hairless, modified skin of the anal canal and the perianal skin. ncit:C25463 http://purl.bioontology.org/ontology/NCIT Count To determine the number or amount of something; the result of this activity. ncit:C25488 http://purl.bioontology.org/ontology/NCIT Dose A quantity of an agent (such as substance or energy) administered, taken, or absorbed at one time. ncit:C25514 http://purl.bioontology.org/ontology/NCIT Fraction A part, a fragment of a whole. ncit:C25563 http://purl.bioontology.org/ontology/NCIT Margin A boundary line or the area immediately inside the boundary. ncit:C25613 http://purl.bioontology.org/ontology/NCIT Percentage A fraction or ratio with 100 understood as the denominator. ncit:C25621 http://purl.bioontology.org/ontology/NCIT Postal Code Any system designed to expedite the sorting and delivery of mail by assigning a series of alphanumeric codes to each delivery area. Also used to refer to any individual delivery area code. ncit:C25653 http://purl.bioontology.org/ontology/NCIT Resectable EuroCAT Umbrella Protocol for NSCLC Capable of being removed by surgery. ncit:C25681 Size The physical magnitude of something. ncit:C25714 http://purl.bioontology.org/ontology/NCIT Version A form or variant of a type or original; one of a sequence of copies of a program, each incorporating new modifications. ncit:C25717 http://purl.bioontology.org/ontology/NCIT Vital Status EuroCAT Umbrella Protocol for NSCLC The state or condition of being living or deceased; also includes the case where the vital status is unknown. ncit:C25725 http://purl.bioontology.org/ontology/NCIT Intent EuroCAT Umbrella Protocol for NSCLC An anticipated outcome that is the purpose for actions taken, thus guiding the action. ncit:C26871 http://purl.bioontology.org/ontology/NCIT Respiratory System Disorder EuroCAT Umbrella Protocol for NSCLC A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma. ncit:C27672 http://purl.bioontology.org/ontology/NCIT Non-Neoplastic Cardiovascular Disorder A non-neoplastic disorder that affects the heart and/or vessels. Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema. ncit:C27966 http://purl.bioontology.org/ontology/NCIT Stage I EuroCAT Umbrella Protocol for NSCLC Invasive cancer confined to the original anatomic site of growth without lymph node involvement. ncit:C27967 http://purl.bioontology.org/ontology/NCIT Stage IIA Invasive cancer more extensive than stage I, usually involving local lymph nodes without spread to distant anatomic sites. The definition of stage IIA depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIA is defined as follows: (T0, N1, M0); (T1, N1, M0); (T2, N0, M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension. N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s). N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IIA is defined as follows: T1, N0, M0, G3, G4. T1: Tumor 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G3: Poorly differentiated. G4: Undifferentiated. (partially adapted from AJCC 7th ed.) ncit:C27968 http://purl.bioontology.org/ontology/NCIT Stage IIB Invasive cancer more extensive than stage I, usually involving local lymph nodes without spread to distant anatomic sites. The definition of stage IIB depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIB is defined as follows: (T2, N1, MO); (T3, NO, MO). T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension. T3: Tumor more than 50 mm in greatest dimension. N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s). N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IIB is defined as follows: T2, N0, M0, G3, G4. T2: Tumor more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G3: Poorly differentiated. G4: Undifferentiated. (partially adapted from AJCC 7th ed.) ncit:C27970 http://purl.bioontology.org/ontology/NCIT Stage III EuroCAT Umbrella Protocol for NSCLC Locally advanced cancer that has spread to nearby organs but not to distant anatomic sites. ncit:C27971 http://purl.bioontology.org/ontology/NCIT Stage IV EuroCAT Umbrella Protocol for NSCLC Cancer that has spread to distant anatomic sites beyond its original site of growth. ncit:C27975 http://purl.bioontology.org/ontology/NCIT Stage IA Invasive cancer confined to the original anatomic site of growth without lymph node involvement. The definition of stage IA depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IA is defined as follows: T1, N0, M0. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IA is defined as follows: T1, N0, M0, G1, GX. T1: Tumor 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well differentiated-low grade. GX: Grade cannot be assessed. (partially adapted from AJCC 8th ed.) ncit:C27976 http://purl.bioontology.org/ontology/NCIT Stage IB Invasive cancer confined to the original anatomic site of growth without lymph node involvement. The definition of stage IB depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IB is defined as follows: (T0, N1mi, M0); (T1, N1mi, M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. N1mi: Nodal micrometastases. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IB is defined as follows: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX). T2: Tumor more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well differentiated-low grade. G2: Moderately differentiated-low grade. GX: Grade cannot be assessed. (partially adapted from AJCC 7th ed.) ncit:C27977 http://purl.bioontology.org/ontology/NCIT Stage IIIA EuroCAT Umbrella Protocol for NSCLC Locally advanced cancer that has spread to nearby organs but not to distant anatomic sites. The definition of stage IIIA depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIIA is defined as follows: (T0, N2, M0); (T1, N2, M0); (T2, N2, M0); (T3, N1, M0); (T3, N2, M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension. T3: Tumor more than 50 mm in greatest dimension. N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s). N2: Metastases in ipsilateral level I, II axillary lymph nodes that are clinically fixed or matted; or in clinically detected ipsilateral internal mammary nodes in the absence of clinically evident axillary lymph node metastases. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for cervical cancer, stage IIIA is defined as follows: T3a, N0, M0. T3a: Tumor involves lower third of vagina, no extension to pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (partially adapted from AJCC 7th ed.) ncit:C27978 http://purl.bioontology.org/ontology/NCIT Stage IIIB EuroCAT Umbrella Protocol for NSCLC Locally advanced cancer that has spread to nearby organs but not to distant anatomic sites. The definition of stage IIIB depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIIB is defined as follows: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0). T4: Tumor of any size with direct extension to the chest wall and/or to the skin (ulceration or skin nodules). N0: No regional lymph node metastasis. N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s). N2: Metastases in ipsilateral level I, II axillary lymph nodes that are clinically fixed or matted; or in clinically detected ipsilateral internal mammary nodes in the absence of clinically evident axillary lymph node metastases. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for cervical cancer, stage IIIB is defined as follows: (T3b, Any N, M0); (T1-3, N1, M0). T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (partially adapted from AJCC 7th ed.) ncit:C27979 http://purl.bioontology.org/ontology/NCIT Stage IVA Cancer that has spread to distant anatomic sites beyond its original site of growth. The definition of stage IVA depends on the particular type of cancer that it refers to; for example, for bone cancer, stage IVA is defined as follows: Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Distant metastasis to lung; for vaginal cancer, stage IVA is defined as follows: T4, Any N, M0. T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4). M0: No distant metastasis. (partially adapted from AJCC 7th ed.) ncit:C27980 http://purl.bioontology.org/ontology/NCIT Stage IVB Cancer that has spread to distant anatomic sites beyond its original site of growth. The definition of stage IVB depends on the particular type of cancer that it refers to; for example, for bone cancer, stage IVB is defined as follows: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N1: Regional lymph node metastasis. M1b: Metastasis to other distant sites; for vaginal cancer, stage IVB is defined as follows: Any T, Any N, M1. M1: Distant metastasis. (partially adapted from AJCC 7th ed.) ncit:C27982 http://purl.bioontology.org/ontology/NCIT Stage IIIC Locally advanced cancer that has spread to nearby organs but not to distant anatomic sites. The definition of stage IIIC depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIIC is defined as follows: Any T, N3, M0. N3: Metastases in ipsilateral infraclavicular (level III) axillary lymph nodes(s) with or without level I, II axillary lymph node involvement; or in clinically detected ipsilateral internal mammary lymph node(s) with clinically evident level I, II axillary lymph node metastases; or metastases in ipsilateral supraclavicular lymph node(s) with or without axillary or internal mammary lymph node involvement. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for appendix carcinoma, stage IIIC is defined as follows: Any T, N2, M0. N2: Metastasis in four or more regional lymph nodes. M0: No distant metastasis. (partially adapted from AJCC 7th ed.) ncit:C27983 http://purl.bioontology.org/ontology/NCIT Stage IA1 A stage term referring to invasive cervical and lung cancer. For cervical cancer, it includes: T1a1, N0, M0. T1a1: Tumor with stromal invasion 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. N0: No regional lymph node metastasis. M0: No distant metastasis. For lung cancer, it includes: (T1mi, N0, M0); (T1a, N0, M0). T1mi: Minimally invasive adenocarcinoma: adenocarcinoma (3 cm or less in greatest dimension) with a predominantly lepidic pattern and 5 mm or less invasion in greatest dimension. T1a: Tumor measuring 1 cm or less in greatest dimension. A superficial, spreading tumor of any size whose invasive component is limited to the bronchial wall and may extend proximal to the main bronchus also is classified as T1a, but these tumors are uncommon. N0: No regional lymph node metastasis. M0: No distant metastasis. (adapted from AJCC) ncit:C27984 http://purl.bioontology.org/ontology/NCIT Stage IA2 A stage term referring to invasive cervical cancer and invasive lung cancer. For cervical cancer, it includes: T1a2, N0, M0. T1a2: Tumor with stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. For lung cancer, it includes: T1b, N0, M0. T1b: Tumor measuring more than 1 cm but 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (adapted from AJCC) ncit:C28051 http://purl.bioontology.org/ontology/NCIT Stage 0 Cancer confined to the epithelium without invasion of the basement membrane. ncit:C28054 http://purl.bioontology.org/ontology/NCIT Stage II EuroCAT Umbrella Protocol for NSCLC Invasive cancer more extensive than stage I, usually involving local lymph nodes without spread to distant anatomic sites. ncit:C28076 http://purl.bioontology.org/ontology/NCIT Disease Grade Qualifier A term that refers to the cellular differentiation of a malignant cellular infiltrate. A cancer is defined through grades I-IV (or 1-4), or as well, moderately, poorly differentiated or undifferentiated. ncit:C28077 http://purl.bioontology.org/ontology/NCIT Grade 1 G1 A morphologic qualifier indicating that a cancerous lesion is well differentiated. ncit:C28078 http://purl.bioontology.org/ontology/NCIT Grade 2 G2 A morphologic qualifier indicating that a cancerous lesion is moderately differentiated. ncit:C28079 http://purl.bioontology.org/ontology/NCIT Grade 3 G3 A morphologic qualifier indicating that a cancerous lesion is poorly differentiated. ncit:C28082 http://purl.bioontology.org/ontology/NCIT Grade 4 G4 A morphologic qualifier indicating that a cancerous lesion is undifferentiated. ncit:C28103 http://purl.bioontology.org/ontology/NCIT Disease Treatment Qualifier EuroCAT Umbrella Protocol for NSCLC ncit:C28108 http://purl.bioontology.org/ontology/NCIT Disease Stage Qualifier EuroCAT Umbrella Protocol for NSCLC ncit:C28384 http://purl.bioontology.org/ontology/NCIT Tumor Burden The total volume of all macroscopic tumor tumors in the body. It is the sum of the primary tumor, macroscopic lymph nodes metastases and distant metastases. ncit:C28421 http://purl.bioontology.org/ontology/NCIT Sex EuroCAT Umbrella Protocol for NSCLC The assemblage of physical properties or qualities by which male is distinguished from female; the physical difference between male and female; the distinguishing peculiarity of male or female. ncit:C2852 http://purl.bioontology.org/ontology/NCIT Adenocarcinoma EuroCAT Umbrella Protocol for NSCLC A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. ncit:C28554 http://purl.bioontology.org/ontology/NCIT Death EuroCAT Umbrella Protocol for NSCLC The absence of life or state of being dead. (NCI) ncit:C2926 http://purl.bioontology.org/ontology/NCIT Non-Small Cell Lung Carcinoma A group of at least three distinct histological types of lung cancer, including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy. ncit:C2929 http://purl.bioontology.org/ontology/NCIT Squamous Cell Carcinoma EuroCAT Umbrella Protocol for NSCLC A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma. ncit:C2931 http://purl.bioontology.org/ontology/NCIT Cardiovascular Disorder EuroCAT Umbrella Protocol for NSCLC A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels). Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension. Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma. ncit:C2985 http://purl.bioontology.org/ontology/NCIT Diabetes Mellitus EuroCAT Umbrella Protocol for NSCLC A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization. ncit:C2991 http://purl.bioontology.org/ontology/NCIT Disease or Disorder Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. ncit:C3009 http://purl.bioontology.org/ontology/NCIT Endocrine System Disorder A non-neoplastic or neoplastic disorder that affects the endocrine system. Representative examples of non-neoplastic disorders include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency. Representative examples of neoplastic disorders include carcinoid tumor, neuroendocrine carcinoma, and pheochromocytoma. ncit:C3079 http://purl.bioontology.org/ontology/NCIT Heart Disorder A non-neoplastic or neoplastic disorder that affects the heart and/or the pericardium. Representative examples include endocarditis, pericarditis, atrial myxoma, cardiac myeloid sarcoma, and pericardial malignant mesothelioma. ncit:C3262 http://purl.bioontology.org/ontology/NCIT Neoplasm EuroCAT Umbrella Protocol for NSCLC A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. ncit:C3367 http://purl.bioontology.org/ontology/NCIT Finding Clinical, laboratory or molecular evidence, or absence of evidence of disease. ncit:C3445 http://purl.bioontology.org/ontology/NCIT Weight Loss EuroCAT Umbrella Protocol for NSCLC A reduction in total body weight. ncit:C35755 http://purl.bioontology.org/ontology/NCIT Non-Neoplastic Respiratory Disorder A non-neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis. ncit:C3577 http://purl.bioontology.org/ontology/NCIT Metastatic Malignant Neoplasm in the Lung Lung Metastasis The spread of a malignant neoplasm to the lung. This may be from a primary lung malignant neoplasm, or from a malignant neoplasm at a distant site. ncit:C3580 http://purl.bioontology.org/ontology/NCIT Metastatic Malignant Neoplasm in the Bone Bone Metastasis The spread of a malignant neoplasm from a primary site to the skeletal system. The majority of metastatic neoplasms to the bone are carcinomas. ncit:C35933 http://purl.bioontology.org/ontology/NCIT Distantly Metastatic Malignant Neoplasm Distant Metastasis A malignant tumor that has spread from its original (primary) site of growth to another site distant from the primary site. ncit:C35934 http://purl.bioontology.org/ontology/NCIT Locally Metastatic Malignant Neoplasm Regional Cancer Refers to cancer that has grown beyond the original (primary) tumor to nearby lymph nodes or organs and tissues. ncit:C36255 http://purl.bioontology.org/ontology/NCIT Secondary Neoplasm A neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment. ncit:C36263 http://purl.bioontology.org/ontology/NCIT Metastatic Malignant Neoplasm Metastasis A malignant tumor that has spread from its original (primary) site of growth to another site close to or distant from the primary site. ncit:C376 http://purl.bioontology.org/ontology/NCIT Cisplatin EuroCAT Umbrella Protocol for NSCLC An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. ncit:C3780 http://purl.bioontology.org/ontology/NCIT Large Cell Carcinoma EuroCAT Umbrella Protocol for NSCLC A malignant epithelial neoplasm composed of large, atypical cells. ncit:C37901 http://purl.bioontology.org/ontology/NCIT Site A position in relation to its surroundings. ncit:C37987 http://purl.bioontology.org/ontology/NCIT Life EuroCAT Umbrella Protocol for NSCLC The organic phenomenon that distinguishes living organisms from nonliving ones; showing characteristics of life. ncit:C38081 http://purl.bioontology.org/ontology/NCIT Pulmonary Function Test A broad range of tests that are performed to assess how well lungs inhale and exhale air and how efficiently they transfer oxygen into the blood. ncit:C38083 http://purl.bioontology.org/ontology/NCIT Carbon Monoxide Diffusing Capability Test EuroCAT Umbrella Protocol for NSCLC DLCO A measurement of carbon monoxide (CO) transfer from inspired gas to pulmonary capillary blood. During the test, the subject inspires a gas containing CO and one or more tracer gases to allow determination of the gas exchanging capability of the lungs. ncit:C38084 http://purl.bioontology.org/ontology/NCIT Forced Expiratory Volume in 1 Second EuroCAT Umbrella Protocol for NSCLC A test of lung function, the FEV1 is the volume exhaled during the first second of a forced expiratory maneuver started from the level of total lung capacity. It is the most frequently used index for assessing bronchoconstriction or bronchodilatation. ncit:C3813 http://purl.bioontology.org/ontology/NCIT Metastatic Malignant Neoplasm in the Brain Brain Metastasis A malignant neoplasm that has spread to the brain from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas). ncit:C38155 http://purl.bioontology.org/ontology/NCIT Recurrent Disease The return of a disease after a period of remission. ncit:C3910 http://purl.bioontology.org/ontology/NCIT Molecular Abnormality EuroCAT Umbrella Protocol for NSCLC A molecular or cytogenic abnormality which occurs in either human disease states or disease models. ncit:C3915 http://purl.bioontology.org/ontology/NCIT Small Cell Carcinoma EuroCAT Umbrella Protocol for NSCLC A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble "oat cells" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early. ncit:C40413 http://purl.bioontology.org/ontology/NCIT No Evidence of Disease Diagnostic tests fail to detect presence of disease. ncit:C40430 http://purl.bioontology.org/ontology/NCIT BRAF Gene Mutation EuroCAT Umbrella Protocol for NSCLC ncit:C405 http://purl.bioontology.org/ontology/NCIT Cyclophosphamide EuroCAT Umbrella Protocol for NSCLC A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. ncit:C41009 http://purl.bioontology.org/ontology/NCIT Qualifier A term that helps define and render a concept unique. ncit:C41227 http://purl.bioontology.org/ontology/NCIT Surgical Margin One of the criteria for assessment of the effectiveness of given surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. It is defined by the tissue plane through which the dissection has been done and the actual or potential neoplastic tissue which has been left outside the boundary of a resected specimen within the patient. There are four types of surgical margins: intracapsular or intralesional, marginal, wide, and radical. ncit:C41331 http://purl.bioontology.org/ontology/NCIT Adverse Event Any unfavorable or unintended symptom, sign, or disease including an abnormal laboratory finding) temporally associated with the use of a medical treatment or procedure that may or may not be considered related to the medical treatment or procedure. Such events can be intervention related, dose related, route related, patient related, or caused by an interaction with another drug(s) or procedure(s). ncit:C41361 http://purl.bioontology.org/ontology/NCIT KRAS Gene Mutation EuroCAT Umbrella Protocol for NSCLC ncit:C45313 http://purl.bioontology.org/ontology/NCIT Part One of the portions into which something is regarded as divided and which together constitute a whole. ncit:C456 http://purl.bioontology.org/ontology/NCIT Doxorubicin EuroCAT Umbrella Protocol for NSCLC An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects. ncit:C46085 http://purl.bioontology.org/ontology/NCIT Circumferential Resection Margin The distance between the radial extent of the tumor and the surgical incision used to excise the tumor. This distance is measured microscopically. ncit:C46109 http://purl.bioontology.org/ontology/NCIT Male Gender An individual who reports belonging to the cultural gender role distinction of male. ncit:C46110 http://purl.bioontology.org/ontology/NCIT Female Gender An individual who reports belonging to the cultural gender role distinction of female. ncit:C4741 http://purl.bioontology.org/ontology/NCIT Neoplasm by Morphology EuroCAT Umbrella Protocol for NSCLC A classification system grouping neoplasms according to their cellular characteristics. ncit:C4758 http://purl.bioontology.org/ontology/NCIT Metastatic Malignant Neoplasm in the Liver Liver Metastasis A malignant neoplasm that has spread to the liver from another (primary) anatomic site. Such malignant neoplasms may be carcinomas, lymphomas, melanomas, or sarcomas. ncit:C47850 http://purl.bioontology.org/ontology/NCIT Lymphatic Invasion A term referring to the presence of tumor emboli or tumor masses within lymphatic vessels. ncit:C48232 http://purl.bioontology.org/ontology/NCIT Cancer TNM Finding EuroCAT Umbrella Protocol for NSCLC A cancer finding in the TNM system that is relevant to the diagnosis of cancer. ncit:C48558 http://purl.bioontology.org/ontology/NCIT No Evidence of Metastatic Disease Diagnostic tests fail to detect presence of metastatic lesions. ncit:C48620 http://purl.bioontology.org/ontology/NCIT Positive Surgical Margin Indicates the presence of tumor cells at the edge of a surgically excised specimen. ncit:C48621 http://purl.bioontology.org/ontology/NCIT Negative Surgical Margin Indicates the absence of tumor cells at the edge of a surgically excised specimen. ncit:C48699 http://purl.bioontology.org/ontology/NCIT M0 Stage Finding EuroCAT Umbrella Protocol for NSCLC A distant metastasis TNM finding indicating that there is no evidence of distant metastasis. ncit:C48700 http://purl.bioontology.org/ontology/NCIT M1 Stage Finding EuroCAT Umbrella Protocol for NSCLC A clinical and/or pathologic distant metastasis TNM finding indicating the spread of cancer to distant anatomic sites. ncit:C48701 http://purl.bioontology.org/ontology/NCIT M1a Stage Finding A TNM finding indicating the spread of cancer to distant anatomic sites. The definition of M1a TNM finding depends on the specific type of cancer that it refers to; for example, for colorectal cancer it refers to metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node); for prostate cancer it refers to metastasis to non-regional lymph node(s); for bone cancer it refers to metastasis to the lung. ncit:C48702 http://purl.bioontology.org/ontology/NCIT M1b Stage Finding A TNM finding indicating the spread of cancer to distant anatomic sites. The definition of M1b TNM finding depends on the specific type of cancer that it refers to; for example, for colorectal cancer it refers to metastases in more than one organ/site or the peritoneum; for prostate cancer it refers to metastasis to bone(s); for bone cancer it refers to metastasis to distant sites other than lung. ncit:C48703 http://purl.bioontology.org/ontology/NCIT M1c Stage Finding A TNM finding indicating the spread of cancer to distant anatomic sites. The definition of M1c TNM finding depends on the specific type of cancer that it refers to; for example, for prostate cancer it refers to metastasis to anatomic site(s) other than bone, with or without bone disease; for retinoblastoma it refers to central nervous system metastasis; for melanoma of the uvea it refers to distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more. ncit:C48704 http://purl.bioontology.org/ontology/NCIT MX Stage Finding A distant metastasis TNM finding indicating that the status of distant metastasis cannot be assessed. ncit:C48705 http://purl.bioontology.org/ontology/NCIT N0 Stage Finding EuroCAT Umbrella Protocol for NSCLC A regional lymph node TNM finding indicating that there is no evidence of regional lymph node metastasis. ncit:C48706 http://purl.bioontology.org/ontology/NCIT N1 Stage Finding EuroCAT Umbrella Protocol for NSCLC A general term that refers to a TNM finding of cancer metastases usually in a limited number of regional lymph nodes. The definition of N1 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to micrometastases or metastases in 1-3 axillary lymph nodes; for cutaneous melanoma it refers to metastasis in 1 regional lymph node; for colorectal cancer it refers to metastases in 1-3 regional lymph nodes; and for bladder cancer it refers to metastasis in 1 regional lymph node in the true pelvis. ncit:C48714 http://purl.bioontology.org/ontology/NCIT N3 Stage Finding EuroCAT Umbrella Protocol for NSCLC A general term that refers to a TNM finding of cancer metastases in multiple lymph nodes. The definition of N3 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 10 or more axillary lymph nodes; for cutaneous melanoma it refers to metastases in 4 or more regional lymph nodes; for gastric cancer it refers to metastases in 7 or more regional lymph nodes; and for bladder cancer it refers to metastases in common iliac lymph nodes. ncit:C48718 http://purl.bioontology.org/ontology/NCIT NX Stage Finding EuroCAT Umbrella Protocol for NSCLC A regional lymph node TNM finding indicating that the status of regional lymph nodes cannot be assessed. ncit:C48719 http://purl.bioontology.org/ontology/NCIT T0 Stage Finding EuroCAT Umbrella Protocol for NSCLC A primary tumor TNM finding indicating that there is no evidence of primary tumor. ncit:C48720 http://purl.bioontology.org/ontology/NCIT T1 Stage Finding EuroCAT Umbrella Protocol for NSCLC A clinical and/or pathologic primary tumor TNM finding indicating that the cancer is limited to the site of growth. ncit:C48721 http://purl.bioontology.org/ontology/NCIT T1a Stage Finding EuroCAT Umbrella Protocol for NSCLC A general term that refers to a TNM finding of a primary tumor limited to the site of growth. The definition of T1a TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that is more than 0.1cm, but not more than 0.5 cm in greatest dimension; for kidney cancer it refers to a primary tumor that is 4 cm or less in greatest dimension; and for thyroid cancer it refers to a primary tumor that is 1 cm or less in greatest dimension. ncit:C48722 http://purl.bioontology.org/ontology/NCIT T1b Stage Finding EuroCAT Umbrella Protocol for NSCLC A general term that refers to a TNM finding of a primary tumor limited to the site of growth. The definition of T1b TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that is more than 0.5 cm, but not more than 1.0 cm in greatest dimension; for kidney cancer it refers to a primary tumor that is more than 4 cm, but not more than 7 cm in greatest dimension; and for thyroid cancer it refers to a primary tumor that is more than 1 cm but not more than 2 cm in greatest dimension. ncit:C48723 http://purl.bioontology.org/ontology/NCIT T1c Stage Finding EuroCAT Umbrella Protocol for NSCLC A general term that refers to a TNM finding of a primary tumor limited to the site of growth. The definition of T1c TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that is more than 1.0 cm, but not more than 2.0 cm in greatest dimension; for uterine corpus cancer it refers to a primary tumor that invades one-half or more of the myometrium; and for melanoma of the iris it refers to a primary tumor limited to the iris with secondary glaucoma. ncit:C48724 http://purl.bioontology.org/ontology/NCIT T2 Stage Finding EuroCAT Umbrella Protocol for NSCLC A general term that refers to a TNM finding of primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to primary tumor that is more than 2.0 cm, but not more than 5.0 cm in greatest dimension; for cutaneous melanoma it refers to primary tumor that is 1.01 to 2 mm in thickness, with or without ulceration; for colorectal cancer it refers to primary tumor with invasion into the muscularis propria; and for bladder cancer it refers to primary tumor with invasion into the muscle layer. ncit:C48725 http://purl.bioontology.org/ontology/NCIT T2a Stage Finding EuroCAT Umbrella Protocol for NSCLC A general term that refers to a TNM finding of a primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2a TNM finding depends on the specific type of cancer that it refers to; for example, for kidney cancer it refers to a primary tumor that measures more than 7 cm but less than or equal to 10 cm in greatest dimension, and is limited to the kidney; for bladder cancer it refers to a primary tumor that invades the superficial muscularis propria (inner half); for cervical cancer it refers to a primary tumor that invades beyond the uterus but not to the pelvic wall or to the lower third of vagina and there is no parametrial invasion. ncit:C48726 http://purl.bioontology.org/ontology/NCIT T2b Stage Finding EuroCAT Umbrella Protocol for NSCLC A general term that refers to a TNM finding of a primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2b TNM finding depends on the specific type of cancer that it refers to; for example, for kidney cancer it refers to a primary tumor that measures more than 10 cm in greatest dimension, and is limited to the kidney; for bladder cancer it refers to a primary tumor that invades the deep muscularis propria (outer half); for cervical cancer it refers to a primary tumor that invades beyond the uterus but not to the pelvic wall or to the lower third of vagina and there is parametrial invasion. ncit:C48727 http://purl.bioontology.org/ontology/NCIT T2c Stage Finding A general term that refers to a TNM finding of a primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2c TNM finding depends on the specific type of cancer that it refers to; for example, for prostate cancer it refers to a primary tumor that involves both lobes of the prostate gland; for ovarian cancer it refers to a primary tumor that involves one or both ovaries with extension or implants on the uterus and/or fallopian tubes, or other pelvic tissues, with malignant cells in either ascites or peritoneal washings; for fallopian tube cancer it refers to a primary tumor with pelvic extension and malignant cells in ascites or peritoneal washings. ncit:C48728 http://purl.bioontology.org/ontology/NCIT T3 Stage Finding EuroCAT Umbrella Protocol for NSCLC A clinical and/or pathologic primary tumor TNM finding usually indicating that the cancer is locally invasive, without infiltration of adjacent structures. ncit:C48732 http://purl.bioontology.org/ontology/NCIT T4 Stage Finding EuroCAT Umbrella Protocol for NSCLC A clinical and/or pathologic primary tumor TNM finding indicating direct invasion of adjacent structures by cancer. ncit:C48737 http://purl.bioontology.org/ontology/NCIT TX Stage Finding EuroCAT Umbrella Protocol for NSCLC A primary tumor TNM finding indicating that the status of the primary tumor cannot be assessed. ncit:C48738 http://purl.bioontology.org/ontology/NCIT Tis Stage Finding EuroCAT Umbrella Protocol for NSCLC A term that refers to a TNM finding of a primary tumor microscopically defined as carcinoma in situ. ncit:C48739 http://purl.bioontology.org/ontology/NCIT Pathologic TNM Finding EuroCAT Umbrella Protocol for NSCLC TNM staging performed as part of pathologic specimen. ncit:C48786 http://purl.bioontology.org/ontology/NCIT N2 Stage Finding EuroCAT Umbrella Protocol for NSCLC A general term that refers to a TNM finding of cancer metastases in several regional lymph nodes. The definition of N2 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 4-9 axillary lymph nodes; for cutaneous melanoma it refers to metastases in 2-3 regional lymph nodes; for colorectal cancer it refers to metastases in 4 or more regional lymph nodes; and for bladder cancer it refers to metastases in multiple regional lymph nodes in the true pelvis. ncit:C48879 http://purl.bioontology.org/ontology/NCIT Generic TNM Finding EuroCAT Umbrella Protocol for NSCLC A cancer finding in the TNM system that is not specifically identified as a clinical, pathologic, recurrent (retreatment), or autopsy classification using an accepted prefix in accordance with TNM classification guidelines. Though the 6th Edition of the AJCC Cancer Staging Manual indicates that unspecified TNM staging descriptors may be considered synonymous with the corresponding fully specified clinical category, such omission may lead to ambiguity in meaning, and in practice unqualified descriptors are frequently used with other intended meanings. The generic TNM concepts in the NCI Thesaurus are intended to explicitly reflect this lack of specification. ncit:C48881 http://purl.bioontology.org/ontology/NCIT Clinical TNM Finding EuroCAT Umbrella Protocol for NSCLC TNM staging performed with access to clinical information only. ncit:C48883 http://purl.bioontology.org/ontology/NCIT Generic Distant Metastasis TNM Finding EuroCAT Umbrella Protocol for NSCLC ncit:C48884 http://purl.bioontology.org/ontology/NCIT Generic Regional Lymph Nodes TNM Finding EuroCAT Umbrella Protocol for NSCLC ncit:C48885 http://purl.bioontology.org/ontology/NCIT Generic Primary Tumor TNM Finding EuroCAT Umbrella Protocol for NSCLC ncit:C48886 http://purl.bioontology.org/ontology/NCIT Pathologic Distant Metastasis TNM Finding EuroCAT Umbrella Protocol for NSCLC ncit:C48887 http://purl.bioontology.org/ontology/NCIT Pathologic Regional Lymph Nodes TNM Finding EuroCAT Umbrella Protocol for NSCLC A pathologic finding about one or more characteristics of a specific cancer, following the rules of the TNM classification system as they pertain to staging of regional lymph nodes. ncit:C48888 http://purl.bioontology.org/ontology/NCIT Pathologic Primary Tumor TNM Finding EuroCAT Umbrella Protocol for NSCLC A pathologic finding about one or more characteristics of a specific cancer, following the rules of the TNM classification system as they pertain to staging of the primary tumor. ncit:C48935 http://purl.bioontology.org/ontology/NCIT Regional Lymph Node Dissection Surgical removal of the lymph nodes located in a particular anatomic region. This procedure is commonly performed as a component of cancer staging. ncit:C48944 http://purl.bioontology.org/ontology/NCIT Lobe of the Right Lung EuroCAT Umbrella Protocol for NSCLC One of the three lobes that comprise the right lung. ncit:C48945 http://purl.bioontology.org/ontology/NCIT Lobe of the Left Lung EuroCAT Umbrella Protocol for NSCLC Either of the two (upper or lower) lobes that comprise the left lung. ncit:C491 http://purl.bioontology.org/ontology/NCIT Etoposide EuroCAT Umbrella Protocol for NSCLC A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04) ncit:C4917 http://purl.bioontology.org/ontology/NCIT Small Cell Lung Carcinoma A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis. ncit:C49236 http://purl.bioontology.org/ontology/NCIT Therapeutic Procedure An action or administration of therapeutic agents to produce an effect that is intended to alter or stop a pathologic process. ncit:C505 http://purl.bioontology.org/ontology/NCIT Fluorouracil 5-FU 5-Fluorouracil ncit:C50646 http://purl.bioontology.org/ontology/NCIT Medical Contraindication A symptom or medical condition that makes a particular treatment or procedure inadvisable because a person is likely to have a bad reaction. ncit:C50995 http://purl.bioontology.org/ontology/NCIT Disease Response Response The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. ncit:C51625 http://purl.bioontology.org/ontology/NCIT Wedge Resection of Lung EuroCAT Umbrella Protocol for NSCLC Surgical removal of a wedge-shaped section of lung. ncit:C51773 http://purl.bioontology.org/ontology/NCIT Married EuroCAT Umbrella Protocol for NSCLC Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together. ncit:C51774 http://purl.bioontology.org/ontology/NCIT Never Married Indicates a person who has never been married or whose marriages have been annulled. ncit:C51775 http://purl.bioontology.org/ontology/NCIT Widowed Indicates a person who is no longer married because of the death of his/her spouse and has not remarried. ncit:C51776 http://purl.bioontology.org/ontology/NCIT Divorced Indicates a person whose marriage has been legally dissolved and has not remarried. ncit:C51777 http://purl.bioontology.org/ontology/NCIT Separated Indicates a person living apart from his/her spouse by legal arrangement. ncit:C51949 http://purl.bioontology.org/ontology/NCIT Lymphocyte Count The determination of the number of lymphocytes in a blood sample. ncit:C53255 http://purl.bioontology.org/ontology/NCIT Adverse Event Attribution Category EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the determination of whether an adverse event is related to medical product or procedure or related to the cancer or related to comorbidities. ncit:C53256 http://purl.bioontology.org/ontology/NCIT Unrelated to Intervention EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as clearly not related to the medical intervention. ncit:C53257 http://purl.bioontology.org/ontology/NCIT Unlikely Related to Intervention EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as unlikely related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a temporal relationship to the medical intervention which makes a causal relationship improbable, and in which other interventions or underlying disease provide plausible explanations. ncit:C53258 http://purl.bioontology.org/ontology/NCIT Possibly Related to Intervention EuroCAT Umbrella Protocol for NSCLC A characteristic indicating that an adverse event may be related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a reasonable time sequence to administration of the drug, but which could also be explained by concurrent disease or other drugs or chemicals. Information on drug withdrawal may be lacking or unclear. ncit:C53259 http://purl.bioontology.org/ontology/NCIT Probably Related to Intervention EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as likely related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a reasonable time sequence to the medical intervention, unlikely to be attributed to concurrent disease or other medical interventions, and which follows a clinically reasonable response on withdrawal (dechallenge). Rechallenge information is not required to fulfill this definition. ncit:C53260 http://purl.bioontology.org/ontology/NCIT Definitely Related to Intervention EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as certainly related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, occurring in a plausible time relationship to medical intervention, and which cannot be explained by concurrent disease or other interventions. The response to withdrawal of the medical product (dechallenge) should be clinically plausible. The event must be definitive pharmacologically or phenomenologically, using a satisfactory rechallenge procedure if necessary. ncit:C53262 http://purl.bioontology.org/ontology/NCIT Domestic Partnership Indicates a person who is a member of an unmarried couple, including same sex couples, living together in longstanding relationships, that are registered or unregistered. ncit:C53288 http://purl.bioontology.org/ontology/NCIT Temporary Not permanent; not lasting; lacking continuity or regularity. ncit:C53781 http://purl.bioontology.org/ontology/NCIT Adverse Event by CTCAE Category ncit:C53795 http://purl.bioontology.org/ontology/NCIT Adverse Event Associated with Pulmonary and Upper Respiratory Systems ncit:C53802 http://purl.bioontology.org/ontology/NCIT Adverse Event Associated with the Gastrointestinal System ncit:C53803 http://purl.bioontology.org/ontology/NCIT Adverse Event Associated with the Heart in General ncit:C54100 http://purl.bioontology.org/ontology/NCIT Universally Unique Identifier A 128 bit identifier. Depending on the mechanism used to generate it, it is either guaranteed to be different from all other UUIDs/GUIDs generated until 3400 AD or extremely likely to be different. Its relatively small size lends itself well to sorting, ordering, and hashing of all sorts, storing in databases, simple allocation, and ease of programming in general. ncit:C54996 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 1 Hypertension Asymptomatic, transient (<24 hrs) increase by >20 mmHg (diastolic) or to >150/100 if previously WNL; intervention not indicated Pediatric: Asymptomatic, transient (<24 hrs) BP increase >ULN; intervention not indicated ncit:C55008 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 2 Hypertension Recurrent or persistent (>=24 hrs) or symptomatic increase by >20 mmHg (diastolic) or to >150/100 if previously WNL; monotherapy may be indicated Pediatric: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy may be indicated ncit:C55020 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 3 Hypertension Requiring more than one drug or more intensive therapy than previously Pediatric: Same as adult ncit:C55034 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 4 Hypertension Life-threatening consequences (e.g., hypertensive crisis) Pediatric: Same as adult ncit:C55048 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 5 Hypertension Death ncit:C55060 http://purl.bioontology.org/ontology/NCIT Hypertension Adverse Event ncit:C55072 http://purl.bioontology.org/ontology/NCIT Recurrent Disease, Primary Site Recurrence of symptoms of a disease at the original site. ncit:C55073 http://purl.bioontology.org/ontology/NCIT Recurrent Disease, Distant Site Recurrence of symptoms of a disease, at a site different and away from the original site. ncit:C57176 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 1 Dysphagia Symptomatic, able to eat regular diet ncit:C57299 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 2 Dysphagia Symptomatic and altered eating/swallowing (e.g., altered dietary habits, oral supplements); IV fluids indicated <24 hrs ncit:C57425 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 3 Dysphagia Symptomatic and severely altered eating/swallowing (e.g., inadequate oral caloric or fluid intake); IV fluids, tube feedings, or TPN indicated >=24 hrs ncit:C57560 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 4 Dysphagia Life-threatening consequences (e.g., obstruction, perforation) ncit:C57691 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 5 Dysphagia Death ncit:C57795 http://purl.bioontology.org/ontology/NCIT Dysphagia Adverse Event ncit:C58037 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 1 Dyspnea Dyspnea on exertion, but can walk 1 flight of stairs without stopping ncit:C58066 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 2 Dyspnea Dyspnea on exertion but unable to walk 1 flight of stairs or 1 city block (0.1km) without stopping ncit:C58099 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 3 Dyspnea Dyspnea with ADL. ncit:C58131 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 4 Dyspnea Dyspnea at rest; intubation/ventilator indicated. ncit:C58162 http://purl.bioontology.org/ontology/NCIT CTCAE Grade 5 Dyspnea Death. ncit:C58185 http://purl.bioontology.org/ontology/NCIT Dyspnea Adverse Event ncit:C607 http://purl.bioontology.org/ontology/NCIT Leucovorin Calcium Calcium Folinate ncit:C61614 http://purl.bioontology.org/ontology/NCIT Pemetrexed EuroCAT Umbrella Protocol for NSCLC A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. ncit:C62040 http://purl.bioontology.org/ontology/NCIT Irinotecan EuroCAT Umbrella Protocol for NSCLC A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent. ncit:C62165 http://purl.bioontology.org/ontology/NCIT Prone Position Prone An anterior recumbent body position whereby the person lies on its stomach and faces downward. ncit:C62167 http://purl.bioontology.org/ontology/NCIT Supine Position Supine A posterior recumbent body position whereby the person lies on its back and faces upward. ncit:C62220 http://purl.bioontology.org/ontology/NCIT Cure EuroCAT Umbrella Protocol for NSCLC Serving or tending to restore health; a remedy. ncit:C62398 http://purl.bioontology.org/ontology/NCIT Transanal Excision Surgery for rectal cancer that spares the anus and leaves the sphincter intact. Surgery is performed through the anus and removes only the rectal tumor and small amounts of surrounding tissue. ncit:C62727 http://purl.bioontology.org/ontology/NCIT Image Guided Radiation Therapy EuroCAT Umbrella Protocol for NSCLC IGRT A procedure that uses a computer to create a picture of a tumor to help guide the radiation beam during radiation therapy. The pictures are made using CT, ultrasound, X-ray, or other imaging techniques. Image-guided radiation therapy makes radiation therapy more accurate and causes less damage to healthy tissue. ncit:C62731 http://purl.bioontology.org/ontology/NCIT Tomotherapy A type of external beam radiation therapy in which the radiation is delivered slice-by-slice, providing sequential delivery of radiation to different parts of the tumor. This method differs from other forms of radiation therapy in which the entire tumor volume is irradiated at one time. ncit:C63388 http://purl.bioontology.org/ontology/NCIT FU-LV Regimen Fluorouracil-Leucovorin Regimen Mayo Clinic Regimen Roswell Park Regimen de Gramont Regimen A regimen consisting of fluorouracil and leucovorin, used in both the adjuvant and metastatic disease setting, for the treatment of colorectal cancer. This regimen is also combined with radiation for the treatment of gastric and esophageal cancer. The Mayo Clinic regimen, Roswell Park regimen, and de Gramont regimen are different in the doses and times at which the two drugs are given. ncit:C63536 http://purl.bioontology.org/ontology/NCIT Study A detailed examination, analysis, or critical inspection of a subject designed to discover facts about it. ncit:C63586 Chemotherapy Regimen Used to Treat Colorectal Carcinoma ncit:C63593 http://purl.bioontology.org/ontology/NCIT FOLFIRI Regimen FOLFIRI Folinic Acid-Fluorouracil-Irinotecan Regimen A chemotherapy regimen consisting of leucovorin calcium (calcium folinate), 5-fluorouracil, and irinotecan used in the treatment of advanced-stage and metastatic colorectal cancer. ncit:C63597 http://purl.bioontology.org/ontology/NCIT XELOX regimen XELOX Xeloda-Oxaliplatin Regimen Xeloda/Oxalipaltin A regimen consisting of capecitabine and oxaliplatin used for the treatment of advanced stage colorectal cancer. This regimen differs from a similar regimen, CAPOX, with regards to the dosing schedule for oxaliplatin. ncit:C64247 http://purl.bioontology.org/ontology/NCIT Inoperable EuroCAT Umbrella Protocol for NSCLC Not suitable for surgery. ncit:C64848 http://purl.bioontology.org/ontology/NCIT Hemoglobin Measurement A quantitative measurement of the amount of hemoglobin present in a sample. ncit:C64982 http://purl.bioontology.org/ontology/NCIT Therapeutic Surgical Procedure ncit:C65108 http://purl.bioontology.org/ontology/NCIT Never Smoker EuroCAT Umbrella Protocol for NSCLC A person who was not smoking at the time of the interview and has smoked less than 100 cigarettes in their life. ncit:C65151 http://purl.bioontology.org/ontology/NCIT Non-Small Cell Carcinoma EuroCAT Umbrella Protocol for NSCLC A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma. ncit:C65530 http://purl.bioontology.org/ontology/NCIT Erlotinib EuroCAT Umbrella Protocol for NSCLC A quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation. ncit:C66876 http://purl.bioontology.org/ontology/NCIT Gemcitabine EuroCAT Umbrella Protocol for NSCLC A broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity. Upon administration, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA. This locks DNA polymerase thereby resulting in "masked termination" during DNA replication. On the other hand, dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis. The reduction in the intracellular concentration of dCTP potentiates the incorporation of dFdCTP into DNA. ncit:C66897 http://purl.bioontology.org/ontology/NCIT Proton Beam Radiation Therapy A type of external beam radiation therapy using a beam of protons. It has the advantage of precisely localizing the radiation dose on the targeted tissue and avoiding damage to the healthy surrounding tissues. ncit:C67147 http://purl.bioontology.org/ontology/NCIT Current Smoker EuroCAT Umbrella Protocol for NSCLC An adult who has smoked 100 cigarettes in his or her lifetime and who currently smokes cigarettes. Includes daily smokers and non-daily smokers (also known as occasional smokers). ncit:C67148 http://purl.bioontology.org/ontology/NCIT Former Smoker EuroCAT Umbrella Protocol for NSCLC A person who was not smoking at the time of the interview but has smoked at least 100 cigarettes in their life. ncit:C68618 http://purl.bioontology.org/ontology/NCIT Conditionally Related to Intervention EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as unclassified in term of its relation to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to clinical event, including laboratory test abnormality, reported as an adverse reaction, about which more data is essential for a proper assessment or the additional data are under examination. ncit:C68619 http://purl.bioontology.org/ontology/NCIT Relation to Intervention Unclassifiable EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as unclassifiable in term of its relation to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to an adverse reaction which cannot be judged because information about it is insufficient or contradictory, and cannot be supplemented or verified. ncit:C68786 http://purl.bioontology.org/ontology/NCIT Radical Directed to the root or source of a morbid process; to remove the root of a disease or all diseased tissue, as radical surgery. ncit:C69219 http://purl.bioontology.org/ontology/NCIT Series Instance UID A unique identifier for series of images. ncit:C69310 http://purl.bioontology.org/ontology/NCIT Standardized Uptake Value An effectively dimensionless measure of regional tracer uptake calculated as the activity concentration within a 2D region of interest (ROI) or 3D volume of interest (VOI) measured on a PET image (nCi1mL) / [injected dose (nCi) / body weight (g)]. ncit:C70663 http://purl.bioontology.org/ontology/NCIT Unique Identifier A set of characters used as a code that is unique in the context or the system for which it is created. It serves as a means of identification and reference (often instead of a name) for an entity, person, thing, function, procedure, activity, variable, or body of data. ncit:C70699 http://purl.bioontology.org/ontology/NCIT Biospecimen Any material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes, including a sample obtained from a living organism or taken from the biological object after halting of all its life functions. Biospecimen can contain one or more components including but not limited to cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory products. ncit:C70838 http://purl.bioontology.org/ontology/NCIT Image Feature In image processing, a piece of information which is relevant for solving the computational task related to a certain application, either specific structures in the image itself (e.g., simple structures such as points or edges to more complex structures such as objects) or the result of a general neighborhood operation (feature extractor or feature detector) applied to the image. ncit:C71160 http://purl.bioontology.org/ontology/NCIT Instance Unique Identifier Data type unique identifier within a particular context. ncit:C7377 http://purl.bioontology.org/ontology/NCIT Malignant Lung Neoplasm A primary or metastatic malignant neoplasm involving the lung. ncit:C73993 http://purl.bioontology.org/ontology/NCIT Pack Year EuroCAT Umbrella Protocol for NSCLC A quantification of lifetime tobacco exposure defined as (number of cigarettes smoked per day x number of years smoked)/20. One pack-year is smoking 20 cigarettes a day for one year. ncit:C7418 http://purl.bioontology.org/ontology/NCIT Malignant Rectal Neoplasm A primary or metastatic malignant neoplasm that affects the rectum. Representative examples include carcinoma, lymphoma, and sarcoma. ncit:C7420 http://purl.bioontology.org/ontology/NCIT Malignant Rectosigmoid Neoplasm A primary or metastatic malignant neoplasm that affects the rectosigmoid area. Representative examples include carcinoma, lymphoma, and sarcoma. ncit:C7919 http://purl.bioontology.org/ontology/NCIT No Measurable or Evaluable Disease ncit:C81239 http://purl.bioontology.org/ontology/NCIT Cause of Death The circumstance or condition that results in the death of a living being. ncit:C81262 http://purl.bioontology.org/ontology/NCIT Medical Record Number An identifying number within an institution that is used to reference a subject's medical information. ncit:C81328 http://purl.bioontology.org/ontology/NCIT Body Weight EuroCAT Umbrella Protocol for NSCLC The weight of a subject. ncit:C81945 http://purl.bioontology.org/ontology/NCIT ALK Gene Mutation EuroCAT Umbrella Protocol for NSCLC ncit:C82572 http://purl.bioontology.org/ontology/NCIT Elapsed Time The interval between two reference points in time. ncit:C83083 http://purl.bioontology.org/ontology/NCIT Subject Identifier EuroCAT Umbrella Protocol for NSCLC Studynumber A sequence of characters used to identify, name, or characterize the study subject. ncit:C84257 http://purl.bioontology.org/ontology/NCIT Adverse Event by CTCAE v3 Severity Grade ncit:C84259 http://purl.bioontology.org/ontology/NCIT Adverse Event by CTCAE v4 Severity Grade ncit:C85402 http://purl.bioontology.org/ontology/NCIT Imaging Region of Interest A specific area of interest defined by a sequence of image overlays or a sequence of contours described as a single point (for a point ROI) or more than one point (representing and open or closed polygon). ncit:C857 http://purl.bioontology.org/ontology/NCIT Teniposide EuroCAT Umbrella Protocol for NSCLC A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04) ncit:C91826 http://purl.bioontology.org/ontology/NCIT Abdominoperineal Resection A therapeutic surgical procedure in which the anus, rectum, part of the sigmoid colon, and the regional lymph nodes are removed through abdominal and perineal incisions. ncit:C930 http://purl.bioontology.org/ontology/NCIT Vinblastine EuroCAT Umbrella Protocol for NSCLC A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04) ncit:C9311 http://purl.bioontology.org/ontology/NCIT Malignant Cervical Neoplasm Primary or metastatic malignant neoplasm involving the cervix. --2003 ncit:C932 http://purl.bioontology.org/ontology/NCIT Vinca Alkaloid Compound A type of drug that blocks cell growth by stopping mitosis (cell division). Vinca alkaloids interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer. A vinca alkaloid is a type of mitotic inhibitor and a type of antimicrotubule agent. ncit:C933 http://purl.bioontology.org/ontology/NCIT Vincristine EuroCAT Umbrella Protocol for NSCLC A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04) ncit:C934 http://purl.bioontology.org/ontology/NCIT Vindesine EuroCAT Umbrella Protocol for NSCLC A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04) ncit:C94254 http://purl.bioontology.org/ontology/NCIT Operable EuroCAT Umbrella Protocol for NSCLC Describes a condition that can be treated by surgery. ncit:C94448 http://purl.bioontology.org/ontology/NCIT Sleeve Lobectomy EuroCAT Umbrella Protocol for NSCLC Surgery to remove a lung tumor in a lobe of the lung and a part of the main bronchus (airway). The ends of the bronchus are rejoined and any remaining lobes are reattached to the bronchus. This surgery is done to save part of the lung. ncit:C94461 http://purl.bioontology.org/ontology/NCIT Metastasectomy The surgical removal of metastases. ncit:C94488 http://purl.bioontology.org/ontology/NCIT Stature EuroCAT Umbrella Protocol for NSCLC The height of a person while standing. ncit:C94515 http://purl.bioontology.org/ontology/NCIT Tumor Volume The size of a cancer measured by the amount of space taken up by the tumor. For example, the tumor volume of prostate cancer is the percentage of the prostate taken up by the tumor. ncit:C94626 http://purl.bioontology.org/ontology/NCIT Chemoradiotherapy EuroCAT Umbrella Protocol for NSCLC Treatment that combines chemotherapy with radiation therapy ncit:C95181 Absorbed Radiation Dose The amount of energy from any type of ionizing radiation (e.g., alpha, beta, gamma, neutrons, etc.) deposited in any medium (e.g. water, tissue, air). This designates energy deposition by the radiation without regard to the type of matter or any biological considerations. ncit:C95484 http://purl.bioontology.org/ontology/NCIT CyberKnife A proprietary, robotic radiosurgery system designed to deliver precise beams of high dose radiation to tumors with extreme accuracy. ncit:C95560 http://purl.bioontology.org/ontology/NCIT Prophylactic In medicine, something that prevents or protects. ncit:C95805 http://purl.bioontology.org/ontology/NCIT T1mi Stage Finding A term that refers to a TNM finding of a primary tumor limited to the site of growth and indicates microinvasion only. ncit:C96866 http://purl.bioontology.org/ontology/NCIT ERBB2 Gene Mutation EuroCAT Umbrella Protocol for NSCLC HER2 Gene Mutation A molecular genetic abnormality indicating the presence of a mutation in the ERBB2 gene on chromosome 17q12. ncit:C98304 http://purl.bioontology.org/ontology/NCIT AKT1 Gene Mutation EuroCAT Umbrella Protocol for NSCLC A change in the nucleotide sequence of the AKT1 gene. ncit:C98357 http://purl.bioontology.org/ontology/NCIT EGFR Gene Mutation EuroCAT Umbrella Protocol for NSCLC A change in the nucleotide sequence of the EGFR gene. ctcae:Adverse_Event_by_System_Organ_Class http://purl.bioontology.org/ontology/CTCAE Adverse Event by System Organ Class ctcae:Cough http://purl.bioontology.org/ontology/CTCAE Cough EuroCAT Umbrella Protocol for NSCLC A disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound. ctcae:Dysphagia http://purl.bioontology.org/ontology/CTCAE Dysphagia EuroCAT Umbrella Protocol for NSCLC A disorder characterized by difficulty in swallowing. ctcae:Dyspnea http://purl.bioontology.org/ontology/CTCAE Dyspnea EuroCAT Umbrella Protocol for NSCLC A disorder characterized by an uncomfortable sensation of difficulty breathing. ctcae:Esophageal_stenosis http://purl.bioontology.org/ontology/CTCAE Esophageal stenosis EuroCAT Umbrella Protocol for NSCLC A disorder characterized by a narrowing of the lumen of the esophagus. ctcae:Gastrointestinal_disorders http://purl.bioontology.org/ontology/CTCAE Gastrointestinal disorders ctcae:Grade_1_Cough http://purl.bioontology.org/ontology/CTCAE Grade 1 Cough EuroCAT Umbrella Protocol for NSCLC Mild symptoms; nonprescription intervention indicated ctcae:Grade_1_Dysphagia http://purl.bioontology.org/ontology/CTCAE Grade 1 Dysphagia EuroCAT Umbrella Protocol for NSCLC Symptomatic, able to eat regular diet ctcae:Grade_1_Dyspnea http://purl.bioontology.org/ontology/CTCAE Grade 1 Dyspnea EuroCAT Umbrella Protocol for NSCLC Shortness of breath with moderate exertion ctcae:Grade_1_Esophageal_stenosis http://purl.bioontology.org/ontology/CTCAE Grade 1 Esophageal stenosis EuroCAT Umbrella Protocol for NSCLC Asymptomatic; clinical or diagnostic observations only; intervention not indicated ctcae:Grade_2_Cough http://purl.bioontology.org/ontology/CTCAE Grade 2 Cough EuroCAT Umbrella Protocol for NSCLC Moderate symptoms, medical intervention indicated; limiting instrumental ADL ctcae:Grade_2_Dysphagia http://purl.bioontology.org/ontology/CTCAE Grade 2 Dysphagia EuroCAT Umbrella Protocol for NSCLC Symptomatic and altered eating/swallowing ctcae:Grade_2_Dyspnea http://purl.bioontology.org/ontology/CTCAE Grade 2 Dyspnea EuroCAT Umbrella Protocol for NSCLC Shortness of breath with minimal exertion; limiting instrumental ADL ctcae:Grade_2_Esophageal_stenosis http://purl.bioontology.org/ontology/CTCAE Grade 2 Esophageal stenosis EuroCAT Umbrella Protocol for NSCLC Symptomatic; altered GI function ctcae:Grade_3_Cough http://purl.bioontology.org/ontology/CTCAE Grade 3 Cough EuroCAT Umbrella Protocol for NSCLC Severe symptoms; limiting self care ADL ctcae:Grade_3_Dysphagia http://purl.bioontology.org/ontology/CTCAE Grade 3 Dysphagia EuroCAT Umbrella Protocol for NSCLC Severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated ctcae:Grade_3_Dyspnea http://purl.bioontology.org/ontology/CTCAE Grade 3 Dyspnea EuroCAT Umbrella Protocol for NSCLC Shortness of breath at rest; limiting self care ADL ctcae:Grade_3_Esophageal_stenosis http://purl.bioontology.org/ontology/CTCAE Grade 3 Esophageal stenosis EuroCAT Umbrella Protocol for NSCLC Severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated ctcae:Grade_4_Dysphagia http://purl.bioontology.org/ontology/CTCAE Grade 4 Dysphagia EuroCAT Umbrella Protocol for NSCLC Life-threatening consequences; urgent intervention indicated ctcae:Grade_4_Dyspnea http://purl.bioontology.org/ontology/CTCAE Grade 4 Dyspnea EuroCAT Umbrella Protocol for NSCLC Life-threatening consequences; urgent intervention indicated ctcae:Grade_4_Esophageal_stenosis http://purl.bioontology.org/ontology/CTCAE Grade 4 Esophageal stenosis EuroCAT Umbrella Protocol for NSCLC Life-threatening consequences; urgent operative intervention indicated ctcae:Grade_5_Dysphagia http://purl.bioontology.org/ontology/CTCAE Grade 5 Dysphagia EuroCAT Umbrella Protocol for NSCLC Death ctcae:Grade_5_Dyspnea http://purl.bioontology.org/ontology/CTCAE Grade 5 Dyspnea EuroCAT Umbrella Protocol for NSCLC Death ctcae:Grade_5_Esophageal_stenosis http://purl.bioontology.org/ontology/CTCAE Grade 5 Esophageal stenosis EuroCAT Umbrella Protocol for NSCLC Death ctcae:Respiratory_thoracic_and_mediastinal_disorders http://purl.bioontology.org/ontology/CTCAE Respiratory, thoracic and mediastinal disorders icd10:C19 http://purl.bioontology.org/ontology/ICD10 Malignant neoplasm of rectosigmoid junction icd10:C20 http://purl.bioontology.org/ontology/ICD10 Malignant neoplasm of rectum icd10:C34 http://purl.bioontology.org/ontology/ICD10 Malignant neoplasm of bronchus and lung http://purl.bioontology.org/ontology/ICD9CM Segmental resection of lung EuroCAT Umbrella Protocol for NSCLC Partial lobectomy A segment resection removes a larger portion of the lung lobe than a wedge resection, but does not remove the whole lobe. http://purl.bioontology.org/ontology/ICD9CM Lobectomy of Lung EuroCAT Umbrella Protocol for NSCLC Pulmonary lobectomy A common surgical procedure that removes one lobe of the lung that contains cancerous cells. rcd:X20XN http://purl.bioontology.org/ontology/RCD Colostomy operation The surgical creation or closure of an opening between the colon and the surface of the body. rcd:X20Y4 http://purl.bioontology.org/ontology/RCD Anterior resection of rectum rcd:X78tq http://purl.bioontology.org/ontology/RCD Permanent rcd:X7A6g http://purl.bioontology.org/ontology/RCD Residual tumour status stages EuroCAT Umbrella Protocol for NSCLC The R classification, an auxiliary classification within the TNM system, denotes the absence or presence of residual tumor after treatment and describes residual tumor as macroscopic or microscopic in amount. The R classification considers residual tumor at the primary tumor siteThe R classification, an auxiliary classification within the TNM system, denotes the absence or presence of residual tumor after treatment and describes residual tumor as macroscopic or microscopic in amount. The R classification considers residual tumor at the primary tumor site, in the regional lymph nodes, and/or at distant sites. As such, it reflects the efficacy of primary treatment, influences the design and institution of additional therapy, and is a strong indicator of prognosis., in the regional lymph nodes, and/or at distant sites. As such, it reflects the efficacy of primary treatment, influences the design and institution of additional therapy, and is a strong indicator of prognosis. rcd:X7A6h http://purl.bioontology.org/ontology/RCD Residual tumour stage RX EuroCAT Umbrella Protocol for NSCLC The presence of residual tumor cannot be assessed. rcd:X7A6i http://purl.bioontology.org/ontology/RCD Residual tumour stage R0 EuroCAT Umbrella Protocol for NSCLC No residual tumor. rcd:XC0fs http://purl.bioontology.org/ontology/RCD Colostomy - stoma Colostomy A stoma to the colon. rcd:XE0DI http://purl.bioontology.org/ontology/RCD Construction of temporary colostomy The surgical creation of a temporary colostomy. rcd:XE0DJ http://purl.bioontology.org/ontology/RCD Construction of permanent colostomy The surgical creation of a permanent colostomy. rcd:XE0DK http://purl.bioontology.org/ontology/RCD Closure of colostomy The surgical closure of a colostomy. rcd:Xa0fY http://purl.bioontology.org/ontology/RCD Residual tumour stage R1 EuroCAT Umbrella Protocol for NSCLC Microscopic residual tumor. rcd:Xa0fZ http://purl.bioontology.org/ontology/RCD Residual tumour stage R2 EuroCAT Umbrella Protocol for NSCLC Macroscopic residual tumor. rcd:Xa1oS http://purl.bioontology.org/ontology/RCD Excision of lesion of rectum Local excision http://purl.bioontology.org/ontology/RCD Saliva sample EuroCAT Umbrella Protocol for NSCLC http://purl.bioontology.org/ontology/RCD Radiotherapy - preoperative control The use of radiotherapy prior to the surgical removal of a tumor. http://purl.bioontology.org/ontology/RCD Radiotherapy - postoperative control A postoperative course of radiotherapy. http://purl.bioontology.org/ontology/RCD Hartmann's procedure Rectosigmoidectomy, closure of rectal stump and exteriorisation of bowel. sty:T001 http://purl.bioontology.org/ontology/STY Organism Generally, a living individual, including all plants and animals. sty:T002 http://purl.bioontology.org/ontology/STY Plant An organism having cellulose cell walls, growing by synthesis of inorganic substances, generally distinguished by the presence of chlorophyll, and lacking the power of locomotion. Plant parts are included here as well. sty:T004 http://purl.bioontology.org/ontology/STY Fungus A eukaryotic organism characterized by the absence of chlorophyll and the presence of a rigid cell wall. Included here are both slime molds and true fungi such as yeasts, molds, mildews, and mushrooms. sty:T005 http://purl.bioontology.org/ontology/STY Virus An organism consisting of a core of a single nucleic acid enclosed in a protective coat of protein. A virus may replicate only inside a host living cell. A virus exhibits some but not all of the usual characteristics of living things. sty:T007 http://purl.bioontology.org/ontology/STY Bacterium A small, typically one-celled, prokaryotic micro-organism. sty:T008 http://purl.bioontology.org/ontology/STY Animal An organism with eukaryotic cells, and lacking stiff cell walls, plastids and photosynthetic pigments. sty:T010 http://purl.bioontology.org/ontology/STY Vertebrate An animal which has a spinal column. sty:T011 http://purl.bioontology.org/ontology/STY Amphibian A cold-blooded, smooth-skinned vertebrate which characteristically hatches as an aquatic larva, breathing by gills. When mature, the amphibian breathes with lungs. sty:T012 http://purl.bioontology.org/ontology/STY Bird A vertebrate having a constant body temperature and characterized by the presence of feathers. sty:T013 http://purl.bioontology.org/ontology/STY Fish A cold-blooded aquatic vertebrate characterized by fins and breathing by gills. Included here are fishes having either a bony skeleton, such as a perch, or a cartilaginous skeleton, such as a shark, or those lacking a jaw, such as a lamprey or hagfish. sty:T014 http://purl.bioontology.org/ontology/STY Reptile A cold-blooded vertebrate having an external covering of scales or horny plates. Reptiles breathe by means of lungs and are generally egg-laying. sty:T015 http://purl.bioontology.org/ontology/STY Mammal A vertebrate having a constant body temperature and characterized by the presence of hair, mammary glands and sweat glands. sty:T016 http://purl.bioontology.org/ontology/STY Human Modern man, the only remaining species of the Homo genus. sty:T017 http://purl.bioontology.org/ontology/STY Anatomical Structure A normal or pathological part of the anatomy or structural organization of an organism. sty:T018 http://purl.bioontology.org/ontology/STY Embryonic Structure An anatomical structure that exists only before the organism is fully formed; in mammals, for example, a structure that exists only prior to the birth of the organism. This structure may be normal or abnormal. sty:T019 http://purl.bioontology.org/ontology/STY Congenital Abnormality An abnormal structure, or one that is abnormal in size or location, present at birth or evolving over time as a result of a defect in embryogenesis. sty:T020 http://purl.bioontology.org/ontology/STY Acquired Abnormality An abnormal structure, or one that is abnormal in size or location, found in or deriving from a previously normal structure. Acquired abnormalities are distinguished from diseases even though they may result in pathological functioning (e.g., hernias incarcerate). sty:T021 http://purl.bioontology.org/ontology/STY Fully Formed Anatomical Structure An anatomical structure in a fully formed organism; in mammals, for example, a structure in the body after the birth of the organism. sty:T022 http://purl.bioontology.org/ontology/STY Body System A complex of anatomical structures that performs a common function. sty:T023 http://purl.bioontology.org/ontology/STY Body Part, Organ, or Organ Component A collection of cells and tissues which are localized to a specific area or combine and carry out one or more specialized functions of an organism. This ranges from gross structures to small components of complex organs. These structures are relatively localized in comparison to tissues. sty:T024 http://purl.bioontology.org/ontology/STY Tissue An aggregation of similarly specialized cells and the associated intercellular substance. Tissues are relatively non-localized in comparison to body parts, organs or organ components. sty:T025 http://purl.bioontology.org/ontology/STY Cell The fundamental structural and functional unit of living organisms. sty:T026 http://purl.bioontology.org/ontology/STY Cell Component A part of a cell or the intercellular matrix, generally visible by light microscopy. sty:T028 http://purl.bioontology.org/ontology/STY Gene or Genome A specific sequence, or in the case of the genome the complete sequence, of nucleotides along a molecule of DNA or RNA (in the case of some viruses) which represent the functional units of heredity. sty:T029 http://purl.bioontology.org/ontology/STY Body Location or Region An area, subdivision, or region of the body demarcated for the purpose of topographical description. sty:T030 http://purl.bioontology.org/ontology/STY Body Space or Junction An area enclosed or surrounded by body parts or organs or the place where two anatomical structures meet or connect. sty:T031 http://purl.bioontology.org/ontology/STY Body Substance Extracellular material, or mixtures of cells and extracellular material, produced, excreted, or accreted by the body. Included here are substances such as saliva, dental enamel, sweat, and gastric acid. sty:T032 http://purl.bioontology.org/ontology/STY Organism Attribute A property of the organism or its major parts. sty:T033 http://purl.bioontology.org/ontology/STY Finding That which is discovered by direct observation or measurement of an organism attribute or condition, including the clinical history of the patient. The history of the presence of a disease is a 'Finding' and is distinguished from the disease itself. sty:T034 http://purl.bioontology.org/ontology/STY Laboratory or Test Result The outcome of a specific test to measure an attribute or to determine the presence, absence, or degree of a condition. sty:T037 http://purl.bioontology.org/ontology/STY Injury or Poisoning A traumatic wound, injury, or poisoning caused by an external agent or force. sty:T038 http://purl.bioontology.org/ontology/STY Biologic Function A state, activity or process of the body or one of its systems or parts. sty:T039 http://purl.bioontology.org/ontology/STY Physiologic Function A normal process, activity, or state of the body. sty:T040 http://purl.bioontology.org/ontology/STY Organism Function A physiologic function of the organism as a whole, of multiple organ systems, or of multiple organs or tissues. sty:T041 http://purl.bioontology.org/ontology/STY Mental Process A physiologic function involving the mind or cognitive processing. sty:T042 http://purl.bioontology.org/ontology/STY Organ or Tissue Function A physiologic function of a particular organ, organ system, or tissue. sty:T043 http://purl.bioontology.org/ontology/STY Cell Function A physiologic function inherent to cells or cell components. sty:T044 http://purl.bioontology.org/ontology/STY Molecular Function A physiologic function occurring at the molecular level. sty:T045 http://purl.bioontology.org/ontology/STY Genetic Function Functions of or related to the maintenance, translation or expression of the genetic material. sty:T046 http://purl.bioontology.org/ontology/STY Pathologic Function A disordered process, activity, or state of the organism as a whole, of a body system or systems, or of multiple organs or tissues. Included here are normal responses to a negative stimulus as well as patholologic conditions or states that are less specific than a disease. Pathologic functions frequently have systemic effects. sty:T047 http://purl.bioontology.org/ontology/STY Disease or Syndrome A condition which alters or interferes with a normal process, state, or activity of an organism. It is usually characterized by the abnormal functioning of one or more of the host's systems, parts, or organs. Included here is a complex of symptoms descriptive of a disorder. sty:T048 http://purl.bioontology.org/ontology/STY Mental or Behavioral Dysfunction A clinically significant dysfunction whose major manifestation is behavioral or psychological. These dysfunctions may have identified or presumed biological etiologies or manifestations. sty:T049 http://purl.bioontology.org/ontology/STY Cell or Molecular Dysfunction A pathologic function inherent to cells, parts of cells, or molecules. sty:T050 http://purl.bioontology.org/ontology/STY Experimental Model of Disease A representation in a non-human organism of a human disease for the purpose of research into its mechanism or treatment. sty:T051 http://purl.bioontology.org/ontology/STY Event A broad type for grouping activities, processes and states. sty:T052 http://purl.bioontology.org/ontology/STY Activity An operation or series of operations that an organism or machine carries out or participates in. sty:T053 http://purl.bioontology.org/ontology/STY Behavior Any of the psycho-social activities of humans or animals that can be observed directly by others or can be made systematically observable by the use of special strategies. sty:T054 http://purl.bioontology.org/ontology/STY Social Behavior Behavior that is a direct result or function of the interaction of humans or animals with their fellows. This includes behavior that may be considered anti-social. sty:T055 http://purl.bioontology.org/ontology/STY Individual Behavior Behavior exhibited by a human or an animal that is not a direct result of interaction with other members of the species, but which may have an effect on others. sty:T056 http://purl.bioontology.org/ontology/STY Daily or Recreational Activity An activity carried out for recreation or exercise, or as part of daily life. sty:T057 http://purl.bioontology.org/ontology/STY Occupational Activity An activity carried out as part of an occupation or job. sty:T058 http://purl.bioontology.org/ontology/STY Health Care Activity An activity of or relating to the practice of medicine or involving the care of patients. sty:T059 http://purl.bioontology.org/ontology/STY Laboratory Procedure A procedure, method, or technique used to determine the composition, quantity, or concentration of a specimen, and which is carried out in a clinical laboratory. Included here are procedures which measure the times and rates of reactions. sty:T060 http://purl.bioontology.org/ontology/STY Diagnostic Procedure A procedure, method, or technique used to determine the nature or identity of a disease or disorder. This excludes procedures which are primarily carried out on specimens in a laboratory. sty:T061 http://purl.bioontology.org/ontology/STY Therapeutic or Preventive Procedure A procedure, method, or technique designed to prevent a disease or a disorder, or to improve physical function, or used in the process of treating a disease or injury. sty:T062 http://purl.bioontology.org/ontology/STY Research Activity An activity carried out as part of research or experimentation. sty:T063 http://purl.bioontology.org/ontology/STY Molecular Biology Research Technique Any of the techniques used in the study of or the directed modification of the gene complement of a living organism. sty:T064 http://purl.bioontology.org/ontology/STY Governmental or Regulatory Activity An activity carried out by officially constituted governments, or an activity related to the creation or enforcement of the rules or regulations governing some field of endeavor. sty:T065 http://purl.bioontology.org/ontology/STY Educational Activity An activity related to the organization and provision of education. sty:T066 http://purl.bioontology.org/ontology/STY Machine Activity An activity carried out primarily or exclusively by machines. sty:T067 http://purl.bioontology.org/ontology/STY Phenomenon or Process A process or state which occurs naturally or as a result of an activity. sty:T068 http://purl.bioontology.org/ontology/STY Human-caused Phenomenon or Process A phenomenon or process that is a result of the activities of human beings. sty:T069 http://purl.bioontology.org/ontology/STY Environmental Effect of Humans A change in the natural environment that is a result of the activities of human beings. sty:T070 http://purl.bioontology.org/ontology/STY Natural Phenomenon or Process A phenomenon or process that occurs irrespective of the activities of human beings. sty:T071 http://purl.bioontology.org/ontology/STY Entity A broad type for grouping physical and conceptual entities. sty:T072 http://purl.bioontology.org/ontology/STY Physical Object An object perceptible to the sense of vision or touch. sty:T073 http://purl.bioontology.org/ontology/STY Manufactured Object A physical object made by human beings. sty:T074 http://purl.bioontology.org/ontology/STY Medical Device A manufactured object used primarily in the diagnosis, treatment, or prevention of physiologic or anatomic disorders. sty:T075 http://purl.bioontology.org/ontology/STY Research Device A manufactured object used primarily in carrying out scientific research or experimentation. sty:T077 http://purl.bioontology.org/ontology/STY Conceptual Entity A broad type for grouping abstract entities or concepts. sty:T078 http://purl.bioontology.org/ontology/STY Idea or Concept An abstract concept, such as a social, religious or philosophical concept. sty:T079 http://purl.bioontology.org/ontology/STY Temporal Concept A concept which pertains to time or duration. sty:T080 http://purl.bioontology.org/ontology/STY Qualitative Concept A concept which is an assessment of some quality, rather than a direct measurement. sty:T081 http://purl.bioontology.org/ontology/STY Quantitative Concept A concept which involves the dimensions, quantity or capacity of something using some unit of measure, or which involves the quantitative comparison of entities. sty:T082 http://purl.bioontology.org/ontology/STY Spatial Concept A location, region, or space, generally having definite boundaries. sty:T083 http://purl.bioontology.org/ontology/STY Geographic Area A geographic location, generally having definite boundaries. sty:T085 http://purl.bioontology.org/ontology/STY Molecular Sequence A broad type for grouping the collected sequences of amino acids, carbohydrates, and nucleotide sequences. Descriptions of these sequences are generally reported in the published literature and/or are deposited in and maintained by databanks such as GenBank, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. sty:T086 http://purl.bioontology.org/ontology/STY Nucleotide Sequence The sequence of purines and pyrimidines in nucleic acids and polynucleotides. Included here are nucleotide-rich regions, conserved sequence, and DNA transforming region. sty:T087 http://purl.bioontology.org/ontology/STY Amino Acid Sequence The sequence of amino acids as arrayed in chains, sheets, etc., within the protein molecule. It is of fundamental importance in determining protein structure. sty:T088 http://purl.bioontology.org/ontology/STY Carbohydrate Sequence The sequence of carbohydrates within polysaccharides, glycoproteins, and glycolipids. sty:T089 http://purl.bioontology.org/ontology/STY Regulation or Law An intellectual product resulting from legislative or regulatory activity. sty:T090 http://purl.bioontology.org/ontology/STY Occupation or Discipline A vocation, academic discipline, or field of study, or a subpart of an occupation or discipline. sty:T091 http://purl.bioontology.org/ontology/STY Biomedical Occupation or Discipline A vocation, academic discipline, or field of study related to biomedicine. sty:T092 http://purl.bioontology.org/ontology/STY Organization The result of uniting for a common purpose or function. The continued existence of an organization is not dependent on any of its members, its location, or particular facility. Components or subparts of organizations are also included here. Although the names of organizations are sometimes used to refer to the buildings in which they reside, they are not inherently physical in nature. sty:T093 http://purl.bioontology.org/ontology/STY Health Care Related Organization An established organization which carries out specific functions related to health care delivery or research in the life sciences. sty:T094 http://purl.bioontology.org/ontology/STY Professional Society An organization uniting those who have a common vocation or who are involved with a common field of study. sty:T095 http://purl.bioontology.org/ontology/STY Self-help or Relief Organization An organization whose purpose and function is to provide assistance to the needy or to offer support to those sharing similar problems. sty:T096 http://purl.bioontology.org/ontology/STY Group A conceptual entity referring to the classification of individuals according to certain shared characteristics. sty:T097 http://purl.bioontology.org/ontology/STY Professional or Occupational Group An individual or individuals classified according to their vocation. sty:T098 http://purl.bioontology.org/ontology/STY Population Group An indivdual or individuals classified according to their sex, racial origin, religion, common place of living, financial or social status, or some other cultural or behavioral attribute. sty:T099 http://purl.bioontology.org/ontology/STY Family Group An individual or individuals classified according to their family relationships or relative position in the family unit. sty:T100 http://purl.bioontology.org/ontology/STY Age Group An individual or individuals classified according to their age. sty:T101 http://purl.bioontology.org/ontology/STY Patient or Disabled Group An individual or individuals classified according to a disability, disease, condition or treatment. sty:T102 http://purl.bioontology.org/ontology/STY Group Attribute A conceptual entity which refers to the frequency or distribution of certain characteristics or phenomena in certain groups. sty:T103 http://purl.bioontology.org/ontology/STY Chemical Compounds or substances of definite molecular composition. Chemicals are viewed from two distinct perspectives in the network, functionally and structurally. Almost every chemical concept is assigned at least two types, generally one from the structure hierarchy and at least one from the function hierarchy. sty:T104 http://purl.bioontology.org/ontology/STY Chemical Viewed Structurally A chemical or chemicals viewed from the perspective of their structural characteristics. Included here are concepts which can mean either a salt, an ion, or a compound (e.g., Bromates and Bromides). sty:T109 http://purl.bioontology.org/ontology/STY Organic Chemical The general class of carbon-containing compounds, usually based on carbon chains or rings, and also containing hydrogen (hydrocarbons), with or without nitrogen, oxygen, or other elements in which the bonding between elements is generally covalent. sty:T110 http://purl.bioontology.org/ontology/STY Steroid One of a group of polycyclic, 17-carbon-atom, fused-ring compounds occurring both in natural and synthetic forms. Included here are naturally occurring and synthetic steroids, bufanolides, cardanolides, homosteroids, norsteroids, and secosteroids. sty:T111 http://purl.bioontology.org/ontology/STY Eicosanoid An oxygenated metabolite from polyunsaturated 20 carbon fatty acids including lipoxygenase and cyclooxygenase products and their synthetic analogs. This includes the prostaglandins and thromboxanes. sty:T114 http://purl.bioontology.org/ontology/STY Nucleic Acid, Nucleoside, or Nucleotide A complex compound of high molecular weight occurring in living cells. These are basically of two types, ribonucleic (RNA) and deoxyribonucleic (DNA) acids. Nucleic acids are made of nucleotides (nitrogen-containing base, a 5-carbon sugar, and one or more phosphate group) linked together by a phosphodiester bond between the 5' and 3' carbon atoms. Nucleosides are compounds composed of a purine or pyrimidine base (usually adenine, cytosine, guanine, thymine, uracil) linked to either a ribose or a deoxyribose sugar. sty:T115 http://purl.bioontology.org/ontology/STY Organophosphorus Compound An organic compound containing phosphorus as a constituent. Included here are organic phosphinic, phosphonic and phosphoric acid derivatives and their thiophosphorus counterparts. Excluded are phospholipids, sugar phosphates, phosphoproteins, nucleotides, and nucleic acids. sty:T116 http://purl.bioontology.org/ontology/STY Amino Acid, Peptide, or Protein Amino acids and chains of amino acids connected by peptide linkages. sty:T118 http://purl.bioontology.org/ontology/STY Carbohydrate A generic term that includes monosaccharides, oligosaccharides, and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more terminal group to carboxylic acids, or by replacement of one or more hydroxy groups by a hydrogen atom, an amino group, a thiol group or similar heteroatomic groups. It also includes derivatives of these compounds. Included here are sugar phosphates. Excluded are glycolipids and glycoproteins. sty:T119 http://purl.bioontology.org/ontology/STY Lipid An inclusive group of fat or fat-derived substances that are soluble in nonpolar solvents related to fatty acid esters, fatty alcohols, sterols, waxes, etc. Included in this group are the saponifiable lipids such as glycerides (fats and oils), essential (volatile) oils, and phospholipids. sty:T120 http://purl.bioontology.org/ontology/STY Chemical Viewed Functionally A chemical viewed from the perspective of its functional characteristics or pharmacological activities. sty:T121 http://purl.bioontology.org/ontology/STY Pharmacologic Substance EuroCAT Umbrella Protocol for NSCLC A substance used in the treatment or prevention of pathologic disorders. This includes substances that occur naturally in the body and are administered therapeutically. sty:T122 http://purl.bioontology.org/ontology/STY Biomedical or Dental Material A substance used in biomedicine or dentistry predominantly for its physical, as opposed to chemical, properties. Included here are biocompatible materials, tissue adhesives, bone cements, resins, toothpastes, etc. sty:T123 http://purl.bioontology.org/ontology/STY Biologically Active Substance A generally endogenous substance produced or required by an organism, of primary interest because of its role in the biologic functioning of the organism that produces it. sty:T124 http://purl.bioontology.org/ontology/STY Neuroreactive Substance or Biogenic Amine An endogenous substance whose activities affect or play an important role in the functioning of the nervous system. Included here are catecholamines, neuroregulators, neurophysins, etc. sty:T125 http://purl.bioontology.org/ontology/STY Hormone In animals, a chemical usually secreted by an endocrine gland whose products are released into the circulating fluid. Hormones act as chemical messengers and regulate various physiologic processes such as growth, reproduction, metabolism, etc. They usually fall into two broad classes, steroid hormones and peptide hormones. sty:T126 http://purl.bioontology.org/ontology/STY Enzyme A complex chemical, usually a protein, that is produced by living cells and which catalyzes specific biochemical reactions. There are six main types of enzymes: oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases. sty:T127 http://purl.bioontology.org/ontology/STY Vitamin A substance, usually an organic chemical complex, present in natural products or made synthetically, which is essential in the diet of man or other higher animals. Included here are vitamin precursors, provitamins, and vitamin supplements. sty:T129 http://purl.bioontology.org/ontology/STY Immunologic Factor A biologically active substance whose activities affect or play a role in the functioning of the immune system. sty:T130 http://purl.bioontology.org/ontology/STY Indicator, Reagent, or Diagnostic Aid A substance primarily of interest for its use in laboratory or diagnostic tests and procedures to detect, measure, examine, or analyze other chemicals, processes, or conditions. sty:T131 http://purl.bioontology.org/ontology/STY Hazardous or Poisonous Substance A substance of concern because of its potentially hazardous or toxic effects. This would include most drugs of abuse, as well as agents that require special handling because of their toxicity. sty:T167 http://purl.bioontology.org/ontology/STY Substance A material with definite or fairly definite chemical composition. sty:T168 http://purl.bioontology.org/ontology/STY Food Any substance generally containing nutrients, such as carbohydrates, proteins, and fats, that can be ingested by a living organism and metabolized into energy and body tissue. Some foods are naturally occurring, others are either partially or entirely made by humans. sty:T169 http://purl.bioontology.org/ontology/STY Functional Concept A concept which is of interest because it pertains to the carrying out of a process or activity. sty:T170 http://purl.bioontology.org/ontology/STY Intellectual Product A conceptual entity resulting from human endeavor. Concepts assigned to this type generally refer to information created by humans for some purpose. sty:T171 http://purl.bioontology.org/ontology/STY Language The system of communication used by a particular nation or people. sty:T184 http://purl.bioontology.org/ontology/STY Sign or Symptom An observable manifestation of a disease or condition based on clinical judgment, or a manifestation of a disease or condition which is experienced by the patient and reported as a subjective observation. sty:T185 http://purl.bioontology.org/ontology/STY Classification A term or system of terms denoting an arrangement by class or category. sty:T190 http://purl.bioontology.org/ontology/STY Anatomical Abnormality An abnormal structure, or one that is abnormal in size or location. sty:T191 http://purl.bioontology.org/ontology/STY Neoplastic Process A new and abnormal growth of tissue in which the growth is uncontrolled and progressive. The growths may be malignant or benign. sty:T192 http://purl.bioontology.org/ontology/STY Receptor A specific structure or site on the cell surface or within its cytoplasm that recognizes and binds with other specific molecules. These include the proteins on the surface of an immunocompetent cell that binds with antigens, or proteins found on the surface molecules that bind with hormones or neurotransmitters and react with other molecules that respond in a specific way. sty:T194 http://purl.bioontology.org/ontology/STY Archaeon A member of one of the three domains of life, formerly called Archaebacteria under the taxon Bacteria, but now considered separate and distinct. Archaea are characterized by: 1) the presence of characteristic tRNAs and ribosomal RNAs; 2) the absence of peptidoglycan cell walls; 3) the presence of ether-linked lipids built from branched-chain subunits; and 4) their occurrence in unusual habitats. While archaea resemble bacteria in morphology and genomic organization, they resemble eukarya in their method of genomic replication. sty:T195 http://purl.bioontology.org/ontology/STY Antibiotic A pharmacologically active compound produced by growing microorganisms which kill or inhibit growth of other microorganisms. sty:T196 http://purl.bioontology.org/ontology/STY Element, Ion, or Isotope One of the 109 presently known fundamental substances that comprise all matter at and above the atomic level. This includes elemental metals, rare gases, and most abundant naturally occurring radioactive elements, as well as the ionic counterparts of elements (NA+, Cl-), and the less abundant isotopic forms. This does not include organic ions such as iodoacetate to which the type 'Organic Chemical' is assigned. sty:T197 http://purl.bioontology.org/ontology/STY Inorganic Chemical Chemical elements and their compounds, excluding the hydrocarbons and their derivatives (except carbides, carbonates, cyanides, cyanates and carbon disulfide). Generally inorganic compounds contain ionic bonds. Included here are inorganic acids and salts, alloys, alkalies, and minerals. sty:T200 http://purl.bioontology.org/ontology/STY Clinical Drug A pharmaceutical preparation as produced by the manufacturer. The name usually includes the substance, its strength, and the form, but may include the substance and only one of the other two items. sty:T201 http://purl.bioontology.org/ontology/STY Clinical Attribute An observable or measurable property or state of an organism of clinical interest. sty:T203 http://purl.bioontology.org/ontology/STY Drug Delivery Device A medical device that contains a clinical drug or drugs. sty:T204 http://purl.bioontology.org/ontology/STY Eukaryote One of the three domains of life (the others being Bacteria and Archaea), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including Animals, Plants, Fungi, various Algae, and other taxa that were previously part of the old kingdom Protista. UO:0000000 http://purl.bioontology.org/ontology/UO unit A unit of measurement is a standardized quantity of a physical quality. UO:0000001 http://purl.bioontology.org/ontology/UO length unit A unit which is a standard measure of the distance between two points. UO:0000002 http://purl.bioontology.org/ontology/UO mass unit A unit which is a standard measure of the amount of matter/energy of a physical object. UO:0000003 http://purl.bioontology.org/ontology/UO time unit A unit which is a standard measure of the dimension in which events occur in sequence. UO:0000009 http://purl.bioontology.org/ontology/UO kilogram A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France. UO:0000015 http://purl.bioontology.org/ontology/UO centimeter A length unit which is equal to one hundredth of a meter or 10^[-2] m. UO:0000033 http://purl.bioontology.org/ontology/UO day A time unit which is equal to 24 hours. UO:0000035 http://purl.bioontology.org/ontology/UO month A time unit which is approximately equal to the length of time of one of cycle of the moon's phases which in science is taken to be equal to 30 days. UO:0000036 http://purl.bioontology.org/ontology/UO year A time unit which is equal to 12 months which is science is taken to be equal to 365.25 days. UO:0000095 http://purl.bioontology.org/ontology/UO volume unit A unit which is a standard measure of the amount of space occupied by any substance, whether solid, liquid, or gas. UO:0000097 http://purl.bioontology.org/ontology/UO cubic centimeter A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml. UO:0000098 http://purl.bioontology.org/ontology/UO milliliter A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter. UO:0000099 http://purl.bioontology.org/ontology/UO Liter A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml. UO:0000127 http://purl.bioontology.org/ontology/UO radiation unit A unit which is a standard measure of the amount of radiation emitted by a given radiation source as well as the amount of radiation absorbed or deposited in a specific material by a radiation source. UO:0000134 http://purl.bioontology.org/ontology/UO gray An absorbed dose unit which is equal to the absorption of one joule of radiation energy by one kilogram of matter. UO:0000187 http://purl.bioontology.org/ontology/UO percent A dimensionless ratio unit which denotes numbers as fractions of 100. UO:0000189 http://purl.bioontology.org/ontology/UO count unit A dimensionless unit which denotes a simple count of things. ocre:OCRE200021 http://purl.bioontology.org/ontology/OCRE Interval censored The event occurred within an interval, but it is not known exactly when. Example: the last measurement day one person was HIV negative and the first measurement day the person was positive are known, but when the seroconversion happened within that interval is not known ocre:OCRE200064 http://purl.bioontology.org/ontology/OCRE Left censored The event occurred some time before the last measurement, but it is not known exactly when. Example: one person tests HIV positive, but there is no negative test result, so it is not possible to estalish a time interval for seroconversion ocre:OCRE200088 http://purl.bioontology.org/ontology/OCRE Censoring type Censoring type is a particular type of interval creation. Censoring means that one event prevents another event from being observed (e.g., end of study prevents possible evidence of success or failure from being observed). Though usually employed in the context of time-to-failure, this is not only about time, but it can be about any dimension of interest (e.g., if the measurement is above the maximum value in the scale used, then the measurement is right censored; if it is lower than the minimum detectable, then it is left censored). ocre:OCRE200105 http://purl.bioontology.org/ontology/OCRE Right censored The event my have occurred some time after the last measurement, but it is not known exactly whether it has, because there are no further observations. Example: one person tests HIV negative at some point, but there are no further observations (e.g., the individual moved, or died), so it is not known whether the person has seroconverted or not fma:fma10014 http://purl.bioontology.org/ontology/FMA Ninth thoracic vertebra fma:fma10037 http://purl.bioontology.org/ontology/FMA Tenth thoracic vertebra fma:fma10059 http://purl.bioontology.org/ontology/FMA Eleventh thoracic vertebra fma:fma10081 http://purl.bioontology.org/ontology/FMA Twelfth thoracic vertebra fma:fma10951 http://purl.bioontology.org/ontology/FMA Inferior vena cava Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium. fma:fma12513 http://purl.bioontology.org/ontology/FMA Eyeball Eye Globe Organ with organ cavity which is connected to the optic nerve. Examples: There are only two eyeballs, the right and the left eyeballs.. fma:fma12514 http://purl.bioontology.org/ontology/FMA Right eyeball fma:fma12515 http://purl.bioontology.org/ontology/FMA Left eyeball fma:fma12519 http://purl.bioontology.org/ontology/FMA Atlas fma:fma12520 http://purl.bioontology.org/ontology/FMA Axis fma:fma12521 http://purl.bioontology.org/ontology/FMA Third cervical vertebra fma:fma12522 http://purl.bioontology.org/ontology/FMA Fourth cervical vertebra fma:fma12523 http://purl.bioontology.org/ontology/FMA Fifth cervical vertebra fma:fma12524 http://purl.bioontology.org/ontology/FMA Sixth cervical vertebra fma:fma12525 http://purl.bioontology.org/ontology/FMA Seventh cervical vertebra fma:fma12526 http://purl.bioontology.org/ontology/FMA Sacral vertebra Sacrum Vertebrae fma:fma12784 http://purl.bioontology.org/ontology/FMA Esophageal lymph node EuroCAT Umbrella Protocol for NSCLC Station 8 N2 lymph node Station 8 lymph node fma:fma13072 http://purl.bioontology.org/ontology/FMA First lumbar vertebra fma:fma13073 http://purl.bioontology.org/ontology/FMA Second lumbar vertebra fma:fma13074 http://purl.bioontology.org/ontology/FMA Third lumbar vertebra fma:fma13075 http://purl.bioontology.org/ontology/FMA Fourth lumbar vertebra fma:fma13076 http://purl.bioontology.org/ontology/FMA Fifth lumbar vertebra fma:fma13077 http://purl.bioontology.org/ontology/FMA First sacral vertebra fma:fma13078 http://purl.bioontology.org/ontology/FMA Second sacral vertebra fma:fma13079 http://purl.bioontology.org/ontology/FMA Third sacral vertebra fma:fma13080 http://purl.bioontology.org/ontology/FMA Fourth sacral vertebra fma:fma13081 http://purl.bioontology.org/ontology/FMA Fifth sacral vertebra fma:fma13889 http://purl.bioontology.org/ontology/FMA Pituitary gland Pituitary fma:fma14192 http://purl.bioontology.org/ontology/FMA Supraclavicular lymph node EuroCAT Umbrella Protocol for NSCLC fma:fma14543 http://purl.bioontology.org/ontology/FMA Colon fma:fma14544 http://purl.bioontology.org/ontology/FMA Rectum fma:fma14626 http://purl.bioontology.org/ontology/FMA Wall of rectum Rectal Wall fma:fma15703 http://purl.bioontology.org/ontology/FMA Anal canal Organ with organ cavity which is continuous proximally with the rectum and distally terminates with the anus. Examples: There is only one anal canal. fma:fma15710 http://purl.bioontology.org/ontology/FMA Internal anal sphincter fma:fma15900 http://purl.bioontology.org/ontology/FMA Urinary bladder Organ with organ cavity which is continuous proximally with the right and left ureters and distally with the urethra. Examples: There is only one urinary bladder. fma:fma15902 http://purl.bioontology.org/ontology/FMA Wall of urinary bladder fma:fma16202 http://purl.bioontology.org/ontology/FMA Sacrum Bone complex which has as its direct parts five sacral vertebrae. fma:fma16580 http://purl.bioontology.org/ontology/FMA Bony pelvis fma:fma16950 http://purl.bioontology.org/ontology/FMA Pubic symphysis fma:fma17558 http://purl.bioontology.org/ontology/FMA Uterus Organ with organ cavity which is continuous proximally with the right and left uterine tubes and distally is connected to the vagina. Examples: There is only one uterus. fma:fma17740 http://purl.bioontology.org/ontology/FMA Cervix of uterus fma:fma19386 http://purl.bioontology.org/ontology/FMA Seminal vesicle fma:fma19387 http://purl.bioontology.org/ontology/FMA Right seminal vesicle fma:fma19388 http://purl.bioontology.org/ontology/FMA Left seminal vesicle fma:fma19614 http://purl.bioontology.org/ontology/FMA Bulb of penis Penile Bulb fma:fma19667 http://purl.bioontology.org/ontology/FMA Urethra Organ with organ cavity which connects the cavity of the urinary bladder to the exterior. Examples: There is only one urethra. fma:fma19949 http://purl.bioontology.org/ontology/FMA Vagina Organ with organ cavity which connects the cervical canal of uterus to the vestibule of vagina. Examples: There is only one vagina. fma:fma20462 http://purl.bioontology.org/ontology/FMA Vulva fma:fma20484 http://purl.bioontology.org/ontology/FMA Parametrium of body of uterus fma:fma21930 http://purl.bioontology.org/ontology/FMA External anal sphincter fma:fma232719 http://purl.bioontology.org/ontology/FMA Left supraclavicular lymph node EuroCAT Umbrella Protocol for NSCLC fma:fma232721 http://purl.bioontology.org/ontology/FMA Right supraclavicular lymph node EuroCAT Umbrella Protocol for NSCLC fma:fma24474 http://purl.bioontology.org/ontology/FMA Right femur fma:fma24475 http://purl.bioontology.org/ontology/FMA Left femur fma:fma25912 http://purl.bioontology.org/ontology/FMA Glenohumeral joint Glenohumeral Joint fma:fma25927 http://purl.bioontology.org/ontology/FMA Right glenohumeral joint fma:fma25929 http://purl.bioontology.org/ontology/FMA Left glenohumeral joint fma:fma26660 http://purl.bioontology.org/ontology/FMA Bronchial tree fma:fma26661 http://purl.bioontology.org/ontology/FMA Right bronchial tree fma:fma26662 http://purl.bioontology.org/ontology/FMA Left bronchial tree fma:fma275020 http://purl.bioontology.org/ontology/FMA Hippocampus fma:fma275022 http://purl.bioontology.org/ontology/FMA Right hippocampus fma:fma275024 http://purl.bioontology.org/ontology/FMA Left hippocampus fma:fma276813 http://purl.bioontology.org/ontology/FMA Aortopulmonary lymph node EuroCAT Umbrella Protocol for NSCLC Station 5 N2 lymph node Station 5 lymph node fma:fma276820 http://purl.bioontology.org/ontology/FMA Para-aortic thoracic lymph node EuroCAT Umbrella Protocol for NSCLC Station 6 N2 lymph node Station 6 lymph node fma:fma276828 http://purl.bioontology.org/ontology/FMA Interlobar lymph node EuroCAT Umbrella Protocol for NSCLC Station 11 N1 lymph node Station 11 lymph node fma:fma276849 http://purl.bioontology.org/ontology/FMA Lobar lymph node EuroCAT Umbrella Protocol for NSCLC Station 12 N1 lymph node Station 12 lymph node fma:fma276855 http://purl.bioontology.org/ontology/FMA Segmental lymph node EuroCAT Umbrella Protocol for NSCLC Station 13 N1 lymph node Station 13 lymph node fma:fma276861 http://purl.bioontology.org/ontology/FMA Subsegmental lymph node EuroCAT Umbrella Protocol for NSCLC Station 14 N1 lymph node Station 14 lymph node fma:fma276867 http://purl.bioontology.org/ontology/FMA Lymph node of inferior pulmonary ligament EuroCAT Umbrella Protocol for NSCLC Station 9 N2 lymph node Station 9 lymph node fma:fma276897 http://purl.bioontology.org/ontology/FMA Prevertebral lymph node EuroCAT Umbrella Protocol for NSCLC Station 3P N2 lymph node Station 3P lymph node fma:fma276907 http://purl.bioontology.org/ontology/FMA Pre-vascular lymph node EuroCAT Umbrella Protocol for NSCLC Station 3A N2 lymph node Station 3A lymph node fma:fma276928 http://purl.bioontology.org/ontology/FMA Highest mediastinal lymph node EuroCAT Umbrella Protocol for NSCLC Station 1 N2 lymph node Station 1 lymph node fma:fma276936 http://purl.bioontology.org/ontology/FMA Right upper paratracheal lymph node EuroCAT Umbrella Protocol for NSCLC Right station 2 N2 lymph node Right station 2 lymph node fma:fma276938 http://purl.bioontology.org/ontology/FMA Left upper paratracheal lymph node EuroCAT Umbrella Protocol for NSCLC Left station 2 N2 lymph node Left station 2 lymph node fma:fma321496 http://purl.bioontology.org/ontology/FMA Right breast fma:fma321497 http://purl.bioontology.org/ontology/FMA Left breast fma:fma323954 http://purl.bioontology.org/ontology/FMA Mesorectal lymph node group fma:fma35178 http://purl.bioontology.org/ontology/FMA Hip joint Femoral Joint fma:fma35179 http://purl.bioontology.org/ontology/FMA Right hip joint fma:fma35180 http://purl.bioontology.org/ontology/FMA Left hip joint fma:fma3734 http://purl.bioontology.org/ontology/FMA Aorta fma:fma3932 http://purl.bioontology.org/ontology/FMA Brachiocephalic artery Brachiocephalic Artery fma:fma3939 http://purl.bioontology.org/ontology/FMA Common carotid artery fma:fma3941 http://purl.bioontology.org/ontology/FMA Right common carotid artery fma:fma3951 http://purl.bioontology.org/ontology/FMA Subclavian artery Subclavicular Artery Systemic artery the trunk of which is continuous with either the trunk of brachiocephalic artery on the right side, or the aorta on the left side. fma:fma3953 http://purl.bioontology.org/ontology/FMA Right subclavian artery Subclavian artery the trunk of which is continuous with trunk of brachiocephalic artery. fma:fma4058 http://purl.bioontology.org/ontology/FMA Left common carotid artery fma:fma45244 http://purl.bioontology.org/ontology/FMA Right brachial nerve plexus fma:fma45245 http://purl.bioontology.org/ontology/FMA Left brachial nerve plexus fma:fma46620 http://purl.bioontology.org/ontology/FMA Constrictor muscle of pharynx fma:fma46688 http://purl.bioontology.org/ontology/FMA Pharynx fma:fma4694 http://purl.bioontology.org/ontology/FMA Left subclavian artery fma:fma4720 http://purl.bioontology.org/ontology/FMA Superior vena cava Trunk of systemic vein which is formed by the union of the right and left brachiocephalic veins and terminates in the right atrium. fma:fma4725 http://purl.bioontology.org/ontology/FMA Subclavian vein SubClavicular Vein fma:fma4755 http://purl.bioontology.org/ontology/FMA Right subclavian vein fma:fma4763 http://purl.bioontology.org/ontology/FMA Left subclavian vein fma:fma4838 http://purl.bioontology.org/ontology/FMA Azygos vein fma:fma48996 http://purl.bioontology.org/ontology/FMA Masseter fma:fma48997 http://purl.bioontology.org/ontology/FMA Right masseter fma:fma48998 http://purl.bioontology.org/ontology/FMA Left masseter fma:fma49182 http://purl.bioontology.org/ontology/FMA Oral cavity proper fma:fma49846 http://purl.bioontology.org/ontology/FMA Inferior hypophysial artery fma:fma49847 http://purl.bioontology.org/ontology/FMA Right inferior hypophyseal artery fma:fma49848 http://purl.bioontology.org/ontology/FMA Left inferior hypophyseal artery fma:fma49849 http://purl.bioontology.org/ontology/FMA Superior hypophysial artery fma:fma49850 http://purl.bioontology.org/ontology/FMA Right superior hypophyseal artery fma:fma49851 http://purl.bioontology.org/ontology/FMA Left superior hypophyseal artery fma:fma49893 http://purl.bioontology.org/ontology/FMA Coronary artery Systemic artery which supplies the heart. fma:fma49908 http://purl.bioontology.org/ontology/FMA Superior pulmonary vein fma:fma49910 http://purl.bioontology.org/ontology/FMA Inferior pulmonary vein fma:fma49911 http://purl.bioontology.org/ontology/FMA Right inferior pulmonary vein fma:fma49913 http://purl.bioontology.org/ontology/FMA Left inferior pulmonary vein fma:fma49914 http://purl.bioontology.org/ontology/FMA Right superior pulmonary vein fma:fma49916 http://purl.bioontology.org/ontology/FMA Left superior pulmonary vein fma:fma50039 http://purl.bioontology.org/ontology/FMA Right coronary artery Coronary artery which emerges from the anterior aortic sinus, between the right auricle and the pulmonary trunk, and supplies the right side of the heart. fma:fma50040 http://purl.bioontology.org/ontology/FMA Left coronary artery Coronary artery which emerges from the left posterior aortic sinus, between the left auricle and the pulmonary trunk, and supplies the left side of the heart. fma:fma5034 http://purl.bioontology.org/ontology/FMA Lymph node Organ component of lymphatic tree organ which has as direct regional parts cortex and medulla. fma:fma50801 http://purl.bioontology.org/ontology/FMA Brain Segment of neuraxis which consists of portion of neural tissue organized and subdivided into forebrain, midbrain and hindbrain, contained in cranial cavity and continuous with and rostral to spinal cord. fma:fma50863 http://purl.bioontology.org/ontology/FMA Optic nerve Nerve trunk which is continuous with the retina and the optic chiasm. fma:fma50864 http://purl.bioontology.org/ontology/FMA Oculomotor nerve Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles. fma:fma50865 http://purl.bioontology.org/ontology/FMA Trochlear nerve fma:fma50866 http://purl.bioontology.org/ontology/FMA Trigeminal nerve fma:fma50867 http://purl.bioontology.org/ontology/FMA Abducens nerve fma:fma50868 http://purl.bioontology.org/ontology/FMA Facial nerve Seventh Cranial Nerve fma:fma50869 http://purl.bioontology.org/ontology/FMA Vestibulocochlear nerve Eighth Cranial Nerve fma:fma50870 http://purl.bioontology.org/ontology/FMA Glossopharyngeal nerve fma:fma50871 http://purl.bioontology.org/ontology/FMA Hypoglossal nerve fma:fma50872 http://purl.bioontology.org/ontology/FMA Right pulmonary artery fma:fma50873 http://purl.bioontology.org/ontology/FMA Left pulmonary artery fma:fma50875 http://purl.bioontology.org/ontology/FMA Right optic nerve Optic nerve which is continuous with the right retina and the optic chiasm. fma:fma50878 http://purl.bioontology.org/ontology/FMA Left optic nerve Optic nerve which is continuous with the left retina and the optic chiasm. fma:fma50888 http://purl.bioontology.org/ontology/FMA Right facial nerve fma:fma50889 http://purl.bioontology.org/ontology/FMA Left facial nerve fma:fma50890 http://purl.bioontology.org/ontology/FMA Right vestibulocochlear nerve fma:fma50891 http://purl.bioontology.org/ontology/FMA Left vestibulocochlear nerve fma:fma52590 http://purl.bioontology.org/ontology/FMA Cauda equina fma:fma52748 http://purl.bioontology.org/ontology/FMA Mandible fma:fma52781 http://purl.bioontology.org/ontology/FMA External ear Subdivision of auriculotemporal part of head which has its direct parts pinna and external acoustic tube. Examples: Ther are only two external ears. fma:fma53643 http://purl.bioontology.org/ontology/FMA Right external ear fma:fma53644 http://purl.bioontology.org/ontology/FMA Left external ear fma:fma54448 http://purl.bioontology.org/ontology/FMA Eye Subdivision of face which has as its direct parts orbital cavity and its content and eyelids. fma:fma54449 http://purl.bioontology.org/ontology/FMA Right eye fma:fma54450 http://purl.bioontology.org/ontology/FMA Left eye fma:fma54640 http://purl.bioontology.org/ontology/FMA Tongue fma:fma54645 http://purl.bioontology.org/ontology/FMA Posterior part of tongue Base of tongue fma:fma54832 http://purl.bioontology.org/ontology/FMA Temporomandibular joint Temperomandibular Joint fma:fma54833 http://purl.bioontology.org/ontology/FMA Right temporomandibular joint fma:fma54834 http://purl.bioontology.org/ontology/FMA Left temporomandibular joint fma:fma55093 http://purl.bioontology.org/ontology/FMA Submandibular gland fma:fma55097 http://purl.bioontology.org/ontology/FMA Larynx Heterogeneous cluster that connects the pharynx to the tracheobronchial tree. Examples: There is only one larynx. fma:fma55269 http://purl.bioontology.org/ontology/FMA Segment of esophagus Organ segment which is regional part of esophagus. Examples: cervical part of esophagus, vertebral segment of esophagus. fma:fma55414 http://purl.bioontology.org/ontology/FMA Glottis Subdivision of the larynx which consists of the right and left vocal cords and the rima glottidis. Examples: There is only one glottis. fma:fma56513 http://purl.bioontology.org/ontology/FMA Middle ear fma:fma56514 http://purl.bioontology.org/ontology/FMA Right middle ear fma:fma56515 http://purl.bioontology.org/ontology/FMA Left middle ear fma:fma5731 http://purl.bioontology.org/ontology/FMA Vagus nerve fma:fma58238 http://purl.bioontology.org/ontology/FMA Cornea fma:fma58239 http://purl.bioontology.org/ontology/FMA Right cornea fma:fma58240 http://purl.bioontology.org/ontology/FMA Left cornea fma:fma58241 http://purl.bioontology.org/ontology/FMA Lens Eye Lens fma:fma58242 http://purl.bioontology.org/ontology/FMA Right lens fma:fma58243 http://purl.bioontology.org/ontology/FMA Left lens fma:fma58301 http://purl.bioontology.org/ontology/FMA Retina Layer of wall of eyeball which is continuous with optic nerve. fma:fma58302 http://purl.bioontology.org/ontology/FMA Right retina Layer of wall of right eyeball which is continuous with right optic nerve. fma:fma58303 http://purl.bioontology.org/ontology/FMA Left retina Layer of wall of left eyeball which is continuous with left optic nerve. fma:fma5865 http://purl.bioontology.org/ontology/FMA Cranial nerve Neural tree organ which is continuous with the brain. Examples: Trochlear nerve, facial nerve. fma:fma5906 http://purl.bioontology.org/ontology/FMA Brachial nerve plexus fma:fma59101 http://purl.bioontology.org/ontology/FMA Lacrimal gland Lobular organ the parenchyma of which consists of glandular acini which communicate the lacrimal sac. Examples: There only two, right lacrimal and left lacrimal glands. fma:fma59102 http://purl.bioontology.org/ontology/FMA Right lacrimal gland fma:fma59103 http://purl.bioontology.org/ontology/FMA Left lacrimal gland fma:fma5960 http://purl.bioontology.org/ontology/FMA Right superior tracheobronchial lymph node EuroCAT Umbrella Protocol for NSCLC Right station 4 N2 lymph node Right station 4 lymph node fma:fma5961 http://purl.bioontology.org/ontology/FMA Left superior tracheobronchial lymph node EuroCAT Umbrella Protocol for NSCLC Left station 4 N2 lymph node Left station 4 lymph node fma:fma5962 http://purl.bioontology.org/ontology/FMA Inferior tracheobronchial lymph node EuroCAT Umbrella Protocol for NSCLC Station 7 N2 lymph node Station 7 lymph node fma:fma5965 http://purl.bioontology.org/ontology/FMA Bronchopulmonary lymph node EuroCAT Umbrella Protocol for NSCLC Station 10 N1 lymph node Station 10 lymph node fma:fma59790 http://purl.bioontology.org/ontology/FMA Parotid gland Parotid fma:fma59797 http://purl.bioontology.org/ontology/FMA Right parotid gland fma:fma59798 http://purl.bioontology.org/ontology/FMA Left parotid gland fma:fma59802 http://purl.bioontology.org/ontology/FMA Right submandibular gland fma:fma59803 http://purl.bioontology.org/ontology/FMA Left submandibular gland fma:fma59816 http://purl.bioontology.org/ontology/FMA Lip Region of labial part of mouth sharing upper or lower boundary of oral orifice. fma:fma60201 http://purl.bioontology.org/ontology/FMA Cochlea fma:fma60202 http://purl.bioontology.org/ontology/FMA Right cochlea fma:fma60203 http://purl.bioontology.org/ontology/FMA Left cochlea fma:fma61817 http://purl.bioontology.org/ontology/FMA Cerebral hemisphere Cerebrum Segment of telencephalon which has as its direct proper parts cerebral cortex and cerebral medulla. fma:fma61819 http://purl.bioontology.org/ontology/FMA Left cerebral hemisphere Left cerebral hemisphere is one of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter. fma:fma61824 http://purl.bioontology.org/ontology/FMA Frontal lobe Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border. fma:fma61825 http://purl.bioontology.org/ontology/FMA Temporal lobe Temporal lobe is the ventrolateral lobe of five lobes comprising each cerebral hemisphere. It is bounded dorsally by the lateral fissure and posteriorly by an arbitrary border shared with the occipital lobe. fma:fma61826 http://purl.bioontology.org/ontology/FMA Parietal lobe Parietal lobe is the one of five lobes of the cerebral hemisphere which occupies the dorsal-posterior portion of the hemisphere. It is bounded by the central sulcus on its anterior border and and by the longitudinal cerebral fissure on its medial border. Posteriorly it shares an arbitrary border with the occipital lobe. fma:fma62008 http://purl.bioontology.org/ontology/FMA Hypothalamus fma:fma62045 http://purl.bioontology.org/ontology/FMA Optic chiasm Nerve trunk which is continuous with right and left optic nerves and right and left optic tracts. fma:fma63183 http://purl.bioontology.org/ontology/FMA Blood vessel Segment of blood vessel tree organ which is a tubular structure the lumen of which contains blood; together with other spatially associated blood vessels constitute blood vessel tree organ. fma:fma66326 http://purl.bioontology.org/ontology/FMA Pulmonary artery fma:fma66643 http://purl.bioontology.org/ontology/FMA Pulmonary vein Vein in the pulmonary vemnous system. fma:fma67292 http://purl.bioontology.org/ontology/FMA Right cerebral hemisphere The right cerebral hemisphere is one of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter. fma:fma67325 http://purl.bioontology.org/ontology/FMA Occipital lobe Occipital lobe is the one of five lobes of the cerebral hemisphere which occupies the posterior-most portion of the hemisphere. Anteriorly, it shares an arbitrary border with the parietal lobe and temporal lobe. Medially, it is bounded by the longitudinal cerebral fissure. fma:fma67944 http://purl.bioontology.org/ontology/FMA Cerebellum Segment of neuraxis that has as its parts the cerebellar cortex, cerebellar nuclear complex and cerebellar white matter. Examples: There is only one cerebellum. fma:fma70776 http://purl.bioontology.org/ontology/FMA Lymph node group Set of organ components of lymphatic tree organ consisting of lymph nodes without connecting lymphatic vessels. fma:fma7088 http://purl.bioontology.org/ontology/FMA Heart Organ with cavitated organ parts, which is continuous with the systemic and pulmonary arterial and venous trees. Examples: There is only one heart. fma:fma7096 http://purl.bioontology.org/ontology/FMA Right atrium Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava. fma:fma7097 http://purl.bioontology.org/ontology/FMA Left atrium Left cardiac chamber which is continuous with the pulmonary venous trunk. fma:fma7098 http://purl.bioontology.org/ontology/FMA Right ventricle Right cardiac chamber which is continuous with the pulmonary arterial trunk. fma:fma7099 http://purl.bioontology.org/ontology/FMA Cardiac atrium Cardiac chamber which consists of a wall that surrounds the cavity of an atrium. fma:fma7100 http://purl.bioontology.org/ontology/FMA Cardiac ventricle Cardiac chamber which consists of a wall that surrounds the cavity of a ventricle. fma:fma7101 http://purl.bioontology.org/ontology/FMA Left ventricle Left cardiac chamber which is continuous with the aorta. fma:fma7131 http://purl.bioontology.org/ontology/FMA Esophagus Organ with organ cavity which is continuous superiorly with the pharynx and inferiorly with the stomach. Examples: There is only one esophagus. fma:fma7148 http://purl.bioontology.org/ontology/FMA Stomach Organ with organ cavity which is continuous proximally with the esophagus and distally with the small intestine. Examples: There is only one stomach. fma:fma7163 http://purl.bioontology.org/ontology/FMA Skin Nonparenchymatous organ that consists of the epidermis, dermis and sets of hair and nails and which surrounds the entire body. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body. Examples: There is only one skin. fma:fma7195 http://purl.bioontology.org/ontology/FMA Lung Lobular organ which has as its parts alveoli connected to the tracheobronchial tree. Examples: There are only two lungs, right lung and left lung. fma:fma7196 http://purl.bioontology.org/ontology/FMA Spleen fma:fma7197 http://purl.bioontology.org/ontology/FMA Liver Lobular organ which has as its parts lobules connected to the biliary tree. Examples: There is only one liver. fma:fma7198 http://purl.bioontology.org/ontology/FMA Pancreas Lobular organ the parenchyma of which consists of glandular acini which communicate via a duct system with the duodenum. Examples: There is only one pancreas. fma:fma7200 http://purl.bioontology.org/ontology/FMA Small intestine Small Bowel Organ with organ cavity which is continuous proximally with the stomach and distally with the large intestine. Examples: There is only one small intestine. fma:fma7201 http://purl.bioontology.org/ontology/FMA Large intestine Large Bowel Organ with organ cavity which is continuous proximally with the small intestine and distally with the anal canal. Examples: There is only large intestine. fma:fma7203 http://purl.bioontology.org/ontology/FMA Kidney Corticomedullary organ which has as its part renal pelvis shared with and connected to ureter. Examples: There are only two, right kidney and left kidney. fma:fma7204 http://purl.bioontology.org/ontology/FMA Right kidney Kidney located right of sagittal midplane of body. fma:fma7205 http://purl.bioontology.org/ontology/FMA Left kidney Kidney located left of sagittal midplane of body. fma:fma7206 http://purl.bioontology.org/ontology/FMA Duodenum fma:fma7209 http://purl.bioontology.org/ontology/FMA Ovary fma:fma7210 http://purl.bioontology.org/ontology/FMA Testis Lobular organ the parenchyma of which consists of seminiferous tubules which communicate with the duct of the epididymis. Examples: There only two, right testis and left testis. fma:fma7211 http://purl.bioontology.org/ontology/FMA Right testis Testis located right of sagittal midplane of body. fma:fma7212 http://purl.bioontology.org/ontology/FMA Left testis Testis located left of sagittal midplane of body. fma:fma7213 http://purl.bioontology.org/ontology/FMA Right ovary fma:fma7214 http://purl.bioontology.org/ontology/FMA Left ovary fma:fma72969 http://purl.bioontology.org/ontology/FMA Right frontal lobe fma:fma72970 http://purl.bioontology.org/ontology/FMA Left frontal lobe fma:fma72971 http://purl.bioontology.org/ontology/FMA Right temporal lobe fma:fma72972 http://purl.bioontology.org/ontology/FMA Left temporal lobe fma:fma72973 http://purl.bioontology.org/ontology/FMA Right parietal lobe fma:fma72974 http://purl.bioontology.org/ontology/FMA Left parietal lobe fma:fma72975 http://purl.bioontology.org/ontology/FMA Right occipital lobe fma:fma72976 http://purl.bioontology.org/ontology/FMA Left occipital lobe fma:fma7309 http://purl.bioontology.org/ontology/FMA Right lung Lung located right of sagittal midplane of body and which consists of the right upper lobe, middle lobe and right lower lobe. fma:fma7310 http://purl.bioontology.org/ontology/FMA Left lung Lung located left of sagittal midplane of body and which consists of the left upper lobe and left lower lobe. fma:fma7311 http://purl.bioontology.org/ontology/FMA Lobe of lung EuroCAT Umbrella Protocol for NSCLC fma:fma7330 http://purl.bioontology.org/ontology/FMA Pulmonary hilum fma:fma7333 http://purl.bioontology.org/ontology/FMA Upper lobe of right lung EuroCAT Umbrella Protocol for NSCLC fma:fma7334 http://purl.bioontology.org/ontology/FMA Upper lobe of lung EuroCAT Umbrella Protocol for NSCLC fma:fma7335 http://purl.bioontology.org/ontology/FMA Lower lobe of lung EuroCAT Umbrella Protocol for NSCLC fma:fma7337 http://purl.bioontology.org/ontology/FMA Lower lobe of right lung EuroCAT Umbrella Protocol for NSCLC fma:fma7370 http://purl.bioontology.org/ontology/FMA Upper lobe of left lung EuroCAT Umbrella Protocol for NSCLC fma:fma7371 http://purl.bioontology.org/ontology/FMA Lower lobe of left lung EuroCAT Umbrella Protocol for NSCLC fma:fma7383 http://purl.bioontology.org/ontology/FMA Middle lobe of right lung EuroCAT Umbrella Protocol for NSCLC fma:fma7394 http://purl.bioontology.org/ontology/FMA Trachea fma:fma7395 http://purl.bioontology.org/ontology/FMA Right main bronchus fma:fma7396 http://purl.bioontology.org/ontology/FMA Left main bronchus fma:fma7405 http://purl.bioontology.org/ontology/FMA Main bronchus fma:fma7433 http://purl.bioontology.org/ontology/FMA Lingula of left lung fma:fma7456 http://purl.bioontology.org/ontology/FMA Right pulmonary hilum fma:fma7465 http://purl.bioontology.org/ontology/FMA Carina of trachea fma:fma7480 http://purl.bioontology.org/ontology/FMA Rib cage fma:fma7574 http://purl.bioontology.org/ontology/FMA Rib fma:fma7592 http://purl.bioontology.org/ontology/FMA True rib fma:fma7593 http://purl.bioontology.org/ontology/FMA Typical rib fma:fma7594 http://purl.bioontology.org/ontology/FMA False rib fma:fma7595 http://purl.bioontology.org/ontology/FMA Floating rib fma:fma7596 http://purl.bioontology.org/ontology/FMA Atypical rib fma:fma7597 http://purl.bioontology.org/ontology/FMA First rib fma:fma7620 http://purl.bioontology.org/ontology/FMA Second rib fma:fma7638 http://purl.bioontology.org/ontology/FMA Third rib fma:fma7647 http://purl.bioontology.org/ontology/FMA Spinal cord Segment of neuraxis which consists of portion of neural tissue continuous with and caudal to brain, surround central canal and contained in space of vertebral canal. fma:fma7749 http://purl.bioontology.org/ontology/FMA Fourth rib fma:fma7776 http://purl.bioontology.org/ontology/FMA Fifth rib fma:fma7830 http://purl.bioontology.org/ontology/FMA Seventh rib fma:fma7857 http://purl.bioontology.org/ontology/FMA Right first rib fma:fma7882 http://purl.bioontology.org/ontology/FMA Right second rib fma:fma7909 http://purl.bioontology.org/ontology/FMA Right third rib fma:fma7957 http://purl.bioontology.org/ontology/FMA Right fourth rib fma:fma7987 http://purl.bioontology.org/ontology/FMA Left first rib fma:fma79876 http://purl.bioontology.org/ontology/FMA Brainstem fma:fma8012 http://purl.bioontology.org/ontology/FMA Left second rib fma:fma8039 http://purl.bioontology.org/ontology/FMA Left third rib fma:fma8066 http://purl.bioontology.org/ontology/FMA Right fifth rib fma:fma8093 http://purl.bioontology.org/ontology/FMA Left fifth rib fma:fma8120 http://purl.bioontology.org/ontology/FMA Eighth rib fma:fma8147 http://purl.bioontology.org/ontology/FMA Sixth rib fma:fma8148 http://purl.bioontology.org/ontology/FMA Left fourth rib fma:fma8175 http://purl.bioontology.org/ontology/FMA Right sixth rib fma:fma8202 http://purl.bioontology.org/ontology/FMA Left sixth rib fma:fma8229 http://purl.bioontology.org/ontology/FMA Right seventh rib fma:fma8256 http://purl.bioontology.org/ontology/FMA Left seventh rib fma:fma8283 http://purl.bioontology.org/ontology/FMA Right eighth rib fma:fma8310 http://purl.bioontology.org/ontology/FMA Left eighth rib fma:fma8337 http://purl.bioontology.org/ontology/FMA Ninth rib fma:fma8364 http://purl.bioontology.org/ontology/FMA Right ninth rib fma:fma8391 http://purl.bioontology.org/ontology/FMA Left ninth rib fma:fma8418 http://purl.bioontology.org/ontology/FMA Tenth rib fma:fma8445 http://purl.bioontology.org/ontology/FMA Right tenth rib fma:fma8472 http://purl.bioontology.org/ontology/FMA Left tenth rib fma:fma8499 http://purl.bioontology.org/ontology/FMA Eleventh rib fma:fma8515 http://purl.bioontology.org/ontology/FMA Twelfth rib fma:fma8531 http://purl.bioontology.org/ontology/FMA Right eleventh rib fma:fma8532 http://purl.bioontology.org/ontology/FMA Left eleventh rib fma:fma8533 http://purl.bioontology.org/ontology/FMA Right twelfth rib fma:fma8534 http://purl.bioontology.org/ontology/FMA Left twelfth rib fma:fma9139 http://purl.bioontology.org/ontology/FMA Thoracic vertebra fma:fma9165 http://purl.bioontology.org/ontology/FMA First thoracic vertebra fma:fma9187 http://purl.bioontology.org/ontology/FMA Second thoracic vertebra fma:fma9209 http://purl.bioontology.org/ontology/FMA Third thoracic vertebra fma:fma9248 http://purl.bioontology.org/ontology/FMA Fourth thoracic vertebra fma:fma9579 http://purl.bioontology.org/ontology/FMA Perineum Subdivision of trunk proper, which is demarcated from the pelvis by the inferior surface of the pelvic diaphragm and from the lower limbs by the perineofemoral lines; together with the thorax, and abdomen, it constitutes the trunk proper. Examples: There is only one perineum. fma:fma9597 http://purl.bioontology.org/ontology/FMA Salivary gland Lobular organ the parenchyma of which consists of glandular acini which communicate with oral cavity. Examples: parotid gland, sublingual gland, lingual salivary gland. fma:fma9600 http://purl.bioontology.org/ontology/FMA Prostate Prostate Lobular organ the parenchyma of which has as its parts glandular acini which are continuous with the prostatic part of the urethra. Examples: There is only one prostate. fma:fma9601 http://purl.bioontology.org/ontology/FMA Breast Region of pectoral part of chest which has as its parts nipple, areola, breast proper. fma:fma9603 http://purl.bioontology.org/ontology/FMA Thyroid gland Thyroid Lobular organ the parenchyma of which consists of ductless, glandular follicles filled with colloid. Examples: thyroid gland proper, accessory thyroid gland, lingual thyroid gland. fma:fma9611 http://purl.bioontology.org/ontology/FMA Femur fma:fma9707 http://purl.bioontology.org/ontology/FMA Penis fma:fma9751 http://purl.bioontology.org/ontology/FMA Left pulmonary hilum fma:fma9826 http://purl.bioontology.org/ontology/FMA Mediastinum Subdivsion of thoracic compartment which has as its parts the superior mediastinum and inferior mediastinum. fma:fma9869 http://purl.bioontology.org/ontology/FMA Pericardium Organ cluster which has as its direct parts the fibrous pericardium and the pericardial sac. fma:fma9915 http://purl.bioontology.org/ontology/FMA Cervical vertebra fma:fma9921 http://purl.bioontology.org/ontology/FMA Lumbar vertebra fma:fma9922 http://purl.bioontology.org/ontology/FMA Fifth thoracic vertebra fma:fma9945 http://purl.bioontology.org/ontology/FMA Sixth thoracic vertebra fma:fma9968 http://purl.bioontology.org/ontology/FMA Seventh thoracic vertebra fma:fma9991 http://purl.bioontology.org/ontology/FMA Eighth thoracic vertebra dcm:InformationEntity http://purl.bioontology.org/ontology/SEDI InformationEntity dcm:InformationObjectDefinition InformationObjectDefinition An Information Object Definition (IOD) is an object-oriented abstract data model used to specify information about Real-World Objects. An IOD provides communicating Application Entities with a common view of the information to be exchanged. (DICOM) dcm:Patient http://purl.bioontology.org/ontology/SEDI Patient dcm:RTDose RTDose dcm:RTImage RTImage dcm:RTPlan RTPlan dcm:RTStructureSet RTStructureSet dcm:Series http://purl.bioontology.org/ontology/SEDI Series dcm:Study http://purl.bioontology.org/ontology/SEDI Study C000000 Andre Dekker Two or More Years Survival Elapsed time two or more years that a person has been alive since a related observation, procedure, event or finding. C000001 Andre Dekker Less Than Two Years Survival Elapsed time is less than two years that a person has been alive since a related observation, procedure, event or finding. The person has died. C100001 Andre Dekker Adult comorbidity evaluation-27 The Adult Comorbidity Evaluation - 27 is a 27-item comorbidity index for patients with cancer. It identifies the important medical comorbidities and grades severity using the index. For more information: https://www.rtog.org/LinkClick.aspx?fileticket=xMGEfaLHRuM%3D&tabid=290. C100002 Andre Dekker 'Age at Diagnosis' Age at Diagnosis Age at the time of diagnosis of the disease. C100003 Andre Dekker Age at Start RT EuroCAT Umbrella Protocol for NSCLC The age of the patient at the start of radiotherapy. C100006 Andre Dekker GTV (ROI) A region of interest based on a delineation of the Gross Tumor Volume. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100007 Andre Dekker PTV (ROI) A region of interest based on a delineation of the Planning Target Volume. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100009 Andre Dekker SUVmax The maximum tracer uptake in a given region of interest calculated standardized using the bdy weight and the injected activity. C100010 Andre Dekker SUVmean The mean tracer uptake in a given region of interest calculated standardized using the bdy weight and the injected activity. C100011 Andre Dekker Delivered Radiotherapy Total Treatment Dose The total absorbed radiation dose delivered to a tumor in a complete radiotherapy treatment. C100012 Andre Dekker Delivered Radiation Dose The absorbed radiation dose actually delivered to a tissue. C100013 Andre Dekker Prescribed Radiation Dose The absorbed radiation dose prescribed to be delivered to a tissue. C100014 Andre Dekker Survival Elapsed time that a person has been alive since a related observation, procedure, event or finding. C100043 Andre Dekker Sequential Chemoradiotherapy EuroCAT Umbrella Protocol for NSCLC Chemotherapy given before and/or after radiotherapy. C100044 Andre Dekker Living with partner EuroCAT Umbrella Protocol for NSCLC The social circumstance where a persons lives with a partner in a romantic relantionship. C100045 Andre Dekker Cause of death related to cancer The circumstance or condition that resulted in the death of a living being was related to cancer. C100046 Andre Dekker Cause of death directly related to cancer The circumstance or condition that resulted in the death of a living being was directly related to cancer. An example is death due to respiratory failure cause by metastases in the lung. C100047 Andre Dekker Cause of death indirectly related to cancer The circumstance or condition that resulted in the death of a living being was directly related to cancer. An example is death due to respiratory failure cause by radiation pneuomnitis after lung cancer radiotherapy. C100048 Andre Dekker Cause of death not related to cancer The circumstance or condition that resulted in the death of a living being was not related to cancer. C100049 Andre Dekker Positive Lymph Node Stations EuroCAT Umbrella Protocol for NSCLC Number of positive lymph node stations (PLNS), assessed by FDG-PET scan, using the Naruke map. C100050 Andre Dekker Number of Images The count of images in a given image set. C100051 Andre Dekker AJCC Edition Edition of the American Joint Commission on Cancer (AJCC) Cancer Staging Manual. C100052 Andre Dekker AJCC 7th Edition EuroCAT Umbrella Protocol for NSCLC Seventh edition of the American Joint Commission on Cancer (AJCC) Cancer Staging Manual. C100053 Andre Dekker AJCC 6th Edition Sixth edition of the American Joint Commission on Cancer (AJCC) Cancer Staging Manual. C100054 Andre Dekker Volume of the Primary Tumor EuroCAT Umbrella Protocol for NSCLC The volume of the primary tumor. C100055 Andre Dekker Volume of the Positive Macroscopic Nodes EuroCAT Umbrella Protocol for NSCLC The total volume of all macroscopic lymph nodes metastases in the body. C100056 Andre Dekker Radiotherapy Fraction A therapeutic procedure or session in which part of the full radiotherapy course is delivered. Commonly radiotherapy is given in daily fractions. This allows healthy cells to recover between fractions. C100057 Andre Dekker Prescribed Radiotherapy Total Treatment Dose The total absorbed radiation dose prescribed to a tumor in a complete radiotherapy treatment. C100058 Andre Dekker First Radiotherapy fraction The first fraction of a radiotherapy treatment. C100059 Andre Dekker Last Radiotherapy fraction The last fraction of a radiotherapy treatment. C100060 Andre Dekker Person Identifier An identifier which is used to uniquely identify a person in a certain context (cohort, hospital, trial). Can be a pseudonym. C100062 Andre Dekker Living alone EuroCAT Umbrella Protocol for NSCLC The social circumstance where a persons lives alone. C100063 Andre Dekker Survival Time Since First Treatment Time elapsed between time of fist treatment and the patient's time of death. C100064 Andre Dekker Multiple Lobes of the Lung EuroCAT Umbrella Protocol for NSCLC An area in the body consisting of more than one lung lobe. E.g. a lung cancer may have grown into multiple lobes of the lung. C100065 Andre Dekker Non-Thoracic Secondary Neoplasm A secondary neoplasm which is not found in the thorax. C100066 Andre Dekker Thoracic Secondary Neoplasm A secondary neoplasm which is found in the thorax. C100067 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Radiation Oncology Region of Interest The class of regions of interest used in Radiation Oncology and adhering to the Standardized Naming Conventions in Radiation Oncology. C100068 Andre Dekker Target Volume (ROI) A region of interest based on a delineation of a Target Volume. C100069 Andre Dekker Organ at Risk (ROI) A region of interest based on a delineation of an Organ-At-Risk (OAR). C100070 Andre Dekker Concurrent Chemoradiotherapy EuroCAT Umbrella Protocol for NSCLC Concomitant Chemoradiotheraoy Chemotherapy administered during radiotherapy. C100071 Andre Dekker Radiotherapy Margin A radiotherapy margin provides a buffer in the delineation of tissues to account for uncertainties. (ICRU 83) C100072 Andre Dekker Nonuniform Margin A radiotherapy margin which is not the same in all directions. C100073 Andre Dekker Uniform Margin A radiotherapy margin which is the same in all directions. C100074 Andre Dekker Tumor Length A one-dimensional size determination of the tumor along the length axis. Typically tumors in elongated organs (e.g. esophagus, rectum) are measured along the long axis of the organ rather than the traverse or other axes. C100075 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 AnalCanal (ROI) A region of interest based on a delineation of the anal canal as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100078 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Kidney_L (ROI) A region of interest based on a delineation of the left kidney as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100079 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Kidney_R (ROI) A region of interest based on a delineation of the right kidney as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100080 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 MainBronchus_L (ROI) A region of interest based on a delineation of the left main bronchus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100084 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Pulmonary (ROI) A region of interest based on a delineation of the pulmonary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100085 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Carotid (ROI) A region of interest based on a delineation of the common carotid artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100086 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Brachiocephali (ROI) A region of interest based on a delineation of the brachiocephalic artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100087 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Coronary (ROI) A region of interest based on a delineation of the coronary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100088 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Subclavicular (ROI) A region of interest based on a delineation of the subclavian artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100089 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_HypophysealSuperior (ROI) A region of interest based on a delineation of the superior hypophysial artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100090 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Aorta (ROI) A region of interest based on a delineation of the aorta as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100091 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 AnalSphincter (ROI) A region of interest based on a delineation of the anal sphincter as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100092 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Atrium (ROI) A region of interest based on a delineation of the cardiac atrium as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100093 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Bladder (ROI) A region of interest based on a delineation of the urinary bladder as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100094 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 BladderWall (ROI) A region of interest based on a delineation of the wall of urinary bladder as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100095 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 BrachialPlexus (ROI) A region of interest based on a delineation of the brachial nerve plexus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100096 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Brain (ROI) A region of interest based on a delineation of the brain as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100097 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 BrainStem (ROI) A region of interest based on a delineation of the brainstem as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100098 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Breast (ROI) A region of interest based on a delineation of the breast as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100099 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 BronchialTree (ROI) A region of interest based on a delineation of the bronchial tree as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100100 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 BaseOfTongue (ROI) A region of interest based on a delineation of the posterior part of tongue as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100101 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Carina (ROI) A region of interest based on a delineation of the carina of trachea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100102 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 CaudaEquina (ROI) A region of interest based on a delineation of the cauda equina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100103 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cerebellum (ROI) A region of interest based on a delineation of the cerebellum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100104 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cerebrum (ROI) A region of interest based on a delineation of the cerebral hemisphere as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100105 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Chiasm (ROI) A region of interest based on a delineation of the optic chiasm as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100106 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 CN_VII (ROI) A region of interest based on a delineation of the facial nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100107 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 CN_VIII (ROI) A region of interest based on a delineation of the vestibulocochlear nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100108 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cervix (ROI) A region of interest based on a delineation of the cervix of uterus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100109 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cochlea (ROI) A region of interest based on a delineation of the cochlea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100110 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Colon (ROI) A region of interest based on a delineation of the colon as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100111 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 ConstrMuscle (ROI) A region of interest based on a delineation of the constrictor muscle of pharynx as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100112 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cornea (ROI) A region of interest based on a delineation of the cornea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100113 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Duodenum (ROI) A region of interest based on a delineation of the duodenum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100114 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ear_Middle (ROI) A region of interest based on a delineation of the middle ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100115 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ear_External (ROI) A region of interest based on a delineation of the external ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100116 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Esophagus (ROI) A region of interest based on a delineation of the esophagus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100117 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Esophagus_Upper (ROI) A region of interest based on a delineation of the upper third of the esophagus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100118 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Esophagus_Lower (ROI) A region of interest based on a delineation of the lower third of the esophagus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100119 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Esophagus_Middle (ROI) A region of interest based on a delineation of the middle third of the esophagus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100120 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 External (ROI) A region of interest based on a delineation of the skin as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100121 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Eye (ROI) A region of interest based on a delineation of the eye as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100122 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Femur (ROI) A region of interest based on a delineation of the femur as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100123 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 FemoralJoint (ROI) A region of interest based on a delineation of the hip joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100124 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 FrontalLobe (ROI) A region of interest based on a delineation of the frontal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100125 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 GHJoint (ROI) A region of interest based on a delineation of the glenohumeral joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100126 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Globe (ROI) A region of interest based on a delineation of the eyeball as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100127 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Glottis (ROI) A region of interest based on a delineation of the glottis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100128 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 GreatVessel (ROI) A region of interest based on a delineation of the great blood vessel as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100129 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Heart (ROI) A region of interest based on a delineation of the heart as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100130 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Hippocampus (ROI) A region of interest based on a delineation of the hippocampus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100131 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Hypothalamus (ROI) A region of interest based on a delineation of the hypothalamus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100132 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Kidney (ROI) A region of interest based on a delineation of the kidney as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100133 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 LargeBowel (ROI) A region of interest based on a delineation of the large intestine as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100134 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Larynx (ROI) A region of interest based on a delineation of the larynx as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100135 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 LacrimalGland (ROI) A region of interest based on a delineation of the lacrimal gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100136 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Lens (ROI) A region of interest based on a delineation of the lens as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100137 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Lips (ROI) A region of interest based on a delineation of the lip as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100138 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Liver (ROI) A region of interest based on a delineation of the liver as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100139 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Lung (ROI) A region of interest based on a delineation of the lung as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100140 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Mandible (ROI) A region of interest based on a delineation of the mandible as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100141 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 MassMuscle (ROI) A region of interest based on a delineation of the masseter as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100142 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Mediastinum (ROI) A region of interest based on a delineation of the mediastinum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100143 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 MainBronchus (ROI) A region of interest based on a delineation of the main bronchus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100144 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 OccipitalLobe (ROI) A region of interest based on a delineation of the occipital lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100145 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 OpticNerve (ROI) A region of interest based on a delineation of the optic nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100146 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 OralCavity (ROI) A region of interest based on a delineation of the oral cavity proper as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100147 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ovary (ROI) A region of interest based on a delineation of the ovary as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100148 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Parametrium (ROI) A region of interest based on a delineation of the parametrium of body of uterus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100149 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 ParietalLobe (ROI) A region of interest based on a delineation of the parietal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100150 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Pancreas (ROI) A region of interest based on a delineation of the pancreas as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100151 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Parotid (ROI) A region of interest based on a delineation of the parotid gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100152 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 PelvicBones (ROI) A region of interest based on a delineation of the bony pelvis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100153 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 PenileBulb (ROI) A region of interest based on a delineation of the bulb of penis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100154 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Penis (ROI) A region of interest based on a delineation of the penis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100155 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Perineum (ROI) A region of interest based on a delineation of the perineum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100156 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Pericardium (ROI) A region of interest based on a delineation of the pericardium as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100157 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Pharynx (ROI) A region of interest based on a delineation of the pharynx as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100158 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 PharynxConst (ROI) A region of interest based on a delineation of the constrictor muscle of pharynx as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100159 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Pituitary (ROI) A region of interest based on a delineation of the pituitary gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100160 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Prostate (ROI) A region of interest based on a delineation of the prostate as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100161 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 PubicSymphysis (ROI) A region of interest based on a delineation of the pubic symphysis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100162 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rectum (ROI) A region of interest based on a delineation of the rectum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100163 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 RectalWall (ROI) A region of interest based on a delineation of the wall of rectum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100164 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Retina (ROI) A region of interest based on a delineation of the retina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100165 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib (ROI) A region of interest based on a delineation of the rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100166 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Sacrum (ROI) A region of interest based on a delineation of the sacrum as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100167 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 SalivaryGland (ROI) A region of interest based on a delineation of the salivary gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100168 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 SeminalVesicle (ROI) A region of interest based on a delineation of the seminal vesicle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100169 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 SmallBowel (ROI) A region of interest based on a delineation of the small intestine as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100170 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 SpinalCord (ROI) A region of interest based on a delineation of the spinal cord as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100171 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Spleen (ROI) A region of interest based on a delineation of the spleen as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100172 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Stomach (ROI) A region of interest based on a delineation of the stomach as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100173 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Submandibular (ROI) A region of interest based on a delineation of the submandibular gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100174 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Supertentorial (ROI) A region of interest based on a delineation of the supratentorial brain as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100175 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 TemporalLobe (ROI) A region of interest based on a delineation of the temporal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100176 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Testis (ROI) A region of interest based on a delineation of the testis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100177 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Thyroid (ROI) A region of interest based on a delineation of the thyroid gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100178 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 TMjoint (ROI) A region of interest based on a delineation of the temporomandibular joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100179 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Trachea (ROI) A region of interest based on a delineation of the trachea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100180 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Tongue (ROI) A region of interest based on a delineation of the tongue as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100181 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Urethra (ROI) A region of interest based on a delineation of the urethra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100182 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Uterus (ROI) A region of interest based on a delineation of the uterus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100183 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 V_Azygos (ROI) A region of interest based on a delineation of the azygos vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100184 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 V_CavaInferior (ROI) A region of interest based on a delineation of the inferior vena cava as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100185 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 V_CavaSuperior (ROI) A region of interest based on a delineation of the superior vena cava as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100186 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 V_Pulmonary (ROI) A region of interest based on a delineation of the pulmonary vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100187 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 V_SubClav (ROI) A region of interest based on a delineation of the subclavian vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100188 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Vagina (ROI) A region of interest based on a delineation of the vagina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100189 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_Cervical (ROI) A region of interest based on a delineation of the cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100190 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_Thoracic (ROI) A region of interest based on a delineation of the thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100191 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_Lumbar (ROI) A region of interest based on a delineation of the lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100192 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_Sacrum (ROI) A region of interest based on a delineation of the sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100193 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ventricle (ROI) A region of interest based on a delineation of the cardiac ventricle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100194 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Vessels (ROI) A region of interest based on a delineation of the blood vessel as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100195 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Vulva (ROI) A region of interest based on a delineation of the vulva as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100237 Andre Dekker Living with children EuroCAT Umbrella Protocol for NSCLC The social circumstance where a persons lives with one of more of their children. C100240 Andre Dekker Living with partner and children EuroCAT Umbrella Protocol for NSCLC The social circumstance where a persons lives with one of more of their children and a partner. C100245 Andre Dekker Positive Mediastinal Lymph Node Stations Number of positive lymph node stations (PLNS), assessed by FDG-PET scan, using the Naruke map using only mediastinal stations (excluding stations 10-14). C100246 Andre Dekker Quantity An abstract concept which is any specification of how many or how much of something there is. C100256 Andre Dekker Unimodality Therapy Use of one treatment modalities; e.g., surgery or radiation or chemotherapy. Can refer to use of two or more chemotherapeutic agents. Can refer to use of two or more radiotherapy modalities (e.g. a combination of brachytherapy and teletherapy). C100266 Andre Dekker Lymph Node by Zone and Station EuroCAT Umbrella Protocol for NSCLC Lymph nodes classified in zones and stations according to lymph node map of the AJCC 7th edition of the TNM classification for lung cancer. For prognostic purposes, thoracic lymph nodes can be divided into prognostic zones which is easier to remember than individual thoracic lymph node stations/levels. For more information see http://dx.doi.org/10.1097/JTO.0b013e3181a0d82e C100270 Andre Dekker CTCAE version Version of the Common Terminology Criteria for Adverse Events (CTCAE) system published by the US National Cancer Institute (NCI). C100272 Andre Dekker CTCAE v4.0 EuroCAT Umbrella Protocol for NSCLC Fourth version (published 2009-2010) of the Common Terminology Criteria for Adverse Events (CTCAE) system published by the US National Cancer Institute (NCI). C100279 Andre Dekker CTCAE v3.0 Third version (published 2003-2006) of the Common Terminology Criteria for Adverse Events (CTCAE) system published by the US National Cancer Institute (NCI). C100289 Andre Dekker CTCAE v2.0 Second version (published 1998-1999) of the Common Terminology Criteria for Adverse Events (CTCAE) system published by the US National Cancer Institute (NCI). C100290 Andre Dekker Supraclavicular zone The supraclavicular zone consists of lymph nodes of nodal station 1. C100294 Andre Dekker Aortic Nodes Artic nodes are lymph nodes in the subaortic or para-aortic zones (nodal stations 5-6). C100316 Andre Dekker AP zone The aortopulmonary zone consists of lymph nodes of nodal stations 5-6. C100319 Andre Dekker Patient GUID Patient UUID A globally unique identifier identifying a patient. C100320 Andre Dekker Superior Mediastinal Nodes Supoerior mediastinal nodes are lymph nodes in the upper zone (nodal stations 2-4). C100321 Andre Dekker DICOM Functional Concept A concept which is of interest because it pertains to the DICOM protocol. Examples are target and other Information Object Defintion and Entities. C100322 Andre Dekker Upper zone The upper zone consists of lymph nodes of nodal stations 2-4. C100323 Andre Dekker D95 Minimum dose to at least 95% of the volume of a target volume or organ at risk. D95 is often reported for target volumes. C100324 Andre Dekker D98 Dnear-min Minimum dose to at least 98% of the volume of a target volume or organ at risk. D98 is often called the near minimum dose. C100325 Andre Dekker D50 Dmedian Median Radiation Dose Minimum dose to at least 50% of the volume of a target volume or organ at risk. Equivalent to the median dose. C100326 Andre Dekker D2 Dnear-max Minimum dose to at least 2% of the volume of a target volume or organ at risk. D98 is often called the near maximum dose. C100328 Johan van Soest Local control time Elapsed time that a person has been living with/without a related observation/procedure/event/finding of local control/recurrence. C100329 Andre Dekker Inferior Mediastinal Nodes Inferior mediastinal nodes are lymph nodes in the subcarinal or lower zones (nodal stations 7-9). C100330 Johan van Soest Distant control time Elapsed time that a person has been living with/without a related observation/procedure/event/finding of distant control/recurrence. C100333 Andre Dekker Subcarinal zone The subcarinal zone consists of lymph nodes of nodal station 7. C100334 Andre Dekker Lower zone The lower zone consists of lymph nodes of nodal stations 8-9. C100335 Andre Dekker N1 nodes N1 nodes are lymph nodes in the hilar/interlobar or peripheral zones (nodal stations 10-14). C100336 Andre Dekker Hilar/interlobar zone The hilar/interlobar zone consists of lymph nodes of nodal stations 10-11. C100339 Andre Dekker Peripheral zone The peripheral zone consists of lymph nodes of nodal stations 12-14. C100344 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Lung_L (ROI) A region of interest based on a delineation of the left lung as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100345 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Lung_R (ROI) A region of interest based on a delineation of the right lung as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100346 Andre Dekker GTVp (ROI) A region of interest based on a delineation of the Gross Tumor Volume of a primary tumor. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100347 Andre Dekker GTVn (ROI) A region of interest based on a delineation of the Gross Tumor Volume of a metastatic regional node. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100348 Andre Dekker Overall Treatment Time - Radiotherapy EuroCAT Umbrella Protocol for NSCLC OTT Overall treatment time calculated from first until the last day of radiotherapy C100349 Andre Dekker Radiation Therapy Alone A treatment where only radiation is given. This is in contract to e.g. chemoradiotherapy or a combination of surgery and radiation. Can refer to use of two or more radiotherapy modalities (e.g. a combination of brachytherapy and teletherapy). C100350 Andre Dekker Parallel-Opposed Fields Radiation Therapy Parallel opposed fields radiotherapy is a simple form of radiotherapy when using multiple fields. By aiming the two beams along the same axis, the dose fall off in one will be compensated for by the increased dose in the other. C100351 Andre Dekker 2-Dimensional Radiation Therapy Two-dimensional (2-D) radiotherapy is a simple form of radiotherapy where treatment planning is based on standardized treatment techniques applied to classes of patients thought to be similar. The process makes use of an X-ray simulator and a 2-D computer treatment planning system used for calculation of dose distributions. C100352 Andre Dekker Radiotherapy Total Treatment Dose EuroCAT Umbrella Protocol for NSCLC TTD The total absorbed radiation dose prescribed or delivered to a tumor in a complete radiotherapy treatment. C100353 Andre Dekker Radiotherapy Fraction Dose EuroCAT Umbrella Protocol for NSCLC Radiation dose delivered per fraction C100354 Andre Dekker Number of Radiotherapy Fractions The count of radiotherapy fractions given in a certain time interval (e.g. per day) or in a certain coherent context (e.g. per treatment). C100355 Andre Dekker Number of Radiotherapy Fractions Per Day EuroCAT Umbrella Protocol for NSCLC The count of radiotherapy fractions given per day. C100356 Andre Dekker Number of Radiotherapy Fractions Per Treatment EuroCAT Umbrella Protocol for NSCLC The count of radiotherapy fractions given in a radiotherapy treatment as a whole. C100357 Andre Dekker Dose Volume Histogram - Dx Minimum radiation dose to at least x% of the volume. C100358 Andre Dekker Dose Volume Histogram - Vx The percentage volume receiving at least x Gy C100359 Andre Dekker V20 of Lung The percentage of the lung volume (with subtraction of the volume involved by lung cancer) which receives radiation doses of 20 Gy or more. C100360 Andre Dekker Radiation Dose From Dose Volume Histogram A radiation dose quantity derived from a Dose Volume Histogram. C100361 Andre Dekker Dmean Mean Radiation Dose The mean radiation dose in a given region of interest. C100362 Andre Dekker Mean Lung Dose EuroCAT Umbrella Protocol for NSCLC MLD The mean radiation dose to the lung as an organ at risk (with subtraction of the volume involved by lung cancer). C100363 Andre Dekker Mean Esophagus Dose EuroCAT Umbrella Protocol for NSCLC The mean radiation dose to the esophagus as an organ at risk. C100365 Andre Dekker Maximum Esophagus Dose EuroCAT Umbrella Protocol for NSCLC The maximum radiation dose to the esophagus as an organ at risk. C100366 Andre Dekker D0 Dmax Maximum Radiation Dose The mininum radiation dose given to at least 0% of the volume (i.e. to a single point ) of the target volume or organ at risk. Equivalent to the maximum radiation dose. C100367 Andre Dekker FEV1 with Medication EuroCAT Umbrella Protocol for NSCLC The FEV1 measured during bronchodilation and/or steroid use. C100368 Andre Dekker http://purl.bioontology.org/ontology/NCIT Percent Predicted Diffusion Capacity of the Lung for Carbon Monoxide EuroCAT Umbrella Protocol for NSCLC The degree to which inhaled carbon monoxide diffuses from the alveoli into the blood, expressed as a proportion of the predicted normal value. C100369 Andre Dekker Acute Radiation Therapy Adverse Event Early Radiation Therapy Adverse Event Toxicity from radiation therapy. The critera are relevant from day 1, the commencement of therapy, through day 90. (RTOG definition) C100370 Andre Dekker Adverse Event by Time of Onset Adverse event categorized by the time of onset. Typically adverse events are considered either acute/early or late relative to an intervention. C100371 Andre Dekker Late Radiation Therapy Adverse Event All effects seen after 90 days from the beginning of radiation therapy. C100372 Andre Dekker Definitely Related to Cancer EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as certainly related to cancer. C100373 Andre Dekker Unrelated to Cancer EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as clearly not related to cancer. C100374 Andre Dekker Unlikely Related to Cancer EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as unlikely related to cancer. C100375 Andre Dekker Possibly Related to Cancer EuroCAT Umbrella Protocol for NSCLC A characteristic indicating that an adverse event may be related to cancer. C100376 Andre Dekker Probably Related to Cancer EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as likely related to cancer. C100377 Andre Dekker Probably Related to Pre-existing Comorbidity EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as likely related to pre-existing comorbidity. C100378 Andre Dekker Possibly Related to Pre-existing Comorbidity EuroCAT Umbrella Protocol for NSCLC A characteristic indicating that an adverse event may be related to pre-existing comorbidity. C100379 Andre Dekker Definitely Related to Pre-existing Comorbidity EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as certainly related to pre-existing comorbidity. C100380 Andre Dekker Conditionally Related to Pre-existing Comorbidity EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as unclassified in term of its relation to pre-existing comorbidity. C100381 Andre Dekker Conditionally Related to Cancer EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as unclassified in term of its relation to cancer. C100382 Andre Dekker Unrelated to Pre-existing Comorbidity EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as clearly not related to pre-existing comorbidity. C100383 Andre Dekker Unlikely Related to Pre-existing Comorbidity EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as unlikely related to pre-existing comorbidity. C100384 Andre Dekker Relation to Cancer Unclassifiable EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as unclassifiable in term of its relation to cancer. C100385 Andre Dekker Relation to Pre-existing Comorbidity Unclassifiable EuroCAT Umbrella Protocol for NSCLC A characteristic used to qualify the adverse event as unclassifiable in term of its relation to pre-existing comorbidity. C100386 Andre Dekker ECOG Performance Status≥2 EuroCAT Umbrella Protocol for NSCLC A performance status which is ECOG 2 or worse. C100387 Andre Dekker Never or Former Smoker A person who was not smoking at the time of consideration and may or may not have smoked in the past. C100388 Andre Dekker Both Lobes of the Left Lung An area in the body consisting of both left lung lobes. E.g. a lung cancer may have grown into both lobes of the left lung. 5 C100390 Andre Dekker Minimum of 5 Positive Lymph Node Stations A count of at least 5 positive lymph node stations assessed by FDG-PET scan. C100393 Andre Dekker T0 or T1 Stage Finding A primary tumor TNM finding indicating that there is either no evidence of primary tumor (T0) or that the cancer is limited to the site of growth (T1). C100453 Andre Dekker Medical Contraindication to Concurrent Chemoradiotherapy A symptom or medical condition that makes a concurrent chemoradiotherapy inadvisable because a person is likely to have a bad reaction. C100454 Andre Dekker Equivalent 2Gy Dose EQD2 Equivalent 2Gy dose: EQD2 = n * d * (d + α/β) / (2 + α/β) 5 C100455 Andre Dekker Minimum of 5 Positive Mediastinal Lymph Node Stations A count of at least 5 positive lymph node stations assessed by FDG-PET scan using only mediastinal stations (excluding stations 10-14). C100456 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 MainBronchus_R (ROI) A region of interest based on a delineation of the right main bronchus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100457 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Pulmonary_L (ROI) A region of interest based on a delineation of the left pulmonary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100458 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Pulmonary_R (ROI) A region of interest based on a delineation of the right pulmonary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100459 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Carotid_R (ROI) A region of interest based on a delineation of the right common carotid artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100460 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Carotid_L (ROI) A region of interest based on a delineation of the left common carotid artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100461 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Coronary_L (ROI) A region of interest based on a delineation of the left coronary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100462 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Coronary_R (ROI) A region of interest based on a delineation of the right coronary artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100463 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_HypophysealInferior (ROI) A region of interest based on a delineation of the inferior hypophysial artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100464 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Subclavicular_L (ROI) A region of interest based on a delineation of the left subclavian artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100465 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_Subclavicular_R (ROI) A region of interest based on a delineation of the right subclavian artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100466 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_HypophysealInferior_L (ROI) A region of interest based on a delineation of the left inferior hypophyseal artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100467 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_HypophysealInferior_R (ROI) A region of interest based on a delineation of the right inferior hypophyseal artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100468 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_HypophysealSuperior_L (ROI) A region of interest based on a delineation of the left superior hypophyseal artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100469 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 A_HypophysealSuperior_R (ROI) A region of interest based on a delineation of the right superior hypophyseal artery as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100470 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Atrium_L (ROI) A region of interest based on a delineation of the left atrium as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100471 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Atrium_R (ROI) A region of interest based on a delineation of the right atrium as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100472 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 BrachialPlexus_L (ROI) A region of interest based on a delineation of the left brachial nerve plexus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100473 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 BrachialPlexus_R (ROI) A region of interest based on a delineation of the right brachial nerve plexus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100474 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Breast_L (ROI) A region of interest based on a delineation of the left breast as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100475 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Breast_R (ROI) A region of interest based on a delineation of the right breast as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100476 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 BronchialTree_L (ROI) A region of interest based on a delineation of the left bronchial tree as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100477 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 BronchialTree_R (ROI) A region of interest based on a delineation of the right bronchial tree as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100478 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cerebrum_L (ROI) A region of interest based on a delineation of the left cerebral hemisphere as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100479 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cerebrum_R (ROI) A region of interest based on a delineation of the right cerebral hemisphere as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100480 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 CN_VII_L (ROI) A region of interest based on a delineation of the left facial nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100481 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 CN_VII_R (ROI) A region of interest based on a delineation of the right facial nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100482 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 CN_VIII_L (ROI) A region of interest based on a delineation of the left vestibulocochlear nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100483 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 CN_VIII_R (ROI) A region of interest based on a delineation of the right vestibulocochlear nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100484 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cochlea_L (ROI) A region of interest based on a delineation of the left cochlea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100485 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cochlea_R (ROI) A region of interest based on a delineation of the right cochlea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100486 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cornea_L (ROI) A region of interest based on a delineation of the left cornea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100487 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Cornea_R (ROI) A region of interest based on a delineation of the right cornea as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100488 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ear_External_L (ROI) A region of interest based on a delineation of the left external ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100489 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ear_External_R (ROI) A region of interest based on a delineation of the right external ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100490 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ear_Middle_L (ROI) A region of interest based on a delineation of the left middle ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100491 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ear_Middle_R (ROI) A region of interest based on a delineation of the right middle ear as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100492 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Eye_L (ROI) A region of interest based on a delineation of the left eye as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100493 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Eye_R (ROI) A region of interest based on a delineation of the right eye as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100494 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 FemoralJoint_L (ROI) A region of interest based on a delineation of the left hip joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100495 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 FemoralJoint_R (ROI) A region of interest based on a delineation of the right hip joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100496 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Femur_L (ROI) A region of interest based on a delineation of the left femur as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100497 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Femur_R (ROI) A region of interest based on a delineation of the right femur as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100498 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 FrontalLobe_L (ROI) A region of interest based on a delineation of the left frontal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100499 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 FrontalLobe_R (ROI) A region of interest based on a delineation of the right frontal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100500 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 GHJoint_L (ROI) A region of interest based on a delineation of the left glenohumeral joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100501 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 GHJoint_R (ROI) A region of interest based on a delineation of the right glenohumeral joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100502 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Globe_L (ROI) A region of interest based on a delineation of the left eyeball as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100503 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Globe_R (ROI) A region of interest based on a delineation of the right eyeball as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100504 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Hippocampus_L (ROI) A region of interest based on a delineation of the left hippocampus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100505 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Hippocampus_R (ROI) A region of interest based on a delineation of the right hippocampus as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100506 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 MassMuscle_L (ROI) A region of interest based on a delineation of the left masseter as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100507 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 MassMuscle_R (ROI) A region of interest based on a delineation of the right masseter as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100508 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 OccipitalLobe_L (ROI) A region of interest based on a delineation of the left occipital lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100509 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 OccipitalLobe_R (ROI) A region of interest based on a delineation of the right occipital lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100510 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 OpticNerve_L (ROI) A region of interest based on a delineation of the left optic nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100511 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 OpticNerve_R (ROI) A region of interest based on a delineation of the right optic nerve as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100512 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ovary_L (ROI) A region of interest based on a delineation of the left ovary as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100513 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ovary_R (ROI) A region of interest based on a delineation of the right ovary as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100514 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 ParietalLobe_L (ROI) A region of interest based on a delineation of the left parietal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100515 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 ParietalLobe_R (ROI) A region of interest based on a delineation of the right parietal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100516 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Parotid_L (ROI) A region of interest based on a delineation of the left parotid gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100517 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Parotid_R (ROI) A region of interest based on a delineation of the right parotid gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100519 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Retina_L (ROI) A region of interest based on a delineation of the left retina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100520 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Retina_R (ROI) A region of interest based on a delineation of the left retina as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100521 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib1_L (ROI) A region of interest based on a delineation of the left first rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100522 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib2_L (ROI) A region of interest based on a delineation of the left second rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100523 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib3_L (ROI) A region of interest based on a delineation of the left third rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100524 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib4_L (ROI) A region of interest based on a delineation of the left fourth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100525 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib5_L (ROI) A region of interest based on a delineation of the left fifth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100526 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib6_L (ROI) A region of interest based on a delineation of the left sixth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100527 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib7_L (ROI) A region of interest based on a delineation of the left seventh rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100528 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib8_L (ROI) A region of interest based on a delineation of the left eighth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100529 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib9_L (ROI) A region of interest based on a delineation of the left ninth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100530 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib10_L (ROI) A region of interest based on a delineation of the left tenth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100531 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib11_L (ROI) A region of interest based on a delineation of the left eleventh rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100532 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib12_L (ROI) A region of interest based on a delineation of the left twelfth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100533 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib12_R (ROI) A region of interest based on a delineation of the right twelfth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100534 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib11_R (ROI) A region of interest based on a delineation of the right eleventh rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100535 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib10_R (ROI) A region of interest based on a delineation of the right tenth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100536 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib9_R (ROI) A region of interest based on a delineation of the right ninth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100537 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib8_R (ROI) A region of interest based on a delineation of the right eighth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100538 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib7_R (ROI) A region of interest based on a delineation of the right seventh rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100539 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib6_R (ROI) A region of interest based on a delineation of the right sixth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100540 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib5_R (ROI) A region of interest based on a delineation of the right fifth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100541 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib4_R (ROI) A region of interest based on a delineation of the right fourth rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100542 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib3_R (ROI) A region of interest based on a delineation of the right third rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100543 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib2_R (ROI) A region of interest based on a delineation of the right second rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100544 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Rib1_R (ROI) A region of interest based on a delineation of the right first rib as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100545 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 SeminalVesicle_L (ROI) A region of interest based on a delineation of the left seminal vesicle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100546 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 SeminalVesicle_R (ROI) A region of interest based on a delineation of the right seminal vesicle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100547 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Submandibular_L (ROI) A region of interest based on a delineation of the left submandibular gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100548 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Submandibular_R (ROI) A region of interest based on a delineation of the right submandibular gland as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100549 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 TemporalLobe_L (ROI) A region of interest based on a delineation of the left temporal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100550 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 TemporalLobe_R (ROI) A region of interest based on a delineation of the right temporal lobe as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100551 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Testis_L (ROI) A region of interest based on a delineation of the left testis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100552 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Testis_R (ROI) A region of interest based on a delineation of the right testis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100553 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 TMjoint_L (ROI) A region of interest based on a delineation of the left temporomandibular joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100554 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 TMjoint_R (ROI) A region of interest based on a delineation of the right temporomandibular joint as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100555 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 V_SubClav_L (ROI) A region of interest based on a delineation of the left subclavian vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100556 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 V_SubClav_R (ROI) A region of interest based on a delineation of the right subclavian vein as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100558 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_C1 (ROI) A region of interest based on a delineation of the atlas as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100559 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_C2 (ROI) A region of interest based on a delineation of the axis as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100560 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_C3 (ROI) A region of interest based on a delineation of the third cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100561 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_C4 (ROI) A region of interest based on a delineation of the fourth cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100562 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_C5 (ROI) A region of interest based on a delineation of the fifth cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100563 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_C6 (ROI) A region of interest based on a delineation of the sixth cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100564 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_C7 (ROI) A region of interest based on a delineation of the seventh cervical vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100565 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_L1 (ROI) A region of interest based on a delineation of the first lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100566 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_L2 (ROI) A region of interest based on a delineation of the second lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100567 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_L3 (ROI) A region of interest based on a delineation of the third lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100568 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_L4 (ROI) A region of interest based on a delineation of the fourth lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100569 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_L5 (ROI) A region of interest based on a delineation of the fifth lumbar vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100570 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_S1 (ROI) A region of interest based on a delineation of the first sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100571 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_S2 (ROI) A region of interest based on a delineation of the second sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100572 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_S3 (ROI) A region of interest based on a delineation of the third sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100573 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_S4 (ROI) A region of interest based on a delineation of the fourth sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100574 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_S5 (ROI) A region of interest based on a delineation of the fifth sacral vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100575 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T1 (ROI) A region of interest based on a delineation of the first thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100576 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T2 (ROI) A region of interest based on a delineation of the second thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100577 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T3 (ROI) A region of interest based on a delineation of the third thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100578 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T4 (ROI) A region of interest based on a delineation of the fourth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100579 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T5 (ROI) A region of interest based on a delineation of the fifth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100580 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T6 (ROI) A region of interest based on a delineation of the sixth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100581 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T7 (ROI) A region of interest based on a delineation of the seventh thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100582 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T8 (ROI) A region of interest based on a delineation of the eighth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100583 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T9 (ROI) A region of interest based on a delineation of the ninth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100584 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T10 (ROI) A region of interest based on a delineation of the tenth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100585 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T11 (ROI) A region of interest based on a delineation of the eleventh thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100586 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 VB_T12 (ROI) A region of interest based on a delineation of the twelfth thoracic vertebra as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100587 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ventricle_L (ROI) A region of interest based on a delineation of the left ventricle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100588 Andre Dekker http://dx.doi.org/10.1016/j.ijrobp.2011.09.054 Ventricle_R (ROI) A region of interest based on a delineation of the right ventricle as an organ at risk in radiation oncology. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100589 Andre Dekker Gross Tumor Volume - Metastasis The gross tumor volume of a distant metastasis of a tumor. C100590 Andre Dekker CTV (ROI) A region of interest based on a delineation of the Clinical Target Volume. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100591 Andre Dekker Clinical Target Volume - Node CTVn The clinical target volume of a metastatic regional node of a tumor. C100594 Andre Dekker Clinical Target Volume - Primary Tumor The clinical target volume of a primary tumor. C100595 Andre Dekker ITV (ROI) A region of interest based on a delineation of the Internal Target Volume. C100596 Andre Dekker PRV (ROI) A region of interest based on a delineation of a Planning Organ at Risk Volume (PRV). The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100597 Andre Dekker Radiation Oncology Functional Concept A concept which is of interest because it pertains to the carrying out of radiation oncology. Examples are target and other irradiated volumes, margins etc. C100598 Andre Dekker Gross Tumor Volume GTV The Gross Tumor Volume (GTV) is the gross demonstrable extent and location of the tumor. The GTV may consist of a primary tumor (primary tumor GTV or GTV-T), metastatic regional node(s) (nodal GTV or GTV-N), or distant metastasis (metastatic GTV, or GTV-M). Typically, different GTVs are defined for the primary tumor and the regional node(s). But in some particular clinical situations, it might well be that the metastatic node cannot be distinguished from the primary tumor, e.g., a nasopharyngeal undifferentiated carcinoma infiltrating posterolaterally into the retropharyngeal space, including possible infiltrated nodes. In such situations, a single GTV encompassing both the primary tumor and the node(s) may be delineated. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001 C100599 Andre Dekker Internal Target Volume ITV In ICRU Report 62 (ICRU, 1999), the Internal Target Volume (ITV) was defined as the CTV plus a margin taking into account uncertainties in size, shape, and position of the CTV within the patient. Such a margin was called the internal margin as opposed to the set-up margin. In ICRU Report 62, it was recommended that internal and external margins be added quadratically, but often in practice they are instead added linearly, which can lead to an unacceptably large margin. The ITV might be useful only in clinical situations in which uncertainty concerning the CTV location dominates setup uncertainties and/or when they are independent. The ITV is considered an optional tool in helping to delineate the PTV. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001 C100600 Andre Dekker Planning Target Volume PTV The Planning Target Volume (PTV) is a geometrical concept introduced for treatment planning and evaluation. It is the recommended tool to shape absorbed-dose distributions to ensure that the prescribed absorbed dose will actually be delivered to all parts of the CTV with a clinically acceptable probability, despite geometrical uncertainties such as organ motion and setup variations. It is also used for absorbed-dose prescription and reporting. It surrounds the representation of the CTV with a margin such that the planned absorbed dose is delivered to the CTV. This margin takes into account both the internal and the setup uncertainties. The setup margin accounts specifically for uncertainties in patient positioning and alignment of the therapeutic beams during the treatment planning, and through all treatment sessions. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001 C100601 Andre Dekker Clinical Target Volume CTV The Clinical Target Volume (CTV) is a volume of tissue that contains a demonstrable GTV and/or subclinical malignant disease with a certain probability of occurrence considered relevant for therapy. There is no general consensus on what probability is considered relevant for therapy, but typically a probability of occult disease higher than from 5 % to 10 % is assumed to require treatment. This remains a clinical judgment in which the type of malignancy, the consequence of failure, and the expected feasibility of salvage treatment need to be considered. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001 C100602 Andre Dekker CTVn (ROI) A region of interest based on a delineation of the Clinical Target Volume of a metastatic regional node. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100603 Andre Dekker Clinical Target Volume - Metastasis The clinical target volume of a distant metasasis of a tumor. C100604 Andre Dekker CTVp (ROI) A region of interest based on a delineation of the Clinical Target Volume of a primary tumor. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100605 Andre Dekker Gross Tumor Volume - Node EuroCAT Umbrella Protocol for NSCLC The gross tumor volume of a metastatic regional node of a tumor. C100606 Andre Dekker Gross Tumor Volume - Primary Tumor EuroCAT Umbrella Protocol for NSCLC The gross tumor volume of a primary tumor. C100607 Andre Dekker Target Volume A Target Volume is a volume of tissue or of a geometrical concept forming the target for irradiation during radiation oncology. C100608 Andre Dekker Planning Organ at Risk Volume The Planning Organ at Risk Volume (PRV) is a geometrical concept introduced for treatment planning and evaluation. It surrounds the representation of the Organ at Risk (OAR) with a margin. This margin takes into account both the internal and the setup uncertainties. The setup margin accounts specifically for uncertainties in patient positioning and alignment of the therapeutic beams during the treatment planning, and through all treatment sessions. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001 C100609 Andre Dekker Organ at Risk The Organ-At-Risk (OAR) or critical normal structures are tissues that if irradiated could suffer significant morbidity and thus might influence the treatment planning and/or the absorbed-dose prescription. (ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001 C100610 Andre Dekker PTVn (ROI) A region of interest based on a delineation of the Planning Target Volume of a metastatic regional node. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100611 Andre Dekker PTVp (ROI) A region of interest based on a delineation of the Planning Target Volume of a primary tumor. The label adheres to the standardized naming convention proposed by Santanam et al (http://dx.doi.org/10.1016/j.ijrobp.2011.09.054). C100612 Andre Dekker Planning Target Volume - Metastasis The Planning Target Volume of a distant metasasis of a tumor. C100613 Andre Dekker Planning Target Volume - Node The Planning Target Volume of a metastatic regional node of a tumor. C100614 Andre Dekker Planning Target Volume - Primary Tumor The Planning Target Volume of a primary tumor. C100615 Andre Dekker Treated Volume The TV is the volume of tissue enclosed within a specific isodose envelope, with the absorbed dose specified by the radiation oncology team as appropriate to achieve tumor eradication or palliation, within the bounds of acceptable complications. As proposed in proton therapy (ICRU, 2007), D98% could be selected to determine the TV in photon therapy. When reported, the value of the isodose selected to define the TV should be quoted either relative to the prescribed absorbed dose or in absolute terms. It is important to identify the shape, size, and position of the TV in relation to the PTV for several reasons. One reason is to provide information to evaluate causes for local recurrences (inside or outside the TV).(ICRU 83) For more information: http://dx.doi.org/10.1093/jicru/ndq001 C100616 Andre Dekker Metabolic Tumor Volume Metabolic tumor volume (MTV) is the volume of tumor tissues with increased FDG uptake measured by an 18F-FDG PET scan. C100620 Andre Dekker FUMIR Regimen Regimen combining Mitomycin and Fluorouracil (with concurrent radiation) C100622 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/9112145 Tumor Regression Grade - Dworak Tumor regression grade according to the Dworak system. C100623 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/8194005 Tumor Regression Grade - Mandard Tumor regression grade according to the Mandard system. C100624 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/8194005 TRG1 - Mandard C100625 Andre Dekker Complete Regression C100626 Andre Dekker Near Complete Regression C100627 Andre Dekker Moderate Regression C100628 Andre Dekker Minimal Regression C100629 Andre Dekker No Regression C100630 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/8194005 TRG2 - Mandard C100631 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/8194005 TRG3 - Mandard C100632 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/8194005 TRG4 - Mandard C100633 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/8194005 TRG5 - Mandard C100634 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/9112145 TRG0 - Dworak C100635 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/9112145 TRG1 - Dworak C100636 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/9112145 TRG2 - Dworak C100637 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/9112145 TRG3 - Dworak C100638 Andre Dekker https://www.ncbi.nlm.nih.gov/pubmed/9112145 TRG4 - Dworak C100639 Andre Dekker Motion Management Procedure A procedure in which internal motion is managed of organs and/or regions of interest (e.g. tumors) during radiotherapy or imaging or another therapeutic or imaging procedure. This management can be implicit in the procedure (e.g. 4D-CT) are added to any procedure (e.g. breath hold). The motion can be due to respiration, circulation, peristalsis, swallowing, etc. Both procedures to prevent motion (e.g. breath hold) and/or deal with motion (e.g. gating) are part of this class of concepts. Not meant here are procedures meant to deal with the overal motion of the patient (e.g immobilisation). C100644 Andre Dekker Deep Inspiration Breath-Hold DIBH Deep Inspiration Breath-Hold is mostly used in radiotherapy and involves the patient inspiring to a specified threshold and then holding that level of inspiration during the delivery of radiation. C100645 Andre Dekker Breathing Modification Procedure A class of procedures where respiratory motion is managed by patients temporarily changing the way they breath, either forced or voluntary and for either therapeutic or diagnostic procedures. C100646 Andre Dekker Abdominal Compression A procedure which compresses the abdomen and thereby forcing the patient to use shallow breathing. This in turn reduces the motion associated with respiration. C100647 Andre Dekker Respiratory Gated Radiation Therapy In respiratory gated radiation therapy the beam is switched on when the tumor is in the right phase of the respiration. C100648 Andre Dekker Tumor Tracking Radiation Therapy In tumor tracking radiation therapy the beam is always on and follows the tumor during respiration. It often involves implanting fiducial markers into the tumor. C100660 Andre Dekker Partial Mesorectal Excision PME Surgical procedure for rectosigmoid and upper rectal cancers where the rectum is transected 5 cm below the tumor. C100684 Andre Dekker Unilateral Lymph Node Dissection Lymph node dissection on only one side of regional lymph nodes. This is usually done when the tumor is located on that side of the body. C100685 Andre Dekker Bilateral Lymph Node Dissection Lymph node dissection on both sides of regional lymph nodes. This is usually done when the tumor is centrally located . C100701 Andre Dekker Extra mesorectal lymph node group Lymph nodes outside the mesorectum. radlex:RID165 http://purl.bioontology.org/ontology/RADLEX Anal sphincter Either of two sphincters controlling the closing of the anus: a : an outer sphincter of striated muscle extending from the coccyx to the central tendinous part of the perineum and surrounding the anus immediately beneath the skin—called also external anal sphincter, sphincter ani externus b : an inner sphincter formed by thickening of the circular smooth muscle of the rectum—called also internal anal sphincter, sphincter ani internus pecify internal or external. owl:Thing