Tariq Abdulla An ontology that describes physiological processes and functions in the skin, across a wide range of spatial scale. Skin Physiology Ontology SPSO_000020 bearer_of SPSO_000021 function_of SPSO_000024 generically_inheres_in SPSO_000025 has_quality SPSO_000027 has_role SPSO_000019 inheres_in SPSO_000022 quality_of SPSO_000023 role_of http://purl.org/obo/owl/ro#genid8 relationship ro_bfo_bridge Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant http://purl.org/obo/owl/ro#genid14 relationship Parthood as a relation between instances: The primitive instance-level relation p part_of p1 is illustrated in assertions such as: this instance of rhodopsin mediated phototransduction part_of this instance of visual perception. This relation satisfies at least the following standard axioms of mereology: reflexivity (for all p, p part_of p); anti-symmetry (for all p, p1, if p part_of p1 and p1 part_of p then p and p1 are identical); and transitivity (for all p, p1, p2, if p part_of p1 and p1 part_of p2, then p part_of p2). Analogous axioms hold also for parthood as a relation between spatial regions. For parthood as a relation between continuants, these axioms need to be modified to take account of the incorporation of a temporal argument. Thus for example the axiom of transitivity for continuants will assert that if c part_of c1 at t and c1 part_of c2 at t, then also c part_of c2 at t. Parthood as a relation between classes: To define part_of as a relation between classes we again need to distinguish the two cases of continuants and processes, even though the explicit reference to instants of time now falls away. For continuants, we have C part_of C1 if and only if any instance of C at any time is an instance-level part of some instance of C1 at that time, as for example in: cell nucleus part_ of cell. part_of http://purl.org/obo/owl/ro#genid18 relationship ro_bfo_bridge An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. preceded_by http://purl.org/obo/owl/ro#genid5 relationship relationship Relation between Amount of matter and physical object in the cognitivist / multiplicative formulation of an ontology. Constitutes SPSO_000000 SPSO_000004 has_determinate_part The parts including ingredients, constituent parts and determinatge parts, but not granular parts. SPSO_000001 has_gross_part SPSO_000005 has_ingredient SPSO_000006 is_constituted_by Countable discrete parts such that the whole is diminished by the loss of one of them. See (Rector, Rogers and Bittner 2006) SPSO_000002 is_determinate_part_of The parts including ingredients, constituent parts and determinatge parts, but not granular parts. SPSO_000000 is_gross_part_of SPSO_000003 is_ingredient_of bfo:Entity entity snap:Continuant Definition: An entity [bfo:Entity] that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. Examples: a heart, a person, the color of a tomato, the mass of a cloud, a symphony orchestra, the disposition of blood to coagulate, the lawn and atmosphere in front of our building Synonyms: endurant continuant snap:DependentContinuant Definition: A continuant [snap:Continuant] that is either dependent on one or other independent continuant [snap:IndependentContinuant] bearers or inheres in or is borne by other entities. dependent_continuant snap:IndependentContinuant Definition: A continuant [snap:Continuant] that is a bearer of quality [snap:Quality] and realizable entity [snap:RealizableEntity] entities, in which other entities inhere and which itself cannot inhere in anything. Examples: an organism, a heart, a leg, a person, a symphony orchestra, a chair, the bottom right portion of a human torso, the lawn and atmosphere in front of our building Synonyms: substantial entity independent_continuant span:Occurrent Definition: An entity [bfo:Entity] that has temporal parts and that happens, unfolds or develops through time. Sometimes also called perdurants. Examples: the life of an organism, a surgical operation as processual context for a nosocomical infection, the spatiotemporal context occupied by a process of cellular meiosis, the most interesting part of Van Gogh's life, the spatiotemporal region occupied by the development of a cancer tumor Synonyms: perdurant occurrent MultiscaleSkinPhysiologyOntology:AcellularAnatomicalStructure AcellularAnatomicalStructure SPSO_000000 MultiscaleSkinPhysiologyOntology:AcellularMembrane AcellularMembrane SPSO_000001 MultiscaleSkinPhysiologyOntology:Adipocyte Adipocyte SPSO_000136 MultiscaleSkinPhysiologyOntology:AdiposeTissue AdiposeTissue SPSO_000024 MultiscaleSkinPhysiologyOntology:Anagen Anagen SPSO_000061 MultiscaleSkinPhysiologyOntology:Anaphase Anaphase SPSO_000001 MultiscaleSkinPhysiologyOntology:AnatomicalStructure AnatomicalStructure SPSO_000073 FMA: 67135 MultiscaleSkinPhysiologyOntology:Antibody Antibody SPSO_000120 MultiscaleSkinPhysiologyOntology:ApocrineGland ApocrineGland SPSO_000145 MultiscaleSkinPhysiologyOntology:Apoptosis Apoptosis SPSO_000025 MultiscaleSkinPhysiologyOntology:AreolarConnectiveTissue AreolarConnectiveTissue SPSO_000167 MultiscaleSkinPhysiologyOntology:ArrectorPiliMuscle ArrectorPiliMuscle SPSO_000161 MultiscaleSkinPhysiologyOntology:ArteriovenousAnastomosis ArteriovenousAnastomosis SPSO_000163 MultiscaleSkinPhysiologyOntology:BasementMembrane BasementMembrane SPSO_000104 MultiscaleSkinPhysiologyOntology:BiologicalMacromolecule BiologicalMacromolecule SPSO_000115 MultiscaleSkinPhysiologyOntology:Birbeck_granule Birbeck granule SPSO_000084 MultiscaleSkinPhysiologyOntology:BloodPressureRegulation BloodPressureRegulation SPSO_000071 MultiscaleSkinPhysiologyOntology:Cadherin Cadherin SPSO_000098 MultiscaleSkinPhysiologyOntology:Capillary Capillary SPSO_000160 MultiscaleSkinPhysiologyOntology:CapillaryBed CapillaryBed SPSO_000184 MultiscaleSkinPhysiologyOntology:CardinalTissuePart Anatomical structure, which is a subdivision of tissue demarcated by fiat boundaries. Examples: stratum germinativum, lamina of cerebral cortex. CardinalTissuePart SPSO_000017 FMAID: 67536 MultiscaleSkinPhysiologyOntology:Catagen Catagen SPSO_000062 MultiscaleSkinPhysiologyOntology:Cell Cell SPSO_000129 MultiscaleSkinPhysiologyOntology:CellCycle CellCycle SPSO_000032 MultiscaleSkinPhysiologyOntology:CellDivision CellDivision SPSO_000042 MultiscaleSkinPhysiologyOntology:CellJunction CellJunction SPSO_000086 MultiscaleSkinPhysiologyOntology:CellToCellAdhesion CellToCellAdhesion SPSO_000003 MultiscaleSkinPhysiologyOntology:CellToMatrixAdhesion CellToMatrixAdhesion SPSO_000004 MultiscaleSkinPhysiologyOntology:Cell_adhesion Cell adhesion SPSO_000002 MultiscaleSkinPhysiologyOntology:Centriole Centriole SPSO_000085 MultiscaleSkinPhysiologyOntology:Cerumen Cerumen SPSO_000152 MultiscaleSkinPhysiologyOntology:CerumenSecretion CerumenSecretion SPSO_000045 MultiscaleSkinPhysiologyOntology:CeruminousGland CeruminousGland SPSO_000146 MultiscaleSkinPhysiologyOntology:ClathrinCoatedVesicle ClathrinCoatedVesicle SPSO_000077 MultiscaleSkinPhysiologyOntology:ClathrinCoatedVesicleFormation ClathrinCoatedVesicleFormation SPSO_000019 MultiscaleSkinPhysiologyOntology:ClubHair ClubHair SPSO_000158 MultiscaleSkinPhysiologyOntology:Collagen Collagen SPSO_000010 MultiscaleSkinPhysiologyOntology:CollagenFibre CollagenFibre SPSO_000094 MultiscaleSkinPhysiologyOntology:ConnectiveTissue ConnectiveTissue SPSO_000165 MultiscaleSkinPhysiologyOntology:Cytokinesis Cytokinesis SPSO_000036 MultiscaleSkinPhysiologyOntology:DenseIrregularConnectiveTissue DenseIrregularConnectiveTissue SPSO_000169 MultiscaleSkinPhysiologyOntology:DermalPapilla DermalPapilla SPSO_000162 MultiscaleSkinPhysiologyOntology:Dermis Dermis SPSO_000007 MultiscaleSkinPhysiologyOntology:Desmocollin Desmocollin SPSO_000004 MultiscaleSkinPhysiologyOntology:Desmoglein Desmoglein SPSO_000005 MultiscaleSkinPhysiologyOntology:Desmoplakin Desmoplakin SPSO_000003 MultiscaleSkinPhysiologyOntology:Desmosome Desmosome SPSO_000087 MultiscaleSkinPhysiologyOntology:EarlyProphase EarlyProphase SPSO_000039 MultiscaleSkinPhysiologyOntology:EccrineGland MerocrineGland EccrineGland SPSO_000144 MultiscaleSkinPhysiologyOntology:ElasticFibre ElasticFibre SPSO_000012 MultiscaleSkinPhysiologyOntology:Elastin Elastin SPSO_000011 MultiscaleSkinPhysiologyOntology:Encapsulated_nerve_ending Encapsulated nerve ending SPSO_000111 MultiscaleSkinPhysiologyOntology:Endocytosis Endocytosis SPSO_000027 MultiscaleSkinPhysiologyOntology:Endosome Endosome SPSO_000079 MultiscaleSkinPhysiologyOntology:EndothelialCell EndothelialCell SPSO_000141 MultiscaleSkinPhysiologyOntology:Endothelium Endothelium SPSO_000172 MultiscaleSkinPhysiologyOntology:Enzyme Enzyme SPSO_000126 MultiscaleSkinPhysiologyOntology:EnzymeSynthesis EnzymeSynthesis SPSO_000010 MultiscaleSkinPhysiologyOntology:Epidermis Epidermis SPSO_000171 MultiscaleSkinPhysiologyOntology:Epithelium Epithelium SPSO_000170 MultiscaleSkinPhysiologyOntology:Erythrocyte Erythrocyte SPSO_000001 MultiscaleSkinPhysiologyOntology:Eumelanin Eumelanin SPSO_000122 MultiscaleSkinPhysiologyOntology:Eumelanogenesis Eumelanogenesis SPSO_000000 MultiscaleSkinPhysiologyOntology:Exocytosis Exocytosis SPSO_000031 MultiscaleSkinPhysiologyOntology:Fibroblast Fibroblast SPSO_000134 MultiscaleSkinPhysiologyOntology:FibrousProtein FibrousProtein SPSO_000009 MultiscaleSkinPhysiologyOntology:FreeNerveEnding FreeNerveEnding SPSO_000108 MultiscaleSkinPhysiologyOntology:FusionWithEndosome FusionWithEndosome SPSO_000021 MultiscaleSkinPhysiologyOntology:Gland Gland SPSO_000142 MultiscaleSkinPhysiologyOntology:GlandOfEpidermis GlandOfEpidermis SPSO_000020 MultiscaleSkinPhysiologyOntology:Hair Hair SPSO_000155 MultiscaleSkinPhysiologyOntology:HairFollicleReceptor HairFollicleReceptor SPSO_000110 MultiscaleSkinPhysiologyOntology:HairGrowthCycle HairGrowthCycle SPSO_000059 MultiscaleSkinPhysiologyOntology:HairGrowthPhase HairGrowthPhase SPSO_000060 MultiscaleSkinPhysiologyOntology:Hemidesmosome Hemidesmosome SPSO_000088 MultiscaleSkinPhysiologyOntology:Hemoglobin Hemoglobin SPSO_000125 MultiscaleSkinPhysiologyOntology:Heparin Heparin SPSO_000118 MultiscaleSkinPhysiologyOntology:HeparinSecretion HeparinSecretion SPSO_000050 MultiscaleSkinPhysiologyOntology:Histamine Histamine SPSO_000117 MultiscaleSkinPhysiologyOntology:HistamineSecretion HistamineSecretion SPSO_000049 MultiscaleSkinPhysiologyOntology:Hypodermis Hypodermis SPSO_000183 MultiscaleSkinPhysiologyOntology:Integrin Integrin SPSO_000099 MultiscaleSkinPhysiologyOntology:IntercellularMatrixOfEndothelium IntercellularMatrixOfEndothelium SPSO_000005 MultiscaleSkinPhysiologyOntology:Intercellular_matrix_of_areolar_connective_tissue Intercellular matrix of areolar connective tissue SPSO_000006 MultiscaleSkinPhysiologyOntology:Interphase Interphase SPSO_000037 MultiscaleSkinPhysiologyOntology:InvaginationProcess InvaginationProcess SPSO_000018 MultiscaleSkinPhysiologyOntology:IrregularConnectiveTissue IrregularConnectiveTissue SPSO_000022 MultiscaleSkinPhysiologyOntology:Keratin Keratin SPSO_000095 MultiscaleSkinPhysiologyOntology:Keratinisation Keratinisation SPSO_000026 MultiscaleSkinPhysiologyOntology:Keratinocyte Keratinocyte SPSO_000131 MultiscaleSkinPhysiologyOntology:KeratinocyteMigration KeratinocyteMigration SPSO_000023 MultiscaleSkinPhysiologyOntology:KeratinocyteProliferation KeratinocyteProliferation SPSO_000024 MultiscaleSkinPhysiologyOntology:Keratohyalin Keratohyalin SPSO_000124 MultiscaleSkinPhysiologyOntology:LamellarGranule LamellarGranule SPSO_000083 MultiscaleSkinPhysiologyOntology:LamellarGranuleSecretion LamellarGranuleSecretion SPSO_000051 MultiscaleSkinPhysiologyOntology:Laminin Laminin SPSO_000100 MultiscaleSkinPhysiologyOntology:LangerhansCell LangerhansCell SPSO_000132 MultiscaleSkinPhysiologyOntology:LateProphase LateProphase SPSO_000040 MultiscaleSkinPhysiologyOntology:LayerOfEpidermis LayerOfEpidermis SPSO_000174 MultiscaleSkinPhysiologyOntology:Leukocyte Leukocyte SPSO_000137 MultiscaleSkinPhysiologyOntology:Lipid Lipid SPSO_000116 MultiscaleSkinPhysiologyOntology:Lipidsecretion Lipidsecretion SPSO_000048 MultiscaleSkinPhysiologyOntology:LooseConnectiveTissue LooseConnectiveTissue SPSO_000023 MultiscaleSkinPhysiologyOntology:Lysosome Lysosome SPSO_000078 MultiscaleSkinPhysiologyOntology:Macrophage Macrophage SPSO_000138 MultiscaleSkinPhysiologyOntology:MammaryGland MammaryGland SPSO_000147 MultiscaleSkinPhysiologyOntology:MastCell MastCell SPSO_000135 MultiscaleSkinPhysiologyOntology:Mechanoreceptor Mechanoreceptor SPSO_000005 MultiscaleSkinPhysiologyOntology:Melanin Melanin SPSO_000121 MultiscaleSkinPhysiologyOntology:MelaninTransport MelaninTransport SPSO_000011 MultiscaleSkinPhysiologyOntology:Melanocyte Melanocyte SPSO_000130 MultiscaleSkinPhysiologyOntology:Melanogenesis Melanogenesis SPSO_000022 MultiscaleSkinPhysiologyOntology:Melanosome Melanosome SPSO_000080 MultiscaleSkinPhysiologyOntology:MerkelCell MerkelCell SPSO_000133 MultiscaleSkinPhysiologyOntology:MerkelDisc MerkelDisc SPSO_000109 MultiscaleSkinPhysiologyOntology:Metaphase Metaphase SPSO_000000 MultiscaleSkinPhysiologyOntology:Milk Milk SPSO_000154 MultiscaleSkinPhysiologyOntology:MilkSecretion MilkSecretion SPSO_000047 MultiscaleSkinPhysiologyOntology:Mitosis Mitosis SPSO_000035 MultiscaleSkinPhysiologyOntology:NerveEnding NerveEnding SPSO_000107 MultiscaleSkinPhysiologyOntology:NerveFibre NerveFibre SPSO_000092 MultiscaleSkinPhysiologyOntology:Neutrophil Neutrophil SPSO_000139 MultiscaleSkinPhysiologyOntology:Noiceptor Noiceptor SPSO_000006 MultiscaleSkinPhysiologyOntology:Nucleus Nucleus SPSO_000075 MultiscaleSkinPhysiologyOntology:Organelle Organelle SPSO_000074 MultiscaleSkinPhysiologyOntology:PacinianCorpuscle PacinianCorpuscle SPSO_000112 MultiscaleSkinPhysiologyOntology:PapillaryLayerOfDermis PapillaryLayerOfDermis SPSO_000182 MultiscaleSkinPhysiologyOntology:Pericyte Pericyte SPSO_000000 MultiscaleSkinPhysiologyOntology:Phagocyte Phagocyte SPSO_000008 MultiscaleSkinPhysiologyOntology:Phagocytosis Phagocytosis SPSO_000028 MultiscaleSkinPhysiologyOntology:Phagolysosome Phagolysosome SPSO_000082 MultiscaleSkinPhysiologyOntology:PhagolysosomeFormation PhagolysosomeFormation SPSO_000016 MultiscaleSkinPhysiologyOntology:Phagosome Phagosome SPSO_000081 MultiscaleSkinPhysiologyOntology:PhagosomeFormation PhagosomeFormation SPSO_000015 MultiscaleSkinPhysiologyOntology:Pheomelanin Pheomelanin SPSO_000123 MultiscaleSkinPhysiologyOntology:Pheomelanogenesis Pheomelanogenesis SPSO_000001 MultiscaleSkinPhysiologyOntology:PhysiologicalProcess PhysiologicalProcess SPSO_000001 MultiscaleSkinPhysiologyOntology:Pinocytosis Pinocytosis SPSO_000029 MultiscaleSkinPhysiologyOntology:Plakoglobin Plakoglobin SPSO_000002 MultiscaleSkinPhysiologyOntology:Plaque Plaque SPSO_000090 MultiscaleSkinPhysiologyOntology:PlasmaMembrane PlasmaMembrane SPSO_000091 MultiscaleSkinPhysiologyOntology:PortionOfBlood PortionOfBlood SPSO_000003 MultiscaleSkinPhysiologyOntology:PortionOfBodySubstance PortionOfBodySubstance SPSO_000002 MultiscaleSkinPhysiologyOntology:PortionOfExtracellularMatrix PortionOfExtracellularMatrix SPSO_000004 MultiscaleSkinPhysiologyOntology:PortionOfPlasma PortionOfPlasma SPSO_000008 MultiscaleSkinPhysiologyOntology:PortionOfSecretedSubstance PortionOfSecretedSubstance SPSO_000007 MultiscaleSkinPhysiologyOntology:PortionOfTissue PortionOfTissue SPSO_000021 MultiscaleSkinPhysiologyOntology:Prophase Prophase SPSO_000038 MultiscaleSkinPhysiologyOntology:Protein Protein SPSO_000119 MultiscaleSkinPhysiologyOntology:ProteinFibre ProteinFibre SPSO_000093 MultiscaleSkinPhysiologyOntology:PseudopodFormation PseudopodFormation SPSO_000014 MultiscaleSkinPhysiologyOntology:ReceptorBinding ReceptorBinding SPSO_000012 MultiscaleSkinPhysiologyOntology:ReceptorMediatedEndocytosis ReceptorMediatedEndocytosis SPSO_000030 MultiscaleSkinPhysiologyOntology:ReticularFibre ReticularFibre SPSO_000101 MultiscaleSkinPhysiologyOntology:ReticularLayerOfDermis ReticularLayerOfDermis SPSO_000181 MultiscaleSkinPhysiologyOntology:RuffiniEnding RuffiniEnding SPSO_000114 MultiscaleSkinPhysiologyOntology:SebaceousGland SPSO_000148 SebaceousGland MultiscaleSkinPhysiologyOntology:Sebum SPSO_000151 Sebum MultiscaleSkinPhysiologyOntology:SebumSecretion SPSO_000044 SebumSecretion MultiscaleSkinPhysiologyOntology:SecretionProcess SPSO_000043 SecretionProcess MultiscaleSkinPhysiologyOntology:Sensation SPSO_000072 Sensation MultiscaleSkinPhysiologyOntology:SensationOfPain SPSO_000069 SensationOfPain MultiscaleSkinPhysiologyOntology:SensationOfTemperature SPSO_000070 SensationOfTemperature MultiscaleSkinPhysiologyOntology:SensationOfTouch SPSO_000068 SensationOfTouch MultiscaleSkinPhysiologyOntology:Separase SPSO_000127 Separase MultiscaleSkinPhysiologyOntology:StabilisationOfCapillaryWall SPSO_000064 StabilisationOfCapillaryWall MultiscaleSkinPhysiologyOntology:StageOfCellcycle SPSO_000034 StageOfCellcycle MultiscaleSkinPhysiologyOntology:StageOfExocytosis SPSO_000005 StageOfExocytosis MultiscaleSkinPhysiologyOntology:StageOfPhagocytosis SPSO_000013 StageOfPhagocytosis MultiscaleSkinPhysiologyOntology:StageOfReceptorMediatedEndocytosis SPSO_000017 StageOfReceptorMediatedEndocytosis MultiscaleSkinPhysiologyOntology:StemCellOfEpidermis SPSO_000140 StemCellOfEpidermis MultiscaleSkinPhysiologyOntology:StratumBasale SPSO_000175 StratumBasale MultiscaleSkinPhysiologyOntology:StratumCorneum SPSO_000179 StratumCorneum MultiscaleSkinPhysiologyOntology:StratumGranulosum SPSO_000177 StratumGranulosum MultiscaleSkinPhysiologyOntology:StratumLucidum SPSO_000178 StratumLucidum MultiscaleSkinPhysiologyOntology:StratumSpinosum SPSO_000176 StratumSpinosum MultiscaleSkinPhysiologyOntology:SubdivisionOfDermis SPSO_000018 SubdivisionOfDermis MultiscaleSkinPhysiologyOntology:Sudoriferous_gland SPSO_000143 Sudoriferous gland MultiscaleSkinPhysiologyOntology:Sweat SPSO_000153 Sweat MultiscaleSkinPhysiologyOntology:SweatSecretion SPSO_000046 SweatSecretion MultiscaleSkinPhysiologyOntology:Teleophase SPSO_000041 Teleophase MultiscaleSkinPhysiologyOntology:Telogen SPSO_000063 Telogen MultiscaleSkinPhysiologyOntology:TerminalHair SPSO_000157 TerminalHair MultiscaleSkinPhysiologyOntology:Thermoreceptor SPSO_000004 Thermoreceptor MultiscaleSkinPhysiologyOntology:Thermoregulation SPSO_000065 Thermoregulation MultiscaleSkinPhysiologyOntology:Thrombocyte SPSO_000002 Thrombocyte MultiscaleSkinPhysiologyOntology:TightJunction SPSO_000089 TightJunction MultiscaleSkinPhysiologyOntology:Tonofilament Intermediate Filament SPSO_000096 Tonofilament MultiscaleSkinPhysiologyOntology:Transcytosis SPSO_000033 Transcytosis MultiscaleSkinPhysiologyOntology:Tyrosinase SPSO_000128 Tyrosinase MultiscaleSkinPhysiologyOntology:UVProtection SPSO_000066 UVProtection MultiscaleSkinPhysiologyOntology:Uncoating SPSO_000020 Uncoating MultiscaleSkinPhysiologyOntology:UnencapsulatedNerveEndings SPSO_000003 UnencapsulatedNerveEndings MultiscaleSkinPhysiologyOntology:Vasoconstriction SPSO_000056 Vasoconstriction MultiscaleSkinPhysiologyOntology:Vasomotion SPSO_000054 Vasomotion MultiscaleSkinPhysiologyOntology:VellusHair SPSO_000156 VellusHair MultiscaleSkinPhysiologyOntology:Vesicle SPSO_000076 Vesicle MultiscaleSkinPhysiologyOntology:VesicleDocking SPSO_000009 VesicleDocking MultiscaleSkinPhysiologyOntology:VesicleFormation SPSO_000006 VesicleFormation MultiscaleSkinPhysiologyOntology:VesicleFusion SPSO_000008 VesicleFusion MultiscaleSkinPhysiologyOntology:VesicleTransport SPSO_000007 VesicleTransport MultiscaleSkinPhysiologyOntology:WaterHomeostasis SPSO_000067 WaterHomeostasis SPO_lightweight_merged:AcinarCellOfSebaceousGland AcinarCellOfSebaceousGland SPSO_000012 SPO_lightweight_merged:Actin Actin SPSO_000008 SPO_lightweight_merged:ActinMicrofilament ActinMicrofilament SPSO_000009 SPO_lightweight_merged:ActinMyofilament ActinMyofilament SPSO_000001 SPO_lightweight_merged:AmountOfMatter AmountOfMatter SPSO_000002 SPO_lightweight_merged:AnagenFunction AnagenFunction SPSO_000077 SPO_lightweight_merged:AnagenHair AnagenHair SPSO_000009 SPO_lightweight_merged:AnagenHairFollicle AnagenHairFollicle SPSO_000013 SPO_lightweight_merged:AnaphaseFunction AnaphaseFunction SPSO_000029 SPO_lightweight_merged:ApoptosisFunction ApoptosisFunction SPSO_000045 SPO_lightweight_merged:BasalLamina BasalLamina SPSO_000017 SPO_lightweight_merged:BloodPressureRegulationFunction BloodPressureRegulationFunction SPSO_000013 SPO_lightweight_merged:CardinalCellPart CardinalCellPart SPSO_000003 SPO_lightweight_merged:CardinalOrganPart CardinalOrganPart SPSO_000004 SPO_lightweight_merged:CatagenFunction CatagenFunction SPSO_000076 SPO_lightweight_merged:CatagenHair CatagenHair SPSO_000010 SPO_lightweight_merged:CatagenHairFollicle CatagenHairFollicle SPSO_000014 SPO_lightweight_merged:CellAdhesionMolecule CellAdhesionMolecule SPSO_000016 SPO_lightweight_merged:CellCycleFunction CellCycleFunction SPSO_000057 SPO_lightweight_merged:CellDeath CellDeath SPSO_000001 SPO_lightweight_merged:CellDeathFunction CellDeathFunction SPSO_000043 SPO_lightweight_merged:CellDivisionFunction CellDivisionFunction SPSO_000026 SPO_lightweight_merged:CellToCellAdhesionFunction CellToCellAdhesionFunction SPSO_000071 SPO_lightweight_merged:CellToMatrixAdhesionFunction CellToMatrixAdhesionFunction SPSO_000072 SPO_lightweight_merged:Cell_adhesionFunction Cell_adhesionFunction SPSO_000070 SPO_lightweight_merged:CellularProcess CellularProcess SPSO_000000 SPO_lightweight_merged:CellularProcessFunction CellularProcessFunction SPSO_000014 SPO_lightweight_merged:CerumenSecretionFunction CerumenSecretionFunction SPSO_000036 SPO_lightweight_merged:ClathrinCoatedVesicleFormationFunction ClathrinCoatedVesicleFormationFunction SPSO_000048 SPO_lightweight_merged:Collective Collective SPSO_000002 SPO_lightweight_merged:CollectiveOfErythrocytes Example class... CollectiveOfErythrocytes SPSO_000007 SPO_lightweight_merged:CytokinesisFunction CytokinesisFunction SPSO_000031 SPO_lightweight_merged:Cytoskeleton Cytoskeleton SPSO_000011 SPO_lightweight_merged:EarlyProphaseFunction EarlyProphaseFunction SPSO_000024 SPO_lightweight_merged:EndocytosisFunction EndocytosisFunction SPSO_000061 SPO_lightweight_merged:EnzymeSynthesisFunction EnzymeSynthesisFunction SPSO_000073 SPO_lightweight_merged:EpithelialCell EpithelialCell SPSO_000001 SPO_lightweight_merged:EumelanogenesisFunction EumelanogenesisFunction SPSO_000067 SPO_lightweight_merged:ExocytosisFunction ExocytosisFunction SPSO_000060 SPO_lightweight_merged:FusionWithEndosomeFunction FusionWithEndosomeFunction SPSO_000052 SPO_lightweight_merged:HairFollicle HairFollicle SPSO_000012 SPO_lightweight_merged:HairGrowthCycleFunction HairGrowthCycleFunction SPSO_000006 SPO_lightweight_merged:HairGrowthPhaseFunction HairGrowthPhaseFunction SPSO_000074 SPO_lightweight_merged:HeparinSecretionFunction HeparinSecretionFunction SPSO_000034 SPO_lightweight_merged:HistamineSecretionFunction HistamineSecretionFunction SPSO_000038 SPO_lightweight_merged:HolocrineGland HolocrineGland SPSO_000014 SPO_lightweight_merged:HypodermisTissue HypodermisTissue SPSO_000005 SPO_lightweight_merged:InterphaseFunction InterphaseFunction SPSO_000028 SPO_lightweight_merged:InvaginationProcessFunction InvaginationProcessFunction SPSO_000050 SPO_lightweight_merged:KeratinisationFunction KeratinisationFunction SPSO_000068 SPO_lightweight_merged:KeratinocyteMigrationFunction KeratinocyteMigrationFunction SPSO_000058 SPO_lightweight_merged:KeratinocyteProliferationFunction KeratinocyteProliferationFunction SPSO_000069 SPO_lightweight_merged:LamellarGranuleSecretionFunction LamellarGranuleSecretionFunction SPSO_000037 SPO_lightweight_merged:LaminaDensa LaminaDensa SPSO_000018 SPO_lightweight_merged:LaminaLucida LaminaLucida SPSO_000019 SPO_lightweight_merged:LateProphaseFunction LateProphaseFunction SPSO_000027 SPO_lightweight_merged:LipidsecretionFunction LipidsecretionFunction SPSO_000040 SPO_lightweight_merged:Lysis Lysis SPSO_000003 SPO_lightweight_merged:LysisFunction LysisFunction SPSO_000044 SPO_lightweight_merged:MeissnerCorpuscle MeissnerCorpuscle SPSO_000006 SPO_lightweight_merged:MelaninTransportFunction MelaninTransportFunction SPSO_000015 SPO_lightweight_merged:MelanogenesisFunction MelanogenesisFunction SPSO_000065 SPO_lightweight_merged:MerocrineGland MerocrineGland SPSO_000015 SPO_lightweight_merged:MetaphaseFunction MetaphaseFunction SPSO_000030 SPO_lightweight_merged:Microtubule Microtubule SPSO_000021 SPO_lightweight_merged:MilkSecretionFunction MilkSecretionFunction SPSO_000039 SPO_lightweight_merged:MitosisFunction MitosisFunction SPSO_000025 SPO_lightweight_merged:MuscleCell MuscleCell SPSO_000018 SPO_lightweight_merged:Myofibril Myofibril SPSO_000000 SPO_lightweight_merged:Myosin Myosin SPSO_000003 SPO_lightweight_merged:MyosinMyofilament MyosinMyofilament SPSO_000002 SPO_lightweight_merged:Nail Nail SPSO_000008 SPO_lightweight_merged:PhagocytosisFunction PhagocytosisFunction SPSO_000062 SPO_lightweight_merged:PhagolysosomeFormationFunction PhagolysosomeFormationFunction SPSO_000056 SPO_lightweight_merged:PhagosomeFormationFunction PhagosomeFormationFunction SPSO_000055 SPO_lightweight_merged:PheomelanogenesisFunction PheomelanogenesisFunction SPSO_000066 SPO_lightweight_merged:Phospholipid Phospholipid SPSO_000004 SPO_lightweight_merged:PhysicalObject PhysicalObject SPSO_000001 SPO_lightweight_merged:PhysiologicalFunction PhysiologicalFunction SPSO_000000 SPO_lightweight_merged:PilosebaceousUnit PilosebaceousUnit SPSO_000005 SPO_lightweight_merged:PinocytosisFunction PinocytosisFunction SPSO_000063 SPO_lightweight_merged:PortionOfGroundSubstance PortionOfGroundSubstance SPSO_000019 SPO_lightweight_merged:PortionOfGroundSubstanceOfAreolarConnectiveTissue PortionOfGroundSubstanceOfAreolarConnectiveTissue SPSO_000020 SPO_lightweight_merged:ProphaseFunction ProphaseFunction SPSO_000023 SPO_lightweight_merged:PseudopodFormationFunction PseudopodFormationFunction SPSO_000054 SPO_lightweight_merged:ReceptorBindingFunction ReceptorBindingFunction SPSO_000049 SPO_lightweight_merged:ReceptorMediatedEndocytosisFunction ReceptorMediatedEndocytosisFunction SPSO_000064 SPO_lightweight_merged:ReticularLamina ReticularLamina SPSO_000020 SPO_lightweight_merged:SebumSecretionFunction SPSO_000042 SebumSecretionFunction SPO_lightweight_merged:SecretionByExocytosis SPSO_000004 SecretionByExocytosis SPO_lightweight_merged:SecretionByExocytosisFunction SPSO_000033 SecretionByExocytosisFunction SPO_lightweight_merged:SecretionByLysis Holocrine Secretion SPSO_000005 SecretionByLysis SPO_lightweight_merged:SecretionByLysisFunction SPSO_000041 SecretionByLysisFunction SPO_lightweight_merged:SecretionProcessFunction SPSO_000032 SecretionProcessFunction SPO_lightweight_merged:SensationFunction SPSO_000009 SensationFunction SPO_lightweight_merged:SensationOfPainFunction SPSO_000010 SensationOfPainFunction SPO_lightweight_merged:SensationOfTemperatureFunction SPSO_000011 SensationOfTemperatureFunction SPO_lightweight_merged:SensationOfTouchFunction SPSO_000012 SensationOfTouchFunction SPO_lightweight_merged:SensoryReceptor SPSO_000016 SensoryReceptor SPO_lightweight_merged:SkinAppendage SPSO_000007 SkinAppendage SPO_lightweight_merged:SmoothMuscleTissue SPSO_000017 SmoothMuscleTissue SPO_lightweight_merged:StabilisationOfCapillaryWallFunction SPSO_000008 StabilisationOfCapillaryWallFunction SPO_lightweight_merged:StageOfCellcycleFunction SPSO_000021 StageOfCellcycleFunction SPO_lightweight_merged:StageOfEndocytosis SPSO_000000 StageOfEndocytosis SPO_lightweight_merged:StageOfEndocytosisFunction SPSO_000046 StageOfEndocytosisFunction SPO_lightweight_merged:StageOfExocytosisFunction SPSO_000016 StageOfExocytosisFunction SPO_lightweight_merged:StageOfPhagocytosisFunction SPSO_000053 StageOfPhagocytosisFunction SPO_lightweight_merged:StageOfReceptorMediatedEndocytosisFunction SPSO_000047 StageOfReceptorMediatedEndocytosisFunction SPO_lightweight_merged:SubdivisionOfEpidermis SPSO_000006 SubdivisionOfEpidermis SPO_lightweight_merged:SweatSecretionFunction SPSO_000035 SweatSecretionFunction SPO_lightweight_merged:TeleophaseFunction SPSO_000022 TeleophaseFunction SPO_lightweight_merged:TelogenFunction SPSO_000075 TelogenFunction SPO_lightweight_merged:TelogenHair SPSO_000011 TelogenHair SPO_lightweight_merged:TelogenHairFollicle SPSO_000015 TelogenHairFollicle SPO_lightweight_merged:ThermoregulationFunction SPSO_000007 ThermoregulationFunction SPO_lightweight_merged:TranscytosisFunction SPSO_000059 TranscytosisFunction SPO_lightweight_merged:Type_III_Collagen SPSO_000010 Type III Collagen SPO_lightweight_merged:Type_IV_Collagen SPSO_000022 Type IV Collagen SPO_lightweight_merged:Type_I_Collagen SPSO_000013 Type I Collagen SPO_lightweight_merged:Type_VI_Collagen SPSO_000024 Type VI Collagen SPO_lightweight_merged:Type_V_Collagen SPSO_000025 Type V Collagen SPO_lightweight_merged:UVProtectionFunction SPSO_000001 UVProtectionFunction SPO_lightweight_merged:UncoatingFunction SPSO_000051 UncoatingFunction SPO_lightweight_merged:VasoconstrictionFunction SPSO_000005 VasoconstrictionFunction SPO_lightweight_merged:VasodilatationFunction SPSO_000004 VasodilatationFunction SPO_lightweight_merged:Vasodilation SPSO_000078 Vasodilation SPO_lightweight_merged:VasomotionFunction SPSO_000003 VasomotionFunction SPO_lightweight_merged:VesicleDockingFunction SPSO_000020 VesicleDockingFunction SPO_lightweight_merged:VesicleFormationFunction SPSO_000019 VesicleFormationFunction SPO_lightweight_merged:VesicleFusionFunction SPSO_000017 VesicleFusionFunction SPO_lightweight_merged:VesicleTransportFunction SPSO_000018 VesicleTransportFunction SPO_lightweight_merged:WaterHomeostasisFunction SPSO_000002 WaterHomeostasisFunction http://purl.org/obo/owl/ro#genid15 PMID:15892874 http://purl.org/obo/owl/ro#genid13 PMID:15892874 PMID:15892874 http://purl.org/obo/owl/ro#genid11 http://purl.org/obo/owl/ro#genid2 http://purl.org/obo/owl/ro#genid9 PMID:15892874 PMID:15892874 A relationship between two classes (terms). Relationships between classes are expressed in terms of relations on underlying instances. http://purl.org/obo/owl/ro#genid7 PMID:15892874 http://purl.org/obo/owl/ro#genid26 PMID:15892874 http://purl.org/obo/owl/ro#genid4 PMID:15892874 http://purl.org/obo/owl/ro#genid23 PMID:15892874 derived_from http://purl.org/obo/owl/ro#genid19 PMID:15892874 PMID:15892874 http://purl.org/obo/owl/ro#genid21 http://purl.org/obo/owl/ro#genid17 PMID:15892874 SPSO_000026 has_function The relation between a grain and a collective. The boundary property that indicates a shift in level of collectivity ("granularity"). The loss of ndividual grains does not diminish the whole. Collectives have emergent properties not directly predictable from the grains. http://purl.org/obo/owl/ro#genid3 relationship Note that adjacent_to as thus defined is not a symmetric relation, in contrast to its instance-level counterpart. For it can be the case that Cs are in general such as to be adjacent to instances of C1 while no analogous statement holds for C1s in general in relation to instances of C. Examples are: nuclear membrane adjacent_to cytoplasm; seminal vesicle adjacent_to urinary bladder; ovary adjacent_to parietal pelvic peritoneum adjacent_to relationship ro_bfo_bridge agent_in relationship ro_bfo_bridge derived_into http://purl.org/obo/owl/ro#genid25 http://purl.org/obo/owl/ro#genid24 relationship ro_bfo_bridge Derivation as a relation between instances. The temporal relation of derivation is more complex. Transformation, on the instance level, is just the relation of identity: each adult is identical to some child existing at some earlier time. Derivation on the instance-level is a relation holding between non-identicals. More precisely, it holds between distinct material continuants when one succeeds the other across a temporal divide in such a way that at least a biologically significant portion of the matter of the earlier continuant is inherited by the later. Thus we will have axioms to the effect that from c derives_from c1 we can infer that c and c1 are not identical and that there is some instant of time t such that c1 exists only prior to and c only subsequent to t. We will also be able to infer that the spatial region occupied by c as it begins to exist at t overlaps with the spatial region occupied by c1 as it ceases to exist in the same instant. derives_from http://purl.org/obo/owl/ro#genid6 relationship ro_bfo_bridge has_agent relationship has_part http://purl.org/obo/owl/ro#genid20 relationship ro_bfo_bridge Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus located_in relationship ro_bfo_bridge location_of relationship ro_bfo_bridge participates_in relationship ro_bfo_bridge precedes http://purl.org/obo/owl/ro#genid10 relationship ro_bfo_bridge When an embryonic oenocyte (a type of insect cell) is transformed into a larval oenocyte, one and the same continuant entity preserves its identity while instantiating distinct classes at distinct times. The class-level relation transformation_of obtains between continuant classes C and C1 wherever each instance of the class C is such as to have existed at some earlier time as an instance of the distinct class C1 (see Figure 2 in paper). This relation is illustrated first of all at the molecular level of granularity by the relation between mature RNA and the pre-RNA from which it is processed, or between (UV-induced) thymine-dimer and thymine dinucleotide. At coarser levels of granularity it is illustrated by the transformations involved in the creation of red blood cells, for example, from reticulocyte to erythrocyte, and by processes of development, for example, from larva to pupa, or from (post-gastrular) embryo to fetus or from child to adult. It is also manifest in pathological transformations, for example, of normal colon into carcinomatous colon. In each such case, one and the same continuant entity instantiates distinct classes at different times in virtue of phenotypic changes. transformation_of Tariq Abdulla An ontology that describes physiological processes and functions in the skin, across a wide range of spatial scale. Skin Physiology Ontology